                                SEQUENCE LISTING

<110> Presnell, Scott
      Taft, David
      Foley, Kevin
      

<120> VARIANTS AND METHODS OF USING TRANSFORMING GROWTH
  FACTOR BETA-9

<130> 06-45PC

<150> 60/864,873          
<151> 2006-11-08  

<160> 26

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1819
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (71)...(676)

<400> 1
cgggcgcggg gcgcaggcgg gctcctccgg cgcgtgcgga cgctgagcgt ggcctgtccc     60
tcaggtctgg atg ctg gta gcc ggc ttc ctg ctg gcg ctg ccg ccg agc       109
            Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser
             1               5                   10
 
tgg gcc gcg ggc gcc ccg agg gcg ggc agg cgc ccc gcg cgg ccg cgg      157
Trp Ala Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg
     15                  20                  25
 
ggc tgc gcg gac cgg ccg gag gag cta ctg gag cag ctg tac ggg cgc      205
Gly Cys Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg
 30                  35                  40                  45
 
ctg gcg gcc ggc gtg ctc agt gcc ttc cac cac acg ctg cag ctg ggg      253
Leu Ala Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly
                 50                  55                  60
 
ccg cgt gag cag gcg cgc aac gcg agc tgc ccg gca ggg ggc agg ccc      301
Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro
             65                  70                  75
 
gcc gac cgc cgc ttc cgg ccg ccc acc aac ctg cgc agc gtg tcg ccc      349
Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro
         80                  85                  90
 
tgg gcc tac aga atc tcc tac gac ccg gcg agg tac ccc agg tac ctg      397
Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu
     95                 100                 105
 
cct gaa gcc tac tgc ctg tgc cgg ggc tgc ctg acc ggg ctg ttc ggc      445
Pro Glu Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly
110                 115                 120                 125
 
gag gag gac gtg cgc ttc cgc agc gcc cct gtc tac atg ccc acc gtc      493
Glu Glu Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val
                130                 135                 140
 
gtc ctg cgc cgc acc ccc gcc tgc gcc ggc ggc cgt tcc gtc tac acc      541
Val Leu Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr
            145                 150                 155
 
gag gcc tac gtc acc atc ccc gtg ggc tgc acc tgc gtc ccc gag ccg      589
Glu Ala Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro
        160                 165                 170
 
gag aag gac gca gac agc atc aac tcc agc atc gac aaa cag ggc gcc      637
Glu Lys Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala
    175                 180                 185
 
aag ctc ctg ctg ggc ccc aac gac gcg ccc gct ggc ccc tgaggccggt       686
Lys Leu Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro
190                 195                 200
 
cctgccccgg gaggtctccc cggcccgcat cccgaggcgc ccaagctgga gccgcctgga    746
gggctcggtc ggcgacctct gaagagagtg caccgagcaa accaagtgcc ggagcaccag    806
cgccgccttt ccatggagac tcgtaagcag cttcatctga cacgggaatc cctggcttgc    866
ttttagctac aagcaagcag cgtggctgga agctgatggg aaacgacccg gcacgggcat    926
cctgtgtgcg gcccgcatgg agggtttgga aaagttcacg gaggctccct gaggagcctc    986
tcagatcggc tgctgcgggt gcagggcgtg actcaccgct gggtgcttgc caaagagata   1046
gggacgcata tgctttttaa agcaatctaa aaataataat aagtatagcg actatatacc   1106
tacttttaaa atcaactgtt ttgaatagag gcagagctat tttatattat caaatgagag   1166
ctactctgtt acatttctta acatataaac atcgtttttt acttcttctg gtagaatttt   1226
ttaaagcata attggaatcc ttggataaat tttgtagctg gtacactctg gcctgggtct   1286
ctgaattcag cctgtcaccg atggctgact gatgaaatgg acacgtctca tctgacccac   1346
tcttccttcc actgaaggtc ttcacgggcc tccaggtgga ccaaagggat gcacaggcgg   1406
ctcgcatgcc ccagggccag ctaagagttc caaagatctc agatttggtt ttagtcatga   1466
atacataaac agtctcaaac tcgcacaatt ttttccccct tttgaaagcc actggggcca   1526
atttgtggtt aagaggtggt gagataagaa gtggaacgtg acatctttgc cagttgtcag   1586
aagaatccaa gcaggtattg gcttagttgt aagggcttta ggatcaggcc gaatatgagg   1646
acaaagtggg ccacgttagc atctgcagag atcaatctgg aggcttctgt ttctgcattc   1706
tgccacgaga gctaggtcct tgatcttttc tttagattga aagtctgtct ctgaacacaa   1766
ttatttgtaa aagttagaag ttctttttta aatcattaaa agaggcttgc tga          1819

