                         SEQUENCE LISTING

<110>  University of Rochester
       Rose, Robert
       Malboeuf, Christine
       Lee, Young-Eun Ellen
 
<120>  COMBINED HUMAN PAPILLOMAVIRUS VLP/GENE DELIVERY SYSTEM AND USE 
       THEREOF AS A VACCINE FOR PROPHYLAXIS AND IMMUNOTHERAPY OF 
       INFECTIOUS DISEASES AND TUMORS

<130>  176/62171

<150>  60/824,010
<151>  2006-08-30

<160>  13    

<170>  PatentIn version 3.3

<210>  1
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  HIV NefV3 Epitope

<400>  1

Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys 
1               5                   10                  15  


<210>  2
<211>  435
<212>  PRT
<213>  Artificial

<220>
<223>  L2N-Nef-V3

<400>  2

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro 
        115                 120                 125             


Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala 
    130                 135                 140                 


Ile Leu Asp Ile Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn 
145                 150                 155                 160 


Pro Thr Phe Thr Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu 
                165                 170                 175     


Thr Gly Gly His Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn 
            180                 185                 190         


Tyr Glu Glu Ile Pro Met Asp Thr Phe Ile Val Ser Thr Asn Pro Asn 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Pro Ile Pro Gly Ser Arg Pro Val Ala Arg 
    210                 215                 220                 


Leu Met Arg Arg Ala Glu Pro Ala Ala Glu Gly Val Gly Ala Val Ser 
225                 230                 235                 240 


Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala 
                245                 250                 255     


Thr Asn Ala Ala Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val 
            260                 265                 270         


Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg Pro Met Thr Tyr Lys 
        275                 280                 285             


Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu 
    290                 295                 300                 


Gly Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val 
305                 310                 315                 320 


Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly 
                325                 330                 335     


Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val 
            340                 345                 350         


Pro Val Glu Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn 
        355                 360                 365             


Cys Leu Leu His Pro Met Ser Gln His Gly Met Asp Asp Pro Glu Lys 
    370                 375                 380                 


Glu Val Leu Val Trp Lys Phe Asp Ser Lys Leu Ala Phe His His Met 
385                 390                 395                 400 


Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Ile Gln Arg 
                405                 410                 415     


Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys Asp Tyr Lys Asp Asp 
            420                 425                 430         


Asp Asp Lys 
        435 


<210>  3
<211>  1308
<212>  DNA
<213>  Artificial

<220>
<223>  L2N-Nef-V3

<400>  3
atgcgacaca aacgttctgc aaaacgcaca aaacgtgcat cggctaccca actttataaa     60

