                         SEQUENCE LISTING

<110>  TOVEY, Michael
       LALLEMAND, Christophe
 
<120>  GENE REPORTER ASSAY, KIT AND CELLS WITH IMPROVED SENSITIVITY 
       AND/OR SPECIFICITY FOR DETERMINING THE LEVEL OF AN EXTRACELLULAR 
       SIGNAL

<130>  TOVEY8A PCT

<150>  US 60/863,479
<151>  2006-10-30

<160>  5     

<170>  PatentIn version 3.4

<210>  1
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  1
tctacaacag cctgatttcc ccgaaatgac ggcacgcagc cg                        42


<210>  2
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  2
tggggacttt ccgctgggga ctttccgctg gggactttcc gctggggact ttccgctggg     60

gactttccgc                                                            70


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  3
nnnsanttcc gggaantgns n                                               21


<210>  4
<211>  5834
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  4
cccgggaggt accgagctct tacgcgtgct agctcgagtc tacaacagcc tgatttcccc     60

gaaatgacgg cacgcagccg agatctgcat ctcaattagt cagcaaccat agtcccgccc    120

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc    180

tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag    240

aagtagtgag gaggcttttt tggaggccta ggcttttgca aaaagcttgg cattccggta    300

ctgttggtaa aatggaagac gccaaaaaca taaagaaagg cccggcgcca ttctatcctc    360

tagaggatgg aaccgctgga gagcaactgc ataaggctat gaagagatac gccctggttc    420

ctggaacaat tgcttttaca gatgcacata tcgaggtgaa catcacgtac gcggaatact    480

tcgaaatgtc cgttcggttg gcagaagcta tgaaacgata tgggctgaat acaaatcaca    540

gaatcgtcgt atgcagtgaa aactctcttc aattctttat gccggtgttg ggcgcgttat    600

ttatcggagt tgcagttgcg cccgcgaacg acatttataa tgaacgtgaa ttgctcaaca    660

gtatgaacat ttcgcagcct accgtagtgt ttgtttccaa aaaggggttg caaaaaattt    720

tgaacgtgca aaaaaaatta ccaataatcc agaaaattat tatcatggat tctaaaacgg    780

attaccaggg atttcagtcg atgtacacgt tcgtcacatc tcatctacct cccggtttta    840

atgaatacga ttttgtacca gagtcctttg atcgtgacaa aacaattgca ctgataatga    900

attcctctgg atctactggg ttacctaagg gtgtggccct tccgcataga actgcctgcg    960

tcagattctc gcatgccaga gatcctattt ttggcaatca aatcattccg gatactgcga   1020

ttttaagtgt tgttccattc catcacggtt ttggaatgtt tactacactc ggatatttga   1080

tatgtggatt tcgagtcgtc ttaatgtata gatttgaaga agagctgttt ttacgatccc   1140

ttcaggatta caaaattcaa agtgcgttgc tagtaccaac cctattttca ttcttcgcca   1200

aaagcactct gattgacaaa tacgatttat ctaatttaca cgaaattgct tctgggggcg   1260

cacctctttc gaaagaagtc ggggaagcgg ttgcaaaacg cttccatctt ccagggatac   1320

gacaaggata tgggctcact gagactacat cagctattct gattacaccc gagggggatg   1380

ataaaccggg cgcggtcggt aaagttgttc cattttttga agcgaaggtt gtggatctgg   1440

ataccgggaa aacgctgggc gttaatcaga gaggcgaatt atgtgtcaga ggacctatga   1500

ttatgtccgg ttatgtaaac aatccggaag cgaccaacgc cttgattgac aaggatggat   1560

ggctacattc tggagacata gcttactggg acgaagacga acacttcttc atagttgacc   1620

gcttgaagtc tttaattaaa tacaaaggat atcaggtggc ccccgctgaa ttggaatcga   1680

tattgttaca acaccccaac atcttcgacg cgggcgtggc aggtcttccc gacgatgacg   1740

ccggtgaact tcccgccgcc gttgttgttt tggagcacgg aaagacgatg acggaaaaag   1800

agatcgtgga ttacgtcgcc agtcaagtaa caaccgcgaa aaagttgcgc ggaggagttg   1860

tgtttgtgga cgaagtaccg aaaggtctta ccggaaaact cgacgcaaga aaaatcagag   1920

agatcctcat aaaggccaag aagggcggaa agtccaaatt gtaaaatgta actgtattca   1980

gcgatgacga aattcttagc tattgtaata ctgcgatgag tggcagggcg gggcgtaatt   2040

tttttaaggc agttattggt gcccttaaac gcctggttgc tacgcctgaa taagtgataa   2100

taagcggatg aatggcagaa attcgccgga tctttgtgaa ggaaccttac ttctgtggtg   2160

tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat ataaaatttt   2220

taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag attccaacct   2280

atggaactga tgaatgggag cagtggtgga atgcctttaa tgaggaaaac ctgttttgct   2340

cagaagaaat gccatctagt gatgatgagg ctactgctga ctctcaacat tctactcctc   2400

caaaaaagaa gagaaaggta gaagacccca aggactttcc ttcagaattg ctaagttttt   2460

