                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado
       Hutton, John
       Wenzlau, Jan
       Jensen, Jan
       Davidson, Howard
 
<120>  Diagnostic and Therapeutic Target for Autoimmune Diseases and 
       Uses Thereof

<130>  2848-94-PCT

<150>  60/882,815
<151>  2006-12-29

<160>  67    

<170>  PatentIn version 3.4

<210>  1
<211>  5373
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (231)..(1340)

<400>  1
agcagttttt gtaggtgaaa acaatgaagc caggtaatat tgcaaggagg ctgtaatttt     60

agcagaccta ccaacaacac tgatgtagga agctcattat tttaatttct ggagcctttt    120

aattttttct ttagaaagtg tataaataat tgcagtgctg ctttgcttcc aaaactgggc    180

agtgagttca acaacaacga caacaacagc cgcagctcat cctggccgtc atg gag       236
                                                       Met Glu          
                                                       1                

ttt ctt gaa aga acg tat ctt gtg aat gat aaa gct gcc aag atg tat      284
Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys Met Tyr         
        5                   10                  15                      

gct ttc aca cta gaa agt gtg gaa ctc caa cag aaa ccg gtg aat aaa      332
Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val Asn Lys         
    20                  25                  30                          

gat cag tgt ccc aga gag aga cca gag gag ctg gag tca gga ggc atg      380
Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly Gly Met         
35                  40                  45                  50          

tac cac tgc cac agt ggc tcc aag ccc aca gaa aag ggg gcg aat gag      428
Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala Asn Glu         
                55                  60                  65              

tac gcc tat gcc aag tgg aaa ctc tgt tct gct tca gca ata tgc ttc      476
Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile Cys Phe         
            70                  75                  80                  

att ttc atg att gca gag gtc gtg ggt ggg cac att gct ggg agt ctt      524
Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly Ser Leu         
        85                  90                  95                      

gct gtt gtc aca gat gct gcc cac ctc tta att gac ctg acc agt ttc      572
Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr Ser Phe         
    100                 105                 110                         

ctg ctc agt ctc ttc tcc ctg tgg ttg tca tcg aag cct ccc tct aag      620
Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro Ser Lys         
115                 120                 125                 130         

cgg ctg aca ttt gga tgg cac cga gca gag atc ctt ggt gcc ctg ctc      668
Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala Leu Leu         
                135                 140                 145             

tcc atc ctg tgc atc tgg gtg gtg act ggc gtg cta gtg tac ctg gca      716
Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr Leu Ala         
            150                 155                 160                 

tgt gag cgc ctg ctg tat cct gat tac cag atc cag gcg act gtg atg      764
Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr Val Met         
        165                 170                 175                     

atc atc gtt tcc agc tgc gca gtg gcg gcc aac att gta cta act gtg      812
Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu Thr Val         
    180                 185                 190                         

gtt ttg cac cag aga tgc ctt ggc cac aat cac aag gaa gta caa gcc      860
Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val Gln Ala         
195                 200                 205                 210         

aat gcc agc gtc aga gct gct ttt gtg cat gcc ctt gga gat cta ttt      908
Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp Leu Phe         
                215                 220                 225             

cag agt atc agt gtg cta att agt gca ctt att atc tac ttt aag cca      956
Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe Lys Pro         
            230                 235                 240                 

gag tat aaa ata gcc gac cca atc tgc aca ttc atc ttt tcc atc ctg     1004
Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser Ile Leu         
        245                 250                 255                     

gtc ttg gcc agc acc atc act atc tta aag gac ttc tcc atc tta ctc     1052
Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile Leu Leu         
    260                 265                 270                         

atg gaa ggt gtg cca aag agc ctg aat tac agt ggt gtg aaa gag ctt     1100
Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys Glu Leu         
275                 280                 285                 290         

att tta gca gtc gac ggg gtg ctg tct gtg cac agc ctg cac atc tgg     1148
Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His Ile Trp         
                295                 300                 305             

tct cta aca atg aat caa gta att ctc tca gct cat gtt gct aca gca     1196
Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala Thr Ala         
            310                 315                 320                 

gcc agc cgg gac agc caa gtg gtt cgg aga gaa att gct aaa gcc ctt     1244
Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys Ala Leu         
        325                 330                 335                     

agc aaa agc ttt acg atg cac tca ctc acc att cag atg gaa tct cca     1292
Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu Ser Pro         
    340                 345                 350                         

gtt gac cag gac ccc gac tgc ctt ttc tgt gaa gac ccc tgt gac tag     1340
Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys Asp             
355                 360                 365                             

