                        SEQUENCE LISTING

<110>  Belouchi, Abdelmajid
       Raelson, John V
       Bradley, Walter E
       Paquin, Bruno
       Fournier, Helene 
       Nguyen-Huu, Quynh
       Croteau, Pascal
       Allard, Rene
       Debrus, Sophie
       Eerdewegh, Paul V
       Little, Randall D
       Keith , Tim
       Segal, Jonathan
 
<120>  Genemap of the Human Genes Associated With Asthma Disease

<130>  GENI-021/01WO

<160>  4417  

<170>  PatentIn version 3.3

<210>  1
<211>  2015
<212>  DNA
<213>  Homosapiens

<400>  1
actgcgaagc ggcttcttca gagcacgggc tggaactggc aggcaccgcg agcccctagc     60

acccgacaag ctgagtgtgc aggacgagtc cccaccacac ccacaccaca gccgctgaat    120

gaggcttcca ggcgtccgct cgcggcccgc agagccccgc cgtgggtccg cccgctgagg    180

cgcccccagc cagtgcgctt acctgccaga ctgcgcgcca tggggcaacc cgggaacggc    240

agcgccttct tgctggcacc caatagaagc catgcgccgg accacgacgt cacgcagcaa    300

agggacgagg tgtgggtggt gggcatgggc atcgtcatgt ctctcatcgt cctggccatc    360

gtgtttggca atgtgctggt catcacagcc attgccaagt tcgagcgtct gcagacggtc    420

accaactact tcatcacttc actggcctgt gctgatctgg tcatgggcct ggcagtggtg    480

ccctttgggg ccgcccatat tcttatgaaa atgtggactt ttggcaactt ctggtgcgag    540

ttttggactt ccattgatgt gctgtgcgtc acggccagca ttgagaccct gtgcgtgatc    600

gcagtggatc gctactttgc cattacttca cctttcaagt accagagcct gctgaccaag    660

aataaggccc gggtgatcat tctgatggtg tggattgtgt caggccttac ctccttcttg    720

cccattcaga tgcactggta ccgggccacc caccaggaag ccatcaactg ctatgccaat    780

gagacctgct gtgacttctt cacgaaccaa gcctatgcca ttgcctcttc catcgtgtcc    840

ttctacgttc ccctggtgat catggtcttc gtctactcca gggtctttca ggaggccaaa    900

aggcagctcc agaagattga caaatctgag ggccgcttcc atgtccagaa ccttagccag    960

gtggagcagg atgggcggac ggggcatgga ctccgcagat cttccaagtt ctgcttgaag   1020

gagcacaaag ccctcaagac gttaggcatc atcatgggca ctttcaccct ctgctggctg   1080

cccttcttca tcgttaacat tgtgcatgtg atccaggata acctcatccg taaggaagtt   1140

tacatcctcc taaattggat aggctatgtc aattctggtt tcaatcccct tatctactgc   1200

cggagcccag atttcaggat tgccttccag gagcttctgt gcctgcgcag gtcttctttg   1260

aaggcctatg ggaatggcta ctccagcaac ggcaacacag gggagcagag tggatatcac   1320

gtggaacagg agaaagaaaa taaactgctg tgtgaagacc tcccaggcac ggaagacttt   1380

gtgggccatc aaggtactgt gcctagcgat aacattgatt cacaagggag gaattgtagt   1440

acaaatgact cactgctgta aagcagtttt tctactttta aagacccccc cccccccaac   1500

agaacactaa acagactatt taacttgagg gtaataaact tagaataaaa ttgtaaaaat   1560

tgtatagaga tatgcagaag gaagggcatc cttctgcctt ttttattttt ttaagctgta   1620

aaaagagaga aaacttattt gagtgattat ttgttatttg tacagttcag ttcctctttg   1680

catggaattt gtaagtttat gtctaaagag ctttagtcct agaggacctg agtctgctat   1740

attttcatga cttttccatg tatctacctc actattcaag tattaggggt aatatattgc   1800

tgctggtaat ttgtatctga aggagatttt ccttcctaca cccttggact tgaggatttt   1860

gagtatctcg gacctttcag ctgtgaacat ggactcttcc cccactcctc ttatttgctc   1920

acacggggta ttttaggcag ggatttgagg agcagcttca gttgttttcc cgagcaaagg   1980

tctaaagttt acagtaaata aaatgtttga ccatg                              2015


<210>  2
<211>  413
<212>  PRT
<213>  Homosapiens

<400>  2

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210>  3
<211>  341
<212>  DNA
<213>  Homosapiens

<400>  3
gctgatggtg gaaggagaat gagtctctga tgcctttgga cttgatgctg gaaagactta     60

agactttggg ggactactgg aaaggagtga cttctcccca gatttttgta tacctgactc    120

tgtttcagca tccgcttccc aaagaatgca gtgtgaagca ggagcttatg tgagaagaaa    180

cgcagggaga cagttcagtc actgcaatct tcatgcccat cagtttcttg tgagaagaaa    240

acaagtggat atacactgtt ccaagcagca tgtgttgaaa agatttgtct tttccccatt    300

taatggtctt ggtacctttc tcaaaaattg accatatatg a                        341


<210>  4
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  4

Met Gln Cys Glu Ala Gly Ala Tyr Val Arg Arg Asn Ala Gly Arg Gln 
1               5                   10                  15      


Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg Arg Lys 
            20                  25                  30          


Gln Val Asp Ile His Cys Ser Lys Gln His Val Leu Lys Arg Phe Val 
        35                  40                  45              


Phe Ser Pro Phe Asn Gly Leu Gly Thr Phe Leu Lys Asn 
    50                  55                  60      


<210>  5
<211>  710
<212>  DNA
<213>  Homosapiens

<400>  5
tctaggactc agaaatatag atgttagtaa gagcaaacag acataacaga taacacatac     60

aaagtgccta ccacatgcta accactgctg caggcacttt ctatagaaga actaatttaa    120

tcatcaccat aaccctatgg ggtagatgat atttttacaa cctccatttt acagatgaag    180

aaactgaagc atagacctgc ttatgtgaga agaaacgcag ggagacagtt cagtcactgc    240

aatcttcatg cccatcagtt tcttgtgaga agaaaacaag aaaacaagga ctgaaatcca    300

cacaggaagg tggcagtgaa ctccacagac ggacctggac gcctcaacac tcctggcctt    360

acctcccttg ctgaacgtct caagtttctc tgcgttcagg actggcaacg cctgcttcct    420

cctctgagct gtcaagtagg aagtccgggc tgctctgcta gaaagagaag tcatgtgcag    480

gagcactgag gcatcccagg tgtgacactc ttccacctag agcattccgt ctctcatcct    540

ctgccatgtg acgctgggct tctttaacaa attaatccca agtgcaagac atttatttct    600

tctgtaccta atgacctgag caatccttct ctgctgaacc tggtagtgtc atctttagaa    660

gtgaagacac aattaacaca tggtcatttc ttcattatat cgttgttact               710


<210>  6
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  6

Met Lys Lys Leu Lys His Arg Pro Ala Tyr Val Arg Arg Asn Ala Gly 
1               5                   10                  15      


Arg Gln Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg 
            20                  25                  30          


Arg Lys Gln Glu Asn Lys Asp 
        35                  


<210>  7
<211>  949
<212>  DNA
<213>  Homosapiens

<400>  7
tctaggactc agaaatatag atgttagtaa gagcaaacag acataacaga taacacatac     60

aaagtgccta ccacatgcta accactgctg caggcacttt ctatagaaga actaatttaa    120

tcatcaccat aaccctatgg ggtagatgat atttttacaa cctccatttt acagatgaag    180

aaactgaagc atagacctgc ttatgtgaga agaaacgcag ggagacagtt cagtcactgc    240

aatcttcatg cccatcagtt tcttgtgaga agaaaacaag actggcaacg cctgcttcct    300

cctctgagct gtcaagtagg aagtccgggc tgctctgcta gaaagagaag tcatgtgcag    360

gagcactgag gcatcccagg tgtgacactc ttccacctag agcattccgt ctctcatcct    420

ctgccatgta gcaaactgct atgcatcctt cagctgcaag ggattgaatg ctatcaacaa    480

ccatacaagt ggagaagcag atgcttccct agctgagcct caggcttttt gatggaattg    540

ctacaacttg gtgcatgcct gctcctaaaa gaaatactca ggaattgtct cataaagtcc    600

tcacctactg gcaaaaacaa gatgttctac tcccaggttg actttttcaa gccccaagat    660

gttgagtcag ccattctcca aggatctcga tttcctttta atggaaaata acattaaaca    720

ccaaatataa gcctcgctgt cccacatgcg tattggggac aagatgaaac ctgcttccag    780

gctactttgg cagcagaact gaaaaaggct ttttttccag atatatgatt tctcatcgac    840

agggttgcac agccctcttt attgttcgtg taaatgacac ccttggatct gaacaataca    900

caccaggaca attgtgtgca acagttctac aaactgatat ttctaatta                949


<210>  8
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  8

Met Lys Lys Leu Lys His Arg Pro Ala Tyr Val Arg Arg Asn Ala Gly 
1               5                   10                  15      


Arg Gln Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg 
            20                  25                  30          


Arg Lys Gln Asp Trp Gln Arg Leu Leu Pro Pro Leu Ser Cys Gln Val 
        35                  40                  45              


Gly Ser Pro Gly Cys Ser Ala Arg Lys Arg Ser His Val Gln Glu His 
    50                  55                  60                  


<210>  9
<211>  550
<212>  DNA
<213>  Homosapiens

<400>  9
tctaggactc agaaatatag atgttagtaa gagcaaacag acataacaga taacacatac     60

aaagtgccta ccacatgcta accactgctg caggcacttt ctatagaaga actaatttaa    120

tcatcaccat aaccctatgg ggtagatgat atttttacaa cctccatttt acagatgaag    180

aaactgaagc atagacctgc ttatgtgaga agaaacgcag ggagacagtt cagtcactgc    240

aatcttcatg cccatcagtt tcttgtgaga agaaaacaag actggcaacg cctgcttcct    300

cctctgagct gtcaagtagg aagtccgggc tgctctgcta gaaagagaag tcatgtgcag    360

gagcactgag gcatcccagg tgtgacactc ttccacctag agcattccgt ctctcatcct    420

ctgccatgtg ccatgttttg aaccactaga ttagagggtc aagcaatttc ttggaatttt    480

actctgaatt ctacgtagac cattttcatg tgtatacctc ctctgagtca ccctcaggta    540

gggacatttt                                                           550


<210>  10
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  10

Met Lys Lys Leu Lys His Arg Pro Ala Tyr Val Arg Arg Asn Ala Gly 
1               5                   10                  15      


Arg Gln Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg 
            20                  25                  30          


Arg Lys Gln Asp Trp Gln Arg Leu Leu Pro Pro Leu Ser Cys Gln Val 
        35                  40                  45              


Gly Ser Pro Gly Cys Ser Ala Arg Lys Arg Ser His Val Gln Glu His 
    50                  55                  60                  


<210>  11
<211>  369
<212>  DNA
<213>  Homosapiens

<400>  11
gctgatggtg gaaggagaat gagtctctga tgcctttgga cttgatgctg gaaagactta     60

agactttggg ggactactgg aaaggagtga cttctcccca gatttttgta tacctgactc    120

tgtttcagca tccgcttccc aaagaatgca gtgtgaagca ggagcttatg tgagaagaaa    180

cgcagggaga cagttcagtc actgcaatct tcatgcccat cagtttcttg tgagaagaaa    240

acaagtttag gaaaacttcc tacaccttct ttgttgggat gttctctgga ctaatgactc    300

caggcgagac caccgttgat catgaactca ctttgaaaca gaagctgggt tggtaagact    360

ggagctact                                                            369


<210>  12
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  12

Met Gln Cys Glu Ala Gly Ala Tyr Val Arg Arg Asn Ala Gly Arg Gln 
1               5                   10                  15      


Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg Arg Lys 
            20                  25                  30          


Gln Val 
        


<210>  13
<211>  799
<212>  DNA
<213>  Homosapiens

<400>  13
tctaggactc agaaatatag atgttagtaa gagcaaacag acataacaga taacacatac     60

aaagtgccta ccacatgcta accactgctg caggcacttt ctatagaaga actaatttaa    120

tcatcaccat aaccctatgg ggtagatgat atttttacaa cctccatttt acagatgaag    180

aaactgaagc atagacctgc ttatgtgaga agaaacgcag ggagacagtt cagtcactgc    240

aatcttcatg cccatcagtt tcttgtgaga agaaaacaaa gcaaactgct atgcatcctt    300

cagctgcaag ggattgaatg ctatcaacaa ccatacaagt ggagaagcag atgcttccct    360

agctgagcct caggcttttt gatggaattg ctacaacttg gtgcatgcct gctcctaaaa    420

gaaatactca ggaattgtct cataaagtcc tcacctactg gcaaaaacaa gatgttctac    480

tcccaggttg actttttcaa gccccaagat gttgagtcag ccattctcca aggatctcga    540

tttcctttta atggaaaata acattaaaca ccaaatataa gcctcgctgt cccacatgcg    600

tattggggac aagatgaaac ctgcttccag gctactttgg cagcagaact gaaaaaggct    660

ttttttccag atatatgatt tctcatcgac agggttgcac agccctcttt attgttcgtg    720

taaatgacac ccttggatct gaacaataca caccaggaca attgtgtgca acagttctac    780

aaactgatat ttctaatta                                                 799


<210>  14
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  14

Met Lys Lys Leu Lys His Arg Pro Ala Tyr Val Arg Arg Asn Ala Gly 
1               5                   10                  15      


Arg Gln Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg 
            20                  25                  30          


Arg Lys Gln Ser Lys Leu Leu Cys Ile Leu Gln Leu Gln Gly Ile Glu 
        35                  40                  45              


Cys Tyr Gln Gln Pro Tyr Lys Trp Arg Ser Arg Cys Phe Pro Ser 
    50                  55                  60              


<210>  15
<211>  834
<212>  DNA
<213>  Homosapiens

<400>  15
gctgatggtg gaaggagaat gagtctctga tgcctttgga cttgatgctg gaaagactta     60

agactttggg ggactactgg aaagcttatg tgagaagaaa cgcagggaga cagttcagtc    120

actgcaatct tcatgcccat cagtttcttg tgagaagaaa acaagactgg caacgcctgc    180

ttcctcctct gagctgtcaa gtaggaagtc cgggctgctc tgctagaaag agaagtcatg    240

tgcaggagca ctgaggcatc ccaggtgtga cactcttcca cctagagcat tccgtctctc    300

atcctctgcc atgtagcaaa ctgctatgca tccttcagct gcaagggatt gaatgctatc    360

aacaaccata caagtggaga agcagatgct tccctagctg agcctcaggc tttttgatgg    420

aattgctaca acttggtgca tgcctgctcc taaaagaaat actcaggaat tgtctcataa    480

agtcctcacc tactggcaaa aacaagatgt tctactccca ggttgacttt ttcaagcccc    540

aagatgttga gtcagccatt ctccaaggat ctcgatttcc ttttaatgga aaataacatt    600

aaacaccaaa tataagcctc gctgtcccac atgcgtattg gggacaagat gaaacctgct    660

tccaggctac tttggcagca gaactgaaaa aggctttttt tccagatata tgatttctca    720

tcgacagggt tgcacagccc tctttattgt tcgtgtaaat gacacccttg gatctgaaca    780

atacacacca ggacaattgt gtgcaacagt tctacaaact gatatttcta atta          834


<210>  16
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  16

Met Pro Leu Asp Leu Met Leu Glu Arg Leu Lys Thr Leu Gly Asp Tyr 
1               5                   10                  15      


Trp Lys Ala Tyr Val Arg Arg Asn Ala Gly Arg Gln Phe Ser His Cys 
            20                  25                  30          


Asn Leu His Ala His Gln Phe Leu Val Arg Arg Lys Gln Asp Trp Gln 
        35                  40                  45              


Arg Leu Leu Pro Pro Leu Ser Cys Gln Val Gly Ser Pro Gly Cys Ser 
    50                  55                  60                  


Ala Arg Lys Arg Ser His Val Gln Glu His 
65                  70                  


<210>  17
<211>  376
<212>  DNA
<213>  Homosapiens

<400>  17
tctaggactc agaaatatag atgttagtaa gagcaaacag acataacaga taacacatac     60

aaagtgccta ccacatgcta accactgctg caggcacttt ctatagaaga actaatttaa    120

tcatcaccat aaccctatgg ggtagatgat atttttacaa cctccatttt acagatgaag    180

aaactgaagc atagacctgc ttatgtgaga agaaacgcag ggagacagtt cagtcactgc    240

aatcttcatg cccatcagtt tcttgtgaga agaaaacaag tggatataca ctgttccaag    300

cagcatgtgt tgaaaagatt tgtcttttcc ccatttaatg gtcttggtac ctttctcaaa    360

aattgaccat atatga                                                    376


<210>  18
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  18

Met Lys Lys Leu Lys His Arg Pro Ala Tyr Val Arg Arg Asn Ala Gly 
1               5                   10                  15      


Arg Gln Phe Ser His Cys Asn Leu His Ala His Gln Phe Leu Val Arg 
            20                  25                  30          


Arg Lys Gln Val Asp Ile His Cys Ser Lys Gln His Val Leu Lys Arg 
        35                  40                  45              


Phe Val Phe Ser Pro Phe Asn Gly Leu Gly Thr Phe Leu Lys Asn 
    50                  55                  60              


<210>  19
<211>  1410
<212>  DNA
<213>  Homosapiens

<400>  19
gggctcaggg agggctctgt gcctccgttc agcagagctg cagctgctgc ccagctctca     60

ggaggcaagc tggactccct cactcagctg caggagcaag gacagtgagg ctcaaccccg    120

cctgagccat gccagccaac ttcacagagg gcagcttcga ttccagtggg accgggcaga    180

cgctggattc ttccccagtg gcttgcactg aaacagtgac ttttactgaa gtggtggaag    240

gaaaggaatg gggttccttc tactactcct ttaagactga gcaattgata actctgtggg    300

tcctctttgt ttttaccatt gttggaaact ccgttgtgct tttttccaca tggaggagaa    360

agaagaagtc aagaatgacc ttctttgtga ctcagctggc catcacagat tctttcacag    420

gactggtcaa catcttgaca gatattaatt ggcgattcac tggagacttc acggcacctg    480

acctggtttg ccgagtggtc cgctatttgc aggttgtgct gctctacgcc tctacctacg    540

tcctggtgtc cctcagcata gacagatacc atgccatcgt ctaccccatg aagttccttc    600

aaggagaaaa gcaagccagg gtcctcattg tgatcgcctg gagcctgtct tttctgttct    660

ccattcccac cctgatcata tttgggaaga ggacactgtc caacggtgaa gtgcagtgct    720

gggccctgtg gcctgacgac tcctactgga ccccatacat gaccatcgtg gccttcctgg    780

tgtacttcat ccctctgaca atcatcagca tcatgtatgg cattgtgatc cgaactattt    840

ggattaaaag caaaacctac gaaacagtga tttccaactg ctcagatggg aaactgtgca    900

gcagctataa ccgaggactc atctcaaagg caaaaatcaa ggctatcaag tatagcatca    960

tcatcattct tgccttcatc tgctgttgga gtccatactt cctgtttgac attttggaca   1020

atttcaacct ccttccagac acccaggagc gtttctatgc ctctgtgatc attcagaacc   1080

tgccagcatt gaatagtgcc atcaaccccc tcatctactg tgtcttcagc agctccatct   1140

ctttcccctg cagggtcatc cgtctccgtc agctccagga ggctgcgcta atgctctgcc   1200

ctcaacgaga gaactggaag ggtacttggc caggtgtacc ttcctgggct cttccaaggt   1260

gacagctctc accctgtgct gcaggtggcc ctgtgcctgg tgccacttct cactgcttac   1320

cagggcacaa ggacaccagt ggttcccaaa atgggtcaca gcaggatggc ctgcatcaga   1380

ttcaccaggg agggctataa gaaggcagac                                    1410


<210>  20
<211>  377
<212>  PRT
<213>  Homosapiens

<400>  20

Met Pro Ala Asn Phe Thr Glu Gly Ser Phe Asp Ser Ser Gly Thr Gly 
1               5                   10                  15      


Gln Thr Leu Asp Ser Ser Pro Val Ala Cys Thr Glu Thr Val Thr Phe 
            20                  25                  30          


Thr Glu Val Val Glu Gly Lys Glu Trp Gly Ser Phe Tyr Tyr Ser Phe 
        35                  40                  45              


Lys Thr Glu Gln Leu Ile Thr Leu Trp Val Leu Phe Val Phe Thr Ile 
    50                  55                  60                  


Val Gly Asn Ser Val Val Leu Phe Ser Thr Trp Arg Arg Lys Lys Lys 
65                  70                  75                  80  


Ser Arg Met Thr Phe Phe Val Thr Gln Leu Ala Ile Thr Asp Ser Phe 
                85                  90                  95      


Thr Gly Leu Val Asn Ile Leu Thr Asp Ile Asn Trp Arg Phe Thr Gly 
            100                 105                 110         


Asp Phe Thr Ala Pro Asp Leu Val Cys Arg Val Val Arg Tyr Leu Gln 
        115                 120                 125             


Val Val Leu Leu Tyr Ala Ser Thr Tyr Val Leu Val Ser Leu Ser Ile 
    130                 135                 140                 


Asp Arg Tyr His Ala Ile Val Tyr Pro Met Lys Phe Leu Gln Gly Glu 
145                 150                 155                 160 


Lys Gln Ala Arg Val Leu Ile Val Ile Ala Trp Ser Leu Ser Phe Leu 
                165                 170                 175     


Phe Ser Ile Pro Thr Leu Ile Ile Phe Gly Lys Arg Thr Leu Ser Asn 
            180                 185                 190         


Gly Glu Val Gln Cys Trp Ala Leu Trp Pro Asp Asp Ser Tyr Trp Thr 
        195                 200                 205             


Pro Tyr Met Thr Ile Val Ala Phe Leu Val Tyr Phe Ile Pro Leu Thr 
    210                 215                 220                 


Ile Ile Ser Ile Met Tyr Gly Ile Val Ile Arg Thr Ile Trp Ile Lys 
225                 230                 235                 240 


Ser Lys Thr Tyr Glu Thr Val Ile Ser Asn Cys Ser Asp Gly Lys Leu 
                245                 250                 255     


Cys Ser Ser Tyr Asn Arg Gly Leu Ile Ser Lys Ala Lys Ile Lys Ala 
            260                 265                 270         


Ile Lys Tyr Ser Ile Ile Ile Ile Leu Ala Phe Ile Cys Cys Trp Ser 
        275                 280                 285             


Pro Tyr Phe Leu Phe Asp Ile Leu Asp Asn Phe Asn Leu Leu Pro Asp 
    290                 295                 300                 


Thr Gln Glu Arg Phe Tyr Ala Ser Val Ile Ile Gln Asn Leu Pro Ala 
305                 310                 315                 320 


Leu Asn Ser Ala Ile Asn Pro Leu Ile Tyr Cys Val Phe Ser Ser Ser 
                325                 330                 335     


Ile Ser Phe Pro Cys Arg Val Ile Arg Leu Arg Gln Leu Gln Glu Ala 
            340                 345                 350         


Ala Leu Met Leu Cys Pro Gln Arg Glu Asn Trp Lys Gly Thr Trp Pro 
        355                 360                 365             


Gly Val Pro Ser Trp Ala Leu Pro Arg 
    370                 375         


<210>  21
<211>  1567
<212>  DNA
<213>  Homosapiens

<400>  21
gggctcaggg agggctctgt gcctccgttc agcagagctg cagctgctgc ccagctctca     60

ggaggcaagc tggactccct cactcagctg caggagcaag gacagtgagg ctcaaccccg    120

cctgagccat gccagccaac ttcacagagg gcagcttcga ttccagtggg accgggcaga    180

cgctggattc ttccccagtg gcttgcactg aaacagtgac ttttactgaa gtggtggaag    240

gaaaggaatg gggttccttc tactactcct ttaagactga gcaattgata actctgtggg    300

tcctctttgt ttttaccatt gttggaaact ccgttgtgct tttttccaca tggaggagaa    360

agaagaagtc aagaatgacc ttctttgtga ctcagctggc catcacagat tctttcacag    420

gactggtcaa catcttgaca gatattaatt ggcgattcac tggagacttc acggcacctg    480

acctggtttg ccgagtggtc cgctatttgc aggttgtgct gctctacgcc tctacctacg    540

tcctggtgtc cctcagcata gacagatacc atgccatcgt ctaccccatg aagttccttc    600

aaggagaaaa gcaagccagg gtcctcattg tgatcgcctg gagcctgtct tttctgttct    660

ccattcccac cctgatcata tttgggaaga ggacactgtc caacggtgaa gtgcagtgct    720

gggccctgtg gcctgacgac tcctactgga ccccatacat gaccatcgtg gccttcctgg    780

tgtacttcat ccctctgaca atcatcagca tcatgtatgg cattgtgatc cgaactattt    840

ggattaaaag caaaacctac gaaacagtga tttccaactg ctcagatggg aaactgtgca    900

gcagctataa ccgaggactc atctcaaagg caaaaatcaa ggctatcaag tatagcatca    960

tcatcattct tgccttcatc tgctgttgga gtccatactt cctgtttgac attttggaca   1020

atttcaacct ccttccagac acccaggagc gtttctatgc ctctgtgatc attcagaacc   1080

tgccagcatt gaatagtgcc atcaaccccc tcatctactg tgtcttcagc agctccatct   1140

ctttcccctg cagggagcaa agatcacagg attccagaat gacgttccgg gagagaactg   1200

agaggcatga gatgcagatt ctgtccaagc cagaattcat ctagacccta gggcagtgcc   1260

agtgctaggc tgagcaccat cagctctccc aggtccttgt cacctgcttg ggcacgtgca   1320

tggaacccga gccaacttca ccccaccctc gtcattacct gggagatgca caagacaaat   1380

gttctaatga ctgcatgcac tgcttaagta ttggccaaca cgaactcccc agttattcat   1440

gccagccagg aaggaaacgc cttccttccc caccattccc agccctcctt cccactggcc   1500

agcacctgaa cccagtgaac acaggcatta gtggtccagg gtcctggctt ggagccagtg   1560

agtagac                                                             1567


<210>  22
<211>  371
<212>  PRT
<213>  Homosapiens

<400>  22

Met Pro Ala Asn Phe Thr Glu Gly Ser Phe Asp Ser Ser Gly Thr Gly 
1               5                   10                  15      


Gln Thr Leu Asp Ser Ser Pro Val Ala Cys Thr Glu Thr Val Thr Phe 
            20                  25                  30          


Thr Glu Val Val Glu Gly Lys Glu Trp Gly Ser Phe Tyr Tyr Ser Phe 
        35                  40                  45              


Lys Thr Glu Gln Leu Ile Thr Leu Trp Val Leu Phe Val Phe Thr Ile 
    50                  55                  60                  


Val Gly Asn Ser Val Val Leu Phe Ser Thr Trp Arg Arg Lys Lys Lys 
65                  70                  75                  80  


Ser Arg Met Thr Phe Phe Val Thr Gln Leu Ala Ile Thr Asp Ser Phe 
                85                  90                  95      


Thr Gly Leu Val Asn Ile Leu Thr Asp Ile Asn Trp Arg Phe Thr Gly 
            100                 105                 110         


Asp Phe Thr Ala Pro Asp Leu Val Cys Arg Val Val Arg Tyr Leu Gln 
        115                 120                 125             


Val Val Leu Leu Tyr Ala Ser Thr Tyr Val Leu Val Ser Leu Ser Ile 
    130                 135                 140                 


Asp Arg Tyr His Ala Ile Val Tyr Pro Met Lys Phe Leu Gln Gly Glu 
145                 150                 155                 160 


Lys Gln Ala Arg Val Leu Ile Val Ile Ala Trp Ser Leu Ser Phe Leu 
                165                 170                 175     


Phe Ser Ile Pro Thr Leu Ile Ile Phe Gly Lys Arg Thr Leu Ser Asn 
            180                 185                 190         


Gly Glu Val Gln Cys Trp Ala Leu Trp Pro Asp Asp Ser Tyr Trp Thr 
        195                 200                 205             


Pro Tyr Met Thr Ile Val Ala Phe Leu Val Tyr Phe Ile Pro Leu Thr 
    210                 215                 220                 


Ile Ile Ser Ile Met Tyr Gly Ile Val Ile Arg Thr Ile Trp Ile Lys 
225                 230                 235                 240 


Ser Lys Thr Tyr Glu Thr Val Ile Ser Asn Cys Ser Asp Gly Lys Leu 
                245                 250                 255     


Cys Ser Ser Tyr Asn Arg Gly Leu Ile Ser Lys Ala Lys Ile Lys Ala 
            260                 265                 270         


Ile Lys Tyr Ser Ile Ile Ile Ile Leu Ala Phe Ile Cys Cys Trp Ser 
        275                 280                 285             


Pro Tyr Phe Leu Phe Asp Ile Leu Asp Asn Phe Asn Leu Leu Pro Asp 
    290                 295                 300                 


Thr Gln Glu Arg Phe Tyr Ala Ser Val Ile Ile Gln Asn Leu Pro Ala 
305                 310                 315                 320 


Leu Asn Ser Ala Ile Asn Pro Leu Ile Tyr Cys Val Phe Ser Ser Ser 
                325                 330                 335     


Ile Ser Phe Pro Cys Arg Glu Gln Arg Ser Gln Asp Ser Arg Met Thr 
            340                 345                 350         


Phe Arg Glu Arg Thr Glu Arg His Glu Met Gln Ile Leu Ser Lys Pro 
        355                 360                 365             


Glu Phe Ile 
    370     


<210>  23
<211>  3723
<212>  DNA
<213>  Homosapiens

<400>  23
aacccatttc aactgcctat tcagagcatg cagtaagagg aaatccacca agtctcaata     60

taataatatt ctttattcct ggacagctcg gttaatgaaa aaatggacac agaaagtaat    120

aggagagcaa atcttgctct cccacaggag ccttccagtg tgcctgcatt tgaagtcttg    180

gaaatatctc cccaggaagt atcttcaggc agactattga agtcggcctc atccccacca    240

ctgcatacat ggctgacagt tttgaaaaaa gagcaggagt tcctgggggt aacacaaatt    300

ctgactgcta tgatatgcct ttgttttgga acagttgtct gctctgtact tgatatttca    360

cacattgagg gagacatttt ttcatcattt aaagcaggtt atccattctg gggagccata    420

tttttttcta tttctggaat gttgtcaatt atatctgaaa ggagaaatgc aacatatctg    480

gtgagaggaa gcctgggagc aaacactgcc agcagcatag ctgggggaac gggaattacc    540

atcctgatca tcaacctgaa gaagagcttg gcctatatcc acatccacag ttgccagaaa    600

ttttttgaga ccaagtgctt tatggcttcc ttttccactg aaattgtagt gatgatgctg    660

tttctcacca ttctgggact tggtagtgct gtgtcactca caatctgtgg agctggggaa    720

gaactcaaag gaaacaaggt tccagaggat cgtgtttatg aagaattaaa catatattca    780

gctacttaca gtgagttgga agacccaggg gaaatgtctc ctcccattga tttataagaa    840

tcacgtgtcc agaacactct gattcacagc caaggatcca gaaggccaag gtcttgttaa    900

ggggctactg gaaaaatttc tattctctcc acagcctgct ggttttacat tagatttatt    960

cgcctgataa gaatattttg tttctgctgc ttctgtccac cttaatattc tccttctatt   1020

tgtagatatg atagactcct atttttcttg ttttatatta tgaccacaca catctctgct   1080

ggaaagtcaa catgtagtaa gcaagattta actgtttgat tataactgtg caaatacaga   1140

aaaaaagaag gctggctgaa agttgagtta aactttgaca gtttgataat atttggttct   1200

tagggttttt ttttttttta gcattcttaa tagttacagt tgggcatgat ttgtaccatc   1260

cacccatacc cacacagtca cagtcacaca cacatatgta ttacttacac tatatataac   1320

ttcctatgca aatattttac caccagtcaa taatacattt ttgccaagac atgaagtttt   1380

ataaagatct gtataattgc ctgaatcacc agcacattca ctgacatgat attatttgca   1440

gattgacaag taggaagtgg ggaattttat taagttactc gttgtctggg gaggtaaata   1500

ggttaaaaac agggaaatta taagtgcaga gattaacatt tcacaaatgt ttagtgaaac   1560

atttgtgaaa aaagaagact aaattaagac ctgagctgaa ataaagtgag tggaaatgga   1620

aataatggtt atatctaaaa catgtagaaa aagagtaact ggtagatttt gttaacaaat   1680

taaagaataa agttagacaa gcaactggtt gactaataca ttaagcgttt gagtctaaga   1740

tgaaaggaga acactggtta tgttgataga atgataaaaa gggtcgggcg cggaggctca   1800

cgcctgtaat cccagccctt tgggaggccg aggtgggcag atcacgaagt cagtagtttg   1860

agaccagcct ggccaacata gtgaaacccc gtctctacta aaaatacaaa aaaaaaatta   1920

gctgggtgtg gtggcagtca cctgtagtcc cagctacttg ggaggatgag gcaggagaat   1980

cgcttgaacc tgggaggcgg aggttgcagt gagccgagat cgcaccagtg cactccagcc   2040

ttggtgacaa tgggagactc catctcaaaa aaaaaaaaaa aaaaaaaaag ataaaaagtc   2100

agaaatctga aaagtggagg aagagtacaa atagacctaa attaagctca tttttaggct   2160

ttgattttgg ggagacaaag ggaaatgcag ccatagaggg cctgatgaca tccaatacag   2220

agttctggta aagataaaat ttgatacagg tttggtgtca ttataagaga aatcattatt   2280

aaatgaagca agttaacact ctaagagaat tattttgaga tagaagtgaa gctaagctaa   2340

acttcacatg cctataattg gagggaaaaa ctaaggataa aatctagcct agaagataca   2400

ataattagtc ataaacatgc attgtgaaac tgtagagagc aggtagccca aaatagagaa   2460

agattagata aagagaaaat aagtatccat cagagacagt atctctaggc ttgggcaaga   2520

gaaaagtcca cagtgataag caactccacc taaggcatga atatgcggca gagaaaacag   2580

caatagtgaa tgaatgcaaa aggtgctgag aaattccaca catgagtatt gtgatgagta   2640

aatgaataaa acatttgcaa agacctttag agaaagagaa tgggagcata tgtgagaaat   2700

aagatagttg attatgaata gaaggtagtg aagaaaagca agctaagaaa aaattctgtt   2760

tataaaagaa ggaaaagata gtttatgttt ttagcctaag tataagagtc ctacagatgg   2820

actgaaaaaa atcagtctga gagtattagt cacaattaat gaaataatta cattttatgt   2880

attgaggatg ccaagattaa aaggtgacag gtagatgtta atttccctag attgtgaaag   2940

tgatcacgac aatcacacaa caaataatta agtgacttgg tatgctttat ttaattgtag   3000

ggcctgaggt tttccattct catttttcta aaatacaatt ttgtttctcc aaatttgaca   3060

gcagaataaa aaccctaccc tttcactgtg tatcatgcta agctgcatct ctactcttga   3120

tcatctgtag gtattaatca catcacttcc atggcatgga tgttcacata cagactctta   3180

accctggttt accaggacct ctaggagtgg atccaatcta tatctttaca gttgtatagt   3240

atatgatatc tcttttattt cactcaattt atattttcat cattgactac atatttctta   3300

tacacaacac acaatttatg aattttttct caagatcatt ctgagagttg ccccacccta   3360

cctgcctttt atagtatgcc cacctcaggc agacacagag cacaatgctg gggttctctt   3420

cacactatca ctgccccaaa ttgtctttct aaatttcaac ttcaatgtca tcttctccat   3480

gaagaccact gaatgaacac cttttcatcc agccttaatt tcttgctcca taactactct   3540

atcccacgat gcagtattgt atcattaatt attagtgtgc ttgtgacctc cttatgtatt   3600

ctcaattacc tgtatttgtg caataaattg gaataatgta acttgatttc ttatctgtgt   3660

ttgtgttggc atgcaagatt taggtactta tcaaagataa tggggaatta aggcatcaat   3720

aaa                                                                 3723


<210>  24
<211>  244
<212>  PRT
<213>  Homosapiens

<400>  24

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  25
<211>  1323
<212>  DNA
<213>  Homosapiens

<400>  25
cacaaaggca ccaaaccaca aaacgtcaca cgtaaacatc atacgtggca accacaagcc     60

aatcagttgg atatttcatt cattggtata catatggact gtaaggtgtc tttcaggttg    120

cagaaaagat ggaaaaaagg acatgtgcac tctgccccaa agatgtcgaa tataatgtcc    180

tgtactttgc acaatcagag aatatagctg ctcatgagaa ttgtttgctg tattcttcag    240

gacttgtgga atgtgaggat caggatccac ttaatcctga tagaagtttt gatgtggaat    300

cagtaaagaa agaaatccag agaggaagga agttgaaatg caaattttgt cataaaagag    360

gagccaccgt gggatgtgat ttaaaaaact gtaacaagaa ttaccacttt ttctgtgcca    420

agaaggacga cgcagttcca cagtctgatg gagttcgagg aatttataaa ctgctttgcc    480

agcaacatgc tcaattcccg atcatcgctc aaagtgctaa attttcagga gtgaaaagaa    540

aaagaggaag gaagaaaccc ctctcaggca atcatgtaca gccacccgaa acaatgaaat    600

gtaatacatt cataagacaa gtgaaagaag agcatggcag acacacagat gcaactgtga    660

aagttccttt tcttaagaaa tgcaagggaa gcaggacttc ttaattactt acttgaagaa    720

atattagaca aagttcattc aattccagaa aaactcatgg atgagactta cttcagaatc    780

agactatgaa gaaatcggga gtgcactttt tgactgtaga ttgttcgaag acacatttgt    840

aaattttcaa gcagcaatag agaaaaaaat tcatgcatct caacaaaggt ggcagcagtt    900

gaaggaagag attgagctac ttcaggactt aaaacaaacc ttgtgctctt ttcaagaaaa    960

tagagatctt atgtcaagtt ctacatcaat atcatccctg tcttattagg gattaccatt   1020

tcctaagcca agagtcatgt caaattgcaa tcaggctcaa aaccagagac caggctgtga   1080

aatccacaca tctttagaac tagtcgtctc ctcttggcct cagcagctct tccctgttct   1140

tactggttga cattttgatc actctttgca cactcttgtg ttttttgctc actgtcacac   1200

tcccagcacc tagtatgctc agtaaatgtt tgtggaataa gtgcataaaa tgttcttaac   1260

ctttgattct acttacagcc catgatagcc tcttagatat aataaatttg gattatacta   1320

aaa                                                                 1323


<210>  26
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  26

Met Glu Lys Arg Thr Cys Ala Leu Cys Pro Lys Asp Val Glu Tyr Asn 
1               5                   10                  15      


Val Leu Tyr Phe Ala Gln Ser Glu Asn Ile Ala Ala His Glu Asn Cys 
            20                  25                  30          


Leu Leu Tyr Ser Ser Gly Leu Val Glu Cys Glu Asp Gln Asp Pro Leu 
        35                  40                  45              


Asn Pro Asp Arg Ser Phe Asp Val Glu Ser Val Lys Lys Glu Ile Gln 
    50                  55                  60                  


Arg Gly Arg Lys Leu Lys Cys Lys Phe Cys His Lys Arg Gly Ala Thr 
65                  70                  75                  80  


Val Gly Cys Asp Leu Lys Asn Cys Asn Lys Asn Tyr His Phe Phe Cys 
                85                  90                  95      


Ala Lys Lys Asp Asp Ala Val Pro Gln Ser Asp Gly Val Arg Gly Ile 
            100                 105                 110         


Tyr Lys Leu Leu Cys Gln Gln His Ala Gln Phe Pro Ile Ile Ala Gln 
        115                 120                 125             


Ser Ala Lys Phe Ser Gly Val Lys Arg Lys Arg Gly Arg Lys Lys Pro 
    130                 135                 140                 


Leu Ser Gly Asn His Val Gln Pro Pro Glu Thr Met Lys Cys Asn Thr 
145                 150                 155                 160 


Phe Ile Arg Gln Val Lys Glu Glu His Gly Arg His Thr Asp Ala Thr 
                165                 170                 175     


Val Lys Val Pro Phe Leu Lys Lys Cys Lys Gly Ser Arg Thr Ser 
            180                 185                 190     


<210>  27
<211>  3516
<212>  DNA
<213>  Homosapiens

<400>  27
gctgcaccgg gcacgggtcg gccgcaatcc agcctgggcg gagccggagt tgcgagccgc     60

tgcctagagg ccgaggagct cacagctatg ggctggaggc cccggagagc tcgggggacc    120

ccgttgctgc tgctgctact actgctgctg ctctggccag tgccaggcgc cggggtgctt    180

caaggacata tccctgggca gccagtcacc ccgcactggg tcctggatgg acaaccctgg    240

cgcaccgtca gcctggagga gccggtctcg aagccagaca tggggctggt ggccctggag    300

gctgaaggcc aggagctcct gcttgagctg gagaagaacc acaggctgct ggccccagga    360

tacatagaaa cccactacgg cccagatggg cagccagtgg tgctggcccc caaccacacg    420

gatcattgcc actaccaagg gcgagtaagg ggcttccccg actcctgggt agtcctctgc    480

acctgctctg ggatgagtgg cctgatcacc ctcagcagga atgccagcta ttatctgcgt    540

ccctggccac cccggggctc caaggacttc tcaacccacg agatctttcg gatggagcag    600

ctgctcacct ggaaaggaac ctgtggccac agggatcctg ggaacaaagc gggcatgacc    660

agccttcctg gtggtcccca gagcaggggc aggcgagaag cgcgcaggac ccggaagtac    720

ctggaactgt acattgtggc agaccacacc ctgttcttga ctcggcaccg aaacttgaac    780

cacaccaaac agcgtctcct ggaagtcgcc aactacgtgg accagcttct caggactctg    840

gacattcagg tggcgctgac cggcctggag gtgtggaccg agcgggaccg cagccgcgtc    900

acgcaggacg ccaacgccac gctctgggcc ttcctgcagt ggcgccgggg gctgtgggcg    960

cagcggcccc acgactccgc gcagctgctc acgggccgcg ccttccaggg cgccacagtg   1020

ggcctggcgc ccgtcgaggg catgtgccgc gccgagagct cgggaggcgt gagcacggac   1080

cactcggagc tccccatcgg cgccgcagcc accatggccc atgagatcgg ccacagcctc   1140

ggcctcagcc acgaccccga cggctgctgc gtggaggctg cggccgagtc cggaggctgc   1200

gtcatggctg cggccaccgg gcacccgttt ccgcgcgtgt tcagcgcctg cagccgccgc   1260

cagctgcgcg ccttcttccg caaggggggc ggcgcttgcc tctccaatgc cccggacccc   1320

ggactcccgg tgccgccggc gctctgcggg aacggcttcg tggaagcggg cgaggagtgt   1380

gactgcggcc ctggccagga gtgccgcgac ctctgctgct ttgctcacaa ctgctcgctg   1440

cgcccggggg cccagtgcgc ccacggggac tgctgcgtgc gctgcctgct gaagccggct   1500

ggagcgctgt gccgccaggc catgggtgac tgtgacctcc ctgagttttg cacgggcacc   1560

tcctcccact gtcccccaga cgtttaccta ctggacggct caccctgtgc caggggcagt   1620

ggctactgct gggatggcgc atgtcccacg ctggagcagc agtgccagca gctctggggg   1680

cctggctccc acccagctcc cgaggcctgt ttccaggtgg tgaactctgc gggagatgct   1740

catggaaact gcggccagga cagcgagggc cacttcctgc cctgtgcagg gagggatgcc   1800

ctgtgtggga agctgcagtg ccagggtgga aagcccagcc tgctcgcacc gcacatggtg   1860

ccagtggact ctaccgttca cctagatggc caggaagtga cttgtcgggg agccttggca   1920

ctccccagtg cccagctgga cctgcttggc ctgggcctgg tagagccagg cacccagtgt   1980

ggacctagaa tggtttgcaa tagcaaccat aactgccact gtgctccagg ctgggctcca   2040

cccttctgtg acaagccagg ctttggtggc agcatggaca gtggccctgt gcaggctgaa   2100

aaccatgaca ccttcctgct ggccatgctc ctcagcgtcc tgctgcctct gctcccaggg   2160

gccggcctgg cctggtgttg ctaccgactc ccaggagccc atctgcagcg atgcagctgg   2220

ggctgcagaa gggaccctgc gtgcagtggc cccaaagatg gcccacacag ggaccacccc   2280

ctgggcggcg ttcaccccat ggagttgggc cccacagcca ctggacagcc ctggcccctg   2340

gaccctgaga actctcatga gcccagcagc caccctgaga agcctctgcc agcagtctcg   2400

cctgaccccc aagcagatca agtccagatg ccaagatcct gcctctggtg agaggtagct   2460

cctaaaatga acagatttaa agacaggtgg ccactgacag ccactccagg aacttgaact   2520

gcaggggcag agccagtgaa tcaccggacc tccagcacct gcaggcagct tggaagtttc   2580

ttccccgagt ggagcttcga cccacccact ccaggaaccc agagccacat tagaagttcc   2640

tgagggctgg agaacactgc tgggcacact ctccagctca ataaaccatc agtcccagaa   2700

gcaaaggtca cacagcccct gacctccctc accagtggag gctgggtagt gctggccatc   2760

ccaaaagggc tctgtcctgg gagtctggtg tgtctcctac atgcaatttc cacggaccca   2820

gctctgtgga gggcatgact gctggccaga agctagtggt cctggggccc tatggttcga   2880

ctgagtccac actcccctgg agcctggctg gcctctgcaa acaaacataa ttttggggac   2940

cttccttcct gtttcttccc accctgtctt ctcccctagg tggttcctga gcccccaccc   3000

ccaatcccag tgctacacct gaggttctgg agctcagaat ctgacagcct ctcccccatt   3060

ctgtgtgtgt cggggggaca gagggaacca tttaagaaaa gataccaaag tagaagtcaa   3120

aagaaagaca tgttggctat aggcgtggtg gctcatgcct ataatcccag cactttggga   3180

agccggggta ggaggatcac cagaggccag caggtccaca ccagcctggg caacacagca   3240

agacaccgca tctacagaaa aattttaaaa ttagctgggc gtggtggtgt gtacctgtag   3300

gcctagctgc tcaggaggct gaagcaggag gatcacttga gcctgagttc aacactgcag   3360

tgagctatgg tggcaccact gcactccagc ctgggtgaca gagcaagacc ctgtctctaa   3420

aataaatttt aaaaagacat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                             3516


<210>  28
<211>  787
<212>  PRT
<213>  Homosapiens

<400>  28

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Asn Ser Asn 
625                 630                 635                 640 


His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys 
                645                 650                 655     


Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn 
            660                 665                 670         


His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu 
        675                 680                 685             


Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala 
    690                 695                 700                 


His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser 
705                 710                 715                 720 


Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu Gly Gly Val His 
                725                 730                 735     


Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp 
            740                 745                 750         


Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro 
        755                 760                 765             


Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln Met Pro Arg Ser 
    770                 775                 780                 


Cys Leu Trp 
785         


<210>  29
<211>  3594
<212>  DNA
<213>  Homosapiens

<400>  29
gctgcaccgg gcacgggtcg gccgcaatcc agcctgggcg gagccggagt tgcgagccgc     60

tgcctagagg ccgaggagct cacagctatg ggctggaggc cccggagagc tcgggggacc    120

ccgttgctgc tgctgctact actgctgctg ctctggccag tgccaggcgc cggggtgctt    180

caaggacata tccctgggca gccagtcacc ccgcactggg tcctggatgg acaaccctgg    240

cgcaccgtca gcctggagga gccggtctcg aagccagaca tggggctggt ggccctggag    300

gctgaaggcc aggagctcct gcttgagctg gagaagaacc acaggctgct ggccccagga    360

tacatagaaa cccactacgg cccagatggg cagccagtgg tgctggcccc caaccacacg    420

gatcattgcc actaccaagg gcgagtaagg ggcttccccg actcctgggt agtcctctgc    480

acctgctctg ggatgagtgg cctgatcacc ctcagcagga atgccagcta ttatctgcgt    540

ccctggccac cccggggctc caaggacttc tcaacccacg agatctttcg gatggagcag    600

ctgctcacct ggaaaggaac ctgtggccac agggatcctg ggaacaaagc gggcatgacc    660

agccttcctg gtggtcccca gagcaggggc aggcgagaag cgcgcaggac ccggaagtac    720

ctggaactgt acattgtggc agaccacacc ctgttcttga ctcggcaccg aaacttgaac    780

cacaccaaac agcgtctcct ggaagtcgcc aactacgtgg accagcttct caggactctg    840

gacattcagg tggcgctgac cggcctggag gtgtggaccg agcgggaccg cagccgcgtc    900

acgcaggacg ccaacgccac gctctgggcc ttcctgcagt ggcgccgggg gctgtgggcg    960

cagcggcccc acgactccgc gcagctgctc acgggccgcg ccttccaggg cgccacagtg   1020

ggcctggcgc ccgtcgaggg catgtgccgc gccgagagct cgggaggcgt gagcacggac   1080

cactcggagc tccccatcgg cgccgcagcc accatggccc atgagatcgg ccacagcctc   1140

ggcctcagcc acgaccccga cggctgctgc gtggaggctg cggccgagtc cggaggctgc   1200

gtcatggctg cggccaccgg gcacccgttt ccgcgcgtgt tcagcgcctg cagccgccgc   1260

cagctgcgcg ccttcttccg caaggggggc ggcgcttgcc tctccaatgc cccggacccc   1320

ggactcccgg tgccgccggc gctctgcggg aacggcttcg tggaagcggg cgaggagtgt   1380

gactgcggcc ctggccagga gtgccgcgac ctctgctgct ttgctcacaa ctgctcgctg   1440

cgcccggggg cccagtgcgc ccacggggac tgctgcgtgc gctgcctgct gaagccggct   1500

ggagcgctgt gccgccaggc catgggtgac tgtgacctcc ctgagttttg cacgggcacc   1560

tcctcccact gtcccccaga cgtttaccta ctggacggct caccctgtgc caggggcagt   1620

ggctactgct gggatggcgc atgtcccacg ctggagcagc agtgccagca gctctggggg   1680

cctggctccc acccagctcc cgaggcctgt ttccaggtgg tgaactctgc gggagatgct   1740

catggaaact gcggccagga cagcgagggc cacttcctgc cctgtgcagg gagggatgcc   1800

ctgtgtggga agctgcagtg ccagggtgga aagcccagcc tgctcgcacc gcacatggtg   1860

ccagtggact ctaccgttca cctagatggc caggaagtga cttgtcgggg agccttggca   1920

ctccccagtg cccagctgga cctgcttggc ctgggcctgg tagagccagg cacccagtgt   1980

ggacctagaa tggtgtgcca gagcaggcgc tgcaggaaga atgccttcca ggagcttcag   2040

cgctgcctga ctgcctgcca cagccacggg gtttgcaata gcaaccataa ctgccactgt   2100

gctccaggct gggctccacc cttctgtgac aagccaggct ttggtggcag catggacagt   2160

ggccctgtgc aggctgaaaa ccatgacacc ttcctgctgg ccatgctcct cagcgtcctg   2220

ctgcctctgc tcccaggggc cggcctggcc tggtgttgct accgactccc aggagcccat   2280

ctgcagcgat gcagctgggg ctgcagaagg gaccctgcgt gcagtggccc caaagatggc   2340

ccacacaggg accaccccct gggcggcgtt caccccatgg agttgggccc cacagccact   2400

ggacagccct ggcccctgga ccctgagaac tctcatgagc ccagcagcca ccctgagaag   2460

cctctgccag cagtctcgcc tgacccccaa gcagatcaag tccagatgcc aagatcctgc   2520

ctctggtgag aggtagctcc taaaatgaac agatttaaag acaggtggcc actgacagcc   2580

actccaggaa cttgaactgc aggggcagag ccagtgaatc accggacctc cagcacctgc   2640

aggcagcttg gaagtttctt ccccgagtgg agcttcgacc cacccactcc aggaacccag   2700

agccacatta gaagttcctg agggctggag aacactgctg ggcacactct ccagctcaat   2760

aaaccatcag tcccagaagc aaaggtcaca cagcccctga cctccctcac cagtggaggc   2820

tgggtagtgc tggccatccc aaaagggctc tgtcctggga gtctggtgtg tctcctacat   2880

gcaatttcca cggacccagc tctgtggagg gcatgactgc tggccagaag ctagtggtcc   2940

tggggcccta tggttcgact gagtccacac tcccctggag cctggctggc ctctgcaaac   3000

aaacataatt ttggggacct tccttcctgt ttcttcccac cctgtcttct cccctaggtg   3060

gttcctgagc ccccaccccc aatcccagtg ctacacctga ggttctggag ctcagaatct   3120

gacagcctct cccccattct gtgtgtgtcg gggggacaga gggaaccatt taagaaaaga   3180

taccaaagta gaagtcaaaa gaaagacatg ttggctatag gcgtggtggc tcatgcctat   3240

aatcccagca ctttgggaag ccggggtagg aggatcacca gaggccagca ggtccacacc   3300

agcctgggca acacagcaag acaccgcatc tacagaaaaa ttttaaaatt agctgggcgt   3360

ggtggtgtgt acctgtaggc ctagctgctc aggaggctga agcaggagga tcacttgagc   3420

ctgagttcaa cactgcagtg agctatggtg gcaccactgc actccagcct gggtgacaga   3480

gcaagaccct gtctctaaaa taaattttaa aaagacataa aaaaaaaaaa aaaaaaaaaa   3540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         3594


<210>  30
<211>  813
<212>  PRT
<213>  Homosapiens

<400>  30

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810             


<210>  31
<211>  329
<212>  DNA
<213>  Homosapiens

<400>  31
gttaaaaaga agaatgaaaa cccctcaagc cagattttat gactttttat atcacactga     60

aaagtccaat gaactacaga tttcaaccat ggagatttgt gccctactat gaaacggtga    120

ctgtaacaca gattgatgaa agattctgca ggacgacaaa ggttaaagat gtagacccgg    180

agctagaagc cagcactgac actgatggag tggactgcga tgagaatgcc cacattattg    240

tcctatcctc tgataaccaa tgtaatatga aaaccgacta cagaagaaag gaacaaatta    300

aatccattaa tcaagcatat ctctgctaa                                      329


<210>  32
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  32

Met Thr Phe Tyr Ile Thr Leu Lys Ser Pro Met Asn Tyr Arg Phe Gln 
1               5                   10                  15      


Pro Trp Arg Phe Val Pro Tyr Tyr Glu Thr Val Thr Val Thr Gln Ile 
            20                  25                  30          


Asp Glu Arg Phe Cys Arg Thr Thr Lys Val Lys Asp Val Asp Pro Glu 
        35                  40                  45              


Leu Glu Ala Ser Thr Asp Thr Asp Gly Val Asp Cys Asp Glu Asn Ala 
    50                  55                  60                  


His Ile Ile Val Leu Ser Ser Asp Asn Gln Cys Asn Met Lys Thr Asp 
65                  70                  75                  80  


Tyr Arg Arg Lys Glu Gln Ile Lys Ser Ile Asn Gln Ala Tyr Leu Cys 
                85                  90                  95      


<210>  33
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  33
cgggcctggg ctgtggctgt gactggcgct gccgtgggcg ccgcagccct cgcgggagcc     60

ggacgcggta atgccccagc ggcgcagcgg gcggctgcgt ccctgagccg ctatataagc    120

gcggcaggga acatccggag gggctgaaga tgaaggtgcc cgcgcatggg cccccgctga    180

ttgccagtcc ctcccgaccc cgcgccccgc gcggagcccg aggccgccga ggacccgcct    240

tcgccgcagt agcagctgga gcagcgacag aggcggcagc tgcggcggcg gcggcgcccg    300

cgcccctcgc gccagcgcgt agagcggcgg cggcagctcg ggggccgcca ctgccccggc    360

tgccatgagt tgtgcggagg tgatgtatca cccccagcct tatggagcgt cccagtatct    420

gcccaacccc atggcagcga caacctgccc cacagcctac tatcagccgg cgccccaacc    480

tggccagcag aagaagttag cggtattcag caagatgcag gactctctgg aagtcaccct    540

tcccagcaaa caagaggagg aggatgagga ggaggaggag gaggagaaag accagcctgc    600

cgagatggag taccttaact ctcgctgtgt ccttttcact tatttccagg gagacattgg    660

gtcagtagtg gatgaacact tctcaagagc tttgggccaa gccatcaccc tccatccaga    720

atctgccatt tcaaaaagca agatggggct aaccccccta tggcgagaca gctcagctct    780

ctcaagccag cggaatagtt tcccaacttc cttttggacc agctcttacc agcccccacc    840

tgcaccttgt ttggggggag ttcatcctga cttccaggtc actggacccc ctggcacctt    900

ttctgcagct gatcccagtc cttggccggg acacaacctg catcagactg gcccagcccc    960

tccccctgct gtgtctgagt cctggcctta tcctttgaca tctcaggtga gcccatccta   1020

cagccatatg catgacgtgt acatgcggca ccaccaccct catgcccaca tgcaccaccg   1080

ccaccgccac catcatcacc atcaccaccc tcctgctggc tctgccctgg atccatccta   1140

tgggcctctg ctgatgcctt cagtgcatgc ggccaggatt cctgctcccc agtgtgacat   1200

cacaaagaca gaaccaacta cagtcacctc tgctacctca gcatgggctg gagcctttca   1260

tggaacagta gacatagtgc ccagcgtggg attcgataca ggtctacagc atcaagacaa   1320

gagtaaggaa tcaccgtggt actgaaacac acaatcttag tgagttaagt tgcagcataa   1380

atccaagggc ccactgggaa aagatactgt cgggtttttc cattcagcaa taggacacga   1440

aaggcataga aggagaagac aaagtgtcac gcagttgact ggttttcggc ctttcttgag   1500

aaagcaaagt gggtcccaga cattgaagaa aagcattttt atttgtttat ttcctcatct   1560

gagcctttgc caactgtgca actctctcct tttgttatct tgcttttatc aatatatagc   1620

taagtttttg tttcattttg attttttttt ttagccaacc accttgtcag gaaaggatga   1680

accacacatt aaaatgttca ttctttcagg aatacaagtt tgtagctcta tgtgcatcta   1740

tttttgtaga aatacaaaaa gtttggttta gcattgatgg gctatttttg agggatgtat   1800

tttttttaaa attgtaaaaa ttgttgagtt ctgtttaaag aacttgctct cagagaagca   1860

ctggcaaaaa tgtttaaaat gcttatctct aagatgtcta ttatatgctc tgtctgtgct   1920

ttctaggtta cctcaaatgt tttgtttttt tccttcttac aaaagtagct ataccgtagt   1980

caaaccaatg cagtattgtt tttacattga atctcagtaa agatttaatt ccatgctagc   2040

tcaattagtt ttgaattata tgtatagctt gaaaagtttt tttttaatga ctgtgctaaa   2100

gaaatgatat tttattgctt tgatttctcc caaagaataa cttggaggtt gactaataag   2160

aaagttggca taaactttca atcaaatgaa gagtttgcct agaggagact aattctcttt   2220

ctagcccatc caaatttgat aaatggaacc agaggttata tacaactaca aggaaaaaaa   2280

tgcatttaac catgccacct atgagtgcca gtgacttatt ttacttgttt ttaattattc   2340

attcatggca atttaaaaag tcatatttta agtgggattt gtttttcctg aagggcattt   2400

gaaggaacaa tatctgggaa ggtactagag aaattacaaa gcccgagctc tttcttataa   2460

tgccacctat ccctgtaagc taaacaaaca aacaaacaaa caaacaaaca gttctatata   2520

taatagtttc aacacagaac ttaacaagtc tctttttttg tttgtttaaa tctggcttta   2580

cttgatttaa ttccttttta gaaagaaatt tagggcaaaa taaagtgtat attaggattt   2640

aaatttatgc cacaatttaa aaataaaacc agaggttata tacaatttaa attgggctaa   2700

aaattaaaaa tttgaggatt taacttgata tagctctcag gatctaaata aagtttaaat   2760

tatcattaag acactgctag gagaagatta agattatgaa agtaacagtt attgatactg   2820

ctggacttca aaggcaaagt tcatttcttc cattaactgc ttccagagat gtcatgtaaa   2880

aaagttagtg tattagagaa gttttttagc tttataaaga ggttttttca aatttctccc   2940

atttttctct ccacccacat aaaatagtat gttcagtgaa atgccacttt ctatctttaa   3000

ttgttcgtat catatatgcg aactttttag acatgaacat gacatgttca gctaggcaga   3060

gttctcatag ataattttca aatattttcc ttggctgtaa tttatgtatt catttatatc   3120

ctatccgtct tttgagcttc agatctatat actcttttgt actctcatca ctccgcactt   3180

tgctgtttct tacctagact ctcttttaca caatatgcac atttttacca ttgtggggtc   3240

caaatttaag ataccttcca ctcactaata atatgaactt atatttcctg ggagtagcca   3300

ggttaaattt tctatacttt ggtccataat ttgatttgat atgattgttt catttataat   3360

ttgcccaaat acatggagca caaaatttag tgaatttata aatctggatt tgccttgtgt   3420

ccttctgagt tttcaaaggc aagtattcaa cagtccctgt gtgatgactg acagggttat   3480

ttgcctcatc cacatccacc ttcggaatac attaacttcc tttgtaattt atttgaaagt   3540

agtgttaaac tcattcagat cattcagttg gattttccca atgaagagga aaaggaaagt   3600

agttattcct agctccattt cttattttcc accaaattta attgaagggc attaattaga   3660

tgtcttcacc ctgaatttag actttgctct gtgttctccc ggtaactgtc agacaaaaag   3720

tttattggct ctgaggaact gagaaatgtt gggaacctgg tttctgctgt acacaggaaa   3780

gatttgtaag tgagctctct ctttgaaaac aggacccagg ctgggcacag cagctcatgc   3840

ctgtaatcct agtattatag gaggcagagg ctcgggagga ttgcttgagc ccaggagttc   3900

aagatcagcc taggcaacat agggagaccc tatccctaca aaaaatttct gaaaaattac   3960

ctgggcattg tggggcacac ctgttgtccc agctactctg gaggctgagt ccggaggaac   4020

gtttgagcct gggagtttga gtttgcagct tgcagtgagc tgtgattgca ccactgtact   4080

ccagcttggg caacagagca agatcctgtc tcaaaaggaa aaagaaaaca ggacctaggt   4140

gtttggggta cactgccacc cagggagtgg atcaaaaata tacatagaaa gagaatgagc   4200

atgtctctat aattgtcttc taggaccata ttgctgttag aagtcctaaa agaggatggg   4260

ttgtaattta gcataatatt ctgaattcat tccaagttta aaatcctgtc attctctggc   4320

tcttcttttt tcacatcaaa atgatgctgt tggacttaga ggcttccgaa ctgttttatt   4380

gagggctact atctgcctcc acaattttat taaaaccact ccacctttag acaaaggtga   4440

cttttgtctg attttacaaa tcagatttta ttcaagcttt ctaaatatct gtgaagtaga   4500

ccctagaaaa ttgtctcgtt tattttaaat agaatctatg cttccaccaa taaaccatcg   4560

ggagctaaga aacaacataa tgttgacaaa tcaggaacct aacagattat tttgtctctc   4620

attattaatt tgaaagagcc tctaaacttt tgagaaatca atgtgtcttc ttaagaaagt   4680

taagcaccct ctcttaactt tcccctctat ttgctctcct ttttctttct tcttaagagt   4740

atttatatta ttttgttaag caaaaatggc taagattgct ctaaaatttg caaaatgagg   4800

agtggattgc aaataattga gggatttatt tctttaactt tataagactt taaaaaaaaa   4860

acccaaattc taagcactga catgaaagtt gcctttgaga agcttgttat tcattataca   4920

aaaagtattt gcccattcct attctaagat ttgcagaata tgtcacccta tctagctttt   4980

gagtttgcta tctggtttaa tgttgtattt ataatttaaa gtggaaatca gaaactgttt   5040

caagaacctg tattctattc cttactgagt gtcccttctt taaatagtgt ttgctgaatt   5100

aagccgatgg gggcagtggc gttaagtggt ggaaaaagga aagtatatat gttagagttt   5160

tgaatgaggg ataaatagaa agcagaatga attaatggaa aagaactcgg ctgttaggcc   5220

attctctaaa ttctagttta gccaaaagtt tatgtgtggt ttggggcttc atttatttat   5280

ctcatgagta aaatggaata atacctaaca ggcaggctct ggaagttgga aatcacatac   5340

acacacacac acacacagac acacacacac acgatcaatc atgtagctca tattagatgt   5400

tcaataaata acagctacta cagatgccta tcagttgagt aagtagttca ttaaattgag   5460

ctcccaaagg tctcttctct tcacatccat atccgtttct gcagcaatca aatagataca   5520

tgattgtttt tctgtaagaa attactgcaa agagaatctt tttctcctac taactgttcc   5580

ttctacctgg tataggagat aaatgtacgt ttcttaatta gctgactttt tagtatgtca   5640

tttctgaagg aaaaataaat taaccttaaa gtggcatgta ggtccaattc agttttccta   5700

catgttccaa aattttattt aaattactgt gtccaaaatt atgaggacag tgtcattcat   5760

tcaccatagt ttatattttt agttatatat caaacttcct tggcacctag gataagaaca   5820

tttcttttga agttatccaa ttttttttta tttttacttg acttgaagga aagttggaaa   5880

atatggtgga aaaaatcttc cgcattaaaa gggggaaaaa cacaaccatt tacgatctca   5940

gtcagcagat ttactctact caaggaaaaa aagaaacaat cttattggaa gcagatgttg   6000

acactgtgtc agttattgaa gacggaagga gttcacttga gccattgcag ttacaaaggg   6060

gtattgatgg cagtttggat tcctgattga tcacctttgc agccaaggga aagacagcag   6120

aaactgtatg ggatcagaaa tgaaatcagc ctgccagttt aatggagagg ctcctagaaa   6180

ctcatttttt ttctttcctg taagataaaa gacatctttc agaataagaa aggcttgttt   6240

gagagagaaa ttacagttta ttctctgaaa atatttaaag gccaaagtgc cctttaaatc   6300

tattattaaa gcattgaaac tgttattaaa atcattatag aaaaattagg taaaaatttt   6360

agcctaactt tcaacatcca ttcaaaaacg aatgttgaaa acaaacatat aacctataaa   6420

aaagtgaatg gctctggcaa gtgggggcat gggtggagtc cataaggaaa cctcagtctc   6480

aataacttca aaatgttact tttcatggta acttggtcat ggagattggt cacagcacag   6540

acatttagaa ttttttagca ggtttttttt ttcttttgaa tcttgtagtg ctctctggga   6600

attgcaccat gtacactttt acaacctaca gaaatcgtca ttattgttaa agtatctcaa   6660

cttttctatt tcttttattg tctattgtgc ttttttgttt aaaaatactt ttatagtttt   6720

aaagtattgg tcaaagtagt attctcttga agttctagtc aatttaattt gatccaataa   6780

gtttttctga atctcctttt taagttccaa gaaattctat tataaataag tgtactttta   6840

ccaattccat tgtataagca aacagacacc ttttagaaaa ggataagtaa tcatcaattt   6900

gtttttttaa aaaaaaaaac aatttctaga ctactaaatt tggcataaga ataattcttt   6960

taaaatgcaa catactttaa ttagtttttt tggtatatgc ataagatgtg aactttccta   7020

ttgatatcac tttatattaa tagagatgta catttctttc tatgccgtgg ctagagcaaa   7080

agttaataat gattatttac acaattgatt taatttctta ggatatgtat aatattggat   7140

attatatctg atttaaaaat actattccat acattttttt tttcaggaga taaaacatag   7200

ggaaaggttt tcatgtgaat tctttgtatc actttgaagt acatatattt aaagggaaga   7260

tggatacaat ttgtttttat tatataaatc taggtaaggt gaaatgcttt tgtcaacaaa   7320

aatacagtgt agtgaatttt atatttgtca cttgattagg taaactgaaa actaacaata   7380

gaaatattat tttactgcat tgaaatacca tgaactttca gacttgttag ttctacaaga   7440

agttgtgcta ccttaatttt gtgtttccag aaataaaaat taaccttagt tatgctgtca   7500

tttttaacta ataaaaaaag tataattcat aaaacttttg gctttataag ataattataa   7560

aattatatat ttttttctgt ttttgtgggg ttgggaaaac attttcttat ttctattcac   7620

tcttcaaatg caggtctcat aatatgtgtc aatgatataa gatgatggaa gactttgtaa   7680

taaaaacata tgtcattatc ttcaatttgt tcaataaata atttaatgtg aattgaatgt   7740

ttgtatttta acatagcatt tggatttggt ctgcatttct tgagaattta aagctctttt   7800

tgtttcctcc ttattcaatt aagcatctta taaatatttt ggaaattaca acatcttagg   7860

tgttattaat taagaagtta atttctaggg ccaagaagtc tatatgttac agcaaggaat   7920

agattataaa atacatgttt ataatggaaa agaaaatgaa atggggtata ttaattacat   7980

aacagcaaga gtcttgagaa ttttataata caatgcttct aaggatattg gttgaccaag   8040

gtgtatttta ttgtttttac atttgttgac agggactctg ccataagtag tatgaaaaaa   8100

caaacaaaaa cttttctacg attcattaac attgaaaaga gaattccaag accttgtatt   8160

ctgaagaaag ctagagtttc tctaagtggg cc                                 8192


<210>  34
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  34

Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala Ser 
1               5                   10                  15      


Gln Tyr Leu Pro Asn Pro Met Ala Ala Thr Thr Cys Pro Thr Ala Tyr 
            20                  25                  30          


Tyr Gln Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val Phe 
        35                  40                  45              


Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln Glu 
    50                  55                  60                  


Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Gln Pro Ala Glu 
65                  70                  75                  80  


Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr Phe Gln Gly 
                85                  90                  95      


Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala Leu Gly Gln 
            100                 105                 110         


Ala Ile Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser Lys Met Gly 
        115                 120                 125             


Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser Gln Arg Asn 
    130                 135                 140                 


Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro Pro Pro Ala 
145                 150                 155                 160 


Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr Gly Pro Pro 
                165                 170                 175     


Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro Gly His Asn Leu 
            180                 185                 190         


His Gln Thr Gly Pro Ala Pro Pro Pro Ala Val Ser Glu Ser Trp Pro 
        195                 200                 205             


Tyr Pro Leu Thr Ser Gln Val Ser Pro Ser Tyr Ser His Met His Asp 
    210                 215                 220                 


Val Tyr Met Arg His His His Pro His Ala His Met His His Arg His 
225                 230                 235                 240 


Arg His His His His His His His Pro Pro Ala Gly Ser Ala Leu Asp 
                245                 250                 255     


Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His Ala Ala Arg Ile 
            260                 265                 270         


Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Glu Pro Thr Thr Val Thr 
        275                 280                 285             


Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp Ile 
    290                 295                 300                 


Val Pro Ser Val Gly Phe Asp Thr Gly Leu Gln His Gln Asp Lys Ser 
305                 310                 315                 320 


Lys Glu Ser Pro Trp Tyr 
                325     


<210>  35
<211>  2410
<212>  DNA
<213>  Homosapiens

<400>  35
gtccttttcc tcctgtcctt tgccagcgtt gggccggacc gggccgagcc gggccgcccg     60

ggcgcagtct ttaaccatgg cgtccctctt caagaagaaa accgtggatg atgtaataaa    120

ggaacagaat cgagagttac gaggtacaca gagggctata atcagagatc gagcagcttt    180

agagaaacaa gaaaaacagc tggaattaga aattaagaaa atggccaaga ttggtaataa    240

ggaagcttgc aaagttttag ccaaacaact tgtgcatcta cggaaacaga agacgagaac    300

ttttgctgta agttcaaaag ttacttctat gtctacacaa acaaaagtga tgaattccca    360

aatgaagatg gctggagcaa tgtctaccac agcaaaaaca atgcaggcag ttaacaagaa    420

gatggatcca caaaagacat tacaaacaat gcagaatttc cagaaggaaa acatgaaaat    480

ggaaatgact gaagaaatga tcaatgatac acttgatgac atctttgacg gttctgatga    540

cgaagaagaa agccaggata ttgtgaatca agttcttgat gaaattggaa ttgaaatttc    600

tggaaagatg gccaaagctc catcagctgc tcgaagctta ccatctgcct ctacttcaaa    660

ggctacaatc tcagatgaag agattgaacg gcaactcaag gctttaggag tagattagtc    720

aaaagaagtc atactatttt gcttacttat aattatgtag tataaaccaa gcacagtgca    780

gatttctttt acaaaacaca tgtattttgc aaaaaaaaaa aaaatgaaga ccatgagtga    840

acagttgttt cctaacccat ggctatttag aatcttttgc caaagaatga caatgatgca    900

aaaatgggaa cagtttggat tttaattaga actgtttagg agtgatgatg tgtaaaaagt    960

tgacttctct tttgcatggc acagagaaat tatattcctt acttcatgtc agtttatgtt   1020

ctaaatcttt ttcactgaat ataaaaatct tgttaaatgc cattaggcac caacttaaag   1080

agggttgtaa aaatattaaa agtatatcgt taattctgta tctgttgctt gtcttttgta   1140

agtgattatg tgttatgacc ataggtggtt acagctgcca aattattttt aaatggtcaa   1200

aaagaagagt gctatttaaa catctgtctt aaacaaaaac tgtcataact tttctttttt   1260

ctttttccat taggagaaca ttctagttgg taaatttcaa aatgtgcttg acacctgcct   1320

taaatagcac agacctattg tgcacatctt taaattattt cagctggcag aaaagaatta   1380

catttaaaac tgaaatcaag gcctcaatac aaagattatc ctggctcttt tctatctctg   1440

tgggcctaat tgaaatatgt actcttattt tagacacgcc tctgttaaaa cagaccaggt   1500

tttcctggtc tcagacctat gatgacttgt ccctttgatg tcactactgt gaattgaata   1560

taattagtaa aaatagacga tgaataaata acactttata gtaagaaaac aatatatttt   1620

ggccatctaa aaatgagaat tataattata tgaattataa tttaaactgt ttaattttgt   1680

ttaatgtgta tattgaatct tccaaattga agccattatt ctcaattaag tactacaact   1740

atgacaatgc ttgacctaca tttctaaaat aaaaattcac attttttgat aaataaacta   1800

cagttttacc agaaattact atctaaatgt gtattagcag tattttttaa ggtgaaattg   1860

ccttggtatc taatgaatgt gtagacaggg agataaaatg aaggattgcc agactagtta   1920

gaatagaatt taggattagg ttagttttga aaaatgatgt tgtaatatat gggttctaac   1980

acatcctacc ataaaaactg gaggagatat gtgtaacctg gttaatttgg gatggtggac   2040

attttgggct aatactgaca aaatacatct taggactagt atacatgtga cacggattgc   2100

taggaggaat gaaaaactaa actgtatagt ttatattccg taaaccattt tataatgttc   2160

aaagattagg ttttgttatt gatagtatta aatacacagt ttctcttaac agtgatgggt   2220

gaaaacattt taccggatta tggaatgttt accagaacat gttttgattc ttgaatgtac   2280

ataataatgc catctaactt atttacattc ttgtttacat gtgggagctt ttgttttcaa   2340

aaattatttt gttaaaaaat ctcaataaag atttattatt gttgttcttt tcttaaaaaa   2400

aaaaaaaaaa                                                          2410


<210>  36
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  36

Met Ala Ser Leu Phe Lys Lys Lys Thr Val Asp Asp Val Ile Lys Glu 
1               5                   10                  15      


Gln Asn Arg Glu Leu Arg Gly Thr Gln Arg Ala Ile Ile Arg Asp Arg 
            20                  25                  30          


Ala Ala Leu Glu Lys Gln Glu Lys Gln Leu Glu Leu Glu Ile Lys Lys 
        35                  40                  45              


Met Ala Lys Ile Gly Asn Lys Glu Ala Cys Lys Val Leu Ala Lys Gln 
    50                  55                  60                  


Leu Val His Leu Arg Lys Gln Lys Thr Arg Thr Phe Ala Val Ser Ser 
65                  70                  75                  80  


Lys Val Thr Ser Met Ser Thr Gln Thr Lys Val Met Asn Ser Gln Met 
                85                  90                  95      


Lys Met Ala Gly Ala Met Ser Thr Thr Ala Lys Thr Met Gln Ala Val 
            100                 105                 110         


Asn Lys Lys Met Asp Pro Gln Lys Thr Leu Gln Thr Met Gln Asn Phe 
        115                 120                 125             


Gln Lys Glu Asn Met Lys Met Glu Met Thr Glu Glu Met Ile Asn Asp 
    130                 135                 140                 


Thr Leu Asp Asp Ile Phe Asp Gly Ser Asp Asp Glu Glu Glu Ser Gln 
145                 150                 155                 160 


Asp Ile Val Asn Gln Val Leu Asp Glu Ile Gly Ile Glu Ile Ser Gly 
                165                 170                 175     


Lys Met Ala Lys Ala Pro Ser Ala Ala Arg Ser Leu Pro Ser Ala Ser 
            180                 185                 190         


Thr Ser Lys Ala Thr Ile Ser Asp Glu Glu Ile Glu Arg Gln Leu Lys 
        195                 200                 205             


Ala Leu Gly Val Asp 
    210             


<210>  37
<211>  1262
<212>  DNA
<213>  Homosapiens

<400>  37
ctcagagcct tcctgatgta tatatgcagg tagtgagaat tgaatcggcc ctttgagaca     60

gtaatataat aaaactctga tttggggagc agcggttctc cttatttttc tactctcttg    120

tgggaatgag ttgccaagct tttacttcgg ctgatacctt tatacctctg aattctgacg    180

cctctgcaac tctgcctctg ataatgcatc acagtgctgc cgagtgtcta ccagtctcca    240

accatgccac caatgtgatg tctacagcaa caggacttca ttattctgtt ccttcctgtc    300

attatggaaa ccagccatca acctatggag tgatggcagg tagtttaacc ccttgtcttt    360

ataaatttcc tgaccacacc ttgagtcatg gatttcctcc tatacaccag cctcttctgg    420

cagaggaccc cacagctgct gatttcaagc aggaactcag gcggaaaagt aaattggtgg    480

aagagccaat agacatggat tctccagaaa tcagagaact tgaaaagttt gccaatgaat    540

ttaaagtgag acgaattaaa ttaggataca cccagacaaa tgttggggag gccctggcag    600

ctgtgcatgg ctctgaattc agtcaaacaa caatctgccg atttgaaaat ctgcagctca    660

gctttaaaaa tgcatgcaaa ctgaaagcaa tattatccaa atggctggag gaagctgagc    720

aagtaggagc tttgtacaat gaaaaagtgg gagcaaatga aaggaaaaga aaacgaagaa    780

caactataag cattgctgct aaagatgctc tggagagaca ctttggagaa cagaataaac    840

cttcttctca agagatcatg aggatggctg aagaactgaa tctggagaaa gaagtagtaa    900

gagtttggtt ttgcaaccgg aggcagagag aaaaacgggt gaaaacaagt ctgaatcaga    960

gtttattttc tatttctaag gaacatcttg agtgcagata agatttttct attgtataat   1020

agcctttttc tcccgtttca ttcctttctc ttcctcaaca aaaacagaaa ttacttggtt   1080

gacttaaaat cattttatat caatagcttt tacagaagct ttacttttcc actttttttt   1140

aaaaaaaaga aaccaacaat ttaaattata ttgatgttat ttacttaaaa taattattct   1200

cagaagccac attatctatt ttaagccaaa tatattaaca gtaataaaat gatctctctg   1260

tc                                                                  1262


<210>  38
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  38

Met Ser Cys Gln Ala Phe Thr Ser Ala Asp Thr Phe Ile Pro Leu Asn 
1               5                   10                  15      


Ser Asp Ala Ser Ala Thr Leu Pro Leu Ile Met His His Ser Ala Ala 
            20                  25                  30          


Glu Cys Leu Pro Val Ser Asn His Ala Thr Asn Val Met Ser Thr Ala 
        35                  40                  45              


Thr Gly Leu His Tyr Ser Val Pro Ser Cys His Tyr Gly Asn Gln Pro 
    50                  55                  60                  


Ser Thr Tyr Gly Val Met Ala Gly Ser Leu Thr Pro Cys Leu Tyr Lys 
65                  70                  75                  80  


Phe Pro Asp His Thr Leu Ser His Gly Phe Pro Pro Ile His Gln Pro 
                85                  90                  95      


Leu Leu Ala Glu Asp Pro Thr Ala Ala Asp Phe Lys Gln Glu Leu Arg 
            100                 105                 110         


Arg Lys Ser Lys Leu Val Glu Glu Pro Ile Asp Met Asp Ser Pro Glu 
        115                 120                 125             


Ile Arg Glu Leu Glu Lys Phe Ala Asn Glu Phe Lys Val Arg Arg Ile 
    130                 135                 140                 


Lys Leu Gly Tyr Thr Gln Thr Asn Val Gly Glu Ala Leu Ala Ala Val 
145                 150                 155                 160 


His Gly Ser Glu Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Asn Leu 
                165                 170                 175     


Gln Leu Ser Phe Lys Asn Ala Cys Lys Leu Lys Ala Ile Leu Ser Lys 
            180                 185                 190         


Trp Leu Glu Glu Ala Glu Gln Val Gly Ala Leu Tyr Asn Glu Lys Val 
        195                 200                 205             


Gly Ala Asn Glu Arg Lys Arg Lys Arg Arg Thr Thr Ile Ser Ile Ala 
    210                 215                 220                 


Ala Lys Asp Ala Leu Glu Arg His Phe Gly Glu Gln Asn Lys Pro Ser 
225                 230                 235                 240 


Ser Gln Glu Ile Met Arg Met Ala Glu Glu Leu Asn Leu Glu Lys Glu 
                245                 250                 255     


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Arg Glu Lys Arg Val 
            260                 265                 270         


Lys Thr Ser Leu Asn Gln Ser Leu Phe Ser Ile Ser Lys Glu His Leu 
        275                 280                 285             


Glu Cys Arg 
    290     


<210>  39
<211>  2070
<212>  DNA
<213>  Homosapiens

<400>  39
gggggatcag gcctcgcagt gggacgttgg gaagccggtg ttggcagatg ctgtggctgg     60

gaggagtcca gacgttcgcc ctgtcccgcg gggctgagcc acaactgctt aggagttttg    120

ggcaggatcg atggatgcag gaagcagtag gagtttggag aatgcagtga ataggatcta    180

tcatgatcag cttgttccaa agataaacac aagcaagaaa atgtccacct tagcgcaccc    240

acctaacatc ctggaaatgt cacaagagat taagaaaaac tgtggaggta aacaggtaga    300

aatcacactt gaaagaacaa aaatgacaaa gggcatcaaa gaaaaacaaa gcaatgattt    360

agagaaagca gcctttaaac ggaaggcaga aggtgaagaa aagccaacta gaaagaaaca    420

ggcaaagata acagaacttg acaatcagtt aatcaccatg cctctgcctc acatcccctt    480

aaagaacata atggatgtgg aaatgaagtt ggtctacatt gatgaaatgg gtgttcgcta    540

tgagtttgta gagtccttca tgtctactgg gagtcagcca acatgccaag ctgctgaaat    600

agtagaccct ttgagtgtac ataatttcag ctttctgcct cagattgaca aatggcttca    660

ggtagcctta aaggatgcca gctcttgcta tagacaaaag aaatacgcct tggcagcagg    720

acagttcaga acagcacttg agctttgcag caaaggagca gttctgggag aaccatttga    780

tgcacctgct gaagatatag caagtgtggc aagtttcatt gagacaaagc ttgttacctg    840

ttatctacgg atgaggaaac cagatcttgc cctgaatcat gcacacagga gcattgtttt    900

aaacccagcc tatttccgga atcatcttcg tcaagcaaca gtgtttagat gtctggagag    960

gtattcagag gctgcccgga gtgccgtgat tgctgactac atgttctggc ttggtggagg   1020

aagggaagag agcataagca agctcatcaa actgtattgg caggccatga ttgaggaagc   1080

catcaccaga gctgaatctt tctcggttat gtacacacca tttgcgacaa aaataagagc   1140

tgataaaata gaaaaagtaa aagatgcttt cacaaaaact catcctgcat atgcagagta   1200

tatgtacaca gatcttcaag cactccacat gttgcctcag acagttgact ggtcatcttt   1260

tcctccccaa caatatctct tgactcttgg gttcaaaaac aaagatgatg gaaaattttt   1320

ggaaaaaata tcaagcagga agctgccgat attcacagag cataaaacac ctttcggtct   1380

gaccagagaa gatacagtga ggcaaatgga gacaatgggg aagcgaatct tgccaatatt   1440

ggattttatt agaagcaccc aattgaatgg gagttttcct gcatcctcag gtgtgatgga   1500

gaagttgcaa tatgccagcc tcctcagcca gctgcagaga gtaaaggagc agtcccaggt   1560

gattaatcaa gcaatggcag agctagcaac cattccctac ctacaggaca tcagtcaaca   1620

ggaggcagaa ttgctgcagt cactaatggc agatgctatg gacacccttg aaggaagaag   1680

aaacaataat gaacgtgtgt ggaatatgat ccaaaaggtt ggacaaattg aagattttct   1740

ataccaatta gaggacagtt tcttaaaaac taaaaaactg agaactgctc gaaggcaaaa   1800

aacaaaaatg aagcgacttc aaactgttca gcaaaggtag tcattaggga gcaggcacta   1860

ccactaagat atcccagaag aagaggcaag ggcatccact ccaatgccca cctagtactg   1920

tgaagctgga taacaaaagc ttgtcaccaa aagaaagagg tggtattccc ctcagttcat   1980

ctttaccaaa gacactctat gtttcattaa tctcaactgg cagcaataaa tattctcagc   2040

aagttggact cgaaaaaaaa aaaaaaaaaa                                    2070


<210>  40
<211>  569
<212>  PRT
<213>  Homosapiens

<400>  40

Met Asp Ala Gly Ser Ser Arg Ser Leu Glu Asn Ala Val Asn Arg Ile 
1               5                   10                  15      


Tyr His Asp Gln Leu Val Pro Lys Ile Asn Thr Ser Lys Lys Met Ser 
            20                  25                  30          


Thr Leu Ala His Pro Pro Asn Ile Leu Glu Met Ser Gln Glu Ile Lys 
        35                  40                  45              


Lys Asn Cys Gly Gly Lys Gln Val Glu Ile Thr Leu Glu Arg Thr Lys 
    50                  55                  60                  


Met Thr Lys Gly Ile Lys Glu Lys Gln Ser Asn Asp Leu Glu Lys Ala 
65                  70                  75                  80  


Ala Phe Lys Arg Lys Ala Glu Gly Glu Glu Lys Pro Thr Arg Lys Lys 
                85                  90                  95      


Gln Ala Lys Ile Thr Glu Leu Asp Asn Gln Leu Ile Thr Met Pro Leu 
            100                 105                 110         


Pro His Ile Pro Leu Lys Asn Ile Met Asp Val Glu Met Lys Leu Val 
        115                 120                 125             


Tyr Ile Asp Glu Met Gly Val Arg Tyr Glu Phe Val Glu Ser Phe Met 
    130                 135                 140                 


Ser Thr Gly Ser Gln Pro Thr Cys Gln Ala Ala Glu Ile Val Asp Pro 
145                 150                 155                 160 


Leu Ser Val His Asn Phe Ser Phe Leu Pro Gln Ile Asp Lys Trp Leu 
                165                 170                 175     


Gln Val Ala Leu Lys Asp Ala Ser Ser Cys Tyr Arg Gln Lys Lys Tyr 
            180                 185                 190         


Ala Leu Ala Ala Gly Gln Phe Arg Thr Ala Leu Glu Leu Cys Ser Lys 
        195                 200                 205             


Gly Ala Val Leu Gly Glu Pro Phe Asp Ala Pro Ala Glu Asp Ile Ala 
    210                 215                 220                 


Ser Val Ala Ser Phe Ile Glu Thr Lys Leu Val Thr Cys Tyr Leu Arg 
225                 230                 235                 240 


Met Arg Lys Pro Asp Leu Ala Leu Asn His Ala His Arg Ser Ile Val 
                245                 250                 255     


Leu Asn Pro Ala Tyr Phe Arg Asn His Leu Arg Gln Ala Thr Val Phe 
            260                 265                 270         


Arg Cys Leu Glu Arg Tyr Ser Glu Ala Ala Arg Ser Ala Val Ile Ala 
        275                 280                 285             


Asp Tyr Met Phe Trp Leu Gly Gly Gly Arg Glu Glu Ser Ile Ser Lys 
    290                 295                 300                 


Leu Ile Lys Leu Tyr Trp Gln Ala Met Ile Glu Glu Ala Ile Thr Arg 
305                 310                 315                 320 


Ala Glu Ser Phe Ser Val Met Tyr Thr Pro Phe Ala Thr Lys Ile Arg 
                325                 330                 335     


Ala Asp Lys Ile Glu Lys Val Lys Asp Ala Phe Thr Lys Thr His Pro 
            340                 345                 350         


Ala Tyr Ala Glu Tyr Met Tyr Thr Asp Leu Gln Ala Leu His Met Leu 
        355                 360                 365             


Pro Gln Thr Val Asp Trp Ser Ser Phe Pro Pro Gln Gln Tyr Leu Leu 
    370                 375                 380                 


Thr Leu Gly Phe Lys Asn Lys Asp Asp Gly Lys Phe Leu Glu Lys Ile 
385                 390                 395                 400 


Ser Ser Arg Lys Leu Pro Ile Phe Thr Glu His Lys Thr Pro Phe Gly 
                405                 410                 415     


Leu Thr Arg Glu Asp Thr Val Arg Gln Met Glu Thr Met Gly Lys Arg 
            420                 425                 430         


Ile Leu Pro Ile Leu Asp Phe Ile Arg Ser Thr Gln Leu Asn Gly Ser 
        435                 440                 445             


Phe Pro Ala Ser Ser Gly Val Met Glu Lys Leu Gln Tyr Ala Ser Leu 
    450                 455                 460                 


Leu Ser Gln Leu Gln Arg Val Lys Glu Gln Ser Gln Val Ile Asn Gln 
465                 470                 475                 480 


Ala Met Ala Glu Leu Ala Thr Ile Pro Tyr Leu Gln Asp Ile Ser Gln 
                485                 490                 495     


Gln Glu Ala Glu Leu Leu Gln Ser Leu Met Ala Asp Ala Met Asp Thr 
            500                 505                 510         


Leu Glu Gly Arg Arg Asn Asn Asn Glu Arg Val Trp Asn Met Ile Gln 
        515                 520                 525             


Lys Val Gly Gln Ile Glu Asp Phe Leu Tyr Gln Leu Glu Asp Ser Phe 
    530                 535                 540                 


Leu Lys Thr Lys Lys Leu Arg Thr Ala Arg Arg Gln Lys Thr Lys Met 
545                 550                 555                 560 


Lys Arg Leu Gln Thr Val Gln Gln Arg 
                565                 


<210>  41
<211>  3007
<212>  DNA
<213>  Homosapiens

<400>  41
gcccggagag ccgcatctat tggcagcttt gttattgatc agaaactgct cgccgccgac     60

ttggcttcca gtctggctgc gggcaaccct tgagttttcg cctctgtcct gtcccccgaa    120

ctgacaggtg ctcccagcaa cttgctgggg acttctcgcc gctcccccgc gtccccaccc    180

cctcattcct ccctcgcctt cacccccacc cccaccactt cgccacagct caggatttgt    240

ttaaaccttg ggaaactggt tcaggtccag gttttgcttt gatccttttc aaaaactgga    300

gacacagaag agggctctag gaaaaagttt tggatgggat tatgtggaaa ctaccctgcg    360

attctctgct gccagagcag gctcggcgct tccaccccag tgcagccttc ccctggcggt    420

ggtgaaagag actcgggagt cgctgcttcc aaagtgcccg ccgtgagtga gctctcaccc    480

cagtcagcca aatgagcctc ttcgggcttc tcctgctgac atctgccctg gccggccaga    540

gacaggggac tcaggcggaa tccaacctga gtagtaaatt ccagttttcc agcaacaagg    600

aacagaacgg agtacaagat cctcagcatg agagaattat tactgtgtct actaatggaa    660

gtattcacag cccaaggttt cctcatactt atccaagaaa tacggtcttg gtatggagat    720

tagtagcagt agaggaaaat gtatggatac aacttacgtt tgatgaaaga tttgggcttg    780

aagacccaga agatgacata tgcaagtatg attttgtaga agttgaggaa cccagtgatg    840

gaactatatt agggcgctgg tgtggttctg gtactgtacc aggaaaacag atttctaaag    900

gaaatcaaat taggataaga tttgtatctg atgaatattt tccttctgaa ccagggttct    960

gcatccacta caacattgtc atgccacaat tcacagaagc tgtgagtcct tcagtgctac   1020

ccccttcagc tttgccactg gacctgctta ataatgctat aactgccttt agtaccttgg   1080

aagaccttat tcgatatctt gaaccagaga gatggcagtt ggacttagaa gatctatata   1140

ggccaacttg gcaacttctt ggcaaggctt ttgtttttgg aagaaaatcc agagtggtgg   1200

atctgaacct tctaacagag gaggtaagat tatacagctg cacacctcgt aacttctcag   1260

tgtccataag ggaagaacta aagagaaccg ataccatttt ctggccaggt tgtctcctgg   1320

ttaaacgctg tggtgggaac tgtgcctgtt gtctccacaa ttgcaatgaa tgtcaatgtg   1380

tcccaagcaa agttactaaa aaataccacg aggtccttca gttgagacca aagaccggtg   1440

tcaggggatt gcacaaatca ctcaccgacg tggccctgga gcaccatgag gagtgtgact   1500

gtgtgtgcag agggagcaca ggaggatagc cgcatcacca ccagcagctc ttgcccagag   1560

ctgtgcagtg cagtggctga ttctattaga gaacgtatgc gttatctcca tccttaatct   1620

cagttgtttg cttcaaggac ctttcatctt caggatttac agtgcattct gaaagaggag   1680

acatcaaaca gaattaggag ttgtgcaaca gctcttttga gaggaggcct aaaggacagg   1740

agaaaaggtc ttcaatcgtg gaaagaaaat taaatgttgt attaaataga tcaccagcta   1800

gtttcagagt taccatgtac gtattccact agctgggttc tgtatttcag ttctttcgat   1860

acggcttagg gtaatgtcag tacaggaaaa aaactgtgca agtgagcacc tgattccgtt   1920

gccttgctta actctaaagc tccatgtcct gggcctaaaa tcgtataaaa tctggatttt   1980

tttttttttt tttgctcata ttcacatatg taaaccagaa cattctatgt actacaaacc   2040

tggtttttaa aaaggaacta tgttgctatg aattaaactt gtgtcgtgct gataggacag   2100

actggatttt tcatatttct tattaaaatt tctgccattt agaagaagag aactacattc   2160

atggtttgga agagataaac ctgaaaagaa gagtggcctt atcttcactt tatcgataag   2220

tcagtttatt tgtttcattg tgtacatttt tatattctcc ttttgacatt ataactgttg   2280

gcttttctaa tcttgttaaa tatatctatt tttaccaaag gtatttaata ttctttttta   2340

tgacaactta gatcaactat ttttagcttg gtaaattttt ctaaacacaa ttgttatagc   2400

cagaggaaca aagatgatat aaaatattgt tgctctgaca aaaatacatg tatttcattc   2460

tcgtatggtg ctagagttag attaatctgc attttaaaaa actgaattgg aatagaattg   2520

gtaagttgca aagacttttt gaaaataatt aaattatcat atcttccatt cctgttattg   2580

gagatgaaaa taaaaagcaa cttatgaaag tagacattca gatccagcca ttactaacct   2640

attccttttt tggggaaatc tgagcctagc tcagaaaaac ataaagcacc ttgaaaaaga   2700

cttggcagct tcctgataaa gcgtgctgtg ctgtgcagta ggaacacatc ctatttattg   2760

tgatgttgtg gttttattat cttaaactct gttccataca cttgtataaa tacatggata   2820

tttttatgta cagaagtatg tctcttaacc agttcactta ttgtactctg gcaatttaaa   2880

agaaaatcag taaaatattt tgcttgtaaa atgcttaata tcgtgcctag gttatgtggt   2940

gactatttga atcaaaaatg tattgaatca tcaaataaaa gaatgtggct attttgggga   3000

gaaaatt                                                             3007


<210>  42
<211>  345
<212>  PRT
<213>  Homosapiens

<400>  42

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 
        35                  40                  45              


Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 
    50                  55                  60                  


His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 
65                  70                  75                  80  


Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 
                85                  90                  95      


Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
            100                 105                 110         


Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 
        115                 120                 125             


Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 
    130                 135                 140                 


Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 
145                 150                 155                 160 


Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 
                165                 170                 175     


Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
            180                 185                 190         


Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 
        195                 200                 205             


Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 
    210                 215                 220                 


Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 
225                 230                 235                 240 


Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser 
                245                 250                 255     


Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 
            260                 265                 270         


Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 
        275                 280                 285             


His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 
    290                 295                 300                 


Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 
305                 310                 315                 320 


His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 
                325                 330                 335     


Cys Val Cys Arg Gly Ser Thr Gly Gly 
            340                 345 


<210>  43
<211>  2649
<212>  DNA
<213>  Homosapiens

<400>  43
ctgggacgca gctgcccccg ctcggcgccc gctgcaccct tagcagccac tgccacctgg     60

gcccggagcc tccacgatct cgcccggcga ttgtgggcag gggcgcctcc ggatcgatct    120

tctgaaattc aagttttcaa gatgaagttt ttattgacaa ctgccttttt aattttaatt    180

tccttgtggg tggaagaagc ctattctaag gaaaagtctt caaagaaagg gaaggggaaa    240

aagaagcagt atctatgccc atctcagcag tcagcagagg accttgcccg agtacctgcc    300

aactccacta gcaatatctt gaacaggtta ttggtcagtt atgatcccag gataagacca    360

aacttcaaag gcattcctgt tgatgtagta gtcaacattt ttattaacag ttttggatcc    420

attcaagaaa caacaatgga ctatagagtt aacatcttcc tgagacaaaa atggaatgac    480

cccaggctga agctccccag tgattttagg ggttcagatg cactgacagt ggatccaaca    540

atgtacaagt gtttatggaa acctgattta ttttttgcaa atgaaaaaag tgccaatttt    600

catgatgtga cccaggaaaa catcctcctc tttatttttc gtgatggaga tgtccttgtc    660

agcatgaggt tatctattac tctttcatgc cctttggact tgacattgtt tcccatggat    720

acacaacgtt gcaagatgca actggagagc tttggttaca caactgatga tttacgattt    780

atctggcagt caggagatcc tgtgcaatta gaaaaaattg ccttgcctca atttgatatc    840

aaaaaggaag atattgaata tggtaactgt acaaaatact ataaaggcac gggctactac    900

acatgcgtgg aagtcatctt caccctgagg aggcaggtcg gcttttacat gatgggggtc    960

tacgccccaa ccctgctcat tgttgttctc tcctggcttt ccttctggat caacccggac   1020

gcgagtgctg ccagagtgcc cctgggtatc ttctcagtcc tcagcttggc ctctgagtgc   1080

acaacccttg ccgctgagct tcccaaagtt tcctatgtga aggctcttga tgtttggctt   1140

attgcttgcc ttctctttgg gtttgcttcc ctggtggagt atgcagttgt ccaggtgatg   1200

ctgaacaacc ccaaaagggt tgaagctgaa aaagccagaa ttgctaaggc tgagcaagca   1260

gatggaaaag gtggaaatgt ggctaaaaag aatactgtga atggaacagg gactcctgtt   1320

catattagca ctttgcaggt tggtgagacc agatgcaaaa aagtttgtac ttctaagtct   1380

gatctgagat ctaatgactt cagcattgtt ggaagcttac caagagattt tgaactatcc   1440

aattatgact gctatggaaa acccattgaa gttaacaacg gacttgggaa atctcaggct   1500

aagaacaaca agaagcctcc ccctgcgaaa cctgttattc caacagcagc aaagcgaatt   1560

gatctttatg caagagcatt gtttcctttc tgcttcttgt tcttcaatgt tatatattgg   1620

tctatatatt tatgataaat cttttccatt tgtacaaaat aaaattccat ttcattgtga   1680

cctactcctt tcataaatgc caatctgtga gaacttttga attttcatag caacattgca   1740

ttttggatgc catttgattg taataaaact gtggcacctt aattttgaat ggcagcatga   1800

tcatgtaata tctgtgctct aataacgatg tatatatgta tagtgaacat attgcttagt   1860

aacaaatgaa ggacaagcat actacataat ataatccata caattctctt cagttagtgt   1920

aaactgcaaa tactacagat aattctgata ataaaatgat atgcacgctg aatcctgcta   1980

tggtcaccat tctaatgtat gtagtatttc aaatttcctt ccttgtaact ttcaaagaaa   2040

gccatcttat tcttgtaatt ttagatggta ttatcacaga tttaaaaagg ttgtattaca   2100

tattgtttaa actttgtaag tagaaatata tctgttataa ttatacaggc tctgtggaga   2160

aataaagttc aaaatatatt aatttgtaaa atcagctcgt tttaaagtgt gcttgtgttg   2220

tcaaaaatat cagatagtaa tacacagtga gcatttttaa acaaagggaa acctatattt   2280

atgtaactgt atactgaatt ctgacaaaat aaaaaaagat accttattga cgaaatattt   2340

aggataaaca aaattctatt taatccacct taaaacctaa atgtattttc atggatttca   2400

tttgttggta catattacac aaaacattgt gccttaaaat gagtcataca tcttttaaat   2460

tggaatgcag taatagatat gtgattttac atcattttta agaaaccaag gggaagtaat   2520

aagttgaaaa agaaatccat aactattaaa agattttaac ttttttattt tattaaaatg   2580

cttgcatatt ttaagtaaaa ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2640

aaaaaaaaa                                                           2649


<210>  44
<211>  497
<212>  PRT
<213>  Homosapiens

<400>  44

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  45
<211>  843
<212>  DNA
<213>  Homosapiens

<400>  45
atggcggagg tggtcatggg caaagaaaag cgccggcagc agccgctcct ctggctgccc     60

ctgtctcgca tccggacaaa gacatggcag tgcgaaggaa aagaaaacac tgacagcgat    120

ttagcaaata ctgcagagga atcagaaact tttcaatttc ttgaagatat attgccaaag    180

aagattttag ctagtaaata cccgaaaata cttaaagagg aaagagggaa aaagatgagg    240

agaatgacaa tgataatgaa agtgaccatg accaagttga atcctaaacc aaagaagtgc    300

tttaaaaacc aacctggcga aggaggactg ccctggaccc gctccactgc cgccaagaca    360

agattgaggt cctcatgtac ctgtgccaca aacagccaga gggaaagtga cccaaacagc    420

tgtccctctt tgacaggtcc gctctacagc tcagacacca agaaagcagc ggataccggc    480

agccattgcg ggctgatctg ctataagagg catgattcaa ataacacaga aaacgaattc    540

ccctttccac tgagtcttat ggaagagcaa aataaggaag atgtcaatcg cagagccttc    600

accaggttga gttccacttc agcctacaac cttgcttctg caagagcaga aagcagttac    660

taccttgctc gcttcgacag cacatgtact aaaattgtaa cgatacagag aagattagca    720

tggcccttgc gcaaggacga catgcggact cctgaagcgt tctatatttt tttgcagcaa    780

ctggtgttta caccagttgg agagaaagca ctctggctac agtattccaa ctacatgtcc    840

taa                                                                  843


<210>  46
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  46

Met Ala Glu Val Val Met Gly Lys Glu Lys Arg Arg Gln Gln Pro Leu 
1               5                   10                  15      


Leu Trp Leu Pro Leu Ser Arg Ile Arg Thr Lys Thr Trp Gln Cys Glu 
            20                  25                  30          


Gly Lys Glu Asn Thr Asp Ser Asp Leu Ala Asn Thr Ala Glu Glu Ser 
        35                  40                  45              


Glu Thr Phe Gln Phe Leu Glu Asp Ile Leu Pro Lys Lys Ile Leu Ala 
    50                  55                  60                  


Ser Lys Tyr Pro Lys Ile Leu Lys Glu Glu Arg Gly Lys Lys Met Arg 
65                  70                  75                  80  


Arg Met Thr Met Ile Met Lys Val Thr Met Thr Lys Leu Asn Pro Lys 
                85                  90                  95      


Pro Lys Lys Cys Phe Lys Asn Gln Pro Gly Glu Gly Gly Leu Pro Trp 
            100                 105                 110         


Thr Arg Ser Thr Ala Ala Lys Thr Arg Leu Arg Ser Ser Cys Thr Cys 
        115                 120                 125             


Ala Thr Asn Ser Gln Arg Glu Ser Asp Pro Asn Ser Cys Pro Ser Leu 
    130                 135                 140                 


Thr Gly Pro Leu Tyr Ser Ser Asp Thr Lys Lys Ala Ala Asp Thr Gly 
145                 150                 155                 160 


Ser His Cys Gly Leu Ile Cys Tyr Lys Arg His Asp Ser Asn Asn Thr 
                165                 170                 175     


Glu Asn Glu Phe Pro Phe Pro Leu Ser Leu Met Glu Glu Gln Asn Lys 
            180                 185                 190         


Glu Asp Val Asn Arg Arg Ala Phe Thr Arg Leu Ser Ser Thr Ser Ala 
        195                 200                 205             


Tyr Asn Leu Ala Ser Ala Arg Ala Glu Ser Ser Tyr Tyr Leu Ala Arg 
    210                 215                 220                 


Phe Asp Ser Thr Cys Thr Lys Ile Val Thr Ile Gln Arg Arg Leu Ala 
225                 230                 235                 240 


Trp Pro Leu Arg Lys Asp Asp Met Arg Thr Pro Glu Ala Phe Tyr Ile 
                245                 250                 255     


Phe Leu Gln Gln Leu Val Phe Thr Pro Val Gly Glu Lys Ala Leu Trp 
            260                 265                 270         


Leu Gln Tyr Ser Asn Tyr Met Ser 
        275                 280 


<210>  47
<211>  5644
<212>  DNA
<213>  Homosapiens

<400>  47
aggagagagg gagaagagag cgcgagagag ggtgagtgtg tgtgagtgca tgggagggtg     60

ctgaatattc cgagacactg ggaccacagc ggcagctccg ctgaaaactg cattcagcca    120

gtcctccgga cttctggagc ggggacaggg cgcagggcat cagcagccac cagcaggacc    180

tgggaaatag ggattcttct gcctccactt caggttttag cagcttggtg ctaaattgct    240

gtctcaaaat gcagaggatc taatttgcag aggaaaacag ccaaagaagg aagaggagga    300

aaaggaaaaa aaaaggggta tattgtggat gctctacttt tcttggaaat gcaaaagatt    360

atgcatattt ctgtcctcct ttctcctgtt ttatggggac tgatttttgg tgtctcttct    420

aacagcatac agataggggg gctatttcct aggggcgccg atcaagaata cagtgcattt    480

cgagtaggga tggttcagtt ttccacttcg gagttcagac tgacacccca catcgacaat    540

ttggaggtgg caaacagctt cgcagtcact aatgctttct gctcccagtt ttcgagagga    600

gtctatgcta tttttggatt ttatgacaag aagtctgtaa ataccatcac atcattttgc    660

ggaacactcc acgtctcctt catcactccc agcttcccaa cagatggcac acatccattt    720

gtcattcaga tgagacccga cctcaaagga gctctcctta gcttgattga atactatcaa    780

tgggacaagt ttgcatacct ctatgacagt gacagaggct tatcaacact gcaagctgtg    840

ctggattctg ctgctgaaaa gaaatggcaa gtgactgcta tcaatgtggg aaacattaac    900

aatgacaaga aagatgagat gtaccgatca ctttttcaag atctggagtt aaaaaaggaa    960

cggcgtgtaa ttctggactg tgaaagggat aaagtaaacg acattgtaga ccaggttatt   1020

accattggaa aacatgttaa agggtaccac tacatcattg caaatctggg atttactgat   1080

ggagacctat taaaaatcca gtttggaggt gcaaatgtct ctggatttca gatagtggac   1140

tatgatgatt cgttggtatc taaatttata gaaagatggt caacactgga agaaaaagaa   1200

taccctggag ctcacacaac aacaattaag tatacttctg ctctgaccta tgatgccgtt   1260

caagtgatga ctgaagcctt ccgcaaccta aggaagcaaa gaattgaaat ctcccgaagg   1320

gggaatgcag gagactgtct ggcaaaccca gcagtgccct ggggacaagg tgtagaaata   1380

gaaagggccc tcaaacaggt tcaggttgaa ggtctctcag gaaatataaa gtttgaccag   1440

aatggaaaaa gaataaacta tacaattaac atcatggagc tcaaaactaa tgggccccgg   1500

aagattggct actggagtga agtggacaaa atggttgtta cccttactga gctcccttct   1560

ggaaatgaca cctctgggct tgagaataag actgttgttg tcaccacaat tttggaatct   1620

ccgtatgtta tgatgaagaa aaatcatgaa atgcttgaag gcaatgagcg ctatgagggc   1680

tactgtgttg acctggctgc agaaatcgcc aaacattgtg ggttcaagta caagttgaca   1740

attgttggtg atggcaagta tggggccagg gatgcagaca cgaaaatttg gaatgggatg   1800

gttggagaac ttgtatatgg gaaagctgat attgcaattg ctccattaac tattaccctt   1860

gtgagagaag aggtgattga cttctcaaag cccttcatga gcctcgggat atctatcatg   1920

atcaagaagc ctcagaagtc caaaccagga gtgttttcct ttcttgatcc tttagcctat   1980

gagatctgga tgtgcattgt ttttgcctac attggggtca gtgtagtttt attcctggtc   2040

agcagattta gcccctacga gtggcacact gaggagtttg aagatggaag agaaacacaa   2100

agtagtgaat caactaatga atttgggatt tttaatagtc tctggttttc cttgggtgcc   2160

tttatgcggc aaggatgcga tatttcgcca agatccctct ctgggcgcat tgttggaggt   2220

gtgtggtggt tctttaccct gatcataatc tcctcctaca cggctaactt agctgccttc   2280

ctgactgtag agaggatggt gtctcccatc gaaagtgctg aggatctttc taagcaaaca   2340

gaaattgctt atggaacatt agactctggc tccactaaag agtttttcag gagatctaaa   2400

attgcagtgt ttgataaaat gtggacctac atgcggagtg cggagccctc tgtgtttgtg   2460

aggactacgg ccgaaggggt ggctagagtg cggaagtcca aagggaaata tgcctacttg   2520

ttggagtcca cgatgaacga gtacattgag caaaggaagc cttgcgacac catgaaagtt   2580

ggtggaaacc tggattccaa aggctatggc atcgcaacac ctaaaggatc ctcattaaga   2640

accccagtaa atcttgcagt attgaaactc agtgagcaag gcgtcttaga caagctgaaa   2700

aacaaatggt ggtacgataa aggtgaatgt ggagccaagg actctggaag taaggaaaag   2760

accagtgccc tcagtctgag caacgttgct ggagtattct acatccttgt cgggggcctt   2820

ggtttggcaa tgctggtggc tttgattgag ttctgttaca agtcaagggc cgaggcgaaa   2880

cgaatgaagg tggcaaagaa tgcacagaat attaacccat cttcctcgca gaattcacag   2940

aattttgcaa cttataagga aggttacaac gtatatggca tcgaaagtgt taaaatttag   3000

gggatgacct tgaatgatgc catgaggaac aaggcaaggc tgtcaattac aggaagtact   3060

ggagaaaatg gacgtgttat gactccagaa tttcccaaag cagtgcatgc tgtcccttac   3120

gtgagtcctg gcatgggaat gaatgtcagt gtgactgatc tctcgtgatt gataagaacc   3180

ttttgagtgc cttacacaat ggttttcttg tgtgtttatt gtcaaagtgg tgagaggcat   3240

ccagtatctt gaagactttt ctttcagcca agaattctta aatatgtgga gttcatcttg   3300

aattgtaagg aatgattaat taaaacacaa catctttttc tactcgagtt acagacaaag   3360

cgtggtggac atgcacagct aacatggaag tactataatt tacctgaagt ctttgtacag   3420

acaacaaacc tgtttctgca gccactattg ttagtctctt gattcataat gacttaagca   3480

cacttgacat caactgcatc aagatgtgac atgttttata aaaaaaggaa aaaaaacatt   3540

taaaactaaa aaatattttt aggtattttc acaaacaaac tggcttttaa ataaatttgc   3600

ttccatattg gttgaataag acaaaaacaa ttaaactgag tgggaagtga ataaaaaaag   3660

gctttaggta tcgattccat atttttcaaa gccaaatatg taaatgctaa ggaaagtaaa   3720

caaagaggag attccaatct tgtaatttaa tattgttatt aaaactttaa tgtatcctat   3780

tctttaacat ttggtgttaa tataaaatta cttggcaatg cttgacattt gaaataaaca   3840

tttttctatt gttttattgc aagtggtcca attaattttg cttagctaca gtttggtcat   3900

aaatcaagtg agtttaaaga cactaccaag ttgttaggtg cccagagaaa atttctccct   3960

tttaaaaagg ccaggtgatt tttcaaatgt aatcttgccc ccaaagtaat atctgaatat   4020

ctttttgaca tgtctaaata tatatatata taaagaaata tttgttaaca caaaagcatt   4080

tgatctatgt agataaatgc taatagattt aaaaagctaa tattaacaaa taccagaata   4140

cgtgaagttc catttttaaa gtgtttgagc ttacagaaga gaaacattca ttttaaatga   4200

agtaaaaaat gccttgaaag taattcttta gatagttgcc cattgattaa attccaaaaa   4260

ctaaatatgt ttttagcttt aaaattataa aagctgtcat aaactttata tattatgaat   4320

tttaaaatat gtttgagtct cctgcaatat agtttcatcc cattgacatc aattaaaaat   4380

aaccctaata tattattttt atatttattc ctcaggtgga atggctattt taatatgccc   4440

agtgtggata aaatgtcaca tttctgtaac ttttgactaa agagcctata tttatctagt   4500

taatgaattt aaaggatcta tctttccctt cataaaatac ctcttatttc cattaaagcc   4560

ccccaagttt aattaattta ggattttgaa tgattattga catccaatag ttatttttaa   4620

tatttgtatt cttgttattt ctggaagaaa gcctttgtgt agcacttggt attttgcaaa   4680

gtgcttttaa aacattctta cttaccgtat ttcatagaag ggaaggaaaa atgtaaggtt   4740

taacagtaag cacttgcatt gaacatggag gcatgtggta tcatgatatt cttcactaaa   4800

tttagctgtc cctaatcaca gatcctaagg taatataata taattttagt gcatttctcc   4860

tcatcaggaa tgctggaggt gcattttaag ttttaataat aagtgctaga atgaccaaat   4920

tgcagactaa ttgtttccat attgtactta aaatgagttt ttaaaagtga aaaagaaatg   4980

actatataca atcaatgcta tttattgtac ctctgggcct actcttctaa aaattgtagc   5040

ttatcgattt ttctctgtca agcttgaact aatgtaaata attgaaataa tgtaaagtta   5100

tattttcatg tttttataga tacaacatga caagaataca taatgtaaga gtatttcaac   5160

tatggataat gttgattgga taatgcacat ctcagttaca agcagtactc atagtttaat   5220

atccatgtaa cggtgcatca atatattgct atataaatat gtctgtgtgc atataagtga   5280

aaagtggtca aacaagagtg atgacagctg tctaaaggtt tttttattca ttttatataa   5340

aaactgttat ggaaagacca aaatgtttat gaactattct tatgtaaatt tacaattgtc   5400

ctttactgta cttttttgtt tacagtatag taccttattt tctgctgtgt taagtgggtg   5460

tcaaactcca agaagacata cactttctat aacttctatt gaagatattg gaatttccaa   5520

tttttcatgt gtactatgtc agaaaatgct ttcgatttta tttttaaatc taacatcgga   5580

tggcttttcc ggagtgttgt aaaaacttca atcatacata aaacatgttc ttacaaaagg   5640

caaa                                                                5644


<210>  48
<211>  883
<212>  PRT
<213>  Homosapiens

<400>  48

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  49
<211>  2786
<212>  DNA
<213>  Homosapiens

<400>  49
atggctgtgc gctctcgccg cccgtggatg agcgtggcat tagggctggt gctgggcttc     60

accgccgcgt cctggctcat cgcccccagg gtggcggagc tgagcgagag gaagagacgt    120

ggctccagcc tctgctccta ctacggtcgc tctgctgctg gcccccgcgc cggcgctcag    180

cagccgctcc cccagcccca gtcccgacca cggcaggagc agtcgccgcc ccccgcgcgc    240

caggatctcc aggggccacc gctgcccgag gcagcacccg ggatcaccag ttttcgaagc    300

agcccctggc agcagccacc tccgctgcag cagcggcggc gaggacgcga gcctgagggc    360

gcgacggggc ttcccggtgc tccagcggcc gagggggagc ccgaggagga ggacgggggc    420

gcggctgggc agcggagaga cggccggccg gggagtagcc acaacggcag cggggacggg    480

ggcgctgccg ccccgagcgc ccgaccccgg gacttcctgt acgtgggggt gatgaccgcg    540

cagaagtacc tgggcagccg cgcgctggcc gcgcagcgga cctgggcgcg tttcatcccg    600

ggccgcgtgg agttcttttc cagccagcag ccccccaacg ccggccagcc cccgccaccc    660

ctgcctgtca tcgcgctacc gggtgtggac gactcctatc ctccccagaa aaagtccttc    720

atgatgatca agtacatgca cgaccactac ctggacaagt atgagtggtt catgcgcgcc    780

gacgacgatg tctacatcaa aggtgacaaa ttagaagagt ttcttagatc gctaaacagc    840

agtaagcctc tctacctggg acagactggc ctggggaata ttgaagagct tggaaagctg    900

ggactggagc ctggggaaaa cttctgtatg ggaggacctg gcatgatctt tagccgagaa    960

gttctcagga ggatggtgcc acatattggt gaatgcctta gagaaatgca cacgactcat   1020

gaggatgtgg aagtaggaag atgcgttcgc cgctttggta gggctcagtg tgtgtggtct   1080

tttcagatgc aacaactgtt ccatgaaaat tatgaacaca atcggaaggg ttacatccaa   1140

gaccttcaca atagcaaaat ccatgcagcc ataacacttc atcccaacaa aaggcctgca   1200

taccaataca ggctgcataa ttacatgctc agccgcaaaa tttctgaact tcgctaccgc   1260

accatccagc tccacaggga aagtgccctg atgagcaagc tcagtaacac agaagtgagc   1320

aaagaggacc agcagctggg agtgatacct tctttcaacc acttccagcc tcgggagaga   1380

aatgaagtga tagaatggga gttcctgaca gggaagcttc tatactcagc agctgagaac   1440

cagccccctc gacagagcct cagtagcatt ttaagaacag cactggatga taccgtccta   1500

caggtgatgg agatgatcaa tgagaatgcc aagagcagag gacggctcat tgacttcaag   1560

gaaattcagt atggctaccg cagagttaac cccatgcacg gggtggagta cattttggat   1620

ttactccttt tatacaaaag acacaaggga aggaaactga ctgtgccagt gagacgtcat   1680

gcctatcttc agcagttgtt cagcaagcct ttcttcagag agaccgaaga gctagatgtc   1740

aacagtcttg tggagagtat taacagtgaa actcagtcat tctcctttat atctaattct   1800

ttaaagatat tatcttcttt tcaaggtgcc aaagaaatgg gagggcacaa tgaaaagaaa   1860

gtacacattc tcgttcctct catcggaagg tatgacattt tcttgagatt catggagaac   1920

tttgaaaaca tgtgtcttat cccaaagcag aatgtaaagt tggtcattat ccttttcagt   1980

agggattctg gccaagactc cagcaagcat attgagctga taaaagggta ccagaacaag   2040

taccccaaag cagaaatgac cctgatccca atgaagggag agttttccag aggtcttggt   2100

cttgaaatgg cttctgccca gtttgacaat gacactttgc tgctattttg tgatgttgac   2160

ttgatcttca gagaagattt tctccaacga tgtagagaca atacaattca gggacaacag   2220

gtgtactatc ccatcatctt tagccagtat gacccaaagg taacaaacgg gggaaatcct   2280

cccactgatg attacttcat attctcaaaa aagactggat tttggagaga ctatggatat   2340

ggcatcacct gtatttacaa aagtgatctt ctaggtgcag gtggatttga tacctcaata   2400

caaggctggg gactagaaga tgtagatctc tacaataaag tcattctatc tggcttaagg   2460

ccattcagaa gccaagaagt aggagtggtg catattttcc atccagttca ttgtgatcct   2520

aacttggacc ctaagcagta taagatgtgc ttaggatcca aggcaagtac tttcgcctca   2580

accatgcaac tggctgaact ctggcttgaa aaacatttag gtgtcaggta caatcgaact   2640

ctctcctgac agtccaggca acacattttg ccttttttaa ggggagttta cctcattgtt   2700

ggttgttgtt atttttattg tattattgtt attttattat tattattgtt ataattttat   2760

tttgttgtcc tggtcttaaa ctactc                                        2786


<210>  50
<211>  882
<212>  PRT
<213>  Homosapiens

<400>  50

Met Ala Val Arg Ser Arg Arg Pro Trp Met Ser Val Ala Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Thr Ala Ala Ser Trp Leu Ile Ala Pro Arg Val Ala 
            20                  25                  30          


Glu Leu Ser Glu Arg Lys Arg Arg Gly Ser Ser Leu Cys Ser Tyr Tyr 
        35                  40                  45              


Gly Arg Ser Ala Ala Gly Pro Arg Ala Gly Ala Gln Gln Pro Leu Pro 
    50                  55                  60                  


Gln Pro Gln Ser Arg Pro Arg Gln Glu Gln Ser Pro Pro Pro Ala Arg 
65                  70                  75                  80  


Gln Asp Leu Gln Gly Pro Pro Leu Pro Glu Ala Ala Pro Gly Ile Thr 
                85                  90                  95      


Ser Phe Arg Ser Ser Pro Trp Gln Gln Pro Pro Pro Leu Gln Gln Arg 
            100                 105                 110         


Arg Arg Gly Arg Glu Pro Glu Gly Ala Thr Gly Leu Pro Gly Ala Pro 
        115                 120                 125             


Ala Ala Glu Gly Glu Pro Glu Glu Glu Asp Gly Gly Ala Ala Gly Gln 
    130                 135                 140                 


Arg Arg Asp Gly Arg Pro Gly Ser Ser His Asn Gly Ser Gly Asp Gly 
145                 150                 155                 160 


Gly Ala Ala Ala Pro Ser Ala Arg Pro Arg Asp Phe Leu Tyr Val Gly 
                165                 170                 175     


Val Met Thr Ala Gln Lys Tyr Leu Gly Ser Arg Ala Leu Ala Ala Gln 
            180                 185                 190         


Arg Thr Trp Ala Arg Phe Ile Pro Gly Arg Val Glu Phe Phe Ser Ser 
        195                 200                 205             


Gln Gln Pro Pro Asn Ala Gly Gln Pro Pro Pro Pro Leu Pro Val Ile 
    210                 215                 220                 


Ala Leu Pro Gly Val Asp Asp Ser Tyr Pro Pro Gln Lys Lys Ser Phe 
225                 230                 235                 240 


Met Met Ile Lys Tyr Met His Asp His Tyr Leu Asp Lys Tyr Glu Trp 
                245                 250                 255     


Phe Met Arg Ala Asp Asp Asp Val Tyr Ile Lys Gly Asp Lys Leu Glu 
            260                 265                 270         


Glu Phe Leu Arg Ser Leu Asn Ser Ser Lys Pro Leu Tyr Leu Gly Gln 
        275                 280                 285             


Thr Gly Leu Gly Asn Ile Glu Glu Leu Gly Lys Leu Gly Leu Glu Pro 
    290                 295                 300                 


Gly Glu Asn Phe Cys Met Gly Gly Pro Gly Met Ile Phe Ser Arg Glu 
305                 310                 315                 320 


Val Leu Arg Arg Met Val Pro His Ile Gly Glu Cys Leu Arg Glu Met 
                325                 330                 335     


His Thr Thr His Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe 
            340                 345                 350         


Gly Arg Ala Gln Cys Val Trp Ser Phe Gln Met Gln Gln Leu Phe His 
        355                 360                 365             


Glu Asn Tyr Glu His Asn Arg Lys Gly Tyr Ile Gln Asp Leu His Asn 
    370                 375                 380                 


Ser Lys Ile His Ala Ala Ile Thr Leu His Pro Asn Lys Arg Pro Ala 
385                 390                 395                 400 


Tyr Gln Tyr Arg Leu His Asn Tyr Met Leu Ser Arg Lys Ile Ser Glu 
                405                 410                 415     


Leu Arg Tyr Arg Thr Ile Gln Leu His Arg Glu Ser Ala Leu Met Ser 
            420                 425                 430         


Lys Leu Ser Asn Thr Glu Val Ser Lys Glu Asp Gln Gln Leu Gly Val 
        435                 440                 445             


Ile Pro Ser Phe Asn His Phe Gln Pro Arg Glu Arg Asn Glu Val Ile 
    450                 455                 460                 


Glu Trp Glu Phe Leu Thr Gly Lys Leu Leu Tyr Ser Ala Ala Glu Asn 
465                 470                 475                 480 


Gln Pro Pro Arg Gln Ser Leu Ser Ser Ile Leu Arg Thr Ala Leu Asp 
                485                 490                 495     


Asp Thr Val Leu Gln Val Met Glu Met Ile Asn Glu Asn Ala Lys Ser 
            500                 505                 510         


Arg Gly Arg Leu Ile Asp Phe Lys Glu Ile Gln Tyr Gly Tyr Arg Arg 
        515                 520                 525             


Val Asn Pro Met His Gly Val Glu Tyr Ile Leu Asp Leu Leu Leu Leu 
    530                 535                 540                 


Tyr Lys Arg His Lys Gly Arg Lys Leu Thr Val Pro Val Arg Arg His 
545                 550                 555                 560 


Ala Tyr Leu Gln Gln Leu Phe Ser Lys Pro Phe Phe Arg Glu Thr Glu 
                565                 570                 575     


Glu Leu Asp Val Asn Ser Leu Val Glu Ser Ile Asn Ser Glu Thr Gln 
            580                 585                 590         


Ser Phe Ser Phe Ile Ser Asn Ser Leu Lys Ile Leu Ser Ser Phe Gln 
        595                 600                 605             


Gly Ala Lys Glu Met Gly Gly His Asn Glu Lys Lys Val His Ile Leu 
    610                 615                 620                 


Val Pro Leu Ile Gly Arg Tyr Asp Ile Phe Leu Arg Phe Met Glu Asn 
625                 630                 635                 640 


Phe Glu Asn Met Cys Leu Ile Pro Lys Gln Asn Val Lys Leu Val Ile 
                645                 650                 655     


Ile Leu Phe Ser Arg Asp Ser Gly Gln Asp Ser Ser Lys His Ile Glu 
            660                 665                 670         


Leu Ile Lys Gly Tyr Gln Asn Lys Tyr Pro Lys Ala Glu Met Thr Leu 
        675                 680                 685             


Ile Pro Met Lys Gly Glu Phe Ser Arg Gly Leu Gly Leu Glu Met Ala 
    690                 695                 700                 


Ser Ala Gln Phe Asp Asn Asp Thr Leu Leu Leu Phe Cys Asp Val Asp 
705                 710                 715                 720 


Leu Ile Phe Arg Glu Asp Phe Leu Gln Arg Cys Arg Asp Asn Thr Ile 
                725                 730                 735     


Gln Gly Gln Gln Val Tyr Tyr Pro Ile Ile Phe Ser Gln Tyr Asp Pro 
            740                 745                 750         


Lys Val Thr Asn Gly Gly Asn Pro Pro Thr Asp Asp Tyr Phe Ile Phe 
        755                 760                 765             


Ser Lys Lys Thr Gly Phe Trp Arg Asp Tyr Gly Tyr Gly Ile Thr Cys 
    770                 775                 780                 


Ile Tyr Lys Ser Asp Leu Leu Gly Ala Gly Gly Phe Asp Thr Ser Ile 
785                 790                 795                 800 


Gln Gly Trp Gly Leu Glu Asp Val Asp Leu Tyr Asn Lys Val Ile Leu 
                805                 810                 815     


Ser Gly Leu Arg Pro Phe Arg Ser Gln Glu Val Gly Val Val His Ile 
            820                 825                 830         


Phe His Pro Val His Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys 
        835                 840                 845             


Met Cys Leu Gly Ser Lys Ala Ser Thr Phe Ala Ser Thr Met Gln Leu 
    850                 855                 860                 


Ala Glu Leu Trp Leu Glu Lys His Leu Gly Val Arg Tyr Asn Arg Thr 
865                 870                 875                 880 


Leu Ser 
        


<210>  51
<211>  2391
<212>  DNA
<213>  Homosapiens

<400>  51
tcaaaagtgg cgggtgtggc gcggggctgg tagcggccgg agccgtgcga gttctctacc     60

ctgcttcgcg agcgggcgag agaacgcgag tcccaggatc cccggcaccc agttctcttc    120

cactgcattc ccccggcgcg tgtgggaccg aggtggacat ggatccgcag aggtcccccc    180

tattggaagt aaaggggaac atagaactga agagacctct gattaaggcc ccttcccagc    240

tgcctctctc aggaagcaga ctcaagagga ggcctgacca gatggaagat ggcctggagc    300

ctgagaagaa acggacaaga ggcctgggtg caacgaccaa aattaccaca tcccacccaa    360

gagttccatc cctcactaca gtgccacaga cacaaggcca gaccacagct caaaaagttt    420

ccaagaagac aggaccccgg tgttccacag ctattgccac agggttgaag aaccagaagc    480

cagttcctgc tgttcctgtc cagaagtctg gcacatcagg tgttcctccc atggcaggag    540

ggaagaaacc cagcaaacgt ccagcctggg acttaaaggg tcagttatgt gacctaaatg    600

cagaactaaa acggtgccgt gagaggactc aaacgttgga ccaagagaac cagcagcttc    660

aggaccagct cagagatgcc cagcagcagg tcaaggccct ggggacagag cgcacaacac    720

tggaggggca tttagccaag gtacaggccc aggctgagca gggccaacag gagctgaaga    780

acttgcgtgc ttgtgtcctg gagctggaag agcggctgag cacgcaggag ggcttggtgc    840

aagagcttca gaaaaaacag gtggaattgc aggaagaacg gaggggactg atgtcccaac    900

tagaggagaa ggagaggagg ctgcagacat cagaagcagc cctgtcaagc agccaagcag    960

aggtggcatc tctgcggcag gagactgtgg cccaggcagc cttactgact gagcgggaag   1020

aacgtcttca tgggctagaa atggagcgcc ggcgactgca caaccagctg caggaactca   1080

agggcaacat ccgtgtattc tgccgggtcc gccctgtcct gccgggggag cccactccac   1140

cccctggcct cctcctgttt ccctctggcc ctggtgggcc ctctgatcct ccaacccgcc   1200

ttagcctctc ccggtctgac gagcggcgtg ggaccctgag tggggcacca gctcccccac   1260

ctcgccatga tttttccttt gaccgggtat tcccaccagg aagtggacag gatgaagtgt   1320

ttgaagagat tgccatgctt gtccagtcag ccctggatgg ctatccagta tgcatctttg   1380

cctatggcca gacaggcagt ggcaagacct tcacaatgga gggtgggcct gggggagacc   1440

cccagttgga ggggctgatc cctcgggccc tgcggcacct cttctctgtg gctcaggagc   1500

tgagtggtca gggctggacc tacagctttg tagcaagcta cgtagagatc tacaatgaga   1560

ctgtccggga cctgctggcc actggaaccc ggaagggtca agggggcgag tgtgagattc   1620

gccgtgcagg gccagggagt gaggagctca ctgtcaccaa tgctcgatat gtccctgtct   1680

cctgtgagaa agaagtggac gccctgcttc atctggcccg ccagaatcgg gctgtggccc   1740

gcacagccca gaatgaacgg tcatcacgca gccacagtgt attccagcta cagatttctg   1800

gggagcactc cagccgaggc ctgcagtgtg gggcccccct cagtcttgtg gacctggccg   1860

ggagtgagcg acttgacccc ggcttagccc tcggccccgg ggagcgggaa cgccttcggg   1920

aaacacaggc cattaacagc agcctgtcca cgctggggct ggttatcatg gccctgagca   1980

acaaggagtc ccacgtgcct taccggaaca gcaaactgac ctacctgctg cagaactctc   2040

tgggtggtag tgctaagatg ctcatgtttg tgaacatttc tccactggaa gagaacgtct   2100

ccgagtccct caactctcta cgctttgcct ccaaggtgaa ccagtgtgtt attggtactg   2160

ctcaggccaa caggaagtga agacggatcc agatctgtgt gtgtgtgtgt gtgtgtgtgt   2220

gtgtgtgtgt gtgtgtgtgt gtgtgtgtcc ctatgtctat gtatcgggtg aggggtggga   2280

gggttgctgg agggtgcttt attgggtgga gggcaccatg tcccagggct atcaaataaa   2340

gaatagtttg gttttttttt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            2391


<210>  52
<211>  673
<212>  PRT
<213>  Homosapiens

<400>  52

Met Asp Pro Gln Arg Ser Pro Leu Leu Glu Val Lys Gly Asn Ile Glu 
1               5                   10                  15      


Leu Lys Arg Pro Leu Ile Lys Ala Pro Ser Gln Leu Pro Leu Ser Gly 
            20                  25                  30          


Ser Arg Leu Lys Arg Arg Pro Asp Gln Met Glu Asp Gly Leu Glu Pro 
        35                  40                  45              


Glu Lys Lys Arg Thr Arg Gly Leu Gly Ala Thr Thr Lys Ile Thr Thr 
    50                  55                  60                  


Ser His Pro Arg Val Pro Ser Leu Thr Thr Val Pro Gln Thr Gln Gly 
65                  70                  75                  80  


Gln Thr Thr Ala Gln Lys Val Ser Lys Lys Thr Gly Pro Arg Cys Ser 
                85                  90                  95      


Thr Ala Ile Ala Thr Gly Leu Lys Asn Gln Lys Pro Val Pro Ala Val 
            100                 105                 110         


Pro Val Gln Lys Ser Gly Thr Ser Gly Val Pro Pro Met Ala Gly Gly 
        115                 120                 125             


Lys Lys Pro Ser Lys Arg Pro Ala Trp Asp Leu Lys Gly Gln Leu Cys 
    130                 135                 140                 


Asp Leu Asn Ala Glu Leu Lys Arg Cys Arg Glu Arg Thr Gln Thr Leu 
145                 150                 155                 160 


Asp Gln Glu Asn Gln Gln Leu Gln Asp Gln Leu Arg Asp Ala Gln Gln 
                165                 170                 175     


Gln Val Lys Ala Leu Gly Thr Glu Arg Thr Thr Leu Glu Gly His Leu 
            180                 185                 190         


Ala Lys Val Gln Ala Gln Ala Glu Gln Gly Gln Gln Glu Leu Lys Asn 
        195                 200                 205             


Leu Arg Ala Cys Val Leu Glu Leu Glu Glu Arg Leu Ser Thr Gln Glu 
    210                 215                 220                 


Gly Leu Val Gln Glu Leu Gln Lys Lys Gln Val Glu Leu Gln Glu Glu 
225                 230                 235                 240 


Arg Arg Gly Leu Met Ser Gln Leu Glu Glu Lys Glu Arg Arg Leu Gln 
                245                 250                 255     


Thr Ser Glu Ala Ala Leu Ser Ser Ser Gln Ala Glu Val Ala Ser Leu 
            260                 265                 270         


Arg Gln Glu Thr Val Ala Gln Ala Ala Leu Leu Thr Glu Arg Glu Glu 
        275                 280                 285             


Arg Leu His Gly Leu Glu Met Glu Arg Arg Arg Leu His Asn Gln Leu 
    290                 295                 300                 


Gln Glu Leu Lys Gly Asn Ile Arg Val Phe Cys Arg Val Arg Pro Val 
305                 310                 315                 320 


Leu Pro Gly Glu Pro Thr Pro Pro Pro Gly Leu Leu Leu Phe Pro Ser 
                325                 330                 335     


Gly Pro Gly Gly Pro Ser Asp Pro Pro Thr Arg Leu Ser Leu Ser Arg 
            340                 345                 350         


Ser Asp Glu Arg Arg Gly Thr Leu Ser Gly Ala Pro Ala Pro Pro Pro 
        355                 360                 365             


Arg His Asp Phe Ser Phe Asp Arg Val Phe Pro Pro Gly Ser Gly Gln 
    370                 375                 380                 


Asp Glu Val Phe Glu Glu Ile Ala Met Leu Val Gln Ser Ala Leu Asp 
385                 390                 395                 400 


Gly Tyr Pro Val Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys 
                405                 410                 415     


Thr Phe Thr Met Glu Gly Gly Pro Gly Gly Asp Pro Gln Leu Glu Gly 
            420                 425                 430         


Leu Ile Pro Arg Ala Leu Arg His Leu Phe Ser Val Ala Gln Glu Leu 
        435                 440                 445             


Ser Gly Gln Gly Trp Thr Tyr Ser Phe Val Ala Ser Tyr Val Glu Ile 
    450                 455                 460                 


Tyr Asn Glu Thr Val Arg Asp Leu Leu Ala Thr Gly Thr Arg Lys Gly 
465                 470                 475                 480 


Gln Gly Gly Glu Cys Glu Ile Arg Arg Ala Gly Pro Gly Ser Glu Glu 
                485                 490                 495     


Leu Thr Val Thr Asn Ala Arg Tyr Val Pro Val Ser Cys Glu Lys Glu 
            500                 505                 510         


Val Asp Ala Leu Leu His Leu Ala Arg Gln Asn Arg Ala Val Ala Arg 
        515                 520                 525             


Thr Ala Gln Asn Glu Arg Ser Ser Arg Ser His Ser Val Phe Gln Leu 
    530                 535                 540                 


Gln Ile Ser Gly Glu His Ser Ser Arg Gly Leu Gln Cys Gly Ala Pro 
545                 550                 555                 560 


Leu Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Asp Pro Gly Leu 
                565                 570                 575     


Ala Leu Gly Pro Gly Glu Arg Glu Arg Leu Arg Glu Thr Gln Ala Ile 
            580                 585                 590         


Asn Ser Ser Leu Ser Thr Leu Gly Leu Val Ile Met Ala Leu Ser Asn 
        595                 600                 605             


Lys Glu Ser His Val Pro Tyr Arg Asn Ser Lys Leu Thr Tyr Leu Leu 
    610                 615                 620                 


Gln Asn Ser Leu Gly Gly Ser Ala Lys Met Leu Met Phe Val Asn Ile 
625                 630                 635                 640 


Ser Pro Leu Glu Glu Asn Val Ser Glu Ser Leu Asn Ser Leu Arg Phe 
                645                 650                 655     


Ala Ser Lys Val Asn Gln Cys Val Ile Gly Thr Ala Gln Ala Asn Arg 
            660                 665                 670         


Lys 
    


<210>  53
<211>  2008
<212>  DNA
<213>  Homosapiens

<400>  53
gcccctgccc ggctcccggc ggccccagct gtcaccggcc cccccaggat gcaatggcgc     60

agcccccccg gctgagccgc tctggtgcct cctcactttg ggacccagct tctcctgctc    120

ccacctctgg ccccaggcct cggctttggg agggtcaaga tgtgctggcc agatggactg    180

atgggctgct atacttgggt accatcaaaa aggtggacag tgctagggag gtgtgtctgg    240

tccagtttga ggatgattcg cagtttctgg ttctatggaa agacattagc cctgctgccc    300

tccctggaga ggaactcctc tgttgtgtct gtcgctctga gactgtggtc cctgggaacc    360

ggctggtcag ctgtgagaag tgtcgccatg cttatcacca ggactgccat gttcccaggg    420

ctccagcccc tggagaggga gagggcacat cctgggtatg ccgccagtgt gtctttgcga    480

tcgccaccaa gaggggaggt gccctgaaga agggccccta tgcccgggcc atgctgggta    540

tgaagctttc tctgccatat ggactgaagg ggctggactg ggatgctgga catctgagca    600

accgacagca gagttactgt tactgtggtg gccctgggga gtggaacctg aaaatgctgc    660

agtgccggag ctgcctgcag tggttccatg aggcctgcac ccagtgtctg agcaagcccc    720

tcctctatgg ggacaggttc tatgaatttg aatgctgtgt gtgtcgcggg ggccctgaga    780

aagtccggag actacagctt cgctgggtgg atgtggccca tcttgtcctg tatcacctca    840

gtgtttgctg taagaagaaa tactttgatt ttgatcgtga gatcctcccc ttcacttctg    900

agaattggga cagtttgctc ctgggggagc tttcagacac ccccaaagga gaacgttctt    960

ccaagctcct ctctgctctt aacagccaca aggaccgttt catttcaggg agagagatta   1020

agaagaggaa atgtttgttt ggtctccatg ctcggatgcc tccccctgtg gagcccccta   1080

ctggagatgg agcactcacc agggcagggc cctgggggag gggtctcacg tcccctgggg   1140

aagcgccgga ggccggagcc agagcccctg aggaggaggc agaaggggaa agtggaggag   1200

ctggggccac cctcagcagt gcgcaatcag cccgagcccc aggagcagag ggagcgggct   1260

catctgcaga gggcactgca gcagccccat ccggatgttt gcttccttcc acccttctgc   1320

cagcaccgca gggacctctg gggacagtgg acccccagac aggtcacccc tggaacttca   1380

cattggtttc cccacagaca tccctaaaag tgccccccac tcgatgactg cctcatcttc   1440

ctcagtttca tccccatccc caggtcttcc tagacgctca gcaccccctt ctcccctgtg   1500

ccgtagtttg tctcctggga ctgggggagg agtccgaggt ggggttggtt acctgtcccg   1560

aggggaccct gtccgggtcc ttgctcggag agtacggcct gatggctctg tgcagtacct   1620

ggttgagtgg ggaggagggg gcatcttctg aacagcctgc ctctgcccag ctccccattc   1680

acacacaccg gcactttcat accctgacct ctgacctcac ctacagctgg gatgtacctg   1740

gagagatagg gggtagttct ccctactgcc caggctggaa tccaagagtg gggagtgggg   1800

aagaggccct cttctctacc ctccttcatg attcctgacc cctcccatcc ttcccatttc   1860

ctttgatgtt attttgttac agctttttaa atatttttta aaattattta acccctgggg   1920

gcagagactg aggagggagg atgataaggg atcccggact ctgtatgatt gaaataaaga   1980

gaaataaaca aaaaaaaaaa aaaaaaaa                                      2008


<210>  54
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  54

Met Ala Gln Pro Pro Arg Leu Ser Arg Ser Gly Ala Ser Ser Leu Trp 
1               5                   10                  15      


Asp Pro Ala Ser Pro Ala Pro Thr Ser Gly Pro Arg Pro Arg Leu Trp 
            20                  25                  30          


Glu Gly Gln Asp Val Leu Ala Arg Trp Thr Asp Gly Leu Leu Tyr Leu 
        35                  40                  45              


Gly Thr Ile Lys Lys Val Asp Ser Ala Arg Glu Val Cys Leu Val Gln 
    50                  55                  60                  


Phe Glu Asp Asp Ser Gln Phe Leu Val Leu Trp Lys Asp Ile Ser Pro 
65                  70                  75                  80  


Ala Ala Leu Pro Gly Glu Glu Leu Leu Cys Cys Val Cys Arg Ser Glu 
                85                  90                  95      


Thr Val Val Pro Gly Asn Arg Leu Val Ser Cys Glu Lys Cys Arg His 
            100                 105                 110         


Ala Tyr His Gln Asp Cys His Val Pro Arg Ala Pro Ala Pro Gly Glu 
        115                 120                 125             


Gly Glu Gly Thr Ser Trp Val Cys Arg Gln Cys Val Phe Ala Ile Ala 
    130                 135                 140                 


Thr Lys Arg Gly Gly Ala Leu Lys Lys Gly Pro Tyr Ala Arg Ala Met 
145                 150                 155                 160 


Leu Gly Met Lys Leu Ser Leu Pro Tyr Gly Leu Lys Gly Leu Asp Trp 
                165                 170                 175     


Asp Ala Gly His Leu Ser Asn Arg Gln Gln Ser Tyr Cys Tyr Cys Gly 
            180                 185                 190         


Gly Pro Gly Glu Trp Asn Leu Lys Met Leu Gln Cys Arg Ser Cys Leu 
        195                 200                 205             


Gln Trp Phe His Glu Ala Cys Thr Gln Cys Leu Ser Lys Pro Leu Leu 
    210                 215                 220                 


Tyr Gly Asp Arg Phe Tyr Glu Phe Glu Cys Cys Val Cys Arg Gly Gly 
225                 230                 235                 240 


Pro Glu Lys Val Arg Arg Leu Gln Leu Arg Trp Val Asp Val Ala His 
                245                 250                 255     


Leu Val Leu Tyr His Leu Ser Val Cys Cys Lys Lys Lys Tyr Phe Asp 
            260                 265                 270         


Phe Asp Arg Glu Ile Leu Pro Phe Thr Ser Glu Asn Trp Asp Ser Leu 
        275                 280                 285             


Leu Leu Gly Glu Leu Ser Asp Thr Pro Lys Gly Glu Arg Ser Ser Lys 
    290                 295                 300                 


Leu Leu Ser Ala Leu Asn Ser His Lys Asp Arg Phe Ile Ser Gly Arg 
305                 310                 315                 320 


Glu Ile Lys Lys Arg Lys Cys Leu Phe Gly Leu His Ala Arg Met Pro 
                325                 330                 335     


Pro Pro Val Glu Pro Pro Thr Gly Asp Gly Ala Leu Thr Arg Ala Gly 
            340                 345                 350         


Pro Trp Gly Arg Gly Leu Thr Ser Pro Gly Glu Ala Pro Glu Ala Gly 
        355                 360                 365             


Ala Arg Ala Pro Glu Glu Glu Ala Glu Gly Glu Ser Gly Gly Ala Gly 
    370                 375                 380                 


Ala Thr Leu Ser Ser Ala Gln Ser Ala Arg Ala Pro Gly Ala Glu Gly 
385                 390                 395                 400 


Ala Gly Ser Ser Ala Glu Gly Thr Ala Ala Ala Pro Ser Gly Cys Leu 
                405                 410                 415     


Leu Pro Ser Thr Leu Leu Pro Ala Pro Gln Gly Pro Leu Gly Thr Val 
            420                 425                 430         


Asp Pro Gln Thr Gly His Pro Trp Asn Phe Thr Leu Val Ser Pro Gln 
        435                 440                 445             


Thr Ser Leu Lys Val Pro Pro Thr Arg 
    450                 455         


<210>  55
<211>  2260
<212>  DNA
<213>  Homosapiens

<400>  55
ctcctcctgc cgctgccgct gctttggctg ctgcgtcata cgccccagag ccgccgggac     60

ggaggggctg ggcctgggga ccccccggcc tccgcctgca cgccccccca cgcccggacg    120

tgccctctcc gcgcggggga ctcgcctagg tctcctacgt ctgcccctgc ccggctcccg    180

gcggccccag ctgtcaccgg cccccccagg atgcaatggc gcagcccccc cggctgagcc    240

gctctggtgc ctcctcactt tgggacccag cttctcctgc tcccacctct ggccccaggc    300

ctcggctttg ggagggtcaa gatgtgctgg ccagatggac tgatgggctg ctatacttgg    360

gtaccatcaa aaaggtggac agtgctaggg aggtgtgtct ggtccagttt gaggatgatt    420

cgcagtttct ggttctatgg aaagacatta gccctgctgc cctccctgga gaggaactcc    480

tctgttgtgt ctgtcgctct gagactgtgg tccctgggaa ccggctggtc agctgtgaga    540

agtgtcgcca tgcttatcac caggactgcc atgttcccag ggctccagcc cctggagagg    600

gagagggcac atcctgggta tgccgccagt gtgtctttgc gatcgccacc aagaggggag    660

gtgccctgaa gaagggcccc tatgcccggg ccatgctggg tatgaagctt tctctgccat    720

atggactgaa ggggctggac tgggatgctg gacatctgag caaccgacag cagagttact    780

gttactgtgg tggccctggg gagtggaacc tgaaaatgct gcagtgccgg agctgcctgc    840

agtggttcca tgaggcctgc acccagtgtc tgagcaagcc cctcctctat ggggacaggt    900

tctatgaatt tgaatgctgt gtgtgtcgcg ggggccctga gaaagtccgg agactacagc    960

ttcgctgggt ggatgtggcc catcttgtcc tgtatcacct cagtgtttgc tgtaagaaga   1020

aatactttga ttttgatcgt gagatcctcc ccttcacttc tgagaattgg gacagtttgc   1080

tcctggggga gctttcagac acccccaaag gagaacgttc ttccaagctc ctctctgctc   1140

ttaacagcca caaggaccgt ttcatttcag ggagagagat taagaagagg aaatgtttgt   1200

ttggtctcca tgctcggatg cctccccctg tggagccccc tactggagat ggagcactca   1260

ccagcttccc ttcagggcag ggccctgggg gaggggtctc acgtcccctg gggaagcgcc   1320

ggaggccgga gccagagccc ctgaggagga ggcagaaggg gaaagtggag gagctggggc   1380

caccctcagc agtgcgcaat cagcccgagc cccaggagca gagggagcgg gctcatctgc   1440

agagggcact gcaggcctca gtgtctccac catcccccag ccctaaccag agttaccagg   1500

gcagcagcgg ctacaacttc cggcccacag atgcccgctg cctgcccagc agccccatcc   1560

ggatgtttgc ttccttccac ccttctgcca gcaccgcagg gacctctggg gacagtggac   1620

ccccagacag gtcacccctg gaacttcaca ttggtttccc cacagacatc cctaaaagtg   1680

ccccccactc gatgactgcc tcatcttcct cagtttcatc cccatcccca ggtcttccta   1740

gacgctcagc acccccttct cccctgtgcc gtagtttgtc tcctgggact gggggaggag   1800

tccgaggtgg ggttggttac ctgtcccgag gggaccctgt ccgggtcctt gctcggagag   1860

tacggcctga tggctctgtg cagtacctgg ttgagtgggg aggagggggc atcttctgaa   1920

cagcctgcct ctgcccagct ccccattcac acacaccggc actttcatac cctgacctct   1980

gacctcacct acagctggga tgtacctgga gagatagggg gtagttctcc ctactgccca   2040

ggctggaatc caagagtggg gagtggggaa gaggccctct tctctaccct ccttcatgat   2100

tcctgacccc tcccatcctt cccatttcct ttgatgttat tttgttacag ctttttaaat   2160

attttttaaa attatttaac ccctgggggc agagactgag gagggaggat gataagggat   2220

cccggactct gtatgattga aataaagaga aataaacaaa                         2260


<210>  56
<211>  567
<212>  PRT
<213>  Homosapiens

<400>  56

Met Ala Gln Pro Pro Arg Leu Ser Arg Ser Gly Ala Ser Ser Leu Trp 
1               5                   10                  15      


Asp Pro Ala Ser Pro Ala Pro Thr Ser Gly Pro Arg Pro Arg Leu Trp 
            20                  25                  30          


Glu Gly Gln Asp Val Leu Ala Arg Trp Thr Asp Gly Leu Leu Tyr Leu 
        35                  40                  45              


Gly Thr Ile Lys Lys Val Asp Ser Ala Arg Glu Val Cys Leu Val Gln 
    50                  55                  60                  


Phe Glu Asp Asp Ser Gln Phe Leu Val Leu Trp Lys Asp Ile Ser Pro 
65                  70                  75                  80  


Ala Ala Leu Pro Gly Glu Glu Leu Leu Cys Cys Val Cys Arg Ser Glu 
                85                  90                  95      


Thr Val Val Pro Gly Asn Arg Leu Val Ser Cys Glu Lys Cys Arg His 
            100                 105                 110         


Ala Tyr His Gln Asp Cys His Val Pro Arg Ala Pro Ala Pro Gly Glu 
        115                 120                 125             


Gly Glu Gly Thr Ser Trp Val Cys Arg Gln Cys Val Phe Ala Ile Ala 
    130                 135                 140                 


Thr Lys Arg Gly Gly Ala Leu Lys Lys Gly Pro Tyr Ala Arg Ala Met 
145                 150                 155                 160 


Leu Gly Met Lys Leu Ser Leu Pro Tyr Gly Leu Lys Gly Leu Asp Trp 
                165                 170                 175     


Asp Ala Gly His Leu Ser Asn Arg Gln Gln Ser Tyr Cys Tyr Cys Gly 
            180                 185                 190         


Gly Pro Gly Glu Trp Asn Leu Lys Met Leu Gln Cys Arg Ser Cys Leu 
        195                 200                 205             


Gln Trp Phe His Glu Ala Cys Thr Gln Cys Leu Ser Lys Pro Leu Leu 
    210                 215                 220                 


Tyr Gly Asp Arg Phe Tyr Glu Phe Glu Cys Cys Val Cys Arg Gly Gly 
225                 230                 235                 240 


Pro Glu Lys Val Arg Arg Leu Gln Leu Arg Trp Val Asp Val Ala His 
                245                 250                 255     


Leu Val Leu Tyr His Leu Ser Val Cys Cys Lys Lys Lys Tyr Phe Asp 
            260                 265                 270         


Phe Asp Arg Glu Ile Leu Pro Phe Thr Ser Glu Asn Trp Asp Ser Leu 
        275                 280                 285             


Leu Leu Gly Glu Leu Ser Asp Thr Pro Lys Gly Glu Arg Ser Ser Lys 
    290                 295                 300                 


Leu Leu Ser Ala Leu Asn Ser His Lys Asp Arg Phe Ile Ser Gly Arg 
305                 310                 315                 320 


Glu Ile Lys Lys Arg Lys Cys Leu Phe Gly Leu His Ala Arg Met Pro 
                325                 330                 335     


Pro Pro Val Glu Pro Pro Thr Gly Asp Gly Ala Leu Thr Ser Phe Pro 
            340                 345                 350         


Ser Gly Gln Gly Pro Gly Gly Gly Val Ser Arg Pro Leu Gly Lys Arg 
        355                 360                 365             


Arg Arg Pro Glu Pro Glu Pro Leu Arg Arg Arg Gln Lys Gly Lys Val 
    370                 375                 380                 


Glu Glu Leu Gly Pro Pro Ser Ala Val Arg Asn Gln Pro Glu Pro Gln 
385                 390                 395                 400 


Glu Gln Arg Glu Arg Ala His Leu Gln Arg Ala Leu Gln Ala Ser Val 
                405                 410                 415     


Ser Pro Pro Ser Pro Ser Pro Asn Gln Ser Tyr Gln Gly Ser Ser Gly 
            420                 425                 430         


Tyr Asn Phe Arg Pro Thr Asp Ala Arg Cys Leu Pro Ser Ser Pro Ile 
        435                 440                 445             


Arg Met Phe Ala Ser Phe His Pro Ser Ala Ser Thr Ala Gly Thr Ser 
    450                 455                 460                 


Gly Asp Ser Gly Pro Pro Asp Arg Ser Pro Leu Glu Leu His Ile Gly 
465                 470                 475                 480 


Phe Pro Thr Asp Ile Pro Lys Ser Ala Pro His Ser Met Thr Ala Ser 
                485                 490                 495     


Ser Ser Ser Val Ser Ser Pro Ser Pro Gly Leu Pro Arg Arg Ser Ala 
            500                 505                 510         


Pro Pro Ser Pro Leu Cys Arg Ser Leu Ser Pro Gly Thr Gly Gly Gly 
        515                 520                 525             


Val Arg Gly Gly Val Gly Tyr Leu Ser Arg Gly Asp Pro Val Arg Val 
    530                 535                 540                 


Leu Ala Arg Arg Val Arg Pro Asp Gly Ser Val Gln Tyr Leu Val Glu 
545                 550                 555                 560 


Trp Gly Gly Gly Gly Ile Phe 
                565         


<210>  57
<211>  823
<212>  DNA
<213>  Homosapiens

<400>  57
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggcctctct gctcctgtct tttgtttgga tgccggcgct    240

gctgcctgtg gcctcccgcc ttttgttgct accccgagtc ttgctgacca tggcctctgg    300

aagccctccg acccagccct cgccggcctc ggattccggc tctggctacg ttccgggctc    360

ggtctctgca gcctttgtta cttgccccaa cgagaaggtc gccaaggaga tcgccagggc    420

cgtggtggag aagcgcctag cagcctgcgt caacctcatc cctcagatta catccatcta    480

tgagtggaaa gggaagatcg aggaagacag tgaggtgctg atgatgatta aaacccaaag    540

ttccttggtc ccagctttga cagattttgt tcgttctgtg cacccttacg aagtggccga    600

ggtaattgca ttgcctgtgg aacaggggaa ctttccgtac ctgcagtggg tgcgccaggt    660

cacagagtca gtttctgact ctatcacagt cctgccatga tgagccctgt tcctgctcat    720

catgaagatc cccgcgatac ttcaacgcct tctgacttcc aggtgatgac tgggccccca    780

ataaatcccg tctttgggtc tctctgccaa aaaaaaaaaa aaa                      823


<210>  58
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  58

Met Ile Gly Ser Gly Leu Ala Gly Ser Gly Gly Ala Gly Gly Pro Ser 
1               5                   10                  15      


Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala Ala Thr 
            20                  25                  30          


Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro 
        35                  40                  45              


Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala 
    50                  55                  60                  


Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser 
65                  70                  75                  80  


Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
                85                  90                  95      


Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
            100                 105                 110         


Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
        115                 120                 125             


Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
    130                 135                 140                 


Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
                165                 170                 175     


Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp 
            180                 185                 190         


Ser Ile Thr Val Leu Pro 
        195             


<210>  59
<211>  1072
<212>  DNA
<213>  Homosapiens

<400>  59
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gggcattctt cgggggtgca tcagagggag    360

ggcagagcct gaggatctaa gcgaaggctt ccccgggtgt aatttcctgg gctgtttgtg    420

aggagagatc gaattcgcct cctgctctca ggcctctctg ctcctgtctt ttgtttggat    480

gccggcgctg ctgcctgtgg cctcccgcct tttgttgcta ccccgagtct tgctgaccat    540

ggcctctgga agccctccga cccagccctc gccggcctcg gattccggct ctggctacgt    600

tccgggctcg gtctctgcag cctttgttac ttgccccaac gagaaggtcg ccaaggagat    660

cgccagggcc gtggtggaga agcgcctagc agcctgcgtc aacctcatcc ctcagattac    720

atccatctat gagtggaaag ggaagatcga ggaagacagt gaggtgctga tgatgattaa    780

aacccaaagt tccttggtcc cagctttgac agattttgtt cgttctgtgc acccttacga    840

agtggccgag gtaattgcat tgcctgtgga acaggggaac tttccgtacc tgcagtgggt    900

gcgccaggtc acagagtcag tttctgactc tatcacagtc ctgccatgat gagccctgtt    960

cctgctcatc atgaagatcc ccgcgatact tcaacgcctt ctgacttcca ggtgatgact   1020

gggcccccaa taaatcccgt ctttgggtct ctctgccaaa aaaaaaaaaa aa           1072


<210>  60
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  60

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  61
<211>  1041
<212>  DNA
<213>  Homosapiens

<400>  61
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gtgagtgacc ggccccgccc cgccccttcc    360

ggtcctcgaa gcctcgaccg ctacccgcac cctaaatccc agaggttggc cccctgaggt    420

gcctctctgc tcctgtcttt tgtttggatg ccggcgctgc tgcctgtggc ctcccgcctt    480

ttgttgctac cccgagtctt gctgaccatg gcctctggaa gccctccgac ccagccctcg    540

ccggcctcgg attccggctc tggctacgtt ccgggctcgg tctctgcagc ctttgttact    600

tgccccaacg agaaggtcgc caaggagatc gccagggccg tggtggagaa gcgcctagca    660

gcctgcgtca acctcatccc tcagattaca tccatctatg agtggaaagg gaagatcgag    720

gaagacagtg aggtgctgat gatgattaaa acccaaagtt ccttggtccc agctttgaca    780

gattttgttc gttctgtgca cccttacgaa gtggccgagg taattgcatt gcctgtggaa    840

caggggaact ttccgtacct gcagtgggtg cgccaggtca cagagtcagt ttctgactct    900

atcacagtcc tgccatgatg agccctgttc ctgctcatca tgaagatccc cgcgatactt    960

caacgccttc tgacttccag gtgatgactg ggcccccaat aaatcccgtc tttgggtctc   1020

tctgccaaaa aaaaaaaaaa a                                             1041


<210>  62
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  62

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  63
<211>  951
<212>  DNA
<213>  Homosapiens

<400>  63
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gcctctctgc tcctgtcttt tgtttggatg    360

ccggcgctgc tgcctgtggc ctcccgcctt ttgttgctac cccgagtctt gctgaccatg    420

gcctctggaa gccctccgac ccagccctcg ccggcctcgg attccggctc tggctacgtt    480

ccgggctcgg tctctgcagc ctttgttact tgccccaacg agaaggtcgc caaggagatc    540

gccagggccg tggtggagaa gcgcctagca gcctgcgtca acctcatccc tcagattaca    600

tccatctatg agtggaaagg gaagatcgag gaagacagtg aggtgctgat gatgattaaa    660

acccaaagtt ccttggtccc agctttgaca gattttgttc gttctgtgca cccttacgaa    720

gtggccgagg taattgcatt gcctgtggaa caggggaact ttccgtacct gcagtgggtg    780

cgccaggtca cagagtcagt ttctgactct atcacagtcc tgccatgatg agccctgttc    840

ctgctcatca tgaagatccc cgcgatactt caacgccttc tgacttccag gtgatgactg    900

ggcccccaat aaatcccgtc tttgggtctc tctgccaaaa aaaaaaaaaa a             951


<210>  64
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  64

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  65
<211>  1214
<212>  DNA
<213>  Homosapiens

<400>  65
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gtgagtgacc ggccccgccc cgccccttcc    360

ggtcctcgaa gcctcgaccg ctacccgcac cctaaatccc agaggttggc cccctgaggt    420

gtgagtgaaa tgagcttttg ctttattttc caagtttctc tctcaccttc aggggcattc    480

ttcgggggtg catcagaggg agggcagagc ctgaggatct aagcgaaggc ttccccgggt    540

gtaatttcct gggctgtttg tgaggagaga tcgaattcgc ctcctgctct caggcctctc    600

tgctcctgtc ttttgtttgg atgccggcgc tgctgcctgt ggcctcccgc cttttgttgc    660

taccccgagt cttgctgacc atggcctctg gaagccctcc gacccagccc tcgccggcct    720

cggattccgg ctctggctac gttccgggct cggtctctgc agcctttgtt acttgcccca    780

acgagaaggt cgccaaggag atcgccaggg ccgtggtgga gaagcgccta gcagcctgcg    840

tcaacctcat ccctcagatt acatccatct atgagtggaa agggaagatc gaggaagaca    900

gtgaggtgct gatgatgatt aaaacccaaa gttccttggt cccagctttg acagattttg    960

ttcgttctgt gcacccttac gaagtggccg aggtaattgc attgcctgtg gaacagggga   1020

actttccgta cctgcagtgg gtgcgccagg tcacagagtc agtttctgac tctatcacag   1080

tcctgccatg atgagccctg ttcctgctca tcatgaagat ccccgcgata cttcaacgcc   1140

ttctgacttc caggtgatga ctgggccccc aataaatccc gtctttgggt ctctctgcca   1200

aaaaaaaaaa aaaa                                                     1214


<210>  66
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  66

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  67
<211>  2730
<212>  DNA
<213>  Homosapiens

<400>  67
ttccggtctg ggacggagct gtagcggcac tgtaactgcg agggcagcgc cgcgtgtgta     60

acggcggggg cgtgtcggcg ggaaggacaa tcgggccggg actcgcggtg tccgggtgac    120

cgcggcttcc cgggagcaga cctctgtggg cactgtgagg cggaacggag cggcggggca    180

ggagctgttc tgggcagcct tcatcccgcg tggagtctac ccccaagccc ttctcctctt    240

cccaattctt gtcaccttcg aggaggccat ggaaacccca acacctttgc cgcctgtacc    300

cgcctccccg acctgcaacc cagccccacg gacaatccag atcgagttcc cacagcatag    360

ctcgtctctg ctggaatctc tgaaccgcca caggctagag ggaaagttct gtgatgtgtc    420

cctcctggtg cagggccggg aacttagggc tcataaagca gtgttagctg ctgcctctcc    480

ttacttccat gacaagctgc ttctggggga tgcgcctcgt ctcactctac cgagtgtcat    540

tgaagccgat gccttcgagg ggctgctcca gctcatttat tcagggcgtc tccgcctgcc    600

actggatgct cttcctgctc atctccttgt ggccagtggc cttcaaatgt ggcaggtagt    660

agatcagtgc tcagaaattc ttagagaatt agaaacttca ggtggtggaa tttcagcccg    720

tggaggaaac tcctaccatg cccttctttc cactacatcc tctacaggag gctggtgcat    780

tcgctcttcg cctttccaga ccccagtaca gtcctctgct tctactgaaa gccctgcttc    840

cactgagagc cctgtgggag gggagggaag tgaactggga gaagtgctgc aaattcaggt    900

ggaagaagaa gaggaggagg aggaagatga tgatgatgag gaccaggggt cagccacact    960

ctctcagact cctcagcccc agagagtatc aggggttttt ccccgtcctc atggacccca   1020

cccactgccc atgactgcta ctccccgaaa gcttccagag ggtgagagtg caccacttga   1080

gcttcctgcc cctcctgcac tgccccccaa aatcttctac attaagcagg aacccttcga   1140

gcctaaggag gagatatcag gaagcggaac tcagcctgga ggagcaaagg aggaaaccaa   1200

agtgttttct ggaggggaca ctgaagggaa tggggagcta gggttcttgt tgccttcagg   1260

gccagggcca acatctgggg gagggggtcc atcctggaaa ccagtggatc ttcatgggaa   1320

tgaaatcctg tcagggggtg gaggacctgg gggagcaggc caggccgtgc atgggcctgt   1380

gaagctaggg gggacacccc ctgcagatgg aaaacgcttt ggttgcctgt gtgggaagcg   1440

gtttgcagtg aagccaaagc gtgaccggca catcatgctg accttcagcc ttcggccttt   1500

tggctgtggc atctgcaaca agcgcttcaa gctgaagcac catctgacag agcacatgaa   1560

gacccatgct ggagccctgc atgcctgtcc ccactgtggc cgtcggttcc gagtccatgc   1620

ctgttttctc cgccaccggg acctatgcaa gggccagggc tgggccactg cccactggac   1680

ttacaagtga ctgctgaggc tatacactag cttctagaac aagataacca ctgctgctga   1740

tggatacttt tccctcactg ccatggcaca ccagtcatgg atcttgtaat catgccaaga   1800

gaatagatac attatggacc tcttgttctt agatatgggc ctctcagcct ggcagatgtg   1860

gaaactcaaa tttctcgtcc cactccaggt tttggctagc caaccctgca ggaaagtggt   1920

ttataggcca ttcatactta agttgatcac ttgcccatgg tggacatttt tgtggtggtg   1980

atgtccatta aggaaaccag attttcaatt atttagtgag agaagagtta gagcaaaaga   2040

cagtggtaaa tgttttattc cgtctccatg aggaattgaa ggagttggtc tccacctaga   2100

gatacatttg atttacagct taagtaattc agaggctaag ctctaagctt ttttctctca   2160

ttgctggaat gatttaagca gaagtccttt tgtgtacttt taaaattgta tctttccagg   2220

agcccctcag attgtacctt gctttctcac caatagacac cttcccgaca cttttttaat   2280

gttgtagctg agcactttaa caagttgagc attccatgtt tcattcttag aaccttcttt   2340

aatagagggt cttccctcaa cagcctgtgc ctctggtcta cctttgacca ccactgataa   2400

ctaatatatt ggtcacaatg actggaatgt gactagtgat ctcaggagat ggcactgtcc   2460

taaagtgctg tcagggtggc accactgctc tctgaacaac ttaccttggt cagagggact   2520

caggtttggg acagcacaag ctgaaggctg gagagtaact tgcatagtag gaccatacct   2580

cttcctttcc catcccaccc acatatgata gacagcccct ctgttgagat atggagggga   2640

cagatactgg aatcgggggt gggacttgca gttacttaaa attttttaat aaactgtgcc   2700

ctgaaaccta aaaaaaaaaa aaaaaaaaaa                                    2730


<210>  68
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  68

Met Glu Thr Pro Thr Pro Leu Pro Pro Val Pro Ala Ser Pro Thr Cys 
1               5                   10                  15      


Asn Pro Ala Pro Arg Thr Ile Gln Ile Glu Phe Pro Gln His Ser Ser 
            20                  25                  30          


Ser Leu Leu Glu Ser Leu Asn Arg His Arg Leu Glu Gly Lys Phe Cys 
        35                  40                  45              


Asp Val Ser Leu Leu Val Gln Gly Arg Glu Leu Arg Ala His Lys Ala 
    50                  55                  60                  


Val Leu Ala Ala Ala Ser Pro Tyr Phe His Asp Lys Leu Leu Leu Gly 
65                  70                  75                  80  


Asp Ala Pro Arg Leu Thr Leu Pro Ser Val Ile Glu Ala Asp Ala Phe 
                85                  90                  95      


Glu Gly Leu Leu Gln Leu Ile Tyr Ser Gly Arg Leu Arg Leu Pro Leu 
            100                 105                 110         


Asp Ala Leu Pro Ala His Leu Leu Val Ala Ser Gly Leu Gln Met Trp 
        115                 120                 125             


Gln Val Val Asp Gln Cys Ser Glu Ile Leu Arg Glu Leu Glu Thr Ser 
    130                 135                 140                 


Gly Gly Gly Ile Ser Ala Arg Gly Gly Asn Ser Tyr His Ala Leu Leu 
145                 150                 155                 160 


Ser Thr Thr Ser Ser Thr Gly Gly Trp Cys Ile Arg Ser Ser Pro Phe 
                165                 170                 175     


Gln Thr Pro Val Gln Ser Ser Ala Ser Thr Glu Ser Pro Ala Ser Thr 
            180                 185                 190         


Glu Ser Pro Val Gly Gly Glu Gly Ser Glu Leu Gly Glu Val Leu Gln 
        195                 200                 205             


Ile Gln Val Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Glu 
    210                 215                 220                 


Asp Gln Gly Ser Ala Thr Leu Ser Gln Thr Pro Gln Pro Gln Arg Val 
225                 230                 235                 240 


Ser Gly Val Phe Pro Arg Pro His Gly Pro His Pro Leu Pro Met Thr 
                245                 250                 255     


Ala Thr Pro Arg Lys Leu Pro Glu Gly Glu Ser Ala Pro Leu Glu Leu 
            260                 265                 270         


Pro Ala Pro Pro Ala Leu Pro Pro Lys Ile Phe Tyr Ile Lys Gln Glu 
        275                 280                 285             


Pro Phe Glu Pro Lys Glu Glu Ile Ser Gly Ser Gly Thr Gln Pro Gly 
    290                 295                 300                 


Gly Ala Lys Glu Glu Thr Lys Val Phe Ser Gly Gly Asp Thr Glu Gly 
305                 310                 315                 320 


Asn Gly Glu Leu Gly Phe Leu Leu Pro Ser Gly Pro Gly Pro Thr Ser 
                325                 330                 335     


Gly Gly Gly Gly Pro Ser Trp Lys Pro Val Asp Leu His Gly Asn Glu 
            340                 345                 350         


Ile Leu Ser Gly Gly Gly Gly Pro Gly Gly Ala Gly Gln Ala Val His 
        355                 360                 365             


Gly Pro Val Lys Leu Gly Gly Thr Pro Pro Ala Asp Gly Lys Arg Phe 
    370                 375                 380                 


Gly Cys Leu Cys Gly Lys Arg Phe Ala Val Lys Pro Lys Arg Asp Arg 
385                 390                 395                 400 


His Ile Met Leu Thr Phe Ser Leu Arg Pro Phe Gly Cys Gly Ile Cys 
                405                 410                 415     


Asn Lys Arg Phe Lys Leu Lys His His Leu Thr Glu His Met Lys Thr 
            420                 425                 430         


His Ala Gly Ala Leu His Ala Cys Pro His Cys Gly Arg Arg Phe Arg 
        435                 440                 445             


Val His Ala Cys Phe Leu Arg His Arg Asp Leu Cys Lys Gly Gln Gly 
    450                 455                 460                 


Trp Ala Thr Ala His Trp Thr Tyr Lys 
465                 470             


<210>  69
<211>  2165
<212>  DNA
<213>  Homosapiens

<400>  69
cgcgggtccc tcgggctgca cagggacaag taaaggctac atccagatgc cgggaatgca     60

ctgacgccca ttcctggaaa ctgggctccc actcagcccc tgggagcagc agccgccagc    120

ccctcgggac ctccatctcc accctgctga gccacccggg ttgggccagg atcccggcag    180

gctgatcccg tcctccactg agacctgaaa aatggcttcg gggcaaggcc caggtcctcc    240

caggcaggag tgcggagagc ctgccctgcc ctctgcttct gaggagcagg tagcccagga    300

cacagaggag gttttccgca gctacgtttt ttaccgccat cagcaggaac aggaggctga    360

aggggtggct gcccctgccg acccagagat ggtcacctta cctctgcaac ctagcagcac    420

catggggcag gtgggacggc agctcgccat catcggggac gacatcaacc gacgctatga    480

ctcagagttc cagaccatgt tgcagcacct gcagcccacg gcagagaatg cctatgagta    540

cttcaccaag attgccacca gcctgtttga gagtggcatc aattggggcc gtgtggtggc    600

tcttctgggc ttcggctacc gtctggccct acacgtctac cagcatggcc tgactggctt    660

cctaggccag gtgacccgct tcgtggtcga cttcatgctg catcactgca ttgcccggtg    720

gattgcacag aggggtggct gggtggcagc cctgaacttg ggcaatggtc ccatcctgaa    780

cgtgctggtg gttctgggtg tggttctgtt gggccagttt gtggtacgaa gattcttcaa    840

atcatgactc ccaagggtgc cctttggggt cccggttcag acccctgcct ggacttaagc    900

gaagtctttg ccttctctgc tcccttgcag gggtcccccc tcaagagtac agaagcttta    960

gcaagtgtgc actccagctt cggagggccc ctgcgtgggg gccagtcagg ctgcagaggc   1020

acctcaacat tgcatggtgc tagtgggccc tctctctggg cccaggggct gtggccgtct   1080

cctccctcag ctctctggga cctccttagc cctgtctgct aggcgctggg gagactgata   1140

acttggggag gcaagagact gggagccact tctccccaga aagtgtttaa cggttttagc   1200

tttttataat acccttgtga gagcccattc ccaccattct acctgaggcc aggacgtctg   1260

gggtgtgggg attggtgggt ctatgttccc caggattcag ctattctgga agatcagcac   1320

cctaagagat gggactagga cctgagcctg gtcctggccg tccctaagca tgtgtcccag   1380

gagcaggacc tactaggaga ggggggccaa ggtcctgctc aactctaccc ctgctcccat   1440

tcctccctcc ggccatactg cctttgcagt tggactctca gggattctgg gcttggggtg   1500

tggggtgggg tggagtcgca gaccagagct gtctgaactc acgtgtcaga agcctccaag   1560

cctgcctccc aaggtcctct cagttctctc ccttcctctc tccttataga cacttgctcc   1620

caacccattc actacaggtg aaggctctca cccccatccc tgggggcctt gggtgagtgg   1680

cctgctaagg ctcctccttg cccagactac agggcttagg acttggtttg ttatttcagg   1740

gaaaaggagt agggagttca tctggagggt tctaagtggg agaaggacta tcaacaccac   1800

taggaatccc agaggtggga tcctccctca tggctctggc acagtgtaat ccaggggtgt   1860

agatggggga actgtgaata cttgaactct gttcccccac cctccatgct cctcacctgt   1920

ctaggtctcc tcagggtggg gggtgacagt gccttctcta ttgggcacag cctagggtct   1980

tgggggtcag gggggagaag ttcttgattc agccaaatgc agggagggga ggcagatgga   2040

gcccataggc caccccctat cctctgagtg tttggaaata aactgtgcaa tcccctcaaa   2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaacc   2160

tcggg                                                               2165


<210>  70
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  70

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  71
<211>  2107
<212>  DNA
<213>  Homosapiens

<400>  71
agatgcgagc gcctgcgcag gtacgcacgc tccgctggag cctggggtgg cctggcagtc     60

gtggccgaga cgtgtttgct gcacttcggt gcgcacaggc actgcggtgc caacctcttg    120

gttccgccct ccccccgcag gcgcccacgc gtgacctcgg ccgcccacag gccttcgact    180

cttcccggac tccaggtccc aggccgcccc gctccaccct gcggatgatg gagacaaagt    240

cccccacaag cccctcatat ggggcaaggg ggaaggtacc acctggggcg gggcctggct    300

ccccactgag cagaggtgct ggccaaggcg ctccccttag tgagacaagg tttcaccatg    360

ttgcccaggc ttttctcaaa ctcctgagct caagcaatcc gcccacctca gcctccgaaa    420

gtgctaggat tataggcgtg agccactgca cccagcccca ggtggcaagt ctttctgata    480

ggcactgctc caaagtgaat cacactgtgc taagcccccg caagggagtg cctttgcagc    540

ttacagctgc acactcgtca tctcaggagg tccttgcaac agtccccttt cacgggtaaa    600

gaaactgagg cctctactca acctcacaga gcaagctaat gccagactaa aacctctggc    660

ctccaaaccc catgcccttt ctttttgtaa gctacacaga ctgtcagggc aaatgtccac    720

tggataaaag catgagatga tgaatggacg gaaattaacc aaaaaggtca tcaacacatt    780

ttcaacagat ccatcaatgt gcactcaaag aagctgagac aggcctaacc tttaaaggct    840

gatgtcaagg aaggggagca gcaggatggt actcggtctg acccaggggg gtcgctcccc    900

tgagcctatg tgtgtttgga gtggacgaga atgggagaga gattagaaaa acagcagcat    960

catgtgaatt acagatgcac aggaaagctt acagcctgtc tagacaaatt cacttatgtt   1020

acagatgagg aaactgaggc tcagaaagag gaagggactt gcccaaggcc acatagcaaa   1080

ggaatagcaa agttgagaca aaaataatgg acattgtgac tctgagtcaa gtgagaaaca   1140

gagagactga tggagaagtg tgtgtgtgtg tgtgtgtgtg tgtgtgttta tgtgcatgca   1200

gtgtgcactc actcaggggg ccagggtcct gaatttagaa acactaccac caagaaggca   1260

ttatgcctac cctacccagg cagtgggggc tggagccagg gcctgggggc tggaaccagg   1320

gcccagggcc tggaggggat ggtaagcctc cagccccacc ttctccagga aggggttggt   1380

ggtctggcac gggccaagcg tacctggcca tccacaatgc tcacctccac cacggtgatc   1440

tctggccggg taagcagctc tcggccctct tggctgccta gcttccagag gcgggactct   1500

tgctgcattc ccagaagctt cttcaactcc gactccagga aacctgagag ccagagagat   1560

ggcaagggac agggagatgg cagggaacag gcaggagtag gatggagcag cccactggga   1620

acccaaggac ccggaggtgc aaccgctccc tgagcctcat cccagctctg tgtggttcct   1680

gctcaccctc agccacagcc ctctcttctt ccaggacgta gagccagcca ggtaccaccc   1740

ctccttcgcc ctgccttccc caggaagctc actctttgag ggccttctct ggcagcggca   1800

gcatgagagc ctgcgtcttc acccactggg gacagcatgc aaggggcagg tatttgcccc   1860

caccaccaac caactcaaga gcctggatct ggaacccaaa ctgcctgcac tcaagtccca   1920

gctctgccca tcactagctg tgtgacatcg ggcaagttct cactgtgaac tggagatggc   1980

aataggacct acctcagagt cgtaaaatgc aggattttat gaaaagtgct taaagagggt   2040

ctgccccatt aatggctatg taaatgtgaa ccacgatttt catcatatta tgtatgctat   2100

caccact                                                             2107


<210>  72
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  72

Met Arg Ala Pro Ala Gln Val Arg Thr Leu Arg Trp Ser Leu Gly Trp 
1               5                   10                  15      


Pro Gly Ser Arg Gly Arg Asp Val Phe Ala Ala Leu Arg Cys Ala Gln 
            20                  25                  30          


Ala Leu Arg Cys Gln Pro Leu Gly Ser Ala Leu Pro Pro Gln Ala Pro 
        35                  40                  45              


Thr Arg Asp Leu Gly Arg Pro Gln Ala Phe Asp Ser Ser Arg Thr Pro 
    50                  55                  60                  


Gly Pro Arg Pro Pro Arg Ser Thr Leu Arg Met Met Glu Thr Lys Ser 
65                  70                  75                  80  


Pro Thr Ser Pro Ser Tyr Gly Ala Arg Gly Lys Val Pro Pro Gly Ala 
                85                  90                  95      


Gly Pro Gly Ser Pro Leu Ser Arg Gly Ala Gly Gln Gly Ala Pro Leu 
            100                 105                 110         


Ser Glu Thr Arg Phe His His Val Ala Gln Ala Phe Leu Lys Leu Leu 
        115                 120                 125             


Ser Ser Ser Asn Pro Pro Thr Ser Ala Ser Glu Ser Ala Arg Ile Ile 
    130                 135                 140                 


Gly Val Ser His Cys Thr Gln Pro Gln Val Ala Ser Leu Ser Asp Arg 
145                 150                 155                 160 


His Cys Ser Lys Val Asn His Thr Val Leu Ser Pro Arg Lys Gly Val 
                165                 170                 175     


Pro Leu Gln Leu Thr Ala Ala His Ser Ser Ser Gln Glu Val Leu Ala 
            180                 185                 190         


Thr Val Pro Phe His Gly 
        195             


<210>  73
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  73
cgccccccac gccctgggcc ccggagggcc gcagccatga gtgaaatgtc cagctttctt     60

cacatcgggg acatcgtctc cctgtacgcc gagggctccg tcaatggctt catcagcact    120

ttggggctgg tggatgaccg ctgtgtggtg gagcccgcgg ccggggacct ggacaacccc    180

cctaagaagt tccgtgactg cctcttcaag gtgtgcccca tgaaccgcta ctcggcccag    240

aagcagtact ggaaggccaa gcagactaag caggacaagg agaagatcgc tgatgtggtg    300

ttgctgcaga agctgcagca tgcggcgcag atggagcaga agcaaaatga cacggagaac    360

aagaaggtgc atggggatgt cgtgaagtat ggcagtgtga tccagctcct gcacatgaag    420

agcaacaagt acctgacagt gaacaagcgg cttccggcct tgctggagaa gaacgccatg    480

cgggtgactc tggatgccac aggcaacgag ggttcctggc tcttcatcca gcccttctgg    540

aagctgcgga gcaacgggga caacgtggtc gtgggggaca aggtgatcct gaatcctgtc    600

aatgccgggc agcctctgca tgccagcaat tacgagctca gcgacaacgc cggctgcaag    660

gaggtcaatt ctgtgaactg caacaccagc tggaagatca acctgtttat gcagtttcgg    720

gaccacctgg aggaggtgtt gaaaggggga gacgtggtgc ggctgttcca tgcggagcag    780

gagaagttcc tgacgtgtga cgagtacaag ggcaagctgc aggtgttcct gcgaactaca    840

ctgcgccagt ctgccacctc ggccaccagc tccaatgctc tctgggaggt ggaggtggtc    900

caccacgacc cctgccgtgg aggagctggg cactggaatg gcttgtaccg cttcaagcac    960

ctggctacag gcaactacct ggctgctgag gagaacccca gttacaaagg tgatgcctca   1020

gatcccaagg cagcaggaat gggggcacag ggccgcacag gccgcaggaa tgctggggag   1080

aagatcaagt actgcctggt ggctgtgcct catggcaatg acatcgcctc tctctttgag   1140

ctggacccca ccaccttgca gaaaaccgac tctttcgtgc cccggaactc gtacgtccgg   1200

ctgcggcacc tctgcaccaa cacgtggatt cagagcacca atgtgcccat tgacatcgag   1260

gaggagcggc ccatccggct catgctgggc acctgcccca ccaaggagga caaggaggcc   1320

tttgccatcg tgtcagtgcc cgtgtctgag atccgagacc tggactttgc caatgacgcc   1380

agctccatgc tggccagtgc cgtggagaaa ctcaacgagg gcttcatcag ccagaatgac   1440

cgcaggtttg tcatccagct gctggaagac ctggtgttct ttgtcagcga tgtccccaac   1500

aatgggcaga atgtcctgga catcatggtc actaagccca accgggaacg gcagaagctg   1560

atgagggagc agaacatcct caaacaggtc tttggcattc tgaaggtccc gttccgtgag   1620

aaggggggtg aaggtcccct ggtgcggctg gaggagctgt cagaccagaa gaacgccccc   1680

taccagcaca tgttccgcct gtgctaccgt gtgttgcggt attcccagga ggactaccgc   1740

aagaaccagg agcacattgc caagcagttt gggatgatgc agtcccagat tggctacgac   1800

atcctggccg aggacaccat cactgccctg ctgcacaaca accgcaagct cctggaaaag   1860

cacatcacca agaccgaggt ggagaccttc gtcagccttg tgcgcaagaa ccgggagccc   1920

aggttcctgg actacctctc tgacctgtgt gtgtccaacc acatcgccat ccccgtcacc   1980

caagagctca tctgcaagtg tgtgctggac cccaagaaca gtgacattct catccggacc   2040

gagcttcggc ccgtgaagga gatggcccaa tcccacgagt acctgagcat cgagtactca   2100

gaagaggaag tgtggctcac gtggactgac aagaataacg agcatcatga gaagagtgtg   2160

aggcagctgg cccaggaggc gcgggccggc aacgcccacg acgagaatgt gctcagctac   2220

tacaggtacc agctgaagct ctttgcccgc atgtgcttgg accgccagta cttggccatc   2280

gacgagatct cccagcagct gggcgtggac ctgattttcc tgtgcatggc agacgagatg   2340

ctgccctttg acctgcgcgc ctccttctgc cacctgatgc tgcacgtgca cgtggaccgt   2400

gacccccagg agctggtcac gccggtcaag tttgcccgtc tctggactga gatccccaca   2460

gccatcacca tcaaggacta tgattccaac ctcaacgcgt cccgagatga caagaagaac   2520

aagtttgcca acaccatgga gttcgtggag gactacctca acaatgtagt cagcgaggcc   2580

gtgccctttg ccaacgagga gaagaacaag ctcacttttg aggtggtcag cctggcgcac   2640

aatctcatct acttcggctt ctacagcttc agcgagctgc tgcggctcac tcgcacactg   2700

ctgggcatca tcgactgtgt gcaggggccc ccggccatgc tgcaggccta tgaggacccc   2760

ggtggcaaga atgtgcggcg gtccatccag ggcgtggggc acatgatgtc caccatggtg   2820

ctgagccgca agcagtccgt cttcagtgcc cccagcctgt ctgctggggc cagtgctgct   2880

gagccgctgg acagaagcaa gtttgaggag aatgaggaca ttgtggtgat ggagaccaag   2940

ctgaagatcc tggaaatcct tcagttcatc ctcaacgtcc gcctggatta ccgcatatcc   3000

tacctgctgt ctgtcttcaa gaaggagttt gtggaggtgt ttcccatgca ggacagtggg   3060

gctgatggca cagcccctgc cttcgactct accactgcca acatgaacct ggatcgcatc   3120

ggggagcagg cggaggccat gtttggagtg gggaagacaa gcagcatgct ggaggtggat   3180

gacgagggcg gccgcatgtt cctgcgcgtg ctcatccacc tcaccatgca cgactatgcg   3240

ccactggtct cgggtgccct gcagctgctc ttcaagcact tcagccagcg ccaggaggcc   3300

atgcacacct tcaagcaggt tcagctgctg atctcagcgc aggacgtgga gaactacaag   3360

gtgatcaagt cggagctgga ccggctgcgg accatggtgg agaagtcaga gctgtgggtg   3420

gacaagaagg gcagtggcaa gggtgaggag gtggaggcag gcaccgccaa ggacaagaaa   3480

gagcgtccca cggacgagga gggctttctg cacccaccag gggagaaaag cagtgagaac   3540

taccagatcg tcaagggcat cctggaaagg ctgaacaaga tgtgcggggt tggggagcaa   3600

atgaggaaga agcagcaacg gctgctgaag aacatggatg cccacaaggt catgctggac   3660

ctgctgcaga tcccctatga caagggtgat gccaagatga tggagatcct gcgctacacg   3720

caccagttcc tgcagaagtt ctgtgcaggg aaccccggca accaggccct gctgcacaaa   3780

cacctgcacc tcttcctcac gccagggctc ctggaggcag agaccatgca gcacatcttc   3840

ctgaacaact atcagctctg ctccgagatc agcgagcctg tgttgcagca cttcgtgcac   3900

ctgctggcca cgcacgggcg ccatgtgcag tacctggact tcctgcacac cgtcattaag   3960

gccgagggca agtacgtcaa gaagtgccag gacatgatca tgactgagct gaccaatgca   4020

ggtgacgatg tggtcgtgtt ctacaatgat aaggcatcgc tggcccacct gctggacatg   4080

atgaaggccg cccgcgacgg cgtggaggac cacagccccc tcatgtacca catttccctg   4140

gtggacctgc tggccgcctg tgccgagggc aaaaacgtct acactgagat caagtgcacc   4200

tccctcgtgc cgctggagga cgtggtgtct gtggtgacgc atgaggactg catcactgag   4260

gtgaaaatgg cctatgtgaa cttcgtgaac cactgctacg tggacacgga ggtggagatg   4320

aaggagatct acaccagcaa ccacatctgg acgctctttg agaacttcac cctggacatg   4380

gctcgggtct gcagcaagcg tgagaagcgc gtggctgacc ccaccttgga gaagtacgtg   4440

ctgagcgttg tgctggacac catcaacgcc ttcttcagct ccccattctc tgagaacagc   4500

acttccctgc agacacacca gccggttgtg gtgcagctgc tgcagtctac cacacgcctc   4560

ctcgagtgtc cgtggctaca gcagcagcac aagggctccg tggaggcctg catccggacc   4620

ctcgccatgg tggccaaggg ccgggccatc ttgctgccca tggacctgga tgcccacatc   4680

agctcgatgc tcagcagtgg agccagctgt gcagctgccg cccagcggaa cgcctccagc   4740

tacaaggcaa ccacgcgggc cttcccccgc gtcaccccca ccgccaacca gtgggactac   4800

aagaacatca ttgagaagct gcaggacatc atcacagccc tggaggagcg gctgaagccc   4860

ctggtacagg ctgagctgtc cgtgctggtg gatgtcctgc actggcctga gctgctcttc   4920

ctggagggca gtgaggccta ccagcgctgc gagagtgggg gcttcctgtc caagctgatc   4980

cagcacacca aggacctcat ggagtcggag gagaagctgt gcatcaaggt gctgcggacc   5040

ctgcagcaga tgctcgtcaa gaagaccaag tacggggacc ggggcaacca gctgcgcaag   5100

atgctgctgc aaaactacct ccagaaccgg aagtccacct cgcgggggga ccttcccgac   5160

cccataggca ctggcctgga cccagactgg tcggcaatcg cagccaccca gtgccggctg   5220

gacaaggagg gggccaccaa gttggtatgc gacctcatca ccagcaccaa gaacgagaag   5280

atcttccagg agagcatcgg cctggccatc cacctgctgg atggtggcaa cacagagatc   5340

cagaaatcct tccacaacct gatgatgagt gacaagaagt cagagcgctt cttcaaggtg   5400

ctgcacgacc gcatgaagcg ggcccagcag gagaccaagt ccacggtggc agtcaacatg   5460

aatgacctgg gcagccagcc acatgaggac cgcgagccag tcgaccccac caccaaaggc   5520

cgcgtggcct ccttctcgat acctggctcc tcatcccgct actcgctggg ccccagcctg   5580

cgccgggggc acgaggtgag cgaacgtgtg cagagcagtg agatgggcac atccgtgctc   5640

atcatgcagc ccatcctgcg ctttctgcag ctgctgtgtg agaaccacaa ccgggacctg   5700

cagaacttcc tgcgctgtca gaacaacaaa accaactaca acttggtatg cgagacgctg   5760

cagttcctgg acatcatgtg cggcagcacc acgggcggcc tggggctgct ggggctctac   5820

atcaatgagg acaacgtggg cctcgtcatc cagaccttgg agaccctcac tgagtactgc   5880

cagggcccct gccatgagaa ccagacttgc attgtgactc acgagtccaa tggcatagac   5940

atcatcaccg cactgatcct caatgacatc agccccctgt gcaagtaccg catggatctg   6000

gtgctgcagc tcaaggacaa tgcctccaag ctgctcctgg ctctgatgga gagccggcat   6060

gacagtgaaa atgctgagcg aatcctcatc agcctgcggc cccaggagct ggtggacgtc   6120

atcaagaagg cctacctgca ggaggaagag cgtgagaact cggaggtgag cccacgtgaa   6180

gtgggccata acatctatat cctggcgctg cagctctcca ggcacaataa acagctgcag   6240

cacctgctga agccggtgaa gcgcattcaa gaggaggagg ccgagggtat ctcttccatg   6300

ctcagcctca acaacaagca gctgtcacag atgctcaagt cctcagcgcc agcacaggag   6360

gaggaggaag accccctggc ctactatgag aaccacacgt cccagatcga gattgtgcgg   6420

caggaccgca gcatggagca gatcgtgttc ccagtgcccg gcatctgcca gttcctgacg   6480

gaggaaacca agcaccggct cttcaccact actgagcagg acgagcaggg cagcaaagtg   6540

agcgacttct tcgaccagtc ctccttcctg cacaacgaga tggagtggca gcgcaacgtc   6600

cgcagcatgc cgctgatcta ctggttctcc cgccgcatga ccctgtgggg cagcatctcc   6660

ttcaacctgg ccgtgtttat caacatcatc attgccttct tctaccctta catggagggc   6720

gcgtccacag gcgtgctgga ctcccctctc atctcattgc tcttctggat cctcatctgc   6780

ttctccatcg cggccctgtt caccaagcgc tacagcatcc gccccctcat cgtggcgctc   6840

atcctgcgct ccatctacta tctgggcatc gggcccacac tcaacatcct gggtgccctc   6900

aatctgacca acaagatcgt gtttgtggtg agcttcgtgg gcaaccgtgg caccttcatc   6960

cggggctata aggccatggt catggacatg gaattcctct accacgtggg ctacatcctg   7020

accagtgtcc tgggcctctt tgctcatgag ctgttctaca gcatcctgct ctttgacctc   7080

atctaccgcg aggagacgct gttcaacgtc atcaagagtg tgacccgcaa tggccgctcc   7140

atcctgctga cagccctgct ggccctcatc ctggtctacc tcttctccat cgtcggcttc   7200

ctcttcctca aggatgactt cattctcgag gtcgaccggc tgcccaacaa ccactccaca   7260

gccagccccc tggggatgcc acatggagct gctgcatttg tggacacctg cagtggggac   7320

aagatggact gtgtctcagg gctctcggtg cctgaggtcc tggaagagga cagggagctg   7380

gacagcacag agcgggcctg tgacactctg ttgatgtgca tcgtcactgt catgaaccat   7440

gggctacgca acggtggtgg cgtgggcgac attctccgca agccctccaa agatgagtct   7500

ctcttcccag cccgagtggt ctatgacctc ctgttcttct tcatcgtcat catcattgtg   7560

ctgaacctca tctttggggt aatcatcgac accttcgctg acctgcgtag tgagaagcag   7620

aagaaggagg agattcttaa gacgacatgc ttcatctgtg gtctggagag ggacaagttt   7680

gataacaaga cagtgtcatt tgaggaacac atcaagctgg agcacaacat gtggaactac   7740

ttgtacttca ttgtgctggt ccgcgtgaag aacaagaccg actacacggg ccctgagagc   7800

tacgtggccc agatgatcaa gaacaagaac ctggactggt tcccccggat gcgggccatg   7860

tcccttgtca gcaatgaggg cgagggggag cagaatgaga ttcggattct ccaggacaag   7920

ctcaactcca ccatgaagct ggtgtcccac ctcactgccc agctcaacga gctcaaggag   7980

cagatgacgg agcagcggaa acgcaggcaa cgcctaggct ttgtggatgt ccagaactgc   8040

attagccgct gaggagagcc accgaaggcc ccaacagggg atgctcatca ctggagactg   8100

cgactgggaa gaacactgcc ccctccctcg ggttgggtgg cccagccagc tggccagcct   8160

ccactcccac tctgccagac accctgacac cc                                 8192


<210>  74
<211>  2671
<212>  PRT
<213>  Homosapiens

<400>  74

Met Ser Glu Met Ser Ser Phe Leu His Ile Gly Asp Ile Val Ser Leu 
1               5                   10                  15      


Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu Val 
            20                  25                  30          


Asp Asp Arg Cys Val Val Glu Pro Ala Ala Gly Asp Leu Asp Asn Pro 
        35                  40                  45              


Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn Arg 
    50                  55                  60                  


Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Thr Lys Gln Asp 
65                  70                  75                  80  


Lys Glu Lys Ile Ala Asp Val Val Leu Leu Gln Lys Leu Gln His Ala 
                85                  90                  95      


Ala Gln Met Glu Gln Lys Gln Asn Asp Thr Glu Asn Lys Lys Val His 
            100                 105                 110         


Gly Asp Val Val Lys Tyr Gly Ser Val Ile Gln Leu Leu His Met Lys 
        115                 120                 125             


Ser Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu 
    130                 135                 140                 


Lys Asn Ala Met Arg Val Thr Leu Asp Ala Thr Gly Asn Glu Gly Ser 
145                 150                 155                 160 


Trp Leu Phe Ile Gln Pro Phe Trp Lys Leu Arg Ser Asn Gly Asp Asn 
                165                 170                 175     


Val Val Val Gly Asp Lys Val Ile Leu Asn Pro Val Asn Ala Gly Gln 
            180                 185                 190         


Pro Leu His Ala Ser Asn Tyr Glu Leu Ser Asp Asn Ala Gly Cys Lys 
        195                 200                 205             


Glu Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Asn Leu Phe 
    210                 215                 220                 


Met Gln Phe Arg Asp His Leu Glu Glu Val Leu Lys Gly Gly Asp Val 
225                 230                 235                 240 


Val Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu 
                245                 250                 255     


Tyr Lys Gly Lys Leu Gln Val Phe Leu Arg Thr Thr Leu Arg Gln Ser 
            260                 265                 270         


Ala Thr Ser Ala Thr Ser Ser Asn Ala Leu Trp Glu Val Glu Val Val 
        275                 280                 285             


His His Asp Pro Cys Arg Gly Gly Ala Gly His Trp Asn Gly Leu Tyr 
    290                 295                 300                 


Arg Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Glu Asn 
305                 310                 315                 320 


Pro Ser Tyr Lys Gly Asp Ala Ser Asp Pro Lys Ala Ala Gly Met Gly 
                325                 330                 335     


Ala Gln Gly Arg Thr Gly Arg Arg Asn Ala Gly Glu Lys Ile Lys Tyr 
            340                 345                 350         


Cys Leu Val Ala Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                 360                 365             


Leu Asp Pro Thr Thr Leu Gln Lys Thr Asp Ser Phe Val Pro Arg Asn 
    370                 375                 380                 


Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Ile Gln Ser 
385                 390                 395                 400 


Thr Asn Val Pro Ile Asp Ile Glu Glu Glu Arg Pro Ile Arg Leu Met 
                405                 410                 415     


Leu Gly Thr Cys Pro Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                 425                 430         


Ser Val Pro Val Ser Glu Ile Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                 440                 445             


Ser Ser Met Leu Ala Ser Ala Val Glu Lys Leu Asn Glu Gly Phe Ile 
    450                 455                 460                 


Ser Gln Asn Asp Arg Arg Phe Val Ile Gln Leu Leu Glu Asp Leu Val 
465                 470                 475                 480 


Phe Phe Val Ser Asp Val Pro Asn Asn Gly Gln Asn Val Leu Asp Ile 
                485                 490                 495     


Met Val Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                 505                 510         


Asn Ile Leu Lys Gln Val Phe Gly Ile Leu Lys Val Pro Phe Arg Glu 
        515                 520                 525             


Lys Gly Gly Glu Gly Pro Leu Val Arg Leu Glu Glu Leu Ser Asp Gln 
    530                 535                 540                 


Lys Asn Ala Pro Tyr Gln His Met Phe Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg Tyr Ser Gln Glu Asp Tyr Arg Lys Asn Gln Glu His Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Met Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Lys Thr Glu Val Glu Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Asn His Ile Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Cys Val 
                645                 650                 655     


Leu Asp Pro Lys Asn Ser Asp Ile Leu Ile Arg Thr Glu Leu Arg Pro 
            660                 665                 670         


Val Lys Glu Met Ala Gln Ser His Glu Tyr Leu Ser Ile Glu Tyr Ser 
        675                 680                 685             


Glu Glu Glu Val Trp Leu Thr Trp Thr Asp Lys Asn Asn Glu His His 
    690                 695                 700                 


Glu Lys Ser Val Arg Gln Leu Ala Gln Glu Ala Arg Ala Gly Asn Ala 
705                 710                 715                 720 


His Asp Glu Asn Val Leu Ser Tyr Tyr Arg Tyr Gln Leu Lys Leu Phe 
                725                 730                 735     


Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asp Glu Ile Ser 
            740                 745                 750         


Gln Gln Leu Gly Val Asp Leu Ile Phe Leu Cys Met Ala Asp Glu Met 
        755                 760                 765             


Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys His Leu Met Leu His Val 
    770                 775                 780                 


His Val Asp Arg Asp Pro Gln Glu Leu Val Thr Pro Val Lys Phe Ala 
785                 790                 795                 800 


Arg Leu Trp Thr Glu Ile Pro Thr Ala Ile Thr Ile Lys Asp Tyr Asp 
                805                 810                 815     


Ser Asn Leu Asn Ala Ser Arg Asp Asp Lys Lys Asn Lys Phe Ala Asn 
            820                 825                 830         


Thr Met Glu Phe Val Glu Asp Tyr Leu Asn Asn Val Val Ser Glu Ala 
        835                 840                 845             


Val Pro Phe Ala Asn Glu Glu Lys Asn Lys Leu Thr Phe Glu Val Val 
    850                 855                 860                 


Ser Leu Ala His Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser Glu 
865                 870                 875                 880 


Leu Leu Arg Leu Thr Arg Thr Leu Leu Gly Ile Ile Asp Cys Val Gln 
                885                 890                 895     


Gly Pro Pro Ala Met Leu Gln Ala Tyr Glu Asp Pro Gly Gly Lys Asn 
            900                 905                 910         


Val Arg Arg Ser Ile Gln Gly Val Gly His Met Met Ser Thr Met Val 
        915                 920                 925             


Leu Ser Arg Lys Gln Ser Val Phe Ser Ala Pro Ser Leu Ser Ala Gly 
    930                 935                 940                 


Ala Ser Ala Ala Glu Pro Leu Asp Arg Ser Lys Phe Glu Glu Asn Glu 
945                 950                 955                 960 


Asp Ile Val Val Met Glu Thr Lys Leu Lys Ile Leu Glu Ile Leu Gln 
                965                 970                 975     


Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Tyr Leu Leu Ser 
            980                 985                 990         


Val Phe Lys Lys Glu Phe Val Glu  Val Phe Pro Met Gln  Asp Ser Gly 
        995                 1000                 1005             


Ala Asp  Gly Thr Ala Pro Ala  Phe Asp Ser Thr Thr  Ala Asn Met 
    1010                 1015                 1020             


Asn Leu  Asp Arg Ile Gly Glu  Gln Ala Glu Ala Met  Phe Gly Val 
    1025                 1030                 1035             


Gly Lys  Thr Ser Ser Met Leu  Glu Val Asp Asp Glu  Gly Gly Arg 
    1040                 1045                 1050             


Met Phe  Leu Arg Val Leu Ile  His Leu Thr Met His  Asp Tyr Ala 
    1055                 1060                 1065             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Lys  His Phe Ser 
    1070                 1075                 1080             


Gln Arg  Gln Glu Ala Met His  Thr Phe Lys Gln Val  Gln Leu Leu 
    1085                 1090                 1095             


Ile Ser  Ala Gln Asp Val Glu  Asn Tyr Lys Val Ile  Lys Ser Glu 
    1100                 1105                 1110             


Leu Asp  Arg Leu Arg Thr Met  Val Glu Lys Ser Glu  Leu Trp Val 
    1115                 1120                 1125             


Asp Lys  Lys Gly Ser Gly Lys  Gly Glu Glu Val Glu  Ala Gly Thr 
    1130                 1135                 1140             


Ala Lys  Asp Lys Lys Glu Arg  Pro Thr Asp Glu Glu  Gly Phe Leu 
    1145                 1150                 1155             


His Pro  Pro Gly Glu Lys Ser  Ser Glu Asn Tyr Gln  Ile Val Lys 
    1160                 1165                 1170             


Gly Ile  Leu Glu Arg Leu Asn  Lys Met Cys Gly Val  Gly Glu Gln 
    1175                 1180                 1185             


Met Arg  Lys Lys Gln Gln Arg  Leu Leu Lys Asn Met  Asp Ala His 
    1190                 1195                 1200             


Lys Val  Met Leu Asp Leu Leu  Gln Ile Pro Tyr Asp  Lys Gly Asp 
    1205                 1210                 1215             


Ala Lys  Met Met Glu Ile Leu  Arg Tyr Thr His Gln  Phe Leu Gln 
    1220                 1225                 1230             


Lys Phe  Cys Ala Gly Asn Pro  Gly Asn Gln Ala Leu  Leu His Lys 
    1235                 1240                 1245             


His Leu  His Leu Phe Leu Thr  Pro Gly Leu Leu Glu  Ala Glu Thr 
    1250                 1255                 1260             


Met Gln  His Ile Phe Leu Asn  Asn Tyr Gln Leu Cys  Ser Glu Ile 
    1265                 1270                 1275             


Ser Glu  Pro Val Leu Gln His  Phe Val His Leu Leu  Ala Thr His 
    1280                 1285                 1290             


Gly Arg  His Val Gln Tyr Leu  Asp Phe Leu His Thr  Val Ile Lys 
    1295                 1300                 1305             


Ala Glu  Gly Lys Tyr Val Lys  Lys Cys Gln Asp Met  Ile Met Thr 
    1310                 1315                 1320             


Glu Leu  Thr Asn Ala Gly Asp  Asp Val Val Val Phe  Tyr Asn Asp 
    1325                 1330                 1335             


Lys Ala  Ser Leu Ala His Leu  Leu Asp Met Met Lys  Ala Ala Arg 
    1340                 1345                 1350             


Asp Gly  Val Glu Asp His Ser  Pro Leu Met Tyr His  Ile Ser Leu 
    1355                 1360                 1365             


Val Asp  Leu Leu Ala Ala Cys  Ala Glu Gly Lys Asn  Val Tyr Thr 
    1370                 1375                 1380             


Glu Ile  Lys Cys Thr Ser Leu  Val Pro Leu Glu Asp  Val Val Ser 
    1385                 1390                 1395             


Val Val  Thr His Glu Asp Cys  Ile Thr Glu Val Lys  Met Ala Tyr 
    1400                 1405                 1410             


Val Asn  Phe Val Asn His Cys  Tyr Val Asp Thr Glu  Val Glu Met 
    1415                 1420                 1425             


Lys Glu  Ile Tyr Thr Ser Asn  His Ile Trp Thr Leu  Phe Glu Asn 
    1430                 1435                 1440             


Phe Thr  Leu Asp Met Ala Arg  Val Cys Ser Lys Arg  Glu Lys Arg 
    1445                 1450                 1455             


Val Ala  Asp Pro Thr Leu Glu  Lys Tyr Val Leu Ser  Val Val Leu 
    1460                 1465                 1470             


Asp Thr  Ile Asn Ala Phe Phe  Ser Ser Pro Phe Ser  Glu Asn Ser 
    1475                 1480                 1485             


Thr Ser  Leu Gln Thr His Gln  Pro Val Val Val Gln  Leu Leu Gln 
    1490                 1495                 1500             


Ser Thr  Thr Arg Leu Leu Glu  Cys Pro Trp Leu Gln  Gln Gln His 
    1505                 1510                 1515             


Lys Gly  Ser Val Glu Ala Cys  Ile Arg Thr Leu Ala  Met Val Ala 
    1520                 1525                 1530             


Lys Gly  Arg Ala Ile Leu Leu  Pro Met Asp Leu Asp  Ala His Ile 
    1535                 1540                 1545             


Ser Ser  Met Leu Ser Ser Gly  Ala Ser Cys Ala Ala  Ala Ala Gln 
    1550                 1555                 1560             


Arg Asn  Ala Ser Ser Tyr Lys  Ala Thr Thr Arg Ala  Phe Pro Arg 
    1565                 1570                 1575             


Val Thr  Pro Thr Ala Asn Gln  Trp Asp Tyr Lys Asn  Ile Ile Glu 
    1580                 1585                 1590             


Lys Leu  Gln Asp Ile Ile Thr  Ala Leu Glu Glu Arg  Leu Lys Pro 
    1595                 1600                 1605             


Leu Val  Gln Ala Glu Leu Ser  Val Leu Val Asp Val  Leu His Trp 
    1610                 1615                 1620             


Pro Glu  Leu Leu Phe Leu Glu  Gly Ser Glu Ala Tyr  Gln Arg Cys 
    1625                 1630                 1635             


Glu Ser  Gly Gly Phe Leu Ser  Lys Leu Ile Gln His  Thr Lys Asp 
    1640                 1645                 1650             


Leu Met  Glu Ser Glu Glu Lys  Leu Cys Ile Lys Val  Leu Arg Thr 
    1655                 1660                 1665             


Leu Gln  Gln Met Leu Val Lys  Lys Thr Lys Tyr Gly  Asp Arg Gly 
    1670                 1675                 1680             


Asn Gln  Leu Arg Lys Met Leu  Leu Gln Asn Tyr Leu  Gln Asn Arg 
    1685                 1690                 1695             


Lys Ser  Thr Ser Arg Gly Asp  Leu Pro Asp Pro Ile  Gly Thr Gly 
    1700                 1705                 1710             


Leu Asp  Pro Asp Trp Ser Ala  Ile Ala Ala Thr Gln  Cys Arg Leu 
    1715                 1720                 1725             


Asp Lys  Glu Gly Ala Thr Lys  Leu Val Cys Asp Leu  Ile Thr Ser 
    1730                 1735                 1740             


Thr Lys  Asn Glu Lys Ile Phe  Gln Glu Ser Ile Gly  Leu Ala Ile 
    1745                 1750                 1755             


His Leu  Leu Asp Gly Gly Asn  Thr Glu Ile Gln Lys  Ser Phe His 
    1760                 1765                 1770             


Asn Leu  Met Met Ser Asp Lys  Lys Ser Glu Arg Phe  Phe Lys Val 
    1775                 1780                 1785             


Leu His  Asp Arg Met Lys Arg  Ala Gln Gln Glu Thr  Lys Ser Thr 
    1790                 1795                 1800             


Val Ala  Val Asn Met Asn Asp  Leu Gly Ser Gln Pro  His Glu Asp 
    1805                 1810                 1815             


Arg Glu  Pro Val Asp Pro Thr  Thr Lys Gly Arg Val  Ala Ser Phe 
    1820                 1825                 1830             


Ser Ile  Pro Gly Ser Ser Ser  Arg Tyr Ser Leu Gly  Pro Ser Leu 
    1835                 1840                 1845             


Arg Arg  Gly His Glu Val Ser  Glu Arg Val Gln Ser  Ser Glu Met 
    1850                 1855                 1860             


Gly Thr  Ser Val Leu Ile Met  Gln Pro Ile Leu Arg  Phe Leu Gln 
    1865                 1870                 1875             


Leu Leu  Cys Glu Asn His Asn  Arg Asp Leu Gln Asn  Phe Leu Arg 
    1880                 1885                 1890             


Cys Gln  Asn Asn Lys Thr Asn  Tyr Asn Leu Val Cys  Glu Thr Leu 
    1895                 1900                 1905             


Gln Phe  Leu Asp Ile Met Cys  Gly Ser Thr Thr Gly  Gly Leu Gly 
    1910                 1915                 1920             


Leu Leu  Gly Leu Tyr Ile Asn  Glu Asp Asn Val Gly  Leu Val Ile 
    1925                 1930                 1935             


Gln Thr  Leu Glu Thr Leu Thr  Glu Tyr Cys Gln Gly  Pro Cys His 
    1940                 1945                 1950             


Glu Asn  Gln Thr Cys Ile Val  Thr His Glu Ser Asn  Gly Ile Asp 
    1955                 1960                 1965             


Ile Ile  Thr Ala Leu Ile Leu  Asn Asp Ile Ser Pro  Leu Cys Lys 
    1970                 1975                 1980             


Tyr Arg  Met Asp Leu Val Leu  Gln Leu Lys Asp Asn  Ala Ser Lys 
    1985                 1990                 1995             


Leu Leu  Leu Ala Leu Met Glu  Ser Arg His Asp Ser  Glu Asn Ala 
    2000                 2005                 2010             


Glu Arg  Ile Leu Ile Ser Leu  Arg Pro Gln Glu Leu  Val Asp Val 
    2015                 2020                 2025             


Ile Lys  Lys Ala Tyr Leu Gln  Glu Glu Glu Arg Glu  Asn Ser Glu 
    2030                 2035                 2040             


Val Ser  Pro Arg Glu Val Gly  His Asn Ile Tyr Ile  Leu Ala Leu 
    2045                 2050                 2055             


Gln Leu  Ser Arg His Asn Lys  Gln Leu Gln His Leu  Leu Lys Pro 
    2060                 2065                 2070             


Val Lys  Arg Ile Gln Glu Glu  Glu Ala Glu Gly Ile  Ser Ser Met 
    2075                 2080                 2085             


Leu Ser  Leu Asn Asn Lys Gln  Leu Ser Gln Met Leu  Lys Ser Ser 
    2090                 2095                 2100             


Ala Pro  Ala Gln Glu Glu Glu  Glu Asp Pro Leu Ala  Tyr Tyr Glu 
    2105                 2110                 2115             


Asn His  Thr Ser Gln Ile Glu  Ile Val Arg Gln Asp  Arg Ser Met 
    2120                 2125                 2130             


Glu Gln  Ile Val Phe Pro Val  Pro Gly Ile Cys Gln  Phe Leu Thr 
    2135                 2140                 2145             


Glu Glu  Thr Lys His Arg Leu  Phe Thr Thr Thr Glu  Gln Asp Glu 
    2150                 2155                 2160             


Gln Gly  Ser Lys Val Ser Asp  Phe Phe Asp Gln Ser  Ser Phe Leu 
    2165                 2170                 2175             


His Asn  Glu Met Glu Trp Gln  Arg Asn Val Arg Ser  Met Pro Leu 
    2180                 2185                 2190             


Ile Tyr  Trp Phe Ser Arg Arg  Met Thr Leu Trp Gly  Ser Ile Ser 
    2195                 2200                 2205             


Phe Asn  Leu Ala Val Phe Ile  Asn Ile Ile Ile Ala  Phe Phe Tyr 
    2210                 2215                 2220             


Pro Tyr  Met Glu Gly Ala Ser  Thr Gly Val Leu Asp  Ser Pro Leu 
    2225                 2230                 2235             


Ile Ser  Leu Leu Phe Trp Ile  Leu Ile Cys Phe Ser  Ile Ala Ala 
    2240                 2245                 2250             


Leu Phe  Thr Lys Arg Tyr Ser  Ile Arg Pro Leu Ile  Val Ala Leu 
    2255                 2260                 2265             


Ile Leu  Arg Ser Ile Tyr Tyr  Leu Gly Ile Gly Pro  Thr Leu Asn 
    2270                 2275                 2280             


Ile Leu  Gly Ala Leu Asn Leu  Thr Asn Lys Ile Val  Phe Val Val 
    2285                 2290                 2295             


Ser Phe  Val Gly Asn Arg Gly  Thr Phe Ile Arg Gly  Tyr Lys Ala 
    2300                 2305                 2310             


Met Val  Met Asp Met Glu Phe  Leu Tyr His Val Gly  Tyr Ile Leu 
    2315                 2320                 2325             


Thr Ser  Val Leu Gly Leu Phe  Ala His Glu Leu Phe  Tyr Ser Ile 
    2330                 2335                 2340             


Leu Leu  Phe Asp Leu Ile Tyr  Arg Glu Glu Thr Leu  Phe Asn Val 
    2345                 2350                 2355             


Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser Ile Leu  Leu Thr Ala 
    2360                 2365                 2370             


