                         SEQUENCE LISTING

<110>  Evonik Degussa GmbH
 
<120>  Allele des rel-Gens aus coryneformen Bakterien

<130>  200600725


<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  2283
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(2280)
<223>  rel-Wildtyp-Gen

<220>
<221>  misc_feature
<222>  (785)..(785)
<223>  Guanin

<400>  1
atg agt ctg gag cgc aac aca caa aaa tct tcc atg ggt gtg cga agc       48
Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser         
1               5                   10                  15              

atg tca gcc agg ctt gcc cgc agc ctc aca gga aac cgc gtt cgc acc       96
Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr         
            20                  25                  30                  

aac cct gtg ctg gat ccg ctg ctg agc atc cac cgg caa ttt cac cca      144
Asn Pro Val Leu Asp Pro Leu Leu Ser Ile His Arg Gln Phe His Pro         
        35                  40                  45                      

cgc gcc gac gta caa gtg ttg gaa cgt gca tat gac acc gcg gaa cgt      192
Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg         
    50                  55                  60                          

ctt cat gat ggt gtg att cga aaa tcg ggc gat ccg tat att acc cac      240
Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His         
65                  70                  75                  80          

ccg ttg gct gtc gcc acc atc gcc gcg gaa atc ggc atg gac acc acc      288
Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr         
                85                  90                  95              

acg ctc gtc gca gcc ttg ttg cat gac acg gtg gaa gac acc gac tac      336
Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr         
            100                 105                 110                 

tct ttg gac gat ctc acc cga gat ttc gga gaa gaa gtt gcc agg ctt      384
Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu         
        115                 120                 125                     

gtc gac ggt gtc acc aag ctc gac aaa gtc gca cta ggt gct gcc gcg      432
Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala         
    130                 135                 140                         

gag gcc gaa acg att cgc aaa atg atc gtc gcc atg agc cag gac ccc      480
Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro         
145                 150                 155                 160         

cgc gtg ctg gtg att aaa gtg gcc gac cgt ttg cac aat atg cgc acc      528
Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr         
                165                 170                 175             

atg cgg ttc ctg ccg ccg gaa aag caa gct aaa aaa gca cgc caa acc      576
Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr         
            180                 185                 190                 

ctt gaa gtg att gct cct ttg gca cac cgc ctg ggc atg gcc agc gtg      624
Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val         
        195                 200                 205                     

aaa tgg gaa ttg gaa gat cta tcc ttt gcc att ttg tac ccc aag aag      672
Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys         
    210                 215                 220                         

tac gaa gag atc gtg cgt ctt gtt gcc gac cgc gcg ccc tct aga gac      720
Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp         
225                 230                 235                 240         

cgg tac ctc aaa gaa att att gat caa gtc acc ggt ggc ttg cgc gaa      768
Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu         
                245                 250                 255             

aac aac atc gcg gca gga gtg ctt ggt cga cca aag cac tac tgg tct      816
Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser         
            260                 265                 270                 

atc tat caa aag atg atc gtt cgc ggt cgt gat ttt gac gat att ttt      864
Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe         
        275                 280                 285                     

gat ctt gtt ggc atc cgc atc ctg gta gac aac gtg aac aac tgt tac      912
Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr         
    290                 295                 300                         

gcc gcc atc ggt gtc gtg cac tcc ctg ttc aat gct ctg cct ggc cga      960
Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg         
305                 310                 315                 320         

ttc aaa gac tat att tca gcc ccg cgc ttc ggt gtc tac caa tcc ctg     1008
Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu         
                325                 330                 335             

cac acc acc gtg atg gga cct ggc ggt aag cct ctg gaa gtt cag gca     1056
His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala         
            340                 345                 350                 

cgt acc cac gac atg cac tac aac gcc gaa ttc ggc att gca gcg cac     1104
Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His         
        355                 360                 365                     

tgg cga tac aaa gaa acc aaa ggc agc cac agt ggc gag caa gcc gaa     1152
Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu         
    370                 375                 380                         

gtg gat caa atg gcg tgg atg cgc caa ctt ctg gac tgg caa aaa gaa     1200
Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu         
385                 390                 395                 400         

gca gcc gac ccc aac gag ttc ctg gac agc ctg cgc tac gat ctg act     1248
Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr         
                405                 410                 415             

tcc aag cag atc ttc gtg ttc aca ccc aaa ggt gat gtg gtc aac ctg     1296
Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu         
            420                 425                 430                 

ccg gtg aac tcc acc ccg gtg gac ttc gcc tac gcg gtg cac acc gaa     1344
Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu         
        435                 440                 445                     

gtg ggg cac cgc tgc atc ggc gcc aaa atc aac ggc aaa ctg gtc gct     1392
Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala         
    450                 455                 460                         

ttg gaa acg aaa ctc aaa tcc ggc gat cgt gtt gaa gtc ttt acc tcc     1440
Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser         
465                 470                 475                 480         

aag gac caa aac gct ggc cca agt agg gga tgg caa gaa ttt gtt gtc     1488
Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val         
                485                 490                 495             

tca cct cgt gca aag gcc aag att cgc cag tgg ttt gcc aag gaa cga     1536
Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg         
            500                 505                 510                 

cgc gaa gaa tac cta gaa gcc gga cgc gat gcg ctg gca gca gtt att     1584
Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile         
        515                 520                 525                     

cag cgt ggc ggc ctg cca atg cac cgc ttg ttc acc gcg tcc tcc atg     1632
Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met         
    530                 535                 540                         

aag acg gtg gca aca gag ctg cac tac cca gat gta gat gcg ctc tac     1680
Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr         
545                 550                 555                 560         

aca gcc atc ggc tcc ggt tct gta tct gcg caa cac gta gtc aac cgt     1728
Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg         
                565                 570                 575             

ctc atg gct atc ttt ggt gac gaa gaa gat gcc gaa gac gca ttg gtt     1776
Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val         
            580                 585                 590                 

gca cgc acc cca ttc agc gag ctg gtc aac tcc cgt gcc acc acg gaa     1824
Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu         
        595                 600                 605                     

agc agc acc ggc atc ctg gtc gaa ggc agc cca gat gtc atg gct aag     1872
Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys         
    610                 615                 620                         

ctc gct aaa tgc tgt atg cca gtg cca gga gat gaa atc ttt gga ttc     1920
Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe         
625                 630                 635                 640         

gtc acc cgt ggt ggc ggt gtc tcc gta cac cga aca gac tgc acg aat     1968
Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn         
                645                 650                 655             

gtg gaa aag ctc aaa gaa gag cca gaa cgc att gtc tcc gtc tcc tgg     2016
Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp         
            660                 665                 670                 

gct tcg gaa ggt caa ggt tca gta ttc tct gcc aca ctg cag ctt gaa     2064
Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu         
        675                 680                 685                     

gca ctt gat cgc gca ggc ctg ctc ttt gag ctc acc cgc gta atc aac     2112
Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn         
    690                 695                 700                         

gaa caa aag gtc tcc gtt acc gca atg aac tcc cat tgc tca gaa gac     2160
Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp         
705                 710                 715                 720         

cgc gta gcc acc gtg cgc ttc acc ttt gcg gtc tct gac acc aag cag     2208
Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln         
                725                 730                 735             

ttg gga tcc ctg atg aca cag ctg cgc aat gcc gaa gga gtg ttt gat     2256
Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp         
            740                 745                 750                 

gtc tac cga gtg acc tcg ggt ggc tag                                 2283
Val Tyr Arg Val Thr Ser Gly Gly                                         
        755                 760                                         


<210>  2
<211>  760
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  2

Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 
1               5                   10                  15      


Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 
            20                  25                  30          


Asn Pro Val Leu Asp Pro Leu Leu Ser Ile His Arg Gln Phe His Pro 
        35                  40                  45              


Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg 
    50                  55                  60                  


Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 
65                  70                  75                  80  


Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 
                85                  90                  95      


Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr 
            100                 105                 110         


Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu 
        115                 120                 125             


Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala 
    130                 135                 140                 


Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro 
145                 150                 155                 160 


Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr 
                165                 170                 175     


Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr 
            180                 185                 190         


Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val 
        195                 200                 205             


Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys 
    210                 215                 220                 


Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp 
225                 230                 235                 240 


Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu 
                245                 250                 255     


Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser 
            260                 265                 270         


Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe 
        275                 280                 285             


Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr 
    290                 295                 300                 


Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg 
305                 310                 315                 320 


Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu 
                325                 330                 335     


His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala 
            340                 345                 350         


Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His 
        355                 360                 365             


Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu 
    370                 375                 380                 


Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu 
385                 390                 395                 400 


Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr 
                405                 410                 415     


Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu 
            420                 425                 430         


Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu 
        435                 440                 445             


Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala 
    450                 455                 460                 


Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser 
465                 470                 475                 480 


Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val 
                485                 490                 495     


Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg 
            500                 505                 510         


Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile 
        515                 520                 525             


Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met 
    530                 535                 540                 


Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr 
545                 550                 555                 560 


Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg 
                565                 570                 575     


Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val 
            580                 585                 590         


Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu 
        595                 600                 605             


Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys 
    610                 615                 620                 


Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe 
625                 630                 635                 640 


Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn 
                645                 650                 655     


Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp 
            660                 665                 670         


Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu 
        675                 680                 685             


Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn 
    690                 695                 700                 


Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp 
705                 710                 715                 720 


Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln 
                725                 730                 735     


Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp 
            740                 745                 750         


Val Tyr Arg Val Thr Ser Gly Gly 
        755                 760 


<210>  3
<211>  3800
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (751)..(3033)
<223>  rel-Wildtyp-Gen

<220>
<221>  misc_feature
<222>  (1535)..(1535)
<223>  Guanin

<400>  3
aggcgcaact gaagaacaat tgtgggctga agtcccatca attccactag cagcgcaacc     60

ccgagtgttt gtgatagatc gcacagtcgg taacgttgtt gttaatacag acctagccgg    120

tatcggatgg aacatgaccg ttggtccaga agtgaggaat aagtagtgag cgaacaagct    180

ctaagcacct tcgacagggc acgtgaggcc ctggacaaga aaacccgata tgtgcaggat    240

ttcccagaaa agggtgtgct ttttgaagac ctcaccccgg tgttgggcga tgcagaatca    300

tttgtggccg tggtggacgc catggctgaa gctgcagaaa aactgaatgc agaaatcatc    360

ggtggcttgg atgcgcgagg attcctcctc ggatctgctg tcgcttacaa actcggccta    420

ggtgtgctgg ctatccgcaa gaagggaaag ctccccccac ctgtggtgac ccaggagtat    480

gaacttgaat acggcactgc agcactcgag ctgcccagtg aaggaatcga cattgctggt    540

aaaaacatcg ttttgatcga cgatgtgctg gcaaccggcg gcaccttggg cgctgcacgt    600

aaactaattg aatcgtgtga cggacatgtt tccggatatg ttcttgccat tgaggtccca    660

ggcctcggcg gtagggataa tcttggtgat aggcccgtca ttgtggtcag agatcctcag    720

tagaaggatc gaaagaaagg cggcaggaaa atg agt ctg gag cgc aac aca caa     774
                                 Met Ser Leu Glu Arg Asn Thr Gln        
                                 1               5                      

aaa tct tcc atg ggt gtg cga agc atg tca gcc agg ctt gcc cgc agc      822
Lys Ser Ser Met Gly Val Arg Ser Met Ser Ala Arg Leu Ala Arg Ser         
    10                  15                  20                          

ctc aca gga aac cgc gtt cgc acc aac cct gtg ctg gat ccg ctg ctg      870
Leu Thr Gly Asn Arg Val Arg Thr Asn Pro Val Leu Asp Pro Leu Leu         
25                  30                  35                  40          

agc atc cac cgg caa ttt cac cca cgc gcc gac gta caa gtg ttg gaa      918
Ser Ile His Arg Gln Phe His Pro Arg Ala Asp Val Gln Val Leu Glu         
                45                  50                  55              

cgt gca tat gac acc gcg gaa cgt ctt cat gat ggt gtg att cga aaa      966
Arg Ala Tyr Asp Thr Ala Glu Arg Leu His Asp Gly Val Ile Arg Lys         
            60                  65                  70                  

tcg ggc gat ccg tat att acc cac ccg ttg gct gtc gcc acc atc gcc     1014
Ser Gly Asp Pro Tyr Ile Thr His Pro Leu Ala Val Ala Thr Ile Ala         
        75                  80                  85                      

