                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary of the Department of Health and Human Services
       Cohen, Jeffrey
       Pesnicak, Lesley
 
<120>  RECOMBINANT VIRUS WITH DIMINISHED LATENCY AND METHODS OF USING 
       SAME

<130>  11613.83WOU1

<140>  NEW FILING
<141>  2007-11-06

<150>  60/857,766
<151>  2006-11-09

<160>  11    

<170>  PatentIn version 3.3

<210>  1
<211>  3615
<212>  DNA
<213>  Virus ORF29

<400>  1
atggaaaata ctcagaagac tgtgacagtg cccacggggc ccctgggtta cgtttatgcg     60

tgccgggttg aagatttgga tctggaggaa atttcatttt tggccgctcg tagcacggac    120

tctgatttgg ctttattacc tttgatgcgt aatttgaccg tggaaaaaac ttttacatcc    180

agcctggcgg tggtttctgg agcacgcact acgggtcttg ccggagctgg tattacctta    240

aaactcacta ccagtcattt ctatccatct gtctttgtct ttcacggagg caaacacgtt    300

ttacccagct ccgcggcccc aaatctcaca cgcgcgtgta acgcggctcg agaacggttt    360

gggttttcac gctgccaagg gcctcctgtt gacggtgctg ttgagacgac cggcgctgag    420

atatgcaccc gccttggatt agagccagaa aatacaatat tatacttggt ggtcacggca    480

ttgtttaagg aagccgtatt tatgtgcaac gtgtttctgc attatggagg actcgatatt    540

gttcatatta accatgggga tgttatacgt ataccgttat ttccggtaca acttttcatg    600

cccgatgtta accgtctggt acccgaccca ttcaacactc atcacaggtc tatcggagag    660

ggttttgtat acccaacacc cttttataac accgggttgt gccatttaat acatgactgt    720

gttattgctc ccatggccgt tgccttgcgc gtcagaaatg taactgccgt cgcccgagga    780

gcggcccacc ttgcttttga tgaaaatcac gagggggcag tactcccccc tgacattacg    840

tacacgtatt ttcagtcctc ttcaagtgga accactaccg cccgtggagc gcgtcgaaac    900

gatgtcaact ccacgtctaa gcctagccca tcgggggggt ttgaaagacg gttggcgtct    960

attatggccg ctgacacagc cttgcacgca gaagttatat tcaacactgg aatttacgaa   1020

gaaactccaa cagatatcaa agaatggcca atgtttatag gcatggaggg cactttgcca   1080

aggctaaacg ctctggggtc atataccgct cgtgtggccg gggtcattgg tgcgatggtt   1140

ttcagcccaa attctgcgtt gtatctaact gaggtggagg atagcgggat gaccgaagcc   1200

aaggatgggg gaccgggtcc atcatttaat cgattttacc agtttgccgg acctcattta   1260

gctgcgaatc cccaaacaga tcgagatggc cacgttctat ccagtcagtc tacgggttca   1320

tcaaacacag agtttagcgt ggattatttg gcactcattt gtggatttgg agcacccctg   1380

ttggcgcgac tgctttttta tctagaacgc tgtgacgctg gtgcgtttac agggggtcac   1440

ggggatgcgt taaaatatgt tacggggacc tttgactctg aaattccatg tagtttatgt   1500

gaaaaacaca cgcggccggt atgcgctcac acaacagtac accgacttag acaacgcatg   1560

ccgcgatttg gacaagccac ccgtcaacct attggggtgt ttggaacaat gaacagccaa   1620

tatagcgact gcgatcctct aggaaactat gctccatatt taatccttcg aaaacccggg   1680

gatcaaacgg aagcagcaaa ggcaaccatg caggacactt atagggctac actagaacgc   1740

ttgtttatcg atctagaaca agagcgacta ctggatcgcg gtgccccatg ttcttccgag   1800

ggactatcgt ctgtcattgt ggatcatcca acgtttcgtc gcatattaga cacactgcgt   1860

gcgcgtatag aacagacaac aacacaattt atgaaagtgt tggttgagac ccgcgattat   1920

aagatccgtg aaggattatc cgaagccacc cattcaatgg cgttaacgtt tgatccatac   1980

tcaggagcat tttgtcccat taccaatttt ttagttaaac gaacacacct agccgtggta   2040

caagacttag cattaagcca atgtcattgt gtattttacg gacagcaagt tgaggggcgg   2100

aactttcgta accaattcca acctgttttg cggcggcgtt ttgttgacct gtttaatggg   2160

gggtttatat caacacgctc tataaccgta acattatctg aaggtcctgt atccgcccca   2220

aatccgacat tgggacaaga cgcgcccgcg gggcgtacct ttgatgggga tttagcgcgc   2280

gtaagcgtgg aagttattcg ggatatacga gttaaaaata gggtcgtttt ttcaggtaac   2340

tgtacaaatc tctctgaggc agcccgggca aggcttgtag gccttgcaag tgcgtaccaa   2400