Leu Leu  Ala Leu Ile Leu Val  Tyr Leu Phe Ser Ile  Val Gly Phe 
    2375                 2380                 2385             


Leu Phe  Leu Lys Asp Asp Phe  Ile Leu Glu Val Asp  Arg Leu Pro 
    2390                 2395                 2400             


Asn Asn  His Ser Thr Ala Ser  Pro Leu Gly Met Pro  His Gly Ala 
    2405                 2410                 2415             


Ala Ala  Phe Val Asp Thr Cys  Ser Gly Asp Lys Met  Asp Cys Val 
    2420                 2425                 2430             


Ser Gly  Leu Ser Val Pro Glu  Val Leu Glu Glu Asp  Arg Glu Leu 
    2435                 2440                 2445             


Asp Ser  Thr Glu Arg Ala Cys  Asp Thr Leu Leu Met  Cys Ile Val 
    2450                 2455                 2460             


Thr Val  Met Asn His Gly Leu  Arg Asn Gly Gly Gly  Val Gly Asp 
    2465                 2470                 2475             


Ile Leu  Arg Lys Pro Ser Lys  Asp Glu Ser Leu Phe  Pro Ala Arg 
    2480                 2485                 2490             


Val Val  Tyr Asp Leu Leu Phe  Phe Phe Ile Val Ile  Ile Ile Val 
    2495                 2500                 2505             


Leu Asn  Leu Ile Phe Gly Val  Ile Ile Asp Thr Phe  Ala Asp Leu 
    2510                 2515                 2520             


Arg Ser  Glu Lys Gln Lys Lys  Glu Glu Ile Leu Lys  Thr Thr Cys 
    2525                 2530                 2535             


Phe Ile  Cys Gly Leu Glu Arg  Asp Lys Phe Asp Asn  Lys Thr Val 
    2540                 2545                 2550             


Ser Phe  Glu Glu His Ile Lys  Leu Glu His Asn Met  Trp Asn Tyr 
    2555                 2560                 2565             


Leu Tyr  Phe Ile Val Leu Val  Arg Val Lys Asn Lys  Thr Asp Tyr 
    2570                 2575                 2580             


Thr Gly  Pro Glu Ser Tyr Val  Ala Gln Met Ile Lys  Asn Lys Asn 
    2585                 2590                 2595             


Leu Asp  Trp Phe Pro Arg Met  Arg Ala Met Ser Leu  Val Ser Asn 
    2600                 2605                 2610             


Glu Gly  Glu Gly Glu Gln Asn  Glu Ile Arg Ile Leu  Gln Asp Lys 
    2615                 2620                 2625             


Leu Asn  Ser Thr Met Lys Leu  Val Ser His Leu Thr  Ala Gln Leu 
    2630                 2635                 2640             


Asn Glu  Leu Lys Glu Gln Met  Thr Glu Gln Arg Lys  Arg Arg Gln 
    2645                 2650                 2655             


Arg Leu  Gly Phe Val Asp Val  Gln Asn Cys Ile Ser  Arg 
    2660                 2665                 2670     


<210>  75
<211>  5815
<212>  DNA
<213>  Homosapiens

<400>  75
ggccactctt cgctcgggta aacaggaaag gaaatacccc ttgtggatta aaatttaaaa     60

aaaattctgt tggggtcgaa ggagggaggt ggggtttgcc tgcgcgcgtg ttggactccg    120

gagagcaact caggagcccg cgcggtcgtc gcctcccggc ctggccatgg actggcggga    180

agagggagca gggcgcccgg gctgctcggg cccctagccg ggcgctccct cgccaccggc    240

cccgctgcgg gcctctaggg gactgagacg gtctcttgtt cgcctggacg gcgccgggga    300

gcggaggatc tgcgctccgg gtctccagga tgtgcccgtc tgagatgggg acgctgtggc    360

accactggtc gccggtactc atcagcctgg ccgccctgtt ttccaaagtg acggaaggtc    420

gagggatcct tgagagcatc cagaggtttt ccttgctgcc cacctacctc cccgtgacct    480

accacatcaa caacgcggac gtctccttct tcctgaagga ggccaaccag gatatcatga    540

ggaactccag cctgcagtcc cgggtggagt catttctgat ttacaaatcc aggaggctgc    600

ctgtcctcaa tgccagctac gggcctttct ccatcgagca agtggtgccc caggatttaa    660

tgctaccttc caacccattt ggattcacca acaaattttc tcttaactgg aaactaaaag    720

cccacatcct gcgggacaaa gtctacctga gccggcccaa agtgcaggtt ctgttccaca    780

tcatgggcag agactgggac gaccgcagcg ccggggagaa gctgccgtgc ctgagggtct    840

ttgctttccg agagacccga gaggtgcggg gcagctgccg gctgcagggg gacctggggc    900

tgtgcgtggc cgagctggag ctcctgtcca gctggttcag cccccccacg gtggttgccg    960

ggaggaggaa gtccgtggac cagccggagg ggacccccgt ggagctctac tacaccgtgc   1020

acccaggggg tgagagaggg gactgcgtca gggaagacgc gaggagaagc aatgggatcc   1080

ggacaggcca cagtgacatc gatgagtccg ggcccccctt gcagaggatc gggagcatct   1140

tcctttatca gacacacagg aaaccctccc tgagagaact gcgtctggac aacagcgtgg   1200

ccatccacta tataccaaag accgtgagga aaggagacgt gctgactttt cctgtttcca   1260

tctccagaaa ttccactgaa gatcgcttca cgttgagggc aaaggtgaag aaaggcgtga   1320

acatcatcgg cgtgcgagcc agcagccctt ccatttggga tgtcaaggag cgcacggatt   1380

atactggaaa gtatgcacca gctgtcatcg tttgtcagaa gaaagcagct ggctcagaaa   1440

acagtgcgga tggcgcctcc tacgaggtca tgcagatcga tgtggaggtg gaagagcctg   1500

gtgacctgcc agccacacag ctggtcacgt ggcaggtcga gtaccccgga gagatcacgt   1560

ctgacttggg agtgtccaag atctatgtga gcccaaagga cttgattgga gttgtgccgc   1620

tggctatgga ggcagaaatc ctgaacacag ccatcctcac ggggaagacg gtggccgtcc   1680

cggtgaaagt ggtctccgtg gaggacgacg gcacagtgac agagctgctg gagtctgtgg   1740

agtgtagatc gtctgatgaa gacgtgatta aggtttctga cagatgtgac tacgtctttg   1800

tcaatgggaa agaaatgaaa ggcaaggtca acgtggtggt gaacttcacc taccagcacc   1860

tgagcagccc cctggagatg acggtgtggg tgccccggct tccgctgcag atcgaggtct   1920

ccgacaccga gctcaatcag atcaagggtt ggagagtgcc catcgtctcc agcaggaggc   1980

ctgccgggga cagtgaagag gaggaggatg atgagcggag gggccgcggc tgcaccctgc   2040

agtaccagca cgccatggtg cgggtcctga cgcagtttgt ggctgaagcg gccggccctg   2100

ggggacacct ggcccacctg ctgggctcag actggcaagt ggacatcacg gagctgataa   2160

atgacttcat gcaggtggag gagcccagga tcgccaagct gcaaggcgga cagattctga   2220

tggggcagga gcttgggatg accaccattc agatcctgtc tcctctgtca gacaccatcc   2280

tcgctgaaaa gaccatcact gtgctggacg agaaggtgac catcacagac ctcggggtgc   2340

agctggtgac agggctgtca ctctccttgc agctcagccc aggaagcaac agggccatct   2400

ttgccactgc agtgactcag gaacttctgc agaggccaaa acaggaagca gccatcagtt   2460

gctgggtcca gttcagtgat ggctcagtca cgcccttgga tatttacgat gggaaagact   2520

tctccttgat ggccacatct ttggatgaga aggtagtctc catccaccaa gaccccaaat   2580

tcaagtggcc tatcattgct gcggaaacag aaggacaagg caccctggtc aaggtggaaa   2640

tggttattag tgaatcctgc cagaaatcca agcggaagag tgtgttagct gttggaacgg   2700

caaacatcaa agttaaattt ggccaaaacg atgctaaccc caacaccagt gacagcagac   2760

acacaggggc aggggttcac atggaaaaca atgtcagtga cagaaggccc aaaaaaccct   2820

cgcaggaatg ggggagtcag gaaggacagt actatggcag ttcttctatg ggactcatgg   2880

agggacgggg caccacgaca gacaggtcca tcctgcagaa gaagaaaggc caggaaagcc   2940

ttttagatga caacagccac ttgcagacca tccccagcga cctcaccagc ttcccagccc   3000

aggtggacct ccccagaagc aatggggaaa tggatgggaa tgaccttatg caggcatcca   3060

aagggctgag cgacttagaa attgggatgt atgctttgtt gggagtcttc tgtttggcca   3120

ttttggtctt cttgataaac tgtgtgacct ttgcattaaa atacagacac aaacaggttc   3180

ccttcgagga gcaggaaggg atgagtcact ctcatgactg ggttgggtta agcaaccgga   3240

cagagctgtt ggagaatcac atcaactttg cctcctcgca agatgagcaa atcactgcca   3300

ttgacagggg catggatttc gaggaaagta aatatctcct cagcacaaac tcccaaaaaa   3360

gcatcaatgg gcagctgttc aaacctttgg gacccatcat cattgatggg aaagatcaga   3420

aaagtgagcc cccaacatcc cctacctcaa aaaggaaaag ggtaaaattt accaccttca   3480

ccgccgtctc ctcagacgac gagtacccca ccaggaactc catcgtgatg agtagcgagg   3540

atgacattaa gtgggtctgc caggatctgg accctgggga ctgcaaagag ctgcacaact   3600

acatggagag gttacatgaa aatgtgtaag ccagacacac acagacattg gttctcactc   3660

acctttcagc ctttaattcc aggatgtgta gcaacggtgc ccccggaaga gaaacaaagc   3720

agcaggacaa aataaggatg acactatcca tacagcctca gccaatgacc ccggctcggc   3780

ggcgaggcct ggagtccgca tcgacgcaca cattccagag tacagtgtct tgcttaagag   3840

gtttatcatg catggcaaga tttttaagac ttgaaacaaa aacgagttct gaatcactga   3900

gcgtctgaga gcgtccagga aagaacagcc tctctctctc gaatcaaagc aatttggata   3960

ttgtaaaatc cacatggctc caatattcaa tattgcagac tatggaagaa aagtacaact   4020

caggtggagc atccatggat cgcatccatg gatcgcatcc atggatcaat gggaggaagc   4080

gtgtcatcga aactggagca gcacatcttg ctgtgagcgc gatcacaggc agtccagtgc   4140

cgccgtcagc tgtgggaggc atgattgtga gtcactgtct ctcaaaggct gggccagagc   4200

tgtctcagat catggacagg ccaaggaagt ggctgacaag gactgaaagg gaacatgtgg   4260

gctaacaggc cacaaatacc tttgtaacta catgccaagg acaaacacat ggacgcaaat   4320

cctctgagcc cttcagggta cttctttatt tgtaaactaa ggatactggg catagaattt   4380

gaatcaggtt caaagaacca cgctcttttg attcatatca agttcacaat gtatccattt   4440

ctattcctcc actgcattgc catcctcccc aaagccgttg gtcacctgtg ggtgggggag   4500

ggagagggca gtttgtagta tttgctgggt cttttttctc cccctgggtt ttgtgtcaac   4560

tcccaagtga cattctgtag agaagctccc cccgcaacct gggcatatgc cccacgccgt   4620

ccgtctttga agaggctggt ctctaggcat gggcggtagt cacggtgaat tccataccag   4680

gggatataca ttcccttgct ttactagaaa gaaaacaggg ccacttggga tgggtctttc   4740

actgttcatg gcagatctcc tgtccaaaga tgtggcctcg aggctgttga gacaaatcgg   4800

ggtgcctgtg tggaacgtgc agggcgtgtg gagttggggg ggttctgggt gtgaaagtgg   4860

tggatccagc aggaagccca gcctcacaca caccggacag cacagaaacc ttcttcatct   4920

tggaggtgcg aagggataag gggcatcagt gcatgtggtg aagatgcagg tttgcaagca   4980

cttggtcctg cagtcagccc cgaaaggttc agcattgctt aagaccagcc atgactctgg   5040

atatccctga atcccttcac ttatgaagcc tatgaagatg ggggcaagga tacatcagag   5100

aattcctgcc tcatctcacg ctcactccaa ggtagagaat ggtgtgttgg gtgattgcca   5160

gccagatagg atcctgcgaa agatggtcgg gggcagcggg tggtgggcag aagaggccgt   5220

gctgttgaat tgatcttcta tttttccctc tggtcatttt ctctctctct ctgctcttca   5280

gttgtctgtt ttccagtctc tctgtgtgtc tgtctctgta tctctctcct cctttgaacc   5340

tatcttctcc ctgcttcctc tccatctcat ctctgtaatt ttgagtgtgt gtctttactc   5400

cttcttcctc tccatagaat tgaattctct ttagatcatg tgtgtgtaaa tttcaccagt   5460

ttaccctccc aaccttagcc ctctcccctg caactgtggt gctcttgaga ctgaggtttc   5520

tgcagccagt aagtcacctg ctcctgtccg caagcttacc taccttgttt ggttgggtga   5580

ttaagctgtc accccttttc aatgagaatc ctttgctttc agtaacgtcc tcatatttct   5640

ttccattctt acctgtgtca tgttctgttg aatactgcag ccgctgcccg cttccaaatc   5700

catctgcgtg tagaatgtac tgtagattgt aagaatgtaa tatatattta taaacttact   5760

gactgtaaat ataaagtttg cattcagtga caaaaaaaaa aaaaaaaaaa aaaaa        5815


<210>  76
<211>  1099
<212>  PRT
<213>  Homosapiens

<400>  76

Met Cys Pro Ser Glu Met Gly Thr Leu Trp His His Trp Ser Pro Val 
1               5                   10                  15      


Leu Ile Ser Leu Ala Ala Leu Phe Ser Lys Val Thr Glu Gly Arg Gly 
            20                  25                  30          


Ile Leu Glu Ser Ile Gln Arg Phe Ser Leu Leu Pro Thr Tyr Leu Pro 
        35                  40                  45              


Val Thr Tyr His Ile Asn Asn Ala Asp Val Ser Phe Phe Leu Lys Glu 
    50                  55                  60                  


Ala Asn Gln Asp Ile Met Arg Asn Ser Ser Leu Gln Ser Arg Val Glu 
65                  70                  75                  80  


Ser Phe Leu Ile Tyr Lys Ser Arg Arg Leu Pro Val Leu Asn Ala Ser 
                85                  90                  95      


Tyr Gly Pro Phe Ser Ile Glu Gln Val Val Pro Gln Asp Leu Met Leu 
            100                 105                 110         


Pro Ser Asn Pro Phe Gly Phe Thr Asn Lys Phe Ser Leu Asn Trp Lys 
        115                 120                 125             


Leu Lys Ala His Ile Leu Arg Asp Lys Val Tyr Leu Ser Arg Pro Lys 
    130                 135                 140                 


Val Gln Val Leu Phe His Ile Met Gly Arg Asp Trp Asp Asp Arg Ser 
145                 150                 155                 160 


Ala Gly Glu Lys Leu Pro Cys Leu Arg Val Phe Ala Phe Arg Glu Thr 
                165                 170                 175     


Arg Glu Val Arg Gly Ser Cys Arg Leu Gln Gly Asp Leu Gly Leu Cys 
            180                 185                 190         


Val Ala Glu Leu Glu Leu Leu Ser Ser Trp Phe Ser Pro Pro Thr Val 
        195                 200                 205             


Val Ala Gly Arg Arg Lys Ser Val Asp Gln Pro Glu Gly Thr Pro Val 
    210                 215                 220                 


Glu Leu Tyr Tyr Thr Val His Pro Gly Gly Glu Arg Gly Asp Cys Val 
225                 230                 235                 240 


Arg Glu Asp Ala Arg Arg Ser Asn Gly Ile Arg Thr Gly His Ser Asp 
                245                 250                 255     


Ile Asp Glu Ser Gly Pro Pro Leu Gln Arg Ile Gly Ser Ile Phe Leu 
            260                 265                 270         


Tyr Gln Thr His Arg Lys Pro Ser Leu Arg Glu Leu Arg Leu Asp Asn 
        275                 280                 285             


Ser Val Ala Ile His Tyr Ile Pro Lys Thr Val Arg Lys Gly Asp Val 
    290                 295                 300                 


Leu Thr Phe Pro Val Ser Ile Ser Arg Asn Ser Thr Glu Asp Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Ala Lys Val Lys Lys Gly Val Asn Ile Ile Gly Val Arg 
                325                 330                 335     


Ala Ser Ser Pro Ser Ile Trp Asp Val Lys Glu Arg Thr Asp Tyr Thr 
            340                 345                 350         


Gly Lys Tyr Ala Pro Ala Val Ile Val Cys Gln Lys Lys Ala Ala Gly 
        355                 360                 365             


Ser Glu Asn Ser Ala Asp Gly Ala Ser Tyr Glu Val Met Gln Ile Asp 
    370                 375                 380                 


Val Glu Val Glu Glu Pro Gly Asp Leu Pro Ala Thr Gln Leu Val Thr 
385                 390                 395                 400 


Trp Gln Val Glu Tyr Pro Gly Glu Ile Thr Ser Asp Leu Gly Val Ser 
                405                 410                 415     


Lys Ile Tyr Val Ser Pro Lys Asp Leu Ile Gly Val Val Pro Leu Ala 
            420                 425                 430         


Met Glu Ala Glu Ile Leu Asn Thr Ala Ile Leu Thr Gly Lys Thr Val 
        435                 440                 445             


Ala Val Pro Val Lys Val Val Ser Val Glu Asp Asp Gly Thr Val Thr 
    450                 455                 460                 


Glu Leu Leu Glu Ser Val Glu Cys Arg Ser Ser Asp Glu Asp Val Ile 
465                 470                 475                 480 


Lys Val Ser Asp Arg Cys Asp Tyr Val Phe Val Asn Gly Lys Glu Met 
                485                 490                 495     


Lys Gly Lys Val Asn Val Val Val Asn Phe Thr Tyr Gln His Leu Ser 
            500                 505                 510         


Ser Pro Leu Glu Met Thr Val Trp Val Pro Arg Leu Pro Leu Gln Ile 
        515                 520                 525             


Glu Val Ser Asp Thr Glu Leu Asn Gln Ile Lys Gly Trp Arg Val Pro 
    530                 535                 540                 


Ile Val Ser Ser Arg Arg Pro Ala Gly Asp Ser Glu Glu Glu Glu Asp 
545                 550                 555                 560 


Asp Glu Arg Arg Gly Arg Gly Cys Thr Leu Gln Tyr Gln His Ala Met 
                565                 570                 575     


Val Arg Val Leu Thr Gln Phe Val Ala Glu Ala Ala Gly Pro Gly Gly 
            580                 585                 590         


His Leu Ala His Leu Leu Gly Ser Asp Trp Gln Val Asp Ile Thr Glu 
        595                 600                 605             


Leu Ile Asn Asp Phe Met Gln Val Glu Glu Pro Arg Ile Ala Lys Leu 
    610                 615                 620                 


Gln Gly Gly Gln Ile Leu Met Gly Gln Glu Leu Gly Met Thr Thr Ile 
625                 630                 635                 640 


Gln Ile Leu Ser Pro Leu Ser Asp Thr Ile Leu Ala Glu Lys Thr Ile 
                645                 650                 655     


Thr Val Leu Asp Glu Lys Val Thr Ile Thr Asp Leu Gly Val Gln Leu 
            660                 665                 670         


Val Thr Gly Leu Ser Leu Ser Leu Gln Leu Ser Pro Gly Ser Asn Arg 
        675                 680                 685             


Ala Ile Phe Ala Thr Ala Val Thr Gln Glu Leu Leu Gln Arg Pro Lys 
    690                 695                 700                 


Gln Glu Ala Ala Ile Ser Cys Trp Val Gln Phe Ser Asp Gly Ser Val 
705                 710                 715                 720 


Thr Pro Leu Asp Ile Tyr Asp Gly Lys Asp Phe Ser Leu Met Ala Thr 
                725                 730                 735     


Ser Leu Asp Glu Lys Val Val Ser Ile His Gln Asp Pro Lys Phe Lys 
            740                 745                 750         


Trp Pro Ile Ile Ala Ala Glu Thr Glu Gly Gln Gly Thr Leu Val Lys 
        755                 760                 765             


Val Glu Met Val Ile Ser Glu Ser Cys Gln Lys Ser Lys Arg Lys Ser 
    770                 775                 780                 


Val Leu Ala Val Gly Thr Ala Asn Ile Lys Val Lys Phe Gly Gln Asn 
785                 790                 795                 800 


Asp Ala Asn Pro Asn Thr Ser Asp Ser Arg His Thr Gly Ala Gly Val 
                805                 810                 815     


His Met Glu Asn Asn Val Ser Asp Arg Arg Pro Lys Lys Pro Ser Gln 
            820                 825                 830         


Glu Trp Gly Ser Gln Glu Gly Gln Tyr Tyr Gly Ser Ser Ser Met Gly 
        835                 840                 845             


Leu Met Glu Gly Arg Gly Thr Thr Thr Asp Arg Ser Ile Leu Gln Lys 
    850                 855                 860                 


Lys Lys Gly Gln Glu Ser Leu Leu Asp Asp Asn Ser His Leu Gln Thr 
865                 870                 875                 880 


Ile Pro Ser Asp Leu Thr Ser Phe Pro Ala Gln Val Asp Leu Pro Arg 
                885                 890                 895     


Ser Asn Gly Glu Met Asp Gly Asn Asp Leu Met Gln Ala Ser Lys Gly 
            900                 905                 910         


Leu Ser Asp Leu Glu Ile Gly Met Tyr Ala Leu Leu Gly Val Phe Cys 
        915                 920                 925             


Leu Ala Ile Leu Val Phe Leu Ile Asn Cys Val Thr Phe Ala Leu Lys 
    930                 935                 940                 


Tyr Arg His Lys Gln Val Pro Phe Glu Glu Gln Glu Gly Met Ser His 
945                 950                 955                 960 


Ser His Asp Trp Val Gly Leu Ser Asn Arg Thr Glu Leu Leu Glu Asn 
                965                 970                 975     


His Ile Asn Phe Ala Ser Ser Gln Asp Glu Gln Ile Thr Ala Ile Asp 
            980                 985                 990         


Arg Gly Met Asp Phe Glu Glu Ser  Lys Tyr Leu Leu Ser  Thr Asn Ser 
        995                 1000                 1005             


Gln Lys  Ser Ile Asn Gly Gln  Leu Phe Lys Pro Leu  Gly Pro Ile 
    1010                 1015                 1020             


Ile Ile  Asp Gly Lys Asp Gln  Lys Ser Glu Pro Pro  Thr Ser Pro 
    1025                 1030                 1035             


Thr Ser  Lys Arg Lys Arg Val  Lys Phe Thr Thr Phe  Thr Ala Val 
    1040                 1045                 1050             


Ser Ser  Asp Asp Glu Tyr Pro  Thr Arg Asn Ser Ile  Val Met Ser 
    1055                 1060                 1065             


Ser Glu  Asp Asp Ile Lys Trp  Val Cys Gln Asp Leu  Asp Pro Gly 
    1070                 1075                 1080             


Asp Cys  Lys Glu Leu His Asn  Tyr Met Glu Arg Leu  His Glu Asn 
    1085                 1090                 1095             


Val 
    


<210>  77
<211>  2351
<212>  DNA
<213>  Homosapiens

<400>  77
agacagtgtt tgtctctcaa gttaaaccaa caagccgata gaaaaaggta gttatcaaga     60

gatttttaaa acttcaaccc tttttctctt atagttagtg aagagagtag aatatctcca    120

gttttggctg acatctctac aacctgaaca attggcttaa acttcacttg ggattcccgg    180

ttgcttgttt tagcatggca aaatttggcg ttcacagaat ccttcttctg gctatttctc    240

tgacaaagtg tctggagagt acaaaactgc tggcagacct taaaaaatgt ggtgacttgg    300

aatgtgaagc tttaataaac agagtctcag ccatgagaga ttatagagga cctgactgcc    360

gatacctgaa cttcactaag ggagaagaga tatctgttta tgttaaactt gcaggagaaa    420

gggaagattt gtgggcagga agtaaaggaa aggagtttgg atattttccc agagatgcag    480

tccagattga agaggtgttc atatctgagg aaattcagat gtcaacgaaa gaatctgact    540

ttctttgtct tcttggagta agttacacat ttgacaatga agatagtgaa ttaaacggtg    600

attatggtga aaatatatat ccttatgaag aagataaaga tgaaaaatct agtatatatg    660

aaagtgattt tcagatagaa cctggatttt atgcaactta tgaaagtact ttgtttgaag    720

accaagttcc agcattagag gctcctgaag atatcggaag taccagtgaa tcaaaagact    780

gggaagaagt agttgttgaa agtatggaac aggatcgtat tccagaagtg catgtcccac    840

catcttcagc tgtgtctgga gtcaaagaat ggtttggatt gggaggagaa caagctgaag    900

agaaggcttt tgaatcagtt attgaacctg tacaagaaag ctcatttcgg agtagaaaaa    960

tagcagtgga agatgagaat gacctagagg aattaaataa tggtgagcct caaacagaac   1020

atcagcaaga atctgaatca gaaattgatt cagtgccaaa gacacagtct gaactagcat   1080

ctgagtcaga gcacattccc aaacctcaat ccactggttg gtttggtgga ggatttacaa   1140

gttatttagg ttttggagat gaggatacag ggcttgaatt aatagctgaa gaaagcaatc   1200

caccactaca agattttccc aattccatat catctgataa agaagccaca gttccatgta   1260

cagaaatatt aacagaaaaa aaagacacaa tcactaatga tagcttgagt ctcaagccaa   1320

gttggtttga ttttggtttt gctatactag gctttgcata tgccaaggaa gataaaatta   1380

tgttagatga caggaaaaat gaagaagatg gtggggcaga tgaacatgaa catcctctaa   1440

caagtgaatt agaccctgaa aaagaacaag aaatagaaac gataaaaatt atagaaacag   1500

aagatcaaat agacaagaaa ccagtctcag aaaaaacaga cgaatctgat actataccat   1560

atttgaaaaa gttcttgtat aattttgaca acccttggaa cttccagaac attccaaagg   1620

aaacagaatt gccatttccc aaacagatac tggatcaaaa taatgtaatt gaaaatgaag   1680

aaactggaga attttccatt gataattatc ccacagataa tacaaaagtt atgatattca   1740

aaagttcata cagtctgtca gatatggtct ctaacataga gttacctacg agaattcacg   1800

aagaagtata ttttgaaccc tcatcttcta aagatagtga tgaaaattcg aaaccatcag   1860

tagacaccga agggcctgct ctggtggaga tagacagatc tgtggaaaat accctgctaa   1920

atagtcagat ggtttcaact gataactctt tgtcttctca aaattatatt tctcagaaag   1980

aagatgcttc tgagtttcag attctgaaat acttattcca aattgatgtt tatgatttca   2040

tgaattctgc attttcacca attgtaattc ttacagaaag ggtaagtttg ccttttaaac   2100

cttttgcaat aattttacct attttgctaa atataagagt ggctacaaaa tatgtttgaa   2160

tgaatcctcc ctgtttaatg tttatataat gtttctcttt ccatgacatc ttacctgtaa   2220

gatttctctt tatatgaatg ttttgtcaaa tggatattga tttttaaaaa catttcccta   2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa a                                                        2351


<210>  78
<211>  654
<212>  PRT
<213>  Homosapiens

<400>  78

Met Ala Lys Phe Gly Val His Arg Ile Leu Leu Leu Ala Ile Ser Leu 
1               5                   10                  15      


Thr Lys Cys Leu Glu Ser Thr Lys Leu Leu Ala Asp Leu Lys Lys Cys 
            20                  25                  30          


Gly Asp Leu Glu Cys Glu Ala Leu Ile Asn Arg Val Ser Ala Met Arg 
        35                  40                  45              


Asp Tyr Arg Gly Pro Asp Cys Arg Tyr Leu Asn Phe Thr Lys Gly Glu 
    50                  55                  60                  


Glu Ile Ser Val Tyr Val Lys Leu Ala Gly Glu Arg Glu Asp Leu Trp 
65                  70                  75                  80  


Ala Gly Ser Lys Gly Lys Glu Phe Gly Tyr Phe Pro Arg Asp Ala Val 
                85                  90                  95      


Gln Ile Glu Glu Val Phe Ile Ser Glu Glu Ile Gln Met Ser Thr Lys 
            100                 105                 110         


Glu Ser Asp Phe Leu Cys Leu Leu Gly Val Ser Tyr Thr Phe Asp Asn 
        115                 120                 125             


Glu Asp Ser Glu Leu Asn Gly Asp Tyr Gly Glu Asn Ile Tyr Pro Tyr 
    130                 135                 140                 


Glu Glu Asp Lys Asp Glu Lys Ser Ser Ile Tyr Glu Ser Asp Phe Gln 
145                 150                 155                 160 


Ile Glu Pro Gly Phe Tyr Ala Thr Tyr Glu Ser Thr Leu Phe Glu Asp 
                165                 170                 175     


Gln Val Pro Ala Leu Glu Ala Pro Glu Asp Ile Gly Ser Thr Ser Glu 
            180                 185                 190         


Ser Lys Asp Trp Glu Glu Val Val Val Glu Ser Met Glu Gln Asp Arg 
        195                 200                 205             


Ile Pro Glu Val His Val Pro Pro Ser Ser Ala Val Ser Gly Val Lys 
    210                 215                 220                 


Glu Trp Phe Gly Leu Gly Gly Glu Gln Ala Glu Glu Lys Ala Phe Glu 
225                 230                 235                 240 


Ser Val Ile Glu Pro Val Gln Glu Ser Ser Phe Arg Ser Arg Lys Ile 
                245                 250                 255     


Ala Val Glu Asp Glu Asn Asp Leu Glu Glu Leu Asn Asn Gly Glu Pro 
            260                 265                 270         


Gln Thr Glu His Gln Gln Glu Ser Glu Ser Glu Ile Asp Ser Val Pro 
        275                 280                 285             


Lys Thr Gln Ser Glu Leu Ala Ser Glu Ser Glu His Ile Pro Lys Pro 
    290                 295                 300                 


Gln Ser Thr Gly Trp Phe Gly Gly Gly Phe Thr Ser Tyr Leu Gly Phe 
305                 310                 315                 320 


Gly Asp Glu Asp Thr Gly Leu Glu Leu Ile Ala Glu Glu Ser Asn Pro 
                325                 330                 335     


Pro Leu Gln Asp Phe Pro Asn Ser Ile Ser Ser Asp Lys Glu Ala Thr 
            340                 345                 350         


Val Pro Cys Thr Glu Ile Leu Thr Glu Lys Lys Asp Thr Ile Thr Asn 
        355                 360                 365             


Asp Ser Leu Ser Leu Lys Pro Ser Trp Phe Asp Phe Gly Phe Ala Ile 
    370                 375                 380                 


Leu Gly Phe Ala Tyr Ala Lys Glu Asp Lys Ile Met Leu Asp Asp Arg 
385                 390                 395                 400 


Lys Asn Glu Glu Asp Gly Gly Ala Asp Glu His Glu His Pro Leu Thr 
                405                 410                 415     


Ser Glu Leu Asp Pro Glu Lys Glu Gln Glu Ile Glu Thr Ile Lys Ile 
            420                 425                 430         


Ile Glu Thr Glu Asp Gln Ile Asp Lys Lys Pro Val Ser Glu Lys Thr 
        435                 440                 445             


Asp Glu Ser Asp Thr Ile Pro Tyr Leu Lys Lys Phe Leu Tyr Asn Phe 
    450                 455                 460                 


Asp Asn Pro Trp Asn Phe Gln Asn Ile Pro Lys Glu Thr Glu Leu Pro 
465                 470                 475                 480 


Phe Pro Lys Gln Ile Leu Asp Gln Asn Asn Val Ile Glu Asn Glu Glu 
                485                 490                 495     


Thr Gly Glu Phe Ser Ile Asp Asn Tyr Pro Thr Asp Asn Thr Lys Val 
            500                 505                 510         


Met Ile Phe Lys Ser Ser Tyr Ser Leu Ser Asp Met Val Ser Asn Ile 
        515                 520                 525             


Glu Leu Pro Thr Arg Ile His Glu Glu Val Tyr Phe Glu Pro Ser Ser 
    530                 535                 540                 


Ser Lys Asp Ser Asp Glu Asn Ser Lys Pro Ser Val Asp Thr Glu Gly 
545                 550                 555                 560 


Pro Ala Leu Val Glu Ile Asp Arg Ser Val Glu Asn Thr Leu Leu Asn 
                565                 570                 575     


Ser Gln Met Val Ser Thr Asp Asn Ser Leu Ser Ser Gln Asn Tyr Ile 
            580                 585                 590         


Ser Gln Lys Glu Asp Ala Ser Glu Phe Gln Ile Leu Lys Tyr Leu Phe 
        595                 600                 605             


Gln Ile Asp Val Tyr Asp Phe Met Asn Ser Ala Phe Ser Pro Ile Val 
    610                 615                 620                 


Ile Leu Thr Glu Arg Val Ser Leu Pro Phe Lys Pro Phe Ala Ile Ile 
625                 630                 635                 640 


Leu Pro Ile Leu Leu Asn Ile Arg Val Ala Thr Lys Tyr Val 
                645                 650                 


<210>  79
<211>  3852
<212>  DNA
<213>  Homosapiens

<400>  79
tgcccggccg aaaccaaacc gaggggtggg gtggcgagga cagggtacgt cgcaggcttg     60

tgcgggtcgg gctcggacct gcgctgcctc gggatgtaaa gtataacaag agggtcggga    120

tgggcagcgt aggcctgtga ggcctgcggg tgcccctgtc ccccagctcc ccccgcagcc    180

ggctccgcag tggtccactc cggttgccgg gtgcggattc gggttccgga ccgaaggctg    240

tgtgttctcc gccgtttatt gtggccccga caggccgggg ttactgtggc gaccacgaga    300

gcagctttgg cgctatggag gagcccgggg ttacccctca accgtatttg gggctgctcc    360

tggaggagct acgcagggtt gtggcagcac tgcctgaagg tatgagacca gattctaatc    420

tttatggttt tccatgggaa ttggtgatat gtgcagctgt tgttggattt tttgctgttc    480

tctttttttt gtggagaagt tttagatcgg ttaggagtcg gctttatgtg ggacgagaga    540

aaaagcttgc tctaatgctt tctggactaa ttgaagaaaa aagtaaacta cttgaaaaat    600

ttagccttgt tcaaaaagag tatgaaggct atgaagtaga gtcatcttta aaggatgcca    660

gctttgagaa ggaggcaaca gaagcacaaa gtttggaggc aacctgtgaa aagctgaaca    720

ggtccaattc tgaacttgag gatgaaatac tctgtctaga aaaagagtta aaagaagaga    780

aatccaaaca ttctgaacaa gatgaattga tggcggatat ttcaaaaagg atacagtctc    840

tagaagatga gtcaaaatcc ctcaaatcac aagtagctga agccaaaatg accttcaaga    900

tatttcaaat gaatgaagaa cgactgaaga tagcaataaa agatgctttg aatgaaaatt    960

ctcaacttca ggaaagccag aaacagcttt tgcaagaagc tgaagtatgg aaagaacaag   1020

tgagtgaact taataaacag aaagtaacat ttgaagactc caaagtacat gcagaacaag   1080

ttctaaatga taaagaaagt cacatcaaga ctctgactga acgcttgtta aagatgaaag   1140

attgggctgc tatgcttgga gaagacataa cggatgatga taacttggaa ttagaaatga   1200

acagtgaatc ggaaaatggt gcttacttag ataatcctcc aaaaggagct ttgaagaaac   1260

tgattcatgc tgctaagtta aatgcttctt taaaaacctt agaaggagaa agaaaccaaa   1320

tttatattca gttgtctgaa gttgataaaa caaaggaaga gcttacagag catattaaaa   1380

atcttcagac tgaacaagca tctttgcagt cagaaaacac acattttgaa aatgagaatc   1440

agaagcttca acagaaactt aaagtaatga ctgaattata tcaagaaaat gaaatgaaac   1500

tccacaggaa attaacagta gaggaaaatt atcggttaga gaaagaagag aaactttcta   1560

aagtagatga aaagatcagc catgccactg aagagctgga gacctataga aagcgagcca   1620

aagatcttga agaagaattg gagagaacta ttcattctta tcaagggcag attatttccc   1680

atgagaaaaa agcacatgat aattggttgg cagctcggaa tgctgaaaga aacctcaatg   1740

atttaaggaa agaaaatgct cacaacagac aaaaattaac tgaaacagag cttaaatttg   1800

aacttttaga aaaagatcct tatgcactcg atgttccaaa tacagcattt ggcagagagc   1860

attccccata tggtccctca ccattgggtt ggccttcatc tgaaacaaga gcttttctct   1920

ctcctccaac tttgttggag ggtccactca gactctcacc tttgcttcca gggggaggag   1980

gaagaggctc acgaggccca gggaatcctc tggaccatca gattaccaat gaaagaggag   2040

aatcaagctg tgataggtta accgatcctc atagggctcc ctctgacact gggtctctgt   2100

cacctccatg ggaccaggac cgtaggatga tgtttcctcc gccaggacaa tcatatcctg   2160

attcagccct tcctccacaa aggcaagaca gattttgttc taattctggt agactgtctg   2220

gaccagcaga actcagaagt tttaatatgc cttctttgga taaaatggat gggtcaatgc   2280

cttcagaaat ggaatccagt agaaatgata ccaaagatga tcttggtaat ttaaatgtgc   2340

ctgattcatc tctccctgct gaaaatgaag ccactggccc tggctttgtt cctccacctc   2400

ttgctccaat cagaggtcca ttgtttccag tggatgcaag aggcccattc ttgagaagag   2460

gacctccttt ccccccacct cctccaggag ccatgtttgg agcttctcga gattattttc   2520

caccagggga tttcccaggt ccaccacctg ctccatttgc aatgagaaat gtctatccac   2580

cgaggggttt tcctccttac cttcccccaa gacctggatt tttcccccca cccccacatt   2640

ctgaaggtag aagtgagttc ccctcaggtt tgattccacc ttcaaatgag cctgctactg   2700

aacatccaga accacagcaa gaaacctgac aatatttttg ctctcttcaa aagtaatttt   2760

gactgatctc attttcagtt taagtaactg ctgttactta agtgattaca cttttgctca   2820

aattgaagct taatggaatt ataattctca ggatagtatt ttgtaaataa agatgattta   2880

aatatgaatc ttatgagtaa attatttcaa ttttatttta gacggtataa ctatttcaat   2940

ttgattaatc cactattata taaacaatag tgggagtttt atatatgtaa tctttcaggt   3000

ggggaggctt taaattctga agtctgtgtc tttatgccaa gaactgtatt tactgtggtt   3060

gtggacaaat gtgaaagtaa ctttatgctt aaataaatta tagttgattt aaagatttgt   3120

ttggcattga taataataaa atcagtagtt tttctataac tatggctcta ttaacttttt   3180

tccttttacc aataactttg aggtgcaaaa ctcaaactta tgtgggtctt ttgtgttcaa   3240

ttatgttatg acaaatgtgc tctctttctt gtaaatagac atgagtggcc caaagcaaca   3300

aattaataca cttttaaaag tcaaaattga ttatatttta aagataacca ggatattatc   3360

taatggtgaa ttgtagaatt ttgatcttct tattcactga gtttcttgca cggtttcttt   3420

attgcttttt tttccccgcc tgttcttttg taaggtattt actattttct gtggaggata   3480

ttgagatgta ctacaggata actgtagtga atgatgtgtc atcattttga gctttggact   3540

caatatcttt agtgtttccc taaatcagat ttgtaggtca tgttaagctt cttgcacatt   3600

aatatgatta tggaaggaaa ggcagtgaag cataactaat aaacatcata atacttaacg   3660

ttgcccagtt ggttgtttta gtattagact tttttttcaa tgccaaaaga tagaagatta   3720

aatattcttg aataaagcag tgatatatat tggaacactt caccccagca tttccccagg   3780

tgttgtttgg aacactgatc ttgtgaagta tttttgctcc ctttctattc taaccctcac   3840

ctcaaaaaaa aa                                                       3852


<210>  80
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  80

Met Glu Glu Pro Gly Val Thr Pro Gln Pro Tyr Leu Gly Leu Leu Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Val Val Ala Ala Leu Pro Glu Gly Met Arg Pro 
            20                  25                  30          


Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val Ile Cys Ala Ala 
        35                  40                  45              


Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys Lys Leu Ala Leu 
65                  70                  75                  80  


Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser Leu Glu 
        115                 120                 125             


Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu Glu Asp Glu 
    130                 135                 140                 


Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser Lys His Ser 
145                 150                 155                 160 


Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Arg Ile Gln Ser Leu 
                165                 170                 175     


Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu Ala Lys Met 
            180                 185                 190         


Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg Leu Lys Ile Ala Ile 
        195                 200                 205             


Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Glu Ser Gln Lys Gln 
    210                 215                 220                 


Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser Glu Leu Asn 
225                 230                 235                 240 


Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val His Ala Glu Gln Val 
                245                 250                 255     


Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu Thr Glu Arg Leu Leu 
            260                 265                 270         


Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu Asp Ile Thr Asp Asp 
        275                 280                 285             


Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asn Gly Ala Tyr 
    290                 295                 300                 


Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg Asn Gln Ile 
                325                 330                 335     


Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu Thr Glu 
            340                 345                 350         


His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln Ser Glu Asn 
        355                 360                 365             


Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln Gln Lys Leu Lys Val 
    370                 375                 380                 


Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu His Arg Lys Leu 
385                 390                 395                 400 


Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu Glu Lys Leu Ser Lys 
                405                 410                 415     


Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu Leu Glu Thr Tyr Arg 
            420                 425                 430         


Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Ile His Ser 
        435                 440                 445             


Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys Ala His Asp Asn Trp 
    450                 455                 460                 


Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn Asp Leu Arg Lys Glu 
465                 470                 475                 480 


Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr Glu Leu Lys Phe Glu 
                485                 490                 495     


Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val Pro Asn Thr Ala Phe 
            500                 505                 510         


Gly Arg Glu His Ser Pro Tyr Gly Pro Ser Pro Leu Gly Trp Pro Ser 
        515                 520                 525             


Ser Glu Thr Arg Ala Phe Leu Ser Pro Pro Thr Leu Leu Glu Gly Pro 
    530                 535                 540                 


Leu Arg Leu Ser Pro Leu Leu Pro Gly Gly Gly Gly Arg Gly Ser Arg 
545                 550                 555                 560 


Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu Arg Gly Glu 
                565                 570                 575     


Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro Ser Asp Thr 
            580                 585                 590         


Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg Arg Met Met Phe Pro 
        595                 600                 605             


Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro Gln Arg Gln 
    610                 615                 620                 


Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser Gly Pro Ala Glu Leu 
625                 630                 635                 640 


Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met Asp Gly Ser Met Pro 
                645                 650                 655     


Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys Asp Asp Leu Gly Asn 
            660                 665                 670         


Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala Thr Gly 
        675                 680                 685             


Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile Arg Gly Pro Leu Phe 
    690                 695                 700                 


Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg Gly Pro Pro Phe Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser Arg Asp Tyr Phe Pro 
                725                 730                 735     


Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro Phe Ala Met Arg Asn 
            740                 745                 750         


Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu Pro Pro Arg Pro Gly 
        755                 760                 765             


Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg Ser Glu Phe Pro Ser 
    770                 775                 780                 


Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr Glu His Pro Glu Pro 
785                 790                 795                 800 


Gln Gln Glu Thr 
                


<210>  81
<211>  3723
<212>  DNA
<213>  Homosapiens

<400>  81
tgcccggccg aaaccaaacc gaggggtggg gtggcgagga cagggtacgt cgcaggcttg     60

tgcgggtcgg gctcggacct gcgctgcctc gggatgtaaa gtataacaag agggtcggga    120

tgggcagcgt aggcctgtga ggcctgcggg tgcccctgtc ccccagctcc ccccgcagcc    180

ggctccgcag tggtccactc cggttgccgg gtgcggattc gggttccgga ccgaaggctg    240

tgtgttctcc gccgtttatt gtggccccga caggccgggg ttactgtggc gaccacgaga    300

gcagctttgg cgctatggag gagcccgggg ttacccctca accgtatttg gggctgctcc    360

tggaggagct acgcagggtt gtggcagcac tgcctgaagg tatgagacca gattctaatc    420

tttatggttt tccatgggaa ttggtgatat gtgcagctgt tgttggattt tttgctgttc    480

tctttttttt gtggagaagt tttagatcgg ttaggagtcg gctttatgtg ggacgagaga    540

aaaagcttgc tctaatgctt tctggactaa ttgaagaaaa aagtaaacta cttgaaaaat    600

ttagccttgt tcaaaaagag tatgaaggct atgaagtaga gtcatcttta aaggatgcca    660

gctttgagaa ggaggcaaca gaagcacaaa gtttggaggc aacctgtgaa aagctgaaca    720

ggtccaattc tgaacttgag gatgaaatac tctgtctaga aaaagagtta aaagaagaga    780

aatccaaaca ttctgaacaa gatgaattga tggcggatat ttcaaaaagg atacagtctc    840

tagaagatga gtcaaaatcc ctcaaatcac aagtagctga agccaaaatg accttcaaga    900

tatttcaaat gaatgaagaa cgactgaaga tagcaataaa agatgctttg aatgaaaatt    960

ctcaacttca ggaaagccag aaacagcttt tgcaagaagc tgaagtatgg aaagaacaag   1020

tgagtgaact taataaacag aaagtaacat ttgaagactc caaagtacat gcagaacaag   1080

ttctaaatga taaagaaagt cacatcaaga ctctgactga acgcttgtta aagatgaaag   1140

attgggctgc tatgcttgga gaagacataa cggatgatga taacttggaa ttagaaatga   1200

acagtgaatc ggaaaatggt gcttacttag ataatcctcc aaaaggagct ttgaagaaac   1260

tgattcatgc tgctaagtta aatgcttctt taaaaacctt agaaggagaa agaaaccaaa   1320

tttatattca gttgtctgaa gttgataaaa caaaggaaga gcttacagag catattaaaa   1380

atcttcagac tgaacaagca tctttgcagt cagaaaacac acattttgaa aatgagaatc   1440

agaagcttca acagaaactt aaagtaatga ctgaattata tcaagaaaat gaaatgaaac   1500

tccacaggaa attaacagta gaggaaaatt atcggttaga gaaagaagag aaactttcta   1560

aagtagatga aaagatcagc catgccactg aagagctgga gacctataga aagcgagcca   1620

aagatcttga agaagaattg gagagaacta ttcattctta tcaagggcag attatttccc   1680

atgagaaaaa agcacatgat aattggttgg cagctcggaa tgctgaaaga aacctcaatg   1740

atttaaggaa agaaaatgct cacaacagac aaaaattaac tgaaacagag cttaaatttg   1800

aacttttaga aaaagatcct tatgcactcg atgttccaaa tacagcattt ggcagaggct   1860

cacgaggccc agggaatcct ctggaccatc agattaccaa tgaaagagga gaatcaagct   1920

gtgataggtt aaccgatcct catagggctc cctctgacac tgggtctctg tcacctccat   1980

gggaccagga ccgtaggatg atgtttcctc cgccaggaca atcatatcct gattcagccc   2040

ttcctccaca aaggcaagac agattttgtt ctaattctgg tagactgtct ggaccagcag   2100

aactcagaag ttttaatatg ccttctttgg ataaaatgga tgggtcaatg ccttcagaaa   2160

tggaatccag tagaaatgat accaaagatg atcttggtaa tttaaatgtg cctgattcat   2220

ctctccctgc tgaaaatgaa gccactggcc ctggctttgt tcctccacct cttgctccaa   2280

tcagaggtcc attgtttcca gtggatgcaa gaggcccatt cttgagaaga ggacctcctt   2340

tccccccacc tcctccagga gccatgtttg gagcttctcg agattatttt ccaccagggg   2400

atttcccagg tccaccacct gctccatttg caatgagaaa tgtctatcca ccgaggggtt   2460

ttcctcctta ccttccccca agacctggat ttttcccccc acccccacat tctgaaggta   2520

gaagtgagtt cccctcaggt ttgattccac cttcaaatga gcctgctact gaacatccag   2580

aaccacagca agaaacctga caatattttt gctctcttca aaagtaattt tgactgatct   2640

cattttcagt ttaagtaact gctgttactt aagtgattac acttttgctc aaattgaagc   2700

ttaatggaat tataattctc aggatagtat tttgtaaata aagatgattt aaatatgaat   2760

cttatgagta aattatttca attttatttt agacggtata actatttcaa tttgattaat   2820

ccactattat ataaacaata gtgggagttt tatatatgta atctttcagg tggggaggct   2880

ttaaattctg aagtctgtgt ctttatgcca agaactgtat ttactgtggt tgtggacaaa   2940

tgtgaaagta actttatgct taaataaatt atagttgatt taaagatttg tttggcattg   3000

ataataataa aatcagtagt ttttctataa ctatggctct attaactttt ttccttttac   3060

caataacttt gaggtgcaaa actcaaactt atgtgggtct tttgtgttca attatgttat   3120

gacaaatgtg ctctctttct tgtaaataga catgagtggc ccaaagcaac aaattaatac   3180

acttttaaaa gtcaaaattg attatatttt aaagataacc aggatattat ctaatggtga   3240

attgtagaat tttgatcttc ttattcactg agtttcttgc acggtttctt tattgctttt   3300

ttttccccgc ctgttctttt gtaaggtatt tactattttc tgtggaggat attgagatgt   3360

actacaggat aactgtagtg aatgatgtgt catcattttg agctttggac tcaatatctt   3420

tagtgtttcc ctaaatcaga tttgtaggtc atgttaagct tcttgcacat taatatgatt   3480

atggaaggaa aggcagtgaa gcataactaa taaacatcat aatacttaac gttgcccagt   3540

tggttgtttt agtattagac ttttttttca atgccaaaag atagaagatt aaatattctt   3600

gaataaagca gtgatatata ttggaacact tcaccccagc atttccccag gtgttgtttg   3660

gaacactgat cttgtgaagt atttttgctc cctttctatt ctaaccctca cctcaaaaaa   3720

aaa                                                                 3723


<210>  82
<211>  761
<212>  PRT
<213>  Homosapiens

<400>  82

Met Glu Glu Pro Gly Val Thr Pro Gln Pro Tyr Leu Gly Leu Leu Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Val Val Ala Ala Leu Pro Glu Gly Met Arg Pro 
            20                  25                  30          


Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val Ile Cys Ala Ala 
        35                  40                  45              


Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys Lys Leu Ala Leu 
65                  70                  75                  80  


Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser Leu Glu 
        115                 120                 125             


Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu Glu Asp Glu 
    130                 135                 140                 


Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser Lys His Ser 
145                 150                 155                 160 


Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Arg Ile Gln Ser Leu 
                165                 170                 175     


Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu Ala Lys Met 
            180                 185                 190         


Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg Leu Lys Ile Ala Ile 
        195                 200                 205             


Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Glu Ser Gln Lys Gln 
    210                 215                 220                 


Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser Glu Leu Asn 
225                 230                 235                 240 


Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val His Ala Glu Gln Val 
                245                 250                 255     


Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu Thr Glu Arg Leu Leu 
            260                 265                 270         


Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu Asp Ile Thr Asp Asp 
        275                 280                 285             


Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asn Gly Ala Tyr 
    290                 295                 300                 


Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg Asn Gln Ile 
                325                 330                 335     


Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu Thr Glu 
            340                 345                 350         


His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln Ser Glu Asn 
        355                 360                 365             


Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln Gln Lys Leu Lys Val 
    370                 375                 380                 


Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu His Arg Lys Leu 
385                 390                 395                 400 


Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu Glu Lys Leu Ser Lys 
                405                 410                 415     


Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu Leu Glu Thr Tyr Arg 
            420                 425                 430         


Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Ile His Ser 
        435                 440                 445             


Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys Ala His Asp Asn Trp 
    450                 455                 460                 


Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn Asp Leu Arg Lys Glu 
465                 470                 475                 480 


Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr Glu Leu Lys Phe Glu 
                485                 490                 495     


Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val Pro Asn Thr Ala Phe 
            500                 505                 510         


Gly Arg Gly Ser Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr 
        515                 520                 525             


Asn Glu Arg Gly Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg 
    530                 535                 540                 


Ala Pro Ser Asp Thr Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg 
545                 550                 555                 560 


Arg Met Met Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu 
                565                 570                 575     


Pro Pro Gln Arg Gln Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser 
            580                 585                 590         


Gly Pro Ala Glu Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met 
        595                 600                 605             


Asp Gly Ser Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys 
    610                 615                 620                 


Asp Asp Leu Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu 
625                 630                 635                 640 


Asn Glu Ala Thr Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile 
                645                 650                 655     


Arg Gly Pro Leu Phe Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg 
            660                 665                 670         


Gly Pro Pro Phe Pro Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser 
        675                 680                 685             


Arg Asp Tyr Phe Pro Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro 
    690                 695                 700                 


Phe Ala Met Arg Asn Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu 
705                 710                 715                 720 


Pro Pro Arg Pro Gly Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg 
                725                 730                 735     


Ser Glu Phe Pro Ser Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr 
            740                 745                 750         


Glu His Pro Glu Pro Gln Gln Glu Thr 
        755                 760     


<210>  83
<211>  4303
<212>  DNA
<213>  Homosapiens

<400>  83
atgttcagac acatttaaga atttttattg agtaatacaa tgttctaatt gaggcataca     60

cgttgttcta ggagtctgtg aaattctaaa gataaaagtt tgattatgct tgttttgact    120

ttaatgaact attcacataa ttttaataca cagtgtctaa cacgtatgaa agttgtgtaa    180

taccttatac cttaacaatg gagaattact aagcaatttt ggctactctg atattagcat    240

ttcctgaaac tcctcaggct gatgtggcaa aggagaaata gcaatcttga gttctgaaaa    300

gctaggccgc attttggtcc tgaaaaatca cttgctgtga acttgggcca gtttttgatt    360

ttttaaatgg cataacagtt cgttgctaca agaggttaca tcaggaaaat ttcctaagga    420

tttaagattt tgttcatcta ttgagttctt ttgggtgatt tgtttaggag gaagtatctg    480

ctcctttttg agttgcttca ccaaagtact tgagtgagaa ggcagaatat aatgagaatg    540

atcatgctgg caaggaagac atatatatga gatgggttat cctttacacc tacgtcagct    600

aaaaccgtct cctacgaaca aatccagcac ttggcacttt attcgacggt cctaaaaata    660

gagtcctaaa tttagaaggc aaggtgctac ttttagctcc tcttctcgga ggaaaacagc    720

acgcaccgcg ccaggccaag gtccacgggg atttgattta gcatttgggt aactggccgc    780

taatggaact gaagacagct gggcctaaca agtgcccagg tgactcaggt tgtggcagca    840

ctgcctgaag gtatgagacc agattctaat ctttatggtt ttccatggga attggtgata    900

tgtgcagctg ttgttggatt ttttgctgtt ctcttttttt tgtggagaag ttttagatcg    960

gttaggagtc ggctttatgt gggacgagag aaaaagcttg ctctaatgct ttctggacta   1020

attgaagaaa aaagtaaact acttgaaaaa tttagccttg ttcaaaaaga gtatgaaggc   1080

tatgaagtag agtcatcttt aaaggatgcc agctttgaga aggaggcaac agaagcacaa   1140

agtttggagg caacctgtga aaagctgaac aggtccaatt ctgaacttga ggatgaaata   1200

ctctgtctag aaaaagagtt aaaagaagag aaatccaaac attctgaaca agatgaattg   1260

atggcggata tttcaaaaag gatacagtct ctagaagatg agtcaaaatc cctcaaatca   1320

caagtagctg aagccaaaat gaccttcaag atatttcaaa tgaatgaaga acgactgaag   1380

atagcaataa aagatgcttt gaatgaaaat tctcaacttc aggaaagcca gaaacagctt   1440

ttgcaagaag ctgaagtatg gaaagaacaa gtgagtgaac ttaataaaca gaaagtaaca   1500

tttgaagact ccaaagtaca tgcagaacaa gttctaaatg ataaagaaag tcacatcaag   1560

actctgactg aacgcttgtt aaagatgaaa gattgggctg ctatgcttgg agaagacata   1620

acggatgatg ataacttgga attagaaatg aacagtgaat cggaaaatgg tgcttactta   1680

gataatcctc caaaaggagc tttgaagaaa ctgattcatg ctgctaagtt aaatgcttct   1740

ttaaaaacct tagaaggaga aagaaaccaa atttatattc agttgtctga agttgataaa   1800

acaaaggaag agcttacaga gcatattaaa aatcttcaga ctgaacaagc atctttgcag   1860

tcagaaaaca cacattttga aaatgagaat cagaagcttc aacagaaact taaagtaatg   1920

actgaattat atcaagaaaa tgaaatgaaa ctccacagga aattaacagt agaggaaaat   1980

tatcggttag agaaagaaga gaaactttct aaagtagatg aaaagatcag ccatgccact   2040

gaagagctgg agacctatag aaagcgagcc aaagatcttg aagaagaatt ggagagaact   2100

attcattctt atcaagggca gattatttcc catgagaaaa aagcacatga taattggttg   2160

gcagctcgga atgctgaaag aaacctcaat gatttaagga aagaaaatgc tcacaacaga   2220

caaaaattaa ctgaaacaga gcttaaattt gaacttttag aaaaagatcc ttatgcactc   2280

gatgttccaa atacagcatt tggcagagag cattccccat atggtccctc accattgggt   2340

tggccttcat ctgaaacaag agcttttctc tctcctccaa ctttgttgga gggtccactc   2400

agactctcac ctttgcttcc agggggagga ggaagaggct cacgaggccc agggaatcct   2460

ctggaccatc agattaccaa tgaaagagga gaatcaagct gtgataggtt aaccgatcct   2520

catagggctc cctctgacac tgggtctctg tcacctccat gggaccagga ccgtaggatg   2580

atgtttcctc cgccaggaca atcatatcct gattcagccc ttcctccaca aaggcaagac   2640

agattttgtt ctaattctgg tagactgtct ggaccagcag aactcagaag ttttaatatg   2700

ccttctttgg ataaaatgga tgggtcaatg ccttcagaaa tggaatccag tagaaatgat   2760

accaaagatg atcttggtaa tttaaatgtg cctgattcat ctctccctgc tgaaaatgaa   2820

gccactggcc ctggctttgt tcctccacct cttgctccaa tcagaggtcc attgtttcca   2880

gtggatgcaa gaggcccatt cttgagaaga ggacctcctt tccccccacc tcctccagga   2940

gccatgtttg gagcttctcg agattatttt ccaccagggg atttcccagg tccaccacct   3000

gctccatttg caatgagaaa tgtctatcca ccgaggggtt ttcctcctta ccttccccca   3060

agacctggat ttttcccccc acccccacat tctgaaggta gaagtgagtt cccctcaggt   3120

ttgattccac cttcaaatga gcctgctact gaacatccag aaccacagca agaaacctga   3180

caatattttt gctctcttca aaagtaattt tgactgatct cattttcagt ttaagtaact   3240

gctgttactt aagtgattac acttttgctc aaattgaagc ttaatggaat tataattctc   3300

aggatagtat tttgtaaata aagatgattt aaatatgaat cttatgagta aattatttca   3360

attttatttt agacggtata actatttcaa tttgattaat ccactattat ataaacaata   3420

gtgggagttt tatatatgta atctttcagg tggggaggct ttaaattctg aagtctgtgt   3480

ctttatgcca agaactgtat ttactgtggt tgtggacaaa tgtgaaagta actttatgct   3540

taaataaatt atagttgatt taaagatttg tttggcattg ataataataa aatcagtagt   3600

ttttctataa ctatggctct attaactttt ttccttttac caataacttt gaggtgcaaa   3660

actcaaactt atgtgggtct tttgtgttca attatgttat gacaaatgtg ctctctttct   3720

tgtaaataga catgagtggc ccaaagcaac aaattaatac acttttaaaa gtcaaaattg   3780

attatatttt aaagataacc aggatattat ctaatggtga attgtagaat tttgatcttc   3840

ttattcactg agtttcttgc acggtttctt tattgctttt ttttccccgc ctgttctttt   3900

gtaaggtatt tactattttc tgtggaggat attgagatgt actacaggat aactgtagtg   3960

aatgatgtgt catcattttg agctttggac tcaatatctt tagtgtttcc ctaaatcaga   4020

tttgtaggtc atgttaagct tcttgcacat taatatgatt atggaaggaa aggcagtgaa   4080

gcataactaa taaacatcat aatacttaac gttgcccagt tggttgtttt agtattagac   4140

ttttttttca atgccaaaag atagaagatt aaatattctt gaataaagca gtgatatata   4200

ttggaacact tcaccccagc atttccccag gtgttgtttg gaacactgat cttgtgaagt   4260

atttttgctc cctttctatt ctaaccctca cctcaaaaaa aaa                     4303


<210>  84
<211>  775
<212>  PRT
<213>  Homosapiens

<400>  84

Met Arg Pro Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val Ile 
1               5                   10                  15      


Cys Ala Ala Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp Arg 
            20                  25                  30          


Ser Phe Arg Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys Lys 
        35                  40                  45              


Leu Ala Leu Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu 
    50                  55                  60                  


Glu Lys Phe Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu 
65                  70                  75                  80  


Ser Ser Leu Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln 
                85                  90                  95      


Ser Leu Glu Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu 
            100                 105                 110         


Glu Asp Glu Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser 
        115                 120                 125             


Lys His Ser Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Arg Ile 
    130                 135                 140                 


Gln Ser Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu 
145                 150                 155                 160 


Ala Lys Met Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg Leu Lys 
                165                 170                 175     


Ile Ala Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Glu Ser 
            180                 185                 190         


Gln Lys Gln Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser 
        195                 200                 205             


Glu Leu Asn Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val His Ala 
    210                 215                 220                 


Glu Gln Val Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu Thr Glu 
225                 230                 235                 240 


Arg Leu Leu Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu Asp Ile 
                245                 250                 255     


Thr Asp Asp Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asn 
            260                 265                 270         


Gly Ala Tyr Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile 
        275                 280                 285             


His Ala Ala Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg 
    290                 295                 300                 


Asn Gln Ile Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu 
305                 310                 315                 320 


Leu Thr Glu His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln 
                325                 330                 335     


Ser Glu Asn Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln Gln Lys 
            340                 345                 350         


Leu Lys Val Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu His 
        355                 360                 365             


Arg Lys Leu Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu Glu Lys 
    370                 375                 380                 


Leu Ser Lys Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu Leu Glu 
385                 390                 395                 400 


Thr Tyr Arg Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr 
                405                 410                 415     


Ile His Ser Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys Ala His 
            420                 425                 430         


Asp Asn Trp Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn Asp Leu 
        435                 440                 445             


Arg Lys Glu Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr Glu Leu 
    450                 455                 460                 


Lys Phe Glu Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val Pro Asn 
465                 470                 475                 480 


Thr Ala Phe Gly Arg Glu His Ser Pro Tyr Gly Pro Ser Pro Leu Gly 
                485                 490                 495     


Trp Pro Ser Ser Glu Thr Arg Ala Phe Leu Ser Pro Pro Thr Leu Leu 
            500                 505                 510         


Glu Gly Pro Leu Arg Leu Ser Pro Leu Leu Pro Gly Gly Gly Gly Arg 
        515                 520                 525             


Gly Ser Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu 
    530                 535                 540                 


Arg Gly Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro 
545                 550                 555                 560 


Ser Asp Thr Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg Arg Met 
                565                 570                 575     


Met Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro 
            580                 585                 590         


Gln Arg Gln Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser Gly Pro 
        595                 600                 605             


Ala Glu Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met Asp Gly 
    610                 615                 620                 


Ser Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys Asp Asp 
625                 630                 635                 640 


Leu Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu 
                645                 650                 655     


Ala Thr Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile Arg Gly 
            660                 665                 670         


Pro Leu Phe Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg Gly Pro 
        675                 680                 685             


Pro Phe Pro Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser Arg Asp 
    690                 695                 700                 


Tyr Phe Pro Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro Phe Ala 
705                 710                 715                 720 


Met Arg Asn Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu Pro Pro 
                725                 730                 735     


Arg Pro Gly Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg Ser Glu 
            740                 745                 750         


Phe Pro Ser Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr Glu His 
        755                 760                 765             


Pro Glu Pro Gln Gln Glu Thr 
    770                 775 


<210>  85
<211>  3757
<212>  DNA
<213>  Homosapiens

<400>  85
tgcccggccg aaaccaaacc gaggggtggg gtggcgagga cagggtacgt cgcaggcttg     60

tgcgggtcgg gctcggacct gcgctgcctc gggatgtaaa gtataacaag agggtcggga    120

tgggcagcgt aggcctgtga ggcctgcggg tgcccctgtc ccccagctcc ccccgcagcc    180

ggctccgcag tggtccactc cggttgccgg gtgcggattc gggttccgga ccgaaggctg    240

tgtgttctcc gccgtttatt gtggccccga caggccgggg ttactgtggc gaccacgaga    300

gcagctttgg cgctatggag gagcccgggg ttacccctca accgtatttg gggctgctcc    360

tggaggagct acgcagggtt gtggcagcac tgcctgaagg ttaggagtcg gctttatgtg    420

ggacgagaga aaaagcttgc tctaatgctt tctggactaa ttgaagaaaa aagtaaacta    480

cttgaaaaat ttagccttgt tcaaaaagag tatgaaggct atgaagtaga gtcatcttta    540

aaggatgcca gctttgagaa ggaggcaaca gaagcacaaa gtttggaggt agaaaatcaa    600

atggcaacct gtgaaaagct gaacaggtcc aattctgaac ttgaggatga aatactctgt    660

ctagaaaaag agttaaaaga agagaaatcc aaacattctg aacaagatga attgatggcg    720

gatatttcaa aaaggataca gtctctagaa gatgagtcaa aatccctcaa atcacaagta    780

gctgaagcca aaatgacctt caagatattt caaatgaatg aagaacgact gaagatagca    840

ataaaagatg ctttgaatga aaattctcaa cttcaggaaa gccagaaaca gcttttgcaa    900

gaagctgaag tatggaaaga acaagtgagt gaacttaata aacagaaagt aacatttgaa    960

gactccaaag tacatgcaga acaagttcta aatgataaag aaagtcacat caagactctg   1020

actgaacgct tgttaaagat gaaagattgg gctgctatgc ttggagaaga cataacggat   1080

gatgataact tggaattaga aatgaacagt gaatcggaaa atggtgctta cttagataat   1140

cctccaaaag gagctttgaa gaaactgatt catgctgcta agttaaatgc ttctttaaaa   1200

accttagaag gagaaagaaa ccaaatttat attcagttgt ctgaagttga taaaacaaag   1260

gaagagctta cagagcatat taaaaatctt cagactgaac aagcatcttt gcagtcagaa   1320

aacacacatt ttgaaaatga gaatcagaag cttcaacaga aacttaaagt aatgactgaa   1380

ttatatcaag aaaatgaaat gaaactccac aggaaattaa cagtagagga aaattatcgg   1440

ttagagaaag aagagaaact ttctaaagta gatgaaaaga tcagccatgc cactgaagag   1500

ctggagacct atagaaagcg agccaaagat cttgaagaag aattggagag aactattcat   1560

tcttatcaag ggcagattat ttcccatgag aaaaaagcac atgataattg gttggcagct   1620

cggaatgctg aaagaaacct caatgattta aggaaagaaa atgctcacaa cagacaaaaa   1680

ttaactgaaa cagagcttaa atttgaactt ttagaaaaag atccttatgc actcgatgtt   1740

ccaaatacag catttggcag agagcattcc ccatatggtc cctcaccatt gggttggcct   1800

tcatctgaaa caagagcttt tctctctcct ccaactttgt tggagggtcc actcagactc   1860

tcacctttgc ttccaggggg aggaggaaga ggctcacgag gcccagggaa tcctctggac   1920

catcagatta ccaatgaaag aggagaatca agctgtgata ggttaaccga tcctcatagg   1980

gctccctctg acactgggtc tctgtcacct ccatgggacc aggaccgtag gatgatgttt   2040

cctccgccag gacaatcata tcctgattca gcccttcctc cacaaaggca agacagattt   2100

tgttctaatt ctggtagact gtctggacca gcagaactca gaagttttaa tatgccttct   2160

ttggataaaa tggatgggtc aatgccttca gaaatggaat ccagtagaaa tgataccaaa   2220

gatgatcttg gtaatttaaa tgtgcctgat tcatctctcc ctgctgaaaa tgaagccact   2280

ggccctggct ttgttcctcc acctcttgct ccaatcagag gtccattgtt tccagtggat   2340

gcaagaggcc cattcttgag aagaggacct cctttccccc cacctcctcc aggagccatg   2400

tttggagctt ctcgagatta ttttccacca ggggatttcc caggtccacc acctgctcca   2460

tttgcaatga gaaatgtcta tccaccgagg ggttttcctc cttaccttcc cccaagacct   2520

ggatttttcc ccccaccccc acattctgaa ggtagaagtg agttcccctc aggtttgatt   2580

ccaccttcaa atgagcctgc tactgaacat ccagaaccac agcaagaaac ctgacaatat   2640

ttttgctctc ttcaaaagta attttgactg atctcatttt cagtttaagt aactgctgtt   2700

acttaagtga ttacactttt gctcaaattg aagcttaatg gaattataat tctcaggata   2760

gtattttgta aataaagatg atttaaatat gaatcttatg agtaaattat ttcaatttta   2820

ttttagacgg tataactatt tcaatttgat taatccacta ttatataaac aatagtggga   2880

gttttatata tgtaatcttt caggtgggga ggctttaaat tctgaagtct gtgtctttat   2940

gccaagaact gtatttactg tggttgtgga caaatgtgaa agtaacttta tgcttaaata   3000

aattatagtt gatttaaaga tttgtttggc attgataata ataaaatcag tagtttttct   3060

ataactatgg ctctattaac ttttttcctt ttaccaataa ctttgaggtg caaaactcaa   3120

acttatgtgg gtcttttgtg ttcaattatg ttatgacaaa tgtgctctct ttcttgtaaa   3180

tagacatgag tggcccaaag caacaaatta atacactttt aaaagtcaaa attgattata   3240

ttttaaagat aaccaggata ttatctaatg gtgaattgta gaattttgat cttcttattc   3300

actgagtttc ttgcacggtt tctttattgc ttttttttcc ccgcctgttc ttttgtaagg   3360

tatttactat tttctgtgga ggatattgag atgtactaca ggataactgt agtgaatgat   3420

gtgtcatcat tttgagcttt ggactcaata tctttagtgt ttccctaaat cagatttgta   3480

ggtcatgtta agcttcttgc acattaatat gattatggaa ggaaaggcag tgaagcataa   3540

ctaataaaca tcataatact taacgttgcc cagttggttg ttttagtatt agactttttt   3600

ttcaatgcca aaagatagaa gattaaatat tcttgaataa agcagtgata tatattggaa   3660

cacttcaccc cagcatttcc ccaggtgttg tttggaacac tgatcttgtg aagtattttt   3720

gctccctttc tattctaacc ctcacctcaa aaaaaaa                            3757


<210>  86
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  86

Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu Glu Lys Phe 
1               5                   10                  15      


Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            20                  25                  30          


Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser Leu Glu 
        35                  40                  45              


Val Glu Asn Gln Met Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser 
    50                  55                  60                  


Glu Leu Glu Asp Glu Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu 
65                  70                  75                  80  


Lys Ser Lys His Ser Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys 
                85                  90                  95      


Arg Ile Gln Ser Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val 
            100                 105                 110         


Ala Glu Ala Lys Met Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg 
        115                 120                 125             


Leu Lys Ile Ala Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gln Lys Gln Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln 
145                 150                 155                 160 


Val Ser Glu Leu Asn Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val 
                165                 170                 175     


His Ala Glu Gln Val Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu 
            180                 185                 190         


Thr Glu Arg Leu Leu Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu 
        195                 200                 205             


Asp Ile Thr Asp Asp Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser 
    210                 215                 220                 


Glu Asn Gly Ala Tyr Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys 
225                 230                 235                 240 


Leu Ile His Ala Ala Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly 
                245                 250                 255     


Glu Arg Asn Gln Ile Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys 
            260                 265                 270         


Glu Glu Leu Thr Glu His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser 
        275                 280                 285             


Leu Gln Ser Glu Asn Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln 
    290                 295                 300                 


Gln Lys Leu Lys Val Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys 
305                 310                 315                 320 


Leu His Arg Lys Leu Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu 
                325                 330                 335     


Glu Lys Leu Ser Lys Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu 
            340                 345                 350         


Leu Glu Thr Tyr Arg Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu 
        355                 360                 365             


Arg Thr Ile His Ser Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys 
    370                 375                 380                 


Ala His Asp Asn Trp Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn 
385                 390                 395                 400 


Asp Leu Arg Lys Glu Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr 
                405                 410                 415     


Glu Leu Lys Phe Glu Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val 
            420                 425                 430         


Pro Asn Thr Ala Phe Gly Arg Glu His Ser Pro Tyr Gly Pro Ser Pro 
        435                 440                 445             


Leu Gly Trp Pro Ser Ser Glu Thr Arg Ala Phe Leu Ser Pro Pro Thr 
    450                 455                 460                 


Leu Leu Glu Gly Pro Leu Arg Leu Ser Pro Leu Leu Pro Gly Gly Gly 
465                 470                 475                 480 


Gly Arg Gly Ser Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr 
                485                 490                 495     


Asn Glu Arg Gly Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg 
            500                 505                 510         


Ala Pro Ser Asp Thr Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg 
        515                 520                 525             


Arg Met Met Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu 
    530                 535                 540                 


Pro Pro Gln Arg Gln Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser 
545                 550                 555                 560 


Gly Pro Ala Glu Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met 
                565                 570                 575     


Asp Gly Ser Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys 
            580                 585                 590         


Asp Asp Leu Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu 
        595                 600                 605             


Asn Glu Ala Thr Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile 
    610                 615                 620                 


Arg Gly Pro Leu Phe Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg 
625                 630                 635                 640 


Gly Pro Pro Phe Pro Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser 
                645                 650                 655     


Arg Asp Tyr Phe Pro Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro 
            660                 665                 670         


Phe Ala Met Arg Asn Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu 
        675                 680                 685             


Pro Pro Arg Pro Gly Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg 
    690                 695                 700                 


Ser Glu Phe Pro Ser Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr 
705                 710                 715                 720 


Glu His Pro Glu Pro Gln Gln Glu Thr 
                725                 


<210>  87
<211>  3605
<212>  DNA
<213>  Homosapiens

<400>  87
gagtgcagga tatattagaa tctgaaatct ttctcaagga tatgaggtgc ctggtagaac     60

tttatttaca tgttaggaaa ttttaacatg agcttttcaa gaaatggaat tgaaaagtcc    120

agaggaagag gttgtggcag cactgcctga aggtatgaga ccagattcta atctttatgg    180

ttttccatgg gaattggtga tatgtgcagc tgttgttgga ttttttgctg ttctcttttt    240

tttgtggaga agttttagat cggttaggag tcggctttat gtgggacgag agaaaaagct    300

tgctctaatg ctttctggac taattgaaga aaaaagtaaa ctacttgaaa aatttagcct    360

tgttcaaaaa gagtatgaag gctatgaagt agagtcatct ttaaaggatg ccagctttga    420

gaaggaggca acagaagcac aaagtttgga ggcaacctgt gaaaagctga acaggtccaa    480

ttctgaactt gaggatgaaa tactctgtct agaaaaagag ttaaaagaag agaaatccaa    540

acattctgaa caagatgaat tgatggcgga tatttcaaaa aggatacagt ctctagaaga    600

tgagtcaaaa tccctcaaat cacaagtagc tgaagccaaa atgaccttca agatatttca    660

aatgaatgaa gaacgactga agatagcaat aaaagatgct ttgaatgaaa attctcaact    720

tcaggaaagc cagaaacagc ttttgcaaga agctgaagta tggaaagaac aagtgagtga    780

acttaataaa cagaaagtaa catttgaaga ctccaaagta catgcagaac aagttctaaa    840

tgataaagaa agtcacatca agactctgac tgaacgcttg ttaaagatga aagattgggc    900

tgctatgctt ggagaagaca taacggatga tgataacttg gaattagaaa tgaacagtga    960

atcggaaaat ggtgcttact tagataatcc tccaaaagga gctttgaaga aactgattca   1020

tgctgctaag ttaaatgctt ctttaaaaac cttagaagga gaaagaaacc aaatttatat   1080

tcagttgtct gaagttgata aaacaaagga agagcttaca gagcatatta aaaatcttca   1140

gactgaacaa gcatctttgc agtcagaaaa cacacatttt gaaaatgaga atcagaagct   1200

tcaacagaaa cttaaagtaa tgactgaatt atatcaagaa aatgaaatga aactccacag   1260

gaaattaaca gtagaggaaa attatcggtt agagaaagaa gagaaacttt ctaaagtaga   1320

tgaaaagatc agccatgcca ctgaagagct ggagacctat agaaagcgag ccaaagatct   1380

tgaagaagaa ttggagagaa ctattcattc ttatcaaggg cagattattt cccatgagaa   1440

aaaagcacat gataattggt tggcagctcg gaatgctgaa agaaacctca atgatttaag   1500

gaaagaaaat gctcacaaca gacaaaaatt aactgaaaca gagcttaaat ttgaactttt   1560

agaaaaagat ccttatgcac tcgatgttcc aaatacagca tttggcagag agcattcccc   1620

atatggtccc tcaccattgg gttggccttc atctgaaaca agagcttttc tctctcctcc   1680

aactttgttg gagggtccac tcagactctc acctttgctt ccagggggag gaggaagagg   1740

ctcacgaggc ccagggaatc ctctggacca tcagattacc aatgaaagag gagaatcaag   1800

ctgtgatagg ttaaccgatc ctcatagggc tccctctgac actgggtctc tgtcacctcc   1860

atgggaccag gaccgtagga tgatgtttcc tccgccagga caatcatatc ctgattcagc   1920

ccttcctcca caaaggcaag acagattttg ttctaattct ggtagactgt ctggaccagc   1980

agaactcaga agttttaata tgccttcttt ggataaaatg gatgggtcaa tgccttcaga   2040

aatggaatcc agtagaaatg ataccaaaga tgatcttggt aatttaaatg tgcctgattc   2100

atctctccct gctgaaaatg aagccactgg ccctggcttt gttcctccac ctcttgctcc   2160

aatcagaggt ccattgtttc cagtggatgc aagaggccca ttcttgagaa gaggacctcc   2220

tttcccccca cctcctccag gagccatgtt tggagcttct cgagattatt ttccaccagg   2280

ggatttccca ggtccaccac ctgctccatt tgcaatgaga aatgtctatc caccgagggg   2340

ttttcctcct taccttcccc caagacctgg atttttcccc ccacccccac attctgaagg   2400

tagaagtgag ttcccctcag gtttgattcc accttcaaat gagcctgcta ctgaacatcc   2460

agaaccacag caagaaacct gacaatattt ttgctctctt caaaagtaat tttgactgat   2520

ctcattttca gtttaagtaa ctgctgttac ttaagtgatt acacttttgc tcaaattgaa   2580

gcttaatgga attataattc tcaggatagt attttgtaaa taaagatgat ttaaatatga   2640

atcttatgag taaattattt caattttatt ttagacggta taactatttc aatttgatta   2700

atccactatt atataaacaa tagtgggagt tttatatatg taatctttca ggtggggagg   2760

ctttaaattc tgaagtctgt gtctttatgc caagaactgt atttactgtg gttgtggaca   2820

aatgtgaaag taactttatg cttaaataaa ttatagttga tttaaagatt tgtttggcat   2880

tgataataat aaaatcagta gtttttctat aactatggct ctattaactt ttttcctttt   2940

accaataact ttgaggtgca aaactcaaac ttatgtgggt cttttgtgtt caattatgtt   3000

atgacaaatg tgctctcttt cttgtaaata gacatgagtg gcccaaagca acaaattaat   3060

acacttttaa aagtcaaaat tgattatatt ttaaagataa ccaggatatt atctaatggt   3120

gaattgtaga attttgatct tcttattcac tgagtttctt gcacggtttc tttattgctt   3180

ttttttcccc gcctgttctt ttgtaaggta tttactattt tctgtggagg atattgagat   3240

gtactacagg ataactgtag tgaatgatgt gtcatcattt tgagctttgg actcaatatc   3300

tttagtgttt ccctaaatca gatttgtagg tcatgttaag cttcttgcac attaatatga   3360

ttatggaagg aaaggcagtg aagcataact aataaacatc ataatactta acgttgccca   3420

gttggttgtt ttagtattag actttttttt caatgccaaa agatagaaga ttaaatattc   3480

ttgaataaag cagtgatata tattggaaca cttcacccca gcatttcccc aggtgttgtt   3540

tggaacactg atcttgtgaa gtatttttgc tccctttcta ttctaaccct cacctcaaaa   3600

aaaaa                                                               3605


<210>  88
<211>  792
<212>  PRT
<213>  Homosapiens

<400>  88

Met Glu Leu Lys Ser Pro Glu Glu Glu Val Val Ala Ala Leu Pro Glu 
1               5                   10                  15      


Gly Met Arg Pro Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val 
            20                  25                  30          


Ile Cys Ala Ala Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp 
        35                  40                  45              


Arg Ser Phe Arg Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys 
    50                  55                  60                  


Lys Leu Ala Leu Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu 
65                  70                  75                  80  


Leu Glu Lys Phe Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val 
                85                  90                  95      


Glu Ser Ser Leu Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala 
            100                 105                 110         


Gln Ser Leu Glu Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu 
        115                 120                 125             


Leu Glu Asp Glu Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys 
    130                 135                 140                 


Ser Lys His Ser Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Arg 
145                 150                 155                 160 


Ile Gln Ser Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala 
                165                 170                 175     


Glu Ala Lys Met Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg Leu 
            180                 185                 190         


Lys Ile Ala Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Glu 
        195                 200                 205             


Ser Gln Lys Gln Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val 
    210                 215                 220                 


Ser Glu Leu Asn Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val His 
225                 230                 235                 240 


Ala Glu Gln Val Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu Thr 
                245                 250                 255     


Glu Arg Leu Leu Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu Asp 
            260                 265                 270         


Ile Thr Asp Asp Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu 
        275                 280                 285             


Asn Gly Ala Tyr Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu 
    290                 295                 300                 


Ile His Ala Ala Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu 
305                 310                 315                 320 


Arg Asn Gln Ile Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu 
                325                 330                 335     


Glu Leu Thr Glu His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu 
            340                 345                 350         


Gln Ser Glu Asn Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln Gln 
        355                 360                 365             


Lys Leu Lys Val Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu 
    370                 375                 380                 


His Arg Lys Leu Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu Glu 
385                 390                 395                 400 


Lys Leu Ser Lys Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu Leu 
                405                 410                 415     


Glu Thr Tyr Arg Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg 
            420                 425                 430         


Thr Ile His Ser Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys Ala 
        435                 440                 445             


His Asp Asn Trp Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn Asp 
    450                 455                 460                 


Leu Arg Lys Glu Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr Glu 
465                 470                 475                 480 


Leu Lys Phe Glu Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val Pro 
                485                 490                 495     


Asn Thr Ala Phe Gly Arg Glu His Ser Pro Tyr Gly Pro Ser Pro Leu 
            500                 505                 510         


Gly Trp Pro Ser Ser Glu Thr Arg Ala Phe Leu Ser Pro Pro Thr Leu 
        515                 520                 525             


Leu Glu Gly Pro Leu Arg Leu Ser Pro Leu Leu Pro Gly Gly Gly Gly 
    530                 535                 540                 


Arg Gly Ser Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn 
545                 550                 555                 560 


Glu Arg Gly Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala 
                565                 570                 575     


Pro Ser Asp Thr Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg Arg 
            580                 585                 590         


Met Met Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro 
        595                 600                 605             


Pro Gln Arg Gln Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser Gly 
    610                 615                 620                 


Pro Ala Glu Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met Asp 
625                 630                 635                 640 


Gly Ser Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys Asp 
                645                 650                 655     


Asp Leu Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn 
            660                 665                 670         


Glu Ala Thr Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile Arg 
        675                 680                 685             


Gly Pro Leu Phe Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg Gly 
    690                 695                 700                 


Pro Pro Phe Pro Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser Arg 
705                 710                 715                 720 


Asp Tyr Phe Pro Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro Phe 
                725                 730                 735     


Ala Met Arg Asn Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu Pro 
            740                 745                 750         


Pro Arg Pro Gly Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg Ser 
        755                 760                 765             


Glu Phe Pro Ser Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr Glu 
    770                 775                 780                 


His Pro Glu Pro Gln Gln Glu Thr 
785                 790         


<210>  89
<211>  3742
<212>  DNA
<213>  Homosapiens

<400>  89
gccgaccggc gcagggaggg ctgccttttc cttacagtac gccttgaggc ttccgggccg     60

ctgaagttta cgagcgaggg cagtgcagtt actcagtgtg ccggcctcgg acgcacgtga    120

gtagagtttg agaagacaga ggctggctcc cggcaggcca cgcccgcaga ggcctttccc    180

cctctccaca acttgtgttc tacttggttc cgccgagacc cacgacggtt ccgccccctt    240

cttcctagtc attgatgttg ttgttcttgt cagtgccgca gccccgaccg ccgggagctc    300

gaacccgagc cggggccgcc cgggtggcgc ggtggcggcg gctgcggctg cagcagctgc    360

gacggctgcg ggggctgctc cgggtactgc gggggcggcc gggagccggc agccggcggc    420

ggggccggat ggctctgtgc gggcaggcgg cgggcgctgc gtcgctgccc agcgagctga    480

tcgtgcacat cttctctttt ctgccggcgc ccgaccggct gcgggcctcg gcctcctgct    540

cgcactggcg tgagtgcctc ttctatccgg ccctgtggcc ccagctccgc atctgcctcc    600

gcgtctcgcc cgcggagcag cctcggctgg aattcctcat gcgcaagtgc ggctggttcg    660

tgcgagagct gcgtgttgaa ttcgccgccg agaactatct gagcggcggt ggcccagggg    720

acggaggtgg cgcggacacc gggactggag gggaggaagt cgaggccctg cagctctcag    780

ctcgttggct ggaagtgctg cgcacctact tggagctggt gctttgcgtg ctggtcagca    840

tccggaacaa caggaacctt cagaagttta gtctttttgg agacataagt gttctacaac    900

agcaaggaag tttgtcaaat acatacctca gcaaggtgga ccctgatggc aaaaaaatta    960

aacaaattca gcaactgttt gaagaaatcc tgagtaatag taggcaactg aaatggctgt   1020

cctgtgggtt tatgctggaa atagtaaccc caacatcact gtcatctctc tctaatgctg   1080

ttgccaacac catggagcac ctcagtttac tggacaataa tattcctggt aacagcactc   1140

ttattactgc agttgaactg gagcgatttg tgaatctgca ctcacttgcc ttggattttt   1200

gtgactttac agctgagatg gcaagagtct taactgatag caaccatgtg cctttgcaac   1260

gactgtctct tctggttcac aatgtttctg taatgcacaa gtctctggac aacatgccaa   1320

atgatgagca ttggaaagcc ctgtcacgaa agagcaccag ctttcgggtc tatataatgg   1380

cttttgatat caagagtgaa gatatgttaa agattctgaa acccagtata ccactagaga   1440

ggattcattt tgatagctat atcacttgtg tttcaggggc tattgttgat cttatatcca   1500

ggcaatatga caagttcctc actcatttta ttttaatgaa tgatgtgatt gacacatctg   1560

gttttccaga tcttagtgac aaccgaaatg aagatccgtt ggttttatta gcatggaggt   1620

gcacaaagct ctctcttctg gcaattcatg gttacacggt gtgggcacac aacctcattg   1680

ccattgctcg tcttcggggc tctgatctga aagtgcttga agtcaccgaa gaaagcattg   1740

attttgacca aggtgaactg gccgaccagg atgtagatcc agtgcataac cttattgagc   1800

aggtatccct gggcctgggt caaccttggc atgcagtcat ggacatcgaa tcactcagtg   1860

tcttcactga accaaatcgt catttttaca gagagatgca aagcttcagt gaagacattt   1920

agcttttttt taatgtagaa ttcctgtggt tacatatgca agtagggtcc tattatgttt   1980

tttttttcag tagtgtgaat taatcctttt gtgctgtgtt taatcagtat tagctttata   2040

gaattatata tgtatattct acttcttgat caaagaacgt agtcgggtat tggtttagaa   2100

gttcaaagtg acaatgtata gggctttcac ggttaatgga cttgttacca aaccttaagg   2160

atatacagcc gaagattgtc tgaggttgct ggctaacttt atttttcact gagttactct   2220

gcctttttga cgtttttatt ctttgtgtgt cagagttcag agctcaggag ccaaaatatt   2280

tttatacata tatagatata tatccatagc ctggtagatt tatatgcaat gcactgcatc   2340

catgcattct gatagcattt cattaatttt gatttcaaat ggaagataaa taatatccca   2400

aatgaattat ctgtaacaga aaagccaaga ctttaacttt cattacatat ctaatagttg   2460

atatcaccag ttaccatttt gaattttgta tagtactagg ttagaacatt gcttaatcct   2520

tttaaaaaaa atgcatttac gtaaacacga atactgaaat tgttggattt tttaactata   2580

tctgacataa ttttattcat caattacatt acacattcat ttagcccaga tttcaaatag   2640

tgggggaaga aagaaactgt atttcagagt aaaatctcct aaaggaaata aaaacacaga   2700

gttgtaaata cacatgcttg caaaaacatt agtcgtgaaa tccctagcaa caagtcactg   2760

gatttttctc tgtcagcacg cgtgtcagct gccaaagaat agacttaatg aagaagtgcc   2820

cacatgctgg caggggccgg cccactctgg ccagccagat actgctagat tgtaatattt   2880

aaggtcgaat ttcgacctgt ggtacacagc tgtgctgtgg ctcagtcagc aacctcagaa   2940

ctctgaaaaa acaaaacaaa aaaaaaaaaa aaagaaaaaa aaaacatgca cctgtttcac   3000

tgtgaatagt gaatgtaaag gaaagaaagg aaaaactgaa agcttgttct atcacaggta   3060

tgagctgcta tgatacatga agaacattcc atgaagtatg ttttaaaacc ttgttatatc   3120

tgagaggctt taaaagccta ttaactgttt cagggcaacc gcggtacaga cgtggtctct   3180

gtgagacttc cacctgaccc cagttttaag tggtacgaat gttgtgcatt taatgttaaa   3240

ggacagtctg caataataaa gtaagtagcc aacctgggtg cccagcagtg ctgagacctg   3300

gctgctctat tgtaagcttt ggaaacacaa tttatgcaac agatgtccag atatgattct   3360

atttatggaa aaaagtttat atgtgtttta caaatggttt taccatctta tattaaaatg   3420

accttttgac aggtgtgcac tgttttgtct ccagtgagca cataccatgc ggattttata   3480

tgtacatcag tagtgtgaat ccactggcac agtgtgtgta aatgccagat gtggtgagat   3540

tttatcttat aaatgtgatc agataaaata actcctgaca gaaactgtaa ggaaaccagc   3600

tgaatgtttg acctgatgac tgatgttgta tggtttatgt taaatgtata ttcttttaat   3660

caatgaataa agcattaaaa atgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3720

aaaaaaaaaa aaaaaaaaaa aa                                            3742


<210>  90
<211>  555
<212>  PRT
<213>  Homosapiens

<400>  90

Met Leu Leu Phe Leu Ser Val Pro Gln Pro Arg Pro Pro Gly Ala Arg 
1               5                   10                  15      


Thr Arg Ala Gly Ala Ala Arg Val Ala Arg Trp Arg Arg Leu Arg Leu 
            20                  25                  30          


Gln Gln Leu Arg Arg Leu Arg Gly Leu Leu Arg Val Leu Arg Gly Arg 
        35                  40                  45              


Pro Gly Ala Gly Ser Arg Arg Arg Gly Arg Met Ala Leu Cys Gly Gln 
    50                  55                  60                  


Ala Ala Gly Ala Ala Ser Leu Pro Ser Glu Leu Ile Val His Ile Phe 
65                  70                  75                  80  


Ser Phe Leu Pro Ala Pro Asp Arg Leu Arg Ala Ser Ala Ser Cys Ser 
                85                  90                  95      


His Trp Arg Glu Cys Leu Phe Tyr Pro Ala Leu Trp Pro Gln Leu Arg 
            100                 105                 110         


Ile Cys Leu Arg Val Ser Pro Ala Glu Gln Pro Arg Leu Glu Phe Leu 
        115                 120                 125             


Met Arg Lys Cys Gly Trp Phe Val Arg Glu Leu Arg Val Glu Phe Ala 
    130                 135                 140                 


Ala Glu Asn Tyr Leu Ser Gly Gly Gly Pro Gly Asp Gly Gly Gly Ala 
145                 150                 155                 160 


Asp Thr Gly Thr Gly Gly Glu Glu Val Glu Ala Leu Gln Leu Ser Ala 
                165                 170                 175     


Arg Trp Leu Glu Val Leu Arg Thr Tyr Leu Glu Leu Val Leu Cys Val 
            180                 185                 190         


Leu Val Ser Ile Arg Asn Asn Arg Asn Leu Gln Lys Phe Ser Leu Phe 
        195                 200                 205             


Gly Asp Ile Ser Val Leu Gln Gln Gln Gly Ser Leu Ser Asn Thr Tyr 
    210                 215                 220                 


Leu Ser Lys Val Asp Pro Asp Gly Lys Lys Ile Lys Gln Ile Gln Gln 
225                 230                 235                 240 


Leu Phe Glu Glu Ile Leu Ser Asn Ser Arg Gln Leu Lys Trp Leu Ser 
                245                 250                 255     


Cys Gly Phe Met Leu Glu Ile Val Thr Pro Thr Ser Leu Ser Ser Leu 
            260                 265                 270         


Ser Asn Ala Val Ala Asn Thr Met Glu His Leu Ser Leu Leu Asp Asn 
        275                 280                 285             


Asn Ile Pro Gly Asn Ser Thr Leu Ile Thr Ala Val Glu Leu Glu Arg 
    290                 295                 300                 


Phe Val Asn Leu His Ser Leu Ala Leu Asp Phe Cys Asp Phe Thr Ala 
305                 310                 315                 320 


Glu Met Ala Arg Val Leu Thr Asp Ser Asn His Val Pro Leu Gln Arg 
                325                 330                 335     


Leu Ser Leu Leu Val His Asn Val Ser Val Met His Lys Ser Leu Asp 
            340                 345                 350         


Asn Met Pro Asn Asp Glu His Trp Lys Ala Leu Ser Arg Lys Ser Thr 
        355                 360                 365             


Ser Phe Arg Val Tyr Ile Met Ala Phe Asp Ile Lys Ser Glu Asp Met 
    370                 375                 380                 


Leu Lys Ile Leu Lys Pro Ser Ile Pro Leu Glu Arg Ile His Phe Asp 
385                 390                 395                 400 


Ser Tyr Ile Thr Cys Val Ser Gly Ala Ile Val Asp Leu Ile Ser Arg 
                405                 410                 415     


Gln Tyr Asp Lys Phe Leu Thr His Phe Ile Leu Met Asn Asp Val Ile 
            420                 425                 430         


Asp Thr Ser Gly Phe Pro Asp Leu Ser Asp Asn Arg Asn Glu Asp Pro 
        435                 440                 445             


Leu Val Leu Leu Ala Trp Arg Cys Thr Lys Leu Ser Leu Leu Ala Ile 
    450                 455                 460                 


His Gly Tyr Thr Val Trp Ala His Asn Leu Ile Ala Ile Ala Arg Leu 
465                 470                 475                 480 


Arg Gly Ser Asp Leu Lys Val Leu Glu Val Thr Glu Glu Ser Ile Asp 
                485                 490                 495     


Phe Asp Gln Gly Glu Leu Ala Asp Gln Asp Val Asp Pro Val His Asn 
            500                 505                 510         


Leu Ile Glu Gln Val Ser Leu Gly Leu Gly Gln Pro Trp His Ala Val 
        515                 520                 525             


Met Asp Ile Glu Ser Leu Ser Val Phe Thr Glu Pro Asn Arg His Phe 
    530                 535                 540                 


Tyr Arg Glu Met Gln Ser Phe Ser Glu Asp Ile 
545                 550                 555 


<210>  91
<211>  466
<212>  DNA
<213>  Homosapiens

<400>  91
ggcaaagaga agggagcatg aagctgtcat tttgaacatg cctagtccca gagatgcatg     60

cggggagaac tctatgtgaa ggtgaaggca gagatgcttc attaagccaa ggaatgccaa    120

aggtggccag caaaccacca gaaaccaggc aagatgcatg gaacagattc tgtctcgtag    180

ctctcagaag gaaccaaccc tgccatcgca cattgatttt ggacttctgg cttccagaac    240

tgtgtgggtt tgtcatccag cgaggagatg aggagaaagt gctgggccac tccactggag    300

aaattggaga cctttcttct ggctgtgtct agggagccaa gagagtgaga gaaaactctt    360

tgaggaattg gctcagacag aggagggaga caaggtacca cgttaacaac aggactgaaa    420

tttcgcccag agtacagaga gctcagcaga ttcctggcat ttctga                   466


<210>  92
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  92

Met His Ala Gly Arg Thr Leu Cys Glu Gly Glu Gly Arg Asp Ala Ser 
1               5                   10                  15      


Leu Ser Gln Gly Met Pro Lys Val Ala Ser Lys Pro Pro Glu Thr Arg 
            20                  25                  30          


Gln Asp Ala Trp Asn Arg Phe Cys Leu Val Ala Leu Arg Arg Asn Gln 
        35                  40                  45              


Pro Cys His Arg Thr Leu Ile Leu Asp Phe Trp Leu Pro Glu Leu Cys 
    50                  55                  60                  


Gly Phe Val Ile Gln Arg Gly Asp Glu Glu Lys Val Leu Gly His Ser 
65                  70                  75                  80  


Thr Gly Glu Ile Gly Asp Leu Ser Ser Gly Cys Val 
                85                  90          


<210>  93
<211>  2751
<212>  DNA
<213>  Homosapiens

<400>  93
atggagtcag ggcagccggc tcgacggatt gccatggcgc cgctgctgga gtacgagcga     60

cagctggtgc tggaactgct cgacactgac gggctagtag tgtgcgcccg cgggctcggc    120

gcggaccggc tcctctacca ctttctccag ctgcactgcc acccagcctg cctggtgctg    180

gtgctcaaca cgcagccggc cgaggaggag tattttatca atcagctgaa gatagaagga    240

gttgaacacc tccctcgccg tgtaacaaat gaaatcacaa gcaacagtcg ctatgaagtt    300

tacacacaag gtggtgttat atttgcgaca agtaggatac ttgtggttga cttcttgact    360

gatagaatac cttcagattt aattactggc atcttggtgt atagagccca cagaataatc    420

gagtcttgtc aagaagcatt catcttgcgc ctctttcgcc agaaaaacaa acgtggtttt    480

attaaagctt tcacagacaa tgctgttgcc tttgatactg gtttttgtca tgtggaaaga    540

gtgatgagaa atctttttgt gaggaaactg tatctgtggc caaggttcca tgtagcagta    600

aactcatttt tagaacagca caaacctgaa gttgtagaaa tccatgtttc tatgacacct    660

accatgcttg ctatacagac tgctatactg gacattttaa atgcatgtct aaaggaacta    720

aaatgccata acccatcgct tgaagtggaa gatttatctt tagaaaatgc tattggaaaa    780

ccttttgaca agacaatccg ccattatctg gatcctttgt ggcaccagct tggagccaag    840

actaaatcct tagttcagga tttgaagata ttacgaactt tgctgcagta tctctctcag    900

tatgattgtg tcacatttct taatcttctg gaatctctga gagcaacgga aaaagctttt    960

ggtcagaatt caggttggct gtttcttgac tccagcacct cgatgtttat aaatgctcga   1020

gcaagggttt atcatcttcc agatgccaaa atgagtaaaa aagaaaaaat atctgaaaaa   1080

atggaaatta aagaagggga agaaacaaaa aaggaactgg tcctagaaag caacccaaag   1140

tgggaggcac tgactgaagt attaaaagaa attgaggcag aaaataagga gagtgaagct   1200

cttggtggtc caggtcaagt actgatttgt gcaagtgatg accgaacatg ttcccagctg   1260

agagactata tcactcttgg agcggaggcc ttcttattga ggctctacag gaaaaccttt   1320

gagaaggata gcaaagctga agaagtctgg atgaaattta ggaaggaaga cagttcaaag   1380

agaattagga aatctcacaa aagacctaaa gacccccaaa acaaagaacg ggcttctacc   1440

aaagaaagaa ccctcaaaaa gaaaaaacgg aagttgacct taactcaaat ggtaggaaaa   1500

cctgaagaac tggaagagga aggagatgtc gaggaaggat atcgtcgaga aataagcagt   1560

agcccagaaa gctgcccgga agaaattaag catgaagaat ttgatgtaaa tttgtcatcg   1620

gatgctgctt tcggaatcct gaaagaaccc ctcactatca tccatccgct tctgggttgc   1680

agcgacccct atgctctgac aagggtacta catgaagtgg agccaagata cgtggttctt   1740

tatgacgcag agctaacctt tgttcggcag cttgaaattt acagggcgag taggcctggg   1800

aaacctctga gggtttactt tcttatatac ggaggttcaa ctgaggaaca acgctatctc   1860

actgctttgc ggaaagaaaa ggaagctttt gaaaaactca taagggaaaa agcaagcatg   1920

gttgtccctg aagaaagaga aggcagagat gaaacaaact tagacctagt aagaggcaca   1980

gcatctgcag atgtttccac tgacactcgg aaagccggtg gccaggaaca gaatggtaca   2040

cagcaaagca tagttgtgga tatgcgtgaa tttcgaagtg agcttccatc tctgatccat   2100

cgtcggggca ttgacattga acccgtgact ttagaggttg gagattacat cctcactcca   2160

gaaatgtgcg tggagcgcaa gagtatcagt gatttaatcg gctctttaaa taacggccgc   2220

ctctacagcc agtgcatctc catgtcccgc tactacaagc gtcccgtgct tctgattgag   2280

tttgacccta gcaagccttt ctctctcact tcccgaggtg ccttgtttca ggagatctcc   2340

agcaatgaca ttagttccaa actcactctt cttacacttc acttccccag actacggatt   2400

ctctggtgcc cctctcctca tgcaacggcg gagttgtttg aggagctgaa acaaagcaag   2460

ccacagcctg atgcggcgac agcactggcc attacagcag attctgaaac ccttcccgag   2520

tcagagaagt ataatcctgg tccccaagac ttcttgttaa aaatgccagg ggtgaatgcc   2580

aaaaactgcc gctccttgat gcaccacgtt aagaacatcg cagaattagc agccctgtca   2640

caagacgagc tcacgagtat tctggggaat gctgcaaatg ccaaacagct ttatgatttc   2700

attcacacct cttttgcaga agtcgtatca aaaggaaaag ggaaaaagtg a            2751


<210>  94
<211>  916
<212>  PRT
<213>  Homosapiens

<400>  94

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu 
        355                 360                 365             


Thr Lys Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu 
    370                 375                 380                 


Thr Glu Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala 
385                 390                 395                 400 


Leu Gly Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr 
                405                 410                 415     


Cys Ser Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu 
            420                 425                 430         


Leu Arg Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu 
        435                 440                 445             


Val Trp Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys 
    450                 455                 460                 


Ser His Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Glu Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln 
                485                 490                 495     


Met Val Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu 
            500                 505                 510         


Gly Tyr Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu 
        515                 520                 525             


Ile Lys His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe 
    530                 535                 540                 


Gly Ile Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys 
545                 550                 555                 560 


Ser Asp Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg 
                565                 570                 575     


Tyr Val Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu 
            580                 585                 590         


Ile Tyr Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu 
        595                 600                 605             


Ile Tyr Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg 
    610                 615                 620                 


Lys Glu Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met 
625                 630                 635                 640 


Val Val Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu 
                645                 650                 655     


Val Arg Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala 
            660                 665                 670         


Gly Gly Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met 
        675                 680                 685             


Arg Glu Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile 
    690                 695                 700                 


Asp Ile Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro 
705                 710                 715                 720 


Glu Met Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu 
                725                 730                 735     


Asn Asn Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr 
            740                 745                 750         


Lys Arg Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser 
        755                 760                 765             


Leu Thr Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile 
    770                 775                 780                 


Ser Ser Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile 
785                 790                 795                 800 


Leu Trp Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu 
                805                 810                 815     


Lys Gln Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr 
            820                 825                 830         


Ala Asp Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro 
        835                 840                 845             


Gln Asp Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg 
    850                 855                 860                 


Ser Leu Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser 
865                 870                 875                 880 


Gln Asp Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln 
                885                 890                 895     


Leu Tyr Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly 
            900                 905                 910         


Lys Gly Lys Lys 
        915     


<210>  95
<211>  2393
<212>  DNA
<213>  Homosapiens

<400>  95
agtgcagctg agatgaataa tgaacttaat tttccataaa gacattctgt ttggcattcc     60

agctaataag gttccacaag atgaatggac agggtacacc ccacgaggta aagatgatga    120

aattccatgc cgaagaatgc ggagtggcag ttatatcaag gccatggggg atgaagacag    180

tggagactca gacacgagtc ctaagccttc tccaaaagtt gctgcgcgga gagaaagcta    240

tctcaaggct actcagccat cccttacaga actcaccaca ctcaaaatct ccaatgaaca    300

ctcacccaaa ctccagatcc ggagtcatag ttacctgagg gcagtgagtg aagtctccat    360

caaccggagc ctggacagcc tggaccctgc aggcttgctc acatcaccaa agttccgctc    420

caggaatgag agctacatgc gagccatgag caccatcagc caggtgagcg agatggaagt    480

gaacgggcag ttcgagtccg tgtgcgagtc cgtgttcagc gagctggagt cgcaggccgt    540

ggaagcgctg gacctgccca tgcccggctg cttccgcatg cggagccaca gctatgtgcg    600

ggccattgag aaaggctgct cccaggacga cgagtgcgtg tccctgaggt cgtcctcgcc    660

gccgcgcacc accaccaccg ttaggaccat ccagagcagc acggtgtcat cttgcattac    720

aacatataag aagacaccac ctccagtccc acccagaact accacgaaac ctttcatttc    780

tatcacagcc cagagtagca cagagtcagc ccaggatgcc tacatggacg gacagggcca    840

gcgaggagat attatcagcc agtctggact cagcaactcc accgagagcc tggacagtat    900

gaaggctctg acagccgcca tcgaagctgc aaacgcccag atccatggcc ctgccagtca    960

acacatgggc aataacactg ccactgtcac caccacgact accatagcca ccgtcaccac   1020

ggaggacagg aagaaggacc actttaagaa aaatcgatgc ctgtctatcg ggatacaggt   1080

ggatgatgct gaagaacctg acaaaacagg ggagaataaa gcacccagta agttccagtc   1140

cgtgggagtg caagtagaag aagagaagtg cttccgcagg ttcactcgat ccaacagtgt   1200

gacgacagca gtacaggccg acctggactt ccatgataat ctggaaaatt ctctggaatc   1260

tatagaggac aattcgtgtc ctggccccat ggccagacag ttctcccgcg atgccagcac   1320

ctccacagtc agcattcagg gctcaggaaa ccattaccat gcctgtgccg ccgatgatga   1380

ctttgacacg gattttgacc cctctattct gcctcctccg gacccctgga ttgactctat   1440

cactgaagac cctctggagg ccgtgcaaag gtcagtgtgc caccgggatg gccactggtt   1500

cctgaagctt ctccaggcag agcgagaccg catggagggg tggtgtcaac agatggagcg   1560

ggaagaacgg gaaaacaacc tgcccgaaga cattctagga aaaatccgaa ccgcagtggg   1620

cagtgcccaa cttctcatgg cccagaaatt ctaccagttc agagaactgt gtgaagaaaa   1680

cctgaatcct aatgctcatc caagacccac ctcccaggat ttggcggggt tttgggacat   1740

gctgcagttg tccatagaaa atattagtat gaaatttgat gaacttcatc agttaaaggc   1800

caataattgg aaacagatgg atcctcttga caagaaggag agaagggccc ctcctccagt   1860

gccaaagaag ccggcgaagg gccccgcgcc gctgatccgg gagcgctcgc tggagagctc   1920

gcagcgccag gaggcccgca agcgcctgat ggccgccaag cgcgccgcgt ccgtccgcca   1980

gaactcggcc accgagagcg ccgagagcat cgagatctac atccccgagg cgcagacccg   2040

gctctgagcg ccccgcagcc cggccgccgc cgccaagcat ctgtcccctc ctcccccggc   2100

cgctcctctg ccggctgcct ctccccctcc gagcccgtcc gctcccgagc tcggtgactt   2160

ccactgtcgc ggtgtagttg tccacctcgc aggagccgcc ccccgggccc ccctcagccc   2220

cccacttccc gtacccgttt gcccatctcc ttcttcaccg agcttcgccc cctgtcctga   2280

tgccgtcgcc ctgcctcata ctgagatcca accctttatt ttctgggcaa agccaaaccc   2340

acctgtgtag aagtgatgcc tttaggtcac ccgccgtcct cagttctctc gag          2393


<210>  96
<211>  675
<212>  PRT
<213>  Homosapiens

<400>  96

Met Asn Leu Ile Phe His Lys Asp Ile Leu Phe Gly Ile Pro Ala Asn 
1               5                   10                  15      


Lys Val Pro Gln Asp Glu Trp Thr Gly Tyr Thr Pro Arg Gly Lys Asp 
            20                  25                  30          


Asp Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala 
        35                  40                  45              


Met Gly Asp Glu Asp Ser Gly Asp Ser Asp Thr Ser Pro Lys Pro Ser 
    50                  55                  60                  


Pro Lys Val Ala Ala Arg Arg Glu Ser Tyr Leu Lys Ala Thr Gln Pro 
65                  70                  75                  80  


Ser Leu Thr Glu Leu Thr Thr Leu Lys Ile Ser Asn Glu His Ser Pro 
                85                  90                  95      


Lys Leu Gln Ile Arg Ser His Ser Tyr Leu Arg Ala Val Ser Glu Val 
            100                 105                 110         


Ser Ile Asn Arg Ser Leu Asp Ser Leu Asp Pro Ala Gly Leu Leu Thr 
        115                 120                 125             


Ser Pro Lys Phe Arg Ser Arg Asn Glu Ser Tyr Met Arg Ala Met Ser 
    130                 135                 140                 


Thr Ile Ser Gln Val Ser Glu Met Glu Val Asn Gly Gln Phe Glu Ser 
145                 150                 155                 160 


Val Cys Glu Ser Val Phe Ser Glu Leu Glu Ser Gln Ala Val Glu Ala 
                165                 170                 175     


Leu Asp Leu Pro Met Pro Gly Cys Phe Arg Met Arg Ser His Ser Tyr 
            180                 185                 190         


Val Arg Ala Ile Glu Lys Gly Cys Ser Gln Asp Asp Glu Cys Val Ser 
        195                 200                 205             


Leu Arg Ser Ser Ser Pro Pro Arg Thr Thr Thr Thr Val Arg Thr Ile 
    210                 215                 220                 


Gln Ser Ser Thr Val Ser Ser Cys Ile Thr Thr Tyr Lys Lys Thr Pro 
225                 230                 235                 240 


Pro Pro Val Pro Pro Arg Thr Thr Thr Lys Pro Phe Ile Ser Ile Thr 
                245                 250                 255     


Ala Gln Ser Ser Thr Glu Ser Ala Gln Asp Ala Tyr Met Asp Gly Gln 
            260                 265                 270         


Gly Gln Arg Gly Asp Ile Ile Ser Gln Ser Gly Leu Ser Asn Ser Thr 
        275                 280                 285             


Glu Ser Leu Asp Ser Met Lys Ala Leu Thr Ala Ala Ile Glu Ala Ala 
    290                 295                 300                 


Asn Ala Gln Ile His Gly Pro Ala Ser Gln His Met Gly Asn Asn Thr 
305                 310                 315                 320 


Ala Thr Val Thr Thr Thr Thr Thr Ile Ala Thr Val Thr Thr Glu Asp 
                325                 330                 335     


Arg Lys Lys Asp His Phe Lys Lys Asn Arg Cys Leu Ser Ile Gly Ile 
            340                 345                 350         


Gln Val Asp Asp Ala Glu Glu Pro Asp Lys Thr Gly Glu Asn Lys Ala 
        355                 360                 365             


Pro Ser Lys Phe Gln Ser Val Gly Val Gln Val Glu Glu Glu Lys Cys 
    370                 375                 380                 


Phe Arg Arg Phe Thr Arg Ser Asn Ser Val Thr Thr Ala Val Gln Ala 
385                 390                 395                 400 


Asp Leu Asp Phe His Asp Asn Leu Glu Asn Ser Leu Glu Ser Ile Glu 
                405                 410                 415     


Asp Asn Ser Cys Pro Gly Pro Met Ala Arg Gln Phe Ser Arg Asp Ala 
            420                 425                 430         


Ser Thr Ser Thr Val Ser Ile Gln Gly Ser Gly Asn His Tyr His Ala 
        435                 440                 445             


Cys Ala Ala Asp Asp Asp Phe Asp Thr Asp Phe Asp Pro Ser Ile Leu 
    450                 455                 460                 


Pro Pro Pro Asp Pro Trp Ile Asp Ser Ile Thr Glu Asp Pro Leu Glu 
465                 470                 475                 480 


Ala Val Gln Arg Ser Val Cys His Arg Asp Gly His Trp Phe Leu Lys 
                485                 490                 495     


Leu Leu Gln Ala Glu Arg Asp Arg Met Glu Gly Trp Cys Gln Gln Met 
            500                 505                 510         


Glu Arg Glu Glu Arg Glu Asn Asn Leu Pro Glu Asp Ile Leu Gly Lys 
        515                 520                 525             


Ile Arg Thr Ala Val Gly Ser Ala Gln Leu Leu Met Ala Gln Lys Phe 
    530                 535                 540                 


Tyr Gln Phe Arg Glu Leu Cys Glu Glu Asn Leu Asn Pro Asn Ala His 
545                 550                 555                 560 


Pro Arg Pro Thr Ser Gln Asp Leu Ala Gly Phe Trp Asp Met Leu Gln 
                565                 570                 575     


Leu Ser Ile Glu Asn Ile Ser Met Lys Phe Asp Glu Leu His Gln Leu 
            580                 585                 590         


Lys Ala Asn Asn Trp Lys Gln Met Asp Pro Leu Asp Lys Lys Glu Arg 
        595                 600                 605             


Arg Ala Pro Pro Pro Val Pro Lys Lys Pro Ala Lys Gly Pro Ala Pro 
    610                 615                 620                 


Leu Ile Arg Glu Arg Ser Leu Glu Ser Ser Gln Arg Gln Glu Ala Arg 
625                 630                 635                 640 


Lys Arg Leu Met Ala Ala Lys Arg Ala Ala Ser Val Arg Gln Asn Ser 
                645                 650                 655     


Ala Thr Glu Ser Ala Glu Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln 
            660                 665                 670         


Thr Arg Leu 
        675 


<210>  97
<211>  3347
<212>  DNA
<213>  Homosapiens

<400>  97
tgcccaagac gggtctggag cctgacttcc gggtgtccat gaccctggcg gctgcttccg     60

gtccgccatg aaagggctat caggcagccg cagccatcac cacggggtca cctgcgactc    120

ggcctgtgac tcgctgtcgc accactccga ccgcaagccc tacctgctga gcccagtgga    180

gcaccacccc gcagaccacc catactacac ccagcggaac tccttccagg ctgagtgcgt    240

gggccccttc agcgacccgc tggccagcag caccttcccc cgcaggcact acacctcgca    300

gcaagagctg aaggacgagt gtgccctggt gccccgcacc ctggccacca aggcgaaccg    360

catccccgcc aacctgctgg accagttcga gcggcagctg ccactcagcc gcgatggcta    420

tcacaccctg cagtacaagc gcacggccgt ggagcaccgc agcgacagcc ccggccgcat    480

ccgccacctg gtgcactcgg tccagaagct cttcaccaag tcgcactccc tggaggggcc    540

gtccaagggc agcgtcaacg ggggcaaggc cagccctgac gaggcgcagg cggcgcgcta    600

tggcaaacgc agcaagagca aggagcggcg cgcggagccc aaggcccggc ccagcacctc    660

cccgggctgg tggagctcgg acgacaacct ggatggtgac atgtgcatct accacgcccc    720

ctcgggcgtg atgaccatgg gcaggtgccc cgaccgctcg gcctcacagt acttcctgga    780

ggcctacaac accatcagcg agcaggcggt gaaggcctcc cggagcaaca acgacgtcaa    840

gtgctccacc tgcgccaacc tgccggtcag cctggacacc ccgctgctga agaagagcgc    900

ctggtcctcc acgctcaccg tgagccgggc ccgggaggtt taccagaagg cctcggtgaa    960

catggaccag gccatggtga agtccgagtc gtgtcagcaa gaacgctcct gccagtacct   1020

gcaggttcca caagatgaat ggacagggta caccccacga ggtaaagatg atgaaattcc   1080

atgccgaaga atgcggagtg gcagttatat caaggccatg ggggatgaag acagtggaga   1140

ctcagacacg agtcctaagc cttctccaaa agttgctgcg cggagagaaa gctatctcaa   1200

ggctactcag ccatccctta cagaactcac cacactcaaa atctccaatg aacactcacc   1260

caaactccag atccggagtc atagttacct gagggcagtg agtgaagtct ccatcaaccg   1320

gagcctggac agcctggacc ctgcaggctt gctcacatca ccaaagttcc gctccaggaa   1380

tgagagctac atgcgagcca tgagcaccat cagccaggtg agcgagatgg aagtgaacgg   1440

gcagttcgag tccgtgtgcg agtccgtgtt cagcgagctg gagtcgcagg ccgtggaagc   1500

gctggacctg cccatgcccg gctgcttccg catgcggagc cacagctatg tgcgggccat   1560

tgagaaaggc tgctcccagg acgacgagtg cgtgtccctg aggtcgtcct cgccgccgcg   1620

caccaccacc accgttagga ccatccagag cagcacggtg tcatcttgca ttacaacata   1680

taagaagaca ccacctccag tcccacccag aactaccacg aaacctttca tttctatcac   1740

agcccagagt agcacagagt cagcccagga tgcctacatg gacggacagg gccagcgagg   1800

agatattatc agccagtctg gactcagcaa ctccaccgag agcctggaca gtatgaaggc   1860

tctgacagcc gccatcgaag ctgcaaacgc ccagatccat ggccctgcca gtcaacacat   1920

gggcaataac actgccactg tcaccaccac gactaccata gccaccgtca ccacggagga   1980

caggaagaag gaccacttta agaaaaatcg atgcctgtct atcgggatac aggtggatga   2040

tgctgaagaa cctgacaaaa caggggagaa taaagcaccc agtaagttcc agtccgtggg   2100

agtgcaagta gaagaagaga agtgcttccg caggttcact cgatccaaca gtgtgacgac   2160

agcagtacag gccgacctgg acttccatga taatctggaa aattctctgg aatctataga   2220

ggacaattcg tgtcctggcc ccatggccag acagttctcc cgcgatgcca gcacctccac   2280

agtcagcatt cagggctcag gaaaccatta ccatgcctgt gccgccgatg atgactttga   2340

cacggatttt gacccctcta ttctgcctcc tccggacccc tggattgact ctatcactga   2400

agaccctctg gaggccgtgc aaaggtcagt gtgccaccgg gatggccact ggttcctgaa   2460

gcttctccag gcagagcgag accgcatgga ggggtggtgt caacagatgg agcgggaaga   2520

acgggaaaac aacctgcccg aagacattct aggaaaaatc cgaaccgcag tgggcagtgc   2580

ccaacttctc atggcccaga aattctacca gttcagagaa ctgtgtgaag aaaacctgaa   2640

tcctaatgct catccaagac ccacctccca ggatttggcg gggttttggg acatgctgca   2700

gttgtccata gaaaatatta gtatgaaatt tgatgaactt catcagttaa aggccaataa   2760

ttggaaacag atggatcctc ttgacaagaa ggagagaagg gcccctcctc cagtgccaaa   2820

gaagccggcg aagggccccg cgccgctgat ccgggagcgc tcgctggaga gctcgcagcg   2880

ccaggaggcc cgcaagcgcc tgatggccgc caagcgcgcc gcgtccgtcc gccagaactc   2940

ggccaccgag agcgccgaga gcatcgagat ctacatcccc gaggcgcaga cccggctctg   3000

agcgccccgc agcccggccg ccgccgccaa gcatctgtcc cctcctcccc cggccgctcc   3060

tctgccggct gcctctcccc ctccgagccc gtccgctccc gagctcggtg acttccactg   3120

tcgcggtgta gttgtccacc tcgcaggagc cgccccccgg gcccccctca gccccccact   3180

tcccgtaccc gtttgcccat ctccttcttc accgagcttc gccccctgtc ctgatgccgt   3240

cgccctgcct catactgaga tccaaccctt tattttctgg gcaaagccaa acccacctgt   3300

gtagaagtga tgcctttagg tcacccgccg tcctcagttc tctcgag                 3347


<210>  98
<211>  977
<212>  PRT
<213>  Homosapiens

<400>  98

Met Lys Gly Leu Ser Gly Ser Arg Ser His His His Gly Val Thr Cys 
1               5                   10                  15      


Asp Ser Ala Cys Asp Ser Leu Ser His His Ser Asp Arg Lys Pro Tyr 
            20                  25                  30          


Leu Leu Ser Pro Val Glu His His Pro Ala Asp His Pro Tyr Tyr Thr 
        35                  40                  45              


Gln Arg Asn Ser Phe Gln Ala Glu Cys Val Gly Pro Phe Ser Asp Pro 
    50                  55                  60                  


Leu Ala Ser Ser Thr Phe Pro Arg Arg His Tyr Thr Ser Gln Gln Glu 
65                  70                  75                  80  


Leu Lys Asp Glu Cys Ala Leu Val Pro Arg Thr Leu Ala Thr Lys Ala 
                85                  90                  95      


Asn Arg Ile Pro Ala Asn Leu Leu Asp Gln Phe Glu Arg Gln Leu Pro 
            100                 105                 110         


Leu Ser Arg Asp Gly Tyr His Thr Leu Gln Tyr Lys Arg Thr Ala Val 
        115                 120                 125             


Glu His Arg Ser Asp Ser Pro Gly Arg Ile Arg His Leu Val His Ser 
    130                 135                 140                 


Val Gln Lys Leu Phe Thr Lys Ser His Ser Leu Glu Gly Pro Ser Lys 
145                 150                 155                 160 


Gly Ser Val Asn Gly Gly Lys Ala Ser Pro Asp Glu Ala Gln Ala Ala 
                165                 170                 175     


Arg Tyr Gly Lys Arg Ser Lys Ser Lys Glu Arg Arg Ala Glu Pro Lys 
            180                 185                 190         


Ala Arg Pro Ser Thr Ser Pro Gly Trp Trp Ser Ser Asp Asp Asn Leu 
        195                 200                 205             


Asp Gly Asp Met Cys Ile Tyr His Ala Pro Ser Gly Val Met Thr Met 
    210                 215                 220                 


Gly Arg Cys Pro Asp Arg Ser Ala Ser Gln Tyr Phe Leu Glu Ala Tyr 
225                 230                 235                 240 


Asn Thr Ile Ser Glu Gln Ala Val Lys Ala Ser Arg Ser Asn Asn Asp 
                245                 250                 255     


Val Lys Cys Ser Thr Cys Ala Asn Leu Pro Val Ser Leu Asp Thr Pro 
            260                 265                 270         


Leu Leu Lys Lys Ser Ala Trp Ser Ser Thr Leu Thr Val Ser Arg Ala 
        275                 280                 285             


Arg Glu Val Tyr Gln Lys Ala Ser Val Asn Met Asp Gln Ala Met Val 
    290                 295                 300                 


Lys Ser Glu Ser Cys Gln Gln Glu Arg Ser Cys Gln Tyr Leu Gln Val 
305                 310                 315                 320 


Pro Gln Asp Glu Trp Thr Gly Tyr Thr Pro Arg Gly Lys Asp Asp Glu 
                325                 330                 335     


Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala Met Gly 
            340                 345                 350         


Asp Glu Asp Ser Gly Asp Ser Asp Thr Ser Pro Lys Pro Ser Pro Lys 
        355                 360                 365             


Val Ala Ala Arg Arg Glu Ser Tyr Leu Lys Ala Thr Gln Pro Ser Leu 
    370                 375                 380                 


Thr Glu Leu Thr Thr Leu Lys Ile Ser Asn Glu His Ser Pro Lys Leu 
385                 390                 395                 400 


Gln Ile Arg Ser His Ser Tyr Leu Arg Ala Val Ser Glu Val Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Asp Ser Leu Asp Pro Ala Gly Leu Leu Thr Ser Pro 
            420                 425                 430         


Lys Phe Arg Ser Arg Asn Glu Ser Tyr Met Arg Ala Met Ser Thr Ile 
        435                 440                 445             


Ser Gln Val Ser Glu Met Glu Val Asn Gly Gln Phe Glu Ser Val Cys 
    450                 455                 460                 


Glu Ser Val Phe Ser Glu Leu Glu Ser Gln Ala Val Glu Ala Leu Asp 
465                 470                 475                 480 


Leu Pro Met Pro Gly Cys Phe Arg Met Arg Ser His Ser Tyr Val Arg 
                485                 490                 495     


Ala Ile Glu Lys Gly Cys Ser Gln Asp Asp Glu Cys Val Ser Leu Arg 
            500                 505                 510         


Ser Ser Ser Pro Pro Arg Thr Thr Thr Thr Val Arg Thr Ile Gln Ser 
        515                 520                 525             


Ser Thr Val Ser Ser Cys Ile Thr Thr Tyr Lys Lys Thr Pro Pro Pro 
    530                 535                 540                 


Val Pro Pro Arg Thr Thr Thr Lys Pro Phe Ile Ser Ile Thr Ala Gln 
545                 550                 555                 560 


Ser Ser Thr Glu Ser Ala Gln Asp Ala Tyr Met Asp Gly Gln Gly Gln 
                565                 570                 575     


Arg Gly Asp Ile Ile Ser Gln Ser Gly Leu Ser Asn Ser Thr Glu Ser 
            580                 585                 590         


Leu Asp Ser Met Lys Ala Leu Thr Ala Ala Ile Glu Ala Ala Asn Ala 
        595                 600                 605             


Gln Ile His Gly Pro Ala Ser Gln His Met Gly Asn Asn Thr Ala Thr 
    610                 615                 620                 


Val Thr Thr Thr Thr Thr Ile Ala Thr Val Thr Thr Glu Asp Arg Lys 
625                 630                 635                 640 


Lys Asp His Phe Lys Lys Asn Arg Cys Leu Ser Ile Gly Ile Gln Val 
                645                 650                 655     


Asp Asp Ala Glu Glu Pro Asp Lys Thr Gly Glu Asn Lys Ala Pro Ser 
            660                 665                 670         


Lys Phe Gln Ser Val Gly Val Gln Val Glu Glu Glu Lys Cys Phe Arg 
        675                 680                 685             


Arg Phe Thr Arg Ser Asn Ser Val Thr Thr Ala Val Gln Ala Asp Leu 
    690                 695                 700                 


Asp Phe His Asp Asn Leu Glu Asn Ser Leu Glu Ser Ile Glu Asp Asn 
705                 710                 715                 720 


Ser Cys Pro Gly Pro Met Ala Arg Gln Phe Ser Arg Asp Ala Ser Thr 
                725                 730                 735     


Ser Thr Val Ser Ile Gln Gly Ser Gly Asn His Tyr His Ala Cys Ala 
            740                 745                 750         


Ala Asp Asp Asp Phe Asp Thr Asp Phe Asp Pro Ser Ile Leu Pro Pro 
        755                 760                 765             


Pro Asp Pro Trp Ile Asp Ser Ile Thr Glu Asp Pro Leu Glu Ala Val 
    770                 775                 780                 


Gln Arg Ser Val Cys His Arg Asp Gly His Trp Phe Leu Lys Leu Leu 
785                 790                 795                 800 


Gln Ala Glu Arg Asp Arg Met Glu Gly Trp Cys Gln Gln Met Glu Arg 
                805                 810                 815     


Glu Glu Arg Glu Asn Asn Leu Pro Glu Asp Ile Leu Gly Lys Ile Arg 
            820                 825                 830         


Thr Ala Val Gly Ser Ala Gln Leu Leu Met Ala Gln Lys Phe Tyr Gln 
        835                 840                 845             


Phe Arg Glu Leu Cys Glu Glu Asn Leu Asn Pro Asn Ala His Pro Arg 
    850                 855                 860                 


Pro Thr Ser Gln Asp Leu Ala Gly Phe Trp Asp Met Leu Gln Leu Ser 
865                 870                 875                 880 


Ile Glu Asn Ile Ser Met Lys Phe Asp Glu Leu His Gln Leu Lys Ala 
                885                 890                 895     


Asn Asn Trp Lys Gln Met Asp Pro Leu Asp Lys Lys Glu Arg Arg Ala 
            900                 905                 910         


Pro Pro Pro Val Pro Lys Lys Pro Ala Lys Gly Pro Ala Pro Leu Ile 
        915                 920                 925             


Arg Glu Arg Ser Leu Glu Ser Ser Gln Arg Gln Glu Ala Arg Lys Arg 
    930                 935                 940                 


Leu Met Ala Ala Lys Arg Ala Ala Ser Val Arg Gln Asn Ser Ala Thr 
945                 950                 955                 960 


Glu Ser Ala Glu Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln Thr Arg 
                965                 970                 975     


Leu 
    


<210>  99
<211>  3038
<212>  DNA
<213>  Homosapiens

<400>  99
tcaatcagaa agcccttttc attgcaggag aagaggacaa agatactcag agagaaaaag     60

taaaagaccg aagaaggagg ctggagagac caggatcctt ccagctgaac aaagtcagcc    120

acaaagcaga ctagccagcc ggctacaatt ggagtcagag tcccaaagac atgggcttgt    180

tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg gccactggat    240

tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc actggcacag    300

aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat ctcatcaatg    360

tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc ctttatgggg    420

ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc tttggcgact    480

acaagaccac catctgcggc aagggcctga gcgcaacggt aacagggggc cagaagggga    540

ggggttccag aggccaacat caagctcatt ctttggagcg ggtgtgtcat tgtttgggaa    600

aatggctagg acatcccgac aagtttgtgg gcatcaccta tgccctgacc gttgtgtggc    660

tcctggtgtt tgcctgctct gctgtgcctg tgtacattta cttcaacacc tggaccacct    720

gccagtctat tgccttcccc agcaagacct ctgccagtat aggcagtctc tgtgctgatg    780

ccagaatgta tggtgttctc ccatggaatg ctttccctgg caaggtttgt ggctccaacc    840

ttctgtccat ctgcaaaaca gctgagttcc aaatgacctt ccacctgttt attgctgcat    900

ttgtgggggc tgcagctaca ctggtttccc tgctcacctt catgattgct gccacttaca    960

actttgccgt ccttaaactc atgggccgag gcaccaagtt ctgatccccc gtagaaatcc   1020

ccctttctct aatagcgagg ctctaaccac acagcctaca atgctgcgtc tcccatctta   1080

actctttgcc tttgccacca actggccctc ttcttacttg atgagtgtaa caagaaagga   1140

gagtcttgca gtgattaagg tctctctttg gactctcccc tcttatgtac ctcttttagt   1200

cattttgctt catagctggt tcctgctaga aatgggaaat gcctaagaag atgacttccc   1260

aactgcaagt cacaaaggaa tggaggctct aattgaattt tcaagcatct cctgaggatc   1320

agaaagtaat ttcttctcaa agggtacttc cactgatgga aacaaagtgg aaggaaagat   1380

gctcaggtac agagaaggaa tgtctttggt cctcttgcca tctatagggg ccaaatatat   1440

tctctttggt gtacaaaatg gaattcattc tggtctctct attaccactg aagatagaag   1500

aaaaaagaat gtcagaaaaa caataagagc gtttgcccaa atctgcctat tgcagctggg   1560

agaagggggt caaagcaagg atctttcacc cacagaaaga gagcactgac cccgatggcg   1620

atggactact gaagccctaa ctcagccaac cttacttaca gcataaggga gcgtagaatc   1680

tgtgtagacg aagggggcat ctggccttac acctcgttag ggaagagaaa cagggtgttg   1740

tcagcatctt ctcactccct tctccttgat aacagctacc atgacaaccc tgtggtttcc   1800

aaggagctga gaatagaagg aaactagctt acatgagaac agactggcct gaggagcagc   1860

agttgctggt ggctaatggt gtaacctgag atggccctct ggtagacaca ggatagataa   1920

ctctttggat agcatgtctt tttttctgtt aattagttgt gtactctggc ctctgtcata   1980

tcttcacaat ggtgctcatt tcatgggggt attatccatt cagtcatcgt aggtgatttg   2040

aaggtcttga tttgttttag aatgatgcac atttcatgta ttccagtttg tttattactt   2100

atttggggtt gcatcagaaa tgtctggaga ataattcttt gattatgact gttttttaaa   2160

ctaggaaaat tggacattaa gcatcacaaa tgatattaaa aattggctag ttgaatctat   2220

tgggattttc tacaagtatt ctgcctttgc agaaacagat ttggtgaatt tgaatctcaa   2280

tttgagtaat ctgatcgttc tttctagcta atggaaaatg attttactta gcaatgttat   2340

cttggtgtgt taagagttag gtttaacata aaggttattt tctcctgata tagatcacat   2400

aacagaatgc accagtcatc agctattcag ttggtaagct tccaggaaaa aggacaggca   2460

gaaagagttt gagacctgaa tagctcccag atttcagtct tttcctgttt ttgttaactt   2520

tgggttaaaa aaaaaaaaag tctgattggt tttaattgaa ggaaagattt gtactacagt   2580

tcttttgttg taaagagttg tgttgttctt ttcccccaaa gtggtttcag caatatttaa   2640

ggagatgtaa gagctttaca aaaagacact tgatacttgt tttcaaacca gtatacaaga   2700

taagcttcca ggctgcatag aaggaggaga gggaaaatgt tttgtaagaa accaatcaag   2760

ataaaggaca gtgaagtaat ccgtaccttg tgttttgttt tgatttaata acataacaaa   2820

taaccaaccc ttccctgaaa acctcacatg catacataca catatataca cacacaaaga   2880

gagttaatca actgaaagtg tttccttcat ttctgatata gaattgcaat tttaacacac   2940

ataaaggata aacttttaga aacttatctt acaaagtgta ttttataaaa ttaaagaaaa   3000

taaaattaag aatgttctca atcaaaaaaa aaaaaaaa                           3038


<210>  100
<211>  277
<212>  PRT
<213>  Homosapiens

<400>  100

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  101
<211>  2933
<212>  DNA
<213>  Homosapiens

<400>  101
tcaatcagaa agcccttttc attgcaggag aagaggacaa agatactcag agagaaaaag     60

taaaagaccg aagaaggagg ctggagagac caggatcctt ccagctgaac aaagtcagcc    120

acaaagcaga ctagccagcc ggctacaatt ggagtcagag tcccaaagac atgggcttgt    180

tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg gccactggat    240

tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc actggcacag    300

aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat ctcatcaatg    360

tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc ctttatgggg    420

ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc tttggcgact    480

acaagaccac catctgcggc aagggcctga gcgcaacgtt tgtgggcatc acctatgccc    540

tgaccgttgt gtggctcctg gtgtttgcct gctctgctgt gcctgtgtac atttacttca    600

acacctggac cacctgccag tctattgcct tccccagcaa gacctctgcc agtataggca    660

gtctctgtgc tgatgccaga atgtatggtg ttctcccatg gaatgctttc cctggcaagg    720

tttgtggctc caaccttctg tccatctgca aaacagctga gttccaaatg accttccacc    780

tgtttattgc tgcatttgtg ggggctgcag ctacactggt ttccctgctc accttcatga    840

ttgctgccac ttacaacttt gccgtcctta aactcatggg ccgaggcacc aagttctgat    900

cccccgtaga aatccccctt tctctaatag cgaggctcta accacacagc ctacaatgct    960

gcgtctccca tcttaactct ttgcctttgc caccaactgg ccctcttctt acttgatgag   1020

tgtaacaaga aaggagagtc ttgcagtgat taaggtctct ctttggactc tcccctctta   1080

tgtacctctt ttagtcattt tgcttcatag ctggttcctg ctagaaatgg gaaatgccta   1140

agaagatgac ttcccaactg caagtcacaa aggaatggag gctctaattg aattttcaag   1200

catctcctga ggatcagaaa gtaatttctt ctcaaagggt acttccactg atggaaacaa   1260

agtggaagga aagatgctca ggtacagaga aggaatgtct ttggtcctct tgccatctat   1320

aggggccaaa tatattctct ttggtgtaca aaatggaatt cattctggtc tctctattac   1380

cactgaagat agaagaaaaa agaatgtcag aaaaacaata agagcgtttg cccaaatctg   1440

cctattgcag ctgggagaag ggggtcaaag caaggatctt tcacccacag aaagagagca   1500

ctgaccccga tggcgatgga ctactgaagc cctaactcag ccaaccttac ttacagcata   1560

agggagcgta gaatctgtgt agacgaaggg ggcatctggc cttacacctc gttagggaag   1620

agaaacaggg tgttgtcagc atcttctcac tcccttctcc ttgataacag ctaccatgac   1680

aaccctgtgg tttccaagga gctgagaata gaaggaaact agcttacatg agaacagact   1740

ggcctgagga gcagcagttg ctggtggcta atggtgtaac ctgagatggc cctctggtag   1800

acacaggata gataactctt tggatagcat gtcttttttt ctgttaatta gttgtgtact   1860

ctggcctctg tcatatcttc acaatggtgc tcatttcatg ggggtattat ccattcagtc   1920

atcgtaggtg atttgaaggt cttgatttgt tttagaatga tgcacatttc atgtattcca   1980

gtttgtttat tacttatttg gggttgcatc agaaatgtct ggagaataat tctttgatta   2040

tgactgtttt ttaaactagg aaaattggac attaagcatc acaaatgata ttaaaaattg   2100

gctagttgaa tctattggga ttttctacaa gtattctgcc tttgcagaaa cagatttggt   2160

gaatttgaat ctcaatttga gtaatctgat cgttctttct agctaatgga aaatgatttt   2220

acttagcaat gttatcttgg tgtgttaaga gttaggttta acataaaggt tattttctcc   2280

tgatatagat cacataacag aatgcaccag tcatcagcta ttcagttggt aagcttccag   2340

gaaaaaggac aggcagaaag agtttgagac ctgaatagct cccagatttc agtcttttcc   2400

tgtttttgtt aactttgggt taaaaaaaaa aaaagtctga ttggttttaa ttgaaggaaa   2460

gatttgtact acagttcttt tgttgtaaag agttgtgttg ttcttttccc ccaaagtggt   2520

ttcagcaata tttaaggaga tgtaagagct ttacaaaaag acacttgata cttgttttca   2580

aaccagtata caagataagc ttccaggctg catagaagga ggagagggaa aatgttttgt   2640

aagaaaccaa tcaagataaa ggacagtgaa gtaatccgta ccttgtgttt tgttttgatt   2700

taataacata acaaataacc aacccttccc tgaaaacctc acatgcatac atacacatat   2760

atacacacac aaagagagtt aatcaactga aagtgtttcc ttcatttctg atatagaatt   2820

gcaattttaa cacacataaa ggataaactt ttagaaactt atcttacaaa gtgtatttta   2880

taaaattaaa gaaaataaaa ttaagaatgt tctcaatcaa aaaaaaaaaa aaa          2933


<210>  102
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  102

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 
        115                 120                 125             


Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 
    130                 135                 140                 


Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
145                 150                 155                 160 


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 
                165                 170                 175     


Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 
            180                 185                 190         


Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 
        195                 200                 205             


Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 
    210                 215                 220                 


Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 
225                 230                 235                 240 


Lys Phe 
        


<210>  103
<211>  1049
<212>  DNA
<213>  Homosapiens

<400>  103
cgagcggcac gtgtcaggcc accgaggtcc aagccgcact tgctgcccca ttgaggacga     60

ggaggcagca ggagcagtga cggtgactct aaggagccgg attcccggca cgcagagctg    120

acctgcctgg cacccgcggc cctctcctgt ttccttccca ttgtgttggc accctaaaaa    180

gaaagaataa aacaacaaca ggaaaaaaag gaaaatattt aaattgtgac aaaaacccac    240

tgggttctct tggttacaaa ctccttccct tctggtgctg caaaaatgag tgggaaatcc    300

ctgctcttaa aggtcattct cttgggtgat ggtggagttg ggaaaagttc gcttatgaac    360

cgttacgtaa ccaacaaatt tgactcccag gcttttcaca ccataggggt agagttctta    420

aatcgagatc tggaggtaga tggacgcttt gtaaccctcc agatctggga cactgcaggg    480

caggaacgtt tcaagagcct taggacaccc ttctacaggg gagcagactg ctgcctcttg    540

accttcagcg tggatgatcg gcagagcttc gagaatcttg gtaactggca gaaagaattt    600

atttactatg cggatgtgaa ggaccctgag catttcccct ttgtagttct gggtaacaag    660

gtagacaaag aggataggca agtgactact gaggaggcac aaacctggtg catggagaat    720

ggggattacc cttatttaga aactagtgcc aaagatgata ctaatgtgac agtggccttt    780

gaagaagctg tcaggcaggt gctggctgta gaggaacagc tggagcattg catgttgggt    840

cacaccattg acttgaacag tggctccaaa gcagggtctt cgtgctgtta aagataggga    900

gccttttaaa aatgtgcccc aaattgatca gtcagtagtg taagaataac tgtgcccctc    960

taagagtgca cacacacgca cacaagaggg taagagacaa ggttctgatt gtgaaacaga   1020

gcctttcaaa ttgaagtgta gattgattt                                     1049


<210>  104
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  104

Met Ser Gly Lys Ser Leu Leu Leu Lys Val Ile Leu Leu Gly Asp Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Met Asn Arg Tyr Val Thr Asn Lys Phe 
            20                  25                  30          


Asp Ser Gln Ala Phe His Thr Ile Gly Val Glu Phe Leu Asn Arg Asp 
        35                  40                  45              


Leu Glu Val Asp Gly Arg Phe Val Thr Leu Gln Ile Trp Asp Thr Ala 
    50                  55                  60                  


Gly Gln Glu Arg Phe Lys Ser Leu Arg Thr Pro Phe Tyr Arg Gly Ala 
65                  70                  75                  80  


Asp Cys Cys Leu Leu Thr Phe Ser Val Asp Asp Arg Gln Ser Phe Glu 
                85                  90                  95      


Asn Leu Gly Asn Trp Gln Lys Glu Phe Ile Tyr Tyr Ala Asp Val Lys 
            100                 105                 110         


Asp Pro Glu His Phe Pro Phe Val Val Leu Gly Asn Lys Val Asp Lys 
        115                 120                 125             


Glu Asp Arg Gln Val Thr Thr Glu Glu Ala Gln Thr Trp Cys Met Glu 
    130                 135                 140                 


Asn Gly Asp Tyr Pro Tyr Leu Glu Thr Ser Ala Lys Asp Asp Thr Asn 
145                 150                 155                 160 


Val Thr Val Ala Phe Glu Glu Ala Val Arg Gln Val Leu Ala Val Glu 
                165                 170                 175     


Glu Gln Leu Glu His Cys Met Leu Gly His Thr Ile Asp Leu Asn Ser 
            180                 185                 190         


Gly Ser Lys Ala Gly Ser Ser Cys Cys 
        195                 200     


<210>  105
<211>  996
<212>  DNA
<213>  Homosapiens

<400>  105
atggggtttg atttctcaca cttcttcatc aagcatggct tgaagaagga agacattatg     60

acagacccat ttgaaaatct gcaaagctgt ggactcagaa gaatgtacgg agtccagatt    120

ctttgcatac agttccagga aggaccgcgg caaccgcggc tgcccggagg tccgaactgg    180

agggtggccg cagccgtgac ttccttggga accgcgctgc ctcgactcgg ctacctctct    240

gcgaagcact cgctaagccg ggcagccccg gggtcgctta gcggcccagg aggcgccagc    300

gatcctgttc ccctgcagag ctatggggac cggaaggcga aacagagctg tcgacgcggg    360

agcatacgct gcccaccagt ggagcgcagg tcatcaaagc cgaatccgaa tttgaattct    420

gtgcggctga ttgcagagct ggtaggccga cggtttcccg caggaaatgt ctcctactac    480

taccaaatct gtatcagcaa cagcagcagc tccaaggaca gtatgtgtgg caatgcaagt    540

acctgctgtc atgacatcag aaaatttcaa ctatggcggt tgactgcctc caagatggct    600

gagccttcct ctgagatgac ctccaacaaa ggcctgagca ccaaggagcc caaagcggcc    660

aatgccacga tggcccacaa gcagaagagg catgggcact ctcaccccag ccgctgcagg    720

gacagcttca ccacctattt tccccgggtg ctgaagcagg ttcacgcggg cctcagcctt    780

tcccccgagg cagtggatgt catagattcc ttcgttcacg acatcttgga gcacatcgcc    840

accaaggccg gccacttggc ccactatacc aagtgcacca ccatcacctc ctgcgagatg    900

cagaccacca ttcgcctgat gttcccgggg cagatgggca agcacgccat atccaggggc    960

tccaagactc tgctccacta caccaggagc aagtga                              996


<210>  106
<211>  331
<212>  PRT
<213>  Homosapiens

<400>  106

Met Gly Phe Asp Phe Ser His Phe Phe Ile Lys His Gly Leu Lys Lys 
1               5                   10                  15      


Glu Asp Ile Met Thr Asp Pro Phe Glu Asn Leu Gln Ser Cys Gly Leu 
            20                  25                  30          


Arg Arg Met Tyr Gly Val Gln Ile Leu Cys Ile Gln Phe Gln Glu Gly 
        35                  40                  45              


Pro Arg Gln Pro Arg Leu Pro Gly Gly Pro Asn Trp Arg Val Ala Ala 
    50                  55                  60                  


Ala Val Thr Ser Leu Gly Thr Ala Leu Pro Arg Leu Gly Tyr Leu Ser 
65                  70                  75                  80  


Ala Lys His Ser Leu Ser Arg Ala Ala Pro Gly Ser Leu Ser Gly Pro 
                85                  90                  95      


Gly Gly Ala Ser Asp Pro Val Pro Leu Gln Ser Tyr Gly Asp Arg Lys 
            100                 105                 110         


Ala Lys Gln Ser Cys Arg Arg Gly Ser Ile Arg Cys Pro Pro Val Glu 
        115                 120                 125             


Arg Arg Ser Ser Lys Pro Asn Pro Asn Leu Asn Ser Val Arg Leu Ile 
    130                 135                 140                 


Ala Glu Leu Val Gly Arg Arg Phe Pro Ala Gly Asn Val Ser Tyr Tyr 
145                 150                 155                 160 


Tyr Gln Ile Cys Ile Ser Asn Ser Ser Ser Ser Lys Asp Ser Met Cys 
                165                 170                 175     


Gly Asn Ala Ser Thr Cys Cys His Asp Ile Arg Lys Phe Gln Leu Trp 
            180                 185                 190         


Arg Leu Thr Ala Ser Lys Met Ala Glu Pro Ser Ser Glu Met Thr Ser 
        195                 200                 205             


Asn Lys Gly Leu Ser Thr Lys Glu Pro Lys Ala Ala Asn Ala Thr Met 
    210                 215                 220                 


Ala His Lys Gln Lys Arg His Gly His Ser His Pro Ser Arg Cys Arg 
225                 230                 235                 240 


Asp Ser Phe Thr Thr Tyr Phe Pro Arg Val Leu Lys Gln Val His Ala 
                245                 250                 255     


Gly Leu Ser Leu Ser Pro Glu Ala Val Asp Val Ile Asp Ser Phe Val 
            260                 265                 270         


His Asp Ile Leu Glu His Ile Ala Thr Lys Ala Gly His Leu Ala His 
        275                 280                 285             


Tyr Thr Lys Cys Thr Thr Ile Thr Ser Cys Glu Met Gln Thr Thr Ile 
    290                 295                 300                 


Arg Leu Met Phe Pro Gly Gln Met Gly Lys His Ala Ile Ser Arg Gly 
305                 310                 315                 320 


Ser Lys Thr Leu Leu His Tyr Thr Arg Ser Lys 
                325                 330     


<210>  107
<211>  1072
<212>  DNA
<213>  Homosapiens

<400>  107
ctttccgggc taccttgtag caatttgagg ctccgtcatc agtttctgct acgtttcaaa     60

gatccaggag aagcttagtg ttgtgtcaag acgccgatgg acccatcaca gaagtttaat    120

ccaacctaca tcccagagtc tccacaaatg ctcaccgaag aaaattcccg ggacgattca    180

ggggcctctc aaatctgctc cgagacgttg ataaagaacc ttagtaactt gactatcaac    240

actagtagcg aatctgtttc ccctctatcg gaagctttac tccgtcgaga gtctgtagga    300

gcagaagtcc tcagggaaat cgaagatgag tggctttaca gcaggagagg agtaagaaca    360

ttgctgtctg tgcagagaga aaagatggca agatcgagat acatgttact cggcagagtt    420

cgtatgcatg aaagaagacc aacaaacgag gagcctaagg gagttaagaa ggaatcaaga    480

ccattcaaat gtccctgcag tttctgcgtg tctaacggat gggatccttc tgagaatgct    540

agaatagaga atcaagacac caagccactt cagccataaa tcttattctt gcaccttttt    600

ttcttgctgg taattttata tagcaggttg agaaagctaa tctatgctag aacagactat    660

acaccaataa ttttgataat gagttctagg atgtattttt cttcttgtat ctttttcttc    720

ctactatgat actagtaatt cataagggat ctgtgtaatc tgaatgtatt tgaataactt    780

tagctctact gtttgatttg acccaaagaa tccaagacga tataagtatt cccatgtgtc    840

ttagaagccc aaagtcagtg agatgaaacc caacatcaag aaattgaagc aaagttactt    900

gtggataaag aaagcattag gtagtttggc tatagcataa ttagattttc tggctttcaa    960

aaatttgaac tgcaatcaca gcaaactttg ttatttttac agttttcagt acaaaaaggt   1020

gtttatatag aaacaataaa gttgacattt gagtaccttt aaaaaaaaaa aa           1072


<210>  108
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  108

Met Asp Pro Ser Gln Lys Phe Asn Pro Thr Tyr Ile Pro Glu Ser Pro 
1               5                   10                  15      


Gln Met Leu Thr Glu Glu Asn Ser Arg Asp Asp Ser Gly Ala Ser Gln 
            20                  25                  30          


Ile Cys Ser Glu Thr Leu Ile Lys Asn Leu Ser Asn Leu Thr Ile Asn 
        35                  40                  45              


Thr Ser Ser Glu Ser Val Ser Pro Leu Ser Glu Ala Leu Leu Arg Arg 
    50                  55                  60                  


Glu Ser Val Gly Ala Glu Val Leu Arg Glu Ile Glu Asp Glu Trp Leu 
65                  70                  75                  80  


Tyr Ser Arg Arg Gly Val Arg Thr Leu Leu Ser Val Gln Arg Glu Lys 
                85                  90                  95      


Met Ala Arg Ser Arg Tyr Met Leu Leu Gly Arg Val Arg Met His Glu 
            100                 105                 110         


Arg Arg Pro Thr Asn Glu Glu Pro Lys Gly Val Lys Lys Glu Ser Arg 
        115                 120                 125             


Pro Phe Lys Cys Pro Cys Ser Phe Cys Val Ser Asn Gly Trp Asp Pro 
    130                 135                 140                 


Ser Glu Asn Ala Arg Ile Glu Asn Gln Asp Thr Lys Pro Leu Gln Pro 
145                 150                 155                 160 


<210>  109
<211>  1729
<212>  DNA
<213>  Homosapiens

<400>  109
tgcagggctc tgggcgggaa ggctaacctg gtgcggagcc agcctgggtc tcagccccgc     60

gtacggcctt tcacgagtct tcaagccttc aggctttctt ctagtcaaga tgagtgataa    120

accagacttg tcggaagtgg agaagtttga caggtcaaaa ctgaagaaaa ctaatactga    180

agaaaaaaat actcttccct caaaggaaaa acttcattat gtgcgatatg gcaagagaga    240

aagtgaatac gctgatataa gaagcaagaa accttccttc cttccagatg tgtgtcagta    300

gaattacaga gtgtccacgg aaacagctca tgccctagtg tacagtggtg cagccaatga    360

gtgacctgaa gtctatgagc aacactcatt gtcccaatgt gggacgagtg accgaagctg    420

aacccacaac agccttcctg tgatattcca cgtggtggtt aaaggcatgg cgatgtgatt    480

ctttacctga tgtttttgtt tgcagtgttt gtaatcatgg tcttttaggg atatgaatcc    540

aaagctaaga ttaatatacg ttccttgacc ctaacatcaa gttatacaga gcattgtcag    600

ccattagaag aagtcagata acgcttattt cctcaaaaga ttggcatatt aatattcacg    660

ttaatattaa tacaggctac ctttcattgt gctctcttct gggtcccaag tcttggtatt    720

tttagaattt ttttttttct ataagtgtat tgctgaattt cagagcaggt gctgacttac    780

ccattgcttt ccttttccat tgatttccag tcgcccgagt atgtggacaa gagaacatac    840

tctgggattg caacccacag gaatttatta tgttgtgcct tgaagctcaa tatgtggcca    900

tttttgttaa atgtttcccg taaattttga aacatctcat aaacaaccct tctccttcat    960

atgtagaaac cagtaaagga tggcactctc agtcaaacca cgaagcaaaa gctggataaa   1020

tgacaaaaat caaaattttc ttgagcccgt cagaagtggg aaagaaccac cccagaggga   1080

cccaacacat agccacatag attatttcac catttaaaga ggaccccttg gtcaagaggg   1140

aaaagggttc ggggcaggat agtagccaga gcttccctga gtagtgcaga tgggaagagg   1200

ggaaggtcac ctccagagct ccacttggga tccatagaga aatgatatag aaccaagaag   1260

tccactcact gggatttgtt actttctgtt tttccagaat attagaaaaa tattatgaaa   1320

atagttgaag agaaatgtta tgaaaatagt tgaaggagac caagaaaaac tcccacaaaa   1380

tcagctgcaa gtaaatccct ctggatggtg ccgccacatg ttcctacaag tccagaacaa   1440

cccttgccaa accaaagaca cttggcagaa ccctgttcct ttctagagac agagctgtat   1500

acctgttcca aaacaccaca tctcactcag tgacttattt ctcattatgc taattgtttt   1560

gctgtaaagt gccaatgttt ctgtgaatta agacatacga ataaatttct gaagttaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa               1729


<210>  110
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  110

Met Ser Asp Lys Pro Asp Leu Ser Glu Val Glu Lys Phe Asp Arg Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Asn Thr Glu Glu Lys Asn Thr Leu Pro Ser Lys 
            20                  25                  30          


Glu Lys Leu His Tyr Val Arg Tyr Gly Lys Arg Glu Ser Glu Tyr Ala 
        35                  40                  45              


Asp Ile Arg Ser Lys Lys Pro Ser Phe Leu Pro Asp Val Cys Gln 
    50                  55                  60              


<210>  111
<211>  935
<212>  DNA
<213>  Homosapiens

<400>  111
gaagctggcc cgagatgtgg agccatgctg cgtaccgaag tgccccggct tccccggtcc     60

acaaccgcca ttgtctggtc gtgccatcta atggccactg cctccgccat ggctggacct    120

tcctctgaga cgacctctga ggaacagctg atcacccagg agcccaaaga ggccaactcc    180

actacgtccc agaagcagag caagcagagg aagcgagggc gccatgggcc ccgcaggtgc    240

cactccaact gccgcgggga cagcttcgcc acctatttcc gccgggtgct gaagcaggtt    300

caccagggcc tcagcctttc ccgggaggcc gtgagtgtca tggattcttt ggttcatgac    360

atattggacc gcatcgccac cgaggctggt cacctggccc gctccaccaa gcgccagacc    420

atcactgcct gggagacccg gatggctgtg cgcctgctgc tgccggggca gatgggcaag    480

ctcgccgagt ccgaaggcac gaaggctgtc ctcagaactt cactgtatgc catacagcaa    540

cagagaaagt gaatacgctg atacaagaag caagaatatt agaaaaatgt catgaaaata    600

gttgaagaga aatgctcact gcacaaggag accaagaaaa accccccacg aaatcagcca    660

caactaaatc gctctggacg gtgccgccag gtgaccctac atgtccggag caacactttg    720

aaaaccaaag acgcttggca gaaccctgtt cctttccaga gacagagctg tgtaccttgt    780

ctaaaacacc gcatctcact cagtgactta tttctcatta tgctaattgt tttcgcttta    840

aagcgccagt ctttctgtca aatgggacat acaaataaat ttctaaaatt aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaag aaaaaaaaaa aaaaa                               935


<210>  112
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  112

Met Leu Arg Thr Glu Val Pro Arg Leu Pro Arg Ser Thr Thr Ala Ile 
1               5                   10                  15      


Val Trp Ser Cys His Leu Met Ala Thr Ala Ser Ala Met Ala Gly Pro 
            20                  25                  30          


Ser Ser Glu Thr Thr Ser Glu Glu Gln Leu Ile Thr Gln Glu Pro Lys 
        35                  40                  45              


Glu Ala Asn Ser Thr Thr Ser Gln Lys Gln Ser Lys Gln Arg Lys Arg 
    50                  55                  60                  


Gly Arg His Gly Pro Arg Arg Cys His Ser Asn Cys Arg Gly Asp Ser 
65                  70                  75                  80  


Phe Ala Thr Tyr Phe Arg Arg Val Leu Lys Gln Val His Gln Gly Leu 
                85                  90                  95      


Ser Leu Ser Arg Glu Ala Val Ser Val Met Asp Ser Leu Val His Asp 
            100                 105                 110         


Ile Leu Asp Arg Ile Ala Thr Glu Ala Gly His Leu Ala Arg Ser Thr 
        115                 120                 125             


Lys Arg Gln Thr Ile Thr Ala Trp Glu Thr Arg Met Ala Val Arg Leu 
    130                 135                 140                 


Leu Leu Pro Gly Gln Met Gly Lys Leu Ala Glu Ser Glu Gly Thr Lys 
145                 150                 155                 160 


Ala Val Leu Arg Thr Ser Leu Tyr Ala Ile Gln Gln Gln Arg Lys 
                165                 170                 175 


<210>  113
<211>  1964
<212>  DNA
<213>  Homosapiens

<400>  113
atgaaattgg ccatcacaga gctaaatgtt gatcatcgga gccatgcgac cataccaaag     60

tgccccccac ttccctggtc cccaaccgtc actctctgtt cttgctatct aatggccgct    120

gcttccgcca tggctgaggc ttcctctgag acaacctcgg aggaaggcca gagcatccag    180

gagcccaaag aggccaactc cacgaaggcc cagaagcaga agaggcgagg gtgccgaggc    240

tcccgcaggc gccacgccaa ccgccgtggg gacagcttcg gggacagctt caccccctat    300

ttcccccggg tgctgaagca ggttcaccag ggcctcagcc tttcccagga ggccgtgagt    360

gtcatggatt ctatgatcca tgacatattg gaccgcatcg ccaccgaggc tggtcagctg    420

gcccattaca ccaagcgcgt gaccatcacc tcccgggaca tccagatggc cgtgcgactg    480

ctgctgccgg ggaagatggg caagctcgcc gaggcccagg gcacgaatgc cgccctcaga    540

acttcattat gtgcgatatg gcaacagaga aagtgaatat gctgatacaa gaagcaagaa    600

accttcctta cttccaggtg tgtgtcagta ggattacgga gtgtccacgg aaacagctca    660

tgccctagtg tacagtggta cagccaatga gtgacctgca gtctatgagc aacagtcatt    720

gacccaatgt ggggggagtg acccaagctg aacccacagc agccttcctg ttatattcaa    780

cctggtgttt aaaggaacgg cagtgtgatt ctttacctga tgtttttgtt tgcattgctt    840

gtaatcatga tcttttaggg atatgaatcc aaagctaaga ttagaatatg taccttgtcc    900

ctaacatcaa gttatacaga acattggcaa ccattagtag aagtcagata aggcttattt    960

cctcaaaaga ttagcatatt tatattcatg ttaatattaa tataggctac ctttcattgt   1020

gctctcttct gggtcccaag tcttggcatt ttaagcattt ttttctataa gtgtattgct   1080

gaatttcaga gcaggtgctc actttcccat tgctttcctt ttccattgat ttccagtcgc   1140

ccgagtatgt ggacaagaga acatactctg ggactgcaac ccacaggaat ttattatgtt   1200

gtgccttgaa gctcaacatg tggccatttt tgttaaatgt ttcccgtaaa ttttgaaaca   1260

tctcataaac aacccttctc cttcatatgt agaaaccagt aaaggatggc actctcagtc   1320

aaaccatgaa acaaaagctg gataaatgac aaaaatcaaa attttcttga gcccatcaga   1380

agtgggaaag aaccacccca gagggcccaa cacatagcca catagattat tccaccattt   1440

aaagaggacc ccttggtcaa gagggaaaca gggtcagggc aagatggtag ccagagcttc   1500

cctgagtagt gcagatggga agaggggaag gtcacctcca gagctccact tgggatccat   1560

agagaaatga tatagaacca agaagtccac tcattgggat ctgttacttt ctgtttttcc   1620

agattattag aaaaatatta cagaaatagc tgaagagaaa tgttatgaaa atagttgaag   1680

ttgtgcttat tgcacgagga gaccaagaaa aaccccacaa aatcagctgc aagtaaatcc   1740

ttctggatgg tgccaccaaa tgttcctaca agtccggaac aacccttgcc aaaccaaaga   1800

cccttgccag aaccctgctt cttcccagag acagagctgt gtacctgaca aaacaccaca   1860

tctcactcag tgacttattt ctcattatgc taattgtttt gctgtaaaat gccaatgttt   1920

ctgtgaatta agacatacga ataaatttct gaagttaccc ttgc                    1964


<210>  114
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  114

Met Lys Leu Ala Ile Thr Glu Leu Asn Val Asp His Arg Ser His Ala 
1               5                   10                  15      


Thr Ile Pro Lys Cys Pro Pro Leu Pro Trp Ser Pro Thr Val Thr Leu 
            20                  25                  30          


Cys Ser Cys Tyr Leu Met Ala Ala Ala Ser Ala Met Ala Glu Ala Ser 
        35                  40                  45              


Ser Glu Thr Thr Ser Glu Glu Gly Gln Ser Ile Gln Glu Pro Lys Glu 
    50                  55                  60                  


Ala Asn Ser Thr Lys Ala Gln Lys Gln Lys Arg Arg Gly Cys Arg Gly 
65                  70                  75                  80  


Ser Arg Arg Arg His Ala Asn Arg Arg Gly Asp Ser Phe Gly Asp Ser 
                85                  90                  95      


Phe Thr Pro Tyr Phe Pro Arg Val Leu Lys Gln Val His Gln Gly Leu 
            100                 105                 110         


Ser Leu Ser Gln Glu Ala Val Ser Val Met Asp Ser Met Ile His Asp 
        115                 120                 125             


Ile Leu Asp Arg Ile Ala Thr Glu Ala Gly Gln Leu Ala His Tyr Thr 
    130                 135                 140                 


Lys Arg Val Thr Ile Thr Ser Arg Asp Ile Gln Met Ala Val Arg Leu 
145                 150                 155                 160 


Leu Leu Pro Gly Lys Met Gly Lys Leu Ala Glu Ala Gln Gly Thr Asn 
                165                 170                 175     


Ala Ala Leu Arg Thr Ser Leu Cys Ala Ile Trp Gln Gln Arg Lys 
            180                 185                 190     


<210>  115
<211>  951
<212>  DNA
<213>  Homosapiens

<400>  115
atgcaatcag atgtcgagtt ggactgtgac atagagccat gtggccacac taaattcccc     60

cccacccttc ccctgtccac aaccgtcatt gtctgttctt gccatccagt ggccactgcc    120

tccaccatgg ctgaggcttt ctctaagaca acctctgagg aagaccagag catccaggag    180

cccaaagagg ccaactccat gacggcccag aagcagaaga actttgccgc ctatttcccc    240

cgggtgctga agcaggttca ccaggccctc agcctttccc aggaggccgt gagtgtcatg    300

gattctatgg ttcgtgacat actggaccgc atcgccaccg aggctggtca cctggcccac    360

tactccaagt gcgtgaccat cacctcccgg gacattcgga tggccgtgtg cctgctgctg    420

ccggggaaga tgggcaagct cgctgagtct cagggcacga atgccaccct caggatagaa    480

tcttttgttt ttgaaaatct tcatgactgg cctctacgtg tcatggggat catggaatgc    540

tgtccgatgg cgcagcacaa gctccactcg gatccattgg catcggccgc tttccgctcc    600

ttcgtgctca ggcctttgtc agaggtcgtc tcagaggaag gcttaaccat ctcagaggca    660

actgccagtg gatgtgagtg ttggggagca ggtcgaccga cacccacagt gattgccaag    720

caacgagacc atcgaatcgc ctccaaggcc aggaggcttg ctgataggct ccctgcgtgg    780

cacttcattc agtcagatgt ggagttgctg gcccgtgaca taagccatgg ggtgactaca    840

aaaggccatc ccgctggtgg tcagccatca ttgtccgttc ctcacatcca ctggcagttg    900

cctccaagat ggctgagcct tcctctgaga caacctccaa tgaatgcctg a             951


<210>  116
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  116

Met Gln Ser Asp Val Glu Leu Asp Cys Asp Ile Glu Pro Cys Gly His 
1               5                   10                  15      


Thr Lys Phe Pro Pro Thr Leu Pro Leu Ser Thr Thr Val Ile Val Cys 
            20                  25                  30          


Ser Cys His Pro Val Ala Thr Ala Ser Thr Met Ala Glu Ala Phe Ser 
        35                  40                  45              


Lys Thr Thr Ser Glu Glu Asp Gln Ser Ile Gln Glu Pro Lys Glu Ala 
    50                  55                  60                  


Asn Ser Met Thr Ala Gln Lys Gln Lys Asn Phe Ala Ala Tyr Phe Pro 
65                  70                  75                  80  


Arg Val Leu Lys Gln Val His Gln Ala Leu Ser Leu Ser Gln Glu Ala 
                85                  90                  95      


Val Ser Val Met Asp Ser Met Val Arg Asp Ile Leu Asp Arg Ile Ala 
            100                 105                 110         


Thr Glu Ala Gly His Leu Ala His Tyr Ser Lys Cys Val Thr Ile Thr 
        115                 120                 125             


Ser Arg Asp Ile Arg Met Ala Val Cys Leu Leu Leu Pro Gly Lys Met 
    130                 135                 140                 


Gly Lys Leu Ala Glu Ser Gln Gly Thr Asn Ala Thr Leu Arg Ile Glu 
145                 150                 155                 160 


Ser Phe Val Phe Glu Asn Leu His Asp Trp Pro Leu Arg Val Met Gly 
                165                 170                 175     


Ile Met Glu Cys Cys Pro Met Ala Gln His Lys Leu His Ser Asp Pro 
            180                 185                 190         


Leu Ala Ser Ala Ala Phe Arg Ser Phe Val Leu Arg Pro Leu Ser Glu 
        195                 200                 205             


Val Val Ser Glu Glu Gly Leu Thr Ile Ser Glu Ala Thr Ala Ser Gly 
    210                 215                 220                 


Cys Glu Cys Trp Gly Ala Gly Arg Pro Thr Pro Thr Val Ile Ala Lys 
225                 230                 235                 240 


Gln Arg Asp His Arg Ile Ala Ser Lys Ala Arg Arg Leu Ala Asp Arg 
                245                 250                 255     


Leu Pro Ala Trp His Phe Ile Gln Ser Asp Val Glu Leu Leu Ala Arg 
            260                 265                 270         


Asp Ile Ser His Gly Val Thr Thr Lys Gly His Pro Ala Gly Gly Gln 
        275                 280                 285             


Pro Ser Leu Ser Val Pro His Ile His Trp Gln Leu Pro Pro Arg Trp 
    290                 295                 300                 


Leu Ser Leu Pro Leu Arg Gln Pro Pro Met Asn Ala 
305                 310                 315     


<210>  117
<211>  6241
<212>  DNA
<213>  Homosapiens

<400>  117
gggaagcaaa gaggattgtg ggagctccgt tgtgcgtcgc ttaagtgagg gcggcggatg     60

ggcgaaggtc cggtgactgc gactgtcgct gctttctgag gccacaggaa aggggccgtc    120

ggtcgccgcc atgacagcga gcgaggcgga gtttcttcca tctgcaccca gttgtcttca    180

gcatggggga gcagaaccac tctcccggga aggagcttca gcacaggacg cgagcagagg    240

ctccaggaaa gaaaagctgg cattcccagg cctatgccct tggggccgtt tccaacttta    300

tgtctacttt tctgaccttt cctatctata aggttgtgtt ccggcaacag atccatgcca    360

tggcagtgtc agaggctgtg agacagcttt ggcatgaagg tcctcaatac ttctaccggg    420

gaatctaccc tcctcttctc tccaagacgt tgcaagggac tcttctgttt gggacttatg    480

atagcctgct gtgctttctc tctcctgttg ggccacacac cctgggacac cgctgggctg    540

ccgggctcat gtctggcgtg gtggaggccg tggcactcag cccctttgaa agggtgcaaa    600

atgtgctcca ggatggtcgc aagcaagctc gcttccccag caccttctgc attctcaagg    660

aattcaattc ttatgggctt tgggggcggc tgtcactggg ctactatcgt ggtttctggc    720

ctgtcctggc caggaacagc ctggggagtg ctctatattt ttctttcaag gaccccatcc    780

aggatggcct ggcagagcaa ggcctgcccc actgggttcc tgccttggtg tctggtagtg    840

tcaatggaac aatcacctgc ctagttctgt atcctctgat tgtgctggtt gctaatatgc    900

agtcccatat tggatggcag aacatgccaa gcctgtgggc ctctgcccag gatgtatgga    960

acactcgggg ccgaaagctg ctcctgatct accgtggagg ctccctagtc atcctaaggt   1020

ccagtgtgac atggggcctc actacggcaa tccatgactt cctgcagagg aagtcgcact   1080

ccaggaaaga gctgaagact gactagctgc agaaagtgtg gcatggcagc tttgttattc   1140

taaatcttcc ctggttggtt ctatatagct tacttctttg gctaggttgc ctaatacagc   1200

catcctttag catctataaa ctcattgcat gggagaagtt cccaactacc aacctgttga   1260

gcaaggacaa agcccaaaag tattccttag tcaaaaagaa acgttcaccc cagtctctcc   1320

acagtttcag tagcctcaga gccaggaggc ctttaaataa catgtaaccc agattaagtg   1380

tcattccttt aaggaattcc ttggcaataa acagaaactt aaaaagatga ccttacttag   1440

gcactctgag ctctgggacc cctctaggtg tcctccagac caaactgagt ggaactccaa   1500

tttcaaagaa ctatgcttga ctcttaggat gggaattcca taaaacttct cagatggcta   1560

cattttcatg atattgttca ctgcctctac caccacctct cacttctcaa ggctgtgggt   1620

cctactttca gggtagcagc tgtggctgga aatcctaaat taggcttgca tgaactcgtc   1680

aggtgccaca agaactagtg gggctggaga tgggagtgag aagaggcgtg gcccatggat   1740

ggaaagaata aaaactttga aagaaaagat ttaattacat gcaaaataga aacatttgct   1800

atagtctgct tggtgttatc tgctaggaca tttccgagag caaggtgata acattgccta   1860

gaaaccgttt gagtttccct aagaaacctg gaaatgaagt gaccatatct cttcacagaa   1920

aattgcatat tttgttgatg tggttaaatg tagttactat gacataaaga tcagaaatct   1980

tagcctgtca ttcagagcca ttcaaaatat ggtcatcata taactttcaa catattgtca   2040

ctccacttac ataaacccca aacactagcc ataatgaact attgttctct ccccagacat   2100

tccatgaact ttcccatggc catactctgg cccacactat tctttccacc tgcagtgctc   2160

cttcttcaca tgccagtcta ccaaaatcct tccagttcct tgaagcccag ctcagaggtc   2220

accttctcta tggagttctt gattttcccc tactgaatgt gacattagtc tctgtgatgc   2280

ccctttcttt tttttttttt tgagacggag tttcgctctt gttgcccagg ctggagtgcc   2340

aatggtgtga tctcagctca ctgcaacctc cacctcccgg attcaagtga ttctcctgcc   2400

tcagcctccc gagtagctgg aattacaggc gcccaccacc atgcctggct aattttgtat   2460

ttttagtaga gatggggtct ctccatgttg gtcaggctgg tctcgaactc ccaacctcat   2520

caggtgatcc acccacctcg gtctcccaaa gtgctgggat tacaggcgtg agccaccgcg   2580

cccagcctct gtgatgcccc tttctaacag cacttcatac agggtactga ttccattatg   2640

tcactaatct catgtgaccc tttgttcttg tattcttcaa tacctcctac tagactgtaa   2700

aactcattga aagcagggat ttttgtatgc attttaaaat cttccattgt gcctaggtgc   2760

tcaataacgt tggtcaaatt actgagttga ttatcaagct gtgatatggt atatcctcag   2820

ggtgctgtcc cttgtacatg acgataaagt tattgactca ctgtcagcaa gacacgtgcc   2880

tttgggctgt gtttttgctt tcttttaata attgatttag ttttgtgcta atgataatga   2940

tgctgctact gataataata ataacaataa taaaaattac tttcaactgg cacatttgat   3000

gagtttatat tactgatggc atgtttgcta ttagcaccag ttcaggaact gaaatttcac   3060

aaacagaatc acactgtaca actgtaccat ttgtttcaac tctggaattt tgaggatttc   3120

caagatgaca tgtgttatag tttcccccta cagatatctt agtaatgccc tcctcttgca   3180

tctccttact gaaccaaatt tgtcctgtat ttgtcttact tggttgtaga tttagcagtg   3240

agaacttctc actgaatgcc acagaaatta aagacatggt tgttggaggt atgatgtcag   3300

agagcatttg ccaccaaggt tggcagaaaa tggctggtcc aggagagctg aagatgagct   3360

tccacatctg cagatcggga tgtgttggga cagtactcaa cttgtggatt caaggaagta   3420

tgaacacaga gtctgcataa ggaaaggaaa aagatgcatt catctcccaa gtacaccggt   3480

gatttccact tatgtcattc tgtccatcca tgtccctttc ttcattttaa cttcttattt   3540

aaaaataatt tcaaacattt aaaaatgttg caagcataaa taaagcttaa agaacaccca   3600

tgtccccttt accctaattc ccctattatt aatgtttctc cccatttgct ttattattta   3660

agtgtgcact ctgtctatac acacacagga tattttttcc ctgaactatc tgagagttgc   3720

atacatcagt tttcaatatt cctagattca atgtttgtag atccaaatta ttttttaaga   3780

gaccgtgttt tatctctgac aatgggacag ttattacaga atataataaa atgaaaactc   3840

acacaatata tgtgatattg tgaaatatat acttggtctt tgatcctgtt tcttggcata   3900

caactcctaa aatccttaga atttccaaag tgatatcttt ttgtatgcta ataattgact   3960

gatggctggc agcctctggt tgcttcagga tgggaactag tcaccaggaa gaccaaggca   4020

ccattagagg gttgggactt aacagcctca ttcccgacct ccagggaggg gagagggatg   4080

gaaggttaag ttgatcacca gtggccaatg atttaatcaa tcatgcctac gcaatgaagc   4140

ttccataaaa accccaaagc actgggtttg gagagcttcc agatagctga acatgtggag   4200

gttcctggag ggtggtgacc cagggagggc acagaagctc tgagcccctt ccgcagtacc   4260

tcaccctatg catctcttca tctctatcct ttgatatatc ctttataata aagtggtaaa   4320

cgttaagtat ttccccaagt tctgtgaccc tttctggcaa attaaaccca aagaaggggt   4380

catgtgaact caaacttgaa gcccatctgt cagaagttct ggaggcttgg atttgcgact   4440

ggtgtctgaa gggcctggga acagtcttgt gaaacctagt cctcagcttg tgggatatga   4500

cgctatctcc aggtagattg tgtcagaatg gaattggagt acacccagct ggtgttcgct   4560

gcagaactga ttgctcactt agtgtgtggg aaaactccac acatctggac atggaaatat   4620

tctgtgctga ttgccgtggt gtaagagcaa tgcaaaaagt ttgggtattt tcccctcgga   4680

gtatattttg aagctaaatt gctaataatt gcttaaattt actatatttg cctttataaa   4740

aactttatgt atgttgaagc ttgaagctat gcaattataa tataaacatg gatttacaac   4800

taaagcatgt tataatttaa ataattgagt ttttcaaatc ggttcatatg aaatcctagg   4860

caatattgta aaattataca gacctgtcaa ctttttccac ttaaaagttg tgagcaaaat   4920

ttaagggcat agtcgttttc aagtaatttt aaatgtcaat gttaatattt agtttagtga   4980

tgttaatgga gctatgtttt ctgatattaa aaatgagttt taggagttga gaccaataaa   5040

ataaggaggt aataaatatc tatatctgtt taaacacata aaatatacaa tttaacacta   5100

aaattacttg gtataaaaag tcaaaaaaag gaataaaaag ccatcataca acacaatata   5160

tgcgtgatat atatttttct ctaaatataa actacatcag cttttataaa gctcaagttg   5220

aaataataac gttttatgac aaatcattat atggtatatt ctgacttaat tttgcattta   5280

caatttattt ttaaacacta aatagcatta taattttact gggataacta tatatagtgt   5340

agtatattaa agttaataaa atgacgttgc atatgagaga aaaagcataa taaatcagaa   5400

acaatataaa aagctttcag aaaagataaa aatattgtat ttctctagtc tgttcactct   5460

ccagtgtctc tggttctttc atatcatctt cctttcctca aatcttttaa tactccctcc   5520

ctcatcattt ccaactagtg accctacttt ctatttcatt aagaaaacag atacattcag   5580

aagagaactg ccagtttaaa gaacatttac aaagccatca cccatgtaat aaccagccag   5640

agcaagaaat agagcccttt aataacctac tcttctcccc ccaccactga tgacaccgct   5700

ccctccatct taggtgtagc ccccatgctg acttttgtaa taataatttc tttgcttttg   5760

tttataagtt ttcttcctta taagcatctc taaacaacag ttttgtttta cagatgttca   5820

aacattaaat gctttttaga cttggaattg tgactatctt gtttcactcc acattgcttg   5880

tgagactcat tgatattgca gatagctgta gttgatccat ttttattgtt gtacagttta   5940

ccattgtata aatataccat gatttattca tgataacttt gaggaacatt ctggttgttt   6000

gcaggtttta tttttacagt tcattagttt tattgatgta taataattgt atatgtttat   6060

ggggtatatg tgatattttg atacatgtgt acaatgtgta atgattaaat caaggtaatt   6120

gggatatcca tcagctcaaa catttatcat ttctttgcat tgggaacatt ccaaatcttc   6180

tcttctagct attttgaaat acacaataaa ttgaatactg tggtcaaaaa aaaaaaaaaa   6240

a                                                                   6241


<210>  118
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  118

Met Gly Glu Gln Asn His Ser Pro Gly Lys Glu Leu Gln His Arg Thr 
1               5                   10                  15      


Arg Ala Glu Ala Pro Gly Lys Lys Ser Trp His Ser Gln Ala Tyr Ala 
            20                  25                  30          


Leu Gly Ala Val Ser Asn Phe Met Ser Thr Phe Leu Thr Phe Pro Ile 
        35                  40                  45              


Tyr Lys Val Val Phe Arg Gln Gln Ile His Ala Met Ala Val Ser Glu 
    50                  55                  60                  


Ala Val Arg Gln Leu Trp His Glu Gly Pro Gln Tyr Phe Tyr Arg Gly 
65                  70                  75                  80  


Ile Tyr Pro Pro Leu Leu Ser Lys Thr Leu Gln Gly Thr Leu Leu Phe 
                85                  90                  95      


Gly Thr Tyr Asp Ser Leu Leu Cys Phe Leu Ser Pro Val Gly Pro His 
            100                 105                 110         


Thr Leu Gly His Arg Trp Ala Ala Gly Leu Met Ser Gly Val Val Glu 
        115                 120                 125             


Ala Val Ala Leu Ser Pro Phe Glu Arg Val Gln Asn Val Leu Gln Asp 
    130                 135                 140                 


Gly Arg Lys Gln Ala Arg Phe Pro Ser Thr Phe Cys Ile Leu Lys Glu 
145                 150                 155                 160 


Phe Asn Ser Tyr Gly Leu Trp Gly Arg Leu Ser Leu Gly Tyr Tyr Arg 
                165                 170                 175     


Gly Phe Trp Pro Val Leu Ala Arg Asn Ser Leu Gly Ser Ala Leu Tyr 
            180                 185                 190         


Phe Ser Phe Lys Asp Pro Ile Gln Asp Gly Leu Ala Glu Gln Gly Leu 
        195                 200                 205             


Pro His Trp Val Pro Ala Leu Val Ser Gly Ser Val Asn Gly Thr Ile 
    210                 215                 220                 


Thr Cys Leu Val Leu Tyr Pro Leu Ile Val Leu Val Ala Asn Met Gln 
225                 230                 235                 240 


Ser His Ile Gly Trp Gln Asn Met Pro Ser Leu Trp Ala Ser Ala Gln 
                245                 250                 255     


Asp Val Trp Asn Thr Arg Gly Arg Lys Leu Leu Leu Ile Tyr Arg Gly 
            260                 265                 270         


Gly Ser Leu Val Ile Leu Arg Ser Ser Val Thr Trp Gly Leu Thr Thr 
        275                 280                 285             


Ala Ile His Asp Phe Leu Gln Arg Lys Ser His Ser Arg Lys Glu Leu 
    290                 295                 300                 


Lys Thr Asp 
305         


<210>  119
<211>  3028
<212>  DNA
<213>  Homosapiens

<400>  119
cgcaccccgg caagcagcag cgggccgcga cgcccagcct gccagtgagc tgcgacgggc     60

acaccccgga gcgtcggcga ctgcggacag gttagagtgg gggcaggggc gggcgcggga    120

gcagcccagg gccagagagg gagcccgagc caggccatct ccaaccatgt ccgacgaggc    180

ctcggccatc acttcctacg agaagtttct aacccccgag gagcccttcc cactcctggg    240

acctcctcgc ggggtgggca cctgcccgag cgaggagccg ggctgcctgg acatcagcga    300

cttcggctgc cagctgtcct cctgccatcg caccgacccg ctccaccgct tccacaccaa    360

caggtggaac ctaacttctt gtggaacaag tgttgccagc tcagaaggca gtgaggagct    420

gttttcatct gtgtctgttg gagatcaaga tgattgctat tccctgttag atgatcagga    480

cttcacttct tttgatttat ttcctgaggg gagtgtctgc agtgatgtct cttcttctat    540

tagcacttac tgggattggt cagatagcga gtttgaatgg cagttaccag gcagtgacat    600

tgccagtggg agtgatgtac tttctgatgt catacccagt attccaagtt caccttgcct    660

gcttcctaaa aagaaaaaca agcaccggaa tttagatgaa ctcccttgga gtgcaatgac    720

aaatgatgag caggtggaat atattgagta tctgagtcgg aaagtgagta ctgagatggg    780

tcttcgggag caacttgata ttattaagat cattgatcct tctgctcaaa tctcccctac    840

agacagtgag tttattattg aacttaactg tctcacagat gaaaaactga agcaggtcag    900

aaactatatc aaggaacata gccctcgcca acggcctgca agagaggcct ggaagagaag    960

caactttagt tgtgcaagca ccagtggagt gagcggtgcc agtgccagcg ccagcagcag   1020

cagtgccagc atggtcagtt ctgcaagcag cagtgggtcc agtgttggaa actctgcttc   1080

aaactccagt gccaacatga gtcgagcaca cagtgacagc aacctgtctg caagtgcagc   1140

agagcggatt cgggattcaa aaaagcgatc caagcagcgg aagttacagc agaaggcctt   1200

ccgcaagagg cagctgaagg agcagaggca ggcccggaag gagaggctca gtgggctctt   1260

ccttaacgaa gaggtgctgt ccttgaaagt gactgaggaa gaccatgaag cagatgttga   1320

tgttttgatg taataagggt gaatttatca acgttctttg tgagcattaa aatactccat   1380

ccttatgggt ttacatgcat cttgaccaaa attttggtta gggctgtgct gatgtaccat   1440

taataattta agccagtggt tcttggcagg tgatcccaag acctgcagct tcagcatcac   1500

ttgagaagtt gttaggaatg catactagtg ggccccgccc ccagacatag tgaatcagaa   1560

accaacaggg aggcgcctag cattgttttt ttaacaagtg ctgggttatt ctgatgcaca   1620

gtctagttta agaaccacta ctttgggtaa acgttttgac tgtttaaagt ttatggcggt   1680

gaagtgggcg tcttcaaaga ctagtactta cacagtttag aagatttcaa ggtactgctg   1740

acagtagttt attatgtcag tatacataca tgtgtagaga tcataattta gttcccttct   1800

taatgttaca atttcttagt ttacttttcc taaagggcca tagcataatt cttgattcct   1860

ggtggaaatc ttttctgagg tgtgggggtg ggcaaggtgt ggattgctgt ttacgatagt   1920

gccttcatta gttttagttc tgtctgtttt cattcattat tgactcaaag gtattagaac   1980

aggcccttat ctttttccta ttagatttat ttttgttttt tactttatgt aagttcagaa   2040

tcctttttta agtgatgact actgatgaaa taatgttact agtagctgaa ttttagactt   2100

gatgctatgt tgattaatat ttaaatggtg aaagtaatta ggcaaaataa gcaattctgc   2160

ttttctgttg ctttcagaat ttttaggctg taaaattgtc tcaggcagga agtcagtcta   2220

tatctctctc aagttcttat tgtaggtcat ttttttttca gcacagctct aatttttaaa   2280

tatttggtat aacagcttct ggcatgtgac ctagttaatg ttgaaaatta actgatgaaa   2340

acccttgtag atctgctaaa cttctctata aattgctaga aatatacaga gcaatgagat   2400

atagaaaaca ccttagcttg ttggttatta atagagctct aattttaact gtgaaatcat   2460

ggagtttctt taaatgtttt cctagagtgt tcgttatcat gaacattaga aatagcatta   2520

ttccttttct tctaccacat gtcttgaaca ttcacatggg ttaaagaaga tggaaactga   2580

tactactgac aatcaagctg ctttctgact ttcataattt tctttatatt gtggatagca   2640

ttttgaaggt gaccgtgatt ctgtaggaag agctgtaatc aatatttttc aaactctaag   2700

agtacagagg ttagtaagat ttcttttttt ttactttttg ttacgtcaag tagcttatta   2760

agaaaaagat tcatgactta aactcttaat tctcagttga tacaaaggct tataatcatg   2820

tgttttaaaa ttttgatttc attttcgttc cttgaaggtt aaagaatgga aactggggat   2880

aaaaattaat acactgcagc tttgccaagg tctgtgatat ggttgtaacc ttttaaagac   2940

tactaaagtc ataatttgaa atttttacta aaataaaaca tatgtgtcta tggttttcaa   3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      3028


<210>  120
<211>  388
<212>  PRT
<213>  Homosapiens

<400>  120

Met Ser Asp Glu Ala Ser Ala Ile Thr Ser Tyr Glu Lys Phe Leu Thr 
1               5                   10                  15      


Pro Glu Glu Pro Phe Pro Leu Leu Gly Pro Pro Arg Gly Val Gly Thr 
            20                  25                  30          


Cys Pro Ser Glu Glu Pro Gly Cys Leu Asp Ile Ser Asp Phe Gly Cys 
        35                  40                  45              


Gln Leu Ser Ser Cys His Arg Thr Asp Pro Leu His Arg Phe His Thr 
    50                  55                  60                  


Asn Arg Trp Asn Leu Thr Ser Cys Gly Thr Ser Val Ala Ser Ser Glu 
65                  70                  75                  80  


Gly Ser Glu Glu Leu Phe Ser Ser Val Ser Val Gly Asp Gln Asp Asp 
                85                  90                  95      


Cys Tyr Ser Leu Leu Asp Asp Gln Asp Phe Thr Ser Phe Asp Leu Phe 
            100                 105                 110         


Pro Glu Gly Ser Val Cys Ser Asp Val Ser Ser Ser Ile Ser Thr Tyr 
        115                 120                 125             


Trp Asp Trp Ser Asp Ser Glu Phe Glu Trp Gln Leu Pro Gly Ser Asp 
    130                 135                 140                 


Ile Ala Ser Gly Ser Asp Val Leu Ser Asp Val Ile Pro Ser Ile Pro 
145                 150                 155                 160 


Ser Ser Pro Cys Leu Leu Pro Lys Lys Lys Asn Lys His Arg Asn Leu 
                165                 170                 175     


Asp Glu Leu Pro Trp Ser Ala Met Thr Asn Asp Glu Gln Val Glu Tyr 
            180                 185                 190         


Ile Glu Tyr Leu Ser Arg Lys Val Ser Thr Glu Met Gly Leu Arg Glu 
        195                 200                 205             


Gln Leu Asp Ile Ile Lys Ile Ile Asp Pro Ser Ala Gln Ile Ser Pro 
    210                 215                 220                 


Thr Asp Ser Glu Phe Ile Ile Glu Leu Asn Cys Leu Thr Asp Glu Lys 
225                 230                 235                 240 


Leu Lys Gln Val Arg Asn Tyr Ile Lys Glu His Ser Pro Arg Gln Arg 
                245                 250                 255     


Pro Ala Arg Glu Ala Trp Lys Arg Ser Asn Phe Ser Cys Ala Ser Thr 
            260                 265                 270         


Ser Gly Val Ser Gly Ala Ser Ala Ser Ala Ser Ser Ser Ser Ala Ser 
        275                 280                 285             


Met Val Ser Ser Ala Ser Ser Ser Gly Ser Ser Val Gly Asn Ser Ala 
    290                 295                 300                 


Ser Asn Ser Ser Ala Asn Met Ser Arg Ala His Ser Asp Ser Asn Leu 
305                 310                 315                 320 


Ser Ala Ser Ala Ala Glu Arg Ile Arg Asp Ser Lys Lys Arg Ser Lys 
                325                 330                 335     


Gln Arg Lys Leu Gln Gln Lys Ala Phe Arg Lys Arg Gln Leu Lys Glu 
            340                 345                 350         


Gln Arg Gln Ala Arg Lys Glu Arg Leu Ser Gly Leu Phe Leu Asn Glu 
        355                 360                 365             


Glu Val Leu Ser Leu Lys Val Thr Glu Glu Asp His Glu Ala Asp Val 
    370                 375                 380                 


Asp Val Leu Met 
385             


<210>  121
<211>  3306
<212>  DNA
<213>  Homosapiens

<400>  121
ccaatatcaa gaagctgctg acatcctgga tctagggttg taaagaagat tacatgagct     60

aatggatgtg aaaacatctt aaaaactctc aaatactttt caactttgga ggattattat    120

gattttcatt ctgttcagcg gctatactca gactttactc taaaagtcaa atcttctgac    180

attctttgaa gtgaagcatt ctatgaatgt gagctgaaga aatgaatgaa atgaaataat    240

gcagcatcta gtgctttttg catggcccaa aggggctctg tgctgctcca ctacagagga    300

aacttcaaga aatgctggtt tgctacagtg ttttagcttg tgagattctc tgggaccttc    360

cctgctccat catggggtca cctctaggtc attttacctg ggacaaatac ctaaaagaaa    420

catgttcagt cccagcgcct gtccattgct tcaagcagtc ctacacacct ccaagcaacg    480

agttcaagat cagtatgaaa ttggaagcac aggaccccag gaacaccaca tccacctgta    540

ttgccacagt agttggactg acaggtgccc gccttcgcct gcgccttgat gggagcgaca    600

acaaaaatga cttctggcgg ctggttgact cagctgaaat ccagcctatt gggaactgtg    660

aaaagaatgg gggtatgcta cagccacctc ttggatttcg gctgaatgcg tcttcttggc    720

ccatgttcct tttgaagacg ctaaatggag cagagatggc tcccatcagg attttccaca    780

aggagccacc atcgccttcc cacaacttct tcaaaatggg aatgaagcta gaagctgtgg    840

acaggaagaa ccctcatttc atttgcccag ccactattgg ggaggttcgg ggctcagagg    900

tgcttgtcac ttttgatggg tggcgagggg cctttgacta ctggtgccgc ttcgactccc    960

gagacatctt ccctgtgggc tggtgttcct tgactggaga caacctgcag cctcctggca   1020

ccaaagttgt gattccaaag aatccctatc ctgcctccga tgtgaatact gagaagccca   1080

gcatccacag cagcaccaaa actgtcttgg aacatcaacc agggcagagg gggcgtaaac   1140

caggaaagaa gcggggccgg acacccaaga ccctaatttc ccatcccatc tctgccccat   1200

ccaagacagc tgaacctttg aaattcccaa agaagagagg tcccaaacct ggcagcaaga   1260

ggaaacctcg gactttgctg aacccaccac ctgcctcacc aacaaccagc actcctgaac   1320

cggataccag cactgtaccc caggatgctg ccaccatccc cagctcagcc atgcaggccc   1380

caacagtttg tatctacttg aacaagaatg gcagcacagg cccccactta gataagaaga   1440

aggtccagca actccctgac cattttggac cagcccgtgc ctctgtggtg ttgcagcagg   1500

ctgtccaggc ctgtatcgac tgtgcttatc accagaaaac cgtcttcagc ttcctcaagc   1560

aaggccatgg tggtgaggtt atctcagccg tgtttgaccg ggaacagcat accctcaacc   1620

tcccagcagt caacagcatc acctacgtcc tccgcttcct ggagaaactc tgccacaacc   1680

ttcgtagtga caatctgttt ggcaaccagc cctttacaca gactcacttg tcactcactg   1740

ccatagagta cagccacagc cacgacaggt acctaccagg tgaaaccttt gtcctgggga   1800

atagtctggc ccgctccttg gaaccacact cagactcaat ggactctgcc tcaaatccca   1860

ccaaccttgt cagcacctcc caaaggcacc ggcccttgct ttcatcctgt ggcctcccac   1920

caagcactgc ctcagctgtg cgcaggctat gctccagggg agtgttaaaa ggatcaaatg   1980

aaagaaggga tatggaatca ttttggaaac taaatcgttc cccagggtcg gaccgatacc   2040

tggagagccg cgatgcctct cgactgagtg gccgggaccc ctcctcatgg acagtcgagg   2100

atgtgatgca gtttgtccgg gaagctgatc ctcagcttgg accccacgct gacctgtttc   2160

gcaaacacga gatcgatggc aaggccctgc tgctgctgcg cagtgacatg atgatgaagt   2220

acatgggcct gaagctgggg cctgcactca agctctccta ccacattgac cggctgaagc   2280

agggcaagtt ctgaaccagg agaggcagcc tagacaacca agtggcagca ggtgggggca   2340

ttcttctagg aatgaggggc atcagcccac cccaggcacc tcagtggggt tccgggccac   2400

ctcaggactc taagaggctg tgtggagcca ccactcctag ccacagctgc catgataagt   2460

ccttccatga aggactgagg agggagagtg ggggtccagg gctggtgctg ctcttccctc   2520

agctctgccg gggctctaag gtccctctat ttatttctca accctggctg gcctctcacc   2580

aggagtttag gctgaatgcc ttccacgtga tggaggaaaa ggccaactct gtcctggtct   2640

tgctgtggca ccccatcgcc ccacagctcg taccttctca ccagattccc ctgaatccaa   2700

actcgtggtg caaacctcta ccttttttac aaaaagatct tattgttaat ttattgtttc   2760

tggcacttgg gcaaaccctg tagttaatac tcctcccaca ctagacactg ggtttcagga   2820

ggagggagac tgccctgctt tggtcccaga gaggccctct gcagataggc gtggcccctc   2880

ttcagaggac actaccctag ggcactttct ctttgaggtg gagagaccca taaagccttg   2940

accacatcac tccatatggg gaggagaagg atccctgtca ccttctcctc tcttcacggg   3000

gcccttttgc agccctaggc ctcatctgtg ggaagggagt ccctggctca tactgccccc   3060

accacagctc cttgccctgg ccagaactgc tgtcgaagaa aatcaggccg gaaggccaag   3120

aaggcgctaa gggggatggg agggcaggtt ttccaggctg gagtcggttc cacccactcg   3180

cctgtccaca ggcttccttg taagcaagtc agcagcacag ctactcacgc tgccatctgg   3240

acttatttta tgtcaatctg tttataaata aaaaccaata tagataaaaa aaaaaaaaaa   3300

aaaaaa                                                              3306


<210>  122
<211>  660
<212>  PRT
<213>  Homosapiens

<400>  122

Met Leu Val Cys Tyr Ser Val Leu Ala Cys Glu Ile Leu Trp Asp Leu 
1               5                   10                  15      


Pro Cys Ser Ile Met Gly Ser Pro Leu Gly His Phe Thr Trp Asp Lys 
            20                  25                  30          


Tyr Leu Lys Glu Thr Cys Ser Val Pro Ala Pro Val His Cys Phe Lys 
        35                  40                  45              


Gln Ser Tyr Thr Pro Pro Ser Asn Glu Phe Lys Ile Ser Met Lys Leu 
    50                  55                  60                  


Glu Ala Gln Asp Pro Arg Asn Thr Thr Ser Thr Cys Ile Ala Thr Val 
65                  70                  75                  80  


Val Gly Leu Thr Gly Ala Arg Leu Arg Leu Arg Leu Asp Gly Ser Asp 
                85                  90                  95      


Asn Lys Asn Asp Phe Trp Arg Leu Val Asp Ser Ala Glu Ile Gln Pro 
            100                 105                 110         


Ile Gly Asn Cys Glu Lys Asn Gly Gly Met Leu Gln Pro Pro Leu Gly 
        115                 120                 125             


Phe Arg Leu Asn Ala Ser Ser Trp Pro Met Phe Leu Leu Lys Thr Leu 
    130                 135                 140                 


Asn Gly Ala Glu Met Ala Pro Ile Arg Ile Phe His Lys Glu Pro Pro 
145                 150                 155                 160 


Ser Pro Ser His Asn Phe Phe Lys Met Gly Met Lys Leu Glu Ala Val 
                165                 170                 175     


Asp Arg Lys Asn Pro His Phe Ile Cys Pro Ala Thr Ile Gly Glu Val 
            180                 185                 190         


Arg Gly Ser Glu Val Leu Val Thr Phe Asp Gly Trp Arg Gly Ala Phe 
        195                 200                 205             


Asp Tyr Trp Cys Arg Phe Asp Ser Arg Asp Ile Phe Pro Val Gly Trp 
    210                 215                 220                 


Cys Ser Leu Thr Gly Asp Asn Leu Gln Pro Pro Gly Thr Lys Val Val 
225                 230                 235                 240 


Ile Pro Lys Asn Pro Tyr Pro Ala Ser Asp Val Asn Thr Glu Lys Pro 
                245                 250                 255     


Ser Ile His Ser Ser Thr Lys Thr Val Leu Glu His Gln Pro Gly Gln 
            260                 265                 270         


Arg Gly Arg Lys Pro Gly Lys Lys Arg Gly Arg Thr Pro Lys Thr Leu 
        275                 280                 285             


Ile Ser His Pro Ile Ser Ala Pro Ser Lys Thr Ala Glu Pro Leu Lys 
    290                 295                 300                 


Phe Pro Lys Lys Arg Gly Pro Lys Pro Gly Ser Lys Arg Lys Pro Arg 
305                 310                 315                 320 


Thr Leu Leu Asn Pro Pro Pro Ala Ser Pro Thr Thr Ser Thr Pro Glu 
                325                 330                 335     


Pro Asp Thr Ser Thr Val Pro Gln Asp Ala Ala Thr Ile Pro Ser Ser 
            340                 345                 350         


Ala Met Gln Ala Pro Thr Val Cys Ile Tyr Leu Asn Lys Asn Gly Ser 
        355                 360                 365             


Thr Gly Pro His Leu Asp Lys Lys Lys Val Gln Gln Leu Pro Asp His 
    370                 375                 380                 


Phe Gly Pro Ala Arg Ala Ser Val Val Leu Gln Gln Ala Val Gln Ala 
385                 390                 395                 400 


Cys Ile Asp Cys Ala Tyr His Gln Lys Thr Val Phe Ser Phe Leu Lys 
                405                 410                 415     


Gln Gly His Gly Gly Glu Val Ile Ser Ala Val Phe Asp Arg Glu Gln 
            420                 425                 430         


His Thr Leu Asn Leu Pro Ala Val Asn Ser Ile Thr Tyr Val Leu Arg 
        435                 440                 445             


Phe Leu Glu Lys Leu Cys His Asn Leu Arg Ser Asp Asn Leu Phe Gly 
    450                 455                 460                 


Asn Gln Pro Phe Thr Gln Thr His Leu Ser Leu Thr Ala Ile Glu Tyr 
465                 470                 475                 480 


Ser His Ser His Asp Arg Tyr Leu Pro Gly Glu Thr Phe Val Leu Gly 
                485                 490                 495     


Asn Ser Leu Ala Arg Ser Leu Glu Pro His Ser Asp Ser Met Asp Ser 
            500                 505                 510         


Ala Ser Asn Pro Thr Asn Leu Val Ser Thr Ser Gln Arg His Arg Pro 
        515                 520                 525             


Leu Leu Ser Ser Cys Gly Leu Pro Pro Ser Thr Ala Ser Ala Val Arg 
    530                 535                 540                 


Arg Leu Cys Ser Arg Gly Val Leu Lys Gly Ser Asn Glu Arg Arg Asp 
545                 550                 555                 560 


Met Glu Ser Phe Trp Lys Leu Asn Arg Ser Pro Gly Ser Asp Arg Tyr 
                565                 570                 575     


Leu Glu Ser Arg Asp Ala Ser Arg Leu Ser Gly Arg Asp Pro Ser Ser 
            580                 585                 590         


Trp Thr Val Glu Asp Val Met Gln Phe Val Arg Glu Ala Asp Pro Gln 
        595                 600                 605             


Leu Gly Pro His Ala Asp Leu Phe Arg Lys His Glu Ile Asp Gly Lys 
    610                 615                 620                 


Ala Leu Leu Leu Leu Arg Ser Asp Met Met Met Lys Tyr Met Gly Leu 
625                 630                 635                 640 


Lys Leu Gly Pro Ala Leu Lys Leu Ser Tyr His Ile Asp Arg Leu Lys 
                645                 650                 655     


Gln Gly Lys Phe 
            660 


<210>  123
<211>  3250
<212>  DNA
<213>  Homosapiens

<400>  123
gcggaaacat ggcggcggga agggagtgag ccgccccgcg cccccgccgc gccctcagat     60

ggagaaatta gcatacaaag aaactgactt gtcagaagtc agagcaaggt attggtggat    120

ccagggataa atcccaaact tcttaacccc tagaccggtt tttagtccat tgactatgca    180

gcctaatgtg atagactgga gtgatgttag aaaacacaaa tatggtcacc tatcagagtc    240

tgcatcccaa tatcaagaag ctgctgacat cctggatcta gggttgtaaa gaagattaca    300

tgagctaatg gatgtgaaaa catcttaaaa actctcaaat acttttcaac tttggaggat    360

tattatgatt ttcattctgt tcagcggcca tactcagact ttactctaaa agtcaaatct    420

tctgacattc tttgaagtga agcattctat gaatgtgagc tgaagaaatg aatgaaatga    480

aataatgcag tcctacacac ctccaagcaa cgagttcaag atcagtatga aattggaagc    540

acaggacccc aggaacacca catccacctg tattgccaca gtagttggac tgacaggtgc    600

ccgccttcgc ctgcgccttg atgggagcga caacaaaaat gacttctggc ggctggttga    660

ctcagctgaa atccagccta ttgggaactg tgaaaagaat gggggtatgc tacagccacc    720

tcttggattt cggctgaatg cgtcttcttg gcccatgttc cttttgaaga cgctaaatgg    780

agcagagatg gctcccatca ggattttcca caaggagcca ccatcgcctt cccacaactt    840

cttcaaaatg ggaatgaagc tagaagctgt ggacaggaag aaccctcatt tcatttgccc    900

agccactatt ggggaggttc ggggctcaga ggtgcttgtc acttttgatg ggtggcgagg    960

ggcctttgac tactggtgcc gcttcgactc ccgagacatc ttccctgtgg gctggtgttc   1020

cttgactgga gacaacctgc agcctcctgg caccaaagtt gtgattccaa agaatcccta   1080

tcctgcctcc gatgtgaata ctgagaagcc cagcatccac agcagcacca aaactgtctt   1140

ggaacatcaa ccagggcaga gggggcgtaa accaggaaag aagcggggcc ggacacccaa   1200

gaccctaatt tcccatccca tctctgcccc atccaagaca gctgaacctt tgaaattccc   1260

aaagaagaga ggtcccaaac ctggcagcaa gaggaaacct cggactttgc tgaacccacc   1320

acctgcctca ccaacaacca gcactcctga accggatacc agcactgtac cccaggatgc   1380

tgccaccatc cccagctcag ccatgcaggc cccaacagtt tgtatctact tgaacaagaa   1440

tggcagcaca ggcccccact tagataagaa gaaggtccag caactccctg accattttgg   1500

accagcccgt gcctctgtgg tgttgcagca ggctgtccag gcctgtatcg actgtgctta   1560

tcaccagaaa accgtcttca gcttcctcaa gcaaggccat ggtggtgagg ttatctcagc   1620

cgtgtttgac cgggaacagc ataccctcaa cctcccagca gtcaacagca tcacctacgt   1680

cctccgcttc ctggagaaac tctgccacaa ccttcgtagt gacaatctgt ttggcaacca   1740

gccctttaca cagactcact tgtcactcac tgccatagag tacagccaca gccacgacag   1800

gtacctacca ggtgaaacct ttgtcctggg gaatagtctg gcccgctcct tggaaccaca   1860

ctcagactca atggactctg cctcaaatcc caccaacctt gtcagcacct cccaaaggca   1920

ccggcccttg ctttcatcct gtggcctccc accaagcact gcctcagctg tgcgcaggct   1980

atgctccagg gggtcggacc gatacctgga gagccgcgat gcctctcgac tgagtggccg   2040

ggacccctcc tcgtggacag tcgaggatgt gatgcagttt gtccgggaag ctgatcctca   2100

gcttggaccc cacgctgacc tgtttcgcaa acacgagatc gatggcaagg ccctgctgct   2160

gctgcgcagt gacatgatga tgaagtacat gggcctgaag ctggggcctg cactcaagct   2220

ctcctaccac attgaccggc tgaagcaggg caagttctga accaggagag gcagcctaga   2280

caaccaagtg gcagcaggtg ggggcattct tctaagaatg aggggcatca gcccacccca   2340

ggcacctcag tggggttccg ggccacctca ggactccaag aggctgtgtg gagccaccac   2400

tcctagccac agctgccatg ataagtcctt ccatgaagga ctgaggaggg agagtggggg   2460

tccagggctg gtgctgctct tccctcagct ctgccggggc tctaaggtcc ctctatttat   2520

ttctcaaccc tggctggcct ctcaccagga gtttaggctg aatgccttcc acgtgatgga   2580

ggaaaaggcc aactctgtcc tggtcttgct gtggcacccc atcgccccac agctcgtacc   2640

ttctcaccag attcccctga atccaaactc gtggtgcaaa cctctacctt ttttacaaaa   2700

agatcttatt gttaatttat tgtttctggc acttgggcaa accctgtagt taatactcct   2760

cccacactag acactgggtt tcaggaggag ggagactgcc ctgctttggt cccagagagg   2820

ccctctgcag ataggcgtgg cccctcttca gaggacacta ccctagggca ctttctcttt   2880

gaggtggaga gacccataaa gccttgacca catcactcca tatggggagg agaaggatcc   2940

ctgtcacctt ctcctctctt cacggggccc ttttgcagcc ctaggcctca tctgtgggaa   3000

gggagtccct ggctcatact gcccccacca cagctccttg ccctggccag aactgctgtc   3060

gaagaaaatc aggccggaag gccaagaagg cgctaagggg gatgggaggg caggttttcc   3120

aggctggagt cggttccacc cactcgcctg tccacaggct tccttgtaag caagtcagca   3180

gcacagctac tcacgctgcc atctggactt attttatgtc aatctgttta taaataaaaa   3240

ccaatatagg                                                          3250


<210>  124
<211>  591
<212>  PRT
<213>  Homosapiens

<400>  124

Met Gln Ser Tyr Thr Pro Pro Ser Asn Glu Phe Lys Ile Ser Met Lys 
1               5                   10                  15      


Leu Glu Ala Gln Asp Pro Arg Asn Thr Thr Ser Thr Cys Ile Ala Thr 
            20                  25                  30          


Val Val Gly Leu Thr Gly Ala Arg Leu Arg Leu Arg Leu Asp Gly Ser 
        35                  40                  45              


Asp Asn Lys Asn Asp Phe Trp Arg Leu Val Asp Ser Ala Glu Ile Gln 
    50                  55                  60                  


Pro Ile Gly Asn Cys Glu Lys Asn Gly Gly Met Leu Gln Pro Pro Leu 
65                  70                  75                  80  


Gly Phe Arg Leu Asn Ala Ser Ser Trp Pro Met Phe Leu Leu Lys Thr 
                85                  90                  95      


Leu Asn Gly Ala Glu Met Ala Pro Ile Arg Ile Phe His Lys Glu Pro 
            100                 105                 110         


Pro Ser Pro Ser His Asn Phe Phe Lys Met Gly Met Lys Leu Glu Ala 
        115                 120                 125             


Val Asp Arg Lys Asn Pro His Phe Ile Cys Pro Ala Thr Ile Gly Glu 
    130                 135                 140                 


Val Arg Gly Ser Glu Val Leu Val Thr Phe Asp Gly Trp Arg Gly Ala 
145                 150                 155                 160 


Phe Asp Tyr Trp Cys Arg Phe Asp Ser Arg Asp Ile Phe Pro Val Gly 
                165                 170                 175     


Trp Cys Ser Leu Thr Gly Asp Asn Leu Gln Pro Pro Gly Thr Lys Val 
            180                 185                 190         


Val Ile Pro Lys Asn Pro Tyr Pro Ala Ser Asp Val Asn Thr Glu Lys 
        195                 200                 205             


Pro Ser Ile His Ser Ser Thr Lys Thr Val Leu Glu His Gln Pro Gly 
    210                 215                 220                 


Gln Arg Gly Arg Lys Pro Gly Lys Lys Arg Gly Arg Thr Pro Lys Thr 
225                 230                 235                 240 


Leu Ile Ser His Pro Ile Ser Ala Pro Ser Lys Thr Ala Glu Pro Leu 
                245                 250                 255     


Lys Phe Pro Lys Lys Arg Gly Pro Lys Pro Gly Ser Lys Arg Lys Pro 
            260                 265                 270         


Arg Thr Leu Leu Asn Pro Pro Pro Ala Ser Pro Thr Thr Ser Thr Pro 
        275                 280                 285             


Glu Pro Asp Thr Ser Thr Val Pro Gln Asp Ala Ala Thr Ile Pro Ser 
    290                 295                 300                 


Ser Ala Met Gln Ala Pro Thr Val Cys Ile Tyr Leu Asn Lys Asn Gly 
305                 310                 315                 320 


Ser Thr Gly Pro His Leu Asp Lys Lys Lys Val Gln Gln Leu Pro Asp 
                325                 330                 335     


His Phe Gly Pro Ala Arg Ala Ser Val Val Leu Gln Gln Ala Val Gln 
            340                 345                 350         


Ala Cys Ile Asp Cys Ala Tyr His Gln Lys Thr Val Phe Ser Phe Leu 
        355                 360                 365             


Lys Gln Gly His Gly Gly Glu Val Ile Ser Ala Val Phe Asp Arg Glu 
    370                 375                 380                 


Gln His Thr Leu Asn Leu Pro Ala Val Asn Ser Ile Thr Tyr Val Leu 
385                 390                 395                 400 


Arg Phe Leu Glu Lys Leu Cys His Asn Leu Arg Ser Asp Asn Leu Phe 
                405                 410                 415     


Gly Asn Gln Pro Phe Thr Gln Thr His Leu Ser Leu Thr Ala Ile Glu 
            420                 425                 430         


Tyr Ser His Ser His Asp Arg Tyr Leu Pro Gly Glu Thr Phe Val Leu 
        435                 440                 445             


Gly Asn Ser Leu Ala Arg Ser Leu Glu Pro His Ser Asp Ser Met Asp 
    450                 455                 460                 


Ser Ala Ser Asn Pro Thr Asn Leu Val Ser Thr Ser Gln Arg His Arg 
465                 470                 475                 480 


Pro Leu Leu Ser Ser Cys Gly Leu Pro Pro Ser Thr Ala Ser Ala Val 
                485                 490                 495     


Arg Arg Leu Cys Ser Arg Gly Ser Asp Arg Tyr Leu Glu Ser Arg Asp 
            500                 505                 510         


Ala Ser Arg Leu Ser Gly Arg Asp Pro Ser Ser Trp Thr Val Glu Asp 
        515                 520                 525             


Val Met Gln Phe Val Arg Glu Ala Asp Pro Gln Leu Gly Pro His Ala 
    530                 535                 540                 


Asp Leu Phe Arg Lys His Glu Ile Asp Gly Lys Ala Leu Leu Leu Leu 
545                 550                 555                 560 


Arg Ser Asp Met Met Met Lys Tyr Met Gly Leu Lys Leu Gly Pro Ala 
                565                 570                 575     


Leu Lys Leu Ser Tyr His Ile Asp Arg Leu Lys Gln Gly Lys Phe 
            580                 585                 590     


<210>  125
<211>  684
<212>  DNA
<213>  Homosapiens

<400>  125
atgcagggcc gctgtggctc acttcggtgc ggggccgctc tccctgcccg tttccggcgg     60

ggcactgggg caggcggcac acgtgagtcg gccagccggg gcccagcccc caggacgctg    120

ctgacagctc cgggccctag gcgccccagc tctcggtggg ggccacgccg ccccgtcgac    180

ctctgtctct gccttccccg aaccgggacc cggccagcca gaatcacagg cattcccacc    240

tctggcgccg gaggggaccg actgacccgc gcagacgggg tcgcgccgcc gcccggccct    300

cggcccccag ccagcctgcc ccggcccacc cggccccgcc ggccagacac ggcgacctat    360

acggaccgcc cccacgccga ccctccaaag ggcccccggc cttgggtttc ccgtgccggg    420

gcccccgggc agtcctggcg gcgtcagggc cgcgaccgga ccgtgggccc cgcccgcccg    480

accgcagatg cagagccggc ctccgggctc ggggccgggc tgacacggcc gagaaagggc    540

ccagccccgc gcggaccaca gactggcagg ccggccagac agacggacag gctgaccccg    600

gcccggggga gcaggcgcag cggctgcgca ggtcccgcca ccgccttctg gccccaggcg    660

gcccctcagg gcacgagctc ttag                                           684


<210>  126
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  126

Met Gln Gly Arg Cys Gly Ser Leu Arg Cys Gly Ala Ala Leu Pro Ala 
1               5                   10                  15      


Arg Phe Arg Arg Gly Thr Gly Ala Gly Gly Thr Arg Glu Ser Ala Ser 
            20                  25                  30          


Arg Gly Pro Ala Pro Arg Thr Leu Leu Thr Ala Pro Gly Pro Arg Arg 
        35                  40                  45              


Pro Ser Ser Arg Trp Gly Pro Arg Arg Pro Val Asp Leu Cys Leu Cys 
    50                  55                  60                  


Leu Pro Arg Thr Gly Thr Arg Pro Ala Arg Ile Thr Gly Ile Pro Thr 
65                  70                  75                  80  


Ser Gly Ala Gly Gly Asp Arg Leu Thr Arg Ala Asp Gly Val Ala Pro 
                85                  90                  95      


Pro Pro Gly Pro Arg Pro Pro Ala Ser Leu Pro Arg Pro Thr Arg Pro 
            100                 105                 110         


Arg Arg Pro Asp Thr Ala Thr Tyr Thr Asp Arg Pro His Ala Asp Pro 
        115                 120                 125             


Pro Lys Gly Pro Arg Pro Trp Val Ser Arg Ala Gly Ala Pro Gly Gln 
    130                 135                 140                 


Ser Trp Arg Arg Gln Gly Arg Asp Arg Thr Val Gly Pro Ala Arg Pro 
145                 150                 155                 160 


Thr Ala Asp Ala Glu Pro Ala Ser Gly Leu Gly Ala Gly Leu Thr Arg 
                165                 170                 175     


Pro Arg Lys Gly Pro Ala Pro Arg Gly Pro Gln Thr Gly Arg Pro Ala 
            180                 185                 190         