gcg gaa atc ggc atg gac acc acc acg ctc gtc gca gcc ttg ttg cat     1062
Ala Glu Ile Gly Met Asp Thr Thr Thr Leu Val Ala Ala Leu Leu His         
    90                  95                  100                         

gac acg gtg gaa gac acc gac tac tct ttg gac gat ctc acc cga gat     1110
Asp Thr Val Glu Asp Thr Asp Tyr Ser Leu Asp Asp Leu Thr Arg Asp         
105                 110                 115                 120         

ttc gga gaa gaa gtt gcc agg ctt gtc gac ggt gtc acc aag ctc gac     1158
Phe Gly Glu Glu Val Ala Arg Leu Val Asp Gly Val Thr Lys Leu Asp         
                125                 130                 135             

aaa gtc gca cta ggt gct gcc gcg gag gcc gaa acg att cgc aaa atg     1206
Lys Val Ala Leu Gly Ala Ala Ala Glu Ala Glu Thr Ile Arg Lys Met         
            140                 145                 150                 

atc gtc gcc atg agc cag gac ccc cgc gtg ctg gtg att aaa gtg gcc     1254
Ile Val Ala Met Ser Gln Asp Pro Arg Val Leu Val Ile Lys Val Ala         
        155                 160                 165                     

gac cgt ttg cac aat atg cgc acc atg cgg ttc ctg ccg ccg gaa aag     1302
Asp Arg Leu His Asn Met Arg Thr Met Arg Phe Leu Pro Pro Glu Lys         
    170                 175                 180                         

caa gct aaa aaa gca cgc caa acc ctt gaa gtg att gct cct ttg gca     1350
Gln Ala Lys Lys Ala Arg Gln Thr Leu Glu Val Ile Ala Pro Leu Ala         
185                 190                 195                 200         

cac cgc ctg ggc atg gcc agc gtg aaa tgg gaa ttg gaa gat cta tcc     1398
His Arg Leu Gly Met Ala Ser Val Lys Trp Glu Leu Glu Asp Leu Ser         
                205                 210                 215             

ttt gcc att ttg tac ccc aag aag tac gaa gag atc gtg cgt ctt gtt     1446
Phe Ala Ile Leu Tyr Pro Lys Lys Tyr Glu Glu Ile Val Arg Leu Val         
            220                 225                 230                 

gcc gac cgc gcg ccc tct aga gac cgg tac ctc aaa gaa att att gat     1494
Ala Asp Arg Ala Pro Ser Arg Asp Arg Tyr Leu Lys Glu Ile Ile Asp         
        235                 240                 245                     

caa gtc acc ggt ggc ttg cgc gaa aac aac atc gcg gca gga gtg ctt     1542
Gln Val Thr Gly Gly Leu Arg Glu Asn Asn Ile Ala Ala Gly Val Leu         
    250                 255                 260                         

ggt cga cca aag cac tac tgg tct atc tat caa aag atg atc gtt cgc     1590
Gly Arg Pro Lys His Tyr Trp Ser Ile Tyr Gln Lys Met Ile Val Arg         
265                 270                 275                 280         

ggt cgt gat ttt gac gat att ttt gat ctt gtt ggc atc cgc atc ctg     1638
Gly Arg Asp Phe Asp Asp Ile Phe Asp Leu Val Gly Ile Arg Ile Leu         
                285                 290                 295             

gta gac aac gtg aac aac tgt tac gcc gcc atc ggt gtc gtg cac tcc     1686
Val Asp Asn Val Asn Asn Cys Tyr Ala Ala Ile Gly Val Val His Ser         
            300                 305                 310                 

ctg ttc aat gct ctg cct ggc cga ttc aaa gac tat att tca gcc ccg     1734
Leu Phe Asn Ala Leu Pro Gly Arg Phe Lys Asp Tyr Ile Ser Ala Pro         
        315                 320                 325                     

cgc ttc ggt gtc tac caa tcc ctg cac acc acc gtg atg gga cct ggc     1782
Arg Phe Gly Val Tyr Gln Ser Leu His Thr Thr Val Met Gly Pro Gly         
    330                 335                 340                         

ggt aag cct ctg gaa gtt cag gca cgt acc cac gac atg cac tac aac     1830
Gly Lys Pro Leu Glu Val Gln Ala Arg Thr His Asp Met His Tyr Asn         
345                 350                 355                 360         

gcc gaa ttc ggc att gca gcg cac tgg cga tac aaa gaa acc aaa ggc     1878
Ala Glu Phe Gly Ile Ala Ala His Trp Arg Tyr Lys Glu Thr Lys Gly         
                365                 370                 375             

agc cac agt ggc gag caa gcc gaa gtg gat caa atg gcg tgg atg cgc     1926
Ser His Ser Gly Glu Gln Ala Glu Val Asp Gln Met Ala Trp Met Arg         
            380                 385                 390                 

caa ctt ctg gac tgg caa aaa gaa gca gcc gac ccc aac gag ttc ctg     1974
Gln Leu Leu Asp Trp Gln Lys Glu Ala Ala Asp Pro Asn Glu Phe Leu         
        395                 400                 405                     

gac agc ctg cgc tac gat ctg act tcc aag cag atc ttc gtg ttc aca     2022
Asp Ser Leu Arg Tyr Asp Leu Thr Ser Lys Gln Ile Phe Val Phe Thr         
    410                 415                 420                         

ccc aaa ggt gat gtg gtc aac ctg ccg gtg aac tcc acc ccg gtg gac     2070
Pro Lys Gly Asp Val Val Asn Leu Pro Val Asn Ser Thr Pro Val Asp         
425                 430                 435                 440         

ttc gcc tac gcg gtg cac acc gaa gtg ggg cac cgc tgc atc ggc gcc     2118
Phe Ala Tyr Ala Val His Thr Glu Val Gly His Arg Cys Ile Gly Ala         
                445                 450                 455             

aaa atc aac ggc aaa ctg gtc gct ttg gaa acg aaa ctc aaa tcc ggc     2166
Lys Ile Asn Gly Lys Leu Val Ala Leu Glu Thr Lys Leu Lys Ser Gly         
            460                 465                 470                 

gat cgt gtt gaa gtc ttt acc tcc aag gac caa aac gct ggc cca agt     2214
Asp Arg Val Glu Val Phe Thr Ser Lys Asp Gln Asn Ala Gly Pro Ser         
        475                 480                 485                     

agg gga tgg caa gaa ttt gtt gtc tca cct cgt gca aag gcc aag att     2262
Arg Gly Trp Gln Glu Phe Val Val Ser Pro Arg Ala Lys Ala Lys Ile         
    490                 495                 500                         

cgc cag tgg ttt gcc aag gaa cga cgc gaa gaa tac cta gaa gcc gga     2310
Arg Gln Trp Phe Ala Lys Glu Arg Arg Glu Glu Tyr Leu Glu Ala Gly         
505                 510                 515                 520         

cgc gat gcg ctg gca gca gtt att cag cgt ggc ggc ctg cca atg cac     2358
Arg Asp Ala Leu Ala Ala Val Ile Gln Arg Gly Gly Leu Pro Met His         
                525                 530                 535             

cgc ttg ttc acc gcg tcc tcc atg aag acg gtg gca aca gag ctg cac     2406
Arg Leu Phe Thr Ala Ser Ser Met Lys Thr Val Ala Thr Glu Leu His         
            540                 545                 550                 

tac cca gat gta gat gcg ctc tac aca gcc atc ggc tcc ggt tct gta     2454
Tyr Pro Asp Val Asp Ala Leu Tyr Thr Ala Ile Gly Ser Gly Ser Val         
        555                 560                 565                     

tct gcg caa cac gta gtc aac cgt ctc atg gct atc ttt ggt gac gaa     2502
Ser Ala Gln His Val Val Asn Arg Leu Met Ala Ile Phe Gly Asp Glu         
    570                 575                 580                         

gaa gat gcc gaa gac gca ttg gtt gca cgc acc cca ttc agc gag ctg     2550
Glu Asp Ala Glu Asp Ala Leu Val Ala Arg Thr Pro Phe Ser Glu Leu         
585                 590                 595                 600         

gtc aac tcc cgt gcc acc acg gaa agc agc acc ggc atc ctg gtc gaa     2598
Val Asn Ser Arg Ala Thr Thr Glu Ser Ser Thr Gly Ile Leu Val Glu         
                605                 610                 615             

ggc agc cca gat gtc atg gct aag ctc gct aaa tgc tgt atg cca gtg     2646
Gly Ser Pro Asp Val Met Ala Lys Leu Ala Lys Cys Cys Met Pro Val         
            620                 625                 630                 

cca gga gat gaa atc ttt gga ttc gtc acc cgt ggt ggc ggt gtc tcc     2694
Pro Gly Asp Glu Ile Phe Gly Phe Val Thr Arg Gly Gly Gly Val Ser         
        635                 640                 645                     

gta cac cga aca gac tgc acg aat gtg gaa aag ctc aaa gaa gag cca     2742
Val His Arg Thr Asp Cys Thr Asn Val Glu Lys Leu Lys Glu Glu Pro         
    650                 655                 660                         

gaa cgc att gtc tcc gtc tcc tgg gct tcg gaa ggt caa ggt tca gta     2790
Glu Arg Ile Val Ser Val Ser Trp Ala Ser Glu Gly Gln Gly Ser Val         
665                 670                 675                 680         

ttc tct gcc aca ctg cag ctt gaa gca ctt gat cgc gca ggc ctg ctc     2838
Phe Ser Ala Thr Leu Gln Leu Glu Ala Leu Asp Arg Ala Gly Leu Leu         
                685                 690                 695             

ttt gag ctc acc cgc gta atc aac gaa caa aag gtc tcc gtt acc gca     2886
Phe Glu Leu Thr Arg Val Ile Asn Glu Gln Lys Val Ser Val Thr Ala         
            700                 705                 710                 

atg aac tcc cat tgc tca gaa gac cgc gta gcc acc gtg cgc ttc acc     2934
Met Asn Ser His Cys Ser Glu Asp Arg Val Ala Thr Val Arg Phe Thr         
        715                 720                 725                     

ttt gcg gtc tct gac acc aag cag ttg gga tcc ctg atg aca cag ctg     2982
Phe Ala Val Ser Asp Thr Lys Gln Leu Gly Ser Leu Met Thr Gln Leu         
    730                 735                 740                         

cgc aat gcc gaa gga gtg ttt gat gtc tac cga gtg acc tcg ggt ggc     3030
Arg Asn Ala Glu Gly Val Phe Asp Val Tyr Arg Val Thr Ser Gly Gly         
745                 750                 755                 760         

tag aggcctttag attgtgaaaa agccttgggc ttcaaccacc gtgtgttgac          3083

acggttttgg ggttggattt aacgctggaa attttactgc aatgaacgct ggaaagcagt   3143

agcgaaggtc aaaccagcgc tgaggacgcc aacgatgcca gtaataacga cgacgtaatc   3203

caaaatggtg tcagagtcaa tgtcagaaga tccgttggtg ctaccgtttc ttcttctacg   3263

gtgtcagcca cgtacacaac ctgtgctggt gcgacttctt cagcctgtgc aggaacggag   3323

atggaggttg ctgccattgc agcagctgtg ccgagtgcga cgaggggagt acgagaaaat   3383

agcttcattg ctaaacccct taggtttaaa tattcgaata cgaaagttac tttatgtgca   3443

ctttcaccat tgtgcaacta tatgtgcagg tcaaagctga tattttgcta agaaaagtgc   3503

aaagcgattc gagctgacgc gcagcccata tcgtcaaaaa atcctttgtg aatggtgatt   3563

cacaaaggat tagtcgcgta aggcggaaat tacttcagga aggaatccag cttggtactg   3623

aaggttaaaa tggtggttag tgcaccgatg actgctgtga tgatcttgat ccagttttcg   3683

atgttgtcag tgtcggaaga accgctggaa ggctcttcgc tggacgggtc ttcgttgaaa   3743

tcaaagttaa cgtaaacttc tgcttcaacg cctgcttcgt tcttggcaat gatcttt      3800


<210>  4
<211>  760
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  4

Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 
1               5                   10                  15      


Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 
            20                  25                  30          


Asn Pro Val Leu Asp Pro Leu Leu Ser Ile His Arg Gln Phe His Pro 
        35                  40                  45              


Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg 
    50                  55                  60                  


Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 
65                  70                  75                  80  


Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 
                85                  90                  95      


Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr 
            100                 105                 110         


Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu 
        115                 120                 125             


Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala 
    130                 135                 140                 


Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro 
145                 150                 155                 160 


Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr 
                165                 170                 175     


Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr 
            180                 185                 190         


Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val 
        195                 200                 205             


Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys 
    210                 215                 220                 


Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp 
225                 230                 235                 240 


Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu 
                245                 250                 255     


Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser 
            260                 265                 270         


Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe 
        275                 280                 285             


Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr 
    290                 295                 300                 


Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg 
305                 310                 315                 320 


Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu 
                325                 330                 335     


His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala 
            340                 345                 350         


Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His 
        355                 360                 365             


Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu 
    370                 375                 380                 


Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu 
385                 390                 395                 400 


Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr 
                405                 410                 415     


Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu 
            420                 425                 430         


Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu 
        435                 440                 445             


Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala 
    450                 455                 460                 


Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser 
465                 470                 475                 480 


Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val 
                485                 490                 495     


Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg 
            500                 505                 510         


Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile 
        515                 520                 525             


Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met 
    530                 535                 540                 


Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr 
545                 550                 555                 560 


Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg 
                565                 570                 575     


Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val 
            580                 585                 590         


Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu 
        595                 600                 605             


Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys 
    610                 615                 620                 


Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe 
625                 630                 635                 640 


Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn 
                645                 650                 655     


Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp 
            660                 665                 670         


Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu 
        675                 680                 685             


Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn 
    690                 695                 700                 


Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp 
705                 710                 715                 720 


Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln 
                725                 730                 735     


Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp 
            740                 745                 750         


Val Tyr Arg Val Thr Ser Gly Gly 
        755                 760 


<210>  5
<211>  2283
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(2280)
<223>  rel-Allel

<220>
<221>  mutation
<222>  (113)..(113)
<223>  C -> T Transition

<220>
<221>  misc_feature
<222>  (785)..(785)
<223>  Guanin

<400>  5
atg agt ctg gag cgc aac aca caa aaa tct tcc atg ggt gtg cga agc       48
Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser         
1               5                   10                  15              

atg tca gcc agg ctt gcc cgc agc ctc aca gga aac cgc gtt cgc acc       96
Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr         
            20                  25                  30                  

aac cct gtg ctg gat ctg ctg ctg agc atc cac cgg caa ttt cac cca      144
Asn Pro Val Leu Asp Leu Leu Leu Ser Ile His Arg Gln Phe His Pro         
        35                  40                  45                      

cgc gcc gac gta caa gtg ttg gaa cgt gca tat gac acc gcg gaa cgt      192
Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg         
    50                  55                  60                          

ctt cat gat ggt gtg att cga aaa tcg ggc gat ccg tat att acc cac      240
Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His         
65                  70                  75                  80          

ccg ttg gct gtc gcc acc atc gcc gcg gaa atc ggc atg gac acc acc      288
Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr         
                85                  90                  95              

acg ctc gtc gca gcc ttg ttg cat gac acg gtg gaa gac acc gac tac      336
Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr         
            100                 105                 110                 

tct ttg gac gat ctc acc cga gat ttc gga gaa gaa gtt gcc agg ctt      384
Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu         
        115                 120                 125                     

gtc gac ggt gtc acc aag ctc gac aaa gtc gca cta ggt gct gcc gcg      432
Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala         
    130                 135                 140                         

gag gcc gaa acg att cgc aaa atg atc gtc gcc atg agc cag gac ccc      480
Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro         
145                 150                 155                 160         

cgc gtg ctg gtg att aaa gtg gcc gac cgt ttg cac aat atg cgc acc      528
Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr         
                165                 170                 175             

atg cgg ttc ctg ccg ccg gaa aag caa gct aaa aaa gca cgc caa acc      576
Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr         
            180                 185                 190                 

ctt gaa gtg att gct cct ttg gca cac cgc ctg ggc atg gcc agc gtg      624
Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val         
        195                 200                 205                     

aaa tgg gaa ttg gaa gat cta tcc ttt gcc att ttg tac ccc aag aag      672
Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys         
    210                 215                 220                         

tac gaa gag atc gtg cgt ctt gtt gcc gac cgc gcg ccc tct aga gac      720
Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp         
225                 230                 235                 240         

cgg tac ctc aaa gaa att att gat caa gtc acc ggt ggc ttg cgc gaa      768
Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu         
                245                 250                 255             

aac aac atc gcg gca gga gtg ctt ggt cga cca aag cac tac tgg tct      816
Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser         
            260                 265                 270                 

atc tat caa aag atg atc gtt cgc ggt cgt gat ttt gac gat att ttt      864
Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe         
        275                 280                 285                     

gat ctt gtt ggc atc cgc atc ctg gta gac aac gtg aac aac tgt tac      912
Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr         
    290                 295                 300                         

gcc gcc atc ggt gtc gtg cac tcc ctg ttc aat gct ctg cct ggc cga      960
Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg         
305                 310                 315                 320         

ttc aaa gac tat att tca gcc ccg cgc ttc ggt gtc tac caa tcc ctg     1008
Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu         
                325                 330                 335             

cac acc acc gtg atg gga cct ggc ggt aag cct ctg gaa gtt cag gca     1056
His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala         
            340                 345                 350                 

cgt acc cac gac atg cac tac aac gcc gaa ttc ggc att gca gcg cac     1104
Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His         
        355                 360                 365                     

tgg cga tac aaa gaa acc aaa ggc agc cac agt ggc gag caa gcc gaa     1152
Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu         
    370                 375                 380                         

gtg gat caa atg gcg tgg atg cgc caa ctt ctg gac tgg caa aaa gaa     1200
Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu         
385                 390                 395                 400         

gca gcc gac ccc aac gag ttc ctg gac agc ctg cgc tac gat ctg act     1248
Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr         
                405                 410                 415             

tcc aag cag atc ttc gtg ttc aca ccc aaa ggt gat gtg gtc aac ctg     1296
Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu         
            420                 425                 430                 

ccg gtg aac tcc acc ccg gtg gac ttc gcc tac gcg gtg cac acc gaa     1344
Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu         
        435                 440                 445                     

gtg ggg cac cgc tgc atc ggc gcc aaa atc aac ggc aaa ctg gtc gct     1392
Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala         
    450                 455                 460                         

ttg gaa acg aaa ctc aaa tcc ggc gat cgt gtt gaa gtc ttt acc tcc     1440
Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser         
465                 470                 475                 480         

aag gac caa aac gct ggc cca agt agg gga tgg caa gaa ttt gtt gtc     1488
Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val         
                485                 490                 495             

tca cct cgt gca aag gcc aag att cgc cag tgg ttt gcc aag gaa cga     1536
Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg         
            500                 505                 510                 

cgc gaa gaa tac cta gaa gcc gga cgc gat gcg ctg gca gca gtt att     1584
Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile         
        515                 520                 525                     

cag cgt ggc ggc ctg cca atg cac cgc ttg ttc acc gcg tcc tcc atg     1632
Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met         
    530                 535                 540                         

aag acg gtg gca aca gag ctg cac tac cca gat gta gat gcg ctc tac     1680
Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr         
545                 550                 555                 560         

aca gcc atc ggc tcc ggt tct gta tct gcg caa cac gta gtc aac cgt     1728
Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg         
                565                 570                 575             

ctc atg gct atc ttt ggt gac gaa gaa gat gcc gaa gac gca ttg gtt     1776
Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val         
            580                 585                 590                 

gca cgc acc cca ttc agc gag ctg gtc aac tcc cgt gcc acc acg gaa     1824
Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu         
        595                 600                 605                     

agc agc acc ggc atc ctg gtc gaa ggc agc cca gat gtc atg gct aag     1872
Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys         
    610                 615                 620                         

ctc gct aaa tgc tgt atg cca gtg cca gga gat gaa atc ttt gga ttc     1920
Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe         
625                 630                 635                 640         

gtc acc cgt ggt ggc ggt gtc tcc gta cac cga aca gac tgc acg aat     1968
Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn         
                645                 650                 655             

gtg gaa aag ctc aaa gaa gag cca gaa cgc att gtc tcc gtc tcc tgg     2016
Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp         
            660                 665                 670                 

gct tcg gaa ggt caa ggt tca gta ttc tct gcc aca ctg cag ctt gaa     2064
Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu         
        675                 680                 685                     

gca ctt gat cgc gca ggc ctg ctc ttt gag ctc acc cgc gta atc aac     2112
Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn         
    690                 695                 700                         

gaa caa aag gtc tcc gtt acc gca atg aac tcc cat tgc tca gaa gac     2160
Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp         
705                 710                 715                 720         

cgc gta gcc acc gtg cgc ttc acc ttt gcg gtc tct gac acc aag cag     2208
Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln         
                725                 730                 735             

ttg gga tcc ctg atg aca cag ctg cgc aat gcc gaa gga gtg ttt gat     2256
Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp         
            740                 745                 750                 

gtc tac cga gtg acc tcg ggt ggc tag                                 2283
Val Tyr Arg Val Thr Ser Gly Gly                                         
        755                 760                                         


<210>  6
<211>  760
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  6

Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 
1               5                   10                  15      


Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 
            20                  25                  30          


Asn Pro Val Leu Asp Leu Leu Leu Ser Ile His Arg Gln Phe His Pro 
        35                  40                  45              


Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg 
    50                  55                  60                  


Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 
65                  70                  75                  80  


Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 
                85                  90                  95      


Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr 
            100                 105                 110         


Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu 
        115                 120                 125             


Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala 
    130                 135                 140                 


Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro 
145                 150                 155                 160 


Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr 
                165                 170                 175     


Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr 
            180                 185                 190         


Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val 
        195                 200                 205             


Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys 
    210                 215                 220                 


Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp 
225                 230                 235                 240 


Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu 
                245                 250                 255     


Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser 
            260                 265                 270         


Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe 
        275                 280                 285             


Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr 
    290                 295                 300                 


Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg 
305                 310                 315                 320 


Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu 
                325                 330                 335     


His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala 
            340                 345                 350         


Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His 
        355                 360                 365             


Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu 
    370                 375                 380                 


Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu 
385                 390                 395                 400 


Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr 
                405                 410                 415     


Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu 
            420                 425                 430         


Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu 
        435                 440                 445             


Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala 
    450                 455                 460                 


Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser 
465                 470                 475                 480 


Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val 
                485                 490                 495     


Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg 
            500                 505                 510         


Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile 
        515                 520                 525             


Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met 
    530                 535                 540                 


Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr 
545                 550                 555                 560 


Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg 
                565                 570                 575     


Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val 
            580                 585                 590         


Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu 
        595                 600                 605             


Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys 
    610                 615                 620                 


Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe 
625                 630                 635                 640 


Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn 
                645                 650                 655     


Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp 
            660                 665                 670         


Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu 
        675                 680                 685             


Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn 
    690                 695                 700                 


Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp 
705                 710                 715                 720 


Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln 
                725                 730                 735     


Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp 
            740                 745                 750         


Val Tyr Arg Val Thr Ser Gly Gly 
        755                 760 


<210>  7
<211>  3800
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (751)..(3033)
<223>  rel-Allel