ctcagtcaca ccgtcagttt cccaaatttg acaggccacc ttcaaacatg ctgctatgca   1400

gtttctgcat catagaaaat aaggaaccaa aggaagaaat tcatgtcatg gtgcaatgca   1460

cattttatct atttatttag ttccattcac catgaaggaa gaggcactga gatccatcaa   1520

tcaattggat tatatactga tcagtagctg tgttcaattg caggaatgtg tatatagatt   1580

attcctgagt ggagccgaag taacagctgt ttgtaactat cggcaatacc aaattcatct   1640

cccttccaat aatgcatctt gagaacacat aggtaaattt gaactcagga aagtcttact   1700

agaaatcagt ggaagggaca aatagtcaca aaattttacc aaaacattag aaacaaaaaa   1760

taaggagagc caagtcagga ataaaagtga ctctgtatgc taacgccaca ttagaacttg   1820

gttctctcac caagctgtaa tgtgattttt ttttctactc tgaattggaa atatgtatga   1880

atatacagag aagtgcttac aactaatttt tatttacttg tcacattttg gcaataaatc   1940

cctcttattt ctaaattcta acttgtttat ttcaaaactt tatataatca ctgttcaaaa   2000

ggaaatattt tcacctacca gagtgcttaa acactggcac cagccaaaga atgtggttgt   2060

agagacccag aagtcttcaa gaacagccga caaaaacatt cgagttgacc ccaccaagtt   2120

gttgccacag ataatttaga tatttacctg caagaaggaa taaagcagat gcaaccaatt   2180

cattcagtcc acgagcatga tgtgagcact gctttgtgct agacattggg cttagcattg   2240

aaactataaa gaggaatcag acgcagcaag tgcttctgtg ttctggtagc aactcaacac   2300

tatctgtgga gagtaaactg aagatgtgca ggccaacatt ctggaaatcc tatgtcaatg   2360

ggtttggttt ggaacctgga cttctgcatt tttaaaagtt acccagagat gcttctaaag   2420

atgagccata gtctagaaga ttgtcaacca caggagttca ttgagtggga cagctagaca   2480

catacattgg cagctacaat agtatcatga attgcaatga tgtagtgggg tataaaagga   2540

aagcgatgga tattgccgga tgggcatggc cagtgatgtt tcacgtcatt gaggtgacag   2600

ctctgctgga ctttgaatta catatggagg ctctccagga agacgaagaa gagaaggaca   2660

ttctaggcaa aaagaagact aggcacaagg cacacttatg tttgtctgtt agcttttagt   2720

tgaaaaagca aaatacatga tgcaaagaaa cctctccacg ctgtgatttt taaaactaca   2780

tactttttgc aactttatgg ttatgagtat tgtagagaac aggagatagg tcttagatga   2840

tttttatgtt gttgtcagac tctagcaagg tactagaaac ctagcaggca ttaataattg   2900

ttgaggcaat gactctgagg ctatatctgg gccttgtcat tatttatcat ttatatttgt   2960

atttttttct gaaatttgag ggccaagaaa acattgactt tgactgagga ggtcacatct   3020

gtgccatctc tgcaaatcaa tcagcaccac tgaaataact acttagcatt ctgctgagct   3080

ttccctgctc agtagagaca aatatactca tcccccacct cagtgagctt gtttaggcaa   3140

ccaggattag agctgctcag gttcccaacg tctcctgcca catcgggttc tcaaaatgga   3200

aagaatggtt tatgccaaat cacttttcct gtctgaagga ccactgaatg gttttgtttt   3260

tccatatttt gcataggacg ccctaaagac taggtgactt ggcaaacaca caagtgttag   3320

tataattctt tgcttctgct tctttttgaa aatcatgttt agatttgatt ttaagtcaga   3380

aattcactga atgtcaggta atcattatgg agggagattt gtgtgtcaac caaagtaatt   3440

gtcccatggc cccagggtat ttctgttgtt tccctgaaat tctgcttttt tagtcagcta   3500

gattgaaaac tctgaacagt agatgtttat atggcaaaat gcaagacaat ctacaaggga   3560

gattttaagg attttgagat gaaaaaacag atgctactca ggggctttat gaaccatcca   3620

tcaattctga agttctgact ctcccattac cctttccctg gtgtggtcag aactccaggt   3680

cactggaagt tagtggaatc atgtagttga attctttact tcaagacatt gtattctctc   3740

cagctatcaa aacattaatg atcttttatg tctttttttt gttattgtta tactttaagt   3800

tctggggtac atgtgcggaa catgtaggtt tgttacatag gtatacatgt gccatggtgg   3860

tttgctgcac tcatcaacct gtcatctaca ttcttttatg tctgtctttc aaagcaacac   3920

tctgttcttc tgagtagtga aatcaggtca actttaccac cagcctccat ttttaatatg   3980

cttcaccatc atccagcacc tacttaagat ttatctaggg ctctgtggtg atgttaggac   4040

ccataaaaga aatttatgcc ttccatatgt ttggttacag atgggaaatg ggaatgttga   4100

aggacatgaa agaaaggatg tttacacatt aagcatcagt tctgaagcta gattgtctga   4160

gtttgaatct tagctcttcc ctttattagc tctgtgacct cgagctagtt acttaaatgc   4220

tctgatcctc tatttcctga tcagtgaaac ctccctattc aaatgtgtga gagtttaata   4280

aattaggaca cttaaaaatg ttggagcagt gcatagcatg tagtgttcag tacatgttaa   4340

atgttgtttt ttattatgta caaacatgag tgggcacaga attttaaatc atctcaactt   4400

ttgagaaatt ttgagttatc aacaccgttc ccacaagaca gtggcaaaat tattggtgag   4460

aattaaacag ctgtttctca gaggaagcaa tggaggcttg ctgggataaa ggcatttact   4520

gagaggctgt tacctagtga gagtgatgaa ttaattaaaa tagtcgaatc cctttctgac   4580

tgtctctgaa agcttccgct tttatctttg aagagcagaa ttgtcactcc aaggacattt   4640

attaataaaa agaacaactg tccagtgcaa tgaaggcaaa gtcataggtc tcccaagtct   4700

taccccattc ctgtgaaata tcaagttctt ggcttttctc tgtcatgtag cctcaacttt   4760

ctctgaccgg gtgcatttct ttctctggtt tctaaattgc cagtggcaaa tttggatcac   4820

