                              Sequence Listing

<110> Genentech, Inc.
      PHILLIPS, Heidi
      SOROCEANU, Liliana


<120> Method of Diagnosing and Treating Glioma

<130> P2430R1 WO


<150> US 60/867,761
<151> 2006-11-29

<160> 2

<210> 1
<211> 5621
<212> DNA
<213> Homo sapiens

<400> 1
 gtggctggag tccgggcaga gcttgagggc agttggtgcg gtcgggttgg 50

 ttcttacacc ccggcgggag cgcccagaca agccgagctg actggacttc 100

 tccggccggc cccattcccg aggctgcggc agcttcggtt ccgagaccga 150

 ccggagagga gcccgagtcc cggcctctgg gggattcgct ctctgcagac 200

 cagtgggacc ccgaaacttg aacgcaatct ccagccccct tttttgcctt 250

 cctttgtcac ttgcccgggt ttctcccaac gtgttctttt ttttcctctt 300

 cattctccct ccttcgaagg acacaaaagt ggcttccgcg gaaagatttg 350

 gaggcggtgg gagcttttct ccccggagag cgactgtgta gaaaggattt 400

 ttgggaagcc gctttttaac acctctgctc tccgtccccc aagcctctgt 450

 gtaatcctct gaggagaaaa gcccatagct tgaaagttcg ggggcatttt 500

 gttgtgttct gtaggagaga gggggaggac cctgttcggg tagtttggcc 550

 ggactggtac tggccgttgg aaaacccgaa gtacatttcc gtgtggaact 600

 tttgcagata tatattttta gatttttaaa taccagataa aaaatatatg 650

 ccttctatat atctcctggc gacctgcccc tgacagcgcg atgtacaata 700

 cggtgtggag tatggaccgc gatgacgcag actggaggga ggtgatgatg 750

 ccctattcga cagaactgat attttatatt gaaatggatc ctccagctct 800

 tccaccaaag ccacctaagc caatgacttc agcagttcca aatggaatga 850

 aggacagttc tgtttctctt caggatgcag aatggtactg gggggatatt 900

 tcaagggagg aggtaaatga caaattgcgg gatatgccag atgggacctt 950

 cttggtccga gatgcctcaa caaaaatgca gggagattat actttgactt 1000

 tgcggaaggg aggcaataat aagttaataa agatctatca ccgggatggt 1050

 aaatatggct tttctgatcc tctgacattt aattccgtgg tggagctcat 1100

 taaccactat caccatgaat ctcttgctca gtacaatccc aaacttgatg 1150

 tgaagctgat gtacccagtg tccagatacc aacaggatca gttggtaaaa 1200

 gaagataata ttgatgcagt aggtaaaaaa ctgcaagaat accactctca 1250

 gtatcaggag aagagtaaag agtatgatag gctgtatgaa gaatatacta 1300

 gaacatccca ggaaatacag atgaagagga ctgcaataga agcttttaat 1350

 gaaacaatta aaatatttga agagcagtgt cacacacaag aacaacatag 1400

 caaagaatat attgagcgat ttcgcagaga ggggaatgaa aaggagattg 1450

 aacgaattat gatgaattat gataaattga aatcacgtct gggtgagatt 1500

 catgatagca aaatgcgtct agagcaggat ttgaagaatc aagctttgga 1550

 caaccgagaa atagataaaa aaatgaatag catcaaacct gacctgatcc 1600

 agctgcgaaa gatccgagat caacaccttg tatggctcaa tcacaaagga 1650

 gtgagacaga aacgcctgaa tgtctggctg ggaattaaga atgaggatgc 1700

 tgctgagaac tattttatca atgaggaaga tgaaaacctg ccccattatg 1750

 atgagaaaac ctggtttgtt gaggatatca atcgagtaca agcagaggac 1800

 ttgctttatg ggaaacctga tggtgcattc ttaattcgtg agagtagcaa 1850

 gaaaggatgc tatgcttgct ctgtggtggc cgatggggaa gtgaagcact 1900

 gtgtgatcta cagcactgct cggggctatg gctttgcaga gccctacaac 1950

 ctgtacagct ctctgaagga gctagtgctc cattaccagc agacatcctt 2000

 ggttcagcac aacgactccc tcaacgtcag gcttgcctac cctgttcatg 2050

 cacagatgcc ctcgctttgc agataaagag gaagtgggaa gagaggtggt 2100

 tctctggcat ttttttctac agtttttatt agactacgat gagggcattc 2150

 tttctacata gactgcttgt tttgcacaag aagtgatttt gtgaatgtga 2200

 agtggagagg ccgagcagca gccggccggg atgggggcat tagaggcctg 2250

 aggttctcta ggactcagcc atgccgctgc actgacatac taagctggaa 2300

 gcagatgttt tttttgaaag tctgtttcat tggggttttt gttttgttta 2350

 gccagacacc ctcaacagaa tattaggctt gatggttata gcgggtgggg 2400

 ttgtatttgg aagcctctga agagaccatg tctttttaaa atctaactct 2450

 tgagagtgca gcaggggcat ggctctgctg ggagttgtgt tttgctttgg 2500

 cagtctctct tccccccacg aagaaggctg tttaggtttt gtgatagaat 2550

 gggatttgat gaaaaagaca accaaaggaa aatggggagg cttgggattt 2600

 catttaaata atctaagcca agatgataaa aaaaaccttc aactgaaggt 2650

 attttgtttc ttaccaacat aatttaggct tcagcatctc accagcccct 2700

 ccctctgaag aagtattatg ttcagaagcc aacaaaacag tttgttgcca 2750

 gaccaatgtt tgatgggaaa acgtggcact catagttgaa tgtatacttc 2800