<210> 2
<211> 202
<212> PRT
<213> Homo sapiens

<400> 2
Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala
 1               5                  10                  15      
Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala
            20                  25                  30          
Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala
        35                  40                  45              
Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu
    50                  55                  60                  
Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg
65                  70                  75                  80  
Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr
                85                  90                  95      
Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala
            100                 105                 110         
Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp
        115                 120                 125             
Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg
    130                 135                 140                 
Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr
145                 150                 155                 160 
Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp
                165                 170                 175     
Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu
            180                 185                 190         
Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro
        195                 200         


<210> 3
<211> 187
<212> PRT
<213> Homo sapiens

<400> 3
Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys
 1               5                  10                  15      
Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala
            20                  25                  30          
Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg
        35                  40                  45              
Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp
    50                  55                  60                  
Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala
65                  70                  75                  80  
Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu
                85                  90                  95      
Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu
            100                 105                 110         
Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu
        115                 120                 125             
Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala
    130                 135                 140                 
Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys
145                 150                 155                 160 
Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu
                165                 170                 175     
Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro
            180                 185         


<210> 4
<211> 186
<212> PRT
<213> Homo sapiens

<400> 4
Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala
 1               5                  10                  15      
Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala
            20                  25                  30          
Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu
        35                  40                  45              
Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg
    50                  55                  60                  
Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr
65                  70                  75                  80  
Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala
                85                  90                  95      
Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp
            100                 105                 110         
Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg
        115                 120                 125             
Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr
    130                 135                 140                 
Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp
145                 150                 155                 160 
Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu
                165                 170                 175     
Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro
            180                 185     


<210> 5
<211> 185
<212> PRT
<213> Homo sapiens

<400> 5
Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala Asp
 1               5                  10                  15      
Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala Gly
            20                  25                  30          
Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu Gln
        35                  40                  45              
Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg Arg
    50                  55                  60                  
Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr Arg
65                  70                  75                  80  
Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala Tyr
                85                  90                  95      
Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp Val
            100                 105                 110         
Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg Arg
        115                 120                 125             
Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr Val
    130                 135                 140                 
Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp Ala
145                 150                 155                 160 
Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu Leu
                165                 170                 175     
Gly Pro Asn Asp Ala Pro Ala Gly Pro
            180                 185 


<210> 6
<211> 23
<212> DNA
<213> Homo sapiens

<400> 6
ccgggtcgta ggagattctg tag                                              23

<210> 7
<211> 22
<212> DNA
<213> Homo sapiens

<400> 7
gcgtgctcag tgccttccac ca                                               22

<210> 8
<211> 1221
<212> DNA
<213> Mus musculis

<220> 
<221> CDS            
<222> (79)...(693)

<400> 8
gggtgtcgcc cttatttact tcgcagaaga gccttcagcc cccctcctaa caagtctgga     60
aagcatcacg gcgacgcg atg ttg ggg aca ctg gtc tgg atg ctc gcg gtc      111
                    Met Leu Gly Thr Leu Val Trp Met Leu Ala Val
                     1               5                   10
 
ggc ttc ctg ctg gca ctg gcg ccg ggc cgc gcg gcg ggc gcg ctg agg      159
Gly Phe Leu Leu Ala Leu Ala Pro Gly Arg Ala Ala Gly Ala Leu Arg
             15                  20                  25
 
acc ggg agg cgc ccg gcg cgg ccg cgg gac tgc gcg gac cgg ccg gag      207
Thr Gly Arg Arg Pro Ala Arg Pro Arg Asp Cys Ala Asp Arg Pro Glu
         30                  35                  40
 
gag ctc ctg gag cag ctg tac ggg cgg ctg gcg gcc ggc gtg ctc agc      255
Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala Gly Val Leu Ser
     45                  50                  55
 