acatgcaaac aggcaggtac atgtccacct gacattatac ctaaggttga aggcaaaact    120

attgctgaac aaatattaca atatggaagt atgggtgtat tttttggtgg gttaggaatt    180

ggaacagggt cgggtacagg cggacgcact gggtatattc cattgggaac aaggcctccc    240

acagctacag atacacttgc tcctgtaaga ccccctttaa cagtagatcc tgtgggccct    300

tctgatcctt ctatagtttc tttagtggaa gaaactagtt ttattgatgc tggtgcacca    360

acatctgtac cttccattcc cccagatgta tcaggattta gtattactac ttcaactgat    420

accacacctg ctatattaga tattaataat actgttacta ctgttactac acataataat    480

cccactttca ctgacccatc tgtattgcag cctccaacac ctgcagaaac tggagggcat    540

tttacacttt catcatccac tattagtaca cataattatg aagaaattcc tatggataca    600

tttattgtta gcacaaaccc taacacagta actagtagca cacccatacc agggtctcgc    660

ccagtggcac gcctaatgag gcgagctgag ccagcagcag agggagtggg agcagtatct    720

cgagacctgg aaaaacatgg agcaattaca agtagcaata cagcagctac caatgctgct    780

tgtgcctggc tagaagcaca agaggaggaa gaagtgggtt ttccagtcag acctcaggta    840

cctttaagac caatgactta caaggcagca gtagatctta gccacttttt aaaagaaaag    900

gggggactgg aagggttaat ttactcccaa aaaagacaag atatccttga tctgtgggtc    960

taccacacac aaggctactt ccctgattgg cagaactaca caccagggcc aggaatcaga   1020

tatccactga cctttgggtg gtgcttcaaa ctagtaccag ttgagccaga gaaggtagaa   1080

gaggccaatg aaggagagaa caactgcttg ctacacccta tgagccagca tgggatggat   1140

gacccagaga aagaagtatt agtgtggaag tttgacagca aactagcatt tcatcacatg   1200

gcccgagagc tgcatccgga gtactacaaa gactgccgaa tccaacgcgg accaggtcga   1260

gcatttgtaa caattggaaa agactacaag gacgacgatg acaagtag                1308


<210>  4
<211>  683
<212>  PRT
<213>  Artificial

<220>
<223>  L2(full)-Nef-V3

<400>  4

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro 
        115                 120                 125             


Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala 
    130                 135                 140                 


Ile Leu Asp Ile Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn 
145                 150                 155                 160 


Pro Thr Phe Thr Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu 
                165                 170                 175     


Thr Gly Gly His Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn 
            180                 185                 190         


Tyr Glu Glu Ile Pro Met Asp Thr Phe Ile Val Ser Thr Asn Pro Asn 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Pro Ile Pro Gly Ser Arg Pro Val Ala Arg 
    210                 215                 220                 


Leu Gly Leu Tyr Ser Arg Thr Thr Gln Gln Val Lys Val Val Asp Pro 
225                 230                 235                 240 


Ala Phe Val Thr Thr Pro Thr Lys Leu Ile Thr Tyr Asp Asn Pro Ala 
                245                 250                 255     


Tyr Glu Gly Ile Asp Val Asp Asn Thr Leu Tyr Phe Ser Ser Asn Asp 
            260                 265                 270         


Asn Ser Ile Asn Ile Ala Pro Asp Pro Asp Phe Leu Asp Ile Val Ala 
        275                 280                 285             


Leu His Arg Pro Ala Leu Thr Ser Arg Arg Thr Gly Ile Arg Tyr Ser 
    290                 295                 300                 


Arg Ile Gly Asn Lys Gln Thr Leu Arg Thr Arg Ser Gly Lys Ser Ile 
305                 310                 315                 320 


Gly Ala Lys Val His Tyr Tyr Tyr Asp Leu Ser Thr Ile Asp Pro Ala 
                325                 330                 335     


Glu Glu Ile Glu Leu Gln Thr Ile Thr Pro Ser Thr Tyr Thr Thr Thr 
            340                 345                 350         


Ser His Ala Ala Ser Pro Thr Ser Ile Asn Asn Gly Leu Tyr Asp Ile 
        355                 360                 365             


Tyr Ala Asp Asp Phe Ile Thr Asp Thr Ser Thr Thr Pro Val Pro Ser 
    370                 375                 380                 


Val Pro Ser Thr Ser Leu Ser Gly Tyr Ile Pro Ala Asn Thr Thr Ile 
385                 390                 395                 400 


Pro Phe Gly Gly Ala Tyr Asn Ile Pro Leu Val Ser Gly Pro Asp Ile 
                405                 410                 415     


Pro Ile Asn Ile Thr Asp Gln Ala Pro Ser Leu Ile Pro Ile Val Pro 
            420                 425                 430         


Gly Ser Pro Gln Tyr Thr Ile Ile Ala Asp Ala Gly Asp Phe Tyr Leu 
        435                 440                 445             


His Pro Ser Tyr Tyr Met Leu Arg Lys Arg Arg Lys Arg Leu Pro Tyr 
    450                 455                 460                 


Phe Phe Ser Asp Val Ser Leu Ala Ala Met Arg Arg Ala Glu Pro Ala 
465                 470                 475                 480 


Ala Glu Gly Val Gly Ala Val Ser Arg Asp Leu Glu Lys His Gly Ala 
                485                 490                 495     


Ile Thr Ser Ser Asn Thr Ala Ala Thr Asn Ala Ala Cys Ala Trp Leu 
            500                 505                 510         


Glu Ala Gln Glu Glu Glu Glu Val Gly Phe Pro Val Arg Pro Gln Val 
        515                 520                 525             


