SEQUENCE LISTING

<110>  Centocor, Inc.

<120>  EGFR binding peptides and Uses Thereof

<130>  CEN5171PCT

<140>  To Be Assigned
<141>  2007-12-20

<150>  60/876,491
<151>  2006-12-21

<160>  60    

<170>  PatentIn version 3.3

<210>  1
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human EGFR extracellular domain, His-tagged

<220>
<221>  DOMAIN
<222>  (1)..(164)
<223>  Leucine-rich domain I

<220>
<221>  DOMAIN
<222>  (165)..(309)
<223>  Cysteine-rich domain II

<220>
<221>  DOMAIN
<222>  (310)..(479)
<223>  Leucine-rich domain III

<220>
<221>  DOMAIN
<222>  (480)..(621)
<223>  Cysteine-rich domain IV

<220>
<221>  METAL
<222>  (622)..(627)
<223>  Binds to zinc or other metals for purification

<400>  1



Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln 
1               5                   10                  15      
Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn 
            20                  25                  30          
Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg 
        35                  40                  45              
Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr 
    50                  55                  60                  
Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu 
65                  70                  75                  80  
Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala 
                85                  90                  95      
Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro 
            100                 105                 110         
Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn 
        115                 120                 125             
Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val 
    130                 135                 140                 
Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu 
145                 150                 155                 160 
Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp 
                165                 170                 175     
Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala 
            180                 185                 190         
Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys 
        195                 200                 205             
His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys 
    210                 215                 220                 
Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys 
225                 230                 235                 240 
Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn 
                245                 250                 255     
Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro 
            260                 265                 270         
Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly 
        275                 280                 285             
Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys 
    290                 295                 300                 
Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
305                 310                 315                 320 
Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
                325                 330                 335     
Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
            340                 345                 350         
Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
        355                 360                 365             
Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
    370                 375                 380                 
Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
385                 390                 395                 400 
Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
                405                 410                 415     
Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
            420                 425                 430         


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
        435                 440                 445             
Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
    450                 455                 460                 
Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
465                 470                 475                 480 
Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
                485                 490                 495     
Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
            500                 505                 510         
Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
        515                 520                 525             
Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
    530                 535                 540                 
Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
545                 550                 555                 560 
Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
                565                 570                 575     
Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
            580                 585                 590         
Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
        595                 600                 605             
Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser His His His 
    610                 615                 620                 
His His His 
625         


<210>  2
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human extracellular EGFR fused to human Ig constant domains

<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  Human IgG N-terminus

<220>
<221>  DOMAIN
<222>  (4)..(624)
<223>  Human EGFR extracellular domain

<220>
<221>  DOMAIN
<222>  (625)..(630)
<223>  Linker

<220>
<221>  DOMAIN
<222>  (631)..(638)
<223>  Ig "J" domain

<220>
<221>  DOMAIN
<222>  (639)..(653)
<223>  Ig hinge

<220>
<221>  DOMAIN
<222>  (654)..(870)
<223>  Ig CH2 and CH3

<400>  2

Gln Ile Gln Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys 
1               5                   10                  15      
Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg 
            20                  25                  30          
Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr 
        35                  40                  45              
Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val 
    50                  55                  60                  
Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu 
65                  70                  75                  80  
Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr 
                85                  90                  95      
Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys 
            100                 105                 110         
Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg 
        115                 120                 125             
Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg 
    130                 135                 140                 
Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln 
145                 150                 155                 160 
Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly 
                165                 170                 175     
Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile 
            180                 185                 190         
Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser 
        195                 200                 205             
Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu 
    210                 215                 220                 
Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys 
225                 230                 235                 240 
Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met 
                245                 250                 255     
Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys 
            260                 265                 270         
Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
        275                 280                 285             
Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
    290                 295                 300                 
Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly 
305                 310                 315                 320 
Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
                325                 330                 335     
His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro 
            340                 345                 350         


Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro 
        355                 360                 365             
Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu 
    370                 375                 380                 
Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu 
385                 390                 395                 400 
Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser 
                405                 410                 415     
Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu 
            420                 425                 430         
Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu 
        435                 440                 445             
Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly 
    450                 455                 460                 
Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala 
465                 470                 475                 480 
Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly 
                485                 490                 495     
Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg 
            500                 505                 510         
Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe 
        515                 520                 525             
Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln 
    530                 535                 540                 
Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln 
545                 550                 555                 560 
Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala 
                565                 570                 575     
Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala 
            580                 585                 590         
Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr 
        595                 600                 605             
Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
    610                 615                 620                 
Arg Ser Gly Gly Gly Ser Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
625                 630                 635                 640 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                645                 650                 655     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            660                 665                 670         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        675                 680                 685             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    690                 695                 700                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
705                 710                 715                 720 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                725                 730                 735     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            740                 745                 750         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        755                 760                 765             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    770                 775                 780                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
785                 790                 795                 800 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                805                 810                 815     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            820                 825                 830         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        835                 840                 845             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    850                 855                 860                 
Ser Leu Ser Pro Gly Lys 
865                 870 