cgccaagaaa aaagagtgga tatgttacac ggggccctag ggtttttgct taaacagttt   2460

cacggcctgt tatttcctcg gggtatgcca ccaaacagta aatcccccaa cccgcagtgg   2520

ttttggaccc tgttacaacg caaccagatg ccggcagata aacttacaca cgaagagatt   2580

accactattg cagctgttaa acggtttacc gaggaatatg cagcaataaa ctttattaat   2640

ctacccccaa cctgcatagg agaattagcc cagttttata tggcaaatct tattcttaaa   2700

tactgcgatc attcacagta ccttataaat accttaactt ctataattac gggtgccagg   2760

cgcccgcgtg acccatcatc cgttttgcat tggattcgta aagatgtcac gtccgccgcg   2820

gacatagaaa cccaagcaaa ggcgcttctt gaaaaaacgg aaaacttacc ggaattatgg   2880

actacggctt ttacttcaac tcatttagtc cgcgcggcca tgaatcaacg tcccatggtc   2940

gttttaggaa taagcattag taaatatcac ggagcggcag gaaacaaccg cgtctttcag   3000

gcagggaatt ggagcggttt aaacgggggt aaaaatgtat gcccgctatt tacatttgat   3060

cgcactcgcc gttttataat agcatgtcct agaggaggtt ttatctgccc cgtaacaggt   3120

ccctcgtcgg gaaatcgaga aaccacccta tccgaccaag ttcgcggtat aattgtcagt   3180

ggcggggcca tggttcaatt agccatatac gccacggttg tgcgtgcagt gggcgctcga   3240

gcacaacata tggcatttga cgactggtta agtcttacag acgatgagtt tttagccaga   3300

gacttggagg agttacacga ccagattatc caaaccctgg aaacgccctg gaccgtagaa   3360

ggcgctctag aagcagtaaa gattctagat gaaaaaacga cagcgggaga tggggaaacc   3420

cccacaaacc tagcatttaa ttttgattct tgtgaaccaa gccatgacac cacatctaac   3480

gtattaaaca tttcagggtc aaacatttca gggtcaactg tccctggtct taaacgaccc   3540

cccgaagatg acgaactctt tgatcttagt ggtattccca taaaacatgg gaacattaca   3600

atggaaatga tttaa                                                    3615


<210>  2
<211>  808
<212>  DNA
<213>  Virus ORF29 deletion

<400>  2
atggaaaata ctcagaagac tgtgacagtg cccacggggc ccctgggtta cgtttatgcg     60

tgcggaatta tggactacgg cttttacttc aactcattta gtccgcgcgg ccatgaatca    120

acgtcccatg gtcgttttag gaataagcat tagtaaatat cacggagcgg caggaaacaa    180

ccgcgtcttt caggcaggga attggagcgg tttaaacggg ggtaaaaatg tatgcccgct    240

atttacattt gatcgcactc gccgttttat aatagcatgt cctagaggag gttttatctg    300

ccccgtaaca ggtccctcgt cgggaaatcg agaaaccacc ctatccgacc aagttcgcgg    360

tataattgtc agtggcgggg ccatggttca attagccata tacgccacgg ttgtgcgtgc    420

agtgggcgct cgagcacaac atatggcatt tgacgactgg ttaagtctta cagacgatga    480

gtttttagcc agagacttgg aggagttaca cgaccagatt atccaaaccc tggaaacgcc    540

ctggaccgta gaaggcgctc tagaagcagt aaagattcta gatgaaaaaa cgacagcggg    600

agatggggaa acccccacaa acctagcatt taattttgat tcttgtgaac caagccatga    660

caccacatct aacgtattaa acatttcagg gtcaaacatt tcagggtcaa ctgtccctgg    720

tcttaaacga ccccccgaag atgacgaact ctttgatctt agtggtattc ccataaaaca    780

tgggaacatt acaatggaaa tgatttaa                                       808


<210>  3
<211>  1204
<212>  PRT
<213>  Virus ORF29

<400>  3

Met Glu Asn Thr Gln Lys Thr Val Thr Val Pro Thr Gly Pro Leu Gly 
1               5                   10                  15      


Tyr Val Tyr Ala Cys Arg Val Glu Asp Leu Asp Leu Glu Glu Ile Ser 
            20                  25                  30          


Phe Leu Ala Ala Arg Ser Thr Asp Ser Asp Leu Ala Leu Leu Pro Leu 
        35                  40                  45              


Met Arg Asn Leu Thr Val Glu Lys Thr Phe Thr Ser Ser Leu Ala Val 
    50                  55                  60                  


Val Ser Gly Ala Arg Thr Thr Gly Leu Ala Gly Ala Gly Ile Thr Leu 
65                  70                  75                  80  