Pro Leu Arg Pro Met Thr Tyr Lys Ala Ala Val Asp Leu Ser His Phe 
    530                 535                 540                 


Leu Lys Glu Lys Gly Gly Leu Glu Gly Leu Ile Tyr Ser Gln Lys Arg 
545                 550                 555                 560 


Gln Asp Ile Leu Asp Leu Trp Val Tyr His Thr Gln Gly Tyr Phe Pro 
                565                 570                 575     


Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr 
            580                 585                 590         


Phe Gly Trp Cys Phe Lys Leu Val Pro Val Glu Pro Glu Lys Val Glu 
        595                 600                 605             


Glu Ala Asn Glu Gly Glu Asn Asn Cys Leu Leu His Pro Met Ser Gln 
    610                 615                 620                 


His Gly Met Asp Asp Pro Glu Lys Glu Val Leu Val Trp Lys Phe Asp 
625                 630                 635                 640 


Ser Lys Leu Ala Phe His His Met Ala Arg Glu Leu His Pro Glu Tyr 
                645                 650                 655     


Tyr Lys Asp Cys Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr 
            660                 665                 670         


Ile Gly Lys Asp Tyr Lys Asp Asp Asp Asp Lys 
        675                 680             


<210>  5
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  L2(full)-Nef-V3

<400>  5
atgcgacaca aacgttctgc aaaacgcaca aaacgtgcat cggctaccca actttataaa     60