<220>
<221>  mutation
<222>  (863)..(863)
<223>  C -> T Transition

<220>
<221>  misc_feature
<222>  (1535)..(1535)
<223>  Guanin

<400>  7
aggcgcaact gaagaacaat tgtgggctga agtcccatca attccactag cagcgcaacc     60

ccgagtgttt gtgatagatc gcacagtcgg taacgttgtt gttaatacag acctagccgg    120

tatcggatgg aacatgaccg ttggtccaga agtgaggaat aagtagtgag cgaacaagct    180

ctaagcacct tcgacagggc acgtgaggcc ctggacaaga aaacccgata tgtgcaggat    240

ttcccagaaa agggtgtgct ttttgaagac ctcaccccgg tgttgggcga tgcagaatca    300

tttgtggccg tggtggacgc catggctgaa gctgcagaaa aactgaatgc agaaatcatc    360

ggtggcttgg atgcgcgagg attcctcctc ggatctgctg tcgcttacaa actcggccta    420

ggtgtgctgg ctatccgcaa gaagggaaag ctccccccac ctgtggtgac ccaggagtat    480

gaacttgaat acggcactgc agcactcgag ctgcccagtg aaggaatcga cattgctggt    540

aaaaacatcg ttttgatcga cgatgtgctg gcaaccggcg gcaccttggg cgctgcacgt    600

aaactaattg aatcgtgtga cggacatgtt tccggatatg ttcttgccat tgaggtccca    660

ggcctcggcg gtagggataa tcttggtgat aggcccgtca ttgtggtcag agatcctcag    720

tagaaggatc gaaagaaagg cggcaggaaa atg agt ctg gag cgc aac aca caa     774
                                 Met Ser Leu Glu Arg Asn Thr Gln        
                                 1               5                      

aaa tct tcc atg ggt gtg cga agc atg tca gcc agg ctt gcc cgc agc      822
Lys Ser Ser Met Gly Val Arg Ser Met Ser Ala Arg Leu Ala Arg Ser         
    10                  15                  20                          

ctc aca gga aac cgc gtt cgc acc aac cct gtg ctg gat ctg ctg ctg      870
Leu Thr Gly Asn Arg Val Arg Thr Asn Pro Val Leu Asp Leu Leu Leu         
25                  30                  35                  40          

agc atc cac cgg caa ttt cac cca cgc gcc gac gta caa gtg ttg gaa      918
Ser Ile His Arg Gln Phe His Pro Arg Ala Asp Val Gln Val Leu Glu         
                45                  50                  55              

cgt gca tat gac acc gcg gaa cgt ctt cat gat ggt gtg att cga aaa      966
Arg Ala Tyr Asp Thr Ala Glu Arg Leu His Asp Gly Val Ile Arg Lys         
            60                  65                  70                  

tcg ggc gat ccg tat att acc cac ccg ttg gct gtc gcc acc atc gcc     1014
Ser Gly Asp Pro Tyr Ile Thr His Pro Leu Ala Val Ala Thr Ile Ala         
        75                  80                  85                      

gcg gaa atc ggc atg gac acc acc acg ctc gtc gca gcc ttg ttg cat     1062
Ala Glu Ile Gly Met Asp Thr Thr Thr Leu Val Ala Ala Leu Leu His         
    90                  95                  100                         

gac acg gtg gaa gac acc gac tac tct ttg gac gat ctc acc cga gat     1110
Asp Thr Val Glu Asp Thr Asp Tyr Ser Leu Asp Asp Leu Thr Arg Asp         
105                 110                 115                 120         

ttc gga gaa gaa gtt gcc agg ctt gtc gac ggt gtc acc aag ctc gac     1158
Phe Gly Glu Glu Val Ala Arg Leu Val Asp Gly Val Thr Lys Leu Asp         
                125                 130                 135             

aaa gtc gca cta ggt gct gcc gcg gag gcc gaa acg att cgc aaa atg     1206
Lys Val Ala Leu Gly Ala Ala Ala Glu Ala Glu Thr Ile Arg Lys Met         
            140                 145                 150                 

atc gtc gcc atg agc cag gac ccc cgc gtg ctg gtg att aaa gtg gcc     1254
Ile Val Ala Met Ser Gln Asp Pro Arg Val Leu Val Ile Lys Val Ala         
        155                 160                 165                     

gac cgt ttg cac aat atg cgc acc atg cgg ttc ctg ccg ccg gaa aag     1302
Asp Arg Leu His Asn Met Arg Thr Met Arg Phe Leu Pro Pro Glu Lys         
    170                 175                 180                         

caa gct aaa aaa gca cgc caa acc ctt gaa gtg att gct cct ttg gca     1350
Gln Ala Lys Lys Ala Arg Gln Thr Leu Glu Val Ile Ala Pro Leu Ala         
185                 190                 195                 200         

cac cgc ctg ggc atg gcc agc gtg aaa tgg gaa ttg gaa gat cta tcc     1398
His Arg Leu Gly Met Ala Ser Val Lys Trp Glu Leu Glu Asp Leu Ser         
                205                 210                 215             

ttt gcc att ttg tac ccc aag aag tac gaa gag atc gtg cgt ctt gtt     1446
Phe Ala Ile Leu Tyr Pro Lys Lys Tyr Glu Glu Ile Val Arg Leu Val         
            220                 225                 230                 

gcc gac cgc gcg ccc tct aga gac cgg tac ctc aaa gaa att att gat     1494
Ala Asp Arg Ala Pro Ser Arg Asp Arg Tyr Leu Lys Glu Ile Ile Asp         
        235                 240                 245                     

caa gtc acc ggt ggc ttg cgc gaa aac aac atc gcg gca gga gtg ctt     1542
Gln Val Thr Gly Gly Leu Arg Glu Asn Asn Ile Ala Ala Gly Val Leu         
    250                 255                 260                         

ggt cga cca aag cac tac tgg tct atc tat caa aag atg atc gtt cgc     1590
Gly Arg Pro Lys His Tyr Trp Ser Ile Tyr Gln Lys Met Ile Val Arg         
265                 270                 275                 280         

ggt cgt gat ttt gac gat att ttt gat ctt gtt ggc atc cgc atc ctg     1638
Gly Arg Asp Phe Asp Asp Ile Phe Asp Leu Val Gly Ile Arg Ile Leu         
                285                 290                 295             

gta gac aac gtg aac aac tgt tac gcc gcc atc ggt gtc gtg cac tcc     1686
Val Asp Asn Val Asn Asn Cys Tyr Ala Ala Ile Gly Val Val His Ser         
            300                 305                 310                 

ctg ttc aat gct ctg cct ggc cga ttc aaa gac tat att tca gcc ccg     1734
Leu Phe Asn Ala Leu Pro Gly Arg Phe Lys Asp Tyr Ile Ser Ala Pro         
        315                 320                 325                     

cgc ttc ggt gtc tac caa tcc ctg cac acc acc gtg atg gga cct ggc     1782
Arg Phe Gly Val Tyr Gln Ser Leu His Thr Thr Val Met Gly Pro Gly         
    330                 335                 340                         

ggt aag cct ctg gaa gtt cag gca cgt acc cac gac atg cac tac aac     1830
Gly Lys Pro Leu Glu Val Gln Ala Arg Thr His Asp Met His Tyr Asn         
345                 350                 355                 360         

gcc gaa ttc ggc att gca gcg cac tgg cga tac aaa gaa acc aaa ggc     1878
Ala Glu Phe Gly Ile Ala Ala His Trp Arg Tyr Lys Glu Thr Lys Gly         
                365                 370                 375             

agc cac agt ggc gag caa gcc gaa gtg gat caa atg gcg tgg atg cgc     1926
Ser His Ser Gly Glu Gln Ala Glu Val Asp Gln Met Ala Trp Met Arg         
            380                 385                 390                 

caa ctt ctg gac tgg caa aaa gaa gca gcc gac ccc aac gag ttc ctg     1974
Gln Leu Leu Asp Trp Gln Lys Glu Ala Ala Asp Pro Asn Glu Phe Leu         
        395                 400                 405                     

gac agc ctg cgc tac gat ctg act tcc aag cag atc ttc gtg ttc aca     2022
Asp Ser Leu Arg Tyr Asp Leu Thr Ser Lys Gln Ile Phe Val Phe Thr         
    410                 415                 420                         

ccc aaa ggt gat gtg gtc aac ctg ccg gtg aac tcc acc ccg gtg gac     2070
Pro Lys Gly Asp Val Val Asn Leu Pro Val Asn Ser Thr Pro Val Asp         
425                 430                 435                 440         

ttc gcc tac gcg gtg cac acc gaa gtg ggg cac cgc tgc atc ggc gcc     2118
Phe Ala Tyr Ala Val His Thr Glu Val Gly His Arg Cys Ile Gly Ala         
                445                 450                 455             

aaa atc aac ggc aaa ctg gtc gct ttg gaa acg aaa ctc aaa tcc ggc     2166
Lys Ile Asn Gly Lys Leu Val Ala Leu Glu Thr Lys Leu Lys Ser Gly         
            460                 465                 470                 

gat cgt gtt gaa gtc ttt acc tcc aag gac caa aac gct ggc cca agt     2214
Asp Arg Val Glu Val Phe Thr Ser Lys Asp Gln Asn Ala Gly Pro Ser         
        475                 480                 485                     

agg gga tgg caa gaa ttt gtt gtc tca cct cgt gca aag gcc aag att     2262
Arg Gly Trp Gln Glu Phe Val Val Ser Pro Arg Ala Lys Ala Lys Ile         
    490                 495                 500                         

cgc cag tgg ttt gcc aag gaa cga cgc gaa gaa tac cta gaa gcc gga     2310
Arg Gln Trp Phe Ala Lys Glu Arg Arg Glu Glu Tyr Leu Glu Ala Gly         
505                 510                 515                 520         

cgc gat gcg ctg gca gca gtt att cag cgt ggc ggc ctg cca atg cac     2358
Arg Asp Ala Leu Ala Ala Val Ile Gln Arg Gly Gly Leu Pro Met His         
                525                 530                 535             

cgc ttg ttc acc gcg tcc tcc atg aag acg gtg gca aca gag ctg cac     2406
Arg Leu Phe Thr Ala Ser Ser Met Lys Thr Val Ala Thr Glu Leu His         
            540                 545                 550                 

tac cca gat gta gat gcg ctc tac aca gcc atc ggc tcc ggt tct gta     2454
Tyr Pro Asp Val Asp Ala Leu Tyr Thr Ala Ile Gly Ser Gly Ser Val         
        555                 560                 565                     

tct gcg caa cac gta gtc aac cgt ctc atg gct atc ttt ggt gac gaa     2502
Ser Ala Gln His Val Val Asn Arg Leu Met Ala Ile Phe Gly Asp Glu         
    570                 575                 580                         

gaa gat gcc gaa gac gca ttg gtt gca cgc acc cca ttc agc gag ctg     2550
Glu Asp Ala Glu Asp Ala Leu Val Ala Arg Thr Pro Phe Ser Glu Leu         
585                 590                 595                 600         

gtc aac tcc cgt gcc acc acg gaa agc agc acc ggc atc ctg gtc gaa     2598
Val Asn Ser Arg Ala Thr Thr Glu Ser Ser Thr Gly Ile Leu Val Glu         
                605                 610                 615             

ggc agc cca gat gtc atg gct aag ctc gct aaa tgc tgt atg cca gtg     2646
Gly Ser Pro Asp Val Met Ala Lys Leu Ala Lys Cys Cys Met Pro Val         
            620                 625                 630                 

cca gga gat gaa atc ttt gga ttc gtc acc cgt ggt ggc ggt gtc tcc     2694
Pro Gly Asp Glu Ile Phe Gly Phe Val Thr Arg Gly Gly Gly Val Ser         
        635                 640                 645                     

gta cac cga aca gac tgc acg aat gtg gaa aag ctc aaa gaa gag cca     2742
Val His Arg Thr Asp Cys Thr Asn Val Glu Lys Leu Lys Glu Glu Pro         
    650                 655                 660                         

gaa cgc att gtc tcc gtc tcc tgg gct tcg gaa ggt caa ggt tca gta     2790
Glu Arg Ile Val Ser Val Ser Trp Ala Ser Glu Gly Gln Gly Ser Val         
665                 670                 675                 680         

ttc tct gcc aca ctg cag ctt gaa gca ctt gat cgc gca ggc ctg ctc     2838
Phe Ser Ala Thr Leu Gln Leu Glu Ala Leu Asp Arg Ala Gly Leu Leu         
                685                 690                 695             

ttt gag ctc acc cgc gta atc aac gaa caa aag gtc tcc gtt acc gca     2886
Phe Glu Leu Thr Arg Val Ile Asn Glu Gln Lys Val Ser Val Thr Ala         
            700                 705                 710                 

atg aac tcc cat tgc tca gaa gac cgc gta gcc acc gtg cgc ttc acc     2934
Met Asn Ser His Cys Ser Glu Asp Arg Val Ala Thr Val Arg Phe Thr         
        715                 720                 725                     

ttt gcg gtc tct gac acc aag cag ttg gga tcc ctg atg aca cag ctg     2982
Phe Ala Val Ser Asp Thr Lys Gln Leu Gly Ser Leu Met Thr Gln Leu         
    730                 735                 740                         