Arg Gln Thr Asp Arg Leu Thr Pro Ala Arg Gly Ser Arg Arg Ser Gly 
        195                 200                 205             


Cys Ala Gly Pro Ala Thr Ala Phe Trp Pro Gln Ala Ala Pro Gln Gly 
    210                 215                 220                 


Thr Ser Ser 
225         


<210>  127
<211>  2118
<212>  DNA
<213>  Homosapiens

<400>  127
atggctgcga agctgcgagc gcatcaggtg gacgtggacc cggacttcgc gccgcagagc     60

cggccgcgct cgtgtacctg gcccctgccg cagcctgact tggccggcga cgaggacgga    120

gcgctgggcg caggggtggc cgagggcgcc gaggactgcg ggccggagcg ccgggctacg    180

gccccggcga tggccccagc gccgcccctg ggcgcggagg tcggaccgct gcggaaagcg    240

aagagctctc ggcggaacgc gtgggggaac ctgtcctacg ccgacctcat caccaaagcc    300

atcgagagcg ccccggacaa gcggctcacg ctctcgcaga tctacgactg gatggtccgt    360

tacgtgccct acttcaagga taaaggcgac agcaacagct cggccggctg gaaggtgggg    420

gcgtccggct ggggaggggg ctggggacgc cgactggggc ttccaggggc tgctaggtgt    480

gttgggctcc aggagggccg tcagaaggag ggctttttgg caccccccgg ggtcacagag    540

tcctgctcca gcagggctcc ctcctcctcc tttgtcctcc ggggatcccc agccccaagg    600

gctgatgggg gtggggaagt gactttccct gaggtcgcta cctgtgaagt agtggacctg    660

ggaattggac cccaagctcg agctttttct gttccattgg gagccagcct gcagggctgg    720

ggcacagctg ctgggccctc cccagagctg ggctcagggc agggctggct gcccttctat    780

cccttctcca ctgcagaccc tagtgccgag gatttgcaca tggcctcggg tccctggcat    840

catccaggtc acatcttttg ccaggaagag gcctggactg agaacctgaa cttcacccca    900

gatggcaggg caaatggtct ccctcgggcc ctgaatcagg gtctccagag aaccaggcag    960

ggcaaggctg gcaagtccca gctgttgcct tcaaaggcca gaaagtgcca gagacaggga   1020

gcctggggcc ctgaggagtc agatcagtgc ctggagctgg ggcagtacct ggaccaggaa   1080

gttgaggcca ccagaacagg cctggcaaaa gcaggcagtg acatggggag cactggagac   1140

tggcacagca gaattaaaaa gaggatgtat ggagagatgg cagagaactc catccggcac   1200

aacctgtcgc tgcacacccg tttcatccgc gtgcagaacg agggcaccgg caagagttcg   1260

tggtggatgc tgaaccccga gggcggaaag acagggaaga ccccgcggcg cagggccgtg   1320

tccatggaca acggggccaa gttcctgcgc atcaagggca aggcgagcaa gaagaagcag   1380

ctgcaggcgc ccgagcgaag cccggacgac agctccccga gtgcgcccgc cccggggccg   1440

gtgcctgccg cagccaagtg ggccgccagc cccgcctcgc acgccagcga cgactacgag   1500

gcttgggccg acttccgcgg cggcgggaga cccctgctcg gggaggcggc cgagctggag   1560

gacgacgagg ccctggaggc cctggcgcca tcatcgccgc tcatgtaccc aagccccgcc   1620

agcgcgctgt cgccggcgct gggctcgcgc tgtccgggtg agctgccccg cctggccgag   1680

ctgggaggcc cgctgggcct gcacggcggc ggcggcgcgg ggctgcccga gggcctgctg   1740

gacggcgcgc aggacgctgc cttagcccac cccatcagcc ttatgacgct gcccggcgag   1800

gcgggcgccg cgggcctggc accgccgggc cacgccgccg ccttcggggg cccgcccggc   1860

ggcctcctgc tggacgctct gccggggccc tacgctgccg ccgccgccgg gccgctgggc   1920

gccgcgcccg accgcttccc ggccgacctg gacctcgaca tgttcagcgg gagcctcgag   1980

tgcgacgtgg agtccatcat cctcaacgac ttcatggaca gcgacgaaat ggacttcaac   2040

ttcgattcgg ccctgcctcc gccgccgccg ggcctggccg gggccccgcc ccccaaccag   2100

agctgggtgc cgggctga                                                 2118


<210>  128
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  128

Met Ala Ala Lys Leu Arg Ala His Gln Val Asp Val Asp Pro Asp Phe 
1               5                   10                  15      


Ala Pro Gln Ser Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Gln Pro 
            20                  25                  30          


Asp Leu Ala Gly Asp Glu Asp Gly Ala Leu Gly Ala Gly Val Ala Glu 
        35                  40                  45              


Gly Ala Glu Asp Cys Gly Pro Glu Arg Arg Ala Thr Ala Pro Ala Met 
    50                  55                  60                  


Ala Pro Ala Pro Pro Leu Gly Ala Glu Val Gly Pro Leu Arg Lys Ala 
65                  70                  75                  80  


Lys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu Ser Tyr Ala Asp Leu 
                85                  90                  95      


Ile Thr Lys Ala Ile Glu Ser Ala Pro Asp Lys Arg Leu Thr Leu Ser 
            100                 105                 110         


Gln Ile Tyr Asp Trp Met Val Arg Tyr Val Pro Tyr Phe Lys Asp Lys 
        115                 120                 125             


Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Val Gly Ala Ser Gly Trp 
    130                 135                 140                 


Gly Gly Gly Trp Gly Arg Arg Leu Gly Leu Pro Gly Ala Ala Arg Cys 
145                 150                 155                 160 


Val Gly Leu Gln Glu Gly Arg Gln Lys Glu Gly Phe Leu Ala Pro Pro 
                165                 170                 175     


Gly Val Thr Glu Ser Cys Ser Ser Arg Ala Pro Ser Ser Ser Phe Val 
            180                 185                 190         


Leu Arg Gly Ser Pro Ala Pro Arg Ala Asp Gly Gly Gly Glu Val Thr 
        195                 200                 205             


Phe Pro Glu Val Ala Thr Cys Glu Val Val Asp Leu Gly Ile Gly Pro 
    210                 215                 220                 


Gln Ala Arg Ala Phe Ser Val Pro Leu Gly Ala Ser Leu Gln Gly Trp 
225                 230                 235                 240 


Gly Thr Ala Ala Gly Pro Ser Pro Glu Leu Gly Ser Gly Gln Gly Trp 
                245                 250                 255     


Leu Pro Phe Tyr Pro Phe Ser Thr Ala Asp Pro Ser Ala Glu Asp Leu 
            260                 265                 270         


His Met Ala Ser Gly Pro Trp His His Pro Gly His Ile Phe Cys Gln 
        275                 280                 285             


Glu Glu Ala Trp Thr Glu Asn Leu Asn Phe Thr Pro Asp Gly Arg Ala 
    290                 295                 300                 


Asn Gly Leu Pro Arg Ala Leu Asn Gln Gly Leu Gln Arg Thr Arg Gln 
305                 310                 315                 320 


Gly Lys Ala Gly Lys Ser Gln Leu Leu Pro Ser Lys Ala Arg Lys Cys 
                325                 330                 335     


Gln Arg Gln Gly Ala Trp Gly Pro Glu Glu Ser Asp Gln Cys Leu Glu 
            340                 345                 350         


Leu Gly Gln Tyr Leu Asp Gln Glu Val Glu Ala Thr Arg Thr Gly Leu 
        355                 360                 365             


Ala Lys Ala Gly Ser Asp Met Gly Ser Thr Gly Asp Trp His Ser Arg 
    370                 375                 380                 


Ile Lys Lys Arg Met Tyr Gly Glu Met Ala Glu Asn Ser Ile Arg His 
385                 390                 395                 400 


Asn Leu Ser Leu His Thr Arg Phe Ile Arg Val Gln Asn Glu Gly Thr 
                405                 410                 415     


Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Thr Gly 
            420                 425                 430         


Lys Thr Pro Arg Arg Arg Ala Val Ser Met Asp Asn Gly Ala Lys Phe 
        435                 440                 445             


Leu Arg Ile Lys Gly Lys Ala Ser Lys Lys Lys Gln Leu Gln Ala Pro 
    450                 455                 460                 


Glu Arg Ser Pro Asp Asp Ser Ser Pro Ser Ala Pro Ala Pro Gly Pro 
465                 470                 475                 480 


Val Pro Ala Ala Ala Lys Trp Ala Ala Ser Pro Ala Ser His Ala Ser 
                485                 490                 495     


Asp Asp Tyr Glu Ala Trp Ala Asp Phe Arg Gly Gly Gly Arg Pro Leu 
            500                 505                 510         


Leu Gly Glu Ala Ala Glu Leu Glu Asp Asp Glu Ala Leu Glu Ala Leu 
        515                 520                 525             


Ala Pro Ser Ser Pro Leu Met Tyr Pro Ser Pro Ala Ser Ala Leu Ser 
    530                 535                 540                 


Pro Ala Leu Gly Ser Arg Cys Pro Gly Glu Leu Pro Arg Leu Ala Glu 
545                 550                 555                 560 


Leu Gly Gly Pro Leu Gly Leu His Gly Gly Gly Gly Ala Gly Leu Pro 
                565                 570                 575     


Glu Gly Leu Leu Asp Gly Ala Gln Asp Ala Ala Leu Ala His Pro Ile 
            580                 585                 590         


Ser Leu Met Thr Leu Pro Gly Glu Ala Gly Ala Ala Gly Leu Ala Pro 
        595                 600                 605             


Pro Gly His Ala Ala Ala Phe Gly Gly Pro Pro Gly Gly Leu Leu Leu 
    610                 615                 620                 


Asp Ala Leu Pro Gly Pro Tyr Ala Ala Ala Ala Ala Gly Pro Leu Gly 
625                 630                 635                 640 


Ala Ala Pro Asp Arg Phe Pro Ala Asp Leu Asp Leu Asp Met Phe Ser 
                645                 650                 655     


Gly Ser Leu Glu Cys Asp Val Glu Ser Ile Ile Leu Asn Asp Phe Met 
            660                 665                 670         


Asp Ser Asp Glu Met Asp Phe Asn Phe Asp Ser Ala Leu Pro Pro Pro 
        675                 680                 685             


Pro Pro Gly Leu Ala Gly Ala Pro Pro Pro Asn Gln Ser Trp Val Pro 
    690                 695                 700                 


Gly 
705 


<210>  129
<211>  2438
<212>  DNA
<213>  Homosapiens

<400>  129
cgaagaggat ccggagcagc tgctgccagc ccgcgggcac tgaagtcctc ccggctgccg     60

ctcgagtagc cacgggcgcg atcgggacca gaagtctcct cctccatgat cactttggaa    120

gccgggggaa gactttgccc tgccctgaga gctggtctgc gtttcccagg cgcggcggcg    180

gcggagcagc agctgcagca gccgagtcca aataggagcg gccacagcca ggggcgtgtg    240

cgccccgcgc ggagcgagct cgggttcccc tcggaatgtc cccggggcgc ccggcgcgct    300

gaccccgaag ccgcctccgc cttcggcgcc tgctgcctcc ctcggccagg cttgttgttc    360

gggactgtga gcttcctggc tcctgggcag tggggaagcc cccgggggcg agtgacctca    420

gctggccacg acccagccct cccccgtgcg tatctcgctt aagatggcag cggagtcagg    480

ggaactaatc ggggcttgtg agttcatgaa agatcggtta tattttgcta ctttaaggaa    540

tagaccaaaa agcacagtaa atacccacta tttctccatc gatgaggagc tggtctatga    600

aaatttctat gcagattttg gaccgctgaa cttggcaatg gtgtacagat attgctgcaa    660

actaaacaag aaactaaaat catacagttt gtcaagaaag aaaatagtgc actacacctg    720

ttttgaccaa cggaaaagag caaatgcagc atttttgata ggtgcctatg cagtaatcta    780

tttaaagaag acaccagaag aagcctacag agcactcctg tctggctcaa acccccccta    840

tcttccattc agggatgctt cctttggaaa ttgcacttac aatctcacca ttctcgactg    900

tttgcaggga atcagaaagg gattacaaca tggatttttt gactttgaga catttgatgt    960

ggatgaatat gaacattatg agcgagttga aaatggtgac ttcaactgga ttgttccagg   1020

aaaattttta gcatttagtg gaccacatcc taaaagcaaa attgagaatg gttatcctct   1080

tcacgcccct gaagcctact ttccttattt caaaaagcat aatgtgactg cagttgtgag   1140

gctaaacaaa aagatttatg aggcaaagcg cttcacagac gctggcttcg agcactatga   1200

cctcttcttc atagatggca gcacacccag tgacaacatc gtgcgaaggt tcctgaacat   1260

ctgtgagaac accgaagggg ccatcgccgt tcactgcaaa gctggtcttg gaagaacagg   1320

gacattgata gcctgttatg taatgaaaca ctacaggttt acacatgctg aaataattgc   1380

ttggattaga atatgccggc caggctctat tataggaccc cagcagcact tcctggaaga   1440

aaaacaagca tcgttgtggg tccaaggaga cattttccga tccaaactga aaaatcgacc   1500

atccagtgaa ggaagtatta ataaaattct ttctggccta gatgatatgt ctattggtgg   1560

aaatctttca aaaacacaaa acatggaacg atttggagag gataacttag aagatgatga   1620

tgtggaaatg aaaaatggta taacccaggg agacaaacta cgtgccttaa aaagtcagag   1680

acagccacgt acctcaccat cctgtgcatt taggtcagat gatacaaaag gacatccaag   1740

agcagtgtcc cagcctttca gattaagttc atccctgcaa ggatctgcag ttactttgaa   1800

gacatcaaaa atggcactgt ccccttcagc aacggccaag aggatcaaca gaacttcttt   1860

gtcttcgggt gccactgtaa gaagcttttc cataaactcc cggctagcca gttctctagg   1920

gaacttgaat gctgcaacag atgatccaga gaacaaaaag acctcctcat cctctaaggc   1980

aggcttcaca gccagcccgt ttaccaacct cttgaatggc agctcccagc caactaccag   2040

aaattaccct gagctcaaca ataatcagta caacagaagc agcaacagca acgggggcaa   2100

cctgaacagc cccccaggcc cccacagcgc caagacagag gagcacacca ccatcctccg   2160

accctcctac accgggcttt cttcttcttc agcgagattc ctgagccgtt ctatccctgt   2220

aagtgcgcag acaccacctc ctggtcctca gaaccctgaa tgcaacttct gtgccttgcc   2280

ttcccagccg aggctgccac caaagaaatt taatagtgcc aaggaagcct tctgagcgat   2340

gccttccctc tgtgctgtga aactgtctat gcactacatt ctgctagctc ctcttcaagt   2400

aaacgccaag tcacaaaaaa aaaaaaaaaa aaaaaaaa                           2438


<210>  130
<211>  623
<212>  PRT
<213>  Homosapiens

<400>  130

Met Ala Ala Glu Ser Gly Glu Leu Ile Gly Ala Cys Glu Phe Met Lys 
1               5                   10                  15      


Asp Arg Leu Tyr Phe Ala Thr Leu Arg Asn Arg Pro Lys Ser Thr Val 
            20                  25                  30          


Asn Thr His Tyr Phe Ser Ile Asp Glu Glu Leu Val Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Leu Asn Lys Lys Leu Lys Ser Tyr Ser Leu Ser Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Tyr Thr Cys Phe Asp Gln Arg Lys Arg Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Ile Gly Ala Tyr Ala Val Ile Tyr Leu Lys Lys Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ala Leu Leu Ser Gly Ser Asn Pro Pro Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asp Ala Ser Phe Gly Asn Cys Thr Tyr Asn Leu Thr Ile Leu 
    130                 135                 140                 


Asp Cys Leu Gln Gly Ile Arg Lys Gly Leu Gln His Gly Phe Phe Asp 
145                 150                 155                 160 


Phe Glu Thr Phe Asp Val Asp Glu Tyr Glu His Tyr Glu Arg Val Glu 
                165                 170                 175     


Asn Gly Asp Phe Asn Trp Ile Val Pro Gly Lys Phe Leu Ala Phe Ser 
            180                 185                 190         


Gly Pro His Pro Lys Ser Lys Ile Glu Asn Gly Tyr Pro Leu His Ala 
        195                 200                 205             


Pro Glu Ala Tyr Phe Pro Tyr Phe Lys Lys His Asn Val Thr Ala Val 
    210                 215                 220                 


Val Arg Leu Asn Lys Lys Ile Tyr Glu Ala Lys Arg Phe Thr Asp Ala 
225                 230                 235                 240 


Gly Phe Glu His Tyr Asp Leu Phe Phe Ile Asp Gly Ser Thr Pro Ser 
                245                 250                 255     


Asp Asn Ile Val Arg Arg Phe Leu Asn Ile Cys Glu Asn Thr Glu Gly 
            260                 265                 270         


Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu 
        275                 280                 285             


Ile Ala Cys Tyr Val Met Lys His Tyr Arg Phe Thr His Ala Glu Ile 
    290                 295                 300                 


Ile Ala Trp Ile Arg Ile Cys Arg Pro Gly Ser Ile Ile Gly Pro Gln 
305                 310                 315                 320 


Gln His Phe Leu Glu Glu Lys Gln Ala Ser Leu Trp Val Gln Gly Asp 
                325                 330                 335     


Ile Phe Arg Ser Lys Leu Lys Asn Arg Pro Ser Ser Glu Gly Ser Ile 
            340                 345                 350         


Asn Lys Ile Leu Ser Gly Leu Asp Asp Met Ser Ile Gly Gly Asn Leu 
        355                 360                 365             


Ser Lys Thr Gln Asn Met Glu Arg Phe Gly Glu Asp Asn Leu Glu Asp 
    370                 375                 380                 


Asp Asp Val Glu Met Lys Asn Gly Ile Thr Gln Gly Asp Lys Leu Arg 
385                 390                 395                 400 


Ala Leu Lys Ser Gln Arg Gln Pro Arg Thr Ser Pro Ser Cys Ala Phe 
                405                 410                 415     


Arg Ser Asp Asp Thr Lys Gly His Pro Arg Ala Val Ser Gln Pro Phe 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Gln Gly Ser Ala Val Thr Leu Lys Thr Ser 
        435                 440                 445             


Lys Met Ala Leu Ser Pro Ser Ala Thr Ala Lys Arg Ile Asn Arg Thr 
    450                 455                 460                 


Ser Leu Ser Ser Gly Ala Thr Val Arg Ser Phe Ser Ile Asn Ser Arg 
465                 470                 475                 480 


Leu Ala Ser Ser Leu Gly Asn Leu Asn Ala Ala Thr Asp Asp Pro Glu 
                485                 490                 495     


Asn Lys Lys Thr Ser Ser Ser Ser Lys Ala Gly Phe Thr Ala Ser Pro 
            500                 505                 510         


Phe Thr Asn Leu Leu Asn Gly Ser Ser Gln Pro Thr Thr Arg Asn Tyr 
        515                 520                 525             


Pro Glu Leu Asn Asn Asn Gln Tyr Asn Arg Ser Ser Asn Ser Asn Gly 
    530                 535                 540                 


Gly Asn Leu Asn Ser Pro Pro Gly Pro His Ser Ala Lys Thr Glu Glu 
545                 550                 555                 560 


His Thr Thr Ile Leu Arg Pro Ser Tyr Thr Gly Leu Ser Ser Ser Ser 
                565                 570                 575     


Ala Arg Phe Leu Ser Arg Ser Ile Pro Val Ser Ala Gln Thr Pro Pro 
            580                 585                 590         


Pro Gly Pro Gln Asn Pro Glu Cys Asn Phe Cys Ala Leu Pro Ser Gln 
        595                 600                 605             


Pro Arg Leu Pro Pro Lys Lys Phe Asn Ser Ala Lys Glu Ala Phe 
    610                 615                 620             


<210>  131
<211>  1900
<212>  DNA
<213>  Homosapiens

<400>  131
cgaagaggat ccggagcagc tgctgccagc ccgcgggcac tgaagtcctc ccggctgccg     60

ctcgagtagc cacgggcgcg atcgggacca gaagtctcct cctccatgat cactttggaa    120

gccgggggaa gactttgccc tgccctgaga gctggtctgc gtttcccagg cgcggcggcg    180

gcggagcagc agctgcagca gccgagtcca aataggagcg gccacagcca ggggcgtgtg    240

cgccccgcgc ggagcgagct cgggttcccc tcggaatgtc cccggggcgc ccggcgcgct    300

gaccccgaag ccgcctccgc cttcggcgcc tgctgcctcc ctcggccagg cttgttgttc    360

gggactgtga gcttcctggc tcctgggcag tggggaagcc cccgggggcg agtgacctca    420

gctggccacg acccagccct cccccgtgcg tatctcgctt aagatggcag cggagtcagg    480

ggaactaatc ggggcttgtg agttcatgaa agatcggtta tattttgcta ctttaaggaa    540

tagaccaaaa agcacagtaa atacccacta tttctccatc gatgaggagc tggtctatga    600

aaatttctat gcagattttg gaccgctgaa cttggcaatg gtgtacagat attgctgcaa    660

actaaacaag aaactaaaat catacagttt gtcaagaaag aaaatagtgc actacacctg    720

ttttgaccaa cggaaaagag caaatgcagc atttttgata ggtgcctatg cagtaatcta    780

tttaaagaag acaccagaag aagcctacag agcactcctg tctggctcaa acccccccta    840

tcttccattc agggatgctt cctttggaaa ttgcacttac aatctcacca ttctcgactg    900

tttgcaggga atcagaaagg gattacaaca tggatttttt gactttgaga catttgatgt    960

ggatgaatat gaacattatg agcgagttga aaatggtgac ttcaactgga ttgttccagg   1020

aaaattttta gcatttagtg gaccacatcc taaaagcaaa attgagaatg gttatcctct   1080

tcacgcccct gaagcctact ttccttattt caaaaagcat aatgtgactg cagttgtgag   1140

gctaaacaaa aagatttatg aggcaaagcg cttcacagac gctggcttcg agcactatga   1200

cctcttcttc atagatggca gcacacccag tgacaacatc gtgcgaaggt tcctgaacat   1260

ctgtgagaac accgaagggg ccatcgccgt tcactgcaaa gctggtcttg gaagaacagg   1320

gacattgata gcctgttatg taatgaaaca ctacaggttt acacatgctg aaataattgc   1380

ttggattaga atatgccggc caggctctat tataggaccc cagcagcact tcctggaaga   1440

aaaacaagca tcgttgtggg tccaaggaga cattttccga tccaaactga aaaatcgacc   1500

atccagtgaa ggaagtatta ataaaattct ttctggccta gatgatatgt ctattggtgg   1560

aaatctttca aaaacacaaa acatggaacg atttggagag gtaagttttc cctaggagat   1620

tctatcttct taaaactgat gttctgcatt tgtttctcag ttggacctat ataacatagc   1680

agtgtctttt ctctggatgc cacgagtacc aagtttttag aagtagagcc atccgtctat   1740

atagcaagaa gcagaggaaa gaaaccaatt gcccttaaaa aaaaaaagct ataatttaag   1800

gagtaaatta taaaggaggc tactctggta aggggtaata tttatagaaa ggaaacagaa   1860

aagcaaactt tctatttgaa aaaaaaaaaa aaaaaaaaaa                         1900


<210>  132
<211>  383
<212>  PRT
<213>  Homosapiens

<400>  132

Met Ala Ala Glu Ser Gly Glu Leu Ile Gly Ala Cys Glu Phe Met Lys 
1               5                   10                  15      


Asp Arg Leu Tyr Phe Ala Thr Leu Arg Asn Arg Pro Lys Ser Thr Val 
            20                  25                  30          


Asn Thr His Tyr Phe Ser Ile Asp Glu Glu Leu Val Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Leu Asn Lys Lys Leu Lys Ser Tyr Ser Leu Ser Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Tyr Thr Cys Phe Asp Gln Arg Lys Arg Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Ile Gly Ala Tyr Ala Val Ile Tyr Leu Lys Lys Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ala Leu Leu Ser Gly Ser Asn Pro Pro Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asp Ala Ser Phe Gly Asn Cys Thr Tyr Asn Leu Thr Ile Leu 
    130                 135                 140                 


Asp Cys Leu Gln Gly Ile Arg Lys Gly Leu Gln His Gly Phe Phe Asp 
145                 150                 155                 160 


Phe Glu Thr Phe Asp Val Asp Glu Tyr Glu His Tyr Glu Arg Val Glu 
                165                 170                 175     


Asn Gly Asp Phe Asn Trp Ile Val Pro Gly Lys Phe Leu Ala Phe Ser 
            180                 185                 190         


Gly Pro His Pro Lys Ser Lys Ile Glu Asn Gly Tyr Pro Leu His Ala 
        195                 200                 205             


Pro Glu Ala Tyr Phe Pro Tyr Phe Lys Lys His Asn Val Thr Ala Val 
    210                 215                 220                 


Val Arg Leu Asn Lys Lys Ile Tyr Glu Ala Lys Arg Phe Thr Asp Ala 
225                 230                 235                 240 


Gly Phe Glu His Tyr Asp Leu Phe Phe Ile Asp Gly Ser Thr Pro Ser 
                245                 250                 255     


Asp Asn Ile Val Arg Arg Phe Leu Asn Ile Cys Glu Asn Thr Glu Gly 
            260                 265                 270         


Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu 
        275                 280                 285             


Ile Ala Cys Tyr Val Met Lys His Tyr Arg Phe Thr His Ala Glu Ile 
    290                 295                 300                 


Ile Ala Trp Ile Arg Ile Cys Arg Pro Gly Ser Ile Ile Gly Pro Gln 
305                 310                 315                 320 


Gln His Phe Leu Glu Glu Lys Gln Ala Ser Leu Trp Val Gln Gly Asp 
                325                 330                 335     


Ile Phe Arg Ser Lys Leu Lys Asn Arg Pro Ser Ser Glu Gly Ser Ile 
            340                 345                 350         


Asn Lys Ile Leu Ser Gly Leu Asp Asp Met Ser Ile Gly Gly Asn Leu 
        355                 360                 365             


Ser Lys Thr Gln Asn Met Glu Arg Phe Gly Glu Val Ser Phe Pro 
    370                 375                 380             


<210>  133
<211>  4262
<212>  DNA
<213>  Homosapiens

<400>  133
cgaagaggat ccggagcagc tgctgccagc ccgcgggcac tgaagtcctc ccggctgccg     60

ctcgagtagc cacgggcgcg atcgggacca gaagtctcct cctccatgat cactttggaa    120

gccggggggg aagactttgc cctgccctga gagctggtct gcgtttccca ggcgcggcgg    180

cggcggagca gcagctgcag cagccgagtc caaataggag cggccacagc caggggcgtg    240

tgcgccccgc gcggagcgag ctcgggttcc cctcggaatg tccccggggc gcccggcgcg    300

ctgaccccga agccgcctcc gccttcggcg cctgctgcct ccctcggcca ggcttgttgt    360

tcgggactgt gagcttcctg gctcctgggc agtggggaag cccccggggg cgagtgacct    420

cagctggcca cgacccagcc ctcccccgtg cgtatctcgc ttaagatggc agcggagtca    480

ggggaactaa tcggggcttg tgagttcatg aaagatcggt tatattttgc tactttaagg    540

aatagaccaa aaagcacagt aaatacccac tatttctcca tcgatgagga gctggtctat    600

gaaaatttct atgcagattt tggaccgctg aacttggcaa tggtgtacag atattgctgc    660

aaactaaaca agaaactaaa atcatacagt ttgtcaagaa agaaaatagt gcactacacc    720

tgttttgacc aacggaaaag agcaaatgca gcatttttga taggtgccta tgcagtaatc    780

tatttaaaga agacaccaga agaagcctac agagcactcc tgtctggctc aaaccccccc    840

tatcttccat tcagggatgc ttcctttgga aattgcactt acaatctcac cattctcgac    900

tgtttgcagg gaatcagaaa gggattacaa catggatttt ttgactttga gacatttgat    960

gtggatgaat atgaacatta tgagcgagtt gaaaatggtg acttcaactg gattgttcca   1020

ggaaaatttt tagcatttag tggaccacat cctaaaagca aaattgagaa tggttatcct   1080

cttcacgccc ctgaagccta ctttccttat ttcaaaaagc ataatgtgac tgcagttgtg   1140

aggctaaaca aaaagattta tgaggcaaag cgcttcacag acgctggctt cgagcactat   1200

gacctcttct tcatagatgg cagcacaccc agtgacaaca tcgtgcgaag gttcctgaac   1260

atctgtgaga acaccgaagg ggccatcgcc gttcactgca aagctggtct tggaagaaca   1320

gggacattga tagcctgtta tgtaatgaaa cactacaggt ttacacatgc tgaaataatt   1380

gcttggatta gaatatgccg gccaggctct attataggac cccagcagca cttcctggaa   1440

gaaaaacaag catcgttgtg ggtccaagga gacattttcc gatccaaact gaaaaatcga   1500

ccatccagtg aaggaagtat taataaaatt ctttctggcc tagatgatat gtctattggt   1560

ggaaatcttt caaaaacaca aaacatggaa cgatttggag aggataactt agaagatgat   1620

gatgtggaaa tgaaaaatgg tataacccag ggagacaaac tacgtgcctt aaaaagtcag   1680

agacagccac gtacctcacc atcctgtgca tttaggtcag atgatacaaa aggacatcca   1740

agagcagtgt cccagccttt cagattaagt tcatccctgc aaggatctgc agttactttg   1800

aagacatcaa aaatggcact gtccccttca gcaacggcca agaggatcaa cagaacttct   1860

ttgtcttcgg gtgccactgt aagaagcttt tccataaact cccggctagc cagttctcta   1920

gggaacttga atgctgcaac agatgatcca gagaacaaaa agacctcctc atcctctaag   1980

gcaggcttca cagccagccc gtttaccaac ctcttgaatg gcagctccca gccaactacc   2040

agaaattacc ctgagctcaa caataatcag tacaacagaa gcagcaacag caacgggggc   2100

aacctgaaca gccccccagg cccccacagc gccaagacag aggagcacac caccatcctc   2160

cgaccctcct acaccgggct ttcttcttct tcagcgagat tcctgagccg ttctatccct   2220

tcccttcagt ctgaatatgt tcattactaa ggccttgcca ctccagtgaa agctgttctt   2280

ctcttagaca caatttcttc atctggacga gcagtggaga gggaaagcaa cttcttgctg   2340

gaagaatatc tctgccttct taccttaaat taaaaagagc actaagataa caccttcaag   2400

agacttgaaa acagaaaact ggttaatgac tactataaat gcactgaaac tatgttatgg   2460

agatttccat acttttaaag acagttttaa tgttgaattt ggtattttga agggttattt   2520

ttaatgtatt ttggtaatac atttattatt atatttacat gtacagtgtt acattatata   2580

tgtattgtga actttaaaag actattttga taaatttata aatatataaa attatgtaaa   2640

aactacacta tattttgatt tagattttcc tgctgtttgc taccaaaaat ttgtatttta   2700

aatctgttta gttttagtat ggttttgtct ctaatgaata aataattcct tcttattaag   2760

aagaagtaag ggagaaagtt tttagaaagt gatttttatg ctcgcactat aaatatggca   2820

ggtcagttca ttcttttggg aagtcagttt agttacactg agtttatcca agtttatctc   2880

taccaagagt ataatggcat gggatggctt atttaggaca attccctttc ctattgtttt   2940

tgttgctgag ccaatttgag ttagttttgc atcctggggg gctttaaaat acagcatgca   3000

gtgaaagatc agaattcact gaatatttct tctgagagca tggtttcatg gtttttctct   3060

atgaaatgac tcaatattcc aaatgttttt ttttccttcc tcctttcaaa agagttctta   3120

acccaattag gatatcctgc tttgggtatg aggttgttgt tgcctgtaat cacacatggt   3180

ttgacatcag ttttaaatca atggagagaa aaaactgaaa aagatgctgc taagtagttc   3240

tctgtattaa aggagatatt tttaaaacag ggtacaaccc cctgctgcac acgctagcat   3300

atctggaacc tactatgaaa atgaaaggac ccttataggt actcacagcc ctttcatgta   3360

agtatgatct gatatttagg tcttcagaag cctgtaggtt tcatttctat gaggaatcga   3420

ggagcgttac atcctgatat ccttccaggc tgcttaagaa tggactgctt cgacactgaa   3480

agtgctagtt aaatggattc atatgaagtg ctttactccc aaccattgag ttatttataa   3540

tgtatttatt aggggagggt accttgagtc tattatatat gcttcatcaa aacatcttgt   3600

tcatgtttta tgtttttaaa aaaggcattt gaatgaatgt ttgactcagg tttgttaaat   3660

taacttcagt aactgcagta ccaaaaatta cactcaactg atgaaaaaaa cgaattgtat   3720

gatttaggaa tcaaaaacta aaataagtgg aattatgtat cttttctaaa gttaaaaaag   3780

taaaatattt tattatgagt tattataaaa attggttaat tgtataggaa gatgacagta   3840

tttttttcaa gttatcataa aaagtaattc agatgacatt tgagaagtag gggaaaggga   3900

atcatgttga cagttttagt tctgtgaaca ctaatttgtg tgaagctatt aaaatgattg   3960

taaagttgac tactgtaaat ttcccataat tatgtgtgta tatgtgtcat atgtatgtac   4020

atgtatatgt ctaaaaatta ctttacacat gtgcctacat agacacacca agaagtggat   4080

gtatataata tagaaagtat atagcaaagt aattttactc tgataataaa aattgtttga   4140

catgtatttt gttatgaata gtttatcttc caaaagatat tttgctctat tttaaagtgt   4200

agaagaatac actgctaata aataataaaa gttttattca atttaaaaaa aaaaaaaaaa   4260

aa                                                                  4262


<210>  134
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  134

Met Ala Ala Glu Ser Gly Glu Leu Ile Gly Ala Cys Glu Phe Met Lys 
1               5                   10                  15      


Asp Arg Leu Tyr Phe Ala Thr Leu Arg Asn Arg Pro Lys Ser Thr Val 
            20                  25                  30          


Asn Thr His Tyr Phe Ser Ile Asp Glu Glu Leu Val Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Leu Asn Lys Lys Leu Lys Ser Tyr Ser Leu Ser Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Tyr Thr Cys Phe Asp Gln Arg Lys Arg Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Ile Gly Ala Tyr Ala Val Ile Tyr Leu Lys Lys Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ala Leu Leu Ser Gly Ser Asn Pro Pro Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asp Ala Ser Phe Gly Asn Cys Thr Tyr Asn Leu Thr Ile Leu 
    130                 135                 140                 


Asp Cys Leu Gln Gly Ile Arg Lys Gly Leu Gln His Gly Phe Phe Asp 
145                 150                 155                 160 


Phe Glu Thr Phe Asp Val Asp Glu Tyr Glu His Tyr Glu Arg Val Glu 
                165                 170                 175     


Asn Gly Asp Phe Asn Trp Ile Val Pro Gly Lys Phe Leu Ala Phe Ser 
            180                 185                 190         


Gly Pro His Pro Lys Ser Lys Ile Glu Asn Gly Tyr Pro Leu His Ala 
        195                 200                 205             


Pro Glu Ala Tyr Phe Pro Tyr Phe Lys Lys His Asn Val Thr Ala Val 
    210                 215                 220                 


Val Arg Leu Asn Lys Lys Ile Tyr Glu Ala Lys Arg Phe Thr Asp Ala 
225                 230                 235                 240 


Gly Phe Glu His Tyr Asp Leu Phe Phe Ile Asp Gly Ser Thr Pro Ser 
                245                 250                 255     


Asp Asn Ile Val Arg Arg Phe Leu Asn Ile Cys Glu Asn Thr Glu Gly 
            260                 265                 270         


Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu 
        275                 280                 285             


Ile Ala Cys Tyr Val Met Lys His Tyr Arg Phe Thr His Ala Glu Ile 
    290                 295                 300                 


Ile Ala Trp Ile Arg Ile Cys Arg Pro Gly Ser Ile Ile Gly Pro Gln 
305                 310                 315                 320 


Gln His Phe Leu Glu Glu Lys Gln Ala Ser Leu Trp Val Gln Gly Asp 
                325                 330                 335     


Ile Phe Arg Ser Lys Leu Lys Asn Arg Pro Ser Ser Glu Gly Ser Ile 
            340                 345                 350         


Asn Lys Ile Leu Ser Gly Leu Asp Asp Met Ser Ile Gly Gly Asn Leu 
        355                 360                 365             


Ser Lys Thr Gln Asn Met Glu Arg Phe Gly Glu Asp Asn Leu Glu Asp 
    370                 375                 380                 


Asp Asp Val Glu Met Lys Asn Gly Ile Thr Gln Gly Asp Lys Leu Arg 
385                 390                 395                 400 


Ala Leu Lys Ser Gln Arg Gln Pro Arg Thr Ser Pro Ser Cys Ala Phe 
                405                 410                 415     


Arg Ser Asp Asp Thr Lys Gly His Pro Arg Ala Val Ser Gln Pro Phe 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Gln Gly Ser Ala Val Thr Leu Lys Thr Ser 
        435                 440                 445             


Lys Met Ala Leu Ser Pro Ser Ala Thr Ala Lys Arg Ile Asn Arg Thr 
    450                 455                 460                 


Ser Leu Ser Ser Gly Ala Thr Val Arg Ser Phe Ser Ile Asn Ser Arg 
465                 470                 475                 480 


Leu Ala Ser Ser Leu Gly Asn Leu Asn Ala Ala Thr Asp Asp Pro Glu 
                485                 490                 495     


Asn Lys Lys Thr Ser Ser Ser Ser Lys Ala Gly Phe Thr Ala Ser Pro 
            500                 505                 510         


Phe Thr Asn Leu Leu Asn Gly Ser Ser Gln Pro Thr Thr Arg Asn Tyr 
        515                 520                 525             


Pro Glu Leu Asn Asn Asn Gln Tyr Asn Arg Ser Ser Asn Ser Asn Gly 
    530                 535                 540                 


Gly Asn Leu Asn Ser Pro Pro Gly Pro His Ser Ala Lys Thr Glu Glu 
545                 550                 555                 560 


His Thr Thr Ile Leu Arg Pro Ser Tyr Thr Gly Leu Ser Ser Ser Ser 
                565                 570                 575     


Ala Arg Phe Leu Ser Arg Ser Ile Pro Ser Leu Gln Ser Glu Tyr Val 
            580                 585                 590         


His Tyr 
        


<210>  135
<211>  3517
<212>  DNA
<213>  Homosapiens

<400>  135
gggttccaca tcagccacca ctcctgcttc tgagcacagg gtgctctcct cttgagctca     60

gcttctgatt ttgcagccaa gcattcttgc tgctgctgcc tgcctgccca cccgcctggg    120

cttgcagccc gccactttac tttctccagc cctgatacca gctgagaagt ctccctgcag    180

ctgctagttc ctgcccagga ccatgtgtgt ggatgctgct tgggagaagc gggcacttgc    240

tcctggcact gatcccagct gagtttctcc tgttgatttc tggaccactg atgctgttgc    300

tgaggaggta tttcctggca tccctccccc tgagacaccg gctaaggacc agcctaaacg    360

caaggcagga cagtgtcagg atggaccgcg ctgccagaag ccgacgctag cgagggaggt    420

gtgaagagtt ggccagaatg accaactcct cctccacatc cacctcctcc accaccggtg    480

gctcgctgct gctgctctgc gaggaagagg agtcgtgggc gggccggcgc atcccggtgt    540

cactcctgta ttcgggcctg gccatcgggg gcacgctggc caacggcatg gtcatctatc    600

tcgtgtcgtc cttccgaaag ctgcagacca ccagcaacgc cttcattgtg aacggctgcg    660

ccgccgacct cagcgtctgc gccctctgga tgccgcagga ggcggtgctc gggctcctgc    720

ccaccggctc tgcggagccc cccgcagact gggacggcgc tgggggcagc taccgcctgc    780

tacggggtgg gctgctgggc ctcggactca cggtgtccct cctctcccac tgcctcgtgg    840

ccctgaaccg ctacctgctc atcacccggg cgcccgccac ctaccaggcg ctgtaccaga    900

ggcgccacac ggcgggcatg ctggcgctgt cctgggcgct cgccctgggc ctcgtgctgc    960

tgctcccgcc ctgggcaccg cggcccggcg ccgcgccacc gcgaatccac tacccggcgc   1020

tgctggccgc cgcggcgctg ctggcgcaga cagctctgct gctgcactgc tacctgggca   1080

tcgtgcgccg cgtgcgtgtc agcgtcaagc gggtcagcgt gctcaacttc cacctgctgc   1140

accagttgcc cggctgcgcc gccgccgccg ccgccttccc gggcgcccag cacgcgccgg   1200

gccccggtgg cgccgcgcac ccggcgcagg cccagcccct gccgcccgcg ctgcacccgc   1260

ggcgggcaca gcggcgtctc agcggcctgt cggtgctgct gctctgctgc gtcttcctgc   1320

tggccacgca gccactggtg tgggtgagcc tggccagcgg cttctcgctg ccggtgccct   1380

ggggagtgca cgcggccagc tggctcctgt gctgcgccct gtccgcgctc aacccgctgc   1440

tctacacgtg gaggaacgag gagttccgcc gctccgtgcg ctcagtcctg ccgggcgtcg   1500

gcgacgcggc ggccgctgcc gttgccgcca cagccgtgcc cgcagtgtcc caggcgcaac   1560

tgggcacccg cgccgcgggc cagcactggt aacctagccg gggcccgagg gaagcggaga   1620

tccccggctt ccgacgtcct tgggcaccgt cgcctccttc cctcctaggg catcccctgc   1680

ctgaacgaag acttccgccg cgaagcccga tagatcgggg gaaaatgggg ccttcgaccc   1740

cagcgggcta cctgaaccaa ggcgtctctc taagtggggc gcccgaagtc attttggacg   1800

gccacctgat ttttaccctt tgtttctgtg ttttagagga atcctaaagt caaaacacca   1860

gagacttgaa gaacttgcaa actggcgttt taaaataacc ggttaattta tttccacaca   1920

gtttgttttt gaaaaagagc tttcataatg tataaccctt tccactttca tcgtcttata   1980

tatgaagcgc cttgagtgtg catgaaccaa aggaaataac attgaagaag gaaaacaata   2040

tgtagaaagt attttagaaa gtaacctgtc tttgatgatg cttctcttac catttagttt   2100

ttgtatatta ccctggggca gtgaagccct aggtgtgccc accagtatga gttgccatta   2160

agacctcaag ccctttattc ttaaaagggt ttttaataaa gtctttctca aatgaggtag   2220

aatcttagcc agtgagaaaa aaaattattt tatgctcctt ttttttcgca ctcttaagac   2280

tgaaaattgg cgttgagtgt tatagtgaaa attttccagt ttgataattg atggtcagag   2340

ccagcactgg aattttgaaa acaaataagg tgattatcta ttttaggtac cgtttcacat   2400

tttctatagc atgcacactt gttgctaccc tcattttgta accaatttat ttgccttatg   2460

aatgtgattg cagctttgaa cattctgtac tgtaatggtt gctaagaaga ataagtcctt   2520

ctgttttctc tttaacattt aaaatatctc aatgcacatg atataattaa acactaataa   2580

taccatgact gcatagctaa tattagctgc tattgcatgc tcctagatgc tagaacttat   2640

tgggcatgtg gtatactgaa gcgatacccg ttagacaagg atattttact tcttccagac   2700

accagaagaa atggccttca attatttgaa aagagacaca gagacacctc tggctaccta   2760

gagttcttcc tgtcttgacc aatttatgag aaagctccca gttgggactt tatctcacaa   2820

gtggaatcac agtcaagacg gatcaataat atggttggct cagcaaagcc agctgtgctc   2880

ttttagggtt taaacaagcc acacgttaga aagcaacact gtttttatgt agttcatata   2940

tattaccacg acatttaaca tcaatattgt atatgttgaa ggaggtataa taaactcagt   3000

catatatagt gaacagttca aatgggaaag tgttctaaaa catattattt gaggtttgtc   3060

atattcatct ttggtttact aaatttactt agaaatattt gaaatgcaaa attgtgtgaa   3120

atcaccttat caaattaaaa tgggaagaaa gtaattttaa taatttttaa taatcatatg   3180

tcagcattct gactacttac cacatcaaat ctgggcccaa acagcctcag ttaactgcat   3240

aattcaggaa caaaaccagc ttgctttgtt gcacgcctgg gcaatttcag ccaggacatt   3300

aggaccactt gttgtacatc tgaataatta tggaagttgg gacatgttaa ggaaaacaaa   3360

tatgttcatc accaacaatc agctgtcatt ttattaatct atcccttttg tgcatgcacc   3420

atttctctct tactaacagt ttcatctgtt cacattttcc ttgattcaaa tattaaagtt   3480

cagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            3517


<210>  136
<211>  384
<212>  PRT
<213>  Homosapiens

<400>  136

Met Thr Asn Ser Ser Ser Thr Ser Thr Ser Ser Thr Thr Gly Gly Ser 
1               5                   10                  15      


Leu Leu Leu Leu Cys Glu Glu Glu Glu Ser Trp Ala Gly Arg Arg Ile 
            20                  25                  30          


Pro Val Ser Leu Leu Tyr Ser Gly Leu Ala Ile Gly Gly Thr Leu Ala 
        35                  40                  45              


Asn Gly Met Val Ile Tyr Leu Val Ser Ser Phe Arg Lys Leu Gln Thr 
    50                  55                  60                  


Thr Ser Asn Ala Phe Ile Val Asn Gly Cys Ala Ala Asp Leu Ser Val 
65                  70                  75                  80  


Cys Ala Leu Trp Met Pro Gln Glu Ala Val Leu Gly Leu Leu Pro Thr 
                85                  90                  95      


Gly Ser Ala Glu Pro Pro Ala Asp Trp Asp Gly Ala Gly Gly Ser Tyr 
            100                 105                 110         


Arg Leu Leu Arg Gly Gly Leu Leu Gly Leu Gly Leu Thr Val Ser Leu 
        115                 120                 125             


Leu Ser His Cys Leu Val Ala Leu Asn Arg Tyr Leu Leu Ile Thr Arg 
    130                 135                 140                 


Ala Pro Ala Thr Tyr Gln Ala Leu Tyr Gln Arg Arg His Thr Ala Gly 
145                 150                 155                 160 


Met Leu Ala Leu Ser Trp Ala Leu Ala Leu Gly Leu Val Leu Leu Leu 
                165                 170                 175     


Pro Pro Trp Ala Pro Arg Pro Gly Ala Ala Pro Pro Arg Ile His Tyr 
            180                 185                 190         


Pro Ala Leu Leu Ala Ala Ala Ala Leu Leu Ala Gln Thr Ala Leu Leu 
        195                 200                 205             


Leu His Cys Tyr Leu Gly Ile Val Arg Arg Val Arg Val Ser Val Lys 
    210                 215                 220                 


Arg Val Ser Val Leu Asn Phe His Leu Leu His Gln Leu Pro Gly Cys 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Phe Pro Gly Ala Gln His Ala Pro Gly Pro 
                245                 250                 255     


Gly Gly Ala Ala His Pro Ala Gln Ala Gln Pro Leu Pro Pro Ala Leu 
            260                 265                 270         


His Pro Arg Arg Ala Gln Arg Arg Leu Ser Gly Leu Ser Val Leu Leu 
        275                 280                 285             


Leu Cys Cys Val Phe Leu Leu Ala Thr Gln Pro Leu Val Trp Val Ser 
    290                 295                 300                 


Leu Ala Ser Gly Phe Ser Leu Pro Val Pro Trp Gly Val His Ala Ala 
305                 310                 315                 320 


Ser Trp Leu Leu Cys Cys Ala Leu Ser Ala Leu Asn Pro Leu Leu Tyr 
                325                 330                 335     


Thr Trp Arg Asn Glu Glu Phe Arg Arg Ser Val Arg Ser Val Leu Pro 
            340                 345                 350         


Gly Val Gly Asp Ala Ala Ala Ala Ala Val Ala Ala Thr Ala Val Pro 
        355                 360                 365             


Ala Val Ser Gln Ala Gln Leu Gly Thr Arg Ala Ala Gly Gln His Trp 
    370                 375                 380                 


<210>  137
<211>  3898
<212>  DNA
<213>  Homosapiens

<400>  137
gaggcttcgg tgcagagctg gagagccgcg gctgggaccg gagtggggag cgcggcgtgg     60

aggtgccacc cggcgcgggt ggcggagaga tcagaagcct cttccccaag ccgagccaac    120

ctcagcgggg acccgggctc agggacgcgg cggcggcggc ggcgactgca gtggctggac    180

gatggcagcg tccgccggag ccggggcggt gattgcagcc ccagacagcc ggcgctggct    240

gtggtcggtg ctggcggcgg cgcttgggct cttgacagct ggagtatcag ccttggaagt    300

atatacgcca aaagaaatct tcgtggcaaa tggtacacaa gggaagctga cctgcaagtt    360

caagtctact agtacgactg gcgggttgac ctcagtctcc tggagcttcc agccagaggg    420

ggccgacact actgtgtcgt ttttccacta ctcccaaggg caagtgtacc ttgggaatta    480

tccaccattt aaagacagaa tcagctgggc tggagacctt gacaagaaag atgcatcaat    540

caacatagaa aatatgcagt ttatacacaa tggcacctat atctgtgatg tcaaaaaccc    600

tcctgacatc gttgtccagc ctggacacat taggctctat gtcgtagaaa aagagaattt    660

gcctgtgttt ccagtttggg tagtggtggg catagttact gctgtggtcc taggtctcac    720

tctgctcatc agcatgattc tggctgtcct ctatagaagg aaaaactcta aacgggatta    780

cactggctgc agtacatcag agagtttgtc accagttaag caggctcctc ggaagtcccc    840

ctccgacact gagggtcttg taaagagtct gccttctgga tctcaccagg gcccagtcat    900

atatgcacag ttagaccact ccggcggaca tcacagtgac aagattaaca agtcagagtc    960

tgtggtgtat gcggatatcc gaaagaatta agagaatacc tagaacatat cctcagcaag   1020

aaacaaaacc aaactggact ctcgtgcaga aaatgtagcc cattaccaca tgtagccttg   1080

gagacccagg caaggacaag tacacgtgta ctcacagagg gagagaaaga tgtgtacaaa   1140

ggatatgtat aaatattcta tttagtcatc ctgatatgag gagccagtgt tgcatgatga   1200

aaagatggta tgattctaca tatgtaccca ttgtcttgct gtttttgtac tttcttttca   1260

ggtcatttac aattgggaga tttcagaaac attcctttca ccatcattta gaaatggttt   1320

gccttaatgg agacaatagc agatcctgta gtatttccag tagacatggc cttttaatct   1380

aagggcttaa gactgattag tcttagcatt tactgtagtt ggaggatgga gatgctatga   1440

tggaagcata cccagggtgg cctttagcac agtatcagta ccatttattt gtctgccgct   1500

tttaaaaaat acccattggc tatgccactt gaaaacaatt tgagaagttt ttttgaagtt   1560

tttctcacta aaatatgggg caattgttag ccttacatgt tgtgtagact tactttaagt   1620

ttgcaccctt gaaatgtgtc atatcaattt ctggattcat aatagcaaga ttagcaaagg   1680

ataaatgccg aaggtcactt cattctggac acagttggat caatactgat taagtagaaa   1740

atccaagctt tgcttgagaa cttttgtaac gtggagagta aaaagtatcg gttttattct   1800

ttgctgatgt cctttctgct tgaaataaca gtcaccatac agctaaagga gaggagtttc   1860

tttccttcta agtaggcaga aatggtatca ttatgttgcc gctctccaat ctcccagagc   1920

tcgctctcta gagaatcacc ttctttcgct tttttttttt tttttgaggt agagtctcac   1980

tatgttgccc agactagcct tgaactcttg ggctcaagtg attctccctc ctcagcctcc   2040

cgagtagctg gaacgaacta tagttgcacc actgcagctg gcaagaatca ccttctttat   2100

aaagcgtcag tcatgcttcc agcaagaggc agcatcagtc atggctttat aacagcttca   2160

tggtgcctca aagactgttg aggttaatga gagcctagat tagacagttt ggctgtcctt   2220

ccctaaaact tgttttctcc tattcactac tccccaccgc acttaaaatc tatgagtttt   2280

tactttttac tgggaatgga aagtgtggtg aagatcattc aacacttatg ttgtcatttc   2340

tcccattttc tgaatttttt tttaaatttc ccccctttta aaattgttcg aaagcccaca   2400

gttatggaaa gaattactgt ctagatggtc tgcagaacgt gtttggggtg agtgggagtg   2460

aggggcaatg ttactttttc tccctgtagt ttggagtcca ttatgagctg ctgctttttc   2520

ttctcatctt gtcatcttct ggggatgttt gaaggctgag ttccaacaga attcacaaag   2580

ggaataaaac aggattgaga ttttgaggtg tgcacaaggt ggtaagataa agggcatatg   2640

agcttcaaaa ctaatgctgt tgcatacatg aagccttttg ttttttgagg agctattttt   2700

gttattcttg taacgctcca ccttacatgc cacatctgtg tgagtcaaca gggatcaggt   2760

ttggtcacca cacatgtctg aagctgggca gcgtctgctc tgtgttctgt gtggaatgga   2820

gaaaaaaacg cctgccctgc tgccttccat gttcataggc ccagcccaag agagtgacac   2880

acagtgctgg ccctgagaca tttccacaaa gtggtcaact ctgccttgca tcctaaaact   2940

ttttgggcat ctattttgaa aactatagga gcctttggaa ggcctcttat gtttggaggg   3000

gaagggtgtt gagattgtca ccatccttca agctgagact cctggtgagc ctttgccacc   3060

atgaaaacca catagctgac cagggctgtg cttgaggtac agaggacaca cattgtagac   3120

aggcctgtgt catgtttcct tacagtcgtt ttttacagag aaaaggggca ttgttttttc   3180

actgctttct caacagttcc tgtgaataaa tgaaacattt cggagctccc tgagagcaag   3240

agccttcact tcttcttgcg gtgccgggac catgtgttgg tgaagctggt gctgtggggg   3300

ccactcactc gaatgacacc tggaggcctg ttcctccctt accactccct tccccagccc   3360

gacttcttgg cctcctgccc aaccagacac ctcaaactct gtcagtgccc tggcattctg   3420

gcagagaatc ctcaccagtt ctcaccaacc ttccccccag gcaagggcag ctgccagcat   3480

ggtgctctgc caggacaggt ttccctgaag gaagctgctc acactgagat gagcctctca   3540

gggcaggacc tcttcccaag ccctgcacac ccacccctgc agcccttttg gctccccttt   3600

tccctgtgcc tcagcactcc tttcctggtt gcagataacg aactaaggtt gcctaaaggg   3660

cagatctgcc ctctccatgt cttcgtcctg gcaaacaggg tcgtcttaaa attatgcgct   3720

aattctgtat gggagcactc aaaaggcatt acttagagat tgaaatttca aactatctct   3780

agtttttcaa tggaaatata tcagctaggg aaaaaccatc aagctcatta ttattttttg   3840

atcttcagtt gtatttttgt gaatatttta atacatcttt ttcaatttct gaaaaaaa     3898


<210>  138
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  138

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Cys Ser Thr Ser Glu Ser 
        195                 200                 205             


Leu Ser Pro Val Lys Gln Ala Pro Arg Lys Ser Pro Ser Asp Thr Glu 
    210                 215                 220                 


Gly Leu Val Lys Ser Leu Pro Ser Gly Ser His Gln Gly Pro Val Ile 
225                 230                 235                 240 


Tyr Ala Gln Leu Asp His Ser Gly Gly His His Ser Asp Lys Ile Asn 
                245                 250                 255     


Lys Ser Glu Ser Val Val Tyr Ala Asp Ile Arg Lys Asn 
            260                 265                 


<210>  139
<211>  3795
<212>  DNA
<213>  Homosapiens

<400>  139
gaggcttcgg tgcagagctg gagagccgcg gctgggaccg gagtggggag cgcggcgtgg     60

aggtgccacc cggcgcgggt ggcggagaga tcagaagcct cttccccaag ccgagccaac    120

ctcagcgggg acccgggctc agggacgcgg cggcggcggc ggcgactgca gtggctggac    180

gatggcagcg tccgccggag ccggggcggt gattgcagcc ccagacagcc ggcgctggct    240

gtggtcggtg ctggcggcgg cgcttgggct cttgacagct ggagtatcag ccttggaagt    300

atatacgcca aaagaaatct tcgtggcaaa tggtacacaa gggaagctga cctgcaagtt    360

caagtctact agtacgactg gcgggttgac ctcagtctcc tggagcttcc agccagaggg    420

ggccgacact actgtgtcgt ttttccacta ctcccaaggg caagtgtacc ttgggaatta    480

tccaccattt aaagacagaa tcagctgggc tggagacctt gacaagaaag atgcatcaat    540

caacatagaa aatatgcagt ttatacacaa tggcacctat atctgtgatg tcaaaaaccc    600

tcctgacatc gttgtccagc ctggacacat taggctctat gtcgtagaaa aagagaattt    660

gcctgtgttt ccagtttggg tagtggtggg catagttact gctgtggtcc taggtctcac    720

tctgctcatc agcatgattc tggctgtcct ctatagaagg aaaaactcta aacgggatta    780

cactggggcc cagtcatata tgcacagtta gaccactccg gcggacatca cagtgacaag    840

attaacaagt cagagtctgt ggtgtatgcg gatatccgaa agaattaaga gaatacctag    900

aacatatcct cagcaagaaa caaaaccaaa ctggactctc gtgcagaaaa tgtagcccat    960

taccacatgt agccttggag acccaggcaa ggacaagtac acgtgtactc acagagggag   1020

agaaagatgt gtacaaagga tatgtataaa tattctattt agtcatcctg atatgaggag   1080

ccagtgttgc atgatgaaaa gatggtatga ttctacatat gtacccattg tcttgctgtt   1140

tttgtacttt cttttcaggt catttacaat tgggagattt cagaaacatt cctttcacca   1200

tcatttagaa atggtttgcc ttaatggaga caatagcaga tcctgtagta tttccagtag   1260

acatggcctt ttaatctaag ggcttaagac tgattagtct tagcatttac tgtagttgga   1320

ggatggagat gctatgatgg aagcataccc agggtggcct ttagcacagt atcagtacca   1380

tttatttgtc tgccgctttt aaaaaatacc cattggctat gccacttgaa aacaatttga   1440

gaagtttttt tgaagttttt ctcactaaaa tatggggcaa ttgttagcct tacatgttgt   1500

gtagacttac tttaagtttg cacccttgaa atgtgtcata tcaatttctg gattcataat   1560

agcaagatta gcaaaggata aatgccgaag gtcacttcat tctggacaca gttggatcaa   1620

tactgattaa gtagaaaatc caagctttgc ttgagaactt ttgtaacgtg gagagtaaaa   1680

agtatcggtt ttattctttg ctgatgtcct ttctgcttga aataacagtc accatacagc   1740

taaaggagag gagtttcttt ccttctaagt aggcagaaat ggtatcatta tgttgccgct   1800

ctccaatctc ccagagctcg ctctctagag aatcaccttc tttcgctttt tttttttttt   1860

ttgaggtaga gtctcactat gttgcccaga ctagccttga actcttgggc tcaagtgatt   1920

ctccctcctc agcctcccga gtagctggaa cgaactatag ttgcaccact gcagctggca   1980

agaatcacct tctttataaa gcgtcagtca tgcttccagc aagaggcagc atcagtcatg   2040

gctttataac agcttcatgg tgcctcaaag actgttgagg ttaatgagag cctagattag   2100

acagtttggc tgtccttccc taaaacttgt tttctcctat tcactactcc ccaccgcact   2160

taaaatctat gagtttttac tttttactgg gaatggaaag tgtggtgaag atcattcaac   2220

acttatgttg tcatttctcc cattttctga attttttttt aaatttcccc ccttttaaaa   2280

ttgttcgaaa gcccacagtt atggaaagaa ttactgtcta gatggtctgc agaacgtgtt   2340

tggggtgagt gggagtgagg ggcaatgtta ctttttctcc ctgtagtttg gagtccatta   2400

tgagctgctg ctttttcttc tcatcttgtc atcttctggg gatgtttgaa ggctgagttc   2460

caacagaatt cacaaaggga ataaaacagg attgagattt tgaggtgtgc acaaggtggt   2520

aagataaagg gcatatgagc ttcaaaacta atgctgttgc atacatgaag ccttttgttt   2580

tttgaggagc tatttttgtt attcttgtaa cgctccacct tacatgccac atctgtgtga   2640

gtcaacaggg atcaggtttg gtcaccacac atgtctgaag ctgggcagcg tctgctctgt   2700

gttctgtgtg gaatggagaa aaaaacgcct gccctgctgc cttccatgtt cataggccca   2760

gcccaagaga gtgacacaca gtgctggccc tgagacattt ccacaaagtg gtcaactctg   2820

ccttgcatcc taaaactttt tgggcatcta ttttgaaaac tataggagcc tttggaaggc   2880

ctcttatgtt tggaggggaa gggtgttgag attgtcacca tccttcaagc tgagactcct   2940

ggtgagcctt tgccaccatg aaaaccacat agctgaccag ggctgtgctt gaggtacaga   3000

ggacacacat tgtagacagg cctgtgtcat gtttccttac agtcgttttt tacagagaaa   3060

aggggcattg ttttttcact gctttctcaa cagttcctgt gaataaatga aacatttcgg   3120

agctccctga gagcaagagc cttcacttct tcttgcggtg ccgggaccat gtgttggtga   3180

agctggtgct gtgggggcca ctcactcgaa tgacacctgg aggcctgttc ctcccttacc   3240

actcccttcc ccagcccgac ttcttggcct cctgcccaac cagacacctc aaactctgtc   3300

agtgccctgg cattctggca gagaatcctc accagttctc accaaccttc cccccaggca   3360

agggcagctg ccagcatggt gctctgccag gacaggtttc cctgaaggaa gctgctcaca   3420

ctgagatgag cctctcaggg caggacctct tcccaagccc tgcacaccca cccctgcagc   3480

ccttttggct ccccttttcc ctgtgcctca gcactccttt cctggttgca gataacgaac   3540

taaggttgcc taaagggcag atctgccctc tccatgtctt cgtcctggca aacagggtcg   3600

tcttaaaatt atgcgctaat tctgtatggg agcactcaaa aggcattact tagagattga   3660

aatttcaaac tatctctagt ttttcaatgg aaatatatca gctagggaaa aaccatcaag   3720

ctcattatta ttttttgatc ttcagttgta tttttgtgaa tattttaata catctttttc   3780

aatttctgaa aaaaa                                                    3795


<210>  140
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  140

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Ala Gln Ser Tyr Met His 
        195                 200                 205             


Ser 
    


<210>  141
<211>  5061
<212>  DNA
<213>  Homosapiens

<400>  141
gacagacatg gcgcttcagc tgtcttcaga ataatgtcac ccggcctcct ctcctgtctt     60

ctgcagtctt aaaagaccta gtccctaact gaggtctggc ttttcctcag ccctggatga    120

agtggagaag acctatttgg agactgcttc ctgtcaccat aaaatcctga acatttgtct    180

tgaacatgaa cactccaaaa gaagaattcc aggactggcc catagtcaga atagcagctc    240

atttaccaga cctcattgtc tatggacatt tctccccaga gcgacccttt atggattatt    300

ttgacggagt cctgatgttt gttgatattt caggttttac tgcaatgact gagaagttca    360

gcagtgccat gtacatggac agaggggctg agcagttggt ggagatcctc aactaccaca    420

taagtgcaat agtggagaaa gtgttgattt ttggaggaga catcctgaaa tttgcaggtg    480

atgcactgct agccctgtgg agggtggagc gaaagcagct gaaaaacatt atcacagtgg    540

taattaaatg tagcctggag atccatggat tgtttgagac ccaggagtgg gaagaaggcc    600

tagacatccg agtcaagata ggactggctg ctggccacat cagcatgttg gtctttggag    660

atgaaacaca cagccacttt ctggtgattg gtcaggcagt ggacgatgtg cgccttgccc    720

agaacatggc tcagatgaat gatgttattc tgtcaccaaa ctgctggcag ctctgtgacc    780

ggagcatgat tgaaattgag agtgttccag atcagagagc agttaaggtt aacttcttaa    840

aaccaccccc caattttaat tttgatgaat ttttcacaaa gtgtacgacc ttcatgcatt    900

attatccttc tggtgagcac aaaaacctcc tgaggcttgc atgcacgctg aagcctgatc    960

ctgaactgga gatgtcccta caaaagtatg tgatggaaag cattttgaag cagattgata   1020

acaaacagct tcagggctat ttatctgagc ttcgcccagt gacgattgtg tttgtgaacc   1080

tgatgtttga agaccaagac aaagcagaag agataggccc agccatccag gatgcctata   1140

tgcacatcac ttctgtcctg aagatcttcc aaggccaaat caataaagtc ttcatgtttg   1200

acaagggctg ctctttcctc tgtgtctttg gcttccctgg ggaaaaggta cctgacgagc   1260

tcactcatgc tctggaatgt gctatggata tatttgactt ctgctctcaa gtccacaaaa   1320

tccaaactgt atccatcggt gttgccagtg ggattgtctt ctgtgggatc gttggacaca   1380

ctgtgagaca cgagtacaca gtcattggtc aaaaagtcaa cttagctgcc aggatgatga   1440

tgtactaccc aggaattgtg acctgcgact ctgtcaccta caatgggagc aacctaccag   1500

cgtacttttt taaagagctt ccaaagaaag ttatgaaagg tgttgcagat tctggaccat   1560

tgtatcagta ttggggccgt actgagaaag tcatgtttgg tatggcgtgc ctcatctgca   1620

acagaaagga ggattaccct ttgctgggac gtaataaaga gatcaactac ttcatgtata   1680

ctatgaagaa atttttgata tctaacagca gccaagtctt aatgtatgag ggattaccag   1740

gatatggaaa aagccagata cttatgaaaa ttgagtacct ggcccaaggt aagaatcaca   1800

ggattattgc catttcattg aataagatca gcttccatca aactttctat accatccaga   1860

tgttcatggc caatgtccta ggcctagaca cttgtaaaca ttataaagaa cgacagacca   1920

accttcgaaa taaagtcatg acactgttgg atgaaaagtt ctactgtctt cttaatgaca   1980

ttttccatgt tcagttccct atttctcggg agatttccag gatgagcacc ttgaaaaagc   2040

aaaaacaatt ggaaatattg tttatgaaga tcttgaagct gatagtgaaa gaggaaagga   2100

ttatttttat cattgatgag gcccagtttg tggattcgac ctcctggaga tttatggaga   2160

agcttatccg gactcttcct atcttcatca ttatgtccct gtgtcccttc gttaacattc   2220

cctgtgcagc tgccagggcc gtaataaaga acaggaacac cacctacatt gtcgttggtg   2280

cagtacagcc taacgacatc tccaacaaga tctgtcttga cctcaatgtg agctgcatct   2340

ccaaagaact ggactcgtac ctgggggagg gaagctgtgg gattccattt tactgtgaag   2400

aattgcttaa aaacctggaa catcatgagg tactcgtttt ccaacaaacg gagtctgagg   2460

aaaagacaaa taggacctgg aataacctgt tcaagtattc cattaagcta acagagaagt   2520

taaacatggt tactctccat agtgataagg aaagtgaaga agtctgtcac ctcacaagtg   2580

gtgtcagact gaaaaacctg tcacctccaa cgtcattaaa agaaatctct ctgatccagc   2640

tggatagcat gagactttcc caccaaatgc tggtgagatg tgctgccatc attggcctga   2700

ccttcaccac tgagttgttg tttgagattc tcccctgttg gaatatgaag atgatgatca   2760

agaccctggc aaccctagtg gaatctaaca ttttttattg tttccggaat ggcaaggagc   2820

ttcaaaaggc cctgaaacag aatgatccct catttgaggt gcactatcgt tccttgtctc   2880

tgaagcccag tgaagggatg gatcacggtg aagaggaaca gcttcgtgaa ctggagaatg   2940

aggtgatcga gtgccacagg attcgattct gtaaccctat gatgcagaaa acagcctacg   3000

agctgtggct caaggaccag agaaaagcca tgcacttgaa atgtgcccgc tttttagaag   3060

aagatgccca cagatgtgac cactgccgag gcagggactt cattccctat catcacttca   3120

cagtgaatat tcggctcaac gctttagaca tggatgccat taaaaagatg gctatgtctc   3180

atggatttaa aactgaagaa aagcttatct tgtccaactc agagattcct gagacatctg   3240

cattttttcc tgaaaatcgc agtcctgaag aaataagaga aaagatcttg aatttctttg   3300

accacgtttt aacaaaaatg aagacatctg acgaagacat tatccctctg gaatcttgcc   3360

agtgtgaaga aatcctagag attgtcatct tgcctctggc ccaccatttt ctggctttgg   3420

gagaaaatga caaagcctta tattacttct tagaaattgc atctgcttat ctcatctttt   3480

gtgataacta catggcatac atgtatttga atgaaggaca gaagttgcta aaaactctca   3540

agaaggacaa atcttggagc cagacatttg agtctgccac cttttacagc ctcaaaggtg   3600

aggtctgttt caatatgggc cagatagtgc ttgccaagaa aatgctgagg aaggcactga   3660

agctcctcaa ccgaatcttt ccttacaact taatctcctt gtttctccat atccatgtcg   3720

agaaaaacag acactttcat tatgtgaatc ggcaggccca agagagccca cctccaggga   3780

agaagaggct ggcacaactt taccggcaaa ctgtctgcct ttccttgctg tggcgcatct   3840

atagctacag ttatcttttt cactgcaagt attatgccca cctggcagtt atgatgcaaa   3900

tgaatactgc actggaaact caaaattgtt tccagatcat taaggcttac ctagactatt   3960

cgctatacca ccacctggct ggctacaaag gtgtgtggtt caaatatgaa gtcatggcca   4020

tggagcacat cttcaacctc cccctgaaag gcgagggcat tgaaatcgtg gcatacgtgg   4080

ctgagacact ggtcttcaac aagctcataa tgggacacct ggatttggcc attgagttag   4140

gctcccgagc ccttcagatg tgggcactgc tccagaatcc caaccgacat tatcagtccc   4200

tctgcagact tagcagatgt ctccttctga acagcagata cccgcaattg atccaggtgc   4260

tggggcggct gtgggagctt tctgtaacac aggaacacat cttcagcaag gcatttttct   4320

attttgtctg cttggacatc ctgctttatt ctggttttgt ttatagaaca tttgaagaat   4380

gtttggaatt catacaccaa tacgaaaaca acagaatcct caagttccac agtggactcc   4440

tcctgggact ttattcctct gtagctatct ggtatgccag acttcaggaa tgggacaact   4500

tttacaaatt ttccaataga gctaaaaatc ttttgccaag aagaaccatg acacttactt   4560

actatgacgg aatatctagg tacatggagg ggcaagttct tcaccttcaa aaacaaatca   4620

aagaacagtc agagaatgcc caagccagtg gggaggagct actcaagaac ttggagaatc   4680

tggtggctca aaataccact ggccctgtct tttgcccaag gctctaccac ctgatggctt   4740

acgtctgtat attaatggga gatgggcaga aatgtggcct cttcctgaac acagccttgc   4800

ggctctctga aacacagggg aatatactgg agaaatgctg gctgaacatg aacaaagaat   4860

catggtactc aacctctgag ttaaaagaag accaatggct tcagacgatc ttgagtctcc   4920

catcatggga aaaaattgta gcaggcaggg taaacattca ggatcttcaa aaaaacaaat   4980

tcctgatgag agctaatacc gtggacaatc atttctaaca tgtcaaagaa aaaagatttt   5040

aataagcact aaaaaaaaaa a                                             5061


<210>  142
<211>  1610
<212>  PRT
<213>  Homosapiens

<400>  142

Met Asn Thr Pro Lys Glu Glu Phe Gln Asp Trp Pro Ile Val Arg Ile 
1               5                   10                  15      


Ala Ala His Leu Pro Asp Leu Ile Val Tyr Gly His Phe Ser Pro Glu 
            20                  25                  30          


Arg Pro Phe Met Asp Tyr Phe Asp Gly Val Leu Met Phe Val Asp Ile 
        35                  40                  45              


Ser Gly Phe Thr Ala Met Thr Glu Lys Phe Ser Ser Ala Met Tyr Met 
    50                  55                  60                  


Asp Arg Gly Ala Glu Gln Leu Val Glu Ile Leu Asn Tyr His Ile Ser 
65                  70                  75                  80  


Ala Ile Val Glu Lys Val Leu Ile Phe Gly Gly Asp Ile Leu Lys Phe 
                85                  90                  95      


Ala Gly Asp Ala Leu Leu Ala Leu Trp Arg Val Glu Arg Lys Gln Leu 
            100                 105                 110         


Lys Asn Ile Ile Thr Val Val Ile Lys Cys Ser Leu Glu Ile His Gly 
        115                 120                 125             


Leu Phe Glu Thr Gln Glu Trp Glu Glu Gly Leu Asp Ile Arg Val Lys 
    130                 135                 140                 


Ile Gly Leu Ala Ala Gly His Ile Ser Met Leu Val Phe Gly Asp Glu 
145                 150                 155                 160 


Thr His Ser His Phe Leu Val Ile Gly Gln Ala Val Asp Asp Val Arg 
                165                 170                 175     


Leu Ala Gln Asn Met Ala Gln Met Asn Asp Val Ile Leu Ser Pro Asn 
            180                 185                 190         


Cys Trp Gln Leu Cys Asp Arg Ser Met Ile Glu Ile Glu Ser Val Pro 
        195                 200                 205             


Asp Gln Arg Ala Val Lys Val Asn Phe Leu Lys Pro Pro Pro Asn Phe 
    210                 215                 220                 


Asn Phe Asp Glu Phe Phe Thr Lys Cys Thr Thr Phe Met His Tyr Tyr 
225                 230                 235                 240 


Pro Ser Gly Glu His Lys Asn Leu Leu Arg Leu Ala Cys Thr Leu Lys 
                245                 250                 255     


Pro Asp Pro Glu Leu Glu Met Ser Leu Gln Lys Tyr Val Met Glu Ser 
            260                 265                 270         


Ile Leu Lys Gln Ile Asp Asn Lys Gln Leu Gln Gly Tyr Leu Ser Glu 
        275                 280                 285             


Leu Arg Pro Val Thr Ile Val Phe Val Asn Leu Met Phe Glu Asp Gln 
    290                 295                 300                 


Asp Lys Ala Glu Glu Ile Gly Pro Ala Ile Gln Asp Ala Tyr Met His 
305                 310                 315                 320 


Ile Thr Ser Val Leu Lys Ile Phe Gln Gly Gln Ile Asn Lys Val Phe 
                325                 330                 335     


Met Phe Asp Lys Gly Cys Ser Phe Leu Cys Val Phe Gly Phe Pro Gly 
            340                 345                 350         


Glu Lys Val Pro Asp Glu Leu Thr His Ala Leu Glu Cys Ala Met Asp 
        355                 360                 365             


Ile Phe Asp Phe Cys Ser Gln Val His Lys Ile Gln Thr Val Ser Ile 
    370                 375                 380                 


Gly Val Ala Ser Gly Ile Val Phe Cys Gly Ile Val Gly His Thr Val 
385                 390                 395                 400 


Arg His Glu Tyr Thr Val Ile Gly Gln Lys Val Asn Leu Ala Ala Arg 
                405                 410                 415     


Met Met Met Tyr Tyr Pro Gly Ile Val Thr Cys Asp Ser Val Thr Tyr 
            420                 425                 430         


Asn Gly Ser Asn Leu Pro Ala Tyr Phe Phe Lys Glu Leu Pro Lys Lys 
        435                 440                 445             


Val Met Lys Gly Val Ala Asp Ser Gly Pro Leu Tyr Gln Tyr Trp Gly 
    450                 455                 460                 


Arg Thr Glu Lys Val Met Phe Gly Met Ala Cys Leu Ile Cys Asn Arg 
465                 470                 475                 480 


Lys Glu Asp Tyr Pro Leu Leu Gly Arg Asn Lys Glu Ile Asn Tyr Phe 
                485                 490                 495     


Met Tyr Thr Met Lys Lys Phe Leu Ile Ser Asn Ser Ser Gln Val Leu 
            500                 505                 510         


Met Tyr Glu Gly Leu Pro Gly Tyr Gly Lys Ser Gln Ile Leu Met Lys 
        515                 520                 525             


Ile Glu Tyr Leu Ala Gln Gly Lys Asn His Arg Ile Ile Ala Ile Ser 
    530                 535                 540                 


Leu Asn Lys Ile Ser Phe His Gln Thr Phe Tyr Thr Ile Gln Met Phe 
545                 550                 555                 560 


Met Ala Asn Val Leu Gly Leu Asp Thr Cys Lys His Tyr Lys Glu Arg 
                565                 570                 575     


Gln Thr Asn Leu Arg Asn Lys Val Met Thr Leu Leu Asp Glu Lys Phe 
            580                 585                 590         


Tyr Cys Leu Leu Asn Asp Ile Phe His Val Gln Phe Pro Ile Ser Arg 
        595                 600                 605             


Glu Ile Ser Arg Met Ser Thr Leu Lys Lys Gln Lys Gln Leu Glu Ile 
    610                 615                 620                 


Leu Phe Met Lys Ile Leu Lys Leu Ile Val Lys Glu Glu Arg Ile Ile 
625                 630                 635                 640 


Phe Ile Ile Asp Glu Ala Gln Phe Val Asp Ser Thr Ser Trp Arg Phe 
                645                 650                 655     


Met Glu Lys Leu Ile Arg Thr Leu Pro Ile Phe Ile Ile Met Ser Leu 
            660                 665                 670         


Cys Pro Phe Val Asn Ile Pro Cys Ala Ala Ala Arg Ala Val Ile Lys 
        675                 680                 685             


Asn Arg Asn Thr Thr Tyr Ile Val Val Gly Ala Val Gln Pro Asn Asp 
    690                 695                 700                 


Ile Ser Asn Lys Ile Cys Leu Asp Leu Asn Val Ser Cys Ile Ser Lys 
705                 710                 715                 720 


Glu Leu Asp Ser Tyr Leu Gly Glu Gly Ser Cys Gly Ile Pro Phe Tyr 
                725                 730                 735     


Cys Glu Glu Leu Leu Lys Asn Leu Glu His His Glu Val Leu Val Phe 
            740                 745                 750         


Gln Gln Thr Glu Ser Glu Glu Lys Thr Asn Arg Thr Trp Asn Asn Leu 
        755                 760                 765             


Phe Lys Tyr Ser Ile Lys Leu Thr Glu Lys Leu Asn Met Val Thr Leu 
    770                 775                 780                 


His Ser Asp Lys Glu Ser Glu Glu Val Cys His Leu Thr Ser Gly Val 
785                 790                 795                 800 


Arg Leu Lys Asn Leu Ser Pro Pro Thr Ser Leu Lys Glu Ile Ser Leu 
                805                 810                 815     


Ile Gln Leu Asp Ser Met Arg Leu Ser His Gln Met Leu Val Arg Cys 
            820                 825                 830         


Ala Ala Ile Ile Gly Leu Thr Phe Thr Thr Glu Leu Leu Phe Glu Ile 
        835                 840                 845             


Leu Pro Cys Trp Asn Met Lys Met Met Ile Lys Thr Leu Ala Thr Leu 
    850                 855                 860                 


Val Glu Ser Asn Ile Phe Tyr Cys Phe Arg Asn Gly Lys Glu Leu Gln 
865                 870                 875                 880 


Lys Ala Leu Lys Gln Asn Asp Pro Ser Phe Glu Val His Tyr Arg Ser 
                885                 890                 895     


Leu Ser Leu Lys Pro Ser Glu Gly Met Asp His Gly Glu Glu Glu Gln 
            900                 905                 910         


Leu Arg Glu Leu Glu Asn Glu Val Ile Glu Cys His Arg Ile Arg Phe 
        915                 920                 925             


Cys Asn Pro Met Met Gln Lys Thr Ala Tyr Glu Leu Trp Leu Lys Asp 
    930                 935                 940                 


Gln Arg Lys Ala Met His Leu Lys Cys Ala Arg Phe Leu Glu Glu Asp 
945                 950                 955                 960 


Ala His Arg Cys Asp His Cys Arg Gly Arg Asp Phe Ile Pro Tyr His 
                965                 970                 975     


His Phe Thr Val Asn Ile Arg Leu Asn Ala Leu Asp Met Asp Ala Ile 
            980                 985                 990         


Lys Lys Met Ala Met Ser His Gly  Phe Lys Thr Glu Glu  Lys Leu Ile 
        995                 1000                 1005             


Leu Ser  Asn Ser Glu Ile Pro  Glu Thr Ser Ala Phe  Phe Pro Glu 
    1010                 1015                 1020             


Asn Arg  Ser Pro Glu Glu Ile  Arg Glu Lys Ile Leu  Asn Phe Phe 
    1025                 1030                 1035             


Asp His  Val Leu Thr Lys Met  Lys Thr Ser Asp Glu  Asp Ile Ile 
    1040                 1045                 1050             


Pro Leu  Glu Ser Cys Gln Cys  Glu Glu Ile Leu Glu  Ile Val Ile 
    1055                 1060                 1065             


Leu Pro  Leu Ala His His Phe  Leu Ala Leu Gly Glu  Asn Asp Lys 
    1070                 1075                 1080             


Ala Leu  Tyr Tyr Phe Leu Glu  Ile Ala Ser Ala Tyr  Leu Ile Phe 
    1085                 1090                 1095             


Cys Asp  Asn Tyr Met Ala Tyr  Met Tyr Leu Asn Glu  Gly Gln Lys 
    1100                 1105                 1110             


Leu Leu  Lys Thr Leu Lys Lys  Asp Lys Ser Trp Ser  Gln Thr Phe 
    1115                 1120                 1125             


Glu Ser  Ala Thr Phe Tyr Ser  Leu Lys Gly Glu Val  Cys Phe Asn 
    1130                 1135                 1140             


Met Gly  Gln Ile Val Leu Ala  Lys Lys Met Leu Arg  Lys Ala Leu 
    1145                 1150                 1155             


Lys Leu  Leu Asn Arg Ile Phe  Pro Tyr Asn Leu Ile  Ser Leu Phe 
    1160                 1165                 1170             


Leu His  Ile His Val Glu Lys  Asn Arg His Phe His  Tyr Val Asn 
    1175                 1180                 1185             


Arg Gln  Ala Gln Glu Ser Pro  Pro Pro Gly Lys Lys  Arg Leu Ala 
    1190                 1195                 1200             


Gln Leu  Tyr Arg Gln Thr Val  Cys Leu Ser Leu Leu  Trp Arg Ile 
    1205                 1210                 1215             


Tyr Ser  Tyr Ser Tyr Leu Phe  His Cys Lys Tyr Tyr  Ala His Leu 
    1220                 1225                 1230             


Ala Val  Met Met Gln Met Asn  Thr Ala Leu Glu Thr  Gln Asn Cys 
    1235                 1240                 1245             


Phe Gln  Ile Ile Lys Ala Tyr  Leu Asp Tyr Ser Leu  Tyr His His 
    1250                 1255                 1260             


Leu Ala  Gly Tyr Lys Gly Val  Trp Phe Lys Tyr Glu  Val Met Ala 
    1265                 1270                 1275             


Met Glu  His Ile Phe Asn Leu  Pro Leu Lys Gly Glu  Gly Ile Glu 
    1280                 1285                 1290             


Ile Val  Ala Tyr Val Ala Glu  Thr Leu Val Phe Asn  Lys Leu Ile 
    1295                 1300                 1305             


Met Gly  His Leu Asp Leu Ala  Ile Glu Leu Gly Ser  Arg Ala Leu 
    1310                 1315                 1320             


Gln Met  Trp Ala Leu Leu Gln  Asn Pro Asn Arg His  Tyr Gln Ser 
    1325                 1330                 1335             


Leu Cys  Arg Leu Ser Arg Cys  Leu Leu Leu Asn Ser  Arg Tyr Pro 
    1340                 1345                 1350             


Gln Leu  Ile Gln Val Leu Gly  Arg Leu Trp Glu Leu  Ser Val Thr 
    1355                 1360                 1365             


Gln Glu  His Ile Phe Ser Lys  Ala Phe Phe Tyr Phe  Val Cys Leu 
    1370                 1375                 1380             


Asp Ile  Leu Leu Tyr Ser Gly  Phe Val Tyr Arg Thr  Phe Glu Glu 
    1385                 1390                 1395             


Cys Leu  Glu Phe Ile His Gln  Tyr Glu Asn Asn Arg  Ile Leu Lys 
    1400                 1405                 1410             


Phe His  Ser Gly Leu Leu Leu  Gly Leu Tyr Ser Ser  Val Ala Ile 
    1415                 1420                 1425             


Trp Tyr  Ala Arg Leu Gln Glu  Trp Asp Asn Phe Tyr  Lys Phe Ser 
    1430                 1435                 1440             


Asn Arg  Ala Lys Asn Leu Leu  Pro Arg Arg Thr Met  Thr Leu Thr 
    1445                 1450                 1455             


Tyr Tyr  Asp Gly Ile Ser Arg  Tyr Met Glu Gly Gln  Val Leu His 
    1460                 1465                 1470             


Leu Gln  Lys Gln Ile Lys Glu  Gln Ser Glu Asn Ala  Gln Ala Ser 
    1475                 1480                 1485             


Gly Glu  Glu Leu Leu Lys Asn  Leu Glu Asn Leu Val  Ala Gln Asn 
    1490                 1495                 1500             


Thr Thr  Gly Pro Val Phe Cys  Pro Arg Leu Tyr His  Leu Met Ala 
    1505                 1510                 1515             


Tyr Val  Cys Ile Leu Met Gly  Asp Gly Gln Lys Cys  Gly Leu Phe 
    1520                 1525                 1530             


Leu Asn  Thr Ala Leu Arg Leu  Ser Glu Thr Gln Gly  Asn Ile Leu 
    1535                 1540                 1545             


Glu Lys  Cys Trp Leu Asn Met  Asn Lys Glu Ser Trp  Tyr Ser Thr 
    1550                 1555                 1560             


Ser Glu  Leu Lys Glu Asp Gln  Trp Leu Gln Thr Ile  Leu Ser Leu 
    1565                 1570                 1575             


Pro Ser  Trp Glu Lys Ile Val  Ala Gly Arg Val Asn  Ile Gln Asp 
    1580                 1585                 1590             


Leu Gln  Lys Asn Lys Phe Leu  Met Arg Ala Asn Thr  Val Asp Asn 
    1595                 1600                 1605             


His Phe  
    1610 


<210>  143
<211>  811
<212>  DNA
<213>  Homosapiens

<400>  143
gggacagcgg gcagggaaag ccgcgggaag ggtactccag gcgagaggcg gacgcgagtc     60

gtcgtggcag gaaaagtgac tagctcccct tcgttgtcag ccagggacga gaacacagcc    120

acgctcccac ccggctgcca acgatccctc ggcggcgatg tcggccgccg gtgcccgagg    180

cctgcgggcc acctaccacc ggctcctcga taaagtggag ctgatgctgc ccgagaaatt    240

gaggccgttg tacaaccatc cagcaggtcc cagaacagtt ttcttctggg ctccaattat    300

gaaatggggg ttggtgtgtg ctggattggc tgatatggcc agacctgcag aaaaacttag    360

cacagctcaa tctgctgttt tgatggctac agggtttatt tggtcaagat actcacttgt    420

aattattcca aaaaattgga gtctgtttgc tgttaatttc tttgtggggg cagcaggagc    480

ctctcagctt tttcgtattt ggagatataa ccaagaacta aaagctaaag cacacaaata    540

aaagagttcc tgatcacctg aacaatctag atgtggacaa aaccattggg acctagttta    600

ttatttggtt attgataaag caaagctaac tgtgtgttta gaaggcactg taactggtag    660

ctagttcttg attcaataga aaaatgcagc aaacttttaa taacagtctc tctacatgac    720

ttaaggaact tatctatgga tattagtaac atttttctac catttgtccg taataaacca    780

tacttgctcg taaaaaaaaa aaaaaaaaaa a                                   811


<210>  144
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  144

Met Ser Ala Ala Gly Ala Arg Gly Leu Arg Ala Thr Tyr His Arg Leu 
1               5                   10                  15      


Leu Asp Lys Val Glu Leu Met Leu Pro Glu Lys Leu Arg Pro Leu Tyr 
            20                  25                  30          


Asn His Pro Ala Gly Pro Arg Thr Val Phe Phe Trp Ala Pro Ile Met 
        35                  40                  45              


Lys Trp Gly Leu Val Cys Ala Gly Leu Ala Asp Met Ala Arg Pro Ala 
    50                  55                  60                  


Glu Lys Leu Ser Thr Ala Gln Ser Ala Val Leu Met Ala Thr Gly Phe 
65                  70                  75                  80  


Ile Trp Ser Arg Tyr Ser Leu Val Ile Ile Pro Lys Asn Trp Ser Leu 
                85                  90                  95      


Phe Ala Val Asn Phe Phe Val Gly Ala Ala Gly Ala Ser Gln Leu Phe 
            100                 105                 110         


Arg Ile Trp Arg Tyr Asn Gln Glu Leu Lys Ala Lys Ala His Lys 
        115                 120                 125         


<210>  145
<211>  3243
<212>  DNA
<213>  Homosapiens

<400>  145
gttgctgatc tttggatgtt ctggttagtc taagaaggag agtatgaggc gagctccggc     60

ccgggtgcgg ccgggcttca ggggcccagg cgccgctgct gccaccgcca tctaacgctg    120

cgccctggag gcccggcgcg cggatggtgc cggtgcggct cgggtgttga aacgggtgtc    180

ccctccccct cctcccctcc cccacgcggt ggtctcccct cccacccggc tcaggcagag    240

ccatgtctcg gggtggctcc tacccacacc tgttgtggga cgtgaggaaa aggtccctcg    300

ggctggagga cccgtcccgg ctgcggagtc gctacctggg aagaagagaa tttatccaaa    360

gattaaaact tgaagcaacc cttaatgtgc atgatggttg tgttaataca atctgttgga    420

atgacactgg agaatatatt ttatctggct cagatgacac caaattagta attagtaatc    480

cttacagcag aaaggttttg acaacaattc gttcagggca ccgagcaaac atatttagtg    540

caaagttctt accttgtaca aatgataaac agattgtatc ctgctctgga gatggagtaa    600

tattttatac caacgttgag caagatgcag aaaccaacag acaatgccaa tttacgtgtc    660

attatggaac tacttatgag attatgactg tacccaatga cccttacact tttctctctt    720

gtggtgaaga tggaactgtt aggtggtttg atacacgcat caaaactagc tgcacaaaag    780

aagattgtaa agatgatatt ttaattaact gtcgacgtgc tgccacgtct gttgctattt    840

gcccaccaat accatattac cttgctgttg gttgttctga cagctcagta cgaatatatg    900

atcggcgaat gctgggcaca agagctacag ggaattatgc aggtcgaggg actactggaa    960

tggttgcccg ttttattcct tcccatctta ataataagtc ctgcagagtg acatctctgt   1020

gttacagtga agatggtcaa gagattctcg ttagttactc ttcagattac atatatcttt   1080

ttgacccgaa agatgataca gcacgagaac ttaaaactcc ttctgcggaa gagagaagag   1140

aagagttgcg acaaccacca gttaagcgtt tgagacttcg tggtgattgg tcagatactg   1200

gacccagagc aaggccggag agtgaacgag aacgagatgg agagcagagt cccaatgtgt   1260

cattgatgca gagaatgtct gatatgttat caagatggtt tgaagaagca agtgaggttg   1320

cacaaagcaa tagaggacga ggaagatctc gacccagagg tggaacaagt caatcagata   1380

tttcaactct tcctacggtc ccatcaagtc ctgatttgga agtgagtgaa actgcaatgg   1440

aagtagatac tccagctgaa caatttcttc agccttctac atcctctaca atgtcagctc   1500

aggctcattc gacatcatct cccacagaaa gccctcattc tactcctttg ctatcttctc   1560

cagacagtga acaaaggcag tctgttgagg catctggaca ccacacacat catcagtctg   1620

ataacaataa tgaaaagctg agccccaaac cagggacagg tgaaccagtt ttaagtttgc   1680

actacagcac agaaggaaca actacaagca caataaaact gaactttaca gatgaatgga   1740

gcagtatagc atcaagttct agaggaattg ggagccattg caaatctgag ggtcaggagg   1800

aatctttcgt cccacagagc tcagtgcaac caccagaagg agacagtgaa acaaaagctc   1860

ctgaagaatc atcagaggat gtgacaaaat atcaggaagg agtatctgca gaaaacccag   1920

ttgagaacca tatcaatata acacaatcag ataagttcac agccaagcca ttggattcca   1980

actcaggaga aagaaatgac ctcaatcttg atcgctcttg tggggttcca gaagaatctg   2040

cttcatctga aaaagccaag gaaccagaaa cttcagatca gactagcact gagagtgcta   2100

ccaatgaaaa taacaccaat cctgagcctc agttccaaac agaagccact gggccttcag   2160

ctcatgaaga aacatccacc agggactctg ctcttcagga cacagatgac agtgatgatg   2220

acccagtcct gatcccaggt gcaaggtatc gagcaggacc tggtgataga cgctctgctg   2280

ttgcccgtat tcaggagttc ttcagacgga gaaaagaaag gaaagaaatg gaagaattgg   2340

atactttgaa cattagaagg ccgctagtaa aaatggttta taaaggccat cgcaactcca   2400

ggacaatgat aaaagaagcc aatttctggg gtgctaactt tgtaatgagt ggttctgact   2460

gtggccacat tttcatctgg gatcggcaca ctgctgagca tttgatgctt ctggaagctg   2520

ataatcatgt ggtaaactgc ctgcagccac atccgtttga cccaatttta gcctcatctg   2580

gcatagatta tgacataaag atctggtcac cattagaaga gtcaaggatt tttaaccgaa   2640

aacttgctga tgaagttata actcgaaacg aactcatgct ggaagaaact agaaacacca   2700

ttacagttcc agcctctttc atgttgagga tgttggcttc acttaatcat atccgagctg   2760

accggttgga gggtgacaga tcagaaggct ctggtcaaga gaatgaaaat gaggatgagg   2820

aataataaac tctttttggc aagcacttaa atgttctgaa atttgtataa gacatttatt   2880

atattttttt ctttacagag ctttagtgca attttaaggt tatggttttt ggagtttttc   2940

cctttttttg ggataaccta acattggttt ggaatgattg tgtgcatgaa tttgggagat   3000

tgtataaaac aaaactagca gaatgttttt aaaacttttt gccgtgtatg aggagtgcta   3060

gaaaatgcaa agtgcaatat tttccctaac cttcaaatgt gggagcttgg atcaatgttg   3120

aagaataatt ttcatcatag tgaaaatgtt ggttcaaata aatttctaca cttgccattt   3180

gcatgtttgt tgctttctaa ttaaagaaac tggttgtttt aagataccct gaaaaaaaaa   3240

aaa                                                                 3243


<210>  146
<211>  860
<212>  PRT
<213>  Homosapiens

<400>  146

Met Ser Arg Gly Gly Ser Tyr Pro His Leu Leu Trp Asp Val Arg Lys 
1               5                   10                  15      


Arg Ser Leu Gly Leu Glu Asp Pro Ser Arg Leu Arg Ser Arg Tyr Leu 
            20                  25                  30          


Gly Arg Arg Glu Phe Ile Gln Arg Leu Lys Leu Glu Ala Thr Leu Asn 
        35                  40                  45              


Val His Asp Gly Cys Val Asn Thr Ile Cys Trp Asn Asp Thr Gly Glu 
    50                  55                  60                  


Tyr Ile Leu Ser Gly Ser Asp Asp Thr Lys Leu Val Ile Ser Asn Pro 
65                  70                  75                  80  


Tyr Ser Arg Lys Val Leu Thr Thr Ile Arg Ser Gly His Arg Ala Asn 
                85                  90                  95      


Ile Phe Ser Ala Lys Phe Leu Pro Cys Thr Asn Asp Lys Gln Ile Val 
            100                 105                 110         


Ser Cys Ser Gly Asp Gly Val Ile Phe Tyr Thr Asn Val Glu Gln Asp 
        115                 120                 125             


Ala Glu Thr Asn Arg Gln Cys Gln Phe Thr Cys His Tyr Gly Thr Thr 
    130                 135                 140                 


Tyr Glu Ile Met Thr Val Pro Asn Asp Pro Tyr Thr Phe Leu Ser Cys 
145                 150                 155                 160 


Gly Glu Asp Gly Thr Val Arg Trp Phe Asp Thr Arg Ile Lys Thr Ser 
                165                 170                 175     


Cys Thr Lys Glu Asp Cys Lys Asp Asp Ile Leu Ile Asn Cys Arg Arg 
            180                 185                 190         


Ala Ala Thr Ser Val Ala Ile Cys Pro Pro Ile Pro Tyr Tyr Leu Ala 
        195                 200                 205             


Val Gly Cys Ser Asp Ser Ser Val Arg Ile Tyr Asp Arg Arg Met Leu 
    210                 215                 220                 


Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr Gly Met 
225                 230                 235                 240 


Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys Arg Val 
                245                 250                 255     


Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val Ser Tyr 
            260                 265                 270         


Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr Ala Arg 
        275                 280                 285             


Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu Arg Gln 
    290                 295                 300                 


Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp Thr Gly 
305                 310                 315                 320 


Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu Gln Ser 
                325                 330                 335     


Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser Arg Trp 
            340                 345                 350         


Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg Gly Arg 
        355                 360                 365             


Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr Leu Pro 
    370                 375                 380                 


Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala Met Glu 
385                 390                 395                 400 


Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr 
                405                 410                 415     


Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser Pro His 
            420                 425                 430         


Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln Ser Val 
        435                 440                 445             


Glu Ala Ser Gly His His Thr His His Gln Ser Asp Asn Asn Asn Glu 
    450                 455                 460                 


Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val Leu Ser Leu His 
465                 470                 475                 480 


Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu Asn Phe Thr 
                485                 490                 495     


Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile Gly Ser His 
            500                 505                 510         


Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro Gln Ser Ser Val 
        515                 520                 525             


Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu Glu Ser Ser 
    530                 535                 540                 


Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu Asn Pro Val 
545                 550                 555                 560 


Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr Ala Lys Pro 
                565                 570                 575     


Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu Asp Arg Ser 
            580                 585                 590         


Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala Lys Glu Pro 
        595                 600                 605             


Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn Glu Asn Asn 
    610                 615                 620                 


Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly Pro Ser Ala 
625                 630                 635                 640 


His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp Thr Asp Asp 
                645                 650                 655     


Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr Arg Ala Gly 
            660                 665                 670         


Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln Glu Phe Phe Arg 
        675                 680                 685             


Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp Thr Leu Asn Ile 
    690                 695                 700                 


Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His Arg Asn Ser Arg 
705                 710                 715                 720 


Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn Phe Val Met Ser 
                725                 730                 735     


Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg His Thr Ala Glu 
            740                 745                 750         


His Leu Met Leu Leu Glu Ala Asp Asn His Val Val Asn Cys Leu Gln 
        755                 760                 765             


Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly Ile Asp Tyr Asp 
    770                 775                 780                 


Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile Phe Asn Arg Lys 
785                 790                 795                 800 


Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met Leu Glu Glu Thr 
                805                 810                 815     


Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu Arg Met Leu Ala 
            820                 825                 830         


Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly Asp Arg Ser Glu 
        835                 840                 845             


Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu 
    850                 855                 860 


<210>  147
<211>  3303
<212>  DNA
<213>  Homosapiens

<400>  147
gttgctgatc tttggatgtt ctggttagtc taagaaggag agtatgaggc gagctccggc     60

ccgggtgcgg ccgggcttca ggggcccagg cgccgctgct gccaccgcca tctaacgctg    120

cgccctggag gcccggcgcg cggatggtgc cggtgcggct cgggtgttga aacgggtgtc    180

ccctccccct cctcccctcc cccacgcggt ggtctcccct cccacccggc tcaggcagag    240

ccatgtctcg gggtggctcc tacccacacc tgttgtggga cgtgaggaaa aggtccctcg    300

ggctggagga cccgtcccgg ctgcggagtc gctacctggg aagaagagaa tttatccaaa    360

gattaaaact tgaagcaacc cttaatgtgc atgatggttg tgttaataca atctgttgga    420

atgacactgg agaatatatt ttatctggct cagatgacac caaattagta attagtaatc    480

cttacagcag aaaggttttg acaacaattc gttcagggca ccgagcaaac atatttagtg    540

caaagttctt accttgtaca aatgataaac agattgtatc ctgctctgga gatggagtaa    600

tattttatac caacgttgag caagatgcag aaaccaacag acaatgccaa tttacgtgtc    660

attatggaac tacttatgag attatgactg tacccaatga cccttacact tttctctctt    720

gtggtgaaga tggaactgtt aggtggtttg atacacgcat caaaactagc tgcacaaaag    780

aagattgtaa agatgatatt ttaattaact gtcgacgtgc tgccacgtct gttgctattt    840

gcccaccaat accatattac cttgctgttg gttgttctga cagctcagta cgaatatatg    900

atcggcgaat gctgggcaca agagctacag ggaattatgc aggtcgaggg actactggaa    960

tggttgcccg ttttattcct tcccatctta ataataagtc ctgcagagtg acatctctgt   1020

gttacagtga agatggtcaa gagattctcg ttagttactc ttcagattac atatatcttt   1080

ttgacccgaa agatgataca gcacgagaac ttaaaactcc ttctgcggaa gagagaagag   1140

aagagttgcg acaaccacca gttaagcgtt tgagacttcg tggtgattgg tcagatactg   1200

gacccagagc aaggccggag agtgaacgag aacgagatgg agagcagagt cccaatgtgt   1260

cattgatgca gagaatgtct gatatgttat caagatggtt tgaagaagca agtgaggttg   1320

cacaaagcaa tagaggacga ggaagatctc gacccagagg tggaacaagt caatcagata   1380

tttcaactct tcctacggtc ccatcaagtc ctgatttgga agtgagtgaa actgcaatgg   1440

aagtagatac tccagctgaa caatttcttc agccttctac atcctctaca atgtcagctc   1500

aggctcattc gacatcatct cccacagaaa gccctcattc tactcctttg ctatcttctc   1560

cagacagtga acaaaggcag tctgttgagg catctggaca ccacacacat catcagtctg   1620

attctccttc ttctgtggtt aacaaacagc tcggatccat gtcacttgac gagcaacagg   1680

ataacaataa tgaaaagctg agccccaaac cagggacagg tgaaccagtt ttaagtttgc   1740

actacagcac agaaggaaca actacaagca caataaaact gaactttaca gatgaatgga   1800

gcagtatagc atcaagttct agaggaattg ggagccattg caaatctgag ggtcaggagg   1860

aatctttcgt cccacagagc tcagtgcaac caccagaagg agacagtgaa acaaaagctc   1920

ctgaagaatc atcagaggat gtgacaaaat atcaggaagg agtatctgca gaaaacccag   1980

ttgagaacca tatcaatata acacaatcag ataagttcac agccaagcca ttggattcca   2040

actcaggaga aagaaatgac ctcaatcttg atcgctcttg tggggttcca gaagaatctg   2100

cttcatctga aaaagccaag gaaccagaaa cttcagatca gactagcact gagagtgcta   2160

ccaatgaaaa taacaccaat cctgagcctc agttccaaac agaagccact gggccttcag   2220

ctcatgaaga aacatccacc agggactctg ctcttcagga cacagatgac agtgatgatg   2280

acccagtcct gatcccaggt gcaaggtatc gagcaggacc tggtgataga cgctctgctg   2340

ttgcccgtat tcaggagttc ttcagacgga gaaaagaaag gaaagaaatg gaagaattgg   2400

atactttgaa cattagaagg ccgctagtaa aaatggttta taaaggccat cgcaactcca   2460

ggacaatgat aaaagaagcc aatttctggg gtgctaactt tgtaatgagt ggttctgact   2520

gtggccacat tttcatctgg gatcggcaca ctgctgagca tttgatgctt ctggaagctg   2580

ataatcatgt ggtaaactgc ctgcagccac atccgtttga cccaatttta gcctcatctg   2640

gcatagatta tgacataaag atctggtcac cattagaaga gtcaaggatt tttaaccgaa   2700

aacttgctga tgaagttata actcgaaacg aactcatgct ggaagaaact agaaacacca   2760

ttacagttcc agcctctttc atgttgagga tgttggcttc acttaatcat atccgagctg   2820

accggttgga gggtgacaga tcagaaggct ctggtcaaga gaatgaaaat gaggatgagg   2880

aataataaac tctttttggc aagcacttaa atgttctgaa atttgtataa gacatttatt   2940

atattttttt ctttacagag ctttagtgca attttaaggt tatggttttt ggagtttttc   3000

cctttttttg ggataaccta acattggttt ggaatgattg tgtgcatgaa tttgggagat   3060

tgtataaaac aaaactagca gaatgttttt aaaacttttt gccgtgtatg aggagtgcta   3120

gaaaatgcaa agtgcaatat tttccctaac cttcaaatgt gggagcttgg atcaatgttg   3180

aagaataatt ttcatcatag tgaaaatgtt ggttcaaata aatttctaca cttgccattt   3240

gcatgtttgt tgctttctaa ttaaagaaac tggttgtttt aagataccct gaaaaaaaaa   3300

aaa                                                                 3303


<210>  148
<211>  880
<212>  PRT
<213>  Homosapiens

<400>  148

Met Ser Arg Gly Gly Ser Tyr Pro His Leu Leu Trp Asp Val Arg Lys 
1               5                   10                  15      


Arg Ser Leu Gly Leu Glu Asp Pro Ser Arg Leu Arg Ser Arg Tyr Leu 
            20                  25                  30          


Gly Arg Arg Glu Phe Ile Gln Arg Leu Lys Leu Glu Ala Thr Leu Asn 
        35                  40                  45              


Val His Asp Gly Cys Val Asn Thr Ile Cys Trp Asn Asp Thr Gly Glu 
    50                  55                  60                  


Tyr Ile Leu Ser Gly Ser Asp Asp Thr Lys Leu Val Ile Ser Asn Pro 
65                  70                  75                  80  


Tyr Ser Arg Lys Val Leu Thr Thr Ile Arg Ser Gly His Arg Ala Asn 
                85                  90                  95      


Ile Phe Ser Ala Lys Phe Leu Pro Cys Thr Asn Asp Lys Gln Ile Val 
            100                 105                 110         


Ser Cys Ser Gly Asp Gly Val Ile Phe Tyr Thr Asn Val Glu Gln Asp 
        115                 120                 125             


Ala Glu Thr Asn Arg Gln Cys Gln Phe Thr Cys His Tyr Gly Thr Thr 
    130                 135                 140                 


Tyr Glu Ile Met Thr Val Pro Asn Asp Pro Tyr Thr Phe Leu Ser Cys 
145                 150                 155                 160 


Gly Glu Asp Gly Thr Val Arg Trp Phe Asp Thr Arg Ile Lys Thr Ser 
                165                 170                 175     


Cys Thr Lys Glu Asp Cys Lys Asp Asp Ile Leu Ile Asn Cys Arg Arg 
            180                 185                 190         


Ala Ala Thr Ser Val Ala Ile Cys Pro Pro Ile Pro Tyr Tyr Leu Ala 
        195                 200                 205             


Val Gly Cys Ser Asp Ser Ser Val Arg Ile Tyr Asp Arg Arg Met Leu 
    210                 215                 220                 


Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr Gly Met 
225                 230                 235                 240 


Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys Arg Val 
                245                 250                 255     


Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val Ser Tyr 
            260                 265                 270         


Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr Ala Arg 
        275                 280                 285             


Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu Arg Gln 
    290                 295                 300                 


Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp Thr Gly 
305                 310                 315                 320 


Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu Gln Ser 
                325                 330                 335     


Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser Arg Trp 
            340                 345                 350         


Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg Gly Arg 
        355                 360                 365             


Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr Leu Pro 
    370                 375                 380                 


Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala Met Glu 
385                 390                 395                 400 


Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr 
                405                 410                 415     


Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser Pro His 
            420                 425                 430         


Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln Ser Val 
        435                 440                 445             


Glu Ala Ser Gly His His Thr His His Gln Ser Asp Ser Pro Ser Ser 
    450                 455                 460                 


Val Val Asn Lys Gln Leu Gly Ser Met Ser Leu Asp Glu Gln Gln Asp 
465                 470                 475                 480 


Asn Asn Asn Glu Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val 
                485                 490                 495     


Leu Ser Leu His Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys 
            500                 505                 510         


Leu Asn Phe Thr Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly 
        515                 520                 525             


Ile Gly Ser His Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro 
    530                 535                 540                 


Gln Ser Ser Val Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro 
545                 550                 555                 560 


Glu Glu Ser Ser Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala 
                565                 570                 575     


Glu Asn Pro Val Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe 
            580                 585                 590         


Thr Ala Lys Pro Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn 
        595                 600                 605             


Leu Asp Arg Ser Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys 
    610                 615                 620                 


Ala Lys Glu Pro Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr 
625                 630                 635                 640 


Asn Glu Asn Asn Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr 
                645                 650                 655     


Gly Pro Ser Ala His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln 
            660                 665                 670         


Asp Thr Asp Asp Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg 
        675                 680                 685             


Tyr Arg Ala Gly Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln 
    690                 695                 700                 


Glu Phe Phe Arg Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp 
705                 710                 715                 720 


Thr Leu Asn Ile Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His 
                725                 730                 735     


Arg Asn Ser Arg Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn 
            740                 745                 750         


Phe Val Met Ser Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg 
        755                 760                 765             


His Thr Ala Glu His Leu Met Leu Leu Glu Ala Asp Asn His Val Val 
    770                 775                 780                 


Asn Cys Leu Gln Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly 
785                 790                 795                 800 


Ile Asp Tyr Asp Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile 
                805                 810                 815     


Phe Asn Arg Lys Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met 
            820                 825                 830         


Leu Glu Glu Thr Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu 
        835                 840                 845             


Arg Met Leu Ala Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly 
    850                 855                 860                 


Asp Arg Ser Glu Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu 
865                 870                 875                 880 


<210>  149
<211>  1382
<212>  DNA
<213>  Homosapiens

<400>  149
ggccttatct ttccagtcgt ccagcatgct ctgcccaccc cacgccgagg tgcactgacc     60

atgagcctca actcctccct cagctgcagg aaggagctga gtaatctcac tgaggaggag    120

ggtggcgaag ggggcgtcat catcacccag ttcatcgcca tcattgtcat caccattttt    180

gtctgcctgg gaaacctggt catcgtggtc accttgtaca agaagtccta cctcctcacc    240

ctcagcaaca agttcgtctt cagcctgact ctgtccaact tcctgctgtc cgtgttggtg    300

ctgccttttg tggtgacgag ctccatccgc agggaatgga tctttggtgt agtgtggtgc    360

aacttctctg ccctcctcta cctgctgatc agctctgcca gcatgctaac cctcggggtc    420

attgccatcg accgctacta tgctgtcctg taccccatgg tgtaccccat gaagatcaca    480

gggaaccggg ctgtgatggc acttgtctac atctggcttc actcgctcat cggctgcctg    540

ccacccctgt ttggttggtc atccgtggag tttgacgagt tcaaatggat gtgtgtggct    600

gcttggcacc gggagcctgg ctacacggcc ttctggcaga tctggtgtgc cctcttcccc    660

tttctggtca tgctggtgtg ctatggcttc atcttccgcg tggccagggt caaggcacgc    720

aaggtgcact gtggcacagt cgtcatcgtg gaggaggatg ctcagaggac cgggaggaag    780

aactccagca cctccacctc ctcttcaggc agcaggagga atgcctttca gggtgtggtc    840

tactcggcca accagtgcaa agccctcatc accatcctgg tggtcctcgg tgccttcatg    900

gtcacctggg gcccctacat ggttgtcatc gcctctgagg ccctctgggg gaaaagctcc    960

gtctccccga gcctggagac ttgggccaca tggctgtcct ttgccagcgc tgtctgccac   1020

cccctgatct atggactctg gaacaagaca gttcgcaaag aactactggg catgtgcttt   1080

ggggaccggt attatcggga accatttgtg caacgacaga ggacttccag gctcttcagc   1140

atttccaaca ggatcacaga cctgggcctg tccccacacc tcactgcgct catggcaggt   1200

ggacagcccc tggggcacag cagcagcacg ggggacactg gcttcagctg ctcccaggac   1260

tcaggtaacc tgcgtgcttt ataagcctct cacctgtcgc gttttccctg tgttgcgttt   1320

cccccgtgtc gcgtttcccc tgtgcaggct caagagctgg cggaggggca tttcccacgg   1380

tg                                                                  1382


<210>  150
<211>  407
<212>  PRT
<213>  Homosapiens

<400>  150

Met Ser Leu Asn Ser Ser Leu Ser Cys Arg Lys Glu Leu Ser Asn Leu 
1               5                   10                  15      


Thr Glu Glu Glu Gly Gly Glu Gly Gly Val Ile Ile Thr Gln Phe Ile 
            20                  25                  30          


Ala Ile Ile Val Ile Thr Ile Phe Val Cys Leu Gly Asn Leu Val Ile 
        35                  40                  45              


Val Val Thr Leu Tyr Lys Lys Ser Tyr Leu Leu Thr Leu Ser Asn Lys 
    50                  55                  60                  


Phe Val Phe Ser Leu Thr Leu Ser Asn Phe Leu Leu Ser Val Leu Val 
65                  70                  75                  80  


Leu Pro Phe Val Val Thr Ser Ser Ile Arg Arg Glu Trp Ile Phe Gly 
                85                  90                  95      


Val Val Trp Cys Asn Phe Ser Ala Leu Leu Tyr Leu Leu Ile Ser Ser 
            100                 105                 110         


Ala Ser Met Leu Thr Leu Gly Val Ile Ala Ile Asp Arg Tyr Tyr Ala 
        115                 120                 125             


Val Leu Tyr Pro Met Val Tyr Pro Met Lys Ile Thr Gly Asn Arg Ala 
    130                 135                 140                 


Val Met Ala Leu Val Tyr Ile Trp Leu His Ser Leu Ile Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Leu Phe Gly Trp Ser Ser Val Glu Phe Asp Glu Phe Lys Trp 
                165                 170                 175     


Met Cys Val Ala Ala Trp His Arg Glu Pro Gly Tyr Thr Ala Phe Trp 
            180                 185                 190         


Gln Ile Trp Cys Ala Leu Phe Pro Phe Leu Val Met Leu Val Cys Tyr 
        195                 200                 205             


Gly Phe Ile Phe Arg Val Ala Arg Val Lys Ala Arg Lys Val His Cys 
    210                 215                 220                 


Gly Thr Val Val Ile Val Glu Glu Asp Ala Gln Arg Thr Gly Arg Lys 
225                 230                 235                 240 


Asn Ser Ser Thr Ser Thr Ser Ser Ser Gly Ser Arg Arg Asn Ala Phe 
                245                 250                 255     


Gln Gly Val Val Tyr Ser Ala Asn Gln Cys Lys Ala Leu Ile Thr Ile 
            260                 265                 270         


Leu Val Val Leu Gly Ala Phe Met Val Thr Trp Gly Pro Tyr Met Val 
        275                 280                 285             


Val Ile Ala Ser Glu Ala Leu Trp Gly Lys Ser Ser Val Ser Pro Ser 
    290                 295                 300                 


Leu Glu Thr Trp Ala Thr Trp Leu Ser Phe Ala Ser Ala Val Cys His 
305                 310                 315                 320 


Pro Leu Ile Tyr Gly Leu Trp Asn Lys Thr Val Arg Lys Glu Leu Leu 
                325                 330                 335     


Gly Met Cys Phe Gly Asp Arg Tyr Tyr Arg Glu Pro Phe Val Gln Arg 
            340                 345                 350         


Gln Arg Thr Ser Arg Leu Phe Ser Ile Ser Asn Arg Ile Thr Asp Leu 
        355                 360                 365             


Gly Leu Ser Pro His Leu Thr Ala Leu Met Ala Gly Gly Gln Pro Leu 
    370                 375                 380                 


Gly His Ser Ser Ser Thr Gly Asp Thr Gly Phe Ser Cys Ser Gln Asp 
385                 390                 395                 400 


Ser Gly Asn Leu Arg Ala Leu 
                405         


<210>  151
<211>  2733
<212>  DNA
<213>  Homosapiens

<400>  151
gtaggtgcgt gcccgggact ctgccgatgc gggccgcgcc ccctggggcc aagagactcc     60

acgtcccgct cagggcaaag ggtgtgggga gaagcggtca cgcccctcgg ctggaatccg    120

tgaggaccag gtctttttca gtgtgctcaa tatggtcacc aagcctggaa acatagagtc    180

tcaccctgtt gcttaggcag atggcgcgat ctcggctcct gggttcaagc aattctcctg    240

cctcagcctc ctgaatagcc gggattacag tcgtccagca tgctctgccc accccacgcc    300

gaggtgcact gaccatgagc ctcaactcct ccctcagctg caggaaggag ctgagtaatc    360

tcactgagga ggagggtggc gaagggggcg tcatcatcac ccagttcatc gccatcattg    420

tcatcaccat ttttgtctgc ctgggaaacc tggtcatcgt ggtcaccttg tacaagaagt    480

cctacctcct caccctcagc aacaagttcg tcttcagcct gactctgtcc aacttcctgc    540

tgtccgtgtt ggtgctgcct tttgtggtga cgagctccat ccgcagggaa tggatctttg    600

gtgtagtgtg gtgcaacttc tctgccctcc tctacctgct gatcagctct gccagcatgc    660

taaccctcgg ggtcattgcc atcgaccgct actatgctgt cctgtacccc atggtgtacc    720

ccatgaagat cacagggaac cgggctgtga tggcacttgt ctacatctgg cttcactcgc    780

tcatcggctg cctgccaccc ctgtttggtt ggtcatccgt ggagtttgac gagttcaaat    840

ggatgtgtgt ggctgcttgg caccgggagc ctggctacac ggccttctgg cagatctggt    900

gtgccctctt cccctttctg gtcatgctgg tgtgctatgg cttcatcttc cgcgtggcca    960

gggtcaaggc acgcaaggtg cactgtggca cagtcgtcat cgtggaggag gatgctcaga   1020

ggaccgggag gaagaactcc agcacctcca cctcctcttc aggcagcagg aggaatgcct   1080

ttcagggtgt ggtctactcg gccaaccagt gcaaagccct catcaccatc ctggtggtcc   1140

tcggtgcctt catggtcacc tggggcccct acatggttgt catcgcctct gaggccctct   1200

gggggaaaag ctccgtctcc ccgagcctgg agacttgggc cacatggctg tcctttgcca   1260

gcgctgtctg ccaccccctg atctatggac tctggaacaa gacagttcgc aaagaactac   1320

tgggcatgtg ctttggggac cggtattatc gggaaccatt tgtgcaacga cagaggactt   1380

ccaggctctt cagcatttcc aacaggatca cagacctggg cctgtcccca cacctcactg   1440

cgctcatggc aggtggacag cccctggggc acagcagcag cacgggggac actggcttca   1500

gctgctccca ggactcaggg acagatatga tgctgcttga ggactacacg tctgatgaca   1560

accctccctc tcactgcact tgcccaccca agagaaggag ctcggtgaca tttgaggatg   1620

aagtggaaca aatcaaagaa gctgccaaga actcgattct tcatgtgaaa gctgaagtac   1680

acaagtcctt ggacagttac gcagcaagct tggccaaagc cattgaggcc gaagccaaaa   1740

tcaacttatt tggggaggag gctttgccag gggtcttggt tacagcacgg actgtcccgg   1800

ggggcggctt cgggggccgc cgaggcagca gaactcttgt gagccagagg ctgcagttgc   1860

agagcatcga agaaggagat gttttagctg ccgagcagag atgagggcct cagggtgccg   1920

tggggctgca gcctgagagg ctggcccggg gaggagttcc catcaccgcc tgtgccgcgg   1980

ccttgggagc atgtcactgt gtacagctgg ccacacacag ggaaggagca gcatctggta   2040

tgcagccacc aggacaagga ctgaaaataa tgtctacagt ccacagcttc agcatttcca   2100

gagaccacat gtgagcttct tttaggtccc agtgatggga ccagaagcat ctaaagcaaa   2160

aaaaaaacca aaaaaaaatc tagagatgtg gctgtggctt tttgggaggt ggggcatggg   2220

aggaccagag acgaagggct tggaaggaga cccccacatg catcatttcc tcctcttcac   2280

agtgtgctgg gagtccagcc gtgcactgtg ccagatgcct caggaggaga accctcccca   2340

gtgtactgtg aaggatgaca cagcacttct tcctaatgac acgcgaccgt cctggtgcct   2400

ctacatggtt gatgcgggca gtgtgggacc ctcagttcta ggactggtcc gcagagaaag   2460

cacccaggag cagagcgctt cggagcggtc ctcagtggcg ccacctgctg gtgctaatag   2520

ggacagccac aggcctcttg cagactggcc caccctgcct acttccctac tgacaagttc   2580

tttggtattt caaaagggag aaaccactat aaaagacaag aggaagggca ggtactaggt   2640

gtttcatttc cagaattaaa aaaaaaatcc atttaaaaaa aaaaaaaaaa aaaaaaaaaa   2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                2733


<210>  152
<211>  529
<212>  PRT
<213>  Homosapiens

<400>  152

Met Ser Leu Asn Ser Ser Leu Ser Cys Arg Lys Glu Leu Ser Asn Leu 
1               5                   10                  15      


Thr Glu Glu Glu Gly Gly Glu Gly Gly Val Ile Ile Thr Gln Phe Ile 
            20                  25                  30          


Ala Ile Ile Val Ile Thr Ile Phe Val Cys Leu Gly Asn Leu Val Ile 
        35                  40                  45              


Val Val Thr Leu Tyr Lys Lys Ser Tyr Leu Leu Thr Leu Ser Asn Lys 
    50                  55                  60                  


Phe Val Phe Ser Leu Thr Leu Ser Asn Phe Leu Leu Ser Val Leu Val 
65                  70                  75                  80  


Leu Pro Phe Val Val Thr Ser Ser Ile Arg Arg Glu Trp Ile Phe Gly 
                85                  90                  95      


Val Val Trp Cys Asn Phe Ser Ala Leu Leu Tyr Leu Leu Ile Ser Ser 
            100                 105                 110         


Ala Ser Met Leu Thr Leu Gly Val Ile Ala Ile Asp Arg Tyr Tyr Ala 
        115                 120                 125             


Val Leu Tyr Pro Met Val Tyr Pro Met Lys Ile Thr Gly Asn Arg Ala 
    130                 135                 140                 


Val Met Ala Leu Val Tyr Ile Trp Leu His Ser Leu Ile Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Leu Phe Gly Trp Ser Ser Val Glu Phe Asp Glu Phe Lys Trp 
                165                 170                 175     


Met Cys Val Ala Ala Trp His Arg Glu Pro Gly Tyr Thr Ala Phe Trp 
            180                 185                 190         


Gln Ile Trp Cys Ala Leu Phe Pro Phe Leu Val Met Leu Val Cys Tyr 
        195                 200                 205             


Gly Phe Ile Phe Arg Val Ala Arg Val Lys Ala Arg Lys Val His Cys 
    210                 215                 220                 


Gly Thr Val Val Ile Val Glu Glu Asp Ala Gln Arg Thr Gly Arg Lys 
225                 230                 235                 240 


Asn Ser Ser Thr Ser Thr Ser Ser Ser Gly Ser Arg Arg Asn Ala Phe 
                245                 250                 255     


Gln Gly Val Val Tyr Ser Ala Asn Gln Cys Lys Ala Leu Ile Thr Ile 
            260                 265                 270         


Leu Val Val Leu Gly Ala Phe Met Val Thr Trp Gly Pro Tyr Met Val 
        275                 280                 285             


Val Ile Ala Ser Glu Ala Leu Trp Gly Lys Ser Ser Val Ser Pro Ser 
    290                 295                 300                 


Leu Glu Thr Trp Ala Thr Trp Leu Ser Phe Ala Ser Ala Val Cys His 
305                 310                 315                 320 


Pro Leu Ile Tyr Gly Leu Trp Asn Lys Thr Val Arg Lys Glu Leu Leu 
                325                 330                 335     


Gly Met Cys Phe Gly Asp Arg Tyr Tyr Arg Glu Pro Phe Val Gln Arg 
            340                 345                 350         


Gln Arg Thr Ser Arg Leu Phe Ser Ile Ser Asn Arg Ile Thr Asp Leu 
        355                 360                 365             


Gly Leu Ser Pro His Leu Thr Ala Leu Met Ala Gly Gly Gln Pro Leu 
    370                 375                 380                 


Gly His Ser Ser Ser Thr Gly Asp Thr Gly Phe Ser Cys Ser Gln Asp 
385                 390                 395                 400 


Ser Gly Thr Asp Met Met Leu Leu Glu Asp Tyr Thr Ser Asp Asp Asn 
                405                 410                 415     


Pro Pro Ser His Cys Thr Cys Pro Pro Lys Arg Arg Ser Ser Val Thr 
            420                 425                 430         


Phe Glu Asp Glu Val Glu Gln Ile Lys Glu Ala Ala Lys Asn Ser Ile 
        435                 440                 445             


Leu His Val Lys Ala Glu Val His Lys Ser Leu Asp Ser Tyr Ala Ala 
    450                 455                 460                 


Ser Leu Ala Lys Ala Ile Glu Ala Glu Ala Lys Ile Asn Leu Phe Gly 
465                 470                 475                 480 


Glu Glu Ala Leu Pro Gly Val Leu Val Thr Ala Arg Thr Val Pro Gly 
                485                 490                 495     


Gly Gly Phe Gly Gly Arg Arg Gly Ser Arg Thr Leu Val Ser Gln Arg 
            500                 505                 510         


Leu Gln Leu Gln Ser Ile Glu Glu Gly Asp Val Leu Ala Ala Glu Gln 
        515                 520                 525             


Arg 
    


<210>  153
<211>  854
<212>  DNA
<213>  Homosapiens

<400>  153
gggtcggccg gcagggggcg gggccgggca tggtaacggc tcggaagcct aggaggctgg     60

gccggaggga ggcggaggaa ccggtgttcg ccgccgccgc tgcttcagct tattccttgt    120

ggcctctgcg ggtcctgcct cagccatgat gatccacggc ttccagagca gccaccggga    180

tttctgcttc gggccctgga agctgacggc gtccaagacc cacatcatga agtcggcgga    240

tgtggagaaa ttagccgatg aattacatat gccatctctc cctgaaatga tgtttggaga    300

caacgtttta agaatccagc atgggtctgg ctttggaatt gagttcaatg ctacagatgc    360

gttaagatgt gtaaacaact accaaggaat gcttaaagtg gcctgtgctg aagagtggca    420

agaaagcagg acggagggtg aacactccaa agaggttatt aaaccatatg attggaccta    480

tacaacagat tataagggaa ccttacttgg agaatctctt aagttaaagg ttgtacctac    540

aacagatcat atagatacag aaaaattgaa agccagagaa cagattaagt tttttgaaga    600

agttctcctt tttgaggatg aacttcatga tcatggagtt tcaagcctga gtgtgaagat    660

tcctggtggc gggcacctgt agtcccagct actcgggagg ctgaggcagg agaagcgtga    720

acccgggagg cggagcttgc agtgagctga gatcgcacca ctgcactcca gccctccagc    780

ctgggcgaca gagcaagact ccgtctcaaa aaaaaaaaat aaaataaaat aaaagaagta    840

gaaaacacaa aaaa                                                      854


<210>  154
<211>  178
<212>  PRT
<213>  Homosapiens

<400>  154

Met Met Ile His Gly Phe Gln Ser Ser His Arg Asp Phe Cys Phe Gly 
1               5                   10                  15      


Pro Trp Lys Leu Thr Ala Ser Lys Thr His Ile Met Lys Ser Ala Asp 
            20                  25                  30          


Val Glu Lys Leu Ala Asp Glu Leu His Met Pro Ser Leu Pro Glu Met 
        35                  40                  45              


Met Phe Gly Asp Asn Val Leu Arg Ile Gln His Gly Ser Gly Phe Gly 
    50                  55                  60                  


Ile Glu Phe Asn Ala Thr Asp Ala Leu Arg Cys Val Asn Asn Tyr Gln 
65                  70                  75                  80  


Gly Met Leu Lys Val Ala Cys Ala Glu Glu Trp Gln Glu Ser Arg Thr 
                85                  90                  95      


Glu Gly Glu His Ser Lys Glu Val Ile Lys Pro Tyr Asp Trp Thr Tyr 
            100                 105                 110         


Thr Thr Asp Tyr Lys Gly Thr Leu Leu Gly Glu Ser Leu Lys Leu Lys 
        115                 120                 125             


Val Val Pro Thr Thr Asp His Ile Asp Thr Glu Lys Leu Lys Ala Arg 
    130                 135                 140                 


Glu Gln Ile Lys Phe Phe Glu Glu Val Leu Leu Phe Glu Asp Glu Leu 
145                 150                 155                 160 


His Asp His Gly Val Ser Ser Leu Ser Val Lys Ile Pro Gly Gly Gly 
                165                 170                 175     


His Leu 
        


<210>  155
<211>  3032
<212>  DNA
<213>  Homosapiens

<400>  155
gggtcggccg gcagggggcg gggccgggca tggtaacggc tcggaagcct aggaggctgg     60

gccggaggga ggcggaggaa ccggtgttcg ccgccgccgc tgcttcagct tattccttgt    120

ggcctctgcg ggtcctgcct cagccatgat gatccacggc ttccagagca gccaccggga    180

tttctgcttc gggccctgga agctgacggc gtccaagacc cacatcatga agtcggcgga    240

tgtggagaaa ttagccgatg aattacatat gccatctctc cctgaaatga tgtttggaga    300

caacgtttta agaatccagc atgggtctgg ctttggaatt gagttcaatg ctacagatgc    360

gttaagatgt gtaaacaact accaaggaat gcttaaagtg gcctgtgctg aagagtggca    420

agaaagcagg acggagggtg aacactccaa agaggttatt aaaccatatg attggaccta    480

tacaacagat tataagggaa ccttacttgg agaatctctt aagttaaagg ttgtacctac    540

aacagatcat atagatacag aaaaattgaa agccagagaa cagattaagt tttttgaaga    600

agttctcctt tttgaggatg aacttcatga tcatggagtt tcaagcctga gtgtgaagat    660

tagagtaatg ccttctagct ttttcctgct gttgcggttt ttcttgagaa ttgatggggt    720

gcttatcaga atgaatgaca cgagacttta ccatgaggct gacaagacct acatgttacg    780

agaatatacg tcacgagaaa gcaaaatttc tagtttgatg catgttccac cttccctctt    840

cacggaacct aatgaaatat cccagtattt accaataaag gaagcagttt gtgagaagct    900

aatatttcca gaaagaattg atcctaaccc agcagactca caaaaaagta cacaagtgga    960

ataaaatgtg atacaacata tactcactat ggaatctgac tggacacctt ggctatttgt   1020

aaggggttat ttttattatg agaattaatt gccttgttta tgtacagatt ttctgtagcc   1080

ttaaaggaaa aaaaaataaa gatcgttaca ggcaggtttc actcaactgc tgtttgtact   1140

gtctgtcttc acattcatat tccagattta tattttctgg agttaaattt ggatgatttc   1200

taaattatca caaagtggga cctcagcagt agtgatgtgt gtgtctcatg agcagtgagc   1260

acagtctgca ttcatcatga aacactatct tctaccagga ggaggttaat gtaaatcacc   1320

aaatcccaat gccttgtgac tttcatagga ttcctgatca tgcatgttga tgtactggct   1380

cttcactttg ggctttctga tgtttattca cacctttgga gagttgcaac ttgccacata   1440

cgaaattagt ctcatagtgt agtgaacttc aaccccaaaa ttttaaaaat gtatttcccc   1500

ccagttttaa attgcctttg aaatttaaaa aaaaaaaatt tagacttagt accagaacca   1560

aaaataccta gatttttgga gaacttatta catacataga aacatgaata tggtttacca   1620

ctgtgtgtgt gtaggatgtt agaattatct gtcctccatc tttaggtgct ttttcttaaa   1680

tgtggttcta cttatactga tatttttaat ttccatcttc catgcaacct cagagtgaat   1740

aaacccctta aatttggtgc tggttcgaaa aagtctaaag ggtttattag gggttgtttt   1800

tcgcaaatat tacatcaatc cttaaagcaa caagattaat tttctgctta aaatatttgg   1860

gaagataggt aaggaggagg gggttttaaa atataaaagc aagtttttct attttaaggt   1920

gcatatttgt aacattacag gggatgaagt aaaatgtaat taattagcac aagacttagg   1980

gagtacagaa aatacacaga agtaaatttc aaatccattt gattgttttc atagtgaccc   2040

cttagtcatt ttatattctt gtctgccttt ctagaaaaat ggttgtcata aagtggaaag   2100

tgattaaaaa gcatcaaata agaaattatt tcaagtggat ttttaaaaat atttttttga   2160

agggcagggg gaaaattcac cccttttctg atttgaaata tgttgtacat atttccattt   2220

gatggataaa tcattaagta agaatatttg atttaaagta ttagccaacc tcttcaggta   2280

ttagcctgaa gataaatttt aacaaaacat atacacttgg gtatccgtca ttgctcaaac   2340

tctatagtgt attgctggag ccaataggca gggtatattt tattagctaa atttgatatt   2400

tgtcttctgc cttctgtatc acctccaagc tataggaaat caggattttg ttggctttaa   2460

gaaaacacat ggtatgttca ctgtatatta aatatacctg tatttaatgt tttctcttag   2520

gacagaaaag tagacacaca cacacacaca cacacacatg ttgtgttcag ctttctgttt   2580

tatattattt gccattgaga ttagaataga acaggctcta ttcatgcaaa ctatatgaaa   2640

tgaaaaactt ttaagactct tcattaattg gagcttctgg gcaacatcgt gtgtgtgtgt   2700

gtgtgtgtgt gtgtgtgtgt gtgtatacag acattttttt tttaacttgt tgattcagat   2760

gtcttggtcc ctgaatagtc ctagattact tattttgaga attcattgtt aaaaattaca   2820

gggaattaaa ataattgcct tttttttttt tagagggtaa gagatgggta gaagagtatg   2880

cctctgaaaa ttttattagt ttattcttgt ggagaatacc aagaaaatgt gtatttgccc   2940

attgctaaat atgatatatg ccattttgta tttatttgtc ccaagtgtct ttttgtaaga   3000

ggagaataaa caataaggaa ttactgatca aa                                 3032


<210>  156
<211>  272
<212>  PRT
<213>  Homosapiens

<400>  156

Met Met Ile His Gly Phe Gln Ser Ser His Arg Asp Phe Cys Phe Gly 
1               5                   10                  15      


Pro Trp Lys Leu Thr Ala Ser Lys Thr His Ile Met Lys Ser Ala Asp 
            20                  25                  30          


Val Glu Lys Leu Ala Asp Glu Leu His Met Pro Ser Leu Pro Glu Met 
        35                  40                  45              


Met Phe Gly Asp Asn Val Leu Arg Ile Gln His Gly Ser Gly Phe Gly 
    50                  55                  60                  


Ile Glu Phe Asn Ala Thr Asp Ala Leu Arg Cys Val Asn Asn Tyr Gln 
65                  70                  75                  80  


Gly Met Leu Lys Val Ala Cys Ala Glu Glu Trp Gln Glu Ser Arg Thr 
                85                  90                  95      


Glu Gly Glu His Ser Lys Glu Val Ile Lys Pro Tyr Asp Trp Thr Tyr 
            100                 105                 110         


Thr Thr Asp Tyr Lys Gly Thr Leu Leu Gly Glu Ser Leu Lys Leu Lys 
        115                 120                 125             


Val Val Pro Thr Thr Asp His Ile Asp Thr Glu Lys Leu Lys Ala Arg 
    130                 135                 140                 


Glu Gln Ile Lys Phe Phe Glu Glu Val Leu Leu Phe Glu Asp Glu Leu 
145                 150                 155                 160 


His Asp His Gly Val Ser Ser Leu Ser Val Lys Ile Arg Val Met Pro 
                165                 170                 175     


Ser Ser Phe Phe Leu Leu Leu Arg Phe Phe Leu Arg Ile Asp Gly Val 
            180                 185                 190         


Leu Ile Arg Met Asn Asp Thr Arg Leu Tyr His Glu Ala Asp Lys Thr 
        195                 200                 205             


Tyr Met Leu Arg Glu Tyr Thr Ser Arg Glu Ser Lys Ile Ser Ser Leu 
    210                 215                 220                 


Met His Val Pro Pro Ser Leu Phe Thr Glu Pro Asn Glu Ile Ser Gln 
225                 230                 235                 240 


Tyr Leu Pro Ile Lys Glu Ala Val Cys Glu Lys Leu Ile Phe Pro Glu 
                245                 250                 255     


Arg Ile Asp Pro Asn Pro Ala Asp Ser Gln Lys Ser Thr Gln Val Glu 
            260                 265                 270         


<210>  157
<211>  1155
<212>  DNA
<213>  Homosapiens

<400>  157
ggaagagccg tcaacttagc gagcgcaaca ggctgccgct gaggagctgg agctggtggg     60

gactgggccg caatggacaa gctgaagaag gtgctgagcg ggcaggacac ggaggaccgg    120

agcggcctgt ccgaggttgt tgaggcatct tcattaagct ggagtaccag gataaaaggc    180

ttcattgcgt gttttgctat aggaattctc tgctcactgc tgggtactgt tctgctgtgg    240

gtgcccagga agggactaca cctcttcgca gtgttttata cctttggtaa tatcgcatca    300

attgggagta ccatcttcct catgggacca gtgaaacagc tgaagcgaat gtttgagcct    360

actcgtttga ttgcaactat catggtgctg ttgtgttttg cacttaccct gtgttctgcc    420

ttttggtggc ataacaaggg acttgcactt atcttctgca ttttgcagtc tttggcattg    480

acgtggtaca gcctttcctt cataccattt gcaagggatg ctgtgaagaa gtgttttgcc    540

gtgtgtcttg cataattcat ggccagtttt atgaagcttt ggaaggcact atggacagaa    600

gctggtggac agttttgtaa ctatcttcga aacctctgtc ttacagacat gtgcctttta    660

tcttgcagca atgtgttgct tgtgattcga acatttgagg gttacttttg gaagcaacaa    720

tacattctcg aacctgaatg tcagtagcac aggatgagaa gtgggttctg tatcttgtgg    780

agtggaatct tcctcatgta cctgtttcct ctctggatgt tgtcccactg aattcccatg    840

aatacaaacc tattcagcaa cagcacataa gccttgggtg caagtgattc ccaggtggca    900

aaaggcagcc ccatcagaga tcacgggagc aacagtaagg gacagagttt tggggtccac    960

ttgtccctca gcatggaagc catcaccgtg gtcctgcata gagtgagtct gcttctactc   1020

tggcatctga gaacaagtga ctctgcttta gacaagcccc tggagagcct ggccatggag   1080

tgaggtagaa aagaagcact ttttggtggt atatgctgtt tctgaatttg aatctaagca   1140

ttcttggtgt tctga                                                    1155


<210>  158
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  158

Met Asp Lys Leu Lys Lys Val Leu Ser Gly Gln Asp Thr Glu Asp Arg 
1               5                   10                  15      


Ser Gly Leu Ser Glu Val Val Glu Ala Ser Ser Leu Ser Trp Ser Thr 
            20                  25                  30          


Arg Ile Lys Gly Phe Ile Ala Cys Phe Ala Ile Gly Ile Leu Cys Ser 
        35                  40                  45              


Leu Leu Gly Thr Val Leu Leu Trp Val Pro Arg Lys Gly Leu His Leu 
    50                  55                  60                  


Phe Ala Val Phe Tyr Thr Phe Gly Asn Ile Ala Ser Ile Gly Ser Thr 
65                  70                  75                  80  


Ile Phe Leu Met Gly Pro Val Lys Gln Leu Lys Arg Met Phe Glu Pro 
                85                  90                  95      


Thr Arg Leu Ile Ala Thr Ile Met Val Leu Leu Cys Phe Ala Leu Thr 
            100                 105                 110         


Leu Cys Ser Ala Phe Trp Trp His Asn Lys Gly Leu Ala Leu Ile Phe 
        115                 120                 125             


Cys Ile Leu Gln Ser Leu Ala Leu Thr Trp Tyr Ser Leu Ser Phe Ile 
    130                 135                 140                 


Pro Phe Ala Arg Asp Ala Val Lys Lys Cys Phe Ala Val Cys Leu Ala 
145                 150                 155                 160 


<210>  159
<211>  1065
<212>  DNA
<213>  Homosapiens

<400>  159
atgtggaatc agtgcttact aggcagccag acgggcagca ttaaagcttt ggggacgtgg     60

gtgcttaagg agaagaaaca gccaaaagga aatgaaggag cattaaacag caacccagcc    120

atgtcacgtg actcacactc ctcctgcgcc agagcccagt gtgagcccct gtctgacagt    180

cagtcacaga ggacccagca gcaaggcatg attatcaaca gaaatcagct tagcaaaatg    240

cagctcaccc caccccctgt ggcgttgctg gaccactgca actgcaccgt ggatatgccc    300

atcctgaaag acctgaccac cgtggccttc tgtgatgcac agtccacgca ggaaatccac    360

cagaatgttt taaatgaagc cgtgggcgcc atgacgtacc acaaaatcac cttctccagg    420

gaggacctgg agaagttcaa ggccctaaga gtgactgttg cagataggca ctggccacga    480

caatgtggat ggacatcaag gctggctgtg agctcgggat tgctgtgtgc aacatccctt    540

ccgagccgag gaagaaacag ccgactccac catctgccac atcctcaatc tgtaccggag    600

gaaccgtggc tgtacgaggc gctgcgggaa ggcacgtggg gtgggacaga gcagtccctg    660

ggcctgcaga gggtctatgc cctgcaggat ttgctgtatc agagtgacca cctctccatg    720

cactgcagtt tcaaggaaca taaccacaac ctcaccaatg actttactgg tccgtttaaa    780

gatgcaagga attttatctg tattccccac actgcctggt acacgccttg gtcagtaata    840

gaccagcaag caattcatct cgagctcagt ggtgccacat acaggtatct gccaggcatc    900

gtgggtgtgg ctccaggagc actccctgca gccacggaag ggatcatcct tggaggcatc    960

ccagtgattc acaatctccc gacagtggta catccttccc aagctccctc tcccaaccag   1020

cccacaaaac acggagacaa tcgagagcac cccaacgcac aatag                   1065


<210>  160
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  160

Met Trp Asn Gln Cys Leu Leu Gly Ser Gln Thr Gly Ser Ile Lys Ala 
1               5                   10                  15      


Leu Gly Thr Trp Val Leu Lys Glu Lys Lys Gln Pro Lys Gly Asn Glu 
            20                  25                  30          


Gly Ala Leu Asn Ser Asn Pro Ala Met Ser Arg Asp Ser His Ser Ser 
        35                  40                  45              


Cys Ala Arg Ala Gln Cys Glu Pro Leu Ser Asp Ser Gln Ser Gln Arg 
    50                  55                  60                  


Thr Gln Gln Gln Gly Met Ile Ile Asn Arg Asn Gln Leu Ser Lys Met 
65                  70                  75                  80  


Gln Leu Thr Pro Pro Pro Val Ala Leu Leu Asp His Cys Asn Cys Thr 
                85                  90                  95      


Val Asp Met Pro Ile Leu Lys Asp Leu Thr Thr Val Ala Phe Cys Asp 
            100                 105                 110         


Ala Gln Ser Thr Gln Glu Ile His Gln Asn Val Leu Asn Glu Ala Val 
        115                 120                 125             


Gly Ala Met Thr Tyr His Lys Ile Thr Phe Ser Arg Glu Asp Leu Glu 
    130                 135                 140                 


Lys Phe Lys Ala Leu Arg Val Thr Val Ala Asp Arg His Trp Pro Arg 
145                 150                 155                 160 


Gln Cys Gly Trp Thr Ser Arg Leu Ala Val Ser Ser Gly Leu Leu Cys 
                165                 170                 175     


Ala Thr Ser Leu Pro Ser Arg Gly Arg Asn Ser Arg Leu His His Leu 
            180                 185                 190         


Pro His Pro Gln Ser Val Pro Glu Glu Pro Trp Leu Tyr Glu Ala Leu 
        195                 200                 205             


Arg Glu Gly Thr Trp Gly Gly Thr Glu Gln Ser Leu Gly Leu Gln Arg 
    210                 215                 220                 


Val Tyr Ala Leu Gln Asp Leu Leu Tyr Gln Ser Asp His Leu Ser Met 
225                 230                 235                 240 


His Cys Ser Phe Lys Glu His Asn His Asn Leu Thr Asn Asp Phe Thr 
                245                 250                 255     


Gly Pro Phe Lys Asp Ala Arg Asn Phe Ile Cys Ile Pro His Thr Ala 
            260                 265                 270         


Trp Tyr Thr Pro Trp Ser Val Ile Asp Gln Gln Ala Ile His Leu Glu 
        275                 280                 285             


Leu Ser Gly Ala Thr Tyr Arg Tyr Leu Pro Gly Ile Val Gly Val Ala 
    290                 295                 300                 


Pro Gly Ala Leu Pro Ala Ala Thr Glu Gly Ile Ile Leu Gly Gly Ile 
305                 310                 315                 320 


Pro Val Ile His Asn Leu Pro Thr Val Val His Pro Ser Gln Ala Pro 
                325                 330                 335     


Ser Pro Asn Gln Pro Thr Lys His Gly Asp Asn Arg Glu His Pro Asn 
            340                 345                 350         


Ala Gln 
        


<210>  161
<211>  2382
<212>  DNA
<213>  Homosapiens

<400>  161
tgtggagctt ctgagatctg tggaggtttt tctctgcaaa tgcaggaaga aatcaggtgg     60

atggatgcat aattatggcc ctgctcctgg tctctttgct ggcattcctg agcttgggct    120

caggatgtca tcatcggatc tgtcactgct ctaacagggt ttttctctgc caagagagca    180

aggtgacaga gattccttct gacctcccga ggaatgccat tgaactgagg tttgtcctca    240

ccaagcttcg agtcatccaa aaaggtgcat tttcaggatt tggggacctg gagaaaatag    300

agatctctca gaatgatgtc ttggaggtga tagaggcaga tgtgttctcc aaccttccca    360

aattacatga aattagaatt gaaaaggcca acaacctgct ctacatcaac cctgaggcct    420

tccagaacct tcccaacctt caatatctgt taatatccaa cacaggtatt aagcaccttc    480

cagatgttca caagattcat tctctccaaa aagttttact tgacattcaa gataacataa    540

acatccacac aattgaaaga aattctttcg tggggctgag ctttgaaagt gtgattctat    600

ggctgaataa gaatgggatt caagaaatac acaactgtgc attcaatgga acccaactag    660

atgagctgaa tctaagcgat aataataatt tagaagaatt gcctaatgat gttttccacg    720

gagcctctgg accagtcatt ctagatattt caagaacaag gatccattcc ctgcctagct    780

atggcttaga aaatcttaag aagctgaggg ccaggtcgac ttacaactta aaaaagctgc    840

ctactctgga aaagcttgtc gccctcatgg aagccagcct cacctatccc agccattgct    900

gtgcctttgc aaactggaga cggcaaatct ctgagcttca tccaatttgc aacaaatcta    960

ttttaaggca agaagttgat tatatgactc aggctagggg tcagagatcc tctctggcag   1020

aagacaatga gtccagctac agcagaggat ttgacatgac gtacactgag tttgactatg   1080

acttatgcaa tgaagtggtt gacgtgacct gctcccctaa gccagatgca ttcaacccat   1140

gtgaagatat catggggtac aacatcctca gagtcctgat atggtttatc agcatcctgg   1200

ccatcactgg gaacatcata gtgctagtga tcctaactac cagccaatat aaactcacag   1260

tccccaggtt ccttatgtgc aacctggcct ttgctgatct ctgcattgga atctacctgc   1320

tgctcattgc atcagttgat atccatacca agagccaata tcacaactat gccattgact   1380

ggcaaactgg ggcaggctgt gatgctgctg gctttttcac tgtctttgcc agtgagctgt   1440

cagtctacac tctgacagct atcaccttgg aaagatggca taccatcacg catgccatgc   1500

agctggactg caaggtgcag ctccgccatg ctgccagtgt catggtgatg ggctggattt   1560

ttgcttttgc agctgccctc tttcccatct ttggcatcag cagctacatg aaggtgagca   1620

tctgcctgcc catggatatt gacagccctt tgtcacagct gtatgtcatg tccctccttg   1680

tgctcaatgt cctggccttt gtggtcatct gtggctgcta tatccacatc tacctcacag   1740

tgcggaaccc caacatcgtg tcctcctcta gtgacaccag gatcgccaag cgcatggcca   1800

tgctcatctt cactgacttc ctctgcatgg cacccatttc tttctttgcc atttctgcct   1860

ccctcaaggt gcccctcatc actgtgtcca aagcaaagat tctgctggtt ctgtttcacc   1920

ccatcaactc ctgtgccaac cccttcctct atgccatctt taccaaaaac tttcgcagag   1980

atttcttcat tctgctgagc aagtgtggct gctatgaaat gcaagcccaa atttatagga   2040

cagaaacttc atccactgtc cacaacaccc atccaaggaa tggccactgc tcttcagctc   2100

ccagagtcac cagtggttcc acttacatac ttgtccctct aagtcattta gcccaaaact   2160

aaaacacaat gtgaaaatgt atctgagtat tgaatgataa ttcagtcttg cctttgaagg   2220

gtatgtcaca aagagctgac agtgcttcta cacatttcat ctaatttaat attcctggca   2280

tacctttaag gtaaattggt caggaactat taattccatg tgatacatta ggaagctgaa   2340

ttattagtaa caacaataat aattaaagaa tgcaatactg ta                      2382


<210>  162
<211>  695
<212>  PRT
<213>  Homosapiens

<400>  162

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Asp 
    210                 215                 220                 


Ile Ser Arg Thr Arg Ile His Ser Leu Pro Ser Tyr Gly Leu Glu Asn 
225                 230                 235                 240 


Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr Asn Leu Lys Lys Leu Pro 
                245                 250                 255     


Thr Leu Glu Lys Leu Val Ala Leu Met Glu Ala Ser Leu Thr Tyr Pro 
            260                 265                 270         


Ser His Cys Cys Ala Phe Ala Asn Trp Arg Arg Gln Ile Ser Glu Leu 
        275                 280                 285             


His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met 
    290                 295                 300                 


Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser 
305                 310                 315                 320 


Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
                325                 330                 335     


Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala 
            340                 345                 350         


Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu 
        355                 360                 365             


Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
    370                 375                 380                 


Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe Leu 
385                 390                 395                 400 


Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr Leu Leu 
                405                 410                 415     


Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His Asn Tyr 
            420                 425                 430         


Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly Phe Phe 
        435                 440                 445             


Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala Ile Thr 
    450                 455                 460                 


Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp Cys Lys 
465                 470                 475                 480 


Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp Ile Phe 
                485                 490                 495     


Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser Tyr Met 
            500                 505                 510         


Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu Ser Gln 
        515                 520                 525             


Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe Val Val 
    530                 535                 540                 


Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn Pro Asn 
545                 550                 555                 560 


Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met Ala Met 
                565                 570                 575     


Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe Phe Ala 
            580                 585                 590         


Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys Ala Lys 
        595                 600                 605             


Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn Pro Phe 
    610                 615                 620                 


Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr Arg Thr 
                645                 650                 655     


Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly His Cys 
            660                 665                 670         


Ser Ser Ala Pro Arg Val Thr Ser Gly Ser Thr Tyr Ile Leu Val Pro 
        675                 680                 685             


Leu Ser His Leu Ala Gln Asn 
    690                 695 


<210>  163
<211>  2196
<212>  DNA
<213>  Homosapiens

<400>  163
tgtggagctt ctgagatctg tggaggtttt tctctgcaaa tgcaggaaga aatcaggtgg     60

atggatgcat aattatggcc ctgctcctgg tctctttgct ggcattcctg agcttgggct    120

caggatgtca tcatcggatc tgtcactgct ctaacagggt ttttctctgc caagagagca    180

aggtgacaga gattccttct gacctcccga ggaatgccat tgaactgagg tttgtcctca    240

ccaagcttcg agtcatccaa aaaggtgcat tttcaggatt tggggacctg gagaaaatag    300

agatctctca gaatgatgtc ttggaggtga tagaggcaga tgtgttctcc aaccttccca    360

aattacatga aattagaatt gaaaaggcca acaacctgct ctacatcaac cctgaggcct    420

tccagaacct tcccaacctt caatatctgt taatatccaa cacaggtatt aagcaccttc    480

cagatgttca caagattcat tctctccaaa aagttttact tgacattcaa gataacataa    540

acatccacac aattgaaaga aattctttcg tggggctgag ctttgaaagt gtgattctat    600

ggctgaataa gaatgggatt caagaaatac acaactgtgc attcaatgga acccaactag    660

atgagctgaa tctaagcgat aataataatt tagaagaatt gcctaatgat gttttccacg    720

gagcctctgg accagtcatt ctctctgagc ttcatccaat ttgcaacaaa tctattttaa    780

ggcaagaagt tgattatatg actcaggcta ggggtcagag atcctctctg gcagaagaca    840

atgagtccag ctacagcaga ggatttgaca tgacgtacac tgagtttgac tatgacttat    900

gcaatgaagt ggttgacgtg acctgctccc ctaagccaga tgcattcaac ccatgtgaag    960

atatcatggg gtacaacatc ctcagagtcc tgatatggtt tatcagcatc ctggccatca   1020

ctgggaacat catagtgcta gtgatcctaa ctaccagcca atataaactc acagtcccca   1080

ggttccttat gtgcaacctg gcctttgctg atctctgcat tggaatctac ctgctgctca   1140

ttgcatcagt tgatatccat accaagagcc aatatcacaa ctatgccatt gactggcaaa   1200

ctggggcagg ctgtgatgct gctggctttt tcactgtctt tgccagtgag ctgtcagtct   1260

acactctgac agctatcacc ttggaaagat ggcataccat cacgcatgcc atgcagctgg   1320

actgcaaggt gcagctccgc catgctgcca gtgtcatggt gatgggctgg atttttgctt   1380

ttgcagctgc cctctttccc atctttggca tcagcagcta catgaaggtg agcatctgcc   1440

tgcccatgga tattgacagc cctttgtcac agctgtatgt catgtccctc cttgtgctca   1500

atgtcctggc ctttgtggtc atctgtggct gctatatcca catctacctc acagtgcgga   1560

accccaacat cgtgtcctcc tctagtgaca ccaggatcgc caagcgcatg gccatgctca   1620

tcttcactga cttcctctgc atggcaccca tttctttctt tgccatttct gcctccctca   1680

aggtgcccct catcactgtg tccaaagcaa agattctgct ggttctgttt caccccatca   1740

actcctgtgc caaccccttc ctctatgcca tctttaccaa aaactttcgc agagatttct   1800

tcattctgct gagcaagtgt ggctgctatg aaatgcaagc ccaaatttat aggacagaaa   1860

cttcatccac tgtccacaac acccatccaa ggaatggcca ctgctcttca gctcccagag   1920

tcaccagtgg ttccacttac atacttgtcc ctctaagtca tttagcccaa aactaaaaca   1980

caatgtgaaa atgtatctga gtattgaatg ataattcagt cttgcctttg aagggtatgt   2040

cacaaagagc tgacagtgct tctacacatt tcatctaatt taatattcct ggcatacctt   2100

taaggtaaat tggtcaggaa ctattaattc catgtgatac attaggaagc tgaattatta   2160

gtaacaacaa taataattaa agaatgcaat actgta                             2196


<210>  164
<211>  633
<212>  PRT
<213>  Homosapiens

<400>  164

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Ser 
    210                 215                 220                 


Glu Leu His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp 
225                 230                 235                 240 


Tyr Met Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn 
                245                 250                 255     


Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp 
            260                 265                 270         


Tyr Asp Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro 
        275                 280                 285             


Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg 
    290                 295                 300                 


Val Leu Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile 
305                 310                 315                 320 


Val Leu Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg 
                325                 330                 335     


Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr 
            340                 345                 350         


Leu Leu Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His 
        355                 360                 365             


Asn Tyr Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly 
    370                 375                 380                 


Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala 
385                 390                 395                 400 


Ile Thr Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp 
                405                 410                 415     


Cys Lys Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp 
            420                 425                 430         


Ile Phe Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser 
        435                 440                 445             


Tyr Met Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu 
    450                 455                 460                 


Ser Gln Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe 
465                 470                 475                 480 


Val Val Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn 
                485                 490                 495     


Pro Asn Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met 
            500                 505                 510         


Ala Met Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe 
        515                 520                 525             


Phe Ala Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys 
    530                 535                 540                 


Ala Lys Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn 
545                 550                 555                 560 


Pro Phe Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe 
                565                 570                 575     


Ile Leu Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr 
            580                 585                 590         


Arg Thr Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly 
        595                 600                 605             


His Cys Ser Ser Ala Pro Arg Val Thr Ser Gly Ser Thr Tyr Ile Leu 
    610                 615                 620                 


Val Pro Leu Ser His Leu Ala Gln Asn 
625                 630             


<210>  165
<211>  1460
<212>  DNA
<213>  Homosapiens

<400>  165
gacggcctgg catacccact gcccacccca gtgactgctc ttctgcttca ggcctgctgg     60

cctcccagca ctgcctgccc ctccctgtcg ggggacatcg cctccacacc ggctggggaa    120

ggagcccagg ggtggggctg gtgggtgggg ctggtggttg gggcagccag agaagtaaga    180

gggaagtgag aagccgggtg gggcaggctg gaaggaagac gaacctacga agcagagatc    240

tgaagacagc atgtacacag ccattcccca gagtggctct ccattcccag gctcagtgca    300

ggatccaggc ctgcatgtgt ggcgggtgga gaagctgaag ccggtgcctg tggcgcaaga    360

gaaccagggc gtcttcttct cgggggactc ctacctagtg ctgcacaatg gcccagaaga    420

ggtttcccat ctgcacctgt ggataggcca gcagtcatcc cgggatgagc agggggcctg    480

tgccgtgctg gctgtgcacc tcaacacgct gctgggagag cggcctgtgc agcaccgcga    540

ggtgcagggc aatgagtctg acctcttcat gagctacttc ccacggggcc tcaagtacca    600

ggaaggtggt gtggagtcag catttcacaa gacctccaca ggagccccag ctgccatcaa    660

gaaactctac caggtgaagg ggaagaagaa catccgtgcc accgagcggg cactgaactg    720

ggacagcttc aacactgggg actgcttcat cctggacctg ggccagaaca tcttcgcctg    780

gtgtggtgga aagtccaaca tcctggaacg caacaaggcg agggacctgg ccctggccat    840

ccgggacagt gagcgacagg gcaaggccca ggtggagatt gtcactgatg gggaggagcc    900

tgctgagatg atccaggtcc tgggccccaa gcctgctctg aaggagggca accctgagga    960

agacctcaca gctgacaagg caaatgccca ggccgcagct ctgtataagg tctctgatgc   1020

cactggacag atgaacctga ccaaggtggc tgactccagc ccatttgccc ttgaactgct   1080

gatatctgat gactgctttg tgctggacaa cgggctctgt ggcaagatct atatctggaa   1140

ggggcgaaaa gcgaatgaga aggagcggca ggcagccctg caggtggccg agggcttcat   1200

ctcgcgcatg cagtacgccc cgaacactca ggtggagatt ctgcctcagg gccatgagag   1260

tcccatcttc aagcaatttt tcaaggactg gaaatgaggg tgggcgtctt cctgccccat   1320

gctcccctgc cccccaccac ctgcctgctt gcttctctgg ctgcctggtc agtgcagagg   1380

tgccccctgc agatgttcaa taaaggagac aagtgctttc ccagctcttt tcctgcacca   1440

ccaaaaaaaa aaaaaaaaaa                                               1460


<210>  166
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  166

Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val 
1               5                   10                  15      


Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val 
            20                  25                  30          


Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr 
        35                  40                  45              


Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp 
    50                  55                  60                  


Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu 
65                  70                  75                  80  


Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg 
                85                  90                  95      


Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg 
            100                 105                 110         


Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr 
        115                 120                 125             


Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly 
    130                 135                 140                 


Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe 
145                 150                 155                 160 


Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala 
                165                 170                 175     


Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp 
            180                 185                 190         


Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val 
        195                 200                 205             


Glu Ile Val Thr Asp Gly Glu Glu Pro Ala Glu Met Ile Gln Val Leu 
    210                 215                 220                 


Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu Thr 
225                 230                 235                 240 


Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser Asp 
                245                 250                 255     


Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro Phe 
            260                 265                 270         


Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn Gly 
        275                 280                 285             


Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu Lys 
    290                 295                 300                 


Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg Met 
305                 310                 315                 320 


Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly His Glu 
                325                 330                 335     


Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys 
            340                 345             


<210>  167
<211>  909
<212>  DNA
<213>  Homosapiens

<400>  167
ggcattttcc ggtgcctgca ccaaatcagg aagctcctag tctgtgcccc aagatcacgc     60

ctcatttgga ggtcacacga ggcctggctg gtgggtcctg ccagggcact ggatctggag    120

agtggaggaa gcactgggtg ccggggtttg ggctcggggc catgtacgcc tcctcctacc    180

ccccaccccc gcagctgtcc cctagaagcc acctttgccc acccccaccc caccccaccc    240

caccccagct caataatctg cttcttctag aaggaaggaa atcgtctctt ccctctgtag    300

cccccactgg gagtgcctca gctgctgagg acagtgatct gctgactcag ccttggtact    360

cggggaactg tgaccgctat gctgttgaga gtgccctgct ccacttacaa aaggatgggg    420

cctataccgt gcgccccagc tcagggcctc atggctccca gcccttcacc ctggcagtgc    480

ttctccgagg ccgggtcttc aacattccca tccggcggct ggatggcgga cgccactatg    540

ccctgggccg ggagggcagg aaccgtgagg agctcttctc ctccgtggcg gccatggtcc    600

agcacttcat gtggcaccct ctgccccttg tggacagaca cagcggcagc cgggaactca    660

cctgcctgct cttccccacc aagccttgag gccacagcga agaatgcagg tgtctgccca    720

gttcactagg tcctggatga aggaaccgtg gtggcctaga ccagtcaggg gacagcacag    780

gcactgctgg aacagcaaag gatcctctca catctacttg tgggcctagg gcaccctgag    840

agggactggc ctaccttgca caagttcaca ttcaataaac atttgttgat tgaaaaaaaa    900

aaaaaaaaa                                                            909


<210>  168
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  168

Met Tyr Ala Ser Ser Tyr Pro Pro Pro Pro Gln Leu Ser Pro Arg Ser 
1               5                   10                  15      


His Leu Cys Pro Pro Pro Pro His Pro Thr Pro Pro Gln Leu Asn Asn 
            20                  25                  30          


Leu Leu Leu Leu Glu Gly Arg Lys Ser Ser Leu Pro Ser Val Ala Pro 
        35                  40                  45              


Thr Gly Ser Ala Ser Ala Ala Glu Asp Ser Asp Leu Leu Thr Gln Pro 
    50                  55                  60                  


Trp Tyr Ser Gly Asn Cys Asp Arg Tyr Ala Val Glu Ser Ala Leu Leu 
65                  70                  75                  80  


His Leu Gln Lys Asp Gly Ala Tyr Thr Val Arg Pro Ser Ser Gly Pro 
                85                  90                  95      


His Gly Ser Gln Pro Phe Thr Leu Ala Val Leu Leu Arg Gly Arg Val 
            100                 105                 110         


Phe Asn Ile Pro Ile Arg Arg Leu Asp Gly Gly Arg His Tyr Ala Leu 
        115                 120                 125             


Gly Arg Glu Gly Arg Asn Arg Glu Glu Leu Phe Ser Ser Val Ala Ala 
    130                 135                 140                 


Met Val Gln His Phe Met Trp His Pro Leu Pro Leu Val Asp Arg His 
145                 150                 155                 160 


Ser Gly Ser Arg Glu Leu Thr Cys Leu Leu Phe Pro Thr Lys Pro 
                165                 170                 175 


<210>  169
<211>  2002
<212>  DNA
<213>  Homosapiens

<400>  169
gttggggccg tgggagatga agatggtggg tggggggttg ggcccacagc ctgctaagca     60

ggcagagtgg cctcctgaac ccttcctcca tcgcctagag caaactccca ttcctggaag    120

gaggagcagc ccagaccctg agactggact aggtctgtta gggtccctgt gtggccggca    180

ggactcgtgg tgaagcccgg ggaaggcctg ggtcctccag gtcagggatg taggtcccag    240

ggtgtgcagg ccgcggtatc tgaccatcgt cggcgccctg cgcccaggca tcaattttac    300

atggcagagt caagaatgcc ctcttggtcg agtgcagtgg ctcacacctg tgatcccaac    360

actttgggag gctgaggcag gaggattgct tgagcccaga agttcaagac cagcctggac    420

aacatagaca cagaatggtc tgcctgggcc tcagtcacat tggaggagca gagagagaag    480

gagccatgag gagtcactca agggttttag gcagagccgt gacacaacca gagatactac    540

gagcaaaggt tccggaacag ggcagggcag gacaggtttg agagcaatgg cgcgatttcg    600

gctcacagca acctccgcct cctgggttca agctattctc ctgcctcaac aacctcctga    660

gggctgggat tacagacaag aggccatgtg aggacacaga gaaagcagcc gtttacaagc    720

caagaagaga ggccgcatca caaaccaacc tttatggcac cttgatctta gacttctagc    780

tccagaacag agatgcaaat ggtgggaaca atggagccct tgtccccagg ccatttgtgg    840

cagatcctgg gctccaggga ggcaaagctc ctctgcctct gccatggaca agctcagtgg    900

gagcaggccc cggctggggc caccgctccc accccccaga tgtgtggact ccccaggttg    960

gagagaagat gctcccagcc cttccttcct gcctgcccca gggacttgga gacacaaggc   1020

ccaggaggag gacgaggagg aaaataagta tgagctgccc ccccgtgagg ctctgcccct   1080

cagtctagcc cctgcccacc ttcctggcac tgaggaggac tccttgtacc tggatcactc   1140

tggccccctg ggtccatcaa agccatcgcc acccctgcct cagcccacca tgagcagggt   1200

gcatcgtcca gagtggtgcc aggccctcca aagaaacctg atgaggacct ctacttggaa   1260

tgtgagccgg atccagtcct ggctttgact cagactctca gcttccaagt cctgatgccc   1320

tcaggccctc tgcccaggac atcagtggtg cccaggccta ccacagcccc ccaggaaact   1380

cggaatggaa cagcagatgc tgcctctaaa gaaggaagga aatcgtctct tccctctgta   1440

gcccccactg ggagtgcctc agctgctgag gatggggcct ataccgtgcg ccccagctca   1500

gggcctcatg gctcccagcc cttcaccctg gcagtgcttc tccgaggccg ggtcttcaac   1560

actcccatcc ggcggctgga tggcggacgc cactatgccc tgggccggga gggcaggaac   1620

cgtgaggagc tcttctcctc cgtggcggcc atggtccagc acttcatgtg gcaccctctg   1680

ccccttgtgg acagacacag cggcagccgg gaactcacct gcctgctctt ccccaccaag   1740

ccttgaggcc acagcgaagc tgacaccctc ttcctggcct ccaggaatgc aggtgtctgc   1800

ccagttcact aggtcctgga tgaaggaacc gtggtggcct agaccagtca ggggacagca   1860

caggcactgc tggaacagca aaggatcctc tcacatctac ttgtgggcct agggcaccct   1920

gagagggact ggcctacctt gcacaagttc acattcaata aacatttgtt gaatgaaaaa   1980

aaaaaaaaaa aaaaaaaaaa aa                                            2002


<210>  170
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  170

Met Pro Ser Gly Pro Leu Pro Arg Thr Ser Val Val Pro Arg Pro Thr 
1               5                   10                  15      


Thr Ala Pro Gln Glu Thr Arg Asn Gly Thr Ala Asp Ala Ala Ser Lys 
            20                  25                  30          


Glu Gly Arg Lys Ser Ser Leu Pro Ser Val Ala Pro Thr Gly Ser Ala 
        35                  40                  45              


Ser Ala Ala Glu Asp Gly Ala Tyr Thr Val Arg Pro Ser Ser Gly Pro 
    50                  55                  60                  


His Gly Ser Gln Pro Phe Thr Leu Ala Val Leu Leu Arg Gly Arg Val 
65                  70                  75                  80  


Phe Asn Thr Pro Ile Arg Arg Leu Asp Gly Gly Arg His Tyr Ala Leu 
                85                  90                  95      


Gly Arg Glu Gly Arg Asn Arg Glu Glu Leu Phe Ser Ser Val Ala Ala 
            100                 105                 110         


Met Val Gln His Phe Met Trp His Pro Leu Pro Leu Val Asp Arg His 
        115                 120                 125             


Ser Gly Ser Arg Glu Leu Thr Cys Leu Leu Phe Pro Thr Lys Pro 
    130                 135                 140             


<210>  171
<211>  2835
<212>  DNA
<213>  Homosapiens

<400>  171
ttcgttcgct ccgcgccgcc cgcctgctac gagtagaacg ctgtccgcag cttgcgcatt     60

tcgcagccgc tgccgcctcg ccgctgctcc ttcgtaaggc cacttccgca caccgacacc    120

aacatgaacg gacagctcaa cggcttccac gaggcgttca tcgaggaggg cacattcctt    180

ttcacctcag agtcggtcgg ggaaggccac ccagataaga tttgtgacca aatcagtgat    240

gctgtccttg atgcccacct tcagcaggat cctgatgcca aagtagcttg tgaaactgtt    300

gctaaaactg gaatgatcct tcttgctggg gaaattacat ccagagctgc tgttgactac    360

cagaaagtgg ttcgtgaagc tgttaaacac attggatatg atgattcttc caaaggtttt    420

gactacaaga cttgtaacgt gctggtagcc ttggagcaac agtcaccaga tattgctcaa    480

ggtgttcatc ttgacagaaa tgaagaagac attggtgctg gagaccaggg cttaatgttt    540

ggctatgcca ctgatgaaac tgaggagtgt atgcctttaa ccattgtctt ggcacacaag    600

ctaaatgcca aactggcaga actacgccgt aatggcactt tgccttggtt acgccctgat    660

tctaaaactc aagttactgt gcagtatatg caggatcgag gtgctgtgct tcccatcaga    720

gtccacacaa ttgttatatc tgttcagcat gatgaagagg tttgtcttga tgaaatgagg    780

gatgccctaa aggagaaagt catcaaagca gttgtgcctg cgaaatacct tgatgaggat    840

acaatctacc acctacagcc aagtggcaga tttgttattg gtgggcctca gggtgatgct    900

ggtttgactg gacgcaaaat cattgtggac acttatggcg gttggggtgc tcatggagga    960

ggtgcctttt caggaaagga ttataccaag gtcgaccgtt cagctgctta tgctgctcgt   1020

tgggtggcaa aatcccttgt taaaggaggt ctgtgccgga gggttcttgt tcaggtctct   1080

tatgctattg gagtttctca tccattatct atctccattt tccattatgg tacctctcag   1140

aagagtgaga gagagctatt agagattgtg aagaagaatt tcgatctccg ccctggggtc   1200

attgtcaggg atctggatct gaagaagcca atttatcaga ggactgcagc ctatggccac   1260

tttggtaggg acagcttccc atgggaagtg cccaaaaagc ttaaatattg aaagtgttag   1320

ccttttttcc ccagacttgt tggcgtaggc tacagagaag ccttcaagct ctgagggaaa   1380

gggccctcct tcctaaattt tcctgtcctc tttcagctcc tgaccagttg cagtcactct   1440

agtcaatgac atgaatttta gcttttgtgg gggactgtaa gttgggcttg ctattctgtc   1500

cctaggtgtt ttgttcacca ttataatgaa tttagtgagc ataggtgatc catgtaactg   1560

cctagaaaca acactgtagt aaataatgct ttgaaattga acctttgtgc cctatcaccc   1620

aacgctccaa agtcataatt gcattgactt tccccaccag atgctgaaaa tgtccttgtg   1680

atgtgcacgt aaagtacttg tagttccact tatagcctct gtctggcaat gccacagccc   1740

tgtcagcatg aatttgtaat gtcttgagct ctattatgaa tgtgaagcct tccccttatc   1800

ctccctgtaa cttgatccat ttctaattat gtagctcttt gtcagggagt gttccctatc   1860

caatcaatct tgcatgtaac gcaagttccc agttggagct ccagcctgac atcaaaaaag   1920

gcagttacca ttaaaccatc tccctggtgc ttatgctctt aattgccacc tctaacagca   1980

ccaaatcaaa atctctccac tttcagctgt cttttggagg acgtacgtaa taaggtttta   2040

atttagtaaa ccaatcctat gcatggtttc agcactagcc aaacctcacc aactcctagt   2100

tctagaaaaa caggcacttg gcagccttgt gatgtcatac agagaagtca cagggcagta   2160

cctgagggtc tgtaggttgc acactttggt accagataac tttttttttt ctttataaga   2220

aagcctgagt actccacact gcacaataac tcctcccagg gttttaactt tgttttattt   2280

tcaaaaccag gtccaatgag ctttctgaac agctggtgta gctacagaga aaccagcttc   2340

cttcagagag cagtgctttt ggcggggagg aggaaatccc ttcatacttg aacgttttct   2400

aattgcttat ttattgtatt ctggggtatg gcgtaagtac agagaagcca tcacctcaga   2460

tggcagcttt taaaagattt tttttttttc tctcaacacc atgattcctt taacaacatg   2520

tttccagcat tcccaggtag gccaaggtgt cctacagaaa aaccttgggt tagacctaca   2580

gggggtctgg ctggtgttaa cagaagggag ggcagagctg gtgcggctgg ccatggagaa   2640

agctgacttg gctggtgtgg tacagagaag ccagcttgtt tacatgctta ttccatgact   2700

gcttgcccta agcagaaagt gcctttcagg atctattttt ggaggtttat tacgtatgtc   2760

tggttctcaa ttccaacagt ttaatgaaga tctaaataaa atgctaggtt ctaccttaaa   2820

aaaaaaaaaa aaaaa                                                    2835


<210>  172
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  172

Met Asn Gly Gln Leu Asn Gly Phe His Glu Ala Phe Ile Glu Glu Gly 
1               5                   10                  15      


Thr Phe Leu Phe Thr Ser Glu Ser Val Gly Glu Gly His Pro Asp Lys 
            20                  25                  30          


Ile Cys Asp Gln Ile Ser Asp Ala Val Leu Asp Ala His Leu Gln Gln 
        35                  40                  45              


Asp Pro Asp Ala Lys Val Ala Cys Glu Thr Val Ala Lys Thr Gly Met 
    50                  55                  60                  


Ile Leu Leu Ala Gly Glu Ile Thr Ser Arg Ala Ala Val Asp Tyr Gln 
65                  70                  75                  80  


Lys Val Val Arg Glu Ala Val Lys His Ile Gly Tyr Asp Asp Ser Ser 
                85                  90                  95      


Lys Gly Phe Asp Tyr Lys Thr Cys Asn Val Leu Val Ala Leu Glu Gln 
            100                 105                 110         


Gln Ser Pro Asp Ile Ala Gln Gly Val His Leu Asp Arg Asn Glu Glu 
        115                 120                 125             


Asp Ile Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Thr Asp 
    130                 135                 140                 


Glu Thr Glu Glu Cys Met Pro Leu Thr Ile Val Leu Ala His Lys Leu 
145                 150                 155                 160 


Asn Ala Lys Leu Ala Glu Leu Arg Arg Asn Gly Thr Leu Pro Trp Leu 
                165                 170                 175     


Arg Pro Asp Ser Lys Thr Gln Val Thr Val Gln Tyr Met Gln Asp Arg 
            180                 185                 190         


Gly Ala Val Leu Pro Ile Arg Val His Thr Ile Val Ile Ser Val Gln 
        195                 200                 205             


His Asp Glu Glu Val Cys Leu Asp Glu Met Arg Asp Ala Leu Lys Glu 
    210                 215                 220                 


Lys Val Ile Lys Ala Val Val Pro Ala Lys Tyr Leu Asp Glu Asp Thr 
225                 230                 235                 240 


Ile Tyr His Leu Gln Pro Ser Gly Arg Phe Val Ile Gly Gly Pro Gln 
                245                 250                 255     


Gly Asp Ala Gly Leu Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly 
            260                 265                 270         


Gly Trp Gly Ala His Gly Gly Gly Ala Phe Ser Gly Lys Asp Tyr Thr 
        275                 280                 285             


Lys Val Asp Arg Ser Ala Ala Tyr Ala Ala Arg Trp Val Ala Lys Ser 
    290                 295                 300                 


Leu Val Lys Gly Gly Leu Cys Arg Arg Val Leu Val Gln Val Ser Tyr 
305                 310                 315                 320 


Ala Ile Gly Val Ser His Pro Leu Ser Ile Ser Ile Phe His Tyr Gly 
                325                 330                 335     


Thr Ser Gln Lys Ser Glu Arg Glu Leu Leu Glu Ile Val Lys Lys Asn 
            340                 345                 350         


Phe Asp Leu Arg Pro Gly Val Ile Val Arg Asp Leu Asp Leu Lys Lys 
        355                 360                 365             


Pro Ile Tyr Gln Arg Thr Ala Ala Tyr Gly His Phe Gly Arg Asp Ser 
    370                 375                 380                 


Phe Pro Trp Glu Val Pro Lys Lys Leu Lys Tyr 
385                 390                 395 


<210>  173
<211>  3236
<212>  DNA
<213>  Homosapiens

<400>  173
gtgacccacc tgcctcctcc gcagagcaat ggcggtgtct gccgggtccg cgcggacctc     60

gcccagctca gataaagtac agaaagacaa ggctgaactg atctcagggc ccaggcagga    120

cagccgaata gggaaactct tgggttttga gtggacagat ttgtccagtt ggcggaggct    180

ggtgaccctg ctgaatcgac caacggaccc tgcaagctta gctgtctttc gttttctttt    240

tgggttcttg atggtgctag acattcccca ggagcggggg ctcagctctc tggaccggaa    300

ataccttgat gggctggatg tgtgccgctt ccccttgctg gatgccctac gcccactgcc    360

acttgactgg atgtatcttg tctacaccat catgtttctg ggggcactgg gcatgatgct    420

gggcctgtgc taccggataa gctgtgtgtt attcctgctg ccatactggt atgtgtttct    480

cctggacaag acatcatgga acaaccactc ctatctgtat gggttgttgg cctttcagct    540

aacattcatg gatgcaaacc actactggtc tgtggacggt ctgctgaatg cccataggag    600

gaatgcccac gtgccccttt ggaactatgc agtgctccgt ggccagatct tcattgtgta    660

cttcattgcg ggtgtgaaaa agctggatgc agactgggtt gaaggctatt ccatggaata    720

tttgtcccgg cactggctct tcagtccctt caaactgctg ttgtctgagg agctgactag    780

cctgctggtc gtgcactggg gtgggctgct gcttgacctc tcagctggtt tcctgctctt    840

ttttgatgtc tcaagatcca ttggcctgtt ctttgtgtcc tacttccact gcatgaattc    900

ccagcttttc agcattggta tgttctccta cgtcatgctg gccagcagcc ctctcttctg    960

ctcccctgag tggcctcgga agctggtgtc ctactgcccc cgaaggttgc aacaactgtt   1020

gcccctcaag gcagcccctc agcccagtgt ttcctgtgtg tataagagga gccggggcaa   1080

aagtggccag aagccagggc tgcgccatca gctgggagct gccttcaccc tgctctacct   1140

cctggagcag ctattcctgc cctattctca ttttctcacc cagggctata acaactggac   1200

aaatgggctg tatggctatt cctgggacat gatggtgcac tcccgctccc accagcacgt   1260

gaagatcacc taccgtgatg gccgcactgg cgaactgggc taccttaacc ctggggtatt   1320

tacacagagt cggcgatgga aggatcatgc agacatgctg aagcaatatg ccacttgcct   1380

gagccgcctg cttcccaagt ataatgtcac tgagccccag atctactttg atatttgggt   1440

ctccatcaat gaccgcttcc agcagaggat ttttgaccct cgtgtggaca tcgtgcaggc   1500

cgcttggtca ccctttcagc gcacatcctg ggtgcaacca ctcttgatgg acctgtctcc   1560

ctggagggcc aagttacagg aaatcaagag cagcctagac aaccacactg aggtggtctt   1620

cattgcagat ttccctggac tgcacttgga gaattttgtg agtgaagacc tgggcaacac   1680

tagcatccag ctgctgcagg gggaagtgac tgtggagctt gtggcagaac agaagaacca   1740

gactcttcga gagggagaaa aaatgcagtt gcctgctggt gagtaccata aggtgtatac   1800

gacatcacct agcccttctt gctacatgta cgtctatgtc aacactacag agcttgcact   1860

ggagcaagac ctggcatatc tgcaagaatt aaaggaaaag gtggagaatg gaagtgaaac   1920

agggcctcta cccccagagc tgcagcctct gttggaaggg gaagtaaaag ggggccctga   1980

gccaacacct ctggttcaga cctttcttag acgccaacaa aggctccagg agattgaacg   2040

ccggcgaaat actcctttcc atgagcgatt cttccgcttc ttgttgcgaa agctctatgt   2100

ctttcgccgc agcttcctga tgacttgtat ctcacttcga aatctgatat taggccgtcc   2160

ttccctggag cagctggccc aggaggtgac ttatgcaaac ttgagaccct ttgaggcagt   2220

tggagaactg aatccctcaa acacggattc ttcacattct aatcctcctg agtcaaatcc   2280

tgatcctgtc cactcagagt tctgaagggg gccagatgtt gggtgcagat gtagaagcag   2340

ccagtcacag acccattcta tgcaatggac atttatttga aaaaaattct caaaagtttt   2400

tttttttttt ttgggggggc ggggttctaa agctgttttt aactccgaga ttacaactta   2460

gaggaaccaa ggaaataaag caaataagat ttaacaaccc aagattaaga ggccaggaag   2520

aggttagacg caatgtgaaa ctgtcctcct aggataaggt ttaaagtggc tttttggggg   2580

ctgggtgccg tggctcacgc ctgtaatccc agcattttgg gaggctgagg tgggcagatc   2640

acttgaggcc aggagttcga gaccagcctg gccaacatgg caaaacccct tctctactaa   2700

aaatacaaaa attagccaga cgtggtggtg ggtgcctgta atccaactac ccaggaggct   2760

gaggcatgag aatcgcttgg gcccaggagg tggaggttgc agtgagccga gatcgagcca   2820

ctgcactcct gggcaacaga gcaagacttc gtctcaaaat aaataaataa agtggctctt   2880

ggggaaaagc aatttaatgt accacgatga atagctaact gttcccaagt gtttgctatg   2940

tgcaacacac cgcgtgagca gtgttacctg cattattaca ttaggctgag aggtaaaata   3000

atttgcccga agacatacag ctagtgacga atggactgat ggtttgaact taacgtctat   3060

ttgacttaag gtcctgcacc ctgccacttg taattttcag aatcactgat aatctgaaat   3120

aatgcagctt aaaacatgtt ttcttaatta aaagtataaa aaaaaaaaaa aaaaaaaaaa   3180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       3236


<210>  174
<211>  758
<212>  PRT
<213>  Homosapiens

<400>  174

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
1               5                   10                  15      


Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
            20                  25                  30          


Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
        35                  40                  45              


Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
    50                  55                  60                  


Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
65                  70                  75                  80  


Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                85                  90                  95      


Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
            100                 105                 110         


Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
        115                 120                 125             


Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
    130                 135                 140                 


Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
145                 150                 155                 160 


Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                165                 170                 175     


Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
            180                 185                 190         


Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
        195                 200                 205             


Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
    210                 215                 220                 


Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
225                 230                 235                 240 


Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                245                 250                 255     


Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
            260                 265                 270         


Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
        275                 280                 285             


Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
    290                 295                 300                 


Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
305                 310                 315                 320 


Ser Tyr Cys Pro Arg Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                325                 330                 335     


Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
            340                 345                 350         


Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
        355                 360                 365             


Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
    370                 375                 380                 


Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
385                 390                 395                 400 


Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                405                 410                 415     


Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
            420                 425                 430         


Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
        435                 440                 445             


Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
    450                 455                 460                 


Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
465                 470                 475                 480 


Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                485                 490                 495     


Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
            500                 505                 510         


Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
        515                 520                 525             


Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
    530                 535                 540                 


Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
545                 550                 555                 560 


Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                565                 570                 575     


Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
            580                 585                 590         


Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
        595                 600                 605             


Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
    610                 615                 620                 


Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
625                 630                 635                 640 


Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                645                 650                 655     


Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
            660                 665                 670         


Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
        675                 680                 685             


Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
    690                 695                 700                 


Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
705                 710                 715                 720 


Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                725                 730                 735     


Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
            740                 745                 750         


Pro Val His Ser Glu Phe 
        755             


<210>  175
<211>  702
<212>  DNA
<213>  Homosapiens

<400>  175
aggaagccga ctaggcgaat tcacttactg accggcctgg gctgctctga gacatggagg     60

aagccagtga aggtggagga aatgatcgtg tgcggaacct gcaaagtgag gtggagggag    120

ttaagaatat tatgacccag aatgtggagc ggatcctggc ccggggggaa aacttggaac    180

atctccgcaa caagacagag gatctggaag ccacatctga gcacttcaag acgacatcgc    240

agaaggtggc tcggaaattc tggtggaaga acgtgaagat gattgtcctt atctgcgtga    300

ttgtttttat catcatcctc ttcattgtgc tctttgccac tggtgccttc tcttaagtaa    360

cagggaacct ctcccacctg cccttctttt cagggacaac cctccataaa tgtgtgccaa    420

gagggtctcc tttcctgtct tcctctacag agaatgctgc tcggtcctcc tacccctctt    480

cccgaggccc tgctgccacg ttgtatgccc cagaaggtac cttggtcccc cggaaggaga    540

gaaaaaagag agatggactg tggctgcatt tcttgggtcc ttagagtggg ctggagagac    600

ctagagggcc cagcatgtgg ctgggaaact gttggtggcc agtgggtaat aaagaccttt    660

cagtatccct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                       702


<210>  176
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  176

Met Glu Glu Ala Ser Glu Gly Gly Gly Asn Asp Arg Val Arg Asn Leu 
1               5                   10                  15      


Gln Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln Asn Val Glu 
            20                  25                  30          


Arg Ile Leu Ala Arg Gly Glu Asn Leu Glu His Leu Arg Asn Lys Thr 
        35                  40                  45              


Glu Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr Ser Gln Lys 
    50                  55                  60                  


Val Ala Arg Lys Phe Trp Trp Lys Asn Val Lys Met Ile Val Leu Ile 
65                  70                  75                  80  


Cys Val Ile Val Phe Ile Ile Ile Leu Phe Ile Val Leu Phe Ala Thr 
                85                  90                  95      


Gly Ala Phe Ser 
            100 


<210>  177
<211>  694
<212>  DNA
<213>  Homosapiens

<400>  177
gctcttcctc cggggccgct ggcactgcgg ccgctccgca ggcagagaag ccgggagcgg     60

gcgaggcggc ggcggcagca gcgatggcag gaatagagtt ggagcggtgc cagcagcagg    120

cgaacgaggt gacggaaatt atgcgtaaca acttcggcaa ggtcctggag cgtggtgtga    180

agctggccga actgcagcag cgttcagacc aactcctgga tatgagctca accttcaaca    240

agactacaca gaacctggcc cagaagaagt gctgggagaa catccgttac cggatctgcg    300

tggggctggt ggtggttggt gtcctgctca tcatcctgat tgtgctgctg gtcgtctttc    360

tccctcagag cagtgacagc agtagtgccc cacggaccca ggatgcaggc attgcctcag    420

ggcctgggaa ctgacccagc tggtcctgaa ggagaagcca aatggctgca ctggccgatt    480

ctggtctcca gaggaccttg gtgtttgctc tcccttgacc caccccagtg agtgccaaag    540

ggcagcccca acatgtgcac ccctgcattt cctgtcatgc cacagactgg cccttgaggg    600

cagcctgctg tactggccat gctgggccag ccccacctgg agctcagtaa aaactgctgt    660

ttgataaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                694


<210>  178
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  178

Met Ala Gly Ile Glu Leu Glu Arg Cys Gln Gln Gln Ala Asn Glu Val 
1               5                   10                  15      


Thr Glu Ile Met Arg Asn Asn Phe Gly Lys Val Leu Glu Arg Gly Val 
            20                  25                  30          


Lys Leu Ala Glu Leu Gln Gln Arg Ser Asp Gln Leu Leu Asp Met Ser 
        35                  40                  45              


Ser Thr Phe Asn Lys Thr Thr Gln Asn Leu Ala Gln Lys Lys Cys Trp 
    50                  55                  60                  


Glu Asn Ile Arg Tyr Arg Ile Cys Val Gly Leu Val Val Val Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ile Leu Ile Val Leu Leu Val Val Phe Leu Pro Gln Ser 
                85                  90                  95      


Ser Asp Ser Ser Ser Ala Pro Arg Thr Gln Asp Ala Gly Ile Ala Ser 
            100                 105                 110         


Gly Pro Gly Asn 
        115     


<210>  179
<211>  601
<212>  DNA
<213>  Homosapiens

<400>  179
ccgagggctg tgtcagaagg ctgggcagcc atggcgtcct atttcgatga acacgactgc     60

gagccgtcgg accctgagca ggagacgcga accaacatgc tgctggagct cgcaaggtca    120

cttttcaata ggatggactt tgaagacttg gggttggtag tagattggga ccaccacctg    180

cctccaccag ctgccaagac tgtggttgag aacctcccca ggacagtcat cagaggctct    240

caggctgagc tcaagtgccc cgtgtgtctt ttggaatttg aggaggagga gactgccatt    300

gagatgcctt gccatcacct tttccattcc agctgcattc tgccctggct aagcaagaca    360

aattcctgtc ccttgtgccg ctatgagctg cccactgatg acgacactta tgaggagcac    420

agacgagata aggctcgaaa acagcagcag caacaccgac tggagaacct ccatggagcc    480

atgtacacgt gaggaggttg gggctgagtg ctggccctct gcgtcttcct tattaacctt    540

gaatcctcat taaaggtttc tttaccctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    600

a                                                                    601


<210>  180
<211>  153
<212>  PRT
<213>  Homosapiens

<400>  180

Met Ala Ser Tyr Phe Asp Glu His Asp Cys Glu Pro Ser Asp Pro Glu 
1               5                   10                  15      


Gln Glu Thr Arg Thr Asn Met Leu Leu Glu Leu Ala Arg Ser Leu Phe 
            20                  25                  30          


Asn Arg Met Asp Phe Glu Asp Leu Gly Leu Val Val Asp Trp Asp His 
        35                  40                  45              


His Leu Pro Pro Pro Ala Ala Lys Thr Val Val Glu Asn Leu Pro Arg 
    50                  55                  60                  


Thr Val Ile Arg Gly Ser Gln Ala Glu Leu Lys Cys Pro Val Cys Leu 
65                  70                  75                  80  


Leu Glu Phe Glu Glu Glu Glu Thr Ala Ile Glu Met Pro Cys His His 
                85                  90                  95      


Leu Phe His Ser Ser Cys Ile Leu Pro Trp Leu Ser Lys Thr Asn Ser 
            100                 105                 110         


Cys Pro Leu Cys Arg Tyr Glu Leu Pro Thr Asp Asp Asp Thr Tyr Glu 
        115                 120                 125             


Glu His Arg Arg Asp Lys Ala Arg Lys Gln Gln Gln Gln His Arg Leu 
    130                 135                 140                 


Glu Asn Leu His Gly Ala Met Tyr Thr 
145                 150             


<210>  181
<211>  1527
<212>  DNA
<213>  Homosapiens

<400>  181
ggcgccacga gggggccgag cagggtgcgg cggcggcggg gcgctccggg gaggccagga     60

cagctgatgg ttgtggcaga aacatctcaa ggtagctggt ccgcccccac ttccccatct    120

acctcttgtc ctccccccaa caccaccacc accctggctc ccctccctca tgaccgcctg    180

gatcctcctg cctgtcagcc tgtcagcgtt ctccatcact ggcatatgga ctgtgtatgc    240

catggctgtg atgaaccacc atgtatgccc tgtggagaac tggtcctaca acgagtcctg    300

ccctcctgac cctgctgagc aagggggtcc caagacctgc tgcaccctgg acgatgtccc    360

cctcatcagc aagtgtggct cctatccccc agaaagctgc ctcttcagcc tcattggcaa    420

catgggtgct ttcatggtgg ccctgatctg cctcctgcgc tacgggcagc tcctggagca    480

gagtcggcac tcttgggtta acaccacggc actcatcaca ggctgcacca acgctgcggg    540

cctcttggtg gttggcaact ttcaggtgga tcatgccagg tctctgcact acgttggagc    600

tggcgtggcc ttccctgcgg ggctgctctt tgtttgcctg cactgtgctc tctcctacca    660

aggggccacc gccccgctgg acctggctgt ggcctatctg cgaagtgtgc tggctgtcat    720

cgcctttatc accctggtcc tcagtggagt cttctttgtc catgagagtt ctcagctgca    780

acatggggca gccctgtgtg agtgggtgtg tgtcatcgat atcctcattt tctatggcac    840

cttcagctac gagtttgggg cagtctcctc agacacactg gtggctgcac tgcagcctac    900

ccctggccgg gcctgcaagt cctccgggag cagcagcacc tccacccacc tcaactgtgc    960

ccccgagagc atcgctatga tctaaggtct ggggagggtg gctggcccgg cctccacagc   1020

accccacccc atatcttctt tccatttatt tcgtaccaaa aacaattttg agaaagtatt   1080

ctgttgggat ctgggcttcc tcacttctgg agaagtggcc atcccatgcc cacctgtgcc   1140

atggaggagt gggccctgcc agctgccaca gctgcatgac ctgcttcccc accccacggt   1200

gtcgttttgt ttttaaaggt cacctgtcct cactcaccca gccagccctt caggtgcctt   1260

ctactcccag tgccaaagcc agaccactgg ggtttcctgc tgcaggaatt gggggctggg   1320

aacagcagag gggatagaag tctggtggag gtggagtggg cacgccttag cctacggaaa   1380

ggcccatttc tgggcccact gagctgcact gggattcttc actctgcccc tcacttcctt   1440

tagggcaaat aacacagcag aaccacgtgg gtattttagt actttttttt atattaaaag   1500

aattctaatt tgaaaaaaaa aaaaaaa                                       1527


<210>  182
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  182

Met Thr Ala Trp Ile Leu Leu Pro Val Ser Leu Ser Ala Phe Ser Ile 
1               5                   10                  15      


Thr Gly Ile Trp Thr Val Tyr Ala Met Ala Val Met Asn His His Val 
            20                  25                  30          


Cys Pro Val Glu Asn Trp Ser Tyr Asn Glu Ser Cys Pro Pro Asp Pro 
        35                  40                  45              


Ala Glu Gln Gly Gly Pro Lys Thr Cys Cys Thr Leu Asp Asp Val Pro 
    50                  55                  60                  


Leu Ile Ser Lys Cys Gly Ser Tyr Pro Pro Glu Ser Cys Leu Phe Ser 
65                  70                  75                  80  


Leu Ile Gly Asn Met Gly Ala Phe Met Val Ala Leu Ile Cys Leu Leu 
                85                  90                  95      


Arg Tyr Gly Gln Leu Leu Glu Gln Ser Arg His Ser Trp Val Asn Thr 
            100                 105                 110         


Thr Ala Leu Ile Thr Gly Cys Thr Asn Ala Ala Gly Leu Leu Val Val 
        115                 120                 125             


Gly Asn Phe Gln Val Asp His Ala Arg Ser Leu His Tyr Val Gly Ala 
    130                 135                 140                 


Gly Val Ala Phe Pro Ala Gly Leu Leu Phe Val Cys Leu His Cys Ala 
145                 150                 155                 160 


Leu Ser Tyr Gln Gly Ala Thr Ala Pro Leu Asp Leu Ala Val Ala Tyr 
                165                 170                 175     


Leu Arg Ser Val Leu Ala Val Ile Ala Phe Ile Thr Leu Val Leu Ser 
            180                 185                 190         


Gly Val Phe Phe Val His Glu Ser Ser Gln Leu Gln His Gly Ala Ala 
        195                 200                 205             


Leu Cys Glu Trp Val Cys Val Ile Asp Ile Leu Ile Phe Tyr Gly Thr 
    210                 215                 220                 


Phe Ser Tyr Glu Phe Gly Ala Val Ser Ser Asp Thr Leu Val Ala Ala 
225                 230                 235                 240 


Leu Gln Pro Thr Pro Gly Arg Ala Cys Lys Ser Ser Gly Ser Ser Ser 
                245                 250                 255     


Thr Ser Thr His Leu Asn Cys Ala Pro Glu Ser Ile Ala Met Ile 
            260                 265                 270     


<210>  183
<211>  1486
<212>  DNA
<213>  Homosapiens

<400>  183
aaaaaccttt cagggctgct ccgagggccg cagctagagt cggcgccacg agggggccga     60

gcagggtgcg gcggcggcgg ggcgctccgg ggaggccagg acagctgatg gttgtggcag    120

aaacatctca aggtagctgg tccgccccca cttccccatc tacctcttgt cctcccccca    180

acaccaccac caccctggct cccctccctc atgaccgcct ggatcctcct gcctgtcagc    240

ctgtcagcgt tctccatcac tggcatatgg actgtgtatg ccatggctgt gatgaaccac    300

catgtatgcc ctgtggagaa ctggtcctac aacgagtcct gccctcctga ccctgctgag    360

caagggggtc ccaagacctg ctgcaccctg gacgatgtcc ccctcatcag tggccctgat    420

ctgcctcctg cgctacgggc agctcctgga gcagagtcgg cactcttggg ttaacaccac    480

ggcactcatc acaggctgca ccaacgctgc gggcctcttg gtggttggca actttcaggt    540

ggatcatgcc aggtctctgc actacgttgg agctggcgtg gccttccctg cggggctgct    600

ctttgtttgc ctgcactgtg ctctctccta ccaaggggcc accgccccgc tggacctggc    660

tgtggcctat ctgcgaagtg tgctggctgt catcgccttt atcaccctgg tcctcagtgg    720

agtcttcttt gtccatgaga gttctcagct gcaacatggg gcagccctgt gtgagtgggt    780

gtgtgtcatc gatatcccca ttttctatgg caccttcagc tacgagtttg gggcagtctc    840

ctcagacaca ctggtggctg cactgcagcc tacccctggc cgggcctgca agtcctccgg    900

gagcagcagc acctccaccc acctcaactg tgcccccgag agcatcgcta tgatctaagg    960

tctggggagg gtggctggcc cggcctccac agcaccccac cccatatctt ctttccattt   1020

atttcgtacc aaaaacaatt ttgagaaagt attctgttgg gatctgggct tcctcacttc   1080

tggagaagtg gccatcccat gcccacctgt gccatggagg agtgggccct gccagctgcc   1140

acagctgcat gacctgcttc cccaccccac ggtgtcgttt tgtttttaaa ggtcacctgt   1200

cctcactcac ccagccagcc cttcaggtgc cttctactcc cagtgccaaa gccagaccac   1260

tggggtttcc tgctgcagga attgggggct gggaacagca gaggggatag aagtctggtg   1320

gaggtggagt gggcacgcct tagcctacgg aaaggcccat ttctgggccc actgagctgc   1380

actgggattc ttcactctgc ccctcacttc ctttagggca aataacacag cagaaccacg   1440

tgggtatttt agtacttttt tttatattaa aagaattcta atttgc                  1486


<210>  184
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  184

Met Tyr Ala Leu Trp Arg Thr Gly Pro Thr Thr Ser Pro Ala Leu Leu 
1               5                   10                  15      


Thr Leu Leu Ser Lys Gly Val Pro Arg Pro Ala Ala Pro Trp Thr Met 
            20                  25                  30          


Ser Pro Ser Ser Val Ala Leu Ile Cys Leu Leu Arg Tyr Gly Gln Leu 
        35                  40                  45              


Leu Glu Gln Ser Arg His Ser Trp Val Asn Thr Thr Ala Leu Ile Thr 
    50                  55                  60                  


Gly Cys Thr Asn Ala Ala Gly Leu Leu Val Val Gly Asn Phe Gln Val 
65                  70                  75                  80  


Asp His Ala Arg Ser Leu His Tyr Val Gly Ala Gly Val Ala Phe Pro 
                85                  90                  95      


Ala Gly Leu Leu Phe Val Cys Leu His Cys Ala Leu Ser Tyr Gln Gly 
            100                 105                 110         


Ala Thr Ala Pro Leu Asp Leu Ala Val Ala Tyr Leu Arg Ser Val Leu 
        115                 120                 125             


Ala Val Ile Ala Phe Ile Thr Leu Val Leu Ser Gly Val Phe Phe Val 
    130                 135                 140                 


His Glu Ser Ser Gln Leu Gln His Gly Ala Ala Leu Cys Glu Trp Val 
145                 150                 155                 160 


Cys Val Ile Asp Ile Pro Ile Phe Tyr Gly Thr Phe Ser Tyr Glu Phe 
                165                 170                 175     


Gly Ala Val Ser Ser Asp Thr Leu Val Ala Ala Leu Gln Pro Thr Pro 
            180                 185                 190         


Gly Arg Ala Cys Lys Ser Ser Gly Ser Ser Ser Thr Ser Thr His Leu 
        195                 200                 205             


Asn Cys Ala Pro Glu Ser Ile Ala Met Ile 
    210                 215             


<210>  185
<211>  1909
<212>  DNA
<213>  Homosapiens

<400>  185
gttgttgggg ccgtcgaggc ggcggcgact ctgcgtcccc ggctcctgat ggaggcgggg     60

ccgcatcccc ggccggggca ctgctgcaag cctggggggc ggctggacat gaaccacggc    120

ttcgtgcacc atatccgacg gaaccagatc gctcgggacg actatgacaa gaaggtgaag    180

caggcggcca aggagaaggt gaggaggcgg cacacgcccg cgccgacgcg gccccgcaag    240

ccagacctgc aggtgtacct gccgcgacac cgaggtgagg ccgcccgccc cgcctgcctc    300

cagcccgcgc gctcttcctg caacgcactc cccttctcta tagggaaaaa ccacttctta    360

ctcctaaggt tcagctcatc tcgtctcttt ccggaacctc cacctcagcg ctcccaaatc    420

tccgctgaat gattctcacc aagaactggg acgactcata agcccccagt taagcatcgc    480

tgtcagagta tcggggagcc agcaagaagt ttatctgccg gtttgcccca ccgtgctgta    540

ttttagtaag gtgctccgct acctagcaaa gagaaagtct ggcacagcga tgagcgacca    600

gcacataatt gcggaatgaa cccagtaaat ggcctttccc cagcttctct gctacctaga    660

gatcacactg gttaatatat gacggtcaat ttttgttaag cattattact ttttttaaaa    720

tgtttttatt ttatttttga gactaggtct ctgtcgcccg ggctggagtg cagtggtgcg    780

atctgggctt actgcagcct tagcctcccg agtacctggg accgcaggcg tgtgccacca    840

cgccggttaa ttttggtatt tcttgtagag aaggggtttc cccggctggg cgcggtggct    900

ctcgcctgta gtcccagcac tttgggaggc cgaggcgggc ggatcacgag gtcaggagat    960

cgagaccatc ctggctaaca tggtgaaacc ccgtctctac taaaaataca aaaaattggc   1020

cgggcgtggt ggtgggcgcc tgtggtccca gctactcggg aggctgaggc aggagaatgg   1080

cgtgaacccg ggaggcggag cttgcagtga gccgagatcg cgccactgca ctccagcctg   1140

ggcaacacag caagactcgg tctcaaaaaa aaaaaaaaaa agagagagag agagggggtt   1200

tctccacgtt gtccaggctg gtctcgaact cctgagctca ggtgatctgc ccgcatcggc   1260

ctcccagggt gctgggatta taggtgtgtg ccactacctt tgttaggcat tagtgaaagt   1320

gcttttagat cttacgtata ttaattcatt gagtctttat acaacctcat aagaaagctt   1380

ctgtctgttt cacagtcagg aaacaggcac agagaggtta aacaacttgc ccaagatctc   1440

agctagtaaa tggcagagcc tggatttgaa cccaggcaga gctctatcca cccttctgct   1500

ttccagtact ttttgctaga caaatgtgca ttgtgtacct actgtgtgac aggattgtgc   1560

tggcctcaga gcagggatgc aaaggtaaat aagtccttga ttggcagcac accaaatgct   1620

tacactggtc cgggcgcggt gattcatgcc tgtgatccta gcagtttggg aggccgaggt   1680

gggcggatcc cttgaggcca ggagttcgaa attaacctgg acaacatggt gaaaccccat   1740

ctctactaaa aatacaaaaa ttggccaggc gtgatggcgg gcggctgtgg tcccagctac   1800

ttgggaggct gaggaaggag aattgcttga acctgggagg cagaggttgc ggtgagccga   1860

gatttagcca ctgcactcca gcctgggcaa cagagcaaga ctccgtctc               1909


<210>  186
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  186

Met Glu Ala Gly Pro His Pro Arg Pro Gly His Cys Cys Lys Pro Gly 
1               5                   10                  15      


Gly Arg Leu Asp Met Asn His Gly Phe Val His His Ile Arg Arg Asn 
            20                  25                  30          


Gln Ile Ala Arg Asp Asp Tyr Asp Lys Lys Val Lys Gln Ala Ala Lys 
        35                  40                  45              


Glu Lys Val Arg Arg Arg His Thr Pro Ala Pro Thr Arg Pro Arg Lys 
    50                  55                  60                  


Pro Asp Leu Gln Val Tyr Leu Pro Arg His Arg Gly Glu Ala Ala Arg 
65                  70                  75                  80  


Pro Ala Cys Leu Gln Pro Ala Arg Ser Ser Cys Asn Ala Leu Pro Phe 
                85                  90                  95      


Ser Ile Gly Lys Asn His Phe Leu Leu Leu Arg Phe Ser Ser Ser Arg 
            100                 105                 110         


Leu Phe Pro Glu Pro Pro Pro Gln Arg Ser Gln Ile Ser Ala Glu 
        115                 120                 125         


<210>  187
<211>  2234
<212>  DNA
<213>  Homosapiens

<400>  187
tggcgcctgc gctggacgac tcggccggta gtggagatgt ccggccggtc taagcgggag     60

tctcgcggtt ccactcgcgg gaagcgagag tctgagtcgc ggggcagctc cggtcgcgtc    120

aagcgggagc gagatcggga gcgggagcct gaggcggcga gctcccgggg cagccctgtg    180

cgcgtgaagc gggagttcga gccggcgagc gcgcgcgagg ccccggcttc tgttgtcccg    240

tttgtgcggg tgaagcggga gcgcgaggtc gatgaggact cggagcctga gcgggaggtg    300

cgagcaaaga atggccgagt ggattctgag gaccggagga gccgccactg cccgtacctg    360

gacaccatta acaggagtgt gctggacttt gactttgaga aactgtgttc tatctccctc    420

tcacacatca atgcttatgc ctgtctggtg tgtggcaagt actttcaagg ccggggtttg    480

aagtctcacg cctacattca cagtgtccag tttagccacc atgttttcct caacctccac    540

accctcaagt tttactgcct tccagacaac tatgagatca tcgattcctc attggaggat    600

atcacgtatg tgttgaagcc cactttcaca aagcagcaaa ttgcaaactt ggacaagcaa    660

gccaaattgt cccgggcata tgatggtacc acttacctgc cgggtattgt gggactgaat    720

aacataaagg ccaatgatta tgccaacgct gtccttcagg ctctatctaa tgttcctcct    780

ctccggaact actttctgga agaagacaat tataagaaca tcaaacgtcc tccaggggat    840

atcatgttct tgttggtcca gcgttttgga gagctgatga gaaagctctg gaaccctcga    900

aatttcaagg cacatgtgtc tccccatgag atgcttcagg cagttgtact ttgcagtaag    960

aagacttttc agatcaccaa acaaggagat ggcgttgact ttctgtcttg gtttctgaat   1020

gctctgcact cagctctggg gggcacaaag aagaaaaaga agactattgt gactgatgtt   1080

ttccaggggt ccatgaggat cttcactaaa aagcttcccc atcctgatct gccagcagaa   1140

gaaaaagagc agttgctcca taatgacgag taccaggaga caatggtgga gtccactttt   1200

atgtacctga cgctggacct tcctactgcc cccctctaca aggacgagaa ggagcagctc   1260

atcattcccc aagtgccact cttcaacatc ctggctaagt tcaatggcat cactgagaag   1320

gaatataaga cttacaagga gaactttctg aagcgcttcc agcttaccaa gttgcctcca   1380

tatctaatct tttgtatcaa gagattcact aagaacaact tctttgttga gaagaatcca   1440

actattgtca atttccctat tacaaatgtg gatctgagag aatacttgtc tgaagaagta   1500

caagcagtac acaagaatac cacctatgac ctcattgcca acatcgtgca tgacggcaag   1560

ccctccgagg gctcctaccg gatccacgtg cttcatcatg ggacaggcaa atggtatgaa   1620

ttacaagacc tccaggtgac tgacatcctt ccccagatga tcacactgtc agaggcttac   1680

attcagattt ggaagaggcg agataatgat gaaaccaacc agcagggggc ttgaaggagg   1740

cgtctagggc tttgctccca agggctgtgg ctgatgatgg taaataagaa cacagaagct   1800

gtagctgaac acaggctggc tggtgggctt cctaggccag cccagcttgt atgggttctg   1860

gctacaccag agcaccaaga gcccacttgc ctgggatggc cccacactgt cactcagctg   1920

ttctttgatc atttttttct agattgatgc tcctttctcc catgcattga gctcccatct   1980

agcttcagca gggcagaacc cttctccaga tgtgtgtaac ttatgtcttg agtatctggg   2040

agtagttgaa gaacagataa ttccttccaa acatcaagcc ttgggattct tggagcaagc   2100

agaaagccag taacttcgct ctgttagagg tggaggattt tcctatggtt ccccccattt   2160

cctgatttgt atttttagat ggattaaata gtctcctgtt tttaaaccaa aaaaaaaaaa   2220

aaaaaaaaaa aaaa                                                     2234


<210>  188
<211>  565
<212>  PRT
<213>  Homosapiens

<400>  188

Met Ser Gly Arg Ser Lys Arg Glu Ser Arg Gly Ser Thr Arg Gly Lys 
1               5                   10                  15      


Arg Glu Ser Glu Ser Arg Gly Ser Ser Gly Arg Val Lys Arg Glu Arg 
            20                  25                  30          


Asp Arg Glu Arg Glu Pro Glu Ala Ala Ser Ser Arg Gly Ser Pro Val 
        35                  40                  45              


Arg Val Lys Arg Glu Phe Glu Pro Ala Ser Ala Arg Glu Ala Pro Ala 
    50                  55                  60                  


Ser Val Val Pro Phe Val Arg Val Lys Arg Glu Arg Glu Val Asp Glu 
65                  70                  75                  80  


Asp Ser Glu Pro Glu Arg Glu Val Arg Ala Lys Asn Gly Arg Val Asp 
                85                  90                  95      


Ser Glu Asp Arg Arg Ser Arg His Cys Pro Tyr Leu Asp Thr Ile Asn 
            100                 105                 110         


Arg Ser Val Leu Asp Phe Asp Phe Glu Lys Leu Cys Ser Ile Ser Leu 
        115                 120                 125             


Ser His Ile Asn Ala Tyr Ala Cys Leu Val Cys Gly Lys Tyr Phe Gln 
    130                 135                 140                 


Gly Arg Gly Leu Lys Ser His Ala Tyr Ile His Ser Val Gln Phe Ser 
145                 150                 155                 160 


His His Val Phe Leu Asn Leu His Thr Leu Lys Phe Tyr Cys Leu Pro 
                165                 170                 175     


Asp Asn Tyr Glu Ile Ile Asp Ser Ser Leu Glu Asp Ile Thr Tyr Val 
            180                 185                 190         


Leu Lys Pro Thr Phe Thr Lys Gln Gln Ile Ala Asn Leu Asp Lys Gln 
        195                 200                 205             


Ala Lys Leu Ser Arg Ala Tyr Asp Gly Thr Thr Tyr Leu Pro Gly Ile 
    210                 215                 220                 


Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala Asn Ala Val Leu 
225                 230                 235                 240 


Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr Phe Leu Glu Glu 
                245                 250                 255     


Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp Ile Met Phe Leu 
            260                 265                 270         


Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu Trp Asn Pro Arg 
        275                 280                 285             


Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu Gln Ala Val Val 
    290                 295                 300                 


Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln Gly Asp Gly Val 
305                 310                 315                 320 


Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser Ala Leu Gly Gly 
                325                 330                 335     


Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val Phe Gln Gly Ser 
            340                 345                 350         


Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp Leu Pro Ala Glu 
        355                 360                 365             


Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln Glu Thr Met Val 
    370                 375                 380                 


Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro Thr Ala Pro Leu 
385                 390                 395                 400 


Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln Val Pro Leu Phe 
                405                 410                 415     


Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys Glu Tyr Lys Thr 
            420                 425                 430         


Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr Lys Leu Pro Pro 
        435                 440                 445             


Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn Asn Phe Phe Val 
    450                 455                 460                 


Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr Asn Val Asp Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His Lys Asn Thr Thr 
                485                 490                 495     


Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys Pro Ser Glu Gly 
            500                 505                 510         


Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly Lys Trp Tyr Glu 
        515                 520                 525             


Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln Met Ile Thr Leu 
    530                 535                 540                 


Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp Asn Asp Glu Thr 
545                 550                 555                 560 


Asn Gln Gln Gly Ala 
                565 


<210>  189
<211>  2026
<212>  DNA
<213>  Homosapiens

<400>  189
gccatggctg agtcacacct gctgcagtgg ctgctgctgc tgctgcccac gctctgtggc     60

ccaggcactg ctgcctggac cacctcatcc ttggcctgtg cccagggccc tgagttctgg    120

tgccaaagcc tggagcaagc attgcagtgc agagccctag ggcattgcct acaggaagtc    180

tggggacatg tgggagccga tgacctatgc caagagtgtg aggacatcgt ccacatcctt    240

aacaagatgg ccaaggaggc cattttccag gacacgatga ggaagttcct ggagcaggag    300

tgcaacgtcc tccccttgaa gctgctcatg ccccagtgca accaagtgct tgacgactac    360

ttccccctgg tcatcgacta cttccagaac cagactgact caaacggcat ctgtatgcac    420

ctgggcctgt gcaaatcccg gcagccagag ccagagcagg agccagggat gtcagacccc    480

ctgcccaaac ctctgcggga ccctctgcca gaccctctgc tggacaagct cgtcctccct    540

gtgctgcccg gggccctcca ggcgaggcct gggcctcaca cacaggatct ctccgagcag    600

caattcccca ttcctctccc ctattgctgg ctctgcaggg ctctgatcaa gcggatccaa    660

gccatgattc ccaagggtgc gctagctgtg gcagtggccc aggtgtgccg cgtggtacct    720

ctggtggcgg gcggcatctg ccagtgcctg gctgagcgct actccgtcat cctgctcgac    780

acgctgctgg gccgcatgct gccccagctg gtctgccgcc tcgtcctccg gtgctccatg    840

gatgacagcg ctggcccaag gtcgccgaca ggagaatggc tgccgcgaga ctctgagtgc    900

cacctctgca tgtccgtgac cacccaggcc gggaacagca gcgagcaggc cataccacag    960

gcaatgctcc aggcctgtgt tggctcctgg ctggacaggg aaaagtgcaa gcaatttgtg   1020

gagcagcaca cgccccagct gctgaccctg gtgcccaggg gctgggatgc ccacaccacc   1080

tgccaggccc tcggggtgtg tgggaccatg tccagccctc tccagtgtat ccacagcccc   1140

gacctttgat gagaactcag ctgtccagct gcaaaggaaa agccaagtga gacgggctct   1200

gggaccatgg tgaccaggct cttcccctgc tccctggccc tcgccagctg ccaggctgaa   1260

aagaagcctc agctcccaca ccgccctcct caccgccctt cctcggcagt cacttccact   1320

ggtggaccac gggcccccag ccctgtgtcg gccttgtctg tctcagctca accacagtct   1380

gacaccagag cccacttcca tcctctctgg tgtgaggcac agcgagggca gcatctggag   1440

gagctctgca gcctccacac ctaccacgac ctcccagggc tgggctcagg aaaaaccagc   1500

cactgcttta caggacaggg ggttgaagct gagccccgcc tcacacccac ccccatgcac   1560

tcaaagattg gattttacag ctacttgcaa ttcaaaattc agaagaataa aaaatgggaa   1620

catacagaac tctaaaagat agacatcaga aattgttaag ttaagctttt tcaaaaaatc   1680

agcaattccc cagcgtagtc aagggtggac actgcacgct ctggcatgat gggatggcga   1740

ccgggcaagc tttcttcctc gagatgctct gctgcttgag agctattgct ttgttaagat   1800

ataaaaaggg gtttcttttt gtctttctgt aaggtggact tccagctttt gattgaaagt   1860

cctagggtga ttctatttct gctgtgattt atctgctgaa agctcagctg gggttgtgca   1920

agctagggac ccattcctgt gtaatacaat gtctgcacca atgctaataa agtcctattc   1980

tcttttatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                  2026


