
                                SEQUENCE LISTING

<110> University of Utah Research Foundation

<120> METHODS AND COMPOSITIONS RELATED TO
  HIF-1 Alpha

<130> 21101.0087P1

<140> Unassigned          
<141> 2007-12-03  

<150> 60/868,188          
<151> 2006-12-01  

<160> 31

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 826
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 1
Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu
 1               5                  10                  15      
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys
            20                  25                  30          
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His
        35                  40                  45              
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile
    50                  55                  60                  
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile
65                  70                  75                  80  
Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu
                85                  90                  95      
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile
            100                 105                 110         
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr
        115                 120                 125             
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met
    130                 135                 140                 
Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu
145                 150                 155                 160 
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr
                165                 170                 175     
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu
            180                 185                 190         
His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro
        195                 200                 205             
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys
    210                 215                 220                 
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys
225                 230                 235                 240 
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp
                245                 250                 255     
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly
            260                 265                 270         
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr
        275                 280                 285             
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln
    290                 295                 300                 
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln
305                 310                 315                 320 
Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val
                325                 330                 335     
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe
            340                 345                 350         
Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp
        355                 360                 365             
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser
    370                 375                 380                 
Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu
385                 390                 395                 400 
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn
                405                 410                 415     
Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn
            420                 425                 430         
Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu
        435                 440                 445             
Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser
    450                 455                 460                 
Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro
465                 470                 475                 480 
Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp
                485                 490                 495     
Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu
            500                 505                 510         
Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val
        515                 520                 525             
Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr
    530                 535                 540                 
Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu
545                 550                 555                 560 
Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser
                565                 570                 575     
Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser
            580                 585                 590         
Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln
        595                 600                 605             
Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu
    610                 615                 620                 
Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala
625                 630                 635                 640 
Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser
                645                 650                 655     
Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala
            660                 665                 670         
Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro
        675                 680                 685             
Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu
    690                 695                 700                 
Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg
705                 710                 715                 720 
Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr
                725                 730                 735     
Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp
            740                 745                 750         
Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln
        755                 760                 765             
Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly
    770                 775                 780                 
Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Asp Cys
785                 790                 795                 800 
Glu Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu
                805                 810                 815     
Glu Leu Leu Arg Ala Leu Asp Gln Val Asn
            820                 825     


<210> 2
<211> 1698
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 2
tactagtgcc acatcatcac catatagaga tactcaaagt cggacagcct caccaaacag 60
agcaggaaaa ggagtcatag aacagacaga aaaatctcat ccaagaagcc ctaacgtgtt 120
atctgtcgct ttgagtcaaa gaactacagt tcctgaggaa gaactaaatc caaagatact 180
agctttgcag aatgctcaga gaaagcgaaa aatggaacat gatggttcac tttttcaagc 240
agtaggaatt ggaacattat tacagcagcc agacgatcat gcagctacta catcactttc 300
ttggaaacgt gtaaaaggat gcaaatctag tgaacagaat ggaatggagc aaaagacaat 360
tattttaata ccctctgatt tagcatgtag actgctgggg caatcaatgg atgaaagtgg 420
attaccacag ctgaccagtt atgattgtga agttaatgct cctatacaag gcagcagaaa 480
cctactgcag ggtgaagaat tactcagagc tttggatcaa gttaactgag ctttttctta 540
atttcattcc tttttttgga cactggtggc tcactaccta aagcagtcta tttatatttt 600
ctacatctaa ttttagaagc ctggctacaa tactgcacaa acttggttag ttcaattttt 660
gatccccttt ctacttaatt tacattaatg ctctttttta gtatgttctt taatgctgga 720
tcacagacag ctcattttct cagttttttg gtatttaaac cattgcattg cagtagcatc 780
attttaaaaa atgcaccttt ttatttattt atttttggct agggagttta tccctttttc 840
gaattatttt taagaagatg ccaatataat ttttgtaaga aggcagtaac ctttcatcat 900
gatcataggc agttgaaaaa tttttacacc ttttttttca cattttacat aaataataat 960
gctttgccag cagtacgtgg tagccacaat tgcacaatat attttcttaa aaaataccag 1020
cagttactca tggaatatat tctgcgttta taaaactagt ttttaagaag aaattttttt 1080
tggcctatga aattgttaaa cctggaacat gacattgtta atcatataat aatgattctt 1140
aaatgctgta tggtttatta tttaaatggg taaagccatt tacataatat agaaagatat 1200
gcatatatct agaaggtatg tggcatttat ttggataaaa ttctcaattc agagaaatca 1260
tctgatgttt ctatagtcac tttgccagct caaaagaaaa caatacccta tgtagttgtg 1320
gaagtttatg ctaatattgt gtaactgata ttaaacctaa atgttctgcc taccctgttg 1380
gtataaagat attttgagca gactgtaaac aagaaaaaaa aaatcatgca ttcttagcaa 1440
aattgcctag tatgttaatt tgctcaaaat acaatgtttg attttatgca ctttgtcgct 1500
attaacatcc tttttttcat gtagatttca ataattgagt aattttagaa gcattatttt 1560
aggaatatat agttgtcaca gtaaatatct tgttttttct atgtacattg tacaaatttt 1620
tcattccttt tgctctttgt ggttggatct aacactaact gtattgtttt gttacatcaa 1680
ataaacatct tctgtgga                                               1698

<210> 3
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 3
Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys Arg Gly Gly
 1               5                  10                  15      
Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn Thr Lys Asn
            20                  25                  30          


<210> 4
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 4
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Gly Val Trp
 1               5                  10                  15      
Leu Glu Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu
            20                  25                  30  


<210> 5
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 5
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Gly Val Trp
 1               5                  10                  15      
Leu Glu Thr Gln Gly Val Val Ile Tyr Asn Pro Arg Asn Leu
            20                  25                  30  


<210> 6
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 6
atttatctaa ttgtcccatc tctccactgc tgct                             34

<210> 7
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 7
tcttgaggaa cggatcagat gtc                                         23

<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 8
agtaggccct tgataaagaa tgga                                        24

<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 9
aactgatgac cagcaacttg a                                           21

<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 10
aacagcatct ttgatagcag t                                           21

<210> 11
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 11
gcagagaggt ttttatccta aatgggtg                                    28

<210> 12
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 12
cagcaccatg gctcgctcct ttaat                                       25

<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 13
catcttggcc tcccagactg ctgg                                        24

<210> 14
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 14
ccagttatgt agtttcgtgc gtttgc                                      26

<210> 15
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 15
gcaaacgcac gaaactacat aactgg                                      26

<210> 16
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 16
taccgggaaa ataggccccg aggctt                                      26

<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 17
attggcaaag atctatgtag ag                                          22

<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 18
tgccctacca gatggcaaaa t                                           21

<210> 19
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 19
ccggaattct caaccacagt gcattg                                      26

<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 20
cgggatccat acggtctttt gtcactg                                     27

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 21
aagccttgga gggtttcatt                                             20

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 22
tgctggattg gttcacacat                                             20

<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 23
gtggggcgcc ccaggcacca                                             20

<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 24
ctccttaatg tcacgcacga tttc                                        24

<210> 25
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 25
ctgggacttc catgccttaa ac                                          22

<210> 26
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 26
gccctgggct ccaacct                                                17

<210> 27
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 27
acctcccaca ctcc                                                   14

<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 28
cagacctcca caggtcttcc                                             20

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 29
cagaaaacca agccgaccta                                             20

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 30
aactctgtca cccaggcaac                                             20

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Aritficial Sequence; note =
      synthetic construct

<400> 31
gctcacacct gtgattccaa                                             20
