                         SEQUENCE LISTING

<110>  Dow AgroSciences LLC
	 Webb, Steven Robert
       Henry, Matthew
 
<120>  Vaccine for Avian Influenza and Methods of Use

<130>  DAS-132XC1

<150>  US 60/793,804
<151>  2006-04-21

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  548
<212>  PRT
<213>  Avian influenza virus

<400>  1

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Lys Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Lys Glu His Asn Gly Lys Leu Cys Ser Leu Lys Gly Val Arg 
        35                  40                  45              


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Asp Asn Pro Thr Asn Gly Leu Cys Tyr Pro Gly Asp Phe Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys Tyr Leu Met Ser Asn Thr Asn His Phe Glu 
            100                 105                 110         


Lys Ile Gln Ile Ile Pro Arg Asn Ser Trp Ser Asn His Asp Ala Ser 
        115                 120                 125             


Ser Gly Val Ser Ser Ala Cys Pro Tyr Asn Gly Arg Ser Ser Phe Phe 
    130                 135                 140                 


Arg Ser Val Val Trp Leu Ile Lys Lys Ser Asn Val Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Thr Tyr Asn Asn Thr Asn Val Glu Asp Leu Leu Ile Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Glu Leu Tyr Gln 
            180                 185                 190         


Asn Ser Asn Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Ile Glu Phe Phe Trp Thr Ile Leu Arg Pro Asn Asp Ala Ile Ser 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Ala Ile Met Arg Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asp Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asp Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
305                 310                 315                 320 


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
                325                 330                 335     


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
            340                 345                 350         


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
        355                 360                 365             


Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
    370                 375                 380                 


Met Asn Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Asn Asn Leu Glu 
385                 390                 395                 400 


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
                405                 410                 415     


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
            420                 425                 430         


Thr Leu Asp Phe His Asp Ser Tyr Val Lys Asn Leu Tyr Asp Lys Val 
        435                 440                 445             


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Leu 
    450                 455                 460                 


Glu Phe Ser His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
465                 470                 475                 480 


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ser Arg Leu Asn Arg 
                485                 490                 495     


Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Thr Tyr Gln Ile 
            500                 505                 510         


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
        515                 520                 525             


Val Ala Gly Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
    530                 535                 540                 


Arg Ile Cys Ile 
545             


<210>  2
<211>  16
<212>  PRT
<213>  Avian influenza virus

<400>  2

Met Glu Arg Ile Val Ile Ala Leu Ala Ile Ile Ser Val Val Lys Gly 
1               5                   10                  15      


<210>  3
<211>  326
<212>  PRT
<213>  Avian influenza virus

<400>  3

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Lys Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Lys Glu His Asn Gly Lys Leu Cys Ser Leu Lys Gly Val Arg 
        35                  40                  45              


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Asp Asn Pro Thr Asn Gly Leu Cys Tyr Pro Gly Asp Phe Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys Tyr Leu Met Ser Asn Thr Asn His Phe Glu 
            100                 105                 110         


Lys Ile Gln Ile Ile Pro Arg Asn Ser Trp Ser Asn His Asp Ala Ser 
        115                 120                 125             


Ser Gly Val Ser Ser Ala Cys Pro Tyr Asn Gly Arg Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Ile Lys Lys Ser Asn Ala Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Thr Tyr Asn Asn Thr Asn Val Glu Asp Leu Leu Ile Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Glu Leu Tyr Gln 
            180                 185                 190         


Asn Ser Asn Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Ile Glu Phe Phe Trp Thr Ile Leu Arg Pro Asn Asp Ala Ile Ser 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Ala Ile Met Arg Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asp Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asp Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
305                 310                 315                 320 


Pro Gln Arg Glu Thr Arg 
                325     


<210>  4
<211>  184
<212>  PRT
<213>  Avian influenza virus

<400>  4

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly 
1               5                   10                  15      


Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu 
    50                  55                  60                  


Ala Val Gly Lys Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu 
65                  70                  75                  80  


Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            100                 105                 110         


Ser Tyr Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp 
        115                 120                 125             


Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro 
145                 150                 155                 160 


Gln Tyr Ser Glu Glu Ser Arg Leu Asn Arg Glu Glu Ile Asp Gly Val 
                165                 170                 175     


Lys Leu Glu Ser Met Gly Thr Tyr 
            180                 


<210>  5
<211>  28
<212>  PRT
<213>  Avian influenza virus

<400>  5

Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala 
1               5                   10                  15      


Ile Met Val Ala Gly Leu Ser Phe Trp Met Cys Ser 
            20                  25              


<210>  6
<211>  10
<212>  PRT
<213>  Avian influenza virus

<400>  6

Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
1               5                   10  


<210>  7
<211>  564
<212>  PRT
<213>  Avian influenza virus

<400>  7

Met Glu Arg Ile Val Ile Ala Leu Ala Ile Ile Ser Val Val Lys Gly 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Glu His Asn Gly Lys Leu Cys Ser Leu Lys Gly Val Arg 
    50                  55                  60                  


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Asp Asn Pro Val Asn Gly Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Met Ser Ser Thr Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Arg Ser Ser Trp Ser Asn His Asp Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Asn Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Thr Tyr Asn Asn Thr Asn Val Glu Asp Leu Leu Ile Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Thr Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Ser Asn Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Arg Pro Asn Asp Ala Ile Ser 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asp Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Val Val Gly Lys Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Arg Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ser Arg Leu Asn Arg 
            500                 505                 510         


Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Thr Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Val Ala Gly Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile 
                


<210>  8
<211>  16
<212>  PRT
<213>  Avian influenza virus

<400>  8

Met Glu Arg Ile Val Ile Ala Leu Ala Ile Ile Ser Val Val Lys Gly 
1               5                   10                  15      


<210>  9
<211>  326
<212>  PRT
<213>  Avian influenza virus

<400>  9

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Lys Glu His Asn Gly Lys Leu Cys Ser Leu Lys Gly Val Arg 
        35                  40                  45              


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Asp Asn Pro Val Asn Gly Leu Cys Tyr Pro Gly Asp Phe Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys His Leu Met Ser Ser Thr Asn His Phe Glu 
            100                 105                 110         


Lys Ile Gln Ile Ile Pro Arg Ser Ser Trp Ser Asn His Asp Ala Ser 
        115                 120                 125             


Ser Gly Val Ser Ser Ala Cys Pro Tyr Asn Gly Arg Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Ala Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Thr Tyr Asn Asn Thr Asn Val Glu Asp Leu Leu Ile Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Thr Glu Gln Thr Lys Leu Tyr Gln 
            180                 185                 190         


Asn Ser Asn Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Met Glu Phe Phe Trp Thr Ile Leu Arg Pro Asn Asp Ala Ile Ser 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asn Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asp Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
305                 310                 315                 320 


Pro Gln Arg Glu Thr Arg 
                325     


<210>  10
<211>  157
<212>  PRT
<213>  Avian influenza virus

<400>  10

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly 
1               5                   10                  15      


Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu 
    50                  55                  60                  


Val Val Gly Lys Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu 
65                  70                  75                  80  


Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            100                 105                 110         


Ser Asn Val Arg Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp 
        115                 120                 125             


Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr 
145                 150                 155         


<210>  11
<211>  24
<212>  PRT
<213>  Avian influenza virus

<400>  11

Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala 
1               5                   10                  15      


Ile Met Val Ala Gly Leu Ser Phe 
            20                  


<210>  12
<211>  10
<212>  PRT
<213>  Avian influenza virus

<400>  12

Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
1               5                   10  