 tgtaccaaaa cttgaacata aaaagactag aatttgtgag ttttagcaaa 2850

 cgctaaaatt gatcactgta actaacccct tctgtccttc ctgcctgttt 2900

 ctctgagatg aggaatagca ttctttttgt ggggatggtg agctttgaat 2950

 cataaaatga agttggtgct tgtatggtgt ttccttagcc taaagaatga 3000

 tctgttgttt gaaacctttg taacttgttt gtatgagtaa agaaaaggtg 3050

 caatgcagtg cttttagatg gcttgatata ccaaataaca atatagaaca 3100

 acattattat atgtgcttcc ccaagtttaa aggccctgca gaaatagtaa 3150

 acatggttta atttcccttc atttccccct cctttgctgg atggggtttt 3200

 gggagctata ggttgctaag gaggggagtc agattgtggt caggtgcctc 3250

 agtaaatcac agacccaggg gccctgtggt ccagggtgag agtcacacca 3300

 cattacacat gtgcttccat acagtggttt ctgaagcttt tgcagggaga 3350

 gaagatggct tagtgtttag actgttagta gaagccatct ggaagctttt 3400

 ctctttgcct ttttttgtga tcctgccatt aaggctatgt gcagtctgcc 3450

 ctcctgctcc agtggccttg attttaggcc aggaatcttc tgctccatgt 3500

 ggcttaagcc ttccagctga gtgaagctag gcaaatggag tgggggcagg 3550

 catctattcc tgcccccatc atgccccaca cccatcagtc aacactcatt 3600

 tgacaaatag agtccagctg cctctgagcc aatcctggga ccataatagg 3650

 ctcagagtga gtcagctgtt tgaacccaaa gctgtgcagt caggcaccct 3700

 ggctgagcta gagaagccag tacctgcatc ttggtttata aggcttacag 3750

 ctaggaaagc tctagttctg ggggtgaaag aaaaatatta gtttacctga 3800

 gcacttattt ccatgacagg gtctaaaata tggaccatga tgtagacaca 3850

 gatttttaat tttggaaaaa cctccagtta ctagtgacga ggatagaaag 3900

 ggaagtgctt ctctttggct ttttcttggt tacactgcag tttcaggatt 3950

 gggtgagaca gagacaaatg aacccccctc taaagtcatt taactaatag 4000

 ccagcacatc ccttccccaa actgtcaatt gaaatcttaa ctgaaagttt 4050

 tactgaataa taccaagcta attgctgttg ggcacacctg gatggctttg 4100

 cacctggtgt tgaacctgct gaagcaggtg gatgctcaag attacgtgca 4150

 aggaatccct cccatctggt actaaaattt cagtgtgttc tgagtgtctt 4200

 ttaaaccaaa atggaaatac agatacaggg ctgtagtatt cagtaatgtg 4250

 tctgctcctt gttgggcaga caccagcggt gtgcagggag agaccaagta 4300

 ccatctttat ctacacttgg gctggcttgt ggagaagggc tgcttttttc 4350

 agtcctacat tccttcattt tttttttcat tcttgaattc attgttttgt 4400

 gggatctaag acccaggggt catttgagag gtttgacagt atcttttctg 4450

 accagttgcc acatgacttg cttgaccctg agcctgtgga aatggcatag 4500

 ggaccagtct actacccact gggcctggtg tgtagagggg gagagggtag 4550

 caaggtgctt ctctacgccc atgacttggg agcaggtctt ggcctccttc 4600

 atgagagtct agtgccatgt cctgtcccat gatctggacc ctgggactgt 4650

 cttggcatct taactgcagt ttcaatgagg cagagggcaa agagagacca 4700

 agatcagagg ggttcattat acccctggct agagaaccca gctactgaca 4750

 tgcaagcagc ttggggctgg ctggacacag gtactaggcc cattgtttcc 4800

 aggtgaagct ttcatcacag aacagtgttg tctccacctg gccttagatg 4850

 gcacgccatg attcgggcct ggatagactg cctgcgtcct taccactgat 4900

 ctggccaaga atgaggccct cccaacactt tcactccctc tccaagcctt 4950

 gatgggacct ccacttattt aggcctcatg tgctttgaag aagctttgag 5000

 agccaatgtg tcttccacgg gtctcttttt tgctacaagt aatcagcccc 5050

 atgtgttctc ttaaactgag aattgcacct gggcaattcc tgttttctaa 5100

 ggtggtctct gctgctattt aacaacccag agtaggcctc tgtgaggctt 5150

 cagtggcctc agaaaccaga gggtccagat agggggcctg cttgggccct 5200

 ctgctgccaa ctgctcaaac ctgctttagc tccagccact tgtggcaaac 5250

 aacctcgttt ccttacaaat tccagcatgt gactttggtg ccgttacttg 5300

 tgaaaaatct attctgttgt ctttgatgtg tccaagaaaa ttcgtgtagt 5350

 ttacgtaaaa atatctgact cacaagaaag ccaactgtat gtcttgtgat 5400

 gggacagttc ataatgtagt tgctagacca ctttacaaat tgttcttgtc 5450

 accagatgtg ttcagacatt gctgtgcaat tgttggggag ggtaggggga 5500

 aaggcgagag gagatactta ttggtctttt tgtttaatac cttccccaag 5550

 aggggacagt ctggccaact tgctccagta atgcaataaa gacattgcaa 5600

 taaagtaaaa aaaaaaaaaa  a 5621

<210> 2
<211> 461
<212> PRT
<213> Homo sapiens

<400> 2
 Met Tyr Asn Thr Val Trp Ser Met Asp Arg Asp Asp Ala Asp Trp
   1               5                  10                  15