gcc ttc cac cac acg ctg cag ctc ggg ccg cgc gag cag gcg cgc aat      303
Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn
 60                  65                  70                  75
 
gcc agc tgc ccg gcc ggg ggc agg gcc gcc gac cgc cgc ttc cgg cca      351
Ala Ser Cys Pro Ala Gly Gly Arg Ala Ala Asp Arg Arg Phe Arg Pro
                 80                  85                  90
 
ccc acc aac ctg cgc agc gtg tcg ccc tgg gcg tac agg att tcc tac      399
Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr Arg Ile Ser Tyr
             95                 100                 105
 
gac cct gct cgc ttt ccg agg tac ctg ccc gaa gcc tac tgc ctg tgc      447
Asp Pro Ala Arg Phe Pro Arg Tyr Leu Pro Glu Ala Tyr Cys Leu Cys
        110                 115                 120
 
cga ggc tgc ctg acc ggg ctc tac ggg gag gag gac ttc cgc ttt cgc      495
Arg Gly Cys Leu Thr Gly Leu Tyr Gly Glu Glu Asp Phe Arg Phe Arg
    125                 130                 135
 
agc aca ccc gtc ttc tct cca gcc gtg gtg ctg cgg cgc aca gcg gcc      543
Ser Thr Pro Val Phe Ser Pro Ala Val Val Leu Arg Arg Thr Ala Ala
140                 145                 150                 155
 
tgc gcg ggc ggc cgc tct gtg tac gcc gaa cac tac atc acc atc ccg      591
Cys Ala Gly Gly Arg Ser Val Tyr Ala Glu His Tyr Ile Thr Ile Pro
                160                 165                 170
 
gtg ggc tgc acc tgc gtg ccc gag ccg gac aag tcc gcg gac agt gcg      639
Val Gly Cys Thr Cys Val Pro Glu Pro Asp Lys Ser Ala Asp Ser Ala
            175                 180                 185
 
aac tcc agc atg gac aag ctg ctg ctg ggg ccc gcc gac agg cct gcg      687
Asn Ser Ser Met Asp Lys Leu Leu Leu Gly Pro Ala Asp Arg Pro Ala
        190                 195                 200
 
ggg cgc tgatgccggg gactgcccgc catggcccag cttcctgcat gcatcaggtc       743
Gly Arg
    205
 
ccctggccct gacaaaaccc accccatgat ccctggccgc tgcctaattt ttccaaaagg    803
acagctacat aagctttaaa tatatttttc aaagtagaca ctacatatct acaactattt    863
tgaatagtgg cagaaactat tttcatatta gtaatttaga gcaagcatgt tgtttttaaa    923
cttctttgat atacaagcac atcacacaca tcccgttttc ctctagtagg attcttgagt    983
gcataattgt agtgctcaga tgaacttcct tctgctgcac tgtgccctgt ccctgagtct   1043
ctcctgtggc ccaagcttac taaggtgata atgagtgctc cggatctggg cacctaaggt   1103
ctccaggtcc ctggagaggg agggatgtgg gggggctaga accaagcgcc cctttgttct   1163
ttagcttatg gatggtctta actttataaa gattaaagtt tttggtgtta ttctttca     1221

<210> 9
<211> 205
<212> PRT
<213> Mus musculis

<400> 9
Met Leu Gly Thr Leu Val Trp Met Leu Ala Val Gly Phe Leu Leu Ala
 1               5                  10                  15      
Leu Ala Pro Gly Arg Ala Ala Gly Ala Leu Arg Thr Gly Arg Arg Pro
            20                  25                  30          
Ala Arg Pro Arg Asp Cys Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln
        35                  40                  45              
Leu Tyr Gly Arg Leu Ala Ala Gly Val Leu Ser Ala Phe His His Thr
    50                  55                  60                  
Leu Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala
65                  70                  75                  80  
Gly Gly Arg Ala Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg
                85                  90                  95      
Ser Val Ser Pro Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Phe
            100                 105                 110         
Pro Arg Tyr Leu Pro Glu Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr
        115                 120                 125             
Gly Leu Tyr Gly Glu Glu Asp Phe Arg Phe Arg Ser Thr Pro Val Phe
    130                 135                 140                 
Ser Pro Ala Val Val Leu Arg Arg Thr Ala Ala Cys Ala Gly Gly Arg
145                 150                 155                 160 
Ser Val Tyr Ala Glu His Tyr Ile Thr Ile Pro Val Gly Cys Thr Cys
                165                 170                 175     
Val Pro Glu Pro Asp Lys Ser Ala Asp Ser Ala Asn Ser Ser Met Asp
            180                 185                 190         
Lys Leu Leu Leu Gly Pro Ala Asp Arg Pro Ala Gly Arg
        195                 200                 205 


