                         SEQUENCE LISTING

<110>  Malouf, Alfred
 
<120>  COMPOSITIONS AND METHODS OF MODULATING

<130>  CWR-8827

<160>  25    

<170>  PatentIn version 3.4

<210>  1
<211>  965
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Pro Glu 
1               5                   10                  15      


Tyr Glu Ala Gln Val Lys Val Met Arg Gly Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


His Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Asp Leu Leu Leu Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Asp Lys Leu Ala Glu Arg Phe Thr Ser Arg Ser Gly Arg 
65                  70                  75                  80  


Leu Gly Gly Ser Ser Arg Glu Gln Gln Ser Phe Arg Lys Glu Pro Thr 
                85                  90                  95      


Leu Leu Ser Pro Leu His Cys Trp Ala Met Leu Leu Glu His Thr Arg 
            100                 105                 110         


Gln Gln Ser Arg Glu Ser Ala Thr Leu Ser Glu Val Leu Ala Gly Pro 
        115                 120                 125             


Leu Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Ile Val 
    130                 135                 140                 


Lys Lys Ser Lys Asp Leu Val Gln Gln Leu Gln Asp Glu Leu Leu Glu 
145                 150                 155                 160 


Val Val Ser Glu Leu Gln Thr Gln Gly Tyr Leu Ala Trp Ala Ser Leu 
                165                 170                 175     


Gln Thr Lys Lys Thr Tyr His Val Tyr His Leu Glu Ser Met Asn Ala 
            180                 185                 190         


Glu Thr Lys Leu Arg Glu Ala Glu Arg Gln Glu Glu Lys Arg Ser Gly 
        195                 200                 205             


Lys Ser Ala Leu Pro Thr Thr Thr Ala Ala Ser Ala Thr Thr Thr Ile 
    210                 215                 220                 


Thr Ile Glu Thr Glu Leu His Arg Lys Gly Ser Leu Lys Lys Gly Gly 
225                 230                 235                 240 


Arg Leu Val Glu Lys Arg Gln Ala Lys Phe Leu Glu His Lys Leu Lys 
                245                 250                 255     


Cys Thr Lys Ala Arg Asn Glu Tyr Leu Leu Ser Leu Ala Ser Val Asn 
            260                 265                 270         


Ala Ala Val Ser Asn Tyr Tyr Leu His Asp Ile Leu Asp Leu Met Asp 
        275                 280                 285             


Cys Cys Asp Thr Gly Phe His Leu Ala Leu Glu Gln Ala Leu Arg Ser 
    290                 295                 300                 


Tyr Thr Ala Ala Glu Ser Arg Thr Gln Thr Ser His Met Gln Gly Leu 
305                 310                 315                 320 


Gly Ser Leu Glu Glu Ala Leu Glu Ala Leu Asp Pro Pro Gly Asp Lys 
                325                 330                 335     


Ala Lys Val Leu Glu Val His Ala Met Ala Phe Cys Pro Pro Leu Arg 
            340                 345                 350         


Phe Asp Tyr Gln Pro His Glu Gly Asp Glu Val Ala Glu Ile Gln Val 
        355                 360                 365             


Glu Met Glu Leu Arg Asp Glu Ile Leu Pro Arg Ala Gln Asn Ile Gln 
    370                 375                 380                 


Ser Arg Leu Asp Gln Lys Thr Ile Glu Thr Glu Glu Val Asn Lys Thr 
385                 390                 395                 400 


Leu Lys Ala Thr Leu Gln Ala Leu Leu Glu Val Val Ala Ser Glu Asp 
                405                 410                 415     


Gly Asp Ile Leu Asp Ser Leu Gln Ala Ser Pro Ser Thr Glu Ser Leu 
            420                 425                 430         


Lys Ser Thr Ser Ser Asp Pro Gly Thr Arg Gln Ala Gly Arg Arg Arg 
        435                 440                 445             


Asn Gln Gln Gln Glu Thr Glu Thr Phe Tyr Ile Thr Lys Leu Gln Glu 
    450                 455                 460                 


Tyr Leu Ser Gly Arg Ser Ile Leu Ala Lys Leu Gln Ala Lys His Glu 
465                 470                 475                 480 


Lys Leu Gln Glu Ala Ile Gln Arg Gly Asn Lys Glu Glu Gln Glu Thr 
                485                 490                 495     


Ser Ser Trp Thr Gln Cys Thr Glu Arg Lys Phe His Lys Ser His His 
            500                 505                 510         


Pro Tyr Pro Gly Ser Gln Cys Thr Gln Arg Leu Phe Gly Gly Asp Leu 
        515                 520                 525             


Glu Lys Phe Ile Gln Ser Thr Gly Gln Pro Val Pro Leu Val Val Lys 
    530                 535                 540                 


Ser Cys Ile Arg Phe Ile Asn Leu Asn Gly Leu Gln His Glu Gly Ile 
545                 550                 555                 560 


Phe Ala Val Ser Gly Ala Gln Ala Arg Ile Leu Glu Ile Arg Asp Ala 
                565                 570                 575     


Phe Glu Arg Gly Glu Asp Pro Leu Val Glu Gly Cys Thr Ala His Asp 
            580                 585                 590         


Leu Asp Ser Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Ser Leu Glu 
        595                 600                 605             


Pro Pro Leu Phe Pro Leu Asp Met Phe Asn Glu Leu Leu Ala Ser Ala 
    610                 615                 620                 