acatgcaaac aggcaggtac atgtccacct gacattatac ctaaggttga aggcaaaact    120

attgctgaac aaatattaca atatggaagt atgggtgtat tttttggtgg gttaggaatt    180

ggaacagggt cgggtacagg cggacgcact gggtatattc cattgggaac aaggcctccc    240

acagctacag atacacttgc tcctgtaaga ccccctttaa cagtagatcc tgtgggccct    300

tctgatcctt ctatagtttc tttagtggaa gaaactagtt ttattgatgc tggtgcacca    360

acatctgtac cttccattcc cccagatgta tcaggattta gtattactac ttcaactgat    420

accacacctg ctatattaga tattaataat actgttacta ctgttactac acataataat    480

cccactttca ctgacccatc tgtattgcag cctccaacac ctgcagaaac tggagggcat    540

tttacacttt catcatccac tattagtaca cataattatg aagaaattcc tatggataca    600

tttattgtta gcacaaaccc taacacagta actagtagca cacccatacc agggtctcgc    660

ccagtggcac gcctaggatt atatagtcgc acaacacaac aggttaaagt tgtagaccct    720

gcttttgtaa ccactcccac taaacttatt acatatgata atcctgcata tgaaggtata    780

gatgtggata atacattata tttttctagt aatgataata gtattaatat agctccagat    840

cctgactttt tggatatagt tgctttacat aggccagcat taacctctag gcgtactggc    900

attaggtaca gtagaattgg taataaacaa acactacgta ctcgtagtgg aaaatctata    960

ggtgctaagg tacattatta ttatgattta agtactattg atcctgcaga agaaatagaa   1020

ttacaaacta taacaccttc tacatatact accacttcac atgcagcctc acctacttct   1080

attaataatg gattatatga tatttatgca gatgacttta ttacagatac ttctacaacc   1140

ccggtaccat ctgtaccctc tacatcttta tcaggttata ttcctgcaaa tacaacaatt   1200

ccttttggtg gtgcatacaa tattccttta gtatcaggtc ctgatatacc cattaatata   1260

actgaccaag ctccttcatt aattcctata gttccagggt ctccacaata tacaattatt   1320

gctgatgcag gtgactttta tttacatcct agttattaca tgttacgaaa acgacgtaaa   1380

cgtttaccat attttttttc agatgtctct ttggctgcca tgaggcgagc tgagccagca   1440

gcagagggag tgggagcagt atctcgagac ctggaaaaac atggagcaat tacaagtagc   1500

aatacagcag ctaccaatgc tgcttgtgcc tggctagaag cacaagagga ggaagaagtg   1560

ggttttccag tcagacctca ggtaccttta agaccaatga cttacaaggc agcagtagat   1620

cttagccact ttttaaaaga aaagggggga ctggaagggt taatttactc ccaaaaaaga   1680

caagatatcc ttgatctgtg ggtctaccac acacaaggct acttccctga ttggcagaac   1740

tacacaccag ggccaggaat cagatatcca ctgacctttg ggtggtgctt caaactagta   1800

ccagttgagc cagagaaggt agaagaggcc aatgaaggag agaacaactg cttgctacac   1860

cctatgagcc agcatgggat ggatgaccca gagaaagaag tattagtgtg gaagtttgac   1920

agcaaactag catttcatca catggcccga gagctgcatc cggagtacta caaagactgc   1980

cgaatccaac gcggaccagg tcgagcattt gtaacaattg gaaaagacta caaggacgac   2040

gatgacaagt ag                                                       2052


<210>  6
<211>  628
<212>  PRT
<213>  Artificial

<220>
<223>  CRT-Nef-V3-Flag

<400>  6

Met Leu Leu Pro Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Ala 
1               5                   10                  15      


Ala Glu Pro Val Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Glu Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Gln Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Arg 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Pro Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Ala Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Ala Asn 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Thr 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Glu Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Glu 
    370                 375                 380                 


Asp Glu Glu Asp Lys Asp Asp Lys Glu Asp Glu Asp Glu Asp Glu Glu 
385                 390                 395                 400 


Asp Lys Asp Glu Glu Glu Glu Glu Ala Ala Ala Gly Gln Ala Lys Asp 
                405                 410                 415     


Glu Leu Met Arg Arg Ala Glu Pro Ala Ala Glu Gly Val Gly Ala Val 
            420                 425                 430         


Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala 
        435                 440                 445             


Ala Thr Asn Ala Ala Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu 
    450                 455                 460                 


Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg Pro Met Thr Tyr 
465                 470                 475                 480 


Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu 
                485                 490                 495     


Glu Gly Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp 
            500                 505                 510         


Val Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro 
        515                 520                 525             


Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu 
    530                 535                 540                 


Val Pro Val Glu Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn 
545                 550                 555                 560 


Asn Cys Leu Leu His Pro Met Ser Gln His Gly Met Asp Asp Pro Glu 
                565                 570                 575     


Lys Glu Val Leu Val Trp Lys Phe Asp Ser Lys Leu Ala Phe His His 
            580                 585                 590         


Met Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Ile Gln 
        595                 600                 605             


Arg Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys Asp Tyr Lys Asp 
    610                 615                 620                 


Asp Asp Asp Lys 
625             


<210>  7
<211>  1887
<212>  DNA
<213>  Artificial

<220>
<223>  CRT-Nef-V3-Flag

<400>  7
atgctgctcc ctgtgccgct gctgctcggc ctgctcggcc tggccgccgc cgagcccgtc     60