ttacttaata tctgttaaat tttgtgaccc aacaaagtct tttagcactg tggtgtcaaa   4880

aagaaaaaca cctcccaggc atatacattt tatagattcc tggagaatgt tgctctccag   4940

ctccatcccc acccaatgaa atatgatcca gagagtcttg caaagagaca agcctcattt   5000

tccacaatta gctctaaagt gcctccagga aatgattttc tcagctcatc tctctgtatt   5060

ccctgttttg gatcacaggg caatctgttt aaatgactaa ttacagaaat cattaaaggc   5120

accaagcaaa tgtcatctct gaatacacac atcccaagct ttacaaatcc tgcctggctt   5180

gacagtgatg aggccactta acagtccagc gcaggcggat gttaaaaaaa ataaaaaggt   5240

gaccatctgc ggtttagttt tttaactttc tgatttcaca cttaacgtct gtcattctgt   5300

tactgggcac ctgtttaaat tctattttaa aatgttaatg tgtgttgttt aaaataaaat   5360

caagaaagag aga                                                      5373


<210>  2
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly 
                85                  90                  95      


Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 
            100                 105                 110         


Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro 
        115                 120                 125             


Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr 
                165                 170                 175     


Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu 
            180                 185                 190         


Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val 
        195                 200                 205             


Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp 
    210                 215                 220                 


Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe 
225                 230                 235                 240 


Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser 
                245                 250                 255     


Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile 
            260                 265                 270         


Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys 
        275                 280                 285             


Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His 
    290                 295                 300                 


Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 
305                 310                 315                 320 


Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 
                325                 330                 335     


Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 
            340                 345                 350         


Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 
        355                 360                 365             


Asp 
    


<210>  3
<211>  1906
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (334)..(1437)

<400>  3
atgtgcgcgc acgcgcgcgc gcacacacac acacacacac acacacacac acacacacac     60

acacttatta caattgtacc tttgagtctc ccagaaaagc agtttctgtg agtgatagaa    120

tgagtctagg tgattttcca aggagactgt taattttcac agatttaccc acaacactga    180

tataggaggc ctcattaact caagtactgg aagaattttt ctaatttctt aggaagttgt    240

gtgaatataa taatatcagt gcttctttac ttccaaaact ggacagcgca tcaaacatca    300

gaaacaacag tatcagctcc tgtcccaact acc atg gag ttt ctt gag aga act     354
                                     Met Glu Phe Leu Glu Arg Thr        
                                     1               5                  

tat ctt gtg aat gat caa gcc acc aag atg tac gcc ttc cct cta gac      402
Tyr Leu Val Asn Asp Gln Ala Thr Lys Met Tyr Ala Phe Pro Leu Asp         
        10                  15                  20                      

aga gaa ctt cga cag aag cct gtg aat aaa gat cag tgt cct gga gac      450
Arg Glu Leu Arg Gln Lys Pro Val Asn Lys Asp Gln Cys Pro Gly Asp         
    25                  30                  35                          

agg cca gag cat cca gag gca gga ggc atc tat cac tgc cac aac agc      498
Arg Pro Glu His Pro Glu Ala Gly Gly Ile Tyr His Cys His Asn Ser         
40                  45                  50                  55          

gcc aag gcc aca ggg aac agg tcg agc aag caa gcg cat gcc aag tgg      546
Ala Lys Ala Thr Gly Asn Arg Ser Ser Lys Gln Ala His Ala Lys Trp         
                60                  65                  70              