<210> 10
<211> 23
<212> DNA
<213> Homo sapiens

<400> 10
gatcatgggg tgggttttgt cag                                              23

<210> 11
<211> 22
<212> DNA
<213> Homo sapiens

<400> 11
gaggacttcc gctttcgcaa ca                                               22

<210> 12
<211> 183
<212> PRT
<213> Mus musculis

<400> 12
Ala Gly Ala Leu Arg Thr Gly Arg Arg Pro Ala Arg Pro Arg Asp Cys
 1               5                  10                  15      
Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala
            20                  25                  30          
Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg
        35                  40                  45              
Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Ala Ala Asp
    50                  55                  60                  
Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala
65                  70                  75                  80  
Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Phe Pro Arg Tyr Leu Pro Glu
                85                  90                  95      
Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Tyr Gly Glu Glu
            100                 105                 110         
Asp Phe Arg Phe Arg Ser Thr Pro Val Phe Ser Pro Ala Val Val Leu
        115                 120                 125             
Arg Arg Thr Ala Ala Cys Ala Gly Gly Arg Ser Val Tyr Ala Glu His
    130                 135                 140                 
Tyr Ile Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Asp Lys
145                 150                 155                 160 
Ser Ala Asp Ser Ala Asn Ser Ser Met Asp Lys Leu Leu Leu Gly Pro
                165                 170                 175     
Ala Asp Arg Pro Ala Gly Arg
            180             


<210> 13
<211> 30
<212> PRT
<213> Homo sapiens

<400> 13
Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly
 1               5                  10                  15      
Gly Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu
            20                  25                  30  


<210> 14
<211> 21
<212> PRT
<213> Homo sapiens

<400> 14
Gly Glu Glu Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr
 1               5                  10                  15      
Val Val Leu Arg Cys
            20      


<210> 15
<211> 34
<212> PRT
<213> Homo sapiens

<400> 15
Cys Val Pro Glu Pro Glu Lys Asp Ala Asp Ser Ile Asn Ser Ser Ile
 1               5                  10                  15      
Asp Lys Gln Gly Ala Lys Leu Leu Leu Gly Pro Asn Asp Ala Pro Ala
            20                  25                  30          
Gly Pro
        


<210> 16
<211> 2361
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (572)...(1202)

<400> 16
gaattcggca cgagggtcag ggaagtattc agtgctttgt tgtagagttg ttggatagag     60
gcacaggatc atttcatgtt gttgaggaga aaggagcaac agcctcctcc caccttatta    120
aaaatagaga tttaaaaaaa cctctaattt cctcgaagta cagaatctca agaggtagct    180
ctaaggagaa tccctctggg tttgagcgca ttcctcttcc agggggccta ttcttggact    240
gctttcctta atagagaaat ctctctgagc caaaatcggc ctcccccaat tccatcctgt    300
cggccccact tttctgctcc ggagacttcc aagccagtcc ccactcctcc ttcagccagt    360
cgggcccgca cccgcgcccg gcagggccag ccctctcctc ctcctgcgtg gcgcagcaca    420
ggccctgagc gcgcgacccc aggccctggg cgccccgccg catgctcgcg gctggaagcc    480
ccagtttgcg tggcccttcg ggttattccg ctcaagagcc gccgcgtcgc cccatctcgg    540
cgcgaatctg aaagcgcttt cgggggagaa g atg ttg ggg gca ctg gtc tgg       592
                                   Met Leu Gly Ala Leu Val Trp
                                    1               5
 
