                              Sequence Listing

<110> Genentech, Inc.
      Ferrara, Napoleone

<120> TRANSGENIC MICE EXPRESSING HUMANIZED VEGF

<130> P2448R1 WO


<150> US 60/871,736
<151> 2006-12-22

<160> 12

<210> 1
<211> 190
<212> PRT
<213> Mus musculus

<400> 1
 Met Asn Phe Leu Leu Ser Trp Val His Trp Thr Leu Ala Leu Leu
   1               5                  10                  15

 Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Thr Thr
                  20                  25                  30

 Glu Gly Glu Gln Lys Ser His Glu Val Ile Lys Phe Met Asp Val
                  35                  40                  45

 Tyr Gln Arg Ser Tyr Cys Arg Pro Ile Glu Thr Leu Val Asp Ile
                  50                  55                  60

 Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser
                  65                  70                  75

 Cys Val Pro Leu Met Arg Cys Ala Gly Cys Cys Asn Asp Glu Ala
                  80                  85                  90

 Leu Glu Cys Val Pro Thr Ser Glu Ser Asn Ile Thr Met Gln Ile
                  95                 100                 105

 Met Arg Ile Lys Pro His Gln Ser Gln His Ile Gly Glu Met Ser
                 110                 115                 120

 Phe Leu Gln His Ser Arg Cys Glu Cys Arg Pro Lys Lys Asp Arg
                 125                 130                 135

 Thr Lys Pro Glu Asn His Cys Glu Pro Cys Ser Glu Arg Arg Lys
                 140                 145                 150

 His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys
                 155                 160                 165

 Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu
                 170                 175                 180

 Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg
                 185                 190

<210> 2
<211> 191
<212> PRT
<213> Homo sapiens

<400> 2
 Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu
   1               5                  10                  15

 Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala
                  20                  25                  30

 Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp
                  35                  40                  45

 Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp
                  50                  55                  60

 Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro
                  65                  70                  75

 Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu
                  80                  85                  90

 Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln
                  95                 100                 105

 Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met
                 110                 115                 120

 Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp
                 125                 130                 135

 Arg Ala Arg Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg
                 140                 145                 150

 Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys
                 155                 160                 165

 Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn
                 170                 175                 180

 Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg
                 185                 190    

<210> 3
<211> 6
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> CAAT_signal modified_base
<222> 2
<223> n at position 2 may be A, G, C or T

<400> 3
 cncaat 6

<210> 4
<211> 6
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<220>
<221> polyA_signal
<222> full
<223> polyadenylation signal

<400> 4
 aataaa 6

<210> 5
<211> 29
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 5
 agcgaagcta ctgccatccg  attgagacc 29

<210> 6
<211> 38
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 6
 tgatgcgctg tggaggctgc tgtaacgatg  aaggcctg 38

<210> 7
<211> 49
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 7
 tgtaacgatg aaggcctgga gtgcgtgcgt gcccacggaa  gagagcaac 49

<210> 8
<211> 36
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 8
 atcaaacctc accaaggcca gcacatagga  gagatg 36

<210> 9
<211> 37
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 9
 tgagcttcct acagcacaac aaatgtgaat  gcaggtg 37

<210> 10
<211> 43
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 10
 tgcagaccaa agaaagacag agcacggcaa gaaaagtaag  tgg 43

<210> 11
<211> 190
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 11
 Met Asn Phe Leu Leu Ser Trp Val His Trp Thr Leu Ala Leu Leu
   1               5                  10                  15

 Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Thr Thr
                  20                  25                  30

 Glu Gly Glu Gln Lys Ser His Glu Val Ile Lys Phe Met Asp Val
                  35                  40                  45

 Tyr Gln Arg Ser Tyr Cys Arg Pro Ile Glu Thr Leu Val Asp Ile
                  50                  55                  60

 Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser
                  65                  70                  75

 Cys Val Pro Leu Met Arg Cys Ala Gly Cys Cys Asn Asp Glu Ala
                  80                  85                  90

 Leu Glu Cys Val Pro Thr Ser Glu Ser Asn Ile Thr Met Gln Ile
                  95                 100                 105

 Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser
                 110                 115                 120

 Phe Leu Gln His Ser Arg Cys Glu Cys Arg Pro Lys Lys Asp Arg
                 125                 130                 135

 Thr Lys Pro Glu Asn His Cys Glu Pro Cys Ser Glu Arg Arg Lys
                 140                 145                 150

 His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys
                 155                 160                 165

 Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu
                 170                 175                 180

 Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg
                 185                 190

<210> 12
<211> 190
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 12
 Met Asn Phe Leu Leu Ser Trp Val His Trp Thr Leu Ala Leu Leu
   1               5                  10                  15

 Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Thr Thr
                  20                  25                  30

 Glu Gly Glu Gln Lys Ser His Glu Val Ile Lys Phe Met Asp Val
                  35                  40                  45

 Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile
                  50                  55                  60

 Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser
                  65                  70                  75

 Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly
                  80                  85                  90

 Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
                  95                 100                 105

 Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser
                 110                 115                 120

 Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg
                 125                 130                 135

 Ala Arg Gln Glu Asn His Cys Glu Pro Cys Ser Glu Arg Arg Lys
                 140                 145                 150

 His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys
                 155                 160                 165

 Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu
                 170                 175                 180

 Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg
                 185                 190