cgc aat gcc gaa gga gtg ttt gat gtc tac cga gtg acc tcg ggt ggc     3030
Arg Asn Ala Glu Gly Val Phe Asp Val Tyr Arg Val Thr Ser Gly Gly         
745                 750                 755                 760         

tag aggcctttag attgtgaaaa agccttgggc ttcaaccacc gtgtgttgac          3083

acggttttgg ggttggattt aacgctggaa attttactgc aatgaacgct ggaaagcagt   3143

agcgaaggtc aaaccagcgc tgaggacgcc aacgatgcca gtaataacga cgacgtaatc   3203

caaaatggtg tcagagtcaa tgtcagaaga tccgttggtg ctaccgtttc ttcttctacg   3263

gtgtcagcca cgtacacaac ctgtgctggt gcgacttctt cagcctgtgc aggaacggag   3323

atggaggttg ctgccattgc agcagctgtg ccgagtgcga cgaggggagt acgagaaaat   3383

agcttcattg ctaaacccct taggtttaaa tattcgaata cgaaagttac tttatgtgca   3443

ctttcaccat tgtgcaacta tatgtgcagg tcaaagctga tattttgcta agaaaagtgc   3503

aaagcgattc gagctgacgc gcagcccata tcgtcaaaaa atcctttgtg aatggtgatt   3563

cacaaaggat tagtcgcgta aggcggaaat tacttcagga aggaatccag cttggtactg   3623

aaggttaaaa tggtggttag tgcaccgatg actgctgtga tgatcttgat ccagttttcg   3683

atgttgtcag tgtcggaaga accgctggaa ggctcttcgc tggacgggtc ttcgttgaaa   3743

tcaaagttaa cgtaaacttc tgcttcaacg cctgcttcgt tcttggcaat gatcttt      3800


<210>  8
<211>  760
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  8

Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 
1               5                   10                  15      


Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 
            20                  25                  30          


Asn Pro Val Leu Asp Leu Leu Leu Ser Ile His Arg Gln Phe His Pro 
        35                  40                  45              


Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg 
    50                  55                  60                  


Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 
65                  70                  75                  80  


Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 
                85                  90                  95      


Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr 
            100                 105                 110         


Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu 
        115                 120                 125             


Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala 
    130                 135                 140                 


Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro 
145                 150                 155                 160 


Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr 
                165                 170                 175     


Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr 
            180                 185                 190         


Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val 
        195                 200                 205             


Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys 
    210                 215                 220                 


Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp 
225                 230                 235                 240 


Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu 
                245                 250                 255     


Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser 
            260                 265                 270         


Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe 
        275                 280                 285             


Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr 
    290                 295                 300                 


Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg 
305                 310                 315                 320 


Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu 
                325                 330                 335     


His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala 
            340                 345                 350         


Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His 
        355                 360                 365             


Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu 
    370                 375                 380                 


Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu 
385                 390                 395                 400 


Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr 
                405                 410                 415     


Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu 
            420                 425                 430         


Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu 
        435                 440                 445             


Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala 
    450                 455                 460                 


Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser 
465                 470                 475                 480 


Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val 
                485                 490                 495     


Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg 
            500                 505                 510         


Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile 
        515                 520                 525             


Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met 
    530                 535                 540                 


Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr 
545                 550                 555                 560 


Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg 
                565                 570                 575     


Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val 
            580                 585                 590         


Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu 
        595                 600                 605             


Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys 
    610                 615                 620                 


Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe 
625                 630                 635                 640 


Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn 
                645                 650                 655     


Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp 
            660                 665                 670         


Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu 
        675                 680                 685             


Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn 
    690                 695                 700                 


Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp 
705                 710                 715                 720 


Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln 
                725                 730                 735     


Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp 
            740                 745                 750         


Val Tyr Arg Val Thr Ser Gly Gly 
        755                 760 


<210>  9
<211>  1263
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(1263)
<223>  lysC-Wildtyp-Gen

<400>  9
gtg gcc ctg gtc gta cag aaa tat ggc ggt tcc tcg ctt gag agt gcg       48
Met Ala Leu Val Val Gln Lys Tyr Gly Gly Ser Ser Leu Glu Ser Ala         
1               5                   10                  15              

gaa cgc att aga aac gtc gct gaa cgg atc gtt gcc acc aag aag gct       96
Glu Arg Ile Arg Asn Val Ala Glu Arg Ile Val Ala Thr Lys Lys Ala         
            20                  25                  30                  

gga aat gat gtc gtg gtt gtc tgc tcc gca atg gga gac acc acg gat      144
Gly Asn Asp Val Val Val Val Cys Ser Ala Met Gly Asp Thr Thr Asp         
        35                  40                  45                      

gaa ctt cta gaa ctt gca gcg gca gtg aat ccc gtt ccg cca gct cgt      192
Glu Leu Leu Glu Leu Ala Ala Ala Val Asn Pro Val Pro Pro Ala Arg         
    50                  55                  60                          

gaa atg gat atg ctc ctg act gct ggt gag cgt att tct aac gct ctc      240
Glu Met Asp Met Leu Leu Thr Ala Gly Glu Arg Ile Ser Asn Ala Leu         
65                  70                  75                  80          

gtc gcc atg gct att gag tcc ctt ggc gca gaa gcc caa tct ttc acg      288
Val Ala Met Ala Ile Glu Ser Leu Gly Ala Glu Ala Gln Ser Phe Thr         
                85                  90                  95              

ggc tct cag gct ggt gtg ctc acc acc gag cgc cac gga aac gca cgc      336
Gly Ser Gln Ala Gly Val Leu Thr Thr Glu Arg His Gly Asn Ala Arg         
            100                 105                 110                 

att gtt gat gtc act cca ggt cgt gtg cgt gaa gca ctc gat gag ggc      384
Ile Val Asp Val Thr Pro Gly Arg Val Arg Glu Ala Leu Asp Glu Gly         
        115                 120                 125                     

aag atc tgc att gtt gct ggt ttc cag ggt gtt aat aaa gaa acc cgc      432
Lys Ile Cys Ile Val Ala Gly Phe Gln Gly Val Asn Lys Glu Thr Arg         
    130                 135                 140                         

gat gtc acc acg ttg ggt cgt ggt ggt tct gac acc act gca gtt gcg      480
Asp Val Thr Thr Leu Gly Arg Gly Gly Ser Asp Thr Thr Ala Val Ala         
145                 150                 155                 160         

ttg gca gct gct ttg aac gct gat gtg tgt gag att tac tcg gac gtt      528
Leu Ala Ala Ala Leu Asn Ala Asp Val Cys Glu Ile Tyr Ser Asp Val         
                165                 170                 175             

gac ggt gtg tat acc gct gac ccg cgc atc gtt cct aat gca cag aag      576
Asp Gly Val Tyr Thr Ala Asp Pro Arg Ile Val Pro Asn Ala Gln Lys         
            180                 185                 190                 

ctg gaa aag ctc agc ttc gaa gaa atg ctg gaa ctt gct gct gtt ggc      624
Leu Glu Lys Leu Ser Phe Glu Glu Met Leu Glu Leu Ala Ala Val Gly         
        195                 200                 205                     

tcc aag att ttg gtg ctg cgc agt gtt gaa tac gct cgt gca ttc aat      672
Ser Lys Ile Leu Val Leu Arg Ser Val Glu Tyr Ala Arg Ala Phe Asn         
    210                 215                 220                         

gtg cca ctt cgc gta cgc tcg tct tat agt aat gat ccc ggc act ttg      720
Val Pro Leu Arg Val Arg Ser Ser Tyr Ser Asn Asp Pro Gly Thr Leu         
225                 230                 235                 240         

att gcc ggc tct atg gag gat att cct gtg gaa gaa gca gtc ctt acc      768
Ile Ala Gly Ser Met Glu Asp Ile Pro Val Glu Glu Ala Val Leu Thr         
                245                 250                 255             

ggt gtc gca acc gac aag tcc gaa gcc aaa gta acc gtt ctg ggt att      816
Gly Val Ala Thr Asp Lys Ser Glu Ala Lys Val Thr Val Leu Gly Ile         
            260                 265                 270                 

tcc gat aag cca ggc gag gct gcg aag gtt ttc cgt gcg ttg gct gat      864
Ser Asp Lys Pro Gly Glu Ala Ala Lys Val Phe Arg Ala Leu Ala Asp         
        275                 280                 285                     

gca gaa atc aac att gac atg gtt ctg cag aac gtc tct tct gta gaa      912
Ala Glu Ile Asn Ile Asp Met Val Leu Gln Asn Val Ser Ser Val Glu         
    290                 295                 300                         

gac ggc acc acc gac atc acc ttc acc tgc cct cgt tcc gac ggc cgc      960
Asp Gly Thr Thr Asp Ile Thr Phe Thr Cys Pro Arg Ser Asp Gly Arg         
305                 310                 315                 320         

cgc gcg atg gag atc ttg aag aag ctt cag gtt cag ggc aac tgg acc     1008
Arg Ala Met Glu Ile Leu Lys Lys Leu Gln Val Gln Gly Asn Trp Thr         
                325                 330                 335             

aat gtg ctt tac gac gac cag gtc ggc aaa gtc tcc ctc gtg ggt gct     1056
Asn Val Leu Tyr Asp Asp Gln Val Gly Lys Val Ser Leu Val Gly Ala         
            340                 345                 350                 

ggc atg aag tct cac cca ggt gtt acc gca gag ttc atg gaa gct ctg     1104
Gly Met Lys Ser His Pro Gly Val Thr Ala Glu Phe Met Glu Ala Leu         
        355                 360                 365                     

cgc gat gtc aac gtg aac atc gaa ttg att tcc acc tct gag att cgt     1152
Arg Asp Val Asn Val Asn Ile Glu Leu Ile Ser Thr Ser Glu Ile Arg         
    370                 375                 380                         

att tcc gtg ctg atc cgt gaa gat gat ctg gat gct gct gca cgt gca     1200
Ile Ser Val Leu Ile Arg Glu Asp Asp Leu Asp Ala Ala Ala Arg Ala         
385                 390                 395                 400         

ttg cat gag cag ttc cag ctg ggc ggc gaa gac gaa gcc gtc gtt tat     1248
Leu His Glu Gln Phe Gln Leu Gly Gly Glu Asp Glu Ala Val Val Tyr         
                405                 410                 415             

gca ggc acc gga cgc                                                 1263
Ala Gly Thr Gly Arg                                                     
            420                                                         


<210>  10
<211>  421
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  10

Met Ala Leu Val Val Gln Lys Tyr Gly Gly Ser Ser Leu Glu Ser Ala 
1               5                   10                  15      


Glu Arg Ile Arg Asn Val Ala Glu Arg Ile Val Ala Thr Lys Lys Ala 
            20                  25                  30          


Gly Asn Asp Val Val Val Val Cys Ser Ala Met Gly Asp Thr Thr Asp 
        35                  40                  45              


Glu Leu Leu Glu Leu Ala Ala Ala Val Asn Pro Val Pro Pro Ala Arg 
    50                  55                  60                  


Glu Met Asp Met Leu Leu Thr Ala Gly Glu Arg Ile Ser Asn Ala Leu 
65                  70                  75                  80  


Val Ala Met Ala Ile Glu Ser Leu Gly Ala Glu Ala Gln Ser Phe Thr 
                85                  90                  95      


Gly Ser Gln Ala Gly Val Leu Thr Thr Glu Arg His Gly Asn Ala Arg 
            100                 105                 110         


Ile Val Asp Val Thr Pro Gly Arg Val Arg Glu Ala Leu Asp Glu Gly 
        115                 120                 125             


Lys Ile Cys Ile Val Ala Gly Phe Gln Gly Val Asn Lys Glu Thr Arg 
    130                 135                 140                 


Asp Val Thr Thr Leu Gly Arg Gly Gly Ser Asp Thr Thr Ala Val Ala 
145                 150                 155                 160 


Leu Ala Ala Ala Leu Asn Ala Asp Val Cys Glu Ile Tyr Ser Asp Val 
                165                 170                 175     


Asp Gly Val Tyr Thr Ala Asp Pro Arg Ile Val Pro Asn Ala Gln Lys 
            180                 185                 190         