atg ctg gta gcc ggc ttc ctg ctg gcg ctg ccg ccg agc tgg gcc gcg      640
Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala
         10                  15                  20
 
ggc gcc ccg agg gcg ggc agg cgc ccc gcg cgg ccg cgg ggc tgc gcg      688
Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala
     25                  30                  35
 
gac cgg ccg gag gag cta ctg gag cag ctg tac ggg cgc ctg gcg gcc      736
Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala
 40                  45                  50                  55
 
ggc gtg ctc agt gcc ttc cac cac acg ctg cag ctg ggg ccg cgt gag      784
Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu
                 60                  65                  70
 
cag gcg cgc aac gcg agc tgc ccg gca ggg ggc agg ccc gcc gac cgc      832
Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg
             75                  80                  85
 
cgc ttc cgg ccg ccc acc aac ctg cgc agc gtg tcg ccc tgg gcc tac      880
Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr
         90                  95                 100
 
aga atc tcc tac gac ccg gcg agg tac ccc agg tac ctg cct gaa gcc      928
Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala
    105                 110                 115
 
tac tgc ctg tgc cgg ggc tgc ctg acc ggg ctg ttc ggc gag gag gac      976
Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp
120                 125                 130                 135
 
gtg cgc ttc cgc agc gcc cct gtc tac atg ccc acc gtc gtc ctg cgc     1024
Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg
                140                 145                 150
 
cgc acc ccc gcc tgc gcc ggc ggc cgt tcc gtc tac acc gag gcc tac     1072
Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr
            155                 160                 165
 
gtc acc atc ccc gtg ggc tgc acc tgc gtc ccc gag ccg gag aag gac     1120
Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp
        170                 175                 180
 
gca gac agc atc aac tcc agc atc gac aaa cag ggc gcc aag ctc ctg     1168
Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu
    185                 190                 195
 
ctg ggc ccc aac gac gcg ccc gct ggc ccc tga g gccggtcctg            1212
Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro  *
200                 205
 
ccccgggagg tctccccggc ccgcatcccg aggcgcccaa gctggagccg cctggagggc   1272
tcggtcggcg acctctgaag agagtgcacc gagcaaacca agtgccggag caccagcgcc   1332
gcctttccat ggagactcgt aagcagcttc atctgacacg ggaatccctg gcttgctttt   1392
agctacaagc aagcagcgtg gctggaagct gatgggaaac gacccggcac gggcatcctg   1452
tgtgcggccc gcatggaggg tttggaaaag ttcacggagg ctccctgagg agcctctcag   1512
atcggctgct gcgggtgcag ggcgtgactc accgctgggt gcttgccaaa gagataggga   1572
cgcatatgct ttttaaagca atctaaaaat aataataagt atagcgacta tatacctact   1632
tttaaaatca actgttttga atagaggcag agctatttta tattatcaaa tgagagctac   1692
tctgttacat ttcttaacat ataaacatcg ttttttactt cttctggtag aattttttaa   1752
agcataattg gaatccttgg ataaattttg tagctggtac actctggcct gggtctctga   1812
attcagcctg tcaccgatgg ctgactgatg aaatggacac gtctcatctg acccactctt   1872
ccttccactg aaggtcttca cgggcctcca ggtggaccaa agggatgcac aggcggctcg   1932
catgccccag ggccagctaa gagttccaaa gatctcagat ttggttttag tcatgaatac   1992
ataaacagtc tcaaactcgc acaatttttt cccccttttg aaagccactg gggccaattt   2052
gtggttaaga ggtggtgaga taagaagtgg aacgtgacat ctttgccagt tgtcagaaga   2112
atccaagcag gtattggctt agttgtaagg gctttaggat caggccgaat atgaggacaa   2172
agtgggccac gttagcatct gcagagatca atctggaggc ttctgtttct gcattctgcc   2232
acgagagcta ggtccttgat cttttcttta gattgaaagt ctgtctctga acacaattat   2292
ttgtaaaagt tagaagttct tttttaaatc attaaaagag gcttgctgaa aaaaaaaaaa   2352
aaaaaaaaa                                                           2361