tgagtcatgc tgtgtttagt aatagaactc ttgcttgctt tgctatttac accacaaagg   2520

aaaaagctgc actgctatac aagaaaatta tggaaaaata ttctgtaacc tttataagta   2580

ggcataacag ttataatcat aacatactgt tttttcttac tccacacagg catagagtgt   2640

ctgctattaa taactatgct caaaaattgt gtacctttag ctttttaatt tgtaaagggg   2700

ttaataagga atatttgatg tatagtgcct tgactagaga tcataatcag ccataccaca   2760

tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat   2820

aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa   2880

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt   2940

ttgtccaaac tcatcaatgt atcttatgat gtctggatcc gtcgaccgat gcccttgaga   3000

gccttcaacc cagtcagctc cttccggtgg gcgcggggca tgactatcgt cgccgcactt   3060

atgactgtct tctttatcat gcaactcgta ggacaggtgc cggcagcgct cttccgcttc   3120

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc   3180

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc   3240

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag   3300

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc   3360

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt   3420

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct   3480

ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg   3540

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct   3600

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat   3660

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg   3720

ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa   3780

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt   3840

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc   3900

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt   3960

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta   4020

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat   4080

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac   4140

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg   4200

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag   4260

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt   4320

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt   4380

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt   4440

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt   4500

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct   4560

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt   4620

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac   4680

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa   4740

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa   4800

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca   4860

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct   4920

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga   4980

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc   5040

tgacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac   5100

cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc   5160

cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt   5220

tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg   5280

gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag   5340

tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt   5400

ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt   5460

taacgcgaat tttaacaaaa tattaacgct tacaatttgc cattcgccat tcaggctgcg   5520

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc ccaagctacc   5580

atgataagta agtaatatta aggtacgtgg aggttttact tgctttaaaa aacctcccac   5640

acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg   5700

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt   5760

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat ggtactgtaa   5820

ctgagctaac ataa                                                     5834


<210>  5
<211>  5864
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  5
cccgggaggt accgagctct tacgcgtgct agctcgagtc tggggacttt ccgctgggga     60