Leu Glu Lys Leu Ser Phe Glu Glu Met Leu Glu Leu Ala Ala Val Gly 
        195                 200                 205             


Ser Lys Ile Leu Val Leu Arg Ser Val Glu Tyr Ala Arg Ala Phe Asn 
    210                 215                 220                 


Val Pro Leu Arg Val Arg Ser Ser Tyr Ser Asn Asp Pro Gly Thr Leu 
225                 230                 235                 240 


Ile Ala Gly Ser Met Glu Asp Ile Pro Val Glu Glu Ala Val Leu Thr 
                245                 250                 255     


Gly Val Ala Thr Asp Lys Ser Glu Ala Lys Val Thr Val Leu Gly Ile 
            260                 265                 270         


Ser Asp Lys Pro Gly Glu Ala Ala Lys Val Phe Arg Ala Leu Ala Asp 
        275                 280                 285             


Ala Glu Ile Asn Ile Asp Met Val Leu Gln Asn Val Ser Ser Val Glu 
    290                 295                 300                 


Asp Gly Thr Thr Asp Ile Thr Phe Thr Cys Pro Arg Ser Asp Gly Arg 
305                 310                 315                 320 


Arg Ala Met Glu Ile Leu Lys Lys Leu Gln Val Gln Gly Asn Trp Thr 
                325                 330                 335     


Asn Val Leu Tyr Asp Asp Gln Val Gly Lys Val Ser Leu Val Gly Ala 
            340                 345                 350         


Gly Met Lys Ser His Pro Gly Val Thr Ala Glu Phe Met Glu Ala Leu 
        355                 360                 365             


Arg Asp Val Asn Val Asn Ile Glu Leu Ile Ser Thr Ser Glu Ile Arg 
    370                 375                 380                 


Ile Ser Val Leu Ile Arg Glu Asp Asp Leu Asp Ala Ala Ala Arg Ala 
385                 390                 395                 400 


Leu His Glu Gln Phe Gln Leu Gly Gly Glu Asp Glu Ala Val Val Tyr 
                405                 410                 415     


Ala Gly Thr Gly Arg 
            420     


<210>  11
<211>  117
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(117)

<220>
<221>  misc_feature
<222>  (58)..(60)
<223>  n is a, c, g, or t

<400>  11
gcc agg ctt gcc cgc agc ctc aca gga aac cgc gtt cgc acc aac cct       48
Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro         
1               5                   10                  15              

gtg ctg gat nnn ctg ctg agc atc cac cgg caa ttt cac cca cgc gcc       96
Val Leu Asp Xaa Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala         
            20                  25                  30                  

gac gta caa gtg ttg gaa cgt                                          117
Asp Val Gln Val Leu Glu Arg                                             
        35                                                              


<210>  12
<211>  39
<212>  PRT
<213>  Corynebacterium glutamicum

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  The 'Xaa' at location 20 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Leu, Tyr, Trp, Cys, 
       or Phe.

<400>  12

Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro 
1               5                   10                  15      


Val Leu Asp Xaa Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala 
            20                  25                  30          


Asp Val Gln Val Leu Glu Arg 
        35                  


<210>  13
<211>  117
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(117)

<400>  13
gcc agg ctt gcc cgc agc ctc aca gga aac cgc gtt cgc acc aac cct       48
Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro         
1               5                   10                  15              

gtg ctg gat ctg ctg ctg agc atc cac cgg caa ttt cac cca cgc gcc       96
Val Leu Asp Leu Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala         
            20                  25                  30                  

gac gta caa gtg ttg gaa cgt                                          117
Asp Val Gln Val Leu Glu Arg                                             
        35                                                              


<210>  14
<211>  39
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  14

Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro 
1               5                   10                  15      


Val Leu Asp Leu Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala 
            20                  25                  30          


Asp Val Gln Val Leu Glu Arg 
        35                  


<210>  15
<211>  1530
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  misc_feature
<222>  (1)..(2)

<220>
<221>  misc_structure
<222>  (3)..(8)
<223>  EcoRI-Restriktionsschnittstelle

<220>
<221>  CDS
<222>  (639)..(1520)

<220>
<221>  mutation
<222>  (751)..(751)

<220>
<221>  misc_feature
<222>  (1423)..(1423)
<223>  Guanin

<220>
<221>  misc_structure
<222>  (1523)..(1528)
<223>  EcoRI-Restriktionsschnittstelle

<220>
<221>  misc_feature
<222>  (1529)..(1530)

<400>  15
gcgaattcta tcggatggaa catgaccgtt ggtccagaag tgaggaataa gtagtgagcg     60

aacaagctct aagcaccttc gacagggcac gtgaggccct ggacaagaaa acccgatatg    120

tgcaggattt cccagaaaag ggtgtgcttt ttgaagacct caccccggtg ttgggcgatg    180

cagaatcatt tgtggccgtg gtggacgcca tggctgaagc tgcagaaaaa ctgaatgcag    240

aaatcatcgg tggcttggat gcgcgaggat tcctcctcgg atctgctgtc gcttacaaac    300

tcggcctagg tgtgctggct atccgcaaga agggaaagct ccccccacct gtggtgaccc    360

aggagtatga acttgaatac ggcactgcag cactcgagct gcccagtgaa ggaatcgaca    420

ttgctggtaa aaacatcgtt ttgatcgacg atgtgctggc aaccggcggc accttgggcg    480

ctgcacgtaa actaattgaa tcgtgtgacg gacatgtttc cggatatgtt cttgccattg    540

aggtcccagg cctcggcggt agggataatc ttggtgatag gcccgtcatt gtggtcagag    600

atcctcagta gaaggatcga aagaaaggcg gcaggaaa atg agt ctg gag cgc aac    656
                                          Met Ser Leu Glu Arg Asn       
                                          1               5             

aca caa aaa tct tcc atg ggt gtg cga agc atg tca gcc agg ctt gcc      704
Thr Gln Lys Ser Ser Met Gly Val Arg Ser Met Ser Ala Arg Leu Ala         
            10                  15                  20                  

cgc agc ctc aca gga aac cgc gtt cgc acc aac cct gtg ctg gat ctg      752
Arg Ser Leu Thr Gly Asn Arg Val Arg Thr Asn Pro Val Leu Asp Leu         
        25                  30                  35                      

ctg ctg agc atc cac cgg caa ttt cac cca cgc gcc gac gta caa gtg      800
Leu Leu Ser Ile His Arg Gln Phe His Pro Arg Ala Asp Val Gln Val         
    40                  45                  50                          

ttg gaa cgt gca tat gac acc gcg gaa cgt ctt cat gat ggt gtg att      848
Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg Leu His Asp Gly Val Ile         
55                  60                  65                  70          

cga aaa tcg ggc gat ccg tat att acc cac ccg ttg gct gtc gcc acc      896
Arg Lys Ser Gly Asp Pro Tyr Ile Thr His Pro Leu Ala Val Ala Thr         
                75                  80                  85              

atc gcc gcg gaa atc ggc atg gac acc acc acg ctc gtc gca gcc ttg      944
Ile Ala Ala Glu Ile Gly Met Asp Thr Thr Thr Leu Val Ala Ala Leu         
            90                  95                  100                 

ttg cat gac acg gtg gaa gac acc gac tac tct ttg gac gat ctc acc      992
Leu His Asp Thr Val Glu Asp Thr Asp Tyr Ser Leu Asp Asp Leu Thr         
        105                 110                 115                     

cga gat ttc gga gaa gaa gtt gcc agg ctt gtc gac ggt gtc acc aag     1040
Arg Asp Phe Gly Glu Glu Val Ala Arg Leu Val Asp Gly Val Thr Lys         
    120                 125                 130                         

ctc gac aaa gtc gca cta ggt gct gcc gcg gag gcc gaa acg att cgc     1088
Leu Asp Lys Val Ala Leu Gly Ala Ala Ala Glu Ala Glu Thr Ile Arg         
135                 140                 145                 150         

aaa atg atc gtc gcc atg agc cag gac ccc cgc gtg ctg gtg att aaa     1136
Lys Met Ile Val Ala Met Ser Gln Asp Pro Arg Val Leu Val Ile Lys         
                155                 160                 165             

gtg gcc gac cgt ttg cac aat atg cgc acc atg cgg ttc ctg ccg ccg     1184
Val Ala Asp Arg Leu His Asn Met Arg Thr Met Arg Phe Leu Pro Pro         
            170                 175                 180                 

gaa aag caa gct aaa aaa gca cgc caa acc ctt gaa gtg att gct cct     1232
Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr Leu Glu Val Ile Ala Pro         
        185                 190                 195                     

ttg gca cac cgc ctg ggc atg gcc agc gtg aaa tgg gaa ttg gaa gat     1280
Leu Ala His Arg Leu Gly Met Ala Ser Val Lys Trp Glu Leu Glu Asp         
    200                 205                 210                         

cta tcc ttt gcc att ttg tac ccc aag aag tac gaa gag atc gtg cgt     1328
Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys Tyr Glu Glu Ile Val Arg         
215                 220                 225                 230         

ctt gtt gcc gac cgc gcg ccc tct aga gac cgg tac ctc aaa gaa att     1376
Leu Val Ala Asp Arg Ala Pro Ser Arg Asp Arg Tyr Leu Lys Glu Ile         
                235                 240                 245             

att gat caa gtc acc ggt ggc ttg cgc gaa aac aac atc gcg gca gga     1424
Ile Asp Gln Val Thr Gly Gly Leu Arg Glu Asn Asn Ile Ala Ala Gly         
            250                 255                 260                 

gtg ctt ggt cga cca aag cac tac tgg tct atc tat caa aag atg atc     1472
Val Leu Gly Arg Pro Lys His Tyr Trp Ser Ile Tyr Gln Lys Met Ile         
        265                 270                 275                     

gtt cgc ggt cgt gat ttt gac gat att ttt gat ctt gtt ggc atc cgc     1520
Val Arg Gly Arg Asp Phe Asp Asp Ile Phe Asp Leu Val Gly Ile Arg         
    280                 285                 290                         

atgaattcgc                                                          1530


<210>  16
<211>  294
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  16

Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 
1               5                   10                  15      


Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 
            20                  25                  30          


Asn Pro Val Leu Asp Leu Leu Leu Ser Ile His Arg Gln Phe His Pro 
        35                  40                  45              


Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg 
    50                  55                  60                  


Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 
65                  70                  75                  80  


Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 
                85                  90                  95      


Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr 
            100                 105                 110         


Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu 
        115                 120                 125             


Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala 
    130                 135                 140                 


Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro 
145                 150                 155                 160 


Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr 
                165                 170                 175     


Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr 
            180                 185                 190         


Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val 
        195                 200                 205             


Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys 
    210                 215                 220                 


Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp 
225                 230                 235                 240 


Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu 
                245                 250                 255     


Asn Asn Ile Ala Ala Gly Val Leu Gly Arg Pro Lys His Tyr Trp Ser 
            260                 265                 270         


Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe 
        275                 280                 285             


Asp Leu Val Gly Ile Arg 
    290                 


<210>  17
<211>  1311
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(1308)
<223>  ilvA-Wildtyp-Gen