aga ctc tgt gct gct tca gca ata tgc ttc atc ttt atg gtg gca gag      594
Arg Leu Cys Ala Ala Ser Ala Ile Cys Phe Ile Phe Met Val Ala Glu         
            75                  80                  85                  

gtg gtg ggt gga cac gtt gct ggg agt ctg gct atc ctc act gat gcg      642
Val Val Gly Gly His Val Ala Gly Ser Leu Ala Ile Leu Thr Asp Ala         
        90                  95                  100                     

gct cat ctc tta att gac ctg act agt ttc ctg ctc agt ctc ttt tct      690
Ala His Leu Leu Ile Asp Leu Thr Ser Phe Leu Leu Ser Leu Phe Ser         
    105                 110                 115                         

ttg tgg ttg tca tcg agg ccc cct tcc aag cgg ctg aca ttt ggg tgg      738
Leu Trp Leu Ser Ser Arg Pro Pro Ser Lys Arg Leu Thr Phe Gly Trp         
120                 125                 130                 135         

tat cga gca gag atc ctc ggt gcc ctg ctg tct gtc ctt tgc atc tgg      786
Tyr Arg Ala Glu Ile Leu Gly Ala Leu Leu Ser Val Leu Cys Ile Trp         
                140                 145                 150             

gtg gtg act ggt gtg ctg ctg tac ctt gcc tgt gag cgc ctt ttg tat      834
Val Val Thr Gly Val Leu Leu Tyr Leu Ala Cys Glu Arg Leu Leu Tyr         
            155                 160                 165                 

cct gat tac cag atc caa gca ggt atc atg atc act gtt tca ggc tgt      882
Pro Asp Tyr Gln Ile Gln Ala Gly Ile Met Ile Thr Val Ser Gly Cys         
        170                 175                 180                     

gca gtg gca gcc aac att gta cta act atg att ttg cac caa cgg aac      930
Ala Val Ala Ala Asn Ile Val Leu Thr Met Ile Leu His Gln Arg Asn         
    185                 190                 195                         

ttt ggc tac aac cac aag gat gta caa gct aat gcc agt gtc cga gca      978
Phe Gly Tyr Asn His Lys Asp Val Gln Ala Asn Ala Ser Val Arg Ala         
200                 205                 210                 215         

gcc ttt gtg cat gcc ctg ggg gat gta ttt cag agc atc agt gtg cta     1026
Ala Phe Val His Ala Leu Gly Asp Val Phe Gln Ser Ile Ser Val Leu         
                220                 225                 230             

att agt gct ctc att atc tac ttt aag cct gac tac aaa att gct gat     1074
Ile Ser Ala Leu Ile Ile Tyr Phe Lys Pro Asp Tyr Lys Ile Ala Asp         
            235                 240                 245                 

cca gtg tgc aca ttt atc ttt tcc atc ctg gtt ttg gcc agc acc gtc     1122
Pro Val Cys Thr Phe Ile Phe Ser Ile Leu Val Leu Ala Ser Thr Val         
        250                 255                 260                     

atg atc tta aaa gac ttc tcc atc tta ctc atg gaa ggt gtt cca aag     1170
Met Ile Leu Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys         
    265                 270                 275                         

ggc ctg agt tac aac agt gtg aaa gag atc atc ctc gca gtt gat ggc     1218
Gly Leu Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly         
280                 285                 290                 295         

gtg atc tcc gtg cac agt cta cac atc tgg tca ctg act gtg aac caa     1266
Val Ile Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln         
                300                 305                 310             

gtg att ctc tct gtt cat gtt gct aca gct gcc agc cag gac agc cag     1314
Val Ile Leu Ser Val His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln         
            315                 320                 325                 

tct gtg cgg aca gga att gct caa gcc ctc agc agc ttt gat ctt cac     1362
Ser Val Arg Thr Gly Ile Ala Gln Ala Leu Ser Ser Phe Asp Leu His         
        330                 335                 340                     

tct ctt acc att cag ata gaa tct gca gca gac cag gac ccc agc tgc     1410
Ser Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys         
    345                 350                 355                         

ctt ctc tgc gaa gac cct cag gac tag ctcggtcaca ctgtcagctt           1457
Leu Leu Cys Glu Asp Pro Gln Asp                                         
360                 365                                                 

cctgtgtttc ctaggccatg ataagatgca gcaaagtttc tgcaatgcac aatgaggcag   1517

ccgtcggaat agatttgaga aagtcatgat gatgcaatgt gcacactctt cctttgtatt   1577

tatctctatc caccatgaac gaggatgcat gggatttgtc ggcttcttgg attatacact   1637

aatcagtagt tgtgctcaat tgtagtatat atagattatt cctaactgga gctgaaataa   1697

cagatgtttg caatcatagg taatgaatga ttcacttgcc tacaatagtg ggtatagttt   1757

tactcggaaa tgcctttcta ggaatccaca gcatgagaaa caaacatttg aagagaattt   1817

gaggccttag aatttgattc tgccaccata ctcaatgaga tctttatttt ttgtgaaaca   1877

gtaaaacttc cctcttttga ccttgcatg                                     1906


<210>  4
<211>  367
<212>  PRT
<213>  Mus musculus

<400>  4

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Gln Ala Thr Lys 
1               5                   10                  15      