<210>  3
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable domain truncated human IgG1 antibody

<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Human IgG1 Variable N-terminal residues

<220>
<221>  MISC_FEATURE
<222>  (4)..(13)
<223>  Human IgG variable J-derived sequences

<220>
<221>  MISC_FEATURE
<222>  (14)..(28)
<223>  Human IgG hinge region

<220>
<221>  MISC_FEATURE
<222>  (29)..(202)
<223>  Human IgG1 constant regions (C2 and C3)

<400>  3

Gln Ile Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Glu Pro Lys 
1               5                   10                  15      
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 
Leu Ser Pro Gly Lys 
                245 


<210>  4
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  4
aagtatacag gcccagatcc agctggagga aaagaaagtt tgc                       43

<210>  5
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  5
aaagatctgg acgggatctt aggccca                                         27

<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  6

Val Leu Cys Ser Asn Phe Tyr His Pro Leu Cys His Ser 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random Peptide

<400>  7

Val Leu Cys His Arg Tyr Tyr His Pro Ile Cys Tyr Thr 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  8

Thr Leu Cys Arg Ser Phe Phe His Pro Leu Cys Tyr Ala 
1               5                   10              


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide


<220>
<221>  Mutagen
<222>  (3)..(4)
<223>  may be any naturally occurring amino acid

<220>
<221>  Mutagen
<222>  (5)..(6)
<223>  aa are independently, F or Y

<400>  9

Leu Cys Xaa Xaa Xaa Xaa His Pro Leu Cys 
1               5                   10  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  10

Tyr Arg Leu Phe Val Asp Glu Ser Ile Phe Phe Cys Thr Arg Leu 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  11

Glu Leu Gly Leu Pro Thr Leu Leu Cys Trp Pro Thr Asp Thr Leu 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  12

Val Ser Gly Ile Leu Pro Ile Leu Val Cys His Pro Ala Ala Thr 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  13

Leu Pro Asp Asp Ser Leu Pro Glu Leu Ile Cys Lys Val Arg Gly 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  14

His Val Ser Leu Gln Ser Leu Pro Glu Leu Ile Cys Val Val Ser 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  15

Asn Trp Phe Ser Leu Pro Thr Leu Leu Cys Phe Pro Leu Asn Pro 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  16

Ser Thr Ile Thr Ser Leu Pro Thr Leu Gln Cys Trp Pro Ile Leu 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  17

Pro Ile Asp Asp Glu Ser Leu Pro Val Leu Tyr Cys Val Thr Ser 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  18

Pro Ile Phe Ser Ser Leu Pro Val Leu Tyr Cys Thr Ser Gln Leu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  19

Gly Ala Asp Thr Leu Pro Asp Leu Leu Cys Trp Glu Ser Ser Leu 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  20

Thr Val Phe Thr Leu Pro Glu Leu Val Cys Val Val Ala Gly Thr 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  21

Leu Pro Asp Leu Ile Cys Ala Val Asp Ser Gly Thr Ser Gly Ala 
1               5                   10                  15  


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide


<220>
<221>  MUTAGEN
<222>  (4)..(4)
<223>  may be any natural aa

<400>  22

Ser Leu Pro Xaa Leu Leu Cys 
1               5           


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  23

Ala Gly Cys Ile Ala Phe Val Asp Val Val Tyr Cys Ala Arg 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  24

Ala Lys Cys Ile Ala Phe Gly Asn Ser Val Tyr Cys Leu Asn 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  25

Arg Asp Cys Ile Ile Phe Asp Lys Thr Val Tyr Cys Val Ile 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  26

Lys His Cys Ile Leu Phe Glu Lys Thr Val Tyr Cys Ala Lys 
1               5                   10                  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  27

Asp Ser Cys Ile Gln Phe Ala Asn Leu Leu Tyr Cys Ala Ile 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  28

Thr Asp Cys Ile Arg Phe Gly Val Leu Trp Tyr Cys Leu Val 
1               5                   10                  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  29

Arg Ala Cys Ile Thr Phe Gly Lys Val Val Tyr Cys Glu Val 
1               5                   10                  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  30

Ala Tyr Cys Ser Phe Val Ala Gly Asp Leu Val Cys Gln Val 
1               5                   10                  


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  31

Thr Asp Cys Val Ile Phe Gly Leu Glu Thr Tyr Cys Leu Arg 
1               5                   10                  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  32

Ser Asp Cys Val Leu Phe Gly Ser Lys Leu Phe Cys Ser Ala 
1               5                   10                  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  33

Thr Asp Cys Val Arg Phe Gly Glu Thr Ile Tyr Cys Ile Val 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  34

Tyr Asp Cys Val Ser Phe Gly Ala Val Ala Tyr Cys Pro Gln 
1               5                   10                  


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  35

Arg Gly Cys Val Val Phe Gly Asp Asn Ile Tyr Cys Ile Val 
1               5                   10                  