<400>  17
atg agt gaa aca tac gtg tct gag aaa agt cca gga gtg atg gct agc       48
Met Ser Glu Thr Tyr Val Ser Glu Lys Ser Pro Gly Val Met Ala Ser         
1               5                   10                  15              

gga gcg gag ctg att cgt gcc gcc gac att caa acg gcg cag gca cga       96
Gly Ala Glu Leu Ile Arg Ala Ala Asp Ile Gln Thr Ala Gln Ala Arg         
            20                  25                  30                  

att tcc tcc gtc att gca cca act cca ttg cag tat tgc cct cgt ctt      144
Ile Ser Ser Val Ile Ala Pro Thr Pro Leu Gln Tyr Cys Pro Arg Leu         
        35                  40                  45                      

tct gag gaa acc gga gcg gaa atc tac ctt aag cgt gag gat ctg cag      192
Ser Glu Glu Thr Gly Ala Glu Ile Tyr Leu Lys Arg Glu Asp Leu Gln         
    50                  55                  60                          

gat gtt cgt tcc tac aag atc cgc ggt gcg ctg aac tct gga gcg cag      240
Asp Val Arg Ser Tyr Lys Ile Arg Gly Ala Leu Asn Ser Gly Ala Gln         
65                  70                  75                  80          

ctc acc caa gag cag cgc gat gca ggt atc gtt gcc gca tct gca ggt      288
Leu Thr Gln Glu Gln Arg Asp Ala Gly Ile Val Ala Ala Ser Ala Gly         
                85                  90                  95              

aac cat gcc cag ggc gtg gcc tat gtg tgc aag tcc ttg ggc gtt cag      336
Asn His Ala Gln Gly Val Ala Tyr Val Cys Lys Ser Leu Gly Val Gln         
            100                 105                 110                 

gga cgc atc tat gtt cct gtg cag act cca aag caa aag cgt gac cgc      384
Gly Arg Ile Tyr Val Pro Val Gln Thr Pro Lys Gln Lys Arg Asp Arg         
        115                 120                 125                     

atc atg gtt cac ggc gga gag ttt gtc tcc ttg gtg gtc act ggc aat      432
Ile Met Val His Gly Gly Glu Phe Val Ser Leu Val Val Thr Gly Asn         
    130                 135                 140                         

aac ttc gac gaa gca tcg gct gca gcg cat gaa gat gca gag cgc acc      480
Asn Phe Asp Glu Ala Ser Ala Ala Ala His Glu Asp Ala Glu Arg Thr         
145                 150                 155                 160         

ggc gca acg ctg atc gag cct ttc gat gct cgc aac acc gtc atc ggt      528
Gly Ala Thr Leu Ile Glu Pro Phe Asp Ala Arg Asn Thr Val Ile Gly         
                165                 170                 175             

cag ggc acc gtg gct gct gag atc ttg tcg cag ctg act tcc atg ggc      576
Gln Gly Thr Val Ala Ala Glu Ile Leu Ser Gln Leu Thr Ser Met Gly         
            180                 185                 190                 

aag agt gca gat cac gtg atg gtt cca gtc ggc ggt ggc gga ctt ctt      624
Lys Ser Ala Asp His Val Met Val Pro Val Gly Gly Gly Gly Leu Leu         
        195                 200                 205                     

gca ggt gtg gtc agc tac atg gct gat atg gca cct cgc act gcg atc      672
Ala Gly Val Val Ser Tyr Met Ala Asp Met Ala Pro Arg Thr Ala Ile         
    210                 215                 220                         

gtt ggt atc gaa cca gcg gga gca gca tcc atg cag gct gca ttg cac      720
Val Gly Ile Glu Pro Ala Gly Ala Ala Ser Met Gln Ala Ala Leu His         
225                 230                 235                 240         

aat ggt gga cca atc act ttg gag act gtt gat ccc ttt gtg gac ggc      768
Asn Gly Gly Pro Ile Thr Leu Glu Thr Val Asp Pro Phe Val Asp Gly         
                245                 250                 255             

gca gca gtc aaa cgt gtc gga gat ctc aac tac acc atc gtg gag aag      816
Ala Ala Val Lys Arg Val Gly Asp Leu Asn Tyr Thr Ile Val Glu Lys         
            260                 265                 270                 

aac cag ggt cgc gtg cac atg atg agc gcg acc gag ggc gct gtg tgt      864
Asn Gln Gly Arg Val His Met Met Ser Ala Thr Glu Gly Ala Val Cys         
        275                 280                 285                     

act gag atg ctc gat ctt tac caa aac gaa ggc atc atc gcg gag cct      912
Thr Glu Met Leu Asp Leu Tyr Gln Asn Glu Gly Ile Ile Ala Glu Pro         
    290                 295                 300                         

gct ggc gcg ctg tct atc gct ggg ttg aag gaa atg tcc ttt gca cct      960
Ala Gly Ala Leu Ser Ile Ala Gly Leu Lys Glu Met Ser Phe Ala Pro         
305                 310                 315                 320         

ggt tct gtc gtg gtg tgc atc atc tct ggt ggc aac aac gat gtg ctg     1008
Gly Ser Val Val Val Cys Ile Ile Ser Gly Gly Asn Asn Asp Val Leu         
                325                 330                 335             

cgt tat gcg gaa atc gct gag cgc tcc ttg gtg cac cgc ggt ttg aag     1056
Arg Tyr Ala Glu Ile Ala Glu Arg Ser Leu Val His Arg Gly Leu Lys         
            340                 345                 350                 

cac tac ttc ttg gtg aac ttc ccg caa aag cct ggt cag ttg cgt cac     1104
His Tyr Phe Leu Val Asn Phe Pro Gln Lys Pro Gly Gln Leu Arg His         
        355                 360                 365                     

ttc ctg gaa gat atc ctg gga ccg gat gat gac atc acg ctg ttt gag     1152
Phe Leu Glu Asp Ile Leu Gly Pro Asp Asp Asp Ile Thr Leu Phe Glu         
    370                 375                 380                         

tac ctc aag cgc aac aac cgt gag acc ggt act gcg ttg gtg ggt att     1200
Tyr Leu Lys Arg Asn Asn Arg Glu Thr Gly Thr Ala Leu Val Gly Ile         
385                 390                 395                 400         

cac ttg agt gaa gca tca gga ttg gat tct ttg ctg gaa cgt atg gag     1248
His Leu Ser Glu Ala Ser Gly Leu Asp Ser Leu Leu Glu Arg Met Glu         
                405                 410                 415             

gaa tcg gca att gat tcc cgt cgc ctc gag ccg ggc acc cct gag tac     1296
Glu Ser Ala Ile Asp Ser Arg Arg Leu Glu Pro Gly Thr Pro Glu Tyr         
            420                 425                 430                 

gaa tac ttg acc taa                                                 1311
Glu Tyr Leu Thr                                                         
        435                                                             


<210>  18
<211>  436
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  18

Met Ser Glu Thr Tyr Val Ser Glu Lys Ser Pro Gly Val Met Ala Ser 
1               5                   10                  15      


Gly Ala Glu Leu Ile Arg Ala Ala Asp Ile Gln Thr Ala Gln Ala Arg 
            20                  25                  30          


Ile Ser Ser Val Ile Ala Pro Thr Pro Leu Gln Tyr Cys Pro Arg Leu 
        35                  40                  45              


Ser Glu Glu Thr Gly Ala Glu Ile Tyr Leu Lys Arg Glu Asp Leu Gln 
    50                  55                  60                  


Asp Val Arg Ser Tyr Lys Ile Arg Gly Ala Leu Asn Ser Gly Ala Gln 
65                  70                  75                  80  


Leu Thr Gln Glu Gln Arg Asp Ala Gly Ile Val Ala Ala Ser Ala Gly 
                85                  90                  95      


Asn His Ala Gln Gly Val Ala Tyr Val Cys Lys Ser Leu Gly Val Gln 
            100                 105                 110         


Gly Arg Ile Tyr Val Pro Val Gln Thr Pro Lys Gln Lys Arg Asp Arg 
        115                 120                 125             


Ile Met Val His Gly Gly Glu Phe Val Ser Leu Val Val Thr Gly Asn 
    130                 135                 140                 


Asn Phe Asp Glu Ala Ser Ala Ala Ala His Glu Asp Ala Glu Arg Thr 
145                 150                 155                 160 


Gly Ala Thr Leu Ile Glu Pro Phe Asp Ala Arg Asn Thr Val Ile Gly 
                165                 170                 175     


Gln Gly Thr Val Ala Ala Glu Ile Leu Ser Gln Leu Thr Ser Met Gly 
            180                 185                 190         


Lys Ser Ala Asp His Val Met Val Pro Val Gly Gly Gly Gly Leu Leu 
        195                 200                 205             


Ala Gly Val Val Ser Tyr Met Ala Asp Met Ala Pro Arg Thr Ala Ile 
    210                 215                 220                 


Val Gly Ile Glu Pro Ala Gly Ala Ala Ser Met Gln Ala Ala Leu His 
225                 230                 235                 240 


Asn Gly Gly Pro Ile Thr Leu Glu Thr Val Asp Pro Phe Val Asp Gly 
                245                 250                 255     


Ala Ala Val Lys Arg Val Gly Asp Leu Asn Tyr Thr Ile Val Glu Lys 
            260                 265                 270         


Asn Gln Gly Arg Val His Met Met Ser Ala Thr Glu Gly Ala Val Cys 
        275                 280                 285             


Thr Glu Met Leu Asp Leu Tyr Gln Asn Glu Gly Ile Ile Ala Glu Pro 
    290                 295                 300                 


Ala Gly Ala Leu Ser Ile Ala Gly Leu Lys Glu Met Ser Phe Ala Pro 
305                 310                 315                 320 


Gly Ser Val Val Val Cys Ile Ile Ser Gly Gly Asn Asn Asp Val Leu 
                325                 330                 335     


Arg Tyr Ala Glu Ile Ala Glu Arg Ser Leu Val His Arg Gly Leu Lys 
            340                 345                 350         


His Tyr Phe Leu Val Asn Phe Pro Gln Lys Pro Gly Gln Leu Arg His 
        355                 360                 365             


Phe Leu Glu Asp Ile Leu Gly Pro Asp Asp Asp Ile Thr Leu Phe Glu 
    370                 375                 380                 


Tyr Leu Lys Arg Asn Asn Arg Glu Thr Gly Thr Ala Leu Val Gly Ile 
385                 390                 395                 400 


His Leu Ser Glu Ala Ser Gly Leu Asp Ser Leu Leu Glu Arg Met Glu 
                405                 410                 415     


Glu Ser Ala Ile Asp Ser Arg Arg Leu Glu Pro Gly Thr Pro Glu Tyr 
            420                 425                 430         


Glu Tyr Leu Thr 
        435     


<210>  19
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer rel_XL_A1


<220>
<221>  misc_feature
<222>  (1)..(2)

<220>
<221>  misc_structure
<222>  (3)..(8)
<223>  EcoRI-Restriktionsschnittstelle

<400>  19
gcgaattcta tcggatggaa catgaccg                                        28


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer rel_XL_E1


<220>
<221>  misc_feature
<222>  (1)..(2)

<220>
<221>  misc_structure
<222>  (3)..(8)
<223>  EcoRI-Restriktionsschnittstelle

<400>  20
gcgaattcat gcggatgcca acaagatc                                        28


<210>  21
<211>  2283
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(2280)
<223>  rel-Wildtyp-Gen gem EP 1 108 790

<220>
<221>  misc_feature
<222>  (785)..(785)
<223>  Adenin

<400>  21
atg agt ctg gag cgc aac aca caa aaa tct tcc atg ggt gtg cga agc       48
Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser         
1               5                   10                  15              

atg tca gcc agg ctt gcc cgc agc ctc aca gga aac cgc gtt cgc acc       96
Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr         
            20                  25                  30                  

aac cct gtg ctg gat ccg ctg ctg agc atc cac cgg caa ttt cac cca      144
Asn Pro Val Leu Asp Pro Leu Leu Ser Ile His Arg Gln Phe His Pro         
        35                  40                  45                      

cgc gcc gac gta caa gtg ttg gaa cgt gca tat gac acc gcg gaa cgt      192
Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg         
    50                  55                  60                          

ctt cat gat ggt gtg att cga aaa tcg ggc gat ccg tat att acc cac      240
Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His         
65                  70                  75                  80          

ccg ttg gct gtc gcc acc atc gcc gcg gaa atc ggc atg gac acc acc      288
Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr         
                85                  90                  95              

acg ctc gtc gca gcc ttg ttg cat gac acg gtg gaa gac acc gac tac      336
Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr         
            100                 105                 110                 

tct ttg gac gat ctc acc cga gat ttc gga gaa gaa gtt gcc agg ctt      384
Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu         
        115                 120                 125                     

gtc gac ggt gtc acc aag ctc gac aaa gtc gca cta ggt gct gcc gcg      432
Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala         
    130                 135                 140                         

gag gcc gaa acg att cgc aaa atg atc gtc gcc atg agc cag gac ccc      480
Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro         
145                 150                 155                 160         

cgc gtg ctg gtg att aaa gtg gcc gac cgt ttg cac aat atg cgc acc      528
Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr         
                165                 170                 175             

atg cgg ttc ctg ccg ccg gaa aag caa gct aaa aaa gca cgc caa acc      576
Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr         
            180                 185                 190                 