Met Tyr Ala Phe Pro Leu Asp Arg Glu Leu Arg Gln Lys Pro Val Asn 
            20                  25                  30          


Lys Asp Gln Cys Pro Gly Asp Arg Pro Glu His Pro Glu Ala Gly Gly 
        35                  40                  45              


Ile Tyr His Cys His Asn Ser Ala Lys Ala Thr Gly Asn Arg Ser Ser 
    50                  55                  60                  


Lys Gln Ala His Ala Lys Trp Arg Leu Cys Ala Ala Ser Ala Ile Cys 
65                  70                  75                  80  


Phe Ile Phe Met Val Ala Glu Val Val Gly Gly His Val Ala Gly Ser 
                85                  90                  95      


Leu Ala Ile Leu Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr Ser 
            100                 105                 110         


Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Arg Pro Pro Ser 
        115                 120                 125             


Lys Arg Leu Thr Phe Gly Trp Tyr Arg Ala Glu Ile Leu Gly Ala Leu 
    130                 135                 140                 


Leu Ser Val Leu Cys Ile Trp Val Val Thr Gly Val Leu Leu Tyr Leu 
145                 150                 155                 160 


Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Gly Ile 
                165                 170                 175     


Met Ile Thr Val Ser Gly Cys Ala Val Ala Ala Asn Ile Val Leu Thr 
            180                 185                 190         


Met Ile Leu His Gln Arg Asn Phe Gly Tyr Asn His Lys Asp Val Gln 
        195                 200                 205             


Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp Val 
    210                 215                 220                 


Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe Lys 
225                 230                 235                 240 


Pro Asp Tyr Lys Ile Ala Asp Pro Val Cys Thr Phe Ile Phe Ser Ile 
                245                 250                 255     


Leu Val Leu Ala Ser Thr Val Met Ile Leu Lys Asp Phe Ser Ile Leu 
            260                 265                 270         


Leu Met Glu Gly Val Pro Lys Gly Leu Ser Tyr Asn Ser Val Lys Glu 
        275                 280                 285             


Ile Ile Leu Ala Val Asp Gly Val Ile Ser Val His Ser Leu His Ile 
    290                 295                 300                 


Trp Ser Leu Thr Val Asn Gln Val Ile Leu Ser Val His Val Ala Thr 
305                 310                 315                 320 


Ala Ala Ser Gln Asp Ser Gln Ser Val Arg Thr Gly Ile Ala Gln Ala 
                325                 330                 335     


Leu Ser Ser Phe Asp Leu His Ser Leu Thr Ile Gln Ile Glu Ser Ala 
            340                 345                 350         


Ala Asp Gln Asp Pro Ser Cys Leu Leu Cys Glu Asp Pro Gln Asp 
        355                 360                 365         


<210>  5
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala Asn 
1               5                   10                  15      


Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile Cys 
            20                  25                  30          


Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly Ser 
        35                  40                  45              


Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr Ser 
    50                  55                  60                  


Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro Ser 
65                  70                  75                  80  


Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala Leu 
                85                  90                  95      


Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr Leu 
            100                 105                 110         


Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr Val 
        115                 120                 125             


Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu Thr 
    130                 135                 140                 


Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val Gln 
145                 150                 155                 160 


Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp Leu 
                165                 170                 175     


Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe Lys 
            180                 185                 190         


Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser Ile 
        195                 200                 205             


Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile Leu 
    210                 215                 220                 


Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys Glu 
225                 230                 235                 240 


Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His Ile 
                245                 250                 255     


Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala Thr 
            260                 265                 270         


Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys Ala 
        275                 280                 285             


Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu Ser 
    290                 295                 300                 


Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys Asp 
305                 310                 315                 320 


<210>  6
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Phe Leu Glu Arg Ala Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Arg Arg Ser Cys Lys 
            20                  25              


<210>  7
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Arg Arg Ser Arg Lys 
            20                  25              


<210>  8
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu 
65                  70                  


<210>  9
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp 
            100             


<210>  10
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser 
                85          


<210>  11
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met 
65                  70                  75              


<210>  12
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Ala Ser Phe Thr Met Ala Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Ala Ala Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp 
            100             


<210>  13
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Leu Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys 
1               5                   10                  15      


Glu Val Gln Ala Asn Ala Ser Val Arg Ala 
            20                  25      


<210>  14
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys Glu Leu 
1               5                   10                  15      


Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His Ile Trp 
            20                  25                  30          


Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala Thr Ala 
        35                  40                  45              


Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys Ala Leu 
    50                  55                  60                  


Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu Ser Pro 
65                  70                  75                  80  


Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys Asp 
                85                  90                  95  


<210>  15
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
1               5                   10                  15      


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
            20                  25                  30          


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val 
        35                  40                  45              


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
    50                  55                  60                  


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
65                  70                  75                  80  


Leu Phe Cys Glu Asp Pro Cys Asp 
                85              


<210>  16
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His Ile 
1               5                   10                  15      


Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala Thr 
            20                  25                  30          


Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys Ala 
        35                  40                  45              


Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu Ser 
    50                  55                  60                  


Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys Asp 
65                  70                  75                  80  


<210>  17
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  17

Met His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu 
1               5                   10                  15      


Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg 
            20                  25                  30          


Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu 
        35                  40                  45              


Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe 
    50                  55                  60                  


Cys Glu Asp Pro Cys Asp 
65                  70  


<210>  18
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 
1               5                   10                  15      


Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 
            20                  25                  30          


Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 
        35                  40                  45              


Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 
    50                  55                  60                  


Asp 
65  


<210>  19
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn 
1               5                   10                  15      


Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala 
            20                  25      


<210>  20
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn 
1               5                   10                  15      


Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser 
            20                  25                  30          


Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu 
        35                  40                  45              


Ser Ala His Val Ala Thr Ala Ala Ser 
    50                  55          


<210>  21
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn 
1               5                   10                  15      


Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser 
            20                  25                  30          


Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu 
        35                  40                  45              


Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg 
    50                  55                  60                  


Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr 
65                  70                  75      


<210>  22
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn 
1               5                   10                  15      


Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser 
            20                  25                  30          


Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu 
        35                  40                  45              


Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg 
    50                  55                  60                  


Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu 
65                  70                  75                  80  


Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe 
                85                  90                  95      


Cys Glu Asp Pro Cys Asp 
            100         


<210>  23
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn 
1               5                   10                  15      


Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser 
            20                  25                  30          


Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu 
        35                  40                  45              


Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg 
    50                  55                  60                  


Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu 
65                  70                  75                  80  


Thr Ile Gln Met Glu Ser Pro Val Asp 
                85                  


<210>  24
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn 
1               5                   10                  15      


Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser 
            20                  25                  30          


Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu 
        35                  40                  45              


Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg 
    50                  55                  60                  


Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu 
65                  70                  75                  80  


Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe 
                85                  90                  95      


Cys Glu Asp Pro Cys Asp 
            100         


<210>  25
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  25

Arg Asp Val Leu Leu Val Leu Met Glu Gly Ala Pro Arg Ser Val Glu 
1               5                   10                  15      


Phe Glu Pro Val Arg Asp Thr Leu Leu Ser Val Pro Gly Val Arg Ala 
            20                  25                  30          


Thr His Asp Leu His Leu Trp Ala Leu Thr Leu Thr Tyr His Val Ala 
        35                  40                  45              


Ser Ala His Leu Ala Ile Asp Ser Thr Ala Asp Pro Glu Ala Val Leu 
    50                  55                  60                  


Ala Glu Ala Ser Ser Arg Leu Tyr Ser Arg Phe Gly Phe Ser Ser Cys 
65                  70                  75                  80  


Thr Leu Gln Val Glu Gln Tyr Gln Pro Glu Met Ala Gln Cys Leu Arg 
                85                  90                  95      


Cys Gln Glu Pro Ser Gln Ala 
            100             


<210>  26
<211>  17
<212>  PRT
<213>  Macaca mulatta

<400>  26

Phe Thr Val Tyr Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln 
1               5                   10                  15      


Asp 
    


<210>  27
<211>  17
<212>  PRT
<213>  Canis familiaris

<400>  27

Tyr Thr Val His Ser Leu Thr Ile Gln Met Glu Ser Pro Ala Asp Gln 
1               5                   10                  15      


Asp 
    


<210>  28
<211>  17
<212>  PRT
<213>  Rattus rattus

<400>  28

Phe Asp Leu His Ser Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln 
1               5                   10                  15      


Asp 
    


<210>  29
<211>  17
<212>  PRT
<213>  Bos taurus

<400>  29

Phe Pro Val His Ser Leu Thr Ile Gln Met Ser Cys Ser Pro Thr Arg 
1               5                   10                  15      


Ile 
    


<210>  30
<211>  17
<212>  PRT
<213>  Xenopus sp.