Lys Leu Thr Thr Ser His Phe Tyr Pro Ser Val Phe Val Phe His Gly 
                85                  90                  95      


Gly Lys His Val Leu Pro Ser Ser Ala Ala Pro Asn Leu Thr Arg Ala 
            100                 105                 110         


Cys Asn Ala Ala Arg Glu Arg Phe Gly Phe Ser Arg Cys Gln Gly Pro 
        115                 120                 125             


Pro Val Asp Gly Ala Val Glu Thr Thr Gly Ala Glu Ile Cys Thr Arg 
    130                 135                 140                 


Leu Gly Leu Glu Pro Glu Asn Thr Ile Leu Tyr Leu Val Val Thr Ala 
145                 150                 155                 160 


Leu Phe Lys Glu Ala Val Phe Met Cys Asn Val Phe Leu His Tyr Gly 
                165                 170                 175     


Gly Leu Asp Ile Val His Ile Asn His Gly Asp Val Ile Arg Ile Pro 
            180                 185                 190         


Leu Phe Pro Val Gln Leu Phe Met Pro Asp Val Asn Arg Leu Val Pro 
        195                 200                 205             


Asp Pro Phe Asn Thr His His Arg Ser Ile Gly Glu Gly Phe Val Tyr 
    210                 215                 220                 


Pro Thr Pro Phe Tyr Asn Thr Gly Leu Cys His Leu Ile His Asp Cys 
225                 230                 235                 240 


Val Ile Ala Pro Met Ala Val Ala Leu Arg Val Arg Asn Val Thr Ala 
                245                 250                 255     


Val Ala Arg Gly Ala Ala His Leu Ala Phe Asp Glu Asn His Glu Gly 
            260                 265                 270         


Ala Val Leu Pro Pro Asp Ile Thr Tyr Thr Tyr Phe Gln Ser Ser Ser 
        275                 280                 285             


Ser Gly Thr Thr Thr Ala Arg Gly Ala Arg Arg Asn Asp Val Asn Ser 
    290                 295                 300                 


Thr Ser Lys Pro Ser Pro Ser Gly Gly Phe Glu Arg Arg Leu Ala Ser 
305                 310                 315                 320 


Ile Met Ala Ala Asp Thr Ala Leu His Ala Glu Val Ile Phe Asn Thr 
                325                 330                 335     


Gly Ile Tyr Glu Glu Thr Pro Thr Asp Ile Lys Glu Trp Pro Met Phe 
            340                 345                 350         


Ile Gly Met Glu Gly Thr Leu Pro Arg Leu Asn Ala Leu Gly Ser Tyr 
        355                 360                 365             


Thr Ala Arg Val Ala Gly Val Ile Gly Ala Met Val Phe Ser Pro Asn 
    370                 375                 380                 


Ser Ala Leu Tyr Leu Thr Glu Val Glu Asp Ser Gly Met Thr Glu Ala 
385                 390                 395                 400 


Lys Asp Gly Gly Pro Gly Pro Ser Phe Asn Arg Phe Tyr Gln Phe Ala 
                405                 410                 415     


Gly Pro His Leu Ala Ala Asn Pro Gln Thr Asp Arg Asp Gly His Val 
            420                 425                 430         


Leu Ser Ser Gln Ser Thr Gly Ser Ser Asn Thr Glu Phe Ser Val Asp 
        435                 440                 445             


Tyr Leu Ala Leu Ile Cys Gly Phe Gly Ala Pro Leu Leu Ala Arg Leu 
    450                 455                 460                 


Leu Phe Tyr Leu Glu Arg Cys Asp Ala Gly Ala Phe Thr Gly Gly His 
465                 470                 475                 480 


Gly Asp Ala Leu Lys Tyr Val Thr Gly Thr Phe Asp Ser Glu Ile Pro 
                485                 490                 495     


Cys Ser Leu Cys Glu Lys His Thr Arg Pro Val Cys Ala His Thr Thr 
            500                 505                 510         


Val His Arg Leu Arg Gln Arg Met Pro Arg Phe Gly Gln Ala Thr Arg 
        515                 520                 525             


Gln Pro Ile Gly Val Phe Gly Thr Met Asn Ser Gln Tyr Ser Asp Cys 
    530                 535                 540                 


Asp Pro Leu Gly Asn Tyr Ala Pro Tyr Leu Ile Leu Arg Lys Pro Gly 
545                 550                 555                 560 


Asp Gln Thr Glu Ala Ala Lys Ala Thr Met Gln Asp Thr Tyr Arg Ala 
                565                 570                 575     


Thr Leu Glu Arg Leu Phe Ile Asp Leu Glu Gln Glu Arg Leu Leu Asp 
            580                 585                 590         


Arg Gly Ala Pro Cys Ser Ser Glu Gly Leu Ser Ser Val Ile Val Asp 
        595                 600                 605             


His Pro Thr Phe Arg Arg Ile Leu Asp Thr Leu Arg Ala Arg Ile Glu 
    610                 615                 620                 