<210> 17
<211> 209
<212> PRT
<213> Homo sapiens

<400> 17
Met Leu Gly Ala Leu Val Trp Met Leu Val Ala Gly Phe Leu Leu Ala
 1               5                  10                  15      
Leu Pro Pro Ser Trp Ala Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro
            20                  25                  30          
Ala Arg Pro Arg Gly Cys Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln
        35                  40                  45              
Leu Tyr Gly Arg Leu Ala Ala Gly Val Leu Ser Ala Phe His His Thr
    50                  55                  60                  
Leu Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala
65                  70                  75                  80  
Gly Gly Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg
                85                  90                  95      
Ser Val Ser Pro Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr
            100                 105                 110         
Pro Arg Tyr Leu Pro Glu Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr
        115                 120                 125             
Gly Leu Phe Gly Glu Glu Asp Val Arg Phe Arg Ser Ala Pro Val Tyr
    130                 135                 140                 
Met Pro Thr Val Val Leu Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg
145                 150                 155                 160 
Ser Val Tyr Thr Glu Ala Tyr Val Thr Ile Pro Val Gly Cys Thr Cys
                165                 170                 175     
Val Pro Glu Pro Glu Lys Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp
            180                 185                 190         
Lys Gln Gly Ala Lys Leu Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly
        195                 200                 205             
Pro
    


<210> 18
<211> 187
<212> PRT
<213> Homo sapiens

<400> 18
Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys
 1               5                  10                  15      
Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala
            20                  25                  30          
Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg
        35                  40                  45              
Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp
    50                  55                  60                  
Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala
65                  70                  75                  80  
Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu
                85                  90                  95      
Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu
            100                 105                 110         
Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu
        115                 120                 125             
Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala
    130                 135                 140                 
Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys
145                 150                 155                 160 
Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu
                165                 170                 175     
Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro
            180                 185         


<210> 19
<211> 54
<212> PRT
<213> Homo sapiens

<400> 19
Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly
 1               5                  10                  15      
Gly Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser
            20                  25                  30          
Val Ser Pro Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro
        35                  40                  45              
Arg Tyr Leu Pro Glu Ala
    50                  


<210> 20
<211> 16
<212> PRT
<213> Homo sapiens

<400> 20
Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val
 1               5                  10                  15      


<210> 21
<211> 57
<212> PRT
<213> Homo sapiens

<400> 21
Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala
 1               5                  10                  15      
Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys
            20                  25                  30          
Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu
        35                  40                  45              
Leu Leu Gly Pro Asn Asp Ala Pro Ala
    50                  55          


<210> 22
<211> 14
<212> PRT
<213> Homo sapiens

<400> 22
Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala
 1               5                  10                  