ctt gaa gtg att gct cct ttg gca cac cgc ctg ggc atg gcc agc gtg      624
Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val         
        195                 200                 205                     

aaa tgg gaa ttg gaa gat cta tcc ttt gcc att ttg tac ccc aag aag      672
Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys         
    210                 215                 220                         

tac gaa gag atc gtg cgt ctt gtt gcc gac cgc gcg ccc tct aga gac      720
Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp         
225                 230                 235                 240         

cgg tac ctc aaa gaa att att gat caa gtc acc ggt ggc ttg cgc gaa      768
Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu         
                245                 250                 255             

aac aac atc gcg gca gaa gtg ctt ggt cga cca aag cac tac tgg tct      816
Asn Asn Ile Ala Ala Glu Val Leu Gly Arg Pro Lys His Tyr Trp Ser         
            260                 265                 270                 

atc tat caa aag atg atc gtt cgc ggt cgt gat ttt gac gat att ttt      864
Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe         
        275                 280                 285                     

gat ctt gtt ggc atc cgc atc ctg gta gac aac gtg aac aac tgt tac      912
Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr         
    290                 295                 300                         

gcc gcc atc ggt gtc gtg cac tcc ctg ttc aat gct ctg cct ggc cga      960
Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg         
305                 310                 315                 320         

ttc aaa gac tat att tca gcc ccg cgc ttc ggt gtc tac caa tcc ctg     1008
Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu         
                325                 330                 335             

cac acc acc gtg atg gga cct ggc ggt aag cct ctg gaa gtt cag gca     1056
His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala         
            340                 345                 350                 

cgt acc cac gac atg cac tac aac gcc gaa ttc ggc att gca gcg cac     1104
Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His         
        355                 360                 365                     

tgg cga tac aaa gaa acc aaa ggc agc cac agt ggc gag caa gcc gaa     1152
Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu         
    370                 375                 380                         

gtg gat caa atg gcg tgg atg cgc caa ctt ctg gac tgg caa aaa gaa     1200
Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu         
385                 390                 395                 400         

gca gcc gac ccc aac gag ttc ctg gac agc ctg cgc tac gat ctg act     1248
Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr         
                405                 410                 415             

tcc aag cag atc ttc gtg ttc aca ccc aaa ggt gat gtg gtc aac ctg     1296
Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu         
            420                 425                 430                 

ccg gtg aac tcc acc ccg gtg gac ttc gcc tac gcg gtg cac acc gaa     1344
Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu         
        435                 440                 445                     

gtg ggg cac cgc tgc atc ggc gcc aaa atc aac ggc aaa ctg gtc gct     1392
Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala         
    450                 455                 460                         

ttg gaa acg aaa ctc aaa tcc ggc gat cgt gtt gaa gtc ttt acc tcc     1440
Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser         
465                 470                 475                 480         

aag gac caa aac gct ggc cca agt agg gga tgg caa gaa ttt gtt gtc     1488
Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val         
                485                 490                 495             

tca cct cgt gca aag gcc aag att cgc cag tgg ttt gcc aag gaa cga     1536
Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg         
            500                 505                 510                 

cgc gaa gaa tac cta gaa gcc gga cgc gat gcg ctg gca gca gtt att     1584
Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile         
        515                 520                 525                     

cag cgt ggc ggc ctg cca atg cac cgc ttg ttc acc gcg tcc tcc atg     1632
Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met         
    530                 535                 540                         

aag acg gtg gca aca gag ctg cac tac cca gat gta gat gcg ctc tac     1680
Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr         
545                 550                 555                 560         

aca gcc atc ggc tcc ggt tct gta tct gcg caa cac gta gtc aac cgt     1728
Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg         
                565                 570                 575             

ctc atg gct atc ttt ggt gac gaa gaa gat gcc gaa gac gca ttg gtt     1776
Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val         
            580                 585                 590                 

gca cgc acc cca ttc agc gag ctg gtc aac tcc cgt gcc acc acg gaa     1824
Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu         
        595                 600                 605                     

agc agc acc ggc atc ctg gtc gaa ggc agc cca gat gtc atg gct aag     1872
Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys         
    610                 615                 620                         

ctc gct aaa tgc tgt atg cca gtg cca gga gat gaa atc ttt gga ttc     1920
Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe         
625                 630                 635                 640         

gtc acc cgt ggt ggc ggt gtc tcc gta cac cga aca gac tgc acg aat     1968
Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn         
                645                 650                 655             

gtg gaa aag ctc aaa gaa gag cca gaa cgc att gtc tcc gtc tcc tgg     2016
Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp         
            660                 665                 670                 

gct tcg gaa ggt caa ggt tca gta ttc tct gcc aca ctg cag ctt gaa     2064
Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu         
        675                 680                 685                     

gca ctt gat cgc gca ggc ctg ctc ttt gag ctc acc cgc gta atc aac     2112
Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn         
    690                 695                 700                         

gaa caa aag gtc tcc gtt acc gca atg aac tcc cat tgc tca gaa gac     2160
Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp         
705                 710                 715                 720         

cgc gta gcc acc gtg cgc ttc acc ttt gcg gtc tct gac acc aag cag     2208
Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln         
                725                 730                 735             

ttg gga tcc ctg atg aca cag ctg cgc aat gcc gaa gga gtg ttt gat     2256
Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp         
            740                 745                 750                 

gtc tac cga gtg acc tcg ggt ggc tag                                 2283
Val Tyr Arg Val Thr Ser Gly Gly                                         
        755                 760                                         


<210>  22
<211>  760
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  22

Met Ser Leu Glu Arg Asn Thr Gln Lys Ser Ser Met Gly Val Arg Ser 
1               5                   10                  15      


Met Ser Ala Arg Leu Ala Arg Ser Leu Thr Gly Asn Arg Val Arg Thr 
            20                  25                  30          


Asn Pro Val Leu Asp Pro Leu Leu Ser Ile His Arg Gln Phe His Pro 
        35                  40                  45              


Arg Ala Asp Val Gln Val Leu Glu Arg Ala Tyr Asp Thr Ala Glu Arg 
    50                  55                  60                  


Leu His Asp Gly Val Ile Arg Lys Ser Gly Asp Pro Tyr Ile Thr His 
65                  70                  75                  80  


Pro Leu Ala Val Ala Thr Ile Ala Ala Glu Ile Gly Met Asp Thr Thr 
                85                  90                  95      


Thr Leu Val Ala Ala Leu Leu His Asp Thr Val Glu Asp Thr Asp Tyr 
            100                 105                 110         


Ser Leu Asp Asp Leu Thr Arg Asp Phe Gly Glu Glu Val Ala Arg Leu 
        115                 120                 125             


Val Asp Gly Val Thr Lys Leu Asp Lys Val Ala Leu Gly Ala Ala Ala 
    130                 135                 140                 


Glu Ala Glu Thr Ile Arg Lys Met Ile Val Ala Met Ser Gln Asp Pro 
145                 150                 155                 160 


Arg Val Leu Val Ile Lys Val Ala Asp Arg Leu His Asn Met Arg Thr 
                165                 170                 175     


Met Arg Phe Leu Pro Pro Glu Lys Gln Ala Lys Lys Ala Arg Gln Thr 
            180                 185                 190         


Leu Glu Val Ile Ala Pro Leu Ala His Arg Leu Gly Met Ala Ser Val 
        195                 200                 205             


Lys Trp Glu Leu Glu Asp Leu Ser Phe Ala Ile Leu Tyr Pro Lys Lys 
    210                 215                 220                 


Tyr Glu Glu Ile Val Arg Leu Val Ala Asp Arg Ala Pro Ser Arg Asp 
225                 230                 235                 240 


Arg Tyr Leu Lys Glu Ile Ile Asp Gln Val Thr Gly Gly Leu Arg Glu 
                245                 250                 255     


Asn Asn Ile Ala Ala Glu Val Leu Gly Arg Pro Lys His Tyr Trp Ser 
            260                 265                 270         


Ile Tyr Gln Lys Met Ile Val Arg Gly Arg Asp Phe Asp Asp Ile Phe 
        275                 280                 285             


Asp Leu Val Gly Ile Arg Ile Leu Val Asp Asn Val Asn Asn Cys Tyr 
    290                 295                 300                 


Ala Ala Ile Gly Val Val His Ser Leu Phe Asn Ala Leu Pro Gly Arg 
305                 310                 315                 320 


Phe Lys Asp Tyr Ile Ser Ala Pro Arg Phe Gly Val Tyr Gln Ser Leu 
                325                 330                 335     


His Thr Thr Val Met Gly Pro Gly Gly Lys Pro Leu Glu Val Gln Ala 
            340                 345                 350         


Arg Thr His Asp Met His Tyr Asn Ala Glu Phe Gly Ile Ala Ala His 
        355                 360                 365             


Trp Arg Tyr Lys Glu Thr Lys Gly Ser His Ser Gly Glu Gln Ala Glu 
    370                 375                 380                 


Val Asp Gln Met Ala Trp Met Arg Gln Leu Leu Asp Trp Gln Lys Glu 
385                 390                 395                 400 


Ala Ala Asp Pro Asn Glu Phe Leu Asp Ser Leu Arg Tyr Asp Leu Thr 
                405                 410                 415     


Ser Lys Gln Ile Phe Val Phe Thr Pro Lys Gly Asp Val Val Asn Leu 
            420                 425                 430         


Pro Val Asn Ser Thr Pro Val Asp Phe Ala Tyr Ala Val His Thr Glu 
        435                 440                 445             


Val Gly His Arg Cys Ile Gly Ala Lys Ile Asn Gly Lys Leu Val Ala 
    450                 455                 460                 


Leu Glu Thr Lys Leu Lys Ser Gly Asp Arg Val Glu Val Phe Thr Ser 
465                 470                 475                 480 


Lys Asp Gln Asn Ala Gly Pro Ser Arg Gly Trp Gln Glu Phe Val Val 
                485                 490                 495     


Ser Pro Arg Ala Lys Ala Lys Ile Arg Gln Trp Phe Ala Lys Glu Arg 
            500                 505                 510         


Arg Glu Glu Tyr Leu Glu Ala Gly Arg Asp Ala Leu Ala Ala Val Ile 
        515                 520                 525             


Gln Arg Gly Gly Leu Pro Met His Arg Leu Phe Thr Ala Ser Ser Met 
    530                 535                 540                 


Lys Thr Val Ala Thr Glu Leu His Tyr Pro Asp Val Asp Ala Leu Tyr 
545                 550                 555                 560 


Thr Ala Ile Gly Ser Gly Ser Val Ser Ala Gln His Val Val Asn Arg 
                565                 570                 575     


Leu Met Ala Ile Phe Gly Asp Glu Glu Asp Ala Glu Asp Ala Leu Val 
            580                 585                 590         


Ala Arg Thr Pro Phe Ser Glu Leu Val Asn Ser Arg Ala Thr Thr Glu 
        595                 600                 605             


Ser Ser Thr Gly Ile Leu Val Glu Gly Ser Pro Asp Val Met Ala Lys 
    610                 615                 620                 


Leu Ala Lys Cys Cys Met Pro Val Pro Gly Asp Glu Ile Phe Gly Phe 
625                 630                 635                 640 


Val Thr Arg Gly Gly Gly Val Ser Val His Arg Thr Asp Cys Thr Asn 
                645                 650                 655     


Val Glu Lys Leu Lys Glu Glu Pro Glu Arg Ile Val Ser Val Ser Trp 
            660                 665                 670         


Ala Ser Glu Gly Gln Gly Ser Val Phe Ser Ala Thr Leu Gln Leu Glu 
        675                 680                 685             


Ala Leu Asp Arg Ala Gly Leu Leu Phe Glu Leu Thr Arg Val Ile Asn 
    690                 695                 700                 


Glu Gln Lys Val Ser Val Thr Ala Met Asn Ser His Cys Ser Glu Asp 
705                 710                 715                 720 


Arg Val Ala Thr Val Arg Phe Thr Phe Ala Val Ser Asp Thr Lys Gln 
                725                 730                 735     


Leu Gly Ser Leu Met Thr Gln Leu Arg Asn Ala Glu Gly Val Phe Asp 
            740                 745                 750         


Val Tyr Arg Val Thr Ser Gly Gly 
        755                 760 