Gln Thr Thr Thr Gln Phe Met Lys Val Leu Val Glu Thr Arg Asp Tyr 
625                 630                 635                 640 


Lys Ile Arg Glu Gly Leu Ser Glu Ala Thr His Ser Met Ala Leu Thr 
                645                 650                 655     


Phe Asp Pro Tyr Ser Gly Ala Phe Cys Pro Ile Thr Asn Phe Leu Val 
            660                 665                 670         


Lys Arg Thr His Leu Ala Val Val Gln Asp Leu Ala Leu Ser Gln Cys 
        675                 680                 685             


His Cys Val Phe Tyr Gly Gln Gln Val Glu Gly Arg Asn Phe Arg Asn 
    690                 695                 700                 


Gln Phe Gln Pro Val Leu Arg Arg Arg Phe Val Asp Leu Phe Asn Gly 
705                 710                 715                 720 


Gly Phe Ile Ser Thr Arg Ser Ile Thr Val Thr Leu Ser Glu Gly Pro 
                725                 730                 735     


Val Ser Ala Pro Asn Pro Thr Leu Gly Gln Asp Ala Pro Ala Gly Arg 
            740                 745                 750         


Thr Phe Asp Gly Asp Leu Ala Arg Val Ser Val Glu Val Ile Arg Asp 
        755                 760                 765             


Ile Arg Val Lys Asn Arg Val Val Phe Ser Gly Asn Cys Thr Asn Leu 
    770                 775                 780                 


Ser Glu Ala Ala Arg Ala Arg Leu Val Gly Leu Ala Ser Ala Tyr Gln 
785                 790                 795                 800 


Arg Gln Glu Lys Arg Val Asp Met Leu His Gly Ala Leu Gly Phe Leu 
                805                 810                 815     


Leu Lys Gln Phe His Gly Leu Leu Phe Pro Arg Gly Met Pro Pro Asn 
            820                 825                 830         


Ser Lys Ser Pro Asn Pro Gln Trp Phe Trp Thr Leu Leu Gln Arg Asn 
        835                 840                 845             


Gln Met Pro Ala Asp Lys Leu Thr His Glu Glu Ile Thr Thr Ile Ala 
    850                 855                 860                 


Ala Val Lys Arg Phe Thr Glu Glu Tyr Ala Ala Ile Asn Phe Ile Asn 
865                 870                 875                 880 


Leu Pro Pro Thr Cys Ile Gly Glu Leu Ala Gln Phe Tyr Met Ala Asn 
                885                 890                 895     


Leu Ile Leu Lys Tyr Cys Asp His Ser Gln Tyr Leu Ile Asn Thr Leu 
            900                 905                 910         


Thr Ser Ile Ile Thr Gly Ala Arg Arg Pro Arg Asp Pro Ser Ser Val 
        915                 920                 925             


Leu His Trp Ile Arg Lys Asp Val Thr Ser Ala Ala Asp Ile Glu Thr 
    930                 935                 940                 


Gln Ala Lys Ala Leu Leu Glu Lys Thr Glu Asn Leu Pro Glu Leu Trp 
945                 950                 955                 960 


Thr Thr Ala Phe Thr Ser Thr His Leu Val Arg Ala Ala Met Asn Gln 
                965                 970                 975     


Arg Pro Met Val Val Leu Gly Ile Ser Ile Ser Lys Tyr His Gly Ala 
            980                 985                 990         


Ala Gly Asn Asn Arg Val Phe Gln  Ala Gly Asn Trp Ser  Gly Leu Asn 
        995                 1000                 1005             


Gly Gly  Lys Asn Val Cys Pro  Leu Phe Thr Phe Asp  Arg Thr Arg 
    1010                 1015                 1020             


Arg Phe  Ile Ile Ala Cys Pro  Arg Gly Gly Phe Ile  Cys Pro Val 
    1025                 1030                 1035             


Thr Gly  Pro Ser Ser Gly Asn  Arg Glu Thr Thr Leu  Ser Asp Gln 
    1040                 1045                 1050             


Val Arg  Gly Ile Ile Val Ser  Gly Gly Ala Met Val  Gln Leu Ala 
    1055                 1060                 1065             


Ile Tyr  Ala Thr Val Val Arg  Ala Val Gly Ala Arg  Ala Gln His 
    1070                 1075                 1080             


Met Ala  Phe Asp Asp Trp Leu  Ser Leu Thr Asp Asp  Glu Phe Leu 
    1085                 1090                 1095             


Ala Arg  Asp Leu Glu Glu Leu  His Asp Gln Ile Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Thr  Pro Trp Thr Val Glu  Gly Ala Leu Glu Ala  Val Lys Ile 
    1115                 1120                 1125             


Leu Asp  Glu Lys Thr Thr Ala  Gly Asp Gly Glu Thr  Pro Thr Asn 
    1130                 1135                 1140             