<210>  190
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  190

Met Ala Glu Ser His Leu Leu Gln Trp Leu Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Cys Gly Pro Gly Thr Ala Ala Trp Thr Thr Ser Ser Leu Ala Cys 
            20                  25                  30          


Ala Gln Gly Pro Glu Phe Trp Cys Gln Ser Leu Glu Gln Ala Leu Gln 
        35                  40                  45              


Cys Arg Ala Leu Gly His Cys Leu Gln Glu Val Trp Gly His Val Gly 
    50                  55                  60                  


Ala Asp Asp Leu Cys Gln Glu Cys Glu Asp Ile Val His Ile Leu Asn 
65                  70                  75                  80  


Lys Met Ala Lys Glu Ala Ile Phe Gln Asp Thr Met Arg Lys Phe Leu 
                85                  90                  95      


Glu Gln Glu Cys Asn Val Leu Pro Leu Lys Leu Leu Met Pro Gln Cys 
            100                 105                 110         


Asn Gln Val Leu Asp Asp Tyr Phe Pro Leu Val Ile Asp Tyr Phe Gln 
        115                 120                 125             


Asn Gln Thr Asp Ser Asn Gly Ile Cys Met His Leu Gly Leu Cys Lys 
    130                 135                 140                 


Ser Arg Gln Pro Glu Pro Glu Gln Glu Pro Gly Met Ser Asp Pro Leu 
145                 150                 155                 160 


Pro Lys Pro Leu Arg Asp Pro Leu Pro Asp Pro Leu Leu Asp Lys Leu 
                165                 170                 175     


Val Leu Pro Val Leu Pro Gly Ala Leu Gln Ala Arg Pro Gly Pro His 
            180                 185                 190         


Thr Gln Asp Leu Ser Glu Gln Gln Phe Pro Ile Pro Leu Pro Tyr Cys 
        195                 200                 205             


Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Pro Lys 
    210                 215                 220                 


Gly Ala Leu Ala Val Ala Val Ala Gln Val Cys Arg Val Val Pro Leu 
225                 230                 235                 240 


Val Ala Gly Gly Ile Cys Gln Cys Leu Ala Glu Arg Tyr Ser Val Ile 
                245                 250                 255     


Leu Leu Asp Thr Leu Leu Gly Arg Met Leu Pro Gln Leu Val Cys Arg 
            260                 265                 270         


Leu Val Leu Arg Cys Ser Met Asp Asp Ser Ala Gly Pro Arg Ser Pro 
        275                 280                 285             


Thr Gly Glu Trp Leu Pro Arg Asp Ser Glu Cys His Leu Cys Met Ser 
    290                 295                 300                 


Val Thr Thr Gln Ala Gly Asn Ser Ser Glu Gln Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Met Leu Gln Ala Cys Val Gly Ser Trp Leu Asp Arg Glu Lys Cys Lys 
                325                 330                 335     


Gln Phe Val Glu Gln His Thr Pro Gln Leu Leu Thr Leu Val Pro Arg 
            340                 345                 350         


Gly Trp Asp Ala His Thr Thr Cys Gln Ala Leu Gly Val Cys Gly Thr 
        355                 360                 365             


Met Ser Ser Pro Leu Gln Cys Ile His Ser Pro Asp Leu 
    370                 375                 380     


<210>  191
<211>  2724
<212>  DNA
<213>  Homosapiens

<400>  191
ggtgccatgg ctgagtcaca cctgctgcag tggctgctgc tgctgctgcc cacgctctgt     60

ggcccaggca ctgctgcctg gaccacctca tccttggcct gtgcccaggg ccctgagttc    120

tggtgccaaa gcctggagca agcattgcag tgcagagccc tagggcattg cctacaggaa    180

gtctggggac atgtgggagc cgatgaccta tgccaagagt gtgaggacat cgtccacatc    240

cttaacaaga tggccaagga ggccattttc caggacacga tgaggaagtt cctggagcag    300

gagtgcaacg tcctcccctt gaagctgctc atgccccagt gcaaccaagt gcttgacgac    360

tacttccccc tggtcatcga ctacttccag aaccagactg actcaaacgg catctgtatg    420

cacctgggcc tgtgcaaatc ccggcagcca gagccagagc aggagccagg gatgtcagac    480

cccctgccca aacctctgcg ggaccctctg ccagaccctc tgctggacaa gctcgtcctc    540

cctgtgctgc ccggggccct ccaggcgagg cctgggcctc acacacagga tctctccgag    600

cagcaattcc ccattcctct cccctattgc tggctctgca gggctctgat caagcggatc    660

caagccatga ttcccaaggg tgcgctagct gtggcagtgg cccaggtgtg ccgcgtggta    720

cctctggtgg cgggcggcat ctgccagtgc ctggctgagc gctactccgt catcctgctc    780

gacacgctgc tgggccgcat gctgccccag ctggtctgcc gcctcgtcct ccggtgctcc    840

atggatgaca gcgctggccc aaggtcgccg acaggagaat ggctgccgcg agactctgag    900

tgccacctct gcatgtccgt gaccacccag gccgggaaca gcagcgagca ggccatacca    960

caggcaatgc tccaggcctg tgttggctcc tggctggaca gggaaaagtg caagcaattt   1020

gtggagcagc acacgcccca gctgctgacc ctggtgccca ggggctggga tgcccacacc   1080

acctgccagg ccctcggggt gtgtgggacc atgtccagcc ctctccagtg tatccacagc   1140

cccgaccttt gatgagaact cagctgtcca gaaaaagaca ccgtccttta aagtgctgca   1200

gtatggccag acgtggtggc tcacacctgc aatcccagca ccttaggagg ccgaggcagg   1260

aggatccttg aggtcaggag ttcgagacca gcctcgccaa catggtgaaa ccccatttct   1320

actaaaaata caaaaaatta gccaagtgtg gtggcatatg cctgtaatcc caactactca   1380

gaaggccgag gcaggagaat tacttgaacg caggagaatc actgcagccc aggaggcaga   1440

ggttgcagtg agccgagatt gcaccactgc actccagcct gggtgacaga gcaagactcc   1500

atctcagtaa ataaataaat aaataaaaag cgctgcagta gctgtggcct caccctgaag   1560

tcagcgggcc caggcctacc tcactctctc ccttggcaga gaagcagacg tccatagctc   1620

ctctccctca caagcgctcc cagcctgccc tccagctgct gctctcccct cccagtctct   1680

actcactggg atgaggttag gtcatgagga caccaaaaac ctaaaaataa acaaaaagcc   1740

aaacaagcct tagcttttct taaagactga aatgcctgga agtgtccctt tatttataaa   1800

ataacttttg tcatatttct tatacatgtt tcttgtaaga aattcagaaa ctacagacaa   1860

agagagtgga aattacccac tgtcaggcct ctgagcccaa gctaagccat catatcccct   1920

gtgccctgca cgtatacacc cagatggcct gaagcaactg aagatccaca aaagaagtga   1980

aaatagccag ttcctgcctt aactgatgac attccaccat tgtgatttgt tcctgcccca   2040

ccctaactga tcaattgacc ttgtgacaat acaccttccc cacccttgag aaggtgcttt   2100

gtaatattct ccccacccac cccacgcccg cacccccgca cccttaagaa ggtattttgt   2160

aatattctct ccgccattga gaatgtgctt tgtaagatcc accccctgcc cacaaaaaat   2220

tgctcctaac tccaccgcct atcccaaacc tacaagaact aatgataatc ccaccaccct   2280

ttgctgactc tttttggact cagcccacct gcacccaggt gattaaaaag ctttattgtt   2340

cacacaaagc ctgtttggta gtctcttcac agggaagcat gtgacaccca caatcccacc   2400

tagcccagga gagagctacg gcagggtgtg tgttttgaca ctgagcttgg ggctttttcc   2460

atcttctccc cacagcctct ggctccacac ctccaccgtt caagcgccag aaagagctgt   2520

ctatgcagcc tgctcttggg cctggggatg agacacacaa ttcattggct cctggatttt   2580

aagtagacat ttgtaaatct atagctaact actgtcctta aagccattgt ttccattaca   2640

aaatccaact ctctgagaga aaagggtgtt ttaaatttaa aaaaataaaa acaaaaaagt   2700

ttgattgaga aaaaaaaaaa aaaa                                          2724


<210>  192
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  192

Met Ala Glu Ser His Leu Leu Gln Trp Leu Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Cys Gly Pro Gly Thr Ala Ala Trp Thr Thr Ser Ser Leu Ala Cys 
            20                  25                  30          


Ala Gln Gly Pro Glu Phe Trp Cys Gln Ser Leu Glu Gln Ala Leu Gln 
        35                  40                  45              


Cys Arg Ala Leu Gly His Cys Leu Gln Glu Val Trp Gly His Val Gly 
    50                  55                  60                  


Ala Asp Asp Leu Cys Gln Glu Cys Glu Asp Ile Val His Ile Leu Asn 
65                  70                  75                  80  


Lys Met Ala Lys Glu Ala Ile Phe Gln Asp Thr Met Arg Lys Phe Leu 
                85                  90                  95      


Glu Gln Glu Cys Asn Val Leu Pro Leu Lys Leu Leu Met Pro Gln Cys 
            100                 105                 110         


Asn Gln Val Leu Asp Asp Tyr Phe Pro Leu Val Ile Asp Tyr Phe Gln 
        115                 120                 125             


Asn Gln Thr Asp Ser Asn Gly Ile Cys Met His Leu Gly Leu Cys Lys 
    130                 135                 140                 


Ser Arg Gln Pro Glu Pro Glu Gln Glu Pro Gly Met Ser Asp Pro Leu 
145                 150                 155                 160 


Pro Lys Pro Leu Arg Asp Pro Leu Pro Asp Pro Leu Leu Asp Lys Leu 
                165                 170                 175     


Val Leu Pro Val Leu Pro Gly Ala Leu Gln Ala Arg Pro Gly Pro His 
            180                 185                 190         


Thr Gln Asp Leu Ser Glu Gln Gln Phe Pro Ile Pro Leu Pro Tyr Cys 
        195                 200                 205             


Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Pro Lys 
    210                 215                 220                 


Gly Ala Leu Ala Val Ala Val Ala Gln Val Cys Arg Val Val Pro Leu 
225                 230                 235                 240 


Val Ala Gly Gly Ile Cys Gln Cys Leu Ala Glu Arg Tyr Ser Val Ile 
                245                 250                 255     


Leu Leu Asp Thr Leu Leu Gly Arg Met Leu Pro Gln Leu Val Cys Arg 
            260                 265                 270         


Leu Val Leu Arg Cys Ser Met Asp Asp Ser Ala Gly Pro Arg Ser Pro 
        275                 280                 285             


Thr Gly Glu Trp Leu Pro Arg Asp Ser Glu Cys His Leu Cys Met Ser 
    290                 295                 300                 


Val Thr Thr Gln Ala Gly Asn Ser Ser Glu Gln Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Met Leu Gln Ala Cys Val Gly Ser Trp Leu Asp Arg Glu Lys Cys Lys 
                325                 330                 335     


Gln Phe Val Glu Gln His Thr Pro Gln Leu Leu Thr Leu Val Pro Arg 
            340                 345                 350         


Gly Trp Asp Ala His Thr Thr Cys Gln Ala Leu Gly Val Cys Gly Thr 
        355                 360                 365             


Met Ser Ser Pro Leu Gln Cys Ile His Ser Pro Asp Leu 
    370                 375                 380     


<210>  193
<211>  738
<212>  DNA
<213>  Homosapiens

<400>  193
gtatctgtgg taaacccagt gacacggggg agatgacata caaaaagggc aggacctgag     60

aaagattaag ctgcaggctc cctgcccata aaacagggtg tgaaaggcat ctcagcggct    120

gccccaccat ggctacctgg gccctcctgc tccttgcagc catgctcctg ggcaacccag    180

gtctggtctt ctctcgtctg agccctgagt actacgacct ggcaagagcc cacctgcgtg    240

atgaggagaa atcctgcccg tgcctggccc aggagggccc ccagggtgac ctgttgacca    300

aaacacagga gctgggccgt gactacagga cctgtctgac gatagtccaa aaactgaaga    360

agatggtgga taagcccacc cagagaagtg tttccaatgc tgcgacccgg gtgtgtagga    420

cggggaggtc acgatggcgc gacgtctgca gaaatttcat gaggaggtat cagtctagag    480

ttacccaggg cctcgtggcc ggagaaactg cccagcagat ctgtgaggac ctcaggttgt    540

gtataccttc tacaggtccc ctctgagccc tctcaccttg tcctgtggaa gaagcacagg    600

ctcctgtcct cagatcccgg gaacctcagc aacctctgcc ggctcctcgc ttcctcgatc    660

cagaatccac tctccagtct ccctcccctg actccctctg ctgtcctccc ctctcacgag    720

aataaagtgt caagcaag                                                  738


<210>  194
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  194

Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn 
1               5                   10                  15      


Pro Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala 
            20                  25                  30          


Arg Ala His Leu Arg Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln 
        35                  40                  45              


Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg 
    50                  55                  60                  


Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val 
65                  70                  75                  80  


Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys 
                85                  90                  95      


Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg 
            100                 105                 110         


Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala 
        115                 120                 125             


Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro 
    130                 135                 140                 


Leu 
145 


<210>  195
<211>  853
<212>  DNA
<213>  Homosapiens

<400>  195
cctgggccct cctgctcctt gcagccatgc tcctgggcaa cccagcccct gcctccgcat     60

ctgcgtggtg aaggccattg gcctcatcgg tggatctgcg tttcctcggg cccacactgt    120

ctaggattgt gcggggctgg tgagagaaca agatctcttc cgtgttcaag gcagacttcc    180

tgccccctgc accctgctct ctcccgggcc ttgaggtcag tgtgagcccc aagggcaaga    240

acacttctgg aagggagagt ggatttggct gggcctctgg atggaaggtc tggtcttctc    300

tcgtctgagc cctgagtact acgacccggc aagagcccac ctgcgtgatg gggagaaatc    360

ctgcccgtgc gggcaggagg gcccccaggg tgacctgttg accaaaacac aggagctggg    420

ccgtgactac aggacctgtc tgacgatagt ccaaaaactg aagaagatgg tggataagcc    480

cacccagaga agtgtttcca atgctgcgac ccgggtgtgt aggacgggga ggtcacgatg    540

gcgcgacgtc tgcagaaatt tcatgaggag gtatcagtct agagttatcc aaggcctcgt    600

ggccggagaa actgcccagc agatctgtga ggacctcagg ttgtgtatac cttctacagg    660

tcccctctga gccctctcac cttgtcctgt ggaagaagca caggctcctg tcctcagatc    720

ccgggaacgt cagcaacctc tgccggctcc tcgcttcctc gatccagaat ccactctcca    780

gtctccctcc cctgactccc tctgctgtcc tcccctctca ggggaataaa gtgtcaagca    840

agattttagc cgc                                                       853


<210>  196
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  196

Met Glu Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Pro 
1               5                   10                  15      


Ala Arg Ala His Leu Arg Asp Gly Glu Lys Ser Cys Pro Cys Gly Gln 
            20                  25                  30          


Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg 
        35                  40                  45              


Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val 
    50                  55                  60                  


Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys 
65                  70                  75                  80  


Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg 
                85                  90                  95      


Arg Tyr Gln Ser Arg Val Ile Gln Gly Leu Val Ala Gly Glu Thr Ala 
            100                 105                 110         


Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro 
        115                 120                 125             


Leu 
    


<210>  197
<211>  3285
<212>  DNA
<213>  Homosapiens

<400>  197
taggacagcc ttctcaagaa gattctgcca actcaaaaat attattcttt tttttttttt     60

tttttttgct gttgtttctg agaaactagg tgtcttacca ttttaaaatt tcatatttta    120

tttaaaagga aaccagtgaa ttgaaaatga gactaaatat cgctatcttc tttggagctc    180

tctttggtgc tttgggggtg ttactctttt tggtggcttt tggatcggat tattggcttc    240

ttgcaactga agtggggaga tgttcaggtg aaaagaatat agagaacgtc acttttcacc    300

atgaagggtt cttctggagg tgttggttta atgggattgt ggaagagaat gactccaata    360

tttggaagtt ctggtacacc aatcagccac cgtccaagaa ctgcacacat gcttacctgt    420

ctccgtaccc cttcatgaga ggcgagcaca actcgacctc ctatgactct gcagttattt    480

accgtggttt ctgggcagtc ctgatgctcc tgggggtagt tgctgtagtc atcgcaagct    540

ttttgatcat ctgtgcagcc cccttcgcca gccattttct ctacaaagct gggggaggct    600

catatattgc tgcaggcatc ctattttcat tggtggtgat gctgtatgtc atctgggtcc    660

aggcagtggc tgacatggaa agctaccgaa acatgaaaat gaaggactgc ctggatttca    720

ccccttctgt tctgtatggc tggtcatttt tcctggcccc agctgggata tttttttctt    780

tgctagctgg attactattt ctggttgttg gacggcatat tcagatacat cactaaatca    840

actgttgtca caagtatttt cttgagagat tttaaaacaa ggaatacttt ttttccattt    900

tgtttcattg atcccagcat aaagttagta gatataactt tttagttgct attcaaatta    960

atcattttac taaaattttc ttcagtaaga aggtcctaga atctctccag acaccagcaa   1020

gcctctatct tgtctaagtg ctgtcaagga cctagttctt tagggaatag gtaaacaggt   1080

ctccctttca ttgaacatgt tagagttcat gcaggtcgca aaggcctgat aatagcttaa   1140

taccatgaca tggggaaaat ctcgatagat ttggcttaaa gtctccttgg cattcacttc   1200

tgctaattaa aaaaaatcct tgaagaataa ttaagaatgg gcaaggttgt cagagaattt   1260

attttgtttc ttgcccacac agataatatc cacatacaca ttcactggct cttgtgagca   1320

aatgaattta aaaatagaca gcagttgttc taattagtgg gagccatgta ctcaccagtt   1380

aaaatgggcc acaacaaaca agactgagag catgtactta tcttgctttt tcaccaacag   1440

tggtttggtt acctagtttt attcacttaa ttgtgcatgc ttacataaac tttaaactac   1500

atttaaaact agcaaatctg cataccaaat tatgtataac gtagattgaa tttttatgaa   1560

cttaaagtga gttaattgta taatgtaata ttgtttaaaa tatgtaaaaa ccaagcattt   1620

ccgcttggtc cataattcta tttgatattt taaaattctc atttaaaaat tatattgcta   1680

tcattcagca tgtgaaaatt tattgataaa atgtgatttt aatattcttt agatataaac   1740

tttcagcgta cttccatatg aggattataa tagccctgct ttattaaaga ccataaaata   1800

ttaactttcc ccaagatgtt atgggttcca gttcttctga tcatttgatt cctttaatta   1860

ctgtccctca atttcttcat ctttacaata gatatattaa catttacaga tcgactattt   1920

cctttaacct cctagaagaa agtttttgtg gggaaagatg attctgtatt attcagtagc   1980

atagacattt tgcatatcaa agatgttcat ttggcactaa tgttgattga aatcaaatcc   2040

atctgagatg cctagctcgt atttgcattc tggaagcctc catcgcaggg gagctcggca   2100

gggtatgtga gctttgttgg aggtgcggtg tttcattctg cagctgttgt gaggacagag   2160

aggcatggcc cacaggcaaa aaaagtcacc acccagaaga tgctctggga tagaggaact   2220

gctccttttc atcagctctt ccaatgccgt gggagaggtg atcccagtct tctctgtaca   2280

tcttgtgctt ttccattaag acttgttcca gtgggaagga gctttggaaa aattgcaaag   2340

gtctgaatct tcagggcatt ttcatgacag gacttgccaa taataataat aataataata   2400

ataataataa taataataat aaagctccag aggcctaact ggtttctcaa gtcatttcag   2460

tgatatcatt gaaacgtttt tgtggtactt ccctttgtct ttcactgttt catttttata   2520

ttgcttcatt tacttctttg cttttggctt tgttattaga aaaaataatt atgaggtctg   2580

ttgtgcatgt tgactgtgat attaagttat ggcatgccat taagttttcc agacgatgtt   2640

ggatgtatct gattagttca tgtcatctgt aaatacaatt cttttttgta gtactttgga   2700

atggagcctt tttctggtgt actgtatgcc atttaagttt cacatacaag ctgctttcgg   2760

caaaggctcg aatatttata aatttcagat ggttatcctc actttatagt acacttaagt   2820

ggctaccata tattttttat atgacaattg gctgaatagc tgatgtgtat gacactttta   2880

cacagatttg cactttggaa ctattttata gttgtaatgc atcaatcaaa tacatttcaa   2940

gcacatttct tgatcaattt accagcaacc ctctgaagga atgaaggaga gttgtgattg   3000

ctatgtcaat gagtgaaata tacttaaaaa tggcagagat atatagtaca ttattgtagc   3060

aaccttatat ctgatttgag atactgtgtt gccaaatgtc catgttatgt ttatttctct   3120

attggttgta tttattaatt tttagaagcc tttaaactgt gttagaatct ttttgaaaaa   3180

tgttgatttt gcatcataaa gtttcaattt atcaaggata tcttttcagt tacactttta   3240

gaaagagtga ataaaaaggg cagtgagtta tgctcttgga cttgg                   3285


<210>  198
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  198

Met Arg Leu Asn Ile Ala Ile Phe Phe Gly Ala Leu Phe Gly Ala Leu 
1               5                   10                  15      


Gly Val Leu Leu Phe Leu Val Ala Phe Gly Ser Asp Tyr Trp Leu Leu 
            20                  25                  30          


Ala Thr Glu Val Gly Arg Cys Ser Gly Glu Lys Asn Ile Glu Asn Val 
        35                  40                  45              


Thr Phe His His Glu Gly Phe Phe Trp Arg Cys Trp Phe Asn Gly Ile 
    50                  55                  60                  


Val Glu Glu Asn Asp Ser Asn Ile Trp Lys Phe Trp Tyr Thr Asn Gln 
65                  70                  75                  80  


Pro Pro Ser Lys Asn Cys Thr His Ala Tyr Leu Ser Pro Tyr Pro Phe 
                85                  90                  95      


Met Arg Gly Glu His Asn Ser Thr Ser Tyr Asp Ser Ala Val Ile Tyr 
            100                 105                 110         


Arg Gly Phe Trp Ala Val Leu Met Leu Leu Gly Val Val Ala Val Val 
        115                 120                 125             


Ile Ala Ser Phe Leu Ile Ile Cys Ala Ala Pro Phe Ala Ser His Phe 
    130                 135                 140                 


Leu Tyr Lys Ala Gly Gly Gly Ser Tyr Ile Ala Ala Gly Ile Leu Phe 
145                 150                 155                 160 


Ser Leu Val Val Met Leu Tyr Val Ile Trp Val Gln Ala Val Ala Asp 
                165                 170                 175     


Met Glu Ser Tyr Arg Asn Met Lys Met Lys Asp Cys Leu Asp Phe Thr 
            180                 185                 190         


Pro Ser Val Leu Tyr Gly Trp Ser Phe Phe Leu Ala Pro Ala Gly Ile 
        195                 200                 205             


Phe Phe Ser Leu Leu Ala Gly Leu Leu Phe Leu Val Val Gly Arg His 
    210                 215                 220                 


Ile Gln Ile His His 
225                 


<210>  199
<211>  2587
<212>  DNA
<213>  Homosapiens

<400>  199
cccgagcccc gcccctccgg gcccgggtcg gcgcgcccag cctgccagcc gcgctgctgc     60

tgctcctcct gctgtgggac cgctgaccgc gcggctgctc cgctctcccc gctccaagcg    120

ccgatctggg cacccgccac cagcatggac gctcgccgcg tgccgcagaa agatctcaga    180

gtaaagaaga acttaaagaa attcagatat gtgaagttga tttccatgga aacctcgtca    240

tcctctgatg acagttgtga cagctttgct tctgataatt ttgcaaacac gaggctgcag    300

tcagttcggg aaggctgtag gacccgcagc cagtgcaggc actctggacc tctcagggtg    360

gcgatgaagt ttccagcgcg gagtaccagg ggagcaacca acaaaaaagc agagtcccgc    420

cagccctcag agaattctgt gactgattcc aactccgatt cagaagatga aagtggaatg    480

aattttttgg agaaaagggc tttaaatata aagcaaaaca aagcaatgct tgcaaaactc    540

atgtctgaat tagaaagctt ccctggctcg ttccgtggaa gacatcccct cccaggctcc    600

gactcacaat caaggagacc gcgaaggcgt acattcccgg gtgttgcttc caggagaaac    660

cctgaacgga gagctcgtcc tcttaccagg tcaaggtccc ggatcctcgg gtcccttgac    720

gctctaccca tggaggagga ggaggaagag gataagtaca tgttggtgag aaagaggaag    780

accgtggatg gctacatgaa tgaagatgac ctgcccagaa gccgtcgctc cagatcatcc    840

gtgacccttc cgcatataat tcgcccagtg gaagaaatta cagaggagga gttggagaac    900

gtctgcagca attctcgaga gaagatatat aaccgttcac tgggctctac ttgtcatcaa    960

tgccgtcaga agactattga taccaaaaca aactgcagaa acccagactg ctggggcgtt   1020

cgaggccagt tctgtggccc ctgccttcga aaccgttatg gtgaagaggt cagggatgct   1080

ctgctggatc cgaactggca ttgcccgcct tgtcgaggaa tctgcaactg cagtttctgc   1140

cggcagcgag atggacggtg tgcgactggg gtccttgtgt atttagccaa atatcatggc   1200

tttgggaatg tgcatgccta cttgaaaagc ctgaaacagg aatttgaaat gcaagcataa   1260

tatctggaaa atttgctgcc tgccttctac ttctcaaatc tttcttgtaa aagtttccaa   1320

ttttttcact gaaacctgag ttaaaaatct tgatgatcag cctgtttcat aagaaactcc   1380

aatcaagtta atcttagcag acatgtgttt ctggagcatc acagaaggta tattgctagt   1440

tacactttgc cctcctgcag tttcttctct gctcccaacc cccatctcat agcatccccc   1500

tctatttcca atgctcctct ccaaccgctt agtttctgaa tttcttttaa attacagttt   1560

tatgaaagca tattttattt acttggtgtt gaaatagccc tcataaaacc taagcacttg   1620

gaaacacaat aatagtatta actaactaga tctattgaat ttcagagaag agccttctaa   1680

cttgtttaca caaaaacgag tatgatttag cattcatact agttgaaatt tttaatagaa   1740

tcaaggcaca aaagtcttaa aaccatgtgg aaaaattagg taattattgc agattgatgt   1800

ctctcaatcc catgtattgc gcttatgtta caagttgttg tcacagttga gacttaattt   1860

ctcctaattt cttctgcccg aagggtaagt ggtgcgtcca gcttacacaa tcataattca   1920

aaggttggtg ggcaatgtaa tacttaatta aaataatgat ggaagagcta tctggagatt   1980

atgagtaagc tgatttgaat tttcagtata aaactttagt ataattgtag tttgcaaagt   2040

ttatttcagt tcacatgtaa ggtattgcaa ataaattctt ggacaatttt gtatggaaac   2100

ttgatattaa aaactagtct gtggttcttt gcagtttctt gtaaatttat aaaccaggca   2160

caaggttcaa gtttagattt taagcacttt tataacaatg ataagtgcct ttttggagat   2220

gtaactttta gcagtttgtt aacctgacat ctctgccagt ctagtttctg ggcaggtttc   2280

ctgtgtcagt attccccctc ctctttgcat taatcaaggt atttggtaga ggtggaatct   2340

aagtgtttgt atgtccaatt tacttgcata tgtaaaccat tgctgtgcca ttcaatgttt   2400

gatgcataat tggaccttga atcgataagt gtaaatacag cttttgatct gtaatgcttt   2460

tatacaaaag tttattttaa taataaaatg tttgttctaa cttgtctgct tttttaaaaa   2520

taatcttact gtacttaatt ctaatttttt cctcatattt aaataaaagg ccatttccac   2580

cttttct                                                             2587


<210>  200
<211>  371
<212>  PRT
<213>  Homosapiens

<400>  200

Met Asp Ala Arg Arg Val Pro Gln Lys Asp Leu Arg Val Lys Lys Asn 
1               5                   10                  15      


Leu Lys Lys Phe Arg Tyr Val Lys Leu Ile Ser Met Glu Thr Ser Ser 
            20                  25                  30          


Ser Ser Asp Asp Ser Cys Asp Ser Phe Ala Ser Asp Asn Phe Ala Asn 
        35                  40                  45              


Thr Arg Leu Gln Ser Val Arg Glu Gly Cys Arg Thr Arg Ser Gln Cys 
    50                  55                  60                  


Arg His Ser Gly Pro Leu Arg Val Ala Met Lys Phe Pro Ala Arg Ser 
65                  70                  75                  80  


Thr Arg Gly Ala Thr Asn Lys Lys Ala Glu Ser Arg Gln Pro Ser Glu 
                85                  90                  95      


Asn Ser Val Thr Asp Ser Asn Ser Asp Ser Glu Asp Glu Ser Gly Met 
            100                 105                 110         


Asn Phe Leu Glu Lys Arg Ala Leu Asn Ile Lys Gln Asn Lys Ala Met 
        115                 120                 125             


Leu Ala Lys Leu Met Ser Glu Leu Glu Ser Phe Pro Gly Ser Phe Arg 
    130                 135                 140                 


Gly Arg His Pro Leu Pro Gly Ser Asp Ser Gln Ser Arg Arg Pro Arg 
145                 150                 155                 160 


Arg Arg Thr Phe Pro Gly Val Ala Ser Arg Arg Asn Pro Glu Arg Arg 
                165                 170                 175     


Ala Arg Pro Leu Thr Arg Ser Arg Ser Arg Ile Leu Gly Ser Leu Asp 
            180                 185                 190         


Ala Leu Pro Met Glu Glu Glu Glu Glu Glu Asp Lys Tyr Met Leu Val 
        195                 200                 205             


Arg Lys Arg Lys Thr Val Asp Gly Tyr Met Asn Glu Asp Asp Leu Pro 
    210                 215                 220                 


Arg Ser Arg Arg Ser Arg Ser Ser Val Thr Leu Pro His Ile Ile Arg 
225                 230                 235                 240 


Pro Val Glu Glu Ile Thr Glu Glu Glu Leu Glu Asn Val Cys Ser Asn 
                245                 250                 255     


Ser Arg Glu Lys Ile Tyr Asn Arg Ser Leu Gly Ser Thr Cys His Gln 
            260                 265                 270         


Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Asn Cys Arg Asn Pro Asp 
        275                 280                 285             


Cys Trp Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn Arg 
    290                 295                 300                 


Tyr Gly Glu Glu Val Arg Asp Ala Leu Leu Asp Pro Asn Trp His Cys 
305                 310                 315                 320 


Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Phe Cys Arg Gln Arg Asp 
                325                 330                 335     


Gly Arg Cys Ala Thr Gly Val Leu Val Tyr Leu Ala Lys Tyr His Gly 
            340                 345                 350         


Phe Gly Asn Val His Ala Tyr Leu Lys Ser Leu Lys Gln Glu Phe Glu 
        355                 360                 365             


Met Gln Ala 
    370     


<210>  201
<211>  2824
<212>  DNA
<213>  Homosapiens

<400>  201
cccgagcccc gcccctccgg gcccgggtcg gcgcgcccag cctgccagcc gcgctgctgc     60

tgctcctcct gctgtgggac cgctgaccgc gcggctgctc cgctctcccc gctccaagcg    120

ccgatctggg cacccgccac cagcatggac gctcgccgcg tgccgcagaa agatctcaga    180

gtaaagaaga acttaaagaa attcagatat gtgaagttga tttccatgga aacctcgtca    240

tcctctgatg acagttgtga cagctttgct tctgataatt ttgcaaacac gaaacctaaa    300

ttcaggtcag atatcagtga agaactggca agtgtttttt atgaggactc tgataatgaa    360

tctttctgcg gcttttcaga aagtgaggtg caagatgtat tagaccattg tggattttta    420

cagaaaccaa ggccagatgt cactaacgaa ctggccggta tttttcatgc cgactctgac    480

gatgaatcat tttgcggttt ctcagagagt gagatacaag atggaatgag gctgcagtca    540

gttcgggaag gctgtaggac ccgcagccag tgcaggcact ctggacctct cagggtggcg    600

atgaagtttc cagcgcggag taccagggga gcaaccaaca aaaaagcaga gtcccgccag    660

ccctcagaga attctgtgac tgattccaac tccgattcag aagatgaaag tggaatgaat    720

tttttggaga aaagggcttt aaatataaag caaaacaaag caatgcttgc aaaactcatg    780

tctgaattag aaagcttccc tggctcgttc cgtggaagac atcccctccc aggctccgac    840

tcacaatcaa ggagaccgcg aaggcgtaca ttcccgggtg ttgcttccag gagaaaccct    900

gaacggagag ctcgtcctct taccaggtca aggtcccgga tcctcgggtc ccttgacgct    960

ctacccatgg aggaggagga ggaagaggat aagtacatgt tggtgagaaa gaggaagacc   1020

gtggatggct acatgaatga agatgacctg cccagaagcc gtcgctccag atcatccgtg   1080

acccttccgc atataattcg cccagtggaa gaaattacag aggaggagtt ggagaacgtc   1140

tgcagcaatt ctcgagagaa gatatataac cgttcactgg gctctacttg tcatcaatgc   1200

cgtcagaaga ctattgatac caaaacaaac tgcagaaacc cagactgctg gggcgttcga   1260

ggccagttct gtggcccctg ccttcgaaac cgttatggtg aagaggtcag ggatgctctg   1320

ctggatccga actggcattg cccgccttgt cgaggaatct gcaactgcag tttctgccgg   1380

cagcgagatg gacggtgtgc gactggggtc cttgtgtatt tagccaaata tcatggcttt   1440

gggaatgtgc atgcctactt gaaaagcctg aaacaggaat ttgaaatgca agcataatat   1500

ctggaaaatt tgctgcctgc cttctacttc tcaaatcttt cttgtaaaag tttccaattt   1560

tttcactgaa acctgagtta aaaatcttga tgatcagcct gtttcataag aaactccaat   1620

caagttaatc ttagcagaca tgtgtttctg gagcatcaca gaaggtatat tgctagttac   1680

actttgccct cctgcagttt cttctctgct cccaaccccc atctcatagc atccccctct   1740

atttccaatg ctcctctcca accgcttagt ttctgaattt cttttaaatt acagttttat   1800

gaaagcatat tttatttact tggtgttgaa atagccctca taaaacctaa gcacttggaa   1860

acacaataat agtattaact aactagatct attgaatttc agagaagagc cttctaactt   1920

gtttacacaa aaacgagtat gatttagcat tcatactagt tgaaattttt aatagaatca   1980

aggcacaaaa gtcttaaaac catgtggaaa aattaggtaa ttattgcaga ttgatgtctc   2040

tcaatcccat gtattgcgct tatgttacaa gttgttgtca cagttgagac ttaatttctc   2100

ctaatttctt ctgcccgaag ggtaagtggt gcgtccagct tacacaatca taattcaaag   2160

gttggtgggc aatgtaatac ttaattaaaa taatgatgga agagctatct ggagattatg   2220

agtaagctga tttgaatttt cagtataaaa ctttagtata attgtagttt gcaaagttta   2280

tttcagttca catgtaaggt attgcaaata aattcttgga caattttgta tggaaacttg   2340

atattaaaaa ctagtctgtg gttctttgca gtttcttgta aatttataaa ccaggcacaa   2400

ggttcaagtt tagattttaa gcacttttat aacaatgata agtgcctttt tggagatgta   2460

acttttagca gtttgttaac ctgacatctc tgccagtcta gtttctgggc aggtttcctg   2520

tgtcagtatt ccccctcctc tttgcattaa tcaaggtatt tggtagaggt ggaatctaag   2580

tgtttgtatg tccaatttac ttgcatatgt aaaccattgc tgtgccattc aatgtttgat   2640

gcataattgg accttgaatc gataagtgta aatacagctt ttgatctgta atgcttttat   2700

acaaaagttt attttaataa taaaatgttt gttctaactt gtctgctttt ttaaaaataa   2760

tcttactgta cttaattcta attttttcct catatttaaa taaaaggcca tttccacctt   2820

ttct                                                                2824


<210>  202
<211>  450
<212>  PRT
<213>  Homosapiens

<400>  202

Met Asp Ala Arg Arg Val Pro Gln Lys Asp Leu Arg Val Lys Lys Asn 
1               5                   10                  15      


Leu Lys Lys Phe Arg Tyr Val Lys Leu Ile Ser Met Glu Thr Ser Ser 
            20                  25                  30          


Ser Ser Asp Asp Ser Cys Asp Ser Phe Ala Ser Asp Asn Phe Ala Asn 
        35                  40                  45              


Thr Lys Pro Lys Phe Arg Ser Asp Ile Ser Glu Glu Leu Ala Ser Val 
    50                  55                  60                  


Phe Tyr Glu Asp Ser Asp Asn Glu Ser Phe Cys Gly Phe Ser Glu Ser 
65                  70                  75                  80  


Glu Val Gln Asp Val Leu Asp His Cys Gly Phe Leu Gln Lys Pro Arg 
                85                  90                  95      


Pro Asp Val Thr Asn Glu Leu Ala Gly Ile Phe His Ala Asp Ser Asp 
            100                 105                 110         


Asp Glu Ser Phe Cys Gly Phe Ser Glu Ser Glu Ile Gln Asp Gly Met 
        115                 120                 125             


Arg Leu Gln Ser Val Arg Glu Gly Cys Arg Thr Arg Ser Gln Cys Arg 
    130                 135                 140                 


His Ser Gly Pro Leu Arg Val Ala Met Lys Phe Pro Ala Arg Ser Thr 
145                 150                 155                 160 


Arg Gly Ala Thr Asn Lys Lys Ala Glu Ser Arg Gln Pro Ser Glu Asn 
                165                 170                 175     


Ser Val Thr Asp Ser Asn Ser Asp Ser Glu Asp Glu Ser Gly Met Asn 
            180                 185                 190         


Phe Leu Glu Lys Arg Ala Leu Asn Ile Lys Gln Asn Lys Ala Met Leu 
        195                 200                 205             


Ala Lys Leu Met Ser Glu Leu Glu Ser Phe Pro Gly Ser Phe Arg Gly 
    210                 215                 220                 


Arg His Pro Leu Pro Gly Ser Asp Ser Gln Ser Arg Arg Pro Arg Arg 
225                 230                 235                 240 


Arg Thr Phe Pro Gly Val Ala Ser Arg Arg Asn Pro Glu Arg Arg Ala 
                245                 250                 255     


Arg Pro Leu Thr Arg Ser Arg Ser Arg Ile Leu Gly Ser Leu Asp Ala 
            260                 265                 270         


Leu Pro Met Glu Glu Glu Glu Glu Glu Asp Lys Tyr Met Leu Val Arg 
        275                 280                 285             


Lys Arg Lys Thr Val Asp Gly Tyr Met Asn Glu Asp Asp Leu Pro Arg 
    290                 295                 300                 


Ser Arg Arg Ser Arg Ser Ser Val Thr Leu Pro His Ile Ile Arg Pro 
305                 310                 315                 320 


Val Glu Glu Ile Thr Glu Glu Glu Leu Glu Asn Val Cys Ser Asn Ser 
                325                 330                 335     


Arg Glu Lys Ile Tyr Asn Arg Ser Leu Gly Ser Thr Cys His Gln Cys 
            340                 345                 350         


Arg Gln Lys Thr Ile Asp Thr Lys Thr Asn Cys Arg Asn Pro Asp Cys 
        355                 360                 365             


Trp Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn Arg Tyr 
    370                 375                 380                 


Gly Glu Glu Val Arg Asp Ala Leu Leu Asp Pro Asn Trp His Cys Pro 
385                 390                 395                 400 


Pro Cys Arg Gly Ile Cys Asn Cys Ser Phe Cys Arg Gln Arg Asp Gly 
                405                 410                 415     


Arg Cys Ala Thr Gly Val Leu Val Tyr Leu Ala Lys Tyr His Gly Phe 
            420                 425                 430         


Gly Asn Val His Ala Tyr Leu Lys Ser Leu Lys Gln Glu Phe Glu Met 
        435                 440                 445             


Gln Ala 
    450 


<210>  203
<211>  1011
<212>  DNA
<213>  Homosapiens

<400>  203
atgtccaaag ttgtctctca ctgtttttat ttaaaggaac tagacacaaa cctggctgct     60

ttaaccacgg cctctgggag ggctacagct gagaaaatcc gctgtcagga agaagtgaat    120

agaactaaca agactattga gcgcgccaac agattagtga aaggtctgga gaaggaaaat    180

gatttgaaaa tcgagttgaa aattcagcta ggagatgagt tcttcatctg cctttcctct    240

gtgcaaggca cccaaagtga gagcagcagg gcgcagcagt gcccagagct gactgatggc    300

atcaggaaat ctagctcatc ccaaccacag gcagttttta aaattggggt tgtggctccc    360

cctgctaaag cgacattacc cacggacctt gttaccaacc ttggcgacca gagaacgctg    420

atctccaaag gtctagaccc ggtgaaacag cgttcggtgg ccactgaccg gtttccagag    480

tcagagctcc ccctgctgga atccaaagca cgtcgccagg tgagggcttc ccaatgtctt    540

ggaaagcacc aagttggtga gtggcataac ctgatcatgt cattcccact gatcaacaaa    600

gacacactag tggaatttgt cttcctgttt cttgtagccc tcccatcatc aattgggaac    660

ccagagccca ctctgaattt catggaggag aaagatgtac ctaaggtttg ctccacatca    720

cggcgtgtct tctttcgcat gctctcggtg gtcgtgttaa agcaactaga ggaaagggaa    780

ggggagaaag aacgtagagc ctcaaatgcc ctaagtttgg atcaagagca ccttgttaga    840

attaggaatg ctggatttgg tgtgaacttg gtgctgagtt acatcatcag ccataagctt    900

ccagccactg gaaatcttcc tatagacaac agtcctcact tcccagatgc agagcaagcc    960

agagaacctg taggagaaaa ccaggaatat agagccagaa acatacaatg a            1011


<210>  204
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  204

Met Ser Lys Val Val Ser His Cys Phe Tyr Leu Lys Glu Leu Asp Thr 
1               5                   10                  15      


Asn Leu Ala Ala Leu Thr Thr Ala Ser Gly Arg Ala Thr Ala Glu Lys 
            20                  25                  30          


Ile Arg Cys Gln Glu Glu Val Asn Arg Thr Asn Lys Thr Ile Glu Arg 
        35                  40                  45              


Ala Asn Arg Leu Val Lys Gly Leu Glu Lys Glu Asn Asp Leu Lys Ile 
    50                  55                  60                  


Glu Leu Lys Ile Gln Leu Gly Asp Glu Phe Phe Ile Cys Leu Ser Ser 
65                  70                  75                  80  


Val Gln Gly Thr Gln Ser Glu Ser Ser Arg Ala Gln Gln Cys Pro Glu 
                85                  90                  95      


Leu Thr Asp Gly Ile Arg Lys Ser Ser Ser Ser Gln Pro Gln Ala Val 
            100                 105                 110         


Phe Lys Ile Gly Val Val Ala Pro Pro Ala Lys Ala Thr Leu Pro Thr 
        115                 120                 125             


Asp Leu Val Thr Asn Leu Gly Asp Gln Arg Thr Leu Ile Ser Lys Gly 
    130                 135                 140                 


Leu Asp Pro Val Lys Gln Arg Ser Val Ala Thr Asp Arg Phe Pro Glu 
145                 150                 155                 160 


Ser Glu Leu Pro Leu Leu Glu Ser Lys Ala Arg Arg Gln Val Arg Ala 
                165                 170                 175     


Ser Gln Cys Leu Gly Lys His Gln Val Gly Glu Trp His Asn Leu Ile 
            180                 185                 190         


Met Ser Phe Pro Leu Ile Asn Lys Asp Thr Leu Val Glu Phe Val Phe 
        195                 200                 205             


Leu Phe Leu Val Ala Leu Pro Ser Ser Ile Gly Asn Pro Glu Pro Thr 
    210                 215                 220                 


Leu Asn Phe Met Glu Glu Lys Asp Val Pro Lys Val Cys Ser Thr Ser 
225                 230                 235                 240 


Arg Arg Val Phe Phe Arg Met Leu Ser Val Val Val Leu Lys Gln Leu 
                245                 250                 255     


Glu Glu Arg Glu Gly Glu Lys Glu Arg Arg Ala Ser Asn Ala Leu Ser 
            260                 265                 270         


Leu Asp Gln Glu His Leu Val Arg Ile Arg Asn Ala Gly Phe Gly Val 
        275                 280                 285             


Asn Leu Val Leu Ser Tyr Ile Ile Ser His Lys Leu Pro Ala Thr Gly 
    290                 295                 300                 


Asn Leu Pro Ile Asp Asn Ser Pro His Phe Pro Asp Ala Glu Gln Ala 
305                 310                 315                 320 


Arg Glu Pro Val Gly Glu Asn Gln Glu Tyr Arg Ala Arg Asn Ile Gln 
                325                 330                 335     


<210>  205
<211>  2051
<212>  DNA
<213>  Homosapiens

<400>  205
atggcaattc catcactcgt gaagtacaca gataattcaa tcctcatctt caacatgttt     60

tactcttcag ctcaatggaa caattcggat tcctcaacta ttcctgtaaa cctgagtgag    120

caggtatgct cagatgggaa atttgagata aatttgtgta atgttttagg aatttctccc    180

ctgctctccc taccacggta cccatcaggt tcttcctatg caacaattat atgcactggc    240

tttcgaaaag agcccccagg atgggccctc tggtggaggg gagggggacc caccttcacg    300

gatgcagtta gacatgctag tgcttgtggc ccagttgaga catctgggac ctcattaaga    360

acgaggctta aggaagatgc caaagggctt ttaaaagata tctctgaaac cacaaaaaac    420

cttctgctct atatccgcac cagtacgtgg ccactgccac aggcccgctt cccgtgcgct    480

ctccctcacc ccagctgctc tggatgccac aggaagcctc cattcctgcc ccacgatcca    540

gaacctcacc cctggattaa agtagatgaa atgacctggg gcaagtcctc tggcctcaga    600

tcatccactg ccaaatggag atgctgtgtg aagttaaaga agaaaatgac tgaggccctg    660

ggcttagcat atgggaacct cacaggaagg gggcctggaa ccaatacctt aaaacaatac    720

caagtgagga accagacaca caagcctagg ttagaaaaac aaatgttcgt atttagagtt    780

gacagtggtt tagatggtaa ttcaaaggaa aaaaagctcc ccacaacacc cctagtgata    840

ttgggcccgc aggaaggcca agaggaggtg actggagatg aatacgatgt ggagagcatt    900

gatggtcagc ctgatgcctt cacctactat ttggatgcag gccttgccag aaccaccact    960

gacagtaaag tttttggggc catggaagct gtggatggag gcttgtctat cccacaaaaa   1020

tttgctgaga gcctgacaga ctcttctgag ttgaacagca gtaaagagat gaaaattgac   1080

atcatcttca actctcagga atgcaccctg actttggtgg acacaggcat tgccatgacc   1140

aaggatgacc tcataaataa ttttggaacc attgccaagt ctccaagatt gagcaaacaa   1200

gaagaaaaag aacaacatca agctgtccat cgtgtgttca tcatggacag ctgtgatgag   1260

ttgacacaag agtttctcaa ttttattcat ggtttggttg actctcagta tctgcccctc   1320

aacatctctc gagaaatgct taagcagagc aaaatcttaa aagtcattca aacaaacatt   1380

gttaagaagt gccttgagct gttctctgag ctggcagaag acaagaagaa ctacaagaaa   1440

ttccatgagg cagtctatgc tgccgtcggg agctctgtat taccagccat ggtcaacccc   1500

accgtgttct tccacatctc tgtcgacggt gagtccttgg gccgcatctc ttttgagctg   1560

tttgcagaca agtttccaaa gacagcagaa aacttttgtg ctctgaatac tggagagaaa   1620

ggatttggtt acaagggttg ctgctttcac agaattattc cagggtttat gtgtcatggt   1680

ggtgacttca cacaccataa tggcactggt ggcaagtcaa tctacgggga gaaagttgat   1740

gatgacaact tcatcctgaa gcatacaggt cctggcatat tgtccatggc aaatgctgga   1800

cccaacacaa atggttccca gttttgtgga ggccatggag cactttgggt ccaggaatgg   1860

caagaccagc aagaaggtca ccattcctga ctttggacaa ctcgaataag tttgacttgt   1920

gttttatctt aaccactgga ccattccttc tgcagctcag gagagcagcc ctccacccca   1980

tctgctcgca gtattctaga atctttgtgc tctcgctgca gttccctttg ggttccatgt   2040

tttccttgtt c                                                        2051


<210>  206
<211>  629
<212>  PRT
<213>  Homosapiens

<400>  206

Met Ala Ile Pro Ser Leu Val Lys Tyr Thr Asp Asn Ser Ile Leu Ile 
1               5                   10                  15      


Phe Asn Met Phe Tyr Ser Ser Ala Gln Trp Asn Asn Ser Asp Ser Ser 
            20                  25                  30          


Thr Ile Pro Val Asn Leu Ser Glu Gln Val Cys Ser Asp Gly Lys Phe 
        35                  40                  45              


Glu Ile Asn Leu Cys Asn Val Leu Gly Ile Ser Pro Leu Leu Ser Leu 
    50                  55                  60                  


Pro Arg Tyr Pro Ser Gly Ser Ser Tyr Ala Thr Ile Ile Cys Thr Gly 
65                  70                  75                  80  


Phe Arg Lys Glu Pro Pro Gly Trp Ala Leu Trp Trp Arg Gly Gly Gly 
                85                  90                  95      


Pro Thr Phe Thr Asp Ala Val Arg His Ala Ser Ala Cys Gly Pro Val 
            100                 105                 110         


Glu Thr Ser Gly Thr Ser Leu Arg Thr Arg Leu Lys Glu Asp Ala Lys 
        115                 120                 125             


Gly Leu Leu Lys Asp Ile Ser Glu Thr Thr Lys Asn Leu Leu Leu Tyr 
    130                 135                 140                 


Ile Arg Thr Ser Thr Trp Pro Leu Pro Gln Ala Arg Phe Pro Cys Ala 
145                 150                 155                 160 


Leu Pro His Pro Ser Cys Ser Gly Cys His Arg Lys Pro Pro Phe Leu 
                165                 170                 175     


Pro His Asp Pro Glu Pro His Pro Trp Ile Lys Val Asp Glu Met Thr 
            180                 185                 190         


Trp Gly Lys Ser Ser Gly Leu Arg Ser Ser Thr Ala Lys Trp Arg Cys 
        195                 200                 205             


Cys Val Lys Leu Lys Lys Lys Met Thr Glu Ala Leu Gly Leu Ala Tyr 
    210                 215                 220                 


Gly Asn Leu Thr Gly Arg Gly Pro Gly Thr Asn Thr Leu Lys Gln Tyr 
225                 230                 235                 240 


Gln Val Arg Asn Gln Thr His Lys Pro Arg Leu Glu Lys Gln Met Phe 
                245                 250                 255     


Val Phe Arg Val Asp Ser Gly Leu Asp Gly Asn Ser Lys Glu Lys Lys 
            260                 265                 270         


Leu Pro Thr Thr Pro Leu Val Ile Leu Gly Pro Gln Glu Gly Gln Glu 
        275                 280                 285             


Glu Val Thr Gly Asp Glu Tyr Asp Val Glu Ser Ile Asp Gly Gln Pro 
    290                 295                 300                 


Asp Ala Phe Thr Tyr Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr 
305                 310                 315                 320 


Asp Ser Lys Val Phe Gly Ala Met Glu Ala Val Asp Gly Gly Leu Ser 
                325                 330                 335     


Ile Pro Gln Lys Phe Ala Glu Ser Leu Thr Asp Ser Ser Glu Leu Asn 
            340                 345                 350         


Ser Ser Lys Glu Met Lys Ile Asp Ile Ile Phe Asn Ser Gln Glu Cys 
        355                 360                 365             


Thr Leu Thr Leu Val Asp Thr Gly Ile Ala Met Thr Lys Asp Asp Leu 
    370                 375                 380                 


Ile Asn Asn Phe Gly Thr Ile Ala Lys Ser Pro Arg Leu Ser Lys Gln 
385                 390                 395                 400 


Glu Glu Lys Glu Gln His Gln Ala Val His Arg Val Phe Ile Met Asp 
                405                 410                 415     


Ser Cys Asp Glu Leu Thr Gln Glu Phe Leu Asn Phe Ile His Gly Leu 
            420                 425                 430         


Val Asp Ser Gln Tyr Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Lys 
        435                 440                 445             


Gln Ser Lys Ile Leu Lys Val Ile Gln Thr Asn Ile Val Lys Lys Cys 
    450                 455                 460                 


Leu Glu Leu Phe Ser Glu Leu Ala Glu Asp Lys Lys Asn Tyr Lys Lys 
465                 470                 475                 480 


Phe His Glu Ala Val Tyr Ala Ala Val Gly Ser Ser Val Leu Pro Ala 
                485                 490                 495     


Met Val Asn Pro Thr Val Phe Phe His Ile Ser Val Asp Gly Glu Ser 
            500                 505                 510         


Leu Gly Arg Ile Ser Phe Glu Leu Phe Ala Asp Lys Phe Pro Lys Thr 
        515                 520                 525             


Ala Glu Asn Phe Cys Ala Leu Asn Thr Gly Glu Lys Gly Phe Gly Tyr 
    530                 535                 540                 


Lys Gly Cys Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys His Gly 
545                 550                 555                 560 


Gly Asp Phe Thr His His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
                565                 570                 575     


Glu Lys Val Asp Asp Asp Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
            580                 585                 590         


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
        595                 600                 605             


Cys Gly Gly His Gly Ala Leu Trp Val Gln Glu Trp Gln Asp Gln Gln 
    610                 615                 620                 


Glu Gly His His Ser 
625                 


<210>  207
<211>  2754
<212>  DNA
<213>  Homosapiens

<400>  207
gggctccgga gcacatgctg agcggagcgg ctggggctgc gcggcgtggc ggagcagcgc     60

tcgctccctc gctcactcgc tcgctcgcag ggacacacgc aggggctgac agctgtgctg    120

gtgctgataa gggaagccac aaggagacga tcgaggagag agacaagcgg cagcagaggc    180

agcagcggca gaggcagcac cagggctgcg gagctgctgg gagtgggagt gactccccca    240

cctcgggccc ccaccctgtc cctgtcctct tcccgcttgc cctgagttta gaagagcagc    300

cgctgccacc actgccactc gggagggcac cagggctgct ggctagggag ggacagggca    360

gggaggctct ggccagtccc agcagccggg gacagatgcc gatcgagatt gtgtgcaaaa    420

tcaaatttgc tgaggaggat gcgaaaccca aggagaagga ggcaggggat gagcagagcc    480

tcctcggggc tgttgcccct ggagcagccc cccgagacct ggccaccttt gccagcacca    540

gcaccctgca tggactgggc cgggcctgtg gcccaggccc ccacggactg cgcagaaccc    600

tgtgggcact ggccctactc acctcgctgg ctgccttcct gtaccaggcg gctggcctgg    660

cccggggcta cctgacccgg cctcacctgg tggcaatgga ccccgctgcc ccagccccag    720

tggcgggctt cccggctgtc accctctgca atatcaaccg cttccggcat tcggcactca    780

gcgatgccga catcttccac ctggccaatc tgacagggct gccccccaaa gaccgggatg    840

ggcaccgtgc ggctggcctg cgctacccag agcctgacat ggtagacatc ctcaaccgca    900

ctggccacca gctcgccgac atgcttaaga gctgcaactt cagtgggcat cactgctccg    960

ccagcaactt ctctgtggtc tatactcgct atgggaagtg ttacaccttc aacgcggacc   1020

cgcggagctc gctgcccagc cgggcagggg gcatgggcag tggcctggag atcatgctgg   1080

acatccagca ggaggagtac ctgcccatct ggagggagac aaatgagacg tcgtttgagg   1140

caggtattcg ggtgcagatc cacagccagg aggagccgcc ctacatccac cagctggggt   1200

tcggggtgtc cccaggcttc cagacctttg tgtcctgcca ggaacagcgg ctgacctacc   1260

tgccccagcc ctggggcaac tgccgcgcag agagtgagct cagggagcct gagcttcagg   1320

gctactcggc ctacagtgtg tctgcctgcc ggctgcgctg tgaaaaggag gccgtgcttc   1380

agcgctgcca ctgccggatg gtgcacatgc caggcaatga gaccatctgc ccaccaaata   1440

tctacatcga gtgtgcagac cacacactgg actccctggg tgggggccct gagggcccgt   1500

gcttctgccc caccccctgc aacctgacac gctatgggaa agagatctcc atggtcagga   1560

tccccaacag gggctcagcc cggtacctgg cgaggaagta caaccgcaac gagacctaca   1620

tacgggagaa cttcctggtc ctagatgtct tctttgaggc cctgacctct gaagccatgg   1680

agcagcgagc agcctatggc ctgtcagccc tgctgggaga cctcggggga cagatgggcc   1740

tgttcattgg ggccagcatc ctcacgttgc tggagatcct cgactacatc tatgaggtgt   1800

cctgggatcg actgaagcgg gtatggaggc gtcccaagac ccccctgcgg acctccactg   1860

ggggcatctc cactttgggg cttcaggagc tgaaggaaca gagtccctgc ccgagcctgg   1920

gccgagcgga gggtgggggg gtcagcagtc tgctccccaa tcaccaccac ccccacggtc   1980

ccccaggagg tctctttgaa gattttgctt gctaggacgg tgctgtgact gaaaggaccc   2040

aggagtctgg gacccctcct gggatcccca gcacattctc ctgctcctgg gagaggcctg   2100

ggggcggtgc tcactgggag ggccaggact cagttcctgc tctcatcctc ccctgccctg   2160

atgtcagctg ctttgcacaa aggtccttct tgtccacacc ccttatcccc aggctggtgc   2220

cccgggaggg ctggagacca ggccatgggc cctcacggag aggaagggaa ggaaggagag   2280

ggagggggag gatagagccc atcccagccg gggaggggga gccctctgta catttgtaaa   2340

tatttaggga aagccgggtg gggggagggg atacagatgt agaaggtggg tagggctaca   2400

ggggtgggtg atttagggac agccagggtc ccagccccaa tgtcagcagg atagggagag   2460

ccccaggact caggagtgct gggctggtcc tacttcctgc ccctctccag gcccagctcc   2520

cctcttggca gggggagagg atggcccagc aggcctggcc cagctcccag ttccccctgc   2580

accagcccca cccctagagt cccttctata gggagggggc aggagacctt ccagacttcg   2640

gctgagcttg gagggtggga agggagcctt ctcagtcctc tctccctcca gtctgatttt   2700

ataaagtgct gacgagattg ggaataaaga ggcataaaga aaaaaaaaaa aaaa         2754


<210>  208
<211>  666
<212>  PRT
<213>  Homosapiens

<400>  208

Met Leu Ser Gly Ala Ala Gly Ala Ala Arg Arg Gly Gly Ala Ala Leu 
1               5                   10                  15      


Ala Pro Ser Leu Thr Arg Ser Leu Ala Gly Thr His Ala Gly Ala Asp 
            20                  25                  30          


Ser Cys Ala Gly Ala Asp Lys Gly Ser His Lys Glu Thr Ile Glu Glu 
        35                  40                  45              


Arg Asp Lys Arg Gln Gln Arg Gln Gln Arg Gln Arg Gln His Gln Gly 
    50                  55                  60                  


Cys Gly Ala Ala Gly Ser Gly Ser Asp Ser Pro Thr Ser Gly Pro His 
65                  70                  75                  80  


Pro Val Pro Val Leu Phe Pro Leu Ala Leu Ser Leu Glu Glu Gln Pro 
                85                  90                  95      


Leu Pro Pro Leu Pro Leu Gly Arg Ala Pro Gly Leu Leu Ala Arg Glu 
            100                 105                 110         


Gly Gln Gly Arg Glu Ala Leu Ala Ser Pro Ser Ser Arg Gly Gln Met 
        115                 120                 125             


Pro Ile Glu Ile Val Cys Lys Ile Lys Phe Ala Glu Glu Asp Ala Lys 
    130                 135                 140                 


Pro Lys Glu Lys Glu Ala Gly Asp Glu Gln Ser Leu Leu Gly Ala Val 
145                 150                 155                 160 


Ala Pro Gly Ala Ala Pro Arg Asp Leu Ala Thr Phe Ala Ser Thr Ser 
                165                 170                 175     


Thr Leu His Gly Leu Gly Arg Ala Cys Gly Pro Gly Pro His Gly Leu 
            180                 185                 190         


Arg Arg Thr Leu Trp Ala Leu Ala Leu Leu Thr Ser Leu Ala Ala Phe 
        195                 200                 205             


Leu Tyr Gln Ala Ala Gly Leu Ala Arg Gly Tyr Leu Thr Arg Pro His 
    210                 215                 220                 


Leu Val Ala Met Asp Pro Ala Ala Pro Ala Pro Val Ala Gly Phe Pro 
225                 230                 235                 240 


Ala Val Thr Leu Cys Asn Ile Asn Arg Phe Arg His Ser Ala Leu Ser 
                245                 250                 255     


Asp Ala Asp Ile Phe His Leu Ala Asn Leu Thr Gly Leu Pro Pro Lys 
            260                 265                 270         


Asp Arg Asp Gly His Arg Ala Ala Gly Leu Arg Tyr Pro Glu Pro Asp 
        275                 280                 285             


Met Val Asp Ile Leu Asn Arg Thr Gly His Gln Leu Ala Asp Met Leu 
    290                 295                 300                 


Lys Ser Cys Asn Phe Ser Gly His His Cys Ser Ala Ser Asn Phe Ser 
305                 310                 315                 320 


Val Val Tyr Thr Arg Tyr Gly Lys Cys Tyr Thr Phe Asn Ala Asp Pro 
                325                 330                 335     


Arg Ser Ser Leu Pro Ser Arg Ala Gly Gly Met Gly Ser Gly Leu Glu 
            340                 345                 350         


Ile Met Leu Asp Ile Gln Gln Glu Glu Tyr Leu Pro Ile Trp Arg Glu 
        355                 360                 365             


Thr Asn Glu Thr Ser Phe Glu Ala Gly Ile Arg Val Gln Ile His Ser 
    370                 375                 380                 


Gln Glu Glu Pro Pro Tyr Ile His Gln Leu Gly Phe Gly Val Ser Pro 
385                 390                 395                 400 


Gly Phe Gln Thr Phe Val Ser Cys Gln Glu Gln Arg Leu Thr Tyr Leu 
                405                 410                 415     


Pro Gln Pro Trp Gly Asn Cys Arg Ala Glu Ser Glu Leu Arg Glu Pro 
            420                 425                 430         


Glu Leu Gln Gly Tyr Ser Ala Tyr Ser Val Ser Ala Cys Arg Leu Arg 
        435                 440                 445             


Cys Glu Lys Glu Ala Val Leu Gln Arg Cys His Cys Arg Met Val His 
    450                 455                 460                 


Met Pro Gly Asn Glu Thr Ile Cys Pro Pro Asn Ile Tyr Ile Glu Cys 
465                 470                 475                 480 


Ala Asp His Thr Leu Asp Ser Leu Gly Gly Gly Pro Glu Gly Pro Cys 
                485                 490                 495     


Phe Cys Pro Thr Pro Cys Asn Leu Thr Arg Tyr Gly Lys Glu Ile Ser 
            500                 505                 510         


Met Val Arg Ile Pro Asn Arg Gly Ser Ala Arg Tyr Leu Ala Arg Lys 
        515                 520                 525             


Tyr Asn Arg Asn Glu Thr Tyr Ile Arg Glu Asn Phe Leu Val Leu Asp 
    530                 535                 540                 


Val Phe Phe Glu Ala Leu Thr Ser Glu Ala Met Glu Gln Arg Ala Ala 
545                 550                 555                 560 


Tyr Gly Leu Ser Ala Leu Leu Gly Asp Leu Gly Gly Gln Met Gly Leu 
                565                 570                 575     


Phe Ile Gly Ala Ser Ile Leu Thr Leu Leu Glu Ile Leu Asp Tyr Ile 
            580                 585                 590         


Tyr Glu Val Ser Trp Asp Arg Leu Lys Arg Val Trp Arg Arg Pro Lys 
        595                 600                 605             


Thr Pro Leu Arg Thr Ser Thr Gly Gly Ile Ser Thr Leu Gly Leu Gln 
    610                 615                 620                 


Glu Leu Lys Glu Gln Ser Pro Cys Pro Ser Leu Gly Arg Ala Glu Gly 
625                 630                 635                 640 


Gly Gly Val Ser Ser Leu Leu Pro Asn His His His Pro His Gly Pro 
                645                 650                 655     


Pro Gly Gly Leu Phe Glu Asp Phe Ala Cys 
            660                 665     


<210>  209
<211>  2697
<212>  DNA
<213>  Homosapiens

<400>  209
gggctccgga gcacatgctg agcggagcgg ctggggctgc gcggcgtggc ggagcagcgc     60

tcgctccctc gctcactcgc tcgctcgcag ggacacacgc aggggctgac agctgtgctg    120

gtgctgataa gggaagccac aaggagacga tcgaggagag agacaagcgg cagcagaggc    180

agcagcggca gaggcagcac cagggctgcg gagctgctgg gagtgggagt gactccccca    240

cctcgggccc ccaccctgtc cctgtcctct tcccgcttgc cctgagttta gaagagcagc    300

cgctgccacc actgccactc gggagggcac cagggctgct ggctagggag ggacagggca    360

gggaggctct ggccagtccc agcagccggg gacagatgcc gatcgagatt gtgtgcaaaa    420

tcaaatttgc tgaggaggat gcgaaaccca aggagaagga ggcaggggat gagcagagcc    480

tcctcggggc tgttgcccct ggagcagccc cccgagacct ggccaccttt gccagcacca    540

gcaccctgca tggactgggc cgggcctgtg gcccaggccc ccacggactg cgcagaaccc    600

tgtgggcact ggccctactc acctcgctgg ctgccttcct gtaccaggcg gctggcctgg    660

cccggggcta cctgacccgg cctcacctgg tggcaatgga ccccgctgcc ccagccccag    720

tggcgggctt cccggctgtc accctctgca atatcaaccg cttccggcat tcggcactca    780

gcgatgccga catcttccac ctggccaatc tgacagggct gccccccaaa gaccgggatg    840

ggcaccgtgc ggctggcctg cgctacccag agcctgacat ggtagacatc ctcaaccgca    900

ctggccacca gctcgccgac atgcttaaga gctgcaactt cagtgggcat cactgctccg    960

ccagcaactt ctctgtggtc tatactcgct atgggaagtg ttacaccttc aacgcggacc   1020

cgcggagctc gctgcccagc cgggcagggg gcatgggcag tggcctggag atcatgctgg   1080

acatccagca ggaggagtac ctgcccatct ggagggagac aaatgagacg tcgtttgagg   1140

caggtattcg ggtgcagatc cacagccagg aggagccgcc ctacatccac cagctggggt   1200

tcggggtgtc cccaggcttc cagacctttg tgtcctgcca ggaacagcgg ctgacctacc   1260

tgccccagcc ctggggcaac tgccgcgcag agagtgagct cagggagcct gagcttcagg   1320

gctactcggc ctacagtgtg tctgcctgcc ggctgcgctg tgaaaaggag gccgtgcttc   1380

agcgctgcca ctgccggatg gtgcacatgc cagactccct gggtgggggc cctgagggcc   1440

cgtgcttctg ccccaccccc tgcaacctga cacgctatgg gaaagagatc tccatggtca   1500

ggatccccaa caggggctca gcccggtacc tggcgaggaa gtacaaccgc aacgagacct   1560

acatacggga gaacttcctg gtcctagatg tcttctttga ggccctgacc tctgaagcca   1620

tggagcagcg agcagcctat ggcctgtcag ccctgctggg agacctcggg ggacagatgg   1680

gcctgttcat tggggccagc atcctcacgt tgctggagat cctcgactac atctatgagg   1740

tgtcctggga tcgactgaag cgggtatgga ggcgtcccaa gacccccctg cggacctcca   1800

ctgggggcat ctccactttg gggcttcagg agctgaagga acagagtccc tgcccgagcc   1860

tgggccgagc ggagggtggg ggggtcagca gtctgctccc caatcaccac cacccccacg   1920

gtcccccagg aggtctcttt gaagattttg cttgctagga cggtgctgtg actgaaagga   1980

cccaggagtc tgggacccct cctgggatcc ccagcacatt ctcctgctcc tgggagaggc   2040

ctgggggcgg tgctcactgg gagggccagg actcagttcc tgctctcatc ctcccctgcc   2100

ctgatgtcag ctgctttgca caaaggtcct tcttgtccac accccttatc cccaggctgg   2160

tgccccggga gggctggaga ccaggccatg ggccctcacg gagaggaagg gaaggaagga   2220

gagggagggg gaggatagag cccatcccag ccggggaggg ggagccctct gtacatttgt   2280

aaatatttag ggaaagccgg gtggggggag gggatacaga tgtagaaggt gggtagggct   2340

acaggggtgg gtgatttagg gacagccagg gtcccagccc caatgtcagc aggataggga   2400

gagccccagg actcaggagt gctgggctgg tcctacttcc tgcccctctc caggcccagc   2460

tcccctcttg gcagggggag aggatggccc agcaggcctg gcccagctcc cagttccccc   2520

tgcaccagcc ccacccctag agtcccttct atagggaggg ggcaggagac cttccagact   2580

tcggctgagc ttggagggtg ggaagggagc cttctcagtc ctctctccct ccagtctgat   2640

tttataaagt gctgacgaga ttgggaataa agaggcataa agaaaaaaaa aaaaaaa      2697


<210>  210
<211>  647
<212>  PRT
<213>  Homosapiens

<400>  210

Met Leu Ser Gly Ala Ala Gly Ala Ala Arg Arg Gly Gly Ala Ala Leu 
1               5                   10                  15      


Ala Pro Ser Leu Thr Arg Ser Leu Ala Gly Thr His Ala Gly Ala Asp 
            20                  25                  30          


Ser Cys Ala Gly Ala Asp Lys Gly Ser His Lys Glu Thr Ile Glu Glu 
        35                  40                  45              


Arg Asp Lys Arg Gln Gln Arg Gln Gln Arg Gln Arg Gln His Gln Gly 
    50                  55                  60                  


Cys Gly Ala Ala Gly Ser Gly Ser Asp Ser Pro Thr Ser Gly Pro His 
65                  70                  75                  80  


Pro Val Pro Val Leu Phe Pro Leu Ala Leu Ser Leu Glu Glu Gln Pro 
                85                  90                  95      


Leu Pro Pro Leu Pro Leu Gly Arg Ala Pro Gly Leu Leu Ala Arg Glu 
            100                 105                 110         


Gly Gln Gly Arg Glu Ala Leu Ala Ser Pro Ser Ser Arg Gly Gln Met 
        115                 120                 125             


Pro Ile Glu Ile Val Cys Lys Ile Lys Phe Ala Glu Glu Asp Ala Lys 
    130                 135                 140                 


Pro Lys Glu Lys Glu Ala Gly Asp Glu Gln Ser Leu Leu Gly Ala Val 
145                 150                 155                 160 


Ala Pro Gly Ala Ala Pro Arg Asp Leu Ala Thr Phe Ala Ser Thr Ser 
                165                 170                 175     


Thr Leu His Gly Leu Gly Arg Ala Cys Gly Pro Gly Pro His Gly Leu 
            180                 185                 190         


Arg Arg Thr Leu Trp Ala Leu Ala Leu Leu Thr Ser Leu Ala Ala Phe 
        195                 200                 205             


Leu Tyr Gln Ala Ala Gly Leu Ala Arg Gly Tyr Leu Thr Arg Pro His 
    210                 215                 220                 


Leu Val Ala Met Asp Pro Ala Ala Pro Ala Pro Val Ala Gly Phe Pro 
225                 230                 235                 240 


Ala Val Thr Leu Cys Asn Ile Asn Arg Phe Arg His Ser Ala Leu Ser 
                245                 250                 255     


Asp Ala Asp Ile Phe His Leu Ala Asn Leu Thr Gly Leu Pro Pro Lys 
            260                 265                 270         


Asp Arg Asp Gly His Arg Ala Ala Gly Leu Arg Tyr Pro Glu Pro Asp 
        275                 280                 285             


Met Val Asp Ile Leu Asn Arg Thr Gly His Gln Leu Ala Asp Met Leu 
    290                 295                 300                 


Lys Ser Cys Asn Phe Ser Gly His His Cys Ser Ala Ser Asn Phe Ser 
305                 310                 315                 320 


Val Val Tyr Thr Arg Tyr Gly Lys Cys Tyr Thr Phe Asn Ala Asp Pro 
                325                 330                 335     


Arg Ser Ser Leu Pro Ser Arg Ala Gly Gly Met Gly Ser Gly Leu Glu 
            340                 345                 350         


Ile Met Leu Asp Ile Gln Gln Glu Glu Tyr Leu Pro Ile Trp Arg Glu 
        355                 360                 365             


Thr Asn Glu Thr Ser Phe Glu Ala Gly Ile Arg Val Gln Ile His Ser 
    370                 375                 380                 


Gln Glu Glu Pro Pro Tyr Ile His Gln Leu Gly Phe Gly Val Ser Pro 
385                 390                 395                 400 


Gly Phe Gln Thr Phe Val Ser Cys Gln Glu Gln Arg Leu Thr Tyr Leu 
                405                 410                 415     


Pro Gln Pro Trp Gly Asn Cys Arg Ala Glu Ser Glu Leu Arg Glu Pro 
            420                 425                 430         


Glu Leu Gln Gly Tyr Ser Ala Tyr Ser Val Ser Ala Cys Arg Leu Arg 
        435                 440                 445             


Cys Glu Lys Glu Ala Val Leu Gln Arg Cys His Cys Arg Met Val His 
    450                 455                 460                 


Met Pro Asp Ser Leu Gly Gly Gly Pro Glu Gly Pro Cys Phe Cys Pro 
465                 470                 475                 480 


Thr Pro Cys Asn Leu Thr Arg Tyr Gly Lys Glu Ile Ser Met Val Arg 
                485                 490                 495     


Ile Pro Asn Arg Gly Ser Ala Arg Tyr Leu Ala Arg Lys Tyr Asn Arg 
            500                 505                 510         


Asn Glu Thr Tyr Ile Arg Glu Asn Phe Leu Val Leu Asp Val Phe Phe 
        515                 520                 525             


Glu Ala Leu Thr Ser Glu Ala Met Glu Gln Arg Ala Ala Tyr Gly Leu 
    530                 535                 540                 


Ser Ala Leu Leu Gly Asp Leu Gly Gly Gln Met Gly Leu Phe Ile Gly 
545                 550                 555                 560 


Ala Ser Ile Leu Thr Leu Leu Glu Ile Leu Asp Tyr Ile Tyr Glu Val 
                565                 570                 575     


Ser Trp Asp Arg Leu Lys Arg Val Trp Arg Arg Pro Lys Thr Pro Leu 
            580                 585                 590         


Arg Thr Ser Thr Gly Gly Ile Ser Thr Leu Gly Leu Gln Glu Leu Lys 
        595                 600                 605             


Glu Gln Ser Pro Cys Pro Ser Leu Gly Arg Ala Glu Gly Gly Gly Val 
    610                 615                 620                 


Ser Ser Leu Leu Pro Asn His His His Pro His Gly Pro Pro Gly Gly 
625                 630                 635                 640 


Leu Phe Glu Asp Phe Ala Cys 
                645         


<210>  211
<211>  2956
<212>  DNA
<213>  Homosapiens

<400>  211
cgaggcgcgg ctccggggat tcggctcggg ccgctggctc tgctctgcgg ggagggagcg     60

ggcccgcccg cggggcccga gccctccgga tccgccccct ccccggtccc gccccctcgg    120

agactcctct ggctgctctg ggggttcgcc ggggccgggg acccgcggtc cgggcgccat    180

gcgggcatcg ctgctgctgt cggtgctgcg gcccgcaggg cccgtggccg tgggcatctc    240

cctgggcttc accctgagcc tgctcagcgt cacctgggtg gaggagccgt gcggcccagg    300

cccgccccaa cctggagact ctgagctgcc gccgcgcggc aacaccaacg cggcgcgccg    360

gcccaactcg gtgcagcccg gagcggagcg cgagaagccc ggggccggcg aaggcgccgg    420

ggagaattgg gagccgcgcg tcttgcccta ccaccctgca cagcccggcc aggccgccaa    480

aaaggccgtc aggacccgct acatcagcac ggagctgggc atcaggcaga ggctgctggt    540

ggcggtgctg acctctcaga ccacgctgcc cacgctgggc gtggccgtga accgcacgct    600

ggggcaccgg ctggagcgtg tggtgttcct gacgggcgca cggggccgcc gggccccacc    660

tggcatggca gtggtgacgc tgggcgagga gcgacccatt ggacacctgc acctggcgct    720

gcgccacctg ctggagcagc acggcgacga ctttgactgg ttcttcctgg tgcctgacac    780

cacctacacc gaggcgcacg gcctggcacg cctaactggc cacctcagtc tggcctccgc    840

cgcccacctg tacctgggcc ggccccagga cttcatcggc ggagagccca cccccggccg    900

ctactgccac ggaggctttg gggtgctgct gtcgcgcatg ctgctgcaac aactgcgccc    960

ccacctggaa ggctgccgca acgacatcgt cagtgcgcgc cctgacgagt ggctgggtcg   1020

ctgcattctc gatgccaccg gggtgggctg cactggtgac cacgaggggg tgcactatag   1080

ccatctggag ctgagccctg gggagccagt gcaggagggg gaccctcatt tccgaagtgc   1140

cctgacagcc caccctgtgc gtgaccctgt gcacatgtac cagctgcaca aagctttcgc   1200

ccgagctgaa ctggaacgca cgtaccagga gatccaggag ttacagtggg agatccagaa   1260

taccagccat ctggccgttg atggggaccg ggcagctgct tggcccgtgg gtattccagc   1320

accatcccgc ccggcctccc gctttgaggt gctgcgctgg gactacttca cggagcagca   1380

cgctttctcc tgcgccgatg gctcaccccg ctgcccactg cgtggggctg accgggctga   1440

tgtggccgat gttctgggga cagctctaga ggagctgaac cgccgctacc acccggcctt   1500

gcggctccag aagcagcagc tggtgaatgg ctaccgacgc tttgatccgg cccggggtat   1560

ggaatacacg ctggacttgc agctggaggc actgaccccc cagggaggcc gccggcccct   1620

cactcgccga gtgcagctgc tccggccgct gagccgcgtg gagatcttgc ctgtgcccta   1680

tgtcactgag gcctcacgtc tcactgtgct gctgcctcta gctgcggctg agcgtgacct   1740

ggcccctggc ttcttggagg cctttgccac tgcagcactg gagcctggtg atgctgcggc   1800

agccctgacc ctgctgctac tgtatgagcc gcgccaggcc cagcgcgtgg cccatgcaga   1860

tgtcttcgca cctgtcaagg cccacgtggc agagctggag cggcgtttcc ccggtgcccg   1920

ggtgccatgg ctcagtgtgc agacagccgc accctcacca ctgcgcctca tggatctact   1980

ctccaagaag cacccgctgg acacactgtt cctgctggcc gggccagaca cggtgctcac   2040

gcctgacttc ctgaaccgct gccgcatgca tgccatctcc ggctggcagg ccttctttcc   2100

catgcatttc caagccttcc acccagctgt ggccccacca caagggcctg ggcccccaga   2160

gctgggccgt gacactggcc gctttgatcg ccaggcagcc agcgaggcct gcttctacaa   2220

ctccgactac gtggcagccc gtgggcgcct ggcggcagcc tcagaacaag aagaggagct   2280

gctggagagc ctggatgtgt acgagctgtt cctccacttc tccagtctgc atgtgctgcg   2340

ggcggtggag ccggcgctgc tgcagcgcta ccgggcccag acgtgcagcg cgaggctcag   2400

tgaggacctg taccaccgct gcctccagag cgtgcttgag ggcctcggct cccgaaccca   2460

gctggccatg ctactctttg aacaggagca gggcaacagc acctgacccc accctgtccc   2520

cgtgggccgt ggcatggcca caccccaccc cacttctccc ccaaaaccag agccacctgc   2580

cagcctcgct gggcagggct ggccgtagcc agaccccaag ctggcccact ggtcccctct   2640

ctggctctgt gggtccctgg gctctggaca agcactgggg gacgtgcccc cagagccacc   2700

cacttctcat cccaaaccca gtttccctgc cccctgacgc tgctgattcg ggctgtggcc   2760

tccacgtatt tatgcagtac agtctgcctg acgccagccc tgcctctggg ccctgggggc   2820

tgggctgtag aagagttgtt ggggaaggag ggagctgagg agggggcatc tcccaacttc   2880

tcccttttgg accctgccga agctccctgc ctttaataaa ctggccaagt gtgaaaaaaa   2940

aaaaaaaaaa aaaaaa                                                   2956


<210>  212
<211>  775
<212>  PRT
<213>  Homosapiens

<400>  212

Met Arg Ala Ser Leu Leu Leu Ser Val Leu Arg Pro Ala Gly Pro Val 
1               5                   10                  15      


Ala Val Gly Ile Ser Leu Gly Phe Thr Leu Ser Leu Leu Ser Val Thr 
            20                  25                  30          


Trp Val Glu Glu Pro Cys Gly Pro Gly Pro Pro Gln Pro Gly Asp Ser 
        35                  40                  45              


Glu Leu Pro Pro Arg Gly Asn Thr Asn Ala Ala Arg Arg Pro Asn Ser 
    50                  55                  60                  


Val Gln Pro Gly Ala Glu Arg Glu Lys Pro Gly Ala Gly Glu Gly Ala 
65                  70                  75                  80  


Gly Glu Asn Trp Glu Pro Arg Val Leu Pro Tyr His Pro Ala Gln Pro 
                85                  90                  95      


Gly Gln Ala Ala Lys Lys Ala Val Arg Thr Arg Tyr Ile Ser Thr Glu 
            100                 105                 110         


Leu Gly Ile Arg Gln Arg Leu Leu Val Ala Val Leu Thr Ser Gln Thr 
        115                 120                 125             


Thr Leu Pro Thr Leu Gly Val Ala Val Asn Arg Thr Leu Gly His Arg 
    130                 135                 140                 


Leu Glu Arg Val Val Phe Leu Thr Gly Ala Arg Gly Arg Arg Ala Pro 
145                 150                 155                 160 


Pro Gly Met Ala Val Val Thr Leu Gly Glu Glu Arg Pro Ile Gly His 
                165                 170                 175     


Leu His Leu Ala Leu Arg His Leu Leu Glu Gln His Gly Asp Asp Phe 
            180                 185                 190         


Asp Trp Phe Phe Leu Val Pro Asp Thr Thr Tyr Thr Glu Ala His Gly 
        195                 200                 205             


Leu Ala Arg Leu Thr Gly His Leu Ser Leu Ala Ser Ala Ala His Leu 
    210                 215                 220                 


Tyr Leu Gly Arg Pro Gln Asp Phe Ile Gly Gly Glu Pro Thr Pro Gly 
225                 230                 235                 240 


Arg Tyr Cys His Gly Gly Phe Gly Val Leu Leu Ser Arg Met Leu Leu 
                245                 250                 255     


Gln Gln Leu Arg Pro His Leu Glu Gly Cys Arg Asn Asp Ile Val Ser 
            260                 265                 270         


Ala Arg Pro Asp Glu Trp Leu Gly Arg Cys Ile Leu Asp Ala Thr Gly 
        275                 280                 285             


Val Gly Cys Thr Gly Asp His Glu Gly Val His Tyr Ser His Leu Glu 
    290                 295                 300                 


Leu Ser Pro Gly Glu Pro Val Gln Glu Gly Asp Pro His Phe Arg Ser 
305                 310                 315                 320 


Ala Leu Thr Ala His Pro Val Arg Asp Pro Val His Met Tyr Gln Leu 
                325                 330                 335     


His Lys Ala Phe Ala Arg Ala Glu Leu Glu Arg Thr Tyr Gln Glu Ile 
            340                 345                 350         


Gln Glu Leu Gln Trp Glu Ile Gln Asn Thr Ser His Leu Ala Val Asp 
        355                 360                 365             


Gly Asp Arg Ala Ala Ala Trp Pro Val Gly Ile Pro Ala Pro Ser Arg 
    370                 375                 380                 


Pro Ala Ser Arg Phe Glu Val Leu Arg Trp Asp Tyr Phe Thr Glu Gln 
385                 390                 395                 400 


His Ala Phe Ser Cys Ala Asp Gly Ser Pro Arg Cys Pro Leu Arg Gly 
                405                 410                 415     


Ala Asp Arg Ala Asp Val Ala Asp Val Leu Gly Thr Ala Leu Glu Glu 
            420                 425                 430         


Leu Asn Arg Arg Tyr His Pro Ala Leu Arg Leu Gln Lys Gln Gln Leu 
        435                 440                 445             


Val Asn Gly Tyr Arg Arg Phe Asp Pro Ala Arg Gly Met Glu Tyr Thr 
    450                 455                 460                 


Leu Asp Leu Gln Leu Glu Ala Leu Thr Pro Gln Gly Gly Arg Arg Pro 
465                 470                 475                 480 


Leu Thr Arg Arg Val Gln Leu Leu Arg Pro Leu Ser Arg Val Glu Ile 
                485                 490                 495     


Leu Pro Val Pro Tyr Val Thr Glu Ala Ser Arg Leu Thr Val Leu Leu 
            500                 505                 510         


Pro Leu Ala Ala Ala Glu Arg Asp Leu Ala Pro Gly Phe Leu Glu Ala 
        515                 520                 525             


Phe Ala Thr Ala Ala Leu Glu Pro Gly Asp Ala Ala Ala Ala Leu Thr 
    530                 535                 540                 


Leu Leu Leu Leu Tyr Glu Pro Arg Gln Ala Gln Arg Val Ala His Ala 
545                 550                 555                 560 


Asp Val Phe Ala Pro Val Lys Ala His Val Ala Glu Leu Glu Arg Arg 
                565                 570                 575     


Phe Pro Gly Ala Arg Val Pro Trp Leu Ser Val Gln Thr Ala Ala Pro 
            580                 585                 590         


Ser Pro Leu Arg Leu Met Asp Leu Leu Ser Lys Lys His Pro Leu Asp 
        595                 600                 605             


Thr Leu Phe Leu Leu Ala Gly Pro Asp Thr Val Leu Thr Pro Asp Phe 
    610                 615                 620                 


Leu Asn Arg Cys Arg Met His Ala Ile Ser Gly Trp Gln Ala Phe Phe 
625                 630                 635                 640 


Pro Met His Phe Gln Ala Phe His Pro Ala Val Ala Pro Pro Gln Gly 
                645                 650                 655     


Pro Gly Pro Pro Glu Leu Gly Arg Asp Thr Gly Arg Phe Asp Arg Gln 
            660                 665                 670         


Ala Ala Ser Glu Ala Cys Phe Tyr Asn Ser Asp Tyr Val Ala Ala Arg 
        675                 680                 685             


Gly Arg Leu Ala Ala Ala Ser Glu Gln Glu Glu Glu Leu Leu Glu Ser 
    690                 695                 700                 


Leu Asp Val Tyr Glu Leu Phe Leu His Phe Ser Ser Leu His Val Leu 
705                 710                 715                 720 


Arg Ala Val Glu Pro Ala Leu Leu Gln Arg Tyr Arg Ala Gln Thr Cys 
                725                 730                 735     


Ser Ala Arg Leu Ser Glu Asp Leu Tyr His Arg Cys Leu Gln Ser Val 
            740                 745                 750         


Leu Glu Gly Leu Gly Ser Arg Thr Gln Leu Ala Met Leu Leu Phe Glu 
        755                 760                 765             


Gln Glu Gln Gly Asn Ser Thr 
    770                 775 


<210>  213
<211>  2239
<212>  DNA
<213>  Homosapiens

<400>  213
gtgacgtcag gagcagaggc cggagctgtc catcagcacc aaaggccgcg ggcgggctca     60

gggcatgggg ccgcggttct ggggcggccc gagccccggc tcctgcgcct tccccttcct    120

caggcccagc ccgagttccc ggacgccgcg ggactggagt gccagccggt gttggacgtg    180

gagcggcgcc gccaccgcgc cgacaccatt ctctccggcc cagcagcccc cttcctcgca    240

cgacggactt tccctggacc ccagtcagtt ggagcctctg gcgccccgca accccggccc    300

ctcgggcctc tgcacagcct ctttcactca gaagctcagg tcgcctccag cccaggttaa    360

cttgggaggg tgactccctt ctattcccag cactatgccg gggactgtgg caacactgcg    420

gttccagctg ctgccccctg agccagatga tgccttctgg ggtgcacctt gtgaacagcc    480

cctggagcgc aggtaccagg cactgccggc cctcgtctgc atcatgtgct gtttgtttgg    540

agtcgtctac tgcttcttcg gttaccgctg cttcaaggca gtgctcttcc tcactgggtt    600

gctgtttggc tcggtggtca tcttcctcct ctgctaccga gagcgggtgc tagagacaca    660

gctgagtgct ggggcgagcg cgggcatcgc tctgggcatc gggctgctct gcgggctggt    720

ggccatgcta gtgcgcagcg tgggcctctt cctggtgggg ctgctgctcg gcctgctgct    780

cgcagctgct gccctgctgg gctccgcacc ctactaccag ccaggctccg tgtggggtcc    840

actggggctg ttgctggggg gcggcctgct ctgtgccctg ctcactctgc gctggccccg    900

cccactcacc accctggcca ccgccgtgac tggtgctgcg ctgatcgcca ctgccgctga    960

ctacttcgcc gagctgctac tgctggggcg ctacgtggtg gagcgactcc gggctgctcc   1020

tgtgccccca ctctgctggc gaagctgggc cctgctggca ctctggcccc tgctcagcct   1080

gatgggcgtt ctggtgcagt ggagggtgac agctgagggg gactcccaca cggaagtggt   1140

catcagccgg cagcgccgac gcgtgcaact gatgcggatt cggcagcagg aagatcgcaa   1200

ggagaaaagg cggaaaaaga gacctcctcg ggctcccctc agaggtcccc gggctcctcc   1260

caggcctggg ccaccagatc ctgcttatcg gcgcaggcca gtgcccatca aacgcttcaa   1320

tggagacgtc ctctccccga gctatatcca gagcttccga gaccggcaga ccgggagctc   1380

cctgagctcc ttcatggcct cacccacaga tgcggactat gagtatgggt cccggggacc   1440

tctgacagcc tgctcaggcc ccccagtgcg ggtatagcca tatctgtctg tctagactct   1500

gcagtcacca gctctgccag ctcgaggagg cctgctaggc tgccactcag cctcctggct   1560

ttggctgtcc ctctccccag cctggagagg gctggcctgg tcactagaag ggaggattgt   1620

ctcaggcgag tcttggcctg agaggaaagc cccctcccaa gctcccaaga ggctcctgag   1680

gaactcgggg tgtgaacccc attggggtgt gctcagggtt gtgagtgtgt tgcccgtgtg   1740

tctgtgtgta tgtgtgtggg ggtgggcagg cttggagggg acgctgggac ccttgcctta   1800

gatttctgac tggtagggtt tctccaggct cagccccacc tcttcactcc ctgccaaggt   1860

cccatgggcc acctcctgca tgtctccgcg gaggggctac cttccttccc atcgccctgc   1920

ctcgcagcca gactcatcta agggttcttg tccttgtcta tggggcaaac tgtagcatcc   1980

ctcaccctgg tcccctggcc tctgtaaagc caccagcctg agggcagtgg caggagatgg   2040

gggtgggggg gtgctgctct gggctgggtt gggaagggag ttggggaggg gtttaaatgc   2100

acggtgcatg tctggtgtct gtcatgccaa cctagacacc tcatgcttct gtctccccca   2160

ccccactctg ttttacatct tttataaatg tgccaaactg tgtggcctct gccaggaaaa   2220

aaaaaaaaaa aaaaaaaaa                                                2239


<210>  214
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  214

Met Pro Gly Thr Val Ala Thr Leu Arg Phe Gln Leu Leu Pro Pro Glu 
1               5                   10                  15      


Pro Asp Asp Ala Phe Trp Gly Ala Pro Cys Glu Gln Pro Leu Glu Arg 
            20                  25                  30          


Arg Tyr Gln Ala Leu Pro Ala Leu Val Cys Ile Met Cys Cys Leu Phe 
        35                  40                  45              


Gly Val Val Tyr Cys Phe Phe Gly Tyr Arg Cys Phe Lys Ala Val Leu 
    50                  55                  60                  


Phe Leu Thr Gly Leu Leu Phe Gly Ser Val Val Ile Phe Leu Leu Cys 
65                  70                  75                  80  


Tyr Arg Glu Arg Val Leu Glu Thr Gln Leu Ser Ala Gly Ala Ser Ala 
                85                  90                  95      


Gly Ile Ala Leu Gly Ile Gly Leu Leu Cys Gly Leu Val Ala Met Leu 
            100                 105                 110         


Val Arg Ser Val Gly Leu Phe Leu Val Gly Leu Leu Leu Gly Leu Leu 
        115                 120                 125             


Leu Ala Ala Ala Ala Leu Leu Gly Ser Ala Pro Tyr Tyr Gln Pro Gly 
    130                 135                 140                 


Ser Val Trp Gly Pro Leu Gly Leu Leu Leu Gly Gly Gly Leu Leu Cys 
145                 150                 155                 160 


Ala Leu Leu Thr Leu Arg Trp Pro Arg Pro Leu Thr Thr Leu Ala Thr 
                165                 170                 175     


Ala Val Thr Gly Ala Ala Leu Ile Ala Thr Ala Ala Asp Tyr Phe Ala 
            180                 185                 190         


Glu Leu Leu Leu Leu Gly Arg Tyr Val Val Glu Arg Leu Arg Ala Ala 
        195                 200                 205             


Pro Val Pro Pro Leu Cys Trp Arg Ser Trp Ala Leu Leu Ala Leu Trp 
    210                 215                 220                 


Pro Leu Leu Ser Leu Met Gly Val Leu Val Gln Trp Arg Val Thr Ala 
225                 230                 235                 240 


Glu Gly Asp Ser His Thr Glu Val Val Ile Ser Arg Gln Arg Arg Arg 
                245                 250                 255     


Val Gln Leu Met Arg Ile Arg Gln Gln Glu Asp Arg Lys Glu Lys Arg 
            260                 265                 270         


Arg Lys Lys Arg Pro Pro Arg Ala Pro Leu Arg Gly Pro Arg Ala Pro 
        275                 280                 285             


Pro Arg Pro Gly Pro Pro Asp Pro Ala Tyr Arg Arg Arg Pro Val Pro 
    290                 295                 300                 


Ile Lys Arg Phe Asn Gly Asp Val Leu Ser Pro Ser Tyr Ile Gln Ser 
305                 310                 315                 320 


Phe Arg Asp Arg Gln Thr Gly Ser Ser Leu Ser Ser Phe Met Ala Ser 
                325                 330                 335     


Pro Thr Asp Ala Asp Tyr Glu Tyr Gly Ser Arg Gly Pro Leu Thr Ala 
            340                 345                 350         


Cys Ser Gly Pro Pro Val Arg Val 
        355                 360 


<210>  215
<211>  6347
<212>  DNA
<213>  Homosapiens

<400>  215
atgtctgtgg ccatgagcct tatctcccac tcccgccagg gatctgcagg cgcctctgcc     60

actcaggccc aagcctggcg ggcggctggg gacctggcgg ctggaggtgg gagggaggag    120

ggggaagagg cccaagctgt gggagggggc tgggaagaga ggctcctaag agcaggaagc    180

caggcagcgg gcaggggagg ctgcggggcc actcgctgga gaggcaaaca ggaaggactg    240

ccccctgagc gccaggcttc gggcccggga atcgccgccg ccgccgccgc agagctgcag    300

ctcggggccg agggtaagga ggcgagccgg gagcgggagg cccgggagag ctccgcgggt    360

ccccgcgccc agtccccagc cgcgccccga ccccgccgcc ccgggcctcg gctcgccctc    420

cgcacccccc cctgcccccc caccgttcgc cgctgcaggc ggtcggccgc cgcgatgaag    480

gcgagctcgg gggatcaggg gagccccccg tgcttcctgc gcttcccgcg gcctgtgcgg    540

gtggtaagtg gcgccgaggc cgagctcaag tgcgtggtcc tgggggagcc gccgcctgta    600

gtggtgtggg agaagggcgg gcagcagctg gcggcctcgg aacgcctgag cttcccggcg    660

gacggcgcgg agcacggcct gctgctgacc gccgcactgc ccaccgacgc gggggtctac    720

gtgtgccgcg cccgcaacgc ggccggcgag gcctacgcgg cggccgccgt caccgtgctg    780

gagccgccgg cctccgaccc cgagctgcag cccgccgagc gcccgctgcc atcgccgggg    840

tccggggagg gcgccccggt cttcctcacg gggcctcgat cccagtgggt gctgcggggg    900

gcggaggtgg tgctgacgtg ccgggcgggg ggcctccccg agcccacact gtactgggag    960

aaggacggga tggccctgga cgaagtgtgg gacagcagcc acttcgcgct ccagccgggc   1020

cgcgccgagg acggccccgg cgcgagcctg gcactgcgca tcctggcggc tcggctgccg   1080

gattccggcg tctacgtgtg ccacgcccgc aacgcgcacg gccacgcgca ggcgggggcg   1140

ctgctccagg tgcaccagcc ccccgagagc ccgcccgcgg accccgacga ggcccccgcg   1200

ccggtggtgg agccgctcaa gtgcgcgcct aagaccttct gggtgaacga gggcaagcac   1260

gccaagttcc gctgctacgt gatgggcaag cccgagcccg agatcgaatg gcactgggag   1320

ggccgcccgc tgctcccgga ccgccgccgc ctcatgtacc gcgaccgcga cggcggcttc   1380

gtgctcaagg tgctttactg ccaggccaag gatcgtgggc tctacgtctg cgccgcgcgc   1440

aactcggcgg gccagacgct cagtgccgtg cagctgcacg tgaaagagcc ccgcctccgg   1500

ttcacacggc ccctgcagga cgtggagggc cgtgagcacg ggattgccgt gctggaatgt   1560

aaagtaccca actcccgcat ccccacggcc tggttccgtg aggaccagcg gctgctgccc   1620

tgccgcaagt acgagcagat cgaagagggc actgtccggc gcctcatcat ccacaggctg   1680

aaggcagacg atgatggtat ctacctgtgc gagatgcggg gccgggtgcg caccgtggcc   1740

aacgtcacag tcaaagggcc catcctgaag cgcctgcccc ggaagctcga cgtcctggaa   1800

ggagagaatg ctgtgctgct agtggaaact ctagaggccg gggtcgaggg acgctggagc   1860

cgtgatgggg aggagctgcc ggtcatctgc cagagcagct caggccacat gcatgccctg   1920

gtccttccag gggtcacccg agaggatgct ggcgaggtca cctttagcct gggcaactcc   1980

cgtaccacta cgcttctcag agtaaaatgt gtcaagcaca gtcccccagg accccccata   2040

ttggcagaga tgttcaaggg ccacaagaac acggtcctgt tgacctggaa gcctcccgag   2100

ccagctcccg agaccccatt catctaccgg ctggagcggc aggaagtggg ctctgaagac   2160

tggattcagt gcttcagcat cgagaaagcc ggagccgtgg aggtgccggg cgactgtgtg   2220

ccctccgagg gtgactaccg cttccgcatc tgcacagtca gcggacatgg ccgtagtccc   2280

cacgtggtgt tccacggttc tgctcacctt gtgcccacag ctcgcctggt ggcaggtctg   2340

gaggatgtgc aggtatacga cggggaagat gccgtcttct ccctcgatct ctccaccatc   2400

atccagggta cctggttcct taatggggaa gagctcaaga gtaacgagcc ggagggccag   2460

gtggaacctg gggccctgcg gtaccgtata gagcagaagg gtctgcagca cagactcatc   2520

ctgcatgccg tcaagcacca ggacagcggt gccctggtcg gcttcagctg ccccggcgtg   2580

caggactcag ctgccctcac aatccaagag agcccggtgc acatcctgag cccccaggac   2640

agggtgtcgt tgaccttcac aacctcagag cgggtggtgc tgacttgtga gctctcaagg   2700

gtggacttcc cggcaacctg gtacaaggat gggcagaagg tggaggagag cgagttgctg   2760

gtggtgaaga tggatgggcg caaacaccgt ctgatcctgc ctgaggccaa agtccaggac   2820

agtggcgagt ttgagtgcag gacagaaggg gtctcggcct tcttcggcgt cactgtccaa   2880

gatcctcccg tgcacatcgt ggacccccga gaacatgtgt tcgtgcatgc cataacttcc   2940

gagtgtgtca tgctggcctg tgaggtggac cgagaggacg cccctgtgcg ttggtacaag   3000

gacgggcagg aggtggagga gagtgacttc gtggtgctgg agaatgaggg gccccatcgc   3060

cgcctggtgc tgcccgccac ccagccctca gacgggggcg agtttcagtg cgtcgctgga   3120

gatgagtgtg cctacttcac tgtcaccatc acagacgtct cctcgtggat cgtgtatccc   3180

agcggcaagg tgtatgtggc agccgtgcgc ctggagcgtg tggtgctgac ctgtgagcta   3240

tgccggccct gggcagaggt gcgctggacc aaggatggag aggaggtggt ggagagcccc   3300

gcgctgctcc tgcagaagga agacactgtc cgccgcctgg tgctgcccgc tgtccagctc   3360

gaggactccg gcgagtactt gtgtgaaatt gacgatgagt cggcctcctt cactgtcacc   3420

gtcacagaac ccccagtgcg gatcatatac cctcgcgatg aggtgacctt gatcgccgtg   3480

accttggagt gtgtggtgct gatgtgtgaa ctgtctcggg aggatgcccc tgtgcgctgg   3540

tacaaggatg ggctggaagt ggaggagagc gaggccctgg tgctggagag ggatgggcca   3600

cgctgccgcc tggtgctacc tgctgctcag cccgaggacg ggggcgagtt tgtatgtgat   3660

gctggagatg actcggcctt cttcactgtc actgtcacag agcctccagt gcagttcctt   3720

gctctagaga caactccaag cccgctctgt gtggcccctg gggagccagt ggtgctgagc   3780

tgtgaactgt cccgggctgg cgcccccgtg gtctggagcc acaatgggag gcccgtgcag   3840

gagggcgagg gcctagagct ccatgccgag ggcccccgcc gagtcctctg catccaggct   3900

gcaggcccag cccatgcagg gctctacacc tgccagtctg gagcagcccc cggagcccca   3960

agcctcagct tcaccgtcca ggtggctgag ccccctgtgc gggtggtagc tcccgaggca   4020

gcccagacga gggttcggag caccccaggc ggggacctag agctggtggt gcacctctcc   4080

gggccagggg gccctgtacg ctggtacaag gacggggagc gactggcaag ccaggggcgg   4140

gtgcagctgg agcaggccgg ggccaggcag gtgctgcggg tgcagggggc acggagcggg   4200

gacgctgggg agtacctgtg cgatgcgccc caggacagcc gcatcttcct tgtcagcgtg   4260

gaagagccac tgctggtgaa gctggtctcg gagctgacac cactcactgt ccacgagggc   4320

gatgatgcca cgttccggtg tgaagtctcc ccaccagatg ccgatgtcac ctggctgcgc   4380

aatggggccg tcgtcactcc agggccccag agacagagct gctgttccta cggcggttgc   4440

aggatgtgcg ggcagaggaa ggccaggatg tgtgtctcga agtggagaca ggccgagtgg   4500

gtgcagcggg ggccgtgcgc tgggtgcgag gtgggcagcc cctgccccac gactctcgcc   4560

tgtccatggc ccaggatggg cacatccacc gcctcttcat ccatggtgtc atactggccg   4620

accagggcac ctacggctgc gagagccacc acgatcgcac cctggccagg ctcagcgtga   4680

ggcgacggga acgcgcttac gcctagcccg cggctccggc tccaggccct cggcacgcgc   4740

cgccttctcc agctgcgacg ctgcggcccc tcggacgccg ggacctacag ctgcgcggtg   4800

gggacggccc gcgccggacc ggtccgcctg accgtgcgcg gtgggtacgg ggtgatgtgg   4860

aggctgggca ctgctttggg cgcgagactt gcggagctgt cttccccgga ccctgatgac   4920

cgcgcgtgct tctagaaagg gggcgtggag ggggcgtgac cggtaactgc cctctgcccc   4980

gccccgctca cgccccgggc tccgccccag agcgtactgt ggcggtactc tccgagctgc   5040

ggtcggtgag cgcccgcgaa ggcgacggcg ctacgttcga gtgcaccgtg tcggaggtcg   5100

agaccacggg gcgctgggag ctcggaggcc gcccgctgag acccggagcc cgcgtccgca   5160

tccgacagga agggaagaaa cacattctgg tgcttagcga gctgcgcgcc gaggacgccg   5220

gtgaagtccg cttccaggcg gggcccgccc agtccctggc tctactggaa gtggaggcat   5280

tgcctctcca gatgtgccgc cacccccctc gcgagaagac cgttctggtg ggccgccggg   5340

cggtgctgga ggtgactgtg tcccgctcgg ggggccacgt gtgctggctg cgggaggggg   5400

ccgagctgtg cccgggagat aagtatgaga tgcgcagcca cggccccacc cacagcctgg   5460

tcatccatga cgttcgacct gaggaccaag gcacttactg ctgccaggcc ggccaggaca   5520

gcacccacac acggctgctg gtagagggtg agtaaagcca actgggcagc ggcaggaggg   5580

tgagggcgcc tgggagctga tgggttaagc cacacctatg ggaggctttc cagaacttgg   5640

ggtggcaacg ggtcctggga tacgtaggag gtggggatgg gggaggggag gggtagagca   5700

cacccagggc tggaaagccc tggaactgct tggctcagat cagctgctcc tggtcagctg   5760

ttcccacctt tctacgcccc ttcttgccag gcttctcctc tctcctgcca ctggaccatg   5820

tttgtctctc ttgaacagcc ctgtttctac cagttccttt cctccccact tcaccaacac   5880

tgccttcctc cagcctgtcc ctcctccttc ctgccctctg cccagcttgc ctctgcccat   5940

ctcagcaagt tccatgtcag ccttggcaga agcctctttc tttcctcttc cccataagag   6000

acatcccacc ttctatccca aatcccagca ttcccttcag gtgccgcgct gtgccccacc   6060

cctagctgac ccccaccttc ctgccgccaa gacagcccta accaaggccc agaaagggta   6120

gggcagaacc tgggggccca gctctttgtg tactggtgtc caggctctgc caggggagag   6180

gaaggtggta cccccttctc tccccagccc catgtggagt cattcctctg caggcaacta   6240

ggagaaccta accaggccag gcgggtgccc ttggacagct tggaaggcgt ttgcccttac   6300

cctgggcagg ggtagagaga caaggaacaa taaaagtgct acagctc                 6347


<210>  216
<211>  1559
<212>  PRT
<213>  Homosapiens

<400>  216

Met Ser Val Ala Met Ser Leu Ile Ser His Ser Arg Gln Gly Ser Ala 
1               5                   10                  15      


Gly Ala Ser Ala Thr Gln Ala Gln Ala Trp Arg Ala Ala Gly Asp Leu 
            20                  25                  30          


Ala Ala Gly Gly Gly Arg Glu Glu Gly Glu Glu Ala Gln Ala Val Gly 
        35                  40                  45              


Gly Gly Trp Glu Glu Arg Leu Leu Arg Ala Gly Ser Gln Ala Ala Gly 
    50                  55                  60                  


Arg Gly Gly Cys Gly Ala Thr Arg Trp Arg Gly Lys Gln Glu Gly Leu 
65                  70                  75                  80  


Pro Pro Glu Arg Gln Ala Ser Gly Pro Gly Ile Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Glu Leu Gln Leu Gly Ala Glu Gly Lys Glu Ala Ser Arg Glu Arg 
            100                 105                 110         


Glu Ala Arg Glu Ser Ser Ala Gly Pro Arg Ala Gln Ser Pro Ala Ala 
        115                 120                 125             


Pro Arg Pro Arg Arg Pro Gly Pro Arg Leu Ala Leu Arg Thr Pro Pro 
    130                 135                 140                 


Cys Pro Pro Thr Val Arg Arg Cys Arg Arg Ser Ala Ala Ala Met Lys 
145                 150                 155                 160 


Ala Ser Ser Gly Asp Gln Gly Ser Pro Pro Cys Phe Leu Arg Phe Pro 
                165                 170                 175     


Arg Pro Val Arg Val Val Ser Gly Ala Glu Ala Glu Leu Lys Cys Val 
            180                 185                 190         


Val Leu Gly Glu Pro Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln 
        195                 200                 205             


Gln Leu Ala Ala Ser Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu 
    210                 215                 220                 


His Gly Leu Leu Leu Thr Ala Ala Leu Pro Thr Asp Ala Gly Val Tyr 
225                 230                 235                 240 


Val Cys Arg Ala Arg Asn Ala Ala Gly Glu Ala Tyr Ala Ala Ala Ala 
                245                 250                 255     


Val Thr Val Leu Glu Pro Pro Ala Ser Asp Pro Glu Leu Gln Pro Ala 
            260                 265                 270         


Glu Arg Pro Leu Pro Ser Pro Gly Ser Gly Glu Gly Ala Pro Val Phe 
        275                 280                 285             


Leu Thr Gly Pro Arg Ser Gln Trp Val Leu Arg Gly Ala Glu Val Val 
    290                 295                 300                 


Leu Thr Cys Arg Ala Gly Gly Leu Pro Glu Pro Thr Leu Tyr Trp Glu 
305                 310                 315                 320 


Lys Asp Gly Met Ala Leu Asp Glu Val Trp Asp Ser Ser His Phe Ala 
                325                 330                 335     


Leu Gln Pro Gly Arg Ala Glu Asp Gly Pro Gly Ala Ser Leu Ala Leu 
            340                 345                 350         


Arg Ile Leu Ala Ala Arg Leu Pro Asp Ser Gly Val Tyr Val Cys His 
        355                 360                 365             


Ala Arg Asn Ala His Gly His Ala Gln Ala Gly Ala Leu Leu Gln Val 
    370                 375                 380                 


His Gln Pro Pro Glu Ser Pro Pro Ala Asp Pro Asp Glu Ala Pro Ala 
385                 390                 395                 400 


Pro Val Val Glu Pro Leu Lys Cys Ala Pro Lys Thr Phe Trp Val Asn 
                405                 410                 415     


Glu Gly Lys His Ala Lys Phe Arg Cys Tyr Val Met Gly Lys Pro Glu 
            420                 425                 430         


Pro Glu Ile Glu Trp His Trp Glu Gly Arg Pro Leu Leu Pro Asp Arg 
        435                 440                 445             


Arg Arg Leu Met Tyr Arg Asp Arg Asp Gly Gly Phe Val Leu Lys Val 
    450                 455                 460                 


Leu Tyr Cys Gln Ala Lys Asp Arg Gly Leu Tyr Val Cys Ala Ala Arg 
465                 470                 475                 480 


Asn Ser Ala Gly Gln Thr Leu Ser Ala Val Gln Leu His Val Lys Glu 
                485                 490                 495     


Pro Arg Leu Arg Phe Thr Arg Pro Leu Gln Asp Val Glu Gly Arg Glu 
            500                 505                 510         


His Gly Ile Ala Val Leu Glu Cys Lys Val Pro Asn Ser Arg Ile Pro 
        515                 520                 525             


Thr Ala Trp Phe Arg Glu Asp Gln Arg Leu Leu Pro Cys Arg Lys Tyr 
    530                 535                 540                 


Glu Gln Ile Glu Glu Gly Thr Val Arg Arg Leu Ile Ile His Arg Leu 
545                 550                 555                 560 


Lys Ala Asp Asp Asp Gly Ile Tyr Leu Cys Glu Met Arg Gly Arg Val 
                565                 570                 575     


Arg Thr Val Ala Asn Val Thr Val Lys Gly Pro Ile Leu Lys Arg Leu 
            580                 585                 590         


Pro Arg Lys Leu Asp Val Leu Glu Gly Glu Asn Ala Val Leu Leu Val 
        595                 600                 605             


Glu Thr Leu Glu Ala Gly Val Glu Gly Arg Trp Ser Arg Asp Gly Glu 
    610                 615                 620                 


Glu Leu Pro Val Ile Cys Gln Ser Ser Ser Gly His Met His Ala Leu 
625                 630                 635                 640 


Val Leu Pro Gly Val Thr Arg Glu Asp Ala Gly Glu Val Thr Phe Ser 
                645                 650                 655     


Leu Gly Asn Ser Arg Thr Thr Thr Leu Leu Arg Val Lys Cys Val Lys 
            660                 665                 670         


His Ser Pro Pro Gly Pro Pro Ile Leu Ala Glu Met Phe Lys Gly His 
        675                 680                 685             


Lys Asn Thr Val Leu Leu Thr Trp Lys Pro Pro Glu Pro Ala Pro Glu 
    690                 695                 700                 


Thr Pro Phe Ile Tyr Arg Leu Glu Arg Gln Glu Val Gly Ser Glu Asp 
705                 710                 715                 720 


Trp Ile Gln Cys Phe Ser Ile Glu Lys Ala Gly Ala Val Glu Val Pro 
                725                 730                 735     


Gly Asp Cys Val Pro Ser Glu Gly Asp Tyr Arg Phe Arg Ile Cys Thr 
            740                 745                 750         


Val Ser Gly His Gly Arg Ser Pro His Val Val Phe His Gly Ser Ala 
        755                 760                 765             


His Leu Val Pro Thr Ala Arg Leu Val Ala Gly Leu Glu Asp Val Gln 
    770                 775                 780                 


Val Tyr Asp Gly Glu Asp Ala Val Phe Ser Leu Asp Leu Ser Thr Ile 
785                 790                 795                 800 


Ile Gln Gly Thr Trp Phe Leu Asn Gly Glu Glu Leu Lys Ser Asn Glu 
                805                 810                 815     


Pro Glu Gly Gln Val Glu Pro Gly Ala Leu Arg Tyr Arg Ile Glu Gln 
            820                 825                 830         


Lys Gly Leu Gln His Arg Leu Ile Leu His Ala Val Lys His Gln Asp 
        835                 840                 845             


Ser Gly Ala Leu Val Gly Phe Ser Cys Pro Gly Val Gln Asp Ser Ala 
    850                 855                 860                 


Ala Leu Thr Ile Gln Glu Ser Pro Val His Ile Leu Ser Pro Gln Asp 
865                 870                 875                 880 


Arg Val Ser Leu Thr Phe Thr Thr Ser Glu Arg Val Val Leu Thr Cys 
                885                 890                 895     


Glu Leu Ser Arg Val Asp Phe Pro Ala Thr Trp Tyr Lys Asp Gly Gln 
            900                 905                 910         


Lys Val Glu Glu Ser Glu Leu Leu Val Val Lys Met Asp Gly Arg Lys 
        915                 920                 925             


His Arg Leu Ile Leu Pro Glu Ala Lys Val Gln Asp Ser Gly Glu Phe 
    930                 935                 940                 


Glu Cys Arg Thr Glu Gly Val Ser Ala Phe Phe Gly Val Thr Val Gln 
945                 950                 955                 960 


Asp Pro Pro Val His Ile Val Asp Pro Arg Glu His Val Phe Val His 
                965                 970                 975     


Ala Ile Thr Ser Glu Cys Val Met Leu Ala Cys Glu Val Asp Arg Glu 
            980                 985                 990         


Asp Ala Pro Val Arg Trp Tyr Lys  Asp Gly Gln Glu Val  Glu Glu Ser 
        995                 1000                 1005             


Asp Phe  Val Val Leu Glu Asn  Glu Gly Pro His Arg  Arg Leu Val 
    1010                 1015                 1020             


Leu Pro  Ala Thr Gln Pro Ser  Asp Gly Gly Glu Phe  Gln Cys Val 
    1025                 1030                 1035             


Ala Gly  Asp Glu Cys Ala Tyr  Phe Thr Val Thr Ile  Thr Asp Val 
    1040                 1045                 1050             


Ser Ser  Trp Ile Val Tyr Pro  Ser Gly Lys Val Tyr  Val Ala Ala 
    1055                 1060                 1065             


Val Arg  Leu Glu Arg Val Val  Leu Thr Cys Glu Leu  Cys Arg Pro 
    1070                 1075                 1080             


Trp Ala  Glu Val Arg Trp Thr  Lys Asp Gly Glu Glu  Val Val Glu 
    1085                 1090                 1095             


Ser Pro  Ala Leu Leu Leu Gln  Lys Glu Asp Thr Val  Arg Arg Leu 
    1100                 1105                 1110             


Val Leu  Pro Ala Val Gln Leu  Glu Asp Ser Gly Glu  Tyr Leu Cys 
    1115                 1120                 1125             


Glu Ile  Asp Asp Glu Ser Ala  Ser Phe Thr Val Thr  Val Thr Glu 
    1130                 1135                 1140             


Pro Pro  Val Arg Ile Ile Tyr  Pro Arg Asp Glu Val  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Thr Leu Glu Cys Val  Val Leu Met Cys Glu  Leu Ser Arg 
    1160                 1165                 1170             


Glu Asp  Ala Pro Val Arg Trp  Tyr Lys Asp Gly Leu  Glu Val Glu 
    1175                 1180                 1185             


Glu Ser  Glu Ala Leu Val Leu  Glu Arg Asp Gly Pro  Arg Cys Arg 
    1190                 1195                 1200             


Leu Val  Leu Pro Ala Ala Gln  Pro Glu Asp Gly Gly  Glu Phe Val 
    1205                 1210                 1215             


Cys Asp  Ala Gly Asp Asp Ser  Ala Phe Phe Thr Val  Thr Val Thr 
    1220                 1225                 1230             


Glu Pro  Pro Val Gln Phe Leu  Ala Leu Glu Thr Thr  Pro Ser Pro 
    1235                 1240                 1245             


Leu Cys  Val Ala Pro Gly Glu  Pro Val Val Leu Ser  Cys Glu Leu 
    1250                 1255                 1260             


Ser Arg  Ala Gly Ala Pro Val  Val Trp Ser His Asn  Gly Arg Pro 
    1265                 1270                 1275             


Val Gln  Glu Gly Glu Gly Leu  Glu Leu His Ala Glu  Gly Pro Arg 
    1280                 1285                 1290             


Arg Val  Leu Cys Ile Gln Ala  Ala Gly Pro Ala His  Ala Gly Leu 
    1295                 1300                 1305             


Tyr Thr  Cys Gln Ser Gly Ala  Ala Pro Gly Ala Pro  Ser Leu Ser 
    1310                 1315                 1320             


Phe Thr  Val Gln Val Ala Glu  Pro Pro Val Arg Val  Val Ala Pro 
    1325                 1330                 1335             


Glu Ala  Ala Gln Thr Arg Val  Arg Ser Thr Pro Gly  Gly Asp Leu 
    1340                 1345                 1350             


Glu Leu  Val Val His Leu Ser  Gly Pro Gly Gly Pro  Val Arg Trp 
    1355                 1360                 1365             


Tyr Lys  Asp Gly Glu Arg Leu  Ala Ser Gln Gly Arg  Val Gln Leu 
    1370                 1375                 1380             


Glu Gln  Ala Gly Ala Arg Gln  Val Leu Arg Val Gln  Gly Ala Arg 
    1385                 1390                 1395             


Ser Gly  Asp Ala Gly Glu Tyr  Leu Cys Asp Ala Pro  Gln Asp Ser 
    1400                 1405                 1410             


Arg Ile  Phe Leu Val Ser Val  Glu Glu Pro Leu Leu  Val Lys Leu 
    1415                 1420                 1425             


Val Ser  Glu Leu Thr Pro Leu  Thr Val His Glu Gly  Asp Asp Ala 
    1430                 1435                 1440             


Thr Phe  Arg Cys Glu Val Ser  Pro Pro Asp Ala Asp  Val Thr Trp 
    1445                 1450                 1455             


Leu Arg  Asn Gly Ala Val Val  Thr Pro Gly Pro Gln  Arg Gln Ser 
    1460                 1465                 1470             


Cys Cys  Ser Tyr Gly Gly Cys  Arg Met Cys Gly Gln  Arg Lys Ala 
    1475                 1480                 1485             


Arg Met  Cys Val Ser Lys Trp  Arg Gln Ala Glu Trp  Val Gln Arg 
    1490                 1495                 1500             


Gly Pro  Cys Ala Gly Cys Glu  Val Gly Ser Pro Cys  Pro Thr Thr 
    1505                 1510                 1515             


Leu Ala  Cys Pro Trp Pro Arg  Met Gly Thr Ser Thr  Ala Ser Ser 
    1520                 1525                 1530             


Ser Met  Val Ser Tyr Trp Pro  Thr Arg Ala Pro Thr  Ala Ala Arg 
    1535                 1540                 1545             


Ala Thr  Thr Ile Ala Pro Trp  Pro Gly Ser Ala 
    1550                 1555                 


<210>  217
<211>  1424
<212>  DNA
<213>  Homosapiens

<400>  217
gaaggactgg ggaagactgg atgagaaggg tagaagaggg tgggtgtggg atggggaggg     60

gagagtggaa aggccctggg cagaccctgg cagaaggggc acggggcagg gtgtgagttc    120

cccactagca gggccaggtg agctatggtg ctgcacctac tgctcttctt gctgctgacc    180

ccacagggtg ggcacagctg ccaggggctg gagctggccc gggaacttgt tctggccaag    240

gtgagggccc tgttcttgga tgccttgggg ccccccgcgg tgaccaggga aggtggggac    300

cctggagtca ggcggctgcc ccgaagacat gccctggggg gcttcacaca caggggctct    360

gagcccgagg aagaggagga tgtctcccaa gccatccttt tcccagccac agatgccagc    420

tgtgaggaca agtcagctgc cagagggctg gcccaggagg ctgaggaggg cctcttcaga    480

tacatgttcc ggccatccca gcatacacgc agccgccagg tgacttcagc ccagctgtgg    540

ttccacaccg ggctggacag gcagggcaca gcagcctcca atagctctga gcccctgcta    600

ggcctgctgg cactgtcacc gggaggaccc gtggctgtgc ccatgtcttt gggccatgct    660

ccccctcact gggccgtgct gcacctggcc acctctgctc tctctctgct gacccacccc    720

gtcctggtgc tgctgctgcg ctgtcccctc tgtacctgct cagcccggcc tgaggccacg    780

cccttcctgg tggcccacac tcggaccaga ccacccagtg gaggggagag agcccgacgc    840

tcaactcccc tgatgtcctg gccttggtct ccctctgctc tgcgcctgct gcagaggcct    900

ccggaggaac cggctgccca tgccaactgc cacagagtag cactgaacat ctccttccag    960

gagctgggct gggaacggtg gatcgtgtac cctcccagtt tcatcttcca ctactgtcat   1020

ggtggttgtg ggctgcacat cccaccaaac ctgtcccttc cagtccctgg ggctccccct   1080

accccagccc agccctactc cttgctgcca ggggcccagc cctgctgtgc tgctctccca   1140

gggaccatga ggcccctaca tgtccgcacc acctcggatg gaggttactc tttcaagtat   1200

gagacagtgc ccaaccttct cacgcagcac tgtgcttgta tctaagggtg gggggtcttc   1260

cttcttaatc ccatggctgg tggccacgcc cccaccatca tcagctggga ggaaaggcag   1320

agttgggaaa tagatggctc ccactcctcc ctcctttcac ttctctgcct atgggctacc   1380

ctccccaccc cacttctatc tcaataaaga acacagtgca tatg                    1424


<210>  218
<211>  366
<212>  PRT
<213>  Homosapiens

<400>  218

Met Val Leu His Leu Leu Leu Phe Leu Leu Leu Thr Pro Gln Gly Gly 
1               5                   10                  15      


His Ser Cys Gln Gly Leu Glu Leu Ala Arg Glu Leu Val Leu Ala Lys 
            20                  25                  30          


Val Arg Ala Leu Phe Leu Asp Ala Leu Gly Pro Pro Ala Val Thr Arg 
        35                  40                  45              


Glu Gly Gly Asp Pro Gly Val Arg Arg Leu Pro Arg Arg His Ala Leu 
    50                  55                  60                  


Gly Gly Phe Thr His Arg Gly Ser Glu Pro Glu Glu Glu Glu Asp Val 
65                  70                  75                  80  


Ser Gln Ala Ile Leu Phe Pro Ala Thr Asp Ala Ser Cys Glu Asp Lys 
                85                  90                  95      


Ser Ala Ala Arg Gly Leu Ala Gln Glu Ala Glu Glu Gly Leu Phe Arg 
            100                 105                 110         


Tyr Met Phe Arg Pro Ser Gln His Thr Arg Ser Arg Gln Val Thr Ser 
        115                 120                 125             


Ala Gln Leu Trp Phe His Thr Gly Leu Asp Arg Gln Gly Thr Ala Ala 
    130                 135                 140                 


Ser Asn Ser Ser Glu Pro Leu Leu Gly Leu Leu Ala Leu Ser Pro Gly 
145                 150                 155                 160 


Gly Pro Val Ala Val Pro Met Ser Leu Gly His Ala Pro Pro His Trp 
                165                 170                 175     


Ala Val Leu His Leu Ala Thr Ser Ala Leu Ser Leu Leu Thr His Pro 
            180                 185                 190         


Val Leu Val Leu Leu Leu Arg Cys Pro Leu Cys Thr Cys Ser Ala Arg 
        195                 200                 205             


Pro Glu Ala Thr Pro Phe Leu Val Ala His Thr Arg Thr Arg Pro Pro 
    210                 215                 220                 


Ser Gly Gly Glu Arg Ala Arg Arg Ser Thr Pro Leu Met Ser Trp Pro 
225                 230                 235                 240 


Trp Ser Pro Ser Ala Leu Arg Leu Leu Gln Arg Pro Pro Glu Glu Pro 
                245                 250                 255     


Ala Ala His Ala Asn Cys His Arg Val Ala Leu Asn Ile Ser Phe Gln 
            260                 265                 270         


Glu Leu Gly Trp Glu Arg Trp Ile Val Tyr Pro Pro Ser Phe Ile Phe 
        275                 280                 285             


His Tyr Cys His Gly Gly Cys Gly Leu His Ile Pro Pro Asn Leu Ser 
    290                 295                 300                 


Leu Pro Val Pro Gly Ala Pro Pro Thr Pro Ala Gln Pro Tyr Ser Leu 
305                 310                 315                 320 


Leu Pro Gly Ala Gln Pro Cys Cys Ala Ala Leu Pro Gly Thr Met Arg 
                325                 330                 335     


Pro Leu His Val Arg Thr Thr Ser Asp Gly Gly Tyr Ser Phe Lys Tyr 
            340                 345                 350         


Glu Thr Val Pro Asn Leu Leu Thr Gln His Cys Ala Cys Ile 
        355                 360                 365     


<210>  219
<211>  3623
<212>  DNA
<213>  Homosapiens

<400>  219
gataggcgcc gggcagctga gctggtagga ggaccagacg gggatgttcg gctccgcccc     60

ccagcgtccc gtggccatga cgaccgctca gagggactcc ctgttgtgga agctcgcggg    120

gttgctgcgg gagtccgggg atgtggtcct gtctggctgt agcaccctga gcctgctgac    180

tcccacactg caacagctga accacgtatt tgagctgcac ctggggccat ggggccctgg    240

ccagacaggc tttgtggctc tgccctccca tcctgccgac tcccctgtta ttcttcagct    300

tcagtttctc ttcgatgtgc tgcagaaaac actttcactc aagctggtcc atgttgctgg    360

tcctggcccc acagggccca tcaagatttt ccccttcaaa tcccttcggc acctggagct    420

ccgaggtgtt cccctccact gtctgcatgg cctccgaggc atctactccc agctggagac    480

cctgatttgc agcaggagcc tccaggcatt agaggagctc ctctcagcct gcggcggcga    540

cttctgctct gccctccctt ggctggctct gctttctgcc aacttcagct acaatgcact    600

gaccgcctta gacagctccc tgcgcctctt gtcagctctg cgtttcttga acctaagcca    660

caatcaagtc caggactgtc agggattcct gatggatttg tgtgagctcc accatctgga    720

catctcctat aatcgcctgc atttggtgcc aagaatggga ccctcagggg ctgctctggg    780

ggtcctgata ctgcgaggca atgagcttcg gagcctgcat ggcctagagc agctgaggaa    840

tctgcggcac ctggatttgg catacaacct gctggaagga caccgggagc tgtcaccact    900

gtggctgctg gctgagctcc gcaagctcta cctggagggg aaccctcttt ggttccaccc    960

tgagcaccga gcagccactg cccagtactt gtcaccccgg gccagggatg ctgctactgg   1020

cttccttctc gatggcaagg tcttgtcact gacagatttt cagactcaca catccttggg   1080

gctcagcccc atgggcccac ctttgccctg gccagtgggg agtactcctg aaacctcagg   1140

tggccctgac ctgagtgaca gcctctcctc agggggtgtt gtgacccagc ccctgcttca   1200

taaggttaag agccgagtcc atgtgaggcg ggcaagcatc tctgaaccca gtgatacgga   1260

cccggagccc ggaactctga acccctctcc ggctggatgg ttcgtgcagc agcacccgga   1320

gctggagctc atgagcagct tccgggaacg gttcggccgc aactggctgc agtacaggag   1380

tcacctggag ccctccggaa accctctgcc ggccaccccc actacttctg cacccagtgc   1440

acctccagcc agctcccagg gccccgacac tgcacccaga ccttcacccc cgcaggagga   1500

agccagaggc ccccaggagt caccacagaa aatgtcagag gaggtcaggg cagagccaca   1560

ggaggaggaa gaggagaagg aggggaagga ggagaaggag gagggggaga tggtggaaca   1620

gggagaagag gaggcaggag aggaggaaga agaggagcag gaccagaagg aagtggaagc   1680

ggaactctgt cgccccttgt tggtgtgtcc cctggagggg cctgagggca tacggggcag   1740

ggaatgcttt ctcagggtca cttctgccca cctgtttgag gtggaactcc aagcagctcg   1800

caccttggag cgactggagc tccagagtct ggaggcagct gagatagagc cggaggccca   1860

ggcccagagg tcgcccaggc ccacgggctc agatctgctc cctggagccc ccatcctcag   1920

tctgcgcttc tcctacatct gccctgaccg gcagttgcgt cgctatttgg tgctggagcc   1980

tgatgcccac gcagctgtcc aggagctgct tgccgtgttg accccagtca ccaatgtggc   2040

tcgggaacag cttggggagg ccagggacct cctgctgggt agattccagt gtctacgctg   2100

tggccatgag ttcaagccag aggagcccag gatgggatta gacagtgagg aaggctggag   2160

gcctctgttc caaaagacag aatctcctgc tgtgtgtcct aactgtggta gtgaccacgt   2220

ggttctcctc gctgtgtctc ggggaacccc caacagggag cggaaacagg gagagcagtc   2280

tctggctcct tctccgtttg ccagccctgt ctgccaccct cctggccatg gtgaccacct   2340

tgacagggcc aagaacagcc cacctcaggc accgagcacc cgtgaccatg gtagttggag   2400

cctcagtccc ccccctgagc gctgtggcct ccgctctgtg gaccaccgac tccggctctt   2460

cctggatgtt gaggtgttca gcgatgccca ggaggagttc cagtgctgcc tcaaggtgcc   2520

agtggcattg gcaggccaca ctggggagtt catgtgcctt gtggttgtgt ctgaccgcag   2580

gctgtacctg ttgaaggtga ctggggagat gcgtgagcct ccagctagct ggctgcagct   2640

gaccctggct gttcccctgc aggatctgag tggcatagag ctgggcctgg caggccagag   2700

cctgcggcta gagtgggcag ctggggcggg ccgctgtgtg ctgctgcccc gagatgccag   2760

gcattgccgg gccttcctag aggagctcct tgatgtcttg cagtctctgc cccctgcctg   2820

gaggaactgt gtcagtgcca cagaggagga ggtcaccccc cagcaccggc tctggccatt   2880

gctggaaaaa gactcatcct tggaggctcg ccagttcttc taccttcggg cgttcctggt   2940

tgaaggccct tccacctgcc tcgtatccct gttgctgact ccgtccaccc tgttcctgtt   3000

agatgaggat gctgcagggt ccccggcaga gccctctcct ccagcagcat ctggcgaagc   3060

ctctgagaag gtgcctccct cggggccggg ccctgctgtg cgtgtcaggg agcagcagcc   3120

actcagcagc ctgagctccg tgctgctcta ccgctcagcc cctgaggact tgcggctgct   3180

cttctacgat gaggtgtccc ggctggagag cttttgggca ctccgtgtgg tgtgtcagga   3240

gcagctgaca gccctgcttg cctggatccg ggaaccatgg gaggagctgt tttccgtcgg   3300

actccggaca gtgatccaag aggcgctggc ccttgaccga tgagggtccc acgctgacct   3360

tggccctgac ctcaggagcc acgctgtaga cattccctct cctggtctct gggtctggct   3420

tccaggctct ggctgtggat gtcttcagcc tctgggtgct ggccagtgag gtcccaaatg   3480

acccagggct taagggagag gcgagagaat gatctggcct caggggacag gccacctggt   3540

caggaggaat atttttcctg cactttttct caggtatcaa taaagttgtt tccaactcat   3600

aaaaaagaaa aaaaaaaaaa aaa                                           3623


<210>  220
<211>  1099
<212>  PRT
<213>  Homosapiens

<400>  220

Met Phe Gly Ser Ala Pro Gln Arg Pro Val Ala Met Thr Thr Ala Gln 
1               5                   10                  15      


Arg Asp Ser Leu Leu Trp Lys Leu Ala Gly Leu Leu Arg Glu Ser Gly 
            20                  25                  30          


Asp Val Val Leu Ser Gly Cys Ser Thr Leu Ser Leu Leu Thr Pro Thr 
        35                  40                  45              


Leu Gln Gln Leu Asn His Val Phe Glu Leu His Leu Gly Pro Trp Gly 
    50                  55                  60                  


Pro Gly Gln Thr Gly Phe Val Ala Leu Pro Ser His Pro Ala Asp Ser 
65                  70                  75                  80  


Pro Val Ile Leu Gln Leu Gln Phe Leu Phe Asp Val Leu Gln Lys Thr 
                85                  90                  95      


Leu Ser Leu Lys Leu Val His Val Ala Gly Pro Gly Pro Thr Gly Pro 
            100                 105                 110         


Ile Lys Ile Phe Pro Phe Lys Ser Leu Arg His Leu Glu Leu Arg Gly 
        115                 120                 125             


Val Pro Leu His Cys Leu His Gly Leu Arg Gly Ile Tyr Ser Gln Leu 
    130                 135                 140                 


Glu Thr Leu Ile Cys Ser Arg Ser Leu Gln Ala Leu Glu Glu Leu Leu 
145                 150                 155                 160 


Ser Ala Cys Gly Gly Asp Phe Cys Ser Ala Leu Pro Trp Leu Ala Leu 
                165                 170                 175     


Leu Ser Ala Asn Phe Ser Tyr Asn Ala Leu Thr Ala Leu Asp Ser Ser 
            180                 185                 190         


Leu Arg Leu Leu Ser Ala Leu Arg Phe Leu Asn Leu Ser His Asn Gln 
        195                 200                 205             


Val Gln Asp Cys Gln Gly Phe Leu Met Asp Leu Cys Glu Leu His His 
    210                 215                 220                 


Leu Asp Ile Ser Tyr Asn Arg Leu His Leu Val Pro Arg Met Gly Pro 
225                 230                 235                 240 


Ser Gly Ala Ala Leu Gly Val Leu Ile Leu Arg Gly Asn Glu Leu Arg 
                245                 250                 255     


Ser Leu His Gly Leu Glu Gln Leu Arg Asn Leu Arg His Leu Asp Leu 
            260                 265                 270         


Ala Tyr Asn Leu Leu Glu Gly His Arg Glu Leu Ser Pro Leu Trp Leu 
        275                 280                 285             


Leu Ala Glu Leu Arg Lys Leu Tyr Leu Glu Gly Asn Pro Leu Trp Phe 
    290                 295                 300                 


His Pro Glu His Arg Ala Ala Thr Ala Gln Tyr Leu Ser Pro Arg Ala 
305                 310                 315                 320 


Arg Asp Ala Ala Thr Gly Phe Leu Leu Asp Gly Lys Val Leu Ser Leu 
                325                 330                 335     


Thr Asp Phe Gln Thr His Thr Ser Leu Gly Leu Ser Pro Met Gly Pro 
            340                 345                 350         


Pro Leu Pro Trp Pro Val Gly Ser Thr Pro Glu Thr Ser Gly Gly Pro 
        355                 360                 365             


Asp Leu Ser Asp Ser Leu Ser Ser Gly Gly Val Val Thr Gln Pro Leu 
    370                 375                 380                 


Leu His Lys Val Lys Ser Arg Val His Val Arg Arg Ala Ser Ile Ser 
385                 390                 395                 400 


Glu Pro Ser Asp Thr Asp Pro Glu Pro Gly Thr Leu Asn Pro Ser Pro 
                405                 410                 415     


Ala Gly Trp Phe Val Gln Gln His Pro Glu Leu Glu Leu Met Ser Ser 
            420                 425                 430         


Phe Arg Glu Arg Phe Gly Arg Asn Trp Leu Gln Tyr Arg Ser His Leu 
        435                 440                 445             


Glu Pro Ser Gly Asn Pro Leu Pro Ala Thr Pro Thr Thr Ser Ala Pro 
    450                 455                 460                 


Ser Ala Pro Pro Ala Ser Ser Gln Gly Pro Asp Thr Ala Pro Arg Pro 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Glu Ala Arg Gly Pro Gln Glu Ser Pro Gln Lys 
                485                 490                 495     


Met Ser Glu Glu Val Arg Ala Glu Pro Gln Glu Glu Glu Glu Glu Lys 
            500                 505                 510         


Glu Gly Lys Glu Glu Lys Glu Glu Gly Glu Met Val Glu Gln Gly Glu 
        515                 520                 525             


Glu Glu Ala Gly Glu Glu Glu Glu Glu Glu Gln Asp Gln Lys Glu Val 
    530                 535                 540                 


Glu Ala Glu Leu Cys Arg Pro Leu Leu Val Cys Pro Leu Glu Gly Pro 
545                 550                 555                 560 


Glu Gly Ile Arg Gly Arg Glu Cys Phe Leu Arg Val Thr Ser Ala His 
                565                 570                 575     


Leu Phe Glu Val Glu Leu Gln Ala Ala Arg Thr Leu Glu Arg Leu Glu 
            580                 585                 590         


Leu Gln Ser Leu Glu Ala Ala Glu Ile Glu Pro Glu Ala Gln Ala Gln 
        595                 600                 605             


Arg Ser Pro Arg Pro Thr Gly Ser Asp Leu Leu Pro Gly Ala Pro Ile 
    610                 615                 620                 


Leu Ser Leu Arg Phe Ser Tyr Ile Cys Pro Asp Arg Gln Leu Arg Arg 
625                 630                 635                 640 


Tyr Leu Val Leu Glu Pro Asp Ala His Ala Ala Val Gln Glu Leu Leu 
                645                 650                 655     


Ala Val Leu Thr Pro Val Thr Asn Val Ala Arg Glu Gln Leu Gly Glu 
            660                 665                 670         


Ala Arg Asp Leu Leu Leu Gly Arg Phe Gln Cys Leu Arg Cys Gly His 
        675                 680                 685             


Glu Phe Lys Pro Glu Glu Pro Arg Met Gly Leu Asp Ser Glu Glu Gly 
    690                 695                 700                 


Trp Arg Pro Leu Phe Gln Lys Thr Glu Ser Pro Ala Val Cys Pro Asn 
705                 710                 715                 720 


Cys Gly Ser Asp His Val Val Leu Leu Ala Val Ser Arg Gly Thr Pro 
                725                 730                 735     


Asn Arg Glu Arg Lys Gln Gly Glu Gln Ser Leu Ala Pro Ser Pro Phe 
            740                 745                 750         


Ala Ser Pro Val Cys His Pro Pro Gly His Gly Asp His Leu Asp Arg 
        755                 760                 765             


Ala Lys Asn Ser Pro Pro Gln Ala Pro Ser Thr Arg Asp His Gly Ser 
    770                 775                 780                 


Trp Ser Leu Ser Pro Pro Pro Glu Arg Cys Gly Leu Arg Ser Val Asp 
785                 790                 795                 800 


His Arg Leu Arg Leu Phe Leu Asp Val Glu Val Phe Ser Asp Ala Gln 
                805                 810                 815     


Glu Glu Phe Gln Cys Cys Leu Lys Val Pro Val Ala Leu Ala Gly His 
            820                 825                 830         


Thr Gly Glu Phe Met Cys Leu Val Val Val Ser Asp Arg Arg Leu Tyr 
        835                 840                 845             


Leu Leu Lys Val Thr Gly Glu Met Arg Glu Pro Pro Ala Ser Trp Leu 
    850                 855                 860                 


Gln Leu Thr Leu Ala Val Pro Leu Gln Asp Leu Ser Gly Ile Glu Leu 
865                 870                 875                 880 


Gly Leu Ala Gly Gln Ser Leu Arg Leu Glu Trp Ala Ala Gly Ala Gly 
                885                 890                 895     


Arg Cys Val Leu Leu Pro Arg Asp Ala Arg His Cys Arg Ala Phe Leu 
            900                 905                 910         


Glu Glu Leu Leu Asp Val Leu Gln Ser Leu Pro Pro Ala Trp Arg Asn 
        915                 920                 925             


Cys Val Ser Ala Thr Glu Glu Glu Val Thr Pro Gln His Arg Leu Trp 
    930                 935                 940                 


Pro Leu Leu Glu Lys Asp Ser Ser Leu Glu Ala Arg Gln Phe Phe Tyr 
945                 950                 955                 960 


Leu Arg Ala Phe Leu Val Glu Gly Pro Ser Thr Cys Leu Val Ser Leu 
                965                 970                 975     


Leu Leu Thr Pro Ser Thr Leu Phe Leu Leu Asp Glu Asp Ala Ala Gly 
            980                 985                 990         


Ser Pro Ala Glu Pro Ser Pro Pro  Ala Ala Ser Gly Glu  Ala Ser Glu 
        995                 1000                 1005             


Lys Val  Pro Pro Ser Gly Pro  Gly Pro Ala Val Arg  Val Arg Glu 
    1010                 1015                 1020             


Gln Gln  Pro Leu Ser Ser Leu  Ser Ser Val Leu Leu  Tyr Arg Ser 
    1025                 1030                 1035             


Ala Pro  Glu Asp Leu Arg Leu  Leu Phe Tyr Asp Glu  Val Ser Arg 
    1040                 1045                 1050             


Leu Glu  Ser Phe Trp Ala Leu  Arg Val Val Cys Gln  Glu Gln Leu 
    1055                 1060                 1065             


Thr Ala  Leu Leu Ala Trp Ile  Arg Glu Pro Trp Glu  Glu Leu Phe 
    1070                 1075                 1080             


Ser Val  Gly Leu Arg Thr Val  Ile Gln Glu Ala Leu  Ala Leu Asp 
    1085                 1090                 1095             


Arg 
    


<210>  221
<211>  4257
<212>  DNA
<213>  Homosapiens

<400>  221
agcgggcggg gcggagcgcg aggaggtgga gccgcgggct gcgggctccg gcgcctgcgt     60

ccgcccggcc agcccggctc tgcgctgcga gaggccggac ggcagtcgcg gctgcgctcg    120

ggagagagcg cgggggacat ggggcgcggc ggcccgcctg ggcctcgcag gctccggagc    180

cccgagtgag cgagagcgtc cccagccgcc tacctggcca tggccaacgg agtgatcccg    240

ccgcccgggg gcgcctcccc cctaccccag gtccgggtgc ccttggagga gccccctcta    300

agtccagacg tggaggagga ggacgatgac ttgggcaaga ccttggctgt gagcaggttt    360

ggggacctca tcagcaagcc cccggcctgg gaccccgaga agcccagccg cagctacagc    420

gagcgggact ttgagtttca ccggcacaca tcccaccaca cccaccaccc gctctcagcg    480

cgcctgcctc caccccacaa gctgcggcgg ctgcccccca cctctgcccg gcacaccagg    540

agaaagagga agaaggagaa aacctctgct cctccctccg aggggacccc tcccatccag    600

gaggaggggg gagctggagt ggatgaggaa gaggaggaag aggaggaaga ggaaggagaa    660

tctgaggcag aacctgtgga gccccccccc tcagggaccc cacagaaggc aaagttctcc    720

attggaagtg acgaggatga cagtccaggc ctccctggga gggctgctgt caccaagccc    780

ctgccctcgg tgggcccaca cactgacaag agcccccagc actccagcag gccgtgctct    840

gagctgaggg acggtgatgg aaccaccgac ctggccctgt caagtccaag gctgctgtgt    900

tgcctcccca gctcccccag cccccgggcc cgggcctccc gactcgctgg ggagaaaagc    960

cggccctgga gcccatcggc cagttatgac ctgcgggagc gactgtgccc aggcagtgcc   1020

ctgggcaacc caggtggtcc agagcagcag gtgcccacag atgaggcgga ggcccagatg   1080

ctgggttctg cagacctgga cgacatgaag agtcaccgac tggaggacaa ccctggtgtg   1140

cggcgacact tagtgaaaaa gccctcccgg acgcagggcg ggaggggcag tcccagcggc   1200

ctggccccca tccttcgcag gaagaagaag aagaaaaagc tggaccggag gcctcatgag   1260

gtgttcgtgg agctgaacga gctgatgctg gaccgcagcc aggagcccca ctggcgggag   1320

acggcccgct ggatcaagtt tgaggaggac gtggaggagg agacggagcg ctgggggaag   1380

ccccatgttg cctcgctctc cttccgtagc cttctggagc tcaggaggac catcgcccat   1440

ggagctgccc tcctggacct ggagcaaacc accctgccag gcattgcaca cctcgtggtg   1500

gagaccatga ttgtgtctga ccagatccgg ccggaggaca gggccagcgt cctacgtacc   1560

ctgctactga agcacagcca tcccaacgat gacaaggaca gtggcttctt tccccgaaac   1620

ccatcgagct ccagcatgaa ctcggttctg gggaatcatc acccaactcc cagccatggc   1680

cctgatgggg cggtgcctac catggctgat gacctggggg agccagcccc actctggcca   1740

catgaccctg acgccaagga gaagcccctc cacatgcctg ggggagatgg tcaccggggg   1800

aaaagcctga agctgctgga gaagatccct gaagatgctg aggccacggt tgtgcttgtg   1860

ggttgtgtgc ctttcttgga gcagcctgca gcagccttcg tgcgtctgaa tgaggctgta   1920

ctcctggagt ctgtgcttga ggtccctgtc ccggtccgct tcctcttcgt gatgctgggg   1980

cccagccaca ccagcactga ctatcacgag cttgggcgct ccattgccac ccttatgtct   2040

gacaagctgt ttcatgaggc tgcctacaag gcagatgacc ggcaagacct cctaagtgcc   2100

atcagcgagt tcctggatgg cagcattgtg atccccccgt ccgaggtgga gggccgtgac   2160

ctgctgcgct ccgtggctgc tttccagcga gagctgctta ggaagcggcg agagcgtgaa   2220

cagaccaaag tcgagatgac cacacggggt ggctacacgg cccctgggaa agaactgtct   2280

ttggagttgg ggggctctga ggcgacccct gaagatgacc ccttgctgcg gacgggctcg   2340

gtatttgggg ggcttgtgcg ggatgtgagg cgccggtacc cgcactaccc cagtgacctg   2400

cgagatgcgc tgcactccca gtgtgtggcc gctgtgctct tcatctactt cgcagccctc   2460

agccctgcca tcaccttcgg ggggctgctg ggagagaaga ccgaggggct gatgggcgtg   2520

tccgagctga tcgtgtccac cgctgtgctc ggcgtcctct tctctctgct gggagctcag   2580

ccgctgcttg tggttggctt ctctgggccg ctgcttgtgt ttgaggaagc cttcttcaag   2640

ttctgccgag cccaggacct ggagtacctc actggccggg tgtgggttgg tctctggctg   2700

gtggtcttcg tccttgccct ggtggccgcc gaaggcagct tcctggtccg ctacatctcg   2760

cctttcaccc aggagatctt tgcctttctc atctcactca ttttcatcta cgagaccttc   2820

tacaagctct acaaggtgtt cacagagcgc ccactgctgc cgttctaccc ccctgagggg   2880

gccctggagg ggtccctgga tgctggtctg gagccaaatg gcagtgccct gccccccacc   2940

gagggccccc ccagcccgag gaaccagccc aatacggcac tgctctcact catcctcatg   3000

ctcgggacct tcttcatagc cttcttcctg cgcaagttca ggaacagccg cttcctgggg   3060

ggcaaggctc gtcgcatcat cggggacttt ggcatcccca tctccatcct ggtgatggtc   3120

ctggtggatt actccatcac agacacctac acgcagaagc tgacagtgcc tacagggctc   3180

tcagtgacct ctcccgataa gcgctcgtgg ttcatcccac ccctgggcag tgcccgtcct   3240

ttcccgccgt ggatgatggt ggcagccgct gttcccgccc tcctcgtcct catcctgatc   3300

ttcatggaga cacagatcac ggcgcttata gtcagccaga aggcgcggag gctgctcaag   3360

ggctccggtt tccacctgga cctgctcctc attggctccc tgggggggct ctgtgggctg   3420

tttgggttgc cctggctcac ggctgccacg gtccgctcca tcacccatgt caatgcgttg   3480

acagtgatgc gtactgccat cgcgcctggt gacaagcccc agatccagga ggtgcgggag   3540

cagcgggtca ctggtgtgct catcgccagc ctcgtgggcc tgtccatcgt catgggggct   3600

gtgctgcgtc ggatcccatt ggctgtgctc tttgggatct tcctgtacat gggggtcacg   3660

tccctgtctg gtatccagct gtcccagcgt ttgttgctca tcctcatgcc ggcaaaacac   3720

catcctgagc agccctatgt gaccaaggtg aagacgtggc ggatgcatct gttcacctgc   3780

atccagctgg gctgcatcgc actgctctgg gtggtcaagt ccacggcggc ctcactcgcc   3840

tttcccttcc tgctgctgct cacggtgcct ctgaggcatt gccttctgcc ccggctcttc   3900

caggacaggg agctgcaggc gctggactcg gaagatgctg aaccaaactt cgatgaggat   3960

ggccaggatg agtacaatga gctgcacatg ccagtgtgac ccttgaagac agtgcccctc   4020

agagacccca agaccttagg gattgacacc tgggcctcag gcagagccca accctgggct   4080

ggggggctcc tcaggaccca gagatgtgcc tggaaccact cctgatgcca tggctagagt   4140

ggcccccctg acttctgccc ggggtgttga cctcgcctca cctttcacag accagaccgg   4200

cacaggcttt gagctcatta taaccacact ccttgtctcg taaaaaaaaa aaaaaaa      4257


<210>  222
<211>  1259
<212>  PRT
<213>  Homosapiens

<400>  222

Met Ala Asn Gly Val Ile Pro Pro Pro Gly Gly Ala Ser Pro Leu Pro 
1               5                   10                  15      


Gln Val Arg Val Pro Leu Glu Glu Pro Pro Leu Ser Pro Asp Val Glu 
            20                  25                  30          


Glu Glu Asp Asp Asp Leu Gly Lys Thr Leu Ala Val Ser Arg Phe Gly 
        35                  40                  45              


Asp Leu Ile Ser Lys Pro Pro Ala Trp Asp Pro Glu Lys Pro Ser Arg 
    50                  55                  60                  


Ser Tyr Ser Glu Arg Asp Phe Glu Phe His Arg His Thr Ser His His 
65                  70                  75                  80  


Thr His His Pro Leu Ser Ala Arg Leu Pro Pro Pro His Lys Leu Arg 
                85                  90                  95      


Arg Leu Pro Pro Thr Ser Ala Arg His Thr Arg Arg Lys Arg Lys Lys 
            100                 105                 110         


Glu Lys Thr Ser Ala Pro Pro Ser Glu Gly Thr Pro Pro Ile Gln Glu 
        115                 120                 125             


Glu Gly Gly Ala Gly Val Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Gly Glu Ser Glu Ala Glu Pro Val Glu Pro Pro Pro Ser Gly Thr 
145                 150                 155                 160 


Pro Gln Lys Ala Lys Phe Ser Ile Gly Ser Asp Glu Asp Asp Ser Pro 
                165                 170                 175     


Gly Leu Pro Gly Arg Ala Ala Val Thr Lys Pro Leu Pro Ser Val Gly 
            180                 185                 190         


Pro His Thr Asp Lys Ser Pro Gln His Ser Ser Arg Pro Cys Ser Glu 
        195                 200                 205             


Leu Arg Asp Gly Asp Gly Thr Thr Asp Leu Ala Leu Ser Ser Pro Arg 
    210                 215                 220                 


Leu Leu Cys Cys Leu Pro Ser Ser Pro Ser Pro Arg Ala Arg Ala Ser 
225                 230                 235                 240 


Arg Leu Ala Gly Glu Lys Ser Arg Pro Trp Ser Pro Ser Ala Ser Tyr 
                245                 250                 255     


Asp Leu Arg Glu Arg Leu Cys Pro Gly Ser Ala Leu Gly Asn Pro Gly 
            260                 265                 270         


Gly Pro Glu Gln Gln Val Pro Thr Asp Glu Ala Glu Ala Gln Met Leu 
        275                 280                 285             


Gly Ser Ala Asp Leu Asp Asp Met Lys Ser His Arg Leu Glu Asp Asn 
    290                 295                 300                 


Pro Gly Val Arg Arg His Leu Val Lys Lys Pro Ser Arg Thr Gln Gly 
305                 310                 315                 320 


Gly Arg Gly Ser Pro Ser Gly Leu Ala Pro Ile Leu Arg Arg Lys Lys 
                325                 330                 335     


Lys Lys Lys Lys Leu Asp Arg Arg Pro His Glu Val Phe Val Glu Leu 
            340                 345                 350         


Asn Glu Leu Met Leu Asp Arg Ser Gln Glu Pro His Trp Arg Glu Thr 
        355                 360                 365             


Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu Glu Glu Thr Glu Arg 
    370                 375                 380                 


Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe Arg Ser Leu Leu Glu 
385                 390                 395                 400 


Leu Arg Arg Thr Ile Ala His Gly Ala Ala Leu Leu Asp Leu Glu Gln 
                405                 410                 415     


Thr Thr Leu Pro Gly Ile Ala His Leu Val Val Glu Thr Met Ile Val 
            420                 425                 430         


Ser Asp Gln Ile Arg Pro Glu Asp Arg Ala Ser Val Leu Arg Thr Leu 
        435                 440                 445             


Leu Leu Lys His Ser His Pro Asn Asp Asp Lys Asp Ser Gly Phe Phe 
    450                 455                 460                 


Pro Arg Asn Pro Ser Ser Ser Ser Met Asn Ser Val Leu Gly Asn His 
465                 470                 475                 480 


His Pro Thr Pro Ser His Gly Pro Asp Gly Ala Val Pro Thr Met Ala 
                485                 490                 495     


Asp Asp Leu Gly Glu Pro Ala Pro Leu Trp Pro His Asp Pro Asp Ala 
            500                 505                 510         


Lys Glu Lys Pro Leu His Met Pro Gly Gly Asp Gly His Arg Gly Lys 
        515                 520                 525             


Ser Leu Lys Leu Leu Glu Lys Ile Pro Glu Asp Ala Glu Ala Thr Val 
    530                 535                 540                 


Val Leu Val Gly Cys Val Pro Phe Leu Glu Gln Pro Ala Ala Ala Phe 
545                 550                 555                 560 


Val Arg Leu Asn Glu Ala Val Leu Leu Glu Ser Val Leu Glu Val Pro 
                565                 570                 575     


Val Pro Val Arg Phe Leu Phe Val Met Leu Gly Pro Ser His Thr Ser 
            580                 585                 590         


Thr Asp Tyr His Glu Leu Gly Arg Ser Ile Ala Thr Leu Met Ser Asp 
        595                 600                 605             


Lys Leu Phe His Glu Ala Ala Tyr Lys Ala Asp Asp Arg Gln Asp Leu 
    610                 615                 620                 


Leu Ser Ala Ile Ser Glu Phe Leu Asp Gly Ser Ile Val Ile Pro Pro 
625                 630                 635                 640 


Ser Glu Val Glu Gly Arg Asp Leu Leu Arg Ser Val Ala Ala Phe Gln 
                645                 650                 655     


Arg Glu Leu Leu Arg Lys Arg Arg Glu Arg Glu Gln Thr Lys Val Glu 
            660                 665                 670         


Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Gly Lys Glu Leu Ser Leu 
        675                 680                 685             


Glu Leu Gly Gly Ser Glu Ala Thr Pro Glu Asp Asp Pro Leu Leu Arg 
    690                 695                 700                 


Thr Gly Ser Val Phe Gly Gly Leu Val Arg Asp Val Arg Arg Arg Tyr 
705                 710                 715                 720 


Pro His Tyr Pro Ser Asp Leu Arg Asp Ala Leu His Ser Gln Cys Val 
                725                 730                 735     


Ala Ala Val Leu Phe Ile Tyr Phe Ala Ala Leu Ser Pro Ala Ile Thr 
            740                 745                 750         


Phe Gly Gly Leu Leu Gly Glu Lys Thr Glu Gly Leu Met Gly Val Ser 
        755                 760                 765             


Glu Leu Ile Val Ser Thr Ala Val Leu Gly Val Leu Phe Ser Leu Leu 
    770                 775                 780                 


Gly Ala Gln Pro Leu Leu Val Val Gly Phe Ser Gly Pro Leu Leu Val 
785                 790                 795                 800 


Phe Glu Glu Ala Phe Phe Lys Phe Cys Arg Ala Gln Asp Leu Glu Tyr 
                805                 810                 815     


Leu Thr Gly Arg Val Trp Val Gly Leu Trp Leu Val Val Phe Val Leu 
            820                 825                 830         


Ala Leu Val Ala Ala Glu Gly Ser Phe Leu Val Arg Tyr Ile Ser Pro 
        835                 840                 845             


Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser Leu Ile Phe Ile Tyr 
    850                 855                 860                 


Glu Thr Phe Tyr Lys Leu Tyr Lys Val Phe Thr Glu Arg Pro Leu Leu 
865                 870                 875                 880 


Pro Phe Tyr Pro Pro Glu Gly Ala Leu Glu Gly Ser Leu Asp Ala Gly 
                885                 890                 895     


Leu Glu Pro Asn Gly Ser Ala Leu Pro Pro Thr Glu Gly Pro Pro Ser 
            900                 905                 910         


Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu Ser Leu Ile Leu Met Leu 
        915                 920                 925             


Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg Lys Phe Arg Asn Ser Arg 
    930                 935                 940                 


Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile Gly Asp Phe Gly Ile Pro 
945                 950                 955                 960 


Ile Ser Ile Leu Val Met Val Leu Val Asp Tyr Ser Ile Thr Asp Thr 
                965                 970                 975     


Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly Leu Ser Val Thr Ser Pro 
            980                 985                 990         


Asp Lys Arg Ser Trp Phe Ile Pro  Pro Leu Gly Ser Ala  Arg Pro Phe 
        995                 1000                 1005             


Pro Pro  Trp Met Met Val Ala  Ala Ala Val Pro Ala  Leu Leu Val 
    1010                 1015                 1020             


Leu Ile  Leu Ile Phe Met Glu  Thr Gln Ile Thr Ala  Leu Ile Val 
    1025                 1030                 1035             


Ser Gln  Lys Ala Arg Arg Leu  Leu Lys Gly Ser Gly  Phe His Leu 
    1040                 1045                 1050             


Asp Leu  Leu Leu Ile Gly Ser  Leu Gly Gly Leu Cys  Gly Leu Phe 
    1055                 1060                 1065             


Gly Leu  Pro Trp Leu Thr Ala  Ala Thr Val Arg Ser  Ile Thr His 
    1070                 1075                 1080             


Val Asn  Ala Leu Thr Val Met  Arg Thr Ala Ile Ala  Pro Gly Asp 
    1085                 1090                 1095             


Lys Pro  Gln Ile Gln Glu Val  Arg Glu Gln Arg Val  Thr Gly Val 
    1100                 1105                 1110             


Leu Ile  Ala Ser Leu Val Gly  Leu Ser Ile Val Met  Gly Ala Val 
    1115                 1120                 1125             


Leu Arg  Arg Ile Pro Leu Ala  Val Leu Phe Gly Ile  Phe Leu Tyr 
    1130                 1135                 1140             


Met Gly  Val Thr Ser Leu Ser  Gly Ile Gln Leu Ser  Gln Arg Leu 
    1145                 1150                 1155             


Leu Leu  Ile Leu Met Pro Ala  Lys His His Pro Glu  Gln Pro Tyr 
    1160                 1165                 1170             


Val Thr  Lys Val Lys Thr Trp  Arg Met His Leu Phe  Thr Cys Ile 
    1175                 1180                 1185             


Gln Leu  Gly Cys Ile Ala Leu  Leu Trp Val Val Lys  Ser Thr Ala 
    1190                 1195                 1200             


Ala Ser  Leu Ala Phe Pro Phe  Leu Leu Leu Leu Thr  Val Pro Leu 
    1205                 1210                 1215             


Arg His  Cys Leu Leu Pro Arg  Leu Phe Gln Asp Arg  Glu Leu Gln 
    1220                 1225                 1230             


Ala Leu  Asp Ser Glu Asp Ala  Glu Pro Asn Phe Asp  Glu Asp Gly 
    1235                 1240                 1245             


Gln Asp  Glu Tyr Asn Glu Leu  His Met Pro Val 
    1250                 1255                 


<210>  223
<211>  3944
<212>  DNA
<213>  Homosapiens

<400>  223
cctacctggc catggccaac ggagtgatcc cgccgcccgg gggcgcctcc cccctacccc     60

aggtccgggt gcccttggag gagccccctc taagtccaga cgtggaggag gaggacgatg    120

acttgggcaa gaccttggct gtgagcaggt ttggggacct catcagcaag cccccggcct    180

gggaccccga gaagcccagc cgcagctaca gcgagcggga ctttgagttt caccggcaca    240

catcccacca cacccaccac ccgctctcag cgcgcctgcc tccaccccac aagctgcggc    300

ggctgccccc cacctctgcc cggcacacca ggagaaagag gaagaaggag aaaacctctg    360

ctcctccctc cgaggggacc cctcccatcc aggaggaggg gggagctgga gtggatgagg    420

aagaggagga agaggaggaa gaggaaggag aatctgaggc agaacctgtg gagccccccc    480

cctcagggac cccacagaag gcaaagttct ccattggaag tgacgaggat gacagtccag    540

gcctccctgg gagggctgct gtcaccaagc ccctgccctc ggtgggccca cacactgaca    600

agagccccca gcactccagc agctccccca gcccccgggc ccgggcctcc cgactcgctg    660

gggagaaaag ccggccctgg agcccatcgg ccagttatga cctgcgggag cgactgtgcc    720

caggcagtgc cctgggcaac ccaggtggtc cagagcagca ggtgcccaca gatgaggcgg    780

aggcccagat gctgggttct gcagacctgg acgacatgaa gagtcaccga ctggaggaca    840

accctggtgt gcggcgacac ttagtgaaaa agccctcccg gacgcagggc gggaggggca    900

gtcccagcgg cctggccccc atccttcgca ggaagaagaa gaagaaaaag ctggaccgga    960

ggcctcatga ggtgttcgtg gagctgaacg agctgatgct ggaccgcagc caggagcccc   1020

actggcggga gacggcccgc tggatcaagt ttgaggagga cgtggaggag gagacggagc   1080

gctgggggaa gccccatgtt gcctcgctct ccttccgtag ccttctggag ctcaggagga   1140

ccatcgccca tggagctgcc ctcctggacc tggagcaaac caccctgcca ggcattgcac   1200

acctcgtggt ggagaccatg attgtgtctg accagatccg gccggaggac agggccagcg   1260

tcctacgtac cctgctactg aagcacagcc atcccaacga tgacaaggac agtggcttct   1320

ttccccgaaa cccatcgagc tccagcatga actcggttct ggggaatcat cacccaactc   1380

ccagccatgg ccctgatggg gcggtgccta ccatggctga tgacctgggg gagccagccc   1440

cactctggcc acatgaccct gacgccaagg agaagcccct ccacatgcct gggggagatg   1500

gtcaccgggg gaaaagcctg aagctgctgg agaagatccc tgaagatgct gaggccacgg   1560

ttgtgcttgt gggttgtgtg cctttcttgg agcagcctgc agcagccttc gtgcgtctga   1620

atgaggctgt actcctggag tctgtgcttg aggtccctgt cccggtccgc ttcctcttcg   1680

tgatgctggg gcccagccac accagcactg actatcacga gcttgggcgc tccattgcca   1740

cccttatgtc tgacaagctg tttcatgagg ctgcctacca ggcagatgac cggcaagacc   1800

tcctaagtgc catcagcgag ttcctggatg gcagcattgt gatccccccg tccgaggtgg   1860

agggccgtga cctgctgcgc tccgtggctg ctttccagcg agagctgctt aggaagcggc   1920

gagagcgtga acagaccaaa gtcgagatga ccacacgggg tggctacacg gcccctggga   1980

aagaactgtc tttggagttg gggggctctg aggcgacccc tgaagatgac cccttgctgc   2040

ggacgggctc ggtatttggg gggcttgtgc gggatgtgag gcgccggtac ccgcactacc   2100

ccagtgacct gcgagatgcg ctgcactccc agtgtgtggc cgctgtgctc ttcatctact   2160

tcgcagccct cagccctgcc atcaccttcg gggggctgct gggagagaag accgaggggc   2220

tgatgggcgt gtccgagctg atcgtgtcca ccgctgtgct cggcgtcctc ttctctctgc   2280

tgggagctca gccgctgctt gtggttggct tctctgggcc gctgcttgtg tttgaggaag   2340

ccttcttcaa gttctgccga gcccaggacc tggaatacct cactggccgg gtgtgggttg   2400

gtctctggct ggtggtcttc gtccttgccc tggtggccgc cgaaggcagc ttcctggtcc   2460

gctacatctc gcctttcacc caggagatct ttgcctttct catctcactc attttcatct   2520

acgagacctt ctacaagctc tacaaggtgt tcacagagca cccactgctg ccgttctacc   2580

cccctgaggg ggccctggag gggtccctgg ctgctggtct ggagccaaat ggcagtgccc   2640

tgccccccac cgagggcccc cccagcccga ggaaccagcc caatacggca ctgctctcac   2700

tcatcctcat gctcgggacc ttcttcatag ccttcttcct gcgcaagttc aggaacagcc   2760

gcttcctggg gggcaaggct cgtcgcatca tcggggactt tggcatcccc atctccatcc   2820

tggtgatggt cctggtggat tactccatca cagacaccta cacgcagaag ctgacagtgc   2880

ctacagggct ctcagtgacc tctcccgata agcgctcgtg gttcatccca cccctgggga   2940

gtgcccgtcc tttcccgccg tggatgatgg tggcagccgc tgttcccgcc ctcctcgtcc   3000

tcatcctgat cttcatggag acacagatca cggcgcttat cgtcagccag aaggcgcgga   3060

ggctgctcaa gggctccggt ttccacctgg acctgctcct cattggctcc ctgggggggc   3120

tctgtgggct gtttgggttg ccctggctca cggctgccac ggtccgctcc gtcacccatg   3180

tcaatgcgtt gacagtgatg cgtactgcca tcgcgcctgg tgacaagccc cagatccagg   3240

aggtgcggga gcagcgggtc actggtgtgc tcatcgccag cctcgtgggc ctgtccatcg   3300

tcatgggggc tgtgctgcgt cggatcccat tggctgtgct ctttgggatc ttcctgtaca   3360

tgggggtcac gtccctgtct ggtatccagc tgtcccagcg tctgttgctc atcctcatgc   3420

cggcaaaaca ccatcctgag cagccctatg tgaccaaggt gaagacgtgg cggatgcatc   3480

tgttcacctg catccagctg ggctgcatcg cactgctctg ggtggtcaag tccacggcgg   3540

cctcactcgc ctttcccttc ctgctgctgc tcacggtgcc tctgaggcat tgccttctgc   3600

cccggctctt ccaggacagg gagctgcagg cgctggactc ggaagatgct gaaccaaact   3660

tcgatgagga tggccaggat gagtacaatg agctgcacat gccagtgtga ccctgaagac   3720

agtgcccctc agagacccca agaccttagg gattgacacc tgggcctcag gcagagccca   3780

gccctgggct ggggggctcc tcaggaccta gagatgtgcc tggaaccact cctgatgcca   3840

tggctagagt ggcccccctg acttctgccc ggggtgttga cctcgcctca cctttcacag   3900

accagaccgg cacaggcttt gagctcatta taaccacact cctg                    3944


<210>  224
<211>  1232
<212>  PRT
<213>  Homosapiens

<400>  224

Met Ala Asn Gly Val Ile Pro Pro Pro Gly Gly Ala Ser Pro Leu Pro 
1               5                   10                  15      


Gln Val Arg Val Pro Leu Glu Glu Pro Pro Leu Ser Pro Asp Val Glu 
            20                  25                  30          


Glu Glu Asp Asp Asp Leu Gly Lys Thr Leu Ala Val Ser Arg Phe Gly 
        35                  40                  45              


Asp Leu Ile Ser Lys Pro Pro Ala Trp Asp Pro Glu Lys Pro Ser Arg 
    50                  55                  60                  


Ser Tyr Ser Glu Arg Asp Phe Glu Phe His Arg His Thr Ser His His 
65                  70                  75                  80  


Thr His His Pro Leu Ser Ala Arg Leu Pro Pro Pro His Lys Leu Arg 
                85                  90                  95      


Arg Leu Pro Pro Thr Ser Ala Arg His Thr Arg Arg Lys Arg Lys Lys 
            100                 105                 110         


Glu Lys Thr Ser Ala Pro Pro Ser Glu Gly Thr Pro Pro Ile Gln Glu 
        115                 120                 125             


Glu Gly Gly Ala Gly Val Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Gly Glu Ser Glu Ala Glu Pro Val Glu Pro Pro Pro Ser Gly Thr 
145                 150                 155                 160 


Pro Gln Lys Ala Lys Phe Ser Ile Gly Ser Asp Glu Asp Asp Ser Pro 
                165                 170                 175     


Gly Leu Pro Gly Arg Ala Ala Val Thr Lys Pro Leu Pro Ser Val Gly 
            180                 185                 190         


Pro His Thr Asp Lys Ser Pro Gln His Ser Ser Ser Ser Pro Ser Pro 
        195                 200                 205             


Arg Ala Arg Ala Ser Arg Leu Ala Gly Glu Lys Ser Arg Pro Trp Ser 
    210                 215                 220                 


Pro Ser Ala Ser Tyr Asp Leu Arg Glu Arg Leu Cys Pro Gly Ser Ala 
225                 230                 235                 240 


Leu Gly Asn Pro Gly Gly Pro Glu Gln Gln Val Pro Thr Asp Glu Ala 
                245                 250                 255     


Glu Ala Gln Met Leu Gly Ser Ala Asp Leu Asp Asp Met Lys Ser His 
            260                 265                 270         


Arg Leu Glu Asp Asn Pro Gly Val Arg Arg His Leu Val Lys Lys Pro 
        275                 280                 285             


Ser Arg Thr Gln Gly Gly Arg Gly Ser Pro Ser Gly Leu Ala Pro Ile 
    290                 295                 300                 


Leu Arg Arg Lys Lys Lys Lys Lys Lys Leu Asp Arg Arg Pro His Glu 
305                 310                 315                 320 


Val Phe Val Glu Leu Asn Glu Leu Met Leu Asp Arg Ser Gln Glu Pro 
                325                 330                 335     


His Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu 
            340                 345                 350         


Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe 
        355                 360                 365             


Arg Ser Leu Leu Glu Leu Arg Arg Thr Ile Ala His Gly Ala Ala Leu 
    370                 375                 380                 


Leu Asp Leu Glu Gln Thr Thr Leu Pro Gly Ile Ala His Leu Val Val 
385                 390                 395                 400 


Glu Thr Met Ile Val Ser Asp Gln Ile Arg Pro Glu Asp Arg Ala Ser 
                405                 410                 415     


Val Leu Arg Thr Leu Leu Leu Lys His Ser His Pro Asn Asp Asp Lys 
            420                 425                 430         


Asp Ser Gly Phe Phe Pro Arg Asn Pro Ser Ser Ser Ser Met Asn Ser 
        435                 440                 445             


Val Leu Gly Asn His His Pro Thr Pro Ser His Gly Pro Asp Gly Ala 
    450                 455                 460                 


Val Pro Thr Met Ala Asp Asp Leu Gly Glu Pro Ala Pro Leu Trp Pro 
465                 470                 475                 480 


His Asp Pro Asp Ala Lys Glu Lys Pro Leu His Met Pro Gly Gly Asp 
                485                 490                 495     


Gly His Arg Gly Lys Ser Leu Lys Leu Leu Glu Lys Ile Pro Glu Asp 
            500                 505                 510         


Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Pro Phe Leu Glu Gln 
        515                 520                 525             


Pro Ala Ala Ala Phe Val Arg Leu Asn Glu Ala Val Leu Leu Glu Ser 
    530                 535                 540                 


Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Val Met Leu Gly 
545                 550                 555                 560 


Pro Ser His Thr Ser Thr Asp Tyr His Glu Leu Gly Arg Ser Ile Ala 
                565                 570                 575     


Thr Leu Met Ser Asp Lys Leu Phe His Glu Ala Ala Tyr Gln Ala Asp 
            580                 585                 590         


Asp Arg Gln Asp Leu Leu Ser Ala Ile Ser Glu Phe Leu Asp Gly Ser 
        595                 600                 605             


Ile Val Ile Pro Pro Ser Glu Val Glu Gly Arg Asp Leu Leu Arg Ser 
    610                 615                 620                 


Val Ala Ala Phe Gln Arg Glu Leu Leu Arg Lys Arg Arg Glu Arg Glu 
625                 630                 635                 640 


Gln Thr Lys Val Glu Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Gly 
                645                 650                 655     


Lys Glu Leu Ser Leu Glu Leu Gly Gly Ser Glu Ala Thr Pro Glu Asp 
            660                 665                 670         


Asp Pro Leu Leu Arg Thr Gly Ser Val Phe Gly Gly Leu Val Arg Asp 
        675                 680                 685             


Val Arg Arg Arg Tyr Pro His Tyr Pro Ser Asp Leu Arg Asp Ala Leu 
    690                 695                 700                 


His Ser Gln Cys Val Ala Ala Val Leu Phe Ile Tyr Phe Ala Ala Leu 
705                 710                 715                 720 


Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Glu Gly 
                725                 730                 735     


Leu Met Gly Val Ser Glu Leu Ile Val Ser Thr Ala Val Leu Gly Val 
            740                 745                 750         


Leu Phe Ser Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe Ser 
        755                 760                 765             


Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Lys Phe Cys Arg Ala 
    770                 775                 780                 


Gln Asp Leu Glu Tyr Leu Thr Gly Arg Val Trp Val Gly Leu Trp Leu 
785                 790                 795                 800 


Val Val Phe Val Leu Ala Leu Val Ala Ala Glu Gly Ser Phe Leu Val 
                805                 810                 815     


Arg Tyr Ile Ser Pro Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
            820                 825                 830         


Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Tyr Lys Val Phe Thr 
        835                 840                 845             


Glu His Pro Leu Leu Pro Phe Tyr Pro Pro Glu Gly Ala Leu Glu Gly 
    850                 855                 860                 


Ser Leu Ala Ala Gly Leu Glu Pro Asn Gly Ser Ala Leu Pro Pro Thr 
865                 870                 875                 880 


Glu Gly Pro Pro Ser Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu Ser 
                885                 890                 895     


Leu Ile Leu Met Leu Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg Lys 
            900                 905                 910         


Phe Arg Asn Ser Arg Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile Gly 
        915                 920                 925             


Asp Phe Gly Ile Pro Ile Ser Ile Leu Val Met Val Leu Val Asp Tyr 
    930                 935                 940                 


Ser Ile Thr Asp Thr Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly Leu 
945                 950                 955                 960 


Ser Val Thr Ser Pro Asp Lys Arg Ser Trp Phe Ile Pro Pro Leu Gly 
                965                 970                 975     


Ser Ala Arg Pro Phe Pro Pro Trp Met Met Val Ala Ala Ala Val Pro 
            980                 985                 990         


Ala Leu Leu Val Leu Ile Leu Ile  Phe Met Glu Thr Gln  Ile Thr Ala 
        995                 1000                 1005             


Leu Ile  Val Ser Gln Lys Ala  Arg Arg Leu Leu Lys  Gly Ser Gly 
    1010                 1015                 1020             


Phe His  Leu Asp Leu Leu Leu  Ile Gly Ser Leu Gly  Gly Leu Cys 
    1025                 1030                 1035             


Gly Leu  Phe Gly Leu Pro Trp  Leu Thr Ala Ala Thr  Val Arg Ser 
    1040                 1045                 1050             


Val Thr  His Val Asn Ala Leu  Thr Val Met Arg Thr  Ala Ile Ala 
    1055                 1060                 1065             


Pro Gly  Asp Lys Pro Gln Ile  Gln Glu Val Arg Glu  Gln Arg Val 
    1070                 1075                 1080             


Thr Gly  Val Leu Ile Ala Ser  Leu Val Gly Leu Ser  Ile Val Met 
    1085                 1090                 1095             


Gly Ala  Val Leu Arg Arg Ile  Pro Leu Ala Val Leu  Phe Gly Ile 
    1100                 1105                 1110             


Phe Leu  Tyr Met Gly Val Thr  Ser Leu Ser Gly Ile  Gln Leu Ser 
    1115                 1120                 1125             


Gln Arg  Leu Leu Leu Ile Leu  Met Pro Ala Lys His  His Pro Glu 
    1130                 1135                 1140             


Gln Pro  Tyr Val Thr Lys Val  Lys Thr Trp Arg Met  His Leu Phe 
    1145                 1150                 1155             


Thr Cys  Ile Gln Leu Gly Cys  Ile Ala Leu Leu Trp  Val Val Lys 
    1160                 1165                 1170             


Ser Thr  Ala Ala Ser Leu Ala  Phe Pro Phe Leu Leu  Leu Leu Thr 
    1175                 1180                 1185             


Val Pro  Leu Arg His Cys Leu  Leu Pro Arg Leu Phe  Gln Asp Arg 
    1190                 1195                 1200             


Glu Leu  Gln Ala Leu Asp Ser  Glu Asp Ala Glu Pro  Asn Phe Asp 
    1205                 1210                 1215             


Glu Asp  Gly Gln Asp Glu Tyr  Asn Glu Leu His Met  Pro Val 
    1220                 1225                 1230         


<210>  225
<211>  613
<212>  DNA
<213>  Homosapiens

<400>  225
atgcatgaga gtgaaaaaga gaacaatcct cagggaaagc ccttgacttc acgctcgcct     60

cgaagctttc gcaaagtaga tacggggact gaccctgttg acacactaac ccaaactcgc    120

agacgcgtgg ggctcgcatg tacccaagac aggaaaactt cacgttggcc tggaaacttc    180

ttccaggcta agcctgagtc ttcaccagac actgcagcac gaaggccctt ctgccttttg    240

gctcgccctg gcccagaatg cgcaccagcc ggcaagagaa agaggcccac tgcaatatgc    300

tgtgaagaat acataagaag tcaaactgtt gacctctttt ccccagcccg ttccaaaact    360

acatccctga ggagttgtgc acctctacgg aaagttcaga tgaaagagct aattcccctt    420

gatctctctt cttgttcaga gtggaggaaa aacatatacc atcccttcca tcaatcctca    480

gcataacttt gccagggaca ctggtaacaa gctactttta cctcagaagt tggagagtat    540

cacttgaccc acattgtgta tgtgtaaata tctttattca gtgtatatac aatatattct    600

taatttgact ctc                                                       613


<210>  226
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  226

Met His Glu Ser Glu Lys Glu Asn Asn Pro Gln Gly Lys Pro Leu Thr 
1               5                   10                  15      


Ser Arg Ser Pro Arg Ser Phe Arg Lys Val Asp Thr Gly Thr Asp Pro 
            20                  25                  30          


Val Asp Thr Leu Thr Gln Thr Arg Arg Arg Val Gly Leu Ala Cys Thr 
        35                  40                  45              


Gln Asp Arg Lys Thr Ser Arg Trp Pro Gly Asn Phe Phe Gln Ala Lys 
    50                  55                  60                  


Pro Glu Ser Ser Pro Asp Thr Ala Ala Arg Arg Pro Phe Cys Leu Leu 
65                  70                  75                  80  


Ala Arg Pro Gly Pro Glu Cys Ala Pro Ala Gly Lys Arg Lys Arg Pro 
                85                  90                  95      


Thr Ala Ile Cys Cys Glu Glu Tyr Ile Arg Ser Gln Thr Val Asp Leu 
            100                 105                 110         


Phe Ser Pro Ala Arg Ser Lys Thr Thr Ser Leu Arg Ser Cys Ala Pro 
        115                 120                 125             


Leu Arg Lys Val Gln Met Lys Glu Leu Ile Pro Leu Asp Leu Ser Ser 
    130                 135                 140                 


Cys Ser Glu Trp Arg Lys Asn Ile Tyr His Pro Phe His Gln Ser Ser 
145                 150                 155                 160 


Ala 
    


<210>  227
<211>  1541
<212>  DNA
<213>  Homosapiens

<400>  227
gcgtgggtcc ggctttcggt gactagacgg tccgcagggg acatcccgtc cctggggcct     60

ccccagtctc cctccccctc gcgcctgggc agctctctcc cagggcttcg gctcgagcct    120

gcgacctgca cggacacccc cccctcagga tctaaaatgt ccactgaggc acaaagagtt    180

gatgacagtc caagcactag tggaggaagt tccgatggag atcaacgtga aagtgttcag    240

caagaaccag aaagagaaca agttcagccc aagaaaaagg agggaaaaat atccagcaaa    300

accgctgcta aattgtcaac tagtgctaaa agaattcaga aggaacttgc agaaatcaca    360

ttggaccctc ctcccaactg tagtgctgga cccaaaggag acaacattta tgaatggagg    420

tcaactatat tgggaccccc aggatctgtc tatgaaggag gggtgttctt tcttgacatt    480

accttttcac cagactatcc gtttaaaccc cctaaggtta ccttccgaac aagaatctat    540

cactgtaata ttaacagcca aggtgtgatc tgtctggaca tcttaaagga caactggagt    600

ccggctttaa ctatttctaa agttctcctc tccatctgct cacttcttac agattgcaac    660

cctgctgacc ctctggtggg cagcatcgcc acacagtaca tgaccaacag agcagagcat    720

gaccggatgg ccagacagtg gaccaagcgg tacgccacat aggggcctgc tgcctgccgc    780

cccgcgggac ctgtgcaagc acattcacca agtgcatcgg tagccctgcc cacccctcca    840

gacctcggtt cttattttcc tatttttatt aaatttggaa ccattttgtg atggtatgtt    900

gtccatcttc ccatcccagt tcttcctgcc ccccttcctc tctcccacgc tctcttttat    960

ctctcatttt attcccttgt tgatttctgt taacttgaaa gatttgggat ttttttccca   1020

cctcatcata gatgggaact tttgttttca gtgcaaacaa tgttggagct gtaatagtaa   1080

gagctttctt acaaagcttt gtattactgt gtggttttgt tttttttgtt gttgtttatt   1140

tgattttgat ttttttttct tttatgtgat ctttgggaaa acacattcag aattatatct   1200

cgtttctact taaatgtagt gcttagggtt aattttttgt actgaagtct ttattggtgg   1260

gtgcatgcta ctgggaacaa gtttttgtac aaaagcttca atcagaatca ctgtgcatta   1320

ctgagactct gtttatcact agccttctgt ccctcccgca gaagactgtt ggattgaaca   1380

aaataatatg tattttgatt tacttaaagt gcttgtaaat ttcttaggga cctgccactt   1440

ttgactgtgg atcagttgat gtacacttgt attattaaag cactcaataa atcactgtgg   1500

ctgataactg cgaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1541


<210>  228
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  228

Met Ser Thr Glu Ala Gln Arg Val Asp Asp Ser Pro Ser Thr Ser Gly 
1               5                   10                  15      


Gly Ser Ser Asp Gly Asp Gln Arg Glu Ser Val Gln Gln Glu Pro Glu 
            20                  25                  30          


Arg Glu Gln Val Gln Pro Lys Lys Lys Glu Gly Lys Ile Ser Ser Lys 
        35                  40                  45              


Thr Ala Ala Lys Leu Ser Thr Ser Ala Lys Arg Ile Gln Lys Glu Leu 
    50                  55                  60                  


Ala Glu Ile Thr Leu Asp Pro Pro Pro Asn Cys Ser Ala Gly Pro Lys 
65                  70                  75                  80  


Gly Asp Asn Ile Tyr Glu Trp Arg Ser Thr Ile Leu Gly Pro Pro Gly 
                85                  90                  95      


Ser Val Tyr Glu Gly Gly Val Phe Phe Leu Asp Ile Thr Phe Ser Pro 
            100                 105                 110         


Asp Tyr Pro Phe Lys Pro Pro Lys Val Thr Phe Arg Thr Arg Ile Tyr 
        115                 120                 125             


His Cys Asn Ile Asn Ser Gln Gly Val Ile Cys Leu Asp Ile Leu Lys 
    130                 135                 140                 


Asp Asn Trp Ser Pro Ala Leu Thr Ile Ser Lys Val Leu Leu Ser Ile 
145                 150                 155                 160 


Cys Ser Leu Leu Thr Asp Cys Asn Pro Ala Asp Pro Leu Val Gly Ser 
                165                 170                 175     


Ile Ala Thr Gln Tyr Met Thr Asn Arg Ala Glu His Asp Arg Met Ala 
            180                 185                 190         


Arg Gln Trp Thr Lys Arg Tyr Ala Thr 
        195                 200     


<210>  229
<211>  7311
<212>  DNA
<213>  Homosapiens

<400>  229
gaggtcagga gattgagacc atcctggcta acacggtgaa accccgtctc tactaaaaat     60

acaaaaaaat tagccgggcg tggcggcggg cgcctgtagt cccagctact tgggaggctg    120

aggcaggaga atggtgcgaa cccgggaggc agattttgca gagagccgag atcgtgccac    180

tgcactccag cctgggcgac agagcaagac tccgtctcaa aacaaaaaac aaacaaacaa    240

atatggagca ttctgatatg aataagacac ttgctcactt ctcaattcct tggtgtccag    300

ctctacaagt gtatatagac ttccaaagaa tatttaaatc ctttaacaaa aatgccacct    360

aagaaaatat gaaatacttc agtctgtctg tcagtgctca cttcctgtct agaaactttc    420

aggctccggc acaaatgaac catgttcttc gcctaagtca tttatggaac atctgctttc    480

ggtttagcat cagtgtgcta ttaatccagg tcttccaaga aacaaatgcc aagatggtat    540

taaacatgaa atgattttaa ttgtttacat gcctgaaagt aaataaagag ggtgccagct    600

aaggctgaaa aagtcttcag tgatataaat tttaccacac ttaaagagag agaggaaaag    660

tttaagtgga agctcctact cagccatgct gtctaaggaa gatttggcaa aaccttgagc    720

taaagtcagc caacggaaat cccacctttc tccaaagaat ggatctgctt tactatcttg    780

cttggtctta ttgctttgtg acctagtaat atctttctcg agtgcatgaa acatctcaga    840

aatgcaaaca tcaaggaaga tactaatcct ttcttccagt ttctgtgtga gggttggagg    900

ctgactttgg tggtgatctt gctccaaatt atagaactac atcctgtcat gaagagaagt    960

ttgtcttctc gataaagcca agtagctaac agagatggtc accccaatta ccagatggac   1020

ataattatac ttgaatgctg acctacaaca ttttgtgctg tgcagaggct ttgaaaatca   1080

aacaactttg aaaatacaaa gcaccgcgtg gatggcctca ctctgtcgct caggctggag   1140

tggcacgatc ttggctcact gcagtctctg cctcctcctc ttggatgcaa gcaattcggc   1200

ctccaagtag ctgagattac agagaggctg aaaactcaag aaatgtggac taagtgtgtg   1260

ggcaagtgtg tcactgctga ctaaaactat gaacagacag agtctcactc tgtcatccag   1320

gctggagtcc agtggtatga tcttggctca ctgcaaacct ttgcctccct ggtccaagtg   1380

attctcctgc ttcagcctcc aaaagtagct aggactacag ctaatcctag tgaatcctcc   1440

atgaggccat tgttctgaat ggaagaagag agatatatgc aataggaaaa ggtgacgtgg   1500

aatctatgag agtcccatgt ttatgtagca tattgtgcct actgtatcta ttcaggaggg   1560

gattcttaat ataagagata catttacaaa attgcttcca ttacctacaa acaccataaa   1620

gaaaagtaac agtgatgcat atggacagaa ctgcatcacc agaagttaga ggaggaaagc   1680

atttcctatc caactttaaa tgctgagaat gaataaccag gaaaaatggt acagaggaca   1740

aaataccaac aaaagtctcc aaaagtgatg tgaagaaaat aaggggctca tcattctaaa   1800

ttctgcagga gagcagtaga agaaatcaag ggaatcccac attatgtggg actctgcgac   1860

tgtattggac acatagaata atctaggata atctctctgt ctcaagatct tcaaatgaat   1920

cgcagctgta acgtcccttt tgccagggaa ggcaatatat tcacagattc tgaggattag   1980

gaatgagacc tccttggagc cattgtttaa cctttcatag gctggataat atagttttgc   2040

aaactcaatt tgggcagctg gacagtgatc aggcaacttt ccgagtccct gactcccacc   2100

tagactgaga ttccaatgct aggtgcccag aagtttccaa ccaatgcaaa ggtggcagct   2160

ggcaagggcc ctgtgcagca gtaaggcgag tcatagactg atgagagatc accattggga   2220

atgagctcca tttgcccaca acagtgatcg gctgatggct ccaccctcta cttagtcgct   2280

tctgtttcct gtcccatgga ttcctcaccc cacactaatg cttccaggaa caacttctca   2340

aataaatcac ttgcacattt ctagatgata tgaattatat tcagacctga agagaggaca   2400

gaaaaattct ggacttcaaa ctcaatgcaa tgattggata agactttcgg agtaacttct   2460

tttgggattg cgtaagagat caagactaca gactttgagg taaaaacaac ctagattcgt   2520

gagaagagga agagtaaaag aactgcagct ttcctcccac tcttaaggta taaatatgaa   2580

gtctaggtca tttcgagttg gagaagcccc agctacttca taagtgtgat gctagttttg   2640

aatgtgcatt gagggacagc tggtgttgag aaaaaaggaa attaccttaa taccaataat   2700

ttcagcacag attgtcatgt ggttgggaaa atatttgata tgaagacatt gaatccacct   2760

tctaaagaat aacaagatat attcatgaat ggaaggattt ggtagggtac atgaggacag   2820

atataaaact gcacaaccaa tgttacacaa aggaggttta ttcttcttca caagaaagtg   2880

atgtgtagag atattcactg aattattgaa gattatatgt ggcagagtca gcttggggat   2940

ccaggttgtc taatccaaag attgtttaac caagaaacaa ggtcaaggca tgttcttcga   3000

tgcttgttca ttaacagctc tgcgggtgat gctcctagag aggtctgatg tgttgtgtga   3060

tgttctcaca caaactatgt taatttttga tcagtgattg tgagttttaa ttgtgttgag   3120

gtaactagag atttgttaag tggacgttac ttcaaaaagg taagttgaag cagtaaatgt   3180

taaaaccaag gaatccccca aattcttgcc ctttattttt tgcatgttaa ttccagaaaa   3240

gaaaaaaaaa aaagcttgtg ggttaacgtg gtatttatgc aaggctgcca atgtaaatat   3300

aattctgtga tttaattttt tactggcatg acattatata tatgtataaa atgtgcatac   3360

ataatatata catatgtata tatgttatat attagatgtg tatgcatata taatatatat   3420

tagatgtata aaatatatta catatataat aaaatattag atatgtatta tatagtagta   3480

tatataaaat atatacatat ctaataatac attatagatc atgtattaat atatacatat   3540

atctagtata tacaatatat acatatctat tatatttata cacacataca tatacatatg   3600

tgtatgtgta tgtctgtgcc tgtgtgtctt tttgtcttgc aagctcaatc tttaaaaaga   3660

agagttcgag gagggatgga gaaggaagag agtgattata tatacatata ctgtccatgt   3720

ttgcttagct agtatgaagc agaatctgga ttcaaattca agaagtctga ttcccaaaca   3780

gccacccaat taggaccgct ttgaaaactc cgagtcttct atttgatata agtatagctc   3840

attgccatgg aaataaacat atgtttcttt tttaaattaa aaaaaatatt tttattttgt   3900

tttcaacatt tagcattttt ttgcatcaaa gttctaagta gctgcatgtc tgtttataat   3960

gtgtatattt gttgtttgtt tttctgtttt gtttctgtat agtttctttg tttgtatcac   4020

tggtaattta atccctcatg ctatgctgtg ggattatgta caacaacaca acttcttagc   4080

ctcttcaaac cctttcactg caagctgctt ttttgtgctt tttgaaagaa aaggaagaaa   4140

aacacattgc attttcttaa gataaaatga tacctgcttc ttcatttcct cctactcctt   4200

cctattatct tttgtagaaa gaattgctga atctattgat atgtaatttt catttaattc   4260

tccaacatct tattgctatt taaaatggtt taagaaaact ggcttaatat agccaagaaa   4320

aattctatag taatacttgt ctgtaatttc tctatattta aataaaatat catttctatc   4380

ttggaggttt gatttggcca tttaaaaatg ctaatgtttt attgtttttt caaaaaaata   4440

ctacatgcat gctcatagta taaacatcaa tgtttcatta ggatatatag tgaaaagtca   4500

gtaactttac aacctctgtt tcaaacccaa ccagtaattt aagttgtttt cataacaaag   4560

tgttattatt tatcttctaa tacctataaa atatttattt actccccaaa ttaaatagag   4620

tgttggttct tcaatgaagg tatgaagtta ctttcaatta aatatgcagt ttgattagaa   4680

gaaaaaaaaa tccatcagat ctcagccaag ctcttttgga tgattatttt tcttcaaaat   4740

caaatacact aaaatttcca aacagtaaca gttacaatgt ttcagtttct tttaaggtag   4800

cctgaactga gacacattaa ggtttatatc taatttcata gttctgttca gtaggaaata   4860

agtaaattag tttaaaggac tgatccatat caggagatca ggactggaca aagtgttaat   4920

ttatctacag attttaccag gcagattgcc aatatccaag ttcattagac aggtcctagg   4980

actaataaga actcttgggg gctacaatgt gaaatacctg agtatatgag tcaggtaaag   5040

actttagaaa gtttggcttc tactctcata ttcccaggag ttgaatagat tggagtggaa   5100

aaaatgtggt caaaaactag tgattttgga ttagaagtag ggcataaagc tcctattatt   5160

gcacttgggc aatattaact ggattgcaag aaactgtaat atgcagaaac agcatatttc   5220

ccttagggag tacattttgt taaacttagt attcttgcta cctgttttgt tacctaagct   5280

taatggacct ggccctagac tttagcttgg tgcatggtga aaattgacct taagcaactg   5340

cagcattgtc caaatatttg gtttcacata gaccagtttt ggttcttgtt tctgtgtgac   5400

tttgaggggc tctttaagaa atccaaggac aaggtgccac atttattaag gccccgccat   5460

tcacaatgca tgatgctaga gcctgacagt gcaccatgct agagactgaa gagacataaa   5520

aaaaagaaaa ggcagagttc ttgctatcag gttcttaaaa ttttctttgt tttggttaaa   5580

ttcttgattg gattttttca ctaaatgttt ggccctatta aaaataagta aagaaaaaat   5640

gaaggaagaa tggaagagag ggagaatagg aaatgaatga aacaaagcca agtaagagat   5700

acgtctacta cagacctgca agttggcagt gcttgcagaa gacagttgac atattctagc   5760

ctggttcaca ttttctggtt aacttttgag catagaataa agaatataat aaaatgcttt   5820

tttttttttt tgcacaatga actttaaaca aatcaggaga gtatattggt aatttagaga   5880

agtagcaatt ctcattaaat ctgtttttca ttgaattatc atgcccttaa aattatatga   5940

tagattatta tcttcggtag tattagttta aataagaatt atatacaacc aaaatatcag   6000

taaggctaat tctctgagac cataagagaa ccaagtcaat atccccatag ctacatcata   6060

ttgatcattc atttgattta agaagaaaga agacaaatat gttagtgaaa gggagacaaa   6120

tgagtatgtg cctggcctgg ccaattcctg actcatttac agaggaagct aatataactc   6180

tcttactcat tttatgggaa atatgataga tctgattata taatttatgc ctcctttcag   6240

acttcctaca ccccactaat tgtctcttcc tttcttttct ccaccttttg ctcaggtatt   6300

tggcagttat tgcacttttt tggatctttt ttttaaggat gttactatca atcttttgcc   6360

tacatctaaa tgacttacct atgaagaaga tcccattttt agccttaata tttgcaaatt   6420

acttgagaga tggagtctca ctctatcacc caggctggag gacagtggca cgacctcagc   6480

tccctgcaac ctccacctcc caggttactg atggatccgt cctaaatgcc atccatctca   6540

agacagaggc ccacagaagt caatgtatct tcaagatggg agtacctgga gatggctgta   6600

gagaccatgt agcaggaaat ggtgacagag aagagctggg cctctggtac caacatgctt   6660

cccccccgtt acagctatgc gggctgatag tgacgcaatg tgtggtttca atacttcata   6720

gtgtcttact tcacctcagt ataaagtact ttgaaagcat caaggaaatg gtcctcaaaa   6780

aaggcttatc cagtcaggac atctggtgct ggctctggaa tgagtggatg aagataaggc   6840

cttccagtat ggaggtgata aaaatcaggg aagacaggta atcacaatgg atgacagacc   6900

aggattccca gatatcttgg catggctgga acaatgtaca gatcaaacca tgtaaaactt   6960

aatgggtata aaccaactct tcactttggt ctaaaaaagt ccatttgcat ggcttctagt   7020

taaaggtgga caggctcact ttagaatcct attatataca aaggatttag ggggtttagt   7080

tcacaatgtg ctaaagccat ctcacagtga ccatggtatg agctgtgtga tttggtttaa   7140

atataataga gaatgaagga caaggttgag ggtggtggtt acagtcctgc ctgattctgt   7200

agtgctcagg tgacctttga agaatgaaga aagaagtcaa aaccccacac tattaagaca   7260

ttggaagact gggaatgttt attttctgaa gaataaaaga tgtaggaaac a            7311


<210>  230
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  230

Met Lys Lys Ile Pro Phe Leu Ala Leu Ile Phe Ala Asn Tyr Leu Arg 
1               5                   10                  15      


Asp Gly Val Ser Leu Tyr His Pro Gly Trp Arg Thr Val Ala Arg Pro 
            20                  25                  30          


Gln Leu Pro Ala Thr Ser Thr Ser Gln Val Thr Asp Gly Ser Val Leu 
        35                  40                  45              


Asn Ala Ile His Leu Lys Thr Glu Ala His Arg Ser Gln Cys Ile Phe 
    50                  55                  60                  


Lys Met Gly Val Pro Gly Asp Gly Cys Arg Asp His Val Ala Gly Asn 
65                  70                  75                  80  


Gly Asp Arg Glu Glu Leu Gly Leu Trp Tyr Gln His Ala Ser Pro Pro 
                85                  90                  95      


Leu Gln Leu Cys Gly Leu Ile Val Thr Gln Cys Val Val Ser Ile Leu 
            100                 105                 110         


His Ser Val Leu Leu His Leu Ser Ile Lys Tyr Phe Glu Ser Ile Lys 
        115                 120                 125             


Glu Met Val Leu Lys Lys Gly Leu Ser Ser Gln Asp Ile Trp Cys Trp 
    130                 135                 140                 


Leu Trp Asn Glu Trp Met Lys Ile Arg Pro Ser Ser Met Glu Val Ile 
145                 150                 155                 160 


Lys Ile Arg Glu Asp Arg 
                165     


<210>  231
<211>  3309
<212>  DNA
<213>  Homosapiens

<400>  231
ctgcaggggg gggggggggg gggggggggg ggggggggcg cagcacggct cagaccgagg     60

cgcacaggct cgcagctccg ggcgcctagc gcccggtccc cgccgcgacg cgccaccgtc    120

cctgccggcg cctccgcgcc ttcgaaatga gggtcctggg tgggcgctgc ggggcgccgc    180

tggcgtgtct cctcctagtg cttcccgtct cagaggcaaa ccttctgtca aagcaacagg    240

cttcacaagt cctggttagg aagcgtcgtg caaattcttt acttgaagaa accaaacagg    300

gtaatcttga aagagaatgc atcgaagaac tgtgcaataa agaagaagcc agggaggtct    360

ttgaaaatga cccggaaacg gattattttt atccaaaata cttagtttgt cttcgctctt    420

ttcaaactgg gttattcact gctgcacgtc agtcaactaa tgcttatcct gacctaagaa    480

gctgtgtcaa tgccattcca gaccagtgta gtcctctgcc atgcaatgaa gatggatata    540

tgagctgcaa agatggaaaa gcttctttta cttgcacttg taaaccaggt tggcaaggag    600

aaaagtgtga atttgacata aatgaatgca aagatccctc aaatataaat ggaggttgca    660

gtcaaatttg tgataataca cctggaagtt accactgttc ctgtaaaaat ggttttgtta    720

tgctttcaaa taagaaagat tgtaaagatg tggatgaatg ctctttgaag ccaagcattt    780

gtggcacagc tgtgtgcaag aacatcccag gagattttga atgtgaatgc cccgaaggct    840

acagatataa tctcaaatca aagtcttgtg aagatataga tgaatgctct gagaacatgt    900

gtgctcagct ttgtgtcaat taccctggag gttacacttg ctattgtgat gggaagaaag    960

gattcaaact tgcccaagat cagaagagtt gtgaggttgt ttcagtgtgc cttcccttga   1020

accttgacac aaagtatgaa ttactttact tggcggagca gtttgcaggg gttgttttat   1080

atttaaaatt tcgtttgcca gaaatcagca gattttcagc agaatttgat ttccggacat   1140

atgattcaga aggcgtgata ctgtacgcag aatctatcga tcactcagcg tggctcctga   1200

ttgcacttcg tggtggaaag attgaagttc agcttaagaa tgaacataca tccaaaatca   1260

caactggagg tgatgttatt aataatggtc tatggaatat ggtgtctgtg gaagaattag   1320

aacatagtat tagcattaaa atagctaaag aagctgtgat ggatataaat aaacctggac   1380

ccctttttaa gccggaaaat ggattgctgg aaaccaaagt atactttgca ggattccctc   1440

ggaaagtgga aagtgaactc attaaaccga ttaaccctcg tctagatgga tgtatacgaa   1500

gctggaattt gatgaagcaa ggagcttctg gaataaagga aattattcaa gaaaaacaaa   1560

ataagcattg cctggttact gtggagaagg gctcctacta tcctggttct ggaattgctc   1620

aatttcacat agattataat aatgtatcca gtgctgaggg ttggcatgta aatgtgacct   1680

tgaatattcg tccatccacg ggcactggtg ttatgcttgc cttggtttct ggtaacaaca   1740

cagtgccctt tgctgtgtcc ttggtggact ccacctctga aaaatcacag gatattctgt   1800

tatctgttga aaatactgta atatatcgga tacaggccct aagtctatgt tccgatcaac   1860

aatctcatct ggaatttaga gtcaacagaa acaatctgga gttgtcgaca ccacttaaaa   1920

tagaaaccat ctcccatgaa gaccttcaaa gacaacttgc cgtcttggac aaagcaatga   1980

aagcaaaagt ggccacatac ctgggtggcc ttccagatgt tccattcagt gccacaccag   2040

tgaatgcctt ttataatggc tgcatggaag tgaatattaa tggtgtacag ttggatctgg   2100

atgaagccat ttctaaacat aatgatatta gagctcactc atgtccatca gtttggaaaa   2160

agacaaagaa ttcttaaggc atcttttctc tgcttataat accttttcct tgtgtgtaat   2220

tatacttatg tttcaataac agctgaaggg ttttatttac aatgtgcagt ctttgattat   2280

tttgtggtcc tttcctggga tttttaaaag gtcctttgtc aaggaaaaaa attctgttgt   2340

gatataaatc acagtaaaga aattcttact tctcttgcta tctaagaata gtgaaaaata   2400

acaattttaa atttgaattt ttttcctaca aatgacagtt tcaatttttg tttgtaaaac   2460

taaattttaa ttttatcatc atgaactagt gtctaaatac ctatgttttt ttcagaaagc   2520

aaggaagtaa actcaaacaa aagtgcgtgt aattaaatac tattaatcat aggcagatac   2580

tattttgttt atgtttttgt ttttttcctg atgaaggcag aagagatggt ggtctattaa   2640

atatgaattg aatggagggt cctaatgcct tatttcaaaa caattcctca gggggaccag   2700

ctttggcttc atctttctct tgtgtggctt cacatttaaa ccagtatctt tattgaatta   2760

gaaaacaagt gggacatatt ttcctgagag cagcacagga atcttcttct tggcagctgc   2820

agtctgtcag gatgagatat cagattaggt tggataggtg gggaaatctg aagtgggtac   2880

attttttaaa ttttgctgtg tgggtcacac aaggtctaca ttacaaaaga cagaattcag   2940

ggatggaaag gagaatgaac aaatgtggga gttcatagtt ttccttgaat ccaactttta   3000

attaccagag taagttgcca aaatgtgatt gttgaagtac aaaaggaact atgaaaacca   3060

gaacaaattt taacaaaagg acaaccacag agggatatag tgaatatcgt atcattgtaa   3120

tcaaagaagt aaggaggtaa gattgccacg tgcctgctgg tactgtgatg catttcaagt   3180

ggcagtttta tcacgtttga atctaccatt catagccaga tgtgtatcag atgtttcact   3240

gacagttttt aacaataaat tcttttcact gtattttata tcacttataa taaatcggtg   3300

tataatttt                                                           3309


<210>  232
<211>  676
<212>  PRT
<213>  Homosapiens

<400>  232

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Pro Leu Ala Cys Leu Leu 
1               5                   10                  15      


Leu Val Leu Pro Val Ser Glu Ala Asn Leu Leu Ser Lys Gln Gln Ala 
            20                  25                  30          


Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
        35                  40                  45              


Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
    50                  55                  60                  


Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
65                  70                  75                  80  


Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 
                85                  90                  95      


Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser 
            100                 105                 110         


Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu 
        115                 120                 125             


Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr 
    130                 135                 140                 


Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu 
145                 150                 155                 160 


Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 
                165                 170                 175     


Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 
            180                 185                 190         


Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 
        195                 200                 205             


Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 
    210                 215                 220                 


Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser 
225                 230                 235                 240 


Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys 
                245                 250                 255     


Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly 
            260                 265                 270         


Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys 
        275                 280                 285             


Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 
    290                 295                 300                 


Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 
305                 310                 315                 320 


Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 
                325                 330                 335     


Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile 
            340                 345                 350         


Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr 
        355                 360                 365             


Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn 
    370                 375                 380                 


Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala 
385                 390                 395                 400 


Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro 
                405                 410                 415     


Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 
            420                 425                 430         


Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 
        435                 440                 445             


Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 
    450                 455                 460                 


Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu 
465                 470                 475                 480 


Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp 
                485                 490                 495     


Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu 
            500                 505                 510         


Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser 
        515                 520                 525             


Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser 
    530                 535                 540                 


Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 
545                 550                 555                 560 


Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 
                565                 570                 575     


Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 
            580                 585                 590         


Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp 
        595                 600                 605             


Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp 
    610                 615                 620                 


Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met 
625                 630                 635                 640 


Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser 
                645                 650                 655     


Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys 
            660                 665                 670         


Thr Lys Asn Ser 
        675     


<210>  233
<211>  3451
<212>  DNA
<213>  Homosapiens

<400>  233
cagcacgtcg acgcggggct tttctttagc cgggtcccgc taactcggct acggtgtatc     60

tgcgtctttg gtcaggttgt tccttggcta agagggcagt cgtcgcggac ccacgcggtt    120

agcaaggctt agtgctcggg ccggccgcct tcacttccct cccggctttt cctcccgact    180

tatccacttt aggggcgtct cggagtgccg gaggcccccg gggaagagcg gggtgccggt    240

gtccgctccg ggctcggatg ggaagtggtg ggaggagcga cccgggatgt tcagtctgat    300

ggccagttgc tgcggctggt tcaagcggtg gcgggagcct gtcagaaagg tgactctttt    360

gatggtggga cttgataatg ctggtaaaac cgcaacagca aagggaatcc aaggagaata    420

ccctgaagat gtagctccta ctgttggatt ttcaaaaatt aaccttagac aaggaaagtt    480

tgaagtcacc atctttgact tgggaggtgg aataagaatt cggggaatct ggaagaatta    540

ctatgctgaa tcctatgggg taatatttgt tgtggattcc agtgatgaag agagaatgga    600

agagacaaaa gaggctatgt cagaaatgct aagacatcct aggatatcgg gaaagcctat    660

attggtgttg gcaaataaac aagataaaga aggagcttta ggagaagctg atgtcattga    720

atgtctatct ctggaaaaat tggtcaatga gcacaagtgc ctgtgtcaga tagaaccatg    780

ttcagcaatc tcggggtatg gaaagaaaat tgacaagtcc attaaaaaag gcctttattg    840

gctgctacat gttattgcaa gagactttga tgccttaaat gaacgcatcc aaaaagagac    900

aacagagcag cgtgctcttg aggaacaaga gaaacaagaa agagctgaac gagtgcgaaa    960

attacgagaa gaaagaaaac aaaatgaaca ggagcaggct gaactcgatg gaaccagtgg   1020

tctggctgag ttggacccag aaccaacgaa tcctttccag ccaatagcat ctgtaatcat   1080

tgagaatgaa ggaaaacttg aaagagagaa aaaaaaccaa aaaatggaga aagacagtga   1140

tggctgccac ctgaaacata aaatggagca tgagcaaata gagacacaag gccaggttaa   1200

tcacaatggc caaaaaaata atgaatttgg actagtagaa aattataagg aggcattaac   1260

acagcagtta aagaatgaag atgagacaga ccggccatca ttggaatcag ctaatggtaa   1320

aaagaaaact aagaaactaa gaatgaaaag gaaccaccgg gtagaaccac ttaatataga   1380

tgactgtgct cctgagagtc caacgccacc cccaccccct cctcctgttg gctggggaac   1440

ccctaaagtc actagacttc caaaacttga gcctcttggt gaaacacatc ataatgattt   1500

ctataggaag ccactgcctc ccctggctgt gccacagcga cctaacagtg atgctcatga   1560

tgtgatctca taaacaagac gtatggagga gttctcttaa tatcagcaag aagcacaatg   1620

accagtacat gaaatcagca tttggaccaa attagcaaga tttactgttg actctggttt   1680

atacatcccc actcatgagc atacttctga aggaaaactt tacaaaaaga gccaatggac   1740

tcagcacttt ctttactatt tgttcaatag cctatatttc tagatattaa atattttttg   1800

taagatatat gcacatagaa gggggacttc taggaattta taaccaaaat tttaaaacta   1860

tttttatatt tttttaaatc tttaaaaatt ttaattactg tgatattgat tatacacctt   1920

ttttatagat gatttgttta aattatatct ggaaaataga gttgatttac tttcagacat   1980

gaactataca aacaggatat atttatatgg cttgaggtat gttttgtaat agcgttgttc   2040

tttaagtgta catcgtaatt tgacctaatt taaaaataat atattttcga agtagtagat   2100

tctcagatct ttattctaac aattacatga tttgaaaaca gtactcaatg agactggaaa   2160

taccttttgt acctaaatgt tttttaaatt aatcaaaata cattctgtga gatactatta   2220

aaagtctcag taaagtccta ttttaaaggt tagacacttt cagagatcaa ggtgctccct   2280

atactccctt gttccatcag aagctgcagt gactctttta ggtgattcta attctttcat   2340

gccttgaaat taaactatga aattaaaggc agaaaaactg gaaaacctac tgcaggtcca   2400

gagacttctg ttttacaact gggaaacagc ttgtgtacta aagtaatgag aataaaaatg   2460

ttggcccaaa attactttta taaataaata attccaaaat aatttcttaa tttaaaatga   2520

tagcacttct cttgcactta agaatggcat ccataagatt ctgtatttgg catttagact   2580

aacttctaga tgtatatttt taataataga ttcataatgt tacatttaat tgaaaacaaa   2640

cctttatatc caatgaaaat agtataaaca gaatgatttt tataccacct tgttaagatt   2700

ggtgcttttg gtaacttgta ctgacacaac agacatgtgc tagtatctga taacattaag   2760

tacattttat gtcgtttaat ataattattt actttaaaaa ttgtacttca gaacatcaga   2820

ttttattcac attttttaac tcactgaact ttaataatca ggtcacctgt actctagtca   2880

gcactgtata tattcttgga gtttgtacat gggacttagc aaccacactg agtgaggtaa   2940

aagcatttga tttcagatct aaaattcgta acaacctaaa tttgagaggt ggctgaaatg   3000

tgatgaaaag caatacgaaa agacaatgta aactttgaaa aggattttag agggaaaatt   3060

gcatagcttt ttgtaacatt tacttaattt taaaactaaa ctcatacttt tgctatcttt   3120

ttaatattta tctcgtttgg gagtatacgt gtttttaaaa tttgtgtttt ctatctgttt   3180

actatagtgt agctactggc ttcatttaat aaaaataaat gattttgaaa ttaaatataa   3240

tatagaattc acattttata tagctctctc aaaaattaat ttttattcct taagcatttt   3300

aaaaacattt taaaaaatgt tttgtaaatc caggtgtatt ttaacaatta aatgcctatt   3360

ttgttatatg ttatactttt attcttaatt ctgaattttg acattttcac acaataaaaa   3420

taatttatat caaaaaaaaa aaaaaaaaaa a                                  3451


<210>  234
<211>  428
<212>  PRT
<213>  Homosapiens

<400>  234

Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Lys Val Thr Leu Leu Met Val Gly Leu Asp Asn Ala 
            20                  25                  30          


Gly Lys Thr Ala Thr Ala Lys Gly Ile Gln Gly Glu Tyr Pro Glu Asp 
        35                  40                  45              


Val Ala Pro Thr Val Gly Phe Ser Lys Ile Asn Leu Arg Gln Gly Lys 
    50                  55                  60                  


Phe Glu Val Thr Ile Phe Asp Leu Gly Gly Gly Ile Arg Ile Arg Gly 
65                  70                  75                  80  


Ile Trp Lys Asn Tyr Tyr Ala Glu Ser Tyr Gly Val Ile Phe Val Val 
                85                  90                  95      


Asp Ser Ser Asp Glu Glu Arg Met Glu Glu Thr Lys Glu Ala Met Ser 
            100                 105                 110         


Glu Met Leu Arg His Pro Arg Ile Ser Gly Lys Pro Ile Leu Val Leu 
        115                 120                 125             


Ala Asn Lys Gln Asp Lys Glu Gly Ala Leu Gly Glu Ala Asp Val Ile 
    130                 135                 140                 


Glu Cys Leu Ser Leu Glu Lys Leu Val Asn Glu His Lys Cys Leu Cys 
145                 150                 155                 160 


Gln Ile Glu Pro Cys Ser Ala Ile Ser Gly Tyr Gly Lys Lys Ile Asp 
                165                 170                 175     


Lys Ser Ile Lys Lys Gly Leu Tyr Trp Leu Leu His Val Ile Ala Arg 
            180                 185                 190         


Asp Phe Asp Ala Leu Asn Glu Arg Ile Gln Lys Glu Thr Thr Glu Gln 
        195                 200                 205             


Arg Ala Leu Glu Glu Gln Glu Lys Gln Glu Arg Ala Glu Arg Val Arg 
    210                 215                 220                 


Lys Leu Arg Glu Glu Arg Lys Gln Asn Glu Gln Glu Gln Ala Glu Leu 
225                 230                 235                 240 


Asp Gly Thr Ser Gly Leu Ala Glu Leu Asp Pro Glu Pro Thr Asn Pro 
                245                 250                 255     


Phe Gln Pro Ile Ala Ser Val Ile Ile Glu Asn Glu Gly Lys Leu Glu 
            260                 265                 270         