<210> 23
<211> 1861
<212> DNA
<213> homo sapiens

<400> 23
aaaatgtttt cagctcctgg aggcgaaagg tgcagagtcg ctctgtgtcc gtgaggccgg 60
gcggcgacct cgctcagtcg gcttctcggt ccgagtcccc gggtctggat gctggtagcc 120
ggcttcctgc tggcgctgcc gccgagctgg gccgcgggcg ccccgagggc gggcaggcgc 180
cccgcgcggc cgcggggctg cgcggaccgg ccggaggagc tactggagca gctgtacggg 240
cgcctggcgg ccggcgtgct cagtgccttc caccacacgc tgcagctggg gccgcgtgag 300
caggcgcgca acgcgagctg cccggcaggg ggcaggcccg ccgaccgccg cttccggccg 360
cccaccaacc tgcgcagcgt gtcgccctgg gcctacagaa tctcctacga cccggcgagg 420
taccccaggt acctgcctga agcctactgc ctgtgccggg gctgcctgac cgggctgttc 480
ggcgaggagg acgtgcgctt ccgcagcgcc cctgtctaca tgcccaccgt cgtcctgcgc 540
cgcacccccg cctgcgccgg cggccgttcc gtctacaccg aggcctacgt caccatcccc 600
gtgggctgca cctgcgtccc cgagccggag aaggacgcag acagcatcaa ctccagcatc 660
gacaaacagg gcgccaagct cctgctgggc cccaacgacg cgcccgctgg cccctgaggc 720
cggtcctgcc ccgggaggtc tccccggccc gcatcccgag gcgcccaagc tggagccgcc 780
tggagggctc ggtcggcgac ctctgaagag agtgcaccga gcaaaccaag tgccggagca 840
ccagcgccgc ctttccatgg agactcgtaa gcagcttcat ctgacacggg catccctggc 900
ttgcttttag ctacaagcaa gcagcgtggc tggaagctga tgggaaacga cccggcacgg 960
gcatcctgtg tgcggcccgc atggagggtt tggaaaagtt cacggaggct ccctgaggag 1020
cctctcagat cggctgctgc gggtgcaggg cgtgactcac cgctgggtgc ttgccaaaga 1080
gatagggacg catatgcttt ttaaagcaat ctaaaaataa taataagtat agcgactata 1140
tacctacttt taaaatcaac tgttttgaat agaggcagag ctattttata ttatcaaatg 1200
agagctactc tgttacattt cttaacatat aaacatcgtt ttttacttct tctggtagaa 1260
ttttttaaag cataattgga atccttggat aaattttgta gctggtacac tctggcctgg 1320
gtctctgaat tcagcctgtc accgatggct gactgatgaa atggacacgt ctcatctgac 1380
ccactcttcc ttccactgaa ggtcttcacg ggcctccagg tggaccaaag ggatgcacag 1440
gcggctcgca tgccccaggg ccagctaaga gttccaaaga tctcagattt ggttttagtc 1500
atgaatacat aaacagtctc aaactcgcac aattttttcc cccttttgaa agccactggg 1560
gccaatttgt ggttaagagg tggtgagata agaagtggaa cgtgacatct ttgccagttg 1620
tcagaagaat ccaagcaggt attggcttag ttgtaagggc tttaggatca ggctgaatat 1680
gaggacaaag tgggccacgt tagcatctgc agagatcaat ctggaggctt ctgtttctgc 1740
attctgccac gagagctagg tccttgatct tttctttaga ttgaaagtct gtctctgaac 1800
acaattattt gtaaaagtta gtagttcttt tttaaatcat taaaagaggc ttgctgaagg 1860
a                                                                 1861

<210> 24
<211> 202
<212> PRT
<213> homo sapiens

<400> 24
Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala
 1               5                  10                  15      
Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala
            20                  25                  30          
Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala
        35                  40                  45              
Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu
    50                  55                  60                  
Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg
65                  70                  75                  80  
Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr
                85                  90                  95      
Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala
            100                 105                 110         
Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp
        115                 120                 125             
Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg
    130                 135                 140                 
Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr
145                 150                 155                 160 
Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp
                165                 170                 175     
Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu
            180                 185                 190         
Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro
        195                 200         