gtctacttca aggagcagtt tctggacgga gatgggtgga ccgagcgctg gatcgaatcc    120

aaacacaagt ccgattttgg caaattcgtc ctcagttcgg gcaagttcta cggcgatcag    180

gagaaagata aagggctgca gaccagccag gacgcccgct tctacgccct gtcggcccga    240

ttcgagccgt tcagcaacaa gggccagcca ctggtggtgc agttcaccgt gaaacacgag    300

cagaacattg actgcggggg cggctacgtg aagctgtttc cggccggcct ggaccagaag    360

gacatgcacg gggactctga gtacaacatc atgtttggtc ctgacatctg tggccccggc    420

accaagaagg ttcacgtcat cttcaactac aagggcaaga acgtgctgat caacaaggac    480

atccgttgca aggacgacga gttcacacac ctgtacacgc tgatcgtgcg gccggacaac    540

acgtatgagg tgaagattga caacagccag gtggagtcgg gctccctgga ggatgactgg    600

gacttcctac cccccaagaa gataaaggac ccagatgcct cgaagcctga agactgggac    660

gagcgggcca agatcgacga ccccacggac tccaagcccg aggactggga caagcccgag    720

cacatccccg acccggacgc gaagaagccc gaagactggg acgaagaaat ggacggagag    780

tgggagccgc cggtgattca gaaccccgag tacaagggtg agtggaagcc gcggcagatc    840

gacaaccccg attacaaagg cacctggatc caccccgaaa tcgacaaccc cgagtactcg    900

cccgacgcta acatctatgc ctacgacagc tttgccgtgc tgggcttgga cctctggcag    960

gtcaagtcgg gcaccatctt cgacaacttc ctcatcacca acgatgaggc gtacgcagag   1020

gagtttggca acgagacgtg gggcgtcacc aagacggccg agaagcagat gaaagacaag   1080

caggacgagg agcagcggct gaaggaggag gaggaggaga agaagcggaa ggaggaggag   1140

gaggccgagg aggacgagga ggacaaggac gacaaggagg acgaggatga ggacgaggag   1200

gacaaggacg aggaggagga ggaggcggcc gccggccagg ccaaggacga gctgatgagg   1260

cgagctgagc cagcagcaga gggagtggga gcagtatctc gagacctgga aaaacatgga   1320

gcaattacaa gtagcaatac agcagctacc aatgctgctt gtgcctggct agaagcacaa   1380

gaggaggaag aagtgggttt tccagtcaga cctcaggtac ctttaagacc aatgacttac   1440

aaggcagcag tagatcttag ccacttttta aaagaaaagg ggggactgga agggttaatt   1500

tactcccaaa aaagacaaga tatccttgat ctgtgggtct accacacaca aggctacttc   1560

cctgattggc agaactacac accagggcca ggaatcagat atccactgac ctttgggtgg   1620

tgcttcaaac tagtaccagt tgagccagag aaggtagaag aggccaatga aggagagaac   1680

aactgcttgc tacaccctat gagccagcat gggatggatg acccagagaa agaagtatta   1740

gtgtggaagt ttgacagcaa actagcattt catcacatgg cccgagagct gcatccggag   1800

tactacaaag actgccgaat ccaacgcgga ccaggtcgag catttgtaac aattggaaaa   1860

gactacaagg acgacgatga caagtag                                       1887


<210>  8
<211>  383
<212>  PRT
<213>  artificial

<220>
<223>  L2N-E6

<400>  8

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro 
        115                 120                 125             


Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala 
    130                 135                 140                 


Ile Leu Asp Ile Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn 
145                 150                 155                 160 


Pro Thr Phe Thr Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu 
                165                 170                 175     


Thr Gly Gly His Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn 
            180                 185                 190         


Tyr Glu Glu Ile Pro Met Asp Thr Phe Ile Val Ser Thr Asn Pro Asn 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Pro Ile Pro Gly Ser Arg Pro Val Ala Arg 
    210                 215                 220                 


Leu Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg 
225                 230                 235                 240 


Pro Arg Lys Leu Pro His Leu Cys Thr Glu Leu Gln Thr Thr Ile His 
                245                 250                 255     


Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg 
            260                 265                 270         


Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp 
        275                 280                 285             


Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys 
    290                 295                 300                 


Ile Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile 
                325                 330                 335     


Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp 
            340                 345                 350         


Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys 
        355                 360                 365             


Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
    370                 375                 380             


<210>  9
<211>  1152
<212>  DNA
<213>  artificial

<220>
<223>  L2N-E6

<400>  9
atgcgacaca aacgttctgc aaaacgcaca aaacgtgcat cggctaccca actttataaa     60