<400>  30

Phe Pro Phe His Ser Val Thr Ile Gln Val Glu Pro Ile Glu Asp Gln 
1               5                   10                  15      


Ser 
    


<210>  31
<211>  17
<212>  PRT
<213>  Gallus gallus

<400>  31

Tyr Ser Phe His Ser Ile Thr Ile Gln Ile Glu Ser Gly Gly Asp Gln 
1               5                   10                  15      


Glu 
    


<210>  32
<211>  17
<212>  PRT
<213>  Danio rerio

<400>  32

Tyr Ser Phe His Ser Val Thr Ile Gln Leu Glu Pro Gln Ala Asp Gln 
1               5                   10                  15      


Arg 
    


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  33

Phe His Phe His Thr Val Thr Ile Gln Ile Glu Asp Tyr Ser Glu Asp 
1               5                   10                  15      


Met 
    


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  34

Phe Gly Phe Ser Ser Cys Thr Leu Gln Val Glu Gln Tyr Gln Pro Glu 
1               5                   10                  15      


Met 
    


<210>  35
<211>  17
<212>  PRT
<213>  Pyrococcus sp.

<400>  35

Phe Gly Ile Thr His Val Thr Ile Gln Leu Glu Thr Gly Arg Cys Lys 
1               5                   10                  15      


Glu 
    


<210>  36
<211>  17
<212>  PRT
<213>  Escherichia coli

<400>  36

Val Asp Gly Asn Gln Ile Thr Ile Gln Met Glu Ser Lys Ile Asp Val 
1               5                   10                  15      


Gln 
    


<210>  37
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Met His Asp Leu Thr Thr Ile Gln Gly Asp Glu Pro Val Gly Gln 
1               5                   10                  15      


Arg 
    


<210>  38
<211>  69
<212>  PRT
<213>  Xenopus sp.

<400>  38

Met Lys Gly Ser Glu Glu Ala Tyr Leu Val Ser Asp Lys Ala Thr Lys 
1               5                   10                  15      


Met Tyr Ser Leu Thr Lys Asp Ser Glu Lys Asn His Pro Ser Lys Pro 
            20                  25                  30          


Pro Leu Gln Asp Glu Glu Asn Pro Gln Ser Lys Tyr His Cys His Asn 
        35                  40                  45              


Asn Asn Lys Lys Ala Tyr Asp Ala Arg Gln Arg Glu Gln Thr Phe Ala 
    50                  55                  60                  


Lys Lys Lys Leu Cys 
65                  


<210>  39
<211>  102
<212>  PRT
<213>  Xenopus sp.

<400>  39

Arg Asp Leu Leu Thr Val Leu Met Glu Gly Thr Arg Pro Gly Ile His 
1               5                   10                  15      


Tyr Ser Asp Val Lys Gln Ser Ile Leu Ala Val Asp Gly Val Lys Ser 
            20                  25                  30          


Val His Ser Leu His Leu Trp Ala Leu Thr Met Asn Gln Val Ile Leu 
        35                  40                  45              


Ser Ala His Ile Ala Thr Asp Ile Val Gly Glu Ser Lys Arg Ile Leu 
    50                  55                  60                  


Lys Asp Val Thr Gln Asn Val Phe Ala Arg Phe Pro Phe His Ser Val 
65                  70                  75                  80  


Thr Ile Gln Val Glu Pro Ile Glu Asp Gln Ser Pro Glu Cys Met Phe 
                85                  90                  95      


Cys Tyr Glu Pro Thr Gln 
            100         


<210>  40
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  40

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Thr Gly Ile Ala Gln Ala Leu Ser Ser Phe Asp Leu His Ser Leu 
65                  70                  75                  80  


Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu Leu 
                85                  90                  95      


Cys Glu Asp Pro Gln Asp 
            100         


<210>  41
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  41

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Thr Gly Ile Ala Gln Ala Leu Ser Ser Phe Asp Leu His Ser Leu 
65                  70                  75                  80  


Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu Leu 
                85                  90                  95      


Cys Glu Asp Pro Gln Asp 
            100         


<210>  42
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  42

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Thr Gly Ile Ala Gln Ala Leu Ser Ser Phe Asp Leu His Ser Leu 
65                  70                  75                  80  


Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu Leu 
                85                  90                  95      


Cys Glu Asp Pro Gln Asp 
            100         


<210>  43
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  43

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Thr Gly Ile Ala Gln Ala Leu Ser Lys Ser Phe Asp Leu His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu 
                85                  90                  95      


Leu Cys Glu Asp Pro Gln Asp 
            100             


<210>  44
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  44

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Thr Gly Ile Ala Gln Ala Leu Ser Lys Ser Phe Asp Leu His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu 
                85                  90                  95      


Leu Cys Glu Asp Pro Gln Asp 
            100             


<210>  45
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  45

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Thr Gly Ile Ala Gln Ala Leu Ser Lys Ser Phe Asp Leu His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu 
                85                  90                  95      


Leu Cys Glu Asp Pro Gln Asp 
            100             


<210>  46
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  46

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Asp Leu His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu 
                85                  90                  95      