<210> 25
<211> 2330
<212> DNA
<213> homo sapiens

<400> 25
gtcagggaag tattcagtgc tttgttgtag agttgttgga tagaggcaca ggatcatttc 60
atgttgttga ggagaaagga gcaacagcct cctcccacct tattaaaaat agagatttaa 120
aaaaacctct aatttcctcg aagtacagaa tctcaagagg tagctctaag gagaatccct 180
ctgggtttga gcgcattcct cttccagggg gcctattctt ggactgcttt ccttaataga 240
gaaatctctc tgagccaaaa tcggcctccc ccaattccat cctgtcggcc ccacttttct 300
gctccggaga cttccaagcc agtccccact cctccttcag ccagtcgggc ccgcacccgc 360
gcccggcagg gccagccctc tcctcctcct gcgtggcgca gcacaggccc tgagcgcgcg 420
accccaggcc ctgggcgccc cgccgcatgc tcgcggctgg aagccccagt ttgcgtggcc 480
cttcgggtta ttccgctcaa gagccgccgc gtcgccccat ctcggcgcga atctgaaagc 540
gctttcgggg gagaagatgt tgggggcact ggtctggatg ctggtagccg gcttcctgct 600
ggcgctgccg ccgagctggg ccgcgggcgc cccgagggcg ggcaggcgcc ccgcgcggcc 660
gcggggctgc gcggaccggc cggaggagct actggagcag ctgtacgggc gcctggcggc 720
cggcgtgctc agtgccttcc accacacgct gcagctgggg ccgcgtgagc aggcgcgcaa 780
cgcgagctgc ccggcagggg gcaggcccgc cgaccgccgc ttccggccgc ccaccaacct 840
gcgcagcgtg tcgccctggg cctacagaat ctcctacgac ccggcgaggt accccaggta 900
cctgcctgaa gcctactgcc tgtgccgggg ctgcctgacc gggctgttcg gcgaggagga 960
cgtgcgcttc cgcagcgccc ctgtctacat gcccaccgtc gtcctgcgcc gcacccccgc 1020
ctgcgccggc ggccgttccg tctacaccga ggcctacgtc accatccccg tgggctgcac 1080
ctgcgtcccc gagccggaga aggacgcaga cagcatcaac tccagcatcg acaaacaggg 1140
cgccaagctc ctgctgggcc ccaacgacgc gcccgctggc ccctgaggcc ggtcctgccc 1200
cgggaggtct ccccggcccg catcccgagg cgcccaagct ggagccgcct ggagggctcg 1260
gtcggcgacc tctgaagaga gtgcaccgag caaaccaagt gccggagcac cagcgccgcc 1320
tttccatgga gactcgtaag cagcttcatc tgacacgggc atccctggct tgcttttagc 1380
tacaagcaag cagcgtggct ggaagctgat gggaaacgac ccggcacggg catcctgtgt 1440
gcggcccgca tggagggttt ggaaaagttc acggaggctc cctgaggagc ctctcagatc 1500
ggctgctgcg ggtgcagggc gtgactcacc gctgggtgct tgccaaagag atagggacgc 1560
atatgctttt taaagcaatc taaaaataat aataagtata gcgactatat acctactttt 1620
aaaatcaact gttttgaata gaggcagagc tattttatat tatcaaatga gagctactct 1680
gttacatttc ttaacatata aacatcgttt tttacttctt ctggtagaat tttttaaagc 1740
ataattggaa tccttggata aattttgtag ctggtacact ctggcctggg tctctgaatt 1800
cagcctgtca ccgatggctg actgatgaaa tggacacgtc tcatctgacc cactcttcct 1860
tccactgaag gtcttcacgg gcctccaggt ggaccaaagg gatgcacagg cggctcgcat 1920
gccccagggc cagctaagag ttccaaagat ctcagatttg gttttagtca tgaatacata 1980
aacagtctca aactcgcaca attttttccc ccttttgaaa gccactgggg ccaatttgtg 2040
gttaagaggt ggtgagataa gaagtggaac gtgacatctt tgccagttgt cagaagaatc 2100
caagcaggta ttggcttagt tgtaagggct ttaggatcag gctgaatatg aggacaaagt 2160
gggccacgtt agcatctgca gagatcaatc tggaggcttc tgtttctgca ttctgccacg 2220
agagctaggt ccttgatctt ttctttagat tgaaagtctg tctctgaaca caattatttg 2280
taaaagttag tagttctttt ttaaatcatt aaaagaggct tgctgaagga            2330

<210> 26
<211> 209
<212> PRT
<213> homo sapiens

<400> 26
Met Leu Gly Ala Leu Val Trp Met Leu Val Ala Gly Phe Leu Leu Ala
 1               5                  10                  15      
Leu Pro Pro Ser Trp Ala Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro
            20                  25                  30          
Ala Arg Pro Arg Gly Cys Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln
        35                  40                  45              
Leu Tyr Gly Arg Leu Ala Ala Gly Val Leu Ser Ala Phe His His Thr
    50                  55                  60                  
Leu Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala
65                  70                  75                  80  
Gly Gly Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg
                85                  90                  95      
Ser Val Ser Pro Trp Ala Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr
            100                 105                 110         
Pro Arg Tyr Leu Pro Glu Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr
        115                 120                 125             
Gly Leu Phe Gly Glu Glu Asp Val Arg Phe Arg Ser Ala Pro Val Tyr
    130                 135                 140                 
Met Pro Thr Val Val Leu Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg
145                 150                 155                 160 
Ser Val Tyr Thr Glu Ala Tyr Val Thr Ile Pro Val Gly Cys Thr Cys
                165                 170                 175     
Val Pro Glu Pro Glu Lys Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp
            180                 185                 190         
Lys Gln Gly Ala Lys Leu Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly
        195                 200                 205             
Pro
    