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of several selected peptides


<220>
<221>  Mutagen
<222>  (3)..(3)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (4)..(4)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (7)..(7)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (8)..(8)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (9)..(9)
<223>  X may be any natural amino acid

<400>  36

Asp Cys Xaa Xaa Phe Gly Xaa Xaa Xaa Tyr Cys 
1               5                   10      


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  37

Met Ile Cys Tyr Leu Val Asp Ser Gly Asn Ile Ile Cys Tyr Lys 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  38

Tyr Asp Cys Met Ile Arg Ala Asp Gly Ser Leu Ile Cys Trp Cys 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  39

Gly Pro Cys Val Leu Ile Arg Asp Tyr Tyr Leu Leu Cys Leu Glu 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  40


Ala Phe Cys Arg Leu Asp Phe Asn Gln Trp Leu Thr Cys Leu Val 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  41

Cys Asp Cys Arg Glu Ala Val Ser Ala Ser Leu Val Cys Arg Tyr 
1               5                   10                  15  


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of several selected peptides


<220>
<221>  Mutagen
<222>  (2)..(2)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (4)..(4)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (5)..(5)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (7)..(7)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (8)..(8)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (9)..(9)
<223>  X may be any natural amino acid

<220>
<221>  Mutagen
<222>  (10)..(10)
<223>  X may be any natural amino acid

<400>  42

Cys Xaa Leu Xaa Xaa Asp Xaa Xaa Xaa Xaa Cys 
1               5                   10      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  43

Pro Thr Cys Asp Ser Ala Thr Arg Arg Val Leu Thr Ile Cys Ala Asp 
1               5                   10                  15      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  44

Trp Met Cys Phe Leu Glu Gly Tyr Gly Ala Ser Leu Met Cys Gln Cys 
1               5                   10                  15      


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  45

Asp Ser Cys Cys Ser Phe Leu Thr Asp Gly Thr Val Val Cys Ser Leu 
1               5                   10                  15      


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  46

Tyr Ile Cys Thr Pro Ser Asp Ile Asp Ser Trp Tyr Ile Cys Tyr Leu 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  47

Ser Val Cys Val Gly Thr Ala Phe Pro Gly Trp Met Val Cys Gly Pro 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  48

Lys Thr Cys Val Ser Thr Thr Phe Asp Leu Trp Phe Val Cys Phe Ala 
1               5                   10                  15      


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  49

Leu Leu Cys Ala Thr Thr Ser Phe Arg Asp Trp Phe Val Cys Phe Thr 
1               5                   10                  15      


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of several selected peptides


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Xaa Xaa Cys Xaa Xaa Thr Xaa Phe Asp Xaa Trp Xaa Val Cys Xaa Xaa 
1               5                   10                  15      


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  51

Ser Gly Cys Leu Asp Ala Leu Trp Gln Cys Val Tyr 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  52

Asp Ala Cys Thr Met Val Phe Leu Trp Cys Ser Leu 
1               5                   10          


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  53

Arg Trp Cys Tyr Phe Trp Trp Ile Thr Ile Cys Glu Leu 
1               5                   10              


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  54

Met Phe Cys Phe Arg Trp Tyr Ala Gly Trp Ser Cys Val Ser 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  55

Asp Pro Cys Thr Trp Glu Val Trp Gly Arg Glu Cys Leu Gln 
1               5                   10                  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  56

His Phe Tyr Pro Thr Lys Thr Pro Gly Tyr 
1               5                   10  


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  57

Ala Ala Ser Arg Ala Leu Trp Ala Phe Asn Ser Asp 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  58

Ser Tyr Tyr Trp Gly Tyr Thr Val Asp Ile Arg Arg 
1               5                   10          


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random peptide

<400>  59

Ser Glu Cys Phe Pro Leu Ala Pro Asp Trp Leu Ser Cys Ile Leu 
1               5                   10                  15  


<210>  60
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fused to human IgG4 derived constant domains.


<220>
<221>  DOMAIN
<222>  (1)..(2)
<223>  Phage display remnant

<220>
<221>  PEPTIDE
<222>  (3)..(16)
<223>  P190, identified EGFR-binding peptide

<220>
<221>  FLEX
<222>  (17)..(20)
<223>  Flexible linker basic unit which repeated 1, 2 or 4 times in 
       constructs exemplified

<220>
<221>  FLEX
<222>  (17)..(20)
<223>  Flexible linker basic unit which is lengthened in constructs 
       exemplified

<220>
<221>  DOMAIN
<222>  (21)..(242)
<223>  hIgG4 derived Fc domain

<400>  60

Gly Gly Asp Pro Cys Thr Trp Glu Val Trp Gly Arg Glu Cys Leu Gln 
1               5                   10                  15      
Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            20                  25                  30          
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    50                  55                  60                  
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        115                 120                 125             
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
        195                 200                 205             
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
225                 230                 235                 240 
Gly Lys 

CEN5171PCT

	 24 