 Arg Glu Val Met Met Pro Tyr Ser Thr Glu Leu Ile Phe Tyr Ile
                  20                  25                  30

 Glu Met Asp Pro Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Met
                  35                  40                  45

 Thr Ser Ala Val Pro Asn Gly Met Lys Asp Ser Ser Val Ser Leu
                  50                  55                  60

 Gln Asp Ala Glu Trp Tyr Trp Gly Asp Ile Ser Arg Glu Glu Val
                  65                  70                  75

 Asn Asp Lys Leu Arg Asp Met Pro Asp Gly Thr Phe Leu Val Arg
                  80                  85                  90

 Asp Ala Ser Thr Lys Met Gln Gly Asp Tyr Thr Leu Thr Leu Arg
                  95                 100                 105

 Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Tyr His Arg Asp Gly
                 110                 115                 120

 Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Asn Ser Val Val Glu
                 125                 130                 135

 Leu Ile Asn His Tyr His His Glu Ser Leu Ala Gln Tyr Asn Pro
                 140                 145                 150

 Lys Leu Asp Val Lys Leu Met Tyr Pro Val Ser Arg Tyr Gln Gln
                 155                 160                 165

 Asp Gln Leu Val Lys Glu Asp Asn Ile Asp Ala Val Gly Lys Lys
                 170                 175                 180

 Leu Gln Glu Tyr His Ser Gln Tyr Gln Glu Lys Ser Lys Glu Tyr
                 185                 190                 195

 Asp Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln
                 200                 205                 210

 Met Lys Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile
                 215                 220                 225

 Phe Glu Glu Gln Cys His Thr Gln Glu Gln His Ser Lys Glu Tyr
                 230                 235                 240

 Ile Glu Arg Phe Arg Arg Glu Gly Asn Glu Lys Glu Ile Glu Arg
                 245                 250                 255

 Ile Met Met Asn Tyr Asp Lys Leu Lys Ser Arg Leu Gly Glu Ile
                 260                 265                 270

 His Asp Ser Lys Met Arg Leu Glu Gln Asp Leu Lys Asn Gln Ala
                 275                 280                 285

 Leu Asp Asn Arg Glu Ile Asp Lys Lys Met Asn Ser Ile Lys Pro
                 290                 295                 300

 Asp Leu Ile Gln Leu Arg Lys Ile Arg Asp Gln His Leu Val Trp
                 305                 310                 315

 Leu Asn His Lys Gly Val Arg Gln Lys Arg Leu Asn Val Trp Leu
                 320                 325                 330

 Gly Ile Lys Asn Glu Asp Ala Ala Glu Asn Tyr Phe Ile Asn Glu
                 335                 340                 345

 Glu Asp Glu Asn Leu Pro His Tyr Asp Glu Lys Thr Trp Phe Val
                 350                 355                 360

 Glu Asp Ile Asn Arg Val Gln Ala Glu Asp Leu Leu Tyr Gly Lys
                 365                 370                 375

 Pro Asp Gly Ala Phe Leu Ile Arg Glu Ser Ser Lys Lys Gly Cys
                 380                 385                 390

 Tyr Ala Cys Ser Val Val Ala Asp Gly Glu Val Lys His Cys Val
                 395                 400                 405

 Ile Tyr Ser Thr Ala Arg Gly Tyr Gly Phe Ala Glu Pro Tyr Asn
                 410                 415                 420

 Leu Tyr Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln Gln Thr
                 425                 430                 435

 Ser Leu Val Gln His Asn Asp Ser Leu Asn Val Arg Leu Ala Tyr
                 440                 445                 450

 Pro Val His Ala Gln Met Pro Ser Leu Cys Arg
                 455                 460    