Leu Ala  Phe Asn Phe Asp Ser  Cys Glu Pro Ser His  Asp Thr Thr 
    1145                 1150                 1155             


Ser Asn  Val Leu Asn Ile Ser  Gly Ser Asn Ile Ser  Gly Ser Thr 
    1160                 1165                 1170             


Val Pro  Gly Leu Lys Arg Pro  Pro Glu Asp Asp Glu  Leu Phe Asp 
    1175                 1180                 1185             


Leu Ser  Gly Ile Pro Ile Lys  His Gly Asn Ile Thr  Met Glu Met 
    1190                 1195                 1200             


Ile 
    


<210>  4
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  4
gcctagctag ccaaaatgga aaatactcag aagactgtg                            39


<210>  5
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primers

<400>  5
gtcagaatgc ggccgcggga ggttaaatca tttccattg                            39


<210>  6
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotides

<400>  6
cggggcccct gggttacgtt tatgcgtgcc gggttgaaga tttggatctg gaggaaattt     60


<210>  7
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotides

<400>  7
ggcgcttctt gaaaaaacgg aaaacttacc ggaattatgg actacggctt ttacttcaac     60


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  ORF29 Primers

<400>  8
catttgaccc tgccaacaac                                                 20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  ORF29 Primers

<400>  9
tagtgcgtgc tccagaaacc                                                 20


<210>  10
<211>  1204
<212>  PRT
<213>  Virus ORF29

<400>  10

Met Glu Asn Thr Gln Lys Thr Val Thr Val Pro Thr Gly Pro Leu Gly 
1               5                   10                  15      


Tyr Val Tyr Ala Cys Arg Val Glu Asp Leu Asp Leu Glu Glu Ile Ser 
            20                  25                  30          


Phe Leu Ala Ala Arg Ser Thr Asp Ser Asp Leu Ala Leu Leu Pro Leu 
        35                  40                  45              


Met Arg Asn Leu Thr Val Glu Lys Thr Phe Thr Ser Ser Leu Ala Val 
    50                  55                  60                  


Val Ser Gly Ala Arg Thr Thr Gly Leu Ala Gly Ala Gly Ile Thr Leu 
65                  70                  75                  80  


Lys Leu Thr Thr Ser His Phe Tyr Pro Ser Val Phe Val Phe His Gly 
                85                  90                  95      


Gly Lys His Val Leu Pro Ser Ser Ala Ala Pro Asn Leu Thr Arg Ala 
            100                 105                 110         


Cys Asn Ala Ala Arg Glu Arg Phe Gly Phe Ser Arg Cys Gln Gly Pro 
        115                 120                 125             


Pro Val Asp Gly Ala Val Glu Thr Thr Gly Ala Glu Ile Cys Thr Arg 
    130                 135                 140                 


Leu Gly Leu Glu Pro Glu Asn Thr Ile Leu Tyr Leu Val Val Thr Ala 
145                 150                 155                 160 


Leu Phe Lys Glu Ala Val Phe Met Cys Asn Val Phe Leu His Tyr Gly 
                165                 170                 175     


Gly Leu Asp Ile Val His Ile Asn His Gly Asp Val Ile Arg Ile Pro 
            180                 185                 190         


Leu Phe Pro Val Gln Leu Phe Met Pro Asp Val Asn Arg Leu Val Pro 
        195                 200                 205             


Asp Pro Phe Asn Thr His His Arg Ser Ile Gly Glu Gly Phe Val Tyr 
    210                 215                 220                 


Pro Thr Pro Phe Tyr Asn Thr Gly Leu Cys His Leu Ile His Asp Cys 
225                 230                 235                 240 


Val Ile Ala Pro Met Ala Val Ala Leu Arg Val Arg Asn Val Thr Ala 
                245                 250                 255     


Val Ala Arg Gly Ala Ala His Leu Ala Phe Asp Glu Asn His Glu Gly 
            260                 265                 270         


Ala Val Leu Pro Pro Asp Ile Thr Tyr Thr Tyr Phe Gln Ser Ser Ser 
        275                 280                 285             


Ser Gly Thr Thr Thr Ala Arg Gly Ala Arg Arg Asn Asp Val Asn Ser 
    290                 295                 300                 


Thr Ser Lys Pro Ser Pro Ser Gly Gly Phe Glu Arg Arg Leu Ala Ser 
305                 310                 315                 320 


Ile Met Ala Ala Asp Thr Ala Leu His Ala Glu Val Ile Phe Asn Thr 
                325                 330                 335     


Gly Ile Tyr Glu Glu Thr Pro Thr Asp Ile Lys Glu Trp Pro Met Phe 
            340                 345                 350         


Ile Gly Met Glu Gly Thr Leu Pro Arg Leu Asn Ala Leu Gly Ser Tyr 
        355                 360                 365             