Arg Glu Lys Lys Asn Gln Lys Met Glu Lys Asp Ser Asp Gly Cys His 
        275                 280                 285             


Leu Lys His Lys Met Glu His Glu Gln Ile Glu Thr Gln Gly Gln Val 
    290                 295                 300                 


Asn His Asn Gly Gln Lys Asn Asn Glu Phe Gly Leu Val Glu Asn Tyr 
305                 310                 315                 320 


Lys Glu Ala Leu Thr Gln Gln Leu Lys Asn Glu Asp Glu Thr Asp Arg 
                325                 330                 335     


Pro Ser Leu Glu Ser Ala Asn Gly Lys Lys Lys Thr Lys Lys Leu Arg 
            340                 345                 350         


Met Lys Arg Asn His Arg Val Glu Pro Leu Asn Ile Asp Asp Cys Ala 
        355                 360                 365             


Pro Glu Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Val Gly Trp Gly 
    370                 375                 380                 


Thr Pro Lys Val Thr Arg Leu Pro Lys Leu Glu Pro Leu Gly Glu Thr 
385                 390                 395                 400 


His His Asn Asp Phe Tyr Arg Lys Pro Leu Pro Pro Leu Ala Val Pro 
                405                 410                 415     


Gln Arg Pro Asn Ser Asp Ala His Asp Val Ile Ser 
            420                 425             


<210>  235
<211>  3286
<212>  DNA
<213>  Homosapiens

<400>  235
cagcacgtcg acgcggggct tttctttagc cgggtcccgc taactcggct acggtgtatc     60

tgcgtctttg gtcaggttgt tccttggcta agagggcagt cgtcgcggac ccacgcggtt    120

agcaaggctt agtgctcggg ccggccgcct tcacttccct cccggctttt cctcccgact    180

tatccacttt aggggcgtct cggagtgccg gaggcccccg gggaagagcg gggtgccggt    240

gtccgctccg ggctcggatg ggaagtggtg ggaggagcga cccgggatgt tcagtctgat    300

ggccagttgc tgcggctggt tcaagcggtg gcgggagcct gtcaggttgg caaataaaca    360

agataaagaa ggagctttag gagaagctga tgtcattgaa tgtctatctc tggaaaaatt    420

ggtcaatgag cacaagtgcc tgtgtcagat agaaccatgt tcagcaatct cggggtatgg    480

aaagaaaatt gacaagtcca ttaaaaaagg cctttattgg ctgctacatg ttattgcaag    540

agactttgat gccttaaatg aacgcatcca aaaagagaca acagagcagc gtgctcttga    600

ggaacaagag aaacaagaaa gagctgaacg agtgcgaaaa ttacgagaag aaagaaaaca    660

aaatgaacag gagcaggctg aactcgatgg aaccagtggt ctggctgagt tggacccaga    720

accaacgaat cctttccagc caatagcatc tgtaatcatt gagaatgaag gaaaacttga    780

aagagagaaa aaaaaccaaa aaatggagaa agacagtgat ggctgccacc tgaaacataa    840

aatggagcat gagcaaatag agacacaagg ccaggttaat cacaatggcc aaaaaaataa    900

tgaatttgga ctagtagaaa attataagga ggcattaaca cagcagttaa agaatgaaga    960

tgagacagac cggccatcat tggaatcagc taatggtaaa aagaaaacta agaaactaag   1020

aatgaaaagg aaccaccggg tagaaccact taatatagat gactgtgctc ctgagagtcc   1080

aacgccaccc ccaccccctc ctcctgttgg ctggggaacc cctaaagtca ctagacttcc   1140

aaaacttgag cctcttggtg aaacacatca taatgatttc tataggaagc cactgcctcc   1200

cctggctgtg ccacagcgac ctaacagtga tgctcatgat gtgatctcat aaacaagacg   1260

tatggaggag ttctcttaat atcagcaagg tgaactggga cattcttctt tctcagaaga   1320

agaaacatct tgtaaattga tgactggggc aagataacca taataatttt agtgagaaga   1380

ttaatactca aggacctgac ttgataatta cttatttgtg tttttcatgg ttaaaaaaat   1440

aaaagaagca caatgaccag tacatgaaat cagcatttgg accaaattag caagatttac   1500

tgttgactct ggtttataca tccccactca tgagcatact tctgaaggaa aactttacaa   1560

aaagagccaa tggactcagc actttcttta ctatttgttc aatagcctat atttctagat   1620

attaaatatt ttttgtaaga tatatgcaca tagaaggggg acttctagga atttataacc   1680

aaaattttaa aactattttt atattttttt aaatctttaa aaattttaat tactgtgata   1740

ttgattatac acctttttta tagatgattt gtttaaatta tatctggaaa atagagttga   1800

tttactttca gacatgaact atacaaacag gatatattta tatggcttga ggtatgtttt   1860

gtaatagcgt tgttctttaa gtgtacatcg taatttgacc taatttaaaa ataatatatt   1920

ttcgaagtag tagattctca gatctttatt ctaacaatta catgatttga aaacagtact   1980

caatgagact ggaaatacct tttgtaccta aatgtttttt aaattaatca aaatacattc   2040

tgtgagatac tattaaaagt ctcagtaaag tcctatttta aaggttagac actttcagag   2100

atcaaggtgc tccctatact cccttgttcc atcagaagct gcagtgactc ttttaggtga   2160

ttctaattct ttcatgcctt gaaattaaac tatgaaatta aaggcagaaa aactggaaaa   2220

cctactgcag gtccagagac ttctgtttta caactgggaa acagcttgtg tactaaagta   2280

atgagaataa aaatgttggc ccaaaattac ttttataaat aaataattcc aaaataattt   2340

cttaatttaa aatgatagca cttctcttgc acttaagaat ggcatccata agattctgta   2400

tttggcattt agactaactt ctagatgtat atttttaata atagattcat aatgttacat   2460

ttaattgaaa acaaaccttt atatccaatg aaaatagtat aaacagaatg atttttatac   2520

caccttgtta agattggtgc ttttggtaac ttgtactgac acaacagaca tgtgctagta   2580

tctgataaca ttaagtacat tttatgtcgt ttaatataat tatttacttt aaaaattgta   2640

cttcagaaca tcagatttta ttcacatttt ttaactcact gaactttaat aatcaggtca   2700

cctgtactct agtcagcact gtatatattc ttggagtttg tacatgggac ttagcaacca   2760

cactgagtga ggtaaaagca tttgatttca gatctaaaat tcgtaacaac ctaaatttga   2820

gaggtggctg aaatgtgatg aaaagcaata cgaaaagaca atgtaaactt tgaaaaggat   2880

tttagaggga aaattgcata gctttttgta acatttactt aattttaaaa ctaaactcat   2940

acttttgcta tctttttaat atttatctcg tttgggagta tacgtgtttt taaaatttgt   3000

gttttctatc tgtttactat agtgtagcta ctggcttcat ttaataaaaa taaatgattt   3060

tgaaattaaa tataatatag aattcacatt ttatatagct ctctcaaaaa ttaattttta   3120

ttccttaagc attttaaaaa cattttaaaa aatgttttgt aaatccaggt gtattttaac   3180

aattaaatgc ctattttgtt atatgttata cttttattct taattctgaa ttttgacatt   3240

ttcacacaat aaaaataatt tatatcaaaa aaaaaaaaaa aaaaaa                  3286


<210>  236
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  236

Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Leu Ala Asn Lys Gln Asp Lys Glu Gly Ala Leu Gly 
            20                  25                  30          


Glu Ala Asp Val Ile Glu Cys Leu Ser Leu Glu Lys Leu Val Asn Glu 
        35                  40                  45              


His Lys Cys Leu Cys Gln Ile Glu Pro Cys Ser Ala Ile Ser Gly Tyr 
    50                  55                  60                  


Gly Lys Lys Ile Asp Lys Ser Ile Lys Lys Gly Leu Tyr Trp Leu Leu 
65                  70                  75                  80  


His Val Ile Ala Arg Asp Phe Asp Ala Leu Asn Glu Arg Ile Gln Lys 
                85                  90                  95      


Glu Thr Thr Glu Gln Arg Ala Leu Glu Glu Gln Glu Lys Gln Glu Arg 
            100                 105                 110         


Ala Glu Arg Val Arg Lys Leu Arg Glu Glu Arg Lys Gln Asn Glu Gln 
        115                 120                 125             


Glu Gln Ala Glu Leu Asp Gly Thr Ser Gly Leu Ala Glu Leu Asp Pro 
    130                 135                 140                 


Glu Pro Thr Asn Pro Phe Gln Pro Ile Ala Ser Val Ile Ile Glu Asn 
145                 150                 155                 160 


Glu Gly Lys Leu Glu Arg Glu Lys Lys Asn Gln Lys Met Glu Lys Asp 
                165                 170                 175     


Ser Asp Gly Cys His Leu Lys His Lys Met Glu His Glu Gln Ile Glu 
            180                 185                 190         


Thr Gln Gly Gln Val Asn His Asn Gly Gln Lys Asn Asn Glu Phe Gly 
        195                 200                 205             


Leu Val Glu Asn Tyr Lys Glu Ala Leu Thr Gln Gln Leu Lys Asn Glu 
    210                 215                 220                 


Asp Glu Thr Asp Arg Pro Ser Leu Glu Ser Ala Asn Gly Lys Lys Lys 
225                 230                 235                 240 


Thr Lys Lys Leu Arg Met Lys Arg Asn His Arg Val Glu Pro Leu Asn 
                245                 250                 255     


Ile Asp Asp Cys Ala Pro Glu Ser Pro Thr Pro Pro Pro Pro Pro Pro 
            260                 265                 270         


Pro Val Gly Trp Gly Thr Pro Lys Val Thr Arg Leu Pro Lys Leu Glu 
        275                 280                 285             


Pro Leu Gly Glu Thr His His Asn Asp Phe Tyr Arg Lys Pro Leu Pro 
    290                 295                 300                 


Pro Leu Ala Val Pro Gln Arg Pro Asn Ser Asp Ala His Asp Val Ile 
305                 310                 315                 320 


Ser 
    


<210>  237
<211>  3772
<212>  DNA
<213>  Homosapiens

<400>  237
cttttgggcg gccggacctt agaaagtcac acatctgcgc gcctgtgcgg cccctgcttc     60

tgcggatgct gaggcacgta aaaaaatttg aagaagggaa tttcgcggca ttcttggcct    120

ggcttcctgg cgtagccagc aagttcggag gtgttaaccg ctgctgtcat gtttcttttg    180

ctaaactgca tcgtcgctgt gtcccaaaac atgggcatcg gcaagaacgg ggacctgccc    240

aggccgccgc tcaggaatga attcaggtat ttccagagaa tgaccacaac ttcttcagta    300

gagggtaaac agaatctggt gattatgggt aggaagacct ggttctccat tcctgagaag    360

aatcgacctt taaaggatag aattaattta gttctcagca gagaactaaa ggaacctcca    420

caaggagctc attttcttgc cagaagtttg gatgatgcct taaaacttac tgaacgacca    480

gaattagcaa ataaagtaga catgatttgg atagttggtg gcagttctgt ttataaggaa    540

gccatgaatc acctaggcca tcttaaacta tttgtgacaa ggatcatgca ggactttgaa    600

agtgacacgt ttttttcaga aattgacttg gagaaatata aacttctgcc tgaataccca    660

ggtgttctct ctgatgtcca ggaggggaaa cacatcaagt acaaatttga agtatgtgag    720

aaggatgatt aatatgaagg tgttttctgg tttaagttgt tccccctccc tctgagaaaa    780

gtatgcattt ttacattaga aaagggactt ttgttgactt cagatctatg gataattatt    840

tctaagcaac gtgtttttat tcctcactaa tcttggctat atcagatacc atttatgaaa    900

cattcttgct ataactgtct ctccaagacc ccgactgagt ccccagcacc tgctacagtg    960

agctgccatt ccacacccat cacatgtggc actcttgcca ctccttgaca ttgtcaggct   1020

tttctaatgt tggtagtatt tattaaagat gaagatgcac atacccttca gctgagcagt   1080

ttcactagta ggaaatacca aaagcttcgt acatgtatat ccagaggttt gtagacaaat   1140

gttgcagcct tttttgtaac agtgaaaaac tgaaaacaac ctggaagtcc agtgatggga   1200

aaatgaatat atttctgtct tagattgggg aacccaaagc agattccaag actgaaattt   1260

aagtgaaagc agtttatttg ctaggtcata ccagaagtca tcaatcgaag tatggagaaa   1320

tggaactgag aaggtaaaaa ccagttcaaa atcagtgagg aggttctcaa tggtaacgag   1380

ctccatactg ctgagataca gggaaacgga ggggagaaag ctagagtatt taacccccac   1440

tccttggttg tcagctccct gtcctgtgtg tgggcagaac gtactccacc tactcaatag   1500

caagttccag gtgtttgctg aaagaagctg ctgtaatgta cgggaacggt gaatgccaaa   1560

cacttaaagc aattccatgt ttaagtatgt aaactcttca tacttttttt tttttttctt   1620

tttgggacag agtttcactc ttgttgccca ggcggagtgc agtggaacaa ccttggctca   1680

cggcaacttc agccttccca ggttcaagca attctcctgc ctcaggctcc tgggtggctg   1740

ggactacagg cgcgtgccac cacgccaggc taattttgta tttttggtgg ggacattcca   1800

tgttggtcag gctagtctcg aactcctgac ctcaggtgat cctcctgcct cggccttcag   1860

gggtgctggg attacaggca tcagccactg cacttggcag atcttcattc ttttagtaaa   1920

aagtataaag ccacacatgg tttatttgaa atattttata atttaaaaaa gtacagaagc   1980

aggaaaacca attctaggtt caagtgaggg atgatggtag tttgaaccaa aggattgcat   2040

gtggtaagaa attgtgattt aagatatatt ttaaagttgg aagtagcagg atattctgat   2100

ggagtttgac tttggttttg ggcccactga gtttgagatg cctttgagaa atgaaagaag   2160

tagagagaga attaaaaact ggccaggagt ggtggctcac gcctgtggtc ccagcacttt   2220

ggggggctga ggtgggtgga tcacctgaga ccagcttggg caacatggtg gagccctgtc   2280

tctacagaag atacaaaaat tggctgggcg ttgtggcaca cacctgtagt ctcgtctact   2340

cacggggctg agatggagga ttcaattgag cccatgagtt caaggctgca gtgagtcgtg   2400

attttgccac tgcactcctg cctgggtgac agaagagacc ctgtctcaaa aaagaatctg   2460

aaaacaacgg aaccatgcct tcagaattct ataaagttat tttcaactga taaatctata   2520

ttcaggcaaa gaatcaaggg tgaaggtaaa ataatacatt tttagacaag caaagactca   2580

ggggttacat gtaccctttc ttgggaagct atcggagaaa atactccagc aaaatgaagg   2640

cgtacacaaa ccagagaatg acgtggatcc agcaaatagt atccaacaca ggcaatattc   2700

cagctatgga gctagcttta aaaagaaaca gtaaaaatac taatagatta gctgggtggg   2760

atggcccatg cttgtagtcc cagctactca ggaggctaag caaaaggatg gcttgagccc   2820

aagagttcag agcagcctgg ccaccatagt gagatccctt ctcttaaaaa taataggtta   2880

ttgccagatt tggggcattt agaaagaagt gcattgaaga taaagcaaaa gtaaaaaaaa   2940

aaaaaaacaa aaaaaaacaa gggggaaggg ttggttaggc aataattaat tctagggcag   3000

gaagaagtac aggataggaa gtaagagcat catacgctgt ttttctcaac aatgggcaat   3060

atgtacatag tcataatgat gtggtgactg actgcttagc ccctaaatct ggtaactact   3120

ttgggacaat atggggggaa aagtgaagat agtgatggtg taagagctaa atcctcatct   3180

gtcatatcaa gaaatcacta tataatgtat aacataatca agaaatgact aagtagttat   3240

gtgaagaaaa gaatggaaca ttgctagaag agttagaagt cattgctcca gagaattagg   3300

agggatgggg caggggactg ttaggatgca ttataaactg aagaggcttt taaagattac   3360

atgtattaat atatgtattc acttgaaaaa ctaaaaaaat agtaattttt taaaacccat   3420

ggaggtaact accagaagga aaaactaaga gaatgaaaag tgctttcctc tggaaagaac   3480

aagtcgcagg actgttttca ttgtaagact tttggagcca tttgatttta cttaaccatt   3540

ttcatatatt tctttaataa aaataattct atcttaataa aaagttacac tcattcatta   3600

aaaaaagaat tttaagactg taataagaat catagtttat ttctgttaga gaaaggcaat   3660

gtgttatact tggaaagagg tcatattaat tttatcacat ttttgggact cagcatcttt   3720

atattttctg attttaaata aacaactttg cttacgaaaa aaaaaaaaaa aa           3772


<210>  238
<211>  187
<212>  PRT
<213>  Homosapiens

<400>  238

Met Phe Leu Leu Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Arg Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ala Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Arg Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Ile Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Leu Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Ser Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Gly Lys His Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Cys Glu Lys Asp Asp 
            180                 185         


<210>  239
<211>  1466
<212>  DNA
<213>  Homosapiens

<400>  239
gagaatgaaa gtggatgccc gcgaatcccg gaagtcagac tgtttttttc agttccctgg     60

aggctttttg atactgattc gcgtacacct gttgtttgaa agctctcagc gggacaatgc    120

tgacccagct gaaagcaaaa tcagagggga agcttgcaaa acagatttgc aaagttgtgt    180

tggatcattt tgaaaaacag tattccaaag aactcggaga tgcctggaat acagtaaggg    240

agatactaac atctccatca tgctggcaat atgctgtcct gcttaaccga ttcaattatc    300

cttttgaact ggaaaaggat ttacatttga agggctatca cacactctct cagggatctt    360

tacccaacta tcctaaatca gtgaagtgtt accttagcag aactccgggc cgaatccctt    420

cagaaagaca ccaaattgga aacctgaaaa aatattatct cctaaatgct gcttctcttc    480

tcccagtgtt ggctctggaa ttaagggatg gggagaaggt tctggatctc tgtgctgctc    540

ctggagggaa atcaatagct ctgctgcagt gtgcttgtcc aggttatctt cattgtaatg    600

aatatgatag tctgagattg aggtggctaa ggcagacgtt ggaatctttc atcccacagc    660

ctttgataaa tgtaattaaa gtgtctgaat tggatggcag aaaaatggga gatgcccagc    720

ctgaaatgtt tgacaaggtg ttagtggatg ctccgtgttc aaatgatcga agctggttgt    780

tttcttctga ctctcagaag gcatcctgta ggataagtca aaggaggaat ttgcctcttc    840

tacagataga gctgttaagg tctgcaatta aggccttacg tcctggaggg atacttgtat    900

actctacatg cacgctttcc aaggcagaaa atcaagatgt gatcagtgaa attttaaact    960

cccacggtaa catcatgcct atggacatta aaggaatagc aaggacttgc tcccacgact   1020

tcacatttgc tcccactggc caggaatgtg ggctcttagt gattccagat aagggcaaag   1080

cctggggccc aatgtatgta gccaaattga agaaatcatg gagcacagga aaatggtgac   1140

atgaatttgt aaactgtgtt tatgtgttat tatatttata tttctgaact cagtacatgt   1200

taatatttaa ataattatgc agtaactttc tctgggtctg tttggaatcc tatttagtta   1260

atactttagc atcttagaat ctaggcttga gaattgttca ggtgtatttt tttcctagaa   1320

atatatctgt aacaatgatt taaggtggtg cagatggtgt ttgttctata ttataaatct   1380

gctgtctttg cttggcattt tatagttaaa ttaattagaa tatgtggttt tatgctaaaa   1440

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1466


<210>  240
<211>  340
<212>  PRT
<213>  Homosapiens

<400>  240

Met Leu Thr Gln Leu Lys Ala Lys Ser Glu Gly Lys Leu Ala Lys Gln 
1               5                   10                  15      


Ile Cys Lys Val Val Leu Asp His Phe Glu Lys Gln Tyr Ser Lys Glu 
            20                  25                  30          


Leu Gly Asp Ala Trp Asn Thr Val Arg Glu Ile Leu Thr Ser Pro Ser 
        35                  40                  45              


Cys Trp Gln Tyr Ala Val Leu Leu Asn Arg Phe Asn Tyr Pro Phe Glu 
    50                  55                  60                  


Leu Glu Lys Asp Leu His Leu Lys Gly Tyr His Thr Leu Ser Gln Gly 
65                  70                  75                  80  


Ser Leu Pro Asn Tyr Pro Lys Ser Val Lys Cys Tyr Leu Ser Arg Thr 
                85                  90                  95      


Pro Gly Arg Ile Pro Ser Glu Arg His Gln Ile Gly Asn Leu Lys Lys 
            100                 105                 110         


Tyr Tyr Leu Leu Asn Ala Ala Ser Leu Leu Pro Val Leu Ala Leu Glu 
        115                 120                 125             


Leu Arg Asp Gly Glu Lys Val Leu Asp Leu Cys Ala Ala Pro Gly Gly 
    130                 135                 140                 


Lys Ser Ile Ala Leu Leu Gln Cys Ala Cys Pro Gly Tyr Leu His Cys 
145                 150                 155                 160 


Asn Glu Tyr Asp Ser Leu Arg Leu Arg Trp Leu Arg Gln Thr Leu Glu 
                165                 170                 175     


Ser Phe Ile Pro Gln Pro Leu Ile Asn Val Ile Lys Val Ser Glu Leu 
            180                 185                 190         


Asp Gly Arg Lys Met Gly Asp Ala Gln Pro Glu Met Phe Asp Lys Val 
        195                 200                 205             


Leu Val Asp Ala Pro Cys Ser Asn Asp Arg Ser Trp Leu Phe Ser Ser 
    210                 215                 220                 


Asp Ser Gln Lys Ala Ser Cys Arg Ile Ser Gln Arg Arg Asn Leu Pro 
225                 230                 235                 240 


Leu Leu Gln Ile Glu Leu Leu Arg Ser Ala Ile Lys Ala Leu Arg Pro 
                245                 250                 255     


Gly Gly Ile Leu Val Tyr Ser Thr Cys Thr Leu Ser Lys Ala Glu Asn 
            260                 265                 270         


Gln Asp Val Ile Ser Glu Ile Leu Asn Ser His Gly Asn Ile Met Pro 
        275                 280                 285             


Met Asp Ile Lys Gly Ile Ala Arg Thr Cys Ser His Asp Phe Thr Phe 
    290                 295                 300                 


Ala Pro Thr Gly Gln Glu Cys Gly Leu Leu Val Ile Pro Asp Lys Gly 
305                 310                 315                 320 


Lys Ala Trp Gly Pro Met Tyr Val Ala Lys Leu Lys Lys Ser Trp Ser 
                325                 330                 335     


Thr Gly Lys Trp 
            340 


<210>  241
<211>  7660
<212>  DNA
<213>  Homosapiens

<400>  241
atgatgggac agaatggaga ggagctcttt gcttttaaag gggctccttc agtttcagcc     60

gttcagtggc tgcttctttc agagcaagaa caaggaagga aacgaaactc cctgagagcc    120

ctggacagtc cagatcgagg gctgagtctt ttgttcacac aaactcattt ggcttctaaa    180

cgtcctccac ccaaaatcat tacatccgca gcagcatttc aaaacacagc ccagagtggc    240

ctcgctgagt gggcggctgc ttttctgggg aggctgcagc caccttccca caggccccca    300

aggttcttgc atgtcccaga atatcccgct gctggccacc ggcctgaaat ccccctcatc    360

cggaggaccc ttggtggaag atttgaaact gttactatac ctcttggacc tcagtcctgt    420

gaagggccgt ttctcttctc caccaagaat aagagcaggt tctttgacac ctcgccctcc    480

atgtggcagg tttattccaa attactctcc tactcagggt gtacacagga gaggtgtcgt    540

ggagtggaat tcagcgaggc ccaaactgtt cctgcagcca tttgtctagc ctcagtgctt    600

ttgtcagagt ggattcctag cttccaagag ggcttgggag cctggggcca ctctgatgct    660

gcctggaaac attggccaga aagtaacact gaggcccatg tagaaaacat caccttctat    720

cagaatcaag aggacttttc aacagtgtcc tccaaagagg gcgtgatggt tcagacctct    780

gggaagagcc atgctgcttc ggatgctcca gaaaacctca ctctactcgc tgaaacagca    840

gatgctagag gaaggagcgg ctcttcaagt agaacaaact tcaccatttt gcctgttggg    900

tactcactgg agatagcaac agctctgact tcccagagtg gcaacttagc ctcagaaagt    960

cttcacctgc catccagcag ttcagagttc gatgaaagaa ttgccgcttt tcaaacaaag   1020

agtggaacag cctcggagat gggaacagag agggcgatgg ggctgtcaga agaatggact   1080

gtgcacagcc aagaggccac cacttcggct tggagcccgt cctttcttcc tgctttggag   1140

atgggagagc tgaccacgcc ttctaggaag agaaattcct caggaccaga tctctcctgg   1200

ctgcatttct acaggacagc agcttcctct cctctcttag acctttcctc atcttctgaa   1260

agtacagaga agcttaacaa ctccactggc ctccagagct cctcagtcag tcaaacaaag   1320

acaatgcatg ttgccaccgt gttcactgat ggtggcccga gaacgctgcg atctttgacg   1380

gtcagtctgg gacctgtgag caagacagaa ggcttcccca aggactccag aattgccacg   1440

acttcatcct cagtccttct ttcaccctct gcagtggaat cgagaagaaa cagtagagta   1500

actgggaatc caggggatga ggaattcatt gaaccatcca cagaaaatga atttggactt   1560

acgtctttgc gttggcaaaa tgattcccca acctttggag aacatcagct tgccagcagc   1620

tctgaggtgc aaaatggaag tcccatgtct cagactgaga ctgtgtctag gtcagtcgca   1680

cccatgagag gtggagagat cactgcacac tggctcttga ccaacagcac aacatctgca   1740

gatgtgacag gaagctctgc ttcatatcct gaaggtgtga atgcttcagt gttgacccag   1800

ttctcagact ctactgtaca gtctggagga agtcacacag cattgggaga taggagttat   1860

tcagagtctt catctacatc ttcctcggaa agcttgaatt catcagcacc acgtggagaa   1920

cgttcgatcg ctgggattag ctacggtcaa gtgcgtggca cagctattga acaaaggact   1980

tccagcgacc acacagacca cacctacctg tcatctactt tcaccaaagg agaacgggcg   2040

ttactgtcca ttacagataa cagttcatcc tcagacattg tggagagctc aacttcttat   2100

attaaaatct caaactcttc acattcagag tattcctcct tttttcatgc tcagactgag   2160

agaagtaaca tctcatccta tgacggggaa tatgctcagc cttctactga gtcgccagtt   2220

ctgcatacat ccaaccttcc gtcctacaca cccaccatta atatgccgaa cacttcggtt   2280

gttctggaca ctgatgctga gtttgttagt gactcctcct cctcctcttc ctcctcctcc   2340

tcttcttctt cttcagggcc tcctttgcct ctgccctctg tgtcacaatc ccaccattta   2400

ttttcatcaa ttttaccatc aaccagggcc tctgtgcatc tactaaagtc tacctctgat   2460

gcatccacac catggtcttc ctcaccatca cctttaccag tatccttaac gacatctaca   2520

tctgccccac tttctgtctc acaaacaacc ttgccacagt catcttctac ccctgtcctg   2580

cccagggcaa gggagactcc tgtgacttca tttcagacat caacaatgac atcattcatg   2640

acaatgctcc atagtagtca aactgcagac cttaagagcc agagcacccc acaccaagag   2700

aaagtcatta cagaatcaaa gtcaccaagc ctggtgtctc tgcccacaga gtccaccaaa   2760

gctgtaacaa caaactctcc tttgcctcca tccttaacag agtcctccac agagcaaacc   2820

cttccagcca caagcaccaa cttagcacaa atgtctccaa ctttcacaac taccattctg   2880

aagacctctc agcctcttat gaccactcct ggcaccctgt caagcacagc atctctggtc   2940

actggcccta tagccgtaca gactacagct ggaaaacagc tctcgctgac ccatcctgaa   3000

atactagttc ctcaaatctc aacagaaggt ggcatcagca cagaaaggaa ccgagtgatt   3060

gtggatgcta ccactggatt gatccctttg accagtgtac ccacatcagc aaaagaaatg   3120

accacaaagc ttggcgttac agcagagtac agcccagctt cacgttccct cggaacatct   3180

ccttctcccc aaaccacagt tgtttccacg gctgaagact tggctcccaa atctgccacc   3240

tttgctgttc agagcagcac acagtcacca acaacagtgt cctcttcagc ctcagtcaac   3300

agctgtgctg tgaacccttg tcttcacaat ggcgaatgcg tcgcagacaa caccagccgt   3360

ggctaccact gcaggtgccc gccttcctgg caaggggatg attgcagtgt ggatgtgaat   3420

gagtgcctgt cgaacccctg cccatccaca gccatgtgca acaatactca gggatccttt   3480

atctgcaaat gcccggttgg gtaccagttg gaaaaaggga tatgcaattt ggttagaacc   3540

ttcgtgacag agtttaaatt aaagagaact tttcttaata caactgtgga aaaacattca   3600

gacctacaag aagttgaaaa tgagatcacc aaaacgttaa atatgtgttt ttcagcgtta   3660

cctagttaca tccgatctac agttcacgcc tctagggagt ccaacgcggt ggtgatctca   3720

ctgcaaacaa ccttttccct ggcctccaat gtgacgctat ttgacctggc tgataggatg   3780

cagaaatgtg tcaactcctg caagtcctct gctgaggtct gccagctctt gggatctcag   3840

aggcggatct ttagagcggg cagcttgtgc aagcggaaga gtcccgaatg tgacaaagac   3900

acctccatct gcactgacct ggacggcgtt gccctgtgcc agtgcaagtc gggatacttt   3960

cagttcaaca agatggacca ctcctgccga gcatgtgaag atggatatag gcttgaaaat   4020

gaaacctgca tgagttgccc atttggcctt ggtggtctca actgtggaaa cccctatcag   4080

cttatcactg tggtgatcgc agccgcggga ggtgggctcc tgctcatcct aggcatcgca   4140

ctgattgtta cctgttgcag aaagaataaa aatgacataa gcaaactcat cttcaaaagt   4200

ggagatttcc aaatgtcccc gtatgctgaa taccccaaaa atcctcgctc acaagaatgg   4260

ggccgagaag ctattgaaat gcatgagaat ggaagtacca aaaacctcct ccagatgacg   4320

gatgtgtact actcgcctac aagtgtaagg aatccagaac ttgaacgaaa cggactctac   4380

ccggcctaca ctggactgcc aggatcacgg cattcttgca ttttccccgg acagtataac   4440

ccgtctttca tcagtgatga aagcagaaga agagactact tttaagtcca ggagagagag   4500

ggactcattg ctctgagcca gtcacctggg acctctgctc agaggaccgc accaggaggc   4560

tgcgcccagg atttgtcggg agccacgctg agtggcaagc aggaagaggg acaggcatgc   4620

ggggcgtgac cacagtggag gagacaggtg gatgtggaac cacaggctgc tcattcagca   4680

cctttgttgt tactgtgaac gtgaatgtgg gccagtatca agagagtctc tctgagtgac   4740

tgcaccatgg cactggcacc agggcgacta ttagccaggg cagaccacta gacttcagtg   4800

cagggacctg gttttccctt cgtttgcact ttagtaaatt gggtgggagg tttccttttg   4860

gatctgtttt gagactgttc cagaaagaag gcttcctttc ccgagacact tccataggca   4920

gcaatttggt gattcatttg cagcaaaata ctggcttgtt aattattttc ctgcccagcg   4980

cctgcgtgct aaacaacaga tgaggatgag cgtaccactg aagtctgaag atgtcgccat   5040

tgaacggaca gtgttttcat atgtttctag gttgtcttat gctacagttt ccaagccagc   5100

ccccacagtg aggaaatgtg tgaggcaccg cacacaactg caatgtgttt tttaagtcaa   5160

ggtgacacat gtatttaaga tttttttttt aaatctcttt gcagttaaat ctcacttttt   5220

caaacaagcc tggatcaggg caaaacaact tatatttggt tttagctgga ggctcagcag   5280

gcagattgca ggcagggggg cacttttcat ccatgagggc ccagcctggg gcctgggact   5340

cgatcaccat tgtggaggcc agaggcagct gcgtatggag gagaaatgtc aaactgaacg   5400

caggtttcac cactctagga aagcagcttg ttgagcccct gcagctggat gtggttagag   5460

ggatgggctg aataggcagg ttagatttcc tgcatcaaca gtgctttggg aagctgtgtg   5520

gattcctgag gaagaacagg gagccgagat ggagccacac atgagtttgc tcaccggcta   5580

ctgcagcact ttgtacccag aatctcatgt ccacaaaccc catgtaaact ttcaaccact   5640

caaagctgtt tattcggctg aagaaataac ttttttttct cacccagtca tttgtacctc   5700

ttcatatggc tatgtcgcac cctccagaaa cgtggttata cttccagtca gtgtgggaga   5760

actgaagact tccggttggt cgaggaactg agggttgacc ttcgggaagg aagttccact   5820

catcttattt attatgcctg tgatgtgggt cctgccaggg agacatccag tactcggtgt   5880

ctttaattgc cacctgggga actgtgttta ttggccttct ttggggcatc ctggttttgg   5940

atgaagtgag gggaatacag aggtaaaaga attgtctcca ccctgaagcg gggagtcccg   6000

cttcacattt ctggaaatgg tgcagccact ggggacagtt ctgccccggg catggttgtt   6060

tcttcaaggt cctctaaata taatccctat tcttacataa tccttggccc tgatggtttt   6120

aagcaagaac tcctgtgtcc catggtctcc accactcacc atcaccctgc tgtagcaaga   6180

gtcctagtca ggggaggtgc attttagtag ttacattgca cttatccatg agataaataa   6240

aaggagaact gtttttatca gtggaggcta acctaaaatt tcaaagtgtc gcctttttga   6300

aatcttgggc ctctctctct gtagaaccaa tggccctttg tggctcacgg cctcgcacct   6360

aactggagag ttctgagctc ctgcagctca cctgagccca cagactaggc ttcttggctc   6420

cttccgcagc atgcctgctc acccccagaa cccgcagctg tgggaagagc catgtaggga   6480

ggctattccc aggcatacac ttccactgcc ttcagctgac gtcacagctg acaaatcatc   6540

tcctctatcg gagccagaag acttcagctc cacaaaatga agtgttctgt cctgaaaaca   6600

ttcttgggaa gaatcccaac atcgagaaaa cggtgtcctg tgagttccaa caatgcttct   6660

tgttcatggg tttcttccgt atggagtgga ttaagagtgt tttattttgt tgttctaact   6720

gagaaaaaaa ggaggcaccc acaaggttga ggtcacacag tctccacagt ttccaggagg   6780

cgtttggggg tggggaaggc acctccagag catgaggctc taaggggaca tgagtaaagc   6840

atgtctgtga cccagtgagg aagggagagg ccagctgcac tcctgcacgg ggttcctagc   6900

tgcagaaggg tcccgcctag gccgagggga aacacctgat agcagaagag gcctggatgc   6960

acacctggca cgccgaggct ctccgcccag acacagtgct ccatgtcagc ccctgcacct   7020

ggggtgtgtg attcacgtgc acagatgcca caatcctgca ccaatatccc acagatgggg   7080

gaaggtgaga ggaaggggca agtgatgtgt aactgctcaa gagatgctta aacctccata   7140

gagaggagcc gggcgcaggg gcatctgtgt gtcccgtcac acactgcagc agggaagggt   7200

ggctggctgg ctccctggca tcagtggttt ggtttaagct ccagagggtc ttattgccat   7260

tgtcttttcc tctgcccctt gagccagcct aaggccctgg agtctgtttc tttaggcgga   7320

tgaactgaca tgctcctacc atgaccaggc tctgggcaag gctcctcaca gtatccttga   7380

gaggtgggca tggaagtgcc catttctcag gtacagaaac cttcagagag gataaatagc   7440

ttgccctgta gaagcaggac tgaaaccctt gtctgcctga ctcccccagc tactctgccc   7500

actgtagccc cctgccttac tgtcctggca cacccctcac catcctgtat accttaaata   7560

tcaaagaggg caagagagaa agggctttaa agataagtta tttttttaag gaaccttaat   7620

attattttta agaagtaacc aaattagtga cgtgaaatgc                         7660


<210>  242
<211>  1494
<212>  PRT
<213>  Homosapiens

<400>  242

Met Met Gly Gln Asn Gly Glu Glu Leu Phe Ala Phe Lys Gly Ala Pro 
1               5                   10                  15      


Ser Val Ser Ala Val Gln Trp Leu Leu Leu Ser Glu Gln Glu Gln Gly 
            20                  25                  30          


Arg Lys Arg Asn Ser Leu Arg Ala Leu Asp Ser Pro Asp Arg Gly Leu 
        35                  40                  45              


Ser Leu Leu Phe Thr Gln Thr His Leu Ala Ser Lys Arg Pro Pro Pro 
    50                  55                  60                  


Lys Ile Ile Thr Ser Ala Ala Ala Phe Gln Asn Thr Ala Gln Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Trp Ala Ala Ala Phe Leu Gly Arg Leu Gln Pro Pro Ser 
                85                  90                  95      


His Arg Pro Pro Arg Phe Leu His Val Pro Glu Tyr Pro Ala Ala Gly 
            100                 105                 110         


His Arg Pro Glu Ile Pro Leu Ile Arg Arg Thr Leu Gly Gly Arg Phe 
        115                 120                 125             


Glu Thr Val Thr Ile Pro Leu Gly Pro Gln Ser Cys Glu Gly Pro Phe 
    130                 135                 140                 


Leu Phe Ser Thr Lys Asn Lys Ser Arg Phe Phe Asp Thr Ser Pro Ser 
145                 150                 155                 160 


Met Trp Gln Val Tyr Ser Lys Leu Leu Ser Tyr Ser Gly Cys Thr Gln 
                165                 170                 175     


Glu Arg Cys Arg Gly Val Glu Phe Ser Glu Ala Gln Thr Val Pro Ala 
            180                 185                 190         


Ala Ile Cys Leu Ala Ser Val Leu Leu Ser Glu Trp Ile Pro Ser Phe 
        195                 200                 205             


Gln Glu Gly Leu Gly Ala Trp Gly His Ser Asp Ala Ala Trp Lys His 
    210                 215                 220                 


Trp Pro Glu Ser Asn Thr Glu Ala His Val Glu Asn Ile Thr Phe Tyr 
225                 230                 235                 240 


Gln Asn Gln Glu Asp Phe Ser Thr Val Ser Ser Lys Glu Gly Val Met 
                245                 250                 255     


Val Gln Thr Ser Gly Lys Ser His Ala Ala Ser Asp Ala Pro Glu Asn 
            260                 265                 270         


Leu Thr Leu Leu Ala Glu Thr Ala Asp Ala Arg Gly Arg Ser Gly Ser 
        275                 280                 285             


Ser Ser Arg Thr Asn Phe Thr Ile Leu Pro Val Gly Tyr Ser Leu Glu 
    290                 295                 300                 


Ile Ala Thr Ala Leu Thr Ser Gln Ser Gly Asn Leu Ala Ser Glu Ser 
305                 310                 315                 320 


Leu His Leu Pro Ser Ser Ser Ser Glu Phe Asp Glu Arg Ile Ala Ala 
                325                 330                 335     


Phe Gln Thr Lys Ser Gly Thr Ala Ser Glu Met Gly Thr Glu Arg Ala 
            340                 345                 350         


Met Gly Leu Ser Glu Glu Trp Thr Val His Ser Gln Glu Ala Thr Thr 
        355                 360                 365             


Ser Ala Trp Ser Pro Ser Phe Leu Pro Ala Leu Glu Met Gly Glu Leu 
    370                 375                 380                 


Thr Thr Pro Ser Arg Lys Arg Asn Ser Ser Gly Pro Asp Leu Ser Trp 
385                 390                 395                 400 


Leu His Phe Tyr Arg Thr Ala Ala Ser Ser Pro Leu Leu Asp Leu Ser 
                405                 410                 415     


Ser Ser Ser Glu Ser Thr Glu Lys Leu Asn Asn Ser Thr Gly Leu Gln 
            420                 425                 430         


Ser Ser Ser Val Ser Gln Thr Lys Thr Met His Val Ala Thr Val Phe 
        435                 440                 445             


Thr Asp Gly Gly Pro Arg Thr Leu Arg Ser Leu Thr Val Ser Leu Gly 
    450                 455                 460                 


Pro Val Ser Lys Thr Glu Gly Phe Pro Lys Asp Ser Arg Ile Ala Thr 
465                 470                 475                 480 


Thr Ser Ser Ser Val Leu Leu Ser Pro Ser Ala Val Glu Ser Arg Arg 
                485                 490                 495     


Asn Ser Arg Val Thr Gly Asn Pro Gly Asp Glu Glu Phe Ile Glu Pro 
            500                 505                 510         


Ser Thr Glu Asn Glu Phe Gly Leu Thr Ser Leu Arg Trp Gln Asn Asp 
        515                 520                 525             


Ser Pro Thr Phe Gly Glu His Gln Leu Ala Ser Ser Ser Glu Val Gln 
    530                 535                 540                 


Asn Gly Ser Pro Met Ser Gln Thr Glu Thr Val Ser Arg Ser Val Ala 
545                 550                 555                 560 


Pro Met Arg Gly Gly Glu Ile Thr Ala His Trp Leu Leu Thr Asn Ser 
                565                 570                 575     


Thr Thr Ser Ala Asp Val Thr Gly Ser Ser Ala Ser Tyr Pro Glu Gly 
            580                 585                 590         


Val Asn Ala Ser Val Leu Thr Gln Phe Ser Asp Ser Thr Val Gln Ser 
        595                 600                 605             


Gly Gly Ser His Thr Ala Leu Gly Asp Arg Ser Tyr Ser Glu Ser Ser 
    610                 615                 620                 


Ser Thr Ser Ser Ser Glu Ser Leu Asn Ser Ser Ala Pro Arg Gly Glu 
625                 630                 635                 640 


Arg Ser Ile Ala Gly Ile Ser Tyr Gly Gln Val Arg Gly Thr Ala Ile 
                645                 650                 655     


Glu Gln Arg Thr Ser Ser Asp His Thr Asp His Thr Tyr Leu Ser Ser 
            660                 665                 670         


Thr Phe Thr Lys Gly Glu Arg Ala Leu Leu Ser Ile Thr Asp Asn Ser 
        675                 680                 685             


Ser Ser Ser Asp Ile Val Glu Ser Ser Thr Ser Tyr Ile Lys Ile Ser 
    690                 695                 700                 


Asn Ser Ser His Ser Glu Tyr Ser Ser Phe Phe His Ala Gln Thr Glu 
705                 710                 715                 720 


Arg Ser Asn Ile Ser Ser Tyr Asp Gly Glu Tyr Ala Gln Pro Ser Thr 
                725                 730                 735     


Glu Ser Pro Val Leu His Thr Ser Asn Leu Pro Ser Tyr Thr Pro Thr 
            740                 745                 750         


Ile Asn Met Pro Asn Thr Ser Val Val Leu Asp Thr Asp Ala Glu Phe 
        755                 760                 765             


Val Ser Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    770                 775                 780                 


Ser Gly Pro Pro Leu Pro Leu Pro Ser Val Ser Gln Ser His His Leu 
785                 790                 795                 800 


Phe Ser Ser Ile Leu Pro Ser Thr Arg Ala Ser Val His Leu Leu Lys 
                805                 810                 815     


Ser Thr Ser Asp Ala Ser Thr Pro Trp Ser Ser Ser Pro Ser Pro Leu 
            820                 825                 830         


Pro Val Ser Leu Thr Thr Ser Thr Ser Ala Pro Leu Ser Val Ser Gln 
        835                 840                 845             


Thr Thr Leu Pro Gln Ser Ser Ser Thr Pro Val Leu Pro Arg Ala Arg 
    850                 855                 860                 


Glu Thr Pro Val Thr Ser Phe Gln Thr Ser Thr Met Thr Ser Phe Met 
865                 870                 875                 880 


Thr Met Leu His Ser Ser Gln Thr Ala Asp Leu Lys Ser Gln Ser Thr 
                885                 890                 895     


Pro His Gln Glu Lys Val Ile Thr Glu Ser Lys Ser Pro Ser Leu Val 
            900                 905                 910         


Ser Leu Pro Thr Glu Ser Thr Lys Ala Val Thr Thr Asn Ser Pro Leu 
        915                 920                 925             


Pro Pro Ser Leu Thr Glu Ser Ser Thr Glu Gln Thr Leu Pro Ala Thr 
    930                 935                 940                 


Ser Thr Asn Leu Ala Gln Met Ser Pro Thr Phe Thr Thr Thr Ile Leu 
945                 950                 955                 960 


Lys Thr Ser Gln Pro Leu Met Thr Thr Pro Gly Thr Leu Ser Ser Thr 
                965                 970                 975     


Ala Ser Leu Val Thr Gly Pro Ile Ala Val Gln Thr Thr Ala Gly Lys 
            980                 985                 990         


Gln Leu Ser Leu Thr His Pro Glu  Ile Leu Val Pro Gln  Ile Ser Thr 
        995                 1000                 1005             


Glu Gly  Gly Ile Ser Thr Glu  Arg Asn Arg Val Ile  Val Asp Ala 
    1010                 1015                 1020             


Thr Thr  Gly Leu Ile Pro Leu  Thr Ser Val Pro Thr  Ser Ala Lys 
    1025                 1030                 1035             


Glu Met  Thr Thr Lys Leu Gly  Val Thr Ala Glu Tyr  Ser Pro Ala 
    1040                 1045                 1050             


Ser Arg  Ser Leu Gly Thr Ser  Pro Ser Pro Gln Thr  Thr Val Val 
    1055                 1060                 1065             


Ser Thr  Ala Glu Asp Leu Ala  Pro Lys Ser Ala Thr  Phe Ala Val 
    1070                 1075                 1080             


Gln Ser  Ser Thr Gln Ser Pro  Thr Thr Val Ser Ser  Ser Ala Ser 
    1085                 1090                 1095             


Val Asn  Ser Cys Ala Val Asn  Pro Cys Leu His Asn  Gly Glu Cys 
    1100                 1105                 1110             


Val Ala  Asp Asn Thr Ser Arg  Gly Tyr His Cys Arg  Cys Pro Pro 
    1115                 1120                 1125             


Ser Trp  Gln Gly Asp Asp Cys  Ser Val Asp Val Asn  Glu Cys Leu 
    1130                 1135                 1140             


Ser Asn  Pro Cys Pro Ser Thr  Ala Met Cys Asn Asn  Thr Gln Gly 
    1145                 1150                 1155             


Ser Phe  Ile Cys Lys Cys Pro  Val Gly Tyr Gln Leu  Glu Lys Gly 
    1160                 1165                 1170             


Ile Cys  Asn Leu Val Arg Thr  Phe Val Thr Glu Phe  Lys Leu Lys 
    1175                 1180                 1185             


Arg Thr  Phe Leu Asn Thr Thr  Val Glu Lys His Ser  Asp Leu Gln 
    1190                 1195                 1200             


Glu Val  Glu Asn Glu Ile Thr  Lys Thr Leu Asn Met  Cys Phe Ser 
    1205                 1210                 1215             


Ala Leu  Pro Ser Tyr Ile Arg  Ser Thr Val His Ala  Ser Arg Glu 
    1220                 1225                 1230             


Ser Asn  Ala Val Val Ile Ser  Leu Gln Thr Thr Phe  Ser Leu Ala 
    1235                 1240                 1245             


Ser Asn  Val Thr Leu Phe Asp  Leu Ala Asp Arg Met  Gln Lys Cys 
    1250                 1255                 1260             


Val Asn  Ser Cys Lys Ser Ser  Ala Glu Val Cys Gln  Leu Leu Gly 
    1265                 1270                 1275             


Ser Gln  Arg Arg Ile Phe Arg  Ala Gly Ser Leu Cys  Lys Arg Lys 
    1280                 1285                 1290             


Ser Pro  Glu Cys Asp Lys Asp  Thr Ser Ile Cys Thr  Asp Leu Asp 
    1295                 1300                 1305             


Gly Val  Ala Leu Cys Gln Cys  Lys Ser Gly Tyr Phe  Gln Phe Asn 
    1310                 1315                 1320             


Lys Met  Asp His Ser Cys Arg  Ala Cys Glu Asp Gly  Tyr Arg Leu 
    1325                 1330                 1335             


Glu Asn  Glu Thr Cys Met Ser  Cys Pro Phe Gly Leu  Gly Gly Leu 
    1340                 1345                 1350             


Asn Cys  Gly Asn Pro Tyr Gln  Leu Ile Thr Val Val  Ile Ala Ala 
    1355                 1360                 1365             


Ala Gly  Gly Gly Leu Leu Leu  Ile Leu Gly Ile Ala  Leu Ile Val 
    1370                 1375                 1380             


Thr Cys  Cys Arg Lys Asn Lys  Asn Asp Ile Ser Lys  Leu Ile Phe 
    1385                 1390                 1395             


Lys Ser  Gly Asp Phe Gln Met  Ser Pro Tyr Ala Glu  Tyr Pro Lys 
    1400                 1405                 1410             


Asn Pro  Arg Ser Gln Glu Trp  Gly Arg Glu Ala Ile  Glu Met His 
    1415                 1420                 1425             


Glu Asn  Gly Ser Thr Lys Asn  Leu Leu Gln Met Thr  Asp Val Tyr 
    1430                 1435                 1440             


Tyr Ser  Pro Thr Ser Val Arg  Asn Pro Glu Leu Glu  Arg Asn Gly 
    1445                 1450                 1455             


Leu Tyr  Pro Ala Tyr Thr Gly  Leu Pro Gly Ser Arg  His Ser Cys 
    1460                 1465                 1470             


Ile Phe  Pro Gly Gln Tyr Asn  Pro Ser Phe Ile Ser  Asp Glu Ser 
    1475                 1480                 1485             


Arg Arg  Arg Asp Tyr Phe 
    1490                 


<210>  243
<211>  3482
<212>  DNA
<213>  Homosapiens

<400>  243
gggcgggccg ggcgctggga gctggctgtc ccaggagcag agcagtctcc ctgtccagat     60

caccaggatc cctgcttgct ggagaatgac ccagatgtcc caggtgcagg agctcttcca    120

tgaggcagcc cagcaggatg ccctggccca gccccagccc tggtggaaga cccagctgtt    180

catgtgggag cctgtgctgt ttgggacctg ggatggtgtg ttcacatcct gcatgatcaa    240

catctttggg gttgtgctct tcctgaggac tggctggctg gtgggaaaca caggagtgct    300

cctgggcatg ttcctggtgt ccttcgtcat cctggtggcc ctcgtcacgg tgctgtctgg    360

cattggcgtc ggggagcgca gcagcatcgg cagcggtggc gtctactcca tgatctcctc    420

ggtcctgggt gggcagacgg gaggcaccat cgggctgctc tatgtgtttg gacagtgtgt    480

tgcaggtgcc atgtatatca ccggctttgc tgaatccatc tcggatttgc tgggcctcgg    540

gaatatctgg gctgtgcgag gaatttcagt tgcggtgctt ctggccttgc tgggcattaa    600

cctcgcaggt gtcaaatgga taatccgcct ccagctgctg ttgctgttcc tgctggccgt    660

gtccacactg gactttgtgg tgggttcttt cacccacctg gacccagaac atggtttcat    720

tggatattca cccgaactgc tacagaacaa cacgctgccc gattacagcc cgggggaatc    780

ttttttcact gtctttgggg ttttcttccc agcggctaca ggagtcatgg ccggcttcaa    840

catggggggc gacctcaggg agcctgccgc cagcattccc ctgggctccc tggcagctgt    900

tggcatctcg tggtttctgt acatcgtctt cgtcttcctc ctgggcgcca tctgcactcg    960

agaggccctt cgctatgact tcctgatagc ggaaaaggta tccctcatgg gcttcctgtt   1020

ccttttgggc ttatacatct cgtccctggc ttcctgcatg ggaggacttt atggagctcc   1080

ccgcatcctg cagtgcattg cccaggagaa agtgatccct gcacttgcct gtctgggaca   1140

agggaagggg ccaaacaaaa cacccgtggc tgccatctgc ctgaccagct tggtgaccat   1200

ggcctttgtt tttgtgggtc aagtgaacgt tctggccccc atcgtcacca tcaacttcat   1260

gctgacatac gttgcagtgg actactctta cttctccctg tccatgtgtt cctgcagcct   1320

gaccccggtg cctgagccgg tgctcaggga gggcgcagaa ggcctccact gctctgagca   1380

cctgctctta gagaaagctc ccagttacgg ctctgaggga cctgcccaaa gagtcttgga   1440

gggcacgcta ctggaattca ccaaggacat ggatcagctc ctccagctaa ccaggaagct   1500

tgagagtagc cagcccaggc aaggagaggg taacaggacc ccagaaagtc agaagaggaa   1560

aagcaagaag gccaccaagc agaccctaca agatagcttc ctcttggacc tcaaatcccc   1620

tccttctttc cctgtcgaga tctctgacag gttgcccgct gcctcctggg aggggcagga   1680

gtcctgctgg aacaagcaga cttccaagag cgaagggact cagcctgagg gaacatatgg   1740

agagcaactt gttcctgagc tgtgcaacca atcagagtcc agtggagaag atttcttcct   1800

gaagtccagg ctccaagaac aagatgtctg gagaagatcc acttctttct atacccacat   1860

gtgcaacccc tgggtctccc tgttgggggc tgttgggtcc cttctcatca tgtttgtgat   1920

acagtgggtg tataccctgg ttaacatggg tgttgctgcc atcgtgtatt tctacattgg   1980

ccgggccagt ccagggcttc accttggatc agcctccaac ttcagctttt tccggtggat   2040

gaggtctctc ttgctcccct cctgcaggag cttgcggtcc cctcaggagc agatcatctt   2100

ggcgccgtcc ctggctaagg ttgacatgga gatgactcag ctcacccagg agaatgcaga   2160

cttcgccact cgggatcgct accaccactc ctccctcgtg aaccgggagc agctgatgcc   2220

tcactactag atgcagtgct gggaccttcc tcttttggag ctgtcccatg tacagtggac   2280

ccaagctcag gaccttcgtg gagctgcttc tccaacctga gaaactcaag acccatcctc   2340

ccgctgtcac tttggacaat ggaaatctac attttctttt cccttttttt ttttttttga   2400

gacagagtct cgccctgtca cccaggctgg agtccagtgg cacaatcttg gctcactgca   2460

acctctgctt cccgagttca agcaattctc ctgcctcagc ctcctgagta gctgggatta   2520

taggcatgca ccaccacacc cagctatttt ttgtattttt actggagaca gggtttcacc   2580

atgttggcca ggctggtctc gaactcctga cctcgtgatc cacccgtctc agcctcccaa   2640

agtactggga ttacaggcgt gagccaccat gcctggccag aaatctatgt tttcttagaa   2700

catgtggaag aaggaaaaag acaaaaaagg aaatctggat tctgaggacc acgtctcacc   2760

cagggtgaca tcaggaatgg tgctagcctc tgcaacacga cacccagtct gaagagctct   2820

atacaggtac taagactagc aggggacacc aagactctgc acaaccagat tgcttgtgca   2880

gagggccaca ataagtgtat gttttatatt ttattgtatt atttattcaa aaataaataa   2940

tacactcaca tgtttccaca cccaaaagat atatagagtg aaaagtctcc ctccaatcct   3000

tattctccac ctgctcagtt cctgtctacc ctggcctaga ggtaaccact attctcatcc   3060

gtacatccag catttcttta tggatataca agcaaatggg aatgtagagt ctcacattct   3120

ctctttatac acaaaagtta gcacgttata cacatgttct gcaccttgct tttttccctt   3180

aacaatctat cttggagaca tttcatatca attcatatgc catttgttca tttttttcat   3240

tgtataaatg tgttataatt tatttcgcca gttccacaat gatgagcatt tggattcttt   3300

ccaatctttt gcaatgacaa tcagctctgc agtgaataat cttgtacaaa tgtgcaagca   3360

taaagtgtat ctctaggata aattcccaaa agtggaattg caggatcaaa aggtacatgc   3420

atttgtaaac tattattgtt tagtgagggt ctttttaatt aaagaattaa catgaattgc   3480

ct                                                                  3482


<210>  244
<211>  714
<212>  PRT
<213>  Homosapiens

<400>  244

Met Thr Gln Met Ser Gln Val Gln Glu Leu Phe His Glu Ala Ala Gln 
1               5                   10                  15      


Gln Asp Ala Leu Ala Gln Pro Gln Pro Trp Trp Lys Thr Gln Leu Phe 
            20                  25                  30          


Met Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser 
        35                  40                  45              


Cys Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp 
    50                  55                  60                  


Leu Val Gly Asn Thr Gly Val Leu Leu Gly Met Phe Leu Val Ser Phe 
65                  70                  75                  80  


Val Ile Leu Val Ala Leu Val Thr Val Leu Ser Gly Ile Gly Val Gly 
                85                  90                  95      


Glu Arg Ser Ser Ile Gly Ser Gly Gly Val Tyr Ser Met Ile Ser Ser 
            100                 105                 110         


Val Leu Gly Gly Gln Thr Gly Gly Thr Ile Gly Leu Leu Tyr Val Phe 
        115                 120                 125             


Gly Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser 
    130                 135                 140                 


Ile Ser Asp Leu Leu Gly Leu Gly Asn Ile Trp Ala Val Arg Gly Ile 
145                 150                 155                 160 


Ser Val Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val 
                165                 170                 175     


Lys Trp Ile Ile Arg Leu Gln Leu Leu Leu Leu Phe Leu Leu Ala Val 
            180                 185                 190         


Ser Thr Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu 
        195                 200                 205             


His Gly Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Asn Asn Thr Leu 
    210                 215                 220                 


Pro Asp Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe 
225                 230                 235                 240 


Phe Pro Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp 
                245                 250                 255     


Leu Arg Glu Pro Ala Ala Ser Ile Pro Leu Gly Ser Leu Ala Ala Val 
            260                 265                 270         


Gly Ile Ser Trp Phe Leu Tyr Ile Val Phe Val Phe Leu Leu Gly Ala 
        275                 280                 285             


Ile Cys Thr Arg Glu Ala Leu Arg Tyr Asp Phe Leu Ile Ala Glu Lys 
    290                 295                 300                 


Val Ser Leu Met Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser 
305                 310                 315                 320 


Leu Ala Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln 
                325                 330                 335     


Cys Ile Ala Gln Glu Lys Val Ile Pro Ala Leu Ala Cys Leu Gly Gln 
            340                 345                 350         


Gly Lys Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser 
        355                 360                 365             


Leu Val Thr Met Ala Phe Val Phe Val Gly Gln Val Asn Val Leu Ala 
    370                 375                 380                 


Pro Ile Val Thr Ile Asn Phe Met Leu Thr Tyr Val Ala Val Asp Tyr 
385                 390                 395                 400 


Ser Tyr Phe Ser Leu Ser Met Cys Ser Cys Ser Leu Thr Pro Val Pro 
                405                 410                 415     


Glu Pro Val Leu Arg Glu Gly Ala Glu Gly Leu His Cys Ser Glu His 
            420                 425                 430         


Leu Leu Leu Glu Lys Ala Pro Ser Tyr Gly Ser Glu Gly Pro Ala Gln 
        435                 440                 445             


Arg Val Leu Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln 
    450                 455                 460                 


Leu Leu Gln Leu Thr Arg Lys Leu Glu Ser Ser Gln Pro Arg Gln Gly 
465                 470                 475                 480 


Glu Gly Asn Arg Thr Pro Glu Ser Gln Lys Arg Lys Ser Lys Lys Ala 
                485                 490                 495     


Thr Lys Gln Thr Leu Gln Asp Ser Phe Leu Leu Asp Leu Lys Ser Pro 
            500                 505                 510         


Pro Ser Phe Pro Val Glu Ile Ser Asp Arg Leu Pro Ala Ala Ser Trp 
        515                 520                 525             


Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Thr Ser Lys Ser Glu Gly 
    530                 535                 540                 


Thr Gln Pro Glu Gly Thr Tyr Gly Glu Gln Leu Val Pro Glu Leu Cys 
545                 550                 555                 560 


Asn Gln Ser Glu Ser Ser Gly Glu Asp Phe Phe Leu Lys Ser Arg Leu 
                565                 570                 575     


Gln Glu Gln Asp Val Trp Arg Arg Ser Thr Ser Phe Tyr Thr His Met 
            580                 585                 590         


Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly Ser Leu Leu Ile 
        595                 600                 605             


Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn Met Gly Val Ala 
    610                 615                 620                 


Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro Gly Leu His Leu 
625                 630                 635                 640 


Gly Ser Ala Ser Asn Phe Ser Phe Phe Arg Trp Met Arg Ser Leu Leu 
                645                 650                 655     


Leu Pro Ser Cys Arg Ser Leu Arg Ser Pro Gln Glu Gln Ile Ile Leu 
            660                 665                 670         


Ala Pro Ser Leu Ala Lys Val Asp Met Glu Met Thr Gln Leu Thr Gln 
        675                 680                 685             


Glu Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His His Ser Ser Leu 
    690                 695                 700                 


Val Asn Arg Glu Gln Leu Met Pro His Tyr 
705                 710                 


<210>  245
<211>  3032
<212>  DNA
<213>  Homosapiens

<400>  245
gaattccgga gaaaggcgca ggggtgggag ctgttgccga agctgccaca gcaaaagttc     60

tcccccctcc ccccttcccc tcctctcaag gcccctagaa aggttggagc tgccggccct    120

gcagtcggtg accgctgacg acttcggccg cgcccgcgga tagcgggagg aatcagcagc    180

ttggaaattc aagcacgtga tctggcggga tgggcgtttg cctaacgtat ttaatggagg    240

aatcggatgg cataagtgat taaggtggta ttgaggattt ctgaagccta tgaaaggtag    300

aaactcaacc atgatttctt tttcaactct acagcattcc tttccttgaa gtcttcgttt    360

ttaccttagt ctcgggcagt tatacttaag catgaacatt gacgacaaac tggaaggatt    420

gtttcttaaa tgtggcggca tagacgaaat gcagtcttcc aggacaatgg ttgtaatggg    480

tggagtgtct ggccagtcta ctgtgtctgg agagctacag gattcagtac ttcaagatcg    540

aagtatgcct caccaggaga tccttgctgc agatgaagtg ttacaagaaa gtgaaatgag    600

acaacaggat atgatatcac atgatgaact catggtccat gaggagacag tgaaaaatga    660

tgaagagcag atggaaacac atgaaagact tcctcaagga ctacagtatg cacttaatgt    720

ccctataagc gtaaagcagg aaattacttt tactgatgta tctgagcaac tgatgagaga    780

caaaaaacaa atcagagagc cagtagactt acagaaaaag aagaagcgga aacaacgttc    840

tcccgcaaaa atccttacaa taaatgagga tggatcactt ggtttgaaaa cccctaaatc    900

tcacgtttgt gagcactgca atgctgcctt tagaacgaac tatcacttac agagacatgt    960

cttcattcat acaggtgaaa aaccatttca atgtagtcaa tgtgacatgc gtttcataca   1020

gaagtacctg cttcagagac atgagaagat tcatactggt gaaaaaccat ttcgctgtga   1080

tgaatgtggt atgagattca tacaaaaata tcatatggaa aggcataaga gaactcatag   1140

tggagaaaaa ccttaccagt gtgaatactg tttacagtat ttttccagaa cagatcgtgt   1200

attgaaacat aaacgtatgt gccatgaaaa tcatgacaaa aaactaaata catgtgccat   1260

caaaggtggc cttctgacat ctgaggaaga ttctggcttt tctacatcac caaaagacaa   1320

ctcactgcca aaaaagaaaa ggcagaaaac ggagaaaaaa tcatctggaa tggacaaaga   1380

gagtgctttg gacaaatctg acctgaaaaa agacaaaaat gattacttgc ctgtttattc   1440

ttcaagtact aaagtaaaag atgagtatat ggttgcagaa tatgctgttg aaatgccaca   1500

ttcgtcagtt gggggctcgc atttagaaga tgcgtcagga gaaatacacc cacctaagtt   1560

agttctcaaa aaaattaata gtaagagaag tctgaaacag ccactggagc aaaatcaaac   1620

aatttcacct ttatccacat atgaagagag caaagtttca aagtatgctt ttgaacttgt   1680

ggataaacag gctttactgg actcagaagg caatgctgac attgatcagg ttgataattt   1740

gcaggagggg cccagtaaac ctgtgcatag tagtactaat tatgatgatg ccatgcagtt   1800

tttgaagaag aagcggtatc ttcaagcagc aagtaacaac agcagggaat atgcgctgaa   1860

tgtgggtacc atacgttctc agccttctgt aacacaagca gctgtggcaa gtgtcattga   1920

tgaaagtacc acggcatcca tattagagtc acaggcactg aatgtggaga ttaagagtaa   1980

tcatgacaaa aatgttattc cagatgaggt actgcagact ctgttggatc attattccca   2040

caaagctaat ggacagcatg agatatcctt cagtgttgca gatactgaag tgacttctag   2100

catatcaata aattcttcag aagtaccaga ggtcacccca tcagagaatg ttggatcaag   2160

ctcccaagca tcctcatcag ataaagccaa catgttgcag gaatactcca agtttctgca   2220

gcaggctttg gacagaacta gccaaaatga tgcctatttg aatagcccga gccttaactt   2280

tgtgactgat aaccagaccc tcccaaatca gccagcattc tcttccatag acaagcaggt   2340

ctatgccacc atgcccatca atagctttcg atcaggaatg aattctccac taagaacaac   2400

tccagataag tcccactttg gactaatagt tggtgattca cagcactcat ttcccttttc   2460

aggtgatgag acaaaccatg cttctgccac atcaacacag gactttctgg atcaagtcac   2520

ttctcagaag aaagctgagg cccagcctgt ccaccaagct taccaaatga gctcctttga   2580

acagcccttc cgtgctccct atcatggatc aagagctgga atagctactc aatttagcac   2640

tgccaatgga caggtgaacc ttcggggacc agggacaagt gctgaatttt cagaatttcc   2700

cttggtgaat gtaaatgata atagagctgg gatgacatct tcacctgatg ccacaactgg   2760

ccagactttt ggctaaaaaa aaaaaaaaag tgaaataata ctggcacttt agaacagatt   2820

aatcaagagt ggggttacta tgtgtaaatg gagtgctgta cagatttaag agcaatgcgt   2880

aataacaagt taagctgata tacgatgata ataactgcat ttcgtttggt tagtcagcat   2940

tctttgaact gccttacatg ttgtcacctt tatagaagca atgcattact tgttttagat   3000

cagaaacttg ctattccacc cacaccaagt aa                                 3032


<210>  246
<211>  794
<212>  PRT
<213>  Homosapiens

<400>  246

Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Thr Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Val Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Arg Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 


<210>  247
<211>  3150
<212>  DNA
<213>  Homosapiens

<400>  247
ccgagccggg cgcgcagcga cggagctggg gccggcctgg gaccatgggc gtgagtgcaa     60

tctacggatc agtctctgat ggtgggtcgt taacctcagt ggggactcca agatttccat    120

gaagaaaatc agttgtcttc attcaagaat tggggtctgg ctcagaattc ctgcagctgg    180

tgaaaatctg ttttctagaa gaggtttaat taatgcctgc agtctgacat gttcccgatt    240

tgaggtgaaa ccatgaagag aaaatagaat acttaataat gcttttccgc aaccgcttct    300

tgctgctgct ggccctggct gcgctgctgg cctttgtgag cctcagcctg cagttcttcc    360

acctgatccc ggtgtcgact cctaagaatg gaatgagtag caagagtcga aagagaatca    420

tgcccgaccc tgtgacggag ccccctgtga cagaccccgt ttatgaagct cttttgtact    480

gcaacatccc cagtgtggcc gagcgcagca tggaaggtca tgccccgcat cattttaagc    540

tggtctcagt gcatgtgttc attcgccacg gagacaggta cccactgtat gtcattccca    600

aaacaaagcg accagaaatt gactgcactc tggtggctaa caggaaaccg tatcacccaa    660

aactggaagc tttcattagt cacatgtcaa aaggatccgg agcctctttc gaaagcccct    720

tgaactcctt gcctctttac ccaaatcacc cattgtgtga gatgggagag ctcacacaga    780

caggagttgt gcagcatttg cagaacggtc agctgctgag ggatatctat ctaaagaaac    840

acaaactcct gcccaatgat tggtctgcag accagctcta tttagagacc actgggaaaa    900

gccggaccct acaaagtggg ctggccttgc tttatggctt tctcccagat tttgactgga    960

agaagattta tttcaggcac cagccaagtg cgctgttctg ctctggaagc tgctattgcc   1020

cggtaagaaa ccagtatctg gaaaaggagc agcgtcgtca gtacctccta cgtttgaaaa   1080

acagccagct ggagaagacc tacggggaga tggccaagat cgtggatgtc cccaccaagc   1140

agcttagagc tgccaacccc atagactcca tgctctgcca cttctgccac aatgtcagct   1200

ttccctgtac cagaaatggc tgtgttgaca tggagcactt caaggtaatt aagacccatc   1260

agatcgagga tgaaagggaa agacgggaga agaaattgta cttcgggtat tctctcctgg   1320

gtgcccaccc catcctgaac caaaccatcg gccggatgca gcgtgccacc gagggcagga   1380

aagaagagct ctttgccctc tactctgctc atgatgtcac tctgtcacca gttctcagtg   1440

ccttgggcct ttcagaagcc aggttcccaa ggtttgcagc caggttgatc tttgagcttt   1500

ggcaagacag agaaaagccc agtgaacatt ccgtccggat tctttacaat ggcgtcgatg   1560

tcacattcca cacctctttc tgccaagacc accacaagcg ttctcccaag cccatgtgcc   1620

cgcttgaaaa cttggtccgc tttgtgaaaa gggacatgtt tgtagccctg ggtggcagtg   1680

gtacaaatta ttatgatgca tgtcacaggg aaggattcta aaaggtatgc agtacagcag   1740

tatagaatcc atgccaatac agagcatagg gaaaggtcca cttctagttt tgtctgttac   1800

taagggtaga agattattgc tttttaaagg ctaaatattg tttgtgggaa ccacagatgg   1860

ttggggttga acagtaagca cattgctgca atgtggtacg tgaattgctt ggtacaaaat   1920

ggccagttca cagaggaata gaaggtactt tatcatagcc agacttcgct tagaatgcca   1980

gaataatata gttcaagacc tgaagttgcc aatccaagtt tgcactcttc tggcctgccc   2040

catgttacta tgtgatggaa ccagcacacc tcaaccaaaa tttttttaat cttagacatt   2100

tttaccttgt ccttgttaag aatttcttga agtgatttat ctaaaataaa ggttggcaaa   2160

ctttttctgt aaagggccag attgtaaata tttcagactg tgtggaccaa aaggccacat   2220

acagtctctg tcataactac tcaactctgt ttctgaagca ggaaagccac cacagacagt   2280

acataaagga atatgtgtag ctgggttccc aggccagaca aaacagatgg tgaccagact   2340

tggcccctgg gctgtagttt gctgacccct catctaaaaa ataggctata ctacaattgc   2400

acttccagca ctttgagaac gagttgaata ccaagaatta ttcaatggtt cctccagtaa   2460

cttctgctag aaacacagaa tttggtctgt atctgacact agaacaaaac ttgagggtaa   2520

ataaacattg aattagaatg aatcatagaa aactgattag aagaatactt gatgtttatg   2580

atgattgtgg tacaagatag ttttaagtat gttctaaata tttgtctgct gtagtctatt   2640

tgctgtatat gctgaaattt ttgtatgcca tttagtattt ttatagttta ggaaaatatt   2700

ttctaagacc agttttagat gactcttatt cctgtagtaa tattcaattt gctgtacctg   2760

cttggtggtt agaaggaggc tagaagatga attcaggcac tttcttccaa taaaactaat   2820

tatggctcat tccctttgac aagctgtaga actggattca tttttaaacc attttcatca   2880

gtttcaaatg gtaaattctg attgattttt aaatgcgttt ttggaagaac tttgctatta   2940

ggtagtttac agatctttat aaggtgtttt atatattaga agcaattata attacatctg   3000

tgatttctga actaatggtg ctaattcaga gaaatggaaa gtgaaagtga gattctctgt   3060

tgtcatcggc attccaactt tttctctttg tttttgtcca gtgttgcatt tgaatatgtc   3120

tgtttctata aataaatttt ttaagaataa                                    3150


<210>  248
<211>  480
<212>  PRT
<213>  Homosapiens

<400>  248

Met Leu Phe Arg Asn Arg Phe Leu Leu Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Ala Phe Val Ser Leu Ser Leu Gln Phe Phe His Leu Ile Pro Val 
            20                  25                  30          


Ser Thr Pro Lys Asn Gly Met Ser Ser Lys Ser Arg Lys Arg Ile Met 
        35                  40                  45              


Pro Asp Pro Val Thr Glu Pro Pro Val Thr Asp Pro Val Tyr Glu Ala 
    50                  55                  60                  


Leu Leu Tyr Cys Asn Ile Pro Ser Val Ala Glu Arg Ser Met Glu Gly 
65                  70                  75                  80  


His Ala Pro His His Phe Lys Leu Val Ser Val His Val Phe Ile Arg 
                85                  90                  95      


His Gly Asp Arg Tyr Pro Leu Tyr Val Ile Pro Lys Thr Lys Arg Pro 
            100                 105                 110         


Glu Ile Asp Cys Thr Leu Val Ala Asn Arg Lys Pro Tyr His Pro Lys 
        115                 120                 125             


Leu Glu Ala Phe Ile Ser His Met Ser Lys Gly Ser Gly Ala Ser Phe 
    130                 135                 140                 


Glu Ser Pro Leu Asn Ser Leu Pro Leu Tyr Pro Asn His Pro Leu Cys 
145                 150                 155                 160 


Glu Met Gly Glu Leu Thr Gln Thr Gly Val Val Gln His Leu Gln Asn 
                165                 170                 175     


Gly Gln Leu Leu Arg Asp Ile Tyr Leu Lys Lys His Lys Leu Leu Pro 
            180                 185                 190         


Asn Asp Trp Ser Ala Asp Gln Leu Tyr Leu Glu Thr Thr Gly Lys Ser 
        195                 200                 205             


Arg Thr Leu Gln Ser Gly Leu Ala Leu Leu Tyr Gly Phe Leu Pro Asp 
    210                 215                 220                 


Phe Asp Trp Lys Lys Ile Tyr Phe Arg His Gln Pro Ser Ala Leu Phe 
225                 230                 235                 240 


Cys Ser Gly Ser Cys Tyr Cys Pro Val Arg Asn Gln Tyr Leu Glu Lys 
                245                 250                 255     


Glu Gln Arg Arg Gln Tyr Leu Leu Arg Leu Lys Asn Ser Gln Leu Glu 
            260                 265                 270         


Lys Thr Tyr Gly Glu Met Ala Lys Ile Val Asp Val Pro Thr Lys Gln 
        275                 280                 285             


Leu Arg Ala Ala Asn Pro Ile Asp Ser Met Leu Cys His Phe Cys His 
    290                 295                 300                 


Asn Val Ser Phe Pro Cys Thr Arg Asn Gly Cys Val Asp Met Glu His 
305                 310                 315                 320 


Phe Lys Val Ile Lys Thr His Gln Ile Glu Asp Glu Arg Glu Arg Arg 
                325                 330                 335     


Glu Lys Lys Leu Tyr Phe Gly Tyr Ser Leu Leu Gly Ala His Pro Ile 
            340                 345                 350         


Leu Asn Gln Thr Ile Gly Arg Met Gln Arg Ala Thr Glu Gly Arg Lys 
        355                 360                 365             


Glu Glu Leu Phe Ala Leu Tyr Ser Ala His Asp Val Thr Leu Ser Pro 
    370                 375                 380                 


Val Leu Ser Ala Leu Gly Leu Ser Glu Ala Arg Phe Pro Arg Phe Ala 
385                 390                 395                 400 


Ala Arg Leu Ile Phe Glu Leu Trp Gln Asp Arg Glu Lys Pro Ser Glu 
                405                 410                 415     


His Ser Val Arg Ile Leu Tyr Asn Gly Val Asp Val Thr Phe His Thr 
            420                 425                 430         


Ser Phe Cys Gln Asp His His Lys Arg Ser Pro Lys Pro Met Cys Pro 
        435                 440                 445             


Leu Glu Asn Leu Val Arg Phe Val Lys Arg Asp Met Phe Val Ala Leu 
    450                 455                 460                 


Gly Gly Ser Gly Thr Asn Tyr Tyr Asp Ala Cys His Arg Glu Gly Phe 
465                 470                 475                 480 


<210>  249
<211>  3922
<212>  DNA
<213>  Homosapiens

<400>  249
aggctgccca gaggggctcc agcataagca ggagacatgg agactcttgc ctccatcatg     60

gaggaggttc acaccagaag ccagctctgc ccttggagac tctcttcccc cagtgctccc    120

ctgaagcttc acactcacca gtctcatgct gcaccctgac cggcaggtcc ctagcatgag    180

ccccataatc cctggggact gcattatcac agaccagtaa taagaagatg acagtcatgt    240

ccctttccag ggacctcaag gacgactttc acagtgacac ggtactctcc atcttaaatg    300

agcagcgcat tcggggcatt ttatgcgatg tcactatcat tgtggaagat accaaattta    360

aagcccatag caatgttctg gcagcttcaa gcctgtattt taaaaatatc ttttggagcc    420

atacaatctg tatttccagc cacgtcctgg agctggacga tctcaaagct gaagtgttta    480

ctgaaatact taattatatc tacagttcca cagtcgttgt caagagacag gaaacagtca    540

ctgatctcgc agctgcagga aaaaagctgg gaatatcgtt cttggaagac cttactgatc    600

gcaacttctc aaattccccg ggtccctatg tattctgtat tactgaaaag ggagtggtta    660

aagaagaaaa aaatgaaaaa aggcatgaag aaccagccat cactaatggg ccaaggatca    720

caaatgcatt ttccatcatc gaaacagaaa atagtaataa catgttttcc ccgctggact    780

tgagggcaag tttcaaaaag gtctccgact ccatgagaac agctagcctt tgcctggaga    840

ggacggacgt ctgccacgag gcagagcctg tccgcacact tgccgagcac tcatacgctg    900

tttcttccgt agctgaagct tacagaagtc agcctgtacg tgaacatgat ggcagttcac    960

ctggtaacac agggaaagaa aattgtgaag cccttgcagc gaaaccgaaa acatgccgga   1020

agccaaagac attctccata ccacaggatt cggattcagc cacagaaaat ataccacccc   1080

ctccagtatc caacttagag gttaatcaag aaagaagtcc acaaccagct gctgttctca   1140

ctcgttcaaa atctccaaac aatgaaggag atgtccattt ttccagggaa gatgaaaatc   1200

aatcttctga tgttcccggg ccgccagccg cagaggttcc acctctggtg tacaattgta   1260

gctgctgttc caaagccttt gacagcagca ctctgctcag tgcccacatg cagcttcaca   1320

agccaaccca ggagccttta gtgtgcaagt attgcaacaa acaattcacc accctgaaca   1380

ggttggatcg gcatgaacag atctgcatga ggtcaagcca catgcccatt cctggaggaa   1440

accaacgctt tttagaaaac tatcctacca ttggacaaaa tggaggttca ttcacaggtc   1500

cagaaccttt attatctgaa aataggattg gtgaattttc cagtaccgga agtactttgc   1560

cagacacgga ccacatggtt aaatttgtta atgggcaaat gctctacagt tgcgttgtgt   1620

gcaaacgtag ttatgtgacc ttatctagcc tccgaagaca tgcaaatgtt cactcctgga   1680

gaagaacata tccttgccat tactgcaaca aagtatttgc attggctgag tacaggacaa   1740

ggcatgaaat ttggcatacg ggagaaagac gatatcagtg cattttctgt cttgaaactt   1800

tcatgaccta ctatatactc aaaaatcatc agaagtcttt ccatgccatc gatcatagac   1860

tttccatcag taaaaaaaca gcaaatggag gcttgaagcc tagtgtctat ccgtataaac   1920

tttataggct actgcctatg aaatgcaaga gagcccctta taagagctac cgaaattctt   1980

cctatgaaaa tgcacgagaa aacagtcaaa tgaatgagtc tgcacctggt acctatgttg   2040

ttcagaatcc acacagctct gaattaccaa cgctgaattt ccaagatact gtaaacaccc   2100

tgaccaacag tccagccatc ccattggaaa catctgcatg tcaggacata cccacttctg   2160

ccaatgtaca aaatgcagag ggtaccaaat ggggagagga ggcattgaaa atggatcttg   2220

acaataactt ttattcaact gaggtgtcag tttcttccac tgaaaatgct gtcagttctg   2280

acctccgggc aggggatgta cctgttttat ctttgagtaa tagcagtgag aatgccgcct   2340

ctgtgatcag ctacagtggc tctgcaccct cggtcattgt acacagcagc cagttttcat   2400

cggtgatcat gcacagcaat gccattgctg ccatgaccag cagcaaccac agagcctttt   2460

cagacccagc tgtcagtcag tccctgaaag atgacagtaa gcccgagcca gataaagtgg   2520

gtaggtttgc aagcagaccc aaaagcatta aggagaaaaa gaaaactaca tcacatacca   2580

ggggagaaat accggaggag tcaaactatg ttgctgatcc tggaggatca ctgagcaaaa   2640

ccacaaatat tgctgaagaa accagcaaaa ttgaaaccta cattgcaaaa cctgctctgc   2700

cgggaacctc cacaaatagt aatgttgcac ccctttgcca aataacagtg aaaattggaa   2760

acgaagccat tgtgaaaagg cacattctag gatctaaatt gttttataaa agagggagaa   2820

gacccaagta tcagatgcag gaggagcctt tgccacaggg gaatgaccca gaacccagtg   2880

gagacagccc actcgggctt tgccaatccg agtgcatgga gatgagtgaa gtgttcgatg   2940

acgcaagtga ccaggattcc actgacaaac cgtggcgccc ttactacaac tacaaaccca   3000

aaaagaaatc cagacagttg aaaaaaatga ggaaagtcaa ctggaggaag gagcacggaa   3060

acaggagccc gagccataaa tgtaaatacc cagcagaact ggattgcgcc gtggggaagg   3120

ctcctcagga taaacccttt gaggaagaag aaactaaaga gatgcccaag ctgcagtgtg   3180

aactctgtga tggagacaaa gcagtggggg ctggaaacca aggaaggccc caccgacatc   3240

ttacttctcg gccatatgcc tgcgagctct gcgccaagca gttccagagc ccttccacac   3300

tcaaaatgca catgagatgt cacaccgggg agaagccata ccagtgcaag acctgcggac   3360

ggtgcttttc ggtgcaagga aacttacaga aacatgaacg catccacctg ggcttgaagg   3420

agttcgtctg tcagtattgc aacaaggcat tcaccttgaa tgagaccctc aaaatccatg   3480

aaagaatcca tactggagaa aagcgttacc actgtcagtt ctgctttcag agatttttgt   3540

atctctccac caaaaggaat cacgagcaga ggcatattcg ggagcataat gggaagggct   3600

atgcctgctt ccagtgcccc aaaatttgca aaacagctgc tgcccttgga atgcaccaaa   3660

agaaacactt attcaaaagc ccaagtcagc aggagaaaat aggtgacgtg tgccacgaaa   3720

actcaaatcc cttggagaat caacatttca ttggttcaga agacaatgac caaaaggata   3780

acatacaaac cggtgtggaa aatgttgtcc tttgagtggc aagaattaga aaaatcttca   3840

aaaatatagt tggtggtttt tttagttatg atttaagttt agtttcattt tgtccatgtg   3900

acagtcatga aggagtgaaa tt                                            3922


<210>  250
<211>  1195
<212>  PRT
<213>  Homosapiens

<400>  250

Met Thr Val Met Ser Leu Ser Arg Asp Leu Lys Asp Asp Phe His Ser 
1               5                   10                  15      


Asp Thr Val Leu Ser Ile Leu Asn Glu Gln Arg Ile Arg Gly Ile Leu 
            20                  25                  30          


Cys Asp Val Thr Ile Ile Val Glu Asp Thr Lys Phe Lys Ala His Ser 
        35                  40                  45              


Asn Val Leu Ala Ala Ser Ser Leu Tyr Phe Lys Asn Ile Phe Trp Ser 
    50                  55                  60                  


His Thr Ile Cys Ile Ser Ser His Val Leu Glu Leu Asp Asp Leu Lys 
65                  70                  75                  80  


Ala Glu Val Phe Thr Glu Ile Leu Asn Tyr Ile Tyr Ser Ser Thr Val 
                85                  90                  95      


Val Val Lys Arg Gln Glu Thr Val Thr Asp Leu Ala Ala Ala Gly Lys 
            100                 105                 110         


Lys Leu Gly Ile Ser Phe Leu Glu Asp Leu Thr Asp Arg Asn Phe Ser 
        115                 120                 125             


Asn Ser Pro Gly Pro Tyr Val Phe Cys Ile Thr Glu Lys Gly Val Val 
    130                 135                 140                 


Lys Glu Glu Lys Asn Glu Lys Arg His Glu Glu Pro Ala Ile Thr Asn 
145                 150                 155                 160 


Gly Pro Arg Ile Thr Asn Ala Phe Ser Ile Ile Glu Thr Glu Asn Ser 
                165                 170                 175     


Asn Asn Met Phe Ser Pro Leu Asp Leu Arg Ala Ser Phe Lys Lys Val 
            180                 185                 190         


Ser Asp Ser Met Arg Thr Ala Ser Leu Cys Leu Glu Arg Thr Asp Val 
        195                 200                 205             


Cys His Glu Ala Glu Pro Val Arg Thr Leu Ala Glu His Ser Tyr Ala 
    210                 215                 220                 


Val Ser Ser Val Ala Glu Ala Tyr Arg Ser Gln Pro Val Arg Glu His 
225                 230                 235                 240 


Asp Gly Ser Ser Pro Gly Asn Thr Gly Lys Glu Asn Cys Glu Ala Leu 
                245                 250                 255     


Ala Ala Lys Pro Lys Thr Cys Arg Lys Pro Lys Thr Phe Ser Ile Pro 
            260                 265                 270         


Gln Asp Ser Asp Ser Ala Thr Glu Asn Ile Pro Pro Pro Pro Val Ser 
        275                 280                 285             


Asn Leu Glu Val Asn Gln Glu Arg Ser Pro Gln Pro Ala Ala Val Leu 
    290                 295                 300                 


Thr Arg Ser Lys Ser Pro Asn Asn Glu Gly Asp Val His Phe Ser Arg 
305                 310                 315                 320 


Glu Asp Glu Asn Gln Ser Ser Asp Val Pro Gly Pro Pro Ala Ala Glu 
                325                 330                 335     


Val Pro Pro Leu Val Tyr Asn Cys Ser Cys Cys Ser Lys Ala Phe Asp 
            340                 345                 350         


Ser Ser Thr Leu Leu Ser Ala His Met Gln Leu His Lys Pro Thr Gln 
        355                 360                 365             


Glu Pro Leu Val Cys Lys Tyr Cys Asn Lys Gln Phe Thr Thr Leu Asn 
    370                 375                 380                 


Arg Leu Asp Arg His Glu Gln Ile Cys Met Arg Ser Ser His Met Pro 
385                 390                 395                 400 


Ile Pro Gly Gly Asn Gln Arg Phe Leu Glu Asn Tyr Pro Thr Ile Gly 
                405                 410                 415     


Gln Asn Gly Gly Ser Phe Thr Gly Pro Glu Pro Leu Leu Ser Glu Asn 
            420                 425                 430         


Arg Ile Gly Glu Phe Ser Ser Thr Gly Ser Thr Leu Pro Asp Thr Asp 
        435                 440                 445             


His Met Val Lys Phe Val Asn Gly Gln Met Leu Tyr Ser Cys Val Val 
    450                 455                 460                 


Cys Lys Arg Ser Tyr Val Thr Leu Ser Ser Leu Arg Arg His Ala Asn 
465                 470                 475                 480 


Val His Ser Trp Arg Arg Thr Tyr Pro Cys His Tyr Cys Asn Lys Val 
                485                 490                 495     


Phe Ala Leu Ala Glu Tyr Arg Thr Arg His Glu Ile Trp His Thr Gly 
            500                 505                 510         


Glu Arg Arg Tyr Gln Cys Ile Phe Cys Leu Glu Thr Phe Met Thr Tyr 
        515                 520                 525             


Tyr Ile Leu Lys Asn His Gln Lys Ser Phe His Ala Ile Asp His Arg 
    530                 535                 540                 


Leu Ser Ile Ser Lys Lys Thr Ala Asn Gly Gly Leu Lys Pro Ser Val 
545                 550                 555                 560 


Tyr Pro Tyr Lys Leu Tyr Arg Leu Leu Pro Met Lys Cys Lys Arg Ala 
                565                 570                 575     


Pro Tyr Lys Ser Tyr Arg Asn Ser Ser Tyr Glu Asn Ala Arg Glu Asn 
            580                 585                 590         


Ser Gln Met Asn Glu Ser Ala Pro Gly Thr Tyr Val Val Gln Asn Pro 
        595                 600                 605             


His Ser Ser Glu Leu Pro Thr Leu Asn Phe Gln Asp Thr Val Asn Thr 
    610                 615                 620                 


Leu Thr Asn Ser Pro Ala Ile Pro Leu Glu Thr Ser Ala Cys Gln Asp 
625                 630                 635                 640 


Ile Pro Thr Ser Ala Asn Val Gln Asn Ala Glu Gly Thr Lys Trp Gly 
                645                 650                 655     


Glu Glu Ala Leu Lys Met Asp Leu Asp Asn Asn Phe Tyr Ser Thr Glu 
            660                 665                 670         


Val Ser Val Ser Ser Thr Glu Asn Ala Val Ser Ser Asp Leu Arg Ala 
        675                 680                 685             


Gly Asp Val Pro Val Leu Ser Leu Ser Asn Ser Ser Glu Asn Ala Ala 
    690                 695                 700                 


Ser Val Ile Ser Tyr Ser Gly Ser Ala Pro Ser Val Ile Val His Ser 
705                 710                 715                 720 


Ser Gln Phe Ser Ser Val Ile Met His Ser Asn Ala Ile Ala Ala Met 
                725                 730                 735     


Thr Ser Ser Asn His Arg Ala Phe Ser Asp Pro Ala Val Ser Gln Ser 
            740                 745                 750         


Leu Lys Asp Asp Ser Lys Pro Glu Pro Asp Lys Val Gly Arg Phe Ala 
        755                 760                 765             


Ser Arg Pro Lys Ser Ile Lys Glu Lys Lys Lys Thr Thr Ser His Thr 
    770                 775                 780                 


Arg Gly Glu Ile Pro Glu Glu Ser Asn Tyr Val Ala Asp Pro Gly Gly 
785                 790                 795                 800 


Ser Leu Ser Lys Thr Thr Asn Ile Ala Glu Glu Thr Ser Lys Ile Glu 
                805                 810                 815     


Thr Tyr Ile Ala Lys Pro Ala Leu Pro Gly Thr Ser Thr Asn Ser Asn 
            820                 825                 830         


Val Ala Pro Leu Cys Gln Ile Thr Val Lys Ile Gly Asn Glu Ala Ile 
        835                 840                 845             


Val Lys Arg His Ile Leu Gly Ser Lys Leu Phe Tyr Lys Arg Gly Arg 
    850                 855                 860                 


Arg Pro Lys Tyr Gln Met Gln Glu Glu Pro Leu Pro Gln Gly Asn Asp 
865                 870                 875                 880 


Pro Glu Pro Ser Gly Asp Ser Pro Leu Gly Leu Cys Gln Ser Glu Cys 
                885                 890                 895     


Met Glu Met Ser Glu Val Phe Asp Asp Ala Ser Asp Gln Asp Ser Thr 
            900                 905                 910         


Asp Lys Pro Trp Arg Pro Tyr Tyr Asn Tyr Lys Pro Lys Lys Lys Ser 
        915                 920                 925             


Arg Gln Leu Lys Lys Met Arg Lys Val Asn Trp Arg Lys Glu His Gly 
    930                 935                 940                 


Asn Arg Ser Pro Ser His Lys Cys Lys Tyr Pro Ala Glu Leu Asp Cys 
945                 950                 955                 960 


Ala Val Gly Lys Ala Pro Gln Asp Lys Pro Phe Glu Glu Glu Glu Thr 
                965                 970                 975     


Lys Glu Met Pro Lys Leu Gln Cys Glu Leu Cys Asp Gly Asp Lys Ala 
            980                 985                 990         


Val Gly Ala Gly Asn Gln Gly Arg  Pro His Arg His Leu  Thr Ser Arg 
        995                 1000                 1005             


Pro Tyr  Ala Cys Glu Leu Cys  Ala Lys Gln Phe Gln  Ser Pro Ser 
    1010                 1015                 1020             


Thr Leu  Lys Met His Met Arg  Cys His Thr Gly Glu  Lys Pro Tyr 
    1025                 1030                 1035             


Gln Cys  Lys Thr Cys Gly Arg  Cys Phe Ser Val Gln  Gly Asn Leu 
    1040                 1045                 1050             


Gln Lys  His Glu Arg Ile His  Leu Gly Leu Lys Glu  Phe Val Cys 
    1055                 1060                 1065             


Gln Tyr  Cys Asn Lys Ala Phe  Thr Leu Asn Glu Thr  Leu Lys Ile 
    1070                 1075                 1080             


His Glu  Arg Ile His Thr Gly  Glu Lys Arg Tyr His  Cys Gln Phe 
    1085                 1090                 1095             


Cys Phe  Gln Arg Phe Leu Tyr  Leu Ser Thr Lys Arg  Asn His Glu 
    1100                 1105                 1110             


Gln Arg  His Ile Arg Glu His  Asn Gly Lys Gly Tyr  Ala Cys Phe 
    1115                 1120                 1125             


Gln Cys  Pro Lys Ile Cys Lys  Thr Ala Ala Ala Leu  Gly Met His 
    1130                 1135                 1140             


Gln Lys  Lys His Leu Phe Lys  Ser Pro Ser Gln Gln  Glu Lys Ile 
    1145                 1150                 1155             


Gly Asp  Val Cys His Glu Asn  Ser Asn Pro Leu Glu  Asn Gln His 
    1160                 1165                 1170             


Phe Ile  Gly Ser Glu Asp Asn  Asp Gln Lys Asp Asn  Ile Gln Thr 
    1175                 1180                 1185             


Gly Val  Glu Asn Val Val Leu  
    1190                 1195 


<210>  251
<211>  2592
<212>  DNA
<213>  Homosapiens

<400>  251
atggcggcgg cggcgcctgc tgctgcggcg gcttcttccg aggcgccagc ggcgagtgcg     60

actgcagagc ccgaggccgg ggaccaggac agtcgcgagg ttcgagtgtt gcagagcctg    120

cggggcaaga tctgtgaagc aaaaaattta ttgccatatc ttggacccca caaaatgaga    180

gattgtttct gtaccataaa tttggaccag gaagaagttt atcgtaccca agttgtggaa    240

aaatctttaa gcccattttt cagtgaagaa ttttactttg agattccaag aactttccag    300

tatttgtctt tctatgttta tgataagaat gttttacaaa gagatctccg tataggaaaa    360

gtagccatca aaaaagaaga cttgtgtaat cacagtggca aagaaacttg gttttcatta    420

cagcctgttg actccaattc agaggttcag ggtaaagttc accttgaatt aaaactgaat    480

gaactgataa cggagaatgg aactgtatgc cagcagcttg ttgtacacat caaggcatgc    540

catgggttgc ctctcataaa tggccaaagc tgtgaccctt atgcaacagt ttctctagtg    600

ggcccttcta ggaatgacca aaagaagaca aaagtaaaga agaaaacaag caatccgcag    660

tttaatgaaa tcttttattt tgaagtaacc agatccagta gttacaccag aaagtcccag    720

ttccaggtag aagaggagga cattgaaaag ctagaaatca ggatcgactt gtggaacaat    780

ggaaacctag tccaagatgt tttcctaggt gagattaagg ttcctgtgaa cgtattaaga    840

actgattcct ctcatcaagc ctggtacttg ctacagccaa gagacaatgg aaacaagtca    900

tccaaaactg atgacctggg gtctcttcga ttaaatatat gttatacaga agactacgtg    960

cttccttcag agtactatgg tcctttgaaa actttgctgc taaaatcacc agatgttcaa   1020

ccaatatctg cctcagctgc ttacattttg agtgaaatat gtcgagataa aaatgatgct   1080

gttttgcccc ttgtacgact gctgctgcac catgataaac ttgttccttt tgccactgct   1140

gtggctgaat tagacttgaa ggatacacaa gatgcaaaca caatttttag aggaaattcc   1200

ctggctaccc gatgtctgga tgagatgatg aaaatagtgg gagggcacta cctgaaagta   1260

acattaaaac ctattcttga tgagatatgt gactcctcaa aatcctgtga aatcgatcct   1320

attaaattga aagagggaga taatgtagaa aataataagg agaatctgcg ctactatgta   1380

gacaagttat tcaatacaat tgtaaaatca agtatgagct gccccactgt aatgtgtgat   1440

atcttttatt ctctaaggca gatggctact cagagatttc ctaatgaccc tcatgttcag   1500

tattctgcag tgagcagctt tgtatttctt cgtttctttg ctgtagccgt agtatcacct   1560

catacttttc atttgcgacc tcatcatcca gatgcacaga caattagaac attaactctc   1620

atctcaaaaa ctatacaaac tttgggaagc tgggggagtc tgtccaaaag caagtcaagt   1680

ttcaaagaga cattcatgtg tgaatttttc aaaatgtttc aagaagaagg atatattata   1740

gcagttaaaa agttcttgga tgaaatttca tctactgaaa ctaaagagtc cagtggtacg   1800

agtgagcctg tgcacctgaa agaaggtgag atgtataaaa gagctcaagg aagaactcgg   1860

attggaaaaa agaattttaa gaaacgatgg ttctgcttaa caagcagaga gctcacctac   1920

cacaaacagc caggcaaaga tgcaatctac acaatcccag taaaaaacat tcttgctgtg   1980

gaaaaactgg aagagagctc tttcaacaag aaaaatatgt tccaagtaat acatacggag   2040

aaaccactct atgtccaggc aaataactgt gtagaagcta atgaatggat agacgtactc   2100

tgcagggtga gccgatgcaa tcaaaacagg ctcagttttt atcatccctc tgtgtatcta   2160

aacggaaatt ggctctgctg tcaggagact ggtgaaaaca ctctcggctg caagccatgt   2220

actgcaggtg tccctgcaga catccaaata gatattgatg aagacagaga aacagaaaga   2280

atttattccc tttttaccct cagtttactt aagctgcaga agatggaaga ggcttgtgga   2340

actattgcag tctatcaagg accacagaaa gagcctgatg attattctaa ctttgtaatc   2400

gaggattctg taacaacctt taagacaatt cagcaaataa aaagcataat tgagaagctg   2460

gatgaacctc atgaaaaata taggaagaaa agatccagta gtgcaaaata tgggagcaag   2520

gaaaatccaa ttgttgggaa agcatcttag agtttaacag attggttcag aagaactgga   2580

aaatattatt tt                                                       2592


<210>  252
<211>  849
<212>  PRT
<213>  Homosapiens

<400>  252

Met Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Ser Ser Glu Ala Pro 
1               5                   10                  15      


Ala Ala Ser Ala Thr Ala Glu Pro Glu Ala Gly Asp Gln Asp Ser Arg 
            20                  25                  30          


Glu Val Arg Val Leu Gln Ser Leu Arg Gly Lys Ile Cys Glu Ala Lys 
        35                  40                  45              


Asn Leu Leu Pro Tyr Leu Gly Pro His Lys Met Arg Asp Cys Phe Cys 
    50                  55                  60                  


Thr Ile Asn Leu Asp Gln Glu Glu Val Tyr Arg Thr Gln Val Val Glu 
65                  70                  75                  80  


Lys Ser Leu Ser Pro Phe Phe Ser Glu Glu Phe Tyr Phe Glu Ile Pro 
                85                  90                  95      


Arg Thr Phe Gln Tyr Leu Ser Phe Tyr Val Tyr Asp Lys Asn Val Leu 
            100                 105                 110         


Gln Arg Asp Leu Arg Ile Gly Lys Val Ala Ile Lys Lys Glu Asp Leu 
        115                 120                 125             


Cys Asn His Ser Gly Lys Glu Thr Trp Phe Ser Leu Gln Pro Val Asp 
    130                 135                 140                 


Ser Asn Ser Glu Val Gln Gly Lys Val His Leu Glu Leu Lys Leu Asn 
145                 150                 155                 160 


Glu Leu Ile Thr Glu Asn Gly Thr Val Cys Gln Gln Leu Val Val His 
                165                 170                 175     


Ile Lys Ala Cys His Gly Leu Pro Leu Ile Asn Gly Gln Ser Cys Asp 
            180                 185                 190         


Pro Tyr Ala Thr Val Ser Leu Val Gly Pro Ser Arg Asn Asp Gln Lys 
        195                 200                 205             


Lys Thr Lys Val Lys Lys Lys Thr Ser Asn Pro Gln Phe Asn Glu Ile 
    210                 215                 220                 


Phe Tyr Phe Glu Val Thr Arg Ser Ser Ser Tyr Thr Arg Lys Ser Gln 
225                 230                 235                 240 


Phe Gln Val Glu Glu Glu Asp Ile Glu Lys Leu Glu Ile Arg Ile Asp 
                245                 250                 255     


Leu Trp Asn Asn Gly Asn Leu Val Gln Asp Val Phe Leu Gly Glu Ile 
            260                 265                 270         


Lys Val Pro Val Asn Val Leu Arg Thr Asp Ser Ser His Gln Ala Trp 
        275                 280                 285             


Tyr Leu Leu Gln Pro Arg Asp Asn Gly Asn Lys Ser Ser Lys Thr Asp 
    290                 295                 300                 


Asp Leu Gly Ser Leu Arg Leu Asn Ile Cys Tyr Thr Glu Asp Tyr Val 
305                 310                 315                 320 


Leu Pro Ser Glu Tyr Tyr Gly Pro Leu Lys Thr Leu Leu Leu Lys Ser 
                325                 330                 335     


Pro Asp Val Gln Pro Ile Ser Ala Ser Ala Ala Tyr Ile Leu Ser Glu 
            340                 345                 350         


Ile Cys Arg Asp Lys Asn Asp Ala Val Leu Pro Leu Val Arg Leu Leu 
        355                 360                 365             


Leu His His Asp Lys Leu Val Pro Phe Ala Thr Ala Val Ala Glu Leu 
    370                 375                 380                 


Asp Leu Lys Asp Thr Gln Asp Ala Asn Thr Ile Phe Arg Gly Asn Ser 
385                 390                 395                 400 


Leu Ala Thr Arg Cys Leu Asp Glu Met Met Lys Ile Val Gly Gly His 
                405                 410                 415     


Tyr Leu Lys Val Thr Leu Lys Pro Ile Leu Asp Glu Ile Cys Asp Ser 
            420                 425                 430         


Ser Lys Ser Cys Glu Ile Asp Pro Ile Lys Leu Lys Glu Gly Asp Asn 
        435                 440                 445             


Val Glu Asn Asn Lys Glu Asn Leu Arg Tyr Tyr Val Asp Lys Leu Phe 
    450                 455                 460                 


Asn Thr Ile Val Lys Ser Ser Met Ser Cys Pro Thr Val Met Cys Asp 
465                 470                 475                 480 


Ile Phe Tyr Ser Leu Arg Gln Met Ala Thr Gln Arg Phe Pro Asn Asp 
                485                 490                 495     


Pro His Val Gln Tyr Ser Ala Val Ser Ser Phe Val Phe Leu Arg Phe 
            500                 505                 510         


Phe Ala Val Ala Val Val Ser Pro His Thr Phe His Leu Arg Pro His 
        515                 520                 525             


His Pro Asp Ala Gln Thr Ile Arg Thr Leu Thr Leu Ile Ser Lys Thr 
    530                 535                 540                 


Ile Gln Thr Leu Gly Ser Trp Gly Ser Leu Ser Lys Ser Lys Ser Ser 
545                 550                 555                 560 


Phe Lys Glu Thr Phe Met Cys Glu Phe Phe Lys Met Phe Gln Glu Glu 
                565                 570                 575     


Gly Tyr Ile Ile Ala Val Lys Lys Phe Leu Asp Glu Ile Ser Ser Thr 
            580                 585                 590         


Glu Thr Lys Glu Ser Ser Gly Thr Ser Glu Pro Val His Leu Lys Glu 
        595                 600                 605             


Gly Glu Met Tyr Lys Arg Ala Gln Gly Arg Thr Arg Ile Gly Lys Lys 
    610                 615                 620                 


Asn Phe Lys Lys Arg Trp Phe Cys Leu Thr Ser Arg Glu Leu Thr Tyr 
625                 630                 635                 640 


His Lys Gln Pro Gly Lys Asp Ala Ile Tyr Thr Ile Pro Val Lys Asn 
                645                 650                 655     


Ile Leu Ala Val Glu Lys Leu Glu Glu Ser Ser Phe Asn Lys Lys Asn 
            660                 665                 670         


Met Phe Gln Val Ile His Thr Glu Lys Pro Leu Tyr Val Gln Ala Asn 
        675                 680                 685             


Asn Cys Val Glu Ala Asn Glu Trp Ile Asp Val Leu Cys Arg Val Ser 
    690                 695                 700                 


Arg Cys Asn Gln Asn Arg Leu Ser Phe Tyr His Pro Ser Val Tyr Leu 
705                 710                 715                 720 


Asn Gly Asn Trp Leu Cys Cys Gln Glu Thr Gly Glu Asn Thr Leu Gly 
                725                 730                 735     


Cys Lys Pro Cys Thr Ala Gly Val Pro Ala Asp Ile Gln Ile Asp Ile 
            740                 745                 750         


Asp Glu Asp Arg Glu Thr Glu Arg Ile Tyr Ser Leu Phe Thr Leu Ser 
        755                 760                 765             


Leu Leu Lys Leu Gln Lys Met Glu Glu Ala Cys Gly Thr Ile Ala Val 
    770                 775                 780                 


Tyr Gln Gly Pro Gln Lys Glu Pro Asp Asp Tyr Ser Asn Phe Val Ile 
785                 790                 795                 800 


Glu Asp Ser Val Thr Thr Phe Lys Thr Ile Gln Gln Ile Lys Ser Ile 
                805                 810                 815     


Ile Glu Lys Leu Asp Glu Pro His Glu Lys Tyr Arg Lys Lys Arg Ser 
            820                 825                 830         


Ser Ser Ala Lys Tyr Gly Ser Lys Glu Asn Pro Ile Val Gly Lys Ala 
        835                 840                 845             


Ser 
    


<210>  253
<211>  4928
<212>  DNA
<213>  Homosapiens

<400>  253
acagtagaaa gtcagaaggt cacaaagctt gcagggtaag tgacacaact tgaaactgct     60

tggccctctt taaaaagaaa taataaaatg ggagagaatg aagcaagttt acctaacacg    120

tctttgcaag gtaaaaagat ggcctatcag aaggtccatg cagatcaaag agctccagga    180

cactcacagt acttagacaa tgatgacctt caagccactg cccttgactt agagtgggac    240

atggagaagg aactagagga gtctggtttt gaccaattcc agctagacgg tgctgagaat    300

cagaacctag ggcattcaga gactatagac ctcaatcttg attccattca accagcaact    360

tcacccaaag gaaggttcca gagacttcaa gaagaatctg actacattac ccattataca    420

cgatctgcac caaagagcaa tcgctgcaac ttttgccacg tcttaaaaat actttgcaca    480

gccaccattt tatttatttt tgggattttg ataggttatt atgtacatac aaattgccct    540

tcagatgctc catcttcagg aacagttgat cctcagttat atcaagagat tctcaagaca    600

atccaggcag aagatattaa gaagtctttc agaaatttgg tacaactata taaaaatgaa    660

gatgacacgg aaatttcaaa gaagattaag actcagtgga cctctttggg cctagaagat    720

gtacagtttg taaattactc tgtgctgctt gatctgccag gcccttctcc cagcactgtg    780

actctgagca gcagtggtca atgctttcat cctaatggcc agccttgcag tgaagaagcc    840

agaaaagata gcagccaaga cctgctctat tcatatgcag cctattctgc caaaggaact    900

ctcaaggctg aagtcatcga tgtgagttat ggaatggcag atgatttaaa aaggattagg    960

aaaataaaaa acgtaacaaa tcagatcgca ctcctgaaat taggaaaatt gccactgctt   1020

tataagcttt cctcattgga aaaggctgga tttggaggtg ttcttctgta tatcgatcct   1080

tgtgatttgc caaagactgt gaatcctagc catgatacct tcatggtgtc actgaatcca   1140

ggaggagacc cttctacgcc tggttaccca agtgtcgatg aaagttttag acaaagccga   1200

tcaaacctca cctctctatt agtgcagccc atctctgcat ccctcgttgc aaaactgatc   1260

tcttcgccaa aagctagaac caaaaatgaa gcgtgtagct ctctagagct tccaaataat   1320

gaaataagag tcgtcagcat gcaagttcag acagtcacaa aattgaaaac agttactaat   1380

gttgttggat ttgtaatggg cttgacatct ccagaccggt atatcatagt tggcagccat   1440

catcacactg cacacagtta taatggacaa gaatgggcca gtagtactgc aataatcaca   1500

gcgtttatcc gtgccttgat gtcaaaagtt aagagagggt ggagaccaga ccgaactatt   1560

gttttctgtt cttggggagg aacagctttt ggcaatattg gctcatatga atggggagag   1620

gatttcaaga aggttcttca aaaaaatgtt gtggcttata ttagcctcca cagtcccata   1680

agggggaact ctagtctgta tcctgtagca tcaccatctc ttcagcaact ggtagtagag   1740

aaaaataatt tcaactgtac cagaagagcc cagtgcccag aaaccaatat cagttctata   1800

cagatacaag gtgatgctga ttatttcatc aaccatcttg gagttcccat cgtgcagttt   1860

gcttacgagg acatcaaaac attagagggt ccaagttttc tctccgaggc ccgtttttct   1920

acacgagcaa caaaaattga agaaatggat cgctctttca accttcatga aaccattact   1980

aagctctcag gagaagtgat tttgcaaatt gccaacgaac ctgttctgcc ctttaatgca   2040

cttgatatag ctttagaagt tcaaaacaac cttaaaggtg atcaacccaa cactcatcaa   2100

ctgttagcca tggcgtcacg cctgcgggag agtgctgaac tttttcagtc tgatgagatg   2160

cgacctgcta atgatcccaa ggagagagca cccatccgca tccggatgct gaatgacatt   2220

ctccaagaca tggagaaaag ctttctggta aagcaggcac caccaggttt ttatagaaac   2280

atcctctacc accttgatga aaagacaagc cggttttcaa tacttataga ggcttgggaa   2340

cactgcaaac cccttgcatc aaatgagacc cttcaagaag ccctgtcaga ggtgttgaac   2400

agcattaatt cagctcaggt ttacttcaaa gcaggacttg atgtgttcaa gagtgtcttg   2460

gatgggaaga attgagaaaa ctctgagcat ttttaaaagt ttgtttacaa ttccacaagc   2520

aaaagctcta atttaaccag attttctgac attgaaggct tattttcccc aatggctttt   2580

tgacaagtat aaagctatta ttacattgta ttttttaaat gtaaatatag aaagaacatt   2640

ttgcacattt aatatttttc ttatatctac atttctgaat atgtaaagca agttattgaa   2700

ataggactta agaattacct attaaaaaga aatctgatat ataaaaatat gtactatttt   2760

aaggaaaaat ttccaagaag ttctggacta tctttgttcc tatggggagg gcatatagga   2820

acacagttta ttctctctga tagagctatt aatgacttag tttctgtaaa agaaatggag   2880

agttgatatg gttcagatta acttcactat taagtgttca atatgaagaa ttcaagtatt   2940

ctgactgagt gattggttga cctaaaccac tttgaatgtt tctattttat gagatgaagt   3000

ttctcttctt aacacaacta gatgtagtaa tacactggtt atgaaattgt atttttttaa   3060

gtattaatga aaaaagagcc ataagcattc caggggaaaa tctcaaggga gctacataga   3120

gcaatttaaa tgcaaatttt tttcctaaca acttacaagg tgactagctt tgaaacccct   3180

aatttgcctc agttgatttt ctaagaattt caggagtgat gtatgtctta agagggagaa   3240

aaaaatattt cttattactt tttctcttgt ttctgttgga aacactgaag cagggactct   3300

aaaatgaaag catctcacat tggttttctt tcttgtatct tttctgaaac tccttgctgt   3360

aaggcagctt tctcagagta ctatatattt ccaacagtaa agtagcagag tttctctttg   3420

aaacccaaaa tgtcttctaa agaatcaaat ttctatttct gcctctgaca aaaagaactt   3480

actatgaaag aaatagttgt tttatcaata aaagcccctt aatattatga agaaactttt   3540

catatttttt cttctttatc cttaattgtg actaagatgg aaatctagaa aatattcatg   3600

cttctaagtt tctgcagtgt tactgtaaga gagtgtctcg tctacacttc agttcttctc   3660

tcatgtggaa aactaagctt tttatattga cattgccatt gaatagctct agcaactatt   3720

attattcccc caaaccctaa aattctacct attaggtgtc aggttaaagt tctaatttat   3780

ctttagaaat ttatgtgaaa aatggttttc ctatactgga taaagcaatt ccccttagga   3840

aacatagcct cagagtattt catataaatt ttctctatct aattcaaaca tatctcccca   3900

tgatacaccg ccagagtgac attgcagaca gtctgtgtat gtttaaattt tcacttttta   3960

tggatgagca taaacctagt cttagtttaa aggcaaacta aagttgaggg gaaataatta   4020

atcaatactg attaattgat ttataaggtt caacactgtc taccctaaat aatttttata   4080

tgctcaaggc aaagcaggga atagaggcaa ttagctagat aattcaagca gaaatccatt   4140

ttcatcgaaa ttgcctgtgt gcacatattt ttagatgaaa aatgaaacta ccttacaata   4200

ttattttttt aatcaatgta tttgtttgca aacatttgcc atgttgaaga gtgtgtatag   4260

gaaaggtcta gaaataaata ggcttgtgca tacctaggca ttcatgctct ttcttcctct   4320

tcagagatca tcagaaaaga ggtgggaata cacaagcagg tgcatgtaag cccaaaagct   4380

agaaagcctt atatttaacc aaaggttgat gtgttcattc cagttattca cttacagatg   4440

aaactaaaac aaataaaggc aagctattat cagtttggta gttcgttatt ttagaacaaa   4500

tttctaaatg aatttattcc cataacctac aatagcactg agaacagaaa acatgtttct   4560

tcttcatttt gtttaaagat tgcgtaccta ggtaagtcac actgtataga taaaaacctt   4620

cttctgtatt cctcacctct aaattatatg ttatttgcta tttgaaaact gtagttaact   4680

atggtttttt attagtctat taaaagatac gtggagatat taaattatac ctaaagcaga   4740

cgtccaacaa attctgtaca tgctgcttta catctttgca acaaacctct taactagcag   4800

cattatttct atagtgtgat tacctgaggg tgcctccaaa tgtatatcat ttcactcccc   4860

tcccctcccc acccccaata gattcaaata aataaaatcc tgagcaaatt aaaaaaaaaa   4920

aaaaaaaa                                                            4928


<210>  254
<211>  795
<212>  PRT
<213>  Homosapiens

<400>  254

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15      


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30          


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45              


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60                  


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80  


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95      


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110         


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125             


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140                 


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160 


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175     


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190         


Asp Thr Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205             


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220                 


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240 


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255     


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270         


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285             


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300                 


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala 
305                 310                 315                 320 


Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys 
                325                 330                 335     


Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly 
            340                 345                 350         


Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser Phe Arg 
        355                 360                 365             


Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala 
    370                 375                 380                 


Ser Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr Lys Asn 
385                 390                 395                 400 


Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg Val Val 
                405                 410                 415     


Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val 
            420                 425                 430         


Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val 
        435                 440                 445             


Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala 
    450                 455                 460                 


Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys 
465                 470                 475                 480 


Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp 
                485                 490                 495     


Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp 
            500                 505                 510         


Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His 
        515                 520                 525             


Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser 
    530                 535                 540                 


Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg 
545                 550                 555                 560 


Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp 
                565                 570                 575     


Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala 
            580                 585                 590         


Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala 
        595                 600                 605             


Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Arg Ser Phe 
    610                 615                 620                 


Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile Leu Gln 
625                 630                 635                 640 


Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile Ala Leu 
                645                 650                 655     


Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His Gln Leu 
            660                 665                 670         


Leu Ala Met Ala Ser Arg Leu Arg Glu Ser Ala Glu Leu Phe Gln Ser 
        675                 680                 685             


Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro Ile Arg 
    690                 695                 700                 


Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser Phe Leu 
705                 710                 715                 720 


Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr His Leu 
                725                 730                 735     


Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp Glu His 
            740                 745                 750         


Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu Ser Glu 
        755                 760                 765             


Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala Gly Leu 
    770                 775                 780                 


Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
785                 790                 795 


<210>  255
<211>  1972
<212>  DNA
<213>  Homosapiens

<400>  255
gaattcggca cgagggcgac cggcgcgtcg tgcggggctg cggcggagcc tccttaagga     60

aggtgcaaga ggttggcagc ttcgattgaa gcacatcgac cggcgacagc agccaggagt    120

catgagcgac agcggcgagc agaactacgg cgagcgggaa tcccgttctg cttccagaag    180

tggaagtgct cacggatcgg ggaaatctgc aaggcatacc cctgcaaggt ctcgctccaa    240

ggaagattcc aggcgttcca gatcaaagtc caggtcccga tctgaatcta ggtctagatc    300

cagaagaagc tcccgaaggc attatacccg gtcacggtct cgctcccgct cccatagacg    360

atcacgtagc aggtcttaca gtcgagatta tcgtagacgg cacagccaca gccattctcc    420

catgtctact cgcaggcgtc atgttgggaa tcgggcaaat cctgatccta actgttgtct    480

tggagtattt gggctgagct tgtacaccac agaaagagat ctaagagaag tgttctctaa    540

atatggtccc attgccgatg tgtctattgt atatgaccag cagtctaggc gttcaagagg    600

atttgccttt gtatattttg aaaatgtaga tgatgccaag gaagctaaag aacgtgccaa    660

tggaatggag cttgatgggc gtaggatcag agttgatttc tctataacaa aaagaccaca    720

tacgccaaca ccaggaattt acatggggag acctacctat ggcagctctc gccgtcggga    780

ttactatgac agaggatatg atcggggcta tgatgatcgg gactactata gcagatcata    840

cagaggagga ggtggaggag gaggaggatg gagagctgcc caagacaggg atcagattta    900

tagaaggcgg tcaccttctc cttactatag tcgtggagga tacagatcac gttccagatc    960

tcgatcatac tcacctcgtc gctattaaag catgaagact ttctgaaacc tgccctagag   1020

ctgggatatt gtttgtgggc aatatttttt attgtctctt gtttaaaaag tgaacagtgc   1080

ctagtgaagt taggtgactt ttacaccttt tacgatgact acttttggtg gagttgaaat   1140

gctgttttca ttctgcattt gtgtagtttg gtgctttgtt ccaagttaag tgttttcaga   1200

aaagtatgtt ttgcatgtat ttttttacag tctaaatttt gactgctgag aagtttctat   1260

tgtacaaaac ttcatttaaa aggtttttct actgaatcca gggtattctg aagatcgaag   1320

cctgtgtaaa atgctaccaa atggcaaaaa gcaacaataa acagtttgat ttttactttt   1380

ctttctaaca tatcaatgct tagcagaact attcagattg tcagtagtaa atttaaagac   1440

aaatgcccgt tttcctccag tccatgaaac ataccatact tatatacctg caactaagtg   1500

tttaaaatta tgctctgtaa ctctgtactg ctagtattag aactaaaaat cttaaaatac   1560

agccagtgct taatgcttat atcaatgtgg atttgtcggc ttttatgtaa tctgtaatat   1620

gtatagcagg aaatacgaag agttacacag tgtatgcctt aaaaggctgt ttcttaaagg   1680

tgttacaagg ggataatggt atttcaacta gttatcagca agtgacaata cattccacca   1740

caaatacact cttgttcttc tagcttttag actatatgaa aaaaccgggt gcttcaaagt   1800

acatgataag ggaacactat acctgtcatg gatgaactga agactttgcc tgttcatttt   1860

ttaaatatta ttttcaggtc ctttgcttac caaaggaggc ccaatttcac tcaaatgttt   1920

tgagaactgt gtttaaataa acgcaaatga aaagaaaaaa aaaaaaaaaa aa           1972


<210>  256
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  256

Met Ser Asp Ser Gly Glu Gln Asn Tyr Gly Glu Arg Glu Ser Arg Ser 
1               5                   10                  15      


Ala Ser Arg Ser Gly Ser Ala His Gly Ser Gly Lys Ser Ala Arg His 
            20                  25                  30          


Thr Pro Ala Arg Ser Arg Ser Lys Glu Asp Ser Arg Arg Ser Arg Ser 
        35                  40                  45              


Lys Ser Arg Ser Arg Ser Glu Ser Arg Ser Arg Ser Arg Arg Ser Ser 
    50                  55                  60                  


Arg Arg His Tyr Thr Arg Ser Arg Ser Arg Ser Arg Ser His Arg Arg 
65                  70                  75                  80  


Ser Arg Ser Arg Ser Tyr Ser Arg Asp Tyr Arg Arg Arg His Ser His 
                85                  90                  95      


Ser His Ser Pro Met Ser Thr Arg Arg Arg His Val Gly Asn Arg Ala 
            100                 105                 110         


Asn Pro Asp Pro Asn Cys Cys Leu Gly Val Phe Gly Leu Ser Leu Tyr 
        115                 120                 125             


Thr Thr Glu Arg Asp Leu Arg Glu Val Phe Ser Lys Tyr Gly Pro Ile 
    130                 135                 140                 


Ala Asp Val Ser Ile Val Tyr Asp Gln Gln Ser Arg Arg Ser Arg Gly 
145                 150                 155                 160 


Phe Ala Phe Val Tyr Phe Glu Asn Val Asp Asp Ala Lys Glu Ala Lys 
                165                 170                 175     


Glu Arg Ala Asn Gly Met Glu Leu Asp Gly Arg Arg Ile Arg Val Asp 
            180                 185                 190         


Phe Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met 
        195                 200                 205             


Gly Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg 
    210                 215                 220                 


Gly Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr 
225                 230                 235                 240 


Arg Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg 
                245                 250                 255     


Asp Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly 
            260                 265                 270         


Gly Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr 
        275                 280                 285             


<210>  257
<211>  2157
<212>  DNA
<213>  Homosapiens

<400>  257
atggggatat gtgaagggcc atgtagcacc ccctgcagta ggtactgcag cagctctact     60

ctgaattatg agatttctga ccttctttca gtgaacattc ttcctgatcc ttcctgtgtt    120

tcttcttctc ttgaccctgc aggagctcaa ggtggctctg tggccagggc aattttggag    180

agcaaaaaat ttgcagtgag agcagtgacc agggatgtga cttgaccaaa tgccctggag    240

ctccagcgcc ttggagctga ggtggtcaaa ggtgacctga atgataaagc atcggtggac    300

agtgccttaa aaggtgtcta tggggccttc ttggtgacca acttctggga ccctctcaac    360

caagataagg aagtgtgtcg ggggaagctg gtggcagact ccgccaagca cctgggtctg    420

aagcacgtgg tgtacagcgg cctggagaac gtcaagcgac tgacggatgg caagctggag    480

gtgccgcact ttgacagcaa gggcgaggtg gaggagtact tctggtccat tggcatcccc    540

atgaccagtg tccgcgtggc ggcctacttt gaaaactttc tcgcggcgtg gcggcccgtg    600

aaagcctctg atggagatta ctacaccttg gctgtaccga tgggagatgt accaatggat    660

ggtatctctg ttgctgatat tggagcagcc gtctctagca tttttaattc tccagaggaa    720

tttttaggca aggccgtggg gctcagtgca gaagcactaa caatacagca atatgctgat    780

gttttgtcca aggttttggg gaaagaagtc cgagatgcaa agactatctg tgctatagat    840

gaccagaaaa cagtggaaga aggtttcatg gaagacgtgg gcttgagttg gtccttgagg    900

gaacatgacc atattacccc ggaagctttc gagaagctgg gattccctgc agcaaaggaa    960

atagccaata tgtgtcgttt ctatgaaatg aagccagacc gagatgtcaa tctcacccac   1020

caactaaatc ccaaagtcaa aagcttcagc cagtttatct cagagaacca gggagccttc   1080

aagggcatac atgcgctggt caccttctct ggggtgaagt gccttctccg tgccggattt   1140

gagattaagg gaaggaaagg gaggaccaag ggattatcca aagactccag cactggctcg   1200

ccccatgcag aggaaggccc tcaggctaag gccggggccg agccttgctg gatgctggtg   1260

ctcctgctgc tggcttctcc gctggccaca ctgcttgtca tcctctcccc aacccaaggg   1320

acctttgcaa ctctgaaatc ccatcaagac tacacaaggg gcagagacaa ttcactaaaa   1380

ggaaactggg gcactgttag gaagtgcatg cacacacaag agaataacga aactaacact   1440

ggggtgagga caaggcagtg cttggcggag ggcgggctca acattcgcgc atgtgcagaa   1500

agagaatgcg gagccacggt gtcctcaggc taccggcaag gccgtggatc tgcgtggcta   1560

acggggggca agacaggggt cacggggctg agtgtggaag ccctgcgtgg aaatcgagag   1620

agccctcagg aggtcttggg ggatcaaacc caaaggtttc caagagccgg gctggtagat   1680

gaaggaaaca agccagatgt agcacagaag ggagtggtgg cgactgtacc gacaggagac   1740

cgattaattc ctgaaccctc tgattttgtg gaagggctgg gacttggtga agctgtaggt   1800

atcgtgagtg actggcctga tcacgagggg aaggagcacc cacagaatgc cagggtcctc   1860

ctctttggca gtggggaact attgggtgtt attatagcag ctatcatcac cttaatcaca   1920

tcaacactga aatatttgtt taccaaagaa aaatactttc catgctcctc tgactgtgtc   1980

atccacatga gccaccacca gcagcccaaa gccagttccg aagcagcaga acatttttcg   2040

agcaaaacag cactctgtga ccctcggagt gcttgttcag ctgaaattac ttgtgtctgg   2100

cacagacctt ctcttttgat tttggcagga tttcagggag tgaaaaagct aggttag      2157


<210>  258
<211>  718
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  258

Met Gly Ile Cys Glu Gly Pro Cys Ser Thr Pro Cys Ser Arg Tyr Cys 
1               5                   10                  15      


Ser Ser Ser Thr Leu Asn Tyr Glu Ile Ser Asp Leu Leu Ser Val Asn 
            20                  25                  30          


Ile Leu Pro Asp Pro Ser Cys Val Ser Ser Ser Leu Asp Pro Ala Gly 
        35                  40                  45              


Ala Gln Gly Gly Ser Val Ala Arg Ala Ile Leu Glu Ser Lys Lys Phe 
    50                  55                  60                  


Ala Val Arg Ala Val Thr Arg Asp Val Thr Xaa Pro Asn Ala Leu Glu 
65                  70                  75                  80  


Leu Gln Arg Leu Gly Ala Glu Val Val Lys Gly Asp Leu Asn Asp Lys 
                85                  90                  95      


Ala Ser Val Asp Ser Ala Leu Lys Gly Val Tyr Gly Ala Phe Leu Val 
            100                 105                 110         


Thr Asn Phe Trp Asp Pro Leu Asn Gln Asp Lys Glu Val Cys Arg Gly 
        115                 120                 125             


Lys Leu Val Ala Asp Ser Ala Lys His Leu Gly Leu Lys His Val Val 
    130                 135                 140                 


Tyr Ser Gly Leu Glu Asn Val Lys Arg Leu Thr Asp Gly Lys Leu Glu 
145                 150                 155                 160 


Val Pro His Phe Asp Ser Lys Gly Glu Val Glu Glu Tyr Phe Trp Ser 
                165                 170                 175     


Ile Gly Ile Pro Met Thr Ser Val Arg Val Ala Ala Tyr Phe Glu Asn 
            180                 185                 190         


Phe Leu Ala Ala Trp Arg Pro Val Lys Ala Ser Asp Gly Asp Tyr Tyr 
        195                 200                 205             


Thr Leu Ala Val Pro Met Gly Asp Val Pro Met Asp Gly Ile Ser Val 
    210                 215                 220                 


Ala Asp Ile Gly Ala Ala Val Ser Ser Ile Phe Asn Ser Pro Glu Glu 
225                 230                 235                 240 


Phe Leu Gly Lys Ala Val Gly Leu Ser Ala Glu Ala Leu Thr Ile Gln 
                245                 250                 255     


Gln Tyr Ala Asp Val Leu Ser Lys Val Leu Gly Lys Glu Val Arg Asp 
            260                 265                 270         


Ala Lys Thr Ile Cys Ala Ile Asp Asp Gln Lys Thr Val Glu Glu Gly 
        275                 280                 285             


Phe Met Glu Asp Val Gly Leu Ser Trp Ser Leu Arg Glu His Asp His 
    290                 295                 300                 


Ile Thr Pro Glu Ala Phe Glu Lys Leu Gly Phe Pro Ala Ala Lys Glu 
305                 310                 315                 320 


Ile Ala Asn Met Cys Arg Phe Tyr Glu Met Lys Pro Asp Arg Asp Val 
                325                 330                 335     


Asn Leu Thr His Gln Leu Asn Pro Lys Val Lys Ser Phe Ser Gln Phe 
            340                 345                 350         


Ile Ser Glu Asn Gln Gly Ala Phe Lys Gly Ile His Ala Leu Val Thr 
        355                 360                 365             


Phe Ser Gly Val Lys Cys Leu Leu Arg Ala Gly Phe Glu Ile Lys Gly 
    370                 375                 380                 


Arg Lys Gly Arg Thr Lys Gly Leu Ser Lys Asp Ser Ser Thr Gly Ser 
385                 390                 395                 400 


Pro His Ala Glu Glu Gly Pro Gln Ala Lys Ala Gly Ala Glu Pro Cys 
                405                 410                 415     


Trp Met Leu Val Leu Leu Leu Leu Ala Ser Pro Leu Ala Thr Leu Leu 
            420                 425                 430         


Val Ile Leu Ser Pro Thr Gln Gly Thr Phe Ala Thr Leu Lys Ser His 
        435                 440                 445             


Gln Asp Tyr Thr Arg Gly Arg Asp Asn Ser Leu Lys Gly Asn Trp Gly 
    450                 455                 460                 


Thr Val Arg Lys Cys Met His Thr Gln Glu Asn Asn Glu Thr Asn Thr 
465                 470                 475                 480 


Gly Val Arg Thr Arg Gln Cys Leu Ala Glu Gly Gly Leu Asn Ile Arg 
                485                 490                 495     


Ala Cys Ala Glu Arg Glu Cys Gly Ala Thr Val Ser Ser Gly Tyr Arg 
            500                 505                 510         


Gln Gly Arg Gly Ser Ala Trp Leu Thr Gly Gly Lys Thr Gly Val Thr 
        515                 520                 525             


Gly Leu Ser Val Glu Ala Leu Arg Gly Asn Arg Glu Ser Pro Gln Glu 
    530                 535                 540                 


Val Leu Gly Asp Gln Thr Gln Arg Phe Pro Arg Ala Gly Leu Val Asp 
545                 550                 555                 560 


Glu Gly Asn Lys Pro Asp Val Ala Gln Lys Gly Val Val Ala Thr Val 
                565                 570                 575     


Pro Thr Gly Asp Arg Leu Ile Pro Glu Pro Ser Asp Phe Val Glu Gly 
            580                 585                 590         


Leu Gly Leu Gly Glu Ala Val Gly Ile Val Ser Asp Trp Pro Asp His 
        595                 600                 605             


Glu Gly Lys Glu His Pro Gln Asn Ala Arg Val Leu Leu Phe Gly Ser 
    610                 615                 620                 


Gly Glu Leu Leu Gly Val Ile Ile Ala Ala Ile Ile Thr Leu Ile Thr 
625                 630                 635                 640 


Ser Thr Leu Lys Tyr Leu Phe Thr Lys Glu Lys Tyr Phe Pro Cys Ser 
                645                 650                 655     


Ser Asp Cys Val Ile His Met Ser His His Gln Gln Pro Lys Ala Ser 
            660                 665                 670         


Ser Glu Ala Ala Glu His Phe Ser Ser Lys Thr Ala Leu Cys Asp Pro 
        675                 680                 685             


Arg Ser Ala Cys Ser Ala Glu Ile Thr Cys Val Trp His Arg Pro Ser 
    690                 695                 700                 


Leu Leu Ile Leu Ala Gly Phe Gln Gly Val Lys Lys Leu Gly 
705                 710                 715             


<210>  259
<211>  4071
<212>  DNA
<213>  Homosapiens

<400>  259
gagtccagcc gctggtgcgc ggagcggttc accgtcttcg gagcggttcg gcccagcctt     60

tcgcccaggc gcccaggccc gctgcgcgcg tgcgtgagcg cgcctgcgcc gccagggccg    120

ctgcaagggg aggagagcgg ccgcctcagg aggatccctt ttcccccaga aattactcaa    180

tgctgaaacc tctcaaagtg gtattagaga cgctgaaagc accatggacg ggttttatga    240

tcagcaagtc ccttttatgg tcccagggaa atctcgatct gaggaatgca gagggcggcc    300

tgtgattgac agaaagagga agtttttgga cacagatctg gctcacgatt ctgaagagct    360

atttcaggat ctcagtcaac ttcaagaggc ttggttagct gaagcacaag ttcctgatga    420

tgaacagttt gtcccagatt ttcagtctga taacctggtg cttcatgccc cacctccaac    480

caagatcaaa cgggagctgc acagcccctc ctctgagctg tcgtcttgta gccatgagca    540

ggctcttggt gctaactatg gagaaaagtg cctctacaac tattgtgcct atgataggaa    600

gcctccctct gggttcaagc cattaacccc tcctacaacc cccctctcac ccacccatca    660

gaatccccta tttcccccac ctcaggcaac tctgcccacc tcagggcatg cccctgcagc    720

tggcccagtt caaggtgtgg gccccgcccc cgccccccat tcgcttccag agcctggacc    780

acagcagcaa acatttgcgg tcccccgacc accacatcag cccctgcaga tgccaaagat    840

gatgcctgaa aaccagtatc catcagaaca gagatttcag agacaactgt ctgaaccctg    900

ccaccccttc cctcctcagc caggagttcc tggagataat cgccccagtt accatcggca    960

aatgtcagaa cctattgtcc ctgcagctcc cccgccccct cagggattca aacaagaata   1020

ccatgaccca ctctatgaac atggggtccc gggcatgcca gggcccccag cacacgggtt   1080

ccagtcacca atgggaatca agcaggagcc tcgggattac tgcgtcgatt cagaagtgcc   1140

taactgccag tcatcctaca tgagaggggg ttatttctcc agcagccatg aaggtttttc   1200

atatgaaaaa gatccccgat tatactttga cgacacttgt gttgtgcctg agagactgga   1260

aggcaaagtc aaacaggagc ctaccatgta tcgagagggg cccccttacc agaggcgagg   1320

ttcccttcag ctgtggcagt tcctggtcac ccttcttgat gacccagcca atgcccactt   1380

cattgcctgg acaggtcgag gcatggagtt caagctgata gaaccggaag aggttgctcg   1440

gcgctggggc atccagaaga accggccagc catgaactat gacaagctga gccgctctct   1500

ccgctattac tatgaaaagg gcatcatgca gaaggtggct ggagagcgat acgtctacaa   1560

atttgtctgt gacccagatg ccctcttctc catggctttc ccggataacc agcgtccgtt   1620

cctgaaggca gagtccgagt gccacctcag cgaggaggac accctgccgc tgacccactt   1680

tgaagacagc cccgcttacc tcctggacat ggaccgctgc agcagcctcc cctatgccga   1740

aggctttgct tactaagttt ctgagtggcg gagtggccaa accctagagc tagcagttcc   1800

cattcaggca aacaagggca gtggttttgt ttgtgttttt ggttgttcct aaagcttgcc   1860

ctttgagtat tatctggaga acccaagctg tctctggatt ggcaccctta aagacagata   1920

cattggctgg ggagtgggaa cagggagggg cagaaaacca ccaaaaggcc agtgcctcaa   1980

ctcttgattc tgatgaggtt tctgggaaga gatcaaaatg gagtctcctt accatggaca   2040

atacatgcaa agcaatatct tgttcaggtt agtacccgca aaacgggaca tgatgtgaca   2100

atctcgatcg atcatggact actaaatggc ctttacatag aagggctctg atttgcacaa   2160

tttgttgaaa aatcacaaac ccatagaaaa gtgagtaggc taagttgggg aggctcaaac   2220

cattaagggt taaaaataca tcttaaacat tggaaagctc ttctagctga atctgaaata   2280

ttaccccttg tctagaaaaa ggggggcagt cagaacagct gttccccact ccgtgttctc   2340

aaaatcataa accatggcta ctcttgggaa ccacccggcc atgtggtcgc caagtagagc   2400

aagccccctt tctcttccca atcacgtggc tgagtgtgga tgacttttat tttaggagaa   2460

gggcgattaa cacttttgac agtattttgt tttgccctga tttgggggat tgttttgttt   2520

tggtggttgt tttggaaaaa cagtttataa actgattttt gtagttttgg tatttaaagc   2580

aaaaaaacga aaaacaaaaa acaaaaacaa accttttggt aatgtgcact gtgtctttag   2640

ccagggccgt gcaacttatg aagacactgc agcttgagag gggctttgct gaggcttccc   2700

cttggccatg tgaaagcccg ccttgttgcc tgctttgtgc tttctgcacc agacaacctg   2760

atggaacatt tgcacctgag ttgtacattt ttgaagtgtg cagggcagcc tggacacaag   2820

cttagattct ctatgtatag ttccccgtgt tcactaacat gccctctctg gaaagcatat   2880

gtatataaca tgtgtcatgt cctttggaaa cctggtcacc tggtgaaaac ccttgggatt   2940

cttccctggg catgactgat gacaatttcc atttcatcag tttgttttgt tttccttttt   3000

ctttaaatct tggactttaa accctacctg tgtgattcag tagggtttga gacttagctg   3060

tgatactgac aggtaagcaa cagtgctagc attctagatt cctgcctttt tttaaaaaga   3120

aattattctc attgctgtat tatattggaa aagttttaaa caaccaagct aaagctatgt   3180

gaaagttgag ctcaaagtag aggaaaagtt actggtggta ccttgctgcc tgctctgctg   3240

gtagaattct gtgctccccg tgacacttag tacattaaga atgactacac tgttcctcgt   3300

atgtgaagga ggcagtgctg actccgtgag tgtgagacac gtgctttgaa ctgcttttct   3360

attcatggag cactccatag tctcaaactg tcccccttat gaccaacagc acatttgtga   3420

agaggttcgc agggataagg ggtgcacttt atagctatgg aaacatgaga ttctcctcta   3480

ttggaagcta attagcccac aaaggtggta aacctgtaga ttgggcctta attagcattg   3540

tactctaatc aaaggactct ttctaaacca tatttatagc tttcttaacc tacacatagt   3600

ctatacatag atgcatattt tacccccagc tggctagaga tttatttgtt gtaaatgctg   3660

tatagatttg gttttccttt ctttacttac cctggtttgg attttttttt tttttttttt   3720

tgaatggatt tatgctgtct tagcaatatg acaataatcc tctgtagctt gagctacccc   3780

tcccctgctg taacttacgt gacctgtgct gtcactgggc ataggacagc ggcatcacgg   3840

ttgcattccc attggactca tgcacctccc ggatggtttt tgtttttttc gggggttctt   3900

tggggtttgt ttgtttgctt cttttccaga gtgtggaaag tctacagtgc agaaaggctt   3960

gaacctgcca gctgatttga aatactttca ccctgcgcag ggccgtatgc atcctgccaa   4020

gctgcgttat attctgtact gtgtacaata aagaagtttg cttttcgttt a            4071


<210>  260
<211>  510
<212>  PRT
<213>  Homosapiens

<400>  260

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys 
1               5                   10                  15      


Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg 
            20                  25                  30          


Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu 
65                  70                  75                  80  


His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser 
                85                  90                  95      


Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr 
            100                 105                 110         


Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro 
        115                 120                 125             


Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr 
    130                 135                 140                 


His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser 
145                 150                 155                 160 


Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro 
                165                 170                 175     


Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala 
            180                 185                 190         


Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro 
        195                 200                 205             


Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu 
    210                 215                 220                 


Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg 
225                 230                 235                 240 


Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro 
                245                 250                 255     


Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu 
            260                 265                 270         


His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser 
        275                 280                 285             


Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu 
    290                 295                 300                 


Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser 
305                 310                 315                 320 


Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp 
                325                 330                 335     


Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu 
            340                 345                 350         


Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu 
        355                 360                 365             


Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala 
    370                 375                 380                 


His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu 
385                 390                 395                 400 


Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala 
                405                 410                 415     


Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys 
            420                 425                 430         


Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val 
        435                 440                 445             


Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg 
    450                 455                 460                 


Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr 
465                 470                 475                 480 


Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met 
                485                 490                 495     


Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr 
            500                 505                 510 


<210>  261
<211>  3758
<212>  DNA
<213>  Homosapiens

<400>  261
cacggagata gacagctttg gagctgctga actccgagca cagggtgaag accccggcgc     60

taccaaccac agcctggcag cctggtctcc gcggcaccca ctggggctgc atccccctcc    120

cccgagaggg ctgcgcaggc gggaagacgc cagaggccag cttcggtccc ccttctgtct    180

ctcggttcct ctttcctccc aagtaaggga ataaaccgcg aagaaggagc gccccgggcc    240

accgcgcaac caagtgttgc ctggtgagga agagccagga cttctgaatt taccttgaat    300

acagacagga ggatgttgcc taaggaatag cagagatctt gtctcatctt ctgagaggtg    360

cctgctgctg ctgtatacac ttgagtgctc ccagaagtct cctgaaaggc ttacatcgca    420

aacctgcaat gagccaggcc ctgggctggg cctccacttc agcctagtga acaaaactcc    480

atcactgccc tttagccact cacataaagt ttaaaaatgg gtgaagaacg gtgggtctcc    540

ctcactccag aagaatttga ccaactccag aaatattcag aatattcctc caagaagata    600

aaagatgcct tgactgaatt taatgagggt gggagcctca aacaatatga cccacatgag    660

ccgattagct atgatgtctt caagctgttc atgagggcgt acctggaggt ggaccttccc    720

cagccactga gcactcacct cttcctggcc ttcagccaga agcccagaca cgagacctct    780

gaccacccga cggagggagc cagcaacagt gaggccaaca gcgcagatac taatatacag    840

aatgcagata atgccaccaa agcagacgag gcctgtgccc ctgatactga atcaaatatg    900

gctgagaagc aagcaccagc tgaagaccaa gtggctgcga cccccctgga accccccgtc    960

cctcggtctt caagctcgga atccccagtg gtgtacctga aggatgttgt gtgctacctg   1020

tccctgctgg agacggggag gcctcaggat aagctggagt tcatgtttcg cctctatgat   1080

tcagatgaga acggtctcct ggaccaagcg gagatggatt gcattgtcaa ccaaatgctg   1140

catattgccc agtacctgga gtgggatccc acagagctga ggcctatatt gaaggagatg   1200

ctgcaaggga tggactacga ccgggacggc tttgtgtctc tacaggaatg ggtccatgga   1260

gggatgacca ccatcccatt gctggtgctc ctggggatgg atgactctgg ctccaagggg   1320

gatggggggc acgcctggac catgaagcac ttcaagaaac caacctactg caacttctgc   1380

catatcatgc tcatgggcgt ccgcaagcaa ggcctgtgct gcacttactg taaatacact   1440

gtccacgaac gctgtgtgtc caaaaacatt cctggttgtg tcaaaacgta ctcaaaagcc   1500

aaaaggagtg gtgaggtgat gcagcacgca tgggtggaag ggaactcctc cgtcaagtgt   1560

gaccggtgcc acaaaagtat caagtgctac cagagtgtca ccgcgcggca ctgcgtgtgg   1620

tgccggatga cgtttcaccg caaatgtgaa ttatcaacgt tgtgtgacgg tggggaactc   1680

agagaccaca tcttactgcc cacctccata tgccccatca cccgggacag gccaggtgag   1740

aagtctgatg gctgcgtgtc cgccaagggc gaacttgtca tgcagtataa gatcatcccc   1800

accccgggta cccaccccct gctggtcttg gtgaacccca agagtggagg gagacaagga   1860

gaaagaattc ttcggaaatt ccactatctg ctcaacccca aacaagtttt caacctggac   1920

aatggggggc ctactccagg gttgaacttt ttccgtgata ctccagactt ccgtgttttg   1980

gcctgtggtg gagatgggac agttggctgg attttggatt gcattgataa ggccaacttt   2040

gcaaagcatc caccagtggc tgtcctgcct cttggaacag gaaatgacct tgcccgttgt   2100

ctccgctggg gaggaggtta tgaagggggc agcttgacaa aaatcctgaa agacattgag   2160

cagagcccct tggtgatgct ggaccgctgg catctggaag tcatccccag agaggaagtg   2220

gaaaacgggg accaggtccc atacagcatc atgaacaact atttctccat tggtgtggac   2280

gcttccattg cacacagatt ccatgtgatg agagagaaac atcctgaaaa attcaacagc   2340

aggatgaaga acaagctgtg gtactttgaa tttggcacct cggagacttt tgcagcgacc   2400

tgcaagaaac tccacgacca cattgagttg gagtgtgatg gggttggggt ggacctgagc   2460

aacatcttcc tggaaggcat tgccattctc aacattccca gcatgtacgg aggcaccaat   2520

ctctggggag aaaacaagaa gaaccgggct gtgatccggg aaagcaggaa gggtgtcact   2580

gaccccaaag aactgaaatt ctgcgttcaa gacctcagtg accagctcct tgaagtggtg   2640

gggctagaag gagccatgga gatggggcag atctacaccg gcctgaagag tgcaggcagg   2700

aggctggccc agtgcgcctc tgtcaccatc aggacaaaca agctgctgcc aatgcaagtg   2760

gatggagaac cctggatgca gccatgttgc acgattaaaa ttactcacaa gaaccaagcg   2820

cccatgatga tggggcctcc ccagaagagc agcttcttct cgttgagaag gaagagccgt   2880

tcaaaagact aaacagtgtg ccaaacacca gctaaaccaa gagagaaagc aagaaactat   2940

aatgcacact cacacacaat ttatgtgcac actcacacat gcacacacac acacacatac   3000

acactcttct ctaaccagtg gaagcaaagc cacccttcgg gaagaaaacg tcaccttgcc   3060

atacattctg tttcaacagt gggtacaccc ctaacagagc cagtgccaac aaaacatttt   3120

gaatggactt agggcccatg aggttgtggc tggcttaggc agcaacctcc acattcccac   3180

aggccttgag cagaattttc tgagactgaa gggaaatccc cctttctttc taccagccct   3240

gcaagtttcc tcatggacgc tcgcgaggag caggctgcag gtttcctgcc tatggtgaga   3300

tcagatgtgg ccaagggaag gagctctggt tccagagaat ttgcacaaag ttccctctgt   3360

acagagacaa aacggcctcc ggctctcaga gcataatcct tggcagggct cagcaggcgc   3420

acgttggttt cttggtcgtc ctttgagtga caacttctcc gtgaacctgc tgaagaggca   3480

gaaaggctgt ggaaagctgt atttccattc ttgggtttct gcgccgtcgg tgggcacttg   3540

ttattttcca ggaaccttct cctggtgtct acatgtttgc ttagaggcgg ctccaagagc   3600

cccagagctg cctgcatagc acaccttaga tgtggtattt attttcttag ttctgtgaac   3660

acctgggagg gagagcggag aaactgggat ttatttttca aattggtgtc ataatattgt   3720

gtaaaaaggg aaggaaaaaa aaaaccaccc ccagcttc                           3758


<210>  262
<211>  791
<212>  PRT
<213>  Homosapiens

<400>  262

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15      


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30          


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45              


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60                  


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80  


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95      


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110         


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125             


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140                 


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160 


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175     


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190         


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205             


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220                 


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240 


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255     


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Gly His 
            260                 265                 270         


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285             


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300                 


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Lys Asn Ile Pro Gly 
305                 310                 315                 320 


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335     


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350         


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365             


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380                 


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400 


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415     


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430         


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445             


Glu Arg Ile Leu Arg Lys Phe His Tyr Leu Leu Asn Pro Lys Gln Val 
    450                 455                 460                 


Phe Asn Leu Asp Asn Gly Gly Pro Thr Pro Gly Leu Asn Phe Phe Arg 
465                 470                 475                 480 


Asp Thr Pro Asp Phe Arg Val Leu Ala Cys Gly Gly Asp Gly Thr Val 
                485                 490                 495     


Gly Trp Ile Leu Asp Cys Ile Asp Lys Ala Asn Phe Ala Lys His Pro 
            500                 505                 510         


Pro Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Cys 
        515                 520                 525             


Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gly Ser Leu Thr Lys Ile Leu 
    530                 535                 540                 


Lys Asp Ile Glu Gln Ser Pro Leu Val Met Leu Asp Arg Trp His Leu 
545                 550                 555                 560 


Glu Val Ile Pro Arg Glu Glu Val Glu Asn Gly Asp Gln Val Pro Tyr 
                565                 570                 575     


Ser Ile Met Asn Asn Tyr Phe Ser Ile Gly Val Asp Ala Ser Ile Ala 
            580                 585                 590         


His Arg Phe His Val Met Arg Glu Lys His Pro Glu Lys Phe Asn Ser 
        595                 600                 605             


Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu Phe Gly Thr Ser Glu Thr 
    610                 615                 620                 


Phe Ala Ala Thr Cys Lys Lys Leu His Asp His Ile Glu Leu Glu Cys 
625                 630                 635                 640 


Asp Gly Val Gly Val Asp Leu Ser Asn Ile Phe Leu Glu Gly Ile Ala 
                645                 650                 655     


Ile Leu Asn Ile Pro Ser Met Tyr Gly Gly Thr Asn Leu Trp Gly Glu 
            660                 665                 670         


Asn Lys Lys Asn Arg Ala Val Ile Arg Glu Ser Arg Lys Gly Val Thr 
        675                 680                 685             


Asp Pro Lys Glu Leu Lys Phe Cys Val Gln Asp Leu Ser Asp Gln Leu 
    690                 695                 700                 


Leu Glu Val Val Gly Leu Glu Gly Ala Met Glu Met Gly Gln Ile Tyr 
705                 710                 715                 720 


Thr Gly Leu Lys Ser Ala Gly Arg Arg Leu Ala Gln Cys Ala Ser Val 
                725                 730                 735     


Thr Ile Arg Thr Asn Lys Leu Leu Pro Met Gln Val Asp Gly Glu Pro 
            740                 745                 750         


Trp Met Gln Pro Cys Cys Thr Ile Lys Ile Thr His Lys Asn Gln Ala 
        755                 760                 765             


Pro Met Met Met Gly Pro Pro Gln Lys Ser Ser Phe Phe Ser Leu Arg 
    770                 775                 780                 


Arg Lys Ser Arg Ser Lys Asp 
785                 790     


<210>  263
<211>  4295
<212>  DNA
<213>  Homosapiens

<400>  263
gaggaggttc ctgtagggcg gcacaaccag ggagggcgtg gaagctctgc atcccttctc     60

ccataccttg ctctacacat ctcttcatct gtatcctctg cagcatcctt gatgataaac    120

cagtaaatat gagttttgat catcctgaga aaaatgggcc ttggcctgca gacccaataa    180

accttccctc ccatggataa tagtgctaat tcctgaggac ctgaagggcc tgccgcccct    240

gggggattag ccagaagcag gcttgttttc ctgctcagaa caaagtgact tccctgaaca    300

catcttcatt atgattcaca ccaacctgaa gaaaaagttc agctgctgcg tcctggtctt    360

tcttctgttt gcagtcatct gtgtgtggaa ggaaaagaag aaagggagtt actatgattc    420

ctttaaattg caaaccaagg aattccaggt gttaaagagt ctggggaaat tggccatggg    480

gtctgattcc cagtctgtat cctcaagcag cacccaggac ccccacaggg gccgccagac    540

cctcggcagt ctcagaggcc tagccaaggc caaaccagag gcctccttcc aggtgtggaa    600

caaggacagc tcttccaaaa accttatccc taggctgcaa aagatctgga agaattacct    660

aagcatgaac aagtacaaag tgtcctacaa ggggccagga ccaggcatca agttcagtgc    720

agaggccctg cgctgccacc tccgggacca tgtgaatgta tccatggtag aggtcacaga    780

ttttcccttc aatacctctg aatgggaggg ttatctgccc aaggagagca ttaggaccaa    840

ggctgggcct tggggcaggt gtgctgttgt gtcgtcagcg ggatctctga agtcctccca    900

actaggcaga gaaatcgatg atcatgacgc agtcctgagg tttaatgggg cacccacagc    960

caacttccaa caagatgtgg gcacaaaaac taccattcgc ctgatgaact ctcagttggt   1020

taccacagag aagcgcttcc tcaaagacag tttgtacaat gaaggaatcc taattgtatg   1080

ggacccatct gtataccact cagatatccc aaagtggtac cagaatccgg attataattt   1140

ctttaacaac tacaagactt atcgtaagct gcaccccaat cagccctttt acatcctcaa   1200

gccccagatg ccttgggagc tatgggacat tcttcaagaa atctccccag aagagattca   1260

gccaaacccc ccatcctctg ggatgcttgg tatcatcatc atgatgacgc tgtgtgacca   1320

ggtggatatt tatgagttcc tcccatccaa gcgcaagact gacgtgtgct actactacca   1380

gaagttcttc gatagtgcct gcacgatggg tgcctaccac ccgctgctct atgagaagaa   1440

tttggtgaag catctcaacc agggcacaga tgaggacatc tacctgcttg gaaaagccac   1500

actgcctggc ttccggacca ttcactgcta agcacaggct cctcactctt ctccatcagg   1560

cattaaatga atggtctctt ggccacccca gcctgggaag aacattttcc tgaacaattc   1620

cagcctgctc cttttactct aggggcctct gtcagcaaga ccatggggac ttcaagagcc   1680

tgtggtcagg aaatcaggtc cagccttccc tgtagccaga cagtttatga gcccagagcc   1740

tcctgccaca cacatgcaca catatctagc attctttcca gacagcatcc tccccgcctt   1800

ccaccttggt agatgcaagg tctatctctc ccatcagggc tgccaaagct gggctttgtt   1860

tttcccagca gaatgatgcc attctcacaa accaatgctc tatattgctt gaagtctgca   1920

tctaaatatt gatttcacgt tttaaagaaa ttctcttaaa ttacaattgt gcccaatgca   1980

gggtggctct ggggggcaag taggtggtac aggggattgg aaacatgctc cgcgcctcca   2040

gagaaaagtt gctcccgagg tccatgcccc tggaacgtgt tcctatcact ctggctggtt   2100

gggctggtcc ttagactggg tgcttatgat taaagggtct tggttagccc actttccctc   2160

tccatgtgga gatggaaggt agagaaggat acagtgtcta tcctcaagtt gctacggttc   2220

agtgagagag gcagacatct gaacaggcag gtaggattca gtgtgctcag tgcactgggg   2280

atttggagag agatgggctt gctctctctg tgcacccagg agggccacgc acttaaaact   2340

gtgtttgtgg atcagagaag gctttatagc acagggggca ttcagatgag tcttagagga   2400

agagaagaaa catggcaagc agattacatc tgagccgttt gaattgtgtt tttctttctt   2460

cccatgttta ttttctaaga tctacctgaa cttagagact caagatattt ttttaggaaa   2520

cctcctaccc atgtctgagg tagcaagtgc agcctcacga cagataccag gcaatccaga   2580

gccacaaaac gtgattcctc caggctctgc ctggcctgac cctgtcctgt cagctgggtt   2640

tacataccag tcccattctt ccttttcaat acctaccccc aaatcttctc ctaaccacca   2700

tctgtttttt ttttttaaag cattttttgc tttaaaagca tcctgacccc aatttctttg   2760

agctcacggg ccttttgctg aaggtctctc agggtgtagt ggtgtggctc tctggactta   2820

acgtcactct cagaggtcag aaccttggag atcagaactg attctcacca ggtgtgagag   2880

gtgtggtagc agattgcaat gctctgcacc tcttccttgc aagtgagcaa cttcaggctc   2940

tctgggcaga ggctggccca ctgtagtttg cagacatgct ctccagatgg ttttactaag   3000

tcccctctcc ctgataggga atcctgctgg accagcgcag ccctggtgtg gagaggttaa   3060

aagacttgca caggatcacc aagtcatgct gtagagccag gattcctaga cccagggctc   3120

tgcactctca aggctggccc catgtgctca aggggatcta atgtttgggc tccaaactaa   3180

ccatctcgga gctgggctcc tcatttactg ccaaaccctc agcttatgta gctagaaagg   3240

gccctggagt gagaaagcct ggattttcaa attgatgctc ccctactgac tagctgtgcc   3300

actctgggca aatgctcttc cttgagcctg tttccacacc tgtaaagtgg ggatgatgat   3360

cctatctcac tgcttttgtg aggattacag gaaagcacct gtcctggctc tgtacctggc   3420

acgtagtagg tgctcagttc atgctggttt ccttcctgcc tttagtaggg acctgctctg   3480

tgctcacacc tcggctgcat gcaccctgct gtgacggagg ctagtgtgga agaggtcctg   3540

tcctcaggga attaactgtc ttattgggag acaacaactg tcctccttgg aacacccaag   3600

aaaccatgca aagcagtgga caacacagaa cacgccctcc tcctcgctgc ctgcagctcc   3660

aatctgattc tgcttgggaa tgggcggagc acgtgggctg cttaactgct gtataggaca   3720

agccccttac ccctctctgg gcccatgaat tcctggcttg gtttatgttc tgatttgaca   3780

cactgatttt aatcttcgaa tcatgacact gagtgcagag gaggtggcat tccgacagca   3840

ggacatacat gttggtgtga agactgggac gacactgggt agaatctagt ttttaattat   3900

tattaatata aaggatcaaa ttaatttaaa tatgattctg aagtctacag aacttttagt   3960

tctgtgctgt ctatgtggac actttggtaa aatgcaaatt atgatatgga cgttatcatt   4020

ggtctggtga gatgtttcat atttgtgaca gttaatttaa aaattatgag ttaatgctgc   4080

ctgtgtctat ggggttctgt cttctttgat agccatctat tcatctggat catgggaccc   4140

tctctaatcc ttccaccaat caaataagct attgctattg gtttggagtt gagatatcag   4200

tctcggaaac ttctgaaaaa tgctaataat tacccaagga ttatgtcaaa ttttaaaata   4260

aatgtgtgtg tgtttcttta aaaaaaaaaa aaaaa                              4295


<210>  264
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  264

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210>  265
<211>  4403
<212>  DNA
<213>  Homosapiens

<400>  265
gcccggcgtt aacaaaggga gccgataccg accggcgtgg gcgcggagcg ggcggccgcc     60

accgagcgtg ctgagcaacc gcagcctccg cggccgagag tgcagcgagc aaggggagag    120

ccagttgcgc agagccctgc aaccagcagt ccagggagaa gtggtgaatg tcatggagcc    180

cagctgaaat ggactggccc ccttgagcct gtcccaagcc ctggtgccag gtgtccatcc    240

ccgtgctgag atgagttttg atcatcctga gaaaaatggg ccttggcctg cagacccaat    300

aaaccttccc tcccatggat aatagtgcta attcctgagg acctgaaggg cctgccgccc    360

ctgggggatt agccagaagc aggcttgttt tcctgctcag aacaaagtga cttccctgaa    420

cacatcttca ttatgattca caccaacctg aagaaaaagt tcagctgctg cgtcctggtc    480

tttcttctgt ttgcagtcat ctgtgtgtgg aaggaaaaga agaaagggag ttactatgat    540

tcctttaaat tgcaaaccaa ggaattccag gtgttaaaga gtctggggaa attggccatg    600

gggtctgatt cccagtctgt atcctcaagc agcacccagg acccccacag gggccgccag    660

accctcggca gtctcagagg cctagccaag gccaaaccag aggcctcctt ccaggtgtgg    720

aacaaggaca gctcttccaa aaaccttatc cctaggctgc aaaagatctg gaagaattac    780

ctaagcatga acaagtacaa agtgtcctac aaggggccag gaccaggcat caagttcagt    840

gcagaggccc tgcgctgcca cctccgggac catgtgaatg tatccatggt agaggtcaca    900

gattttccct tcaatacctc tgaatgggag ggttatctgc ccaaggagag cattaggacc    960

aaggctgggc cttggggcag gtgtgctgtt gtgtcgtcag cgggatctct gaagtcctcc   1020

caactaggca gagaaatcga tgatcatgac gcagtcctga ggtttaatgg ggcacccaca   1080

gccaacttcc aacaagatgt gggcacaaaa actaccattc gcctgatgaa ctctcagttg   1140

gttaccacag agaagcgctt cctcaaagac agtttgtaca atgaaggaat cctaattgta   1200

tgggacccat ctgtatacca ctcagatatc ccaaagtggt accagaatcc ggattataat   1260

ttctttaaca actacaagac ttatcgtaag ctgcacccca atcagccctt ttacatcctc   1320

aagccccaga tgccttggga gctatgggac attcttcaag aaatctcccc agaagagatt   1380

cagccaaacc ccccatcctc tgggatgctt ggtatcatca tcatgatgac gctgtgtgac   1440

caggtggata tttatgagtt cctcccatcc aagcgcaaga ctgacgtgtg ctactactac   1500

cagaagttct tcgatagtgc ctgcacgatg ggtgcctacc acccgctgct ctatgagaag   1560

aatttggtga agcatctcaa ccagggcaca gatgaggaca tctacctgct tggaaaagcc   1620

acactgcctg gcttccggac cattcactgc taagcacagg ctcctcactc ttctccatca   1680

ggcattaaat gaatggtctc ttggccaccc cagcctggga agaacatttt cctgaacaat   1740

tccagcctgc tccttttact ctaggggcct ctgtcagcaa gaccatgggg acttcaagag   1800

cctgtggtca ggaaatcagg tccagccttc cctgtagcca gacagtttat gagcccagag   1860

cctcctgcca cacacatgca cacatatcta gcattctttc cagacagcat cctccccgcc   1920

ttccaccttg gtagatgcaa ggtctatctc tcccatcagg gctgccaaag ctgggctttg   1980

tttttcccag cagaatgatg ccattctcac aaaccaatgc tctatattgc ttgaagtctg   2040

catctaaata ttgatttcac gttttaaaga aattctctta aattacaatt gtgcccaatg   2100

cagggtggct ctggggggca agtaggtggt acaggggatt ggaaacatgc tccgcgcctc   2160

cagagaaaag ttgctcccga ggtccatgcc cctggaacgt gttcctatca ctctggctgg   2220

ttgggctggt ccttagactg ggtgcttatg attaaagggt cttggttagc ccactttccc   2280

tctccatgtg gagatggaag gtagagaagg atacagtgtc tatcctcaag ttgctacggt   2340

tcagtgagag aggcagacat ctgaacaggc aggtaggatt cagtgtgctc agtgcactgg   2400

ggatttggag agagatgggc ttgctctctc tgtgcaccca ggagggccac gcacttaaaa   2460

ctgtgtttgt ggatcagaga aggctttata gcacaggggg cattcagatg agtcttagag   2520

gaagagaaga aacatggcaa gcagattaca tctgagccgt ttgaattgtg tttttctttc   2580

ttcccatgtt tattttctaa gatctacctg aacttagaga ctcaagatat ttttttagga   2640

aacctcctac ccatgtctga ggtagcaagt gcagcctcac gacagatacc aggcaatcca   2700

gagccacaaa acgtgattcc tccaggctct gcctggcctg accctgtcct gtcagctggg   2760

tttacatacc agtcccattc ttccttttca atacctaccc ccaaatcttc tcctaaccac   2820

catctgtttt ttttttttaa agcatttttt gctttaaaag catcctgacc ccaatttctt   2880

tgagctcacg ggccttttgc tgaaggtctc tcagggtgta gtggtgtggc tctctggact   2940

taacgtcact ctcagaggtc agaaccttgg agatcagaac tgattctcac caggtgtgag   3000

aggtgtggta gcagattgca atgctctgca cctcttcctt gcaagtgagc aacttcaggc   3060

tctctgggca gaggctggcc cactgtagtt tgcagacatg ctctccagat ggttttacta   3120

agtcccctct ccctgatagg gaatcctgct ggaccagcgc agccctggtg tggagaggtt   3180

aaaagacttg cacaggatca ccaagtcatg ctgtagagcc aggattccta gacccagggc   3240

tctgcactct caaggctggc cccatgtgct caaggggatc taatgtttgg gctccaaact   3300

aaccatctcg gagctgggct cctcatttac tgccaaaccc tcagcttatg tagctagaaa   3360

gggccctgga gtgagaaagc ctggattttc aaattgatgc tcccctactg actagctgtg   3420

ccactctggg caaatgctct tccttgagcc tgtttccaca cctgtaaagt ggggatgatg   3480

atcctatctc actgcttttg tgaggattac aggaaagcac ctgtcctggc tctgtacctg   3540

gcacgtagta ggtgctcagt tcatgctggt ttccttcctg cctttagtag ggacctgctc   3600

tgtgctcaca cctcggctgc atgcaccctg ctgtgacgga ggctagtgtg gaagaggtcc   3660

tgtcctcagg gaattaactg tcttattggg agacaacaac tgtcctcctt ggaacaccca   3720

agaaaccatg caaagcagtg gacaacacag aacacgccct cctcctcgct gcctgcagct   3780

ccaatctgat tctgcttggg aatgggcgga gcacgtgggc tgcttaactg ctgtatagga   3840

caagcccctt acccctctct gggcccatga attcctggct tggtttatgt tctgatttga   3900

cacactgatt ttaatcttcg aatcatgaca ctgagtgcag aggaggtggc attccgacag   3960

caggacatac atgttggtgt gaagactggg acgacactgg gtagaatcta gtttttaatt   4020

attattaata taaaggatca aattaattta aatatgattc tgaagtctac agaactttta   4080

gttctgtgct gtctatgtgg acactttggt aaaatgcaaa ttatgatatg gacgttatca   4140

ttggtctggt gagatgtttc atatttgtga cagttaattt aaaaattatg agttaatgct   4200

gcctgtgtct atggggttct gtcttctttg atagccatct attcatctgg atcatgggac   4260

cctctctaat ccttccacca atcaaataag ctattgctat tggtttggag ttgagatatc   4320

agtctcggaa acttctgaaa aatgctaata attacccaag gattatgtca aattttaaaa   4380

taaatgtgtg tgtgtttctt taa                                           4403


<210>  266
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  266

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210>  267
<211>  3746
<212>  DNA
<213>  Homosapiens

<400>  267
gcccggcgtt aacaaaggga gccgataccg accggcgtgg gcgcggagcg ggcggccgcc     60

accgagcgtg ctgagcaacc gcagcctccg cggccgagag tgcagcgagc aaggggagag    120

ccagttgcgc agagccctgc aaccagcagt ccagggagaa gtggtgaatg tcatggagcc    180

cagctgaaat ggactggccc ccttgagcct gtcccaagcc ctggtgccag gtgtccatcc    240

ccgtgctgag atgagttttg atcatcctga gaaaaatggg ccttggcctg cagacccaat    300

aaaccttccc tcccatggat aatagtgcta attcctgagg acctgaaggg cctgccgccc    360

ctgggggatt agccagaagc agatgatcat gacgcagtcc tgaggtttaa tggggcaccc    420

acagccaact tccaacaaga tgtgggcaca aaaactacca ttcgcctgat gaactctcag    480

ttggttacca cagagaagcg cttcctcaaa gacagtttgt acaatgaagg aatcctaatt    540

gtatgggacc catctgtata ccactcagat atcccaaagt ggtaccagaa tccggattat    600

aatttcttta acaactacaa gacttatcgt aagctgcacc ccaatcagcc cttttacatc    660

ctcaagcccc agatgccttg ggagctatgg gacattcttc aagaaatctc cccagaagag    720

attcagccaa accccccatc ctctgggatg cttggtatca tcatcatgat gacgctgtgt    780

gaccaggtgg atatttatga gttcctccca tccaagcgca agactgacgt gtgctactac    840

taccagaagt tcttcgatag tgcctgcacg atgggtgcct accacccgct gctctatgag    900

aagaatttgg tgaagcatct caaccagggc acagatgagg acatctacct gcttggaaaa    960

gccacactgc ctggcttccg gaccattcac tgctaagcac aggctcctca ctcttctcca   1020

tcaggcatta aatgaatggt ctcttggcca ccccagcctg ggaagaacat tttcctgaac   1080

aattccagcc tgctcctttt actctagggg cctctgtcag caagaccatg gggacttcaa   1140

gagcctgtgg tcaggaaatc aggtccagcc ttccctgtag ccagacagtt tatgagccca   1200

gagcctcctg ccacacacat gcacacatat ctagcattct ttccagacag catcctcccc   1260

gccttccacc ttggtagatg caaggtctat ctctcccatc agggctgcca aagctgggct   1320

ttgtttttcc cagcagaatg atgccattct cacaaaccaa tgctctatat tgcttgaagt   1380

ctgcatctaa atattgattt cacgttttaa agaaattctc ttaaattaca attgtgccca   1440

atgcagggtg gctctggggg gcaagtaggt ggtacagggg attggaaaca tgctccgcgc   1500

ctccagagaa aagttgctcc cgaggtccat gcccctggaa cgtgttccta tcactctggc   1560

tggttgggct ggtccttaga ctgggtgctt atgattaaag ggtcttggtt agcccacttt   1620

ccctctccat gtggagatgg aaggtagaga aggatacagt gtctatcctc aagttgctac   1680

ggttcagtga gagaggcaga catctgaaca ggcaggtagg attcagtgtg ctcagtgcac   1740

tggggatttg gagagagatg ggcttgctct ctctgtgcac ccaggagggc cacgcactta   1800

aaactgtgtt tgtggatcag agaaggcttt atagcacagg gggcattcag atgagtctta   1860

gaggaagaga agaaacatgg caagcagatt acatctgagc cgtttgaatt gtgtttttct   1920

ttcttcccat gtttattttc taagatctac ctgaacttag agactcaaga tattttttta   1980

ggaaacctcc tacccatgtc tgaggtagca agtgcagcct cacgacagat accaggcaat   2040

ccagagccac aaaacgtgat tcctccaggc tctgcctggc ctgaccctgt cctgtcagct   2100

gggtttacat accagtccca ttcttccttt tcaataccta cccccaaatc ttctcctaac   2160

caccatctgt tttttttttt taaagcattt tttgctttaa aagcatcctg accccaattt   2220

ctttgagctc acgggccttt tgctgaaggt ctctcagggt gtagtggtgt ggctctctgg   2280

acttaacgtc actctcagag gtcagaacct tggagatcag aactgattct caccaggtgt   2340

gagaggtgtg gtagcagatt gcaatgctct gcacctcttc cttgcaagtg agcaacttca   2400

ggctctctgg gcagaggctg gcccactgta gtttgcagac atgctctcca gatggtttta   2460

ctaagtcccc tctccctgat agggaatcct gctggaccag cgcagccctg gtgtggagag   2520

gttaaaagac ttgcacagga tcaccaagtc atgctgtaga gccaggattc ctagacccag   2580

ggctctgcac tctcaaggct ggccccatgt gctcaagggg atctaatgtt tgggctccaa   2640

actaaccatc tcggagctgg gctcctcatt tactgccaaa ccctcagctt atgtagctag   2700

aaagggccct ggagtgagaa agcctggatt ttcaaattga tgctccccta ctgactagct   2760

gtgccactct gggcaaatgc tcttccttga gcctgtttcc acacctgtaa agtggggatg   2820

atgatcctat ctcactgctt ttgtgaggat tacaggaaag cacctgtcct ggctctgtac   2880

ctggcacgta gtaggtgctc agttcatgct ggtttccttc ctgcctttag tagggacctg   2940

ctctgtgctc acacctcggc tgcatgcacc ctgctgtgac ggaggctagt gtggaagagg   3000

tcctgtcctc agggaattaa ctgtcttatt gggagacaac aactgtcctc cttggaacac   3060

ccaagaaacc atgcaaagca gtggacaaca cagaacacgc cctcctcctc gctgcctgca   3120

gctccaatct gattctgctt gggaatgggc ggagcacgtg ggctgcttaa ctgctgtata   3180

ggacaagccc cttacccctc tctgggccca tgaattcctg gcttggttta tgttctgatt   3240

tgacacactg attttaatct tcgaatcatg acactgagtg cagaggaggt ggcattccga   3300

cagcaggaca tacatgttgg tgtgaagact gggacgacac tgggtagaat ctagttttta   3360

attattatta atataaagga tcaaattaat ttaaatatga ttctgaagtc tacagaactt   3420

ttagttctgt gctgtctatg tggacacttt ggtaaaatgc aaattatgat atggacgtta   3480

tcattggtct ggtgagatgt ttcatatttg tgacagttaa tttaaaaatt atgagttaat   3540

gctgcctgtg tctatggggt tctgtcttct ttgatagcca tctattcatc tggatcatgg   3600

gaccctctct aatccttcca ccaatcaaat aagctattgc tattggtttg gagttgagat   3660

atcagtctcg gaaacttctg aaaaatgcta ataattaccc aaggattatg tcaaatttta   3720

aaataaatgt gtgtgtgttt ctttaa                                        3746


<210>  268
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  268

Met Asn Ser Gln Leu Val Thr Thr Glu Lys Arg Phe Leu Lys Asp Ser 
1               5                   10                  15      


Leu Tyr Asn Glu Gly Ile Leu Ile Val Trp Asp Pro Ser Val Tyr His 
            20                  25                  30          


Ser Asp Ile Pro Lys Trp Tyr Gln Asn Pro Asp Tyr Asn Phe Phe Asn 
        35                  40                  45              


Asn Tyr Lys Thr Tyr Arg Lys Leu His Pro Asn Gln Pro Phe Tyr Ile 
    50                  55                  60                  


Leu Lys Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Leu Gln Glu Ile 
65                  70                  75                  80  


Ser Pro Glu Glu Ile Gln Pro Asn Pro Pro Ser Ser Gly Met Leu Gly 
                85                  90                  95      


Ile Ile Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile Tyr Glu Phe 
            100                 105                 110         


Leu Pro Ser Lys Arg Lys Thr Asp Val Cys Tyr Tyr Tyr Gln Lys Phe 
        115                 120                 125             


Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu Leu Tyr Glu 
    130                 135                 140                 


Lys Asn Leu Val Lys His Leu Asn Gln Gly Thr Asp Glu Asp Ile Tyr 
145                 150                 155                 160 


Leu Leu Gly Lys Ala Thr Leu Pro Gly Phe Arg Thr Ile His Cys 
                165                 170                 175 


<210>  269
<211>  735
<212>  DNA
<213>  Homosapiens

<400>  269
cggcggttga attgctgcgc ccagcgaggc aaccgcctcc gaacgccagg tgggggcgag     60

gcgtctcgga gtctcagaga caccaaggcc cctgcgacaa ggtggctgca gctaggccgg    120

gggcgtcagg acgacggagc gggttcgggt cggtgacacg cagacctgag ggagctgggc    180

ccgccttttc cgcccgcgcc ccaggccctt gcagatcgag atttgcgtcc tagagtggga    240

aaaaagcaga ggccagggcg ccgattttat ttggagagaa gcaagcatct ttgcctcttt    300

ggagtaggaa attcagactt gaaaaagtgg tgtgtggttg actctgtttc tcgccatgtc    360

ttctcacaag actttcacca ttaagcgatt cctggccaag aaacaaaagc aaaatcgtcc    420

catcccccag tggattcaga tgaaacctgg tagtaaaatc aggtacaact ccaaaaggag    480

gcattggaga agaaccaagc tgggtctata aggaattgca catgagatgg cacacatatt    540

tatgctgtat caagttcacg atcatcttac gatatcaagc tgaaaatgtc accactacct    600

ggacagttgc acatgtttta ctgggaatat ttttttctgt ttttctgtat gctctgtgct    660

agtagggtgg attcagtaat aaatatgtga aagcttttgt ttccaaaaaa aaaaaaaaaa    720

aaaaaaaaaa aaaaa                                                     735


<210>  270
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  270

Met Ser Ser His Lys Thr Phe Thr Ile Lys Arg Phe Leu Ala Lys Lys 
1               5                   10                  15      


Gln Lys Gln Asn Arg Pro Ile Pro Gln Trp Ile Gln Met Lys Pro Gly 
            20                  25                  30          


Ser Lys Ile Arg Tyr Asn Ser Lys Arg Arg His Trp Arg Arg Thr Lys 
        35                  40                  45              


Leu Gly Leu 
    50      


<210>  271
<211>  2226
<212>  DNA
<213>  Homosapiens

<400>  271
ggatttttag accgtggaga ctgcgctgcc ctgccctgca cctaccctca ctctccgtgt     60

tctcactaag gtggaaattg ccttccctca ctactgacga gaccatgtgt aaaagcgtga    120

ccacagatga gtggaagaaa gtcttctatg agaagatgga ggaggcaaag ccggctgaca    180

gctgggacct catcatagac cccaacctca agcacaatgt gctgagccct ggttggaagc    240

agtacctgga attgcatgct tcaggcaggt tccactgctc ctggtgctgg cacacctggc    300

agtcgcccta cgtggtcatc ctcttccaca tgttcctgga ccgcgcccag cgggcgggct    360

cggtgcgcat gcgcgtcttc aagcagctgt gctatgagtg cggcacggcg cggctggacg    420

agtccagcat gctggaggag aacatcgagg gcctggtgga caacctcatc accagcctgc    480

gcgagcagtg ctacggcgag cgtggcggcc agtaccgcat ccacgtggcc agccgccagg    540

acaaccggcg gcaccgcgga gagttctgcg aggcctgcca ggagggcatc gtgcactgga    600

agcccagcga gaagctgctg gaggaggagg cgaccaccta caccttctcc cgggcgccca    660

gccccaccaa gtcgcaggac cagacgggct caggctggaa cttctgctct atcccctggt    720

gcttgttttg ggccacggtc ctgctgctga tcatctacct gcagttctct ttccgtagct    780

ccgtataaga ttccgtggtt gggcccagag cctgtcgagg gtgccagtta gctgatgcga    840

gggtagagga gagacgtggg ttgagaatag tgtaaacttc tagcgctggt gatgtcactg    900

actcagtggg gatcttggac aaattataca gtttttccat ctataaaact cagggtttgg    960

gcaagatcat tggtttatca tagtgaaacc caggacccca aagttctgcg taggtgcctc   1020

agggactttt ggatttggaa agtaggctaa gctagtgggt gtctccaact cctgatctaa   1080

acacccatcc tccaactcct acctcctcct cttgcttcga tcagaacagc tttactttag   1140

atagggttcc atttaagatt tttgtaccaa aaaaaaaaaa aagtttaact acttttaaaa   1200

agtttgaaaa ttagaggact gggtgatctc aaaagggctt tccacagtaa tgagctcgac   1260

cttgctctta ttagtccctc acccctgccc ctcatgatct cccactttct ctagctgcag   1320

ccttaaatta gcttctttgc ccaccctgtg agcctcatcc gtgattctgc cttcacacac   1380

gcagcagagg tttcccttga agtgcaagag gtgggagatc aggctgttcc tttgctgcca   1440

ggtacacagg gtctcttttt tttgtttctc agattccagc ttctttccac tcagggcaga   1500

ttctggggtc tgcctgcctg aaagatggtg gttggggtgg ggtctcatag agttaggctt   1560

ctcacccact gcgtattaac tggcagagaa tttaggggag gttcagaaga cagagtttta   1620

gaagcaaagc acaaaatctc tgggaggcat tataatggag ggtcttcaga gttcggggac   1680

caagtctagc agattctcag cagtgctgat ggccagaatt caggagcagg ggcctggcct   1740

cctgggttct ttgctgaaat tatagttgaa tggctttctc acattggcca agcatgaggc   1800

ctcttgccaa agatcagctg tccccctaaa gccacaggga tggggtatct tcagcaagag   1860

agagggcgtt aaagatgtaa aatgctttgt ccatggggaa gtgcacagat atgtgggaga   1920

accttacaag gctctaaaat gagatgtgat atggcttgaa atgggaggag acactttctg   1980

acagtggggg gtctggaatg gaattggtgg ggacaggcag caagctgcac ttttgagggg   2040

cctcatttac cccacctctg ttaaaaactt gactactctc ctctttaata gaaagtcacc   2100

atcatctgta gtgatggagg aagggggtca cttatataaa gatgggacac tttaataaag   2160

acaggatatc ttccataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220

aaaaaa                                                              2226


<210>  272
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  272

Met Cys Lys Ser Val Thr Thr Asp Glu Trp Lys Lys Val Phe Tyr Glu 
1               5                   10                  15      


Lys Met Glu Glu Ala Lys Pro Ala Asp Ser Trp Asp Leu Ile Ile Asp 
            20                  25                  30          


Pro Asn Leu Lys His Asn Val Leu Ser Pro Gly Trp Lys Gln Tyr Leu 
        35                  40                  45              


Glu Leu His Ala Ser Gly Arg Phe His Cys Ser Trp Cys Trp His Thr 
    50                  55                  60                  


Trp Gln Ser Pro Tyr Val Val Ile Leu Phe His Met Phe Leu Asp Arg 
65                  70                  75                  80  


Ala Gln Arg Ala Gly Ser Val Arg Met Arg Val Phe Lys Gln Leu Cys 
                85                  90                  95      


Tyr Glu Cys Gly Thr Ala Arg Leu Asp Glu Ser Ser Met Leu Glu Glu 
            100                 105                 110         


Asn Ile Glu Gly Leu Val Asp Asn Leu Ile Thr Ser Leu Arg Glu Gln 
        115                 120                 125             


Cys Tyr Gly Glu Arg Gly Gly Gln Tyr Arg Ile His Val Ala Ser Arg 
    130                 135                 140                 


Gln Asp Asn Arg Arg His Arg Gly Glu Phe Cys Glu Ala Cys Gln Glu 
145                 150                 155                 160 


Gly Ile Val His Trp Lys Pro Ser Glu Lys Leu Leu Glu Glu Glu Ala 
                165                 170                 175     


Thr Thr Tyr Thr Phe Ser Arg Ala Pro Ser Pro Thr Lys Ser Gln Asp 
            180                 185                 190         


Gln Thr Gly Ser Gly Trp Asn Phe Cys Ser Ile Pro Trp Cys Leu Phe 
        195                 200                 205             


Trp Ala Thr Val Leu Leu Leu Ile Ile Tyr Leu Gln Phe Ser Phe Arg 
    210                 215                 220                 


Ser Ser Val 
225         


<210>  273
<211>  2072
<212>  DNA
<213>  Homosapiens

<400>  273
gaagtcagcc acacaggata aaggagggaa gggaaggagc agatcttttc ggtaggaaga     60

cagattttgt tgtcaggttc ctgggagtgc aagagcaagt caaaggagag agagaggaga    120

gaggaaaagc cagagggaga gagggggaga ggggatctgt tgcaggcagg ggaaggcgtg    180

acctgaatgg agaatgccag ccaattccag agacacacag ggacctcaga acaaagataa    240

ggcatcacgg acaccacacc gggcacgagc tcacaggcaa gtcaagctgg gaggaccaag    300

gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc tattatgctc    360

tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat atgtttggcc    420

agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg acttggaata    480

tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac ttggaatcct    540

cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg ctggcaacct    600

tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg gtcctctccc    660

ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag cgtttcacag    720

gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg gaggacgagg    780

agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc tcctgccgct    840

tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt gacaacctct    900

tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac cccaagagct    960

ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg cagtttgagg   1020

acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac atcaagatca   1080

aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa cccatcagca   1140

cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag aaccggggct   1200

ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct cctgtccatg   1260

ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc gtcagctgtg   1320

acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag attgagtgtc   1380

tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aaaaaatgaa atcgatctgg   1440

agagcgaact caagtcagag caagtgacag agtgaatgac gggaccccac acaatgcaga   1500

catccagaaa tggatcactc ccaagacccc tggggcccag agctgcacca cccctcccca   1560

cccacaacac ccccgtgccc ctttccatgt ggattagaat gggtgctgaa caacatgatc   1620

tcagcagttg aagctgctac gtgtgtgaaa gcaaattctc cacttgaggg tttgcccatc   1680

attcaaacac tattccagaa aataatgaaa aaaaaatgtg ggatttattt tagcacctct   1740

gagtggactg tacttttctc aacggaaaaa aaaaatgccc ttggtccttg agacaaaaga   1800

tttaatatac aaccatgtgg cctcaggctg accagatcaa agtggtttct aatccattct   1860

acatgtcaag tttaaatgaa ccagactgcc tgtgacttta tgaatctgaa ggtattacct   1920

gttgctgctt tcttaaccac catgagtagg taaagcaaat aataactcac agagtgtgga   1980

tttttgagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 2072


<210>  274
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  274

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Lys Asn Glu Ile Asp 
        355                 360                 365             


Leu Glu Ser Glu Leu Lys Ser Glu Gln Val Thr Glu 
    370                 375                 380 


<210>  275
<211>  4353
<212>  DNA
<213>  Homosapiens

<400>  275
gaagtcagcc acacaggata aaggagggaa gggaaggagc agatcttttc ggtaggaaga     60

cagattttgt tgtcaggttc ctgggagtgc aagagcaagt caaaggagag agagaggaga    120

gaggaaaagc cagagggaga gagggggaga ggggatctgt tgcaggcagg ggaaggcgtg    180

acctgaatgg agaatgccag ccaattccag agacacacag ggacctcaga acaaagataa    240

ggcatcacgg acaccacacc gggcacgagc tcacaggcaa gtcaagctgg gaggaccaag    300

gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc tattatgctc    360

tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat atgtttggcc    420

agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg acttggaata    480

tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac ttggaatcct    540

cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg ctggcaacct    600

tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg gtcctctccc    660

ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag cgtttcacag    720

gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg gaggacgagg    780

agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc tcctgccgct    840

tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt gacaacctct    900

tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac cccaagagct    960

ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg cagtttgagg   1020

acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac atcaagatca   1080

aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa cccatcagca   1140

cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag aaccggggct   1200

ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct cctgtccatg   1260

ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc gtcagctgtg   1320

acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag attgagtgtc   1380

tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aattgtagac tgtagagccc   1440

caggagagct ggaacacggg ctgatcacct tctctacaag gaacaacctc accacataca   1500

agtctgagat caaatactcc tgtcaggagc cctattacaa gatgctcaac aataacacag   1560

gtatatatac ctgttctgcc caaggagtct ggatgaataa agtattgggg agaagcctac   1620

ccacctgcct tccagtgtgt gggctcccca agttctcccg gaagctgatg gccaggatct   1680

tcaatggacg cccagcccag aaaggcacca ctccctggat tgccatgctg tcacacctga   1740

atgggcagcc cttctgcgga ggctcccttc taggctccag ctggatcgtg accgccgcac   1800

actgcctcca ccagtcactc gatccggaag atccgaccct acgtgattca gacttgctca   1860

gcccttctga cttcaaaatc atcctgggca agcattggag gctccggtca gatgaaaatg   1920

aacagcatct cggcgtcaaa cacaccactc tccaccccca gtatgatccc aacacattcg   1980

agaatgacgt ggctctggtg gagctgttgg agagcccagt gctgaatgcc ttcgtgatgc   2040

ccatctgtct gcctgaggga ccccagcagg aaggagccat ggtcatcgtc agcggctggg   2100

ggaagcagtt cttgcaaagg ttcccagaga ccctgatgga gattgaaatc ccgattgttg   2160

accacagcac ctgccagaag gcttatgccc cgctgaagaa gaaagtgacc agggacatga   2220

tctgtgctgg ggagaaggaa gggggaaagg acgcctgtgc gggtgactct ggaggcccca   2280

tggtgaccct gaatagagaa agaggccagt ggtacctggt gggcactgtg tcctggggtg   2340

atgactgtgg gaagaaggac cgctacggag tatactctta catccaccac aacaaggact   2400

ggatccagag ggtcaccgga gtgaggaact gaatttggct cctcagcccc agcaccacca   2460

gctgtgggca gtcagtagca gaggacgatc ctccgatgaa agcagccatt tctcctttcc   2520

ttcctcccat cccccctcct tcggcctatc cattactggg caatagagca ggtatcttca   2580

cccccttttc actctcttta aagagatgga gcaagagagt ggtcagaaca caggccgaat   2640

ccaggctcta tcacttacta gtttgcagtg ctgggcaggt gacttcatct cttcgaactt   2700

cagtttcttc ataagatgga aatgctatac cttacctacc tcgtaaaagt ctgatgagga   2760

aaagattaac taatagatgc atagcactta acagagtgca tagcatacac tgttttcaat   2820

aaatgcacct tagcagaagg tcgatgtgtc taccaggcag acgaagctct cttacaaacc   2880

cctgcctggg tcttagcatt gatcagtgac acacctctcc cctcaacctt gaccatctcc   2940

atctgccctt aaatgctgta tgcttttttg ccaccgtgca acttgcccaa catcaatctt   3000

caccctcatc cctaaaaaag taaaacagac aaggttctga gtcctgtggt atgtccccta   3060

gcaaatgtaa ctaggaacat gcactagatg acagattgcg ggagggcctg agagaagcag   3120

ggacaggagg gagcctgggg attgtggttt gggaaggcag acacctggtt ctagaactag   3180

ctctgccctt agccccctgt atgaccctat gcaagtcctc ctccctcatc tcaaagggtc   3240

ctcaaagctc tgacgatcta agatacaatg aagccatttt ccccctgata agatgaggta   3300

aagccaatgt aaccaaaagg caaaaattac aatcggttca aaggaacttt gatgcagaca   3360

aaatgctgct gctgctgctc ctgaaatacc cacccctttc cactacgggt gggttcccaa   3420

ggacatggga caggcaaagt gtgagccaaa ggatccttcc ttattcctaa gcagagcatc   3480

tgctctgggc cctggcctcc ttcccttctt gggaaactgg gctgcatgag gtgggccctg   3540

gtagtttgta ccccaggccc ctatactctt ccttcctatg tccacagctg accccaagca   3600

gccgttcccc gactcctcac ccctgagcct caccctgaac tccctcatct tgcaaggcca   3660

taagtgtttt ccaagcaaaa tgcctctccc atcctctctc aggaagcttc tagagacttt   3720

atgccctcca gagctccaag atataagccc tccaagggat cagaagctcc aagttcctgt   3780

cttctgtttt atagaaattg atcttccctg ggggacttta actcttgacc tgtatgcagc   3840

tgttggagta attccaggtc tcttgaaaaa aaagaggaag ataatggaga atgagaacat   3900

atatatatat atattaagcc ccaggctgaa tactcaggga cagcaattca cagcctgcct   3960

ctggttctat aaacaagtca ttctacctct ttgtgccctg ctgtttattc tgtaagggga   4020

aggtggcaat gggacccagc tccatcagac acttgtcaag ctagcagaaa ctccattttc   4080

aatgccaaag aagaactgta atgctgtttt ggaatcatcc caaggcatcc caagacacca   4140

tatcttccca tttcaagcac tgcctgggca caccccaaca tcccaggctg tggtggctcc   4200

tgtgggaact acctagatga agagagtatc atttatacct tctaggagct cctattggga   4260

gacatgaaac atatgtaatt gactaccatg taatagaaca aaccctgcca agtgctgctt   4320

tggaaagtca tggaggtaaa agaaagacca ttc                                4353


<210>  276
<211>  699
<212>  PRT
<213>  Homosapiens

<400>  276

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg 
        435                 440                 445             


Ile Phe Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala 
    450                 455                 460                 


Met Leu Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu 
465                 470                 475                 480 


Gly Ser Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu 
                485                 490                 495     


Asp Pro Glu Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser 
            500                 505                 510         


Asp Phe Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu 
        515                 520                 525             


Asn Glu Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Gln Tyr 
    530                 535                 540                 


Asp Pro Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu 
545                 550                 555                 560 


Ser Pro Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly 
                565                 570                 575     


Pro Gln Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln 
            580                 585                 590         


Phe Leu Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile 
        595                 600                 605             


Val Asp His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys 
    610                 615                 620                 


Val Thr Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp 
625                 630                 635                 640 


Ala Cys Ala Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu 
                645                 650                 655     


Arg Gly Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys 
            660                 665                 670         


Gly Lys Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys 
        675                 680                 685             


Asp Trp Ile Gln Arg Val Thr Gly Val Arg Asn 
    690                 695                 


<210>  277
<211>  4137
<212>  DNA
<213>  Homosapiens

<400>  277
gaagtcagcc acacaggata aaggagggaa gggaaggagc agatcttttc ggtaggaaga     60

cagattttgt tgtcaggttc ctgggagtgc aagagcaagt caaaggagag agagaggaga    120

gaggaaaagc cagagggaga gagggggaga ggggatctgt tgcaggcagg ggaaggcgtg    180

acctgaatgg agaatgccag ccaattccag agacacacag ggacctcaga acaaagataa    240

ggcatcacgg acaccacacc gggcacgagc tcacaggcaa gtcaagctgg gaggaccaag    300

gccgggcagc cgggagcacc caaggcagga aaatgaggtg gctgcttctc tattatgctc    360

tgtgcttctc cctgtcaaag gcttcagccc acaccgtgga gctaaacaat atgtttggcc    420

agatccagtc gcctggttat ccagactcct atcccagtga ttcagaggtg acttggaata    480

tcactgtccc agatgggttt cggatcaagc tttacttcat gcacttcaac ttggaatcct    540

cctacctttg tgaatatgac tatgtgaagg tagaaactga ggaccaggtg ctggcaacct    600

tctgtggcag ggagaccaca gacacagagc agactcccgg ccaggaggtg gtcctctccc    660

ctggctcctt catgtccatc actttccggt cagatttctc caatgaggag cgtttcacag    720

gctttgatgc ccactacatg gctgtggatg tggacgagtg caaggagagg gaggacgagg    780

agctgtcctg tgaccactac tgccacaact acattggcgg ctactactgc tcctgccgct    840

tcggctacat cctccacaca gacaacagga cctgccgagt ggagtgcagt gacaacctct    900

tcactcaaag gactggggtg atcaccagcc ctgacttccc aaacccttac cccaagagct    960

ctgaatgcct gtataccatc gagctggagg agggtttcat ggtcaacctg cagtttgagg   1020

acatatttga cattgaggac catcctgagg tgccctgccc ctatgactac atcaagatca   1080

aagttggtcc aaaagttttg gggcctttct gtggagagaa agccccagaa cccatcagca   1140

cccagagcca cagtgtcctg atcctgttcc atagtgacaa ctcgggagag aaccggggct   1200

ggaggctctc atacagggct gcaggaaatg agtgcccaga gctacagcct cctgtccatg   1260

ggaaaatcga gccctcccaa gccaagtatt tcttcaaaga ccaagtgctc gtcagctgtg   1320

acacaggcta caaagtgctg aaggataatg tggagatgga cacattccag attgagtgtc   1380

tgaaggatgg gacgtggagt aacaagattc ccacctgtaa aattgtagac tgtagagccc   1440

caggagagct ggaacacggg ctgatcacct tctctacaag gaacaacctc accacataca   1500

agtctgagat caaatactcc tgtcaggagc cctattacaa gatgctcaac aataacacag   1560

gtatatatac ctgttctgcc caaggagtct ggatgaataa agtattgggg agaagcctac   1620

ccacctgcct tccagagtgt ggtcagccct cccgctccct gccaagcctg gtcaagagga   1680

tcattggggg ccgaaatgct gagcctggcc tcttcccgtg gcaggccctg atagtggtgg   1740

aggacacttc gagagtgcca aatgacaagt ggtttgggag tggggccctg ctctctgcgt   1800

cctggatcct cacagcagct catgtgctgc gctcccagcg tagagacacc acggtgatac   1860

cagtctccaa ggagcatgtc accgtctacc tgggcttgca tgatgtgcga gacaaatcgg   1920

gggcagtcaa cagctcagct gcccgagtgg tgctccaccc agacttcaac atccaaaact   1980

acaaccacga tatagctctg gtgcagctgc aggagcctgt gcccctggga ccccacgtta   2040

tgcctgtctg cctgccaagg cttgagcctg aaggcccggc cccccacatg ctgggcctgg   2100

tggccggctg gggcatctcc aatcccaatg tgacagtgga tgagatcatc agcagtggca   2160

cacggacctt gtcagatgtc ctgcagtatg tcaagttacc cgtggtgcct cacgctgagt   2220

gcaaaactag ctatgagtcc cgctcgggca attacagcgt cacggagaac atgttctgtg   2280

ctggctacta cgagggcggc aaagacacgt gccttggaga tagcggtggg gcctttgtca   2340

tctttgatga cttgagccag cgctgggtgg tgcaaggcct ggtgtcctgg gggggacctg   2400

aagaatgcgg cagcaagcag gtctatggag tctacacaaa ggtctccaat tacgtggact   2460

gggtgtggga gcagatgggc ttaccacaaa gtgttgtgga gccccaggtg gaacggtgag   2520

ctgacttact tcctcggggc ctgcctcccc tgagcgaagc tacaccgcac ttccgacagc   2580

acactccaca ttacttatca gaccatatgg aatggaacac actgacctag cggtggcttc   2640

tcctaccgag acagccccca ggaccctgag aggcagagtg tggtataggg aaaaggctcc   2700

aggcaggaga cctgtgttcc tgagcttgtc caagtctctt tccctgtctg ggcctcactc   2760

taccgagtaa tacaatgcag gagctcaacc aaggcctctg tgccaatccc agcactcctt   2820

tccaggccat gcttcttacc ccagtggcct ttattcactc ctgaccactt atcaaaccca   2880

tcggtcctac tgttggtata actgagcttg gacctgacta ttagaaaatg gtttctaaca   2940

ttgaactgaa tgccgcatct gtatattttc ctgctctgcc ttctgggact agccttggcc   3000

taatccttcc tctaggagaa gagcattcag gttttgggag atggctcata gccaagcccc   3060

tctctcttag tgtgatccct tggagcacct tcatgcctgg ggtttctctc ccaaaagctt   3120

cttgcagtct aagccttatc ccttatgttc cccattaaag gaatttcaaa agacatggag   3180

aaagttggga aggtttgtgc tgactgctgg gagcagaata gccgtgggag gcccaccaag   3240

cccttaaatt cccattgtca actcagaaca catttgggcc catatgccac cctggaacac   3300

cagctgacac catgggcgtc cacacctgct gctccagaca agcacaaagc aatctttcag   3360

ccttgaaatg tattatctga aaggctacct gaagcccagg cccgaatatg gggacttagt   3420

cgattacctg gaaaaagaaa agacccacac tgtgtcctgc tgtgcttttg ggcaggaaaa   3480

tggaagaaag agtggggtgg gcacattaga agtcacccaa atcctgccag gctgcctggc   3540

atccctgggg catgagctgg gcggagaatc caccccgcag gatgttcaga gggacccact   3600

ccttcatttt tcagagtcaa aggaatcaga ggctcaccca tggcaggcag tgaaaagagc   3660

caggagtcct gggttctagt ccctgctctg cccccaactg gctgtataac ctttgaaaaa   3720

tcattttctt tgtctgagtc tctggttctc cgtcagcaac aggctggcat aaggtcccct   3780

gcaggttcct tctagctgga gcactcagag cttccctgac tgctagcagc ctctctggcc   3840

ctcacagggc tgattgttct ccttctccct ggagctctct ctcctgaaaa tctccatcag   3900

agcaaggcag ccagagaagc ccctgagagg gaatgattgg gaagtgtcca ctttctcaac   3960

cggctcatca aacacactcc tttgtctatg aatggcacat gtaaatgatg ttatattttg   4020

tatcttttat atcatatgct tcaccattct gtaaagggcc tctgcattgt tgctcccatc   4080

aggggtctca agtggaaata aaccctcgtg gataaccaaa aaaaaaaaaa aaaaaaa      4137


<210>  278
<211>  728
<212>  PRT
<213>  Homosapiens

<400>  278

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys 
        435                 440                 445             


Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 
    450                 455                 460                 


Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 
465                 470                 475                 480 


Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala 
                485                 490                 495     


His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser 
            500                 505                 510         


Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 
        515                 520                 525             


Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp 
    530                 535                 540                 


Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 
545                 550                 555                 560 


Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg 
                565                 570                 575     


Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly 
            580                 585                 590         


Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 
        595                 600                 605             


Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val 
    610                 615                 620                 


Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 
625                 630                 635                 640 


Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 
                645                 650                 655     


Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp 
            660                 665                 670         


Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly 
        675                 680                 685             


Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 
    690                 695                 700                 


Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser 
705                 710                 715                 720 


Val Val Glu Pro Gln Val Glu Arg 
                725             


<210>  279
<211>  2861
<212>  DNA
<213>  Homosapiens

<400>  279
aaatctgctg tgcatccaga gagcaaagtg ggatgatctg tcactacacc tgcagcacca     60

cgctcggagg acagctcctg cctgcagctt ccagacccag gaagcctgag gggaaggaag    120

gaagtacggg cgaaatcatc agattggctt cccagatttg ggaatctgaa gcgggcccac    180

atcttccggc caacttccat tgaacttccc agcactcgaa agggaccgaa atggagagca    240

aagaacccca gctcaaaggg attgtgacaa ggttattcag ccagcaggga tacttcctgc    300

agatgcaccc agatggtacc attgatggga ccaaggacga aaacagcgac tacactctct    360

tcaatctaat tcccgtgggc ctgcgtgtag tggccatcca aggagtgaag gctagcctct    420

atgtggccat gaatggtgaa ggctatctct acagttcaga tgttttcact ccagaatgca    480

aattcaagga atctgtgttt gaaaactact atgtgatcta ttcttccaca ctgtaccgcc    540

agcaagaatc aggccgagct tggtttctgg gactcaataa agaaggtcaa attatgaagg    600

ggaacagagt gaagaaaacc aagccctcat cacattttgt accgaaacct attgaagtgt    660

gtatgtacag agaaccatcg ctacatgaaa ttggagaaaa acaagggcgt tcaaggaaaa    720

gttctggaac accaaccatg aatggaggca aagttgtgaa tcaagattca acatagctga    780

gaactctccc cttcttccct ctctcatccc ttccccttcc cttccttccc atttacccat    840

ttccttccag taaatccacc caaggagagg aaaataaaat gacaacgcaa gacctagtgg    900

ctaagattct gcactcaaaa tcttcctttg tgtaggacaa gaaaattgaa ccaaagcttg    960

cttgttgcaa tgtggtagaa aattcacgtg cacaaagatt agcacactta aaagcaaagg   1020

aaaaaataaa tcagaactcc ataaatatta aactaaactg tattgttatt agtagaaggc   1080

taattgtaat gaagacatta ataaagatga aataaactta ttactttaaa ggaaaggatt   1140

tggagaattg aactcacaaa ctgatgttat atactcaata gcttaaactc atgataatgc   1200

tgcgatgtgt ggttttgctt gattttgtat tttatttggg catctggaat tgacacacca   1260

ttacattctg tttgcaggat tttttttgta accatgaaat tgaacatttc caaattataa   1320

actatgttaa tacctataaa atatatagcc aggaaccatt tatcatcaag aaaagtgtaa   1380

gaaattattt ttgagatgta atttaagatt gttttatgta aaaggaaaat cttgtatggc   1440

atcgaatagc cttaatgaat ttaattcttt cacaaaaatg atttcaaatt atcctagagt   1500

ataacatttt tatcaaagat attatttccg gagttcttct ttctttcttt tttttttttt   1560

tttagtaatt tagcaaaaac attactgttc taatgctgaa gtgacttttg ccagtgccat   1620

gtccaggtgg tgaggtataa gttacttgct cttagcattt ggtctgattt ttttgctttg   1680

tggacacctt tgagagtatc cacaaagcaa tgtctcaggt gtggacacct gagagcatgt   1740

tttagaaagc tttgtaccct gtcttgtggc aggaaagaaa gaacaggggt tttacataag   1800

gaaataagtc ctaggaaatt agtcaacgca aattgcattt gcctttgtac cttaccacag   1860

tcttatattg ttttttaaac tctgccatga aatttggaga catgactgtg aaattcctaa   1920

cttactatct tacaaagcca gtagctaatt tgttgctcta tgtatgatcc tgttacaagt   1980

ccagtttgca attcatttgt ttcctagaac acagaagggt accagtaata cactaaatgt   2040

tcaaggtgtg tagagaaata atatggaatt agcagctatg actccaacag acaggattgt   2100

gtgagcagct gaaaggagca aaaaagaact cagtgtaaga gaaggcacat acatagttaa   2160

gaatactaaa gtatttttaa aaatcaagga agaaataaat gttacacaat ttgcattgga   2220

ataaatagat ctatttagtc ctacaaatca ggagtggtgt agagacatcc aaatttaaag   2280

aaaaaaaaac acaaaacaga atgttaaaaa tgtatgcaga tttatggata ttatcaatga   2340

gaagacatag catgtaactt ctcctatatc tctactgtcc agcatgtatt gttccaaata   2400

tgactcccta aaatatatac actttgcaga agctctaggc cctcacctca aaccttgcca   2460

ttggttgccg tatttcaagg tcaatatagt ttccctcact ttacacaatc attattcttc   2520

aatagtggac catatccttc accaggtatc ctatttctgt tatctagagg ttagcagaaa   2580

atgaaatgaa ggaatttccc taagcagttg ggaagaacaa attgtatgca tgtaggcaaa   2640

gattttgaag atacatttgc aagagatatt tgtttaacca aaatatttgg aaagtaacaa   2700

ataaagacat ttaaattttc taaaaatgga cttgctcttc taggaaaaga atacccctgg   2760

ggcaaaaata taactctagc tgtatttctt cttgtcactc ttgattcaac ttgattataa   2820

atacacctgt cactaccaga accaaaaaaa aaaaaaaaaa a                       2861


<210>  280
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  280

Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe 
1               5                   10                  15      


Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp 
            20                  25                  30          


Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro 
        35                  40                  45              


Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr 
    50                  55                  60                  


Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr 
65                  70                  75                  80  


Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile 
                85                  90                  95      


Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe 
            100                 105                 110         


Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys 
        115                 120                 125             


Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys 
    130                 135                 140                 


Met Tyr Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val 
                165                 170                 175     


Asn Gln Asp Ser Thr 
            180     


<210>  281
<211>  2817
<212>  DNA
<213>  Homosapiens

<400>  281
atggctgcgg cgatagccag ctccttgatc cggcagaagc ggcaggcgag ggagtccaac     60

agcgaccgag tgtcggcctc caagcgccgc tccagcccca gcaaagacgg gcgctccctg    120

tgcgagaggc acgtcctcgg ggtgttcagc aaagtgcgct tctgcagcgg ccgcaagagg    180

ccggtgaggc ggagaccaga accccagctc aaagggattg tgacaaggtt attcagccag    240

cagggatact tcctgcagat gcacccagat ggtaccattg atgggaccaa ggacgaaaac    300

agcgactaca ctctcttcaa tctaattccc gtgggcctgc gtgtagtggc catccaagga    360

gtgaaggcta gcctctatgt ggccatgaat ggtgaaggct atctctacag ttcagatgtt    420

ttcactccag aatgcaaatt caaggaatct gtgtttgaaa actactatgt gatctattct    480

tccacactgt accgccagca agaatcaggc cgagcttggt ttctgggact caataaagaa    540

ggtcaaatta tgaaggggaa cagagtgaag aaaaccaagc cctcatcaca ttttgtaccg    600

aaacctattg aagtgtgtat gtacagagaa ccatcgctac atgaaattgg agaaaaacaa    660

gggcgttcaa ggaaaagttc tggaacacca accatgaatg gaggcaaagt tgtgaatcaa    720

gattcaacat agctgagaac tctccccttc ttccctctct catcccttcc ccttcccttc    780

cttcccattt acccatttcc ttccagtaaa tccacccaag gagaggaaaa taaaatgaca    840

acgcaagacc tagtggctaa gattctgcac tcaaaatctt cctttgtgta ggacaagaaa    900

attgaaccaa agcttgcttg ttgcaatgtg gtagaaaatt cacgtgcaca aagattagca    960

cacttaaaag caaaggaaaa aataaatcag aactccataa atattaaact aaactgtatt   1020

gttattagta gaaggctaat tgtaatgaag acattaataa agatgaaata aacttattac   1080

tttaaaggaa aggatttgga gaattgaact cacaaactga tgttatatac tcaatagctt   1140

aaactcatga taatgctgcg atgtgtggtt ttgcttgatt ttgtatttta tttgggcatc   1200

tggaattgac acaccattac attctgtttg caggattttt tttgtaacca tgaaattgaa   1260

catttccaaa ttataaacta tgttaatacc tataaaatat atagccagga accatttatc   1320

atcaagaaaa gtgtaagaaa ttatttttga gatgtaattt aagattgttt tatgtaaaag   1380

gaaaatcttg tatggcatcg aatagcctta atgaatttaa ttctttcaca aaaatgattt   1440

caaattatcc tagagtataa catttttatc aaagatatta tttccggagt tcttctttct   1500

ttcttttttt ttttttttta gtaatttagc aaaaacatta ctgttctaat gctgaagtga   1560

cttttgccag tgccatgtcc aggtggtgag gtataagtta cttgctctta gcatttggtc   1620

tgattttttt gctttgtgga cacctttgag agtatccaca aagcaatgtc tcaggtgtgg   1680

acacctgaga gcatgtttta gaaagctttg taccctgtct tgtggcagga aagaaagaac   1740

aggggtttta cataaggaaa taagtcctag gaaattagtc aacgcaaatt gcatttgcct   1800

ttgtacctta ccacagtctt atattgtttt ttaaactctg ccatgaaatt tggagacatg   1860

actgtgaaat tcctaactta ctatcttaca aagccagtag ctaatttgtt gctctatgta   1920

tgatcctgtt acaagtccag tttgcaattc atttgtttcc tagaacacag aagggtacca   1980

gtaatacact aaatgttcaa ggtgtgtaga gaaataatat ggaattagca gctatgactc   2040

caacagacag gattgtgtga gcagctgaaa ggagcaaaaa agaactcagt gtaagagaag   2100

gcacatacat agttaagaat actaaagtat ttttaaaaat caaggaagaa ataaatgtta   2160

cacaatttgc attggaataa atagatctat ttagtcctac aaatcaggag tggtgtagag   2220

acatccaaat ttaaagaaaa aaaaacacaa aacagaatgt taaaaatgta tgcagattta   2280

tggatattat caatgagaag acatagcatg taacttctcc tatatctcta ctgtccagca   2340

tgtattgttc caaatatgac tccctaaaat atatacactt tgcagaagct ctaggccctc   2400

acctcaaacc ttgccattgg ttgccgtatt tcaaggtcaa tatagtttcc ctcactttac   2460

acaatcatta ttcttcaata gtggaccata tccttcacca ggtatcctat ttctgttatc   2520

tagaggttag cagaaaatga aatgaaggaa tttccctaag cagttgggaa gaacaaattg   2580

tatgcatgta ggcaaagatt ttgaagatac atttgcaaga gatatttgtt taaccaaaat   2640

atttggaaag taacaaataa agacatttaa attttctaaa aatggacttg ctcttctagg   2700

aaaagaatac ccctggggca aaaatataac tctagctgta tttcttcttg tcactcttga   2760

ttcaacttga ttataaatac acctgtcact accagaacca aaaaaaaaaa aaaaaaa      2817


<210>  282
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  282

Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Ser Asn Ser Asp Arg Val Ser Ala Ser Lys Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asp Gly Arg Ser Leu Cys Glu Arg His Val Leu Gly Val 
        35                  40                  45              


Phe Ser Lys Val Arg Phe Cys Ser Gly Arg Lys Arg Pro Val Arg Arg 
    50                  55                  60                  


Arg Pro Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe Ser Gln 
65                  70                  75                  80  


Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp Gly Thr 
                85                  90                  95      


Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly 
            100                 105                 110         


Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr Val Ala 
        115                 120                 125             


Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr Pro Glu 
    130                 135                 140                 


Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser 
145                 150                 155                 160 


Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly 
                165                 170                 175     


Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys Lys Thr 
            180                 185                 190         


Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys Met Tyr 
        195                 200                 205             


Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg Ser Arg 
    210                 215                 220                 


Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val Asn Gln 
225                 230                 235                 240 


Asp Ser Thr 
            


<210>  283
<211>  750
<212>  DNA
<213>  Homosapiens

<400>  283
atgcggggcc cgaacccgcg ccccccgcac cgtgtcagga ttggagaccg ctcgggggct     60

ggtgtggccc gggctcgacc tcccaccctg gagcctctcc ttctccgcct agggcgagag    120

gaggggaggg tccaggggcg ccaccggtcc cgactggcgg gacgcgcgtt gagtgcagag    180

agctttcaaa caaccgatga gagtctgagc agccattcag aaaaatgggg aatgctcatg    240

gactgtgtgg taatgagaga ccaaaacacc aagtgctcca ggggctttgg gtttgtcaca    300

tggaggaggt ggatgcagcc atggatgcaa ggctacataa agtggatgag agttgtaaaa    360

ccaaagagag ctgtctcaag agaagattct caaagaccag gtgcctactt aactgtgaaa    420

aagatatttg ttggtggcat taaagaagac actgaagaac atcacctaag agattatttt    480

gaacagtatg ggaaaattga agtgattgaa atcatgactg accaaggcag tggcaagaaa    540

aggggctttg cctttatttt ggacccacaa agggaggaaa ctttggaggc agaagctctg    600

gcccctaacg tgggggaggc caatactttg ccaaaccacg aaaccaaggt ggctatggta    660

gttctggtag cagcactagc tatagcagtg gcagatttca attcctgcca ggaaagaaaa    720

tttcacagga gaggagagcc agagaagtga                                     750


<210>  284
<211>  249
<212>  PRT
<213>  Homosapiens

<400>  284

Met Arg Gly Pro Asn Pro Arg Pro Pro His Arg Val Arg Ile Gly Asp 
1               5                   10                  15      


Arg Ser Gly Ala Gly Val Ala Arg Ala Arg Pro Pro Thr Leu Glu Pro 
            20                  25                  30          


Leu Leu Leu Arg Leu Gly Arg Glu Glu Gly Arg Val Gln Gly Arg His 
        35                  40                  45              


Arg Ser Arg Leu Ala Gly Arg Ala Leu Ser Ala Glu Ser Phe Gln Thr 
    50                  55                  60                  


Thr Asp Glu Ser Leu Ser Ser His Ser Glu Lys Trp Gly Met Leu Met 
65                  70                  75                  80  


Asp Cys Val Val Met Arg Asp Gln Asn Thr Lys Cys Ser Arg Gly Phe 
                85                  90                  95      


Gly Phe Val Thr Trp Arg Arg Trp Met Gln Pro Trp Met Gln Gly Tyr 
            100                 105                 110         


Ile Lys Trp Met Arg Val Val Lys Pro Lys Arg Ala Val Ser Arg Glu 
        115                 120                 125             


Asp Ser Gln Arg Pro Gly Ala Tyr Leu Thr Val Lys Lys Ile Phe Val 
    130                 135                 140                 


Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe 
145                 150                 155                 160 


Glu Gln Tyr Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Gln Gly 
                165                 170                 175     


Ser Gly Lys Lys Arg Gly Phe Ala Phe Ile Leu Asp Pro Gln Arg Glu 
            180                 185                 190         


Glu Thr Leu Glu Ala Glu Ala Leu Ala Pro Asn Val Gly Glu Ala Asn 
        195                 200                 205             


Thr Leu Pro Asn His Glu Thr Lys Val Ala Met Val Val Leu Val Ala 
    210                 215                 220                 


Ala Leu Ala Ile Ala Val Ala Asp Phe Asn Ser Cys Gln Glu Arg Lys 
225                 230                 235                 240 