Leu Cys Glu Asp Pro Gln Asp 
            100             


<210>  47
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  47

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Asp Leu His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu 
                85                  90                  95      


Leu Cys Glu Asp Pro Gln Asp 
            100             


<210>  48
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  48

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Ser Val Lys Glu Ile Ile Leu Ala Val Asp Gly Val Ile 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Val Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Val His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Ser Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Asp Leu His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser Cys Leu 
                85                  90                  95      


Leu Cys Glu Asp Pro Gln Asp 
            100             


<210>  49
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp 
            100             


<210>  50
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp 
            100             


<210>  51
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp 
            100             


<210>  52
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  52

Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Gly 
1               5                   10      


<210>  53
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  54
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  55
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  56
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  57
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  58
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Trp Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  59
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  60
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  61
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Pro Ser Thr Pro Pro Gly Ser Ser Gly 
            100                 105                 110         


Gly Gly Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser 
        115                 120                 125             


Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val 
    130                 135                 140                 


Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val 
145                 150                 155                 160 


Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser Gln Asp Ser Gln Val 
                165                 170                 175     


Val Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His 
            180                 185                 190         


Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys 
        195                 200                 205             


Leu Phe Cys Glu Asp Pro Cys Asp 
    210                 215     


<210>  62
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Gly Gly Gly Lys 
65                  70                  75                  80  


Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr 
                85                  90                  95      


Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val 
            100                 105                 110         


His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser 
        115                 120                 125             


Ala His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val Arg Arg 
    130                 135                 140                 


Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr 
145                 150                 155                 160 


Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys 
                165                 170                 175     


Glu Asp Pro Cys Asp 
            180     


<210>  63
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Gly Gly Gly Lys 
65                  70                  75                  80  


Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr 
                85                  90                  95      


Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val 
            100                 105                 110         


His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser 
        115                 120                 125             


Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg 
    130                 135                 140                 


Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr 
145                 150                 155                 160 


Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys 
                165                 170                 175     


Glu Asp Pro Cys Asp 
            180     


<210>  64
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala Asn 
1               5                   10                  15      


Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Gly Gly Gly Lys Asp 
            20                  25                  30          


Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser 
        35                  40                  45              


Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His 
    50                  55                  60                  


Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala 
65                  70                  75                  80  


His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val Arg Arg Glu 
                85                  90                  95      


Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile 
            100                 105                 110         


Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu 
        115                 120                 125             


Asp Pro Cys Asp 
    130         


<210>  65
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala Asn 
1               5                   10                  15      


Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Gly Gly Gly Lys Asp 
            20                  25                  30          


Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser 
        35                  40                  45              


Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His 
    50                  55                  60                  


Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala 
65                  70                  75                  80  


His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu 
                85                  90                  95      


Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile 
            100                 105                 110         


Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu 
        115                 120                 125             


Asp Pro Cys Asp 
    130         


<210>  66
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu 
1               5                   10                  15      


Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu 
            20                  25                  30          


Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile 
        35                  40                  45              


Leu Ser Ala His Val Ala Thr Ala Ala Ser Arg Asp Ser Gln Val Val 
    50                  55                  60                  


Arg Arg Glu Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser 
65                  70                  75                  80  


Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu 
                85                  90                  95      


Phe Cys Glu Asp Pro Cys Asp Gly Gly Gly Met Glu Phe Leu Glu Arg 
            100                 105                 110         


Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys Met Tyr Ala Phe Thr Leu 
        115                 120                 125             


Glu Ser Val Glu Leu Gln Gln Lys Pro Val Asn Lys Asp Gln Cys Pro 
    130                 135                 140                 


Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly Gly Met Tyr His Cys His 
145                 150                 155                 160 


Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala Asn Glu Tyr Ala Tyr Ala 
                165                 170                 175     


Lys Trp Lys Leu Cys Ser 
            180         


<210>  67
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Asp Ala 
65                  70                  75                  80  


Ala His Leu Leu Ile Asp Ser Ser Lys Pro Pro Ser Lys Arg Leu Thr 
                85                  90                  95      


Phe Gly Trp His Arg Ala Glu Cys Glu Arg Leu Leu Tyr Pro Asp Tyr 
            100                 105                 110         


Gln Ile Gln Ala Thr Leu His Gln Arg Cys Leu Gly His Asn His Lys 
        115                 120                 125             


Glu Val Gln Ala Asn Ala Ser Val Arg Lys Pro Glu Tyr Lys Lys Asp 
    130                 135                 140                 


Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser 
145                 150                 155                 160 


Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His 
                165                 170                 175     


Ser Leu His Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala 
            180                 185                 190         


His Val Ala Thr Ala Ala Ser Trp Asp Ser Gln Val Val Arg Arg Glu 
        195                 200                 205             


Ile Ala Lys Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile 
    210                 215                 220                 


Gln Met Glu Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu 
225                 230                 235                 240 


Asp Pro Cys Asp 
                