acatgcaaac aggcaggtac atgtccacct gacattatac ctaaggttga aggcaaaact    120

attgctgaac aaatattaca atatggaagt atgggtgtat tttttggtgg gttaggaatt    180

ggaacagggt cgggtacagg cggacgcact gggtatattc cattgggaac aaggcctccc    240

acagctacag atacacttgc tcctgtaaga ccccctttaa cagtagatcc tgtgggccct    300

tctgatcctt ctatagtttc tttagtggaa gaaactagtt ttattgatgc tggtgcacca    360

acatctgtac cttccattcc cccagatgta tcaggattta gtattactac ttcaactgat    420

accacacctg ctatattaga tattaataat actgttacta ctgttactac acataataat    480

cccactttca ctgacccatc tgtattgcag cctccaacac ctgcagaaac tggagggcat    540

tttacacttt catcatccac tattagtaca cataattatg aagaaattcc tatggataca    600

tttattgtta gcacaaaccc taacacagta actagtagca cacccatacc agggtctcgc    660

ccagtggcac gcctaatgca ccaaaagaga actgcaatgt ttcaggaccc acaggagcga    720

cccagaaagt taccacagtt atgcacagag ctgcaaacaa ctatacatga tataatatta    780

gaatgtgtgt actgcaagca acagttactg cgacgtgagg tatatgactt tgcttttcgg    840

gatttatgca tagtatatag agatgggaat ccatatgctg tatgtgataa atgtttaaag    900

ttttattcta aaattagtga gtatagacat tattgttata gtttgtatgg aacaacatta    960

gaacagcaat acaacaaacc gttgtgtgat ttgttaatta ggtgtattaa ctgtcaaaag   1020

ccactgtgtc ctgaagaaaa gcaaagacat ctggacaaaa agcaaagatt ccataatata   1080

aggggtcggt ggaccggtcg atgtatgtct tgttgcagat catcaagaac acgtagagaa   1140

acccagctgt aa                                                       1152


<210>  10
<211>  631
<212>  PRT
<213>  artificial

<220>
<223>  L2(full)-E6

<400>  10

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro 
        115                 120                 125             


Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala 
    130                 135                 140                 


Ile Leu Asp Ile Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn 
145                 150                 155                 160 


Pro Thr Phe Thr Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu 
                165                 170                 175     


Thr Gly Gly His Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn 
            180                 185                 190         


Tyr Glu Glu Ile Pro Met Asp Thr Phe Ile Val Ser Thr Asn Pro Asn 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Pro Ile Pro Gly Ser Arg Pro Val Ala Arg 
    210                 215                 220                 


Leu Gly Leu Tyr Ser Arg Thr Thr Gln Gln Val Lys Val Val Asp Pro 
225                 230                 235                 240 


Ala Phe Val Thr Thr Pro Thr Lys Leu Ile Thr Tyr Asp Asn Pro Ala 
                245                 250                 255     


Tyr Glu Gly Ile Asp Val Asp Asn Thr Leu Tyr Phe Ser Ser Asn Asp 
            260                 265                 270         


Asn Ser Ile Asn Ile Ala Pro Asp Pro Asp Phe Leu Asp Ile Val Ala 
        275                 280                 285             


Leu His Arg Pro Ala Leu Thr Ser Arg Arg Thr Gly Ile Arg Tyr Ser 
    290                 295                 300                 


Arg Ile Gly Asn Lys Gln Thr Leu Arg Thr Arg Ser Gly Lys Ser Ile 
305                 310                 315                 320 


Gly Ala Lys Val His Tyr Tyr Tyr Asp Leu Ser Thr Ile Asp Pro Ala 
                325                 330                 335     


Glu Glu Ile Glu Leu Gln Thr Ile Thr Pro Ser Thr Tyr Thr Thr Thr 
            340                 345                 350         


Ser His Ala Ala Ser Pro Thr Ser Ile Asn Asn Gly Leu Tyr Asp Ile 
        355                 360                 365             


Tyr Ala Asp Asp Phe Ile Thr Asp Thr Ser Thr Thr Pro Val Pro Ser 
    370                 375                 380                 


Val Pro Ser Thr Ser Leu Ser Gly Tyr Ile Pro Ala Asn Thr Thr Ile 
385                 390                 395                 400 


Pro Phe Gly Gly Ala Tyr Asn Ile Pro Leu Val Ser Gly Pro Asp Ile 
                405                 410                 415     


Pro Ile Asn Ile Thr Asp Gln Ala Pro Ser Leu Ile Pro Ile Val Pro 
            420                 425                 430         


Gly Ser Pro Gln Tyr Thr Ile Ile Ala Asp Ala Gly Asp Phe Tyr Leu 
        435                 440                 445             


His Pro Ser Tyr Tyr Met Leu Arg Lys Arg Arg Lys Arg Leu Pro Tyr 
    450                 455                 460                 


Phe Phe Ser Asp Val Ser Leu Ala Ala Met His Gln Lys Arg Thr Ala 
465                 470                 475                 480 


Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
                485                 490                 495     


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            500                 505                 510         


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        515                 520                 525             


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    530                 535                 540                 


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
545                 550                 555                 560 


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                565                 570                 575     


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            580                 585                 590         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        595                 600                 605             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    610                 615                 620                 


Thr Arg Arg Glu Thr Gln Leu 
625                 630     


<210>  11
<211>  1896
<212>  DNA
<213>  artificial

<220>
<223>  L2(full)-E6

<400>  11
atgcgacaca aacgttctgc aaaacgcaca aaacgtgcat cggctaccca actttataaa     60

acatgcaaac aggcaggtac atgtccacct gacattatac ctaaggttga aggcaaaact    120

attgctgaac aaatattaca atatggaagt atgggtgtat tttttggtgg gttaggaatt    180

ggaacagggt cgggtacagg cggacgcact gggtatattc cattgggaac aaggcctccc    240

acagctacag atacacttgc tcctgtaaga ccccctttaa cagtagatcc tgtgggccct    300

tctgatcctt ctatagtttc tttagtggaa gaaactagtt ttattgatgc tggtgcacca    360

acatctgtac cttccattcc cccagatgta tcaggattta gtattactac ttcaactgat    420

accacacctg ctatattaga tattaataat actgttacta ctgttactac acataataat    480

cccactttca ctgacccatc tgtattgcag cctccaacac ctgcagaaac tggagggcat    540

tttacacttt catcatccac tattagtaca cataattatg aagaaattcc tatggataca    600

tttattgtta gcacaaaccc taacacagta actagtagca cacccatacc agggtctcgc    660

ccagtggcac gcctaggatt atatagtcgc acaacacaac aggttaaagt tgtagaccct    720

gcttttgtaa ccactcccac taaacttatt acatatgata atcctgcata tgaaggtata    780

gatgtggata atacattata tttttctagt aatgataata gtattaatat agctccagat    840

cctgactttt tggatatagt tgctttacat aggccagcat taacctctag gcgtactggc    900

attaggtaca gtagaattgg taataaacaa acactacgta ctcgtagtgg aaaatctata    960

ggtgctaagg tacattatta ttatgattta agtactattg atcctgcaga agaaatagaa   1020

ttacaaacta taacaccttc tacatatact accacttcac atgcagcctc acctacttct   1080

attaataatg gattatatga tatttatgca gatgacttta ttacagatac ttctacaacc   1140

ccggtaccat ctgtaccctc tacatcttta tcaggttata ttcctgcaaa tacaacaatt   1200

ccttttggtg gtgcatacaa tattccttta gtatcaggtc ctgatatacc cattaatata   1260

actgaccaag ctccttcatt aattcctata gttccagggt ctccacaata tacaattatt   1320

gctgatgcag gtgactttta tttacatcct agttattaca tgttacgaaa acgacgtaaa   1380

cgtttaccat attttttttc agatgtctct ttggctgcca tgcaccaaaa gagaactgca   1440

atgtttcagg acccacagga gcgacccaga aagttaccac agttatgcac agagctgcaa   1500

acaactatac atgatataat attagaatgt gtgtactgca agcaacagtt actgcgacgt   1560

gaggtatatg actttgcttt tcgggattta tgcatagtat atagagatgg gaatccatat   1620

gctgtatgtg ataaatgttt aaagttttat tctaaaatta gtgagtatag acattattgt   1680

tatagtttgt atggaacaac attagaacag caatacaaca aaccgttgtg tgatttgtta   1740

attaggtgta ttaactgtca aaagccactg tgtcctgaag aaaagcaaag acatctggac   1800

aaaaagcaaa gattccataa tataaggggt cggtggaccg gtcgatgtat gtcttgttgc   1860

agatcatcaa gaacacgtag agaaacccag ctgtaa                             1896


<210>  12
<211>  576
<212>  PRT
<213>  artificial

<220>
<223>  CRF-E6

<400>  12

Met Leu Leu Pro Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Ala 
1               5                   10                  15      


Ala Glu Pro Val Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Glu Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Gln Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Arg 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Pro Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Ala Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Ala Asn 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Thr 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Glu Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Glu 
    370                 375                 380                 