Phe His Arg Arg Gly Glu Pro Glu Lys 
                245                 


<210>  285
<211>  3097
<212>  DNA
<213>  Homosapiens

<400>  285
ggcctactgg ggtgtatgtc cgctggattg tgaggcccgg gatctgggct ccgccgtggt     60

gcagaaatgc tgtgccggct cggcggtcgg tggctgcggc cgctccctgc cctgcagctt    120

tgggctaggg acctgccgct tgcgccggtt cctacgagcg gcgccaagcg ccccactctc    180

ccagtgtggg cagtggcacc agtctctgca gtacatgcga acggctggta cgaggccctg    240

gccgcgtctt cgccggtgcg ggttgcggag gaagtactgc tcggcgtgca cgccgccacg    300

ggcctgccct ggtggggcag cattctgctc tccaccgtgg ccttacgggg tgctgtcacg    360

ctgcctttgg cagcctacca gcactacatc ctggccaagg tggaaaattt gcagccagaa    420

ataaaaacta ttgccaggca tcttaaccaa gaagttgcag ttcgtgcaaa tcagttgggg    480

tggtccaaaa gagatgccag gctcacttat ctaaagaata tgaggaggct aatttcagag    540

ctatatgtgc gagataactg ccaccctttc aaagccactg tgttggtttg gattcagctt    600

ccaatgtgga tcttcatgtc ttttgctctc cggaatttaa gcacgggggc agcacattca    660

gaaggttttt ctgttcagga acagttagct actggtggaa ttctgtggtt tcctgacctc    720

actgcacctg actccacttg gattctgcct atctctgttg gcgtcatcaa tttgttaata    780

gtggagattt gtgctctaca aaaaattgga atgtctcgtt ttcagacgta tattacgtac    840

tttgtccgtg caatgtcggt gttgatgata ccaattgctg caacggtacc ctcatcaatt    900

gttctctact ggttatgctc cagcttcgtg ggcctttcac agaatttgct gctgcgttct    960

cctggatttc gccaactttg ccgaatacca tcgaccaagt cagattcaga aactccttat   1020

aaagacatat ttgctgcctt taataccaag ttcatttcaa gaaaatgaca tattttccaa   1080

taattttgaa acagttgcag gagtcactat catctaaatg tatttagact tagaaattca   1140

gatgttactt gatttccttt tatttaaaat cattaacttc atgaaatatt gtaggttaag   1200

atgtaatcca gaccaggcac agtggctcat gcctgtaatc ccagcacttt gggaggtcga   1260

ggtgggtgga tcacctgagg tctggagttt gagaccagcc tggccaacat ggtgaaaccc   1320

tgtctgtact aaaataacaa aaaaattagc tgggcttagt ggcaggtgcc tgtaatccca   1380

gctacttggg aggctgaggc aggagaatcg cttgaacctg gaatacagag gtttcagtga   1440

gctgagatca ccccattgca ctccagcctg gacaacaaga gtgaaacgct atcaaagaaa   1500

aaaaaaagat gtaatccaga tatatttgac agtaattaaa atcttttaaa tgttataaat   1560

gcagtatgtt tgtgaaagta ttagaataga accaaagtgc ctgtctctgt ttataaagtt   1620

acagtttgtt agagctacca gaactttgga gaatagggtt agctactgaa tgatggcaag   1680

ttaaactaaa caatactgca tattactgtt ttgtaaaata agaggatcag tgagatgatt   1740

catgtttttt ttttttgaga tggagtctca ctgtgtcacc caggctggag tgcagtggcg   1800

caatctcagc tcactgcaac ctccatctcc cggattccag cgattttcct gcctcagcct   1860

ccaagtatct gggattgcag gtgcacacca ccacgcccag ctaatttttg tatttttggt   1920

agagatgggg tttcaccatg ttggacaggc tggtctggaa ctgctgacct caactaatcc   1980

accctccttg gcctcccata gtgctgggat tacaggcatg agccacctca cccagcattt   2040

tttttttttt aattttttta atgagacaga gtctctctct gtcacctagg ctggagtgca   2100

gtggcacgat ctcggctcac tgcaacctct gcctcccgtg ttcaagcaat tctcctacct   2160

cagcctactg ggtagctggg actacagggg tgcaccacca tgcccagcta agttttgtat   2220

ttttagtaga gatgggattt caccatgttg gctaggctgg tcttgaactc ctggcctcaa   2280

gtgatctgcc caccttggcc tcccaaagtg ctgggattac aggcgtgagc cactgtgccc   2340

agctgagatg tttcttatta ttttggaggt ggagaggatt ttagacctct ttgagcatct   2400

gaaaaaaggc tatatatgta tggttttctc ttcagaaaaa tcttaagact cacaatacgg   2460

ggacttcctt gttaccagga agattttctg gcaattccta gttaataaat cttattctaa   2520

tggaacatac attgatcttg agttaatgcg tggttgaaaa aaaaaagcgg gggcaacttg   2580

aaatatatgc agtaaagtag tccatgcata caagtcccta acatggtaga tgatgttgcc   2640

tcccggccct gctcagaaag aatacaaaaa gtgtacattc ctttttctat aatttaagaa   2700

gtctggaata cagagtgtaa cactgtgtac tgctagcacc caaagtggaa aatcttaagc   2760

attcagattg tttagtcaaa gaagaaaacc agaagggcag ttgcctattg aggtgatttt   2820

aaacctgttt atttgtaagg attaagtacc ctaataggct taaactatga tagaggttta   2880

atacagaaaa aattgacagg tattataaat tgtggatcca gttacttgct tatttaattt   2940

gtaaagaggt aaaattagct ctggttgaga tatcaagtat ggcaggtatt tgagaaggct   3000

ataaatcata attttcattt agttaaaata tggacctgat tctgggaaac cctatcattc   3060

catctcaatg ttttacaata aaataaaaac taaagtg                            3097


<210>  286
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  286

Met Leu Cys Arg Leu Gly Gly Arg Trp Leu Arg Pro Leu Pro Ala Leu 
1               5                   10                  15      


Gln Leu Trp Ala Arg Asp Leu Pro Leu Ala Pro Val Pro Thr Ser Gly 
            20                  25                  30          


Ala Lys Arg Pro Thr Leu Pro Val Trp Ala Val Ala Pro Val Ser Ala 
        35                  40                  45              


Val His Ala Asn Gly Trp Tyr Glu Ala Leu Ala Ala Ser Ser Pro Val 
    50                  55                  60                  


Arg Val Ala Glu Glu Val Leu Leu Gly Val His Ala Ala Thr Gly Leu 
65                  70                  75                  80  


Pro Trp Trp Gly Ser Ile Leu Leu Ser Thr Val Ala Leu Arg Gly Ala 
                85                  90                  95      


Val Thr Leu Pro Leu Ala Ala Tyr Gln His Tyr Ile Leu Ala Lys Val 
            100                 105                 110         


Glu Asn Leu Gln Pro Glu Ile Lys Thr Ile Ala Arg His Leu Asn Gln 
        115                 120                 125             


Glu Val Ala Val Arg Ala Asn Gln Leu Gly Trp Ser Lys Arg Asp Ala 
    130                 135                 140                 


Arg Leu Thr Tyr Leu Lys Asn Met Arg Arg Leu Ile Ser Glu Leu Tyr 
145                 150                 155                 160 


Val Arg Asp Asn Cys His Pro Phe Lys Ala Thr Val Leu Val Trp Ile 
                165                 170                 175     


Gln Leu Pro Met Trp Ile Phe Met Ser Phe Ala Leu Arg Asn Leu Ser 
            180                 185                 190         


Thr Gly Ala Ala His Ser Glu Gly Phe Ser Val Gln Glu Gln Leu Ala 
        195                 200                 205             


Thr Gly Gly Ile Leu Trp Phe Pro Asp Leu Thr Ala Pro Asp Ser Thr 
    210                 215                 220                 


Trp Ile Leu Pro Ile Ser Val Gly Val Ile Asn Leu Leu Ile Val Glu 
225                 230                 235                 240 


Ile Cys Ala Leu Gln Lys Ile Gly Met Ser Arg Phe Gln Thr Tyr Ile 
                245                 250                 255     


Thr Tyr Phe Val Arg Ala Met Ser Val Leu Met Ile Pro Ile Ala Ala 
            260                 265                 270         


Thr Val Pro Ser Ser Ile Val Leu Tyr Trp Leu Cys Ser Ser Phe Val 
        275                 280                 285             


Gly Leu Ser Gln Asn Leu Leu Leu Arg Ser Pro Gly Phe Arg Gln Leu 
    290                 295                 300                 


Cys Arg Ile Pro Ser Thr Lys Ser Asp Ser Glu Thr Pro Tyr Lys Asp 
305                 310                 315                 320 


Ile Phe Ala Ala Phe Asn Thr Lys Phe Ile Ser Arg Lys 
                325                 330             


<210>  287
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  287
gaggcggtgg cggcggaggc ggcaccgatt gctgtgtcgg ccccagtgcg gccgaagtcg     60

cggtagagcg tagccccacg cccctccccc gtccgcgccc tccctctttc cctggggatg    120

gagaaggcga cggttccggt ggcggcggcg acggctgcag aaggagaagg gagccccccg    180

gcggtggcgg ctgtggcggg cccccccgcg gcggcggagg tcggcggcgg cgttggcggc    240

agcagcagag ctcgctcggc ctcgtctcct cgtgggatgg tgcgagtctg cgacctgctc    300

ctgaagaaga agccgccgca gcagcagcac cacaaggcca agcgtaaccg gacttgccga    360

ccccccagca gcagcgaaag cagcagcgac agcgacaaca gcggcggcgg tggaggcggc    420

ggtggaggcg gaggtggcgg cggcggcacc agcagtaaca acagcgagga agaagaggac    480

gacgacgacg aggaagagga ggtttctgag gtggagtctt tcattttgga tcaggatgat    540

ttggaaaatc caatgctgga aacagcttcc aagttgctct tatcaggtac tgctgatggt    600

gcagacctca ggacagtaga tccagaaaca caggctagac tggaagcttt actagaagct    660

gcaggaatag gaaaattgtc cacggctgat ggtaaagcct ttgcagatcc tgaagtactt    720

cggaggttga catcgtctgt tagttgtgcg ttggatgaag ctgctgctgc acttacccgt    780

atgagagctg aaagcacagc aaatgcaggg cagtcggaca accgcagttt ggcagaagcc    840

tgttcagaag gagatgtaaa tgctgtgcga aagttactca ttgaagggcg aagtgtaaat    900

gaacacacag aggaagggga gagcctcctt tgtttagctt gttctgctgg atactatgag    960

cttgcacagg ttttgttggc aatgcatgca aatgtggaag ataggggaat caaaggtgac   1020

attacacctt taatggctgc tgctaatgga ggacatgtca aaattgtgaa gttgctgcta   1080

gctcataaag cagatgttaa tgcacagtct tcaacaggca atacagcact tacatatgct   1140

tgtgctggag gctatgtaga tgttgtaaag gtgctcttgg aatccggtgc tagtattgag   1200

gaccataatg aaaatggtca tacccctctt atggaagctg gaagtgctgg acatgtggaa   1260

gtagccagat tgctgctaga aaatggggct ggcattaata cgcattctaa tgaatttaaa   1320

gagagtgccc ttaccttagc ttgttacaaa ggacacttag agatggtgcg atttcttttg   1380

gaagcaggcg cggatcaaga gcataaaaca gatgaaatgc acactgctct gatggaggct   1440

tgcatggatg gccatgttga agtagctagg ttacttcttg acagcggtgc ccaagtgaac   1500

atgcctgctg attcatttga gtcaccatta actttggctg catgtggtgg gcatgtggaa   1560

cttgcggctt tacttattga aagaggagct agcctggaag aggtcaatga tgaaggttat   1620

acaccattga tggaagcagc tcgagaagga catgaagaaa tggtggcatt acttcttggt   1680

caaggagcaa atatcaatgc acagacagaa gaaactcaag aaactgcctt gactctggct   1740

tgctgtggag gctttctgga agtggcagac tttctaatta aggcaggagc cgatatagaa   1800

ctagggtgtt ctaccccttt aatggaagct gctcaagagg gtcatttgga gttagttaaa   1860

tacttattag ctgcaggagc taacgttcat gcaacaacag caacagggga tacagcacta   1920

acatatgcct gtgaaaatgg tcatactgat gtagcagatg tcttacttca ggcaggcgca   1980

gatctggaac atgaatctga aggtggaaga actcctttaa tgaaagctgc aagagctggt   2040

catgtttgta ctgttcagtt cttaattagt aaaggagcga atgtgaatag aaccacagct   2100

aataatgacc atactgtact gtccctggct tgtgcagggg gtcatctggc agtggtggaa   2160

ctacttttgg ctcatggggc agatcctact caccgtttga aagatggctc aactatgttg   2220

atagaagcag caaaaggtgg ccatacaagt gttgtttgct atctcttgga ttatcctaat   2280

aacttgcttt cagcccctcc accagatgtc actcagttaa ctcccccatc ccacgattta   2340

aatagggctc ctcgtgtacc agttcaagca ctgcccatgg ttgttccacc tcaggagcct   2400

gacaaaccac ctgccaatgt tgccaccact cttcccatca ggaataaagc agtcagtgga   2460

agagcatctg caatgtcaaa cactcctacc cacagtattg ctgcatccat ttcccaacct   2520

cagactccaa ctccaagtcc tatcatctct ccttcagcca tgcttcctat ctaccctgcc   2580

attgatattg atgcacagac tgagagtaat catgacacgg cgctaacact tgcctgtgct   2640

ggtggccacg aggaactggt acaaacactg ctagagagag gagctagtat agagcaccga   2700

gacaagaaag gttttactcc actcatcttg gctgccacag ctggtcatgt tggtgttgtg   2760

gaaatattgc tggacaatgg tgcagacatt gaagcccagt ctgaaagaac caaggacaca   2820

ccactctcct tggcttgttc tgggggaaga caggaggtgg tggagctatt gttagctcga   2880

ggggcaaata aagagcacag gaatgtttct gattacacac ctctaagtct ggctgcttct   2940

ggtggctatg tgaacatcat caaaatatta ctaaatgcag gagctgagat taactctaga   3000

actggtagca aattgggcat ctctcctctg atgttagcag ctatgaatgg gcatacagct   3060

gctgttaagc tcctgttaga catgggctct gacataaatg ctcagataga aaccaatcgg   3120

aacactgccc ttactttagc ctgcttccaa ggaagaactg aagtggttag tcttctgctt   3180

gatagaaaag caaatgttga acacagagct aagactggtc tcacaccact aatggaagct   3240

gcctctggtg gatatgcgga ggtgggccga gttcttttgg ataaaggtgc tgatgttaat   3300

gcccctccag ttccctcctc aagagataca gctttaacca tagcagcaga taaagggcat   3360

tacaaattct gtgagcttct tattggcagg ggagctcata ttgatgtacg taacaagaag   3420

gggaacactc cattgtggct agcagcaaat ggtggacacc tcgatgtggt tcagttactg   3480

gtgcaagcag gtgcagatgt ggatgcagca gataaccgca agataactcc tcttatggca   3540

gcatttagaa agggtcatgt gaaggtggtg cgctacttag tcaaagaagt caatcagttt   3600

ccatcagatt ctgaatgtat gagatacata gcaaccatca ctgataagga gatgctgaag   3660

aagtgtcatc tttgtatgga gtcaatagta caagccaaag atagacaggc tgctgaagca   3720

aacaaaaacg ccagcatttt gttagaggag ttagacttgg aaaagttaag ggaagaaagt   3780

cggaggctgg ctttggctgc gaaaagagaa aaaagaaaag agaagagaag gaagaaaaag   3840

gaagaacaaa gaaggaaact agaagaaatt gaagccaaaa ataaagagaa ctttgaactc   3900

caagctgctc aagaaaaaga aaagcttaaa gttgaagatg agcctgaagt cttgacagaa   3960

cctccaagtg ccacaaccac tactaccata ggtatatctg caacctggac aactttggca   4020

ggttctcatg gtaaaagaaa taataccata actacaacca gttcaaagag gaaaaacagg   4080

aaaaataaaa ttactccaga aaacgttcaa attatatttg atgatccact accaatttca   4140

tacagtcagc cagagaaggt gaatggagag tccaagagca gcagtaccag cgagagtggg   4200

gacagtgata acatgaggat ttccagctgc agcgatgaaa gtagtaacag caacagcagt   4260

cgtaagagtg acaatcattc accagctgtg gtcactacca ctgtgagcag caaaaagcag   4320

ccatcagttc ttgttacatt tccaaaggaa gagagaaaat ctgtttctgg caaggcttca   4380

ataaaattgt cagaaactat cagtgaaggg accagtaatt ctctatctac ttgtacaaaa   4440

tctggtccat ctcccctttc ttctccaaat gggaagttaa cagtagcaag tcctaagcgt   4500

gggcaaaaga gggaagaagg atggaaagaa gttgtaagaa ggtcaaagaa agtatctgtt   4560

ccatcaactg tgatatccag agtgattgga agaggaggct gtaatatcaa tgctattcgg   4620

gagtttactg gtgcacacat agatattgat aaacagaaag acaagactgg agaccggata   4680

atcactataa ggggtggcac tgaatcaaca agacaagcaa ctcaattgat taatgctttg   4740

atcaaggatc cagacaaaga aattgatgaa cttattccaa agaatcgttt gaaaagctcc   4800

tcagcaaatt ccaaaatagg gtcatcagca cctaccacca ctgctgctaa cacttcctta   4860

atgggaatta aaatgacaac tgtagctctg tcatcaacat ctcaaactgc cacagcactc   4920

actgtgcctg caatttcttc tgcatccact cacaaaacca ttaagaaccc agtgaataat   4980

gtgaggcctg gttttccagt ttctcttcca ttagcatatc ctcctccaca gtttgcacat   5040

gctttgcttg ctgctcagac tttccagcag atccgtccac caaggttgcc catgacccac   5100

tttggaggta cttttccacc agctcaatcc acttggggtc cgtttcctgt caggcctttg   5160

agccctgcca gagctactaa ctcgcctaag cctcacatgg tgcctcgcca tagcaatcag   5220

aatagcagtg gttctcaggt gaattcagca ggttctttaa cttcaagccc aacaactaca   5280

accagttcat cagcttcaac ggtgcctggt acatctacaa atggcagtcc aagttcacct   5340

tctgtccgaa ggcagctttt tgtcacagtt gtgaagacat ccaatgccac cacaacaaca   5400

gtcacaacca cggcaagcaa caacaacact gcacccacaa atgccacata tcctatgcct   5460

actgccaaag aacactatcc agtatcatcc ccatcttccc catcaccacc agcccagcca   5520

ggaggggttt ctagaaacag ccctttggat tgtggatcag catctccaaa taaagtggca   5580

tcttcctccg aacaggaagc aggtagtcca ccagtagtag aaacaacaaa cactagacct   5640

ccaaacagca gcagttcttc tgggagttca tcagctcatt ctaatcagca acaacctccg   5700

ggatctgttt ctcaggaacc aagaccacct cttcagcagt ctcaggttcc tcccccggaa   5760

gttagaatga ctgttcctcc tttagcaaca agttctgctc cagtggcggt gccttctact   5820

gccccagtga cttaccctat gcctcagaca ccaatgggat gcccccagcc tactcctaaa   5880

atggaaaccc ctgctattag accaccccct catggcacaa ctgcccctca caagaattca   5940

gcttcagtgc aaaattcatc tgttgcagtc ctcagtgtca atcacattaa aagacctcac   6000

agtgttccct cttctgtcca gctaccttcg accttaagta cacaaagtgc ttgtcagaat   6060

tcagtacatc cagcaaataa gcctattgct cccaatttca gtgccccctt accatttggg   6120

ccctttagca cattgtttga aaacagccct acttctgctc atgccttctg gggaggatct   6180

gttgtttcat ctcagtcaac accagaatct atgctatcag gaaaatcctc atatttgcca   6240

aattcagatc ctttacatca gtctgatact tccaaagctc caggttttag accaccatta   6300

cagagacctg ctccaagtcc ctcaggtatt gtcaatatgg actcgccata tggttctgta   6360

acaccttctt caacacattt gggaaacttt gcttcaaaca tttcaggagg tcagatgtac   6420

ggacctgggg caccccttgg aggagcaccc gcagctgcta actttaacag acaacatttt   6480

tccccgctta gtttgttgac tccgtgttca tcagcatcaa atgattcttc tgcacagtca   6540

gtatcctcgg gagttcgtgc accatctcct gccccatcat cagtaccgtt agggtcagaa   6600

aagcccagca atgtgtctca ggacaggaaa gttccagtcc ctattgggac tgaacgttct   6660

gcacgtatca ggcaaactgg aacgtcagct ccatctgtta ttgggagcaa tttgtctaca   6720

tcagtaggac atagtggcat ctggtccttt gaagggattg gtggcaatca agacaaagta   6780

gactggtgta accctgggat gggaaatcct atgatccaca gaccgatgtc tgacccagga   6840

gtattttcac aacatcaagc aatggagcga gatagtacag gaattgtaac tccttctggt   6900

acattccatc agcatgttcc tgcaggctac atggactttc ctaaagttgg gggtatgcct   6960

ttttctgtgt atgggaatgc aatgattcct ccagtagcac ctatccctga tggtgctgga   7020

ggacccatat ttaatggccc tcatgctgca gacccttctt ggaactcact gataaagatg   7080

gtttccagct ccacggaaaa taatggccct caaacggtgt ggactggacc ctgggcacct   7140

cacatgaaca gtgtgcatat gaaccagctt ggctgatgag gatcagcttg ttagcctgca   7200

gattcctttt catttggagg aaatcacaag tggccgaaaa aaaaaattat gctcccaaat   7260

cattctactg atgtgcttga ctgaagtgtg taggcttttt gcagaagatc ttactaactg   7320

acctattttc tgtgaacatt tgtgactgcc cattccccat catcatccgt tttaccttag   7380

ttagcatttt tcttatcatt tttctttttt tctttccctc ttcccctttg gacataactt   7440

tctgttgaag ctgttctttg gctggttggt tttagtactg taaactgctt ctgagcaaac   7500

acggaaattt agcaaaatta tgtaaacttg atcctgaagt tttagaatgg caaataaatg   7560

tacaattgtt tacataacag aaaaggctaa gcagaaagta aatttcaata tgtcagtata   7620

gaggctctac tttatgtaga cttaaattaa tgtgagatat gtaccttcat attcagaaat   7680

ctggatgttt ccttcataca ttaaactatt aataagcata acttttctac tggtgtaatt   7740

taagtataaa gtaaaataat gggcattatc attggatgtt tccccacatt ggcttttaaa   7800

atacccatct tgctttcttt ttggtttatt tgtagcaagg cacatataga agaagaaatt   7860

tctggctttt ccatgttgtt ttattacctt ttctcacttt taaaactaat acagacttat   7920

ctcctcactc ctttttctct ccttaccttt accactaata ccagtaaaat tatctttctg   7980

atagtgaaaa ggttctgtca agattttcac tgtaatggct gctacagaga tggaccatct   8040

tcatcatcac cagtggtttc ttctaattat aaaatgttta aactttctga gaatttaaaa   8100

agccaccact gttcccagtc agcatataca agctcttaat attctgttta ttaaataatt   8160

caatgtacta ttttatattg gatgatattg at                                 8192


<210>  288
<211>  2352
<212>  PRT
<213>  Homosapiens

<400>  288

Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr 
                325                 330                 335     


Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp 
            420                 425                 430         


Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Val Ser Gly Arg Ala Ser 
    770                 775                 780                 


Ala Met Ser Asn Thr Pro Thr His Ser Ile Ala Ala Ser Ile Ser Gln 
785                 790                 795                 800 


Pro Gln Thr Pro Thr Pro Ser Pro Ile Ile Ser Pro Ser Ala Met Leu 
                805                 810                 815     


Pro Ile Tyr Pro Ala Ile Asp Ile Asp Ala Gln Thr Glu Ser Asn His 
            820                 825                 830         


Asp Thr Ala Leu Thr Leu Ala Cys Ala Gly Gly His Glu Glu Leu Val 
        835                 840                 845             


Gln Thr Leu Leu Glu Arg Gly Ala Ser Ile Glu His Arg Asp Lys Lys 
    850                 855                 860                 


Gly Phe Thr Pro Leu Ile Leu Ala Ala Thr Ala Gly His Val Gly Val 
865                 870                 875                 880 


Val Glu Ile Leu Leu Asp Asn Gly Ala Asp Ile Glu Ala Gln Ser Glu 
                885                 890                 895     


Arg Thr Lys Asp Thr Pro Leu Ser Leu Ala Cys Ser Gly Gly Arg Gln 
            900                 905                 910         


Glu Val Val Glu Leu Leu Leu Ala Arg Gly Ala Asn Lys Glu His Arg 
        915                 920                 925             


Asn Val Ser Asp Tyr Thr Pro Leu Ser Leu Ala Ala Ser Gly Gly Tyr 
    930                 935                 940                 


Val Asn Ile Ile Lys Ile Leu Leu Asn Ala Gly Ala Glu Ile Asn Ser 
945                 950                 955                 960 


Arg Thr Gly Ser Lys Leu Gly Ile Ser Pro Leu Met Leu Ala Ala Met 
                965                 970                 975     


Asn Gly His Thr Ala Ala Val Lys Leu Leu Leu Asp Met Gly Ser Asp 
            980                 985                 990         


Ile Asn Ala Gln Ile Glu Thr Asn  Arg Asn Thr Ala Leu  Thr Leu Ala 
        995                 1000                 1005             


Cys Phe  Gln Gly Arg Thr Glu  Val Val Ser Leu Leu  Leu Asp Arg 
    1010                 1015                 1020             


Lys Ala  Asn Val Glu His Arg  Ala Lys Thr Gly Leu  Thr Pro Leu 
    1025                 1030                 1035             


Met Glu  Ala Ala Ser Gly Gly  Tyr Ala Glu Val Gly  Arg Val Leu 
    1040                 1045                 1050             


Leu Asp  Lys Gly Ala Asp Val  Asn Ala Pro Pro Val  Pro Ser Ser 
    1055                 1060                 1065             


Arg Asp  Thr Ala Leu Thr Ile  Ala Ala Asp Lys Gly  His Tyr Lys 
    1070                 1075                 1080             


Phe Cys  Glu Leu Leu Ile Gly  Arg Gly Ala His Ile  Asp Val Arg 
    1085                 1090                 1095             


Asn Lys  Lys Gly Asn Thr Pro  Leu Trp Leu Ala Ala  Asn Gly Gly 
    1100                 1105                 1110             


His Leu  Asp Val Val Gln Leu  Leu Val Gln Ala Gly  Ala Asp Val 
    1115                 1120                 1125             


Asp Ala  Ala Asp Asn Arg Lys  Ile Thr Pro Leu Met  Ala Ala Phe 
    1130                 1135                 1140             


Arg Lys  Gly His Val Lys Val  Val Arg Tyr Leu Val  Lys Glu Val 
    1145                 1150                 1155             


Asn Gln  Phe Pro Ser Asp Ser  Glu Cys Met Arg Tyr  Ile Ala Thr 
    1160                 1165                 1170             


Ile Thr  Asp Lys Glu Met Leu  Lys Lys Cys His Leu  Cys Met Glu 
    1175                 1180                 1185             


Ser Ile  Val Gln Ala Lys Asp  Arg Gln Ala Ala Glu  Ala Asn Lys 
    1190                 1195                 1200             


Asn Ala  Ser Ile Leu Leu Glu  Glu Leu Asp Leu Glu  Lys Leu Arg 
    1205                 1210                 1215             


Glu Glu  Ser Arg Arg Leu Ala  Leu Ala Ala Lys Arg  Glu Lys Arg 
    1220                 1225                 1230             


Lys Glu  Lys Arg Arg Lys Lys  Lys Glu Glu Gln Arg  Arg Lys Leu 
    1235                 1240                 1245             


Glu Glu  Ile Glu Ala Lys Asn  Lys Glu Asn Phe Glu  Leu Gln Ala 
    1250                 1255                 1260             


Ala Gln  Glu Lys Glu Lys Leu  Lys Val Glu Asp Glu  Pro Glu Val 
    1265                 1270                 1275             


Leu Thr  Glu Pro Pro Ser Ala  Thr Thr Thr Thr Thr  Ile Gly Ile 
    1280                 1285                 1290             


Ser Ala  Thr Trp Thr Thr Leu  Ala Gly Ser His Gly  Lys Arg Asn 
    1295                 1300                 1305             


Asn Thr  Ile Thr Thr Thr Ser  Ser Lys Arg Lys Asn  Arg Lys Asn 
    1310                 1315                 1320             


Lys Ile  Thr Pro Glu Asn Val  Gln Ile Ile Phe Asp  Asp Pro Leu 
    1325                 1330                 1335             


Pro Ile  Ser Tyr Ser Gln Pro  Glu Lys Val Asn Gly  Glu Ser Lys 
    1340                 1345                 1350             


Ser Ser  Ser Thr Ser Glu Ser  Gly Asp Ser Asp Asn  Met Arg Ile 
    1355                 1360                 1365             


Ser Ser  Cys Ser Asp Glu Ser  Ser Asn Ser Asn Ser  Ser Arg Lys 
    1370                 1375                 1380             


Ser Asp  Asn His Ser Pro Ala  Val Val Thr Thr Thr  Val Ser Ser 
    1385                 1390                 1395             


Lys Lys  Gln Pro Ser Val Leu  Val Thr Phe Pro Lys  Glu Glu Arg 
    1400                 1405                 1410             


Lys Ser  Val Ser Gly Lys Ala  Ser Ile Lys Leu Ser  Glu Thr Ile 
    1415                 1420                 1425             


Ser Glu  Gly Thr Ser Asn Ser  Leu Ser Thr Cys Thr  Lys Ser Gly 
    1430                 1435                 1440             


Pro Ser  Pro Leu Ser Ser Pro  Asn Gly Lys Leu Thr  Val Ala Ser 
    1445                 1450                 1455             


Pro Lys  Arg Gly Gln Lys Arg  Glu Glu Gly Trp Lys  Glu Val Val 
    1460                 1465                 1470             


Arg Arg  Ser Lys Lys Val Ser  Val Pro Ser Thr Val  Ile Ser Arg 
    1475                 1480                 1485             


Val Ile  Gly Arg Gly Gly Cys  Asn Ile Asn Ala Ile  Arg Glu Phe 
    1490                 1495                 1500             


Thr Gly  Ala His Ile Asp Ile  Asp Lys Gln Lys Asp  Lys Thr Gly 
    1505                 1510                 1515             


Asp Arg  Ile Ile Thr Ile Arg  Gly Gly Thr Glu Ser  Thr Arg Gln 
    1520                 1525                 1530             


Ala Thr  Gln Leu Ile Asn Ala  Leu Ile Lys Asp Pro  Asp Lys Glu 
    1535                 1540                 1545             


Ile Asp  Glu Leu Ile Pro Lys  Asn Arg Leu Lys Ser  Ser Ser Ala 
    1550                 1555                 1560             


Asn Ser  Lys Ile Gly Ser Ser  Ala Pro Thr Thr Thr  Ala Ala Asn 
    1565                 1570                 1575             


Thr Ser  Leu Met Gly Ile Lys  Met Thr Thr Val Ala  Leu Ser Ser 
    1580                 1585                 1590             


Thr Ser  Gln Thr Ala Thr Ala  Leu Thr Val Pro Ala  Ile Ser Ser 
    1595                 1600                 1605             


Ala Ser  Thr His Lys Thr Ile  Lys Asn Pro Val Asn  Asn Val Arg 
    1610                 1615                 1620             


Pro Gly  Phe Pro Val Ser Leu  Pro Leu Ala Tyr Pro  Pro Pro Gln 
    1625                 1630                 1635             


Phe Ala  His Ala Leu Leu Ala  Ala Gln Thr Phe Gln  Gln Ile Arg 
    1640                 1645                 1650             


Pro Pro  Arg Leu Pro Met Thr  His Phe Gly Gly Thr  Phe Pro Pro 
    1655                 1660                 1665             


Ala Gln  Ser Thr Trp Gly Pro  Phe Pro Val Arg Pro  Leu Ser Pro 
    1670                 1675                 1680             


Ala Arg  Ala Thr Asn Ser Pro  Lys Pro His Met Val  Pro Arg His 
    1685                 1690                 1695             


Ser Asn  Gln Asn Ser Ser Gly  Ser Gln Val Asn Ser  Ala Gly Ser 
    1700                 1705                 1710             


Leu Thr  Ser Ser Pro Thr Thr  Thr Thr Ser Ser Ser  Ala Ser Thr 
    1715                 1720                 1725             


Val Pro  Gly Thr Ser Thr Asn  Gly Ser Pro Ser Ser  Pro Ser Val 
    1730                 1735                 1740             


Arg Arg  Gln Leu Phe Val Thr  Val Val Lys Thr Ser  Asn Ala Thr 
    1745                 1750                 1755             


Thr Thr  Thr Val Thr Thr Thr  Ala Ser Asn Asn Asn  Thr Ala Pro 
    1760                 1765                 1770             


Thr Asn  Ala Thr Tyr Pro Met  Pro Thr Ala Lys Glu  His Tyr Pro 
    1775                 1780                 1785             


Val Ser  Ser Pro Ser Ser Pro  Ser Pro Pro Ala Gln  Pro Gly Gly 
    1790                 1795                 1800             


Val Ser  Arg Asn Ser Pro Leu  Asp Cys Gly Ser Ala  Ser Pro Asn 
    1805                 1810                 1815             


Lys Val  Ala Ser Ser Ser Glu  Gln Glu Ala Gly Ser  Pro Pro Val 
    1820                 1825                 1830             


Val Glu  Thr Thr Asn Thr Arg  Pro Pro Asn Ser Ser  Ser Ser Ser 
    1835                 1840                 1845             


Gly Ser  Ser Ser Ala His Ser  Asn Gln Gln Gln Pro  Pro Gly Ser 
    1850                 1855                 1860             


Val Ser  Gln Glu Pro Arg Pro  Pro Leu Gln Gln Ser  Gln Val Pro 
    1865                 1870                 1875             


Pro Pro  Glu Val Arg Met Thr  Val Pro Pro Leu Ala  Thr Ser Ser 
    1880                 1885                 1890             


Ala Pro  Val Ala Val Pro Ser  Thr Ala Pro Val Thr  Tyr Pro Met 
    1895                 1900                 1905             


Pro Gln  Thr Pro Met Gly Cys  Pro Gln Pro Thr Pro  Lys Met Glu 
    1910                 1915                 1920             


Thr Pro  Ala Ile Arg Pro Pro  Pro His Gly Thr Thr  Ala Pro His 
    1925                 1930                 1935             


Lys Asn  Ser Ala Ser Val Gln  Asn Ser Ser Val Ala  Val Leu Ser 
    1940                 1945                 1950             


Val Asn  His Ile Lys Arg Pro  His Ser Val Pro Ser  Ser Val Gln 
    1955                 1960                 1965             


Leu Pro  Ser Thr Leu Ser Thr  Gln Ser Ala Cys Gln  Asn Ser Val 
    1970                 1975                 1980             


His Pro  Ala Asn Lys Pro Ile  Ala Pro Asn Phe Ser  Ala Pro Leu 
    1985                 1990                 1995             


Pro Phe  Gly Pro Phe Ser Thr  Leu Phe Glu Asn Ser  Pro Thr Ser 
    2000                 2005                 2010             


Ala His  Ala Phe Trp Gly Gly  Ser Val Val Ser Ser  Gln Ser Thr 
    2015                 2020                 2025             


Pro Glu  Ser Met Leu Ser Gly  Lys Ser Ser Tyr Leu  Pro Asn Ser 
    2030                 2035                 2040             


Asp Pro  Leu His Gln Ser Asp  Thr Ser Lys Ala Pro  Gly Phe Arg 
    2045                 2050                 2055             


Pro Pro  Leu Gln Arg Pro Ala  Pro Ser Pro Ser Gly  Ile Val Asn 
    2060                 2065                 2070             


Met Asp  Ser Pro Tyr Gly Ser  Val Thr Pro Ser Ser  Thr His Leu 
    2075                 2080                 2085             


Gly Asn  Phe Ala Ser Asn Ile  Ser Gly Gly Gln Met  Tyr Gly Pro 
    2090                 2095                 2100             


Gly Ala  Pro Leu Gly Gly Ala  Pro Ala Ala Ala Asn  Phe Asn Arg 
    2105                 2110                 2115             


Gln His  Phe Ser Pro Leu Ser  Leu Leu Thr Pro Cys  Ser Ser Ala 
    2120                 2125                 2130             


Ser Asn  Asp Ser Ser Ala Gln  Ser Val Ser Ser Gly  Val Arg Ala 
    2135                 2140                 2145             


Pro Ser  Pro Ala Pro Ser Ser  Val Pro Leu Gly Ser  Glu Lys Pro 
    2150                 2155                 2160             


Ser Asn  Val Ser Gln Asp Arg  Lys Val Pro Val Pro  Ile Gly Thr 
    2165                 2170                 2175             


Glu Arg  Ser Ala Arg Ile Arg  Gln Thr Gly Thr Ser  Ala Pro Ser 
    2180                 2185                 2190             


Val Ile  Gly Ser Asn Leu Ser  Thr Ser Val Gly His  Ser Gly Ile 
    2195                 2200                 2205             


Trp Ser  Phe Glu Gly Ile Gly  Gly Asn Gln Asp Lys  Val Asp Trp 
    2210                 2215                 2220             


Cys Asn  Pro Gly Met Gly Asn  Pro Met Ile His Arg  Pro Met Ser 
    2225                 2230                 2235             


Asp Pro  Gly Val Phe Ser Gln  His Gln Ala Met Glu  Arg Asp Ser 
    2240                 2245                 2250             


Thr Gly  Ile Val Thr Pro Ser  Gly Thr Phe His Gln  His Val Pro 
    2255                 2260                 2265             


Ala Gly  Tyr Met Asp Phe Pro  Lys Val Gly Gly Met  Pro Phe Ser 
    2270                 2275                 2280             


Val Tyr  Gly Asn Ala Met Ile  Pro Pro Val Ala Pro  Ile Pro Asp 
    2285                 2290                 2295             


Gly Ala  Gly Gly Pro Ile Phe  Asn Gly Pro His Ala  Ala Asp Pro 
    2300                 2305                 2310             


Ser Trp  Asn Ser Leu Ile Lys  Met Val Ser Ser Ser  Thr Glu Asn 
    2315                 2320                 2325             


Asn Gly  Pro Gln Thr Val Trp  Thr Gly Pro Trp Ala  Pro His Met 
    2330                 2335                 2340             


Asn Ser  Val His Met Asn Gln  Leu Gly 
    2345                 2350         


<210>  289
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  289
gaggcggtgg cggcggaggc ggcaccgatt gctgtgtcgg ccccagtgcg gccgaagtcg     60

cggtagagcg tagccccacg cccctccccc gtccgcgccc tccctctttc cctggggatg    120

gagaaggcga cggttccggt ggcggcggcg acggctgcag aaggagaagg gagccccccg    180

gcggtggcgg ctgtggcggg cccccccgcg gcggcggagg tcggcggcgg cgttggcggc    240

agcagcagag ctcgctcggc ctcgtctcct cgtgggatgg tgcgagtctg cgacctgctc    300

ctgaagaaga agccgccgca gcagcagcac cacaaggcca agcgtaaccg gacttgccga    360

ccccccagca gcagcgaaag cagcagcgac agcgacaaca gcggcggcgg tggaggcggc    420

ggtggaggcg gaggtggcgg cggcggcacc agcagtaaca acagcgagga agaagaggac    480

gacgacgacg aggaagagga ggtttctgag gtggagtctt tcattttgga tcaggatgat    540

ttggaaaatc caatgctgga aacagcttcc aagttgctct tatcaggtac tgctgatggt    600

gcagacctca ggacagtaga tccagaaaca caggctagac tggaagcttt actagaagct    660

gcaggaatag gaaaattgtc cacggctgat ggtaaagcct ttgcagatcc tgaagtactt    720

cggaggttga catcgtctgt tagttgtgcg ttggatgaag ctgctgctgc acttacccgt    780

atgagagctg aaagcacagc aaatgcaggg cagtcggaca accgcagttt ggcagaagcc    840

tgttcagaag gagatgtaaa tgctgtgcga aagttactca ttgaagggcg aagtgtaaat    900

gaacacacag aggaagggga gagcctcctt tgtttagctt gttctgctgg atactatgag    960

cttgcacagg ttttgttggc aatgcatgca aatgtggaag ataggggaat caaaggtgac   1020

attacacctt taatggctgc tgctaatgga ggacatgtca aaattgtgaa gttgctgcta   1080

gctcataaag cagatgttaa tgcacagtct tcaacaggca atacagcact tacatatgct   1140

tgtgctggag gctatgtaga tgttgtaaag gtgctcttgg aatccggtgc tagtattgag   1200

gaccataatg aaaatggtca tacccctctt atggaagctg gaagtgctgg acatgtggaa   1260

gtagccagat tgctgctaga aaatggggct ggcattaata cgcattctaa tgaatttaaa   1320

gagagtgccc ttaccttagc ttgttacaaa ggacacttag agatggtgcg atttcttttg   1380

gaagcaggcg cggatcaaga gcataaaaca gatgaaatgc acactgctct gatggaggct   1440

tgcatggatg gccatgttga agtagctagg ttacttcttg acagcggtgc ccaagtgaac   1500

atgcctgctg attcatttga gtcaccatta actttggctg catgtggtgg gcatgtggaa   1560

cttgcggctt tacttattga aagaggagct agcctggaag aggtcaatga tgaaggttat   1620

acaccattga tggaagcagc tcgagaagga catgaagaaa tggtggcatt acttcttggt   1680

caaggagcaa atatcaatgc acagacagaa gaaactcaag aaactgcctt gactctggct   1740

tgctgtggag gctttctgga agtggcagac tttctaatta aggcaggagc cgatatagaa   1800

ctagggtgtt ctaccccttt aatggaagct gctcaagagg gtcatttgga gttagttaaa   1860

tacttattag ctgcaggagc taacgttcat gcaacaacag caacagggga tacagcacta   1920

acatatgcct gtgaaaatgg tcatactgat gtagcagatg tcttacttca ggcaggcgca   1980

gatctggaac atgaatctga aggtggaaga actcctttaa tgaaagctgc aagagctggt   2040

catgtttgta ctgttcagtt cttaattagt aaaggagcga atgtgaatag aaccacagct   2100

aataatgacc atactgtact gtccctggct tgtgcagggg gtcatctggc agtggtggaa   2160

ctacttttgg ctcatggggc agatcctact caccgtttga aagatggctc aactatgttg   2220

atagaagcag caaaaggtgg ccatacaagt gttgtttgct atctcttgga ttatcctaat   2280

aacttgcttt cagcccctcc accagatgtc actcagttaa ctcccccatc ccacgattta   2340

aatagggctc ctcgtgtacc agttcaagca ctgcccatgg ttgttccacc tcaggagcct   2400

gacaaaccac ctgccaatgt tgccaccact cttcccatca ggaataaagc tgcttctaaa   2460

caaaagtcca gcagccattt gccagcaaac agccaggatg tacagggtta catcaccaat   2520

cagtctccag agagcattgt agaagaggct cagggaaagt taacagaact ggaacagagg   2580

ataaaagaag ccatagaaaa gaatgcacag ctgcagtcct tggaactggc tcatgctgac   2640

caacttacca aggagaagat cgaggagctc aacaaaacaa gggaggaaca aattcagaag   2700

aaacaaaaga ttttggagga actacagaaa gtagaacgag agttacaact gaaaactcag   2760

cagcagctaa aaaagcagta tctagaggtt aaagctcaaa gaattcaact tcagcaacag   2820

cagcaacagt cttgccaaca cctgggatta ctaactcctg ttggagttgg agagcagctt   2880

tctgagggag actatgcacg gttacagcaa gtggatcctg ttttacttaa agatgaaccc   2940

cagcagactg ctgctcagat gggttttgcg ccaatccagc ctctggcgat gcctcaagct   3000

ttgcctctgg cggcaggtcc cttgcctcca gggtccatcg caaatcttac agaactgcaa   3060

ggagtgatag ttggacagcc agtactgggc caagcacagt tggcagggct ggggcaagga   3120

attctgacag aaacacaaca agggttaatg gtagccagcc ctgctcagac cctcaatgac   3180

acgctggatg acatcatggc agcagtcagt ggaagagcat ctgcaatgtc aaacactcct   3240

acccacagta ttgctgcatc catttcccaa cctcagactc caactccaag tcctatcatc   3300

tctccttcag ccatgcttcc tatctaccct gccattgata ttgatgcaca gactgagagt   3360

aatcatgaca cggcgctaac acttgcctgt gctggtggcc acgaggaact ggtacaaaca   3420

ctgctagaga gaggagctag tatagagcac cgagacaaga aaggttttac tccactcatc   3480

ttggctgcca cagctggtca tgttggtgtt gtggaaatat tgctggacaa tggtgcagac   3540

attgaagccc agtctgaaag aaccaaggac acaccactct ccttggcttg ttctggggga   3600

agacaggagg tggtggagct attgttagct cgaggggcaa ataaagagca caggaatgtt   3660

tctgattaca cacctctaag tctggctgct tctggtggct atgtgaacat catcaaaata   3720

ttactaaatg caggagctga gattaactct agaactggta gcaaattggg catctctcct   3780

ctgatgttag cagctatgaa tgggcataca gctgctgtta agctcctgtt agacatgggc   3840

tctgacataa atgctcagat agaaaccaat cggaacactg cccttacttt agcctgcttc   3900

caaggaagaa ctgaagtggt tagtcttctg cttgatagaa aagcaaatgt tgaacacaga   3960

gctaagactg gtctcacacc actaatggaa gctgcctctg gtggatatgc ggaggtgggc   4020

cgagttcttt tggataaagg tgctgatgtt aatgcccctc cagttccctc ctcaagagat   4080

acagctttaa ccatagcagc agataaaggg cattacaaat tctgtgagct tcttattggc   4140

aggggagctc atattgatgt acgtaacaag aaggggaaca ctccattgtg gctagcagca   4200

aatggtggac acctcgatgt ggttcagtta ctggtgcaag caggtgcaga tgtggatgca   4260

gcagataacc gcaagataac tcctcttatg gcagcattta gaaagggtca tgtgaaggtg   4320

gtgcgctact tagtcaaaga agtcaatcag tttccatcag attctgaatg tatgagatac   4380

atagcaacca tcactgataa ggagatgctg aagaagtgtc atctttgtat ggagtcaata   4440

gtacaagcca aagatagaca ggctgctgaa gcaaacaaaa acgccagcat tttgttagag   4500

gagttagact tggaaaagtt aagggaagaa agtcggaggc tggctttggc tgcgaaaaga   4560

gaaaaaagaa aagagaagag aaggaagaaa aaggaagaac aaagaaggaa actagaagaa   4620

attgaagcca aaaataaaga gaactttgaa ctccaagctg ctcaagaaaa agaaaagctt   4680

aaagttgaag atgagcctga agtcttgaca gaacctccaa gtgccacaac cactactacc   4740

ataggtatat ctgcaacctg gacaactttg gcaggttctc atggtaaaag aaataatacc   4800

ataactacaa ccagttcaaa gaggaaaaac aggaaaaata aaattactcc agaaaacgtt   4860

caaattatat ttgatgatcc actaccaatt tcatacagtc agccagagaa ggtgaatgga   4920

gagtccaaga gcagcagtac cagcgagagt ggggacagtg ataacatgag gatttccagc   4980

tgcagcgatg aaagtagtaa cagcaacagc agtcgtaaga gtgacaatca ttcaccagct   5040

gtggtcacta ccactgtgag cagcaaaaag cagccatcag ttcttgttac atttccaaag   5100

gaagagagaa aatctgtttc tggcaaggct tcaataaaat tgtcagaaac tatcagtgaa   5160

gggaccagta attctctatc tacttgtaca aaatctggtc catctcccct ttcttctcca   5220

aatgggaagt taacagtagc aagtcctaag cgtgggcaaa agagggaaga aggatggaaa   5280

gaagttgtaa gaaggtcaaa gaaagtatct gttccatcaa ctgtgatatc cagagtgatt   5340

ggaagaggag gctgtaatat caatgctatt cgggagttta ctggtgcaca catagatatt   5400

gataaacaga aagacaagac tggagaccgg ataatcacta taaggggtgg cactgaatca   5460

acaagacaag caactcaatt gattaatgct ttgatcaagg atccagacaa agaaattgat   5520

gaacttattc caaagaatcg tttgaaaagc tcctcagcaa attccaaaat agggtcatca   5580

gcacctacca ccactgctgc taacacttcc ttaatgggaa ttaaaatgac aactgtagct   5640

ctgtcatcaa catctcaaac tgccacagca ctcactgtgc ctgcaatttc ttctgcatcc   5700

actcacaaaa ccattaagaa cccagtgaat aatgtgaggc ctggttttcc agtttctctt   5760

ccattagcat atcctcctcc acagtttgca catgctttgc ttgctgctca gactttccag   5820

cagatccgtc caccaaggtt gcccatgacc cactttggag gtacttttcc accagctcaa   5880

tccacttggg gtccgtttcc tgtcaggcct ttgagccctg ccagagctac taactcgcct   5940

aagcctcaca tggtgcctcg ccatagcaat cagaatagca gtggttctca ggtgaattca   6000

gcaggttctt taacttcaag cccaacaact acaaccagtt catcagcttc aacggtgcct   6060

ggtacatcta caaatggcag tccaagttca ccttctgtcc gaaggcagct ttttgtcaca   6120

gttgtgaaga catccaatgc caccacaaca acagtcacaa ccacggcaag caacaacaac   6180

actgcaccca caaatgccac atatcctatg cctactgcca aagaacacta tccagtatca   6240

tccccatctt ccccatcacc accagcccag ccaggagggg tttctagaaa cagccctttg   6300

gattgtggat cagcatctcc aaataaagtg gcatcttcct ccgaacagga agcaggtagt   6360

ccaccagtag tagaaacaac aaacactaga cctccaaaca gcagcagttc ttctgggagt   6420

tcatcagctc attctaatca gcaacaacct ccgggatctg tttctcagga accaagacca   6480

cctcttcagc agtctcaggt tcctcccccg gaagttagaa tgactgttcc tcctttagca   6540

acaagttctg ctccagtggc ggtgccttct actgccccag tgacttaccc tatgcctcag   6600

acaccaatgg gatgccccca gcctactcct aaaatggaaa cccctgctat tagaccaccc   6660

cctcatggca caactgcccc tcacaagaat tcagcttcag tgcaaaattc atctgttgca   6720

gtcctcagtg tcaatcacat taaaagacct cacagtgttc cctcttctgt ccagctacct   6780

tcgaccttaa gtacacaaag tgcttgtcag aattcagtac atccagcaaa taagcctatt   6840

gctcccaatt tcagtgcccc cttaccattt gggcccttta gcacattgtt tgaaaacagc   6900

cctacttctg ctcatgcctt ctggggagga tctgttgttt catctcagtc aacaccagaa   6960

tctatgctat caggaaaatc ctcatatttg ccaaattcag atcctttaca tcagtctgat   7020

acttccaaag ctccaggttt tagaccacca ttacagagac ctgctccaag tccctcaggt   7080

attgtcaata tggactcgcc atatggttct gtaacacctt cttcaacaca tttgggaaac   7140

tttgcttcaa acatttcagg aggtcagatg tacggacctg gggcacccct tggaggagca   7200

cccgcagctg ctaactttaa cagacaacat ttttccccgc ttagtttgtt gactccgtgt   7260

tcatcagcat caaatgattc ttctgcacag tcagtatcct cgggagttcg tgcaccatct   7320

cctgccccat catcagtacc gttagggtca gaaaagccca gcaatgtgtc tcaggacagg   7380

aaagttccag tccctattgg gactgaacgt tctgcacgta tcaggcaaac tggaacgtca   7440

gctccatctg ttattgggag caatttgtct acatcagtag gacatagtgg catctggtcc   7500

tttgaaggga ttggtggcaa tcaagacaaa gtagactggt gtaaccctgg gatgggaaat   7560

cctatgatcc acagaccgat gtctgaccca ggagtatttt cacaacatca agcaatggag   7620

cgagatagta caggaattgt aactccttct ggtacattcc atcagcatgt tcctgcaggc   7680

tacatggact ttcctaaagt tgggggtatg cctttttctg tgtatgggaa tgcaatgatt   7740

cctccagtag cacctatccc tgatggtgct ggaggaccca tatttaatgg ccctcatgct   7800

gcagaccctt cttggaactc actgataaag atggtttcca gctccacgga aaataatggc   7860

cctcaaacgg tgtggactgg accctgggca cctcacatga acagtgtgca tatgaaccag   7920

cttggctgat gaggatcagc ttgttagcct gcagattcct tttcatttgg aggaaatcac   7980

aagtggccga aaaaaaaaat tatgctccca aatcattcta ctgatgtgct tgactgaagt   8040

gtgtaggctt tttgcagaag atcttactaa ctgacctatt ttctgtgaac atttgtgact   8100

gcccattccc catcatcatc cgttttacct tagttagcat ttttcttatc atttttcttt   8160

ttttctttcc ctcttcccct ttggacataa ct                                 8192


<210>  290
<211>  2603
<212>  PRT
<213>  Homosapiens

<400>  290

Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly 
1               5                   10                  15      


Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala 
            20                  25                  30          


Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala 
        35                  40                  45              


Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys 
    50                  55                  60                  


Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys 
65                  70                  75                  80  


Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser 
            100                 105                 110         


Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu 
        115                 120                 125             


Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn 
    130                 135                 140                 


Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp 
145                 150                 155                 160 


Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu 
                165                 170                 175     


Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly 
            180                 185                 190         


Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val 
        195                 200                 205             


Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala 
    210                 215                 220                 


Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu 
225                 230                 235                 240 


Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu 
                245                 250                 255     


Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys 
            260                 265                 270         


Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala 
        275                 280                 285             


Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro 
    290                 295                 300                 


Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu 
305                 310                 315                 320 


Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr 
                325                 330                 335     


Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val 
            340                 345                 350         


Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His 
        355                 360                 365             


Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg 
    370                 375                 380                 


Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe 
385                 390                 395                 400 


Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met 
                405                 410                 415     


Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp 
            420                 425                 430         


Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu 
        435                 440                 445             


Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala 
    450                 455                 460                 


Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val 
465                 470                 475                 480 


Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val 
                485                 490                 495     


Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His 
            500                 505                 510         


Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala 
        515                 520                 525             


Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly 
    530                 535                 540                 


Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile 
545                 550                 555                 560 


Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His 
                565                 570                 575     


Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala 
            580                 585                 590         


Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly 
        595                 600                 605             


His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu 
    610                 615                 620                 


His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala 
625                 630                 635                 640 


Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val 
                645                 650                 655     


Asn Arg Thr Thr Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys 
            660                 665                 670         


Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala 
        675                 680                 685             


Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala 
    690                 695                 700                 


Ala Lys Gly Gly His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro 
705                 710                 715                 720 


Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro 
                725                 730                 735     


Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu 
            740                 745                 750         


Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val 
        755                 760                 765             


Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser 
    770                 775                 780                 


Ser Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Thr 
785                 790                 795                 800 


Asn Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Thr 
                805                 810                 815     


Glu Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu 
            820                 825                 830         


Gln Ser Leu Glu Leu Ala His Ala Asp Gln Leu Thr Lys Glu Lys Ile 
        835                 840                 845             


Glu Glu Leu Asn Lys Thr Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys 
    850                 855                 860                 


Ile Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Thr 
865                 870                 875                 880 


Gln Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile 
                885                 890                 895     


Gln Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu 
            900                 905                 910         


Thr Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg 
        915                 920                 925             


Leu Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Thr 
    930                 935                 940                 


Ala Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln 
945                 950                 955                 960 


Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn 
                965                 970                 975     


Leu Thr Glu Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln 
            980                 985                 990         


Ala Gln Leu Ala Gly Leu Gly Gln  Gly Ile Leu Thr Glu  Thr Gln Gln 
        995                 1000                 1005             


Gly Leu  Met Val Ala Ser Pro  Ala Gln Thr Leu Asn  Asp Thr Leu 
    1010                 1015                 1020             


Asp Asp  Ile Met Ala Ala Val  Ser Gly Arg Ala Ser  Ala Met Ser 
    1025                 1030                 1035             


Asn Thr  Pro Thr His Ser Ile  Ala Ala Ser Ile Ser  Gln Pro Gln 
    1040                 1045                 1050             


Thr Pro  Thr Pro Ser Pro Ile  Ile Ser Pro Ser Ala  Met Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Pro Ala Ile Asp Ile  Asp Ala Gln Thr Glu  Ser Asn His 
    1070                 1075                 1080             


Asp Thr  Ala Leu Thr Leu Ala  Cys Ala Gly Gly His  Glu Glu Leu 
    1085                 1090                 1095             


Val Gln  Thr Leu Leu Glu Arg  Gly Ala Ser Ile Glu  His Arg Asp 
    1100                 1105                 1110             


Lys Lys  Gly Phe Thr Pro Leu  Ile Leu Ala Ala Thr  Ala Gly His 
    1115                 1120                 1125             


Val Gly  Val Val Glu Ile Leu  Leu Asp Asn Gly Ala  Asp Ile Glu 
    1130                 1135                 1140             


Ala Gln  Ser Glu Arg Thr Lys  Asp Thr Pro Leu Ser  Leu Ala Cys 
    1145                 1150                 1155             


Ser Gly  Gly Arg Gln Glu Val  Val Glu Leu Leu Leu  Ala Arg Gly 
    1160                 1165                 1170             


Ala Asn  Lys Glu His Arg Asn  Val Ser Asp Tyr Thr  Pro Leu Ser 
    1175                 1180                 1185             


Leu Ala  Ala Ser Gly Gly Tyr  Val Asn Ile Ile Lys  Ile Leu Leu 
    1190                 1195                 1200             


Asn Ala  Gly Ala Glu Ile Asn  Ser Arg Thr Gly Ser  Lys Leu Gly 
    1205                 1210                 1215             


Ile Ser  Pro Leu Met Leu Ala  Ala Met Asn Gly His  Thr Ala Ala 
    1220                 1225                 1230             


Val Lys  Leu Leu Leu Asp Met  Gly Ser Asp Ile Asn  Ala Gln Ile 
    1235                 1240                 1245             


Glu Thr  Asn Arg Asn Thr Ala  Leu Thr Leu Ala Cys  Phe Gln Gly 
    1250                 1255                 1260             


Arg Thr  Glu Val Val Ser Leu  Leu Leu Asp Arg Lys  Ala Asn Val 
    1265                 1270                 1275             


Glu His  Arg Ala Lys Thr Gly  Leu Thr Pro Leu Met  Glu Ala Ala 
    1280                 1285                 1290             


Ser Gly  Gly Tyr Ala Glu Val  Gly Arg Val Leu Leu  Asp Lys Gly 
    1295                 1300                 1305             


Ala Asp  Val Asn Ala Pro Pro  Val Pro Ser Ser Arg  Asp Thr Ala 
    1310                 1315                 1320             


Leu Thr  Ile Ala Ala Asp Lys  Gly His Tyr Lys Phe  Cys Glu Leu 
    1325                 1330                 1335             


Leu Ile  Gly Arg Gly Ala His  Ile Asp Val Arg Asn  Lys Lys Gly 
    1340                 1345                 1350             


Asn Thr  Pro Leu Trp Leu Ala  Ala Asn Gly Gly His  Leu Asp Val 
    1355                 1360                 1365             


Val Gln  Leu Leu Val Gln Ala  Gly Ala Asp Val Asp  Ala Ala Asp 
    1370                 1375                 1380             


Asn Arg  Lys Ile Thr Pro Leu  Met Ala Ala Phe Arg  Lys Gly His 
    1385                 1390                 1395             


Val Lys  Val Val Arg Tyr Leu  Val Lys Glu Val Asn  Gln Phe Pro 
    1400                 1405                 1410             


Ser Asp  Ser Glu Cys Met Arg  Tyr Ile Ala Thr Ile  Thr Asp Lys 
    1415                 1420                 1425             


Glu Met  Leu Lys Lys Cys His  Leu Cys Met Glu Ser  Ile Val Gln 
    1430                 1435                 1440             


Ala Lys  Asp Arg Gln Ala Ala  Glu Ala Asn Lys Asn  Ala Ser Ile 
    1445                 1450                 1455             


Leu Leu  Glu Glu Leu Asp Leu  Glu Lys Leu Arg Glu  Glu Ser Arg 
    1460                 1465                 1470             


Arg Leu  Ala Leu Ala Ala Lys  Arg Glu Lys Arg Lys  Glu Lys Arg 
    1475                 1480                 1485             


Arg Lys  Lys Lys Glu Glu Gln  Arg Arg Lys Leu Glu  Glu Ile Glu 
    1490                 1495                 1500             


Ala Lys  Asn Lys Glu Asn Phe  Glu Leu Gln Ala Ala  Gln Glu Lys 
    1505                 1510                 1515             


Glu Lys  Leu Lys Val Glu Asp  Glu Pro Glu Val Leu  Thr Glu Pro 
    1520                 1525                 1530             


Pro Ser  Ala Thr Thr Thr Thr  Thr Ile Gly Ile Ser  Ala Thr Trp 
    1535                 1540                 1545             


Thr Thr  Leu Ala Gly Ser His  Gly Lys Arg Asn Asn  Thr Ile Thr 
    1550                 1555                 1560             


Thr Thr  Ser Ser Lys Arg Lys  Asn Arg Lys Asn Lys  Ile Thr Pro 
    1565                 1570                 1575             


Glu Asn  Val Gln Ile Ile Phe  Asp Asp Pro Leu Pro  Ile Ser Tyr 
    1580                 1585                 1590             


Ser Gln  Pro Glu Lys Val Asn  Gly Glu Ser Lys Ser  Ser Ser Thr 
    1595                 1600                 1605             


Ser Glu  Ser Gly Asp Ser Asp  Asn Met Arg Ile Ser  Ser Cys Ser 
    1610                 1615                 1620             


Asp Glu  Ser Ser Asn Ser Asn  Ser Ser Arg Lys Ser  Asp Asn His 
    1625                 1630                 1635             


Ser Pro  Ala Val Val Thr Thr  Thr Val Ser Ser Lys  Lys Gln Pro 
    1640                 1645                 1650             


Ser Val  Leu Val Thr Phe Pro  Lys Glu Glu Arg Lys  Ser Val Ser 
    1655                 1660                 1665             


Gly Lys  Ala Ser Ile Lys Leu  Ser Glu Thr Ile Ser  Glu Gly Thr 
    1670                 1675                 1680             


Ser Asn  Ser Leu Ser Thr Cys  Thr Lys Ser Gly Pro  Ser Pro Leu 
    1685                 1690                 1695             


Ser Ser  Pro Asn Gly Lys Leu  Thr Val Ala Ser Pro  Lys Arg Gly 
    1700                 1705                 1710             


Gln Lys  Arg Glu Glu Gly Trp  Lys Glu Val Val Arg  Arg Ser Lys 
    1715                 1720                 1725             


Lys Val  Ser Val Pro Ser Thr  Val Ile Ser Arg Val  Ile Gly Arg 
    1730                 1735                 1740             


Gly Gly  Cys Asn Ile Asn Ala  Ile Arg Glu Phe Thr  Gly Ala His 
    1745                 1750                 1755             


Ile Asp  Ile Asp Lys Gln Lys  Asp Lys Thr Gly Asp  Arg Ile Ile 
    1760                 1765                 1770             


Thr Ile  Arg Gly Gly Thr Glu  Ser Thr Arg Gln Ala  Thr Gln Leu 
    1775                 1780                 1785             


Ile Asn  Ala Leu Ile Lys Asp  Pro Asp Lys Glu Ile  Asp Glu Leu 
    1790                 1795                 1800             


Ile Pro  Lys Asn Arg Leu Lys  Ser Ser Ser Ala Asn  Ser Lys Ile 
    1805                 1810                 1815             


Gly Ser  Ser Ala Pro Thr Thr  Thr Ala Ala Asn Thr  Ser Leu Met 
    1820                 1825                 1830             


Gly Ile  Lys Met Thr Thr Val  Ala Leu Ser Ser Thr  Ser Gln Thr 
    1835                 1840                 1845             


Ala Thr  Ala Leu Thr Val Pro  Ala Ile Ser Ser Ala  Ser Thr His 
    1850                 1855                 1860             


Lys Thr  Ile Lys Asn Pro Val  Asn Asn Val Arg Pro  Gly Phe Pro 
    1865                 1870                 1875             


Val Ser  Leu Pro Leu Ala Tyr  Pro Pro Pro Gln Phe  Ala His Ala 
    1880                 1885                 1890             


Leu Leu  Ala Ala Gln Thr Phe  Gln Gln Ile Arg Pro  Pro Arg Leu 
    1895                 1900                 1905             


Pro Met  Thr His Phe Gly Gly  Thr Phe Pro Pro Ala  Gln Ser Thr 
    1910                 1915                 1920             


Trp Gly  Pro Phe Pro Val Arg  Pro Leu Ser Pro Ala  Arg Ala Thr 
    1925                 1930                 1935             


Asn Ser  Pro Lys Pro His Met  Val Pro Arg His Ser  Asn Gln Asn 
    1940                 1945                 1950             


Ser Ser  Gly Ser Gln Val Asn  Ser Ala Gly Ser Leu  Thr Ser Ser 
    1955                 1960                 1965             


Pro Thr  Thr Thr Thr Ser Ser  Ser Ala Ser Thr Val  Pro Gly Thr 
    1970                 1975                 1980             


Ser Thr  Asn Gly Ser Pro Ser  Ser Pro Ser Val Arg  Arg Gln Leu 
    1985                 1990                 1995             


Phe Val  Thr Val Val Lys Thr  Ser Asn Ala Thr Thr  Thr Thr Val 
    2000                 2005                 2010             


Thr Thr  Thr Ala Ser Asn Asn  Asn Thr Ala Pro Thr  Asn Ala Thr 
    2015                 2020                 2025             


Tyr Pro  Met Pro Thr Ala Lys  Glu His Tyr Pro Val  Ser Ser Pro 
    2030                 2035                 2040             


Ser Ser  Pro Ser Pro Pro Ala  Gln Pro Gly Gly Val  Ser Arg Asn 
    2045                 2050                 2055             


Ser Pro  Leu Asp Cys Gly Ser  Ala Ser Pro Asn Lys  Val Ala Ser 
    2060                 2065                 2070             


Ser Ser  Glu Gln Glu Ala Gly  Ser Pro Pro Val Val  Glu Thr Thr 
    2075                 2080                 2085             


Asn Thr  Arg Pro Pro Asn Ser  Ser Ser Ser Ser Gly  Ser Ser Ser 
    2090                 2095                 2100             


Ala His  Ser Asn Gln Gln Gln  Pro Pro Gly Ser Val  Ser Gln Glu 
    2105                 2110                 2115             


Pro Arg  Pro Pro Leu Gln Gln  Ser Gln Val Pro Pro  Pro Glu Val 
    2120                 2125                 2130             


Arg Met  Thr Val Pro Pro Leu  Ala Thr Ser Ser Ala  Pro Val Ala 
    2135                 2140                 2145             


Val Pro  Ser Thr Ala Pro Val  Thr Tyr Pro Met Pro  Gln Thr Pro 
    2150                 2155                 2160             


Met Gly  Cys Pro Gln Pro Thr  Pro Lys Met Glu Thr  Pro Ala Ile 
    2165                 2170                 2175             


Arg Pro  Pro Pro His Gly Thr  Thr Ala Pro His Lys  Asn Ser Ala 
    2180                 2185                 2190             


Ser Val  Gln Asn Ser Ser Val  Ala Val Leu Ser Val  Asn His Ile 
    2195                 2200                 2205             


Lys Arg  Pro His Ser Val Pro  Ser Ser Val Gln Leu  Pro Ser Thr 
    2210                 2215                 2220             


Leu Ser  Thr Gln Ser Ala Cys  Gln Asn Ser Val His  Pro Ala Asn 
    2225                 2230                 2235             


Lys Pro  Ile Ala Pro Asn Phe  Ser Ala Pro Leu Pro  Phe Gly Pro 
    2240                 2245                 2250             


Phe Ser  Thr Leu Phe Glu Asn  Ser Pro Thr Ser Ala  His Ala Phe 
    2255                 2260                 2265             


Trp Gly  Gly Ser Val Val Ser  Ser Gln Ser Thr Pro  Glu Ser Met 
    2270                 2275                 2280             


Leu Ser  Gly Lys Ser Ser Tyr  Leu Pro Asn Ser Asp  Pro Leu His 
    2285                 2290                 2295             


Gln Ser  Asp Thr Ser Lys Ala  Pro Gly Phe Arg Pro  Pro Leu Gln 
    2300                 2305                 2310             


Arg Pro  Ala Pro Ser Pro Ser  Gly Ile Val Asn Met  Asp Ser Pro 
    2315                 2320                 2325             


Tyr Gly  Ser Val Thr Pro Ser  Ser Thr His Leu Gly  Asn Phe Ala 
    2330                 2335                 2340             


Ser Asn  Ile Ser Gly Gly Gln  Met Tyr Gly Pro Gly  Ala Pro Leu 
    2345                 2350                 2355             


Gly Gly  Ala Pro Ala Ala Ala  Asn Phe Asn Arg Gln  His Phe Ser 
    2360                 2365                 2370             


Pro Leu  Ser Leu Leu Thr Pro  Cys Ser Ser Ala Ser  Asn Asp Ser 
    2375                 2380                 2385             


Ser Ala  Gln Ser Val Ser Ser  Gly Val Arg Ala Pro  Ser Pro Ala 
    2390                 2395                 2400             


Pro Ser  Ser Val Pro Leu Gly  Ser Glu Lys Pro Ser  Asn Val Ser 
    2405                 2410                 2415             


Gln Asp  Arg Lys Val Pro Val  Pro Ile Gly Thr Glu  Arg Ser Ala 
    2420                 2425                 2430             


Arg Ile  Arg Gln Thr Gly Thr  Ser Ala Pro Ser Val  Ile Gly Ser 
    2435                 2440                 2445             


Asn Leu  Ser Thr Ser Val Gly  His Ser Gly Ile Trp  Ser Phe Glu 
    2450                 2455                 2460             


Gly Ile  Gly Gly Asn Gln Asp  Lys Val Asp Trp Cys  Asn Pro Gly 
    2465                 2470                 2475             


Met Gly  Asn Pro Met Ile His  Arg Pro Met Ser Asp  Pro Gly Val 
    2480                 2485                 2490             


Phe Ser  Gln His Gln Ala Met  Glu Arg Asp Ser Thr  Gly Ile Val 
    2495                 2500                 2505             


Thr Pro  Ser Gly Thr Phe His  Gln His Val Pro Ala  Gly Tyr Met 
    2510                 2515                 2520             


Asp Phe  Pro Lys Val Gly Gly  Met Pro Phe Ser Val  Tyr Gly Asn 
    2525                 2530                 2535             


Ala Met  Ile Pro Pro Val Ala  Pro Ile Pro Asp Gly  Ala Gly Gly 
    2540                 2545                 2550             


Pro Ile  Phe Asn Gly Pro His  Ala Ala Asp Pro Ser  Trp Asn Ser 
    2555                 2560                 2565             


Leu Ile  Lys Met Val Ser Ser  Ser Thr Glu Asn Asn  Gly Pro Gln 
    2570                 2575                 2580             


Thr Val  Trp Thr Gly Pro Trp  Ala Pro His Met Asn  Ser Val His 
    2585                 2590                 2595             


Met Asn  Gln Leu Gly 
    2600             


<210>  291
<211>  2215
<212>  DNA
<213>  Homosapiens

<400>  291
agcttttctc ttctgtcaac cccacacgcc tttggcacaa tgaagtgggt aacctttatt     60

tcccttcttt ttctctttag ctcggcttat tccaggggtg tgtttcgtcg agatgcacac    120

aagagtgagg ttgctcatcg gtttaaagat ttgggagaag aaaatttcaa agccttggtg    180

ttgattgcct ttgctcagta tcttcagcag tgtccatttg aagatcatgt aaaattagtg    240

aatgaagtaa ctgaatttgc aaaaacatgt gttgctgatg agtcagctga aaattgtgac    300

aaatcacttc ataccctttt tggagacaaa ttatgcacag ttgcaactct tcgtgaaacc    360

tatggtgaaa tggctgactg ctgtgcaaaa caagaacctg agagaaatga atgcttcttg    420

caacacaaag atgacaaccc aaacctcccc cgattggtga gaccagaggt tgatgtgatg    480

tgcactgctt ttcatgacaa tgaagagaca tttttgaaaa aatacttata tgaaattgcc    540

agaagacatc cttactttta tgccccggaa ctccttttct ttgctaaaag gtataaagct    600

gcttttacag aatgttgcca agctgctgat aaagctgcct gcctgttgcc aaagctcgat    660

gaacttcggg atgaagggaa ggcttcgtct gccaaacaga gactcaagtg tgccagtctc    720

caaaaatttg gagaaagagc tttcaaagca tgggcagtag ctcgcctgag ccagagattt    780

cccaaagctg agtttgcaga agtttccaag ttagtgacag atcttaccaa agtccacacg    840

gaatgctgcc atggagatct gcttgaatgt gctgatgaca gggcggacct tgccaagtat    900

atctgtgaaa atcaagattc gatctccagt aaactgaagg aatgctgtga aaaacctctg    960

ttggaaaaat cccactgcat tgccgaagtg gaaaatgatg agatgcctgc tgacttgcct   1020

tcattagctg ctgattttgt tgaaagtaag gatgtttgca aaaactatgc tgaggcaaag   1080

gatgtcttcc tgggcatgtt tttgtatgaa tatgcaagaa ggcatcctga ttactctgtc   1140

gtgctgctgc tgagacttgc caagacatat gaaaccactc tagagaagtg ctgtgccgct   1200

gcagatcctc atgaatgcta tgccaaagtg ttcgatgaat ttaaacctct tgtggaagag   1260

cctcagaatt taatcaaaca aaattgtgag ctttttgagc agcttggaga gtacaaattc   1320

cagaatgcgc tattagttcg ttacaccaag aaagtacccc aagtgtcaac tccaactctt   1380

gtagaggtct caagaaacct aggaaaagtg ggcagcaaat gttgtaaaca tcctgaagca   1440

aaaagaatgc cctgtgcaga agactatcta tccgtggtcc tgaaccagtt atgtgtgttg   1500

catgagaaaa cgccagtaag tgacagagtc accaaatgct gcacagaatc cttggtgaac   1560

aggcgaccat gcttttcagc tctggaagtc gatgaaacat acgttcccaa agagtttaat   1620

gctgaaacat tcaccttcca tgcagatata tgcacacttt ctgagaagga gagacaaatc   1680

aagaaacaaa ctgcacttgt tgagctcgtg aaacacaagc ccaaggcaac aaaagagcaa   1740

ctgaaagctg ttatggatga tttcgcagct tttgtagaga agtgctgcaa ggctgacgat   1800

aaggagacct gctttgccga ggagggtaaa aaacttgttg ctgcaagtca agctgcctta   1860

ggcttataac atctacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa   1920

tgaagatcaa aagcttattc atctgttttc tttttcgttg gtgtaaagcc aacaccctgt   1980

ctaaaaaaca taaatttctt taatcatttt gcctcttttc tctgtgcttc aattaataaa   2040

aaatggaaag aatctaatag agtggtacag cactgttatt tttcaaagat gtgttgctat   2100

cctgaaaatt ctgtaggttc tgtggaagtt ccagtgttct ctcttattcc acttcggtag   2160

aggatttcta gtttctgtgg gctaattaaa taaatcacta atactcttct aagtt        2215


<210>  292
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  292

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  293
<211>  2032
<212>  DNA
<213>  Homosapiens

<400>  293
tccatattgt gcttccacca ctgccaataa caaaataact agcaaccatg aagtgggtgg     60

aatcaatttt tttaattttc ctactaaatt ttactgaatc cagaacactg catagaaatg    120

aatatggaat agcttccata ttggattctt accaatgtac tgcagagata agtttagctg    180

acctggctac catatttttt gcccagtttg ttcaagaagc cacttacaag gaagtaagca    240

aaatggtgaa agatgcattg actgcaattg agaaacccac tggagatgaa cagtcttcag    300

ggtgtttaga aaaccagcta cctgcctttc tggaagaact ttgccatgag aaagaaattt    360

tggagaagta cggacattca gactgctgca gccaaagtga agagggaaga cataactgtt    420

ttcttgcaca caaaaagccc actccagcat cgatcccact tttccaagtt ccagaacctg    480

tcacaagctg tgaagcatat gaagaagaca gggagacatt catgaacaaa ttcatttatg    540

agatagcaag aaggcatccc ttcctgtatg cacctacaat tcttctttgg gctgctcgct    600

atgacaaaat aattccatct tgctgcaaag ctgaaaatgc agttgaatgc ttccaaacaa    660

aggcagcaac agttacaaaa gaattaagag aaagcagctt gttaaatcaa catgcatgtg    720

cagtaatgaa aaattttggg acccgaactt tccaagccat aactgttact aaactgagtc    780

agaagtttac caaagttaat tttactgaaa tccagaaact agtcctggat gtggcccatg    840

tacatgagca ctgttgcaga ggagatgtgc tggattgtct gcaggatggg gaaaaaatca    900

tgtcctacat atgttctcaa caagacactc tgtcaaacaa aataacagaa tgctgcaaac    960

tgaccacgct ggaacgtggt caatgtataa ttcatgcaga aaatgatgaa aaacctgaag   1020

gtctatctcc aaatctaaac aggtttttag gagatagaga ttttaaccaa ttttcttcag   1080

gggaaaaaaa tatcttcttg gcaagttttg ttcatgaata ttcaagaaga catcctcagc   1140

ttgctgtctc agtaattcta agagttgcta aaggatacca ggagttattg gagaagtgtt   1200

tccagactga aaaccctctt gaatgccaag ataaaggaga agaagaatta cagaaataca   1260

tccaggagag ccaagcattg gcaaagcgaa gctgcggcct cttccagaaa ctaggagaat   1320

attacttaca aaatgcgttt ctcgttgctt acacaaagaa agccccccag ctgacctcgt   1380

cggagctgat ggccatcacc agaaaaatgg cagccacagc agccacttgt tgccaactca   1440

gtgaggacaa actattggcc tgtggcgagg gagcggctga cattattatc ggacacttat   1500

gtatcagaca tgaaatgact ccagtaaacc ctggtgttgg ccagtgctgc acttcttcat   1560

atgccaacag gaggccatgc ttcagcagct tggtggtgga tgaaacatat gtccctcctg   1620

cattctctga tgacaagttc attttccata aggatctgtg ccaagctcag ggtgtagcgc   1680

tgcaaacgat gaagcaagag tttctcatta accttgtgaa gcaaaagcca caaataacag   1740

aggaacaact tgaggctgtc attgcagatt tctcaggcct gttggagaaa tgctgccaag   1800

gccaggaaca ggaagtctgc tttgctgaag agggacaaaa actgatttca aaaactcgtg   1860

ctgctttggg agtttaaatt acttcagggg aagagaagac aaaacgagtc tttcattcgg   1920

tgtgaacttt tctctttaat tttaactgat ttaacacttt ttgtgaatta atgaaatgat   1980

aaagactttt atgtgagatt tccttatcac agaaataaaa tatctccaaa tg           2032


<210>  294
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  294

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  295
<211>  1997
<212>  DNA
<213>  Homosapiens

<400>  295
actttctttt gtaaatgtgg tttctacaaa gatgaaacta ctaaaactta caggttttat     60

ttttttcttg ttttttttga ctgaatccct aaccctgccc acacaacctc gggatataga    120

gaacttcaat agtactcaaa aatttataga agataatatt gaatacatca ccatcattgc    180

atttgctcag tatgttcagg aagcaacctt tgaagaaatg gaaaagctgg tgaaagacat    240

ggtagaatac aaagacagat gtatggctga caagacgctc ccagagtgtt caaaattacc    300

taataatgtt ttacaggaaa aaatatgtgc tatggagggg ctgccacaaa agcataattt    360

ctcacactgc tgcagtaagg ttgatgctca aagaagactc tgtttcttct ataacaagaa    420

atctgatgtg ggatttctgc ctcctttccc taccctggat cccgaagaga aatgccaggc    480

ttatgaaagt aacagagaat cccttttaaa tcacttttta tatgaagttg ccagaaggaa    540

cccatttgtc ttcgccccta cacttctaac tgttgctgtt cattttgagg aggtggccaa    600

atcatgttgt gaagaacaaa acaaagtcaa ctgccttcaa acaagggcaa tacctgtcac    660

acaatattta aaagcatttt cttcttatca aaaacatgtc tgtggggcac ttttgaaatt    720

tggaaccaaa gttgtacact ttatatatat tgcgatactc agtcaaaaat tccccaagat    780

tgaatttaag gagcttattt ctcttgtaga agatgtttct tccaactatg atggatgctg    840

tgaaggggat gttgtgcagt gcatccgtga cacgagcaag gttatgaacc atatttgttc    900

aaaacaagat tctatctcca gcaaaatcaa agagtgctgt gaaaagaaaa taccagagcg    960

cggccagtgc ataattaact caaacaaaga tgatagacca aaggatttat ctctaagaga   1020

aggaaaattt actgacagtg aaaatgtgtg tcaagaacga gatgctgacc cagacacctt   1080

ctttgcgaag tttacttttg aatactcaag gagacatcca gacctgtcta taccagagct   1140

tttaagaatt gttcaaatat acaaagatct cctgagaaat tgctgcaaca cagaaaaccc   1200

tccaggttgt taccgttacg cggaagacaa attcaatgag acaactgaga aaagcctcaa   1260

gatggtacaa caagaatgta aacatttcca gaatttgggg aaggatggtt tgaaatacca   1320

ttacctcatc aggctcacga agatagctcc ccaactctcc actgaagaac tggtgtctct   1380

tggcgagaaa atggtgacag ctttcactac ttgctgtacg ctaagtgaag agtttgcctg   1440

tgttgataat ttggcagatt tagtttttgg agagttatgt ggagtaaatg aaaatcgaac   1500

tatcaaccct gctgtggacc actgctgtaa aacaaacttt gccttcagaa ggccctgctt   1560

tgagagtttg aaagctgata aaacatatgt gcctccacct ttctctcaag atttatttac   1620

ctttcacgca gacatgtgtc aatctcagaa tgaggagctt cagaggaaga cagacaggtt   1680

tcttgtcaac ttagtgaagc tgaagcatga actcacagat gaagagctgc agtctttgtt   1740

tacaaatttc gcaaatgtag tggataagtg ctgcaaagca gagagtcctg aagtctgctt   1800

taatgaagag agtccaaaaa ttggcaactg aagccagctg ctggagatat gtaaagaaaa   1860

aagcaccaaa gggaaggctt cctatctgtg tggtgatgaa tcgcatttcc tgagaacaaa   1920

ataaaaggat ttttctgtaa ctgtcacctg aaataataca ttgcagcaag caataaacac   1980

aacattttgt aaagtta                                                  1997


<210>  296
<211>  599
<212>  PRT
<213>  Homosapiens

<400>  296

Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210>  297
<211>  4268
<212>  DNA
<213>  Homosapiens

<400>  297
agcccggcag agacagggca ctggtttccc tctaccagag ttcctgaccc agccgagaac     60

aaaccgcgaa gcaagttcag ccgaacaacg atggtgaaaa gggtcctcct gctcacagtg    120

tgaataacag gatatcctca gaccatctca aaaaggagga aaagatgact atgatggctc    180

accagtaccc ctcttggatc ttcattaatg agaagacatt cataaccagg gaacaactta    240

attctttatt gaagacctat aacatttttt atgagaacca gaaaaatctg catattttat    300

atggagagac tgaagatggc aaactaattg ttgaaggaat gctggacatt ttctggggag    360

taaaacgacc tatacagcta aaaatacaag atgagaagcc attctcttct tttactagta    420

tgaagtcatc agacgtcttc tccagcaaag gaatgacacg ctggggggaa tttgacgatc    480

tctatcgtat tagtgagctg gacaggaccc agattcctat gtctgaaaaa aggaattccc    540

aggaagacta tttatcttat cacagcaaca ccctgaagcc acatgcaaag gatgaaccag    600

actccccagt gctctataga accatgagtg aagcagctct ggtgagaaaa aggatgaagc    660

ctctgatgat ggacagaaaa gaaagacaga aaaatagagc ctctattaat ggacacttct    720

ataaccatga aacatcaatt ttcattccag cctttgaatc agaaactaag gtcagagtaa    780

acagtaacat gagaactgaa gaagtaataa agcaacttct ccaaaaattt aagattgaaa    840

atagtcccca ggattttgct cttcacatta tttttgcaac aggagaacaa agacgactaa    900

agaagacaga cattccgcta ctgcagaggc tcctacaggg accttctgaa aagaatgctc    960

gcattttcct catggataaa gatgcagaag aaattagcag tgatgtggct cagtacatta   1020

actttcactt ttctctcttg gaatccattc ttcaaagatt aaatgaagaa gagaaaagag   1080

agattcaaag aatagtaaca aaattcaata aagaaaaggc gattatactg aaatgtcttc   1140

aaaataaact agtaataaaa acagagacaa cagtttagca gtacaagctt ctattgctaa   1200

aacatttcaa aaaactcaga gatattactc tttgatgaat gcataagttc tgtacttgca   1260

tttatacgaa catatatgag acttgaatcg tagaaaattg aatgtcaaaa aaagctcatt   1320

tctttttgaa gtgatgaggt taattagggt tcacagttgg acaaaatgag tttgagttta   1380

gtttcagtaa ctgaaataag cttgaatact gcatatgcca aatagctttt atagtaaacc   1440

atgtaatgaa ctcaaattta aatggtgtct tcagataagc agtttaaact tcatttagct   1500

tggactctca agagaactga aacataatca atggattcag aaatgactca gaaaaaagaa   1560

gctgccagtt cttggaatga aaaagaaata cagtcttaca ccatcaagga atctacctga   1620

tagtgacagt agcttcttga aaactctggc attttcataa aatctaggac tatcttaaat   1680

ggcctgttga cttctgacta tctgtaacat cagagctgtc tggcctttgg aaaggaaaaa   1740

ttatggactc tgttaagaaa tcctaattga aattttctga acctcccccc agccctttta   1800

ttctctctct tctgctgatg aaagaccttt catcagttca aagcttttct taagctcttt   1860

tttaagttaa ttgaactttt tctttattta tttttcaaaa aaatgtttat atcacataga   1920

catattacat cggctaaagc aagacttggc ccacaaatac ctatttgttg ctgaatgaat   1980

acaatggata aagcaaggct gttgtagctg aagttacata gggaatccca aactctgccc   2040

tcttagcatc ttattctaca tgacaactct caaggtactc acagatctgt ttaacccact   2100

tgaaaaaaaa acactaaaaa tgaagaaatg ctataagtat aaactatgat tttatttata   2160

aattctgtat taaaatggaa ttatatgcaa cattctttca ttctgtaaac taattccatt   2220

tgcattcctc ataagcattg tagtaaattg atcatattac atgtactaag gaatgagatt   2280

atatgcagta aacccaactg gaagattaac aatattaaaa tatgaaacat ttttaagaca   2340

aaggcattac ttctcagtat taccaaacct aaactggttg aaggtgaaag tgtgctatgg   2400

ccttttcaag cctaagaagt ctctcttact gagtaaacca gaggcttgca tcgctattct   2460

ttcacctgtc aatattaata agaaaatagt ctcatctcac ttaaatgagg caaatgtaat   2520

agttaaaatt caacatactt ataaaaaact agtgtcatgt acctgccatg aacatgacaa   2580

aaggttagtc ttcaatagac tgaaatgtat aagagaagaa ccaagtctta catagaaaaa   2640

aaaggtagat atgaaaagaa aaatcacaga agagagaatg caaatggcca ctaagtatat   2700

gaaaaaagtc gtatcttaac agtgaacaac tgtgttagtc tgtatcaatc agaagacaga   2760

aacaaggtag taatttaaac agggaaagtt taatataaat aataattaag ctatgatagg   2820

agaataataa taaagatgaa aagagaaggt accctaaggc tgagggaaag aatcctaaca   2880

aggaaaggca ggaatgaggg tttcagaatt cactggagaa ggtgtggttg cagcccactg   2940

gagagaagtt tgctggcttg cccaggccag agcaggacca cagatactgg acaagctggt   3000

acagccaacc ccctaggtgt ggaccagctg aggcaggtgg gcagatatgc agagggactt   3060

ggggctttgc caaagggtaa gcacaaagaa ggagtcacgg gttctgttcg aggcactgtt   3120

gggattagga gtcggaggga cctactttgc aggaacctag cataactttg tgtgacgaga   3180

ctgcacaaga caaagctcag gcaagtggct cagtagttgg ccagcccagc agggtcctct   3240

gtatgagtgt gcacccagct gaagagaaga aatggagagc agcaattgga gcttcaggac   3300

cggcttgcac tgtggctcca ggttatacca ccactgccca aagcaaaagc tagagaagca   3360

agtggagaaa tgctggagaa agctgcaccc tacaggcaac cagcactgca gaaaccactc   3420

caggcaaagt agtgaaggaa aaaagcctgc tctccagtag cctggcctgt cagcctggag   3480

gaatcaggaa agaccccttc ctcttgcagt gtgtctccag cgccctctac tgacaaagta   3540

tgccatcatg caagctgcaa aggaaacatt tcaagagtct atatctattt tcacggagcg   3600

ggcaaccaac agtgaatgtg gagctgagag acagtaaaat aataactgac atgccaccga   3660

agtacaaagt aaaataaata aataaataca cattttggcc tattagcaaa gattaagaaa   3720

tgataacatt aaatactcaa taaatcacca tgagatgggg actcaaactt ctggtaaaaa   3780

tacaaataga tataattttt cttgaaggca atttagtagt ctgtttatcc tataattcta   3840

cttgtaagat cctatcatat gaaaataacc agagatacaa agacattctg caaagatatg   3900

ttttatattg ttatttattg tgacaaaagg aaataaaaag cctaaatgtt cagaaaatta   3960

ttttaaaaga tgaaagaggg aaataggcca tggacggtgg ctcacgcctg taatcccagc   4020

actttaggag gccaaggtag gtggatcact tgaggttggg atttcgagac cagcctggcc   4080

aacatggtga aaccctgcct ctactaaaaa tacaaaaaat gagccgggtg caatggcagg   4140

cgcctataat gccagctact cgggaggctg aggcaggaga atcgcttgaa cccgggaggc   4200

ggaggttgca tgagccgaga tggcgccact gctctccagc ctggacgaca gagcaagact   4260

ccgtctct                                                            4268


<210>  298
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  298

Met Thr Met Met Ala His Gln Tyr Pro Ser Trp Ile Phe Ile Asn Glu 
1               5                   10                  15      


Lys Thr Phe Ile Thr Arg Glu Gln Leu Asn Ser Leu Leu Lys Thr Tyr 
            20                  25                  30          


Asn Ile Phe Tyr Glu Asn Gln Lys Asn Leu His Ile Leu Tyr Gly Glu 
        35                  40                  45              


Thr Glu Asp Gly Lys Leu Ile Val Glu Gly Met Leu Asp Ile Phe Trp 
    50                  55                  60                  


Gly Val Lys Arg Pro Ile Gln Leu Lys Ile Gln Asp Glu Lys Pro Phe 
65                  70                  75                  80  


Ser Ser Phe Thr Ser Met Lys Ser Ser Asp Val Phe Ser Ser Lys Gly 
                85                  90                  95      


Met Thr Arg Trp Gly Glu Phe Asp Asp Leu Tyr Arg Ile Ser Glu Leu 
            100                 105                 110         


Asp Arg Thr Gln Ile Pro Met Ser Glu Lys Arg Asn Ser Gln Glu Asp 
        115                 120                 125             


Tyr Leu Ser Tyr His Ser Asn Thr Leu Lys Pro His Ala Lys Asp Glu 
    130                 135                 140                 


Pro Asp Ser Pro Val Leu Tyr Arg Thr Met Ser Glu Ala Ala Leu Val 
145                 150                 155                 160 


Arg Lys Arg Met Lys Pro Leu Met Met Asp Arg Lys Glu Arg Gln Lys 
                165                 170                 175     


Asn Arg Ala Ser Ile Asn Gly His Phe Tyr Asn His Glu Thr Ser Ile 
            180                 185                 190         


Phe Ile Pro Ala Phe Glu Ser Glu Thr Lys Val Arg Val Asn Ser Asn 
        195                 200                 205             


Met Arg Thr Glu Glu Val Ile Lys Gln Leu Leu Gln Lys Phe Lys Ile 
    210                 215                 220                 


Glu Asn Ser Pro Gln Asp Phe Ala Leu His Ile Ile Phe Ala Thr Gly 
225                 230                 235                 240 


Glu Gln Arg Arg Leu Lys Lys Thr Asp Ile Pro Leu Leu Gln Arg Leu 
                245                 250                 255     


Leu Gln Gly Pro Ser Glu Lys Asn Ala Arg Ile Phe Leu Met Asp Lys 
            260                 265                 270         


Asp Ala Glu Glu Ile Ser Ser Asp Val Ala Gln Tyr Ile Asn Phe His 
        275                 280                 285             


Phe Ser Leu Leu Glu Ser Ile Leu Gln Arg Leu Asn Glu Glu Glu Lys 
    290                 295                 300                 


Arg Glu Ile Gln Arg Ile Val Thr Lys Phe Asn Lys Glu Lys Ala Ile 
305                 310                 315                 320 


Ile Leu Lys Cys Leu Gln Asn Lys Leu Val Ile Lys Thr Glu Thr Thr 
                325                 330                 335     


Val 
    


<210>  299
<211>  4323
<212>  DNA
<213>  Homosapiens

<400>  299
acagggagtg gctcaggttt cttgacactt ccctgctgtg gcgaaaagga gaaataatta     60

acagctcctg gggctctagg atcgctgatc gcgtcggggg cactgcaagc gcccagctga    120

gccatgctct gggaggagac aggcgccgcc cctgcgcccg cgcgggcctc ggacctcccc    180

tacaggatat cctcagacca tctcaaaaag gaggaaaaga tgactatgat ggctcaccag    240

tacccctctt ggatcttcat taatgagaag acattcataa ccagggaaca acttaattct    300

ttattgaaga cctataacat tttttatgag aaccagaaaa atctgcatat tttatatgga    360

gagactgaag atggcaaact aattgttgaa ggaatgctgg acattttctg gggagtaaaa    420

cgacctatac agctaaaaat acaagatgag aagccattct cttcttttac tagtatgaag    480

tcatcagacg tcttctccag caaaggaatg acacgctggg gggaatttga cgatctctat    540

cgtattagtg agctggacag gacccagatt cctatgtctg aaaaaaggaa ttcccaggaa    600

gactatttat cttatcacag caacaccctg aagccacatg caaaggatga accagactcc    660

ccagtgctct atagaaccat gagtgaagca gctctggtga gaaaaaggat gaagcctctg    720

atgatggaca gaaaagaaag acagaaaaat agagcctcta ttaatggaca cttctataac    780

catgaaacat caattttcat tccagccttt gaatcagaaa ctaaggtcag agtaaacagt    840

aacatgagaa ctgaagaagt aataaagcaa cttctccaaa aatttaagat tgaaaatagt    900

ccccaggatt ttgctcttca cattattttt gcaacaggag aacaaagacg actaaagaag    960

acagacattc cgctactgca gaggctccta cagggacctt ctgaaaagaa tgctcgcatt   1020

ttcctcatgg ataaagatgc agaagaaatt agcagtgatg tggctcagta cattaacttt   1080

cacttttctc tcttggaatc cattcttcaa agattaaatg aagaagagaa aagagagatt   1140

caaagaatag taacaaaatt caataaagaa aaggcgatta tactgaaatg tcttcaaaat   1200

aaactagtaa taaaaacaga gacaacagtt tagcagtaca agcttctatt gctaaaacat   1260

ttcaaaaaac tcagagatat tactctttga tgaatgcata agttctgtac ttgcatttat   1320

acgaacatat atgagacttg aatcgtagaa aattgaatgt caaaaaaagc tcatttcttt   1380

ttgaagtgat gaggttaatt agggttcaca gttggacaaa atgagtttga gtttagtttc   1440

agtaactgaa ataagcttga atactgcata tgccaaatag cttttatagt aaaccatgta   1500

atgaactcaa atttaaatgg tgtcttcaga taagcagttt aaacttcatt tagcttggac   1560

tctcaagaga actgaaacat aatcaatgga ttcagaaatg actcagaaaa aagaagctgc   1620

cagttcttgg aatgaaaaag aaatacagtc ttacaccatc aaggaatcta cctgatagtg   1680

acagtagctt cttgaaaact ctggcatttt cataaaatct aggactatct taaatggcct   1740

gttgacttct gactatctgt aacatcagag ctgtctggcc tttggaaagg aaaaattatg   1800

gactctgtta agaaatccta attgaaattt tctgaacctc cccccagccc ttttattctc   1860

tctcttctgc tgatgaaaga cctttcatca gttcaaagct tttcttaagc tcttttttaa   1920

gttaattgaa ctttttcttt atttattttt caaaaaaatg tttatatcac atagacatat   1980

tacatcggct aaagcaagac ttggcccaca aatacctatt tgttgctgaa tgaatacaat   2040

ggataaagca aggctgttgt agctgaagtt acatagggaa tcccaaactc tgccctctta   2100

gcatcttatt ctacatgaca actctcaagg tactcacaga tctgtttaac ccacttgaaa   2160

aaaaaacact aaaaatgaag aaatgctata agtataaact atgattttat ttataaattc   2220

tgtattaaaa tggaattata tgcaacattc tttcattctg taaactaatt ccatttgcat   2280

tcctcataag cattgtagta aattgatcat attacatgta ctaaggaatg agattatatg   2340

cagtaaaccc aactggaaga ttaacaatat taaaatatga aacattttta agacaaaggc   2400

attacttctc agtattacca aacctaaact ggttgaaggt gaaagtgtgc tatggccttt   2460

tcaagcctaa gaagtctctc ttactgagta aaccagaggc ttgcatcgct attctttcac   2520

ctgtcaatat taataagaaa atagtctcat ctcacttaaa tgaggcaaat gtaatagtta   2580

aaattcaaca tacttataaa aaactagtgt catgtacctg ccatgaacat gacaaaaggt   2640

tagtcttcaa tagactgaaa tgtataagag aagaaccaag tcttacatag aaaaaaaagg   2700

tagatatgaa aagaaaaatc acagaagaga gaatgcaaat ggccactaag tatatgaaaa   2760

aagtcgtatc ttaacagtga acaactgtgt tagtctgtat caatcagaag acagaaacaa   2820

ggtagtaatt taaacaggga aagtttaata taaataataa ttaagctatg ataggagaat   2880

aataataaag atgaaaagag aaggtaccct aaggctgagg gaaagaatcc taacaaggaa   2940

aggcaggaat gagggtttca gaattcactg gagaaggtgt ggttgcagcc cactggagag   3000

aagtttgctg gcttgcccag gccagagcag gaccacagat actggacaag ctggtacagc   3060

caacccccta ggtgtggacc agctgaggca ggtgggcaga tatgcagagg gacttggggc   3120

tttgccaaag ggtaagcaca aagaaggagt cacgggttct gttcgaggca ctgttgggat   3180

taggagtcgg agggacctac tttgcaggaa cctagcataa ctttgtgtga cgagactgca   3240

caagacaaag ctcaggcaag tggctcagta gttggccagc ccagcagggt cctctgtatg   3300

agtgtgcacc cagctgaaga gaagaaatgg agagcagcaa ttggagcttc aggaccggct   3360

tgcactgtgg ctccaggtta taccaccact gcccaaagca aaagctagag aagcaagtgg   3420

agaaatgctg gagaaagctg caccctacag gcaaccagca ctgcagaaac cactccaggc   3480

aaagtagtga aggaaaaaag cctgctctcc agtagcctgg cctgtcagcc tggaggaatc   3540

aggaaagacc ccttcctctt gcagtgtgtc tccagcgccc tctactgaca aagtatgcca   3600

tcatgcaagc tgcaaaggaa acatttcaag agtctatatc tattttcacg gagcgggcaa   3660

ccaacagtga atgtggagct gagagacagt aaaataataa ctgacatgcc accgaagtac   3720

aaagtaaaat aaataaataa atacacattt tggcctatta gcaaagatta agaaatgata   3780

acattaaata ctcaataaat caccatgaga tggggactca aacttctggt aaaaatacaa   3840

atagatataa tttttcttga aggcaattta gtagtctgtt tatcctataa ttctacttgt   3900

aagatcctat catatgaaaa taaccagaga tacaaagaca ttctgcaaag atatgtttta   3960

tattgttatt tattgtgaca aaaggaaata aaaagcctaa atgttcagaa aattatttta   4020

aaagatgaaa gagggaaata ggccatggac ggtggctcac gcctgtaatc ccagcacttt   4080

aggaggccaa ggtaggtgga tcacttgagg ttgggatttc gagaccagcc tggccaacat   4140

ggtgaaaccc tgcctctact aaaaatacaa aaaatgagcc gggtgcaatg gcaggcgcct   4200

ataatgccag ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcggagg   4260

ttgcatgagc cgagatggcg ccactgctct ccagcctgga cgacagagca agactccgtc   4320

tct                                                                 4323


<210>  300
<211>  369
<212>  PRT
<213>  Homosapiens

<400>  300

Met Leu Trp Glu Glu Thr Gly Ala Ala Pro Ala Pro Ala Arg Ala Ser 
1               5                   10                  15      


Asp Leu Pro Tyr Arg Ile Ser Ser Asp His Leu Lys Lys Glu Glu Lys 
            20                  25                  30          


Met Thr Met Met Ala His Gln Tyr Pro Ser Trp Ile Phe Ile Asn Glu 
        35                  40                  45              


Lys Thr Phe Ile Thr Arg Glu Gln Leu Asn Ser Leu Leu Lys Thr Tyr 
    50                  55                  60                  


Asn Ile Phe Tyr Glu Asn Gln Lys Asn Leu His Ile Leu Tyr Gly Glu 
65                  70                  75                  80  


Thr Glu Asp Gly Lys Leu Ile Val Glu Gly Met Leu Asp Ile Phe Trp 
                85                  90                  95      


Gly Val Lys Arg Pro Ile Gln Leu Lys Ile Gln Asp Glu Lys Pro Phe 
            100                 105                 110         


Ser Ser Phe Thr Ser Met Lys Ser Ser Asp Val Phe Ser Ser Lys Gly 
        115                 120                 125             


Met Thr Arg Trp Gly Glu Phe Asp Asp Leu Tyr Arg Ile Ser Glu Leu 
    130                 135                 140                 


Asp Arg Thr Gln Ile Pro Met Ser Glu Lys Arg Asn Ser Gln Glu Asp 
145                 150                 155                 160 


Tyr Leu Ser Tyr His Ser Asn Thr Leu Lys Pro His Ala Lys Asp Glu 
                165                 170                 175     


Pro Asp Ser Pro Val Leu Tyr Arg Thr Met Ser Glu Ala Ala Leu Val 
            180                 185                 190         


Arg Lys Arg Met Lys Pro Leu Met Met Asp Arg Lys Glu Arg Gln Lys 
        195                 200                 205             


Asn Arg Ala Ser Ile Asn Gly His Phe Tyr Asn His Glu Thr Ser Ile 
    210                 215                 220                 


Phe Ile Pro Ala Phe Glu Ser Glu Thr Lys Val Arg Val Asn Ser Asn 
225                 230                 235                 240 


Met Arg Thr Glu Glu Val Ile Lys Gln Leu Leu Gln Lys Phe Lys Ile 
                245                 250                 255     


Glu Asn Ser Pro Gln Asp Phe Ala Leu His Ile Ile Phe Ala Thr Gly 
            260                 265                 270         


Glu Gln Arg Arg Leu Lys Lys Thr Asp Ile Pro Leu Leu Gln Arg Leu 
        275                 280                 285             


Leu Gln Gly Pro Ser Glu Lys Asn Ala Arg Ile Phe Leu Met Asp Lys 
    290                 295                 300                 


Asp Ala Glu Glu Ile Ser Ser Asp Val Ala Gln Tyr Ile Asn Phe His 
305                 310                 315                 320 


Phe Ser Leu Leu Glu Ser Ile Leu Gln Arg Leu Asn Glu Glu Glu Lys 
                325                 330                 335     


Arg Glu Ile Gln Arg Ile Val Thr Lys Phe Asn Lys Glu Lys Ala Ile 
            340                 345                 350         


Ile Leu Lys Cys Leu Gln Asn Lys Leu Val Ile Lys Thr Glu Thr Thr 
        355                 360                 365             


Val 
    


<210>  301
<211>  3260
<212>  DNA
<213>  Homosapiens

<400>  301
gtctcttagc aactaagccc ccggctcctc cagaagcccc tcttcgcaca tgcgcaaact     60

gcggacgggg aactgggctc cctagccctg gcgtttttgg tgttgctgtc ccagccagaa    120

tcgcgtctgg ccggtgggaa gccgggaact ccagccccct gtaggagagg agaaaggagc    180

gagatcatga tacatggtga tggcttgcag agtcgtaaac aaaagaagac acatgggact    240

tcaacaactt tcatcattcg cggaaacagg aagaactttc ctaggcccac taaaatcatc    300

caaatttatt atagatgaag aatgtcatga aagtgtatta atcagttcaa cagtaaggct    360

tcttgaaagt ttggatttaa ccagtgcagt gggacaactt ctcaatgaag cagttcaagc    420

acaaaacaac acatatagaa ctggaatcag tactcttttg tttcttgttg gtgcttggag    480

cagtgcagtt gaagaatgtc ttcatcttgg tgtccccatt tccataatag tatcagtaat    540

gtcagaaggc ttaaactttt gtagtgaaga ggtagtttct cttcatgtac ctgttcacaa    600

tatatttgac tgtatggaca gcacaaaaac attttctcaa cttgaaacat ttagtgtaag    660

tttgtgtcct tttctacagg tcccttcaga tactgatttg atagaggaat tgcatggtct    720

caaagatgtt gcctctcaaa cactgaccat ttccaacctt tctgggagac ctcttaaatc    780

atatgaatta tttaaacctc agacaaaggt tgaagcagat aacaacacat cacgaactct    840

gaaaaacagc ctgcttgcag atacctgctg cagacagtca atactaatcc acagtaggca    900

ttttaatagg acagataata ctgaaggggt aagcaaacca gatggatttc aagaacatgt    960

tacagctact cacaaaactt acagatgtaa tgatttggta gagttggcag taggcttgag   1020

tcatggagat cacagcagca tgaagttagt agaagaagca gtacagctgc aatatcagaa   1080

tgcttgtgtg caacaaggca actgtacaaa accatttatg tttgacattt caagaatttt   1140

cacttgctgt ctaccaggct tacctgaaac ttcttcttgt gtttgtccag gatatatcac   1200

tgttgtgtca gtatctaata atcctgtgat caaggaattg cagaatcagc ctgtgcgaat   1260

agttctcatt gagggtgacc tcacagagaa ttaccgccac ctgggattta ataagtctgc   1320

aaatattaaa acagtattag atagcatgcg gcttcaagaa gacagctcag aagaactgtg   1380

ggcaaatcac gtgttacagg tgttaatcca gttcaaggtg aaccttgtcc tggtacaagg   1440

aaatgtgtcc gaacgcttaa ttgaaaaatg tataaacagt aagcggttgg taatcggctc   1500

agtgaatggc agtgtgatgc aggcttttgc agaggctgca ggagcagtac aggtggccta   1560

cattacacaa gtgaatgaag attgtgtggg cgacggggtc tgcgtgacct tctggagaag   1620

cagccctttg gatgttgtag ataggaacaa cagaatcgca atcttattaa aaacagaagg   1680

aattaatttg gttacggccg tgctcactaa cccagttact gcacagatgc aaatcaaaga   1740

agataggttc tggacatgtg cctatcgttt gtattatgct ctaaaagagg aaaaggtctt   1800

ccttggaggt ggtgcagttg aatttttgtg tcttagctgt cttcatattc ttgcagagca   1860

atctctgaaa aaagaaaacc atgcctgctc agggtggctg cataatactt cctcttggct   1920

ggcttcatct ctggcaatat acagaccaac tgtgcttaaa ttcctggcaa atggatggca   1980

gaaatacctt tcaactctcc tatataacac tgccaattac tcatcagaat ttgaagccag   2040

cacatacatt caacatcatc tgcaaaatgc cacagactct ggctctcctt catcttacat   2100

cttgaatgaa tatagtaaac taaatagtag aatttttaat tcagacattt caaataaact   2160

ggagcagatt ccgagagttt atgacgttgt tacaccaaag attgaggcgt ggcgccgagc   2220

attggattta gtattgttag tacttcagac agacagtgaa ataattactg gacatggaca   2280

cacacagata aattcacagg aattaacggg ctttctattt ttgtagtgtt actggctaag   2340

tctttggaaa ataatttttc ataatatgtc atgctaataa taaatatatt gatagccaag   2400

tcatggtgcc taaaatgcca gctattgcca agaagaaaat agttgatgtc tgtcaataac   2460

tgtgcatggt ctgagatttt accctactta taagctaaca agttagcctg ttactgtttc   2520

gtgggatgct acagaatgca taagacacct gggtcagaaa caaaggactt atcgctcaca   2580

gcaaaagctg tagccagagc ttcatgttgg ttttattcag ttcctcattt ttctagttcc   2640

cacaggagga acacaaaggg cccatgatga aagcctgcac acagtgggtt atgttgtaag   2700

cttgggttat taactgcttt tatagtaagc aaaaaaatcc tggtctttgt ccaaagggag   2760

ttattacccc atacttgaag atagcttagt gtaaacacaa gcctaggaca tggactaggt   2820

aaagacaaag tccttgcatt cttgacatac ccagtaagta tgcagggaca ctcagagccc   2880

atagtggata gtctcttcca acagtctgct cctcagcctg agatgttctt ggccaaactt   2940

gaattttcac atgagtatgc cactctatca gctactctga ttaacctgac agtcgggttg   3000

tttagtcagt accaaatttg ttcatttggt ctcatatagc aattaatgca ggctattatc   3060

agacacagca gcaggatgaa gccaacctgc agtattaacc tcagtcctgt cccccaaggt   3120

cttgactcaa tcaactctaa gttccaaggg aggaccaata ggtcttttta ttaggcagcc   3180

agaatgtagt gaaggacaat ttattatact ttatgaccca ataaagggag ctttgactga   3240

cgtaaaaaaa aaaaaaaaaa                                               3260


<210>  302
<211>  710
<212>  PRT
<213>  Homosapiens

<400>  302

Met Val Met Ala Cys Arg Val Val Asn Lys Arg Arg His Met Gly Leu 
1               5                   10                  15      


Gln Gln Leu Ser Ser Phe Ala Glu Thr Gly Arg Thr Phe Leu Gly Pro 
            20                  25                  30          


Leu Lys Ser Ser Lys Phe Ile Ile Asp Glu Glu Cys His Glu Ser Val 
        35                  40                  45              


Leu Ile Ser Ser Thr Val Arg Leu Leu Glu Ser Leu Asp Leu Thr Ser 
    50                  55                  60                  


Ala Val Gly Gln Leu Leu Asn Glu Ala Val Gln Ala Gln Asn Asn Thr 
65                  70                  75                  80  


Tyr Arg Thr Gly Ile Ser Thr Leu Leu Phe Leu Val Gly Ala Trp Ser 
                85                  90                  95      


Ser Ala Val Glu Glu Cys Leu His Leu Gly Val Pro Ile Ser Ile Ile 
            100                 105                 110         


Val Ser Val Met Ser Glu Gly Leu Asn Phe Cys Ser Glu Glu Val Val 
        115                 120                 125             


Ser Leu His Val Pro Val His Asn Ile Phe Asp Cys Met Asp Ser Thr 
    130                 135                 140                 


Lys Thr Phe Ser Gln Leu Glu Thr Phe Ser Val Ser Leu Cys Pro Phe 
145                 150                 155                 160 


Leu Gln Val Pro Ser Asp Thr Asp Leu Ile Glu Glu Leu His Gly Leu 
                165                 170                 175     


Lys Asp Val Ala Ser Gln Thr Leu Thr Ile Ser Asn Leu Ser Gly Arg 
            180                 185                 190         


Pro Leu Lys Ser Tyr Glu Leu Phe Lys Pro Gln Thr Lys Val Glu Ala 
        195                 200                 205             


Asp Asn Asn Thr Ser Arg Thr Leu Lys Asn Ser Leu Leu Ala Asp Thr 
    210                 215                 220                 


Cys Cys Arg Gln Ser Ile Leu Ile His Ser Arg His Phe Asn Arg Thr 
225                 230                 235                 240 


Asp Asn Thr Glu Gly Val Ser Lys Pro Asp Gly Phe Gln Glu His Val 
                245                 250                 255     


Thr Ala Thr His Lys Thr Tyr Arg Cys Asn Asp Leu Val Glu Leu Ala 
            260                 265                 270         


Val Gly Leu Ser His Gly Asp His Ser Ser Met Lys Leu Val Glu Glu 
        275                 280                 285             


Ala Val Gln Leu Gln Tyr Gln Asn Ala Cys Val Gln Gln Gly Asn Cys 
    290                 295                 300                 


Thr Lys Pro Phe Met Phe Asp Ile Ser Arg Ile Phe Thr Cys Cys Leu 
305                 310                 315                 320 


Pro Gly Leu Pro Glu Thr Ser Ser Cys Val Cys Pro Gly Tyr Ile Thr 
                325                 330                 335     


Val Val Ser Val Ser Asn Asn Pro Val Ile Lys Glu Leu Gln Asn Gln 
            340                 345                 350         


Pro Val Arg Ile Val Leu Ile Glu Gly Asp Leu Thr Glu Asn Tyr Arg 
        355                 360                 365             


His Leu Gly Phe Asn Lys Ser Ala Asn Ile Lys Thr Val Leu Asp Ser 
    370                 375                 380                 


Met Arg Leu Gln Glu Asp Ser Ser Glu Glu Leu Trp Ala Asn His Val 
385                 390                 395                 400 


Leu Gln Val Leu Ile Gln Phe Lys Val Asn Leu Val Leu Val Gln Gly 
                405                 410                 415     


Asn Val Ser Glu Arg Leu Ile Glu Lys Cys Ile Asn Ser Lys Arg Leu 
            420                 425                 430         


Val Ile Gly Ser Val Asn Gly Ser Val Met Gln Ala Phe Ala Glu Ala 
        435                 440                 445             


Ala Gly Ala Val Gln Val Ala Tyr Ile Thr Gln Val Asn Glu Asp Cys 
    450                 455                 460                 


Val Gly Asp Gly Val Cys Val Thr Phe Trp Arg Ser Ser Pro Leu Asp 
465                 470                 475                 480 


Val Val Asp Arg Asn Asn Arg Ile Ala Ile Leu Leu Lys Thr Glu Gly 
                485                 490                 495     


Ile Asn Leu Val Thr Ala Val Leu Thr Asn Pro Val Thr Ala Gln Met 
            500                 505                 510         


Gln Ile Lys Glu Asp Arg Phe Trp Thr Cys Ala Tyr Arg Leu Tyr Tyr 
        515                 520                 525             


Ala Leu Lys Glu Glu Lys Val Phe Leu Gly Gly Gly Ala Val Glu Phe 
    530                 535                 540                 


Leu Cys Leu Ser Cys Leu His Ile Leu Ala Glu Gln Ser Leu Lys Lys 
545                 550                 555                 560 


Glu Asn His Ala Cys Ser Gly Trp Leu His Asn Thr Ser Ser Trp Leu 
                565                 570                 575     


Ala Ser Ser Leu Ala Ile Tyr Arg Pro Thr Val Leu Lys Phe Leu Ala 
            580                 585                 590         


Asn Gly Trp Gln Lys Tyr Leu Ser Thr Leu Leu Tyr Asn Thr Ala Asn 
        595                 600                 605             


Tyr Ser Ser Glu Phe Glu Ala Ser Thr Tyr Ile Gln His His Leu Gln 
    610                 615                 620                 


Asn Ala Thr Asp Ser Gly Ser Pro Ser Ser Tyr Ile Leu Asn Glu Tyr 
625                 630                 635                 640 


Ser Lys Leu Asn Ser Arg Ile Phe Asn Ser Asp Ile Ser Asn Lys Leu 
                645                 650                 655     


Glu Gln Ile Pro Arg Val Tyr Asp Val Val Thr Pro Lys Ile Glu Ala 
            660                 665                 670         


Trp Arg Arg Ala Leu Asp Leu Val Leu Leu Val Leu Gln Thr Asp Ser 
        675                 680                 685             


Glu Ile Ile Thr Gly His Gly His Thr Gln Ile Asn Ser Gln Glu Leu 
    690                 695                 700                 


Thr Gly Phe Leu Phe Leu 
705                 710 


<210>  303
<211>  6803
<212>  DNA
<213>  Homosapiens

<400>  303
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc     60

gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg    120

ggtgccagat tagcggacgc gctgcccgcg gttgcaacgg gatcccgggc gctgcagctt    180

gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc    240

gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga    300

ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc    360

ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc    420

gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga    480

gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc    540

acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc    600

ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc    660

aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta    720

tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg    780

aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg    840

tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag    900

ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat    960

ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat   1020

gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta   1080

accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata   1140

ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc   1200

tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa   1260

tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct   1320

tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt   1380

tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt   1440

aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat   1500

acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt   1560

cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg   1620

aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg   1680

tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa   1740

aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat   1800

tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct   1860

caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca   1920

agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata   1980

tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt   2040

aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt   2100

tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc   2160

ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa   2220

ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa   2280

tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat   2340

ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca   2400

aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt   2460

cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt   2520

ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa   2580

gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta   2640

ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg   2700

gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcatct gccatttttc   2760

aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa   2820

caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct   2880

gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg   2940

tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt   3000

ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa   3060

ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt   3120

gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat   3180

acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata   3240

tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg   3300

aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat   3360

ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgcttga aaataaatta   3420

tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc   3480

tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc   3540

agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta   3600

acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt   3660

atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat   3720

tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata   3780

ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac   3840

taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt   3900

ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat   3960

atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg   4020

tttcctggtg tttcctctga ctctagtgca ctgatgatct ctgataaggc tcagctgctt   4080

tatagttctc tggctaatgc agcagatact cttcctgcca gtggtaatac gattttttaa   4140

gaaggcagtt tgtcaatttt aatcttgtgg atacctttat actcttaggg tattatttta   4200

tacaaaagcc ttgaggattg cattctattt tctatatgac cctcttgata tttaaaaaac   4260

actatggata acaattcttc atttacctag tattatgaaa gaatgaagga gttcaaacaa   4320

atgtgtttcc cagttaacta gggtttactg tttgagccaa tataaatgtt taactgtttg   4380

tgatggcagt attcctaaag tacattgcat gttttcctaa atacagagtt taaataattt   4440

cagtaattct tagatgattc agcttcatca ttaagaatat cttttgtttt atgttgagtt   4500

agaaatgcct tcatatagac atagtctttc agacctctac tgtcagtttt catttctagc   4560

tgctttcagg gttttatgaa ttttcaggca aagctttaat ttatactaag cttaggaagt   4620

atggctaatg ccaacggcag tttttttctt cttaattcca catgactgag gcatatatga   4680

tctctgggta ggtgagttgt tgtgacaacc acaagcactt tttttttttt taaagaaaaa   4740

aaggtagtga atttttaatc atctggactt taagaaggat tctggagtat acttaggcct   4800

gaaattatat atatttggct tggaaatgtg tttttcttca attacatcta caagtaagta   4860

cagctgaaat tcagaggacc cataagagtt cacatgaaaa aaatcaattc atttgaaaag   4920

gcaagatgca ggagagagga agccttgcaa acctgcagac tgctttttgc ccaatataga   4980

ttgggtaagg ctgcaaaaca taagcttaat tagctcacat gctctgctct cacgtggcac   5040

cagtggatag tgtgagagaa ttaggctgta gaacaaatgg ccttctcttt cagcattcac   5100

accactacaa aatcatcttt tatatcaaca gaagaataag cataaactaa gcaaaaggtc   5160

aataagtacc tgaaaccaag attggctaga gatatatctt aatgcaatcc attttctgat   5220

ggattgttac gagttggcta tataatgtat gtatggtatt ttgatttgtg taaaagtttt   5280

aaaaatcaag ctttaagtac atggacattt ttaaataaaa tatttaaaga caatttagaa   5340

aattgcctta atatcattgt tggctaaata gaatagggga catgcatatt aaggaaaagg   5400

tcatggagaa ataatattgg tatcaaacaa atacattgat ttgtcatgat acacattgaa   5460

tttgatccaa tagtttaagg aataggtagg aaaatttggt ttctattttt cgatttcctg   5520

taaatcagtg acataaataa ttcttagctt attttatatt tccttgtctt aaatactgag   5580

ctcagtaagt tgtgttaggg gattatttct cagttgagac tttcttatat gacattttac   5640

tatgttttga cttcctgact attaaaaata aatagtagaa acaattttca taaagtgaag   5700

aattatataa tcactgcttt ataactgact ttattatatt tatttcaaag ttcatttaaa   5760

ggctactatt catcctctgt gatggaatgg tcaggaattt gttttctcat agtttaattc   5820

caacaacaat attagtcgta tccaaaataa cctttaatgc taaactttac tgatgtatat   5880

ccaaagcttc tccttttcag acagattaat ccagaagcag tcataaacag aagaataggt   5940

ggtatgttcc taatgatatt atttctacta atggaataaa ctgtaatatt agaaattatg   6000

ctgctaatta tatcagctct gaggtaattt ctgaaatgtt cagactcagt cggaacaaat   6060

tggaaaattt aaatttttat tcttagctat aaagcaagaa agtaaacaca ttaatttcct   6120

caacattttt aagccaatta aaaatataaa agatacacac caatatcttc ttcaggctct   6180

gacaggcctc ctggaaactt ccacatattt ttcaactgca gtataaagtc agaaaataaa   6240

gttaacataa ctttcactaa cacacacata tgtagatttc acaaaatcca cctataattg   6300

gtcaaagtgg ttgagaatat attttttagt aattgcatgc aaaatttttc tagcttccat   6360

cctttctccc tcgtttcttc tttttttggg ggagctggta actgatgaaa tcttttccca   6420

ccttttctct tcaggaaata taagtggttt tgtttggtta acgtgataca ttctgtatga   6480

atgaaacatt ggagggaaac atctactgaa tttctgtaat ttaaaatatt ttgctgctag   6540

ttaactatga acagatagaa gaatcttaca gatgctgcta taaataagta gaaaatataa   6600

atttcatcac taaaatatgc tattttaaaa tctatttcct atattgtatt tctaatcaga   6660

tgtattactc ttattatttc tattgtatgt gttaatgatt ttatgtaaaa atgtaattgc   6720

ttttcatgag tagtatgaat aaaattgatt agtttgtgtt ttcttgtctc ccgaaaaaaa   6780

aaaaaaaaaa aaaaaaaaaa aaa                                           6803


<210>  304
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  304

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Ala Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  305
<211>  1195
<212>  DNA
<213>  Homosapiens

<400>  305
tttgggcaac ggacgaatta agcggcgtgg agatgcggca gccactgagc tggggccgct     60

ggcgcgcgat gcttgcccga acctacggcc ccgggccttc ggcgggttac cgctgggcct    120

cgggcgcaca gggttacgtg cggaatccgc cagttggagc gtgcgatctg cagggcgagc    180

tggacagatt cgggggcatc tcggtgcgcc tggcgcggct cgatgcgctg gaccgcctgg    240

acgctgccgc cttccagaag ggcttgcagg ctgcagtaca gcaatggcga tcagaaggta    300

gaacagctgt atggctgcac attcccatcc tccaaagccg atttattgcc cctgctgctt    360

ccctgggctt ctgctttcac cacgcagaat cggattcatc aacgttgact ctgtggctga    420

gagaagggcc cagcagatta ccaggatatg cttcacatca agtaggagtt gcaggagctg    480

tatttgatga aagtactaga aaaatactgg ttgtacaaga tcgaaataaa ttgaaaaata    540

tgtggaagtt tccaggaggc ctgtcagagc ctgaagaaga tattggagac acagcggttc    600

gagaagtttt tgaagagact ggtataaaat cagaattcag gtccgtcctg agtattcggc    660

aacagcacac aaatcctgga gcttttggga agtcagatat gtatatcatc tgccgcctaa    720

agccatattc attcaccata aatttttgcc aggaagaatg cttaagatgt gagtggatgg    780

atctcaatga cctggcgaag actgaaaata caactcccat caccagcaga gttgctaggc    840

tgctgctgta tgggtacaga gaagggtttg acaaaattga cctgactgtg gaagaacttc    900

cagcagttta cacaggactg ttttataaac tctatcataa ggaactgcca gagaattata    960

aaactatgaa aggaattgat taaattcaca tttatatgtt tagaaacatg tagactaacg   1020

aatgacataa gaaatagtgg acattttgga ttgattaaac atctgactgt gattttctaa   1080

tgtatatgat ttccatgaag aaattttgtt tctaaacatg cacattttaa aagcctcttt   1140

tcgaataaag caaatgcgtg aaaaagaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        1195


<210>  306
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  306

Met Arg Gln Pro Leu Ser Trp Gly Arg Trp Arg Ala Met Leu Ala Arg 
1               5                   10                  15      


Thr Tyr Gly Pro Gly Pro Ser Ala Gly Tyr Arg Trp Ala Ser Gly Ala 
            20                  25                  30          


Gln Gly Tyr Val Arg Asn Pro Pro Val Gly Ala Cys Asp Leu Gln Gly 
        35                  40                  45              


Glu Leu Asp Arg Phe Gly Gly Ile Ser Val Arg Leu Ala Arg Leu Asp 
    50                  55                  60                  


Ala Leu Asp Arg Leu Asp Ala Ala Ala Phe Gln Lys Gly Leu Gln Ala 
65                  70                  75                  80  


Ala Val Gln Gln Trp Arg Ser Glu Gly Arg Thr Ala Val Trp Leu His 
                85                  90                  95      


Ile Pro Ile Leu Gln Ser Arg Phe Ile Ala Pro Ala Ala Ser Leu Gly 
            100                 105                 110         


Phe Cys Phe His His Ala Glu Ser Asp Ser Ser Thr Leu Thr Leu Trp 
        115                 120                 125             


Leu Arg Glu Gly Pro Ser Arg Leu Pro Gly Tyr Ala Ser His Gln Val 
    130                 135                 140                 


Gly Val Ala Gly Ala Val Phe Asp Glu Ser Thr Arg Lys Ile Leu Val 
145                 150                 155                 160 


Val Gln Asp Arg Asn Lys Leu Lys Asn Met Trp Lys Phe Pro Gly Gly 
                165                 170                 175     


Leu Ser Glu Pro Glu Glu Asp Ile Gly Asp Thr Ala Val Arg Glu Val 
            180                 185                 190         


Phe Glu Glu Thr Gly Ile Lys Ser Glu Phe Arg Ser Val Leu Ser Ile 
        195                 200                 205             


Arg Gln Gln His Thr Asn Pro Gly Ala Phe Gly Lys Ser Asp Met Tyr 
    210                 215                 220                 


Ile Ile Cys Arg Leu Lys Pro Tyr Ser Phe Thr Ile Asn Phe Cys Gln 
225                 230                 235                 240 


Glu Glu Cys Leu Arg Cys Glu Trp Met Asp Leu Asn Asp Leu Ala Lys 
                245                 250                 255     


Thr Glu Asn Thr Thr Pro Ile Thr Ser Arg Val Ala Arg Leu Leu Leu 
            260                 265                 270         


Tyr Gly Tyr Arg Glu Gly Phe Asp Lys Ile Asp Leu Thr Val Glu Glu 
        275                 280                 285             


Leu Pro Ala Val Tyr Thr Gly Leu Phe Tyr Lys Leu Tyr His Lys Glu 
    290                 295                 300                 


Leu Pro Glu Asn Tyr Lys Thr Met Lys Gly Ile Asp 
305                 310                 315     


<210>  307
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  307
agcagtcttt gaaacagctg taacggcatc tgtgaaagaa gataggttcc aggaacggaa     60

ctgccactta gattgtaaat tcctgaaaaa caggacgttt ttgcatctcc tcccggcttc    120

cccatcccta aaccaacgtc tgttgaatta aactaccaaa caaaataact gcagtacagc    180

aatggcgatc agaaggtaga acagctgtat ggctgcacat tcccatcctc caaagccgat    240

ttattgcccc tgctgcttcc ctgggcttct gctttcacca cgcagaatcg gattcatcaa    300

cgttgactct gtggctgaga gaagggccca gcagattacc aggatatgct tcacatcaag    360

taggagttgc aggagctgta tttgatgaaa gtactagaaa aatactggtt gtacaagatc    420

gaaataaatt gaaaaatatg tggaagtttc caggaggcct gtcagagcct gaagaagata    480

ttggagacac agcggttcga gaagtttttg aagagactgg tataaaatca gaattcaggt    540

ccgtcctgag tattcggcaa cagcacacaa atcctggagc ttttgggaag tcagatatgt    600

atatcatctg ccgcctaaag ccatattcat tcaccataaa tttttgccag gaagaatgct    660

taagatgtga gtggatggat ctcaatgacc tggcgaagac tgaaaataca actcccatca    720

ccagcagagt tgctaggctg ctgctgtatg ggtacagaga agggtttgac aaaattgacc    780

tgactgtgga agaacttcca gcagtttaca caggactgtt ttataaactc tatcataagg    840

aactgccaga gaattataaa actatgaaag gaattgatta aattcacatt tatatgttta    900

gaaacatgta gactaacgaa tgacataaga aatagtggac attttggatt gattaaacat    960

ctgactgtga ttttctaatg tatatgattt ccatgaagaa attttgtttc taaacatgca   1020

cattttaaaa gcctcttttc gaataaagca aatgcgtgaa aaagaaaaaa aaaaaaa      1077


<210>  308
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  308

Met Trp Lys Phe Pro Gly Gly Leu Ser Glu Pro Glu Glu Asp Ile Gly 
1               5                   10                  15      


Asp Thr Ala Val Arg Glu Val Phe Glu Glu Thr Gly Ile Lys Ser Glu 
            20                  25                  30          


Phe Arg Ser Val Leu Ser Ile Arg Gln Gln His Thr Asn Pro Gly Ala 
        35                  40                  45              


Phe Gly Lys Ser Asp Met Tyr Ile Ile Cys Arg Leu Lys Pro Tyr Ser 
    50                  55                  60                  


Phe Thr Ile Asn Phe Cys Gln Glu Glu Cys Leu Arg Cys Glu Trp Met 
65                  70                  75                  80  


Asp Leu Asn Asp Leu Ala Lys Thr Glu Asn Thr Thr Pro Ile Thr Ser 
                85                  90                  95      


Arg Val Ala Arg Leu Leu Leu Tyr Gly Tyr Arg Glu Gly Phe Asp Lys 
            100                 105                 110         


Ile Asp Leu Thr Val Glu Glu Leu Pro Ala Val Tyr Thr Gly Leu Phe 
        115                 120                 125             


Tyr Lys Leu Tyr His Lys Glu Leu Pro Glu Asn Tyr Lys Thr Met Lys 
    130                 135                 140                 


Gly Ile Asp 
145         


<210>  309
<211>  3359
<212>  DNA
<213>  Homosapiens

<400>  309
ttttctctca gttgaagcgc gcacattgag tcggcttttc tactgcttcg gctagggtac     60

cttgtgacca tgtcttccaa gaagaataga aagcggttga accaaagcgc ggaaaatggt    120

tcgtccttgc cctctgctgc ttcctcttgt gcggaggcac gggctccttc tgctggatca    180

gacttcgcgg caacctccgg gactctgacg gtgaccaact tattagaaaa ggtagatgac    240

aaaattccta aaacattcca gaatcccctt attcatcttg gactcaacac tatgaagtct    300

gcaaatatat gtataggtcg accagtgttg cttactagtt tgaacggaaa gcaagaggtg    360

tatacagcct ggcctatggc aggatttcct ggaggcaagg tcggcctgag tgaaatggca    420

cagaaaaatg tgggtgtgag gcctggtgat gccatccagg tccagcctct tgtgggtgct    480

gtgctacagg ctgaggaaat ggatgtggca ctgagtgaca aagatatgga aattaatgaa    540

gaagaactga ctggttgtat cctgagaaaa ctagatggca agattgtttt accaggcaac    600

tttctgtatt gtacattcta tggacgaccg tacaagctgc aagtattgcg agtgaaaggg    660

gcagatggca tgatattggg agggcctcag agtgaccctg acactgatgc ccaaagaatg    720

gcctttgaac agtccagcat ggaaaccagt agcctggagt tatccttaca gctaagccag    780

ttagatctgg aggataccca gatcccaaca tcaagaagta ctccttataa accaattgat    840

gacagaatta caaataaagc cagtgatgtt ttgctggatg ttacacagag ccctggagat    900

ggcagtggac ttatgctaga ggaagtcaca ggtcttaaat gtaattttga atctgccaga    960

gaaggaaatg agcaacttac tgaagaagag agactgctaa agttcagcat aggagcaaag   1020

tgcaatactg atacttttta ttttatttct tcaacaacaa gagtcaattt tacagagatt   1080

gataaaaatt caaaagagca agacaaccaa ttcaaagtaa cttatgacat gataggagga   1140

ttaagtagcc agctgaaagc aattagagaa ataattgaat tgcccctcaa acagcctgag   1200

cttttcaaga gttatggaat tcctgcccct agaggagtgt tactttatgg tcctccaggt   1260

actggaaaaa caatgatcgc cagggctgtt gctaatgaag ttggagccta tgtttctgta   1320

attaatggtc ctgaaattat aagcaaattc tatggtgaga ctgaagcaaa gttacgtcag   1380

atatttgctg aagccactct acgacaccca tcaattattt ttattgatga gctggatgca   1440

ctttgtccga aaagagaggg ggcccagaat gaagtggaaa aaagagttgt ggcttcactc   1500

ttaacactga tggatggcat tggttcagaa gtaagtgaag gacaagtgtt ggttcttggg   1560

gccacaaatc gccctcatgc cttggatgct gctctccgaa gacctgggcg atttgataaa   1620

gagattgaga ttggagttcc caatgctcag gaccggctag atattctcca gaaactgctt   1680

cgaagggtac cccatttgct cactgaggct gagctgctgc agctggcaaa tagtgctcat   1740

ggatacgttg gagcagactt gaaagtcttg tgtaatgaag caggtctctg tgccttgcgg   1800

agaatcctga aaaaacagcc taacctccct gatgtcaagg tggctggact ggtgaagatt   1860

actctgaagg atttctttca ggcaatgaat gatatcagac ccagcgccat gagggaaata   1920

gcaattgatg tcccaaatgt atcctggtca gatataggag gactggaaag tatcaaactg   1980

aagttggaac aggctgtgga atggccctta aaacatccag agtctttcat tcgaatgggt   2040

attcagccac ctaaaggagt tcttctctat gggccacctg ggtgctctaa aacaatgata   2100

gcaaaggctt tggccaatga gagtggactg aattttctag ctataaaggg gcctgaatta   2160

atgaataaat atgttggtga atccgaaaga gcagttagag agaccttccg aaaagcaaga   2220

gcagtggcgc cttccattat tttctttgat gaactggatg ccttagcagt tgaaaggggc   2280

agttctttag gtgctgggaa tgtagccgat cgtgttttgg ctcagctctt aacagaaatg   2340

gatgggattg aacagctaaa ggatgtgacc attttggcag ctactaaccg tccagatagg   2400

atagacaagg ctttgatgcg gcctggaaga attgatagaa tcatctatgt gcctttaccg   2460

gatgcagcaa caagaaggga aatatttaag ctgcagttcc actccatgcc tgtcagtaat   2520

gaagttgacc tggatgaact catccttcaa accgacgcat actcaggagc agagattgta   2580

gctgtctgca gagaggcagc tcttctggct ctggaagaag gcattcaagc caatctcatc   2640

atgaaaagac atttcactca ggccttgagc actgtgacac ctagaattcc tgagtcattg   2700

agacgttttt atgaagatta tcaagagaag agtgggctgc gtacactctg agaaaatata   2760

tatattcaag atgctgaaaa tcctttccag agaaaatttg tttcttttta aaattttttg   2820

agagtgttaa aaaaaatttt actaggcaaa atgtttgaag tatgttcagt agaatttagg   2880

ggctttggtt cttacagatt ttcaagtcat gtaagtacag tgaagatatc tctgagcata   2940

agtttcaatc agttttacct ggaaatttgt ggtgtggttt aaaaaacaaa tgtttagctt   3000

tttcatttgc gacctagtct gttcatccca tgaagcaatt tctttttcca gaatctgttt   3060

gagtgtcttt ctaaaatgcc aaacatgttg gcatcaattt tatacaggga tataaaaaag   3120

tatatgtgga taaatttttt gtaatcttta gggatataaa aaagtgtatg tggataaatt   3180

ttttgtaatc tttatttttg aaggccagcc agtaaaatgg cccaatgtgc cagccatgct   3240

tatgtggcct tgttttcaaa tatacatata tgtgttatca ttaaaattca tatatgtatt   3300

tttgttttag ccctcttaat ctctacctat ggccaaaaaa aaaaaaaaaa aaaaaaaaa    3359


<210>  310
<211>  893
<212>  PRT
<213>  Homosapiens

<400>  310

Met Ser Ser Lys Lys Asn Arg Lys Arg Leu Asn Gln Ser Ala Glu Asn 
1               5                   10                  15      


Gly Ser Ser Leu Pro Ser Ala Ala Ser Ser Cys Ala Glu Ala Arg Ala 
            20                  25                  30          


Pro Ser Ala Gly Ser Asp Phe Ala Ala Thr Ser Gly Thr Leu Thr Val 
        35                  40                  45              


Thr Asn Leu Leu Glu Lys Val Asp Asp Lys Ile Pro Lys Thr Phe Gln 
    50                  55                  60                  


Asn Pro Leu Ile His Leu Gly Leu Asn Thr Met Lys Ser Ala Asn Ile 
65                  70                  75                  80  


Cys Ile Gly Arg Pro Val Leu Leu Thr Ser Leu Asn Gly Lys Gln Glu 
                85                  90                  95      


Val Tyr Thr Ala Trp Pro Met Ala Gly Phe Pro Gly Gly Lys Val Gly 
            100                 105                 110         


Leu Ser Glu Met Ala Gln Lys Asn Val Gly Val Arg Pro Gly Asp Ala 
        115                 120                 125             


Ile Gln Val Gln Pro Leu Val Gly Ala Val Leu Gln Ala Glu Glu Met 
    130                 135                 140                 


Asp Val Ala Leu Ser Asp Lys Asp Met Glu Ile Asn Glu Glu Glu Leu 
145                 150                 155                 160 


Thr Gly Cys Ile Leu Arg Lys Leu Asp Gly Lys Ile Val Leu Pro Gly 
                165                 170                 175     


Asn Phe Leu Tyr Cys Thr Phe Tyr Gly Arg Pro Tyr Lys Leu Gln Val 
            180                 185                 190         


Leu Arg Val Lys Gly Ala Asp Gly Met Ile Leu Gly Gly Pro Gln Ser 
        195                 200                 205             


Asp Pro Asp Thr Asp Ala Gln Arg Met Ala Phe Glu Gln Ser Ser Met 
    210                 215                 220                 


Glu Thr Ser Ser Leu Glu Leu Ser Leu Gln Leu Ser Gln Leu Asp Leu 
225                 230                 235                 240 


Glu Asp Thr Gln Ile Pro Thr Ser Arg Ser Thr Pro Tyr Lys Pro Ile 
                245                 250                 255     


Asp Asp Arg Ile Thr Asn Lys Ala Ser Asp Val Leu Leu Asp Val Thr 
            260                 265                 270         


Gln Ser Pro Gly Asp Gly Ser Gly Leu Met Leu Glu Glu Val Thr Gly 
        275                 280                 285             


Leu Lys Cys Asn Phe Glu Ser Ala Arg Glu Gly Asn Glu Gln Leu Thr 
    290                 295                 300                 


Glu Glu Glu Arg Leu Leu Lys Phe Ser Ile Gly Ala Lys Cys Asn Thr 
305                 310                 315                 320 


Asp Thr Phe Tyr Phe Ile Ser Ser Thr Thr Arg Val Asn Phe Thr Glu 
                325                 330                 335     


Ile Asp Lys Asn Ser Lys Glu Gln Asp Asn Gln Phe Lys Val Thr Tyr 
            340                 345                 350         


Asp Met Ile Gly Gly Leu Ser Ser Gln Leu Lys Ala Ile Arg Glu Ile 
        355                 360                 365             


Ile Glu Leu Pro Leu Lys Gln Pro Glu Leu Phe Lys Ser Tyr Gly Ile 
    370                 375                 380                 


Pro Ala Pro Arg Gly Val Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys 
385                 390                 395                 400 


Thr Met Ile Ala Arg Ala Val Ala Asn Glu Val Gly Ala Tyr Val Ser 
                405                 410                 415     


Val Ile Asn Gly Pro Glu Ile Ile Ser Lys Phe Tyr Gly Glu Thr Glu 
            420                 425                 430         


Ala Lys Leu Arg Gln Ile Phe Ala Glu Ala Thr Leu Arg His Pro Ser 
        435                 440                 445             


Ile Ile Phe Ile Asp Glu Leu Asp Ala Leu Cys Pro Lys Arg Glu Gly 
    450                 455                 460                 


Ala Gln Asn Glu Val Glu Lys Arg Val Val Ala Ser Leu Leu Thr Leu 
465                 470                 475                 480 


Met Asp Gly Ile Gly Ser Glu Val Ser Glu Gly Gln Val Leu Val Leu 
                485                 490                 495     


Gly Ala Thr Asn Arg Pro His Ala Leu Asp Ala Ala Leu Arg Arg Pro 
            500                 505                 510         


Gly Arg Phe Asp Lys Glu Ile Glu Ile Gly Val Pro Asn Ala Gln Asp 
        515                 520                 525             


Arg Leu Asp Ile Leu Gln Lys Leu Leu Arg Arg Val Pro His Leu Leu 
    530                 535                 540                 


Thr Glu Ala Glu Leu Leu Gln Leu Ala Asn Ser Ala His Gly Tyr Val 
545                 550                 555                 560 


Gly Ala Asp Leu Lys Val Leu Cys Asn Glu Ala Gly Leu Cys Ala Leu 
                565                 570                 575     


Arg Arg Ile Leu Lys Lys Gln Pro Asn Leu Pro Asp Val Lys Val Ala 
            580                 585                 590         


Gly Leu Val Lys Ile Thr Leu Lys Asp Phe Phe Gln Ala Met Asn Asp 
        595                 600                 605             


Ile Arg Pro Ser Ala Met Arg Glu Ile Ala Ile Asp Val Pro Asn Val 
    610                 615                 620                 


Ser Trp Ser Asp Ile Gly Gly Leu Glu Ser Ile Lys Leu Lys Leu Glu 
625                 630                 635                 640 


Gln Ala Val Glu Trp Pro Leu Lys His Pro Glu Ser Phe Ile Arg Met 
                645                 650                 655     


Gly Ile Gln Pro Pro Lys Gly Val Leu Leu Tyr Gly Pro Pro Gly Cys 
            660                 665                 670         


Ser Lys Thr Met Ile Ala Lys Ala Leu Ala Asn Glu Ser Gly Leu Asn 
        675                 680                 685             


Phe Leu Ala Ile Lys Gly Pro Glu Leu Met Asn Lys Tyr Val Gly Glu 
    690                 695                 700                 


Ser Glu Arg Ala Val Arg Glu Thr Phe Arg Lys Ala Arg Ala Val Ala 
705                 710                 715                 720 


Pro Ser Ile Ile Phe Phe Asp Glu Leu Asp Ala Leu Ala Val Glu Arg 
                725                 730                 735     


Gly Ser Ser Leu Gly Ala Gly Asn Val Ala Asp Arg Val Leu Ala Gln 
            740                 745                 750         


Leu Leu Thr Glu Met Asp Gly Ile Glu Gln Leu Lys Asp Val Thr Ile 
        755                 760                 765             


Leu Ala Ala Thr Asn Arg Pro Asp Arg Ile Asp Lys Ala Leu Met Arg 
    770                 775                 780                 


Pro Gly Arg Ile Asp Arg Ile Ile Tyr Val Pro Leu Pro Asp Ala Ala 
785                 790                 795                 800 


Thr Arg Arg Glu Ile Phe Lys Leu Gln Phe His Ser Met Pro Val Ser 
                805                 810                 815     


Asn Glu Val Asp Leu Asp Glu Leu Ile Leu Gln Thr Asp Ala Tyr Ser 
            820                 825                 830         


Gly Ala Glu Ile Val Ala Val Cys Arg Glu Ala Ala Leu Leu Ala Leu 
        835                 840                 845             


Glu Glu Gly Ile Gln Ala Asn Leu Ile Met Lys Arg His Phe Thr Gln 
    850                 855                 860                 


Ala Leu Ser Thr Val Thr Pro Arg Ile Pro Glu Ser Leu Arg Arg Phe 
865                 870                 875                 880 


Tyr Glu Asp Tyr Gln Glu Lys Ser Gly Leu Arg Thr Leu 
                885                 890             


<210>  311
<211>  2670
<212>  DNA
<213>  Homosapiens

<400>  311
ggccgagccg gaagaccctc tctttcgctg tttgagagtc tctcggctca aggaccggga     60

ggtaagaggt ttgggactgc cccggcaact ccagggtgtc tggtccacga cctatcctag    120

gcgccatggg tgtgataggt atacagctgg ttgttaccat ggtgatggcc agtgtcatgc    180

agaagattat acctcactat tctcttgctc gatggctact ctgtaatggc agtttgaggt    240

ggtatcaaca tcctacagaa gaagaattaa gaattcttgc agggaaacaa caaaaaggga    300

aaaccaaaaa agataggaaa tataatggtc acattgaaag taagccatta accattccaa    360

aggatattga ccttcatcta gaaacaaagt cagttacaga agtggatact ttagcattgc    420

attactttcc agaataccag tggctggtgg atttcacagt ggctgctaca gttgtgtatc    480

tagtaactga agtctactac aattttatga agcctacaca ggaaatgaat atcagcttag    540

tctggtgcct acttgttttg tcttttgcaa tcaaagttct attttcatta actacacact    600

attttaaagt agaagatggt ggtgaaagat ctgtttgtgt cacctttgga ttttttttct    660

ttgtcaaagc aatggcagtg ttgattgtaa cagaaaatta tctggaattt ggacttgaaa    720

cagggtttac aaatttttca gacagtgcga tgcagtttct tgaaaagcaa ggtttagaat    780

ctcagagtcc tgtttcaaaa cttactttca aatttttcct ggctattttc tgttcattca    840

ttggggcttt tttgacattt cctggattac gactggctca aatgcatctg gatgccctga    900

atttggcaac agaaaaaatt acacaaactt tacttcatat caacttcttg gcacctttat    960

ttatggtttt gctctgggta aaaccaatca ccaaagacta cattatgaac ccaccactgg   1020

gcaaagaaag tatcccttta atgacagaag ccacattcga tactctgcga ctctggttaa   1080

taatcctgct gtgtgctttg cggttggcca tgatgcgtag tcacctgcaa gcttatttaa   1140

atttagccca aaaatgtgtg gatcagatga agaaagaagc ggggcgaata agcacggttg   1200

agctacagaa aatggtggct cgagtctttt attatctttg tgtcattgca ctgcagtatg   1260

tggcgcctct ggtaatgctg cttcacacaa ctctgctttt gaaaacacta ggtaatcatt   1320

cctggggtat ttatccagaa tctatctcta ccttaccagt ggataatagt ctactgtcca   1380

attctgttta ctctgaatta ccatcagctg aagggaaaat gaaggtaact gttacacaaa   1440

taacagtggc actgagcagc ttaaaaaata tttttactcc tcttcttttt cgaggacttc   1500

tgtcttttct gacctggtgg attgctgctt gcctcttttc tacaagcctt tttgggcttt   1560

tctatcacca gtatctgact gtggcatgaa tctcagttaa caaaaaagca tatccaaatc   1620

accctttaaa ttaaaatatc tgtgccctta aagggctgat gaaaaccaga agaaagcaaa   1680

tacaatggga aaaaaaaaca tatcagaatg tcttgtatta aatgtttcct ctgtattctc   1740

agggtgaatt aatgtagtaa tatttaaaat tacaaaatag attgttaact gttacactgt   1800

ggcattggaa ttttaactct ttgtatttac tggtatgaga gggctatcta caagggtaat   1860

atttctgatt accctggttt acagaaacct ccagcagtct ttgaaacatc tcacatgact   1920

ctagttattg attgctttta atggttttat ggtactgttg atagtcatag tggctgccta   1980

tagaacaatc ttcaaactga gccatgcttt aggggaggga aaggggctaa agtctcttct   2040

gttggtaatt tattagttac tcttgaaaca gtaaaatcca acagaaagga agagatagct   2100

actgtatatt acagtaaaga aagctgcata gttattttaa atttaatgga gatgaatatg   2160

gttaaaatat ataactactg ctgcttgaga atagcaagag tattgtttta aaacatattc   2220

cacccaactt gagagttctt ttaaaatgat tggccatatg aacatttgta atcttgccat   2280

taggtttgga cctgccatat tttgttttat tctgtgatcc taactagttc cttttaatag   2340

gctaaaatat ttatcaatac tgatcagact ttaaagaaat tactttgtaa acctgctgac   2400

tacctgtatg tattgtatat atattatata ttaaatatat aatatattga gattataaaa   2460

gatgaaaata ttgaatcctt ataatatttt aagttgcaga atgtatgtta aaaagtgact   2520

tgaatgagat gtatttgtat ctagaaattt tatttctttt tggaatgaga ttaaaataca   2580

ttttgaaagt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2640

aaaaaaaaaa aaaccaaaaa aaaaaaaaaa                                    2670


<210>  312
<211>  487
<212>  PRT
<213>  Homosapiens

<400>  312

Met Gly Val Ile Gly Ile Gln Leu Val Val Thr Met Val Met Ala Ser 
1               5                   10                  15      


Val Met Gln Lys Ile Ile Pro His Tyr Ser Leu Ala Arg Trp Leu Leu 
            20                  25                  30          


Cys Asn Gly Ser Leu Arg Trp Tyr Gln His Pro Thr Glu Glu Glu Leu 
        35                  40                  45              


Arg Ile Leu Ala Gly Lys Gln Gln Lys Gly Lys Thr Lys Lys Asp Arg 
    50                  55                  60                  


Lys Tyr Asn Gly His Ile Glu Ser Lys Pro Leu Thr Ile Pro Lys Asp 
65                  70                  75                  80  


Ile Asp Leu His Leu Glu Thr Lys Ser Val Thr Glu Val Asp Thr Leu 
                85                  90                  95      


Ala Leu His Tyr Phe Pro Glu Tyr Gln Trp Leu Val Asp Phe Thr Val 
            100                 105                 110         


Ala Ala Thr Val Val Tyr Leu Val Thr Glu Val Tyr Tyr Asn Phe Met 
        115                 120                 125             


Lys Pro Thr Gln Glu Met Asn Ile Ser Leu Val Trp Cys Leu Leu Val 
    130                 135                 140                 


Leu Ser Phe Ala Ile Lys Val Leu Phe Ser Leu Thr Thr His Tyr Phe 
145                 150                 155                 160 


Lys Val Glu Asp Gly Gly Glu Arg Ser Val Cys Val Thr Phe Gly Phe 
                165                 170                 175     


Phe Phe Phe Val Lys Ala Met Ala Val Leu Ile Val Thr Glu Asn Tyr 
            180                 185                 190         


Leu Glu Phe Gly Leu Glu Thr Gly Phe Thr Asn Phe Ser Asp Ser Ala 
        195                 200                 205             


Met Gln Phe Leu Glu Lys Gln Gly Leu Glu Ser Gln Ser Pro Val Ser 
    210                 215                 220                 


Lys Leu Thr Phe Lys Phe Phe Leu Ala Ile Phe Cys Ser Phe Ile Gly 
225                 230                 235                 240 


Ala Phe Leu Thr Phe Pro Gly Leu Arg Leu Ala Gln Met His Leu Asp 
                245                 250                 255     


Ala Leu Asn Leu Ala Thr Glu Lys Ile Thr Gln Thr Leu Leu His Ile 
            260                 265                 270         


Asn Phe Leu Ala Pro Leu Phe Met Val Leu Leu Trp Val Lys Pro Ile 
        275                 280                 285             


Thr Lys Asp Tyr Ile Met Asn Pro Pro Leu Gly Lys Glu Ser Ile Pro 
    290                 295                 300                 


Leu Met Thr Glu Ala Thr Phe Asp Thr Leu Arg Leu Trp Leu Ile Ile 
305                 310                 315                 320 


Leu Leu Cys Ala Leu Arg Leu Ala Met Met Arg Ser His Leu Gln Ala 
                325                 330                 335     


Tyr Leu Asn Leu Ala Gln Lys Cys Val Asp Gln Met Lys Lys Glu Ala 
            340                 345                 350         


Gly Arg Ile Ser Thr Val Glu Leu Gln Lys Met Val Ala Arg Val Phe 
        355                 360                 365             


Tyr Tyr Leu Cys Val Ile Ala Leu Gln Tyr Val Ala Pro Leu Val Met 
    370                 375                 380                 


Leu Leu His Thr Thr Leu Leu Leu Lys Thr Leu Gly Asn His Ser Trp 
385                 390                 395                 400 


Gly Ile Tyr Pro Glu Ser Ile Ser Thr Leu Pro Val Asp Asn Ser Leu 
                405                 410                 415     


Leu Ser Asn Ser Val Tyr Ser Glu Leu Pro Ser Ala Glu Gly Lys Met 
            420                 425                 430         


Lys Val Thr Val Thr Gln Ile Thr Val Ala Leu Ser Ser Leu Lys Asn 
        435                 440                 445             


Ile Phe Thr Pro Leu Leu Phe Arg Gly Leu Leu Ser Phe Leu Thr Trp 
    450                 455                 460                 


Trp Ile Ala Ala Cys Leu Phe Ser Thr Ser Leu Phe Gly Leu Phe Tyr 
465                 470                 475                 480 


His Gln Tyr Leu Thr Val Ala 
                485         


<210>  313
<211>  4077
<212>  DNA
<213>  Homosapiens

<400>  313
gaattcccag ctctctgctc gctctgctcg cagtcacaga cacttgagca cacgcgtaca     60

cccagacatc ttcgggctgc tattggattg actttgaagg ttctgtgtgg gtcgccgtgg    120

ctgcatgttt gaatcaggtg gagaagcact tcaacgctgg acgaagtaaa gattattgtt    180

gttatttttt ttttctctct ctctctctct taagaaagga aaatatccca aggactaatc    240

tgatcgggtc ttccttcatc aggaacgaat gcaggaattt gggaactgag ctgtgcaagt    300

gctgaagaag gagatttgtt tggaggaaac aggaaagaga aagaaaagga aggaaaaaat    360

acataatttc agggacgaga gagagaagaa aaacggggac tatggggaga aaaaagattc    420

agattacgag gattatggat gaacgtaaca gacaggtgac atttacaaag aggaaatttg    480

ggttgatgaa gaaggcttat gagctgagcg tgctgtgtga ctgtgagatt gcgctgatca    540

tcttcaacag caccaacaag ctgttccagt atgccagcac cgacatggac aaagtgcttc    600

tcaagtacac ggagtacaac gagccgcatg agagccggac aaactcagac atcgtggaga    660

cgttgagaaa gaagggcctt aatggctgtg acagcccaga ccccgatgcg gacgattccg    720

taggtcacag ccctgagtct gaggacaagt acaggaaaat taacgaagat attgatctaa    780

tgatcagcag gcaaagattg tgtgctgttc cacctcccaa cttcgagatg ccagtctcca    840

tcccagtgtc cagccacaac agtttggtgt acagcaaccc tgtcagctca ctgggaaacc    900

ccaacctatt gccactggct cacccttctc tgcagaggaa tagtatgtct cctggtgtaa    960

cacatcgacc tccaagtgca ggtaacacag gtggtctgat gggtggagac ctcacgtctg   1020

gtgcaggcac cagtgcaggg aacgggtatg gcaatccccg aaactcacca ggtctgctgg   1080

tctcacctgg taacttgaac aagaatatgc aagcaaaatc tcctccccca atgaatttag   1140

gaatgaataa ccgtaaacca gatctccgag ttcttattcc accaggcagc aagaatacga   1200

tgccatcagt gtctgaggat gtcgacctgc ttttgaatca aaggataaat aactcccagt   1260

cggctcagtc attggctacc ccagtggttt ccgtagcaac tcctacttta ccaggacaag   1320

gaatgggagg atatccatca gccatttcaa caacatatgg taccgagtac tctctgagta   1380

gtgcagacct gtcatctctg tctgggttta acaccgccag cgctcttcac cttggttcag   1440

taactggctg gcaacagcaa cacctacata acatgccacc atctgccctc agtcagttgg   1500

gagcttgcac tagcactcat ttatctcaga gttcaaatct ctccctgcct tctactcaaa   1560

gcctcaacat caagtcagaa cctgtttctc ctcctagaga ccgtaccacc accccttcga   1620

gatacccaca acacacgcgc cacgaggcgg ggagatctcc tgttgacagc ttgagcagct   1680

gtagcagttc gtacgacggg agcgaccgag aggatcaccg gaacgaattc cactccccca   1740

ttggactcac cagaccttcg ccggacgaaa gggaaagtcc ctcagtcaag cgcatgcgac   1800

tttctgaagg atgggcaaca tgatcagatt attacttact agtttttttt tttttcttgc   1860

agtgtgtgtg tgtgctatac cttaatgggg aaggggggtc gatatgcatt atatgtgccg   1920

tgtgtggaaa aaaaaaaagt caggtactct gttttgtaaa agtactttta aattgcctca   1980

gtgatacagt ataaagataa acagaaatgc tgagataagc ttagcacttg agttgtacaa   2040

cagaacactt gtacaaaata gattttaagg ctaacttctt ttcactgttg tgctcctttg   2100

caaaatgtat gttacaatag atagtgtcat gttgcaggtt caacgttatt tacatgtaaa   2160

tagacaaaag gaaacatttg ccaaaagcgg cagatcttta ctgaaagaga gagcagctgt   2220

tatgcaacat atagaaaaat gtatagatgc ttggacagac ccggtaatgg gtggccattg   2280

gtaaatgtta ggaacacacc aggtcacctg acatcccaag aatgctcaca aacctgcagg   2340

catatcattg gcgtatggca ctcattaaaa aggatcagag accattaaaa gaggaccata   2400

cctattaaaa aaaaatgtgg agttggaggg ctaacatatt taattaaata aataaataaa   2460

tctgggtctg catctcttat taaataaaaa tataaaaata tgtacattac attttgctta   2520

ttttcatata aaaggtaaga cagagtttgc aaagcatttg tggctttttg tagtttactt   2580

aagccaaaat gtgttttttt ccccttgata gcttcgctaa tattttaaac agtcctgtaa   2640

aaaaccaaaa aggacttttt gtatagaaag cactacccta agccatgaag aactccatgc   2700

tttgctaacc aagataactg ttttctcttt gtagaagttt tgtttttgaa atgtgtattt   2760

ctaattatat aaaatattaa gaatctttta aaaaaatctg tgaaattaac atgcttgtgt   2820

atagctttct aatatatata atattatggt aatagcagaa gttttgttat cttaatagcg   2880

ggaggggggt atatttgtgc agttgcacat ttgagtaact attttctttc tgttttcttt   2940

tactctgctt acattttata agtttaaggt cagctgtcaa aaggataacc tgtggggtta   3000

gaacatatca cattgcaaca ccctaaattg tttttaatac attagcaatc tattgggtca   3060

actgacatcc attgtatata ctagtttctt tcatgctatt tttattttgt tttttgcatt   3120

tttatcaaat gcagggcccc tttctgatct caccatttca ccatgcatct tggaattcag   3180

taagtgcata tcctaacttg cccatattct aaatcatctg gttggttttc agcctagaat   3240

ttgatacgct ttttagaaat atgcccagaa tagaaaagct atgttggggc acatgtcctg   3300

caaatatggc cctagaaaca agtgatatgg aatttacttg gtgaataagt tataaattcc   3360

cacagaagaa aaatgtgaaa gactgggtgc tagacaagaa ggaagcaggt aaagggatag   3420

ttgctttgtc atccgttttt aattatttta actgaccctt gacaatcttg tcagcaatat   3480

aggactgttg aacaatcccg gtgtgtcagg acccccaaat gtcacttctg cataaagcat   3540

gtatgtcatc tattttttct tcaataaaga gatttaatag ccatttcaag aaatcccata   3600

aagaacctct ctatgtccct ttttttaatt taaaaaaatg actcttgtct aatattcgtc   3660

tataagggat taattttcag accctttaat aagtgagtgc cataagaaag tcaatatata   3720

ttgtttaaaa gatatttcag tctaggaaag attttccttc tcttggaatg tgaagatctg   3780

tcgattcatc tccaatcata tgcattgaca tacacagcaa agaagatata ggcagtaata   3840

tcaacactgc tatatcatgt gtaggacatt tcttatccat tttttctctt ttacttgcat   3900

agttgctatg tgtttctcat tgtaaaaggc tgccgctggg tggcagaagc caagagacct   3960

tattaactag gctatatttt tcttaacttg atctgaaatc cacaattaga ccacaatgca   4020

cctttggttg tatccataaa ggatgctagc ctgccttgta ctaatgtttt atatatt      4077


<210>  314
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  314

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  315
<211>  760
<212>  DNA
<213>  Homosapiens

<400>  315
gatggggctt ttttccagat cttcgcgccg agagccgggg acggccaacc tgccggcatg     60

cgataaaggc cggggaatgt ctagctgggg ccgcgctgag ccgagtgcgg acccgctttg    120

tgtgcgcgtt tgtttgtctc cgctgcggtc cgaaccgctg ccgcgacccc cgaggaggcg    180

gggcctccgc gcgcccggct ccgcctggtg agggtttcac ggcctctgct gccgccgccg    240

ccgccctcgt ttgttccgtt agatcgcgca gccccgaccg ctgcacccgg atcctagcaa    300

gccgggcgag gctgcccggg agccctcgat ggccttcatt tcacccaagc ccgcttcttg    360

ctttccccgg cgcttcccct cttttcctgg ttaacagctt atgggcgggg agctcggcaa    420

aactcagact aaaaacagaa aaagagaaaa gaaaggacaa attcgataca cccgcgtcgg    480

tcctccagag tttgtgaagg ggtgtaaaca tgtcggagtc tggggagatg agtgaatttg    540

gctacatcat ggaattgata gctaaaggca agatgccgga ttggagacga ggctaccgct    600

gcagacaggg ctgtgggaag acgacggaac ttgccacagc gacagacttc tcccaaacag    660

gaaataaaag tgggaagcat tttaaaacct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                          760


<210>  316
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  316

Met Ser Glu Ser Gly Glu Met Ser Glu Phe Gly Tyr Ile Met Glu Leu 
1               5                   10                  15      


Ile Ala Lys Gly Lys Met Pro Asp Trp Arg Arg Gly Tyr Arg Cys Arg 
            20                  25                  30          


Gln Gly Cys Gly Lys Thr Thr Glu Leu Ala Thr Ala Thr Asp Phe Ser 
        35                  40                  45              


Gln Thr Gly Asn Lys Ser Gly Lys His Phe Lys Thr 
    50                  55                  60  


<210>  317
<211>  906
<212>  DNA
<213>  Homosapiens

<400>  317
gatggggctt ttttccagat cttcgcgccg agagccgggg acggccaacc tgccggcatg     60

cgataaaggc cggggaatgt ctagctgggg ccgcgctgag ccgagtgcgg acccgctttg    120

tgtgcgcgtt tgtttgtctc cgctgcggtc cgaaccgctg ccgcgacccc cgaggaggcg    180

gggcctccgc gcgcccggct ccgcctggtg agggtttcac ggcctctgct gccgccgccg    240

ccgccctcgt ttgttccgtt agatcgcgca gccccgaccg ctgcacccgg atcctagcaa    300

gccgggcgag gctgcccggg agccctcgat ggccttcatt tcacccaagc ccgcttcttg    360

ctttccccgg cgcttcccct cttttcctgg ttaacagctt atgggcgggg agctcggcaa    420

aactcagact aaaaacagaa aaagagaaaa gaaaggacaa attcgataca cccgcgtcgg    480

tcctccagag tttgtgaagg ggtgtaaaca tgtcggagtc tggggagatg agtgaatttg    540

gctacatcat ggaattgata gctaaaggca aggcttcagc aatgggcctg cagcaaaccc    600

atgagcattc ccggttgact tctaaaggtg gagaggcccg ctgtcccttt gaaatctctg    660

aggttggaaa gcagtctctc ccaagaagaa cttaggacaa ttcctctctc tgttttgtgg    720

gggttggagg gggagagttg gtctggagta ggctcctaac catttcaacg taagcttatt    780

tcctaccact ctcctcaggc tcaaatcctg ccccgccccg cagccccagc actagcccat    840

ttaagacccc tgttttgtgt gtgattatac aggatttgaa cactgaatat taaccatgga    900

atagca                                                               906


<210>  318
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  318

Met Ser Glu Ser Gly Glu Met Ser Glu Phe Gly Tyr Ile Met Glu Leu 
1               5                   10                  15      


Ile Ala Lys Gly Lys Ala Ser Ala Met Gly Leu Gln Gln Thr His Glu 
            20                  25                  30          


His Ser Arg Leu Thr Ser Lys Gly Gly Glu Ala Arg Cys Pro Phe Glu 
        35                  40                  45              


Ile Ser Glu Val Gly Lys Gln Ser Leu Pro Arg Arg Thr 
    50                  55                  60      


<210>  319
<211>  4456
<212>  DNA
<213>  Homosapiens

<400>  319
gatggggctt ttttccagat cttcgcgccg agagccgggg acggccaacc tgccggcatg     60

cgataaaggc cggggaatgt ctagctgggg ccgcgctgag ccgagtgcgg acccgctttg    120

tgtgcgcgtt tgtttgtctc cgctgcggtc cgaaccgctg ccgcgacccc cgaggaggcg    180

gggcctccgc gcgcccggct ccgcctggtg agggtttcac ggcctctgct gccgccgccg    240

ccgccctcgt ttgttccgtt agatcgcgca gccccgaccg ctgcacccgg atcctagcaa    300

gccgggcgag gctgcccggg agccctcgat ggccttcatt tcacccaagc ccgcttcttg    360

ctttccccgg cgcttcccct cttttcctgg ttaacagctt atgggcgggg agctcggcaa    420

aactcagact aaaaacagaa aaagagaaaa gaaaggacaa attcgataca cccgcgtcgg    480

tcctccagag tttgtgaagg ggtgtaaaca tgtcggagtc tggggagatg agtgaatttg    540

gctacatcat ggaattgata gctaaaggca aggttaccat taagaatatc gaaagggagc    600

tcatttgccc agcatgcaag gagctgttta cccacccatt gattctccct tgccaacata    660

gtatctgtca taaatgtgta aaagaactcc tgctgactct cgatgattca ttcaacgatg    720

tgggatcaga caactccaat caaagcagtc ctcgacttcg gctcccctcc cctagtatgg    780

ataaaattga ccgaattaac agaccaggct ggaagcgcaa ttcattgacc ccgaggacaa    840

ctgttttccc ttgccctggc tgtgagcatg atgtggatct tggagaacga ggaatcaatg    900

gtctgtttcg aaacttcact ttggaaacta ttgtggaaag atatcgtcaa gcagctaggg    960

cagccacagc cattatgtgt gacctttgta aaccaccacc tcaagaatcc acaaaaagct   1020

gcatggactg tagtgcaagt tactgcaatg aatgcttcaa aattcatcac ccttggggta   1080

ctataaaagc tcaacatgag tatgttggtc caactactaa cttcagaccc aagattttaa   1140

tgtgcccaga acatgaaaca gagagaataa acatgtactg tgaattatgt aggaggccag   1200

tttgccatct gtgtaagttg ggtggtaatc atgccaacca ccgtgtaacc actatgagca   1260

gtgcctacaa aaccttaaag gaaaagcttt caaaggatat tgattacctt attggtaagg   1320

aaagccaggt gaagagtcaa atatctgaac taaacttgtt aatgaaagaa acagagtgta   1380

atggagagag ggctaaagaa gaagcaatta cacattttga aaagctcttt gaagttctgg   1440

aagagaggaa atcatctgtt ttgaaagcaa ttgactcctc taagaaacta agattagaca   1500

aatttcagac tcaaatggaa gagtaccagg gacttctaga gaacaatgga cttgtgggat   1560

atgctcaaga agtgctaaag gagacagatc agtcttgctt tgtgcagaca gcaaagcagc   1620

tccacctcag aatacagaaa gccacagaat ctttgaagag ctttagacct gcagctcaga   1680

cttcttttga agactatgtt gttaatacct ctaaacaaac agaacttctt ggagaattat   1740

cctttttctc tagtggcata gacgtgccag agatcaatga ggaacagagc aaagtttata   1800

acaatgcctt gataaattgg caccatccag aaaaggataa agctgatagc tatgttcttg   1860

aatatcggaa aatcaataga gatgatgaaa tgtcatggaa tgagatagaa gtgtgtggaa   1920

caagtaaaat aattcaagac ttggaaaaca gtagtaccta tgctttcaga gtaagagctt   1980

acaagggttc aatctgtagt ccttgcagca gagaattgat tcttcatact cctccagctc   2040

cagttttcag cttcctcttt gatgaaaaat gtggctataa taatgaacac ctcctgctga   2100

acttgaagag agaccgtgta gagagtagag ctggatttaa tcttctgctt gctgcagaac   2160

gcatccaagt gggttattac acaagcttag actacatcat tggagatact ggcattacaa   2220

aaggaaaaca cttctgggcc ttccgtgtgg aaccatattc atacctggta aaagtgggag   2280

ttgcttctag cgataaacta caagaatggc tccgttctcc ccgggatgca gttagtccaa   2340

gatatgagca agacagtggg catgacagtg gaagtgagga tgcctgtttt gattcttcac   2400

aaccatttac cttagttact ataggcatgc agaaattttt tatacccaag tcacctactt   2460

cttctaatga acctgaaaat agagttctcc ctatgccaac aagtattggg attttccttg   2520

actgtgataa aggcaaagta gatttctatg atatggatca gatgaaatgc ctttatgaac   2580

gccaagtgga ctgttcacat acactgtatc cagcatttgc attaatgggc agtggaggaa   2640

ttcagcttga agaacccatc acagcaaaat atctggaata ccaagaggac atgtagttga   2700

aacatctgat gtgactcagg ataaaaactg taaacaaagc aatgccttag cgttaacctt   2760

cgtaactaat tacatatcgc tgagtgttct gtcaccccac ttgtgtttga gtatgattct   2820

tcttgaaata cagaaaatct aaacagcctt gtgtcttcat gtcgttgttc tgcctttcac   2880

aaatgatgaa agtgaagatg ttctttccaa gttaatactg aagtggttaa ctttgcaact   2940

ggactgtctt ttactttatg tacaggatat ctaatttatt tctgtcagct ggtgttgctg   3000

acactttcct tatggtgggg gggatacaaa agtatttatt atgattctct tctgtttgac   3060

ttttcatttt tatatcatgt ttatgtccta agagaagata ttttttaaat gccttatgga   3120

taggaattag tactaagcaa tgtgtcttgc atttgttttc aataggaaaa caaagttcta   3180

gataggttaa aagaaaaaca ccataaaagt ggtagtatat ttaagtggaa aattatgtat   3240

tttaaagtgt gtaactatta aaaatatatt gcctggaaaa ggaatactac tgttttgttt   3300

tgttaagacc acaaactgta ttgctaagga cattttaaga gtctgcttag ccataacact   3360

catttaacag catgggtagt aagcatggtt tcttgcagaa aacacaaagt tctcagctaa   3420

cacattaaac ttctcacttt atatactttt tttcagagaa atttatcttt agtttttctt   3480

attctgtgaa aatatttgtt cttatgtcaa agaattattt ttcagatata ttggtaaaga   3540

tggactgata ttaaaagtca tatttattct tttaccccct tactgtgttt tgtgattttc   3600

atttttggcc caattattac atatcaggtt ttcctgattt atatttacat gtttgaaaag   3660

ttcattatat attttagtag cgttacatat attataaatt tttgtaacat ttaaatgttc   3720

acttatgtgg cattttctgt ttctcattgg taataagcat ttctaatata agcaagtaaa   3780

aatacaaatt taattactta gaaatgataa ctaagatcac aatgactgtg taccctttaa   3840

aatatctttt aatttgagga attacattct atctaaattg tgtgtctgtt tttgaaaggt   3900

gttgctttca agtaggtggt ttttatttaa agtacttatt tttttgaggt taaaatattc   3960

agaaactact tttatgcatt gtagcagtaa tcatttatgg aatgcttttg acatgtttta   4020

acagggtaac caaaactttt aggcctgttt tttttggttg tccttgttgt tatattttta   4080

atggaaatct gttactcagg ctggtagcat taaattagct ttttaccctc aactcaagta   4140

gcaaatatca tggagaactt cagtgtttag caggctgtta atttcccatc tatgaatagc   4200

actttatgat gtaggctaaa ctaagcaaat aatgcagcgt tatgtggatc attatgcaat   4260

aaagctgcta aagtcacatt tgtggttgat actcaagcct tgtacaagca catatgatgt   4320

agacattttt aaatgtgaag ctttaacagg aataggatag ctgtttcaaa ccttgtgcaa   4380

ttgtaaataa attgtttagc tgtgtttctt tcatttttaa taaaaaatta aaaagaaaaa   4440

aaaaaaaaaa aaaaaa                                                   4456


<210>  320
<211>  728
<212>  PRT
<213>  Homosapiens

<400>  320

Met Ser Glu Ser Gly Glu Met Ser Glu Phe Gly Tyr Ile Met Glu Leu 
1               5                   10                  15      


Ile Ala Lys Gly Lys Val Thr Ile Lys Asn Ile Glu Arg Glu Leu Ile 
            20                  25                  30          


Cys Pro Ala Cys Lys Glu Leu Phe Thr His Pro Leu Ile Leu Pro Cys 
        35                  40                  45              


Gln His Ser Ile Cys His Lys Cys Val Lys Glu Leu Leu Leu Thr Leu 
    50                  55                  60                  


Asp Asp Ser Phe Asn Asp Val Gly Ser Asp Asn Ser Asn Gln Ser Ser 
65                  70                  75                  80  


Pro Arg Leu Arg Leu Pro Ser Pro Ser Met Asp Lys Ile Asp Arg Ile 
                85                  90                  95      


Asn Arg Pro Gly Trp Lys Arg Asn Ser Leu Thr Pro Arg Thr Thr Val 
            100                 105                 110         


Phe Pro Cys Pro Gly Cys Glu His Asp Val Asp Leu Gly Glu Arg Gly 
        115                 120                 125             


Ile Asn Gly Leu Phe Arg Asn Phe Thr Leu Glu Thr Ile Val Glu Arg 
    130                 135                 140                 


Tyr Arg Gln Ala Ala Arg Ala Ala Thr Ala Ile Met Cys Asp Leu Cys 
145                 150                 155                 160 


Lys Pro Pro Pro Gln Glu Ser Thr Lys Ser Cys Met Asp Cys Ser Ala 
                165                 170                 175     


Ser Tyr Cys Asn Glu Cys Phe Lys Ile His His Pro Trp Gly Thr Ile 
            180                 185                 190         


Lys Ala Gln His Glu Tyr Val Gly Pro Thr Thr Asn Phe Arg Pro Lys 
        195                 200                 205             


Ile Leu Met Cys Pro Glu His Glu Thr Glu Arg Ile Asn Met Tyr Cys 
    210                 215                 220                 


Glu Leu Cys Arg Arg Pro Val Cys His Leu Cys Lys Leu Gly Gly Asn 
225                 230                 235                 240 


His Ala Asn His Arg Val Thr Thr Met Ser Ser Ala Tyr Lys Thr Leu 
                245                 250                 255     


Lys Glu Lys Leu Ser Lys Asp Ile Asp Tyr Leu Ile Gly Lys Glu Ser 
            260                 265                 270         


Gln Val Lys Ser Gln Ile Ser Glu Leu Asn Leu Leu Met Lys Glu Thr 
        275                 280                 285             


Glu Cys Asn Gly Glu Arg Ala Lys Glu Glu Ala Ile Thr His Phe Glu 
    290                 295                 300                 


Lys Leu Phe Glu Val Leu Glu Glu Arg Lys Ser Ser Val Leu Lys Ala 
305                 310                 315                 320 


Ile Asp Ser Ser Lys Lys Leu Arg Leu Asp Lys Phe Gln Thr Gln Met 
                325                 330                 335     


Glu Glu Tyr Gln Gly Leu Leu Glu Asn Asn Gly Leu Val Gly Tyr Ala 
            340                 345                 350         


Gln Glu Val Leu Lys Glu Thr Asp Gln Ser Cys Phe Val Gln Thr Ala 
        355                 360                 365             


Lys Gln Leu His Leu Arg Ile Gln Lys Ala Thr Glu Ser Leu Lys Ser 
    370                 375                 380                 


Phe Arg Pro Ala Ala Gln Thr Ser Phe Glu Asp Tyr Val Val Asn Thr 
385                 390                 395                 400 


Ser Lys Gln Thr Glu Leu Leu Gly Glu Leu Ser Phe Phe Ser Ser Gly 
                405                 410                 415     


Ile Asp Val Pro Glu Ile Asn Glu Glu Gln Ser Lys Val Tyr Asn Asn 
            420                 425                 430         


Ala Leu Ile Asn Trp His His Pro Glu Lys Asp Lys Ala Asp Ser Tyr 
        435                 440                 445             


Val Leu Glu Tyr Arg Lys Ile Asn Arg Asp Asp Glu Met Ser Trp Asn 
    450                 455                 460                 


Glu Ile Glu Val Cys Gly Thr Ser Lys Ile Ile Gln Asp Leu Glu Asn 
465                 470                 475                 480 


Ser Ser Thr Tyr Ala Phe Arg Val Arg Ala Tyr Lys Gly Ser Ile Cys 
                485                 490                 495     


Ser Pro Cys Ser Arg Glu Leu Ile Leu His Thr Pro Pro Ala Pro Val 
            500                 505                 510         


Phe Ser Phe Leu Phe Asp Glu Lys Cys Gly Tyr Asn Asn Glu His Leu 
        515                 520                 525             


Leu Leu Asn Leu Lys Arg Asp Arg Val Glu Ser Arg Ala Gly Phe Asn 
    530                 535                 540                 


Leu Leu Leu Ala Ala Glu Arg Ile Gln Val Gly Tyr Tyr Thr Ser Leu 
545                 550                 555                 560 


Asp Tyr Ile Ile Gly Asp Thr Gly Ile Thr Lys Gly Lys His Phe Trp 
                565                 570                 575     


Ala Phe Arg Val Glu Pro Tyr Ser Tyr Leu Val Lys Val Gly Val Ala 
            580                 585                 590         


Ser Ser Asp Lys Leu Gln Glu Trp Leu Arg Ser Pro Arg Asp Ala Val 
        595                 600                 605             


Ser Pro Arg Tyr Glu Gln Asp Ser Gly His Asp Ser Gly Ser Glu Asp 
    610                 615                 620                 


Ala Cys Phe Asp Ser Ser Gln Pro Phe Thr Leu Val Thr Ile Gly Met 
625                 630                 635                 640 


Gln Lys Phe Phe Ile Pro Lys Ser Pro Thr Ser Ser Asn Glu Pro Glu 
                645                 650                 655     


Asn Arg Val Leu Pro Met Pro Thr Ser Ile Gly Ile Phe Leu Asp Cys 
            660                 665                 670         


Asp Lys Gly Lys Val Asp Phe Tyr Asp Met Asp Gln Met Lys Cys Leu 
        675                 680                 685             


Tyr Glu Arg Gln Val Asp Cys Ser His Thr Leu Tyr Pro Ala Phe Ala 
    690                 695                 700                 


Leu Met Gly Ser Gly Gly Ile Gln Leu Glu Glu Pro Ile Thr Ala Lys 
705                 710                 715                 720 


Tyr Leu Glu Tyr Gln Glu Asp Met 
                725             


<210>  321
<211>  1659
<212>  DNA
<213>  Homosapiens

<400>  321
gcatggtggc cactgaggat gagaggctag cagggagcgg tgagggagag cggctggatt     60

tcttacggga tcggcacgtg cgatttttcc agcgctgcct ccaggttttg ccggagcgct    120

attcttcact cgagacaagc aggttgacaa ttgcattttt tgcactctcc gggctggata    180

tgttggattc cttagatgtg gtgaacaaag atgatataat agagtggatt tattccctgc    240

aggtccttcc cacagaagac agatcaaatc taaatcgctg tggtttccga ggctcttcat    300

acctgggtat tccgttcaat ccatcaaagg ctcctggaac agctcatcct tatgatagtg    360

gccacattgc aatgacctac actggcctct catgcttagt tattcttgga gacgacttaa    420

gccgagtaaa taaagaagct tgcttagcgg gcttgagagc ccttcagctg gaagatggga    480

gtttttgtgc agtacctgaa ggcagtgaaa atgacatgcg atttgtgtac tgtgcttcct    540

gtatttgcta tatgctcaac aactggtcag gcatggatat gaaaaaagcc atcacctata    600

ttagaaggag tatgtcctat gacaatggac tggcacaggg agctggactt gaatctcatg    660

gaggatcaac tttttgtggc attgcctcac tatgtctgat gggtaaacta gaagaagttt    720

tttcagaaaa agaattgaac aggataaaga ggtggtgtat aatgaggcaa caaaatggtt    780

atcatggaag acctaataag cctgtagaca cctgttattc tttttgggtg ggagcaactc    840

tgaagcttct aaaaattttc caatacacta actttgagaa aaatagaaat tacatcttat    900

caactcaaga tcgccttgta gggggatttg ccaagtggcc agacagtcat ccagatgctt    960

tgcatgcata ctttgggatc tgtggcctgt cactaatgga ggaaagtgga atttgtaaag   1020

ttcatcctgc tctgaatgta agcacacgga cttctgaacg ccttctagat ctccatcaaa   1080

gctggaaaac caaggactct aaacaatgct cagagaatgt acatatctcc acatgactga   1140

ttttagattg ggagggtggg ggggatttgt agcataactg tagctcaagt ttaaaagcca   1200

tgtataacca agtgtgctct ttttttaaaa ggtagagtct tacaatcaaa tctcctgctg   1260

atttcacttt gggatatggt cttgagccag taatctttat actgggtttc aagaaaatct   1320

ttgttgaagt ttgaaccaca actttgtcgt ggttcttaaa tgtttatact gtatttctaa   1380

gaagttgttt gaggcaaatt aactgtatgt gtgtaggtta tctttttaaa aactcttcag   1440

tgcaaattgt atcttattat aaaatggaca caaattttca agtttacact tcatatagca   1500

ttgataatct tcaggtgaac acttagtgat catttaaaaa gctcactgct gatcgtagaa   1560

aatttgcttt aattaattaa gtatctggga ttattctttg aaaacagatg accataattt   1620

tttttaaaga agagtgactt attttgtctt attcttaag                          1659


<210>  322
<211>  377
<212>  PRT
<213>  Homosapiens

<400>  322

Met Val Ala Thr Glu Asp Glu Arg Leu Ala Gly Ser Gly Glu Gly Glu 
1               5                   10                  15      


Arg Leu Asp Phe Leu Arg Asp Arg His Val Arg Phe Phe Gln Arg Cys 
            20                  25                  30          


Leu Gln Val Leu Pro Glu Arg Tyr Ser Ser Leu Glu Thr Ser Arg Leu 
        35                  40                  45              


Thr Ile Ala Phe Phe Ala Leu Ser Gly Leu Asp Met Leu Asp Ser Leu 
    50                  55                  60                  


Asp Val Val Asn Lys Asp Asp Ile Ile Glu Trp Ile Tyr Ser Leu Gln 
65                  70                  75                  80  


Val Leu Pro Thr Glu Asp Arg Ser Asn Leu Asn Arg Cys Gly Phe Arg 
                85                  90                  95      


Gly Ser Ser Tyr Leu Gly Ile Pro Phe Asn Pro Ser Lys Ala Pro Gly 
            100                 105                 110         


Thr Ala His Pro Tyr Asp Ser Gly His Ile Ala Met Thr Tyr Thr Gly 
        115                 120                 125             


Leu Ser Cys Leu Val Ile Leu Gly Asp Asp Leu Ser Arg Val Asn Lys 
    130                 135                 140                 


Glu Ala Cys Leu Ala Gly Leu Arg Ala Leu Gln Leu Glu Asp Gly Ser 
145                 150                 155                 160 


Phe Cys Ala Val Pro Glu Gly Ser Glu Asn Asp Met Arg Phe Val Tyr 
                165                 170                 175     


Cys Ala Ser Cys Ile Cys Tyr Met Leu Asn Asn Trp Ser Gly Met Asp 
            180                 185                 190         


Met Lys Lys Ala Ile Thr Tyr Ile Arg Arg Ser Met Ser Tyr Asp Asn 
        195                 200                 205             


Gly Leu Ala Gln Gly Ala Gly Leu Glu Ser His Gly Gly Ser Thr Phe 
    210                 215                 220                 


Cys Gly Ile Ala Ser Leu Cys Leu Met Gly Lys Leu Glu Glu Val Phe 
225                 230                 235                 240 


Ser Glu Lys Glu Leu Asn Arg Ile Lys Arg Trp Cys Ile Met Arg Gln 
                245                 250                 255     


Gln Asn Gly Tyr His Gly Arg Pro Asn Lys Pro Val Asp Thr Cys Tyr 
            260                 265                 270         


Ser Phe Trp Val Gly Ala Thr Leu Lys Leu Leu Lys Ile Phe Gln Tyr 
        275                 280                 285             


Thr Asn Phe Glu Lys Asn Arg Asn Tyr Ile Leu Ser Thr Gln Asp Arg 
    290                 295                 300                 


Leu Val Gly Gly Phe Ala Lys Trp Pro Asp Ser His Pro Asp Ala Leu 
305                 310                 315                 320 


His Ala Tyr Phe Gly Ile Cys Gly Leu Ser Leu Met Glu Glu Ser Gly 
                325                 330                 335     


Ile Cys Lys Val His Pro Ala Leu Asn Val Ser Thr Arg Thr Ser Glu 
            340                 345                 350         


Arg Leu Leu Asp Leu His Gln Ser Trp Lys Thr Lys Asp Ser Lys Gln 
        355                 360                 365             


Cys Ser Glu Asn Val His Ile Ser Thr 
    370                 375         


<210>  323
<211>  2101
<212>  DNA
<213>  Homosapiens

<400>  323
gtttaacagc ttttgcagag ccgcctccat gtggtttcgg agtcgaggaa gacctgggtg     60

ggaacccggc tctgccgctt cctagccgcg tgataagaac atatgctgtc ggcgactcac    120

tttcttctct aaaaattggg aatagtaaca tgcacctccc gagctttgga ctaacgttat    180

gtctggggag cccctggcac agtgcttgat tggaggggga ctctgtgctc agtaattggt    240

ggcagctctg ttactgtacc ggcgctggga acacaaggag aaagacaata tgggatggtc    300

ggaggcagag gtgtttccag tgatcggctt aggaccgctt tctaggtggt gaggacaaga    360

gtgatggctg ttttagtact tcaggtggaa ttcgtccttt tcatcttcag aactggaagc    420

agaaagttaa tcagactaag aaagcagaat ttgtacgcac agcagaaaaa tttaaaaatc    480

aagtaattaa catggaaaaa gataaacaca gtcatttcta caaccaaaaa agtgacttca    540

gaattgagca tagtatgcta gaagaattgg aaaataaatt gattcacagc aggaaaacag    600

aaagagcaaa aatccagcaa caattggcca aaatacataa taatgtaaag aaacttcagc    660

atcaattaaa agatgtgaag cctacacctg attttgttga gaagctcaga gaaatgatgg    720

aagaaattga aaatgcaatt aacactttta aagaagagca gaggttgata tatgaagagc    780

taattaaaga agagaagaca actaataatg agttgagtgc catatcaaga aaaattgaca    840

catgggcttt gggtaattca gaaacagaga aagctttcag agcaatctca agcaaagttc    900

ctgtagacaa agtaacacca agtactcttc cagaagaggt actagatttt gaaaaattcc    960

ttcagcaaac aggagggcga caaggtgcct gggatgatta tgatcaccag aactttgtaa   1020

aggtgagaaa caaacataaa gggaagccaa catttatgga agaagttcta gaacaccttc   1080

ctggaaaaac acaagatgaa gttcaacagc atgaaaaatg gtatcaaaag tttctggctc   1140

tagaagaaag aaaaaaagag tcaattcaga tttggaaaac taaaaagcag caaaaaaggg   1200

aggaaatttt caagttaaag gaaaaggcag acaacacacc tgtgcttttt cataataaac   1260

aagaggataa tcaaaagcaa aaagaggaac aaagaaagaa acagaaattg gcagttgaag   1320

cttggaagaa acagaaaagt atagaaatgt caatgaaatg tgcttcccag ttaaaagaag   1380

aagaagagaa agagaaaaaa catcagaaag aacgccagcg ccagtttaag ttaaaattac   1440

tactagaaag ttatacccag cagaagaaag aacaggaaga atttttgagg cttgaaaagg   1500

agataaggga aaatgcagaa aaggcagaaa aaaggaaaaa tgctgctgat ggaatttcca   1560

gatttcaaga aagagattta cataaacttg aactgaaaat tctagataga caggcaaagg   1620

aagatgaaaa gtcacaaaaa caaagaagac tggcaaaatt aaaagaaaag gttgaaaaca   1680

atgttagtag agatccctct aggctttaca aacccaccaa aggttgggaa gaacgaacca   1740

aaaagatagg accaacaggc tctgggccac ttctacatat cccacatagg gctattccaa   1800

cctggagaca aggaatacag agaagagtat gagataatca aattgctact cagttgataa   1860

gaatgttaac atactaagtt ataccaggga gagagtgact aaccacattc tttaaatatc   1920

aatagcttag tcagattgat tattgtgcta tattgtgaat tgagaggtat taagtttcat   1980

gaggctttgt cattagtatt cctgcttcta ccaagaaggt atttaatata tgtgttggcc   2040

tattattgat gtaaaagtta tttaaataaa aaaaaaaaaa aaaaagaaaa aaaaaaaaaa   2100

a                                                                   2101


<210>  324
<211>  446
<212>  PRT
<213>  Homosapiens

<400>  324

Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys Ser Asp Phe 
1               5                   10                  15      


Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys Leu Ile His 
            20                  25                  30          


Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu Ala Lys Ile 
        35                  40                  45              


His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp Val Lys Pro 
    50                  55                  60                  


Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu Glu Ile Glu 
65                  70                  75                  80  


Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile Tyr Glu Glu 
                85                  90                  95      


Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr Glu Lys Ala 
        115                 120                 125             


Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val Thr Pro Ser 
    130                 135                 140                 


Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu Gln Gln Thr 
145                 150                 155                 160 


Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln Asn Phe Val 
                165                 170                 175     


Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met Glu Glu Val 
            180                 185                 190         


Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln Gln His Glu 
        195                 200                 205             


Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys Lys Glu Ser 
    210                 215                 220                 


Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu Glu Ile Phe 
225                 230                 235                 240 


Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe His Asn Lys 
                245                 250                 255     


Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys Lys Gln Lys 
            260                 265                 270         


Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu Met Ser Met 
        275                 280                 285             


Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu Lys Lys His 
    290                 295                 300                 


Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu Leu Glu Ser 
305                 310                 315                 320 


Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg Leu Glu Lys 
                325                 330                 335     


Glu Ile Arg Glu Asn Ala Glu Lys Ala Glu Lys Arg Lys Asn Ala Ala 
            340                 345                 350         


Asp Gly Ile Ser Arg Phe Gln Glu Arg Asp Leu His Lys Leu Glu Leu 
        355                 360                 365             


Lys Ile Leu Asp Arg Gln Ala Lys Glu Asp Glu Lys Ser Gln Lys Gln 
    370                 375                 380                 


Arg Arg Leu Ala Lys Leu Lys Glu Lys Val Glu Asn Asn Val Ser Arg 
385                 390                 395                 400 


Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu Glu Arg Thr 
                405                 410                 415     


Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His Ile Pro His 
            420                 425                 430         


Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg Val 
        435                 440                 445     


<210>  325
<211>  2626
<212>  DNA
<213>  Homosapiens

<400>  325
gaattcctcg acactgttgg cctactggat ttatttgaaa ggaatgagga tcctgcactc     60

ttcctccctc agtaagtaaa tgccagtccc taggaagaga gaaccaaaat gtctaccgga    120

ccagatgtca aggctacagt gggggacatt tccagtgatg gcaatttaaa cgtggctcaa    180

gaggaatgct ccaggaaagg tttttgttca gtccgacatg ggctggccct catcttgcag    240

ctctgtaatt tttcaattta cacccaacaa atgaacttga gcattgccat tccagctatg    300

gtgaacaaca cagccccacc tagccagccc aatgcctcca cagaacggcc ctccactgac    360

tcccagggct actggaatga aactctaaaa gaatttaaag caatggcccc tgcatatgac    420

tggagtcctg aaatccaggg aatcatcctc agctccctca actatggctc attcttggct    480

ccaatcccca gtggctatgt ggctggaata tttggagcca agtatgtggt tggtgctggc    540

ttgtttattt cctcattcct gaccctcttc attccactgg cagctaatgc gggagtggcc    600

ttgctcattg tcctccggat tgtacaaggc atagcccagg ttatggtatt aactggtcag    660

tattcaattt gggtcaaatg ggctccccca ctggaaagga gtcaactcac caccattgct    720

ggatcagggt caatgctggg gtccttcatt gttctacttg ctggtggtct cctctgccag    780

accataggat ggccttacgt cttctatatc tttggaggaa ttggctgtgc ttgttgtcct    840

ctctggtttc ctctcattta tgatgatcct gtgaatcatc cctttatcag tgctggtgag    900

aagagataca ttgtgtgttc attggctcag caggactgtt caccaggctg gtctcttccc    960

attagggcta tgatcaaatc cttaccactc tgggccattt tagtctctta tttctgtgaa   1020

tactggcttt tttataccat tatggcgtac acaccaacgt acatcagctc ggtacttcaa   1080

gccaacctca gagatagtgg gatcctgtct gccttgccgt ttgttgttgg atgtatctgc   1140

attatccttg gaggtctact ggcagacttt cttctctcca gaaaaatcct cagactcatc   1200

accatcagga aactcttcac tgccattggg gttctcttcc catccgtgat cctcgtgtcc   1260

ctgccctggg tcagatccag ccacagcatg accatgacct tcttggtgct gtcttctgcc   1320

atcagcagct tctgtgaatc aggagccctt gttaacttct tggatattgc tcctcggtac   1380

actggctttc tcaaaggact attgcaagtc tttgcacaca tagctggagc catctctcct   1440

actgctgctg gatttttcat cagtcaggat tcagagtttg gttggagaaa tgtcttcttg   1500

ctttcagctg ctgttaacat atcgggcctg gttttctacc tcatctttgg ccgagcagat   1560

gtgcaggact gggctaagga gcagacattc acccacctct gagcaaaccg agagatgtgc   1620

tagatcctgg tgcttagttc atcattgttt tccctcacag acatttctct ttcatgcctg   1680

cttgactgat aagccattag ctagaccctg actatgtaac gctaaagatt ttaccatgcc   1740

tggaaatttt acaggggaag aaaacacgct agttatttaa ctgcaagcta ctaaaagcat   1800

aggtgtgttg agatttctgt gttctccact cttccactgt tatcctagta aaagcatcag   1860

gggctgggga caatttcttt ccaaagcaaa agaggaagcc agaccttggg accgagaact   1920

gagaatcaca agggagttgc gcccaacatg cagaacatga atcctctgag ctgtcctcaa   1980

aagaaagccc caaacaacag aaagcatagt gttttccatt gttggtgaaa aatgtcaagg   2040

aggaaagaac aataatgatt ccatcatgat aagaggaatg aacgtgtctg caactaatgg   2100

gagcaagata gtacacttta actctttcag acaacttgca ttctgtggat gccagctttg   2160

gaatcagagc cgcctctgga atacctgtgc ttccagagtt agcttttgga cagttacctt   2220

ctttctggcc atcttgactt ctgccccaca tctgcttttt ggctttgtgc agatctttaa   2280

catgttagtg aacagacatt gcccagtgtc tcttctagcc cctccaacag ttcttcatgt   2340

agcactgctt ttggacagtg acccatgata tctgccttcg tttgcccctc tgactgttgg   2400

aatcccacgc accattcagt aggattcaat tcaatgtgga accattcaac attcacctca   2460

ttaacctaaa atgtctccca aagatgtatg taagacacac actgccctaa cctcacttca   2520

aatgtctgga gaaatgtgtg tagtgctttt gttaaagccc ctatatgggc agcatggagg   2580

atcataagat agcaaaacca tttcaacact aaatgaatat taatgt                  2626


<210>  326
<211>  497
<212>  PRT
<213>  Homosapiens

<400>  326

Met Ser Thr Gly Pro Asp Val Lys Ala Thr Val Gly Asp Ile Ser Ser 
1               5                   10                  15      


Asp Gly Asn Leu Asn Val Ala Gln Glu Glu Cys Ser Arg Lys Gly Phe 
            20                  25                  30          


Cys Ser Val Arg His Gly Leu Ala Leu Ile Leu Gln Leu Cys Asn Phe 
        35                  40                  45              


Ser Ile Tyr Thr Gln Gln Met Asn Leu Ser Ile Ala Ile Pro Ala Met 
    50                  55                  60                  


Val Asn Asn Thr Ala Pro Pro Ser Gln Pro Asn Ala Ser Thr Glu Arg 
65                  70                  75                  80  


Pro Ser Thr Asp Ser Gln Gly Tyr Trp Asn Glu Thr Leu Lys Glu Phe 
                85                  90                  95      


Lys Ala Met Ala Pro Ala Tyr Asp Trp Ser Pro Glu Ile Gln Gly Ile 
            100                 105                 110         


Ile Leu Ser Ser Leu Asn Tyr Gly Ser Phe Leu Ala Pro Ile Pro Ser 
        115                 120                 125             


Gly Tyr Val Ala Gly Ile Phe Gly Ala Lys Tyr Val Val Gly Ala Gly 
    130                 135                 140                 


Leu Phe Ile Ser Ser Phe Leu Thr Leu Phe Ile Pro Leu Ala Ala Asn 
145                 150                 155                 160 


Ala Gly Val Ala Leu Leu Ile Val Leu Arg Ile Val Gln Gly Ile Ala 
                165                 170                 175     


Gln Val Met Val Leu Thr Gly Gln Tyr Ser Ile Trp Val Lys Trp Ala 
            180                 185                 190         


Pro Pro Leu Glu Arg Ser Gln Leu Thr Thr Ile Ala Gly Ser Gly Ser 
        195                 200                 205             


Met Leu Gly Ser Phe Ile Val Leu Leu Ala Gly Gly Leu Leu Cys Gln 
    210                 215                 220                 


Thr Ile Gly Trp Pro Tyr Val Phe Tyr Ile Phe Gly Gly Ile Gly Cys 
225                 230                 235                 240 


Ala Cys Cys Pro Leu Trp Phe Pro Leu Ile Tyr Asp Asp Pro Val Asn 
                245                 250                 255     


His Pro Phe Ile Ser Ala Gly Glu Lys Arg Tyr Ile Val Cys Ser Leu 
            260                 265                 270         


Ala Gln Gln Asp Cys Ser Pro Gly Trp Ser Leu Pro Ile Arg Ala Met 
        275                 280                 285             


Ile Lys Ser Leu Pro Leu Trp Ala Ile Leu Val Ser Tyr Phe Cys Glu 
    290                 295                 300                 


Tyr Trp Leu Phe Tyr Thr Ile Met Ala Tyr Thr Pro Thr Tyr Ile Ser 
305                 310                 315                 320 


Ser Val Leu Gln Ala Asn Leu Arg Asp Ser Gly Ile Leu Ser Ala Leu 
                325                 330                 335     


Pro Phe Val Val Gly Cys Ile Cys Ile Ile Leu Gly Gly Leu Leu Ala 
            340                 345                 350         


Asp Phe Leu Leu Ser Arg Lys Ile Leu Arg Leu Ile Thr Ile Arg Lys 
        355                 360                 365             


Leu Phe Thr Ala Ile Gly Val Leu Phe Pro Ser Val Ile Leu Val Ser 
    370                 375                 380                 


Leu Pro Trp Val Arg Ser Ser His Ser Met Thr Met Thr Phe Leu Val 
385                 390                 395                 400 


Leu Ser Ser Ala Ile Ser Ser Phe Cys Glu Ser Gly Ala Leu Val Asn 
                405                 410                 415     


Phe Leu Asp Ile Ala Pro Arg Tyr Thr Gly Phe Leu Lys Gly Leu Leu 
            420                 425                 430         


Gln Val Phe Ala His Ile Ala Gly Ala Ile Ser Pro Thr Ala Ala Gly 
        435                 440                 445             


Phe Phe Ile Ser Gln Asp Ser Glu Phe Gly Trp Arg Asn Val Phe Leu 
    450                 455                 460                 


Leu Ser Ala Ala Val Asn Ile Ser Gly Leu Val Phe Tyr Leu Ile Phe 
465                 470                 475                 480 


Gly Arg Ala Asp Val Gln Asp Trp Ala Lys Glu Gln Thr Phe Thr His 
                485                 490                 495     


Leu 
    


<210>  327
<211>  1549
<212>  DNA
<213>  Homosapiens

<400>  327
cttcagccgt gtatgcaaat ggataaccgg ttgcctccca aaaaagttcc aggtttctgt     60

tcctttcgct atggattgtc tttccttgtg cactgttgta atgttataat aacagcacag    120

cgtgcgtgcc tgaacctcac aatggtagtc atggtgaata gcacagatcc acatggtttg    180

cccaacacct ccacaaagaa gctcctggat aatataaaga accctatgta taattggagc    240

ccagatatcc agggaatcat cttgagttcc acctcctatg gtgtcatcat catccaagtt    300

cctgttggat acttctctgg aatatattct acaaagaaaa tgattggctt tgcattatgc    360

ctcagctctg tgttaagcct gctcatccca ccagcagctg gaattggagt agcttgggtc    420

gttgtatgtc gagcagttca gggagcagcc caggggatag ttgcaacagc ccagtttgaa    480

atatatgtca aatgggctcc tcccctggaa cgaggccgac ttacttctat gagtacatca    540

gggtttttgc tgggaccctt tattgtccta cttgtgactg gagttatctg tgaatctctg    600

ggctggccca tggtcttcta tatttttggt gcttgtggct gtgccgtatg tcttctctgg    660

ttcgttctgt tttatgatga ccccaaagac cacccatgta taagcatcag tgaaaaggaa    720

tacatcacat cctccctggt ccagcaggtc agttcaagta gacaatctct gcctatcaag    780

gctatactta agtcgcttcc agtctgggct atttccattg gtagttttac gtttttctgg    840

tcacataaca tcatgacact atacactcca atgtttatca actccatgct tcatgttaat    900

ataaaagaga atgggttctt gtcttccctt ccctatttgt ttgcctggat ctgtggtaac    960

ctagcaggtc agttatcaga cttcttcctg accaggaata ttctcagcgt aattgctgtc   1020

cggaaactct tcacagcagc aggatttctc cttcctgcaa tctttggtgt ctgcctgcct   1080

tacctgagtt ccaccttcta cagcattgtc attttcctaa tacttgctgg tgcaacaggc   1140

agcttttgct tgggtggagt gtttataaat ggcttggata ttgctcccag atattttgga   1200

tttattaaag catgttcaac tttaactgga atgataggag gactaattgc ttccactttg   1260

actggattga tccttaagca ggatccggaa tccgcctggt ttaaaacctt catcctgatg   1320

gcagccatta atgtgactgg cctaattttc taccttatag ttgctacagc agaaattcag   1380

gactgggcta aagaaaaaca acacacacgt ctctgaagtg tgaaacagag cacttgcaga   1440

gcctgggaca acctccttat tgaagggaag agggaccagc acatgaggct gaggctgagg   1500

ggcagtcacc agcaccagga agaaggtggt aggaggagtc ctaggggct               1549


<210>  328
<211>  467
<212>  PRT
<213>  Homosapiens

<400>  328

Met Gln Met Asp Asn Arg Leu Pro Pro Lys Lys Val Pro Gly Phe Cys 
1               5                   10                  15      


Ser Phe Arg Tyr Gly Leu Ser Phe Leu Val His Cys Cys Asn Val Ile 
            20                  25                  30          


Ile Thr Ala Gln Arg Ala Cys Leu Asn Leu Thr Met Val Val Met Val 
        35                  40                  45              


Asn Ser Thr Asp Pro His Gly Leu Pro Asn Thr Ser Thr Lys Lys Leu 
    50                  55                  60                  


Leu Asp Asn Ile Lys Asn Pro Met Tyr Asn Trp Ser Pro Asp Ile Gln 
65                  70                  75                  80  


Gly Ile Ile Leu Ser Ser Thr Ser Tyr Gly Val Ile Ile Ile Gln Val 
                85                  90                  95      


Pro Val Gly Tyr Phe Ser Gly Ile Tyr Ser Thr Lys Lys Met Ile Gly 
            100                 105                 110         


Phe Ala Leu Cys Leu Ser Ser Val Leu Ser Leu Leu Ile Pro Pro Ala 
        115                 120                 125             


Ala Gly Ile Gly Val Ala Trp Val Val Val Cys Arg Ala Val Gln Gly 
    130                 135                 140                 


Ala Ala Gln Gly Ile Val Ala Thr Ala Gln Phe Glu Ile Tyr Val Lys 
145                 150                 155                 160 


Trp Ala Pro Pro Leu Glu Arg Gly Arg Leu Thr Ser Met Ser Thr Ser 
                165                 170                 175     


Gly Phe Leu Leu Gly Pro Phe Ile Val Leu Leu Val Thr Gly Val Ile 
            180                 185                 190         


Cys Glu Ser Leu Gly Trp Pro Met Val Phe Tyr Ile Phe Gly Ala Cys 
        195                 200                 205             


Gly Cys Ala Val Cys Leu Leu Trp Phe Val Leu Phe Tyr Asp Asp Pro 
    210                 215                 220                 


Lys Asp His Pro Cys Ile Ser Ile Ser Glu Lys Glu Tyr Ile Thr Ser 
225                 230                 235                 240 


Ser Leu Val Gln Gln Val Ser Ser Ser Arg Gln Ser Leu Pro Ile Lys 
                245                 250                 255     


Ala Ile Leu Lys Ser Leu Pro Val Trp Ala Ile Ser Ile Gly Ser Phe 
            260                 265                 270         


Thr Phe Phe Trp Ser His Asn Ile Met Thr Leu Tyr Thr Pro Met Phe 
        275                 280                 285             


Ile Asn Ser Met Leu His Val Asn Ile Lys Glu Asn Gly Phe Leu Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Leu Phe Ala Trp Ile Cys Gly Asn Leu Ala Gly Gln 
305                 310                 315                 320 


Leu Ser Asp Phe Phe Leu Thr Arg Asn Ile Leu Ser Val Ile Ala Val 
                325                 330                 335     


Arg Lys Leu Phe Thr Ala Ala Gly Phe Leu Leu Pro Ala Ile Phe Gly 
            340                 345                 350         


Val Cys Leu Pro Tyr Leu Ser Ser Thr Phe Tyr Ser Ile Val Ile Phe 
        355                 360                 365             


Leu Ile Leu Ala Gly Ala Thr Gly Ser Phe Cys Leu Gly Gly Val Phe 
    370                 375                 380                 


Ile Asn Gly Leu Asp Ile Ala Pro Arg Tyr Phe Gly Phe Ile Lys Ala 
385                 390                 395                 400 


Cys Ser Thr Leu Thr Gly Met Ile Gly Gly Leu Ile Ala Ser Thr Leu 
                405                 410                 415     


Thr Gly Leu Ile Leu Lys Gln Asp Pro Glu Ser Ala Trp Phe Lys Thr 
            420                 425                 430         


Phe Ile Leu Met Ala Ala Ile Asn Val Thr Gly Leu Ile Phe Tyr Leu 
        435                 440                 445             


Ile Val Ala Thr Ala Glu Ile Gln Asp Trp Ala Lys Glu Lys Gln His 
    450                 455                 460                 


Thr Arg Leu 
465         


<210>  329
<211>  1795
<212>  DNA
<213>  Homosapiens

<400>  329
acgcgtccgc ccacgcgtcc gcccacgcgt ccggtcgggg ccagagcgca ggtgtacctg     60

gcggccgtgc tggagcacct gaccgccgag atcctggagc tggctggcaa cccggcccgc    120

gacaagaaga cccgcatcat cctgcgccac ctgtagctgg ccattcgcaa cggcgaggag    180

cttaacaagc tgctgggcga agtcaccatc gcgcagggcg gtgtcctgcc caacattcag    240

ggcgtgcttc tgccccagaa gaccaagagc caccacaagg ccaagggtga aaaccattca    300

ctaggagagg agaaacacaa tggccaccaa gacagagttg agtcccacag caagggagag    360

caagaacgca caagatatgc aagtggatga gacactgatc cccaggaaag gtccaagttt    420

atgttctgct cgctatggaa tagccctcgt cttacatttc tgcaatttca caacgatagc    480

acaaaatgtc atcatgaaca tcaccatggt agccatggtc aacagcacaa gccctcaatc    540

ccagctcaat gattcctctg aggtgctgcc tgttgactca tttggtggcc taagtaaagc    600

cccaaagagt cttcctgcaa agtcctcaat acttgggggt cagtttgcaa tttgggaaaa    660

gtggggccct ccacaagaac gaagcagact ctgcagcatt gctttatcag gaatgttact    720

gggatgcttt actgccatcc tcataggtgg cttcattagt gaaacccttg ggtggccctt    780

tgtcttctat atctttggag gtgttggctg tgtctgctgc cttctctggt ttgttgtgat    840

ttatgatgac cccttttcct atccatggat aagcacctca gaaaaagaat acatcatatc    900

ctccttgaaa caacaggtcg ggtcttctaa gcagcctctt cccatcaaag ctatgctcag    960

atctctaccc atttggtcca tatgtttagg ctgtttcagc catcaatggt tagttagcac   1020

aatggttgta tacataccaa cttacatcag ctctgtgtac catgttaaca tcagagacaa   1080

tggacttcta tctgcccttc cttttattgt tgcctgggtc ataggcatgg tgggaggcta   1140

tctggcagat ttccttctaa ccaaaaagtt tagactcatc actgtgagga aaattgccac   1200

aattttagga agtctcccct cttcagcact cattgtgtct ctgccttacc tcaattccgg   1260

ctatatcaca gcaactgcct tgctgacgct ctcttgcgga ttaagcacat tgtgtcagtc   1320

agggatttat atcaatgtct tagatattgc tccaaggtat tccagttttc tcatgggagc   1380

atcaagagga ttttcgagca tagcacctgt cattgtaccc actgtcagcg gatttcttct   1440

tagtcaggac cctgagtttg ggtggaggaa tgtcttcttc ttgctgtttg ccgttaacct   1500

gttaggacta ctcttctacc tcatatttgg agaagcagat gtccaagaat gggctaaaga   1560

gagaaaactc actcgtttat gaagttatcc caccttggat ggaaaagtca ttaggcaccg   1620

tattgcataa aatagaaggc ttccgtgatg aaaataccag tgaaaagatt tttttttcct   1680

gtggctcttt tcaattatga gatcagttca ttattttatt cagacttttt tttgagagaa   1740

atgtaagatg aataaaaatt caaataaaat gataactaag aaaaaaaaaa aaaaa        1795


<210>  330
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  330

Met Gln Val Asp Glu Thr Leu Ile Pro Arg Lys Gly Pro Ser Leu Cys 
1               5                   10                  15      


Ser Ala Arg Tyr Gly Ile Ala Leu Val Leu His Phe Cys Asn Phe Thr 
            20                  25                  30          


Thr Ile Ala Gln Asn Val Ile Met Asn Ile Thr Met Val Ala Met Val 
        35                  40                  45              


Asn Ser Thr Ser Pro Gln Ser Gln Leu Asn Asp Ser Ser Glu Val Leu 
    50                  55                  60                  


Pro Val Asp Ser Phe Gly Gly Leu Ser Lys Ala Pro Lys Ser Leu Pro 
65                  70                  75                  80  


Ala Lys Ser Ser Ile Leu Gly Gly Gln Phe Ala Ile Trp Glu Lys Trp 
                85                  90                  95      


Gly Pro Pro Gln Glu Arg Ser Arg Leu Cys Ser Ile Ala Leu Ser Gly 
            100                 105                 110         


Met Leu Leu Gly Cys Phe Thr Ala Ile Leu Ile Gly Gly Phe Ile Ser 
        115                 120                 125             


Glu Thr Leu Gly Trp Pro Phe Val Phe Tyr Ile Phe Gly Gly Val Gly 
    130                 135                 140                 


Cys Val Cys Cys Leu Leu Trp Phe Val Val Ile Tyr Asp Asp Pro Phe 
145                 150                 155                 160 


Ser Tyr Pro Trp Ile Ser Thr Ser Glu Lys Glu Tyr Ile Ile Ser Ser 
                165                 170                 175     


Leu Lys Gln Gln Val Gly Ser Ser Lys Gln Pro Leu Pro Ile Lys Ala 
            180                 185                 190         


Met Leu Arg Ser Leu Pro Ile Trp Ser Ile Cys Leu Gly Cys Phe Ser 
        195                 200                 205             


His Gln Trp Leu Val Ser Thr Met Val Val Tyr Ile Pro Thr Tyr Ile 
    210                 215                 220                 


Ser Ser Val Tyr His Val Asn Ile Arg Asp Asn Gly Leu Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Phe Ile Val Ala Trp Val Ile Gly Met Val Gly Gly Tyr Leu 
                245                 250                 255     


Ala Asp Phe Leu Leu Thr Lys Lys Phe Arg Leu Ile Thr Val Arg Lys 
            260                 265                 270         


Ile Ala Thr Ile Leu Gly Ser Leu Pro Ser Ser Ala Leu Ile Val Ser 
        275                 280                 285             


Leu Pro Tyr Leu Asn Ser Gly Tyr Ile Thr Ala Thr Ala Leu Leu Thr 
    290                 295                 300                 


Leu Ser Cys Gly Leu Ser Thr Leu Cys Gln Ser Gly Ile Tyr Ile Asn 
305                 310                 315                 320 


Val Leu Asp Ile Ala Pro Arg Tyr Ser Ser Phe Leu Met Gly Ala Ser 
                325                 330                 335     


Arg Gly Phe Ser Ser Ile Ala Pro Val Ile Val Pro Thr Val Ser Gly 
            340                 345                 350         


Phe Leu Leu Ser Gln Asp Pro Glu Phe Gly Trp Arg Asn Val Phe Phe 
        355                 360                 365             


Leu Leu Phe Ala Val Asn Leu Leu Gly Leu Leu Phe Tyr Leu Ile Phe 
    370                 375                 380                 


Gly Glu Ala Asp Val Gln Glu Trp Ala Lys Glu Arg Lys Leu Thr Arg 
385                 390                 395                 400 


Leu 
    


<210>  331
<211>  2281
<212>  DNA
<213>  Homosapiens

<400>  331
ggacagaaaa ctccctcctt ttccaagtta gccttatagt ctagggctta aaatactggt     60

ttaatggtga aggtaagtgc ttttcttctt tttgggtaga aggattatta ctaacttacc    120

aaaggtccat taaggggagg gaacagtttt aggagaagtc agagaaaaga cattaacagc    180

aacataagga tctccatctg gtaatattgc ctaattccaa aatgaagaga ctctctgaaa    240

aagataactg attcaatgaa gaccctaggg caaggcttga gaagccactg gtaccaatgg    300

acactgtgga caatggtcat ttctccaagg acgctataaa agactgtcgt agtaaaagag    360

attcagggca cagggaaact ccaccacaaa gcgtggtacc atttcccaca gaagctaaat    420

ggacgggaag cctgccacca ggaaaggtcc agatttctgt tcattacgct atgggctggc    480

tcttatcatg cacttctcaa acttcaccat gataacgcag cgtgtgagtc tgagcattgc    540

gatcatcgcc atggtgaaca ccactcagca gcaaggtcta tctaatgcct ccactgaggg    600

gcctgttgca gatgccttca ataactccag catatccatc aaggaatttg atacaaaggc    660

ctctgtgtat caatggagcc cagaaactca gggtatcatc tttagctcca tcaactatgg    720

gataatactg actctgatcc caagtggata tttagcaggg atatttggag caaaaaaaat    780

gcttggtgct ggtttgctga tctcttccct tctcaccctc tttacaccac tggctgctga    840

cttcggagtg attttggtca tcatggttcg gacagtccag ggcatggccc agggaatggc    900

atggacaggt cagtttacta tttgggcaaa gtgggctcct ccacttgaac gaagcaagct    960

caccaccatt gcaggatcag ggtcagcatt tggatccttc atcatcctct gtgtgggggg   1020

actaatctca caggccttga gctggccttt tatcttctac atctttggta gcactggctg   1080

tgtctgctgt ctcctatggt tcacagtgat ttatgatgac cccatgcatc acccgtgcat   1140

aagtgttagg gaaaaggagc acatcctgtc ctcactggct caacagccca gttctcctgg   1200

acgagctgtc cccataaagg cgatggtcac atgcctacca ctttgggcca ttttcctggg   1260

ttttttcagc catttctggt tatgcaccat catcctaaca tacctaccaa cgtatatcag   1320

tactctgctc catgttaaca tcagagatag tggagttctg tcctccctgc cttttattgc   1380

tgctgcaagc tgtacaattt taggaggtca gctggcagat ttccttttgt ccaggaatct   1440

tctcagattg atcactgtgc gaaagctctt ttcatctctt gatatgcaag tttcctcatg   1500

ggaatctcaa ggggatttgg gctcatcgca ggaatcatct cttccactgc cactggattc   1560

ctcatcagtc aggattttga gtctggttgg aggaatgtct ttttcctgtc tgctgcagtc   1620

aacatgtttg gcctggtctt ttacctcacg tttggacaag cagaacttca agactgggcc   1680

aaagagagga cccttacccg cctctgagga cataaagtta caaacttaaa tgtggtactg   1740

agcatgaact ttttaaacat tttttacttc tctccatatt cctgaccata gactcagcag   1800

ttcttaactc tggctgtgtg ttagtcttcc ctggggagcc tttataagac actgatactt   1860

gggacccact ccagagattc tgaatgaatt ggtctggggt ggaacccaga tactactaat   1920

ttttagatac tccttagagg tttctagcat gcgcccgggg ttgacaacag ctggacaaac   1980

ttgaaaagtc aattcatgtg gcctttgaat tttcctcatt ggaaagtact aaataaataa   2040

aaattcatgt gaaaatgatc actgataaat atcttcatgg tggggcaggt tattggatgc   2100

agagaagatc tgctcggaat tgtagccata tgttacagat ctcagcaccg atcagaactg   2160

taaagctata atccccagaa ttaaagtttt tattattttt tatacattgt aaaacataga   2220

cgtttattta tgtgattaaa ttctattaaa atttacatgc taaaataaaa aaaaaaaaaa   2280

a                                                                   2281


<210>  332
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  332

Met Asp Gly Lys Pro Ala Thr Arg Lys Gly Pro Asp Phe Cys Ser Leu 
1               5                   10                  15      


Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn Phe Thr Met Ile 
            20                  25                  30          


Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala Met Val Asn Thr 
        35                  40                  45              


Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu Gly Pro Val Ala 
    50                  55                  60                  


Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu Phe Asp Thr Lys 
65                  70                  75                  80  


Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly Ile Ile Phe Ser 
                85                  90                  95      


Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro Ser Gly Tyr Leu 
            100                 105                 110         


Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala Gly Leu Leu Ile 
        115                 120                 125             


Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala Asp Phe Gly Val 
    130                 135                 140                 


Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met Ala Gln Gly Met 
145                 150                 155                 160 


Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp Ala Pro Pro Leu 
                165                 170                 175     


Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly Ser Ala Phe Gly 
            180                 185                 190         


Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser Gln Ala Leu Ser 
        195                 200                 205             


Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly Cys Val Cys Cys 
    210                 215                 220                 


Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met His His Pro Cys 
225                 230                 235                 240 


Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser Leu Ala Gln Gln 
                245                 250                 255     


Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala Met Val Thr Cys 
            260                 265                 270         


Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser His Phe Trp Leu 
        275                 280                 285             


Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile Ser Thr Leu Leu 
    290                 295                 300                 


His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser Leu Pro Phe Ile 
305                 310                 315                 320 


Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu Ala Asp Phe Leu 
                325                 330                 335     


Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg Lys Leu Phe Ser 
            340                 345                 350         


Ser Leu Asp Met Gln Val Ser Ser Trp Glu Ser Gln Gly Asp Leu Gly 
        355                 360                 365             


Ser Ser Gln Glu Ser Ser Leu Pro Leu Pro Leu Asp Ser Ser Ser Val 
    370                 375                 380                 


Arg Ile Leu Ser Leu Val Gly Gly Met Ser Phe Ser Cys Leu Leu Gln 
385                 390                 395                 400 


Ser Thr Cys Leu Ala Trp Ser Phe Thr Ser Arg Leu Asp Lys Gln Asn 
                405                 410                 415     


Phe Lys Thr Gly Pro Lys Arg Gly Pro Leu Pro Ala Ser Glu Asp Ile 
            420                 425                 430         


Lys Leu Gln Thr 
        435     


<210>  333
<211>  3286
<212>  DNA
<213>  Homosapiens

<400>  333
tagcagcgaa tatactttac accaaatctc agaagattca gaacttagat gagtggggcc     60

caggacagga accctggagc cttggaagga ggggagcccc atctccccag aagagcagtg    120

accccagcag agaggggcct ggtgtatcac tggaggaaat agcctgccaa ggaatacacg    180

tcttcagaag aaattctgtg tggcttcaag agactgatca aattgtgaga ggaaaacagc    240

ctacccggtc ctcttttctt caatacaaaa tgagataata ggggttggaa ggaaaacctt    300

caagacctat ggaagtcagt tgcagccagc tcatcacata gaggtgcagg tgaggtgtat    360

tttcatcacg gtggaaaatt ctggctgctt catctccatc tctagagcca atattggagc    420

ttttcaataa aagctatggc ctcaaccacc agcaccaaga agatgatgga ggaagccacc    480

tgctccatct gcctgagcct gatgacgaac ccagtaagca tcaactgtgg acacagctac    540

tgccacttgt gtataacaga cttctttaaa aacccaagcc aaaagcaact gaggcaggag    600

acattctgct gtccccagtg tcgggctcca tttcatatgg atagcctccg acccaacaag    660

cagctgggaa gcctcattga agccctcaaa gagacggatc aagaaatgtc atgtgaggaa    720

cacggagagc agttccacct gttctgcgaa gacgaggggc agctcatctg ctggcgctgt    780

gagcgggcac cacagcacaa agggcacacc acagctcttg ttgaagacgt atgccagggc    840

tacaaggaaa agctccagaa agctgtgaca aaactgaagc aacttgaaga cagatgtacg    900

gagcagaagc tgtccacagc aatgcgaata actaaatgga aagagaaggt acagattcag    960

agacaaaaaa tccggtctga ctttaagaat ctccagtgtt tcctacatga ggaagagaag   1020

tcttatctct ggaggctgga gaaagaagaa caacagactc tgagtagact gagggactat   1080

gaggctggtc tggggctgaa gagcaatgaa ctcaagagcc acatcctgga actggaggaa   1140

aaatgtcagg gctcagccca gaaattgctg cagaatgtga atgacacttt gagcaggagt   1200

tgggctgtga agctggaaac atcagaggct gtctccttgg aacttcatac tatgtgcaat   1260

gtttccaagc tttacttcga tgtgaagaaa atgttaagga gtcatcaagt tagtgtgact   1320

ctggatccag atacagctca tcacgaacta attctctctg aggatcggag acaagtgact   1380

cgtggataca cccaggagaa tcaggacaca tcttccagga gatttactgc cttcccctgt   1440

gtcttgggtt gtgaaggctt cacctcagga agacgttact ttgaagtgga tgttggcgaa   1500

ggaaccggat gggatttagg agtttgtatg gaaaatgtgc agaggggcac tggcatgaag   1560

caagagcctc agtctggatt ctggaccctc aggctgtgca aaaagaaagg ctatgtagca   1620

cttacttctc ccccaacttc ccttcatctg catgagcagc ccctgcttgt gggaattttt   1680

ctggactatg aggccggagt tgtatccttt tataacggga atactggctg ccacatcttt   1740

actttcccga aggcttcctt ctctgatact ctccggccct atttccaggt ttatcaatat   1800

tctcctttgt ttctgcctcc cccaggtgac taaggaaaag agcagaagct ccttggttta   1860

accagcacag agaaaataat ataaatccca taagggcaga cgtttggtct gttttcttcg   1920

ctgtcatttc cttagtagtt agactagtgc tgagatttta gtggatatat aattgattta   1980

tgttgaatat atggacttag caactaaaaa taccacagat ggttaacctg gactggggca   2040

aagcaagata atagtgatga tcgtatgttg ctgtctccat ccgtctttaa tgggtcaggg   2100

ctttgatttc caagggtctt caggtgatga gtaggggtac ccacaagtca gaaggtctgc   2160

gttctcctag tttgtttgct gccatttgaa ctcatgtagg gaatgaaaga aagctgcaat   2220

tatccgccaa ctgcatttaa aacaaaacaa aacagaaaaa tcaaaataac attgactctt   2280

ccaaccactg acatgttgtt taataatcta agcggcagtc ctggaggcta ccagacttac   2340

tgagttctac ctgagaaaca gccaagcaaa gtgtgagaga agggttaaga ctggcttaca   2400

atgagatgct tcaaatgaaa agggaattat gagtaaaatt gaactttgat gggggattca   2460

gttctggaaa agaatttggt attttccagt ctgctaggac caattacctt gaaatatttt   2520

aaaatctcag taaatagtta ttgctgaaat ggctgttggc agttcttatt atgattcaga   2580

gaagagcaaa tagaccttaa cttcattttg aaaaagacca aattaccata cccgagtgag   2640

taatgacagg actacaacta aaacataaac aacattaatg atgaccataa aaagtcacaa   2700

aattgctaaa tgttataatt tagagttgac ataaaaattg atggccaggc atggtggctc   2760

acgcctgtaa tcccagaact atgtgaggct gaggcaggtg gatcacttga ggtcaggagt   2820

tcaacaccag cctggccaac atggtgaaac cctgtctcta ctaaaaatac aaaaattagc   2880

cgggcatggt ggtaggggcc tgtaacccag ctactcgtga ggccaaggca ggagaattgc   2940

ttgagcctgc agcagctgca gtaagccaag atcatgctgt gcctcaagga aaaaaaaaat   3000

taatgtttac tgatatttgt tgaagtccta caacatcacc tctgagaata ggagaaatga   3060

agcaacagtt gtgtctagat gtcagaggca tggctgggcc tccatctctg cctaagggag   3120

atataaaaga gttcaaacta ttgcccatgt tccccagggt cagaagttct aattatgatg   3180

atagaggctg ggttgtaagt agtaagtgaa gggtagcaga atatgccatc tttggcataa   3240

gaagtatttt gagttgaaga caattgagaa aaaaaaaaaa aaaaaa                  3286


<210>  334
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  334

Met Ala Ser Thr Thr Ser Thr Lys Lys Met Met Glu Glu Ala Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Ser Leu Met Thr Asn Pro Val Ser Ile Asn Cys Gly 
            20                  25                  30          


His Ser Tyr Cys His Leu Cys Ile Thr Asp Phe Phe Lys Asn Pro Ser 
        35                  40                  45              


Gln Lys Gln Leu Arg Gln Glu Thr Phe Cys Cys Pro Gln Cys Arg Ala 
    50                  55                  60                  


Pro Phe His Met Asp Ser Leu Arg Pro Asn Lys Gln Leu Gly Ser Leu 
65                  70                  75                  80  


Ile Glu Ala Leu Lys Glu Thr Asp Gln Glu Met Ser Cys Glu Glu His 
                85                  90                  95      


Gly Glu Gln Phe His Leu Phe Cys Glu Asp Glu Gly Gln Leu Ile Cys 
            100                 105                 110         


Trp Arg Cys Glu Arg Ala Pro Gln His Lys Gly His Thr Thr Ala Leu 
        115                 120                 125             


Val Glu Asp Val Cys Gln Gly Tyr Lys Glu Lys Leu Gln Lys Ala Val 
    130                 135                 140                 


Thr Lys Leu Lys Gln Leu Glu Asp Arg Cys Thr Glu Gln Lys Leu Ser 
145                 150                 155                 160 


Thr Ala Met Arg Ile Thr Lys Trp Lys Glu Lys Val Gln Ile Gln Arg 
                165                 170                 175     


Gln Lys Ile Arg Ser Asp Phe Lys Asn Leu Gln Cys Phe Leu His Glu 
            180                 185                 190         


Glu Glu Lys Ser Tyr Leu Trp Arg Leu Glu Lys Glu Glu Gln Gln Thr 
        195                 200                 205             


Leu Ser Arg Leu Arg Asp Tyr Glu Ala Gly Leu Gly Leu Lys Ser Asn 
    210                 215                 220                 


Glu Leu Lys Ser His Ile Leu Glu Leu Glu Glu Lys Cys Gln Gly Ser 
225                 230                 235                 240 


Ala Gln Lys Leu Leu Gln Asn Val Asn Asp Thr Leu Ser Arg Ser Trp 
                245                 250                 255     


Ala Val Lys Leu Glu Thr Ser Glu Ala Val Ser Leu Glu Leu His Thr 
            260                 265                 270         


Met Cys Asn Val Ser Lys Leu Tyr Phe Asp Val Lys Lys Met Leu Arg 
        275                 280                 285             


Ser His Gln Val Ser Val Thr Leu Asp Pro Asp Thr Ala His His Glu 
    290                 295                 300                 


Leu Ile Leu Ser Glu Asp Arg Arg Gln Val Thr Arg Gly Tyr Thr Gln 
305                 310                 315                 320 


Glu Asn Gln Asp Thr Ser Ser Arg Arg Phe Thr Ala Phe Pro Cys Val 
                325                 330                 335     


Leu Gly Cys Glu Gly Phe Thr Ser Gly Arg Arg Tyr Phe Glu Val Asp 
            340                 345                 350         


Val Gly Glu Gly Thr Gly Trp Asp Leu Gly Val Cys Met Glu Asn Val 
        355                 360                 365             


Gln Arg Gly Thr Gly Met Lys Gln Glu Pro Gln Ser Gly Phe Trp Thr 
    370                 375                 380                 


Leu Arg Leu Cys Lys Lys Lys Gly Tyr Val Ala Leu Thr Ser Pro Pro 
385                 390                 395                 400 


Thr Ser Leu His Leu His Glu Gln Pro Leu Leu Val Gly Ile Phe Leu 
                405                 410                 415     


Asp Tyr Glu Ala Gly Val Val Ser Phe Tyr Asn Gly Asn Thr Gly Cys 
            420                 425                 430         


His Ile Phe Thr Phe Pro Lys Ala Ser Phe Ser Asp Thr Leu Arg Pro 
        435                 440                 445             


Tyr Phe Gln Val Tyr Gln Tyr Ser Pro Leu Phe Leu Pro Pro Pro Gly 
    450                 455                 460                 


Asp 
465 


<210>  335
<211>  757
<212>  DNA
<213>  Homosapiens

<400>  335
cgcatcctgc ttcgtcaggt ttataccact ttatttggtg tgctgtgtta gtcaccatgt     60

ctgaaacagt gcctcccgcc cccgccgctt ctgctgctcc tgagaaacct ttagctggca    120

agaaggcaaa gaaacctgct aaggctgcag cagcctccaa gaaaaaaccc gctggccctt    180

ccgtgtcaga gctgatcgtg caggctgctt cctcctctaa ggagcgtggt ggtgtgtcgt    240

tggcagctct taaaaaggcg ctggcggccg caggctacga cgtggagaag aacaacagcc    300

gcattaagct gggcattaag agcctggtaa gcaagggaac gttggtgcag acaaagggta    360

ccggagcctc gggttccttc aagctcaaca agaaggcgtc ctccgtggaa accaagcccg    420

gcgcctcaaa ggtggctaca aaaactaagg caacgggtgc atctaaaaag ctcaaaaagg    480

ccacgggggc tagcaaaaag agcgtcaaga ctccgaaaaa ggctaaaaag cctgcggcaa    540

caaggaaatc ctccaagaat ccaaaaaaac ccaaaactgt aaagcccaag aaagtagcta    600

aaagccctgc taaagctaag gctgtaaaac ccaaggcggc caaggctagg gtgacgaagc    660

caaagactgc caaacccaag aaagcggcac ccaagaaaaa gtaaattcag ttagaagttt    720

cttctagtaa cccaacggct cttttaagag ccaccta                             757


<210>  336
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  336

Met Ser Glu Thr Val Pro Pro Ala Pro Ala Ala Ser Ala Ala Pro Glu 
1               5                   10                  15      


Lys Pro Leu Ala Gly Lys Lys Ala Lys Lys Pro Ala Lys Ala Ala Ala 
            20                  25                  30          


Ala Ser Lys Lys Lys Pro Ala Gly Pro Ser Val Ser Glu Leu Ile Val 
        35                  40                  45              


Gln Ala Ala Ser Ser Ser Lys Glu Arg Gly Gly Val Ser Leu Ala Ala 
    50                  55                  60                  


Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn 
65                  70                  75                  80  


Ser Arg Ile Lys Leu Gly Ile Lys Ser Leu Val Ser Lys Gly Thr Leu 
                85                  90                  95      


Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys 
            100                 105                 110         


Lys Ala Ser Ser Val Glu Thr Lys Pro Gly Ala Ser Lys Val Ala Thr 
        115                 120                 125             


Lys Thr Lys Ala Thr Gly Ala Ser Lys Lys Leu Lys Lys Ala Thr Gly 
    130                 135                 140                 


Ala Ser Lys Lys Ser Val Lys Thr Pro Lys Lys Ala Lys Lys Pro Ala 
145                 150                 155                 160 


Ala Thr Arg Lys Ser Ser Lys Asn Pro Lys Lys Pro Lys Thr Val Lys 
                165                 170                 175     


Pro Lys Lys Val Ala Lys Ser Pro Ala Lys Ala Lys Ala Val Lys Pro 
            180                 185                 190         


Lys Ala Ala Lys Ala Arg Val Thr Lys Pro Lys Thr Ala Lys Pro Lys 
        195                 200                 205             


Lys Ala Ala Pro Lys Lys Lys 
    210                 215 


<210>  337
<211>  469
<212>  DNA
<213>  Homosapiens

<400>  337
atggctcgca ctaagcaaac tgctcggaag tctactggtg gcaaggcgcc acgcaaacag     60

ttggccacta aggcagcccg caaaagcgct ccggccaccg gcggcgtgaa aaagccccac    120

cgctaccggc cgggcaccgt ggctctgcgc gagatccgcc gttatcagaa gtccactgaa    180

ctgcttattc gtaaactacc tttccagcgc ctggtgcgcg agattgcgca ggactttaaa    240

acagacctgc gtttccagag ctccgctgtg atggctctgc aggaggcgtg cgaggcctac    300

ttggtagggc tatttgagga cactaacctg tgcgccatcc acgccaagcg cgtcactatc    360

atgcccaagg acatccagct cgcccgccgc atccgcggag agagggcgtg attactgtgg    420

tctctctgac ggtccaagca aaggctcttt tcagagccac caccttttc                469


<210>  338
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  338

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  339
<211>  372
<212>  DNA
<213>  Homosapiens

<400>  339
atgtctggac gtggtaaggg cgggaagggt ttgggtaagg ggggtgccaa gcgccaccgc     60

aaggtgttgc gtgacaacat ccagggcatc accaagccgg ccatccggcg tctggcccgg    120

cgtggcggtg tgaagcggat ctctggtctg atctacgagg agactcgcgg ggtgctcaag    180

gtgtttttgg agaacgtgat ccgtgacgct gtcacctata cggagcacgc caagcgcaag    240

acagtcactg ccatggacgt ggtctacgcg cttaagcgcc agggacgcac cctttatggc    300

tttggcggtt aaggttgctg atttctccac agcttgcatt tctgaaccaa aggccctttt    360

cagggccgcc ca                                                        372


<210>  340
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  340

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  341
<211>  357
<212>  DNA
<213>  Homosapiens

<400>  341
atgtctggtc gcggcaaagg cggtaaaggt ttgggtaagg gaggtgccaa gcgtcaccga     60

aaagtgctgc gggataacat ccaaggcatc accaaaccgg ccattcggcg ccttgctagg    120

cgtggtgggg ttaagcgaat ttccggtttg atttatgagg agactcgtgg cgttctcaag    180

gtgtttctgg agaacgtgat ccgggacgcc gtgacctaca cggagcacgc caagcgcaag    240

actgtcactg ccatggatgt ggtttacgcg ctcaagcgtc aaggacgcac tctgtacggc    300

ttcggcggtt aatcttttcg tcagttttct tccaatggcc cttttcaggg ccgccca       357


<210>  342
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  342

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  343
<211>  472
<212>  DNA
<213>  Homosapiens

<400>  343
atggctcgta ctaaacagac agctcggaaa tccaccggcg gtaaagcgcc acgcaagcag     60

ctggctacca aggctgctcg caagagcgcg ccggctaccg gcggcgtgaa aaagcctcac    120

cgttaccgcc cgggcactgt ggctctgcgc gagatccgcc gctaccaaaa gtcgaccgag    180

ttgctgattc ggaagctgcc gttccagcgc ctggtgcgag aaatcgccca agacttcaag    240

accgatcttc gcttccagag ctctgcggtg atggcgctgc aggaggcttg tgaggcctac    300

ttggtagggc tctttgagga cacaaacctt tgcgccatcc atgctaagcg agtgactatt    360

atgcccaaag acatccagct cgctcgccgc attcgcggag aaagagcgta aatgtaaagt    420

cactttttca tcagtcttaa aacccaaagg ctcttttcag agccacccac tt            472


<210>  344
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  344

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  345
<211>  477
<212>  DNA
<213>  Homosapiens

<400>  345
atgtctggtc gcggcaaaca aggcggtaaa gctcgcgcca aggctaagac tcggtcttct     60

cgtgcaggtt tgcagtttcc tgtgggccga gtgcaccgcc tgctccgcaa aggcaactac    120

tccgagcgcg tcggggctgg cgcgccggtg tatctcgcgg cggtgcttga gtacctgacc    180

gccgagatcc tggagctggc gggcaatgcg gcccgcgaca acaagaagac ccgcatcatc    240

ccgcgccacc tgcaattggc catccgcaat gacgaggagc ttaataaact cttggggcgt    300

gtgaccatcg cgcagggtgg cgttttgcct aatattcagg cggtgctgct gcctaagaaa    360

actgagagcc atcataaggc caagggaaag tgaagagtta acgcttcatg cactgctgtt    420

tttctgtcag cagacaaaat cagcctaaca gcaaaggctc ttttcagagc cacctac       477


<210>  346
<211>  130
<212>  PRT
<213>  Homosapiens

<400>  346

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ser Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Arg Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  347
<211>  431
<212>  DNA
<213>  Homosapiens

<400>  347
atgcctgaac cctctaagtc tgctccagcc cctaaaaagg gttctaagaa ggctatcact     60

aaggcgcaga agaaggatgg taagaagcgt aagcgcagcc gcaaggagag ctattctatc    120

tatgtgtaca aggttctgaa gcaggtccac cccgacaccg gcatctcatc caaggccatg    180

gggatcatga attccttcgt caacgacatc ttcgagcgca tcgcgggcga ggcttctcgc    240

ctggctcact acaataagcg ctcgaccatc acctccaggg agattcagac ggctgtgcgc    300

ctgctgctgc ctggggagct ggctaagcat gctgtgtccg agggcactaa ggcagttacc    360

aagtacacta gctctaaata agtgcttatg taagcacttc caaacccaaa ggctcttttc    420

agagccacct a                                                         431


<210>  348
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  348

Met Pro Glu Pro Ser Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Ile Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Ile Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  349
<211>  459
<212>  DNA
<213>  Homosapiens

<400>  349
atggctcgta cgaagcaaac agctcgcaag tctaccggcg gcaaagctcc gcgcaagcag     60

cttgctacta aagcagcccg taagagcgct ccggccaccg gtggcgtgaa gaaacctcat    120

cgctaccgcc cgggcaccgt ggccttgcgc gaaatccgtc gctaccagaa gtccaccgag    180

ctgctgatcc ggaagctgcc gttccagcgc ctggtgcgag aaatcgccca ggacttcaaa    240

accgacctgc gtttccagag ctctgcggtg atggcgctgc aggaggcttg tgaggcctac    300

ctggtgggac tcttcgaaga caccaatctg tgcgctattc acgctaaacg cgtcaccatc    360

atgcccaaag atatccagct ggcacgtcgc atccgtgggg aaagggcata agtctgcccg    420

tttcttcctc attgaaaagg ctcttttcag agccactca                           459


<210>  350
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  350

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  351
<211>  732
<212>  DNA
<213>  Homosapiens

<400>  351
catcggcgct ttgccacttg tacccgagtt tttgattctc aacatgtccg agactgctcc     60

tgccgctccc gctgccgcgc ctcctgcgga gaaggcccct gtaaagaaga aggcggccaa    120

aaaggctggg ggtacgcctc gtaaggcgtc tggtcccccg gtgtcagagc tcatcaccaa    180

ggctgtggcc gcctctaaag agcgtagcgg agtttctctg gctgctctga aaaaagcgtt    240

ggctgccgcc ggctatgatg tggagaaaaa caacagccgt atcaaacttg gtctcaagag    300

cctggtgagc aagggcactc tggtgcaaac gaaaggcacc ggtgcttctg gctcctttaa    360

actcaacaag aaggcagcct ccggggaagc caagcccaag gttaaaaagg cgggcggaac    420

caaacctaag aagccagttg gggcagccaa gaagcccaag aaggcggctg gcggcgcaac    480

tccgaagaag agcgctaaga aaacaccgaa gaaagcgaag aagccggccg cggccactgt    540

aaccaagaaa gtggctaaga gcccaaagaa ggccaaggtt gcgaagccca agaaagctgc    600

caaaagtgct gctaaggctg tgaagcccaa ggccgctaag cccaaggttg tcaagcctaa    660

gaaggcggcg cccaagaaga aataggcgaa cgcctacttc taaaacccaa aaggctcttt    720

tcagagccac ca                                                        732


<210>  352
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  352

Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Ala Glu 
1               5                   10                  15      


Lys Ala Pro Val Lys Lys Lys Ala Ala Lys Lys Ala Gly Gly Thr Pro 
            20                  25                  30          


Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val 
        35                  40                  45              


Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys 
    50                  55                  60                  


Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr 
                85                  90                  95      


Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala 
            100                 105                 110         


Ser Gly Glu Ala Lys Pro Lys Val Lys Lys Ala Gly Gly Thr Lys Pro 
        115                 120                 125             


Lys Lys Pro Val Gly Ala Ala Lys Lys Pro Lys Lys Ala Ala Gly Gly 
    130                 135                 140                 


Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Pro Ala Ala Ala Thr Val Thr Lys Lys Val Ala Lys Ser Pro Lys Lys 
                165                 170                 175     


Ala Lys Val Ala Lys Pro Lys Lys Ala Ala Lys Ser Ala Ala Lys Ala 
            180                 185                 190         


Val Lys Pro Lys Ala Ala Lys Pro Lys Val Val Lys Pro Lys Lys Ala 
        195                 200                 205             


Ala Pro Lys Lys Lys 
    210             


<210>  353
<211>  2727
<212>  DNA
<213>  Homosapiens

<400>  353
ggggacactg gatcacctag tgtttcacaa gcaggtacct tctgctgtag gagagagaga     60

actaaagttc tgaaagacct gttgcttttc accaggaagt tttactgggc atctcctgag    120

cctaggcaat agctgtaggg tgacttctgg agccatcccc gtttccccgc cccccaaaag    180

aagcggagat ttaacgggga cgtgcggcca gagctgggga aatgggcccg cgagccaggc    240

cggcgcttct cctcctgatg cttttgcaga ccgcggtcct gcaggggcgc ttgctgcgtt    300

cacactctct gcactacctc ttcatgggtg cctcagagca ggaccttggt ctttccttgt    360

ttgaagcttt gggctacgtg gatgaccagc tgttcgtgtt ctatgatcat gagagtcgcc    420

gtgtggagcc ccgaactcca tgggtttcca gtagaatttc aagccagatg tggctgcagc    480

tgagtcagag tctgaaaggg tgggatcaca tgttcactgt tgacttctgg actattatgg    540

aaaatcacaa ccacagcaag gagtcccaca ccctgcaggt catcctgggc tgtgaaatgc    600

aagaagacaa cagtaccgag ggctactgga agtacgggta tgatgggcag gaccaccttg    660

aattctgccc tgacacactg gattggagag cagcagaacc cagggcctgg cccaccaagc    720

tggagtggga aaggcacaag attcgggcca ggcagaacag ggcctacctg gagagggact    780

gccctgcaca gctgcagcag ttgctggagc tggggagagg tgttttggac caacaagtgc    840

ctcctttggt gaaggtgaca catcatgtga cctcttcagt gaccactcta cggtgtcggg    900

ccttgaacta ctacccccag aacatcacca tgaagtggct gaaggataag cagccaatgg    960

atgccaagga gttcgaacct aaagacgtat tgcccaatgg ggatgggacc taccagggct   1020

ggataacctt ggctgtaccc cctggggaag agcagagata tacgtgccag gtggagcacc   1080

caggcctgga tcagcccctc attgtgatct gggagccctc accgtctggc accctagtca   1140

ttggagtcat cagtggaatt gctgtttttg tcgtcatctt gttcattgga attttgttca   1200

taatattaag gaagaggcag ggttcaagag gagccatggg gcactacgtc ttagctgaac   1260

gtgagtgaca cgcagcctgc agactcactg tgggaaggag acaaaactag agactcaaag   1320

agggagtgca tttatgagct cttcatgttt caggagagag ttgaacctaa acatagaaat   1380

tgcctgacga actccttgat tttagccttc tctgttcatt tcctcaaaaa gatttcccca   1440

tttaggtttc tgagttcctg catgccggtg atccctagct gtgacctctc ccctggaact   1500

gtctctcatg aacctcaagc tgcatctaga ggcttccttc atttcctccg tcacctcaga   1560

gacatacacc tatgtcattt catttcctat ttttggaaga ggactcctta aatttggggg   1620

acttacatga ttcattttaa catctgagaa aagctttgaa ccctgggacg tggctagtca   1680

taaccttacc agatttttac acatgtatct atgcattttc tggacccgtt caacttttcc   1740

tttgaatcct ctctctgtgt tacccagtaa ctcatctgtc accaagcctt ggggattctt   1800

ccatctgatt gtgatgtgag ttgcacagct atgaaggctg tacactgcac gaatggaaga   1860

ggcacctgtc ccagaaaaag catcatggct atctgtgggt agtatgatgg gtgtttttag   1920

caggtaggag gcaaatatct tgaaaggggt tgtgaagagg tgttttttct aattggcatg   1980

aaggtgtcat acagatttgc aaagtttaat ggtgccttca tttgggatgc tactctagta   2040

ttccagacct gaagaatcac aataattttc tacctggtct ctccttgttc tgataatgaa   2100

aattatgata aggatgataa aagcacttac ttcgtgtccg actcttctga gcacctactt   2160

acatgcatta ctgcatgcac ttcttacaat aattctatga gataggtact attatcccca   2220

tttctttttt aaatgaagaa agtgaagtag gccgggcacg gtggctcacg cctgtaatcc   2280

cagggtgctg agattacagg tgtgagccac cctgcccagc cgtcaaaaga gtcttaatat   2340

atatatccag atggcatgtg tttactttat gttactacat gcacttggct gcataaatgt   2400

ggtacaagca ttctgtcttg aagggcaggt gcttcaggat accatataca gctcagaagt   2460

ttcttcttta ggcattaaat tttagcaaag atatctcatc tcttctttta aaccattttc   2520

tttttttgtg gttagaaaag ttatgtagaa aaaagtaaat gtgatttacg ctcattgtag   2580

aaaagctata aaatgaatac aattaaagct gttatttaat tagccagtga aaaactatta   2640

acaacttgtc tattacctgt tagtattatt gttgcattaa aaatgcatat actttaataa   2700

atgtatattg tattgtaaaa aaaaaaa                                       2727


<210>  354
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  354

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Pro Pro 
        195                 200                 205             


Leu Val Lys Val Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg 
    210                 215                 220                 


Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu 
225                 230                 235                 240 


Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val 
                245                 250                 255     


Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val 
            260                 265                 270         


Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His Pro Gly 
        275                 280                 285             


Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser Gly Thr 
    290                 295                 300                 


Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu 
305                 310                 315                 320 


Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg 
                325                 330                 335     


Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
            340                 345             


<210>  355
<211>  1140
<212>  DNA
<213>  Homosapiens

<400>  355
gttttactgg gcatctcctg agcctaggca atagctgtag ggtgacttct ggagccatcc     60

ccgtttcccc gccccccaaa agaagcggag atttaacggg gacgtgcggc cagagctggg    120

gaaatgggcc cgcgagccag gccggcgctt ctcctcctga tgcttttgca gaccgcggtc    180

ctgcaggggc gcttgctgcg ttcacactct ctgcactacc tcttcatggg tgcctcagag    240

caggaccttg gtctttcctt gtttgaagct ttgggctacg tggatgacca gctgttcgtg    300

ttctatgatc atgagagtcg ccgtgtggag ccccgaactc catgggtttc cagtagaatt    360

tcaagccaga tgtggctgca gctgagtcag agtctgaaag ggtgggatca catgttcact    420

gttgacttct ggactattat ggaaaatcac aaccacagca aggagtccca caccctgcag    480

gtcatcctgg gctgtgaaat gcaagaagac aacagtaccg agggctactg gaagtacggg    540

tatgatgggc aggaccacct tgaattctgc cctgacacac tggattggag agcagcagaa    600

cccagggcct ggcccaccaa gctggagtgg gaaaggcaca agattcgggc caggcagaac    660

agggcctacc tggagaggga ctgccctgca cagctgcagc agttgctgga gctggggaga    720

ggtgttttgg accaacaagt gcctcctttg gtgaaggtga cacatcatgt gacctcttca    780

gtgaccactc tacggtgtcg ggccttgaac tactaccccc agaacatcac catgaagtgg    840

ctgaaggata agcagccaat ggatgccaag gagttcgaac ctaaagacgt attgcccaat    900

ggggatggga cctaccaggg ctggataacc ttggctgtac ccccaaagtg ctgagattac    960

aggtgtgagc caccctgccc agccgtcaaa agagtcttaa tatatatatc cagatggcat   1020

gtgtttactt tatgttacta catgcacttg gctgcataaa tgtggtacaa gcattctgtc   1080

ttgaagggca ggtgcttcag gataccatat acagctcaga agtttcttct ttaggcatta   1140


<210>  356
<211>  276
<212>  PRT
<213>  Homosapiens

<400>  356

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Pro Pro 
        195                 200                 205             


Leu Val Lys Val Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg 
    210                 215                 220                 


Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu 
225                 230                 235                 240 


Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val 
                245                 250                 255     


Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val 
            260                 265                 270         


Pro Pro Lys Cys 
        275     


<210>  357
<211>  1045
<212>  DNA
<213>  Homosapiens

<400>  357
gagatttaac ggggacgtgc ggccagagct ggggaaatgg gcccgcgagc caggccggcg     60

cttctcctcc tgatgctttt gcagaccgcg gtcctgcagg ggcgcttgct gcgttcacac    120

tctctgcact acctcttcat gggtgcctca gagcaggacc ttggtctttc cttgtttgaa    180

gctttgggct acgtggatga ccagctgttc gtgttctatg atcatgagag tcgccgtgtg    240

gagccccgaa ctccatgggt ttccagtaga atttcaagcc agatgtggct gcagctgagt    300

cagagtctga aagggtggga tcacatgttc actgttgact tctggactat tatggaaaat    360

cacaaccaca gcaaggagtc ccacaccctg caggtcatcc tgggctgtga aatgcaagaa    420

gacaacagta ccgagggcta ctggaagtac gggtatgatg ggcaggacca ccttgaattc    480

tgccctgaca cactggattg gagagcagca gaacccaggg cctggcccac caagctggag    540

tgggaaaggc acaagattcg ggccaggcag aacagggcct acctggagag ggactgccct    600

gcacagctgc agcagttgct ggagctgggg agaggtgttt tggaccaaca agtgaccact    660

ctacggtgtc gggccttgaa ctactacccc cagaacatca ccatgaagtg gctgaaggat    720

aagcagccaa tggatgccaa ggagttcgaa cctaaagacg tattgcccaa tggggatggg    780

acctaccagg gctggataac cttggctgta ccccctgggg aagagcagag atatacgtgc    840

caggtggagc acccaggcct ggatcagccc ctcattgtga tctgggagcc ctcaccgtct    900

ggcaccctag tcattggagt catcagtgga attgctgttt ttgtcgtcat cttgttcatt    960

ggaattttgt tcataatatt aaggaagagg cagggttcaa gaggagccat ggggcactac   1020

gtcttagctg aacgtgagtg acacg                                         1045


<210>  358
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  358

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Thr Thr 
        195                 200                 205             


Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys 
    210                 215                 220                 


Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys 
225                 230                 235                 240 


Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu 
                245                 250                 255     


Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His 
            260                 265                 270         


Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser 
        275                 280                 285             


Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val 
    290                 295                 300                 


Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly 
305                 310                 315                 320 


Ser Arg Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
                325                 330                 


<210>  359
<211>  1085
<212>  DNA
<213>  Homosapiens

<400>  359
ctaaagttct gaaagacctg ttgcttttca ccaggaagtt ttactgggca tctcctgagc     60

ctaggcaata gctgtagggt gacttctgga gccatccccg tttccccgcc ccccaaaaga    120

agcggagatt taacggggac gtgcggccag agctggggaa atgggcccgc gagccaggcc    180

ggcgcttctc ctcctgatgc ttttgcagac cgcggtcctg caggggcgct tgctgcagtc    240

ccacaccctg caggtcatcc tgggctgtga aatgcaagaa gacaacagta ccgagggcta    300

ctggaagtac gggtatgatg ggcaggacca ccttgaattc tgccctgaca cactggattg    360

gagagcagca gaacccaggg cctggcccac caagctggag tgggaaaggc acaagattcg    420

ggccaggcag aacagggcct acctggagag ggactgccct gcacagctgc agcagttgct    480

ggagctgggg agaggtgttt tggaccaaca agtgcctcct ttggtgaagg tgacacatca    540

tgtgacctct tcagtgacca ctctacggtg tcgggccttg aactactacc cccagaacat    600

caccatgaag tggctgaagg ataagcagcc aatggatgcc aaggagttcg aacctaaaga    660

cgtattgccc aatggggatg ggacctacca gggctggata accttggctg taccccctgg    720

ggaagagcag agatatacgt gccaggtgga gcacccaggc ctggatcagc ccctcattgt    780

gatctgggag ccctcaccgt ctggcaccct agtcattgga gtcatcagtg gaattgctgt    840

ttttgtcgtc atcttgttca ttggaatttt gttcataata ttaaggaaga ggcagggttc    900

aagaggagcc atggggcact acgtcttagc tgaacgtgag tgacacgcag cctgcagact    960

cactgtggga aggagacaaa actagagact caaagaggga gtgcatttat gagctcttca   1020

tgtttcagga gagagttgaa cctaaacata gaaattgcct gacgaactcc ttgattttag   1080

ccttc                                                               1085


<210>  360
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  360

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Gln Ser His Thr Leu Gln Val 
            20                  25                  30          


Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr Trp 
        35                  40                  45              


Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp Thr 
    50                  55                  60                  


Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu Glu 
65                  70                  75                  80  


Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu Glu 
                85                  90                  95      


Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg Gly 
            100                 105                 110         


Val Leu Asp Gln Gln Val Pro Pro Leu Val Lys Val Thr His His Val 
        115                 120                 125             


Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro 
    130                 135                 140                 


Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala 
145                 150                 155                 160 


Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr 
                165                 170                 175     


Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr 
            180                 185                 190         


Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile 
        195                 200                 205             


Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly 
    210                 215                 220                 


Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile 
225                 230                 235                 240 


Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val Leu 
                245                 250                 255     


Ala Glu Arg Glu 
            260 


<210>  361
<211>  809
<212>  DNA
<213>  Homosapiens

<400>  361
ctaaagttct gaaagacctg ttgcttttca ccaggaagtt ttactgggca tctcctgagc     60

ctaggcaata gctgtagggt gacttctgga gccatccccg tttccccgcc ccccaaaaga    120

agcggagatt taacggggac gtgcggccag agctggggaa atgggcccgc gagccaggcc    180

ggcgcttctc ctcctgatgc ttttgcagac cgcggtcctg caggggcgct tgctgctgcc    240

tcctttggtg aaggtgacac atcatgtgac ctcttcagtg accactctac ggtgtcgggc    300

cttgaactac tacccccaga acatcaccat gaagtggctg aaggataagc agccaatgga    360

tgccaaggag ttcgaaccta aagacgtatt gcccaatggg gatgggacct accagggctg    420

gataaccttg gctgtacccc ctggggaaga gcagagatat acgtgccagg tggagcaccc    480

aggcctggat cagcccctca ttgtgatctg ggagccctca ccgtctggca ccctagtcat    540

tggagtcatc agtggaattg ctgtttttgt cgtcatcttg ttcattggaa ttttgttcat    600

aatattaagg aagaggcagg gttcaagagg agccatgggg cactacgtct tagctgaacg    660

tgagtgacac gcagcctgca gactcactgt gggaaggaga caaaactaga gactcaaaga    720

gggagtgcat ttatgagctc ttcatgtttc aggagagagt tgaacctaaa catagaaatt    780

gcctgacgaa ctccttgatt ttagccttc                                      809


<210>  362
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  362

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Leu Pro Pro Leu Val Lys Val 
            20                  25                  30          


Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu 
        35                  40                  45              


Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln 
    50                  55                  60                  


Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly 
65                  70                  75                  80  


Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu 
                85                  90                  95      


Glu Gln Arg Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro 
            100                 105                 110         


Leu Ile Val Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly 
        115                 120                 125             


Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile 
    130                 135                 140                 


Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly 
145                 150                 155                 160 


His Tyr Val Leu Ala Glu Arg Glu 
                165             


<210>  363
<211>  735
<212>  DNA
<213>  Homosapiens

<400>  363
ggggaaatgg gcccgcgagc caggccggcg cttctcctcc tgatgctttt gcagaccgcg     60

gtcctgcagg ggcgcttgct gcgttcacac tctctgcact acctcttcat gggtgcctca    120

gagcaggacc ttggtctttc cttgtttgaa gctttgggct acgtggatga ccagctgttc    180

gtgttctatg atcatgagag tcgccgtgtg gagccccgaa ctccatgggt ttccagtaga    240

atttcaagcc agatgtggct gcagctgagt cagagtctga aagggtggga tcacatgttc    300

actgttgact tctggactat tatggaaaat cacaaccaca gcaaggagtc ccacaccctg    360

caggtcatcc tgggctgtga aatgcaagaa gacaacagta ccgagggcta ctggaagtac    420

gggtatgatg ggcaggtgct tcaggatacc atatacagct cagaagtttc ttctttaggc    480

attaaatttt agcaaagata tctcatctct tcttttaaac cattttcttt ttttgtggtt    540

agaaaagtta tgtagaaaaa agtaaatgtg atttacgctc attgtagaaa agctataaaa    600

tgaatacaat taaagctgtt atttaattag ccagtgaaaa actattaaca acttgtctat    660

tacctgttag tattattgtt gcattaaaaa tgcatatact ttaataaatg tatattgtat    720

tgtataaaaa aaaaa                                                     735


<210>  364
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  364

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Val 
    130                 135                 140                 


Leu Gln Asp Thr Ile Tyr Ser Ser Glu Val Ser Ser Leu Gly Ile Lys 
145                 150                 155                 160 


Phe 
    


<210>  365
<211>  804
<212>  DNA
<213>  Homosapiens

<400>  365
aagaagcgga gatttaacgg ggacgtgcgg ccagagctgg ggaaatgggc ccgcgagcca     60

ggccggcgct tctcctcctg atgcttttgc agaccgcggt cctgcagggg cgcttgctgc    120

gttcacactc tctgcactac ctcttcatgg gtgcctcaga gcaggacctt ggtctttcct    180

tgtttgaagc tttgggctac gtggatgacc agctgttcgt gttctatgat catgagagtc    240

gccgtgtgga gccccgaact ccatgggttt ccagtagaat ttcaagccag atgtggctgc    300

agctgagtca gagtctgaaa gggtgggatc acatgttcac tgttgacttc tggactatta    360

tggaaaatca caaccacagc aaggtgacca ctctacggtg tcgggccttg aactactacc    420

cccagaacat caccatgaag tggctgaagg ataagcagcc aatggatgcc aaggagttcg    480

aacctaaaga cgtattgccc aatggggatg ggacctacca gggctggata accttggctg    540

taccccctgg ggaagagcag agatatacgt gccaggtgga gcacccaggc ctggatcagc    600

ccctcattgt gatctgggag ccctcaccgt ctggcaccct agtcattgga gtcatcagtg    660

gaattgctgt ttttgtcgtc atcttgttca ttggaatttt gttcataata ttaaggaaga    720

ggcagggttc aagaggagcc atggggcact acgtcttagc tgaacgtgag tgacacgcag    780

cctgcagact cactgtggga agga                                           804


<210>  366
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  366

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn 
        115                 120                 125             


Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu 
    130                 135                 140                 


Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly 
145                 150                 155                 160 


Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys 
                165                 170                 175     


Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu 
            180                 185                 190         


Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala 
        195                 200                 205             


Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg 
    210                 215                 220                 


Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val Leu Ala Glu 
225                 230                 235                 240 


Arg Glu 
        


<210>  367
<211>  1922
<212>  DNA
<213>  Homosapiens

<400>  367
ctaaagttct gaaagacctg ttgcttttca ccaggaagtt ttactgggca tctcctgagc     60

ctaggcaata gctgtagggt gacttctgga gccatccccg tttccccgcc ccccaaaaga    120

agcggagatt taacggggac gtgcggccag agctggggaa atgggcccgc gagccaggcc    180

ggcgcttctc ctcctgatgc ttttgcagac cgcggtcctg caggggcgct tgctgcgttc    240

acactctctg cactacctct tcatgggtgc ctcagagcag gaccttggtc tttccttgtt    300

tgaagctttg ggctacgtgg atgaccagct gttcgtgttc tatgatcatg agagtcgccg    360

tgtggagccc cgaactccat gggtttccag tagaatttca agccagatgt ggctgcagct    420

gagtcagagt ctgaaagggt gggatcacat gttcactgtt gacttctgga ctattatgga    480

aaatcacaac cacagcaagg tgcctccttt ggtgaaggtg acacatcatg tgacctcttc    540

agtgaccact ctacggtgtc gggccttgaa ctactacccc cagaacatca ccatgaagtg    600

gctgaaggat aagcagccaa tggatgccaa ggagttcgaa cctaaagacg tattgcccaa    660

tggggatggg acctaccagg gctggataac cttggctgta ccccctgggg aagagcagag    720

atatacgtgc caggtggagc acccaggcct ggatcagccc ctcattgtga tctgggagcc    780

ctcaccgtct ggcaccctag tcattggagt catcagtgga attgctgttt ttgtcgtcat    840

cttgttcatt ggaattttgt tcataatatt aaggaagagg cagggttcaa gaggagccat    900

ggggcactac gtcttagctg aacgtgagtg acacgcagcc tgcagactca ctgtgggaag    960

gagacaaaac tagagactca aagagggagt gcatttatga gctcttcatg tttcaggaga   1020

gagttgaacc taaacataga aattgcctga cgaactcctt gattttagcc ttctctgttc   1080

atttcctcaa aaagatttcc ccatttaggt ttctgagttc ctgcatgccg gtgatcccta   1140

gctgtgacct ctcccctgga actgtctctc atgaacctca agctgcatct agaggcttcc   1200

ttcatttcct ccgtcacctc agagacatac acctatgtca tttcatttcc tatttttgga   1260

agaggactcc ttaaatttgg gggacttaca tgattcattt taacatctga gaaaagcttt   1320

gaaccctggg acgtggctag tcataacctt accagatttt tacacatgta tctatgcatt   1380

ttctggaccc gttcaacttt tcctttgaat cctctctctg tgttacccag taactcatct   1440

gtcaccaagc cttggggatt cttccatctg attgtgatgt gagttgcaca gctatgaagg   1500

ctgtacactg cacgaatgga agaggcacct gtcccagaaa aagcatcatg gctatctgtg   1560

ggtagtatga tgggtgtttt tagcaggtag gaggcaaata tcttgaaagg ggttgtgaag   1620

aggtgttttt tctaattggc atgaaggtgt catacagatt tgcaaagttt aatggtgcct   1680

tcatttggga tgctactcta gtattccaga cctgaagaat cacaataatt ttctacctgg   1740

tctctccttg ttctgataat gaaaattatg ataaggatga taaaagcact tacttcgtgt   1800

ccgactcttc tgagcaccta cttacatgca ttactgcatg cacttcttac aataattcta   1860

tgagataggt actattatcc ccatttcttt tttaaatgaa gaaagtgaag taggccgggc   1920

ac                                                                  1922


<210>  368
<211>  256
<212>  PRT
<213>  Homosapiens

<400>  368

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Val Pro Pro Leu Val Lys Val Thr His His Val Thr Ser Ser Val 
        115                 120                 125             


Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr 
    130                 135                 140                 


Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu 
145                 150                 155                 160 


Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile 
                165                 170                 175     


Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val 
            180                 185                 190         


Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser 
        195                 200                 205             


Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe 
    210                 215                 220                 


Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg 
225                 230                 235                 240 


Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
                245                 250                 255     


<210>  369
<211>  781
<212>  DNA
<213>  Homosapiens

<400>  369
gagatttaac ggggacgtgc ggccagagct ggggaaatgg gcccgcgagc caggccggcg     60

cttctcctcc tgatgctttt gcagaccgcg gtcctgcagg ggcgcttgct gcagtcccac    120

accctgcagg tcatcctggg ctgtgaaatg caagaagaca acagtaccga gggctactgg    180

aagtacgggt atgatgggca ggaccacctt gaattctgcc ctgacacact ggattggaga    240

gcagcagaac ccagggcctg gcccaccaag ctggagtggg aaaggcacaa gattcgggcc    300

aggcagaaca gggcctacct ggagagggac tgccctgcac agctgcagca gttgctggag    360

ctggggagag gtgttttgga ccaacaagtg accactctac ggtgtcgggc cttgaactac    420

tacccccaga acatcaccat gaagtggctg aaggataagc agccaatgga tgccaaggag    480

ttcgaaccta aagacgtatt gcccaatggg gatgggacct accagggctg gataaccttg    540

gctgtacccc ctggggaaga gcagagatat acgtgccagg tggagcaccc aggcctggat    600

cagcccctca ttgtgatctg ggagccctca ccgtctggca ccctagtcat tggagtcatc    660

agtggaattg ctgtttttgt cgtcatcttg ttcattggaa ttttgttcat aatattaagg    720

aagaggcagg gttcaagagg agccatgggg cactacgtct tagctgaacg tgagtgacac    780

g                                                                    781


<210>  370
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  370

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Gln Ser His Thr Leu Gln Val 
            20                  25                  30          


Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr Trp 
        35                  40                  45              


Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp Thr 
    50                  55                  60                  


Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu Glu 
65                  70                  75                  80  


Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu Glu 
                85                  90                  95      


Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg Gly 
            100                 105                 110         


Val Leu Asp Gln Gln Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr 
        115                 120                 125             


Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met 
    130                 135                 140                 


Asp Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly 
145                 150                 155                 160 


Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln 
                165                 170                 175     


Arg Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile 
            180                 185                 190         


Val Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile 
        195                 200                 205             


Ser Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe 
    210                 215                 220                 


Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr 
225                 230                 235                 240 


Val Leu Ala Glu Arg Glu 
                245     


<210>  371
<211>  1280
<212>  DNA
<213>  Homosapiens

<400>  371
ctaaagttct gaaagacctg ttgcttttca ccaggaagtt ttactgggca tctcctgagc     60

ctaggcaata gctgtagggt gacttctgga gccatccccg tttccccgcc ccccaaaaga    120

agcggagatt taacggggac gtgcggccag agctggggaa atgggcccgc gagccaggcc    180

ggcgcttctc ctcctgatgc ttttgcagac cgcggtcctg caggggcgct tgctgccttt    240

gggctacgtg gatgaccagc tgttcgtgtt ctatgatcat gagagtcgcc gtgtggagcc    300

ccgaactcca tgggtttcca gtagaatttc aagccagatg tggctgcagc tgagtcagag    360

tctgaaaggg tgggatcaca tgttcactgt tgacttctgg actattatgg aaaatcacaa    420

ccacagcaag gagtcccaca ccctgcaggt catcctgggc tgtgaaatgc aagaagacaa    480

cagtaccgag ggctactgga agtacgggta tgatgggcag gaccaccttg aattctgccc    540

tgacacactg gattggagag cagcagaacc cagggcctgg cccaccaagc tggagtggga    600

aaggcacaag attcgggcca ggcagaacag ggcctacctg gagagggact gccctgcaca    660

gctgcagcag ttgctggagc tggggagagg tgttttggac caacaagtgc ctcctttggt    720

gaaggtgaca catcatgtga cctcttcagt gaccactcta cggtgtcggg ccttgaacta    780

ctacccccag aacatcacca tgaagtggct gaaggataag cagccaatgg atgccaagga    840

gttcgaacct aaagacgtat tgcccaatgg ggatgggacc taccagggct ggataacctt    900

ggctgtaccc cctggggaag agcagagata tacgtgccag gtggagcacc caggcctgga    960

tcagcccctc attgtgatct gggagccctc accgtctggc accctagtca ttggagtcat   1020

cagtggaatt gctgtttttg tcgtcatctt gttcattgga attttgttca taatattaag   1080

gaagaggcag ggttcaagag gagccatggg gcactacgtc ttagctgaac gtgagtgaca   1140

cgcagcctgc agactcactg tgggaaggag acaaaactag agactcaaag agggagtgca   1200

tttatgagct cttcatgttt caggagagag ttgaacctaa acatagaaat tgcctgacga   1260

actccttgat tttagccttc                                               1280


<210>  372
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  372

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Pro Leu Gly Tyr Val Asp Asp 
            20                  25                  30          


Gln Leu Phe Val Phe Tyr Asp His Glu Ser Arg Arg Val Glu Pro Arg 
        35                  40                  45              


Thr Pro Trp Val Ser Ser Arg Ile Ser Ser Gln Met Trp Leu Gln Leu 
    50                  55                  60                  


Ser Gln Ser Leu Lys Gly Trp Asp His Met Phe Thr Val Asp Phe Trp 
65                  70                  75                  80  


Thr Ile Met Glu Asn His Asn His Ser Lys Glu Ser His Thr Leu Gln 
                85                  90                  95      


Val Ile Leu Gly Cys Glu Met Gln Glu Asp Asn Ser Thr Glu Gly Tyr 
            100                 105                 110         


Trp Lys Tyr Gly Tyr Asp Gly Gln Asp His Leu Glu Phe Cys Pro Asp 
        115                 120                 125             


Thr Leu Asp Trp Arg Ala Ala Glu Pro Arg Ala Trp Pro Thr Lys Leu 
    130                 135                 140                 


Glu Trp Glu Arg His Lys Ile Arg Ala Arg Gln Asn Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Arg Asp Cys Pro Ala Gln Leu Gln Gln Leu Leu Glu Leu Gly Arg 
                165                 170                 175     


Gly Val Leu Asp Gln Gln Val Pro Pro Leu Val Lys Val Thr His His 
            180                 185                 190         


Val Thr Ser Ser Val Thr Thr Leu Arg Cys Arg Ala Leu Asn Tyr Tyr 
        195                 200                 205             


Pro Gln Asn Ile Thr Met Lys Trp Leu Lys Asp Lys Gln Pro Met Asp 
    210                 215                 220                 


Ala Lys Glu Phe Glu Pro Lys Asp Val Leu Pro Asn Gly Asp Gly Thr 
225                 230                 235                 240 


Tyr Gln Gly Trp Ile Thr Leu Ala Val Pro Pro Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys Gln Val Glu His Pro Gly Leu Asp Gln Pro Leu Ile Val 
            260                 265                 270         


Ile Trp Glu Pro Ser Pro Ser Gly Thr Leu Val Ile Gly Val Ile Ser 
        275                 280                 285             


Gly Ile Ala Val Phe Val Val Ile Leu Phe Ile Gly Ile Leu Phe Ile 
    290                 295                 300                 


Ile Leu Arg Lys Arg Gln Gly Ser Arg Gly Ala Met Gly His Tyr Val 
305                 310                 315                 320 


Leu Ala Glu Arg Glu 
                325 


<210>  373
<211>  533
<212>  DNA
<213>  Homosapiens

<400>  373
ctaaagttct gaaagacctg ttgcttttca ccaggaagtt ttactgggca tctcctgagc     60

ctaggcaata gctgtagggt gacttctgga gccatccccg tttccccgcc ccccaaaaga    120

agcggagatt taacggggac gtgcggccag agctggggaa atgggcccgc gagccaggcc    180

ggcgcttctc ctcctgatgc ttttgcagac cgcggtcctg caggggcgct tgctgcagcc    240

ctcaccgtct ggcaccctag tcattggagt catcagtgga attgctgttt ttgtcgtcat    300

cttgttcatt ggaattttgt tcataatatt aaggaagagg cagggttcaa gaggagccat    360

ggggcactac gtcttagctg aacgtgagtg acacgcagcc tgcagactca ctgtgggaag    420

gagacaaaac tagagactca aagagggagt gcatttatga gctcttcatg tttcaggaga    480

gagttgaacc taaacataga aattgcctga cgaactcctt gattttagcc ttc           533


<210>  374
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  374

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Gln Pro Ser Pro Ser Gly Thr 
            20                  25                  30          


Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu 
        35                  40                  45              


Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg 
    50                  55                  60                  


Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
65                  70                  75      


<210>  375
<211>  390
<212>  DNA
<213>  Homosapiens

<400>  375
atgtctggtc gcggcaaagg cggaaaaggc ttggggaagg gtggtgctaa gcgccatcgt     60

aaggtgctcc gggataacat ccagggcatt acaaaaccgg ctattcgccg tttggctcgg    120

cgcggtggcg tcaagcgcat ttccggtctt atctatgagg agactcgagg tgtgcttaag    180

gttttcttag agaacgttat tcgagacgcc gtcacctata cggagcacgc caagcgcaaa    240

actgtcacag ccatggatgt agtatatgcc ctaaaacgtc aggggcgcac tctgtatggc    300

ttcggcggct gaatctaaga atacgcggtc tcctgagaac ttcaaaaaac aaaaacaaaa    360

aaacccaaag gcccttttca gggccgctca                                     390


<210>  376
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  376

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  377
<211>  725
<212>  DNA
<213>  Homosapiens

<400>  377
catgcttttc gctggttatt acatcttgcg tttctctgtt gttatgtctg aaaccgtgcc     60

tgcagcttct gccagtgctg gtgtagccgc tatggagaaa cttccaacca agaagcgagg    120

gaggaagccg gctggcttga taagtgcaag tcgcaaagtg ccgaacctct ctgtgtccaa    180

gttgatcacc gaggcccttt cagtgtcaca ggaacgagta ggtatgtctt tggttgcgct    240

caagaaggca ttggccgctg ctggctacga cgtagagaag aataacagcc gcatcaaact    300

gtccctcaag agcttagtga acaagggaat cctggtgcaa accaggggta ctggtgcttc    360

cggttccttt aagcttagta agaaggtgat tcctaaatct accagaagca aggctaaaaa    420

gtcagtttct gccaagacca agaagctggt tttatccagg gactccaagt caccaaagac    480

tgctaaaacc aataagagag ccaagaagcc gagagcgaca actcctaaaa ctgttaggag    540

cgggagaaag gctaaaggag ccaagggtaa gcaacagcag aagagcccag tgaaggcaag    600

ggcttcgaag tcaaaattga cccaacatca tgaagttaat gttagaaagg ccacatctaa    660

gaagtaaaga gctttccggg aggccaattt ggaaagaacc caaaggctct tttaagagcc    720

accca                                                                725


<210>  378
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  378

Met Ser Glu Thr Val Pro Ala Ala Ser Ala Ser Ala Gly Val Ala Ala 
1               5                   10                  15      


Met Glu Lys Leu Pro Thr Lys Lys Arg Gly Arg Lys Pro Ala Gly Leu 
            20                  25                  30          


Ile Ser Ala Ser Arg Lys Val Pro Asn Leu Ser Val Ser Lys Leu Ile 
        35                  40                  45              


Thr Glu Ala Leu Ser Val Ser Gln Glu Arg Val Gly Met Ser Leu Val 
    50                  55                  60                  


Ala Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn 
65                  70                  75                  80  


Asn Ser Arg Ile Lys Leu Ser Leu Lys Ser Leu Val Asn Lys Gly Ile 
                85                  90                  95      


Leu Val Gln Thr Arg Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Ser 
            100                 105                 110         


Lys Lys Val Ile Pro Lys Ser Thr Arg Ser Lys Ala Lys Lys Ser Val 
        115                 120                 125             


Ser Ala Lys Thr Lys Lys Leu Val Leu Ser Arg Asp Ser Lys Ser Pro 
    130                 135                 140                 


Lys Thr Ala Lys Thr Asn Lys Arg Ala Lys Lys Pro Arg Ala Thr Thr 
145                 150                 155                 160 


Pro Lys Thr Val Arg Ser Gly Arg Lys Ala Lys Gly Ala Lys Gly Lys 
                165                 170                 175     


Gln Gln Gln Lys Ser Pro Val Lys Ala Arg Ala Ser Lys Ser Lys Leu 
            180                 185                 190         


Thr Gln His His Glu Val Asn Val Arg Lys Ala Thr Ser Lys Lys 
        195                 200                 205         


<210>  379
<211>  438
<212>  DNA
<213>  Homosapiens

<400>  379
atgcctgagc cagccaagtc tgctcccgcc ccgaagaagg gctccaagaa ggcagtgacc     60

aaagcgcaga agaaagatgg caagaagcgc aagcgcagcc gcaaggagag ttactctgtg    120

tacgtgtaca aggtgctgaa acaggtccat cccgacactg gcatctcttc caaggccatg    180

ggcatcatga attctttcgt taacgacata tttgagcgca tcgcgggcga ggcttcccgc    240

ctggcgcatt acaacaagcg ctcgaccatc acctccaggg agatccagac ggccgtgcgc    300

ctgctgcttc ccggagagct ggccaagcac gccgtgtcgg agggcaccaa ggccgtcacc    360

aagtacacca gctccaagta aacattccaa gtaagcgtct taacacctaa ccccaaaggc    420

tcttttaaga gccaccca                                                  438


<210>  380
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  380

Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  381
<211>  546
<212>  DNA
<213>  Homosapiens

<400>  381
aaagcggcca tgttttacat atttcttgat tttgtttgtt ttctcgtgag cttaggccgc     60

tggttttggt gatttttgtc tgattgcaat gtctggacgt ggtaagcaag gaggcaaagc    120

tcgcgccaaa gcgaaatccc gctcttctcg cgctggtctc cagttcccgg tgggccgagt    180

gcaccgcctg ctccgtaaag gcaactacgc agagcgggtt ggggcaggcg cgccggtgta    240

cctggcggcg gtgttagagt acctgaccgc cgagatcctg gagctggccg gcaacgcggc    300

tcgcgacaac aagaagactc gcatcatccc gcgccacttg cagctggcca tccgcaacga    360

cgaggagctc aacaaactgc taggccgggt gaccattgct cagggcggcg tccttcctaa    420

catccaggcc gtgcttctgc ctaagaagac cgagagtcac cacaaggcca agggcaagtg    480

atttgacagg tatctgagct cccggaaacg ctatcaaacc caaaggctct tttcagagcc    540

ccccta                                                               546


<210>  382
<211>  130
<212>  PRT
<213>  Homosapiens

<400>  382

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Ser Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Arg Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  383
<211>  785
<212>  DNA
<213>  Homosapiens

<400>  383
agtcccggcc agtgcctctg cttccggctc gaattgctct cgctcacgct tgccttcaac     60

atgtccgaga ctgcgcctgc cgcgcccgct gctccggccc ctgccgagaa gactcccgtg    120

aagaagaagg cccgcaagtc tgcaggtgcg gccaagcgca aagcgtctgg gcccccggtg    180

tccgagctca ttactaaagc tgttgccgcc tccaaggagc gcagcggcgt atctttggcc    240

gctctcaaga aagcgctggc agccgctggc tatgacgtgg agaagaacaa cagccgcatc    300

aagctgggtc tcaagagcct ggtgagcaag ggcaccctgg tgcagaccaa gggcaccggc    360

gcgtcgggtt ccttcaaact caacaagaag gcggcctctg gggaagccaa gcctaaggct    420

aaaaaggcag gcgcggccaa ggccaagaag ccagcaggag cggcgaagaa gcccaagaag    480

gcgacggggg cggccacccc caagaagagc gccaagaaga ccccaaagaa ggcgaagaag    540

ccggctgcag ctgctggagc caaaaaagcg aaaagcccga aaaaggcgaa agcagccaag    600

ccaaaaaagg cgcccaagag cccagcgaag gccaaagcag ttaaacccaa ggcggctaaa    660

ccaaagaccg ccaagcccaa ggcagccaag ccaaagaagg cggcagccaa gaaaaagtag    720

aaagttcctt tggccaactg cttagaagcc caacacaacc caaaggctct tttcagagcc    780

accca                                                                785


<210>  384
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  384

Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu 
1               5                   10                  15      


Lys Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys 
            20                  25                  30          


Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val 
        35                  40                  45              


Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys 
    50                  55                  60                  


Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr 
                85                  90                  95      


Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala 
            100                 105                 110         


Ser Gly Glu Ala Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys Ala 
        115                 120                 125             


Lys Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Ala Thr Gly Ala 
    130                 135                 140                 


Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Pro Ala Ala Ala Ala Gly Ala Lys Lys Ala Lys Ser Pro Lys Lys Ala 
                165                 170                 175     


Lys Ala Ala Lys Pro Lys Lys Ala Pro Lys Ser Pro Ala Lys Ala Lys 
            180                 185                 190         


Ala Val Lys Pro Lys Ala Ala Lys Pro Lys Thr Ala Lys Pro Lys Ala 
        195                 200                 205             


Ala Lys Pro Lys Lys Ala Ala Ala Lys Lys Lys 
    210                 215                 


<210>  385
<211>  523
<212>  DNA
<213>  Homosapiens

<400>  385
gattattttc tcaggtgttt gcaacagtgt tctaactatt aacgctacga tgcctgaacc     60

taccaagtct gctcctgccc caaagaaggg ctccaagaag gcggtgacta aggctcagaa    120

gaaggacggg aagaagcgca agcgcagccg caaggagagc tattcagtgt atgtgtacaa    180

ggtgctgaag caggtccatc ccgacaccgg catctcttcc aaggcaatgg ggatcatgaa    240

ttccttcgtc aacgacatct tcgagcgcat cgcaggcgag gcttcccgcc tggcgcatta    300

caacaagcgc tcgaccatca cctccaggga gatccagacg gccgtgcgcc tgctgcttcc    360

gggggagctg gccaagcacg ccgtgtcgga gggcaccaag gccgtcacca agtacaccag    420

ttccaagtaa ctttgccaag taagcatctt tacacctaat cccaaaggct cttttaagag    480

ccacgcatgt tttcaataaa tgagttgtaa tcatttcatt caa                      523


<210>  386
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  386

Met Pro Glu Pro Thr Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  387
<211>  829
<212>  DNA
<213>  Homosapiens

<400>  387
gattattttc tcaggtgttt gcaacagtgt tctaactatt aacgctacga tgcctgaacc     60

taccaagtct gctcctgccc caaagaaggg ctccaagaag gcggtgacta aggctcagaa    120

gaaggacggg aagaagcgca agcgcagccg caaggagagc tattcagtgt atgtgtacaa    180

ggtgctgaag caggtccatc ccgacaccgg catctcttcc aaggcaatgg ggatcatgaa    240

ttccttcgtc aacgacatct tcgagcgcat cgcaggcgag gcttcccgcc tggcgcatta    300

caacaagcgc tcgaccatca cctccaggga gatccagacg gccgtgcgcc tgctgcttcc    360

gggggagctg gccaagcacg ccgtgtcgga gggcaccaag gccgtcacca agtacaccag    420

ttccaagtaa ctttgccaag ggagagacat gaagacagag gagaaatgaa tgcataaaat    480

aactgataat atgaatctat acatagaact taggaagtct catctgcctg aaaatgactg    540

tgtggatccc acccaaatcc aactcatcct ggtttgctgc acactggttc atcaaaagaa    600

ggttaccgag gggaaggaac taaaggtgtt tgcacttcat gttacttttt gagtttataa    660

acataaaaac agaatttact tctgttacag acctagttac tgggaattca ttacttgcca    720

tggactacct ttgctaagaa aagtctgaat gagaagatgg caggacgtct gaaaaaaaaa    780

gttataatta ataaaatctg cggagaattg taaaaaaaaa aaaaaaaaa                829


<210>  388
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  388

Met Pro Glu Pro Thr Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  389
<211>  2229
<212>  DNA
<213>  Homosapiens

<400>  389
ctctaataac gttaggcttg gtatagaaga tgcagagaca tgctaaaatt tctcccccaa     60

ttattgccaa gcagaaactt ggacgatcga catggaaatt gtctccacag gaaacgaaac    120

tattactgaa tttgtcctcc ttggcttcta tgacatccct gaactgcatt tcttgttttt    180

tattgtattc actgctgtct atgtcttcat catcataggg aatatgctga ttattgtagc    240

agtggttagc tcccagaggc tccacaaacc catgtatatt ttcttggcga atctgtcctt    300

cctggatatt ctctacacct ccgcagtgat gccaaaaatg ctggagggct tcctgcaaga    360

agcaactatc tctgtggctg gttgcttgct ccagttcttt atcttcggct ctctagccac    420

agctgaatgc ttactgctgg ctgtcatggc atatgaccgc tacctggcaa tttgctaccc    480

actccactac ccactcctga tggggcccag acggtacatg gggctggtgg tcacaacctg    540

gctctctgga tttgtggtag atggactggt tgtggccctg gtggcccagc tgaggttctg    600

tggccccaac cacattgacc agttttactg tgactttatg cttttcgtgg gcctggcttg    660

ctcggatccc agagtggctc aggtgacaac tctcattctg tctgtgttct gcctcactat    720

tccttttgga ctgattctga catcttatgc cagaattgtg gtggcagtgc tgagagttcc    780

tgctggggca agcaggagaa gggctttctc cacatgctcc tcccacctag ctgtagtgac    840

cacattctat ggaacgctca tgatctttta tgttgcaccc tctgctgtcc attcccagct    900

cctctccaag gtcttctccc tgctctacac tgtggtcacc cctctcttca atcctgtgat    960

ctataccatg aggaacaagg aggtgcatca ggcacttcgg aagattctct gtatcaaaca   1020

aactgaaaca cttgattgaa ggagagtaat gaagatgtta ttttggactt cggacacctc   1080

cattggggac tcttccagga tgggttggag aggagtaact ttgtcttatt cgaccattct   1140

ctttgaactc ttctgcagtt atactaaaaa tgaaaatgat agggcaacaa ttttttaact   1200

tttattttaa gttcaagggt acatgtgcag gtttgttaca taggtaaact tgtgtcatgg   1260

gggtttactg tacagattat ttcatcaccc aggtattaag cctagtactc attaatcatt   1320

tttcctgatc ttctccctcc tcccaacctc caccctcaag taggattcag tgtgttgttc   1380

ccctctatgt atccatatgt tttcataatt tagctcccac ttatgagtga agacatacgg   1440

tatttgattt tctgttcctg tgttagtttg cgaaggatag tagcctccaa ttccatccat   1500

gtcaaataat caaaattatt taaactttga ttagttcttt attaaatatg tcataaatat   1560

ttaaaaataa tacagcaata ccaaaataaa cctagaaata ttgtttttta tattattgtt   1620

gtatgacatt taaaaatttc tttctatgtg tatttatatt tatacataca agttggatca   1680

tggagtttgt aatctggttt tccactgaac actgtgtcac gaacaacttt ttctattaac   1740

aagcatctat ttctttattc ttctgggctt catcgtatgg ctaaacatga tttgttattc   1800

tattttggga atttttagtt gtattctatt cttttactgt acattgttta catctggatt   1860

ttcctgtaat aaacttttag cacctaaatt gcaagatcta aggatatgtg tttttaaaaa   1920

tctaaagctg aattcctttt cttttaaact tcttttcttg tagaacattt caaacataca   1980

taaaagagaa gagcacagtg aacccccatg tactccatgt agccaccatc cagcttcaac   2040

atcaacattt tgctaatctt attttaatta gctacagctc cttgtttgtt agttttcatg   2100

gaaaatttta gggcaaattc cagatgttgt ataactatta tgttgtgtaa gttatgtatg   2160

tacatattcc acatatgtat ttagtataat ctgtgactaa taaagacatt ttaaaaaacc   2220

atgcccaca                                                           2229


<210>  390
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  390

Met Glu Ile Val Ser Thr Gly Asn Glu Thr Ile Thr Glu Phe Val Leu 
1               5                   10                  15      


Leu Gly Phe Tyr Asp Ile Pro Glu Leu His Phe Leu Phe Phe Ile Val 
            20                  25                  30          


Phe Thr Ala Val Tyr Val Phe Ile Ile Ile Gly Asn Met Leu Ile Ile 
        35                  40                  45              


Val Ala Val Val Ser Ser Gln Arg Leu His Lys Pro Met Tyr Ile Phe 
    50                  55                  60                  


Leu Ala Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Ser Ala Val Met 
65                  70                  75                  80  


Pro Lys Met Leu Glu Gly Phe Leu Gln Glu Ala Thr Ile Ser Val Ala 
                85                  90                  95      


Gly Cys Leu Leu Gln Phe Phe Ile Phe Gly Ser Leu Ala Thr Ala Glu 
            100                 105                 110         


Cys Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 
        115                 120                 125             


Tyr Pro Leu His Tyr Pro Leu Leu Met Gly Pro Arg Arg Tyr Met Gly 
    130                 135                 140                 


Leu Val Val Thr Thr Trp Leu Ser Gly Phe Val Val Asp Gly Leu Val 
145                 150                 155                 160 


Val Ala Leu Val Ala Gln Leu Arg Phe Cys Gly Pro Asn His Ile Asp 
                165                 170                 175     


Gln Phe Tyr Cys Asp Phe Met Leu Phe Val Gly Leu Ala Cys Ser Asp 
            180                 185                 190         


Pro Arg Val Ala Gln Val Thr Thr Leu Ile Leu Ser Val Phe Cys Leu 
        195                 200                 205             


Thr Ile Pro Phe Gly Leu Ile Leu Thr Ser Tyr Ala Arg Ile Val Val 
    210                 215                 220                 


Ala Val Leu Arg Val Pro Ala Gly Ala Ser Arg Arg Arg Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ser His Leu Ala Val Val Thr Thr Phe Tyr Gly Thr Leu 
                245                 250                 255     


Met Ile Phe Tyr Val Ala Pro Ser Ala Val His Ser Gln Leu Leu Ser 
            260                 265                 270         


Lys Val Phe Ser Leu Leu Tyr Thr Val Val Thr Pro Leu Phe Asn Pro 
        275                 280                 285             


Val Ile Tyr Thr Met Arg Asn Lys Glu Val His Gln Ala Leu Arg Lys 
    290                 295                 300                 


Ile Leu Cys Ile Lys Gln Thr Glu Thr Leu Asp 
305                 310                 315 


<210>  391
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  391
atgagtgcaa acacctccat ggtgactgag tttcttcttc tcggcttctc ccacctggcc     60

gacctccagg gcttgctctt ctctgtcttt ctcactatct acctgctgac cgtggcaggc    120

aatttcctca ttgtggtgct ggtctccact gatgctgccc tccagtcccc tatgtacttc    180

ttcctgcgca ccctctcggc cttggagatt ggctatacgt ctgtcacggt ccccctgcta    240

cttcaccacc tccttactgg ccggcgccac atctctcgct ctggatgtgc tctccagatg    300

ttcttcttcc tcttctttgg cgccacggag tgctgcctcc tggcagccat ggcctatgac    360

cgctatgcag ccatctgtga acccctccgc tacccactgc tgctgagcca ccgggtgtgt    420

ctacagctag ctgggtcggc gtgggcctgt ggggtgctgg tggggctggg ccacacccct    480

ttcatcttct ctttgccctt ctgcggcccc aataccatcc cgcagttctt ctgtgagatc    540

cagcctgtcc tgcagctggt atgtggagac acctcgctta atgaactgca gattatcctg    600

gcaacagccc tcctcatcct ctgccccttt ggcctcatcc tgggctccta cgggcgtatc    660

ctcgttacca tcttccggat cccatctgtt gcgggccgcc gcaaggcctt ctccacctgc    720

tcctcccacc tgatcgtggt ctccctcttc tatggcaccg cactctttat ctatattcgc    780

cctaaggcca gctacgatcc ggccactgac cctctggtgt ccctcttcta tgctgtggtc    840

acccccatcc tcaaccccat catctacagc ctgcggaaca cagaggtcaa agctgcccta    900

aagagaacca tccagaaaac ggtgcctatg gagatttga                           939


<210>  392
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  392

Met Ser Ala Asn Thr Ser Met Val Thr Glu Phe Leu Leu Leu Gly Phe 
1               5                   10                  15      


Ser His Leu Ala Asp Leu Gln Gly Leu Leu Phe Ser Val Phe Leu Thr 
            20                  25                  30          


Ile Tyr Leu Leu Thr Val Ala Gly Asn Phe Leu Ile Val Val Leu Val 
        35                  40                  45              


Ser Thr Asp Ala Ala Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Thr 
    50                  55                  60                  


Leu Ser Ala Leu Glu Ile Gly Tyr Thr Ser Val Thr Val Pro Leu Leu 
65                  70                  75                  80  


Leu His His Leu Leu Thr Gly Arg Arg His Ile Ser Arg Ser Gly Cys 
                85                  90                  95      


Ala Leu Gln Met Phe Phe Phe Leu Phe Phe Gly Ala Thr Glu Cys Cys 
            100                 105                 110         


Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Glu Pro 
        115                 120                 125             


Leu Arg Tyr Pro Leu Leu Leu Ser His Arg Val Cys Leu Gln Leu Ala 
    130                 135                 140                 


Gly Ser Ala Trp Ala Cys Gly Val Leu Val Gly Leu Gly His Thr Pro 
145                 150                 155                 160 


Phe Ile Phe Ser Leu Pro Phe Cys Gly Pro Asn Thr Ile Pro Gln Phe 
                165                 170                 175     


Phe Cys Glu Ile Gln Pro Val Leu Gln Leu Val Cys Gly Asp Thr Ser 
            180                 185                 190         


Leu Asn Glu Leu Gln Ile Ile Leu Ala Thr Ala Leu Leu Ile Leu Cys 
        195                 200                 205             


Pro Phe Gly Leu Ile Leu Gly Ser Tyr Gly Arg Ile Leu Val Thr Ile 
    210                 215                 220                 


Phe Arg Ile Pro Ser Val Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Leu Phe 
                245                 250                 255     


Ile Tyr Ile Arg Pro Lys Ala Ser Tyr Asp Pro Ala Thr Asp Pro Leu 
            260                 265                 270         


Val Ser Leu Phe Tyr Ala Val Val Thr Pro Ile Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Thr Glu Val Lys Ala Ala Leu Lys Arg Thr Ile 
    290                 295                 300                 


Gln Lys Thr Val Pro Met Glu Ile 
305                 310         


<210>  393
<211>  3009
<212>  DNA
<213>  Homosapiens

<400>  393
gtttgctttt agttctcatt gtgagatcac aagtggaggc tccaaccagt ccagaagttc     60

ctttctatgg ggaagctgtg gcagcaaggc cgtgaagaga gtctgactta attgcaaaga    120

cgaggtttca ccatgttgac caggctgatc tcaaacatct gacctcagga agtcagaggc    180

accaatgtga ggttccacct gctttccagc acattcttgg tttcctcact tctgctagac    240

aacgtttgat cagaaggaac agggaacgag aaggagctgc tggatgacga taagcctggg    300

aaagggaggc tgggtgagca gagacagaaa agaaacacct acctgctgtg acctcacaaa    360

cacccaggct gagttttgat aagacaggtt gaatcacact ggggtgacag cctcatccct    420

ccaggtacaa acaagaacag gccatggtta accaaagctc ccccatgggc ttcctccttc    480

tgggcttctc tgaacaccca gcactggaaa ggactctctt tgtggttgtc ttcacttcct    540

acctcttgac cctggtgggc aacacactca tcatcctgct gtctgtactg taccccaggc    600

tccactctcc aatgtacttt ttcctctctg acctctcctt cttggacctc tgctttacca    660

caagttgtgt cccccagatg ctggtcaacc tctggggccc aaagaagacc atcagcttcc    720

tgggatgctc tgtccagctc ttcatcttcc tgtccctggg gaccactgag tgcatcctcc    780

tgacagtgat ggcctttgac cgatacgtgg ctgtctgcca gcccctccac tatgccacca    840

tcatccaccc ccgcctgtgc tggcagctgg catctgtggc ctgggttatg agtctggttc    900

aatcgatagt ccagacacca tccaccctcc acttgccctt ctgtccccac cagcagatag    960

atgacttttt atgtgaggtc ccatctctga ttcgactctc ctgtggagat acctcctaca   1020

atgaaatcca gttggctgtg tccagtgtca tcttcgtggt tgtgcctctc agcctcatcc   1080

ttgcctctta tggagccact gcccaggcag tgctgaggat taactctgcc acagcatgga   1140

gaaaggcctt tgggacctgc tcctcccatc tcactgtggt caccctcttc tacagctcag   1200

tcattgctgt ctacctccag cccaaaaatc cgtatgccca agggaggggc aagttctttg   1260

gtctcttcta tgcagtgggc actccttcac ttaaccctct cgtatacacc ctgaggaaca   1320

aggagataaa gcgagcactc aggaggttac tagggaagga aagagactcc agggaaagct   1380

ggagagctgc ttaatatact ttcgaaagta agaagagttt cttcaagatt tatgaacatg   1440

ttaagttttc cagactacta cccttcccac atacacctga gccactgtgg tgggtcacag   1500

tgtggctatg ttatctatga gagggagaat gagaaagaga gggacagaga gataaaagaa   1560

attgggtgag aggagatagg tagctccata aggcacacaa attcaaatat tatcattcct   1620

atcactgtcc attcttaata tttctatcct ccattctgtt ctttttactg tcatcacttc   1680

tatagatttc ctaactccac catgcctatt tctggttata taattgctct ccaattgtca   1740

tgtcagtgta ggggaactac tccatcatag cattctggac accttgcatg tatctacgta   1800

ggtcatgtaa gcaaaggctt gaagaacagc taatctgaga tttagaagaa tgctttttga   1860

tcctcctgga atatgagagg atgggaggcc ctttagagcc tgcctcaatg ccatctctca   1920

ctctccttct tatatccctg ggagtatgtc atgtgacaag tctttactgt ctcccaggtt   1980

ttggatggag catggggttt tctgccccac accctttagg atatagctga agaatataat   2040

gaggaatagc tggattctag aactgactcc tcaccagtgg tatattccac aacagtgtca   2100

cagtcgtctg gcccctttgg tttccgtgtc atcctttttg gtgtgtagga caaggagcca   2160

gggaattggc acgtttggct tttacttctt ttttatatgt aaataataag ccatctaagt   2220

gtaaaagtgg ctcatatctt ctccagccaa atcagctagg ccatggcctt gccttgcttc   2280

tcatgagtgt gcttgacagt catcaccgtc actctatctt catttctggt tcttaccgtg   2340

ttagcttagt tcattcaagc tactatcaca agctacacat aaattgggtg gtttataaat   2400

aacaaacatt tctttcttac agttctggag gctggaaact ccaagattaa ggcagatttc   2460

atgcctattg agggcctgct ttctgattat agaaggtgac ttcttgctgt gcccacacat   2520

ggtgaaaggg actaccaact ctctggagtc tcttttatga gggcactaat tccaattatg   2580

aagcctcttc cctcatgacc taatcactgc ccaaaggccc catgttctaa tgccatcatc   2640

ttggtggttt aggatttcaa catatgaatt ttggaaggac ataagcattc aaccccctgc   2700

acatgtcttc tttcctactt cctcaaggtt ctttctgtcc agttgctcct tcttctattg   2760

accctttttt gccttctctt tctccttcac tgcctcaagt tacagccaga ggaaaggagg   2820

aactaaaact tagcaaatct ataatcacat gcaaatacac agaatggatt gttacaacca   2880

aaatgcaggc tctattgttt tcaatttagc agcctttcaa atgtatatgg ttctggccac   2940

attaaagttg caaataacac tttttttgag actgaaataa aggtgaaata ttggaaaaaa   3000

aaaaaaaaa                                                           3009


<210>  394
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  394

Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15      


Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 
            20                  25                  30          


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val 
        35                  40                  45              


Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu 
    50                  55                  60                  


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser 
                85                  90                  95      


Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110         


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140                 


Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser 
145                 150                 155                 160 


Thr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu 
                165                 170                 175     


Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro 
        195                 200                 205             


Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu 
    210                 215                 220                 


Arg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240 


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255     


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe 
            260                 265                 270         


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr 
        275                 280                 285             


Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly 
    290                 295                 300                 


Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 
305                 310                 315     


<210>  395
<211>  1137
<212>  DNA
<213>  Homosapiens

<400>  395
atggtctggg ggaaaatttg ctggttcagc cagagggctg gatggacagt gtttgctgag     60

tcacagatat ctctctcatg tagcctttgt ctccacagtg gtgaccagga ggcacagaac    120

ccaaacctgg tatctcagct ctgtggcgtc tttcttcaaa atgagacgaa tgaaaccata    180

catatgcaga tgagcatggc agtgggacag caggccctgc ccttgaatat cattgccccc    240

aaggctgtgc tggtctccct ctgtggggtc ttattgaatg gcactgtctt ctggctgctt    300

tgctgtgggg ccacgaatcc ctacatggta tacatcctcc acctggtcgc tgctgacgtg    360

atctatcttt gctgctcggc agtggggttc ttacaggtga ctctgctaac ttatcatgga    420

gtcgtgtttt ttatccctga tttcctggcc atattgtctc ccttctcctt tgaggtgtgt    480

ctctgtctcc tggtggccat cagcacagag cggtgtgtgt gtgtcctctt ccccatctgg    540

tacagatgcc accgcccaaa atacacatct aatgttgtct gcaccctcat ctggggcctg    600

cctttttgca tcaacatagt aaaatcactt ttcctaactt actggaaaca tgtaaaggca    660

tgtgtcatat ttctaaagct ttctgggctc ttccatgcta tcctttcact tgtgatgtgt    720

gtgtcgagtc tgactctact cattagattc ctgtgctgct cccagcagca aaaggccacc    780

agggtctatg cggtggtgca gatctcggcc cccatgttcc tactctgggc cctacccctg    840

agcgtggcac ccctcataac agatttcaaa atgtttgtca ccacctccta tttaatttcc    900

ttgttcctca ttataaacag cagcgccaac cctatcattt atttctttgt ggggagcctc    960

agaaagaaaa ggctgaagga atctctcaga gtgattctcc aacgggcgtt agcagataag   1020

ccagaggtgg ggaggaacaa aaaggcagct ggcatcgacc caatggagca accacactct   1080

actcagcatg tggagaacct tcttcccagg gagcacaggg tcgatgtgga aacataa      1137


<210>  396
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  396

Met Val Trp Gly Lys Ile Cys Trp Phe Ser Gln Arg Ala Gly Trp Thr 
1               5                   10                  15      


Val Phe Ala Glu Ser Gln Ile Ser Leu Ser Cys Ser Leu Cys Leu His 
            20                  25                  30          


Ser Gly Asp Gln Glu Ala Gln Asn Pro Asn Leu Val Ser Gln Leu Cys 
        35                  40                  45              


Gly Val Phe Leu Gln Asn Glu Thr Asn Glu Thr Ile His Met Gln Met 
    50                  55                  60                  


Ser Met Ala Val Gly Gln Gln Ala Leu Pro Leu Asn Ile Ile Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Val Ser Leu Cys Gly Val Leu Leu Asn Gly Thr Val 
                85                  90                  95      


Phe Trp Leu Leu Cys Cys Gly Ala Thr Asn Pro Tyr Met Val Tyr Ile 
            100                 105                 110         


Leu His Leu Val Ala Ala Asp Val Ile Tyr Leu Cys Cys Ser Ala Val 
        115                 120                 125             


Gly Phe Leu Gln Val Thr Leu Leu Thr Tyr His Gly Val Val Phe Phe 
    130                 135                 140                 


Ile Pro Asp Phe Leu Ala Ile Leu Ser Pro Phe Ser Phe Glu Val Cys 
145                 150                 155                 160 


Leu Cys Leu Leu Val Ala Ile Ser Thr Glu Arg Cys Val Cys Val Leu 
                165                 170                 175     


Phe Pro Ile Trp Tyr Arg Cys His Arg Pro Lys Tyr Thr Ser Asn Val 
            180                 185                 190         


Val Cys Thr Leu Ile Trp Gly Leu Pro Phe Cys Ile Asn Ile Val Lys 
        195                 200                 205             


Ser Leu Phe Leu Thr Tyr Trp Lys His Val Lys Ala Cys Val Ile Phe 
    210                 215                 220                 


Leu Lys Leu Ser Gly Leu Phe His Ala Ile Leu Ser Leu Val Met Cys 
225                 230                 235                 240 


Val Ser Ser Leu Thr Leu Leu Ile Arg Phe Leu Cys Cys Ser Gln Gln 
                245                 250                 255     


Gln Lys Ala Thr Arg Val Tyr Ala Val Val Gln Ile Ser Ala Pro Met 
            260                 265                 270         


Phe Leu Leu Trp Ala Leu Pro Leu Ser Val Ala Pro Leu Ile Thr Asp 
        275                 280                 285             


Phe Lys Met Phe Val Thr Thr Ser Tyr Leu Ile Ser Leu Phe Leu Ile 
    290                 295                 300                 


Ile Asn Ser Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Leu 
305                 310                 315                 320 


Arg Lys Lys Arg Leu Lys Glu Ser Leu Arg Val Ile Leu Gln Arg Ala 
                325                 330                 335     


Leu Ala Asp Lys Pro Glu Val Gly Arg Asn Lys Lys Ala Ala Gly Ile 
            340                 345                 350         


Asp Pro Met Glu Gln Pro His Ser Thr Gln His Val Glu Asn Leu Leu 
        355                 360                 365             


Pro Arg Glu His Arg Val Asp Val Glu Thr 
    370                 375             


<210>  397
<211>  971
<212>  DNA
<213>  Homosapiens

<400>  397
gattgcttga ggagagaagt atgtgatcag aaagcattct ttgtctatta actcctgccc     60

agcaaaagtg aaagaaaatt catgggagca tgcaagaaca aagagcacag caaagctgga    120

caaacacagc aatccaggca ggggatttcc aactcaactc tggtatgtaa gctgcatgca    180

aagtcctttt tctgtctctg gtttctggcc ccttgtctgc agagatggct cccaatgctt    240

cctgcctctg tgtgcatgtc cgttccgagg aatgggattt aatgaccttt gatgccaacc    300

catatgacag cgtgaaaaaa atcaaagaac atgtccggtc taagaccaag gttcctgtgc    360

aggaccaggt tcttttgctg ggctccaaga tcttaaagcc acggagaagc ctctcatctt    420

acggcattga caaagagaag accatccacc ttaccctgaa agtggtgaag cccagtgatg    480

aggagctgcc cttgtttctt gtggagtcag gtgatgaggc aaagaggcac ctcctccagg    540

tgcgaaggtc cagctcagtg gcacaagtga aagcaatgat cgagactaag acgggtataa    600

tccctgagac ccagattgtg acttgcaatg gaaagagact ggaagatggg aagatgatgg    660

cagattacgg catcagaaag ggcaacttac tcttcctggc atcttattgt attggagggt    720

gaccaccctg ggcatggggt gttggcaggg gtcaaaaagc ttatttcttt taatctctta    780

ctcaacgaac acatcttctg atgatttccc aaaattaatg agaatgagat gagtagagta    840

agatttgggt gggatgggta ggatgaagta tattgcccaa ctctatgttt ctttgattct    900

aacacaatta attaagtgac atgattttta ctaatgtatt actgagacta gtaaataaat    960

ttttaagcca a                                                         971


<210>  398
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  398

Met Ala Pro Asn Ala Ser Cys Leu Cys Val His Val Arg Ser Glu Glu 
1               5                   10                  15      


Trp Asp Leu Met Thr Phe Asp Ala Asn Pro Tyr Asp Ser Val Lys Lys 
            20                  25                  30          


Ile Lys Glu His Val Arg Ser Lys Thr Lys Val Pro Val Gln Asp Gln 
        35                  40                  45              


Val Leu Leu Leu Gly Ser Lys Ile Leu Lys Pro Arg Arg Ser Leu Ser 
    50                  55                  60                  


Ser Tyr Gly Ile Asp Lys Glu Lys Thr Ile His Leu Thr Leu Lys Val 
65                  70                  75                  80  


Val Lys Pro Ser Asp Glu Glu Leu Pro Leu Phe Leu Val Glu Ser Gly 
                85                  90                  95      


Asp Glu Ala Lys Arg His Leu Leu Gln Val Arg Arg Ser Ser Ser Val 
            100                 105                 110         


Ala Gln Val Lys Ala Met Ile Glu Thr Lys Thr Gly Ile Ile Pro Glu 
        115                 120                 125             


Thr Gln Ile Val Thr Cys Asn Gly Lys Arg Leu Glu Asp Gly Lys Met 
    130                 135                 140                 


Met Ala Asp Tyr Gly Ile Arg Lys Gly Asn Leu Leu Phe Leu Ala Ser 
145                 150                 155                 160 


Tyr Cys Ile Gly Gly 
                165 


<210>  399
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  399
atggttaacc aaagctccac accgggcttc ctccttctgg gcttctctga acacccaggg     60

ctggaaagga ctctcttcgt ggttgtcttc acttcctacc tcctaaccct agtgggcaac    120

acactcatca tcctgctgtc tgcgctggac cccaagctcc actctccaat gtactttttc    180

ctctccaacc tctccttctt ggacctctgt ttcaccacga gttgtgttcc ccaaatgctg    240

gtcaacctct ggggcccaaa gaagaccatc agcttcctgg actgctctgt ccagatcttc    300

atcttcctgt ccctggggac aactgagtgc atcctcttga cagtgatggc ttttgatcgc    360

tacgtggctg tctgccagcc cctccactat gccaccatca tccacccccg cctgtgctgg    420

cagctggcat ctgtggcctg ggtcattggg ctagtggagt cagtggtcca gacaccatcc    480

accctgcacc tgcccttctg ccccgatcgg caggtggatg attttgtctg tgaggtccca    540

gctctaattc gactctcctg tgaagacacc tcctacaatg agatccaggt ggctgttgcc    600

agtgtcttca tcttggttgt gcctctcagc ctcatccttg tctcttacgg agccattacc    660

tgggcagtgc tgaggattaa ctctgcaaaa gggcggagga aagcttttgg gacctgctcc    720

tcccatctca ctgtggtcac cctcttctac agctcagtca ttgctgtcta cctccagccc    780

aaaaatccct atgcccaaga gaggggcaag ttctttggtc tcttctatgc agtgggcact    840

ccttcactta accctctcat atacaccctg aggaacaagg aggtaaccag ggcattcagg    900

agattgctgg ggaaggaaat ggggctcaca caaagctga                           939


<210>  400
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  400

Met Val Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15      


Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 
            20                  25                  30          


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
        35                  40                  45              


Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
    50                  55                  60                  


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                85                  90                  95      


Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110         


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140                 


Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
145                 150                 155                 160 


Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                165                 170                 175     


Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
            180                 185                 190         


Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
        195                 200                 205             


Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
    210                 215                 220                 


Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240 


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255     


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
            260                 265                 270         


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
    290                 295                 300                 


Lys Glu Met Gly Leu Thr Gln Ser 
305                 310         


<210>  401
<211>  4039
<212>  DNA
<213>  Homosapiens

<400>  401
agagccgcgg gggccgtagg aagccaacct tccctgcttc tccggggccc tcgccccctc     60

ctccccacaa aatcagggat ggaggcgcct ccccggcacc ctcttagcag ccctccccag    120

gaaaagtgtc ccccctgagc tcctaacgct ccccaacagc tacccctgcc ccccacgcca    180

tggggcccgg ggcccctttt gcccgggtgg ggtggccact gccgcttctg gttgtgatgg    240

cggcaggggt ggctccggtg tgggcctccc actcccccca tctcccgcgg cctcactcgc    300

gggtcccccc gcacccctcc tcagaacggc gcgcagtgta catcggggca ctgtttccca    360

tgagcggggg ctggccaggg ggccaggcct gccagcccgc ggtggagatg gcgctggagg    420

acgtgaatag ccgcagggac atcctgccgg actatgagct caagctcatc caccacgaca    480

gcaagtgtga tccaggccaa gccaccaagt acctatatga gctgctctac aacgacccta    540

tcaagatcat ccttatgcct ggctgcagct ctgtctccac gctggtggct gaggctgcta    600

ggatgtggaa cctcattgtg ctttcctatg gctccagctc accagccctg tcaaaccggc    660

agcgtttccc cactttcttc cgaacgcacc catcagccac actccacaac cctacccgcg    720

tgaaactctt tgaaaagtgg ggctggaaga agattgctac catccagcag accactgagg    780

tcttcacttc gactctggac gacctggagg aacgagtgaa ggaggctgga attgagatta    840

ctttccgcca gagtttcttc tcagatccag ctgtgcccgt caaaaacctg aagcgccagg    900

atgcccgaat catcgtggga cttttctatg agactgaagc ccggaaagtt ttttgtgagg    960

tgtacaagga gcgtctcttt gggaagaagt acgtctggtt cctcattggg tggtatgctg   1020

acaattggtt caagatctac gacccttcta tcaactgcac agtggatgag atgactgagg   1080

cggtggaggg ccacatcaca actgagattg tcatgctgaa tcctgccaat acccgcagca   1140

tttccaacat gacatcccag gaatttgtgg agaaactaac caagcgactg aaaagacacc   1200

ctgaggagac aggaggcttc caggaggcac cgctggccta tgatgccatc tgggccttgg   1260

cactggccct gaacaagaca tctggaggag gcggccgttc tggtgtgcgc ctggaggact   1320

tcaactacaa caaccagacc attaccgacc aaatctaccg ggcaatgaac tcttcgtcct   1380

ttgagggtgt ctctggccat gtggtgtttg atgccagcgg ctctcggatg gcatggacgc   1440

ttatcgagca gcttcagggt ggcagctaca agaagattgg ctactatgac agcaccaagg   1500

atgatctttc ctggtccaaa acagataaat ggattggagg gtccccccca gctgaccaga   1560

ccctggtcat caagacattc cgcttcctgt cacagaaact ctttatctcc gtctcagttc   1620

tctccagcct gggcattgtc ctagctgttg tctgtctgtc ctttaacatc tacaactcac   1680

atgtccgtta tatccagaac tcacagccca acctgaacaa cctgactgct gtgggctgct   1740

cactggcttt agctgctgtc ttccccctgg ggctcgatgg ttaccacatt gggaggaacc   1800

agtttccttt cgtctgccag gcccgcctct ggctcctggg cctgggcttt agtctgggct   1860

acggttccat gttcaccaag atttggtggg tccacacggt cttcacaaag aaggaagaaa   1920

agaaggagtg gaggaagact ctggaaccct ggaagctgta tgccacagtg ggcctgctgg   1980

tgggcatgga tgtcctcact ctcgccatct ggcagatcgt ggaccctctg caccggacca   2040

ttgagacatt tgccaaggag gaacctaagg aagatattga cgtctctatt ctgccccagc   2100

tggagcattg cagctccagg aagatgaata catggcttgg cattttctat ggttacaagg   2160

ggctgctgct gctgctggga atcttccttg cttatgagac caagagtgtg tccactgaga   2220

agatcaatga tcaccgggct gtgggcatgg ctatctacaa tgtggcagtc ctgtgcctca   2280

tcactgctcc tgtcaccatg attctgtcca gccagcagga tgcagccttt gcctttgcct   2340

ctcttgccat agttttctcc tcctatatca ctcttgttgt gctctttgtg cccaagatgc   2400

gcaggctgat cacccgaggg gaatggcagt cggaggcgca ggacaccatg aagacagggt   2460

catcgaccaa caacaacgag gaggagaagt cccggctgtt ggagaaggag aaccgtgaac   2520

tggaaaagat cattgctgag aaagaggagc gtgtctctga actgcgccat caactccagt   2580

ctcggcagca gctccgctcc cggcgccacc caccgacacc cccagaaccc tctgggggcc   2640

tgcccagggg accccctgag ccccccgacc ggcttagctg tgatgggagt cgagtgcatt   2700

tgctttataa gtgagggtag ggtgagggag gacaggccag tagggggagg gaaagggaga   2760

ggggaagggc aggggactca ggaagcaggg ggtccccatc cccagctggg aagaacatgc   2820

tatccaatct catctcttgt aaatacatgt ccccctgtga gttctgggct gatttgggtc   2880

tctcatacct ctgggaaaca gacctttttc tctcttactg cttcatgtaa ttttgtatca   2940

cctcttcaca atttagttcg tacctggctt gaagctgctc actgctcaca cgctgcctcc   3000

tcagcagcct cactgcatct ttctcttccc atgcaacacc ctcttctagt taccacggca   3060

acccctgcag ctcctctgcc tttgtgctct gttcctgtcc agcaggggtc tcccaacaag   3120

tgctctttcc accccaaagg ggcctctcct tttctccact gtcataatct ctttccatct   3180

tacttgccct tctatacttt ctcacatgtg gctccccctg aattttgctt cctttgggag   3240

ctcattcttt tcgccaaggc tcacatgctc cttgcctctg ctctgtgcac tcacgctcag   3300

cacacatgca tcctcccctc tcctgcgtgt gcccactgaa catgctcatg tgtacacacg   3360

cttttcccgt atgctttctt catgttcagt cacatgtgct ctcgggtgcc ctgcattcac   3420

agctacgtgt gcccctctca tggtcatggg tctgcccttg agcgtgtttg ggtaggcatg   3480

tgcaatttgt ctagcatgct gagtcatgtc tttcctattt gcacacgtcc atgtttatcc   3540

atgtactttc cctgtgtacc ctccatgtac cttgtgtact ttcttccctt aaatcatggt   3600

attcttctga cagagccata tgtaccctac cctgcacatt gttatgcact tttccccaat   3660

tcatgtttgg tggggccatc cacaccctct ccttgtcaca gaatctccat ttctgctcag   3720

attcccccca tctccattgc attcatgtac taccctcagt ctacactcac aatcatcttc   3780

tcccaagact gctccctttt gttttgtgtt tttttgaggg gaattaagga aaaataagtg   3840

ggggcaggtt tggagagctg cttccagtgg atagttgatg agaatcctga ccaaaggaag   3900

gcacccttga ctgttgggat agacagatgg acctatgggg tgggaggtgg tgtccctttc   3960

acactgtggt gtctcttggg gaaggatctc cccgaatctc aataaaccag tgaacagtgt   4020

gactcggcaa aaaaaaaaa                                                4039


<210>  402
<211>  844
<212>  PRT
<213>  Homosapiens

<400>  402

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30          


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45              


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60                  


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80  


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95      


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110         


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125             


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140                 


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160 


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175     


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190         


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205             


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220                 


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240 


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255     


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270         


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285             


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300                 


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320 


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335     


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350         


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365             


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380                 


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400 


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415     


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430         


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445             


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460                 


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480 


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495     


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510         


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525             


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540                 


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560 


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575     


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590         


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605             


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620                 


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640 


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655     


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670         


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685             


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700                 


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720 


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735     


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750         


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765             


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780                 


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800 


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815     


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830         


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840                 


<210>  403
<211>  4294
<212>  DNA
<213>  Homosapiens

<400>  403
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgc tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtccgaat ctgctccaag    540

tcttatttga ccctggaaaa tgggaaggtt ttcctgacgg gtggggacct cccagctctg    600

gacggagccc gggtggattt ccggtgtgac cccgacttcc atctggtggg cagctcccgg    660

agcatctgta gtcagggcca gtggagcacc cccaagcccc actgccaggt gaatcgaacg    720

ccacactcag aacggcgcgc agtgtacatc ggggcactgt ttcccatgag cgggggctgg    780

ccagggggcc aggcctgcca gcccgcggtg gagatggcgc tggaggacgt gaatagccgc    840

agggacatcc tgccggacta tgagctcaag ctcatccacc acgacagcaa gtgtgatcca    900

ggccaagcca ccaagtacct atatgagctg ctctacaacg accctatcaa gatcatcctt    960

atgcctggct gcagctctgt ctccacgctg gtggctgagg ctgctaggat gtggaacctc   1020

attgtgcttt cctatggctc cagctcacca gccctgtcaa accggcagcg tttccccact   1080

ttcttccgaa cgcacccatc agccacactc cacaacccta cccgcgtgaa actctttgaa   1140

aagtggggct ggaagaagat tgctaccatc cagcagacca ctgaggtctt cacttcgact   1200

ctggacgacc tggaggaacg agtgaaggag gctggaattg agattacttt ccgccagagt   1260

ttcttctcag atccagctgt gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc   1320

gtgggacttt tctatgagac tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt   1380

ctctttggga agaagtacgt ctggttcctc attgggtggt atgctgacaa ttggttcaag   1440

atctacgacc cttctatcaa ctgcacagtg gatgagatga ctgaggcggt ggagggccac   1500

atcacaactg agatcgtcat gctgaatcct gccaataccc gcagcatttc caacatgaca   1560

tcccaggaat ttgtggagaa actaaccaag cgactgaaaa gacaccctga ggagacagga   1620

ggcttccagg aggcaccgct ggcctatgat gccatctggg ccttggcact ggccctgaac   1680

aagacatctg gaggaggcag ccgttccggc gtgcgcctgg aggacttcaa ctacaacaac   1740

cagaccatta ccgaccaaat ctaccgggca atgaactcct cgtcctttga gggtgtctct   1800

ggccatgtgg tgtttgatgc cagcggctct cggatggcat ggacgcttat cgagcagctt   1860

cagggtggca gctacaagaa gattggctac tatgacagca ccaaggatga tctttcctgg   1920

tccaaaacag ataaatggat tgttatatcc agaactcaca gcccaacctg acaacctgac   1980

tgctgtgggc tgctcactgg ctttagctgc tgtcttcccc ctggggctcg atggttacca   2040

cattgggagg aaccagtttc ctttcgtctg ccaggcccgc ctctggctcc tgggcctggg   2100

ctttagtctg ggctacggtt ccatgttcac caagatttgg tgggtccaca cggtcttcac   2160

aaagaaggaa gaaaagaagg agtggaggaa gactctggaa ccctggaagc tgtatgccac   2220

agtgggcctg ctggtgggca tggatgtcct cactctcgcc atctggcaga tcgtggaccc   2280

tctgcaccgg accattgaga catttgccaa ggaggaacct aaggaagata ttgacgtctc   2340

tattctgccc cagctggagc attgcagctc caggaagatg aatacatggc ttggcatttt   2400

ctatggttac aaggggctgc tgctgctgct gggaatcttc cttgcttatg agaccaagag   2460

tgtgtccact gagaagatca atgatcaccg ggctgtgggc atggctatct acaatgtggc   2520

agtcctgtgc ctcatcactg ctcctgtcac catgattctg tccagccagc aggatgcagc   2580

ctttgccttt gcctctcttg ccatagtttt ctcctcctat atcactcttg ttgtgctctt   2640

tgtgcccaag atgcgcaggc tgatcacccg aggggaatgg cagtcggagg cgcaggacac   2700

catgaagaca gggtcatcga ccaacaacaa cgaggaggag aagtcccggc tgttggagaa   2760

ggagaaccgt gaactggaaa agatcattgc tgagaaagag gagcgtgtct ctgaactgcg   2820

ccatcaactc cagtctcggc agcagctccg ctcccggcgc cacccaccga cacccccaga   2880

accctctggg ggcctgccca ggggaccccc tgagcccccc gaccggctta gctgtgatgg   2940

gagtcgagtg catttgcttt ataagtgagg gtagggtgag ggaggacagg ccagtagggg   3000

gagggaaagg gagaggggaa gggcagggga ctcaggaagc agggggtccc catccccagc   3060

tgggaagaac atgctatcca atctcatctc ttgtaaatac atgtccccct gtgagttctg   3120

ggctgatttg ggtctctcat acctctggga aacagacctt tttctctctt actgcttcat   3180

gtaattttgt atcacctctt cacaatttag ttcgtacctg gcttgaagct gctcactgct   3240

cacacgctgc ctcctcagca gcctcactgc atctttctct tcccatgcaa caccctcttc   3300

tagttaccac ggcaacccct gcagctcctc tgcctttgtg ctctgttcct gtccagcagg   3360

ggtctcccaa caagtgctct ttccacccca aaggggcctc tccttttctc cactgtcata   3420

atctctttcc atcttacttg cccttctata ctttctcaca tgtggctccc cctgaatttt   3480

gcttcctttg ggagctcatt cttttcgcca aggctcacat gctccttgcc tctgctctgt   3540

gcactcacgc tcagcacaca tgcatcctcc cctctcctgc gtgtgcccac tgaacatgct   3600

catgtgtaca cacgcttttc ccgtatgctt tcttcatgtt cagtcacatg tgctctcggg   3660

tgccctgcat tcacagctac gtgtgcccct ctcatggtca tgggtctgcc cttgagcgtg   3720

tttgggtagg catgtgcaat ttgtctagca tgctgagtca tgtctttcct atttgcacac   3780

gtccatgttt atccatgtac tttccctgtg taccctccat gtaccttgtg tactttcttc   3840

ccttaaatca tggtattctt ctgacagagc catatgtacc ctaccctgca cattgttatg   3900

cacttttccc caattcatgt ttggtggggc catccacacc ctctccttgt cacagaatct   3960

ccatttctgc tcagattccc cccatctcca ttgcattcat gtactaccct cagtctacac   4020

tcacaatcat cttctcccaa gactgctccc ttttgttttg tgtttttttg aggggaatta   4080

aggaaaaata agtgggggca ggtttggaga gctgcttcca gtggatagtt gatgagaatc   4140

ctgaccaaag gaaggcaccc ttgactgttg ggatagacag atggacctat ggggtgggag   4200

gtggtgtccc tttcacactg tggtgtctct tggggaagga tctccccgaa tctcaataaa   4260

ccagtgaaca gtgtgactcg gcaaaaaaaa aaaa                               4294


<210>  404
<211>  578
<212>  PRT
<213>  Homosapiens

<400>  404

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Ser Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Val Ile Ser Arg Thr His Ser 
                565                 570                 575     


Pro Thr 
        


<210>  405
<211>  4445
<212>  DNA
<213>  Homosapiens

<400>  405
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgt tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtccgaat ctgctccaag    540

tcttatttga ccctggaaaa tgggaaggtt ttcctgacgg gtggggacct cccagctctg    600

gacggagccc gggtggattt ccggtgtgac cccgacttcc atctggtggg cagctcccgg    660

agcatctgta gtcagggcca gtggagcacc cccaagcccc actgccaggt gaatcgaacg    720

ccacactcag aacggcgcgc agtgtacatc ggggcactgt ttcccatgag cgggggctgg    780

ccagggggcc aggcctgcca gcccgcggtg gagatggcgc tggaggacgt gaatagccgc    840

agggacatcc tgccggacta tgagctcaag ctcatccacc acgacagcaa gtgtgatcca    900

ggccaagcca ccaagtacct atatgagctg ctctacaacg accctatcaa gatcatcctt    960

atgcctggct gcagctctgt ctccacgctg gtggctgagg ctgctaggat gtggaacctc   1020

attgtgcttt cctatggctc cagctcacca gccctgtcaa accggcagcg tttccccact   1080

ttcttccgaa cgcacccatc agccacactc cacaacccta cccgcgtgaa actctttgaa   1140

aagtggggct ggaagaagat tgctaccatc cagcagacca ctgaggtctt cacttcgact   1200

ctggacgacc tggaggaacg agtgaaggag gctggaattg agattacttt ccgccagagt   1260

ttcttctcag atccagctgt gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc   1320

gtgggacttt tctatgagac tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt   1380

ctctttggga agaagtacgt ctggttcctc attgggtggt atgctgacaa ttggttcaag   1440

atctacgacc cttctatcaa ctgcacagtg gatgagatga ctgaggcggt ggagggccac   1500

atcacaactg agattgtcat gctgaatcct gccaataccc gcagcatttc caacatgaca   1560

tcccaggaat ttgtggagaa actaaccaag cgactgaaaa gacaccctga ggagacagga   1620

ggcttccagg aggcaccgct ggcctatgat gccatctggg ccttggcact ggccctgaac   1680

aagacatctg gaggaggcgg ccgttctggt gtgcgcctgg aggacttcaa ctacaacaac   1740

cagaccatta ccgaccaaat ctaccgggca atgaactctt cgtcctttga gggtgtctct   1800

ggccatgtgg tgtttgatgc cagcggctct cggatggcat ggacgcttat cgagcagctt   1860

cagggtggca gctacaagaa gattggctac tatgacagca ccaaggatga tctttcctgg   1920

tccaaaacag ataaatggat tggagggtcc cccccagctg accagaccct ggtcatcaag   1980

acattccgct tcctgtcaca gaaactcttt atctccgtct cagttctctc cagcctgggc   2040

attgtcctag ctgttgtctg tctgtccttt aacatctaca actcacatgt ccgttatatc   2100

cagaactcac agcccaacct gaacaacctg actgctgtgg gctgctcact ggctttagct   2160

gctgtcttcc ccctggggct cgatggttac cacattggga ggaaccagtt tcctttcgtc   2220

tgccaggccc gcctctggct cctgggcctg ggctttagtc tgggctacgg ttccatgttc   2280

accaagattt ggtgggtcca cacggtcttc acaaagaagg aagaaaagaa ggagtggagg   2340

aagactctgg aaccctggaa gctgtatgcc acagtgggcc tgctggtggg catggatgtc   2400

ctcactctcg ccatctggca gatcgtggac cctctgcacc ggaccattga gacatttgcc   2460

aaggaggaac ctaaggaaga tattgacgtc tctattctgc cccagctgga gcattgcagc   2520

tccaggaaga tgaatacatg gcttggcatt ttctatggtt acaaggggct gctgctgctg   2580

ctgggaatct tccttgctta tgagaccaag agtgtgtcca ctgagaagat caatgatcac   2640

cgggctgtgg gcatggctat ctacaatgtg gcagtcctgt gcctcatcac tgctcctgtc   2700

accatgattc tgtccagcca gcaggatgca gcctttgcct ttgcctctct tgccatagtt   2760

ttctcctcct atatcactct tgttgtgctc tttgtgccca agatgcgcag gctgatcacc   2820

cgaggggaat ggcagtcgga ggcgcaggac accatgaaga cagggtcatc gaccaacaac   2880

aacgaggagg agaagtcccg gctgttggag aaggagaacc gtgaactgga aaagatcatt   2940

gctgagaaag aggagcgtgt ctctgaactg cgccatcaac tccagtctcg gcagcagctc   3000

cgctcccggc gccacccacc gacaccccca gaaccctctg ggggcctgcc caggggaccc   3060

cctgagcccc ccgaccggct tagctgtgat gggagtcgag tgcatttgct ttataagtga   3120

gggtagggtg agggaggaca ggccagtagg gggagggaaa gggagagggg aagggcaggg   3180

gactcaggaa gcagggggtc cccatcccca gctgggaaga acatgctatc caatctcatc   3240

tcttgtaaat acatgtcccc ctgtgagttc tgggctgatt tgggtctctc atacctctgg   3300

gaaacagacc tttttctctc ttactgcttc atgtaatttt gtatcacctc ttcacaattt   3360

agttcgtacc tggcttgaag ctgctcactg ctcacacgct gcctcctcag cagcctcact   3420

gcatctttct cttcccatgc aacaccctct tctagttacc acggcaaccc ctgcagctcc   3480

tctgcctttg tgctctgttc ctgtccagca ggggtctccc aacaagtgct ctttccaccc   3540

caaaggggcc tctccttttc tccactgtca taatctcttt ccatcttact tgcccttcta   3600

tactttctca catgtggctc cccctgaatt ttgcttcctt tgggagctca ttcttttcgc   3660

caaggctcac atgctccttg cctctgctct gtgcactcac gctcagcaca catgcatcct   3720

cccctctcct gcgtgtgccc actgaacatg ctcatgtgta cacacgcttt tcccgtatgc   3780

tttcttcatg ttcagtcaca tgtgctctcg ggtgccctgc attcacagct acgtgtgccc   3840

ctctcatggt catgggtctg cccttgagcg tgtttgggta ggcatgtgca atttgtctag   3900

catgctgagt catgtctttc ctatttgcac acgtccatgt ttatccatgt actttccctg   3960

tgtaccctcc atgtaccttg tgtactttct tcccttaaat catggtattc ttctgacaga   4020

gccatatgta ccctaccctg cacattgtta tgcacttttc cccaattcat gtttggtggg   4080

gccatccaca ccctctcctt gtcacagaat ctccatttct gctcagattc cccccatctc   4140

cattgcattc atgtactacc ctcagtctac actcacaatc atcttctccc aagactgctc   4200

ccttttgttt tgtgtttttt tgaggggaat taaggaaaaa taagtggggg caggtttgga   4260

gagctgcttc cagtggatag ttgatgagaa tcctgaccaa aggaaggcac ccttgactgt   4320

tgggatagac agatggacct atggggtggg aggtggtgtc cctttcacac tgtggtgtct   4380

cttggggaag gatctccccg aatctcaata aaccagtgaa cagtgtgact cggcaaaaaa   4440

aaaaa                                                               4445


<210>  406
<211>  961
<212>  PRT
<213>  Homosapiens

<400>  406

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575     


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590         


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605             


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620                 


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640 


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655     


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670         


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685             


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700                 


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720 


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735     


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750         


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765             


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780                 


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800 


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815     


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830         


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845             


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860                 


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880 


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895     


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910         


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925             


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940                 


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960 


Lys 
    


<210>  407
<211>  4260
<212>  DNA
<213>  Homosapiens

<400>  407
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgc tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcatacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtgaatcg aacgccacac    540

tcagaacggc gcgcagtgta catcggggca ctgtttccca tgagcggggg ctggccaggg    600

ggccaggcct gccagcccgc ggtggagatg gcgctggagg acgtgaatag ccgcagggac    660

atcctgccgg actatgagct caagctcatc caccacgaca gcaagtgtga tccaggccaa    720

gccaccaagt acctatatga gctgctctac aacgacccta tcaagatcat ccttatgcct    780

ggctgcagct ctgtctccac gctggtggct gaggctgcta ggatgtggaa cctcattgtg    840

ctttcctatg gctccagctc accagccctg tcaaaccggc agcgtttccc cactttcttc    900

cgaacgcacc catcagccac actccacaac cctacccgcg tgaaactctt tgaaaagtgg    960

ggctggaaga agattgctac catccagcag accactgagg tcttcacttc gactctggac   1020

gacctggagg aacgagtgaa ggaggctgga attgagatta ctttccgcca gagtttcttc   1080

tcagatccag ctgtgcccgt caaaaacctg aagcgccagg atgcccgaat catcgtggga   1140

cttttctatg agactgaagc ccggaaagtt ttttgtgagg tgtacaagga gcgtctcttt   1200

gggaagaagt acgtctggtt cctcattggg tggtatgctg acaattggtt caagatctac   1260

gacccttcta tcaactgcac agtggatgag atgactgagg cggtggaggg ccacatcaca   1320

actgagattg tcatgctgaa tcctgccaat acccgcagca tttccaacat gacatcccag   1380

gaatttgtgg agaaactaac caagcgactg aaaagacacc ctgaggagac aggaggcttc   1440

caggaggcac cgctggccta tgatgccatc tgggccttgg cactggccct gaacaagaca   1500

tctggaggag gcggccgttc tggtgtgcgc ctggaggact tcaactacaa caaccagacc   1560

attaccgacc aaatctaccg ggcaatgaac tcttcgtcct ttgagggtgt ctctggccat   1620

gtggtgtttg atgccagcgg ctctcggatg gcatggacgc ttatcgagca gcttcagggt   1680

ggcagctaca agaagattgg ctactatgac agcaccaagg atgatctttc ctggtccaaa   1740

acagataaat ggattggagg gtccccccca gctgaccaga ccctggtcat caagacattc   1800

cgcttcctgt cacagaaact ctttatctcc gtctcagttc tctccagcct gggcattgtc   1860

ctagctgttg tctgtctgtc ctttaacatc tacaactcac atgtccgtta tatccagaac   1920

tcacagccca acctgaacaa cctgactgct gtgggctgct cactggcttt agctgctgtc   1980

ttccccctgg ggctcgatgg ttaccacatt gggaggaacc agtttccttt cgtctgccag   2040

gcccgcctct ggctcctggg cctgggcttt agtctgggct acggttccat gttcaccaag   2100

atttggtggg tccacacggt cttcacaaag aaggaagaaa agaaggagtg gaggaagact   2160

ctggaaccct ggaagctgta tgccacagtg ggcctgctgg tgggcatgga tgtcctcact   2220

ctcgccatct ggcagatcgt ggaccctctg caccggacca ttgagacatt tgccaaggag   2280

gaacctaagg aagatattga cgtctctatt ctgccccagc tggagcattg cagctccagg   2340

aagatgaata catggcttgg cattttctat ggttacaagg ggctgctgct gctgctggga   2400

atcttccttg cttatgagac caagagtgtg tccactgaga agatcaatga tcaccgggct   2460

gtgggcatgg ctatctacaa tgtggcagtc ctgtgcctca tcactgctcc tgtcaccatg   2520

attctgtcca gccagcagga tgcagccttt gcctttgcct ctcttgccat agttttctcc   2580

tcctatatca ctcttgttgt gctctttgtg cccaagatgc gcaggctgat cacccgaggg   2640

gaatggcagt cggaggcgca ggacaccatg aagacagggt catcgaccaa caacaacgag   2700

gaggagaagt cccggctgtt ggagaaggag aaccgtgaac tggaaaagat cattgctgag   2760

aaagaggagc gtgtctctga actgcgccat caactccagt ctcggcagca gctccgctcc   2820

cggcgccacc caccgacacc cccagaaccc tctgggggcc tgcccagggg accccctgag   2880

ccccccgacc ggcttagctg tgatgggagt cgagtgcatt tgctttataa gtgagggtag   2940

ggtgagggag gacaggccag tagggggagg gaaagggaga ggggaagggc aggggactca   3000

ggaagcaggg ggtccccatc cccagctggg aagaacatgc tatccaatct catctcttgt   3060

aaatacatgt ccccctgtga gttctgggct gatttgggtc tctcatacct ctgggaaaca   3120

gacctttttc tctcttactg cttcatgtaa ttttgtatca cctcttcaca atttagttcg   3180

tacctggctt gaagctgctc actgctcaca cgctgcctcc tcagcagcct cactgcatct   3240

ttctcttccc atgcaacacc ctcttctagt taccacggca acccctgcag ctcctctgcc   3300

tttgtgctct gttcctgtcc agcaggggtc tcccaacaag tgctctttcc accccaaagg   3360

ggcctctcct tttctccact gtcataatct ctttccatct tacttgccct tctatacttt   3420

ctcacatgtg gctccccctg aattttgctt cctttgggag ctcattcttt tcgccaaggc   3480

tcacatgctc cttgcctctg ctctgtgcac tcacgctcag cacacatgca tcctcccctc   3540

tcctgcgtgt gcccactgaa catgctcatg tgtacacacg cttttcccgt atgctttctt   3600

catgttcagt cacatgtgct ctcgggtgcc ctgcattcac agctacgtgt gcccctctca   3660

tggtcatggg tctgcccttg agcgtgtttg ggtaggcatg tgcaatttgt ctagcatgct   3720

gagtcatgtc tttcctattt gcacacgtcc atgtttatcc atgtactttc cctgtgtacc   3780

ctccatgtac cttgtgtact ttcttccctt aaatcatggt attcttctga cagagccata   3840

tgtaccctac cctgcacatt gttatgcact tttccccaat tcatgtttgg tggggccatc   3900

cacaccctct ccttgtcaca gaatctccat ttctgctcag attcccccca tctccattgc   3960

attcatgtac taccctcagt ctacactcac aatcatcttc tcccaagact gctccctttt   4020

gttttgtgtt tttttgaggg gaattaagga aaaataagtg ggggcaggtt tggagagctg   4080

cttccagtgg atagttgatg agaatcctga ccaaaggaag gcacccttga ctgttgggat   4140

agacagatgg acctatgggg tgggaggtgg tgtccctttc acactgtggt gtctcttggg   4200

gaaggatctc cccgaatctc aataaaccag tgaacagtgt gactcggcaa aaaaaaaaaa   4260


<210>  408
<211>  899
<212>  PRT
<213>  Homosapiens

<400>  408

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala His Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110         


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125             


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140                 


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160 


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175     


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190         


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205             


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220                 


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240 


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255     


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270         


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285             


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300                 


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320 


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335     


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350         


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365             


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380                 


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400 


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415     


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430         


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445             


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460                 


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480 


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495     


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510         


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525             


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540                 


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560 


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575     


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590         


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605             


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620                 


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640 


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655     


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670         


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685             


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700                 


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735     


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750         


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765             


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780                 


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800 


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815     


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830         


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845             


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860                 


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880 


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895     


Leu Tyr Lys 
            


<210>  409
<211>  1869
<212>  DNA
<213>  Homosapiens

<400>  409
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    780

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt    840

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga    900

agagctactc ttccacctgg aagccctctc tggctaagga caggcaggtg cccctctctc    960

catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg aactggaggc   1020

caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg ttgtttcttc   1080

caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg aagaggaaga   1140

gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga gtagccccaa   1200

cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct ccttgtcttg   1260

gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc ctgctttaga   1320

atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt cctctcatcc   1380

ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac tactacttga   1440

tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt tttggccggg   1500

tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc gaatcacgag   1560

gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca   1620

aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg aggctgaggc   1680

aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg tgccactgca   1740

ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa ataaataaat   1800

aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca cacttctaaa   1860

aaaaaaaaa                                                           1869


<210>  410
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  410

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250         


<210>  411
<211>  2050
<212>  DNA
<213>  Homosapiens

<400>  411
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg agtcctttgg    780

tgttctagga ccccaggtta aggaaccaaa aaagacaggg caattccttg aagagctacg    840

aaatcccttc tgagtgatgt cacatcttgg caggggtgga ggagagcctg gttgcccagg    900

gatttgtcct tggggacatc tcatccatca agttgcacac tcactggcat ctttgctatg    960

gggacattcc aatttgcact ttcaggaaca ctctgaattc caagtagaat tgatttccct   1020

tcttctgtca tctacctttt ctcttcattt tcccattttt attacccttc tttccatttc   1080

tctctccagt cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct   1140

ccatcagagg acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg   1200

ccaggaatct cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt   1260

ccaagactcc agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag   1320

agtgcaaaac attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca   1380

acccaaacct ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt   1440

ggcagcctac tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag   1500

aatgttttcc ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc   1560

cttttctcct atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg   1620

atggtcagac acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg   1680

gtgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga   1740

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac   1800

aaacaattaa ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg   1860

caggagaatc gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc   1920

actctagccg gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa   1980

taaataaata aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa   2040

aaaaaaaaaa                                                          2050


<210>  412
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  412

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220                 


<210>  413
<211>  1731
<212>  DNA
<213>  Homosapiens

<400>  413
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg tcttccacct    780

ggaagccctc tctggctaag gacaggcagg tgcccctctc tccatcagag gacacctgta    840

ctggagagca acacaggatg gtctctgcca tgaactggag gccaggaatc tcctcactga    900

aaattacagt atggtaactt tgcaaatggt ggttgtttct tccaagactc cagccctgat    960

tgcgcaaaac tgaaaggcat gtgaagggaa ggaagaggaa gagtgcaaaa cattgaagag   1020

agagctgagt gagctgaaga gtgaggatat gagtagcccc aacccaaacc tggagatggg   1080

gagaaaccta cagaatacta gccagagctc ctccttgtct tggcagccta ctagggacct   1140

ggggaagcaa aaacgaaagc tgggcaacat gcctgcttta gaatgttttc cttctactta   1200

cacatcttcc acaggtctca gaatctttcc ttcctctcat ccttttctcc tatcttcata   1260

tctatcagag tatccactgt ttattcaaca actactactt gatggtcaga cacaaacaaa   1320

caagctaggt gctaattaat aaagatacga gttttggccg ggtgcggtgg ctcacgcctg   1380

taatcccagc actttgggag gccgaggcgg gcgaatcacg aggtcaggag ttcaagacca   1440

gcctggccaa catggtgaaa ccccatctct actaaaaata caaacaatta actgagcata   1500

gtggtgggca cctataatac cagctactcc ggaggctgag gcaggagaat cgcttgaacc   1560

caggaggcag aggttgcagt gagctgagat cgtgccactg cactctagcc ggagtgacag   1620

agtaagactc tgtctcaaaa ataaataaat aaataaataa ataaataaat aaataaataa   1680

ataaaaaata ataatacaag ttttcataag cacacttcta aaaaaaaaaa a            1731


<210>  414
<211>  206
<212>  PRT
<213>  Homosapiens

<400>  414

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205     


<210>  415
<211>  2119
<212>  DNA
<213>  Homosapiens

<400>  415
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    780

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt    840

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga    900

agagctacga aatcccttct gagtgatgtc acatcttggc aggggtggag gagagcctgg    960

ttgcccaggg atttgtcctt ggggacatct catccatcaa gttgcacact cactggcatc   1020

tttgctatgg ggacattcca atttgcactt tcaggaacac tctgaattcc aagtagaatt   1080

gatttccctt cttctgtcat ctaccttttc tcttcatttt cccattttta ttacccttct   1140

ttccatttct ctctccagtc ttccacctgg aagccctctc tggctaagga caggcaggtg   1200

cccctctctc catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg   1260

aactggaggc caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg   1320

ttgtttcttc caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg   1380

aagaggaaga gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga   1440

gtagccccaa cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct   1500

ccttgtcttg gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc   1560

ctgctttaga atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt   1620

cctctcatcc ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac   1680

tactacttga tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt   1740

tttggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc   1800

gaatcacgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac   1860

taaaaataca aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg   1920

aggctgaggc aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg   1980

tgccactgca ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa   2040

ataaataaat aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca   2100

cacttctaaa aaaaaaaaa                                                2119


<210>  416
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  416

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  417
<211>  1752
<212>  DNA
<213>  Homosapiens

<400>  417
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg ggcaattcct    780

tgaagagcta ctcttccacc tggaagccct ctctggctaa ggacaggcag gtgcccctct    840

ctccatcaga ggacacctgt actggagagc aacacaggat ggtctctgcc atgaactgga    900

ggccaggaat ctcctcactg aaaattacag tatggtaact ttgcaaatgg tggttgtttc    960

ttccaagact ccagccctga ttgcgcaaaa ctgaaaggca tgtgaaggga aggaagagga   1020

agagtgcaaa acattgaaga gagagctgag tgagctgaag agtgaggata tgagtagccc   1080

caacccaaac ctggagatgg ggagaaacct acagaatact agccagagct cctccttgtc   1140

ttggcagcct actagggacc tggggaagca aaaacgaaag ctgggcaaca tgcctgcttt   1200

agaatgtttt ccttctactt acacatcttc cacaggtctc agaatctttc cttcctctca   1260

tccttttctc ctatcttcat atctatcaga gtatccactg tttattcaac aactactact   1320

tgatggtcag acacaaacaa acaagctagg tgctaattaa taaagatacg agttttggcc   1380

gggtgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcgaatcac   1440

gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc tactaaaaat   1500

acaaacaatt aactgagcat agtggtgggc acctataata ccagctactc cggaggctga   1560

ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagctgaga tcgtgccact   1620

gcactctagc cggagtgaca gagtaagact ctgtctcaaa aataaataaa taaataaata   1680

aataaataaa taaataaata aataaaaaat aataatacaa gttttcataa gcacacttct   1740

aaaaaaaaaa aa                                                       1752


<210>  418
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  418

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
        195                 200                 205             


Glu Ala Leu Ser Gly 
    210             


<210>  419
<211>  2002
<212>  DNA
<213>  Homosapiens

<400>  419
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg ggcaattcct    780

tgaagagcta cgaaatccct tctgagtgat gtcacatctt ggcaggggtg gaggagagcc    840

tggttgccca gggatttgtc cttggggaca tctcatccat caagttgcac actcactggc    900

atctttgcta tggggacatt ccaatttgca ctttcaggaa cactctgaat tccaagtaga    960

attgatttcc cttcttctgt catctacctt ttctcttcat tttcccattt ttattaccct   1020

tctttccatt tctctctcca gtcttccacc tggaagccct ctctggctaa ggacaggcag   1080

gtgcccctct ctccatcaga ggacacctgt actggagagc aacacaggat ggtctctgcc   1140

atgaactgga ggccaggaat ctcctcactg aaaattacag tatggtaact ttgcaaatgg   1200

tggttgtttc ttccaagact ccagccctga ttgcgcaaaa ctgaaaggca tgtgaaggga   1260

aggaagagga agagtgcaaa acattgaaga gagagctgag tgagctgaag agtgaggata   1320

tgagtagccc caacccaaac ctggagatgg ggagaaacct acagaatact agccagagct   1380

cctccttgtc ttggcagcct actagggacc tggggaagca aaaacgaaag ctgggcaaca   1440

tgcctgcttt agaatgtttt ccttctactt acacatcttc cacaggtctc agaatctttc   1500

cttcctctca tccttttctc ctatcttcat atctatcaga gtatccactg tttattcaac   1560

aactactact tgatggtcag acacaaacaa acaagctagg tgctaattaa taaagatacg   1620

agttttggcc gggtgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg   1680

ggcgaatcac gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc   1740

tactaaaaat acaaacaatt aactgagcat agtggtgggc acctataata ccagctactc   1800

cggaggctga ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagctgaga   1860

tcgtgccact gcactctagc cggagtgaca gagtaagact ctgtctcaaa aataaataaa   1920

taaataaata aataaataaa taaataaata aataaaaaat aataatacaa gttttcataa   1980

gcacacttct aaaaaaaaaa aa                                            2002


<210>  420
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  420

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
        195                 200                 205             


<210>  421
<211>  1800
<212>  DNA
<213>  Homosapiens

<400>  421
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg agtcctttgg    780

tgttctagga ccccaggtta aggaaccaaa aaagacaggg caattccttg aagagctact    840

cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct ccatcagagg    900

acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg ccaggaatct    960

cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt ccaagactcc   1020

agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag agtgcaaaac   1080

attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca acccaaacct   1140

ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt ggcagcctac   1200

tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag aatgttttcc   1260

ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc cttttctcct   1320

atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg atggtcagac   1380

acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg gtgcggtggc   1440

tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga ggtcaggagt   1500

tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaacaattaa   1560

ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg caggagaatc   1620

gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc actctagccg   1680

gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa taaataaata   1740

aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa aaaaaaaaaa   1800


<210>  422
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  422

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
    210                 215                 220                 


Glu Ala Leu Ser Gly 
225                 


<210>  423
<211>  2007
<212>  DNA
<213>  Homosapiens

<400>  423
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagtgtctc actctgtgac ccaggattgg ttgcagtggc acgatcatgg    660

ctcattgcag cctccacctc ccaggctcaa gtgatcctcc tgactcagcc tcttgaatag    720

ctgagaccac aggcttgtgt caccatgccc agatcctttc tactgggtga gccctggagt    780

gctggttctc ctcgcggtgc tgcctgtgct cctcctgcag atcactgttg gcctcatctt    840

cctctgcctg cagtacagac tgagaggaaa acttcgagca gagatagaga atctccaccg    900

gacttttgat ccccactttc tgagggtgcc ctgctggaag ataaccctgt ttgtaattgt    960

gccggttctt ggacccttgg ttgccttgat catctgctac aactggctac atcgaagact   1020

agcagggcaa ttccttgaag agctactctt ccacctggaa gccctctctg gctaaggaca   1080

ggcaggtgcc cctctctcca tcagaggaca cctgtactgg agagcaacac aggatggtct   1140

ctgccatgaa ctggaggcca ggaatctcct cactgaaaat tacagtatgg taactttgca   1200

aatggtggtt gtttcttcca agactccagc cctgattgcg caaaactgaa aggcatgtga   1260

agggaaggaa gaggaagagt gcaaaacatt gaagagagag ctgagtgagc tgaagagtga   1320

ggatatgagt agccccaacc caaacctgga gatggggaga aacctacaga atactagcca   1380

gagctcctcc ttgtcttggc agcctactag ggacctgggg aagcaaaaac gaaagctggg   1440

caacatgcct gctttagaat gttttccttc tacttacaca tcttccacag gtctcagaat   1500

ctttccttcc tctcatcctt ttctcctatc ttcatatcta tcagagtatc cactgtttat   1560

tcaacaacta ctacttgatg gtcagacaca aacaaacaag ctaggtgcta attaataaag   1620

atacgagttt tggccgggtg cggtggctca cgcctgtaat cccagcactt tgggaggccg   1680

aggcgggcga atcacgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc   1740

atctctacta aaaatacaaa caattaactg agcatagtgg tgggcaccta taataccagc   1800

tactccggag gctgaggcag gagaatcgct tgaacccagg aggcagaggt tgcagtgagc   1860

tgagatcgtg ccactgcact ctagccggag tgacagagta agactctgtc tcaaaaataa   1920

ataaataaat aaataaataa ataaataaat aaataaataa aaaataataa tacaagtttt   1980

cataagcaca cttctaaaaa aaaaaaa                                       2007


<210>  424
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  424

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160 


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170     


<210>  425
<211>  2257
<212>  DNA
<213>  Homosapiens

<400>  425
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagtgtctc actctgtgac ccaggattgg ttgcagtggc acgatcatgg    660

ctcattgcag cctccacctc ccaggctcaa gtgatcctcc tgactcagcc tcttgaatag    720

ctgagaccac aggcttgtgt caccatgccc agatcctttc tactgggtga gccctggagt    780

gctggttctc ctcgcggtgc tgcctgtgct cctcctgcag atcactgttg gcctcatctt    840

cctctgcctg cagtacagac tgagaggaaa acttcgagca gagatagaga atctccaccg    900

gacttttgat ccccactttc tgagggtgcc ctgctggaag ataaccctgt ttgtaattgt    960

gccggttctt ggacccttgg ttgccttgat catctgctac aactggctac atcgaagact   1020

agcagggcaa ttccttgaag agctacgaaa tcccttctga gtgatgtcac atcttggcag   1080

gggtggagga gagcctggtt gcccagggat ttgtccttgg ggacatctca tccatcaagt   1140

tgcacactca ctggcatctt tgctatgggg acattccaat ttgcactttc aggaacactc   1200

tgaattccaa gtagaattga tttcccttct tctgtcatct accttttctc ttcattttcc   1260

catttttatt acccttcttt ccatttctct ctccagtctt ccacctggaa gccctctctg   1320

gctaaggaca ggcaggtgcc cctctctcca tcagaggaca cctgtactgg agagcaacac   1380

aggatggtct ctgccatgaa ctggaggcca ggaatctcct cactgaaaat tacagtatgg   1440

taactttgca aatggtggtt gtttcttcca agactccagc cctgattgcg caaaactgaa   1500

aggcatgtga agggaaggaa gaggaagagt gcaaaacatt gaagagagag ctgagtgagc   1560

tgaagagtga ggatatgagt agccccaacc caaacctgga gatggggaga aacctacaga   1620

atactagcca gagctcctcc ttgtcttggc agcctactag ggacctgggg aagcaaaaac   1680

gaaagctggg caacatgcct gctttagaat gttttccttc tacttacaca tcttccacag   1740

gtctcagaat ctttccttcc tctcatcctt ttctcctatc ttcatatcta tcagagtatc   1800

cactgtttat tcaacaacta ctacttgatg gtcagacaca aacaaacaag ctaggtgcta   1860

attaataaag atacgagttt tggccgggtg cggtggctca cgcctgtaat cccagcactt   1920

tgggaggccg aggcgggcga atcacgaggt caggagttca agaccagcct ggccaacatg   1980

gtgaaacccc atctctacta aaaatacaaa caattaactg agcatagtgg tgggcaccta   2040

taataccagc tactccggag gctgaggcag gagaatcgct tgaacccagg aggcagaggt   2100

tgcagtgagc tgagatcgtg ccactgcact ctagccggag tgacagagta agactctgtc   2160

tcaaaaataa ataaataaat aaataaataa ataaataaat aaataaataa aaaataataa   2220

tacaagtttt cataagcaca cttctaaaaa aaaaaaa                            2257


<210>  426
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  426

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160 


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170     


<210>  427
<211>  1976
<212>  DNA
<213>  Homosapiens

<400>  427
tccccgggag accctgtgcc cctaaatcgc ggtccactgc gcgcgtcagg tttctagaag     60

cagggtagaa cagacggcag acacctagcc caggctggtg ttgttactaa acaatggcag    120

ctggtgagcc aagggtgacc agggccctga actcggtggc ccagctttga gggaagcaaa    180

attgttctca attgtggaag aggagaattt ggacagcaga acaaaaaagg aagacagcct    240

cttggagcag atacatttgt cacaggaagc cacatcaaac cctggggcct ttgctgggcc    300

tctccatctg cccagttact gggaggtaga tagccccagg aaggaatcca gtcaggcctg    360

ggcaccaggc caggagtgga taaagctaga aagagacacc acagaagaga agatgtttga    420

acagctgaag ccatgaagag agattgctgg agggaggcac gggtgaagaa gaagccagtc    480

acctttgagg atgtggcagt gaatttcacc caggaagagt gggactgtct agatgccagc    540

cagagggtcc tttaccagga tgttatgtcg gaaaccttta agaatctaac atctgtggcc    600

agaatctttc tgcataagcc agagctaatc accaagcttg agcaagaaga ggaacagtgg    660

agagagtttg tccatctccc aaacacagaa ggcctttcag aaggcaagaa gaaagagctt    720

cgagaacaac atcccagtct gagagatgag gggactagtg atgacaaggt cttccttgca    780

tgcagagggg ccggccagtg ccccctatct gccccagctg ggactatgga caggacccgg    840

gtgcttcaag catcccaggc tgggccaccc tttttttgct acacctgtgg caaatgtttc    900

agcaggcgct cctacctcta tagccaccag tttgttcaca atcccaagct gactaacagc    960

tgcagtcagt gtgggaagtt gtttcggagc cccaagtccc tcagctatca cagacgcatg   1020

catcttgggg agaggccctt ctgttgcacg ctctgtgaca agacctactg tgatgcttct   1080

ggactaagtc gtcaccgccg cgtccatctg ggttaccggc cccattcatg ctctgtgtgt   1140

gggaagagct tccgggacca gtctgagctc aaacgccacc agaagataca ccaaaaccag   1200

gagccagtgg atggaaacca ggagtgtact ttgaggattc caggcaccca ggctgaattc   1260

cagacaccca tcgccagaag ccagaggtcc atccaggggc ttttggatgt gaaccatgca   1320

ccagtggcca ggtcccagga acccatattt agaactgagg gtcctatggc ccagaaccag   1380

gcatctgtac ttaagaacca agcacctgtg accaggaccc aggcacccat cactggaacc   1440

ctctgtcagg atgccagatc caactctcat ccagtgaagc cctcaagact caatgtcttc   1500

tgttgccccc attgttcttt gacttttagc aagaaatcct atctctccag acaccagaag   1560

gcccacctca cagagccgcc caactactgc ttccattgca gcaagtcttt cagctcattt   1620

tccaggctgg tcagacacca gcagacccac tggaagcaga agagctacct ttgccctatc   1680

tgtgacctct cctttgggga gaaagagggc cttatggatc actggagggg ctataaaggc   1740

aaggacctgt gccagagcag ccaccataaa tgccgggtga tcctgggcca gtggcttggc   1800

ttctctcatg atgtccccac tatggctggg gaggaatgga agcatggagg tgatcaatct   1860

ccccccagga tccatacccc caggagaaga ggcctaagag agaaggcctg caaaggagac   1920

aaaacaaagg aggcagtgag catcttgaaa cataaataaa tggcctttct gactga       1976


<210>  428
<211>  508
<212>  PRT
<213>  Homosapiens

<400>  428

Met Lys Arg Asp Cys Trp Arg Glu Ala Arg Val Lys Lys Lys Pro Val 
1               5                   10                  15      


Thr Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu Glu Trp Asp Cys 
            20                  25                  30          


Leu Asp Ala Ser Gln Arg Val Leu Tyr Gln Asp Val Met Ser Glu Thr 
        35                  40                  45              


Phe Lys Asn Leu Thr Ser Val Ala Arg Ile Phe Leu His Lys Pro Glu 
    50                  55                  60                  


Leu Ile Thr Lys Leu Glu Gln Glu Glu Glu Gln Trp Arg Glu Phe Val 
65                  70                  75                  80  


His Leu Pro Asn Thr Glu Gly Leu Ser Glu Gly Lys Lys Lys Glu Leu 
                85                  90                  95      


Arg Glu Gln His Pro Ser Leu Arg Asp Glu Gly Thr Ser Asp Asp Lys 
            100                 105                 110         


Val Phe Leu Ala Cys Arg Gly Ala Gly Gln Cys Pro Leu Ser Ala Pro 
        115                 120                 125             


Ala Gly Thr Met Asp Arg Thr Arg Val Leu Gln Ala Ser Gln Ala Gly 
    130                 135                 140                 


Pro Pro Phe Phe Cys Tyr Thr Cys Gly Lys Cys Phe Ser Arg Arg Ser 
145                 150                 155                 160 


Tyr Leu Tyr Ser His Gln Phe Val His Asn Pro Lys Leu Thr Asn Ser 
                165                 170                 175     


Cys Ser Gln Cys Gly Lys Leu Phe Arg Ser Pro Lys Ser Leu Ser Tyr 
            180                 185                 190         


His Arg Arg Met His Leu Gly Glu Arg Pro Phe Cys Cys Thr Leu Cys 
        195                 200                 205             


Asp Lys Thr Tyr Cys Asp Ala Ser Gly Leu Ser Arg His Arg Arg Val 
    210                 215                 220                 


His Leu Gly Tyr Arg Pro His Ser Cys Ser Val Cys Gly Lys Ser Phe 
225                 230                 235                 240 


Arg Asp Gln Ser Glu Leu Lys Arg His Gln Lys Ile His Gln Asn Gln 
                245                 250                 255     


Glu Pro Val Asp Gly Asn Gln Glu Cys Thr Leu Arg Ile Pro Gly Thr 
            260                 265                 270         


Gln Ala Glu Phe Gln Thr Pro Ile Ala Arg Ser Gln Arg Ser Ile Gln 
        275                 280                 285             


Gly Leu Leu Asp Val Asn His Ala Pro Val Ala Arg Ser Gln Glu Pro 
    290                 295                 300                 


Ile Phe Arg Thr Glu Gly Pro Met Ala Gln Asn Gln Ala Ser Val Leu 
305                 310                 315                 320 


Lys Asn Gln Ala Pro Val Thr Arg Thr Gln Ala Pro Ile Thr Gly Thr 
                325                 330                 335     


Leu Cys Gln Asp Ala Arg Ser Asn Ser His Pro Val Lys Pro Ser Arg 
            340                 345                 350         


Leu Asn Val Phe Cys Cys Pro His Cys Ser Leu Thr Phe Ser Lys Lys 
        355                 360                 365             


Ser Tyr Leu Ser Arg His Gln Lys Ala His Leu Thr Glu Pro Pro Asn 
    370                 375                 380                 


Tyr Cys Phe His Cys Ser Lys Ser Phe Ser Ser Phe Ser Arg Leu Val 
385                 390                 395                 400 


Arg His Gln Gln Thr His Trp Lys Gln Lys Ser Tyr Leu Cys Pro Ile 
                405                 410                 415     


Cys Asp Leu Ser Phe Gly Glu Lys Glu Gly Leu Met Asp His Trp Arg 
            420                 425                 430         


Gly Tyr Lys Gly Lys Asp Leu Cys Gln Ser Ser His His Lys Cys Arg 
        435                 440                 445             


Val Ile Leu Gly Gln Trp Leu Gly Phe Ser His Asp Val Pro Thr Met 
    450                 455                 460                 


Ala Gly Glu Glu Trp Lys His Gly Gly Asp Gln Ser Pro Pro Arg Ile 
465                 470                 475                 480 


His Thr Pro Arg Arg Arg Gly Leu Arg Glu Lys Ala Cys Lys Gly Asp 
                485                 490                 495     


Lys Thr Lys Glu Ala Val Ser Ile Leu Lys His Lys 
            500                 505             


<210>  429
<211>  1188
<212>  DNA
<213>  Homosapiens

<400>  429
atggcgcccc gaagcctcct cctgctgctc tcaggggccc tggccctgac cgatacttgg     60

gcgggctccc actccttgag gtatttcagc accgctgtgt cgcggcccgg ccgcggggag    120

ccccgctaca tcgccgtgga gtacgtagac gacacgcaat tcctgcggtt cgacagcgac    180

gccgcgattc cgaggatgga gccgcgggag ccgtgggtgg agcaagaggg gccgcagtat    240

tgggagtgga ccacagggta cgccaaggcc aacgcacaga ctgaccgagt ggccctgagg    300

aacctgctcc gccgctacaa ccagagcgag gctgggtctc acaccctcca gggaatgaat    360

ggctgcgaca tggggcccga cggacgcctc ctccgcgggt atcaccagca cgcgtacgac    420

ggcaaggatt acatctccct gaacgaggac ctgcgctcct ggaccgcggc ggacaccgtg    480

gctcagatca cccagcgctt ctatgaggca gaggaatatg cagaggagtt caggacctac    540

ctggagggcg agtgcctgga gttgctccgc agatacttgg agaatgggaa ggagacgcta    600

cagcgcgcag atcctccaaa ggcacacgtt gcccaccacc ccatctctga ccatgaggcc    660

accctgaggt gctgggccct gggcttctac cctgcggaga tcacgctgac ctggcagcgg    720

gatggggagg aacagaccca ggacacagag cttgtggaga ccaggcctgc aggggatgga    780

accttccaga agtgggccgc tgtggtggtg ccttctggag aggaacagag atacacatgc    840

catgtgcagc acgaggggct gccccagccc ctcatcctga gatgggagca gtctccccag    900

cccaccatcc ccatcgtggg catcgttgct ggccttgttg tccttggagc tgtggtcact    960

ggagctgtgg tcgctgctgt gatgtggagg aagaagagct cagatagaaa cagagggagc   1020

tactctcagg ctgcagtcac tgacagtgcc cagggctctg gggtgtctct cacagctaat   1080

aaagtgtgag acagcttcct tgtgtgggac tgagaagcaa gatatcaatg tagcagaatt   1140

gcacttgtgc ctcacgaaca tacataaatt ttaaaaataa agaataaa                1188


<210>  430
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  430

Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     


Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val Thr Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Gly Val Ser Leu Thr Ala Asn Lys Val 
        355                 360         


<210>  431
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  431
gcggccgccg ccctcgccac cccgcctgcc cactcccgcc gccgccccgc tctcgctttc     60

cccccggcct cccctcgccc cttcccctcc cccttcccgg cgcactcggg gggctgggaa    120

cgagctgcca tgtgatgcgc gtcccctccg cgagctttcg gtgacccacg aactgcccac    180

ctcgccggct gccgggaggg ggctgcgagc cgggaagacg cggggaagag gaggcggaaa    240

aggacgcaaa gttctccggc gagcgcattc attcacatag ctcccagttt taacatttcg    300

ccacctactg aagacatcat ttgggaccaa gctgatgagc ccttgaagca cagcagataa    360

gagtgttgct gttgatcatc tttgcctggg aagttgaatg ataaagccag aagaaagcat    420

gctttctgat catttgcagc tgtctgcttc agaaagtgag ggctccagga atgaggagaa    480

tcttcaagaa cttcctcgca ctgtgacatg tctgatccct tgctcccatc cctgcagcat    540

gaacaaggtg gacactcact gacctgtcac aaggttgccc cacaaaactt tggggtccat    600

gtctgaatgg attgccagag ccttctcatc tctcccttcg cccagttccc tgcatcctaa    660

gactcgaagg cagcacagga cctggaaaaa ttacatggtg tgaacggcat gtctgtggat    720

gagaagcctg actcccccat gtatgtgtat gagtccacag tccactgcac caacatcctc    780

ctgggcctca atgaccagcg gaaaaaggat attctctgtg acgtgacttt gatcgtggag    840

aggaaggagt tccgggccca ccgggctgtg ctggccgcat gcagtgaata tttttggcag    900

gcgctggttg gacagacaaa aaatgatttg gtggtcagct tgcctgagga ggtcacagcc    960

aggggctttg ggccgctgtt acagtttgcc tacactgcca agctgttact cagcagagaa   1020

aacatccgcg aggtcatccg ctgtgctgag ttcctgcgca tgcacaacct ggaggactcc   1080

tgcttcagct tcctgcagac ccagctcctg aacagtgagg atggcctgtt tgtgtgccgg   1140

aaggatgctg cgtgccagcg cccacacgag gactgcgaga actctgcagg agaggaggag   1200

gatgaagagg aggagacgat ggattcagag acggccaaga tggcttgccc cagggaccag   1260

atgcttccag agcccatcag ctttgaggcc gccgccatcc ccgtagcaga gaaggaagaa   1320

gccctgctgc ccgagcctga cgtgcccaca gacaccaagg agagctcaga aaaggacgcg   1380

ttaacgcagt accccagata caagaaatac cagcttgcat gtaccaagaa tgtctataat   1440

gcatcatcac acagtacctc aggttttgca agcacattcc gggaagataa ctctagcaac   1500

agcctcaagc cggggcttgc cagggggcag attaaaagtg agccgcccag tgaagagaat   1560

gaggaagaga gcatcacgct ctgcctgtct ggagatgagc ctgacgccaa ggacagagcg   1620

ggggatgtcg agatggaccg gaaacagccc agccctgccc ctacccccac ggccccagct   1680

ggggccgcct gcctggagag atccaggagc gtggcctcgc cctcctgctt aaggtctctg   1740

ttcagcataa cgaaaagtgt ggagctgtct ggcctgccca gtacatctca gcagcacttt   1800

gccaggagtc cagcctgccc ttttgacaag gggatcactc agggtgacct taaaactgac   1860

tacacccctt tcacagggaa ttatggacag ccccacgtgg gccagaagga ggtgtccaac   1920

ttcaccatgg ggtcgcccct cagggggcct gggttggagg ctctctgtaa acaggaggga   1980

gagctggacc ggaggagcgt gatcttctcc tccagcgctt gtgaccaagt gagcacctcg   2040

gtgcattctt attctggggt gagcagtttg gacaaagacc tctctgagcc ggtgccaaag   2100

ggtctgtggg tgggagccgg ccagtccctc cccagctcgc aggcctactc ccacggtggg   2160

ctgatggccg accacttgcc aggaaggatg cggcccaaca ccagctgccc ggtgccaatc   2220

aaagtctgcc ctcgctcacc ccccttggag accaggacca ggacttccag ctcctgctct   2280

tcctattcct acgcggagga cgggagcggg ggctcaccct gcagcctccc tctctgtgag   2340

ttctcctcct cgccctgttc ccagggagcc agattccttg ccacagaaca tcaggaacca   2400

ggcctgatgg gagatggaat gtacaaccaa gtgcggcccc aaattaaatg tgagcagtct   2460

tatggaacca actccagtga cgaatccgga tcgttctcgg aagcagacag tgagtcgtgt   2520

cctgtgcagg acaggggcca ggaggtaaaa cttccttttc ctgtagatca aatcacagat   2580

cttccaagga acgatttcca gatgatgatt aaaatgcaca agctaacctc agaacagtta   2640

gagtttattc atgatgtccg acggcgcagc aagaaccgca tcgcggccca gcgctgccgc   2700

aaaaggaaac tggactgtat tcagaattta gaatgtgaaa tccgcaaatt ggtgtgtgag   2760

aaagagaaac tgttgtcaga gaggaatcaa ctgaaagcat gcatggggga actgttggac   2820

aacttctcct gcctttccca ggaagtttgc cgagacatcc agagccccga gcagatccag   2880

gccctgcatc ggtattgccc tgtcctcaga cccatggact tgcccacggc ctccagtatt   2940

aaccctgcgc ccttgggtgc tgagcagaac attgcggcct cccaatgcgc agtgggggaa   3000

aacgtgccct gctgcttgga gccaggcgcg gctccccccg gacccccctg ggcacccagc   3060

aacacctccg agaattgtac ctctgggagg agactagaag gcactgaccc gggaaccttc   3120

tcagagagag gacctcctct tgaacccagg agccaaacag tgaccgtgga cttctgccag   3180

gaaatgactg ataagtgtac aactgacgaa cagcccagga aagattatac ctagtgactc   3240

ggctctgcct cccagtccgc acacctctcc catccaggcg ttcttcagtc agcctgtggc   3300

actgttcatc tgctgtcccg aagaaaccga gaacacattt ggtgcacact acagcggtct   3360

tagcagcaat actgttccga agtatcctct cctcttctcg agcaggagtg atagttacct   3420

tcacaatggt gctacccctt gcccaggcaa ggaaagacag cagtgatgac actgtctgtc   3480

tgtggctcaa tttcagtctt cacagggata gactacaaca cctctaggcc ccaaccacgg   3540

attttttttc tcagtggccc atgtcacaaa ccctatctca ggaatttctt ctgaatgttc   3600

aatttttttc attgaagaca gcttctatac acatcaaagt tttatagcta gactgtacat   3660

attatatata atatatatat aaaaaatata tatatatata tatatccata tgcaaaagtc   3720

ctgcatgcct caactttctc atcctaaaac tggaaactta tttctcattt agaaacaggt   3780

tccaacattc ctcttctttt gtctctgatg ctagaactag tttggtaact gttaacgtgg   3840

tcatttttct tgcttcacag ttcaattttc aattcgtact tatttatgga caaaattcag   3900

tgttggaagc tttttcccaa ggttttattt cagatttctt tttcgtttgg tttggttttg   3960

gcacctccaa gtggtgtcat ttgagcattg taggtttgtt ttttgtttgt ttggggggtt   4020

ttgtttgttt ttgtttttgt ttttgttttc cttgcagata ctgtacagta atggtcaact   4080

ttgccacttg cactgagttt tgggtcaaac ctattttctt aaatgaagtt gtaacttcgg   4140

tataactcaa gtatactgta tattctttgc ttttagttaa aaaagtaaaa cattttagct   4200

aattaaaaag cactcaggtg ataattatgt aggaaaaaca atcttgccaa ataatgaatt   4260

catcctagga tgtgtagaca ataatctgct tgaatatttt tatatttcac ctcctcccca   4320

cctttcccta agcaaagttt aaacgcagat agagagttca gagttgatgc tggatgttca   4380

gattcctaag tggggagaga gtttggacat ctcactcaaa agtacatcag aaaaacagga   4440

atccgtgatt ttataccaga actcagcagg cattggctcc tagaaatcaa gttagaaagt   4500

tttcacccag ggagtaagtc ccattcattt caacacgtcc tgaggcctcg gcttgctctt   4560

ggaagtggtg tgcagtagga cctgctcccc tgaaggacgg ggccaaccag ccactggctt   4620

tcctgcccag gcttggcctc ccaggacatc tggcctgagg ggatttgaat cacagccccg   4680

aaggtcctgc cttcacccca ttgggagaga gcagggcatc ctggcatctg cgatccatcc   4740

ctgacacagg ctgacacatt ctttctcctt tccttctcca aaggcttgga gttttcttct   4800

gaggtttttc tgccagtgtc ttgtctgaag gcagacttca ttctgaggct ttggacaagc   4860

tattcaccgg gaaccctccc tgtccccttc ccgaatcaca cacataccct accctcacct   4920

gatgataatt ttctcttctt gctgcaaaac tggttggctt gcaacccaga gagagcagct   4980

tcccttggct ctgggggccg tgttggcccc agccacgttt acaggaaggt gtgccccaga   5040

ggaggaggaa tcagctccct cgctccagtg gccttgggtc cgggtctcac tgagcagccc   5100

gagggccact ccagcccggc tggggaagag agtcctgaac ggtttgatgt ggggatgggg   5160

tggtgggcag tggggaatag atggttgact ttgtttcttt atttgtgcca ttgtttggac   5220

aatattaaag ctgcatgtaa aaggggaaat tagtatatga tgtaggctaa aagtgaaatc   5280

atagtaacat atgttttagt attattaact tttttctgta caaatattag cactaaatgt   5340

ttaaatatgt atgaatgcca gaaatttgtc agttcatgca gtaggataaa aaaaaaaaaa   5400

aaaaaaaaag ggcttttctt tttaaacagt tccactttta aaacctgcct ctgggttttt   5460

gttttttctt gtttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt   5520

gtctgaaaca gatcttgata aagctctgtg ttggagctgc tggtttttgt tatggttgtt   5580

ggaatttctt ggcctactag gacagttctg tgcttcacca tgaggtttgc ctttgtggaa   5640

aactcgtggg tgacagtgag aatataaact caatgtgaat cacgtgatac ttcggcaggc   5700

gtgtgttaca gtggagtcag ctgacagtat tttgcttttt aactctattg ttgcctttcc   5760

aagtgacctc tcctcttctt ttaaaaaaag aacactttct gctcatatca taaccaggtc   5820

caacccagct tcttggcatg aggtttaccc tggtaacaac tcatgtgcaa ctggtagtct   5880

tgaccacatt ccatccattt cctcaggttt ctgtggttca gtagcccaga cctgtttggc   5940

agccatttct agcaggggcg gggcctcttt atttctctcc accctaactc agacctcacc   6000

ttcctcccac ccacccctgc cttgcttttc ttcctcttcc cccaacctaa cttctgccat   6060

gggaactggt taaaaacact gctctaaaaa ccatcttcca atttcataga gatttctcac   6120

aagttatttc attcataatc caccatgaac agtgactagc ttcgtgcagt tgttcatgtg   6180

atgtgtgtgt gtcttttcct attcagaact atgtgcttgt caaaattatt tctgggttga   6240

ttcaaaggga ggacttgctg gggaccagaa tccaaacggc ctcaagtgga attttaaaac   6300

ctagcctgtc tcttttccct gggatccctc tgtcaacccc acgcctttta ggaaaaagaa   6360

aagtgagtga acagcaagga agagtgtttg cacagtacag taacatttgg ttgttcttaa   6420

ggctcttttc ttacaaaaat aagagaccct ccaaccacgg gctgtttagg aggatgcctg   6480

cttgggtctc caaatggctg gggtaggaat ggttgttggg gcagagccag tggaggtgag   6540

tgaccctgag actaatgaac atcccaccta aatccagtcc tccccttgga tctgcctttg   6600

tcctgcttgt gtatccaggc aacctctttt caagttggtc aggctttgga caggtgagtg   6660

atttgctgta tgtgtttgtt tctctgcgtt acctgggggt gccttgatta aaatcgaact   6720

ttattacata ctgattctgg aacaaaacag ttagaaaaac tttaaacttt aaaaaaaaaa   6780

aaaccgacaa agttacgagg ccatcctgct atttatcttc tgagttccca gcaatgactc   6840

aggcatcaga gatgatgctg cagtggaaaa cctgactctg tgtgtctgca actgaatgtt   6900

gtgcgagtaa tttattaact gtctttctaa aggtttgctg cttttaagat gcactataat   6960

tcgggatgta atccttacat tgcttttcca aggaagggaa caaaagtcta gtgattagta   7020

tgccaactgc cactactcct tcaaaaggag ccaggaccag cgacaagact catgagagga   7080

ctggctaaag tgaagtgtgc acagtgtgaa gtttaatgct gttgtcaaga ggcctaaacc   7140

cacattttct cttttaatat tttatgattg ccatcaaaga agaagaaaaa gaaggaacag   7200

acaaaggttt gaaaatgata agcctgttaa gacaccaaaa actcctgtcc cgtgaagctg   7260

cttgacatcc tgtggagtag cataatcctc tcaaaatgag gaagagctgc ctgcaaagct   7320

ttctcaagtc cctatttggc tacctacttc tctacattat gccccattta aactaggagc   7380

tgtcttagaa atgacttcaa actgcttcac tattgcttac agtttaggag gagtctcaga   7440

tccagaagga gcaagaatca agtttggtcc tcaaatgact gtaaatagac taaagaacaa   7500

ggtgtttttt gtttttgttt ttgttttcta agaataaagc tgttcgttgt atcatgagtt   7560

agtgtttctt ccccaaactg aagactgtgt tggaagtgca atttctggtg agtcagtcca   7620

caatacaatg ccctgtgtgg agttggtatt catacaggaa atctgtgtgc acgaggcatt   7680

gtgtgttgaa agtgtatgtt tatagtactg cctgagccat ctcatgaccc cagcgtccaa   7740

aaccgatgct gtagaacaga acatatctgt cacaaatagg tgtgtgcaaa tagcatttgt   7800

acatagaaaa gtctcattgt ggcagattga gcataaatta ttcaactgac ggtgcaaaaa   7860

cattacttgc aaagaaaagt ttatagtatt ttcctacact ccaccctggg agatgatatt   7920

tctatcaaat gaatatcagt gcattttaaa tgtaatatga aaacgatgct gccattttgt   7980

gaagaatacc cacttggttg cagaggccaa ctttcatagc tttgatttaa tgttgtgaca   8040

cggtgtatgc attttgctgt caagcaatgg ataaacagct ctgactttca ttctcattcc   8100

agtttattga cctcagataa aacactggcc cttcttagaa gcagaagtgt gcaccaagac   8160

cattcatttc aggtagactc acattcagtg cc                                 8192


<210>  432
<211>  841
<212>  PRT
<213>  Homosapiens

<400>  432

Met Ser Val Asp Glu Lys Pro Asp Ser Pro Met Tyr Val Tyr Glu Ser 
1               5                   10                  15      


Thr Val His Cys Thr Asn Ile Leu Leu Gly Leu Asn Asp Gln Arg Lys 
            20                  25                  30          


Lys Asp Ile Leu Cys Asp Val Thr Leu Ile Val Glu Arg Lys Glu Phe 
        35                  40                  45              


Arg Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu Tyr Phe Trp Gln 
    50                  55                  60                  


Ala Leu Val Gly Gln Thr Lys Asn Asp Leu Val Val Ser Leu Pro Glu 
65                  70                  75                  80  


Glu Val Thr Ala Arg Gly Phe Gly Pro Leu Leu Gln Phe Ala Tyr Thr 
                85                  90                  95      


Ala Lys Leu Leu Leu Ser Arg Glu Asn Ile Arg Glu Val Ile Arg Cys 
            100                 105                 110         


Ala Glu Phe Leu Arg Met His Asn Leu Glu Asp Ser Cys Phe Ser Phe 
        115                 120                 125             


Leu Gln Thr Gln Leu Leu Asn Ser Glu Asp Gly Leu Phe Val Cys Arg 
    130                 135                 140                 


Lys Asp Ala Ala Cys Gln Arg Pro His Glu Asp Cys Glu Asn Ser Ala 
145                 150                 155                 160 


Gly Glu Glu Glu Asp Glu Glu Glu Glu Thr Met Asp Ser Glu Thr Ala 
                165                 170                 175     


Lys Met Ala Cys Pro Arg Asp Gln Met Leu Pro Glu Pro Ile Ser Phe 
            180                 185                 190         


Glu Ala Ala Ala Ile Pro Val Ala Glu Lys Glu Glu Ala Leu Leu Pro 
        195                 200                 205             


Glu Pro Asp Val Pro Thr Asp Thr Lys Glu Ser Ser Glu Lys Asp Ala 
    210                 215                 220                 


Leu Thr Gln Tyr Pro Arg Tyr Lys Lys Tyr Gln Leu Ala Cys Thr Lys 
225                 230                 235                 240 


Asn Val Tyr Asn Ala Ser Ser His Ser Thr Ser Gly Phe Ala Ser Thr 
                245                 250                 255     


Phe Arg Glu Asp Asn Ser Ser Asn Ser Leu Lys Pro Gly Leu Ala Arg 
            260                 265                 270         


Gly Gln Ile Lys Ser Glu Pro Pro Ser Glu Glu Asn Glu Glu Glu Ser 
        275                 280                 285             


Ile Thr Leu Cys Leu Ser Gly Asp Glu Pro Asp Ala Lys Asp Arg Ala 
    290                 295                 300                 


Gly Asp Val Glu Met Asp Arg Lys Gln Pro Ser Pro Ala Pro Thr Pro 
305                 310                 315                 320 


Thr Ala Pro Ala Gly Ala Ala Cys Leu Glu Arg Ser Arg Ser Val Ala 
                325                 330                 335     


Ser Pro Ser Cys Leu Arg Ser Leu Phe Ser Ile Thr Lys Ser Val Glu 
            340                 345                 350         


Leu Ser Gly Leu Pro Ser Thr Ser Gln Gln His Phe Ala Arg Ser Pro 
        355                 360                 365             


Ala Cys Pro Phe Asp Lys Gly Ile Thr Gln Gly Asp Leu Lys Thr Asp 
    370                 375                 380                 


Tyr Thr Pro Phe Thr Gly Asn Tyr Gly Gln Pro His Val Gly Gln Lys 
385                 390                 395                 400 


Glu Val Ser Asn Phe Thr Met Gly Ser Pro Leu Arg Gly Pro Gly Leu 
                405                 410                 415     


Glu Ala Leu Cys Lys Gln Glu Gly Glu Leu Asp Arg Arg Ser Val Ile 
            420                 425                 430         


Phe Ser Ser Ser Ala Cys Asp Gln Val Ser Thr Ser Val His Ser Tyr 
        435                 440                 445             


Ser Gly Val Ser Ser Leu Asp Lys Asp Leu Ser Glu Pro Val Pro Lys 
    450                 455                 460                 


Gly Leu Trp Val Gly Ala Gly Gln Ser Leu Pro Ser Ser Gln Ala Tyr 
465                 470                 475                 480 


Ser His Gly Gly Leu Met Ala Asp His Leu Pro Gly Arg Met Arg Pro 
                485                 490                 495     


Asn Thr Ser Cys Pro Val Pro Ile Lys Val Cys Pro Arg Ser Pro Pro 
            500                 505                 510         


Leu Glu Thr Arg Thr Arg Thr Ser Ser Ser Cys Ser Ser Tyr Ser Tyr 
        515                 520                 525             


Ala Glu Asp Gly Ser Gly Gly Ser Pro Cys Ser Leu Pro Leu Cys Glu 
    530                 535                 540                 


Phe Ser Ser Ser Pro Cys Ser Gln Gly Ala Arg Phe Leu Ala Thr Glu 
545                 550                 555                 560 


His Gln Glu Pro Gly Leu Met Gly Asp Gly Met Tyr Asn Gln Val Arg 
                565                 570                 575     


Pro Gln Ile Lys Cys Glu Gln Ser Tyr Gly Thr Asn Ser Ser Asp Glu 
            580                 585                 590         


Ser Gly Ser Phe Ser Glu Ala Asp Ser Glu Ser Cys Pro Val Gln Asp 
        595                 600                 605             


Arg Gly Gln Glu Val Lys Leu Pro Phe Pro Val Asp Gln Ile Thr Asp 
    610                 615                 620                 


Leu Pro Arg Asn Asp Phe Gln Met Met Ile Lys Met His Lys Leu Thr 
625                 630                 635                 640 


Ser Glu Gln Leu Glu Phe Ile His Asp Val Arg Arg Arg Ser Lys Asn 
                645                 650                 655     


Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys Leu Asp Cys Ile Gln 
            660                 665                 670         


Asn Leu Glu Cys Glu Ile Arg Lys Leu Val Cys Glu Lys Glu Lys Leu 
        675                 680                 685             


Leu Ser Glu Arg Asn Gln Leu Lys Ala Cys Met Gly Glu Leu Leu Asp 
    690                 695                 700                 


Asn Phe Ser Cys Leu Ser Gln Glu Val Cys Arg Asp Ile Gln Ser Pro 
705                 710                 715                 720 


Glu Gln Ile Gln Ala Leu His Arg Tyr Cys Pro Val Leu Arg Pro Met 
                725                 730                 735     


Asp Leu Pro Thr Ala Ser Ser Ile Asn Pro Ala Pro Leu Gly Ala Glu 
            740                 745                 750         


Gln Asn Ile Ala Ala Ser Gln Cys Ala Val Gly Glu Asn Val Pro Cys 
        755                 760                 765             


Cys Leu Glu Pro Gly Ala Ala Pro Pro Gly Pro Pro Trp Ala Pro Ser 
    770                 775                 780                 


Asn Thr Ser Glu Asn Cys Thr Ser Gly Arg Arg Leu Glu Gly Thr Asp 
785                 790                 795                 800 


Pro Gly Thr Phe Ser Glu Arg Gly Pro Pro Leu Glu Pro Arg Ser Gln 
                805                 810                 815     


Thr Val Thr Val Asp Phe Cys Gln Glu Met Thr Asp Lys Cys Thr Thr 
            820                 825                 830         


Asp Glu Gln Pro Arg Lys Asp Tyr Thr 
        835                 840     


<210>  433
<211>  2515
<212>  DNA
<213>  Homosapiens

<400>  433
aatcacacaa gaccttaaaa gctgagaact tcctcctgct ggggacagga cagatgaggc     60

agaaggggag gttagggagg tttgaagagt gagaagaact tctgcagtgg ctgacttgga    120

agatgaagga ggttatgaac cagggaatgg gggcagcctc tagaggctga gaacctgctg    180

acacctaccc acaaccgcta aggaaatgaa gactttaatt ccacaactgc atgcaactaa    240

actcagccaa caacctgaat aagtcggaaa aaggcttctc cagagcctcc agataagagg    300

ccaggctggc gacaccttga ttttgacctt gtgagaccta gagcagagaa actagccaag    360

atcactcaga cttctgatct acagaactgt gagaccgtaa atttatgttg tattaagcca    420

ctaattgcgt gggaatttgt tacaggagca atagaaaatg aatacacctt ctgatgtagt    480

ttaatcagtt gacattagac tcctcccgtt tgtaatatgg agatttattt acaatggcga    540

gagctgctat ggggccatcc ataataacac agaagtcttg gccgacaaac accagaagga    600

gctgtctgga aggtttgaat aaataaacct gggtgggaag tatacagtta ttgtgcatca    660

ccaatgaatg aatcaggttg agttccatcc tcttcaccta aaacttcctt aagtgagtga    720

caagcgtagt ataaatcaga aaaccgagcc atcaagaagc ttgccttgac caacgactca    780

aatcacatca agcagaacca gaagagaact ttacacctgt atcttcagcc ccacagtaaa    840

acccaatgac acgatgaatg ccatttaatc tgtgtgattt caccatgaaa tctaaaccat    900

catttgaaag gctgctgaat gtggtaccag tgacacactt tgtgcctaac tctcttaact    960

ttttgctcat ttgattgcca tacaactcta gaaatctgat tttaaaacaa ttaccttagg   1020

ttccagggaa taattacttt aatgatcttt taaatatttt ccccctaaga gttgaccttg   1080

ctgtaaattc tttattgcct atttatatgg tgatagggga ttaggcaggc actgttcttg   1140

agtctttact gagctaaagg aaagtggcca atagatggcc taaaagaatc atggggaaat   1200

gtttaagggg gaattgaaaa ttcagtattt tcacaagcta caaaaacatc caaagtcaat   1260

gataaaaaca gatgtattat ggcaaattag cagtagaggg aaacagaaaa tgtcgttttc   1320

tgaatgagga cttagagtgg gaagctgtcc tttaactatt atatatattt taaaataatt   1380

ttattgatat acgaaaacta atttagaaac cacattaata aattaataaa attattaaaa   1440

tgatggtact ccatgaattt ttaacaagaa tattccctat gttacactta caagaaatct   1500

tttttgataa cgtaaagtca taatttgcaa aatatttggc actcttgttt gctttctgct   1560

tcactatctt tgagtctgtg acaggtagct gatggtaaac ctcataggat ttggagttat   1620

atttgaagac actatccaag atatttattt gaacttacac aaaaaggcta ttttcaccct   1680

taatattaaa aagctgagat gcatcccagg aggcaaatat cactcatgta cctggaagct   1740

tttactaaat gggtgacacc aagatgtgct acactgaacc caacttctgc atgtttaaga   1800

caagaatgtg catctttatt tttcctgaat atttctattg tctaaatacc ttaacgcaag   1860

gtcaaaaatt tacatcaggt atctgaatgt gtagcatata caactgagtg ttgaaagaag   1920

acaaaatcgt tttcatcacg aagaatatgt gctcagtaag aatcagaatg ttcaattgtg   1980

tgaaggtggg agatgggaag attggtatta tggcctggat ccagaaatca gtcttccact   2040

ataggaaatg ggaatttaaa gatgatcaga agacagttgg gagcagagtg agaataagaa   2100

ccctcaactg ctgtctcacc tttcagatca cgaagaagtt ttttacaatg agcagaacac   2160

tcaacctgaa agcagaatgg attgagtcac tgcagcgtgg cagtggaatg gtgtttgatg   2220

ttggcaaagg aaacatgtac ttctagactg gacagttttc ccttagttta cagtttccaa   2280

atagagacat cactttgaaa taacatggag aacatacatg gatgtactga acgaagaata   2340

aagtctgtgt tgcagtcctg tctccattga cttttacaaa tatggctttg gatgaatcac   2400

ctaagtttta tttttgagaa tttacgctta ccatgtataa aatgatattg ctaatatgtt   2460

tgctgcctac cccattgggt tttgtgagga ataaatgata atgctaagaa aaagg        2515


<210>  434
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  434

Met Phe Asn Cys Val Lys Val Gly Asp Gly Lys Ile Gly Ile Met Ala 
1               5                   10                  15      


Trp Ile Gln Lys Ser Val Phe His Tyr Arg Lys Trp Glu Phe Lys Asp 
            20                  25                  30          


Asp Gln Lys Thr Val Gly Ser Arg Val Arg Ile Arg Thr Leu Asn Cys 
        35                  40                  45              


Cys Leu Thr Phe Gln Ile Thr Lys Lys Phe Phe Thr Met Ser Arg Thr 
    50                  55                  60                  


Leu Asn Leu Lys Ala Glu Trp Ile Glu Ser Leu Gln Arg Gly Ser Gly 
65                  70                  75                  80  


Met Val Phe Asp Val Gly Lys Gly Asn Met Tyr Phe 
                85                  90          


<210>  435
<211>  4196
<212>  DNA
<213>  Homosapiens

<400>  435
cggccctccc atgtgcagcc cggccagccg ggctctcctc ctcgcggcgg atgggtgacc     60

ttttcctggc acgggcaggc tgtgggaggc agcggagcag gcgatgaaga agaagcagca    120

gcatcccggc ggcggcgcgg atccctggcc ccatggggcc cctatggggg gcgcccctcc    180

gggcctgggc agctggaagc gtcgggtgcc cctgctgcct ttcctgcgct tctccctccg    240

ggactacggc ttctgcatgg ccaccctgct ggtcttctgc ctgggctccc tcctctatca    300

gctcagcggg ggaccccctc gcttcctgct cgacctgcgg cagtacttgg gaaattccac    360

ttacttggat gaccatggac cacctcctag taaggtacta cctttcccaa gccaggtggt    420

gtacaacagg gtaggcaagt gtgggagccg tactgtggtc ttgcttctga gaatcttgtc    480

ggagaagcac ggatttaatt tggtcacatc agacattcac aacaaaacca ggcttactaa    540

aaatgaacaa atggaactga ttaaaaatat aagtactgcc gaacaaccct atttattcac    600

tcgacatgtt catttcctca acttctcaag gtttggagga gaccagcctg tctacatcaa    660

catcattaga gaccccgtca accggttctt atccaactat tttttccgtc gctttggaga    720

ctggagaggg gaacaaaatc acatgatccg cacccccagc atgaggcagg aggagcgcta    780

cctggatatc aatgagtgta ttcttgaaaa ctatcccgag tgctccaacc ccaggttatt    840

ttacatcatt ccgtactttt gtggacagca tcccagatgc agggagcctg gtgaatgggc    900

ccttgagaga gcaaagctga acgtgaatga aaacttcctg ctcgtgggga ttcttgaaga    960

gttggaagat gtgctgctgt tactggaaag atttttacct cattacttca agggcgtgct   1020

cagtatctac aaagacccag agcacaggaa gcttggaaac atgactgtga cggtgaagaa   1080

gactgtcccc tctcctgagg ctgtgcagat cctctaccag cggatgagat acgagtacga   1140

gttttaccac tacgtcaaag agcagttcca cctgctgaag cgcaagtttg gacttaagtc   1200

tcacgtcagc aagccccccc tgaggccaca cttctttatc ccaactccac tggaaaccga   1260

ggagccaatc gacgatgaag aacaggatga tgaaaagtgg ctggaagata tttataagag   1320

gtgatgtgac tgtgttgcct ctatggcttt atctcccttt tccagaaagt tctttgtttg   1380

gggaagtaaa atccttaagg gactaaatta atgcttgggt gcattaaaaa gaacaaaaca   1440

ttcccacatg ttggggtcat tgggagatgc ccggttttgc gggttttatt tgtttaattt   1500

tattctgtgt tttctcttgg ctctttgggt ctttcccggg tacactagat ggctccatcc   1560

caaggcatct tgtcataaaa cagctttccc ccaccccata tcatgggaaa agggggagaa   1620

atatagcccc tagcctaata acttatcatt tgtaaaatga cttataaaaa tattacctca   1680

atggtaggag acatccagac ttgtatattt cagtggaaat acaaaaccac ttcagagacc   1740

agggtatctc ctctggaagg atctaagaga aggtaagaca gattaggaca tcgaaaagga   1800

ggatggagcc aggtgccatg gcttgagcct ataatccgag gctgaggtgg gaggatcact   1860

tgagcccagg agtttgaggt tgcagtgagc tgtgatcaca ccactgcact ccagcctggg   1920

tgacagagtg agactctgtc tcaattaatt tttttttttt aaaggaggag gatctccatg   1980

ggtaagtggt ttctacccgc atgggtagag ttctgcctct ggtccttctc agggggcact   2040

ttcaccaaga gcagtgtaat tatctctgaa agagcaagtc agcttgtgcc gcatccccaa   2100

ccaatccaca gcctggagta cctttcaagg tcaaagtgca tggccagctc cattgagaca   2160

ttccatttca aagcaccgtg ctgacagata tcaaagtact ctagcaggga aaataatttg   2220

tttgctgtgt aaggaagaat gtagacaaga cagataaatc tgaaggtcat gtggcatcag   2280

ggaaagggca tggctgtgtc ttttgcaccc aatatgaaac atcttctccc aacactgctt   2340

taatggaagt tctaggaacc aatttagctc aggcatttga ctcctacagc agaagttctg   2400

agcctgacca cagatggtgt gtaatctatc aaacacaccc ctggccaagt tgggtcctat   2460

aggacctggt actatgtact attgtaactt ctagttccct aagaggtacc tgttttcagt   2520

aaaaaggggt cctgagttct gtgcaggtgg aagagctacc cgagaactac ctgagttctg   2580

tgcaggtaga gtcccatttc ttatgggacc tgtgtgctcc tgagaactct tacttgagac   2640

atcaaaaaga agcagcaaga gcttctggga cagagactgc ttggccagct ttgtaagtaa   2700

gtggctgcct ccaatgtgat gtgagtacat gttgggcagt ctcactgtcc taaggtatgt   2760

cttctttcca cctcccactg cccctcccct gccacctatc aatgatgcct tggttcagtc   2820

attagaaatc tgttgctttg agttctgaaa tattttcacc ttaaaaaaaa tgctgaaaat   2880

acacattctc ctgggaagac gataaacagc tagctaagaa gccgaggttc agtggtggca   2940

gcaggaagga cactgccaca aattttgtct atttcatatt tgtcccctag agccagccct   3000

agcaaatgtg tgagttggga gtagttaata gtaaataaga ctctgacttt acacaagcta   3060

cacattttat acttttcata aaccacaaag tctctctaga attttttctg ccttcactaa   3120

aattggactg tagccaagat ataaagcaag tcatttggaa cctgccgagt gagcactgaa   3180

gctactttat catgagatgt gtgttaagaa ggctgcagcc cacaggagtc cagggaaggc   3240

ggggaccaca gaggcacaga gtccagcact tggccgctca tgggccttct ttctgcctca   3300

gaggacgggg gcagagaagt gatgaaggga aatgttctta gaggaggaaa tatcctttgt   3360

cctgttcaga gagaccaggg ccctaccatt aggcatactt tcagaagcaa cctggagaac   3420

agctatcaat catattcaaa accagtacaa gaactgctgc ctggtaccct gtgagtcatt   3480

tctatgaaat tccatataaa gaatgatgat aagtttacac actgtgcaat ctcacaatct   3540

gaaaataaag ttgagttggc tgtgttttct ctgctcttgt cagaacattg ggacaattgg   3600

tcgttcaaaa acattcatcc tcttactgca agtttatctg ggtactttta cctgtgtgtt   3660

caaaggcatt tcttttcagc agtgatcatt ataacttcac aaaaaaagat gctgacggat   3720

ttacttacag ggccttaatg ttattttgtc ccagccaaca ccctctaggt cctaaaagtc   3780

aaggtacttc agtttatttg gcaaacatga caacattttt ttggccctgg gcccaacagt   3840

ttgtacttca tgaaacatat tgtacatttt acatagttta atttaaaaaa taccttttaa   3900

gctagttgat ctttgactgt cttatttatt ataacctttc agcacattcc aaggttttag   3960

ttactcagga aggagttaat taaaatgatt ttattttggt ctgatggatg ttttttaaaa   4020

ggaaaattat tattatgaac cttcagccta ctttcttgag tgccgtaaaa gtgcttgtaa   4080

atcttttttt ttttttaaga agaaagaaaa aaatggtgtt tgacgttgat ggaaattcaa   4140

aaatatatat ggaactgaaa cattaactta gctaaaataa aagcaatctg tgtttg       4196


<210>  436
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  436

Met Lys Lys Lys Gln Gln His Pro Gly Gly Gly Ala Asp Pro Trp Pro 
1               5                   10                  15      


His Gly Ala Pro Met Gly Gly Ala Pro Pro Gly Leu Gly Ser Trp Lys 
            20                  25                  30          


Arg Arg Val Pro Leu Leu Pro Phe Leu Arg Phe Ser Leu Arg Asp Tyr 
        35                  40                  45              


Gly Phe Cys Met Ala Thr Leu Leu Val Phe Cys Leu Gly Ser Leu Leu 
    50                  55                  60                  


Tyr Gln Leu Ser Gly Gly Pro Pro Arg Phe Leu Leu Asp Leu Arg Gln 
65                  70                  75                  80  


Tyr Leu Gly Asn Ser Thr Tyr Leu Asp Asp His Gly Pro Pro Pro Ser 
                85                  90                  95      


Lys Val Leu Pro Phe Pro Ser Gln Val Val Tyr Asn Arg Val Gly Lys 
            100                 105                 110         


Cys Gly Ser Arg Thr Val Val Leu Leu Leu Arg Ile Leu Ser Glu Lys 
        115                 120                 125             


His Gly Phe Asn Leu Val Thr Ser Asp Ile His Asn Lys Thr Arg Leu 
    130                 135                 140                 


Thr Lys Asn Glu Gln Met Glu Leu Ile Lys Asn Ile Ser Thr Ala Glu 
145                 150                 155                 160 


Gln Pro Tyr Leu Phe Thr Arg His Val His Phe Leu Asn Phe Ser Arg 
                165                 170                 175     


Phe Gly Gly Asp Gln Pro Val Tyr Ile Asn Ile Ile Arg Asp Pro Val 
            180                 185                 190         


Asn Arg Phe Leu Ser Asn Tyr Phe Phe Arg Arg Phe Gly Asp Trp Arg 
        195                 200                 205             


Gly Glu Gln Asn His Met Ile Arg Thr Pro Ser Met Arg Gln Glu Glu 
    210                 215                 220                 


Arg Tyr Leu Asp Ile Asn Glu Cys Ile Leu Glu Asn Tyr Pro Glu Cys 
225                 230                 235                 240 


Ser Asn Pro Arg Leu Phe Tyr Ile Ile Pro Tyr Phe Cys Gly Gln His 
                245                 250                 255     


Pro Arg Cys Arg Glu Pro Gly Glu Trp Ala Leu Glu Arg Ala Lys Leu 
            260                 265                 270         


Asn Val Asn Glu Asn Phe Leu Leu Val Gly Ile Leu Glu Glu Leu Glu 
        275                 280                 285             


Asp Val Leu Leu Leu Leu Glu Arg Phe Leu Pro His Tyr Phe Lys Gly 
    290                 295                 300                 


Val Leu Ser Ile Tyr Lys Asp Pro Glu His Arg Lys Leu Gly Asn Met 
305                 310                 315                 320 


Thr Val Thr Val Lys Lys Thr Val Pro Ser Pro Glu Ala Val Gln Ile 
                325                 330                 335     


Leu Tyr Gln Arg Met Arg Tyr Glu Tyr Glu Phe Tyr His Tyr Val Lys 
            340                 345                 350         


Glu Gln Phe His Leu Leu Lys Arg Lys Phe Gly Leu Lys Ser His Val 
        355                 360                 365             


Ser Lys Pro Pro Leu Arg Pro His Phe Phe Ile Pro Thr Pro Leu Glu 
    370                 375                 380                 


Thr Glu Glu Pro Ile Asp Asp Glu Glu Gln Asp Asp Glu Lys Trp Leu 
385                 390                 395                 400 


Glu Asp Ile Tyr Lys Arg 
                405     


<210>  437
<211>  6158
<212>  DNA
<213>  Homosapiens

<400>  437
gttgatagaa gtccagatcc tgaggaaatc tccagctaaa tgctcaaaat ataaaatact     60

gagctgagat ttgcgaagag cagcagcatg gatggatttt atgaccagca agtgccttac    120

atggtcacca atagtcagcg tgggagaaat tgtaacgaga aaccaacaaa tgtcaggaaa    180

agaaaattca ttaacagaga tctggctcat gattcagaag aactctttca agatctaagt    240

caattacagg aaacatggct tgcagaagct caggtacctg acaatgatga gcagtttgta    300

ccagactatc aggctgaaag tttggctttt catggcctgc cactgaaaat caagaaagaa    360

ccccacagtc catgttcaga aatcagctct gcctgcagtc aagaacagcc ctttaaattc    420

agctatggag aaaagtgcct gtacaatgtc agtgcctatg atcagaagcc acaagtggga    480

atgaggccct ccaacccccc cacaccatcc agcacgccag tgtccccact gcatcatgca    540

tctccaaact caactcatac accgaaacct gaccgggcct tcccagctca cctccctcca    600

tcgcagtcca taccagatag cagctacccc atggaccaca gatttcgccg ccagctttct    660

gaaccctgta actcctttcc tcctttgccg acgatgccaa gggaaggacg tcctatgtac    720

caacgccaga tgtctgagcc aaacatcccc ttcccaccac aaggctttaa gcaggagtac    780

cacgacccag tgtatgaaca caacaccatg gttggcagtg cggccagcca aagctttccc    840

cctcctctga tgattaaaca ggaacccaga gattttgcat atgactcaga agtgcctagc    900

tgccactcca tttatatgag gcaagaaggc ttcctggctc atcccagcag aacagaaggc    960

tgtatgtttg aaaagggccc caggcagttt tatgatgaca cctgtgttgt cccagaaaaa   1020

ttcgatggag acatcaaaca agagccagga atgtatcggg aaggacccac ataccaacgg   1080

cgaggatcac ttcagctctg gcagtttttg gtagctcttc tggatgaccc ttcaaattct   1140

cattttattg cctggactgg tcgaggcatg gaatttaaac tgattgagcc tgaagaggtg   1200

gcccgacgtt ggggcattca gaaaaacagg ccagctatga actatgataa acttagccgt   1260

tcactccgct attactatga gaaaggaatt atgcaaaagg tggctggaga gagatatgtc   1320

tacaagtttg tgtgtgatcc agaagccctt ttctccatgg cctttccaga taatcagcgt   1380

ccactgctga agacagacat ggaacgtcac atcaacgagg aggacacagt gcctctttct   1440

cactttgatg agagcatggc ctacatgccg gaagggggct gctgcaaccc ccacccctac   1500

aacgaaggct acgtgtatta acacaagtga cagtcaagca gggcgttttt gcgcttttcc   1560

ttttttctgc aagatacaga gaattgctga atctttgttt tatttctgtt gtttgtattt   1620

tatttttaaa taataataca caaaaagggg cttttcctgt tgcattattc tatggtctgc   1680

catggactgt gcactttatt tgagggtggg tgggagtaat ctaaacattt attctgtgta   1740

acaggaagct aatgggtgaa tgggcagagg gatttgggga ttacttttta cttaggcttg   1800

ggatggggtc ctacaagttt tgagtatgat gaaactatat catgtctgtt tgatttcata   1860

acaacataag ataatgttta ttttatcggg gtatctatgg tacagttaat ttcacgttgt   1920

gtaaatatcc acttggagac tatttgcctt gggcattttc ccctgtcatt tatgagtctc   1980

tgcaggtgta caaaaaaacc ccaatctact gtaaatggca gtttaattgt tagaaatgac   2040

tgtttttgca ccacttgtaa aaaggtattt agcgattgca tttgctgttt gttgttttat   2100

tttgctttat atatgacttg cagaggataa ccataaaatg ggtaattctc tctgaagttg   2160

aataatcacc atgactgtaa atgaggggca caattttgga ctctggcgcc aaactgagtc   2220

ataggccagt agcattacgt gtatctggtg ccaccttgct gtttagatac aaatcatacc   2280

gtcttttaaa tattttgaag cccatttcag ttaaataatg acatgtcatg gtcctttgga   2340

atcttcattt aaatgttaaa tctggaatca aaatgaagca aaaaatatct gtctcctttt   2400

cactttcttc agtacataaa tacattattt aatcaataag aattaactgt actaaatcat   2460

gtattatgct gttctagtta cagcaaacac tctttaagaa aaatatccaa tacactaaat   2520

aggtactata gtaattttta gacatggtac ccattgatat gcatttaaac cttttactgc   2580

tgtgttatgt tgataacata tataaatatt agataatgct aatgcttctg ctgctgtctt   2640

ttctgtaata ttctctttca tgctgaattt actatgacca tttataagca gtgcagttaa   2700

ctacagatag catttcagga caaaatagat gactcaaacc atttattgct taaaaaatag   2760

cttacgccat gctatgctat aagcagcttt tatgcacatt gacaaatgaa gagtaagctt   2820

cagcttgcta aaggaaactg tggaaccttt tgtaactttt ggtgatatgg aaaattattt   2880

acaaaccgtc aaagaatatg aggaagttgc tgtatgacat agtgctggca ctgatattat   2940

ccatcatctc tttttggaca cttctgtaaa tgtgattgga ttgtttgaaa gaagatttaa   3000

agtttcaaag ttttttgttc tgtttttgct ttgcatttgg agaaaatatt gaaagcaggg   3060

tatgttgttt cattcacctt gaaaaaacca tgagtaaatg gggatataga atctctgaat   3120

agctcgctaa aagattcaag caagggacat gaattttgtt ccatctatca ataatatcca   3180

gaagaacaac ttttttaaag agtctatagc aaaaagcaaa aaaaaaaaaa aattctaaac   3240

acaaagtcaa aataaaccta ttgtaaaagc atttcgtgat gagcatgaaa aagattgttt   3300

aaagatgatc cccccagcta cccattttcc aaaactacac agatcacagc tcatttctct   3360

aagtggagca gttatcaaga aacccaaaca ccaaaattgc tactcttcac atttaatcct   3420

acaaaaagta ctccaatttc aaaatatgta tgtaacctgc gatttcaatg attgttgttc   3480

atatacatca tgtattattt tggcccattt tgggcctaaa aaagaaaact atgccttaaa   3540

aatcagaacc ttttctcccc actatgctta tgtggccatc tacagcactt agaataaaaa   3600

cagatgttaa aatattcagt gaaagtttta ttggaaaaag gaattgagat atataattga   3660

gatttggtga aattgaagga gaaaatttaa gtgagtcttt aaaatatatt ctgaatgaaa   3720

actgtattga ggattcattt ttgttccttt tttttctttt tctcttttct cctttttctt   3780

ctttttaata gtctagtttt agtcagtcag tgaggaagaa ttgggccatg ctaacgttat   3840

cacaagagaa caatggcaga aatggtatta gttatataat atttaaggac aaactatatg   3900

ttttgctgtt ttaacgtagt gactcactga actaaataca taattgacca acattaagtg   3960

tatttccaat acagaagggt tgaaaatatt acattataaa ctcttttgaa aaatgtatct   4020

aaaatttttt aagttctgtt ttgattccac tttttggttg agtttttatg tttttgtttt   4080

caggtagatt aataaatctg gcagctgatt tctgcaagat tcttgtgttt tgaatttctc   4140

attgaattgg ctactcaaac atagaaatca tttgttaatg atgtaatgtc ttctctcagc   4200

ttttatcttc actgctgttt gctgtctctt gatgatgaca tgttaatacc caatagatta   4260

attgcaacaa acacttatac tcaaataact aagtaaaaat aatttttctt gttatgtcca   4320

tgaaaagtgc ttcagaataa aaatccacaa gactgacagt gcagaacatt tttctcaaat   4380

catgggcgga tcttggaggt ctagtttccc gtagatgctg taaccaatta ccacaacttc   4440

agtaatttac acaaatttat cttatagttc tggaggcaga agttcaaaag aagccttaag   4500

agactaaaac caagatgtcc ttaggtctgg ttccttctgg aggctccagg ggagattctt   4560

ccagctttca cttctagagt ctgctgacat tccttggctc ctggctacat cacttcaatc   4620

tctgcttcca tggtcacata ctcttctact atagtcaaat ttccttcctg cctcttataa   4680

ggatgcttgt gattacattt aggggatgct cagataatcc aggacaatct ctccatctca   4740

agatccttaa cttaatgacg tgtgccaagt ccctttggct agataattat tcataggtcc   4800

cagggattag gacatggatg taaggggtga gggcagggct gttattcaga acaccgcacg   4860

gaggaggaag actgtgtagc aaagactcta attgatttac tcaggaacag tggagttctg   4920

ctgagggatc taggatttga aagtactaga gtttgctttt atttaccact gagatatttt   4980

ccccttattc tgcataaata attttgaaaa ctttctatat taaatttcaa ctattccact   5040

aaaatgtctg gtaatcacat caagccttta gattattcaa atccttcccc agcccccagg   5100

aaaacactaa gtcatgaaac agaaaaacag aaggtatgat aataatagta ataacagtta   5160

aatcagtggt ctaatccaga ttttattttt taatacattt cttttggtgt taatatgggt   5220

tactatgtga tcttatcatt tgctagtgat tattacttat taggtaagaa caatgtgtaa   5280

aatatgtcta ttactcaaaa gaacaattgc aaaatgagtc aacttatctt tatataacca   5340

ggaaagaaat atattgccag aagctacaga attttgccag atgataggga tttctaaaat   5400

gagccacttt gtctatcatg cagccttttc agagcttgta atgagaaaac attacagagg   5460

agaaggtcat ttggatgttt gttacttgga atcctagaaa acaaaaacta aaatttaaaa   5520

ataagaagtg agtaagctat tttccatttg cgatttggta tggagaagag aggaaataga   5580

attattaaaa aaatacaaat tgggtaaaag tgatggtgga aaaaatataa agaaggcaaa   5640

tgtacatatt aagcaattct actaagaatt ggaaaaatca agtttcaaaa agatggtaat   5700

agttgggcat gatactagaa aatttcaccc agtttattca gagctcaact agtactttta   5760

ggacttcttt ttttatatac atgagactca ctttgacata cttaaaaaaa aaacagttta   5820

tggaaagtac agtttaagag gagaatttga ttagactaag tggatatctt tatagaaata   5880

ttaatgattt cagaattttc agttacaagt gtatataccg tggctattgt ttatggattc   5940

atatgtaagg tagggtcttt tttgcatata gactccagta ttagttactt tcattctaaa   6000

attatattta tgcttctatg gggaagaaaa tttttaattc acttggttgt attaaaatta   6060

tacttacggt ttgagaaaac atgctatgaa aatcatgatt atagcaaatt aaatatgctc   6120

aaaatttaaa tctaaaataa aagcccagaa actgaaaa                           6158


<210>  438
<211>  477
<212>  PRT
<213>  Homosapiens

<400>  438

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Tyr Met Val Thr Asn Ser 
1               5                   10                  15      


Gln Arg Gly Arg Asn Cys Asn Glu Lys Pro Thr Asn Val Arg Lys Arg 
            20                  25                  30          


Lys Phe Ile Asn Arg Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Thr Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asn Asp Glu Gln Phe Val Pro Asp Tyr Gln Ala Glu Ser Leu Ala 
65                  70                  75                  80  


Phe His Gly Leu Pro Leu Lys Ile Lys Lys Glu Pro His Ser Pro Cys 
                85                  90                  95      


Ser Glu Ile Ser Ser Ala Cys Ser Gln Glu Gln Pro Phe Lys Phe Ser 
            100                 105                 110         


Tyr Gly Glu Lys Cys Leu Tyr Asn Val Ser Ala Tyr Asp Gln Lys Pro 
        115                 120                 125             


Gln Val Gly Met Arg Pro Ser Asn Pro Pro Thr Pro Ser Ser Thr Pro 
    130                 135                 140                 


Val Ser Pro Leu His His Ala Ser Pro Asn Ser Thr His Thr Pro Lys 
145                 150                 155                 160 


Pro Asp Arg Ala Phe Pro Ala His Leu Pro Pro Ser Gln Ser Ile Pro 
                165                 170                 175     


Asp Ser Ser Tyr Pro Met Asp His Arg Phe Arg Arg Gln Leu Ser Glu 
            180                 185                 190         


Pro Cys Asn Ser Phe Pro Pro Leu Pro Thr Met Pro Arg Glu Gly Arg 
        195                 200                 205             


Pro Met Tyr Gln Arg Gln Met Ser Glu Pro Asn Ile Pro Phe Pro Pro 
    210                 215                 220                 


Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Val Tyr Glu His Asn Thr 
225                 230                 235                 240 


Met Val Gly Ser Ala Ala Ser Gln Ser Phe Pro Pro Pro Leu Met Ile 
                245                 250                 255     


Lys Gln Glu Pro Arg Asp Phe Ala Tyr Asp Ser Glu Val Pro Ser Cys 
            260                 265                 270         


His Ser Ile Tyr Met Arg Gln Glu Gly Phe Leu Ala His Pro Ser Arg 
        275                 280                 285             


Thr Glu Gly Cys Met Phe Glu Lys Gly Pro Arg Gln Phe Tyr Asp Asp 
    290                 295                 300                 


Thr Cys Val Val Pro Glu Lys Phe Asp Gly Asp Ile Lys Gln Glu Pro 
305                 310                 315                 320 


Gly Met Tyr Arg Glu Gly Pro Thr Tyr Gln Arg Arg Gly Ser Leu Gln 
                325                 330                 335     


Leu Trp Gln Phe Leu Val Ala Leu Leu Asp Asp Pro Ser Asn Ser His 
            340                 345                 350         


Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu Pro 
        355                 360                 365             


Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala Met 
    370                 375                 380                 


Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys Gly 
385                 390                 395                 400 


Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val Cys 
                405                 410                 415     


Asp Pro Glu Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg Pro 
            420                 425                 430         


Leu Leu Lys Thr Asp Met Glu Arg His Ile Asn Glu Glu Asp Thr Val 
        435                 440                 445             


Pro Leu Ser His Phe Asp Glu Ser Met Ala Tyr Met Pro Glu Gly Gly 
    450                 455                 460                 


Cys Cys Asn Pro His Pro Tyr Asn Glu Gly Tyr Val Tyr 
465                 470                 475         


<210>  439
<211>  2571
<212>  DNA
<213>  Homosapiens

<400>  439
gtgactctgc ctgcgcgcgc gccagccccg cagctctcgc cagagccttg ggatcaaggg     60

agaaagagaa ccggcagctg gcctcggact ctaagcggtg cgcagctcca gcccgagcgg    120

atcggccctg aacccacaaa ggactcctcg ctccttcaag cctccaccac ctcgcagccg    180

gggaggcaac tggagcgaaa ccagcgacag gttgtccagg ctgatcttat actcctggcc    240

tcaagtgatc ctcctgcctc agtctccaaa agcactggga atacataggt tgttagcgac    300

atgagtacag ggtctggatc ttacccattc aagagtgtat tctcagcacc caatgcctgg    360

catatagttt aaatgtttat ttgctacttg gctactgatt agagaacgca aaatgaataa    420

ctcaacaaac tcctctaaca atagcctggc tcttacaagt ccttataaga catttgaagt    480

ggtgtttatt gtcctggtgg ctggatccct cagtttggtg accattatcg ggaacatcct    540

agtcatggtt tccattaaag tcaaccgcca cctccagacc gtcaacaatt actttttatt    600

cagcttggcc tgtgctgacc ttatcatagg tgttttctcc atgaacttgt acaccctcta    660

cactgtgatt ggttactggc ctttgggacc tgtggtgtgt gacctttggc tagccctgga    720

ctatgtggtc agcaatgcct cagttatgaa tctgctcatc atcagctttg acaggtactt    780

ctgtgtcaca aaacctctga cctacccagt caagcggacc acaaaaatgg caggtatgat    840

gattgcagct gcctgggtcc tctctttcat cctctgggct ccagccattc tcttctggca    900

gttcattgta ggggtgagaa ctgtggagga tggggagtgc tacattcagt ttttttccaa    960

tgctgctgtc acctttggta cggctattgc agccttctat ttgccagtga tcatcatgac   1020

tgtgctatat tggcacatat cccgagccag caagagcagg ataaagaagg acaagaagga   1080

gcctgttgcc aaccaagacc ccgtttctcc aagtctggta caaggaagga tagtgaagcc   1140

aaacaataac aacatgccca gcagtgacga tggcctggag cacaacaaaa tccagaatgg   1200

caaagccccc agggatcctg tgactgaaaa ctgtgttcag ggagaggaga aggagagctc   1260

caatgactcc acctcagtca gtgctgttgc ctctaatatg agagatgatg aaataaccca   1320

ggatgaaaac acagtttcca cttccctggg ccattccaaa gatgagaact ctaagcaaac   1380

atgcatcaga attggcacca agaccccaaa aagtgactca tgtaccccaa ctaataccac   1440

cgtggaggta gtggggtctt caggtcagaa tggagatgaa aagcagaata ttgtagcccg   1500

caagattgtg aagatgacta agcagcctgc aaaaaagaag cctcctcctt cccgggaaaa   1560

gaaagtcacc aggacaatct tggctattct gttggctttc atcatcactt gggccccata   1620

caatgtcatg gtgctcatta acaccttttg tgcaccttgc atccccaaca ctgtgtggac   1680

aattggttac tggctttgtt acatcaacag cactatcaac cctgcctgct atgcactttg   1740

caatgccacc ttcaagaaga cctttaaaca ccttctcatg tgtcattata agaacatagg   1800

cgctacaagg taaaatatct ttgaaaaaga tagaaggtgg gcaaggggag cttgagaaga   1860

ataaaaggga taaacgagct cctagtttta aaatctctgc cattgcactt tatagtctga   1920

ttacaaaacg tgcaattcag gagcccagca gtgacacact tatcacgcct aggctccagt   1980

ttgcaaaaat tgcaccttat aaactgtcag tattaggagc aatgagacaa tgaaagaaac   2040

atgttgggat cgtggattta agaaactata cactgtttct cataatctct tgaagaaggg   2100

cttctgattc tacaatttta tcagtctctg cacaagagga ataaccttgt tccttttttg   2160

ttacttttgt tgttgttgtt ctcatgtgtc cttaagagaa ggaaatgcca cagttacaag   2220

gtaaacatgg agacttaaac ataaagaaat aggcactata caatggggac ataaaaaaag   2280

aaaatcaaag aaggatgcag aaattgtctc cggagtgtta agcatatttt attcttttgt   2340

tacggtccta tttagaggat tggaatgtaa taaatgctta ttttttgcct ttctttttcc   2400

caccatgaag agaaagcaaa caaacagaaa ccccaactag gtcacaccat ttttcttctt   2460

gttatgccac tattttgtac atccctgttc tatattgttt atagggaaaa cctacaggac   2520

tttcactaaa gctagccaga gacagccatg aaaatggacg tttcacccct c            2571


<210>  440
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  440

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  441
<211>  2456
<212>  DNA
<213>  Homosapiens

<400>  441
cttttctttt gcaagatcaa gggagaaaga gaaccggcag ctggcctcgg actctaagcg     60

gtgcgcagct ccagcccgag cggatcggcc ctgaacccac aaaggactcc tcgctccttc    120

aagcctccac cacctcgcag ccggggaggc aactggagcg aaaccagcga caggttgtta    180

gcgacatgag tacagggtct ggatcttacc cattcaagag tgtattctca gcacccaatg    240

cctggcatat agtttaaatg tttatttgct acttggctac tgattagaga acgcaaaatg    300

aataactcaa caaactcctc taacaatagc ctggctctta caagtcctta taagacattt    360

gaagtggtgt ttattgtcct ggtggctgga tccctcagtt tggtgaccat tatcgggaac    420

atcctagtca tggtttccat taaagtcaac cgccacctcc agaccgtcaa caattacttt    480

ttattcagct tggcctgtgc tgaccttatc ataggtgttt tctccatgaa cttgtacacc    540

ctctacactg tgattggtta ctggcctttg ggacctgtgg tgtgtgacct ttggctagcc    600

ctggactatg tggtcagcaa tgcctcagtt atgaatctgc tcatcatcag ctttgacagg    660

tacttctgtg tcacaaaacc tctgacctac ccagtcaagc ggaccacaaa aatggcaggt    720

atgatgattg cagctgcctg ggtcctctct ttcatcctct gggctccagc cattctcttc    780

tggcagttca ttgtaggggt gagaactgtg gaggatgggg agtgctacat tcagtttttt    840

tccaatgctg ctgtcacctt tggtacggct attgcagcct tctatttgcc agtgatcatc    900

atgactgtgc tatattggca catatcccga gccagcaaga gcaggataaa gaaggacaag    960

aaggagcctg ttgccaacca agaccccgtt tctccaagtc tggtacaagg aaggatagtg   1020

aagccaaaca ataacaacat gcccagcagt gacgatggcc tggagcacaa caaaatccag   1080

aatggcaaag cccccaggga tcctgtgact gaaaactgtg ttcagggaga ggagaaggag   1140

agctccaatg actccacctc agtcagtgct gttgcctcta atatgagaga tgatgaaata   1200

acccaggatg aaaacacagt ttccacttcc ctgggccatt ccaaagatga gaactctaag   1260

caaacatgca tcagaattgg caccaagacc ccaaaaagtg actcatgtac cccaactaat   1320

accaccgtgg aggtagtggg gtcttcaggt cagaatggag atgaaaagca gaatattgta   1380

gcccgcaaga ttgtgaagat gactaagcag cctgcaaaaa agaagcctcc tccttcccgg   1440

gaaaagaaag tcaccaggac aatcttggct attctgttgg ctttcatcat cacttgggcc   1500

ccatacaatg tcatggtgct cattaacacc ttttgtgcac cttgcatccc caacactgtg   1560

tggacaattg gttactggct ttgttacatc aacagcacta tcaaccctgc ctgctatgca   1620

ctttgcaatg ccaccttcaa gaagaccttt aaacaccttc tcatgtgtca ttataagaac   1680

ataggcgcta caaggtaaaa tatctttgaa aaagatagaa ggtgggcaag gggagcttga   1740

gaagaataaa agggataaac gagctcctag ttttaaaatc tctgccattg cactttatag   1800

tctgattaca aaacgtgcaa ttcaggagcc cagcagtgac acacttatca cgcctaggct   1860

ccagtttgca aaaattgcac cttataaact gtcagtatta ggagcaatga gacaatgaaa   1920

gaaacatgtt gggatcgtgg atttaagaaa ctatacactg tttctcataa tctcttgaag   1980

aagggcttct gattctacaa ttttatcagt ctctgcacaa gaggaataac cttgttcctt   2040

ttttgttact tttgttgttg ttgttctcat gtgtccttaa gagaaggaaa tgccacagtt   2100

acaaggtaaa catggagact taaacataaa gaaataggca ctatacaatg gggacataaa   2160

aaaagaaaat caaagaagga tgcagaaatt gtctccggag tgttaagcat attttattct   2220

tttgttacgg tcctatttag aggattggaa tgtaataaat gcttattttt tgcctttctt   2280

tttcccacca tgaagagaaa gcaaacaaac agaaacccca actaggtcac accatttttc   2340

ttcttgttat gccactattt tgtacatccc tgttctatat tgtttatagg gaaaacctac   2400

aggactttca ctaaagctag ccagagacag ccatgaaaat ggacgtttca cccctc       2456


<210>  442
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  442

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  443
<211>  2474
<212>  DNA
<213>  Homosapiens

<400>  443
acagactagc caagtggctg agacgagtgt gggatcaagg gagaaagaga accggcagct     60

ggcctcggac tctaagcggt gcgcagctcc agcccgagcg gatcggccct gaacccacaa    120

aggactcctc gctccttcaa gcctccacca cctcgcagcc ggggaggcaa ctggagcgaa    180

accagcgaca ggttgttagc gacatgagta cagggtctgg atcttaccca ttcaagagtg    240

tattctcagc acccaatgcc tggcatatag tttaaatgtt tatttgctac ttggctactg    300

attagagaac gcaaaatgaa taactcaaca aactcctcta acaatagcct ggctcttaca    360

agtccttata agacatttga agtggtgttt attgtcctgg tggctggatc cctcagtttg    420

gtgaccatta tcgggaacat cctagtcatg gtttccatta aagtcaaccg ccacctccag    480

accgtcaaca attacttttt attcagcttg gcctgtgctg accttatcat aggtgttttc    540

tccatgaact tgtacaccct ctacactgtg attggttact ggcctttggg acctgtggtg    600

tgtgaccttt ggctagccct ggactatgtg gtcagcaatg cctcagttat gaatctgctc    660

atcatcagct ttgacaggta cttctgtgtc acaaaacctc tgacctaccc agtcaagcgg    720

accacaaaaa tggcaggtat gatgattgca gctgcctggg tcctctcttt catcctctgg    780

gctccagcca ttctcttctg gcagttcatt gtaggggtga gaactgtgga ggatggggag    840

tgctacattc agtttttttc caatgctgct gtcacctttg gtacggctat tgcagccttc    900

tatttgccag tgatcatcat gactgtgcta tattggcaca tatcccgagc cagcaagagc    960

aggataaaga aggacaagaa ggagcctgtt gccaaccaag accccgtttc tccaagtctg   1020

gtacaaggaa ggatagtgaa gccaaacaat aacaacatgc ccagcagtga cgatggcctg   1080

gagcacaaca aaatccagaa tggcaaagcc cccagggatc ctgtgactga aaactgtgtt   1140

cagggagagg agaaggagag ctccaatgac tccacctcag tcagtgctgt tgcctctaat   1200

atgagagatg atgaaataac ccaggatgaa aacacagttt ccacttccct gggccattcc   1260

aaagatgaga actctaagca aacatgcatc agaattggca ccaagacccc aaaaagtgac   1320

tcatgtaccc caactaatac caccgtggag gtagtggggt cttcaggtca gaatggagat   1380

gaaaagcaga atattgtagc ccgcaagatt gtgaagatga ctaagcagcc tgcaaaaaag   1440

aagcctcctc cttcccggga aaagaaagtc accaggacaa tcttggctat tctgttggct   1500

ttcatcatca cttgggcccc atacaatgtc atggtgctca ttaacacctt ttgtgcacct   1560

tgcatcccca acactgtgtg gacaattggt tactggcttt gttacatcaa cagcactatc   1620

aaccctgcct gctatgcact ttgcaatgcc accttcaaga agacctttaa acaccttctc   1680

atgtgtcatt ataagaacat aggcgctaca aggtaaaata tctttgaaaa agatagaagg   1740

tgggcaaggg gagcttgaga agaataaaag ggataaacga gctcctagtt ttaaaatctc   1800

tgccattgca ctttatagtc tgattacaaa acgtgcaatt caggagccca gcagtgacac   1860

acttatcacg cctaggctcc agtttgcaaa aattgcacct tataaactgt cagtattagg   1920

agcaatgaga caatgaaaga aacatgttgg gatcgtggat ttaagaaact atacactgtt   1980

tctcataatc tcttgaagaa gggcttctga ttctacaatt ttatcagtct ctgcacaaga   2040

ggaataacct tgttcctttt ttgttacttt tgttgttgtt gttctcatgt gtccttaaga   2100

gaaggaaatg ccacagttac aaggtaaaca tggagactta aacataaaga aataggcact   2160

atacaatggg gacataaaaa aagaaaatca aagaaggatg cagaaattgt ctccggagtg   2220

ttaagcatat tttattcttt tgttacggtc ctatttagag gattggaatg taataaatgc   2280

ttattttttg cctttctttt tcccaccatg aagagaaagc aaacaaacag aaaccccaac   2340

taggtcacac catttttctt cttgttatgc cactattttg tacatccctg ttctatattg   2400

tttataggga aaacctacag gactttcact aaagctagcc agagacagcc atgaaaatgg   2460

acgtttcacc cctc                                                     2474


<210>  444
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  444

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  445
<211>  2452
<212>  DNA
<213>  Homosapiens