ctttccgctg gggactttcc gctggggact ttccgctggg gactttccgc agatctgcat    120

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg    180

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc    240

gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta    300

ggcttttgca aaaagcttgg cattccggta ctgttggtaa aatggaagac gccaaaaaca    360

taaagaaagg cccggcgcca ttctatcctc tagaggatgg aaccgctgga gagcaactgc    420

ataaggctat gaagagatac gccctggttc ctggaacaat tgcttttaca gatgcacata    480

tcgaggtgaa catcacgtac gcggaatact tcgaaatgtc cgttcggttg gcagaagcta    540

tgaaacgata tgggctgaat acaaatcaca gaatcgtcgt atgcagtgaa aactctcttc    600

aattctttat gccggtgttg ggcgcgttat ttatcggagt tgcagttgcg cccgcgaacg    660

acatttataa tgaacgtgaa ttgctcaaca gtatgaacat ttcgcagcct accgtagtgt    720

ttgtttccaa aaaggggttg caaaaaattt tgaacgtgca aaaaaaatta ccaataatcc    780

agaaaattat tatcatggat tctaaaacgg attaccaggg atttcagtcg atgtacacgt    840

tcgtcacatc tcatctacct cccggtttta atgaatacga ttttgtacca gagtcctttg    900

atcgtgacaa aacaattgca ctgataatga attcctctgg atctactggg ttacctaagg    960

gtgtggccct tccgcataga actgcctgcg tcagattctc gcatgccaga gatcctattt   1020

ttggcaatca aatcattccg gatactgcga ttttaagtgt tgttccattc catcacggtt   1080

ttggaatgtt tactacactc ggatatttga tatgtggatt tcgagtcgtc ttaatgtata   1140

gatttgaaga agagctgttt ttacgatccc ttcaggatta caaaattcaa agtgcgttgc   1200

tagtaccaac cctattttca ttcttcgcca aaagcactct gattgacaaa tacgatttat   1260

ctaatttaca cgaaattgct tctgggggcg cacctctttc gaaagaagtc ggggaagcgg   1320

ttgcaaaacg cttccatctt ccagggatac gacaaggata tgggctcact gagactacat   1380

cagctattct gattacaccc gagggggatg ataaaccggg cgcggtcggt aaagttgttc   1440

cattttttga agcgaaggtt gtggatctgg ataccgggaa aacgctgggc gttaatcaga   1500

gaggcgaatt atgtgtcaga ggacctatga ttatgtccgg ttatgtaaac aatccggaag   1560

cgaccaacgc cttgattgac aaggatggat ggctacattc tggagacata gcttactggg   1620

acgaagacga acacttcttc atagttgacc gcttgaagtc tttaattaaa tacaaaggat   1680

atcaggtggc ccccgctgaa ttggaatcga tattgttaca acaccccaac atcttcgacg   1740

cgggcgtggc aggtcttccc gacgatgacg ccggtgaact tcccgccgcc gttgttgttt   1800

tggagcacgg aaagacgatg acggaaaaag agatcgtgga ttacgtcgcc agtcaagtaa   1860

caaccgcgaa aaagttgcgc ggaggagttg tgtttgtgga cgaagtaccg aaaggtctta   1920

ccggaaaact cgacgcaaga aaaatcagag agatcctcat aaaggccaag aagggcggaa   1980

agtccaaatt gtaaaatgta actgtattca gcgatgacga aattcttagc tattgtaata   2040

ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc agttattggt gcccttaaac   2100

gcctggttgc tacgcctgaa taagtgataa taagcggatg aatggcagaa attcgccgga   2160

tctttgtgaa ggaaccttac ttctgtggtg tgacataatt ggacaaacta cctacagaga   2220

tttaaagctc taaggtaaat ataaaatttt taagtgtata atgtgttaaa ctactgattc   2280

taattgtttg tgtattttag attccaacct atggaactga tgaatgggag cagtggtgga   2340

atgcctttaa tgaggaaaac ctgttttgct cagaagaaat gccatctagt gatgatgagg   2400

ctactgctga ctctcaacat tctactcctc caaaaaagaa gagaaaggta gaagacccca   2460

aggactttcc ttcagaattg ctaagttttt tgagtcatgc tgtgtttagt aatagaactc   2520

ttgcttgctt tgctatttac accacaaagg aaaaagctgc actgctatac aagaaaatta   2580

tggaaaaata ttctgtaacc tttataagta ggcataacag ttataatcat aacatactgt   2640

tttttcttac tccacacagg catagagtgt ctgctattaa taactatgct caaaaattgt   2700

gtacctttag ctttttaatt tgtaaagggg ttaataagga atatttgatg tatagtgcct   2760

tgactagaga tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac   2820

ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg   2880

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa   2940

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatgat   3000

gtctggatcc gtcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg   3060

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta   3120

ggacaggtgc cggcagcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt   3180

tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc   3240

aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa   3300

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa   3360

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc   3420

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc   3480

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag   3540

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga   3600

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc   3660

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac   3720

agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg   3780

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca   3840

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa   3900

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa   3960

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt   4020

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag   4080

ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat   4140

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc   4200

cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa   4260

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca   4320

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa   4380

cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt   4440

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc   4500

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact   4560

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc   4620

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg   4680

ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct   4740

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc   4800

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag   4860

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac   4920

acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg   4980

ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt   5040

tccgcgcaca tttccccgaa aagtgccacc tgacgcgccc tgtagcggcg cattaagcgc   5100

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc   5160

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct   5220

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa   5280

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc   5340

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact   5400

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg   5460

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct   5520

tacaatttgc cattcgccat tcaggctgcg caactgttgg gaagggcgat cggtgcgggc   5580

ctcttcgcta ttacgccagc ccaagctacc atgataagta agtaatatta aggtacgtgg   5640

aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga   5700

atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata   5760

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca   5820

aactcatcaa tgtatcttat ggtactgtaa ctgagctaac ataa                    5864