Asp Glu Glu Asp Lys Asp Asp Lys Glu Asp Glu Asp Glu Asp Glu Glu 
385                 390                 395                 400 


Asp Lys Asp Glu Glu Glu Glu Glu Ala Ala Ala Gly Gln Ala Lys Asp 
                405                 410                 415     


Glu Leu Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu 
            420                 425                 430         


Arg Pro Arg Lys Leu Pro His Leu Cys Thr Glu Leu Gln Thr Thr Ile 
        435                 440                 445             


His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg 
    450                 455                 460                 


Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg 
465                 470                 475                 480 


Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser 
                485                 490                 495     


Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr 
            500                 505                 510         


Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys 
        515                 520                 525             


Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu 
    530                 535                 540                 


Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
545                 550                 555                 560 


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
                565                 570                 575     


<210>  13
<211>  1731
<212>  DNA
<213>  artificial

<220>
<223>  CRT-E6

<400>  13
atgctgctcc ctgtgccgct gctgctcggc ctgctcggcc tggccgccgc cgagcccgtc     60

gtctacttca aggagcagtt tctggacgga gatgggtgga ccgagcgctg gatcgaatcc    120

aaacacaagt ccgattttgg caaattcgtc ctcagttcgg gcaagttcta cggcgatcag    180

gagaaagata aagggctgca gaccagccag gacgcccgct tctacgccct gtcggcccga    240

ttcgagccgt tcagcaacaa gggccagcca ctggtggtgc agttcaccgt gaaacacgag    300

cagaacattg actgcggggg cggctacgtg aagctgtttc cggccggcct ggaccagaag    360

gacatgcacg gggactctga gtacaacatc atgtttggtc ctgacatctg tggccccggc    420

accaagaagg ttcacgtcat cttcaactac aagggcaaga acgtgctgat caacaaggac    480

atccgttgca aggacgacga gttcacacac ctgtacacgc tgatcgtgcg gccggacaac    540

acgtatgagg tgaagattga caacagccag gtggagtcgg gctccctgga ggatgactgg    600

gacttcctac cccccaagaa gataaaggac ccagatgcct cgaagcctga agactgggac    660

gagcgggcca agatcgacga ccccacggac tccaagcccg aggactggga caagcccgag    720

cacatccccg acccggacgc gaagaagccc gaagactggg acgaagaaat ggacggagag    780

tgggagccgc cggtgattca gaaccccgag tacaagggtg agtggaagcc gcggcagatc    840

gacaaccccg attacaaagg cacctggatc caccccgaaa tcgacaaccc cgagtactcg    900

cccgacgcta acatctatgc ctacgacagc tttgccgtgc tgggcttgga cctctggcag    960

gtcaagtcgg gcaccatctt cgacaacttc ctcatcacca acgatgaggc gtacgcagag   1020

gagtttggca acgagacgtg gggcgtcacc aagacggccg agaagcagat gaaagacaag   1080

caggacgagg agcagcggct gaaggaggag gaggaggaga agaagcggaa ggaggaggag   1140

gaggccgagg aggacgagga ggacaaggac gacaaggagg acgaggatga ggacgaggag   1200

gacaaggacg aggaggagga ggaggcggcc gccggccagg ccaaggacga gctgatgcac   1260

caaaagagaa ctgcaatgtt tcaggaccca caggagcgac ccagaaagtt accacagtta   1320

tgcacagagc tgcaaacaac tatacatgat ataatattag aatgtgtgta ctgcaagcaa   1380

cagttactgc gacgtgaggt atatgacttt gcttttcggg atttatgcat agtatataga   1440

gatgggaatc catatgctgt atgtgataaa tgtttaaagt tttattctaa aattagtgag   1500

tatagacatt attgttatag tttgtatgga acaacattag aacagcaata caacaaaccg   1560

ttgtgtgatt tgttaattag gtgtattaac tgtcaaaagc cactgtgtcc tgaagaaaag   1620

caaagacatc tggacaaaaa gcaaagattc cataatataa ggggtcggtg gaccggtcga   1680

tgtatgtctt gttgcagatc atcaagaaca cgtagagaaa cccagctgta a            1731