Glu Leu Glu Val Val Gly Glu Arg Val Glu Leu Val Ser His Leu Leu 
625                 630                 635                 640 


Ser Arg Leu Pro Arg Pro Val Leu Val Val Leu Arg Tyr Leu Phe Thr 
                645                 650                 655     


Phe Leu Asn His Leu Ala Gln Tyr Ser Asp Glu Asn Met Met Asp Ser 
            660                 665                 670         


Tyr Asn Leu Ala Val Cys Phe Gly Pro Thr Leu Leu Pro Val Pro Ala 
        675                 680                 685             


Gly Gln Asp Pro Val Ala Leu Gln Gly Arg Val Asn Gln Leu Val Gln 
    690                 695                 700                 


Thr Leu Ile Leu Gln Pro Ala Trp Val Phe Pro Pro Thr Ala Met Leu 
705                 710                 715                 720 


Pro Gly Pro Ile Tyr Glu Lys Cys Met Ala Pro Pro Ser Ala Ser Cys 
                725                 730                 735     


Leu Gly Asp Gly Gln Leu Glu Ser Leu Ala Gly Glu Pro Glu Leu Glu 
            740                 745                 750         


Leu Lys Thr Gly Thr Lys Ala Gln Glu Asp Asp Ser Glu Gly Val Val 
        755                 760                 765             


Glu Ala Val Ala Cys Phe Ala Tyr Thr Gly Arg Thr Ala Gln Glu Leu 
    770                 775                 780                 


Thr Phe Gln Gln Gly Asp Thr Leu Arg Leu Tyr Ala Arg Ala Ser Ser 
785                 790                 795                 800 


Asp Trp Trp Arg Gly Glu His Ala Gly Val Arg Gly Leu Ile Pro His 
                805                 810                 815     


Lys Tyr Ile Thr Leu Ser Glu Gly Asp Glu Lys Gln Met Thr Gly Ser 
            820                 825                 830         


Gly Leu Gln Ala Met Gly Glu Ser Leu Ser His Pro Glu Ser Val Leu 
        835                 840                 845             


Thr Leu Glu Phe Thr Asn Arg Leu Glu Leu Gly Thr Pro Pro Glu Ala 
    850                 855                 860                 


Leu Gly Pro Ser Gly His Arg Arg His Cys Leu Val Pro Thr Ser Pro 
865                 870                 875                 880 


Glu Gln His Val Glu Met Asp Lys Ala Val Ala Gln Asn Met Asp Ser 
                885                 890                 895     


Val Phe Lys Glu Leu Leu Gly Lys Ala Ala Val Arg Gln Gly His Gly 
            900                 905                 910         


Leu Ala Ser Thr Ala Ser Pro Ser Leu Gly Thr Arg Asn Leu Lys Pro 
        915                 920                 925             


Leu Ala Cys Ser Ser Phe Ser Lys Asn Lys Val Phe Ser Arg Gly Pro 
    930                 935                 940                 


Gly Ala Pro Val Ser Pro Ser Val Ser His Pro Gln Gly Pro Asp Ser 
945                 950                 955                 960 


Thr Arg Lys Pro Val 
                965 


<210>  2
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  3
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  3

His Pro Ile Gln Ile Ala Ala Phe Leu Ala Arg Ile Pro Pro Ile Ser 
1               5                   10                  15      


Ser Ile Gly Thr Cys Ile Leu Lys 
            20                  


<210>  4
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  5
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  5
ctaggcggcc gcatggcggc gcacgggaag ttgcgg                               36


<210>  6
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  6
gctagaattc gactggcttg cgagttgaat ctgg                                 34


<210>  7
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  7
catagcggcc gcatggaacg ctttactag                                       29


<210>  8
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  8
gctagaattc gactggcttg cgagttgaat ctgg                                 34


<210>  9
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  9
ctaggcggcc gcatggcggc gcacgggaag ttgcgg                               36


<210>  10
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  10
gctagaattc agcctccaca actccctcg                                       29


<210>  11
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  11
agaaagatct atggcggcgc acggg                                           25


<210>  12
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  12
ctagaattcc gactggcttg cgagttgaat ctg                                  33


<210>  13
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  13
agaaagatct atggcggcgc acggg                                           25


<210>  14
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  14
ggacgaattc agtatgttcc agcagcat                                        28


<210>  15
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  15
ctgcaacatg aaggcatctt cgcggtatca ggtgcccagg                           40


<210>  16
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  16
acaagttggc tgaacgcttt acctgtctc                                       29


<210>  17
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  17
taaagcgttc agccaacttg tcctgtctc                                       29


<210>  18
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  18
acaaattagc ggagcgattc acctgtctc                                       29


<210>  19
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  19
tgaatcgctc cgctaatttg tcctgtctc                                       29


<210>  20
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  20
gcagaattcc tgcaggccaa gcatgaaaag ctccag                               36


<210>  21
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  21
cataagcttc tagctctcca actggccatc ccccag                               36


<210>  22
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  22
acaagttggc tgaacgcttt acctgtctc                                       29


<210>  23
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  23
taaagcgttc agccaacttg tcctgtctc                                       29


<210>  24
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  24
acaaattagc ggagcgattc acctgtctc                                       29


<210>  25
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  25
tgaatcgctc cgctaatttg tcctgtctc                                       29