Thr Ala Arg Val Ala Gly Val Ile Gly Ala Met Val Phe Ser Pro Asn 
    370                 375                 380                 


Ser Ala Leu Tyr Leu Thr Glu Val Glu Asp Ser Gly Met Thr Glu Ala 
385                 390                 395                 400 


Lys Asp Gly Gly Pro Gly Pro Ser Phe Asn Arg Phe Tyr Gln Phe Ala 
                405                 410                 415     


Gly Pro His Leu Ala Ala Asn Pro Gln Thr Asp Arg Asp Gly His Val 
            420                 425                 430         


Leu Ser Ser Gln Ser Thr Gly Ser Ser Asn Thr Glu Phe Ser Val Asp 
        435                 440                 445             


Tyr Leu Ala Leu Ile Cys Gly Phe Gly Ala Pro Leu Leu Ala Arg Leu 
    450                 455                 460                 


Leu Phe Tyr Leu Glu Arg Cys Asp Ala Gly Ala Phe Thr Gly Gly His 
465                 470                 475                 480 


Gly Asp Ala Leu Lys Tyr Val Thr Gly Thr Phe Asp Ser Glu Ile Pro 
                485                 490                 495     


Cys Ser Leu Cys Glu Lys His Thr Arg Pro Val Cys Ala His Thr Thr 
            500                 505                 510         


Val His Arg Leu Arg Gln Arg Met Pro Arg Phe Gly Gln Ala Thr Arg 
        515                 520                 525             


Gln Pro Ile Gly Val Phe Gly Thr Met Asn Ser Gln Tyr Ser Asp Cys 
    530                 535                 540                 


Asp Pro Leu Gly Asn Tyr Ala Pro Tyr Leu Ile Leu Arg Lys Pro Gly 
545                 550                 555                 560 


Asp Gln Thr Glu Ala Ala Lys Ala Thr Met Gln Asp Thr Tyr Arg Ala 
                565                 570                 575     


Thr Leu Glu Arg Leu Phe Ile Asp Leu Glu Gln Glu Arg Leu Leu Asp 
            580                 585                 590         


Arg Gly Ala Pro Cys Ser Ser Glu Gly Leu Ser Ser Val Ile Val Asp 
        595                 600                 605             


His Pro Thr Phe Arg Arg Ile Leu Asp Thr Leu Arg Ala Arg Ile Glu 
    610                 615                 620                 


Gln Thr Thr Thr Gln Phe Met Lys Val Leu Val Glu Thr Arg Asp Tyr 
625                 630                 635                 640 


Lys Ile Arg Glu Gly Leu Ser Glu Ala Thr His Ser Met Ala Leu Thr 
                645                 650                 655     


Phe Asp Pro Tyr Ser Gly Ala Phe Cys Pro Ile Thr Asn Phe Leu Val 
            660                 665                 670         


Lys Arg Thr His Leu Ala Val Val Gln Asp Leu Ala Leu Ser Gln Cys 
        675                 680                 685             


His Cys Val Phe Tyr Gly Gln Gln Val Glu Gly Arg Asn Phe Arg Asn 
    690                 695                 700                 


Gln Phe Gln Pro Val Leu Arg Arg Arg Phe Val Asp Leu Phe Asn Gly 
705                 710                 715                 720 


Gly Phe Ile Ser Thr Arg Ser Ile Thr Val Thr Leu Ser Glu Gly Pro 
                725                 730                 735     


Val Ser Ala Pro Asn Pro Thr Leu Gly Gln Asp Ala Pro Ala Gly Arg 
            740                 745                 750         


Thr Phe Asp Gly Asp Leu Ala Arg Val Ser Val Glu Val Ile Arg Asp 
        755                 760                 765             


Ile Arg Val Lys Asn Arg Val Val Phe Ser Gly Asn Cys Thr Asn Leu 
    770                 775                 780                 


Ser Glu Ala Ala Arg Ala Arg Leu Val Gly Leu Ala Ser Ala Tyr Gln 
785                 790                 795                 800 


Arg Gln Glu Lys Arg Val Asp Met Leu His Gly Ala Leu Gly Phe Leu 
                805                 810                 815     


Leu Lys Gln Phe His Gly Leu Leu Phe Pro Arg Gly Met Pro Pro Asn 
            820                 825                 830         


Ser Lys Ser Pro Asn Pro Gln Trp Phe Trp Thr Leu Leu Gln Arg Asn 
        835                 840                 845             


Gln Met Pro Ala Asp Lys Leu Thr His Glu Glu Ile Thr Thr Ile Ala 
    850                 855                 860                 


Ala Val Lys Arg Phe Thr Glu Glu Tyr Ala Ala Ile Asn Phe Ile Asn 
865                 870                 875                 880 


Leu Pro Pro Thr Cys Ile Gly Glu Leu Ala Gln Phe Tyr Met Ala Asn 
                885                 890                 895     


