                         SEQUENCE LISTING

<110>  Medarex, Inc.
       Coccia, Marco A.
       Terrett, Jonathon A. 
       King, David John
       Pan, Chin
       Cardarelli, Josephine
       Yamanaka, Mark
       Henning, Karla Ann 
 
<120>  HUMAN ANTIBODIES THAT BIND CD70 AND USES THEREOF

<130>  077375.0533

<150>  US 60/870,091
<151>  2006-12-14

<150>  US 60/915,314
<151>  2007-05-01

<150>  US 60/991,702
<151>  2007-11-30

<160>  92    

<170>  PatentIn version 3.4

<210>  1
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45               


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Tyr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Pro Tyr Ser Asn Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ile Met Val Arg Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  4
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ile Met Val Arg Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  5
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Asp 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Gly Asp Tyr Gly Gly Asn Cys Phe Asp Tyr Trp 
            100                 105                 110         

 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Asp Ser Gly Gly Arg Thr Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Tyr Ser Asn Tyr Leu Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Tyr Ile Met His 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Tyr Tyr Ala Met His 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Tyr Gly Met His 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp His Gly Met His 
1               5   


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Asp Tyr Tyr Tyr Trp Ser 
1               5           
 

<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Tyr Ala Met Ser 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  19

Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  20

Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  23

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ile Ser Asp Ser Gly Gly Arg Thr Tyr Phe Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Thr Asp Gly Tyr Asp Phe Asp Tyr 
1               5                   


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Gly Pro Tyr Ser Asn Tyr Leu Asp Tyr 
1               5                   10  


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Asp Ser Ile Met Val Arg Gly Asp Tyr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Ser Ile Met Val Arg Gly Asp Tyr 
1               5                   


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Asp Gly Asp Tyr Gly Gly Asn Cys Phe Asp Tyr 
1               5                   10          


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Val Asp Tyr Ser Asn Tyr Leu Phe Phe Asp Tyr 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  36
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Ala Ser Gln Ser Ile Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  37
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  38 

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Gln Arg Thr Asn Trp Pro Leu Thr 
1               5                   


<210>  44
<211>  9 
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Gln Phe Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  47

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  49
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  49
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cctctggatt taccttcagt agctatatta tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagaaa caaatactac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatacg    300

gatggctacg attttgacta ctggggccag ggaaccctgg tcaccgtctc ctca          354


<210>  50
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  50
caaatacaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcggt tactatgcta tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcat taaatactac    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagagggc    300

ccttacagta actaccttga ctactggggc cagggaaccc tggtcaccgt ctcctca       357


<210>  51
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  51
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcga cgtctggatt caccttcagt gactatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa aacgctgtct    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattct    300

attatggttc ggggggacta ctggggccag ggaaccctgg tcaccgtctc ctca          354


<210>  52
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  52
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagc gaccatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattct    300

attatggttc ggggggacta ctggggccag ggaaccctgg tcaccgtctc ctca          354


<210>  53
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  53
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccgtcagc agtgattatt actactggag ctggatccgg    120

cagcccccag ggaagggact ggagtggctt gggtatatct attacagtgg gagcaccaac    180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc    240

tccctgaagc tgaggtctgt gaccactgcg gacacggccg tgtattactg tgcgagaggg    300

gatggggact acggtggtaa ctgttttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  54
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  54
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc atctatgcca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtgata gtggtggtcg cacatacttc    180

gcagactccg tgaggggccg gttcaccatc tccagagaca attccaagaa cacgctgtct    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaggtcgac    300

tacagtaact acctattctt tgactactgg ggccagggaa ccctggtcac cgtctcctca    360


<210>  55
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  55
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtaccaact ggccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  56
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  56
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca    120

gggaaagctc ctaagttctt gatctatgat gcctccagtt tggaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccattcac tttcggccct    300

gggaccaaag tggatatcaa a                                              321


<210>  57
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  57
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca    120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  58
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  58
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca    120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  59
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  59
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctttgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcaa cgtagcaact ggccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  60
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  60
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtattagc agcagctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgta cacttttggc    300

caggggacca agctggagat caaa                                           324


<210>  61
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  62
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  63
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  63

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly  
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg 
            


<210>  64
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  65
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
                85                  90                  


<210>  66
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro 
                85                  90                  95  


<210>  67
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95  


<210>  68
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


<210>  69
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  69

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  70
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  70

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  71
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  71

Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
1               5                   10          


<210>  72
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  72

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  73
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Asp 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Gly Asp Tyr Gly Gly Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  74
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  74
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccgtcagc agtgattatt actactggag ctggatccgg    120

cagcccccag ggaagggact ggagtggctt gggtatatct attacagtgg gagcaccaac    180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc    240

tccctgaagc tgaggtctgt gaccactgcg gacacggccg tgtattactg tgcgagaggg    300

gatggggact acggtggtaa ctattttgac tactggggcc agggaaccct ggtcaccgtc    360
 
tcctca                                                               366


<210>  75
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Asp Gly Asp Tyr Gly Gly Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  76
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  77
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  77

Ala Leu Ala Leu 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  78

Ala Leu Ala Leu 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  79

Gly Phe Leu Gly 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  80

Pro Arg Phe Lys 
1               


<210>  81
<211>  4
<212>  PRT 
<213>  Artificial

<220>
<223>  Peptide linker

<400>  81

Thr Arg Leu Arg 
1               


<210>  82
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  82

Ser Lys Gly Arg 
1               


<210>  83 
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  83

Pro Asn Asp Lys 
1               


<210>  84
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  84

Pro Val Gly Leu Ile Gly 
1               5       


<210>  85
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  85

Gly Pro Leu Gly Val 
1               5   


<210>  86
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  86

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  87
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  87

Pro Leu Gly Leu 
1               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  88

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  89

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  90
<211>  9
<212>  PRT
<213>  Cytomegalovirus

<400>  90

Ile Pro Ser Ile Asn Val His His Tyr 
1               5                   


<210>  91
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  91

Leu Leu Gly Leu  
1                           


<210>  92
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  92

Ala Leu Ala Leu
1                           