Leu Ile Leu Lys Tyr Cys Asp His Ser Gln Tyr Leu Ile Asn Thr Leu 
            900                 905                 910         


Thr Ser Ile Ile Thr Gly Ala Arg Arg Pro Arg Asp Pro Ser Ser Val 
        915                 920                 925             


Leu His Trp Ile Arg Lys Asp Val Thr Ser Ala Ala Asp Ile Glu Thr 
    930                 935                 940                 


Gln Ala Lys Ala Leu Leu Glu Lys Thr Glu Asn Leu Pro Glu Leu Trp 
945                 950                 955                 960 


Thr Thr Ala Phe Thr Ser Thr His Leu Val Arg Ala Ala Met Asn Gln 
                965                 970                 975     


Arg Pro Met Val Val Leu Gly Ile Ser Ile Ser Lys Tyr His Gly Ala 
            980                 985                 990         


Ala Gly Asn Asn Arg Val Phe Gln  Ala Gly Asn Trp Ser  Gly Leu Asn 
        995                 1000                 1005             


Gly Gly  Lys Asn Val Cys Pro  Leu Phe Thr Phe Asp  Arg Thr Arg 
    1010                 1015                 1020             


Arg Phe  Ile Ile Ala Cys Pro  Arg Gly Gly Phe Ile  Cys Pro Val 
    1025                 1030                 1035             


Thr Gly  Pro Ser Ser Gly Asn  Arg Glu Thr Thr Leu  Ser Asp Gln 
    1040                 1045                 1050             


Val Arg  Gly Ile Ile Val Ser  Gly Gly Ala Met Val  Gln Leu Ala 
    1055                 1060                 1065             


Ile Tyr  Ala Thr Val Val Arg  Ala Val Gly Ala Arg  Ala Gln His 
    1070                 1075                 1080             


Met Ala  Phe Asp Asp Trp Leu  Ser Leu Thr Asp Asp  Glu Phe Leu 
    1085                 1090                 1095             


Ala Arg  Asp Leu Glu Glu Leu  His Asp Gln Ile Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Thr  Pro Trp Thr Val Glu  Gly Ala Leu Glu Ala  Val Lys Ile 
    1115                 1120                 1125             


Leu Asp  Glu Lys Thr Thr Ala  Gly Asp Gly Glu Thr  Pro Thr Asn 
    1130                 1135                 1140             


Leu Ala  Phe Asn Phe Asp Ser  Cys Glu Pro Ser His  Asp Thr Thr 
    1145                 1150                 1155             


Ser Asn  Val Leu Asn Ile Ser  Gly Ser Asn Ile Ser  Gly Ser Thr 
    1160                 1165                 1170             


Val Pro  Gly Leu Lys Arg Pro  Pro Glu Asp Asp Glu  Leu Phe Asp 
    1175                 1180                 1185             


Leu Ser  Gly Ile Pro Ile Lys  His Gly Asn Ile Thr  Met Glu Met 
    1190                 1195                 1200             


Ile 
    


<210>  11
<211>  3630
<212>  DNA
<213>  Virus ORF29

<400>  11
accaaaatgg aaaatactca gaagactgtg acagtgccca cggggcccct gggttacgtt     60

tatgcgtgcc gggttgaaga tttggatctg gaggaaattt catttttggc cgctcgtagc    120

acggactctg atttggcttt attacctttg atgcgtaatt tgaccgtgga aaaaactttt    180

acatccagcc tggcggtggt ttctggagca cgcactacgg gtcttgccgg agctggtatt    240

accttaaaac tcactaccag tcatttctat ccatctgtct ttgtctttca cggaggcaaa    300

cacgttttac ccagctccgc ggccccaaat ctcacacgcg cgtgtaacgc ggctcgagaa    360

cggtttgggt tttcacgctg ccaagggcct cctgttgacg gtgctgttga gacgaccggc    420

gctgagatat gcacccgcct tggattagag ccagaaaata caatattata cttggtggtc    480

acggcattgt ttaaggaagc cgtatttatg tgcaacgtgt ttctgcatta tggaggactc    540

gatattgttc atattaacca tggggatgtt atacgtatac cgttatttcc ggtacaactt    600

ttcatgcccg atgttaaccg tctggtaccc gacccattca acactcatca caggtctatc    660

ggagagggtt ttgtataccc aacacccttt tataacaccg ggttgtgcca tttaatacat    720

gactgtgtta ttgctcccat ggccgttgcc ttgcgcgtca gaaatgtaac tgccgtcgcc    780

cgaggagcgg cccaccttgc ttttgatgaa aatcacgagg gggcagtact cccccctgac    840

attacgtaca cgtattttca gtcctcttca agtggaacca ctaccgcccg tggagcgcgt    900

cgaaacgatg tcaactccac gtctaagcct agcccatcgg gggggtttga aagacggttg    960

gcgtctatta tggccgctga cacagccttg cacgcagaag ttatattcaa cactggaatt   1020

tacgaagaaa ctccaacaga tatcaaagaa tggccaatgt ttataggcat ggagggcact   1080

ttgccaaggc taaacgctct ggggtcatat accgctcgtg tggccggggt cattggtgcg   1140

atggttttca gcccaaattc tgcgttgtat ctaactgagg tggaggatag cgggatgacc   1200

gaagccaagg atgggggacc gggtccatca tttaatcgat tttaccagtt tgccggacct   1260

catttagctg cgaatcccca aacagatcga gatggccacg ttctatccag tcagtctacg   1320

ggttcatcaa acacagagtt tagcgtggat tatttggcac tcatttgtgg atttggagca   1380

cccctgttgg cgcgactgct tttttatcta gaacgctgtg acgctggtgc gtttacaggg   1440

ggtcacgggg atgcgttaaa atatgttacg gggacctttg actctgaaat tccatgtagt   1500

ttatgtgaaa aacacacgcg gccggtatgc gctcacacaa cagtacaccg acttagacaa   1560

cgcatgccgc gatttggaca agccacccgt caacctattg gggtgtttgg aacaatgaac   1620

agccaatata gcgactgcga tcctctagga aactatgctc catatttaat ccttcgaaaa   1680

cccggggatc aaacggaagc agcaaaggca accatgcagg acacttatag ggctacacta   1740

gaacgcttgt ttatcgatct agaacaagag cgactactgg atcgcggtgc cccatgttct   1800

tccgagggac tatcgtctgt cattgtggat catccaacgt ttcgtcgcat attagacaca   1860

ctgcgtgcgc gtatagaaca gacaacaaca caatttatga aagtgttggt tgagacccgc   1920

gattataaga tccgtgaagg attatccgaa gccacccatt caatggcgtt aacgtttgat   1980

ccatactcag gagcattttg tcccattacc aattttttag ttaaacgaac acacctagcc   2040

gtggtacaag acttagcatt aagccaatgt cattgtgtat tttacggaca gcaagttgag   2100

gggcggaact ttcgtaacca attccaacct gttttgcggc ggcgttttgt tgacctgttt   2160

aatggggggt ttatatcaac acgctctata accgtaacat tatctgaagg tcctgtatcc   2220

gccccaaatc cgacattggg acaagacgcg cccgcggggc gtacctttga tggggattta   2280

gcgcgcgtaa gcgtggaagt tattcgggat atacgagtta aaaatagggt cgttttttca   2340

ggtaactgta caaatctctc tgaggcagcc cgggcaaggc ttgtaggcct tgcaagtgcg   2400

taccaacgcc aagaaaaaag agtggatatg ttacacgggg ccctagggtt tttgcttaaa   2460

cagtttcacg gcctgttatt tcctcggggt atgccaccaa acagtaaatc ccccaacccg   2520

cagtggtttt ggaccctgtt acaacgcaac cagatgccgg cagataaact tacacacgaa   2580

gagattacca ctattgcagc tgttaaacgg tttaccgagg aatatgcagc aataaacttt   2640

attaatctac ccccaacctg cataggagaa ttagcccagt tttatatggc aaatcttatt   2700

cttaaatact gcgatcattc acagtacctt ataaatacct taacttctat aattacgggt   2760

gccaggcgcc cgcgtgaccc atcatccgtt ttgcattgga ttcgtaaaga tgtcacgtcc   2820

gccgcggaca tagaaaccca agcaaaggcg cttcttgaaa aaacggaaaa cttaccggaa   2880

ttatggacta cggcttttac ttcaactcat ttagtccgcg cggccatgaa tcaacgtccc   2940

atggtcgttt taggaataag cattagtaaa tatcacggag cggcaggaaa caaccgcgtc   3000

tttcaggcag ggaattggag cggtttaaac gggggtaaaa atgtatgccc gctatttaca   3060

tttgatcgca ctcgccgttt tataatagca tgtcctagag gaggttttat ctgccccgta   3120

acaggtccct cgtcgggaaa tcgagaaacc accctatccg accaagttcg cggtataatt   3180

gtcagtggcg gggccatggt tcaattagcc atatacgcca cggttgtgcg tgcagtgggc   3240

gctcgagcac aacatatggc atttgacgac tggttaagtc ttacagacga tgagttttta   3300

gccagagact tggaggagtt acacgaccag attatccaaa ccctggaaac gccctggacc   3360

gtagaaggcg ctctagaagc agtaaagatt ctagatgaaa aaacgacagc gggagatggg   3420

gaaaccccca caaacctagc atttaatttt gattcttgtg aaccaagcca tgacaccaca   3480

tctaacgtat taaacatttc agggtcaaac atttcagggt caactgtccc tggtcttaaa   3540

cgaccccccg aagatgacga actctttgat cttagtggta ttcccataaa acatgggaac   3600

attacaatgg aaatgattta acctccctct                                    3630