<400>  445
acagactagc caagtggctg agacgagtgt ggggtgcgtg actctgcctg cgcgcgcgcc     60

agccccgcag ctctcgccag agccttggga tcaagggaga aagagaaccg gcagctggcc    120

tcggactcta agcggtgcgc agctccagcc cgagcggatc ggccctgaac ccacaaagga    180

ctcctcgctc cttcaagcct ccaccacctc gcagccgggg aggcaactgg agcgaaacca    240

gcgacaggtt taaatgttta tttgctactt ggctactgat tagagaacgc aaaatgaata    300

actcaacaaa ctcctctaac aatagcctgg ctcttacaag tccttataag acatttgaag    360

tggtgtttat tgtcctggtg gctggatccc tcagtttggt gaccattatc gggaacatcc    420

tagtcatggt ttccattaaa gtcaaccgcc acctccagac cgtcaacaat tactttttat    480

tcagcttggc ctgtgctgac cttatcatag gtgttttctc catgaacttg tacaccctct    540

acactgtgat tggttactgg cctttgggac ctgtggtgtg tgacctttgg ctagccctgg    600

actatgtggt cagcaatgcc tcagttatga atctgctcat catcagcttt gacaggtact    660

tctgtgtcac aaaacctctg acctacccag tcaagcggac cacaaaaatg gcaggtatga    720

tgattgcagc tgcctgggtc ctctctttca tcctctgggc tccagccatt ctcttctggc    780

agttcattgt aggggtgaga actgtggagg atggggagtg ctacattcag tttttttcca    840

atgctgctgt cacctttggt acggctattg cagccttcta tttgccagtg atcatcatga    900

ctgtgctata ttggcacata tcccgagcca gcaagagcag gataaagaag gacaagaagg    960

agcctgttgc caaccaagac cccgtttctc caagtctggt acaaggaagg atagtgaagc   1020

caaacaataa caacatgccc agcagtgacg atggcctgga gcacaacaaa atccagaatg   1080

gcaaagcccc cagggatcct gtgactgaaa actgtgttca gggagaggag aaggagagct   1140

ccaatgactc cacctcagtc agtgctgttg cctctaatat gagagatgat gaaataaccc   1200

aggatgaaaa cacagtttcc acttccctgg gccattccaa agatgagaac tctaagcaaa   1260

catgcatcag aattggcacc aagaccccaa aaagtgactc atgtacccca actaatacca   1320

ccgtggaggt agtggggtct tcaggtcaga atggagatga aaagcagaat attgtagccc   1380

gcaagattgt gaagatgact aagcagcctg caaaaaagaa gcctcctcct tcccgggaaa   1440

agaaagtcac caggacaatc ttggctattc tgttggcttt catcatcact tgggccccat   1500

acaatgtcat ggtgctcatt aacacctttt gtgcaccttg catccccaac actgtgtgga   1560

caattggtta ctggctttgt tacatcaaca gcactatcaa ccctgcctgc tatgcacttt   1620

gcaatgccac cttcaagaag acctttaaac accttctcat gtgtcattat aagaacatag   1680

gcgctacaag gtaaaatatc tttgaaaaag atagaaggtg ggcaagggga gcttgagaag   1740

aataaaaggg ataaacgagc tcctagtttt aaaatctctg ccattgcact ttatagtctg   1800

attacaaaac gtgcaattca ggagcccagc agtgacacac ttatcacgcc taggctccag   1860

tttgcaaaaa ttgcacctta taaactgtca gtattaggag caatgagaca atgaaagaaa   1920

catgttggga tcgtggattt aagaaactat acactgtttc tcataatctc ttgaagaagg   1980

gcttctgatt ctacaatttt atcagtctct gcacaagagg aataaccttg ttcctttttt   2040

gttacttttg ttgttgttgt tctcatgtgt ccttaagaga aggaaatgcc acagttacaa   2100

ggtaaacatg gagacttaaa cataaagaaa taggcactat acaatgggga cataaaaaaa   2160

gaaaatcaaa gaaggatgca gaaattgtct ccggagtgtt aagcatattt tattcttttg   2220

ttacggtcct atttagagga ttggaatgta ataaatgctt attttttgcc tttctttttc   2280

ccaccatgaa gagaaagcaa acaaacagaa accccaacta ggtcacacca tttttcttct   2340

tgttatgcca ctattttgta catccctgtt ctatattgtt tatagggaaa acctacagga   2400

ctttcactaa agctagccag agacagccat gaaaatggac gtttcacccc tc           2452


<210>  446
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  446

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  447
<211>  2406
<212>  DNA
<213>  Homosapiens

<400>  447
acagactagc caagtggctg agacgagtgt ggggtgcgtg actctgcctg cgcgcgcgcc     60

agccccgcag ctctcgccag agccttggga tcaagggaga aagagaaccg gcagctggcc    120

tcggactcta agcggtgcgc agctccagcc cgagcggatc ggccctgaac ccacaaagga    180

ctcctcgctc cttcaagcct ccaccacctc gcagccgggg aggcaactgg agcgaaacca    240

gcgacagatg cagccatgga caagacaagg agagcttcgt ccctcccgcc cctcgggttc    300

cttcctgctg gggtctgacc gcgtcttctg tgcgtgtggg atggaggccc ggctcgctcg    360

ggctccgagc tgtcccccgg ctccgctttc ggagcagccc ttgggcgctg gagaggtttc    420

ccattgcggt ctccaggtca tggccaagga ggagaagcaa ttagaatggg ggaaagggtc    480

ccaagacaaa ggagagggaa gcattctgca atcccatcct atttgagccc cgcgcaggag    540

ctggactgtc cgccgtggct gggggacaag gtctcagccc gaagctcatg aggtaccaga    600

cagtgcctgg gcttcgccac ctaactcaca atgggtcctg aaccgcccgg gcagtccccg    660

gggtcgtaga ctggggaccg ctgcacccct ccccgcccgc aatgtccctt ggagtccgca    720

cctgaggtcc caggcaatcg ccgctaactt gtagctctcg gacacggaca ggtgcggtcc    780

atgcctggtg ccggtagacg cgcagaaatt ccacctgtgc gcgctgcccg gcgcccctgg    840

ggcccctcac ggggtaagta gagactcatc tgggagaggt gaaaattccc cagaattatt    900

gacacacacg gcggcacacc ctttgcctcc gtccgcctcc agcatccgca tccctttctc    960

tatcttcctg cccattgccg tcctcgaggc tgccctgaga tacagaattg tcccaggctg   1020

agtccaccga cccgccagtc cctggcgatg atgccaaggc tcttgcatgt acggaaatac   1080

cagcagggag gttcgccagg ggcagagagg ctggaggaga acagagaatt ggaggtaaac   1140

gcgtaaagcc agcagaactg tcggtggaca tttcacccag gccgccctcc cgcgtcttta   1200

agtcagttca ccgccacagc acgtctgtga ctgcggccac ccagggctcc aagtctgcca   1260

gcccaggcgc cgcgagccaa gaagagcgcg gcgcctccca ctcctcaagc tccggaatcc   1320

cccacatcga ctttctattt ccctgtcttc ttttcttttt tgtttgtttt gcttttcctg   1380

ctcttttctt agcgctgggt ggcagtgggt atgcggcagc cgtgtgattt gcccatcccc   1440

tagtacacgc agccagcgac acaagcacac agcgaccagt ccccacgctg tgccacacac   1500

cctccagcgg tccggcgcgc agcccctgct ccacagcccg ggacgcctgc agccaccgcc   1560

agggtcatgg ccatggccca cgcagggctc tgcgggtgga gaggggaagt cagcctagac   1620

tccagagaga aaccctgggg caacccgaaa ggcctgagga aaactggaat tggggttagg   1680

catgagggga gggagtctct ggggaaaacg ggccgggctg tgcggagccc tgagggctcc   1740

tgcggctgca gcgctgcagg ccgcccgcgt ctcgccccgc cccgccgctg ggcgtccccg   1800

ccaggagccc acccgcgggc ggcagctttt ctccatgctg cccagggaag ttcgatgcct   1860

ggtgctggga tgcgccagcg cttctgttcg cttctggcaa tcctggcgtc tcccaatgag   1920

agggctctca aaatgaagct tttaataaac tccagagtaa ggaactcggg attgtgcggc   1980

aaaggccgcg cattgcactt tgtgagcaat cggtaaatat gcgcaaccat atgataggaa   2040

atatatgcat tttcattgat aagaaaaaaa gagatgatgg tatttttaaa cagaagccac   2100

aaacaggcat acctgtgcca ttgttgggga gctaataata aaggcactga tgatcacagg   2160

agtaagaaca attgacttgg ccaagagaca attttaagct gggaactgta ttcggctgca   2220

gttcagaaag tggacttttg agacttgtca aacgaatgga agaattttgt gccaacaatg   2280

tcccagcttt gcaggcttgg cagctgagga ctcagaagta acaaattaat gccaggtgaa   2340

ttattattgt tactactatt atcaaaatgt gttccagttg cagcaataca atggataagc   2400

aacttc                                                              2406


<210>  448
<211>  149
<212>  PRT
<213>  Homosapiens

<400>  448

Met Ala Met Ala His Ala Gly Leu Cys Gly Trp Arg Gly Glu Val Ser 
1               5                   10                  15      


Leu Asp Ser Arg Glu Lys Pro Trp Gly Asn Pro Lys Gly Leu Arg Lys 
            20                  25                  30          


Thr Gly Ile Gly Val Arg His Glu Gly Arg Glu Ser Leu Gly Lys Thr 
        35                  40                  45              


Gly Arg Ala Val Arg Ser Pro Glu Gly Ser Cys Gly Cys Ser Ala Ala 
    50                  55                  60                  


Gly Arg Pro Arg Leu Ala Pro Pro Arg Arg Trp Ala Ser Pro Pro Gly 
65                  70                  75                  80  


Ala His Pro Arg Ala Ala Ala Phe Leu His Ala Ala Gln Gly Ser Ser 
                85                  90                  95      


Met Pro Gly Ala Gly Met Arg Gln Arg Phe Cys Ser Leu Leu Ala Ile 
            100                 105                 110         


Leu Ala Ser Pro Asn Glu Arg Ala Leu Lys Met Lys Leu Leu Ile Asn 
        115                 120                 125             


Ser Arg Val Arg Asn Ser Gly Leu Cys Gly Lys Gly Arg Ala Leu His 
    130                 135                 140                 


Phe Val Ser Asn Arg 
145                 


<210>  449
<211>  2530
<212>  DNA
<213>  Homosapiens

<400>  449
acagactagc caagtggctg agacgagtgt ggggtgcgtg actctgcctg cgcgcgcgcc     60

agccccgcag ctctcgccag agccttggga tcaagggaga aagagaaccg gcagctggcc    120

tcggactcta agcggtgcgc agctccagcc cgagcggatc ggccctgaac ccacaaagga    180

ctcctcgctc cttcaagcct ccaccacctc gcagccgggg aggcaactgg agcgaaacca    240

gcgacaggtt gttagcgaca tgagtacagg gtctggatct tacccattca agagtgtatt    300

ctcagcaccc aatgcctggc atatagttta aatgtttatt tgctacttgg ctactgatta    360

gagaacgcaa aatgaataac tcaacaaact cctctaacaa tagcctggct cttacaagtc    420

cttataagac atttgaagtg gtgtttattg tcctggtggc tggatccctc agtttggtga    480

ccattatcgg gaacatccta gtcatggttt ccattaaagt caaccgccac ctccagaccg    540

tcaacaatta ctttttattc agcttggcct gtgctgacct tatcataggt gttttctcca    600

tgaacttgta caccctctac actgtgattg gttactggcc tttgggacct gtggtgtgtg    660

acctttggct agccctggac tatgtggtca gcaatgcctc agttatgaat ctgctcatca    720

tcagctttga caggtacttc tgtgtcacaa aacctctgac ctacccagtc aagcggacca    780

caaaaatggc aggtatgatg attgcagctg cctgggtcct ctctttcatc ctctgggctc    840

cagccattct cttctggcag ttcattgtag gggtgagaac tgtggaggat ggggagtgct    900

acattcagtt tttttccaat gctgctgtca cctttggtac ggctattgca gccttctatt    960

tgccagtgat catcatgact gtgctatatt ggcacatatc ccgagccagc aagagcagga   1020

taaagaagga caagaaggag cctgttgcca accaagaccc cgtttctcca agtctggtac   1080

aaggaaggat agtgaagcca aacaataaca acatgcccag cagtgacgat ggcctggagc   1140

acaacaaaat ccagaatggc aaagccccca gggatcctgt gactgaaaac tgtgttcagg   1200

gagaggagaa ggagagctcc aatgactcca cctcagtcag tgctgttgcc tctaatatga   1260

gagatgatga aataacccag gatgaaaaca cagtttccac ttccctgggc cattccaaag   1320

atgagaactc taagcaaaca tgcatcagaa ttggcaccaa gaccccaaaa agtgactcat   1380

gtaccccaac taataccacc gtggaggtag tggggtcttc aggtcagaat ggagatgaaa   1440

agcagaatat tgtagcccgc aagattgtga agatgactaa gcagcctgca aaaaagaagc   1500

ctcctccttc ccgggaaaag aaagtcacca ggacaatctt ggctattctg ttggctttca   1560

tcatcacttg ggccccatac aatgtcatgg tgctcattaa caccttttgt gcaccttgca   1620

tccccaacac tgtgtggaca attggttact ggctttgtta catcaacagc actatcaacc   1680

ctgcctgcta tgcactttgc aatgccacct tcaagaagac ctttaaacac cttctcatgt   1740

gtcattataa gaacataggc gctacaaggt aaaatatctt tgaaaaagat agaaggtggg   1800

caaggggagc ttgagaagaa taaaagggat aaacgagctc ctagttttaa aatctctgcc   1860

attgcacttt atagtctgat tacaaaacgt gcaattcagg agcccagcag tgacacactt   1920

atcacgccta ggctccagtt tgcaaaaatt gcaccttata aactgtcagt attaggagca   1980

atgagacaat gaaagaaaca tgttgggatc gtggatttaa gaaactatac actgtttctc   2040

ataatctctt gaagaagggc ttctgattct acaattttat cagtctctgc acaagaggaa   2100

taaccttgtt ccttttttgt tacttttgtt gttgttgttc tcatgtgtcc ttaagagaag   2160

gaaatgccac agttacaagg taaacatgga gacttaaaca taaagaaata ggcactatac   2220

aatggggaca taaaaaaaga aaatcaaaga aggatgcaga aattgtctcc ggagtgttaa   2280

gcatatttta ttcttttgtt acggtcctat ttagaggatt ggaatgtaat aaatgcttat   2340

tttttgcctt tctttttccc accatgaaga gaaagcaaac aaacagaaac cccaactagg   2400

tcacaccatt tttcttcttg ttatgccact attttgtaca tccctgttct atattgttta   2460

tagggaaaac ctacaggact ttcactaaag ctagccagag acagccatga aaatggacgt   2520

ttcacccctc                                                          2530


<210>  450
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  450

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  451
<211>  2704
<212>  DNA
<213>  Homosapiens

<400>  451
attgcagcta atcgaacaca cacgcacgaa tacagacacg ctctcctgct gtactaaagg     60

cgccagggcg caaagaccta gggagcgcgc gcgggcacac acacacacac acacacacac    120

acagacacac acacactcac acactccagg ctgcgggttg gccagagcct ggaaatcgca    180

gatttcacca ggaaatcgcc gaggtacccg aataggtgtt gcctcccaaa actaattcct    240

acttccccaa gcactttggt gaagaaatga atccagccca gctcgccgag gcatccaggt    300

ctccattcta ttttggtctc caggctcttc gtgaaagcca gatcaaggga gaaagagaac    360

cggcagctgg cctcggactc taagcggtgc gcagctccag cccgagcgga tcggccctga    420

acccacaaag gactcctcgc tccttcaagc ctccaccacc tcgcagccgg ggaggcaact    480

ggagcgaaac cagcgacagg tttaaatgtt tatttgctac ttggctactg attagagaac    540

gcaaaatgaa taactcaaca aactcctcta acaatagcct ggctcttaca agtccttata    600

agacatttga agtggtgttt attgtcctgg tggctggatc cctcagtttg gtgaccatta    660

tcgggaacat cctagtcatg gtttccatta aagtcaaccg ccacctccag accgtcaaca    720

attacttttt attcagcttg gcctgtgctg accttatcat aggtgttttc tccatgaact    780

tgtacaccct ctacactgtg attggttact ggcctttggg acctgtggtg tgtgaccttt    840

ggctagccct ggactatgtg gtcagcaatg cctcagttat gaatctgctc atcatcagct    900

ttgacaggta cttctgtgtc acaaaacctc tgacctaccc agtcaagcgg accacaaaaa    960

tggcaggtat gatgattgca gctgcctggg tcctctcttt catcctctgg gctccagcca   1020

ttctcttctg gcagttcatt gtaggggtga gaactgtgga ggatggggag tgctacattc   1080

agtttttttc caatgctgct gtcacctttg gtacggctat tgcagccttc tatttgccag   1140

tgatcatcat gactgtgcta tattggcaca tatcccgagc cagcaagagc aggataaaga   1200

aggacaagaa ggagcctgtt gccaaccaag accccgtttc tccaagtctg gtacaaggaa   1260

ggatagtgaa gccaaacaat aacaacatgc ccagcagtga cgatggcctg gagcacaaca   1320

aaatccagaa tggcaaagcc cccagggatc ctgtgactga aaactgtgtt cagggagagg   1380

agaaggagag ctccaatgac tccacctcag tcagtgctgt tgcctctaat atgagagatg   1440

atgaaataac ccaggatgaa aacacagttt ccacttccct gggccattcc aaagatgaga   1500

actctaagca aacatgcatc agaattggca ccaagacccc aaaaagtgac tcatgtaccc   1560

caactaatac caccgtggag gtagtggggt cttcaggtca gaatggagat gaaaagcaga   1620

atattgtagc ccgcaagatt gtgaagatga ctaagcagcc tgcaaaaaag aagcctcctc   1680

cttcccggga aaagaaagtc accaggacaa tcttggctat tctgttggct ttcatcatca   1740

cttgggcccc atacaatgtc atggtgctca ttaacacctt ttgtgcacct tgcatcccca   1800

acactgtgtg gacaattggt tactggcttt gttacatcaa cagcactatc aaccctgcct   1860

gctatgcact ttgcaatgcc accttcaaga agacctttaa acaccttctc atgtgtcatt   1920

ataagaacat aggcgctaca aggtaaaata tctttgaaaa agatagaagg tgggcaaggg   1980

gagcttgaga agaataaaag ggataaacga gctcctagtt ttaaaatctc tgccattgca   2040

ctttatagtc tgattacaaa acgtgcaatt caggagccca gcagtgacac acttatcacg   2100

cctaggctcc agtttgcaaa aattgcacct tataaactgt cagtattagg agcaatgaga   2160

caatgaaaga aacatgttgg gatcgtggat ttaagaaact atacactgtt tctcataatc   2220

tcttgaagaa gggcttctga ttctacaatt ttatcagtct ctgcacaaga ggaataacct   2280

tgttcctttt ttgttacttt tgttgttgtt gttctcatgt gtccttaaga gaaggaaatg   2340

ccacagttac aaggtaaaca tggagactta aacataaaga aataggcact atacaatggg   2400

gacataaaaa aagaaaatca aagaaggatg cagaaattgt ctccggagtg ttaagcatat   2460

tttattcttt tgttacggtc ctatttagag gattggaatg taataaatgc ttattttttg   2520

cctttctttt tcccaccatg aagagaaagc aaacaaacag aaaccccaac taggtcacac   2580

catttttctt cttgttatgc cactattttg tacatccctg ttctatattg tttataggga   2640

aaacctacag gactttcact aaagctagcc agagacagcc atgaaaatgg acgtttcacc   2700

cctc                                                                2704


<210>  452
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  452

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  453
<211>  2387
<212>  DNA
<213>  Homosapiens

<400>  453
aatcttttcc ttttcttttg caagatcaag ggagaaagag aaccggcagc tggcctcgga     60

ctctaagcgg tgcgcagctc cagcccgagc ggatcggccc tgaacccaca aaggactcct    120

cgctccttca agcctccacc acctcgcagc cggggaggca actggagcga aaccagcgac    180

aggtttaaat gtttatttgc tacttggcta ctgattagag aacgcaaaat gaataactca    240

acaaactcct ctaacaatag cctggctctt acaagtcctt ataagacatt tgaagtggtg    300

tttattgtcc tggtggctgg atccctcagt ttggtgacca ttatcgggaa catcctagtc    360

atggtttcca ttaaagtcaa ccgccacctc cagaccgtca acaattactt tttattcagc    420

ttggcctgtg ctgaccttat cataggtgtt ttctccatga acttgtacac cctctacact    480

gtgattggtt actggccttt gggacctgtg gtgtgtgacc tttggctagc cctggactat    540

gtggtcagca atgcctcagt tatgaatctg ctcatcatca gctttgacag gtacttctgt    600

gtcacaaaac ctctgaccta cccagtcaag cggaccacaa aaatggcagg tatgatgatt    660

gcagctgcct gggtcctctc tttcatcctc tgggctccag ccattctctt ctggcagttc    720

attgtagggg tgagaactgt ggaggatggg gagtgctaca ttcagttttt ttccaatgct    780

gctgtcacct ttggtacggc tattgcagcc ttctatttgc cagtgatcat catgactgtg    840

ctatattggc acatatcccg agccagcaag agcaggataa agaaggacaa gaaggagcct    900

gttgccaacc aagaccccgt ttctccaagt ctggtacaag gaaggatagt gaagccaaac    960

aataacaaca tgcccagcag tgacgatggc ctggagcaca acaaaatcca gaatggcaaa   1020

gcccccaggg atcctgtgac tgaaaactgt gttcagggag aggagaagga gagctccaat   1080

gactccacct cagtcagtgc tgttgcctct aatatgagag atgatgaaat aacccaggat   1140

gaaaacacag tttccacttc cctgggccat tccaaagatg agaactctaa gcaaacatgc   1200

atcagaattg gcaccaagac cccaaaaagt gactcatgta ccccaactaa taccaccgtg   1260

gaggtagtgg ggtcttcagg tcagaatgga gatgaaaagc agaatattgt agcccgcaag   1320

attgtgaaga tgactaagca gcctgcaaaa aagaagcctc ctccttcccg ggaaaagaaa   1380

gtcaccagga caatcttggc tattctgttg gctttcatca tcacttgggc cccatacaat   1440

gtcatggtgc tcattaacac cttttgtgca ccttgcatcc ccaacactgt gtggacaatt   1500

ggttactggc tttgttacat caacagcact atcaaccctg cctgctatgc actttgcaat   1560

gccaccttca agaagacctt taaacacctt ctcatgtgtc attataagaa cataggcgct   1620

acaaggtaaa atatctttga aaaagataga aggtgggcaa ggggagcttg agaagaataa   1680

aagggataaa cgagctccta gttttaaaat ctctgccatt gcactttata gtctgattac   1740

aaaacgtgca attcaggagc ccagcagtga cacacttatc acgcctaggc tccagtttgc   1800

aaaaattgca ccttataaac tgtcagtatt aggagcaatg agacaatgaa agaaacatgt   1860

tgggatcgtg gatttaagaa actatacact gtttctcata atctcttgaa gaagggcttc   1920

tgattctaca attttatcag tctctgcaca agaggaataa ccttgttcct tttttgttac   1980

ttttgttgtt gttgttctca tgtgtcctta agagaaggaa atgccacagt tacaaggtaa   2040

acatggagac ttaaacataa agaaataggc actatacaat ggggacataa aaaaagaaaa   2100

tcaaagaagg atgcagaaat tgtctccgga gtgttaagca tattttattc ttttgttacg   2160

gtcctattta gaggattgga atgtaataaa tgcttatttt ttgcctttct ttttcccacc   2220

atgaagagaa agcaaacaaa cagaaacccc aactaggtca caccattttt cttcttgtta   2280

tgccactatt ttgtacatcc ctgttctata ttgtttatag ggaaaaccta caggactttc   2340

actaaagcta gccagagaca gccatgaaaa tggacgtttc acccctc                 2387


<210>  454
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  454

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  455
<211>  2782
<212>  DNA
<213>  Homosapiens

<400>  455
attgcagcta atcgaacaca cacgcacgaa tacagacacg ctctcctgct gtactaaagg     60

cgccagggcg caaagaccta gggagcgcgc gcgggcacac acacacacac acacacacac    120

acagacacac acacactcac acactccagg ctgcgggttg gccagagcct ggaaatcgca    180

gatttcacca ggaaatcgcc gaggtacccg aataggtgtt gcctcccaaa actaattcct    240

acttccccaa gcactttggt gaagaaatga atccagccca gctcgccgag gcatccaggt    300

ctccattcta ttttggtctc caggctcttc gtgaaagcca gatcaaggga gaaagagaac    360

cggcagctgg cctcggactc taagcggtgc gcagctccag cccgagcgga tcggccctga    420

acccacaaag gactcctcgc tccttcaagc ctccaccacc tcgcagccgg ggaggcaact    480

ggagcgaaac cagcgacagg ttgttagcga catgagtaca gggtctggat cttacccatt    540

caagagtgta ttctcagcac ccaatgcctg gcatatagtt taaatgttta tttgctactt    600

ggctactgat tagagaacgc aaaatgaata actcaacaaa ctcctctaac aatagcctgg    660

ctcttacaag tccttataag acatttgaag tggtgtttat tgtcctggtg gctggatccc    720

tcagtttggt gaccattatc gggaacatcc tagtcatggt ttccattaaa gtcaaccgcc    780

acctccagac cgtcaacaat tactttttat tcagcttggc ctgtgctgac cttatcatag    840

gtgttttctc catgaacttg tacaccctct acactgtgat tggttactgg cctttgggac    900

ctgtggtgtg tgacctttgg ctagccctgg actatgtggt cagcaatgcc tcagttatga    960

atctgctcat catcagcttt gacaggtact tctgtgtcac aaaacctctg acctacccag   1020

tcaagcggac cacaaaaatg gcaggtatga tgattgcagc tgcctgggtc ctctctttca   1080

tcctctgggc tccagccatt ctcttctggc agttcattgt aggggtgaga actgtggagg   1140

atggggagtg ctacattcag tttttttcca atgctgctgt cacctttggt acggctattg   1200

cagccttcta tttgccagtg atcatcatga ctgtgctata ttggcacata tcccgagcca   1260

gcaagagcag gataaagaag gacaagaagg agcctgttgc caaccaagac cccgtttctc   1320

caagtctggt acaaggaagg atagtgaagc caaacaataa caacatgccc agcagtgacg   1380

atggcctgga gcacaacaaa atccagaatg gcaaagcccc cagggatcct gtgactgaaa   1440

actgtgttca gggagaggag aaggagagct ccaatgactc cacctcagtc agtgctgttg   1500

cctctaatat gagagatgat gaaataaccc aggatgaaaa cacagtttcc acttccctgg   1560

gccattccaa agatgagaac tctaagcaaa catgcatcag aattggcacc aagaccccaa   1620

aaagtgactc atgtacccca actaatacca ccgtggaggt agtggggtct tcaggtcaga   1680

atggagatga aaagcagaat attgtagccc gcaagattgt gaagatgact aagcagcctg   1740

caaaaaagaa gcctcctcct tcccgggaaa agaaagtcac caggacaatc ttggctattc   1800

tgttggcttt catcatcact tgggccccat acaatgtcat ggtgctcatt aacacctttt   1860

gtgcaccttg catccccaac actgtgtgga caattggtta ctggctttgt tacatcaaca   1920

gcactatcaa ccctgcctgc tatgcacttt gcaatgccac cttcaagaag acctttaaac   1980

accttctcat gtgtcattat aagaacatag gcgctacaag gtaaaatatc tttgaaaaag   2040

atagaaggtg ggcaagggga gcttgagaag aataaaaggg ataaacgagc tcctagtttt   2100

aaaatctctg ccattgcact ttatagtctg attacaaaac gtgcaattca ggagcccagc   2160

agtgacacac ttatcacgcc taggctccag tttgcaaaaa ttgcacctta taaactgtca   2220

gtattaggag caatgagaca atgaaagaaa catgttggga tcgtggattt aagaaactat   2280

acactgtttc tcataatctc ttgaagaagg gcttctgatt ctacaatttt atcagtctct   2340

gcacaagagg aataaccttg ttcctttttt gttacttttg ttgttgttgt tctcatgtgt   2400

ccttaagaga aggaaatgcc acagttacaa ggtaaacatg gagacttaaa cataaagaaa   2460

taggcactat acaatgggga cataaaaaaa gaaaatcaaa gaaggatgca gaaattgtct   2520

ccggagtgtt aagcatattt tattcttttg ttacggtcct atttagagga ttggaatgta   2580

ataaatgctt attttttgcc tttctttttc ccaccatgaa gagaaagcaa acaaacagaa   2640

accccaacta ggtcacacca tttttcttct tgttatgcca ctattttgta catccctgtt   2700

ctatattgtt tatagggaaa acctacagga ctttcactaa agctagccag agacagccat   2760

gaaaatggac gtttcacccc tc                                            2782


<210>  456
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  456

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  457
<211>  795
<212>  DNA
<213>  Homosapiens

<400>  457
atggcctatg agtcattgat tggtatttct acagaaaact tcagttttta tctgtttaca     60

aatcaactaa agcatgaggt tacaactact tttgactttc gcaagttttt tgggtcaaaa    120

atagtttttc agacatcaga tgataagtac tgtgtacata ccctggggcc acctttatgc    180

catctaaacc ccagcaaaga aggatggaaa gagtcaaaag aggaagagag agtggcaatg    240

gtaccaagac tagctttcat tcttttcgtt cttgccaggg attacaatgt cacaagcctg    300

gggcaggatc ttaattggaa gtatgaagct aaggattata gaaaaacagg tgaactgaag    360

aatattggag agtgtggccg atcttataag ttcctctcaa gaaatcaaga ctggaataca    420

aggtattcac accctaacag gcctgctaag tactcaggaa tagatgagat gtgcaaggcc    480

caggagtctg gactctcacc gagcaagcag ctgaacaggc tttcaacatt aactgccctc    540

aaggtatctc aacctgtgaa actagccctg ttcctccagg agtccaagaa gagagatacg    600

agtgggacgc taacagtact ccaagaaaga ttgaggggct tctacagcaa aaaatgtatt    660

tgtctggatt ctcagaatgt agcaaaggag attgaaggca gtagagcagc cctgcatcta    720

acaagagccc taagatgtag agtggaaatc gttggtctta agacagttcc tcagattacc    780

ccacaaccaa tatga                                                     795


<210>  458
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  458

Met Ala Tyr Glu Ser Leu Ile Gly Ile Ser Thr Glu Asn Phe Ser Phe 
1               5                   10                  15      


Tyr Leu Phe Thr Asn Gln Leu Lys His Glu Val Thr Thr Thr Phe Asp 
            20                  25                  30          


Phe Arg Lys Phe Phe Gly Ser Lys Ile Val Phe Gln Thr Ser Asp Asp 
        35                  40                  45              


Lys Tyr Cys Val His Thr Leu Gly Pro Pro Leu Cys His Leu Asn Pro 
    50                  55                  60                  


Ser Lys Glu Gly Trp Lys Glu Ser Lys Glu Glu Glu Arg Val Ala Met 
65                  70                  75                  80  


Val Pro Arg Leu Ala Phe Ile Leu Phe Val Leu Ala Arg Asp Tyr Asn 
                85                  90                  95      


Val Thr Ser Leu Gly Gln Asp Leu Asn Trp Lys Tyr Glu Ala Lys Asp 
            100                 105                 110         


Tyr Arg Lys Thr Gly Glu Leu Lys Asn Ile Gly Glu Cys Gly Arg Ser 
        115                 120                 125             


Tyr Lys Phe Leu Ser Arg Asn Gln Asp Trp Asn Thr Arg Tyr Ser His 
    130                 135                 140                 


Pro Asn Arg Pro Ala Lys Tyr Ser Gly Ile Asp Glu Met Cys Lys Ala 
145                 150                 155                 160 


Gln Glu Ser Gly Leu Ser Pro Ser Lys Gln Leu Asn Arg Leu Ser Thr 
                165                 170                 175     


Leu Thr Ala Leu Lys Val Ser Gln Pro Val Lys Leu Ala Leu Phe Leu 
            180                 185                 190         


Gln Glu Ser Lys Lys Arg Asp Thr Ser Gly Thr Leu Thr Val Leu Gln 
        195                 200                 205             


Glu Arg Leu Arg Gly Phe Tyr Ser Lys Lys Cys Ile Cys Leu Asp Ser 
    210                 215                 220                 


Gln Asn Val Ala Lys Glu Ile Glu Gly Ser Arg Ala Ala Leu His Leu 
225                 230                 235                 240 


Thr Arg Ala Leu Arg Cys Arg Val Glu Ile Val Gly Leu Lys Thr Val 
                245                 250                 255     


Pro Gln Ile Thr Pro Gln Pro Ile 
            260                 


<210>  459
<211>  1558
<212>  DNA
<213>  Homosapiens

<400>  459
gagtgcaaag cgctctccct ccctcgccca gccttcgtcc tcctggcccg ctcctctcat     60

ccctcccatt ctccatttcc cttccgttcc ctccctgtca gggcgtaatt gagtcaaagg    120

caggatcagg ttccccgcct tccagtccaa aaatcccgcc aagagagccc cagagcagag    180

gaaaatccaa agtggagaga ggggaagaaa gagaccagtg agtcatccgt ccagaaggcg    240

gggagagcag cagcggccca agcaggagct gcagcgagcc gggtacctgg actcagcggt    300

agcaacctcg ccccttgcaa caaaggcaga ctgagcgcca gagaggacgt ttccaactca    360

aaaatgcagg ctcaacagta ccagcagcag cgtcgaaaat ttgcagctgc cttcttggca    420

ttcattttca tactggcagc tgtggatact gctgaagcag ggaagaaaga gaaaccagaa    480

aaaaaagtga agaagtctga ctgtggagaa tggcagtgga gtgtgtgtgt gcccaccagt    540

ggagactgtg ggctgggcac acgggagggc actcggactg gagctgagtg caagcaaacc    600

atgaagaccc agagatgtaa gatcccctgc aactggaaga agcaatttgg cgcggagtgc    660

aaataccagt tccaggcctg gggagaatgt gacctgaaca cagccctgaa gaccagaact    720

ggaagtctga agcgagccct gcacaatgcc gaatgccaga agactgtcac catctccaag    780

ccctgtggca aactgaccaa gcccaaacct caagcagaat ctaagaagaa gaaaaaggaa    840

ggcaagaaac aggagaagat gctggattaa aagatgtcac ctgtggaaca taaaaaggac    900

atcagcaaac aggatcagtt aactattgca tttatatgta ccgtaggctt tgtattcaaa    960

aattatctat agctaagtac acaataagca aaaacaaaaa gaaaagaaaa tttttgtagt   1020

agcgtttttt aaatgtatac tatagtacca gtaggggctt ataataaagg actgtaatct   1080

tatttaggaa gttgacttat agtacatgat aaatgataga caattgaggt aagttttttg   1140

aaattatgtg acattttaca ttaaattttt tttacatttt ttgggcagca atttaaatgt   1200

tatgactatg taaactactt ctcttgttag gtaatttttt tcacctagat ttttttccca   1260

attgagaaaa atatatacta aacaaaatag caataaaaca taatcactct atttgaagaa   1320

aatatcttgt tttctgccaa tagatttttt aaaatgtagt cagcaaaatg ggggtgggga   1380

agcagagcat gtcctagttc aatgttgact tttttttttt ttaaagaaaa gcattaagac   1440

ataaaattct ttcactttgg cagaagcatt tgttttcttg atgaaattat ttttccatct   1500

gaggaaaaaa atactaggaa aataaatcaa ggtgatgctg aaaaaaaaaa aaaaaaaa     1558


<210>  460
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  460

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 
        35                  40                  45              


Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 
    50                  55                  60                  


Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 
65                  70                  75                  80  


Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 
                85                  90                  95      


Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 
            100                 105                 110         


Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 
        115                 120                 125             


Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 
    130                 135                 140                 


Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 
145                 150                 155                 160 


Lys Lys Gln Glu Lys Met Leu Asp 
                165             


<210>  461
<211>  4073
<212>  DNA
<213>  Homosapiens

<400>  461
gcgcttgcgg aggattgcgt tgacgagact cttatttatt gtcaccaacc tgtggtggaa     60

tttgcagttg cacattggat ctgattcgcc ccgccccgaa tgacgcctgc ccggaggcag    120

tgaaagtaca gccgcgccgc cccaagtcag cctggacaca taaatcagca cgcggccgga    180

gaaccccgca atctctgcgc ccacaaaata caccgacgat gcccgatcta ctttaagggc    240

tgaaacccac gggcctgaga gactataaga gcgttcccta ccgccatgga acaacgggga    300

cagaacgccc cggccgcttc gggggcccgg aaaaggcacg gcccaggacc cagggaggcg    360

cggggagcca ggcctgggct ccgggtcccc aagacccttg tgctcgttgt cgccgcggtc    420

ctgctgttgg tctcagctga gtctgctctg atcacccaac aagacctagc tccccagcag    480

agagcggccc cacaacaaaa gaggtccagc ccctcagagg gattgtgtcc acctggacac    540

catatctcag aagacggtag agattgcatc tcctgcaaat atggacagga ctatagcact    600

cactggaatg acctcctttt ctgcttgcgc tgcaccaggt gtgattcagg tgaagtggag    660

ctaagtccct gcaccacgac cagaaacaca gtgtgtcagt gcgaagaagg caccttccgg    720

gaagaagatt ctcctgagat gtgccggaag tgccgcacag ggtgtcccag agggatggtc    780

aaggtcggtg attgtacacc ctggagtgac atcgaatgtg tccacaaaga atcaggcatc    840

atcataggag tcacagttgc agccgtagtc ttgattgtgg ctgtgtttgt ttgcaagtct    900

ttactgtgga agaaagtcct tccttacctg aaaggcatct gctcaggtgg tggtggggac    960

cctgagcgtg tggacagaag ctcacaacga cctggggctg aggacaatgt cctcaatgag   1020

atcgtgagta tcttgcagcc cacccaggtc cctgagcagg aaatggaagt ccaggagcca   1080

gcagagccaa caggtgtcaa catgttgtcc cccggggagt cagagcatct gctggaaccg   1140

gcagaagctg aaaggtctca gaggaggagg ctgctggttc cagcaaatga aggtgatccc   1200

actgagactc tgagacagtg cttcgatgac tttgcagact tggtgccctt tgactcctgg   1260

gagccgctca tgaggaagtt gggcctcatg gacaatgaga taaaggtggc taaagctgag   1320

gcagcgggcc acagggacac cttgtacacg atgctgataa agtgggtcaa caaaaccggg   1380

cgagatgcct ctgtccacac cctgctggat gccttggaga cgctgggaga gagacttgcc   1440

aagcagaaga ttgaggacca cttgttgagc tctggaaagt tcatgtatct agaaggtaat   1500

gcagactctg ccatgtccta agtgtgattc tcttcaggaa gtcagacctt ccctggttta   1560

ccttttttct ggaaaaagcc caactggact ccagtcagta ggaaagtgcc acaattgtca   1620

catgaccggt actggaagaa actctcccat ccaacatcac ccagtggatg gaacatcctg   1680

taacttttca ctgcacttgg cattattttt ataagctgaa tgtgataata aggacactat   1740

ggaaatgtct ggatcattcc gtttgtgcgt actttgagat ttggtttggg atgtcattgt   1800

tttcacagca cttttttatc ctaatgtaaa tgctttattt atttatttgg gctacattgt   1860

aagatccatc tacacagtcg ttgtccgact tcacttgata ctatatgata tgaacctttt   1920

ttgggtgggg ggtgcggggc agttcactct gtctcccagg ctggagtgca atggtgcaat   1980

cttggctcac tatagccttg acctctcagg ctcaagcgat tctcccacct cagccatcca   2040

aatagctggg accacaggtg tgcaccacca cgcccggcta attttttgta ttttgtctag   2100

atataggggc tctctatgtt gctcagggtg gtctcgaatt cctggactca agcagtctgc   2160

ccacctcaga ctcccaaagc ggtggaatta gaggcgtgag cccccatgct tggccttacc   2220

tttctacttt tataattctg tatgttatta ttttatgaac atgaagaaac tttagtaaat   2280

gtacttgttt acatagttat gtgaatagat tagataaaca taaaaggagg agacatacaa   2340

tgggggaaga agaagaagtc ccctgtaaga tgtcactgtc tgggttccag ccctccctca   2400

gatgtacttt ggcttcaatg attggcaact tctacagggg ccagtctttt gaactggaca   2460

accttacaag tatatgagta ttatttatag gtagttgttt acatatgagt cgggaccaaa   2520

gagaactgga tccacgtgaa gtcctgtgtg tggctggtcc ctacctgggc agtctcattt   2580

gcacccatag cccccatcta tggacaggct gggacagagg cagatgggtt agatcacaca   2640

taacaatagg gtctatgtca tatcccaagt gaacttgagc cctgtttggg ctcaggagat   2700

agaagacaaa atctgtctcc cacgtctgcc atggcatcaa gggggaagag tagatggtgc   2760

ttgagaatgg tgtgaaatgg ttgccatctc aggagtagat ggcccggctc acttctggtt   2820

atctgtcacc ctgagcccat gagctgcctt ttagggtaca gattgcctac ttgaggacct   2880

tggccgctct gtaagcatct gactcatctc agaaatgtca attcttaaac actgtggcaa   2940

caggacctag aatggctgac gcattaaggt tttcttcttg tgtcctgttc tattattgtt   3000

ttaagacctc agtaaccatt tcagcctctt tccagcaaac ccttctccat agtatttcag   3060

tcatggaagg atcatttatg caggtagtca ttccaggagt ttttggtctt ttctgtctca   3120

aggcattgtg tgttttgttc cgggactggt ttgggtggga caaagttaga attgcctgaa   3180

gatcacacat tcagactgtt gtgtctgtgg agttttagga gtggggggtg acctttctgg   3240

tctttgcact tccatcctct cccacttcca tctggcatcc cacgcgttgt cccctgcact   3300

tctggaaggc acagggtgct gctgcctcct ggtctttgcc tttgctgggc cttctgtgca   3360

ggacgctcag cctcagggct cagaaggtgc cagtccggtc ccaggtccct tgtcccttcc   3420

acagaggcct tcctagaaga tgcatctaga gtgtcagcct tatcagtgtt taagatttgt   3480

cttttatttt taattttttt gagacagaat ctcactctct cgcccaggct ggagtgcaac   3540

ggtacgatct tggctcagtg caacctccgc ctcctgggtt caagcgattc tcgtgcctca   3600

gcctccggag tagctgggat tgcaggcacc cgccaccacg cctggctaat ttttgtattt   3660

ttagtagaga cggggtttca ccatgttggt caggctggtc tcgaactcct gacctcaggt   3720

gatccacctt ggcctccgaa agtgctggga ttacaggcgt gagccaccag ccaggccaag   3780

ctattctttt aaagtaagct tcctgacgac atgaaataat tgggggtttt gttgtttagt   3840

tacattaggc tttgctatat ccccaggcca aatagcatgt gacacaggac agccatagta   3900

tagtgtgtca ctcgtggttg gtgtcctttc atgcttctgc cctgtcaaag gtccctattt   3960

gaaatgtgtt ataatacaaa caaggaagca cattgtgtac aaaatactta tgtatttatg   4020

aatccatgac caaattaaat atgaaacctt atataaaaaa aaaaaaaaaa aaa          4073


<210>  462
<211>  411
<212>  PRT
<213>  Homosapiens

<400>  462

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Leu 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly 
    210                 215                 220                 


Asp Pro Glu Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp 
225                 230                 235                 240 


Asn Val Leu Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro 
                245                 250                 255     


Glu Gln Glu Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn 
            260                 265                 270         


Met Leu Ser Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala 
        275                 280                 285             


Glu Arg Ser Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp 
    290                 295                 300                 


Pro Thr Glu Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val 
305                 310                 315                 320 


Pro Phe Asp Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp 
                325                 330                 335     


Asn Glu Ile Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr 
            340                 345                 350         


Leu Tyr Thr Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala 
        355                 360                 365             


Ser Val His Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu 
    370                 375                 380                 


Ala Lys Gln Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met 
385                 390                 395                 400 


Tyr Leu Glu Gly Asn Ala Asp Ser Ala Met Ser 
                405                 410     


<210>  463
<211>  4160
<212>  DNA
<213>  Homosapiens

<400>  463
gcgcttgcgg aggattgcgt tgacgagact cttatttatt gtcaccaacc tgtggtggaa     60

tttgcagttg cacattggat ctgattcgcc ccgccccgaa tgacgcctgc ccggaggcag    120

tgaaagtaca gccgcgccgc cccaagtcag cctggacaca taaatcagca cgcggccgga    180

gaaccccgca atctctgcgc ccacaaaata caccgacgat gcccgatcta ctttaagggc    240

tgaaacccac gggcctgaga gactataaga gcgttcccta ccgccatgga acaacgggga    300

cagaacgccc cggccgcttc gggggcccgg aaaaggcacg gcccaggacc cagggaggcg    360

cggggagcca ggcctgggct ccgggtcccc aagacccttg tgctcgttgt cgccgcggtc    420

ctgctgttgg tctcagctga gtctgctctg atcacccaac aagacctagc tccccagcag    480

agagcggccc cacaacaaaa gaggtccagc ccctcagagg gattgtgtcc acctggacac    540

catatctcag aagacggtag agattgcatc tcctgcaaat atggacagga ctatagcact    600

cactggaatg acctcctttt ctgcttgcgc tgcaccaggt gtgattcagg tgaagtggag    660

ctaagtccct gcaccacgac cagaaacaca gtgtgtcagt gcgaagaagg caccttccgg    720

gaagaagatt ctcctgagat gtgccggaag tgccgcacag ggtgtcccag agggatggtc    780

aaggtcggtg attgtacacc ctggagtgac atcgaatgtg tccacaaaga atcaggtaca    840

aagcacagtg gggaagcccc agctgtggag gagacggtga cctccagccc agggactcct    900

gcctctccct gttctctctc aggcatcatc ataggagtca cagttgcagc cgtagtcttg    960

attgtggctg tgtttgtttg caagtcttta ctgtggaaga aagtccttcc ttacctgaaa   1020

ggcatctgct caggtggtgg tggggaccct gagcgtgtgg acagaagctc acaacgacct   1080

ggggctgagg acaatgtcct caatgagatc gtgagtatct tgcagcccac ccaggtccct   1140

gagcaggaaa tggaagtcca ggagccagca gagccaacag gtgtcaacat gttgtccccc   1200

ggggagtcag agcatctgct ggaaccggca gaagctgaaa ggtctcagag gaggaggctg   1260

ctggttccag caaatgaagg tgatcccact gagactctga gacagtgctt cgatgacttt   1320

gcagacttgg tgccctttga ctcctgggag ccgctcatga ggaagttggg cctcatggac   1380

aatgagataa aggtggctaa agctgaggca gcgggccaca gggacacctt gtacacgatg   1440

ctgataaagt gggtcaacaa aaccgggcga gatgcctctg tccacaccct gctggatgcc   1500

ttggagacgc tgggagagag acttgccaag cagaagattg aggaccactt gttgagctct   1560

ggaaagttca tgtatctaga aggtaatgca gactctgcca tgtcctaagt gtgattctct   1620

tcaggaagtc agaccttccc tggtttacct tttttctgga aaaagcccaa ctggactcca   1680

gtcagtagga aagtgccaca attgtcacat gaccggtact ggaagaaact ctcccatcca   1740

acatcaccca gtggatggaa catcctgtaa cttttcactg cacttggcat tatttttata   1800

agctgaatgt gataataagg acactatgga aatgtctgga tcattccgtt tgtgcgtact   1860

ttgagatttg gtttgggatg tcattgtttt cacagcactt ttttatccta atgtaaatgc   1920

tttatttatt tatttgggct acattgtaag atccatctac acagtcgttg tccgacttca   1980

cttgatacta tatgatatga accttttttg ggtggggggt gcggggcagt tcactctgtc   2040

tcccaggctg gagtgcaatg gtgcaatctt ggctcactat agccttgacc tctcaggctc   2100

aagcgattct cccacctcag ccatccaaat agctgggacc acaggtgtgc accaccacgc   2160

ccggctaatt ttttgtattt tgtctagata taggggctct ctatgttgct cagggtggtc   2220

tcgaattcct ggactcaagc agtctgccca cctcagactc ccaaagcggt ggaattagag   2280

gcgtgagccc ccatgcttgg ccttaccttt ctacttttat aattctgtat gttattattt   2340

tatgaacatg aagaaacttt agtaaatgta cttgtttaca tagttatgtg aatagattag   2400

ataaacataa aaggaggaga catacaatgg gggaagaaga agaagtcccc tgtaagatgt   2460

cactgtctgg gttccagccc tccctcagat gtactttggc ttcaatgatt ggcaacttct   2520

acaggggcca gtcttttgaa ctggacaacc ttacaagtat atgagtatta tttataggta   2580

gttgtttaca tatgagtcgg gaccaaagag aactggatcc acgtgaagtc ctgtgtgtgg   2640

ctggtcccta cctgggcagt ctcatttgca cccatagccc ccatctatgg acaggctggg   2700

acagaggcag atgggttaga tcacacataa caatagggtc tatgtcatat cccaagtgaa   2760

cttgagccct gtttgggctc aggagataga agacaaaatc tgtctcccac gtctgccatg   2820

gcatcaaggg ggaagagtag atggtgcttg agaatggtgt gaaatggttg ccatctcagg   2880

agtagatggc ccggctcact tctggttatc tgtcaccctg agcccatgag ctgcctttta   2940

gggtacagat tgcctacttg aggaccttgg ccgctctgta agcatctgac tcatctcaga   3000

aatgtcaatt cttaaacact gtggcaacag gacctagaat ggctgacgca ttaaggtttt   3060

cttcttgtgt cctgttctat tattgtttta agacctcagt aaccatttca gcctctttcc   3120

agcaaaccct tctccatagt atttcagtca tggaaggatc atttatgcag gtagtcattc   3180

caggagtttt tggtcttttc tgtctcaagg cattgtgtgt tttgttccgg gactggtttg   3240

ggtgggacaa agttagaatt gcctgaagat cacacattca gactgttgtg tctgtggagt   3300

tttaggagtg gggggtgacc tttctggtct ttgcacttcc atcctctccc acttccatct   3360

ggcatcccac gcgttgtccc ctgcacttct ggaaggcaca gggtgctgct gcctcctggt   3420

ctttgccttt gctgggcctt ctgtgcagga cgctcagcct cagggctcag aaggtgccag   3480

tccggtccca ggtcccttgt cccttccaca gaggccttcc tagaagatgc atctagagtg   3540

tcagccttat cagtgtttaa gatttgtctt ttatttttaa tttttttgag acagaatctc   3600

actctctcgc ccaggctgga gtgcaacggt acgatcttgg ctcagtgcaa cctccgcctc   3660

ctgggttcaa gcgattctcg tgcctcagcc tccggagtag ctgggattgc aggcacccgc   3720

caccacgcct ggctaatttt tgtattttta gtagagacgg ggtttcacca tgttggtcag   3780

gctggtctcg aactcctgac ctcaggtgat ccaccttggc ctccgaaagt gctgggatta   3840

caggcgtgag ccaccagcca ggccaagcta ttcttttaaa gtaagcttcc tgacgacatg   3900

aaataattgg gggttttgtt gtttagttac attaggcttt gctatatccc caggccaaat   3960

agcatgtgac acaggacagc catagtatag tgtgtcactc gtggttggtg tcctttcatg   4020

cttctgccct gtcaaaggtc cctatttgaa atgtgttata atacaaacaa ggaagcacat   4080

tgtgtacaaa atacttatgt atttatgaat ccatgaccaa attaaatatg aaaccttata   4140

taaaaaaaaa aaaaaaaaaa                                               4160


<210>  464
<211>  440
<212>  PRT
<213>  Homosapiens

<400>  464

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Leu 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Ala Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  465
<211>  1404
<212>  DNA
<213>  Homosapiens

<400>  465
ggcagtgcag ctgtgggaac ctctccacgc gcacgaactc agccaacgat ttctgataga     60

tttttgggag tttgaccaga gatgcaaggg gtgaaggagc gcttcctacc gttagggaac    120

tctggggaca gagcgccccg gccgcctgat ggccgaggca gggtgcgacc caggacccag    180

gacggcgtcg ggaaccatac catggcccgg atccccaaga ccctaaagtt cgtcgtcgtc    240

atcgtcgcgg tcctgctgcc agtcctagct tactctgcca ccactgcccg gcaggaggaa    300

gttccccagc agacagtggc cccacagcaa cagaggcaca gcttcaaggg ggaggagtgt    360

ccagcaggat ctcatagatc agaacatact ggagcctgta acccgtgcac agagggtgtg    420

gattacacca acgcttccaa caatgaacct tcttgcttcc catgtacagt ttgtaaatca    480

gatcaaaaac ataaaagttc ctgcaccatg accagagaca cagtgtgtca gtgtaaagaa    540

ggcaccttcc ggaatgaaaa ctccccagag atgtgccgga agtgtagcag gtgccctagt    600

ggggaagtcc aagtcagtaa ttgtacgtcc tgggatgata tccagtgtgt tgaagaattt    660

ggtgccaatg ccactgtgga aaccccagct gctgaagaga caatgaacac cagcccgggg    720

actcctgccc cagctgctga agagacaatg aacaccagcc cagggactcc tgccccagct    780

gctgaagaga caatgaccac cagcccgggg actcctgccc cagctgctga agagacaatg    840

accaccagcc cggggactcc tgccccagct gctgaagaga caatgaccac cagcccgggg    900

actcctgcct cttctcatta cctctcatgc accatcgtag ggatcatagt tctaattgtg    960

cttctgattg tgtttgtttg aaagacttca ctgtggaaga aattccttcc ttacctgaaa   1020

ggttcaggta ggcgctggct gagggcgggg ggcgctggac actctctgcc ctgcctccct   1080

ctgctgtgtt cccacagaca gaaacgcctg cccctgcccc aagtcctggt gtctccagcc   1140

tggctctatc ttcctccttg tgatcgtccc atccccacat cccgtgcacc ccccaggacc   1200

ctggtctcat cagtccctct cctggagctg ggggtccaca catctcccag ccaagtccaa   1260

gagggcaggg ccagttcctc ccatcttcag gcccagccag gcagggggca gtcggctcct   1320

caactgggtg acaagggtga ggatgagaag tggtcacggg atttattcag ccttggtcag   1380

agcagaaaaa aaaaaaaaaa aaaa                                          1404


<210>  466
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  466

Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210>  467
<211>  3561
<212>  DNA
<213>  Homosapiens

<400>  467
agtgtagctg cgagaacctt tgcacgcgca caaactacgg ggacgatttc tgattgattt     60

ttggcgcttt cgatccaccc tcctcccttc tcatgggact ttggggacaa agcgtcccga    120

ccgcctcgag cgctcgagca gggcgctatc caggagccag gacagcgtcg ggaaccagac    180

catggctcct ggaccccaag atccttaagt tcgtcgtctt catcgtcgcg gttctgctgc    240

cggtccgggt tgactctgcc accatccccc ggcaggacga agttccccag cagacagtgg    300

ccccacagca acagaggcgc agcctcaagg aggaggagtg tccagcagga tctcatagat    360

cagaatatac tggagcctgt aacccgtgca cagagggtgt ggattacacc attgcttcca    420

acaatttgcc ttcttgcctg ctatgtacag tttgtaaatc aggtcaaaca aataaaagtt    480

cctgtaccac gaccagagac accgtgtgtc agtgtgaaaa aggaagcttc caggataaaa    540

actcccctga gatgtgccgg acgtgtagaa cagggtgtcc cagagggatg gtcaaggtca    600

gtaattgtac gccccggagt gacatcaagt gcaaaaatga atcagctgcc agttccactg    660

ggaaaacccc agcagcggag gagacagtga ccaccatcct ggggatgctt gcctctccct    720

atcactacct tatcatcata gtggttttag tcatcatttt agctgtggtt gtggttggct    780

tttcatgtcg gaagaaattc atttcttacc tcaaaggcat ctgctcaggt ggtggaggag    840

gtcccgaacg tgtgcacaga gtccttttcc ggcggcgttc atgtccttca cgagttcctg    900

gggcggagga caatgcccgc aacgagaccc tgagtaacag atacttgcag cccacccagg    960

tctctgagca ggaaatccaa ggtcaggagc tggcagagct aacaggtgtg actgtagagt   1020

tgccagagga gccacagcgt ctgctggaac aggcagaagc tgaagggtgt cagaggagga   1080

ggctgctggt tccagtgaat gacgctgact ccgctgacat cagcaccttg ctggatgcct   1140

cggcaacact ggaagaagga catgcaaagg aaacaattca ggaccaactg gtgggctccg   1200

aaaagctctt ttatgaagaa gatgaggcag gctctgctac gtcctgcctg tgaaagaatc   1260

tcttcaggaa accagagctt ccctcattta ccttttctcc tacaaaggga agcagcctgg   1320

aagaaacagt ccagtacttg acccatgccc caacaaactc tactatccaa tatggggcag   1380

cttaccaatg gtcctagaac tttgttaacg cacttggagt aatttttatg aaatactgcg   1440

tgtgataagc aaacgggaga aatttatatc agattcttgg ctgcatagtt atacgattgt   1500

gtattaaggg tcgttttagg ccacatgcgg tggctcatgc ctgtaatccc agcactttga   1560

taggctgagg caggtggatt gcttgagctc gggagtttga gaccagcctc atcaacacag   1620

tgaaactcca tctcaattta aaaagaaaaa aagtggtttt aggatgtcat tctttgcagt   1680

tcttcatcat gagacaagtc tttttttctg cttcttatat tgcaagctcc atctctactg   1740

gtgtgtgcat ttaatgacat ctaactacag atgccgcaca gccacaatgc tttgccttat   1800

agttttttaa ctttagaacg ggattatctt gttattacct gtattttcag tttcggatat   1860

ttttgactta atgatgagat tatcaagacg tagccctatg ctaagtcatg agcatatgga   1920

cttacgaggg ttcgacttag agttttgagc tttaagatag gattattggg gcttaccccc   1980

accttaatta gagaaacatt tatattgctt actactgtag gctgtacatc tcttttccga   2040

tttttgtata atgatgtaaa catggaaaaa ctttaggaaa tgcacttatt aggctgttta   2100

catgggttgc ctggatacaa atcagcagtc aaaaatgact aaaaatataa ctagtgacgg   2160

agggagaaat cctccctctg tgggaggcac ttactgcatt ccagttctcc ctcctgcgcc   2220

ctgagactgg accagggttt gatggctggc agcttctcaa ggggcagctt gtcttacttg   2280

ttaattttag aggtatatag ccatatttat ttataaataa atatttattt atttatttat   2340

aagtagatgt ttacatatgc ccaggatttt gaagagcctg gtatctttgg gaagccatgt   2400

gtctggtttg tcgtgctggg acagtcatgg gactgcatct tccgacttgt ccacagcaga   2460

tgaggacagt gagaattaag ttagatccga gactgcgaag agcttctctt tcaagcgcca   2520

ttacagttga acgttagtga atcttgagcc tcatttgggc tcagggcaga gcaggtgttt   2580

atctgccccg gcatctgcca tggcatcaag agggaagagt ggacggtgct tgggaatggt   2640

gtgaaatggt tgccgactca ggcatggatg ggcccctctc gcttctggtg gtctgtgaac   2700

tgagtccctg ggatgccttt tagggcagag attcctgagc tgcgttttag ggtacagatt   2760

ccctgtttga ggagcttggc ccctctgtaa gcatctgact catctcagag atatcaattc   2820

ttaaacactg tgacaacagg atctaaaatg gctgacacat ttgtccttgt gtcacgttcc   2880

attattttat ttaaaaacct cagtaatcgt tttagcttct ttccagcaaa ctcttctcca   2940

cagtagccca gtcgtggtag gataaattac ggatatagtc attctagggg tttcagtctt   3000

ttccatctca aggcattgtg tgttttgttc cgggactggt ttggctggga caaagttaga   3060

actgcctgaa gttcgcacat tcagattgtt gtgtccatgg agttttagga ggggatggcc   3120

tttccggtct tcgcacttcc atcctctccc acttccatct ggcgtcccac accttgtccc   3180

ctgcacttct ggatgacaca gggtgctgct gcctcctagt ctttgccttt gctgggcctt   3240

ctgtgcagga gacttggtct caaagctcag agagagccag tccggtccca gctcctttgt   3300

cccttcctca gaggccttcc ttgaagatgc atctagacta ccagccttat cagtgtttaa   3360

gcttattcct ttaacataag cttcctgaca acatgaaatt gttggggttt tttggcgttg   3420

gttgatttgt ttaggttttg ctttataccc gggccaaata gcacataaca cctggttata   3480

tatgaaatac tcatatgttt atgaccaaaa taaatatgaa acctcatatt aaaaaaaaaa   3540

aaaaaaaaaa aaaaaaaaaa a                                             3561


<210>  468
<211>  386
<212>  PRT
<213>  Homosapiens

<400>  468

Met Gly Leu Trp Gly Gln Ser Val Pro Thr Ala Ser Ser Ala Arg Ala 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Ala Arg Thr Ala Ser Gly Thr Arg Pro Trp Leu 
            20                  25                  30          


Leu Asp Pro Lys Ile Leu Lys Phe Val Val Phe Ile Val Ala Val Leu 
        35                  40                  45              


Leu Pro Val Arg Val Asp Ser Ala Thr Ile Pro Arg Gln Asp Glu Val 
    50                  55                  60                  


Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg Arg Ser Leu Lys Glu 
65                  70                  75                  80  


Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu Tyr Thr Gly Ala Cys 
                85                  90                  95      


Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Ile Ala Ser Asn Asn Leu 
            100                 105                 110         


Pro Ser Cys Leu Leu Cys Thr Val Cys Lys Ser Gly Gln Thr Asn Lys 
        115                 120                 125             


Ser Ser Cys Thr Thr Thr Arg Asp Thr Val Cys Gln Cys Glu Lys Gly 
    130                 135                 140                 


Ser Phe Gln Asp Lys Asn Ser Pro Glu Met Cys Arg Thr Cys Arg Thr 
145                 150                 155                 160 


Gly Cys Pro Arg Gly Met Val Lys Val Ser Asn Cys Thr Pro Arg Ser 
                165                 170                 175     


Asp Ile Lys Cys Lys Asn Glu Ser Ala Ala Ser Ser Thr Gly Lys Thr 
            180                 185                 190         


Pro Ala Ala Glu Glu Thr Val Thr Thr Ile Leu Gly Met Leu Ala Ser 
        195                 200                 205             


Pro Tyr His Tyr Leu Ile Ile Ile Val Val Leu Val Ile Ile Leu Ala 
    210                 215                 220                 


Val Val Val Val Gly Phe Ser Cys Arg Lys Lys Phe Ile Ser Tyr Leu 
225                 230                 235                 240 


Lys Gly Ile Cys Ser Gly Gly Gly Gly Gly Pro Glu Arg Val His Arg 
                245                 250                 255     


Val Leu Phe Arg Arg Arg Ser Cys Pro Ser Arg Val Pro Gly Ala Glu 
            260                 265                 270         


Asp Asn Ala Arg Asn Glu Thr Leu Ser Asn Arg Tyr Leu Gln Pro Thr 
        275                 280                 285             


Gln Val Ser Glu Gln Glu Ile Gln Gly Gln Glu Leu Ala Glu Leu Thr 
    290                 295                 300                 


Gly Val Thr Val Glu Leu Pro Glu Glu Pro Gln Arg Leu Leu Glu Gln 
305                 310                 315                 320 


Ala Glu Ala Glu Gly Cys Gln Arg Arg Arg Leu Leu Val Pro Val Asn 
                325                 330                 335     


Asp Ala Asp Ser Ala Asp Ile Ser Thr Leu Leu Asp Ala Ser Ala Thr 
            340                 345                 350         


Leu Glu Glu Gly His Ala Lys Glu Thr Ile Gln Asp Gln Leu Val Gly 
        355                 360                 365             


Ser Glu Lys Leu Phe Tyr Glu Glu Asp Glu Ala Gly Ser Ala Thr Ser 
    370                 375                 380                 


Cys Leu 
385     


<210>  469
<211>  3370
<212>  DNA
<213>  Homosapiens

<400>  469
aagtaagcaa acattttcct ctaattcaga ttctttaaac aaaagttgca aatgaatgta     60

gccttcatct attgtaaaat taaagatgga gatggtcaag gggttaccgc cagtctgttt    120

cttgcgctga taatttttct agacattaaa tctcaccatt tgttcccaac aaagaaagaa    180

agacaggacc accagactct acagggaagc caagaggaag aagggaagga gcccagaaat    240

ggagagaagc tggactctag ggatggatct ggggatgctc cacaaagtgc agctgtggag    300

aatgcagaag aagagttggc tagtgggaca ttcccactga ggagcatggc agggggaatg    360

tctaatattc actaagagaa ttcttgaaat gtaacattta gatgaaactc ttcaagtttc    420

cttaaaatac aaattcatga ctctctttct ttctctctct ctctttctct ctctctttgg    480

tatgttaaag taatcaagga aagggatttt gttttataac tgggttacac aggggagaga    540

ccagaatagc tgaaagctgt gagacatgaa gaaaattcaa gatttaggag acatgcagaa    600

catcagtgtc taggcaaaat ggcagactga ccaaccccca cacactgaat ccctagagat    660

attaggacag ggatattgag aaaaatttac ctttaagttg taaaggacaa ggcaactcaa    720

catattgaat gccttgttga caaccagggg ctaatatttg ggatgcatat tgggcataga    780

tgcacagaaa ataatttatc agtgacatta ataatatgac atctctttgt tgagaattta    840

ctgctgtctt aatatcacaa ctctaagggg tcaacatcca gaataaactt cttatcttac    900

atatttaaaa ttatttgcta ggctacattt ttcttagaaa aatgcatatc tgaaacagaa    960

tattgatttt tttcctgggt catacataaa gaccatcaga aattaattat tgaaaaaaca   1020

ctgctatact cattagagat atattttaat tagattaatt ttgcattaac agtccatgag   1080

aagttacaac taacttgcaa cgagacatta acatgcatca tgtttgatat aagtaaaaat   1140

ggaaatgatt agaagtatac aaatataaag tatgttgcta gtatatgcaa gcttaaaaaa   1200

cttttacctg atagaattag caagagcagc tatgttgagc ttctttcagt taaaagtcat   1260

tttcggctat gtctccctaa ggatagaaat atcactgctt ttgatctcat ttagaattct   1320

gctcactttt aggaaagtag ggctgtttgg aaatggtcag ccatatcctt actgaatttc   1380

ctagggcttg actgcaccta ctctagttaa caagtaagat atagttatat attgtattat   1440

aacttctcaa agcacttata ttttgatttt ccttctttta tgttcattat cttcatttgg   1500

actactccat gtgacaaaag cagttatttt tcttctaccc cctaaactgg accacatcga   1560

tgctcttagg tccaaatcat attctttaag aaacaagtgt tcactgaatg atttactgca   1620

ttatataata ggtactatac aagacacctg aggcccccca caccgtgaaa acagatgttt   1680

cttcctggag cttgcccaat aggagagaaa tttttaattt accctttctc agtaaaccat   1740

tatacaaaac agaagtgaaa ttatggaccc agtgaactca atctggctga cttgcaaccc   1800

ctatgtgttc ataaacccac tgaaatatat aatttgttgt ttatattaaa tatgcactga   1860

agcatgatta gataaacatt gaaagtaaat tttaatttta accatcagtg gaagtatatg   1920

gggtgattta agtcattcat attagtttat ttttatcagg tgttcctcct tgtccatagt   1980

gaaatacaat acagagatta tagcctgtgg cttgacagga catcttatag ttggtaacag   2040

gactacatta aaaggaaaaa acaataaata aggatgtcta attatacaga taaagaaagc   2100

aagttcactc actcctccag gacagcacca gagacaacgt tagaaccaag agtttcaaaa   2160

cctcgccttg tatggtttgc ctgatgccat gattaaagaa aagggggtgg ggaactaaga   2220

gaggaagcca aagagaaaga attcagtacc aaacagcaat attcagatgt tttattaaat   2280

aataggaggt gttttgacct tgctggtgaa cagaggtgat ctcaaaacat ttgacagata   2340

taattaaggc cataaggcaa taattgcaaa agtcaaggag cccttgccac ctccaaagca   2400

tcacgtgtgg atgcaggaac catattaaca acatgggtag tcaaggagaa agcagataga   2460

ataaagctgt acccagcaat ataaagggac atgcaagtgt gtgttgtgct taagagtaaa   2520

cttagggaaa aaagctcccc ataacctcga gaaacgtttc tggatctgag atatccatta   2580

gcacatttag aaggtaccta tttccattat tgtgaaggag ttgtaaatga aataaacaac   2640

tttaaataat acctcccttg gtcaaactgc attaagtatt ccctgatgga attcattcat   2700

catcattcaa acagaatggt ttgcaactca acctgcctag tgtggggtct ggaattccca   2760

ccacagtcac tgtgccttaa gcactgttgc agcagaagga cttgaagtaa cacatgaata   2820

tataatgcca atttgcatgt cagcatggat tgttgaaatt gaagttagtt aattgtcaca   2880

ttgtaacagg aaaagaatcc aagttttgga gctggttgga actgagtttt catcttcttt   2940

ctctgctact taactgtgtt atcctgaaca agatactcaa cctccatgag acacagtgac   3000

catgtgaaat atatatgtaa aatgtctggc aaacatctga ttcatgtagg tacccaaaat   3060

tagatcattt tcattttctt ttgcttcctt ggaagttcaa aacaaaattc tgaggtaagt   3120

ttcaattaaa atgggtcagg cagacagatt ccagcaaggt caaagcatcc ttttttcttt   3180

aataaaatat ctgaatatct gaacaagaaa caacttctgt ttctcaaggt tgaaatgatg   3240

aattattgaa cttctgttgc tgtttgtttt ctctcttatc tccttactac tacatataaa   3300

tgagatatct tgctatccca ctgatatctc aaattcagta tttcccaaat aaaacgtaat   3360

cttttccaac                                                          3370


<210>  470
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  470

Met Asn Val Ala Phe Ile Tyr Cys Lys Ile Lys Asp Gly Asp Gly Gln 
1               5                   10                  15      


Gly Val Thr Ala Ser Leu Phe Leu Ala Leu Ile Ile Phe Leu Asp Ile 
            20                  25                  30          


Lys Ser His His Leu Phe Pro Thr Lys Lys Glu Arg Gln Asp His Gln 
        35                  40                  45              


Thr Leu Gln Gly Ser Gln Glu Glu Glu Gly Lys Glu Pro Arg Asn Gly 
    50                  55                  60                  


Glu Lys Leu Asp Ser Arg Asp Gly Ser Gly Asp Ala Pro Gln Ser Ala 
65                  70                  75                  80  


Ala Val Glu Asn Ala Glu Glu Glu Leu Ala Ser Gly Thr Phe Pro Leu 
                85                  90                  95      


Arg Ser Met Ala Gly Gly Met Ser Asn Ile His 
            100                 105         


<210>  471
<211>  1873
<212>  DNA
<213>  Homosapiens

<400>  471
tttttcctgc ttcctcttat taatgaacga gtatttgcat accaaaacat ttgcagagaa     60

gagattcaga caggattagg tggctttatc ggtggtggtg aggttgtggg gcgggggtat    120

ttttcttgga gcttggtgta ttcctgaatc catcagatgt tggtgtccgc gtggatgact    180

aggaaaaggg gattggagat taggtttctt ctacttggag ttctctgctg cttgtttgag    240

cttaataagc ctcctgaaga agttgaagca atttattgct agaggagccc caatgtataa    300

tctccctttc attctctact gtggagaggt gtgctaaacc tgtagagctg tttttgcttc    360

actcggctca tacttaatga tcaacaagta tggtgtgaga tggtaacctc agataaccat    420

tttaaatctg cctttgtttg ctcatatact ctgtctccta atgattcagc acaacaaaca    480

ttccagagag aaaaaacaaa agagtttctg gaggctgctc acattccttg gcttatggcc    540

tccttcttcc aacgtcaaag ccagcaacat tgcagcaatc tgacttattt tgttgtcatg    600

tctcctgacc acatctggaa gggttatcta cttttgaaga cacatccaga taattcagga    660

caatctgtcc attttgaggt tcttcattga atcatgtctg caaagtccct tctgcaatct    720

aagtaagaaa aatcaccaag aatattattt ttggtatttg gaattgaatt tgccaggaat    780

gcaagcactg ctacctaact aaagaccttg gctttggaaa catcttaccc cttggcagct    840

ctccagagtt tagacttggc agcatcaaag acacaacgca aggtgtgttt atttgattta    900

acattttgca aaaggtgttt tgatttgtgg tttgttttct ttcactttgt acttattgct    960

ttgggttgtt tttttctggc aatgaacctg ggttccaagc ataggttttt cttatggaag   1020

gcagttttac aataaggaaa tgtttttact tgtatttatt ttgtgatatt tcagcaaatc   1080

caaataaatg tagtaacatt tataaagcta tacatttata actgatttat ttgttaaata   1140

tttagtatta tcaattgtct gttaaagatt tgttgctaca ttaaatgctt ggtctgtctt   1200

gatgttcagt acattattat actttggtat attgcaatat tttgataatt atgtattggt   1260

tttagtcact gttcctgcat attaagtaat aaacagatta atatcatcat aaaatatcat   1320

ttactcagca atatttctta gtaaattgat acatccattt ttcttatgta ttgtggagag   1380

aggaaatatg acataaaatg gaagaatatg ggcctctgtt tatctctgac ctcatcgctt   1440

actgttcttt cccactcctc actctactca aagcctttaa atagctctcc attttactca   1500

acatcaaatc taaataaagc tcttaaactg gtctaaatgt ctctacagta cttgaacctt   1560

tgttatttct ctaatttcat cttcaactct gctcatcgtt attctcttgc cctgggcata   1620

ctgcctccct ttttgttctc tgaacgtgcc aggcattttc tcatctcaga atttttgcac   1680

ttgctattct ttctactgaa ttgctcttca tccatatata gcaattgtat gaccaatttc   1740

cttacttttc ttttggtcgt tattaaaatt tcaccttcta aatggagtct tacctgatga   1800

ccatccaaag ctttatattc tttctttgct ctataatttt tatcactatc tattaaacta   1860

tatatttaca ctt                                                      1873


<210>  472
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  472

Met Val Thr Ser Asp Asn His Phe Lys Ser Ala Phe Val Cys Ser Tyr 
1               5                   10                  15      


Thr Leu Ser Pro Asn Asp Ser Ala Gln Gln Thr Phe Gln Arg Glu Lys 
            20                  25                  30          


Thr Lys Glu Phe Leu Glu Ala Ala His Ile Pro Trp Leu Met Ala Ser 
        35                  40                  45              


Phe Phe Gln Arg Gln Ser Gln Gln His Cys Ser Asn Leu Thr Tyr Phe 
    50                  55                  60                  


Val Val Met Ser Pro Asp His Ile Trp Lys Gly Tyr Leu Leu Leu Lys 
65                  70                  75                  80  


Thr His Pro Asp Asn Ser Gly Gln Ser Val His Phe Glu Val Leu His 
                85                  90                  95      


<210>  473
<211>  1648
<212>  DNA
<213>  Homosapiens

<400>  473
gagtacggac tgggcctggc ctggggcgtc cccgcgaagc ctgggcctgt caggcggttc     60

cgtccgggtc tcggccaccg tcgagttccg tcgagttccg tcccggccct gctcacagca    120

gcgccctcgg agcgcccagc acctgcggcc ggccaggcag cgcgatcctg cggcgtctgg    180

ccatcccgaa tgctatggcc gccgtcgccg tcttgcgggc cttcggggca agtgggccca    240

tgtgtctccg gcgcggcccc tgggcccagc tccccgcccg cttctgcagc cgggacccgg    300

ccggggcggg gcggcgggag tcggagccgc ggcccaccag cgcgcggcag ctggacggca    360

taaggaacat cgtcttgagc aatcccaaga agaggaacac gttgtcactt gcaatgctga    420

aatctctcca aagtgacatt cttcatgacg ctgacagcaa cgatctgaaa gtcattatca    480

tctcggctga ggggcctgtg ttttcttctg ggcatgactt aaaggagctg acagaggagc    540

aaggccgtga ttaccatgcc gaagtatttc agacctgttc caaggtcatg atgcacatcc    600

ggaaccaccc cgtccccgtc attgccatgg tcaatggcct ggccacggct gccggctgtc    660

aactggttgc cagctgcgac attgccgtgg cgagcgacaa gtcctctttt gccactcctg    720

gggtgaacgt cgggctcttc tgttctaccc ctggggttgc cttggcaaga gcagtgccta    780

gaaaggtggc cttggagatg ctctttactg gtgagcccat ttctgcccag gaggccctgc    840

tccacgggct gcttagcaag gtggtgccag aggcggagct gcaggaggag accatgcgga    900

tcgctaggaa gatcgcatcg ctgagccgtc cggtggtatc cctgggcaaa gccaccttct    960

acaagcagct gccccaggac ctggggacag cttactacct cacctcccag gccatggtgg   1020

acaacctggc cctgcgggac gggcaggagg gcatcacggc cttcctccag aagagaaaac   1080

ctgtctggtc acacgagcca gtgtgagtgg aggcagagga gtgaggccca cgggcagcgc   1140

ccaggagccc accttcccct ctggcccagc caccactgcc tctcagctta aacaggtgac   1200

aggctgcttt cgtgacttga tattggtgtc atagcatttg gcctacatta aaagccacaa   1260

tttcatgggg aaaggacaaa atggagggtg actgaggtgc tgacctcaat gcaaggctgg   1320

tgaaccctgc agcgggccag ctatggtggg aagcctggca tttggggtgc tccttgcaac   1380

gtcttaagca agcgaccccc ctgacatagc aaaaggtggc aacccatgga ggcagaaaga   1440

aggacgccag cctgaccctt atctgaaacg tcctaagcag agttaatcct ggctgctcag   1500

gagaggcgac acatttcaaa tctccacgag atattctcca cacagaaaat cttcttgatt   1560

ctatagagac ttaatcatgc ctatggcttt gaataatctt atgtgattta aataaattaa   1620

atctttataa aaaaaaaaaa aaaaaaaa                                      1648


<210>  474
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  474

Met Ala Ala Val Ala Val Leu Arg Ala Phe Gly Ala Ser Gly Pro Met 
1               5                   10                  15      


Cys Leu Arg Arg Gly Pro Trp Ala Gln Leu Pro Ala Arg Phe Cys Ser 
            20                  25                  30          


Arg Asp Pro Ala Gly Ala Gly Arg Arg Glu Ser Glu Pro Arg Pro Thr 
        35                  40                  45              


Ser Ala Arg Gln Leu Asp Gly Ile Arg Asn Ile Val Leu Ser Asn Pro 
    50                  55                  60                  


Lys Lys Arg Asn Thr Leu Ser Leu Ala Met Leu Lys Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Ile Leu His Asp Ala Asp Ser Asn Asp Leu Lys Val Ile Ile Ile 
                85                  90                  95      


Ser Ala Glu Gly Pro Val Phe Ser Ser Gly His Asp Leu Lys Glu Leu 
            100                 105                 110         


Thr Glu Glu Gln Gly Arg Asp Tyr His Ala Glu Val Phe Gln Thr Cys 
        115                 120                 125             


Ser Lys Val Met Met His Ile Arg Asn His Pro Val Pro Val Ile Ala 
    130                 135                 140                 


Met Val Asn Gly Leu Ala Thr Ala Ala Gly Cys Gln Leu Val Ala Ser 
145                 150                 155                 160 


Cys Asp Ile Ala Val Ala Ser Asp Lys Ser Ser Phe Ala Thr Pro Gly 
                165                 170                 175     


Val Asn Val Gly Leu Phe Cys Ser Thr Pro Gly Val Ala Leu Ala Arg 
            180                 185                 190         


Ala Val Pro Arg Lys Val Ala Leu Glu Met Leu Phe Thr Gly Glu Pro 
        195                 200                 205             


Ile Ser Ala Gln Glu Ala Leu Leu His Gly Leu Leu Ser Lys Val Val 
    210                 215                 220                 


Pro Glu Ala Glu Leu Gln Glu Glu Thr Met Arg Ile Ala Arg Lys Ile 
225                 230                 235                 240 


Ala Ser Leu Ser Arg Pro Val Val Ser Leu Gly Lys Ala Thr Phe Tyr 
                245                 250                 255     


Lys Gln Leu Pro Gln Asp Leu Gly Thr Ala Tyr Tyr Leu Thr Ser Gln 
            260                 265                 270         


Ala Met Val Asp Asn Leu Ala Leu Arg Asp Gly Gln Glu Gly Ile Thr 
        275                 280                 285             


Ala Phe Leu Gln Lys Arg Lys Pro Val Trp Ser His Glu Pro Val 
    290                 295                 300             


<210>  475
<211>  3380
<212>  DNA
<213>  Homosapiens

<400>  475
gggcggcggc gtgagggctc cgggtcgctg gcggcgtgga cacctgagtc ccggggtagg     60

ggtctcccgc gaggagtgag ctgttgccgc agaatgggct gctggctcct gccctgcttc    120

ctgtgatcga gccggccctg aggactctgt ggagatgcct gtaacccacc ggaaatcaga    180

cgcatctgac atgaactcag acacgtcccc cagctgcagg ctccgagcct tcagcagagg    240

cggcagcctg gagagtcgaa gcagcagctc tcgctccaga agcttcactt tggatgatga    300

gagcctgaag tacctcaccc atgaggaaaa ggatgtgctc ctgttttttg aagagacgat    360

tgactcccta gacgaggact ttgaggagcc agtgctgtgc gatggaggag tgtgctgcct    420

ctgctccccg tctctggagg agagcacctc cagtccctcc gagcctgaag atgtcatcga    480

cttagtgcag ccagcacctg gcgccgggga agccgagggc cttccagagg ggacccaggc    540

agcagggcct gcacctgctg ggaaggagca caggaaacaa gatgctgaga ctcctccacc    600

tccagacccc ccggctcccg agacccttct tgcgccacca cccctgccta gcacccccga    660

tccccccagg agggagctgc gcgccccctc cccgccggtg gagcacccca gactcctgcg    720

ctctgttccc acgcccctcg ttatggcgca gaagatttcc gagaggatgg cggggaacga    780

agccctctcg cccacctccc cgttcaggga gggccggccc ggggagtgga ggacacctgc    840

cgcccggggg ccccgcagtg gagaccctgg cccggggccc agccacccgg cgcagcccaa    900

ggcaccccgc ttccccagca acatcatcgt caccaacggc gcggcccggg agccccgcag    960

gaccctgtcc agggcggccg tcagcgtgca ggagcgcagg gcgcaggtgt tggccaccat   1020

ccacggccac gccggcgcct tccccgccgc gggggacgcc ggcgaggggg ccccaggggg   1080

cggctcctcc ccggagcggg tggcgcgtgg ccggggcctg cggggccccg ctgagagtct   1140

ccgggcaggg ggtcaggctc cgcggggccc ggcgctggcc aacggcttcc caagtgcgca   1200

cgaggccctg aagagcgcac ccagctcctt cgcgcccgct gggaagtccc tctgcttccg   1260

ccctggcccg gccctgccca gcacgcgggc ccgtcagagc ttccccgggc cccggcagcc   1320

caacggcgcc caggactggc gccgcgcaga ctccctgccc cggccccagg gcatcaccgt   1380

gcagttcgcg ggccgcggct cctcggagga ggcgcgcagg gaggccctgc ggaagctggg   1440

gctgctcagg gagagttcgt gagggccgcg cgggctccag tccaccccgt ttctccccac   1500

cctgaagaga gggtgaaaga gtcgctgcac ccaggagctg tttggtctaa aatggaagtg   1560

acagcgggag cccctgccct ctgtggcaca tcggagtcta gaggtgcctg gctggggcct   1620

cctggctgag cacgcaccgc aagctccagc caccggcaca gagaactctt ccctaaagga   1680

atctggccga gggcttgtct cccttttccc aagaactgag agagagagaa taacctgtta   1740

gacccatagg tttccgtgat gtgtaaatgc catcttttgg gggttgggag gagtaggact   1800

ggtctgatta tcattcttga gtctcatcta ccctcttctc gaagtacatg acatgaaagt   1860

tcagatccct tccactcagg attctcgccg ccttttctaa gaaaataata aaaaaaaatg   1920

cttgtttcat tttttaatgt cttaatatac ttgcttttgt ttttgaaggg tgaggcatca   1980

tggtactttg cttttgtttc ttgacgtact ttagtttgcc cagttttgtt ttttactgaa   2040

aactgaaatg aaacctttag atattgagtt ttgggagtga aatggaaagg tggtaatttt   2100

gagaaagcaa gtctcatcag actctgaggt ctgggacgtg tgcgtgagcc tgtgtttgtg   2160

tgtgtatgtt tttagatacg tacgtgtcaa cacatacatg cataggtatc ctgtgtgtcc   2220

acatgcatca ttattatata aatagaaact tctgaacacc ctcctaagtc actacaggat   2280

gccagcgctt cctattcttg ggtagacaga gccacctcag catcctgatg gatgatacaa   2340

gaaattgtta cttcctagta tggaagtgtc ttaaggacac gtctccatga tattttggtg   2400

aacccaaagt gctttatcct caacaaaatg ttcctctgtt cccagttaaa gtaatattcc   2460

ctgcttccaa gtaagcaaga ctgttcacta aagaaggaac tttttagaaa actaatctcc   2520

tttatcatcc aattttagtt ctgcatgttc cgaggtagcc agtcaacaga aggaagcaaa   2580

agattcttaa agatccaccg actgtcatgt tccacaagca agatctcagg gtagggaaaa   2640

accagtgaat gaggttacac agcaggaaaa gaaccggttt cctcccagac tatgtcttac   2700

acgctgagtt atgccacaag cgttatcatc aaaactattt aaggctggag tcttagacct   2760

ctaaaaatag acaggaaggg ctgccctgag cagtgacacc tttgtgtttt tatgtctccg   2820

ccagcgccgt aacagagcct gtttctttcc cgttgagtat tacttaaatt caggcttaaa   2880

tgtgctatga agggcatttt tcatagtatc ccatttgcct tgtaagttat ataaagtgca   2940

tgattataat tttttcctta gaaatgcaat atttagtttc atccagctct tatgaataat   3000

aacctcatag attcctgatc ttaatttaaa taggtgcttt aattttacag ctttcaaaag   3060

tagttactgt aaattttact cctgttaatg ctggattggt ttaaaggatt tataagggct   3120

gtgtttgctc tttacaaggc aagatgccat acagtgttca ataatagaag gtcttgatac   3180

aaccgacatt ttaaatattc tttatacatg aggactgcgt ctttttcact gaccctatga   3240

tttcactgtg agtagggtga actggactgc atattagttt atttgttgcc ataatcacat   3300

ttttgaaaaa taaatttaag agttttttct taaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3360

aaaaaaaaaa aaaaaaaaaa                                               3380


<210>  476
<211>  435
<212>  PRT
<213>  Homosapiens

<400>  476

Met Pro Val Thr His Arg Lys Ser Asp Ala Ser Asp Met Asn Ser Asp 
1               5                   10                  15      


Thr Ser Pro Ser Cys Arg Leu Arg Ala Phe Ser Arg Gly Gly Ser Leu 
            20                  25                  30          


Glu Ser Arg Ser Ser Ser Ser Arg Ser Arg Ser Phe Thr Leu Asp Asp 
        35                  40                  45              


Glu Ser Leu Lys Tyr Leu Thr His Glu Glu Lys Asp Val Leu Leu Phe 
    50                  55                  60                  


Phe Glu Glu Thr Ile Asp Ser Leu Asp Glu Asp Phe Glu Glu Pro Val 
65                  70                  75                  80  


Leu Cys Asp Gly Gly Val Cys Cys Leu Cys Ser Pro Ser Leu Glu Glu 
                85                  90                  95      


Ser Thr Ser Ser Pro Ser Glu Pro Glu Asp Val Ile Asp Leu Val Gln 
            100                 105                 110         


Pro Ala Pro Gly Ala Gly Glu Ala Glu Gly Leu Pro Glu Gly Thr Gln 
        115                 120                 125             


Ala Ala Gly Pro Ala Pro Ala Gly Lys Glu His Arg Lys Gln Asp Ala 
    130                 135                 140                 


Glu Thr Pro Pro Pro Pro Asp Pro Pro Ala Pro Glu Thr Leu Leu Ala 
145                 150                 155                 160 


Pro Pro Pro Leu Pro Ser Thr Pro Asp Pro Pro Arg Arg Glu Leu Arg 
                165                 170                 175     


Ala Pro Ser Pro Pro Val Glu His Pro Arg Leu Leu Arg Ser Val Pro 
            180                 185                 190         


Thr Pro Leu Val Met Ala Gln Lys Ile Ser Glu Arg Met Ala Gly Asn 
        195                 200                 205             


Glu Ala Leu Ser Pro Thr Ser Pro Phe Arg Glu Gly Arg Pro Gly Glu 
    210                 215                 220                 


Trp Arg Thr Pro Ala Ala Arg Gly Pro Arg Ser Gly Asp Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Ser His Pro Ala Gln Pro Lys Ala Pro Arg Phe Pro Ser Asn 
                245                 250                 255     


Ile Ile Val Thr Asn Gly Ala Ala Arg Glu Pro Arg Arg Thr Leu Ser 
            260                 265                 270         


Arg Ala Ala Val Ser Val Gln Glu Arg Arg Ala Gln Val Leu Ala Thr 
        275                 280                 285             


Ile His Gly His Ala Gly Ala Phe Pro Ala Ala Gly Asp Ala Gly Glu 
    290                 295                 300                 


Gly Ala Pro Gly Gly Gly Ser Ser Pro Glu Arg Val Ala Arg Gly Arg 
305                 310                 315                 320 


Gly Leu Arg Gly Pro Ala Glu Ser Leu Arg Ala Gly Gly Gln Ala Pro 
                325                 330                 335     


Arg Gly Pro Ala Leu Ala Asn Gly Phe Pro Ser Ala His Glu Ala Leu 
            340                 345                 350         


Lys Ser Ala Pro Ser Ser Phe Ala Pro Ala Gly Lys Ser Leu Cys Phe 
        355                 360                 365             


Arg Pro Gly Pro Ala Leu Pro Ser Thr Arg Ala Arg Gln Ser Phe Pro 
    370                 375                 380                 


Gly Pro Arg Gln Pro Asn Gly Ala Gln Asp Trp Arg Arg Ala Asp Ser 
385                 390                 395                 400 


Leu Pro Arg Pro Gln Gly Ile Thr Val Gln Phe Ala Gly Arg Gly Ser 
                405                 410                 415     


Ser Glu Glu Ala Arg Arg Glu Ala Leu Arg Lys Leu Gly Leu Leu Arg 
            420                 425                 430         


Glu Ser Ser 
        435 


<210>  477
<211>  3262
<212>  DNA
<213>  Homosapiens

<400>  477
gcggcggggc tggcagcagt ggctgcccgc actgcgcccg ggcgctcgcc ttcgctgcag     60

ctcccggtgc cgccgctcgg gccggccccc cggcaggccc tcctcgttat ggccgcggcc    120

tcctccccgc ccagggccga gaggaagcgc tggggttggg gccgcctgcc aggcgcccgg    180

cggggcagcg cgggcctggc caagaagtgc cccttctcgc tggagctggc ggagggcggc    240

ccggcgggcg gcgcgctcta cgcgcccatc gcgcccggcg ccccaggtcc cgcgccccct    300

gcgtccccgg ccgcgcccgc cgcgccccca gttgcctccg accttggccc gcggccgccg    360

gtgagcctag acccgcgcgt ctccatctac agcacgcgcc gcccggtgtt ggcgcgcacc    420

cacgtccagg gccgcgtcta caacttcctc gagcgtccca ccggctggaa atgcttcgtt    480

taccacttcg ccgtcttcct catcgtcctg gtctgcctca tcttcagcgt gctgtccacc    540

atcgagcagt atgccgccct ggccacgggg actctcttct ggatggagat cgtgctggtg    600

gtgttcttcg ggacggagta cgtggtccgc ctctggtccg ccggctgccg cagcaagtac    660

gtgggcctct gggggcggct gcgctttgcc cggaagccca tttccatcat cgacctcatc    720

gtggtcgtgg cctccatggt ggtcctctgc gtgggctcca aggggcaggt gtttgccacg    780

tcggccatca ggggcatccg cttcctgcag atcctgagga tgctacacgt cgaccgccag    840

ggaggcacct ggaggctcct gggctccgtg gtcttcatcc accgccagga gctgataacc    900

accctgtaca tcggcttcct gggcctcatc ttctcctcgt actttgtgta cctggctgag    960

aaggacgcgg tgaacgagtc aggccgcgtg gagttcggca gctacgcaga tgcgctgtgg   1020

tggggggtgg tcacagtcac caccatcggc tatggggaca aggtgcccca gacgtgggtc   1080

gggaagacca tcgcctcctg cttctctgtc tttgccatct ccttctttgc gctcccagcg   1140

gggattcttg gctcggggtt tgccctgaag gtgcagcaga agcagaggca gaagcacttc   1200

aaccggcaga tcccggcggc agcctcactc attcagaccg catggaggtg ctatgctgcc   1260

gagaaccccg actcctccac ctggaagatc tacatccgga aggccccccg gagccacact   1320

ctgctgtcac ccagccccaa acccaagaag tctgtggtgg taaagaaaaa aaagttcaag   1380

ctggacaaag acaatggggt gactcctgga gagaagatgc tcacagtccc ccatatcacg   1440

tgcgaccccc cagaagagcg gcggctggac cacttctctg tcgacggcta tgacagttct   1500

gtaaggaaga gcccaacact gctggaagtg agcatgcccc atttcatgag aaccaacagc   1560

ttcgccgagg acctggacct ggaaggggag actctgctga cacccatcac ccacatctca   1620

cagctgcggg aacaccatcg ggccaccatt aaggtcattc gacgcatgca gtactttgtg   1680

gccaagaaga aattccagca agcgcggaag ccttacgatg tgcgggacgt cattgagcag   1740

tactcgcagg gccacctcaa cctcatggtg cgcatcaagg agctgcagag gaggctggac   1800

cagtccattg ggaagccctc actgttcatc tccgtctcag aaaagagcaa ggatcgcggc   1860

agcaacacga tcggcgcccg cctgaaccga gtagaagaca aggtgacgca gctggaccag   1920

aggctggcac tcatcaccga catgcttcac cagctgctct ccttgcacgg tggcagcacc   1980

cccggcagcg gcggcccccc cagagagggc ggggcccaca tcacccagcc ctgcggcagt   2040

ggcggctccg tcgaccctga gctcttcctg cccagcaaca ccctgcccac ctacgagcag   2100

ctgaccgtgc ccaggagggg ccccgatgag gggtcctgag gaggggatgg ggctggggga   2160

tgggcctgag tgagagggga ggccaagagt ggccccacct ggccctctct gaaggaggcc   2220

acctcctaaa aggcccagag agaagagccc cactctcaga ggccccaata ccccatggac   2280

catgctgtct ggcacagcct gcacttgggg gctcagcaag gccacctctt cctggccggt   2340

gtgggggccc cgtctcaggt ctgagttgtt accccaagcg ccctggcccc cacatggtga   2400

tgttgacatc actggcatgg tggttgggac ccagtggcag ggcacagggc ctggcccatg   2460

tatggccagg aagtagcaca ggctgagtgc aggcccaccc tgcttggccc agggggcttc   2520

ctgaggggag acagagcaac ccctggaccc cagcctcaaa tccaggaccc tgccaggcac   2580

aggcagggca ggaccagccc acgctgacta cagggccgcc ggcaataaaa gcccaggagc   2640

ccatttggag ggcctgggcc tggctccctc actctcagga aatgctgacc catgggcagg   2700

agactgtgga gactgctcct gagcccccag cttccagcag gagggacagt ctcaccattt   2760

ccccagggca cgtggttgag tggggggaac gcccacttcc ctgggttaga ctgccagctc   2820

ttcctagctg gagaggagcc ctgcctctcc gcccctgagc ccactgtgcg tggggctccc   2880

gcctccaacc cctcgcccag tcccagcagc cagccaaaca cacagaaggg gactgccacc   2940

tccccttgcc agctgctgag ccgcagagaa gtgacggttc ctacacagga caggggttcc   3000

ttctgggcat tacatcgcat agaaatcaat aatttgtggt gatttggatc tgtgttttaa   3060

tgagtttcac agtgtgattt tgattattaa ttgtgcaagc ttttcctaat aaacgtggag   3120

aatcacaggc tgggctgggc actgctctca ccttggttcc tggggcatcc atggggtctc   3180

tcacagacag gacccctgca gttcccctgg aagcagtgcc caggtggctg tggaatagga   3240

acgctaaaaa aaaaaaaaaa aa                                            3262


<210>  478
<211>  676
<212>  PRT
<213>  Homosapiens

<400>  478

Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu 
145                 150                 155                 160 


Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp 
                165                 170                 175     


Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg 
            180                 185                 190         


Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala 
        195                 200                 205             


Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr 
    210                 215                 220                 


Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His 
225                 230                 235                 240 


Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe 
                245                 250                 255     


Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly 
            260                 265                 270         


Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val 
        275                 280                 285             


Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp 
    290                 295                 300                 


Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro 
305                 310                 315                 320 


Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala 
                325                 330                 335     


Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 
            340                 345                 350         


Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala 
    370                 375                 380                 


Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro 
385                 390                 395                 400 


Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val 
                405                 410                 415     


Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr 
            420                 425                 430         


Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro 
        435                 440                 445             


Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser 
    450                 455                 460                 


Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met 
465                 470                 475                 480 


Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu 
                485                 490                 495     


Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala 
            500                 505                 510         


Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys 
        515                 520                 525             


Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln 
    530                 535                 540                 


Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln 
545                 550                 555                 560 


Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val 
                565                 570                 575     


Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu 
            580                 585                 590         


Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu 
        595                 600                 605             


Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr 
    610                 615                 620                 


Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln 
625                 630                 635                 640 


Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser 
                645                 650                 655     


Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro 
            660                 665                 670         


Asp Glu Gly Ser 
        675     


<210>  479
<211>  3023
<212>  DNA
<213>  Homosapiens

<400>  479
ttgcctccga ccttggcccg cggccgccgg tgagcctaga cccgcgcgtc tccatctaca     60

gcacgcgccg cccggtgttg gcgcgcaccc acgtccaggg ccgcgtctac aacttcctcg    120

agcgtcccac cggctggaaa tgcttcgttt accacttcgc cgtattcaag aaattaagca    180

tacggtcacg agagtgcaaa gttctgtgaa acgctccagt ggttacacgc cccggggttt    240

cagcttcgac cctggcttcc tcatcgtcct ggtctgcctc atcttcagcg tgctgtccac    300

catcgagcag tatgccgccc tggccacggg gactctcttc tggatggaga tcgtgctggt    360

ggtgttcttc cggacggagt acgtggtccg cctctggtcc gccggctgcc gcagcaagta    420

cgtgggcctc tgggggcggc tgcgctttgc ccggaagccc atttccatca tcgacctcat    480

cgtggtcgtg gcctccatgg tggtcctctg cgtgggctcc aaggggcagg tgtttgccac    540

gtcggccatc aggggcatcc gcttcctgca gatcctgagg atgctacacg tcgaccgcca    600

gggaggcacc tggaggctcc tgggctccgt ggtcttcatc caccgccagg agctgataac    660

caccctgtac atcggcttcc tgggcctcat cttctcctcg tactttgtgt acctggctga    720

gaaggacgcg gtgaacgagt caggccgcgt ggagttcggc agctacgcag atgcgctgtg    780

gtggggggtg gtcacagtca ccaccatcgg ctatggggac aaggtgcccc agacgtgggt    840

cgggaagacc atcgcctcct gcttctctgt ctttgccatc tccttctttg cgctcccagc    900

ggggattctt ggctcggggt ttgccctgaa ggtgcagcag aagcagaggc agaagcactt    960

caaccggcag atcccggcgg cagcctcact cattcagacc gcatggaggt gctatgctgc   1020

cgagaacccc gactcctcca cctggaagat ctacatccgg aaggcccccc ggagccacac   1080

tctgctgtca cccagcccca aacccaagaa gtctgtggtg gtaaagaaaa aaaagttcaa   1140

gctggacaaa gacaatgggg tgactcctgg agagaagatg ctcacagtcc cccatatcac   1200

gtgcgacccc ccagaagagc ggcggctgga ccacttctct gtcgacggct atgacagttc   1260

tgtaaggaag agcccaacac tgctggaagt gagcatgccc catttcatga gaaccaacag   1320

cttcgccgag gacctggacc tggaagggga gactctgctg acacccatca cccacatctc   1380

acagctgcgg gaacaccatc gggccaccat taaggtcatt cgacgcatgc agtactttgt   1440

ggccaagaag aaattccagc aagcgcggaa gccttacgat gtgcgggacg tcattgagca   1500

gtactcgcag ggccacctca acctcatggt gcgcatcaag gagctgcaga ggaggctgga   1560

ccagtccatt gggaagccct cactgttcat ctccgtctca gaaaagagca aggatcgcgg   1620

cagcaacacg atcggcgccc gcctgaaccg agtagaagac aaggtgacgc agctggacca   1680

gaggctggca ctcatcaccg acatgcttca ccagctgctc tccttgcacg gtggcagcac   1740

ccccggcagc ggcggccccc ccagagaggg cggggcccac atcacccagc cctgcggcag   1800

tggcggctcc gtcgaccctg agctcttcct gcccagcaac accctgccca cctacgagca   1860

gctgaccgtg cccaggaggg gccccgatga ggggtcctga ggaggggatg gggctggggg   1920

atgggcctga gtgagagggg aggccaagag tggccccacc tggccctctc tgaaggaggc   1980

cacctcctaa aaggcccaga gagaagagcc ccactctcag aggccccaat accccatgga   2040

ccatgctgtc tggcacagcc tgcacttggg ggctcagcaa ggccacctct tcctggccgg   2100

tgtgggggcc ccgtctcagg tctgagttgt taccccaagc gccctggccc ccacatggtg   2160

atgttgacat cactggcatg gtggttggga cccagtggca gggcacaggg cctggcccat   2220

gtatggccag gaagtagcac aggctgagtg caggcccacc ctgcttggcc cagggggctt   2280

cctgagggga gacagagcaa cccctggacc ccagcctcaa atccaggacc ctgccaggca   2340

caggcagggc aggaccagcc cacgctgact acagggccgc cggcaataaa agcccaggag   2400

cccatttgga gggcctgggc ctggctccct cactctcagg aaatgctgac ccatgggcag   2460

gagactgtgg agactgctcc tgagccccca gcttccagca ggagggacag tctcaccatt   2520

tccccagggc acgtggttga gtggggggaa cgcccacttc cctgggttag actgccagct   2580

cttcctagct ggagaggagc cctgcctctc cgcccctgag cccactgtgc gtggggctcc   2640

cgcctccaac ccctcgccca gtcccagcag ccagccaaac acacagaagg ggactgccac   2700

ctccccttgc cagctgctga gccgcagaga agtgacggtt cctacacagg acaggggttc   2760

cttctgggca ttacatcgca tagaaatcaa taatttgtgg tgatttggat ctgtgtttta   2820

atgagtttca cagtgtgatt ttgattatta attgtgcaag cttttcctaa taaacgtgga   2880

gaatcacagg ctgggctggg cactgctctc accttggttc ctggggcatc catggggtct   2940

ctcacagaca ggacccctgc agttcccctg gaagcagtgc ccaggtggct gtggaatagg   3000

aacgctaaaa aaaaaaaaaa aaa                                           3023


<210>  480
<211>  586
<212>  PRT
<213>  Homosapiens

<400>  480

Met Leu Arg Leu Pro Leu Arg Arg Ile Gln Glu Ile Lys His Thr Val 
1               5                   10                  15      


Thr Arg Val Gln Ser Ser Val Lys Arg Ser Ser Gly Tyr Thr Pro Arg 
            20                  25                  30          


Gly Phe Ser Phe Asp Pro Gly Phe Leu Ile Val Leu Val Cys Leu Ile 
        35                  40                  45              


Phe Ser Val Leu Ser Thr Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly 
    50                  55                  60                  


Thr Leu Phe Trp Met Glu Ile Val Leu Val Val Phe Phe Arg Thr Glu 
65                  70                  75                  80  


Tyr Val Val Arg Leu Trp Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly 
                85                  90                  95      


Leu Trp Gly Arg Leu Arg Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp 
            100                 105                 110         


Leu Ile Val Val Val Ala Ser Met Val Val Leu Cys Val Gly Ser Lys 
        115                 120                 125             


Gly Gln Val Phe Ala Thr Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln 
    130                 135                 140                 


Ile Leu Arg Met Leu His Val Asp Arg Gln Gly Gly Thr Trp Arg Leu 
145                 150                 155                 160 


Leu Gly Ser Val Val Phe Ile His Arg Gln Glu Leu Ile Thr Thr Leu 
                165                 170                 175     


Tyr Ile Gly Phe Leu Gly Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu 
            180                 185                 190         


Ala Glu Lys Asp Ala Val Asn Glu Ser Gly Arg Val Glu Phe Gly Ser 
        195                 200                 205             


Tyr Ala Asp Ala Leu Trp Trp Gly Val Val Thr Val Thr Thr Ile Gly 
    210                 215                 220                 


Tyr Gly Asp Lys Val Pro Gln Thr Trp Val Gly Lys Thr Ile Ala Ser 
225                 230                 235                 240 


Cys Phe Ser Val Phe Ala Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile 
                245                 250                 255     


Leu Gly Ser Gly Phe Ala Leu Lys Val Gln Gln Lys Gln Arg Gln Lys 
            260                 265                 270         


His Phe Asn Arg Gln Ile Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala 
        275                 280                 285             


Trp Arg Cys Tyr Ala Ala Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile 
    290                 295                 300                 


Tyr Ile Arg Lys Ala Pro Arg Ser His Thr Leu Leu Ser Pro Ser Pro 
305                 310                 315                 320 


Lys Pro Lys Lys Ser Val Val Val Lys Lys Lys Lys Phe Lys Leu Asp 
                325                 330                 335     


Lys Asp Asn Gly Val Thr Pro Gly Glu Lys Met Leu Thr Val Pro His 
            340                 345                 350         


Ile Thr Cys Asp Pro Pro Glu Glu Arg Arg Leu Asp His Phe Ser Val 
        355                 360                 365             


Asp Gly Tyr Asp Ser Ser Val Arg Lys Ser Pro Thr Leu Leu Glu Val 
    370                 375                 380                 


Ser Met Pro His Phe Met Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp 
385                 390                 395                 400 


Leu Glu Gly Glu Thr Leu Leu Thr Pro Ile Thr His Ile Ser Gln Leu 
                405                 410                 415     


Arg Glu His His Arg Ala Thr Ile Lys Val Ile Arg Arg Met Gln Tyr 
            420                 425                 430         


Phe Val Ala Lys Lys Lys Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val 
        435                 440                 445             


Arg Asp Val Ile Glu Gln Tyr Ser Gln Gly His Leu Asn Leu Met Val 
    450                 455                 460                 


Arg Ile Lys Glu Leu Gln Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro 
465                 470                 475                 480 


Ser Leu Phe Ile Ser Val Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn 
                485                 490                 495     


Thr Ile Gly Ala Arg Leu Asn Arg Val Glu Asp Lys Val Thr Gln Leu 
            500                 505                 510         


Asp Gln Arg Leu Ala Leu Ile Thr Asp Met Leu His Gln Leu Leu Ser 
        515                 520                 525             


Leu His Gly Gly Ser Thr Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly 
    530                 535                 540                 


Gly Ala His Ile Thr Gln Pro Cys Gly Ser Gly Gly Ser Val Asp Pro 
545                 550                 555                 560 


Glu Leu Phe Leu Pro Ser Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr 
                565                 570                 575     


Val Pro Arg Arg Gly Pro Asp Glu Gly Ser 
            580                 585     


<210>  481
<211>  3029
<212>  DNA
<213>  Homosapiens

<400>  481
gcagcttcca tggcctgggg ctgtgagagg cccgggaagg cactgtcttt gcgcctgcac     60

atgtgtgtgt ctggagtgta ggatggcact ggtgccgggc ctggatttac tcagcccaga    120

tcacggctgc ttttgtttac gtggcccctg ctctcaccca caactccagg tttctggctc    180

tcgggaattt gaggcctgtg gctgctgtgg accctgggaa agagcctgtg cttcctgagc    240

cagtgcgggg cctggcatgg acttcctcat cgtcctggtc tgcctcatct tcagcgtgct    300

gtccaccatc gagcagtatg ccgccctggc cacggggact ctcttctgga tggagatcgt    360

gctggtggtg ttcttcggga cggagtacgt ggtccgcctc tggtccgccg gctgccgcag    420

caagtacgtg ggcctctggg ggcggctgcg ctttgcccgg aagcccattt ccatcatcga    480

cctcatcgtg gtcgtggcct ccatggtggt cctctgcgtg ggctccaagg ggcaggtgtt    540

tgccacgtcg gccatcaggg gcatccgctt cctgcagatc ctgaggatgc tacacgtcga    600

ccgccaggga ggcacctgga ggctcctggg ctccgtggtc ttcatccacc gccaggagct    660

gataaccacc ctgtacatcg gcttcctggg cctcatcttc tcctcgtact ttgtgtacct    720

ggctgagaag gacgcggtga acgagtcagg ccgcgtggag ttcggcagct acgcagatgc    780

gctgtggtgg ggggtggtca cagtcaccac catcggctat ggggacaagg tgccccagac    840

gtgggtcggg aagaccatcg cctcctgctt ctctgtcttt gccatctcct tctttgcgct    900

cccagcgggg attcttggct cggggtttgc cctgaaggtg cagcagaagc agaggcagaa    960

gcacttcaac cggcagatcc cggcggcagc ctcactcatt cagaccgcat ggaggtgcta   1020

tgctgccgag aaccccgact cctccacctg gaagatctac atccggaagg ccccccggag   1080

ccacactctg ctgtcaccca gccccaaacc caagaagtct gtggtggtaa agaaaaaaaa   1140

gttcaagctg gacaaagaca atggggtgac tcctggagag aagatgctca cagtccccca   1200

tatcacgtgc gaccccccag aagagcggcg gctggaccac ttctctgtcg acggctatga   1260

cagttctgta aggaagagcc caacactgct ggaagtgagc atgccccatt tcatgagaac   1320

caacagcttc gccgaggacc tggacctgga aggggagact ctgctgacac ccatcaccca   1380

catctcacag ctgcgggaac accatcgggc caccattaag gtcattcgac gcatgcagta   1440

ctttgtggcc aagaagaaat tccagcaagc gcggaagcct tacgatgtgc gggacgtcat   1500

tgagcagtac tcgcagggcc acctcaacct catggtgcgc atcaaggagc tgcagaggag   1560

gctggaccag tccattggga agccctcact gttcatctcc gtctcagaaa agagcaagga   1620

tcgcggcagc aacacgatcg gcgcccgcct gaaccgagta gaagacaagg tgacgcagct   1680

ggaccagagg ctggcactca tcaccgacat gcttcaccag ctgctctcct tgcacggtgg   1740

cagcaccccc ggcagcggcg gcccccccag agagggcggg gcccacatca cccagccctg   1800

cggcagtggc ggctccgtcg accctgagct cttcctgccc agcaacaccc tgcccaccta   1860

cgagcagctg accgtgccca ggaggggccc cgatgagggg tcctgaggag gggatggggc   1920

tgggggatgg gcctgagtga gaggggaggc caagagtggc cccacctggc cctctctgaa   1980

ggaggccacc tcctaaaagg cccagagaga agagccccac tctcagaggc cccaataccc   2040

catggaccat gctgtctggc acagcctgca cttgggggct cagcaaggcc acctcttcct   2100

ggccggtgtg ggggccccgt ctcaggtctg agttgttacc ccaagcgccc tggcccccac   2160

atggtgatgt tgacatcact ggcatggtgg ttgggaccca gtggcagggc acagggcctg   2220

gcccatgtat ggccaggaag tagcacaggc tgagtgcagg cccaccctgc ttggcccagg   2280

gggcttcctg aggggagaca gagcaacccc tggaccccag cctcaaatcc aggaccctgc   2340

caggcacagg cagggcagga ccagcccacg ctgactacag ggccgccggc aataaaagcc   2400

caggagccca tttggagggc ctgggcctgg ctccctcact ctcaggaaat gctgacccat   2460

gggcaggaga ctgtggagac tgctcctgag cccccagctt ccagcaggag ggacagtctc   2520

accatttccc cagggcacgt ggttgagtgg ggggaacgcc cacttccctg ggttagactg   2580

ccagctcttc ctagctggag aggagccctg cctctccgcc cctgagccca ctgtgcgtgg   2640

ggctcccgcc tccaacccct cgcccagtcc cagcagccag ccaaacacac agaaggggac   2700

tgccacctcc ccttgccagc tgctgagccg cagagaagtg acggttccta cacaggacag   2760

gggttccttc tgggcattac atcgcataga aatcaataat ttgtggtgat ttggatctgt   2820

gttttaatga gtttcacagt gtgattttga ttattaattg tgcaagcttt tcctaataaa   2880

cgtggagaat cacaggctgg gctgggcact gctctcacct tggttcctgg ggcatccatg   2940

gggtctctca cagacaggac ccctgcagtt cccctggaag cagtgcccag gtggctgtgg   3000

aataggaacg ctaaaaaaaa aaaaaaaaa                                     3029


<210>  482
<211>  549
<212>  PRT
<213>  Homosapiens

<400>  482

Met Asp Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser 
1               5                   10                  15      


Thr Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met 
            20                  25                  30          


Glu Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu 
        35                  40                  45              


Trp Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu 
    50                  55                  60                  


Arg Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val 
65                  70                  75                  80  


Ala Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala 
                85                  90                  95      


Thr Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu 
            100                 105                 110         


His Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val 
        115                 120                 125             


Phe Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu 
    130                 135                 140                 


Gly Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala 
145                 150                 155                 160 


Val Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu 
                165                 170                 175     


Trp Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val 
            180                 185                 190         


Pro Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe 
        195                 200                 205             


Ala Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe 
    210                 215                 220                 


Ala Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln 
225                 230                 235                 240 


Ile Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala 
                245                 250                 255     


Ala Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala 
            260                 265                 270         


Pro Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser 
        275                 280                 285             


Val Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val 
    290                 295                 300                 


Thr Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro 
305                 310                 315                 320 


Pro Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser 
                325                 330                 335     


Ser Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe 
            340                 345                 350         


Met Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr 
        355                 360                 365             


Leu Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg 
    370                 375                 380                 


Ala Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys 
385                 390                 395                 400 


Lys Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu 
                405                 410                 415     


Gln Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu 
            420                 425                 430         


Gln Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser 
        435                 440                 445             


Val Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg 
    450                 455                 460                 


Leu Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala 
465                 470                 475                 480 


Leu Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser 
                485                 490                 495     


Thr Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr 
            500                 505                 510         


Gln Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro 
        515                 520                 525             


Ser Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly 
    530                 535                 540                 


Pro Asp Glu Gly Ser 
545                 


<210>  483
<211>  2997
<212>  DNA
<213>  Homosapiens

<400>  483
actaagcccc atcgccttat ttctggggta catccagacc tggcagggat cctgccacac     60

tgtgcagcaa accagcatgt aggctgggta ggagagcaag agatagagcc atcagagtga    120

tggggcttct tcacagtaag aacatcggag cttagaatga gagtctcttt ccaaaaacag    180

gcattgttca tcttacgcta aacatcattg tctgcctggc tacagtcacc aaaacaaaac    240

agaaatgcaa aattatgcat cttcccatag tcctgaggct tcctttgcca atggaagggc    300

tagcaatgca ttctccctct catgaaagtt aaatttccag agacttcctt agattgctca    360

aaatgttaaa gatatgtcca tgtctgcaat tcgccagttt caggtcaagg cctactttca    420

tcaatattgc tcccagaagt tttctgacac cagaatgcca ttcctggtcc cagctctatt    480

tttaggccac cacgataact tctttggttt ctcaactgag catgcaacca tttatttaaa    540

agactgtcat taatgagtag atgttttcgc gggtcgtgtg atgtgctttc catttactag    600

tgttgctgtg gctaagtaca atcaaattga accaccaacc cttggttttg tagtaatata    660

actatttatt ttcctagtgt agatgctttc agattagaat tggcatttgc actgattttt    720

ttatgtagat ttatataaat atatagatac atatatattt gcttgaagaa tcaccaagca    780

aattggtgag agggtctttt ccaatagaat ttacacctcc atttgttgtg ttgtcttgca    840

cttcccaatg ttgatgtctc tatggctcca atgaactggt gtattttgca gcaaatctga    900

tgacttgtat ggaaatggca tgaaagttac ccagattaca tctggtgcaa atgcactcgg    960

agcctggggc cagactggtg ctaacactgc aaactttgtc cagagctctc tccaacctga   1020

aggcttgctg ggggtgcaat gtcaccttca cacatgctgg gccctttcag aaaagtgcca   1080

gatcgtgtaa ctggtgctat ttttcatgct ctggtacaat gtgtagcacc acgggggtct   1140

cagctttacc aaaatcaaaa ttccatttgt cagctaagtg cagaggcatt tgttttttgc   1200

tctcctccca cagaattgtc ggccatttat ttgcaggcct tttgcgggat ttcttggcta   1260

tttatttgca ggcctttttt cccagcccca aattcttggg ttggctctgt ctgcttaaag   1320

agcctgtctt cacaaagctg cactcgggtg cctctgtgcg ctgtcttaga tcctactgcc   1380

ggcccttcag gactccgagc caggaaagaa ctctccaacc tctggctcga gactctactt   1440

tttttctcat tcttttcctt actctcctcc tccttctact tccgactaat tccatctctt   1500

tttttttttt gttcctctcc ttttcctatt cctccttccc accatctctg agttgttgac   1560

tttctcctat aatccttctc tattcccttt ctctttttgt ccacctctcc tttagtctct   1620

gtttctctgc ccttcttatt cctcttctgt cctttctcct ctcctcaaat ctctgatcat   1680

cttctcccgt acatccctgt attgattttt ctgtcctcta aagggctcat ggctgattca   1740

gacagcaagt ccatgcactg gactaatgac acaaatactt taggtcgccg tttcacctac   1800

tcagcccaga aagtaaagct gagcgtgagg ccctgacctg gagcctgctc cagcccgcct   1860

cccggagcca gcctgcaccg ttgccctggc agcgatgatg catgtgctgt gggccctgcc   1920

ggcgcctgag tgcctctgcc tgaacactgc tcctaagcga gcccactccc agcactaccg   1980

catggctctg aggacatttt ctttcaataa aggcagactc tggccccaat tattctgata   2040

gcaaacctct tcctcctcat tgaagccatg ccatcacctt ggtttggaga gagacatttt   2100

tttcccattc ataagctttc tttttcccat ttttatgtga agccccctct gcttttcagc   2160

tggtgattgc tctggtgaga ctgaatggac ttgctggtga aatgaaatct cttctttcct   2220

gtcttggtcc tgcctaaatt cctacaaata tatttaagcc aaggactcag gctaattcct   2280

aagttgatca cattaatttg ttactcctag agggaaaaag atcaattccc ttgaagcatg   2340

tggagtacct cctgtgacag ctgacttgcc aggggactcc ctacagaatt ctgtgatata   2400

cattttactt ctgtgtatgt atggtatata tggtatgtat accatgtaca cacgttacat   2460

tgagtatgaa tgactgtggt tggaaacaca cacacacact caagtctgta aatatccttc   2520

ctcactgaaa cctgtgcttt ggaaatcatt tcttgtacag ctgtgcagtt tcttgtaaca   2580

gctgaggaca aagctaagac aggcggacaa tttagacaaa gatcatctaa agagtatagt   2640

atctccctag caactcatga ggacagacaa ccaagtggca aggttgactc ccaatgggat   2700

ggcagacttt tcttctctcc tttttgagtt tgtgtttcct aagtgtttct taacttctga   2760

gtgcaccagg ctgtacccgt tagatccttt caatatgaca gttttgtgct tctctctgac   2820

aggatgtttc tccaccgagc tgtagcacag gatgggaggg aggtgggaat actccttgcc   2880

taggctggag tttacagaga cactgcacag cttacactcc tgttaagtgt aaatattcaa   2940

cacttccatt ccatttgtgt aaaaaataaa gcacacacga ttataaaatc aagatgt      2997


<210>  484
<211>  202
<212>  PRT
<213>  Homosapiens

<400>  484

Met His Ser Glu Pro Gly Ala Arg Leu Val Leu Thr Leu Gln Thr Leu 
1               5                   10                  15      


Ser Arg Ala Leu Ser Asn Leu Lys Ala Cys Trp Gly Cys Asn Val Thr 
            20                  25                  30          


Phe Thr His Ala Gly Pro Phe Gln Lys Ser Ala Arg Ser Cys Asn Trp 
        35                  40                  45              


Cys Tyr Phe Ser Cys Ser Gly Thr Met Cys Ser Thr Thr Gly Val Ser 
    50                  55                  60                  


Ala Leu Pro Lys Ser Lys Phe His Leu Ser Ala Lys Cys Arg Gly Ile 
65                  70                  75                  80  


Cys Phe Leu Leu Ser Ser His Arg Ile Val Gly His Leu Phe Ala Gly 
                85                  90                  95      


Leu Leu Arg Asp Phe Leu Ala Ile Tyr Leu Gln Ala Phe Phe Pro Ser 
            100                 105                 110         


Pro Lys Phe Leu Gly Trp Leu Cys Leu Leu Lys Glu Pro Val Phe Thr 
        115                 120                 125             


Lys Leu His Ser Gly Ala Ser Val Arg Cys Leu Arg Ser Tyr Cys Arg 
    130                 135                 140                 


Pro Phe Arg Thr Pro Ser Gln Glu Arg Thr Leu Gln Pro Leu Ala Arg 
145                 150                 155                 160 


Asp Ser Thr Phe Phe Leu Ile Leu Phe Leu Thr Leu Leu Leu Leu Leu 
                165                 170                 175     


Leu Pro Thr Asn Ser Ile Ser Phe Phe Phe Leu Phe Leu Ser Phe Ser 
            180                 185                 190         


Tyr Ser Ser Phe Pro Pro Ser Leu Ser Cys 
        195                 200         


<210>  485
<211>  3071
<212>  DNA
<213>  Homosapiens

<400>  485
aaaagcaact gaggtcttaa ctttcagacg ctgaattctc atctaattga aattactggg     60

cataatgcta tatatagcca atgaagagat tttgagctct cactcagtgc cttcaagaca    120

tgtcgttttg tagtcagaga aaacagagat caatgcattt tcaaactgac agagggaacg    180

gatgctcttt agtagcacat gcccaggatc gtgtgtgtgg ggcttgcgct gtgctgagaa    240

gctgaatacc ggtccatatg ctccttattt actgcaatgt tctttgcatg ttactgtgca    300

ctccggacta acgtgaagaa gtatcgatat caagatgagg acgctccaca tgatcattcc    360

ttacctcgac taacccacga agtaagaggc ccagaactcg tgcatgtatc agaaaagaac    420

ctctctcaaa tagaaaatgt ccatggatat gtcctgcagt ctcatatttc tcctctgaag    480

gccagtcctg ctcctataat tgtcaacaca gatactttgg acacaattcc ttatgtcaat    540

gggacagaaa ttgaatatga atttgaagaa attacactgg agagggggaa ttctggcctg    600

ggattcagta ttgctggggg gacagataat ccccacattg gagatgaccc tggcatattt    660

attacgaaga ttataccagg aggtgctgca gcagaggatg gcagactcag ggtcaatgat    720

tgtatcttgc gggtgaatga ggttgatgtg tcagaggttt cccacagtaa agcggtggaa    780

gccctgaagg aagcagggtc tatcgctcgg ctgtatgtgc gtagaagacg acctattttg    840

gagaccgttg tggaaatcaa actgttcaaa ggccctaaag gtttaggctt cagtattgca    900

ggaggtgtgg ggaaccaaca cattcctgga gacaacagca tttatgtaac taaaattata    960

gatggaggag ctgcacaaaa agatggaagg ttgcaagtag gagatagact actaatggta   1020

aacaactaca gtttagaaga agtaacacac gaagaggcag tagcaatatt aaagaacaca   1080

tcagaggtag tttatttaaa agttggcaac cccactacca tttatatgac tgatccttat   1140

ggtccacctg atattactca ctcttattct ccaccaatgg aaaaccatct actctctggc   1200

aacaatggca ctttagaata taaaacctcc ctgccaccca tctctccagg gaggtactca   1260

ccaattccaa agcacatgct tgttgacgac gactacacca ggcctccgga acctgtttac   1320

agcactgtga acaaactatg tgataagcct gcttctccca ggcactattc ccctgttgag   1380

tgtgacaaaa gcttcctcct ctcagctccc tattcccact accacctagg cctgctacct   1440

gactctgaga tgaccagtca ttcccaacat agcaccgcaa ctcgtcagcc ttcaatgact   1500

ctccaacggg ccgtctccct ggaaggagag cctcgcaagg tagtcctgca caaaggctcc   1560

actggcctgg gcttcaacat tgtcggtggg gaagatggag aaggtatttt tgtgtccttc   1620

attctggctg gtggaccagc agacctaagt ggggagctcc agagaggaga ccagatccta   1680

tcggtgaatg gcattgacct ccgtggtgca tcccacgagc aggcagctgc tgcactaaag   1740

ggggctggac agacagtgac gattatagca caatatcaac ctgaagatta cgctcgattt   1800

gaggccaaaa tccatgacct acgagagcag atgatgaacc acagcatgag ctccgggtcc   1860

ggatccctgc gaaccaatca gaaacgctcc ctctacgtca gagccatgtt cgactacgac   1920

aagagcaagg acagtgggct gccaagtcaa ggacttagtt ttaaatatgg agatattctc   1980

cacgttatca atgcctctga tgatgagtgg tggcaagcca ggagagtcat gctggaggga   2040

gacagtgagg agatgggggt catccccagc aaaaggaggg tggaaagaaa ggaacgtgcc   2100

cgattgaaga cagtgaagtt taatgccaaa cctggagtga ttgattcgaa agggtcattc   2160

aatgacaagc gtaaaaagag cttcatcttt tcacgaaaat tcccattcta caagaacaag   2220

gagcagagtg agcaggaaac cagtgatcct gaacgtggac aagaagacct cattctttcc   2280

tatgagcctg ttacaaggca ggaaataaac tacacccggc cggtgattat cctggggccc   2340

atgaaggatc ggatcaatga cgacttgata tctgaattcc ctgataaatt tggctcctgt   2400

gtgcctcata ctacgaggcc aaagcgagac tacgaggtgg atggcagaga ctatcacttt   2460

gtcatttcca gagaacaaat ggagaaagat atccaagagc acaagtttat agaagccggc   2520

cagtacaatg acaatttata tggaaccagt gtgcagtctg tgagatttgt agcagaaaga   2580

ggcaaacact gtatacttga tgtatcagga aatgctatca agcggttaca agttgcccag   2640

ctctatccca ttgccatctt cataaaaccc aggtctctgg aatctcttat ggagatgaat   2700

aagcgtctaa cagaggaaca agccaagaaa acctatgatc gagcaattaa gctagaacaa   2760

gaatttggag aatattttac agctattgtc caaggagata ctttagaaga tatatataac   2820

caatgcaagc ttgttattga agagcaatct gggcctttca tctggattcc ctcaaaggaa   2880

aagttataaa ttagctactg cgcctctgac aacgacagaa gagcatttag aagaacaaaa   2940

tatatataac atactacttg gaggctttta tgtttttgtt gcatttatgt ttttgcagtc   3000

aatgtgaatt cttacgaatg tacaacacaa actgtatgaa gccatgaagg aaacagaggg   3060

gccaaagggt g                                                        3071


<210>  486
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  486

Met Phe Phe Ala Cys Tyr Cys Ala Leu Arg Thr Asn Val Lys Lys Tyr 
1               5                   10                  15      


Arg Tyr Gln Asp Glu Asp Ala Pro His Asp His Ser Leu Pro Arg Leu 
            20                  25                  30          


Thr His Glu Val Arg Gly Pro Glu Leu Val His Val Ser Glu Lys Asn 
        35                  40                  45              


Leu Ser Gln Ile Glu Asn Val His Gly Tyr Val Leu Gln Ser His Ile 
    50                  55                  60                  


Ser Pro Leu Lys Ala Ser Pro Ala Pro Ile Ile Val Asn Thr Asp Thr 
65                  70                  75                  80  


Leu Asp Thr Ile Pro Tyr Val Asn Gly Thr Glu Ile Glu Tyr Glu Phe 
                85                  90                  95      


Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile 
            100                 105                 110         


Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Gly Ile Phe 
        115                 120                 125             


Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Glu Asp Gly Arg Leu 
    130                 135                 140                 


Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Ser Glu 
145                 150                 155                 160 


Val Ser His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile 
                165                 170                 175     


Ala Arg Leu Tyr Val Arg Arg Arg Arg Pro Ile Leu Glu Thr Val Val 
            180                 185                 190         


Glu Ile Lys Leu Phe Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala 
        195                 200                 205             


Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val 
    210                 215                 220                 


Thr Lys Ile Ile Asp Gly Gly Ala Ala Gln Lys Asp Gly Arg Leu Gln 
225                 230                 235                 240 


Val Gly Asp Arg Leu Leu Met Val Asn Asn Tyr Ser Leu Glu Glu Val 
                245                 250                 255     


Thr His Glu Glu Ala Val Ala Ile Leu Lys Asn Thr Ser Glu Val Val 
            260                 265                 270         


Tyr Leu Lys Val Gly Asn Pro Thr Thr Ile Tyr Met Thr Asp Pro Tyr 
        275                 280                 285             


Gly Pro Pro Asp Ile Thr His Ser Tyr Ser Pro Pro Met Glu Asn His 
    290                 295                 300                 


Leu Leu Ser Gly Asn Asn Gly Thr Leu Glu Tyr Lys Thr Ser Leu Pro 
305                 310                 315                 320 


Pro Ile Ser Pro Gly Arg Tyr Ser Pro Ile Pro Lys His Met Leu Val 
                325                 330                 335     


Asp Asp Asp Tyr Thr Arg Pro Pro Glu Pro Val Tyr Ser Thr Val Asn 
            340                 345                 350         


Lys Leu Cys Asp Lys Pro Ala Ser Pro Arg His Tyr Ser Pro Val Glu 
        355                 360                 365             


Cys Asp Lys Ser Phe Leu Leu Ser Ala Pro Tyr Ser His Tyr His Leu 
    370                 375                 380                 


Gly Leu Leu Pro Asp Ser Glu Met Thr Ser His Ser Gln His Ser Thr 
385                 390                 395                 400 


Ala Thr Arg Gln Pro Ser Met Thr Leu Gln Arg Ala Val Ser Leu Glu 
                405                 410                 415     


Gly Glu Pro Arg Lys Val Val Leu His Lys Gly Ser Thr Gly Leu Gly 
            420                 425                 430         


Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Val Ser Phe 
        435                 440                 445             


Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Gln Arg Gly 
    450                 455                 460                 


Asp Gln Ile Leu Ser Val Asn Gly Ile Asp Leu Arg Gly Ala Ser His 
465                 470                 475                 480 


Glu Gln Ala Ala Ala Ala Leu Lys Gly Ala Gly Gln Thr Val Thr Ile 
                485                 490                 495     


Ile Ala Gln Tyr Gln Pro Glu Asp Tyr Ala Arg Phe Glu Ala Lys Ile 
            500                 505                 510         


His Asp Leu Arg Glu Gln Met Met Asn His Ser Met Ser Ser Gly Ser 
        515                 520                 525             


Gly Ser Leu Arg Thr Asn Gln Lys Arg Ser Leu Tyr Val Arg Ala Met 
    530                 535                 540                 


Phe Asp Tyr Asp Lys Ser Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu 
545                 550                 555                 560 


Ser Phe Lys Tyr Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp 
                565                 570                 575     


Glu Trp Trp Gln Ala Arg Arg Val Met Leu Glu Gly Asp Ser Glu Glu 
            580                 585                 590         


Met Gly Val Ile Pro Ser Lys Arg Arg Val Glu Arg Lys Glu Arg Ala 
        595                 600                 605             


Arg Leu Lys Thr Val Lys Phe Asn Ala Lys Pro Gly Val Ile Asp Ser 
    610                 615                 620                 


Lys Gly Ser Phe Asn Asp Lys Arg Lys Lys Ser Phe Ile Phe Ser Arg 
625                 630                 635                 640 


Lys Phe Pro Phe Tyr Lys Asn Lys Glu Gln Ser Glu Gln Glu Thr Ser 
                645                 650                 655     


Asp Pro Glu Arg Gly Gln Glu Asp Leu Ile Leu Ser Tyr Glu Pro Val 
            660                 665                 670         


Thr Arg Gln Glu Ile Asn Tyr Thr Arg Pro Val Ile Ile Leu Gly Pro 
        675                 680                 685             


Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser Glu Phe Pro Asp Lys 
    690                 695                 700                 


Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Asp Tyr Glu 
705                 710                 715                 720 


Val Asp Gly Arg Asp Tyr His Phe Val Ile Ser Arg Glu Gln Met Glu 
                725                 730                 735     


Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Asp 
            740                 745                 750         


Asn Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Phe Val Ala Glu Arg 
        755                 760                 765             


Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu 
    770                 775                 780                 


Gln Val Ala Gln Leu Tyr Pro Ile Ala Ile Phe Ile Lys Pro Arg Ser 
785                 790                 795                 800 


Leu Glu Ser Leu Met Glu Met Asn Lys Arg Leu Thr Glu Glu Gln Ala 
                805                 810                 815     


Lys Lys Thr Tyr Asp Arg Ala Ile Lys Leu Glu Gln Glu Phe Gly Glu 
            820                 825                 830         


Tyr Phe Thr Ala Ile Val Gln Gly Asp Thr Leu Glu Asp Ile Tyr Asn 
        835                 840                 845             


Gln Cys Lys Leu Val Ile Glu Glu Gln Ser Gly Pro Phe Ile Trp Ile 
    850                 855                 860                 


Pro Ser Lys Glu Lys Leu 
865                 870 


<210>  487
<211>  2265
<212>  DNA
<213>  Homosapiens

<400>  487
acgcgggata cagggagggg ccatgtgcga accagggaga cctcatcttc caaccaagct     60

tgctgggctt gcatttaatc aatgcatggc cagagaacag gagcggaaca ttgcctagta    120

gaccctgagg ctttacaaca gtgctactga cccctatgag cctgatgctg gatgaccaac    180

cccctatgga ggcccagtat gcagaggagg gcccaggacc tgggatcttc agagcagagc    240

ctggagacca gcagcatccc atttctcagg cggtgtgctg gcgttccatg cgacgtggct    300

gtgcagtgct gggagccctg gggctgctgg ccggtgcagg tgttggctca tggctcctag    360

tgctgtatct gtgtcctgct gcctctcagc ccatttccgg gaccttgcag gatgaggaga    420

taactttgag ctgctcagag gccagcgctg aggaagctct gctccctgca ctccccaaaa    480

cagtatcttt cagaataaac agcgaagact tcttgctgga agcgcaagtg agggatcagc    540

cacgctggct cctggtctgc catgagggct ggagccccgc cctggggctg cagatctgct    600

ggagccttgg gcatctcaga ctcactcacc acaagggagt aaacctcact gacatcaaac    660

tcaacagttc ccaggagttt gctcagctct ctcctagact gggaggcttc ctggaggagg    720

cgtggcagcc caggaacaac tgcacttctg gtcaagttgt ttccctcaga tgctctgagt    780

gtggagcgag gcccctggct tcccggatag ttggtgggca gtctgtggct cctgggcgct    840

ggccgtggca ggccagcgtg gccctgggct tccggcacac gtgtgggggc tctgtgctag    900

cgccacgctg ggtggtgact gctgcacatt gtatgcacag tttcaggctg gcccgcctgt    960

ccagctggcg ggttcatgcg gggctggtca gccacagtgc cgtcaggccc caccaagggg   1020

ctctggtgga gaggattatc ccacaccccc tctacagtgc ccagaatcat gactacgacg   1080

tcgccctcct gaggctccag accgctctca acttctcaga cactgtgggc gctgtgtgcc   1140

tgccggccaa ggaacagcat tttccgaagg gctcgcggtg ctgggtgtct ggctggggcc   1200

acacccaccc tagccatact tacagctcgg atatgctcca ggacacggtg gtgcccttgt   1260

tcagcactca gctctgcaac agctcttgcg tgtacagcgg agccctcacc ccccgcatgc   1320

tttgcgctgg ctacctggac ggaagggctg atgcatgcca gggagatagc gggggccccc   1380

tagtgtgccc agatggggac acatggcgcc tagtgggggt ggtcagctgg gggcgtgcgt   1440

gcgcagagcc caatcaccca ggtgtctacg ccaaggtagc tgagtttctg gactggatcc   1500

atgacactgc tcaggactcc ctcctctgag tcctgctgtt tcctccagtc tcactgcaca   1560

ccactgcctc atgcttcctg gggcctccag cagctccact aatggaggag aggcagtagc   1620

ctccgacaca gaacgcatgg acctcctact actgtgtgtg aggaacagtc actacccact   1680

ggccagccac ccagccaaca ggtctctcct cttgggccct gatttcagag tcctctttct   1740

cactagagac tcaatgacag aagagaggct gggacttggt tgggcatgct gtggttgctg   1800

agggatgagg gggaggagag aggtaggagc tggagatgaa gagactgcta gaagcagcag   1860

gaagcctgcc cttctgccct ctcccctccc tgcccctgtg tgagtctttt agggagggtg   1920

actgggaggt gccccccgtc ccaccttttt cctgtgctct aggtgggcta agtgcctccc   1980

tagaggactc catggctgag aggctcctgg gcagatgggg tcaaggctgg gccagtccca   2040

gatgaagcct atgggagtca ggaccctctc cactctccct ctccactccc cttcctgttc   2100

tcacctggct gtggctggcc ctgtgtgggg tgggtacact ggaaaacaag aaggttggag   2160

ttggtctagg acattggttt taaatgacag ttctgtgaac tggtccaagg aggttctgtt   2220

attaaagtga tatatggtct tgaaaaaaaa aaaaaaaaaa aaaaa                   2265


<210>  488
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  488

Met Ser Leu Met Leu Asp Asp Gln Pro Pro Met Glu Ala Gln Tyr Ala 
1               5                   10                  15      


Glu Glu Gly Pro Gly Pro Gly Ile Phe Arg Ala Glu Pro Gly Asp Gln 
            20                  25                  30          


Gln His Pro Ile Ser Gln Ala Val Cys Trp Arg Ser Met Arg Arg Gly 
        35                  40                  45              


Cys Ala Val Leu Gly Ala Leu Gly Leu Leu Ala Gly Ala Gly Val Gly 
    50                  55                  60                  


Ser Trp Leu Leu Val Leu Tyr Leu Cys Pro Ala Ala Ser Gln Pro Ile 
65                  70                  75                  80  


Ser Gly Thr Leu Gln Asp Glu Glu Ile Thr Leu Ser Cys Ser Glu Ala 
                85                  90                  95      


Ser Ala Glu Glu Ala Leu Leu Pro Ala Leu Pro Lys Thr Val Ser Phe 
            100                 105                 110         


Arg Ile Asn Ser Glu Asp Phe Leu Leu Glu Ala Gln Val Arg Asp Gln 
        115                 120                 125             


Pro Arg Trp Leu Leu Val Cys His Glu Gly Trp Ser Pro Ala Leu Gly 
    130                 135                 140                 


Leu Gln Ile Cys Trp Ser Leu Gly His Leu Arg Leu Thr His His Lys 
145                 150                 155                 160 


Gly Val Asn Leu Thr Asp Ile Lys Leu Asn Ser Ser Gln Glu Phe Ala 
                165                 170                 175     


Gln Leu Ser Pro Arg Leu Gly Gly Phe Leu Glu Glu Ala Trp Gln Pro 
            180                 185                 190         


Arg Asn Asn Cys Thr Ser Gly Gln Val Val Ser Leu Arg Cys Ser Glu 
        195                 200                 205             


Cys Gly Ala Arg Pro Leu Ala Ser Arg Ile Val Gly Gly Gln Ser Val 
    210                 215                 220                 


Ala Pro Gly Arg Trp Pro Trp Gln Ala Ser Val Ala Leu Gly Phe Arg 
225                 230                 235                 240 


His Thr Cys Gly Gly Ser Val Leu Ala Pro Arg Trp Val Val Thr Ala 
                245                 250                 255     


Ala His Cys Met His Ser Phe Arg Leu Ala Arg Leu Ser Ser Trp Arg 
            260                 265                 270         


Val His Ala Gly Leu Val Ser His Ser Ala Val Arg Pro His Gln Gly 
        275                 280                 285             


Ala Leu Val Glu Arg Ile Ile Pro His Pro Leu Tyr Ser Ala Gln Asn 
    290                 295                 300                 


His Asp Tyr Asp Val Ala Leu Leu Arg Leu Gln Thr Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Asp Thr Val Gly Ala Val Cys Leu Pro Ala Lys Glu Gln His Phe 
                325                 330                 335     


Pro Lys Gly Ser Arg Cys Trp Val Ser Gly Trp Gly His Thr His Pro 
            340                 345                 350         


Ser His Thr Tyr Ser Ser Asp Met Leu Gln Asp Thr Val Val Pro Leu 
        355                 360                 365             


Phe Ser Thr Gln Leu Cys Asn Ser Ser Cys Val Tyr Ser Gly Ala Leu 
    370                 375                 380                 


Thr Pro Arg Met Leu Cys Ala Gly Tyr Leu Asp Gly Arg Ala Asp Ala 
385                 390                 395                 400 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Pro Asp Gly Asp Thr 
                405                 410                 415     


Trp Arg Leu Val Gly Val Val Ser Trp Gly Arg Ala Cys Ala Glu Pro 
            420                 425                 430         


Asn His Pro Gly Val Tyr Ala Lys Val Ala Glu Phe Leu Asp Trp Ile 
        435                 440                 445             


His Asp Thr Ala Gln Asp Ser Leu Leu 
    450                 455         


<210>  489
<211>  2900
<212>  DNA
<213>  Homosapiens

<400>  489
gagagtgacc cagtcagcgt tggttcccgt cttggccatg gcctcgttcg tgacagaagt     60

tttggcacac tccgggaggc tggaaaagga ggatctgggg acccggatca gccgcctgac    120

ccggcgggtg gaggagatca agggtgaggt gtgcaatatg attagcaaga agtacagtga    180

attcctgcct agcatgcaga gcgcgcaggg cctgattacc caggtggata agctatctga    240

agacattgac ctgctgaaat ccaggataga gagtgaggtc cgccgggatc ttcacgtatc    300

aaccggtgaa tttacagact taaagcagca gttggaaaga gactcagttg tcctaagttt    360

gcttaaacag ttgcaggagt tttccactgc tattgaagaa tataattgtg cattaacaga    420

gaagaagtat gtcactggtg ctcagcgtct ggaagaggca cagaaatgct tgaagttatt    480

aaaatccaga aaatgctttg atttaaaaat attgaaatct ctcagcatgg agctcacaat    540

acagaaacag aacatacttt atcaccttgg agaagagtgg cagaagctga ttgtatggaa    600

gttcccacca tcaaaagata ccagcagttt ggaatcttac ctacaaactg aacttcattt    660

atacactgaa caatcgcaca aagaggagaa gacccctatg ccacccatca gttctgtcct    720

cttggcattt tctgttcttg gagaactaca cagcaagctt aaatcatttg gtcagatgct    780

gctgaagtat atccttaggc cgctggcatc ttgcccatcc cttcatgctg tgatagaaag    840

ccagcctaac atagttatta ttcgttttga atctataatg actaacttgg aatatccatc    900

accatctgaa gtttttacaa agatcagact ggtactagaa gtgctccaga aacagcttct    960

agatttgcca cttgacactg acctggaaaa tgaaaaaaca tctactgtcc cattggctga   1020

gatgcttgga gacatgatct gggaggactt gtctgagtgc ctcatcaaaa actgtttggt   1080

ttattcgatt ccaacaaata gcagcaaatt acagcaatat gaagagatca tacagtccac   1140

tgaagaattt gaaaatgccc taaaggaaat gagattttta aaaggagata ctacagattt   1200

gctgaaatac gctcgtaaca tcaattctca ttttgcaaac aaaaagtgcc aggatgtgat   1260

tgtggcagcc agaaatctaa tgacctcaga aattcataac actgtgaaga ttattcctga   1320

ttctaagata aatgtgccag agttacccac tcctgatgag gataacaaac tggaagtaca   1380

gaaagtatcc aatactcagt accacgaagt gatgaattta gagcctgaaa atacattgga   1440

ccaacattcc ttttccttgc ccacatgccg tatcagtgag tctgtgaaga aattaatgga   1500

actcgcctat cagactttac tagaggcaac aaccagtagt gatcaatgtg ctgttcaact   1560

tttctactca gtgaggaata tcttccattt gttccatgat gttgtaccaa catatcacaa   1620

ggagaacctt caaaaacttc cccagttggc tgctattcat cacaacaact gtatgtacat   1680

tgctcaccac ttgctgaccc tcgggcatca gttcagattg cgtcttgccc ccattctttg   1740

tgatggcact gctacttttg tggatcttgt acctggcttc aggagacttg ggacagaatg   1800

ctttttggcc caaatgcggg cacagaaagg tgaacttctg gaaagattat caagtgctag   1860

gaacttttca aatatggacg atgaagagaa ttattctgca gcaagtaaag cagtccggca   1920

ggtactgcac caactaaaga gacttggaat tgtgtggcag gatgtcctgc cagtgaatat   1980

atattgcaag gctatgggga ctttactcaa tacagcaatt tctgaggtca ttggcaaaat   2040

tactgcccta gaggacatat ctactgaaga tggtgatagg ttatattcct tatgcaaaac   2100

agtgatggat gaaggacccc aagtatttgc acctttatct gaagaaagca agaacaagaa   2160

atatcaagaa gaggttccag tctatgtgcc aaaatggatg ccattcaagg aattgatgat   2220

gatgctacaa gccagcttgc aagaaattgg ggatcggtgg gcagatggaa aaggacccct   2280

ggcagctgcg ttctcttcca gtgaagtaaa agctttaatt cgtgccttgt ttcagaacac   2340

agaaagaaga gcagctgccc ttgctaaaat taaatagctc catcttctta agaaagctat   2400

gtcttgaata tgtggattct tcccttggca taattactcc cttaaagact tctttgaatc   2460

gcccattggt tttggtgaac cagtacatct tggaagtttg actttacaga agaacgtctt   2520

acctcctggc ctgtacgagg ctttgtttaa gaactgttta ttaagataaa ttgtcaagta   2580

aagcacctca attcattgac tttctagcca tcttcctttg attagctaac aaactgtcag   2640

gcagcattat ttcatgctgc ttccagagcc ctctgggagc tatatacatt gtaaatgcag   2700

gccctagctt tggaacgagg aattgggaga ttccaggagt cagggtagag aatttctgag   2760

caaatcggag atattttagg ggtgtggagg aggggaaggg aggaatgggc caccatattt   2820

ggccttacag gaattaagga gacttcctgt aatatttctt tccaataaat attgcttttt   2880

acaaaaaaaa aaaaaaaaaa                                               2900


<210>  490
<211>  779
<212>  PRT
<213>  Homosapiens

<400>  490

Met Ala Ser Phe Val Thr Glu Val Leu Ala His Ser Gly Arg Leu Glu 
1               5                   10                  15      


Lys Glu Asp Leu Gly Thr Arg Ile Ser Arg Leu Thr Arg Arg Val Glu 
            20                  25                  30          


Glu Ile Lys Gly Glu Val Cys Asn Met Ile Ser Lys Lys Tyr Ser Glu 
        35                  40                  45              


Phe Leu Pro Ser Met Gln Ser Ala Gln Gly Leu Ile Thr Gln Val Asp 
    50                  55                  60                  


Lys Leu Ser Glu Asp Ile Asp Leu Leu Lys Ser Arg Ile Glu Ser Glu 
65                  70                  75                  80  


Val Arg Arg Asp Leu His Val Ser Thr Gly Glu Phe Thr Asp Leu Lys 
                85                  90                  95      


Gln Gln Leu Glu Arg Asp Ser Val Val Leu Ser Leu Leu Lys Gln Leu 
            100                 105                 110         


Gln Glu Phe Ser Thr Ala Ile Glu Glu Tyr Asn Cys Ala Leu Thr Glu 
        115                 120                 125             


Lys Lys Tyr Val Thr Gly Ala Gln Arg Leu Glu Glu Ala Gln Lys Cys 
    130                 135                 140                 


Leu Lys Leu Leu Lys Ser Arg Lys Cys Phe Asp Leu Lys Ile Leu Lys 
145                 150                 155                 160 


Ser Leu Ser Met Glu Leu Thr Ile Gln Lys Gln Asn Ile Leu Tyr His 
                165                 170                 175     


Leu Gly Glu Glu Trp Gln Lys Leu Ile Val Trp Lys Phe Pro Pro Ser 
            180                 185                 190         


Lys Asp Thr Ser Ser Leu Glu Ser Tyr Leu Gln Thr Glu Leu His Leu 
        195                 200                 205             


Tyr Thr Glu Gln Ser His Lys Glu Glu Lys Thr Pro Met Pro Pro Ile 
    210                 215                 220                 


Ser Ser Val Leu Leu Ala Phe Ser Val Leu Gly Glu Leu His Ser Lys 
225                 230                 235                 240 


Leu Lys Ser Phe Gly Gln Met Leu Leu Lys Tyr Ile Leu Arg Pro Leu 
                245                 250                 255     


Ala Ser Cys Pro Ser Leu His Ala Val Ile Glu Ser Gln Pro Asn Ile 
            260                 265                 270         


Val Ile Ile Arg Phe Glu Ser Ile Met Thr Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Pro Ser Glu Val Phe Thr Lys Ile Arg Leu Val Leu Glu Val Leu Gln 
    290                 295                 300                 


Lys Gln Leu Leu Asp Leu Pro Leu Asp Thr Asp Leu Glu Asn Glu Lys 
305                 310                 315                 320 


Thr Ser Thr Val Pro Leu Ala Glu Met Leu Gly Asp Met Ile Trp Glu 
                325                 330                 335     


Asp Leu Ser Glu Cys Leu Ile Lys Asn Cys Leu Val Tyr Ser Ile Pro 
            340                 345                 350         


Thr Asn Ser Ser Lys Leu Gln Gln Tyr Glu Glu Ile Ile Gln Ser Thr 
        355                 360                 365             


Glu Glu Phe Glu Asn Ala Leu Lys Glu Met Arg Phe Leu Lys Gly Asp 
    370                 375                 380                 


Thr Thr Asp Leu Leu Lys Tyr Ala Arg Asn Ile Asn Ser His Phe Ala 
385                 390                 395                 400 


Asn Lys Lys Cys Gln Asp Val Ile Val Ala Ala Arg Asn Leu Met Thr 
                405                 410                 415     


Ser Glu Ile His Asn Thr Val Lys Ile Ile Pro Asp Ser Lys Ile Asn 
            420                 425                 430         


Val Pro Glu Leu Pro Thr Pro Asp Glu Asp Asn Lys Leu Glu Val Gln 
        435                 440                 445             


Lys Val Ser Asn Thr Gln Tyr His Glu Val Met Asn Leu Glu Pro Glu 
    450                 455                 460                 


Asn Thr Leu Asp Gln His Ser Phe Ser Leu Pro Thr Cys Arg Ile Ser 
465                 470                 475                 480 


Glu Ser Val Lys Lys Leu Met Glu Leu Ala Tyr Gln Thr Leu Leu Glu 
                485                 490                 495     


Ala Thr Thr Ser Ser Asp Gln Cys Ala Val Gln Leu Phe Tyr Ser Val 
            500                 505                 510         


Arg Asn Ile Phe His Leu Phe His Asp Val Val Pro Thr Tyr His Lys 
        515                 520                 525             


Glu Asn Leu Gln Lys Leu Pro Gln Leu Ala Ala Ile His His Asn Asn 
    530                 535                 540                 


Cys Met Tyr Ile Ala His His Leu Leu Thr Leu Gly His Gln Phe Arg 
545                 550                 555                 560 


Leu Arg Leu Ala Pro Ile Leu Cys Asp Gly Thr Ala Thr Phe Val Asp 
                565                 570                 575     


Leu Val Pro Gly Phe Arg Arg Leu Gly Thr Glu Cys Phe Leu Ala Gln 
            580                 585                 590         


Met Arg Ala Gln Lys Gly Glu Leu Leu Glu Arg Leu Ser Ser Ala Arg 
        595                 600                 605             


Asn Phe Ser Asn Met Asp Asp Glu Glu Asn Tyr Ser Ala Ala Ser Lys 
    610                 615                 620                 


Ala Val Arg Gln Val Leu His Gln Leu Lys Arg Leu Gly Ile Val Trp 
625                 630                 635                 640 


Gln Asp Val Leu Pro Val Asn Ile Tyr Cys Lys Ala Met Gly Thr Leu 
                645                 650                 655     


Leu Asn Thr Ala Ile Ser Glu Val Ile Gly Lys Ile Thr Ala Leu Glu 
            660                 665                 670         


Asp Ile Ser Thr Glu Asp Gly Asp Arg Leu Tyr Ser Leu Cys Lys Thr 
        675                 680                 685             


Val Met Asp Glu Gly Pro Gln Val Phe Ala Pro Leu Ser Glu Glu Ser 
    690                 695                 700                 


Lys Asn Lys Lys Tyr Gln Glu Glu Val Pro Val Tyr Val Pro Lys Trp 
705                 710                 715                 720 


Met Pro Phe Lys Glu Leu Met Met Met Leu Gln Ala Ser Leu Gln Glu 
                725                 730                 735     


Ile Gly Asp Arg Trp Ala Asp Gly Lys Gly Pro Leu Ala Ala Ala Phe 
            740                 745                 750         


Ser Ser Ser Glu Val Lys Ala Leu Ile Arg Ala Leu Phe Gln Asn Thr 
        755                 760                 765             


Glu Arg Arg Ala Ala Ala Leu Ala Lys Ile Lys 
    770                 775                 


<210>  491
<211>  4642
<212>  DNA
<213>  Homosapiens

<400>  491
gagaccggtg acccgcggct gggcgcctcg gccatgactg cggagctgca gcaggacgac     60

gcggccggcg cggcagacgg ccacggctcg agctgccaaa tgctgttaaa tcaactgaga    120

gaaatcacag gcattcagga cccttccttt ctccatgaag ctctgaaggc cagtaatggt    180

gacattactc aggcagtcag ccttctcact gatgagagag ttaaggagcc cagtcaagac    240

actgttgcta cagaaccatc tgaagtagag gggagtgctg ccaacaagga agtattagca    300

aaagttatag accttactca tgataacaaa gatgatcttc aggctgccat tgctttgagt    360

ctactggagt ctcccaaaat tcaagctgat ggaagagatc ttaacaggat gcatgaagca    420

acctctgcag aaactaaacg ctcaaagaga aaacgctgtg aagtctgggg agaaaacccc    480

aatcccaatg actggaggag agttgatggt tggccagttg ggctgaaaaa tgttggcaat    540

acatgttggt ttagtgctgt tattcagtct ctctttcaat tgcctgaatt tcgaagactt    600

gttctcagtt atagtctgcc acaaaatgta cttgaaaatt gtcgaagtca tacagaaaag    660

agaaatatca tgtttatgca agagcttcag tatttgtttg ctctaatgat gggatcaaat    720

agaaaatttg tagacccgtc tgcagccctg gatctattaa agggagcatt ccgatcatct    780

gaggaacagc agcaagatgt gagtgaattc acacacaagc tcctggattg gctagaggac    840

gcattccagc tagctgttaa tgttaacagt cccaggaaca aatctgaaaa tccaatggtg    900

cagctgttct atggtacttt cctgactgaa ggggttcgtg aaggaaaacc cttttgtaac    960

aatgagacct tcggccagta tcctcttcag gtaaacggtt atcgcaactt agacgagtgt   1020

ttggaagggg ccatggtgga gggtgatgtt gagcttcttc cctccgatca ctcggtgaag   1080

tatggacaag agcgttggtt tacaaagcta cctccagtgt tgacctttga actctcaaga   1140

tttgagttta atcagtccct tgggcagcca gagaaaattc acaataagct ggaatttcct   1200

cagattattt atatggacag gtacatgtac aggagcaagg agcttattcg aaataagaga   1260

gagtgtattc gaaagttgaa ggaggaaata aaaattctgc agcaaaaatt ggaaaggtat   1320

gtgaaatatg gctcaggccc agctcggttc ccgctcccgg acatgctgaa atatgttatt   1380

gaatttgcta gtacaaaacc tgcctcagaa agctgtccac ctgaaagtga cacacatatg   1440

acattaccac tttcttcagt gcactgctcg gtttctgacc agacatccaa ggaaagtaca   1500

agtacagaaa gctcttctca ggatgttgaa agtacctttt cttctcctga agattcttta   1560

cccaagtcta aaccactgac atcttctcgg tcttccatgg aaatgccttc acagccagct   1620

ccacgaacag tcacagatga ggagataaat tttgttaaga cctgtcttca gagatggagg   1680

agtgagattg aacaagatat acaagattta aagacttgta ttgcaagtac tactcagact   1740

attgaacaga tgtactgcga tcctctcctt cgtcaggtgc cttatcgctt gcatgcagtt   1800

cttgttcatg aaggacaagc aaatgctgga cactattggg cctatatcta taatcaaccc   1860

cgacagagct ggctcaagta caatgacatc tctgttactg aatcttcctg ggaagaagtt   1920

gaaagagatt cctatggagg cctgagaaat gttagtgctt actgtctgat gtacattaat   1980

gacaaactac cctacttcaa tgcagaggca gccccaactg aatcagatca aatgtcagaa   2040

gtggaagccc tatctgtgga actcaagcat tacattcagg aggataactg gcggtttgag   2100

caggaagtag aggagtggga agaagagcag tcttgcaaaa tccctcaaat ggagtcctcc   2160

accaactcct catcacagga ctactctaca tcacaagagc cttcagtagc ctcttctcat   2220

ggggttcgct gcttgtcgtc tgagcatgct gtgattgtaa aggagcaaac tgcccaggct   2280

attgcaaaca cagcccgtgc ctatgagaag agcggtgtag aagcggcact gagtgaggtg   2340

atgctgagcc ctgccatgca aggggtcatc ctggccatag ctaaagcccg tcagaccttt   2400

gaccgagatg ggtctgaagc agggctgatt aaggcattcc atgaagaata ctccaggctc   2460

tatcagcttg ccaaagagac ccccacctct cacagtgatc ctcgacttca gcatgtcctt   2520

gtctactttt tccaaaatga agcacccaaa agggtagtag aacgaaccct tctggaacag   2580

tttgcagata aaaatcttag ctatgatgaa agatcaatca gcattatgaa ggtggctcaa   2640

gcgaaactga aggaaattgg tccagatgac atgaatatgg aagagtacaa gaagtggcat   2700

gaagattata gtttgttccg aaaagtgtct gtgtatctcc taacaggcct agaactctat   2760

caaaaaggaa agtaccaaga ggcactttcc tacctggtat atgcctacca gagcaatgct   2820

gccctgctga tgaaggggcc ccgccggggg gtcaaagaat ccgtgattgc tttataccga   2880

agaaaatgcc ttctggagct gaatgccaaa gcagcttctc tttttgaaac aaatgatgat   2940

cactccgtaa ctgagggcat taatgtgatg aatgaactga tcatcccctg cattcacctt   3000

atcattaata atgacatttc caaggatgat ctggatgcca ttgaggtcat gagaaaccat   3060

tggtgctctt accttgggca agatattgca gaaaatctgc agctgtgcct aggggagttt   3120

ctacccagac ttctagatcc ttctgcagaa atcatcgtct tgaaagagcc tccaactatt   3180

cgacccaatt ctccctatga cctatgtagc cgatttgcag ctgtcatgga gtcaattcag   3240

ggagtttcaa ctgtgacagt gaaataagct cccacatgtt caaggcccat tctggttcct   3300

ggctgcctgc ctcttgcaca gaagttcgtt gtcatagtgc tcaccttggg aaaaggatta   3360

ggtgggcaca taagattccg atcagacccc aaccatgctg catgtgtaaa gaaggattga   3420

aaataaaatt gcacttttta ggtacaaaat cataaaagct gtttcactag aaaaggcaga   3480

aagcagtgta ttaaggtgtt gaattacgcc agaagacctg aaatgccttg tacctacaac   3540

aatgcttagg cttttctaag cctcttgcca cttttaaaat tatccttcag gcataaatat   3600

ttttgacagc agaatagaag aatgattcat gagaacctga accagatgaa cagctactag   3660

ttattttatc aaatacagat gacatttaaa aattcttaac tacaagagat tagaaatata   3720

aaccttgcct ggctcttgcc aggagataac aaaatgggtt gctgatgaac tgcacccttt   3780

tacatgtggg tagaatataa gctcacatgg cagtgagatg ttgaaaagtc aaaagagacc   3840

tgtctctctc ctttcttttc tatctttaaa ccagaaaacc tcatactcag tcctcagtga   3900

aagaaagtaa agtattaagg actttagaca gaagagcatt gtgtaacttg actgaagatc   3960

atccattaat agttattagg catttaggta aaattttcta atacctaaaa attgtcaaaa   4020

acagtcaata gggctactgc tggcccaaag accatttagg tccacctcct cttttttgct   4080

cttttttttt ttctgtgaca gtttcactgt gtcgcccagg ctggcgttca gtggtgcaat   4140

ctcagctcac tgcaaactct gtctcctggg ctcaagtgat tctcgtgcct cagcctcccg   4200

aatagctgga attacgggca tgcaccacca cacctggcta atttttgtat ttttaataga   4260

gatggggttt caccatattg gccaggctga tctctaactc ctggcctcaa gtgatctatc   4320

tgcctccctc agcctcccaa agtctgggat tgcagacaag tcatcgtacc cggccttctt   4380

ttttgccctt aaaagtaagg gatgtgggtt tgtacaaaaa aaaaaaaaaa aaaaaaaaaa   4440

ccagcataca tatgcaaaac tatatatata tgtatatgta gagaaaaata cttcccattg   4500

atcattttta aaaggcttct gattggatat tgtgttttaa ccaaatttta aagattaatg   4560

gaatcatgaa agggaaaaaa attgatacaa ctatgcagat tttataaatg tgcaataaaa   4620

gtatttgttt taaaaaaaaa aa                                            4642


<210>  492
<211>  1077
<212>  PRT
<213>  Homosapiens

<400>  492

Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val His 
            580                 585                 590         


Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn Gln 
        595                 600                 605             


Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu Ser 
    610                 615                 620                 


Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn Val 
625                 630                 635                 640 


Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe Asn 
                645                 650                 655     


Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu Ala 
            660                 665                 670         


Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg Phe 
        675                 680                 685             


Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile Pro 
    690                 695                 700                 


Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr Ser 
705                 710                 715                 720 


Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser Ser 
                725                 730                 735     


Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala Asn 
            740                 745                 750         


Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser Glu 
        755                 760                 765             


Val Met Leu Ser Pro Ala Met Gln Gly Val Ile Leu Ala Ile Ala Lys 
    770                 775                 780                 


Ala Arg Gln Thr Phe Asp Arg Asp Gly Ser Glu Ala Gly Leu Ile Lys 
785                 790                 795                 800 


Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu Thr 
                805                 810                 815     


Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr Phe 
            820                 825                 830         


Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu Glu 
        835                 840                 845             


Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser Ile 
    850                 855                 860                 


Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp Met 
865                 870                 875                 880 


Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe Arg 
                885                 890                 895     


Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys Gly 
            900                 905                 910         


Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser Asn 
        915                 920                 925             


Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser Val 
    930                 935                 940                 


Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys Ala 
945                 950                 955                 960 


Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly Ile 
                965                 970                 975     


Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile Asn 
            980                 985                 990         


Asn Asp Ile Ser Lys Asp Asp Leu  Asp Ala Ile Glu Val  Met Arg Asn 
        995                 1000                 1005             


His Trp  Cys Ser Tyr Leu Gly  Gln Asp Ile Ala Glu  Asn Leu Gln 
    1010                 1015                 1020             


Leu Cys  Leu Gly Glu Phe Leu  Pro Arg Leu Leu Asp  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ile  Ile Val Leu Lys Glu  Pro Pro Thr Ile Arg  Pro Asn Ser 
    1040                 1045                 1050             


Pro Tyr  Asp Leu Cys Ser Arg  Phe Ala Ala Val Met  Glu Ser Ile 
    1055                 1060                 1065             


Gln Gly  Val Ser Thr Val Thr  Val Lys 
    1070                 1075         


<210>  493
<211>  1847
<212>  DNA
<213>  Homosapiens

<400>  493
gagaaattga gcggcattcc atctggtagg caagtttgca tttctccttt ttgggatctg     60

cccaggaatg ttgtcaagtg taatggctcc cctgtgggcc tgcatcctgg tggctgcagg    120

aattctagcc acagatacac atcatcccca ggattctgct ctgtatcatc tcagcaagca    180

gctattacag aaatatcata aagaagtgag acctgtttac aactggacca aggccaccac    240

agtctacctg gacctgttcg tccatgctat attggatgtg gatgcagaga atcaaatatt    300

aaagacaagt gtatggtacc aagaggtctg gaatgatgaa tttttatcct ggaactccag    360

catgtttgat gagattagag agatctccct acctctaagt gccatctggg cccccgatat    420

catcatcaat gagtttgtgg acattgaaag ataccctgac cttccctatg tttatgtgaa    480

ctcatctggg accattgaga actataagcc catccaggtg gtctctgcgt gcagtttaga    540

gacatatgct tttccatttg atgtccagaa ttgcagcctg accttcaaga gcattctgca    600

tacagtggaa gacgtagacc tggcctttct gaggagccca gaagacattc agcatgacaa    660

aaaggcgttt ttgaatgaca gtgagtggga acttctatct gtgtcctcca catacagcat    720

cctgcagagc agcgctggag gatttgcaca gattcagttt aatgtggtga tgcgcaggca    780

ccccctggtc tatgtcgtga gtctgctgat tcctagcatc tttctcatgc tggtggacct    840

ggggagcttc tacctgccac ccaactgccg agccaggatt gtgttcaaga ccagtgtgct    900

ggtgggctac accgtcttca gggtcaacat gtccaaccag gtgccacgga gtgtagggag    960

cacccctctg attgggcact tcttcaccat ctgcatggcc ttcttggttc tcagcttagc   1020

taagtccatc gtgttggtca aattcctcca tgatgagcag cgtggtggac aggagcagcc   1080

cttcttgtgc cttcgagggg acaccgatgc tgacaggcct agagtggaac ccagggccca   1140

acgtgctgtg gtaacagagt cctcgctgta tggagagcac ctggcccagc caggaaccct   1200

gaaggaagtc tggtcgcagc ttcaatctat cagcaactac ctccaaactc aggaccagac   1260

agaccaacag gaggcagagt ggctggtcct cctgtcccgc tttgaccgac tgctcttcca   1320

aagctacctt ttcatgctgg ggatctacac catcactctg tgctccctct gggcactgtg   1380

gggcggcgtg tgaagactga agtgttcttc agtaattgtg ctggcactta ggagagagag   1440

gagggggaat aatagtgggt taaaaagctt tctgggtcgg gtgtggtggt tcttgcctat   1500

agtcccagtg ctttgggagg ccatagcagg aggattgctt gagcccagga gttcgagacc   1560

agccagagca acatagtgag accacatctc taccagtaaa taaataaata aataaataaa   1620

taaataaata aataaatagc tgggcatagt ggctcatgcc tgtactctca gctacttggg   1680

aggttgaggt gggaggattg cttgagccca ggatttcaag gctgcagtga gccatgattg   1740

caccactgca ccccagcctg ggtgacagag caagaccctg tctcaaaaaa aataaaataa   1800

aaggctttct gccttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 1847


<210>  494
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  494

Met Leu Ser Ser Val Met Ala Pro Leu Trp Ala Cys Ile Leu Val Ala 
1               5                   10                  15      


Ala Gly Ile Leu Ala Thr Asp Thr His His Pro Gln Asp Ser Ala Leu 
            20                  25                  30          


Tyr His Leu Ser Lys Gln Leu Leu Gln Lys Tyr His Lys Glu Val Arg 
        35                  40                  45              


Pro Val Tyr Asn Trp Thr Lys Ala Thr Thr Val Tyr Leu Asp Leu Phe 
    50                  55                  60                  


Val His Ala Ile Leu Asp Val Asp Ala Glu Asn Gln Ile Leu Lys Thr 
65                  70                  75                  80  


Ser Val Trp Tyr Gln Glu Val Trp Asn Asp Glu Phe Leu Ser Trp Asn 
                85                  90                  95      


Ser Ser Met Phe Asp Glu Ile Arg Glu Ile Ser Leu Pro Leu Ser Ala 
            100                 105                 110         


Ile Trp Ala Pro Asp Ile Ile Ile Asn Glu Phe Val Asp Ile Glu Arg 
        115                 120                 125             


Tyr Pro Asp Leu Pro Tyr Val Tyr Val Asn Ser Ser Gly Thr Ile Glu 
    130                 135                 140                 


Asn Tyr Lys Pro Ile Gln Val Val Ser Ala Cys Ser Leu Glu Thr Tyr 
145                 150                 155                 160 


Ala Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Lys Ser Ile 
                165                 170                 175     


Leu His Thr Val Glu Asp Val Asp Leu Ala Phe Leu Arg Ser Pro Glu 
            180                 185                 190         


Asp Ile Gln His Asp Lys Lys Ala Phe Leu Asn Asp Ser Glu Trp Glu 
        195                 200                 205             


Leu Leu Ser Val Ser Ser Thr Tyr Ser Ile Leu Gln Ser Ser Ala Gly 
    210                 215                 220                 


Gly Phe Ala Gln Ile Gln Phe Asn Val Val Met Arg Arg His Pro Leu 
225                 230                 235                 240 


Val Tyr Val Val Ser Leu Leu Ile Pro Ser Ile Phe Leu Met Leu Val 
                245                 250                 255     


Asp Leu Gly Ser Phe Tyr Leu Pro Pro Asn Cys Arg Ala Arg Ile Val 
            260                 265                 270         


Phe Lys Thr Ser Val Leu Val Gly Tyr Thr Val Phe Arg Val Asn Met 
        275                 280                 285             


Ser Asn Gln Val Pro Arg Ser Val Gly Ser Thr Pro Leu Ile Gly His 
    290                 295                 300                 


Phe Phe Thr Ile Cys Met Ala Phe Leu Val Leu Ser Leu Ala Lys Ser 
305                 310                 315                 320 


Ile Val Leu Val Lys Phe Leu His Asp Glu Gln Arg Gly Gly Gln Glu 
                325                 330                 335     


Gln Pro Phe Leu Cys Leu Arg Gly Asp Thr Asp Ala Asp Arg Pro Arg 
            340                 345                 350         


Val Glu Pro Arg Ala Gln Arg Ala Val Val Thr Glu Ser Ser Leu Tyr 
        355                 360                 365             


Gly Glu His Leu Ala Gln Pro Gly Thr Leu Lys Glu Val Trp Ser Gln 
    370                 375                 380                 


Leu Gln Ser Ile Ser Asn Tyr Leu Gln Thr Gln Asp Gln Thr Asp Gln 
385                 390                 395                 400 


Gln Glu Ala Glu Trp Leu Val Leu Leu Ser Arg Phe Asp Arg Leu Leu 
                405                 410                 415     


Phe Gln Ser Tyr Leu Phe Met Leu Gly Ile Tyr Thr Ile Thr Leu Cys 
            420                 425                 430         


Ser Leu Trp Ala Leu Trp Gly Gly Val 
        435                 440     


<210>  495
<211>  2147
<212>  DNA
<213>  Homosapiens

<400>  495
gcagcctcag aaggtgtgag cagtggccac gagaggcagg ctggctggga catgaggttg     60

gcagagggca ggcaagctgg cccttggtgg gcctcgtcct gagcactcgg aggcactcct    120

atgcttggaa agctcgctat gctgctgtgg gtccagcagg cgctgctcgc cttgctcctc    180

cccacactcc tggcacaggg agaagccagg aggagccgaa acaccaccag gcccgctctg    240

ctgaggctgt cggattacct tttgaccaac tacaggaagg gtgtgcgccc cgtgagggac    300

tggaggaagc caaccaccgt atccattgac gtcattgtct atgccatcct caacgtggat    360

gagaagaatc aggtgctgac cacctacatc tggtaccggc agtactggac tgatgagttt    420

ctccagtgga accctgagga ctttgacaac atcaccaagt tgtccatccc cacggacagc    480

atctgggtcc cggacattct catcaatgag ttcgtggatg tggggaagtc tccaaatatc    540

ccgtacgtgt atattcggca tcaaggcgaa gttcagaact acaagcccct tcaggtggtg    600

actgcctgta gcctcgacat ctacaacttc cccttcgatg tccagaactg ctcgctgacc    660

ttcaccagtt ggctgcacac catccaggac atcaacatct ctttgtggcg cttgccagaa    720

aaggtgaaat ccgacaggag tgtcttcatg aaccagggag agtgggagtt gctgggggtg    780

ctgccctact ttcgggagtt cagcatggaa agcagtaact actatgcaga aatgaagttc    840

tatgtggtca tccgccggcg gcccctcttc tatgtggtca gcctgctact gcccagcatc    900

ttcctcatgg tcatggacat cgtgggcttc tacctgcccc ccaacagtgg cgagagggtc    960

tctttcaaga ttacactcct cctgggctac tcggtcttcc tgatcatcgt ttctgacacg   1020

ctgccggcca ctgccatcgg cactcctctc attggtgtct actttgtggt gtgcatggct   1080

ctgctggtga taagtttggc cgagaccatc ttcattgtgc ggctggtgca caagcaagac   1140

ctgcagcagc ccgtgcctgc ttggctgcgt cacctggttc tggagagaat cgcctggcta   1200

ctttgcctga gggagcagtc aacttcccag aggcccccag ccacctccca agccaccaag   1260

actgatgact gctcagccat gggaaaccac tgcagccaca tgggaggacc ccaggacttc   1320

gagaagagcc cgagggacag atgtagccct cccccaccac ctcgggaggc ctcgctggcg   1380

gtgtgtgggc tgctgcagga gctgtcctcc atccggcaat tcctggaaaa gcgggatgag   1440

atccgagagg tggcccgaga ctggctgcgc gtgggctccg tgctggacaa gctgctattc   1500

cacatttacc tgctagcggt gctggcctac agcatcaccc tggttatgct ctggtccatc   1560

tggcagtacg cttgagtggg tacagcccag tggaggaggg ggtacagtcc tggttaggtg   1620

gggacagagg atttctgctt aggcccctca ggacccaggg aatgccaggg acattttcaa   1680

gacacagaca aagtcccgtg ccctgtttcc aatgccaatt catctcagca atcacaagcc   1740

aaggtctgaa cccttccacc aaaaactggg tgttcaaggc ccttacaccc ttgtcccacc   1800

cccagcagct caccatggct ttaaaacatg ctctcttaga tcaggagaaa ctcgggcact   1860

ccctaagtcc actctagttg tggacttttc cccattgacc ctcacctgaa taagggactt   1920

tggaattctg cttctctttc acaactttgc ttttaggttg aaggcaaaac caactctcta   1980

ctacacaggc ctgataactc tgtacgaggc ttctctaacc cctagtgtct tttttttctt   2040

cacctcactt gtggcagctt ccctgaacac tcatccccca tcagatgatg ggagtgggaa   2100

gaataaaatg cagtgaaacc ctaaaaaaaa aaaaaaaaaa aaaaaaa                 2147


<210>  496
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  496

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
            20                  25                  30          


Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
        35                  40                  45              


Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
    50                  55                  60                  


Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
65                  70                  75                  80  


Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                85                  90                  95      


Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
            100                 105                 110         


Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
        115                 120                 125             


Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
    130                 135                 140                 


Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
145                 150                 155                 160 


Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                165                 170                 175     


Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
            180                 185                 190         


Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
        195                 200                 205             


Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
    210                 215                 220                 


Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
225                 230                 235                 240 


Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                245                 250                 255     


Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
            260                 265                 270         


Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
        275                 280                 285             


Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
    290                 295                 300                 


Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
305                 310                 315                 320 


Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                325                 330                 335     


Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
            340                 345                 350         


Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
        355                 360                 365             


Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
    370                 375                 380                 


Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
385                 390                 395                 400 


Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                405                 410                 415     


Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
            420                 425                 430         


Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
        435                 440                 445             


Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
    450                 455                 460                 


Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
465                 470                 475             


<210>  497
<211>  2243
<212>  DNA
<213>  Homosapiens

<400>  497
gcagcctcag aaggtgtgag cagtggccac gagaggcagg ctggctggga catgaggttg     60

gcagagggca ggcaagctgg cccttggtgg gcctcgtcct gagcactcgg aggcactcct    120

atgcttggaa agctcgctat gctgctgtgg gtccagcagg cgctgctcgc cttgctcctc    180

cccacactcc tggcacaggg agaagccagg aggagccgaa acaccaccag gcccgctctg    240

ctgaggctgt cggattacct tttgaccaac tacaggaagg gtgtgcgccc cgtgagggac    300

tggaggaagc caaccaccgt atccattgac gtcattgtct atgccatcct caacgtggat    360

gagaagaatc aggtgctgac cacctacatc tggtaccggc agtactggac tgatgagttt    420

ctccagtgga accctgagga ctttgacaac atcaccaagt tgtccatccc cacggacagc    480

atctgggtcc cggacattct catcaatgag ttcgtggatg tggggaagtc tccaaatatc    540

ccgtacgtgt atattcggca tcaaggcgaa gttcagaact acaagcccct tcaggtggtg    600

actgcctgta gcctcgacat ctacaacttc cccttcgatg tccagaactg ctcgctgacc    660

ttcaccagtt ggctgcacac catccaggac atcaacatct ctttgtggcg cttgccagaa    720

aaggtgaaat ccgacaggag tgtcttcatg aaccagggag agtgggagtt gctgggggtg    780

ctgccctact ttcgggagtt cagcatggaa agcagtaact actatgcaga aatgaagttc    840

tatgtggtca tccgccggcg gcccctcttc tatgtggtca gcctgctact gcccagcatc    900

ttcctcatgg tcatggacat cgtgggcttc tacctgcccc ccaacagtgg cgagagggtc    960

tctttcaaga ttacactcct cctgggctac tcggtcttcc tgatcatcgt ttctgacacg   1020

ctgccggcca ctgccatcgg cactcctctc attggtaagg cccctcctgg cagcagagct   1080

cagtctggtg agaaacccgc cccctcccac ctcctgcatg tgtctcttgc ctctgccctg   1140

ggctgcacag gtgtctactt tgtggtgtgc atggctctgc tggtgataag tttggccgag   1200

accatcttca ttgtgcggct ggtgcacaag caagacctgc agcagcccgt gcctgcttgg   1260

ctgcgtcacc tggttctgga gagaatcgcc tggctacttt gcctgaggga gcagtcaact   1320

tcccagaggc ccccagccac ctcccaagcc accaagactg atgactgctc agccatggga   1380

aaccactgca gccacatggg aggaccccag gacttcgaga agagcccgag ggacagatgt   1440

agccctcccc caccacctcg ggaggcctcg ctggcggtgt gtgggctgct gcaggagctg   1500

tcctccatcc ggcaattcct ggaaaagcgg gatgagatcc gagaggtggc ccgagactgg   1560

ctgcgcgtgg gctccgtgct ggacaagctg ctattccaca tttacctgct agcggtgctg   1620

gcctacagca tcaccctggt tatgctctgg tccatctggc agtacgcttg agtgggtaca   1680

gcccagtgga ggagggggta cagtcctggt taggtgggga cagaggattt ctgcttaggc   1740

ccctcaggac ccagggaatg ccagggacat tttcaagaca cagacaaagt cccgtgccct   1800

gtttccaatg ccaattcatc tcagcaatca caagccaagg tctgaaccct tccaccaaaa   1860

actgggtgtt caaggccctt acacccttgt cccaccccca gcagctcacc atggctttaa   1920

aacatgctct cttagatcag gagaaactcg ggcactccct aagtccactc tagttgtgga   1980

cttttcccca ttgaccctca cctgaataag ggactttgga attctgcttc tctttcacaa   2040

ctttgctttt aggttgaagg caaaaccaac tctctactac acaggcctga taactctgta   2100

cgaggcttct ctaaccccta gtgtcttttt tttcttcacc tcacttgtgg cagcttccct   2160

gaacactcat cccccatcag atgatgggag tgggaagaat aaaatgcagt gaaaccctaa   2220

aaaaaaaaaa aaaaaaaaaa aaa                                           2243


<210>  498
<211>  510
<212>  PRT
<213>  Homosapiens

<400>  498

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
            20                  25                  30          


Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
        35                  40                  45              


Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
    50                  55                  60                  


Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
65                  70                  75                  80  


Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                85                  90                  95      


Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
            100                 105                 110         


Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
        115                 120                 125             


Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
    130                 135                 140                 


Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
145                 150                 155                 160 


Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                165                 170                 175     


Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
            180                 185                 190         


Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
        195                 200                 205             


Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
    210                 215                 220                 


Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
225                 230                 235                 240 


Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                245                 250                 255     


Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
            260                 265                 270         


Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
        275                 280                 285             


Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
    290                 295                 300                 


Ile Gly Lys Ala Pro Pro Gly Ser Arg Ala Gln Ser Gly Glu Lys Pro 
305                 310                 315                 320 


Ala Pro Ser His Leu Leu His Val Ser Leu Ala Ser Ala Leu Gly Cys 
                325                 330                 335     


Thr Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
            340                 345                 350         


Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
        355                 360                 365             


Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
    370                 375                 380                 


Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
385                 390                 395                 400 


Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
                405                 410                 415     


Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
            420                 425                 430         


Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
        435                 440                 445             


Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
    450                 455                 460                 


Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
465                 470                 475                 480 


Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
                485                 490                 495     


Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
            500                 505                 510 


<210>  499
<211>  2417
<212>  DNA
<213>  Homosapiens

<400>  499
gcagcagaga ggagttgagg gcgatgagag cgggtactgc gaactgccgg gcgatgctgt     60

cgctgccgcc gtgatacgga gagcaacagt tccccagcaa cacccctccc cgacacaggc    120

acacaccccc cgacaggcac gcacacccac cccacagtgc ccggctcggc tgcgcctcct    180

ctattggccc aggaagccca cccagccccg ccacgcagag cccagaagga aagaaagcct    240

catgcctgag ccgaggggag caccatggat ctgacaaaaa tgggcatgat ccagctgcag    300

aaccctagcc accccacggg gctactgtgc aaggccaacc agatgcggct ggccgggact    360

ttgtgcgatg tggtcatcat ggtggacagc caggagttcc acgcccaccg gacggtgctg    420

gcctgcacca gcaagatgtt tgagatcctc ttccaccgca atagtcaaca ctatactttg    480

gacttcctct cgccaaagac cttccagcag attctggagt atgcatatac agccacgctg    540

caagccaagg cggaggacct ggatgacctg ctgtatgcgg ccgagatcct ggagatcgag    600

tacctggagg aacagtgcct gaagatgctg gagaccatcc aggcctcaga cgacaatgac    660

acggaggcca ccatggccga tggcggggcc gaggaagaag aggaccgcaa ggctcggtac    720

ctcaagaaca tcttcatctc gaagcattcc agcgaggaga gtgggtatgc cagtgtggct    780

ggacagagcc tccctgggcc catggtggac cagagccctt cagtctccac ttcatttggt    840

ctttcagcca tgagtcccac caaggctgca gtggacagtt tgatgaccat aggacagtct    900

ctcctgcagg gaactcttca gccacctgca gggcccgagg agccaactct ggctgggggt    960

gggcggcacc ctggggtggc tgaggtgaag acggagatga tgcaggtgga tgaggtgccc   1020

agccaggaca gccctggggc agccgagtcc agcatctcag gagggatggg ggacaaggtt   1080

gaggaaagag gcaaagaggg gcctgggacc ccgactcgaa gcagcgtcat caccagtgct   1140

agggagctac actatgggcg agaggagagt gccgagcagg tgccaccccc agctgaggct   1200

ggccaggccc ccactggccg acctgagcac ccagcacccc cgcctgagaa gcatctgggc   1260

atctactccg tgttgcccaa ccacaaggct gacgctgtat tgagcatgcc gtcttccgtg   1320

acctctggcc tccacgtgca gcctgccctg gctgtctcca tggacttcag cacctatggg   1380

gggctgctgc cccagggctt catccagagg gagctgttca gcaagctggg ggagctggct   1440

gtgggcatga agtcagagag ccggaccatc ggagagcagt gcagcgtgtg tggggtcgag   1500

cttcctgata acgaggctgt ggagcagcac aggaagctgc acagtgggat gaagacgtac   1560

gggtgcgagc tctgcgggaa gcggttcctg gatagtttgc ggctgagaat gcacttactg   1620

gctcattcag cgggtgccaa agcctttgtc tgtgatcagt gcggtgcaca gttttcgaag   1680

gaggatgccc tggagacaca caggcagacc catactggca ctgacatggc cgtcttctgt   1740

ctgctgtgtg ggaagcgctt ccaggcgcag agcgcactgc agcagcacat ggaggtccac   1800

gcgggcgtgc gcagctacat ctgcagtgag tgcaaccgca ccttccccag ccacacggct   1860

ctcaaacgcc acctgcgctc acatacaggc gaccacccct acgagtgtga gttctgtggc   1920

agctgcttcc gggatgagag cacactcaag agccacaaac gcatccacac gggtgagaaa   1980

ccctacgagt gcaatggctg tggcaagaag ttcagcctca agcatcagct ggagacgcac   2040

tatagggtgc acacaggtga gaagcccttt gagtgtaagc tctgccacca gcgctcccgg   2100

gactactcgg ccatgatcaa gcacctgaga acgcacaacg gcgcctcgcc ctaccagtgc   2160

accatctgca cagagtactg ccccagcctc tcctccatgc agaagcacat gaagggccac   2220

aagcccgagg agatcccgcc cgactggagg atagagaaga cgtacctcta cctgtgctat   2280

gtgtgaaggg aggcccgcgg cggtggagcc gagcggggag ccaggaaaga agagttggag   2340

tgagatgaag gaaggactat gacaaataaa aaaggaaaag aaaaaaaaaa acagaaggaa   2400

aaggaaaaaa aaaaaaa                                                  2417


<210>  500
<211>  673
<212>  PRT
<213>  Homosapiens

<400>  500

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
1               5                   10                  15      


Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
            20                  25                  30          


Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
        35                  40                  45              


Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
    50                  55                  60                  


Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
65                  70                  75                  80  


Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                85                  90                  95      


Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
            100                 105                 110         


Tyr Leu Glu Glu Gln Cys Leu Lys Met Leu Glu Thr Ile Gln Ala Ser 
        115                 120                 125             


Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Asp Gly Gly Ala Glu Glu 
    130                 135                 140                 


Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
145                 150                 155                 160 


His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Gly Gln Ser Leu 
                165                 170                 175     


Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
            180                 185                 190         


Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
        195                 200                 205             


Ile Gly Gln Ser Leu Leu Gln Gly Thr Leu Gln Pro Pro Ala Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Gly Val Ala Glu 
225                 230                 235                 240 


Val Lys Thr Glu Met Met Gln Val Asp Glu Val Pro Ser Gln Asp Ser 
                245                 250                 255     


Pro Gly Ala Ala Glu Ser Ser Ile Ser Gly Gly Met Gly Asp Lys Val 
            260                 265                 270         


Glu Glu Arg Gly Lys Glu Gly Pro Gly Thr Pro Thr Arg Ser Ser Val 
        275                 280                 285             


Ile Thr Ser Ala Arg Glu Leu His Tyr Gly Arg Glu Glu Ser Ala Glu 
    290                 295                 300                 


Gln Val Pro Pro Pro Ala Glu Ala Gly Gln Ala Pro Thr Gly Arg Pro 
305                 310                 315                 320 


Glu His Pro Ala Pro Pro Pro Glu Lys His Leu Gly Ile Tyr Ser Val 
                325                 330                 335     


Leu Pro Asn His Lys Ala Asp Ala Val Leu Ser Met Pro Ser Ser Val 
            340                 345                 350         


Thr Ser Gly Leu His Val Gln Pro Ala Leu Ala Val Ser Met Asp Phe 
        355                 360                 365             


Ser Thr Tyr Gly Gly Leu Leu Pro Gln Gly Phe Ile Gln Arg Glu Leu 
    370                 375                 380                 


Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met Lys Ser Glu Ser Arg 
385                 390                 395                 400 


Thr Ile Gly Glu Gln Cys Ser Val Cys Gly Val Glu Leu Pro Asp Asn 
                405                 410                 415     


Glu Ala Val Glu Gln His Arg Lys Leu His Ser Gly Met Lys Thr Tyr 
            420                 425                 430         


Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp Ser Leu Arg Leu Arg 
        435                 440                 445             


Met His Leu Leu Ala His Ser Ala Gly Ala Lys Ala Phe Val Cys Asp 
    450                 455                 460                 


Gln Cys Gly Ala Gln Phe Ser Lys Glu Asp Ala Leu Glu Thr His Arg 
465                 470                 475                 480 


Gln Thr His Thr Gly Thr Asp Met Ala Val Phe Cys Leu Leu Cys Gly 
                485                 490                 495     


Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln His Met Glu Val His 
            500                 505                 510         


Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys Asn Arg Thr Phe Pro 
        515                 520                 525             


Ser His Thr Ala Leu Lys Arg His Leu Arg Ser His Thr Gly Asp His 
    530                 535                 540                 


Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Leu Lys Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                565                 570                 575     


Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His Gln Leu Glu Thr His 
            580                 585                 590         


Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Lys Leu Cys His 
        595                 600                 605             


Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys His Leu Arg Thr His 
    610                 615                 620                 


Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys Thr Glu Tyr Cys Pro 
625                 630                 635                 640 


Ser Leu Ser Ser Met Gln Lys His Met Lys Gly His Lys Pro Glu Glu 
                645                 650                 655     


Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr Leu Tyr Leu Cys Tyr 
            660                 665                 670         


Val 
    


<210>  501
<211>  2262
<212>  DNA
<213>  Homosapiens

<400>  501
gcgctcccgg ccgctctcgc ctcctctatt ggcccaggaa gcccacccag ccccgccacg     60

cagagcccag aaggaaagaa agcctcatgc ctgagccgag gggagcacca tggatctgac    120

aaaaatgggc atgatccagc tgcagaaccc tagccacccc acggggctac tgtgcaaggc    180

caaccagatg cggctggccg ggactttgtg cgatgtggtc atcatggtgg acagccagga    240

gttccacgcc caccggacgg tgctggcctg caccagcaag atgtttgaga tcctcttcca    300

ccgcaatagt caacactata ctttggactt cctctcgcca aagaccttcc agcagattct    360

ggagtatgca tatacagcca cgctgcaagc caaggcggag gacctggatg acctgctgta    420

tgcggccgag atcctggaga tcgagtacct ggaggaacag tgcctgaaga tgctggagac    480

catccaggcc tcagacgaca atgacacgga ggccaccatg gccgatggcg gggccgagga    540

agaagaggac cgcaaggctc ggtacctcaa gaacatcttc atctcgaagc attccagcga    600

ggagagtggg tatgccagtg tggctggaca gagcctccct gggcccatgg tggaccagag    660

cccttcagtc tccacttcat ttggtctttc agccatgagt cccaccaagg ctgcagtgga    720

cagtttgatg accataggac agtctctcct gcagggaact cttcagccac ctgcagggcc    780

cgaggagcca actctggctg ggggtgggcg gcaccctggg gtggctgagg tgaagacgga    840

gatgatgcag gtggatgagg tgcccagcca ggacagccct ggggcagccg agtccagcat    900

ctcaggaggg atgggggaca aggttgagga aagaggcaaa gaggggcctg ggaccccgac    960

tcgaagcagc gtcatcacca gtgctaggga gctacactat gggcgagagg agagtgccga   1020

gcaggtgcca cccccagctg aggctggcca ggcccccact ggccgacctg agcacccagc   1080

acccccgcct gagaagcatc tgggcatcta ctccgtgttg cccaaccaca aggctgacgc   1140

tgtattgagc atgccgtctt ccgtgacctc tggcctccac gtgcagcctg ccctggctgt   1200

ctccatggac ttcagcacct atggggggct gctgccccag ggcttcatcc agagggagct   1260

gttcagcaag ctgggggagc tggctgtggg catgaagtca gagagccgga ccatcggaga   1320

gcagtgcagc gtgtgtgggg tcgagcttcc tgataacgag gctgtggagc agcacaggaa   1380

gctgcacagt gggatgaaga cgtacgggtg cgagctctgc gggaagcggt tcctggatag   1440

tttgcggctg agaatgcact tactggctca ttcagcgggt gccaaagcct ttgtctgtga   1500

tcagtgcggt gcacagtttt cgaaggagga tgccctggag acacacaggc agacccatac   1560

tggcactgac atggccgtct tctgtctgct gtgtgggaag cgcttccagg cgcagagcgc   1620

actgcagcag cacatggagg tccacgcggg cgtgcgcagc tacatctgca gtgagtgcaa   1680

ccgcaccttc cccagccaca cggctctcaa acgccacctg cgctcacata caggcgacca   1740

cccctacgag tgtgagttct gtggcagctg cttccgggat gagagcacac tcaagagcca   1800

caaacgcatc cacacgggtg agaaacccta cgagtgcaat ggctgtggca agaagttcag   1860

cctcaagcat cagctggaga cgcactatag ggtgcacaca ggtgagaagc cctttgagtg   1920

taagctctgc caccagcgct cccgggacta ctcggccatg atcaagcacc tgagaacgca   1980

caacggcgcc tcgccctacc agtgcaccat ctgcacagag tactgcccca gcctctcctc   2040

catgcagaag cacatgaagg gccacaagcc cgaggagatc ccgcccgact ggaggataga   2100

gaagacgtac ctctacctgt gctatgtgtg aagggaggcc cgcggcggtg gagccgagcg   2160

gggagccagg aaagaagagt tggagtgaga tgaaggaagg actatgacaa ataaaaaagg   2220

aaaagaaaaa aaaaaacaga aggaaaagga aaaaaaaaaa aa                      2262


<210>  502
<211>  673
<212>  PRT
<213>  Homosapiens

<400>  502

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
1               5                   10                  15      


Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
            20                  25                  30          


Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
        35                  40                  45              


Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
    50                  55                  60                  


Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
65                  70                  75                  80  


Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                85                  90                  95      


Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
            100                 105                 110         


Tyr Leu Glu Glu Gln Cys Leu Lys Met Leu Glu Thr Ile Gln Ala Ser 
        115                 120                 125             


Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Asp Gly Gly Ala Glu Glu 
    130                 135                 140                 


Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
145                 150                 155                 160 


His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Gly Gln Ser Leu 
                165                 170                 175     


Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
            180                 185                 190         


Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
        195                 200                 205             


Ile Gly Gln Ser Leu Leu Gln Gly Thr Leu Gln Pro Pro Ala Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Gly Val Ala Glu 
225                 230                 235                 240 


Val Lys Thr Glu Met Met Gln Val Asp Glu Val Pro Ser Gln Asp Ser 
                245                 250                 255     


Pro Gly Ala Ala Glu Ser Ser Ile Ser Gly Gly Met Gly Asp Lys Val 
            260                 265                 270         


Glu Glu Arg Gly Lys Glu Gly Pro Gly Thr Pro Thr Arg Ser Ser Val 
        275                 280                 285             


Ile Thr Ser Ala Arg Glu Leu His Tyr Gly Arg Glu Glu Ser Ala Glu 
    290                 295                 300                 


Gln Val Pro Pro Pro Ala Glu Ala Gly Gln Ala Pro Thr Gly Arg Pro 
305                 310                 315                 320 


Glu His Pro Ala Pro Pro Pro Glu Lys His Leu Gly Ile Tyr Ser Val 
                325                 330                 335     


Leu Pro Asn His Lys Ala Asp Ala Val Leu Ser Met Pro Ser Ser Val 
            340                 345                 350         


Thr Ser Gly Leu His Val Gln Pro Ala Leu Ala Val Ser Met Asp Phe 
        355                 360                 365             


Ser Thr Tyr Gly Gly Leu Leu Pro Gln Gly Phe Ile Gln Arg Glu Leu 
    370                 375                 380                 


Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met Lys Ser Glu Ser Arg 
385                 390                 395                 400 


Thr Ile Gly Glu Gln Cys Ser Val Cys Gly Val Glu Leu Pro Asp Asn 
                405                 410                 415     


Glu Ala Val Glu Gln His Arg Lys Leu His Ser Gly Met Lys Thr Tyr 
            420                 425                 430         


Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp Ser Leu Arg Leu Arg 
        435                 440                 445             


Met His Leu Leu Ala His Ser Ala Gly Ala Lys Ala Phe Val Cys Asp 
    450                 455                 460                 


Gln Cys Gly Ala Gln Phe Ser Lys Glu Asp Ala Leu Glu Thr His Arg 
465                 470                 475                 480 


Gln Thr His Thr Gly Thr Asp Met Ala Val Phe Cys Leu Leu Cys Gly 
                485                 490                 495     


Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln His Met Glu Val His 
            500                 505                 510         


Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys Asn Arg Thr Phe Pro 
        515                 520                 525             


Ser His Thr Ala Leu Lys Arg His Leu Arg Ser His Thr Gly Asp His 
    530                 535                 540                 


Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Leu Lys Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                565                 570                 575     


Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His Gln Leu Glu Thr His 
            580                 585                 590         


Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Lys Leu Cys His 
        595                 600                 605             


Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys His Leu Arg Thr His 
    610                 615                 620                 


Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys Thr Glu Tyr Cys Pro 
625                 630                 635                 640 


Ser Leu Ser Ser Met Gln Lys His Met Lys Gly His Lys Pro Glu Glu 
                645                 650                 655     


Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr Leu Tyr Leu Cys Tyr 
            660                 665                 670         


Val 
    


<210>  503
<211>  3921
<212>  DNA
<213>  Homosapiens

<400>  503
catgccttat gcaagagacc tcagtccccc ggaacaactc gatttccttc caatagaggt     60

ctgaggtgga ctcccacctc ccttcgtgaa gagttccctc ctctccccct tcctaagaaa    120

gtcgatcttg gctctatttg tgtcttatgt tcatcaccct cattcctccg gagaaagccg    180

ggttggttta tgtctttatt tattcccggg gccaagacgt ccggaacctg tggctgcgca    240

gacccggcac tgataggcga agacggagag aaatttacct cccgccgctg ccccccagcc    300

aaacgtgaca gcgcgcgggc cggttgcgtg actcgtgacg tctccaagtc ctataggtgc    360

agcggctggt gagatagtcg ctatcgcctg gttgcctctt tattttactg gggtatgcct    420

ggtaataaac agtaatattt aatttgtcgg agaccacaaa ccaaccttga gctgggaggt    480

acgtgctctt cttgacagac gttggaagaa gacctggcct aaagaggtct cttttggtgg    540

tccttttcaa agtcttcacc tgagccctgc tctccagcga ggcgcactcc tggcttttgc    600

gctccaaaga agaggtggga tagttggaga gcagaacctt gcgcgggcac agggccctgg    660

gcgcaccatg gccgacgcag acgagggctt tggcctggcg cacacgcctc tggagcctga    720

cgcaaaagac ctgccctgcg attcgaaacc cgagagcgcg ctcggggccc ccagcaagtc    780

cccgtcgtcc ccgcaggccg ccttcaccca gcagggcatg gagggaatca aagtgtttct    840

ccatgaaaga gaactgtggc taaaattcca cgaagtgggc acggaaatga tcataaccaa    900

ggctggaagg cggatgtttc ccagttacaa agtgaaggtg acgggcctta atcccaaaac    960

gaagtacatt cttctcatgg acattgtacc tgccgacgat cacagataca aattcgcaga   1020

taataaatgg tctgtgacgg gcaaagctga gcccgccatg cctggccgcc tgtacgtgca   1080

cccagactcc cccgccaccg gggcgcattg gatgaggcag ctcgtctcct tccagaaact   1140

caagctcacc aacaaccacc tggacccatt tgggcatatt attctaaatt ccatgcacaa   1200

ataccagcct agattacaca tcgtgaaagc ggatgaaaat aatggatttg gctcaaaaaa   1260

tacagcgttc tgcactcacg tctttcctga gactgcgttt atagcagtga cttcctacca   1320

gaaccacaag atcacgcaat taaagattga gaataatccc tttgccaaag gatttcgggg   1380

cagtgatgac atggagctgc acagaatgtc aagaatgcaa agtaaagaat atcccgtggt   1440

ccccaggagc accgtgaggc aaaaagtggc ctccaaccac agtcctttca gcagcgagtc   1500

tcgagctctc tccacctcat ccaatttggg gtcccaatac cagtgtgaga atggtgtttc   1560

cggcccctcc caggacctcc tgcctccacc caacccatac ccactgcccc aggagcatag   1620

ccaaatttac cattgtacca agaggaaaga ggaagaatgt tccaccacag accatcccta   1680

taagaagccc tacatggaga catcacccag tgaagaagat tccttctacc gctctagcta   1740

tccacagcag cagggcctgg gtgcctccta caggacagag tcggcacagc ggcaagcttg   1800

catgtatgcc agctctgcgc cccccagcga gcctgtgccc agcctagagg acatcagctg   1860

caacacgtgg ccaagcatgc cttcctacag cagctgcacc gtcaccaccg tgcagcccat   1920

ggacaggcta ccctaccagc acttctccgc tcacttcacc tcggggcccc tggtccctcg   1980

gctggctggc atggccaacc atggctcccc acagctggga gagggaatgt tccagcacca   2040

gacctccgtg gcccaccagc ctgtggtcag gcagtgtggg cctcagactg gcctgcagtc   2100

ccctggcacc cttcagcccc ctgagttcct ctactctcat ggcgtgccaa ggactctatc   2160

ccctcatcag taccactctg tgcacggagt tggcatggtg ccagagtgga gcgacaatag   2220

ctaaagtgag gcctgcttca caacagacat ttcctagaga aagagagaga gagaggagaa   2280

agagagagaa ggagagagac agtagccaag agaaccccac ggacaagatt tttcatttca   2340

cccaatgttc acatctgcac tcaaggtcgc tggatgctga tctaatcagt agcttgaaac   2400

cacaatttta aaaatgtgac tttcttgttt tgtctcaaaa cttaaaaaaa caaacacaaa   2460

aagatgagtc ccacccccca ctaccaccac acccatcaac cagccacatt cacgctactc   2520

cccagatctc ttcccccatt ccttcttttg ggctctagaa agtcttgcct cattgagtgt   2580

ttttccctag tgcgtagttg gagtctgtcc ctgtcttggt gttaatgttg acattgttat   2640

ataataaatg ataatatatt tttttctttc aattttctta atgggaccca gtcccttatt   2700

tggggggagg tctgaggcaa gtatatttca aaatatgtac ttgcgggatt cccttcaagt   2760

aaaccatccc tgaaacctaa attcacgttt ccccttgact aagaaaagca cctacctctg   2820

ccatgtgatg tttctgaaaa gcctctgtat gtccccattt gctttggttt tgtcctgcct   2880

tctccaatat cacgtgctca gttttgcctc tacttaccca tggagtcagg ataacactga   2940

cgctccctgg catcctatct tattcagccc taccatcttg ccagctctgt ctttccagct   3000

gtctgtcgct aaaacgtggc ctatagcttc ccttccggaa agcttgcttt gaaaaactta   3060

aaaagccccc gtttacatgt aggcaggact gtgataacag tgcaagctct gtgttgacaa   3120

gagttgtgga caaaaagcca aaataaatat tcttcctgat taaaaaaatt ttttttgaaa   3180

aaaacaaggc cagccccaac cttccaaacc tccatcacca acaacccaaa ctggatgtca   3240

agcaaaatgc acaattccta cagaagaggc aagacacagt caccaatgat atctcgccaa   3300

agaaaccacg cccacaccaa tgccaacaca aaactgtgtt tactgaaagc cgaaaacagt   3360

attaaaaaaa gtgtgtaagt aaagtgttat ggtagggttc ttcagatgta atattttact   3420

ggtactattt atttataaat aggaattcta attaagtaat aacatgaaat gaaacccagc   3480

ataggagctg gccaagagct tttaatttta ttgatactca aaaccaagtt tgtgtttttt   3540

tgtttttttt tgtttttttc ctctttcgaa tgtgctttgc tttttttgat taaaaagaat   3600

tttttttttc cttttttata aacagaccct aataaagaga acagggtaag atgtgaggct   3660

gagtgtgttt aagtacgtga gagagtgtga gtgtgtttgt aagtgagtgt ccctatgcga   3720

ttatgtctct ttacgttgct aaggggggag ggtgaggatt aagtactcgt gccttatatt   3780

tgtgtgccaa ttaatgccta ataaatacca tgtgcttaaa caagtaaaaa aaaaaaaaaa   3840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3900

aaaaaaaaaa aaaaaaaaaa a                                             3921


<210>  504
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  504

Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
1               5                   10                  15      


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
            20                  25                  30          


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
        35                  40                  45              


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
    50                  55                  60                  


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
65                  70                  75                  80  


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
                85                  90                  95      


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
            100                 105                 110         


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
        115                 120                 125             


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
    130                 135                 140                 


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
145                 150                 155                 160 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
                165                 170                 175     


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
            180                 185                 190         


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
        195                 200                 205             


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
    210                 215                 220                 


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
225                 230                 235                 240 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
                245                 250                 255     


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
            260                 265                 270         


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
        275                 280                 285             


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
    290                 295                 300                 


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
305                 310                 315                 320 


Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His 
                325                 330                 335     


Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser 
            340                 345                 350         


Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr 
        355                 360                 365             


Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala 
    370                 375                 380                 


Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr 
385                 390                 395                 400 


Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln 
                405                 410                 415     


Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser 
            420                 425                 430         


Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro 
        435                 440                 445             


Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln 
    450                 455                 460                 


Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly 
465                 470                 475                 480 


Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr 
                485                 490                 495     


Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro 
            500                 505                 510         


Glu Trp Ser Asp Asn Ser 
        515             


<210>  505
<211>  3736
<212>  DNA
<213>  Homosapiens

<400>  505
catgccttat gcaagagacc tcagtccccc ggaacaactc gatttccttc caatagaggt     60

ctgaggtgga ctcccacctc ccttcgtgaa gagttccctc ctctccccct tcctaagaaa    120

gtcgatcttg gctctatttg tgtcttatgt tcatcaccct cattcctccg gagaaagccg    180

ggttggttta tgtctttatt tattcccggg gccaagacgt ccggaacctg tggctgcgca    240

gacccggcac tgataggcga agacggagag aaatttacct cccgccgctg ccccccagcc    300

aaacgtgaca gcgcgcgggc cggttgcgtg actcgtgacg tctccaagtc ctataggtgc    360

agcggctggt gagatagtcg ctatcgcctg gttgcctctt tattttactg gggtatgcct    420

ggtaataaac agtaatattt aatttgtcgg agaccacaaa ccaaccttga gctgggaggt    480

acgtgctctt cttgacagac gttggaagaa gacctggcct aaagaggtct cttttggtgg    540

tccttttcaa agtcttcacc tgagccctgc tctccagcga ggcgcactcc tggcttttgc    600

gctccaaaga agaggtggga tagttggagg gcatggaggg aatcaaagtg tttctccatg    660

aaagagaact gtggctaaaa ttccacgaag tgggcacgga aatgatcata accaaggctg    720

gaaggcggat gtttcccagt tacaaagtga aggtgacggg ccttaatccc aaaacgaagt    780

acattcttct catggacatt gtacctgccg acgatcacag atacaaattc gcagataata    840

aatggtctgt gacgggcaaa gctgagcccg ccatgcctgg ccgcctgtac gtgcacccag    900

actcccccgc caccggggcg cattggatga ggcagctcgt ctccttccag aaactcaagc    960

tcaccaacaa ccacctggac ccatttgggc atattattct aaattccatg cacaaatacc   1020

agcctagatt acacatcgtg aaagcggatg aaaataatgg atttggctca aaaaatacag   1080

cgttctgcac tcacgtcttt cctgagactg cgtttatagc agtgacttcc taccagaacc   1140

acaagatcac gcaattaaag attgagaata atccctttgc caaaggattt cggggcagtg   1200

atgacatgga gctgcacaga atgtcaagaa tgcaaagtaa agaatatccc gtggtcccca   1260

ggagcaccgt gaggcaaaaa gtggcctcca accacagtcc tttcagcagc gagtctcgag   1320

ctctctccac ctcatccaat ttggggtccc aataccagtg tgagaatggt gtttccggcc   1380

cctcccagga cctcctgcct ccacccaacc catacccact gccccaggag catagccaaa   1440

tttaccattg taccaagagg aaagaggaag aatgttccac cacagaccat ccctataaga   1500

agccctacat ggagacatca cccagtgaag aagattcctt ctaccgctct agctatccac   1560

agcagcaggg cctgggtgcc tcctacagga cagagtcggc acagcggcaa gcttgcatgt   1620

atgccagctc tgcgcccccc agcgagcctg tgcccagcct agaggacatc agctgcaaca   1680

cgtggccaag catgccttcc tacagcagct gcaccgtcac caccgtgcag cccatggaca   1740

ggctacccta ccagcacttc tccgctcact tcacctcggg gcccctggtc cctcggctgg   1800

ctggcatggc caaccatggc tccccacagc tgggagaggg aatgttccag caccagacct   1860

ccgtggccca ccagcctgtg gtcaggcagt gtgggcctca gactggcctg cagtcccctg   1920

gcacccttca gccccctgag ttcctctact ctcatggcgt gccaaggact ctatcccctc   1980

atcagtacca ctctgtgcac ggagttggca tggtgccaga gtggagcgac aatagctaaa   2040

gtgaggcctg cttcacaaca gacatttcct agagaaagag agagagagag gagaaagaga   2100

gagaaggaga gagacagtag ccaagagaac cccacggaca agatttttca tttcacccaa   2160

tgttcacatc tgcactcaag gtcgctggat gctgatctaa tcagtagctt gaaaccacaa   2220

ttttaaaaat gtgactttct tgttttgtct caaaacttaa aaaaacaaac acaaaaagat   2280

gagtcccacc ccccactacc accacaccca tcaaccagcc acattcacgc tactccccag   2340

atctcttccc ccattccttc ttttgggctc tagaaagtct tgcctcattg agtgtttttc   2400

cctagtgcgt agttggagtc tgtccctgtc ttggtgttaa tgttgacatt gttatataat   2460

aaatgataat atattttttt ctttcaattt tcttaatggg acccagtccc ttatttgggg   2520

ggaggtctga ggcaagtata tttcaaaata tgtacttgcg ggattccctt caagtaaacc   2580

atccctgaaa cctaaattca cgtttcccct tgactaagaa aagcacctac ctctgccatg   2640

tgatgtttct gaaaagcctc tgtatgtccc catttgcttt ggttttgtcc tgccttctcc   2700

aatatcacgt gctcagtttt gcctctactt acccatggag tcaggataac actgacgctc   2760

cctggcatcc tatcttattc agccctacca tcttgccagc tctgtctttc cagctgtctg   2820

tcgctaaaac gtggcctata gcttcccttc cggaaagctt gctttgaaaa acttaaaaag   2880

cccccgttta catgtaggca ggactgtgat aacagtgcaa gctctgtgtt gacaagagtt   2940

gtggacaaaa agccaaaata aatattcttc ctgattaaaa aaattttttt tgaaaaaaac   3000

aaggccagcc ccaaccttcc aaacctccat caccaacaac ccaaactgga tgtcaagcaa   3060

aatgcacaat tcctacagaa gaggcaagac acagtcacca atgatatctc gccaaagaaa   3120

ccacgcccac accaatgcca acacaaaact gtgtttactg aaagccgaaa acagtattaa   3180

aaaaagtgtg taagtaaagt gttatggtag ggttcttcag atgtaatatt ttactggtac   3240

tatttattta taaataggaa ttctaattaa gtaataacat gaaatgaaac ccagcatagg   3300

agctggccaa gagcttttaa ttttattgat actcaaaacc aagtttgtgt ttttttgttt   3360

ttttttgttt ttttcctctt tcgaatgtgc tttgcttttt ttgattaaaa agaatttttt   3420

ttttcctttt ttataaacag accctaataa agagaacagg gtaagatgtg aggctgagtg   3480

tgtttaagta cgtgagagag tgtgagtgtg tttgtaagtg agtgtcccta tgcgattatg   3540

tctctttacg ttgctaaggg gggagggtga ggattaagta ctcgtgcctt atatttgtgt   3600

gccaattaat gcctaataaa taccatgtgc ttaaacaagt aaaaaaaaaa aaaaaaaaaa   3660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3720

aaaaaaaaaa aaaaaa                                                   3736


<210>  506
<211>  468
<212>  PRT
<213>  Homosapiens

<400>  506

Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp Leu Lys 
1               5                   10                  15      


Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg 
            20                  25                  30          


Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro Lys Thr 
        35                  40                  45              


Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His Arg Tyr 
    50                  55                  60                  


Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu Pro Ala 
65                  70                  75                  80  


Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala 
                85                  90                  95      


His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu Thr Asn 
            100                 105                 110         


Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys 
        115                 120                 125             


Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Gly Phe 
    130                 135                 140                 


Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ala 
145                 150                 155                 160 


Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys 
                165                 170                 175     


Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Met 
            180                 185                 190         


Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro Val Val 
        195                 200                 205             


Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser Pro Phe 
    210                 215                 220                 


Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly Ser Gln 
225                 230                 235                 240 


Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu Leu Pro 
                245                 250                 255     


Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile Tyr His 
            260                 265                 270         


Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His Pro Tyr 
        275                 280                 285             


Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser Phe Tyr 
    290                 295                 300                 


Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr Arg Thr 
305                 310                 315                 320 


Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala Pro Pro 
                325                 330                 335     


Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr Trp Pro 
            340                 345                 350         


Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln Pro Met 
        355                 360                 365             


Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser Gly Pro 
    370                 375                 380                 


Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro Gln Leu 
385                 390                 395                 400 


Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln Pro Val 
                405                 410                 415     


Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly Thr Leu 
            420                 425                 430         


Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr Leu Ser 
        435                 440                 445             


Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro Glu Trp 
    450                 455                 460                 


Ser Asp Asn Ser 
465             


<210>  507
<211>  1050
<212>  DNA
<213>  Homosapiens

<400>  507
atggccgacg cagacgaggg ctttggcctg gcgcacacgc ctctggagcc tgacgcaaaa     60

gacctgccct gcgattcgaa acccgagagc gcgctcgggg cccccagcaa gtccccgtcg    120

tccccgcagg ccgccttcac ccagcagggc atggagggaa tcaaagtgtt tctccatgaa    180

agagaactgt ggctaaaatt ccacgaagtg ggcacggaaa tgatcataac caaggctgga    240

aggcggatgt ttcccagtta caaagtgaag gtgacgggcc ttaatcccaa aacgaagtac    300

attcttctca tggacattgt acctgccgac gatcacagat acaaattcgc agataataaa    360

tggtctgtga cgggcaaagc tgagcccgcc atgcctggcc gcctgtacgt gcacccagac    420

tcccccgcca ccggggcgca ttggatgagg cagctcgtct ccttccagaa actcaagctc    480

accaacaacc acctggaccc atttgggcat attattctaa attccatgca caaataccag    540

cctagattac acatcgtgaa agcggatgaa aataatggat ttggctcaaa aaatacagcg    600

ttctgcactc acgtctttcc tgagactgcg tttatagcag tgacttccta ccagaaccac    660

aagatcacgc aattaaagat tgagaataat ccctttgcca aaggatttcg gggcagtgat    720

gacatggagc tgcacagaat gtcaagaatg caaagtaaag aatatcccgt ggtccccagg    780

agcaccgtga ggcaaaaagt ggcctccaac cacagtcctt tcagcagcga gtctcgagct    840

ctctccacct catccaattt ggggtcccaa taccagtgtg agaatggtgt ttccggcccc    900

tcccaggacc tcctgcctcc acccaaccca tacccactgc cccaggagca tagccaaatt    960

taccattgta ccaagaggaa aggtgagtgt gatcacccct ggtcaatttg ctttctttct   1020

taccttttcc tttccttggg ttgggggtga                                    1050


<210>  508
<211>  349
<212>  PRT
<213>  Homosapiens

<400>  508

Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
1               5                   10                  15      


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
            20                  25                  30          


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
        35                  40                  45              


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
    50                  55                  60                  


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
65                  70                  75                  80  


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
                85                  90                  95      


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
            100                 105                 110         


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
        115                 120                 125             


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
    130                 135                 140                 


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
145                 150                 155                 160 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
                165                 170                 175     


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
            180                 185                 190         


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
        195                 200                 205             


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
    210                 215                 220                 


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
225                 230                 235                 240 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
                245                 250                 255     


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
            260                 265                 270         


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
        275                 280                 285             


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
    290                 295                 300                 


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
305                 310                 315                 320 


Tyr His Cys Thr Lys Arg Lys Gly Glu Cys Asp His Pro Trp Ser Ile 
                325                 330                 335     


Cys Phe Leu Ser Tyr Leu Phe Leu Ser Leu Gly Trp Gly 
            340                 345                 


<210>  509
<211>  3749
<212>  DNA
<213>  Homosapiens

<400>  509
ttcagagaga gagagagagg gagagagagt gagagagact gactcttacc tcgaatccgg     60

gaactttaat cctgaaagct gcgctcagaa aggacttcga ccattcactg ggcttccaac    120

tttccctccc tgggggtgta aaggaggagc ggggcactga gattatatgg ttgccggtgc    180

tcttggaggc tattttgtgt tctttggcgc ttgccaactg ggaagtattt agggagagca    240

agcgcacagc agaggaggtg tgtgttggag gtgggcagtc gccgcggagg ctccagcggt    300

aggtgcgccc tagtaggcag cagtagccgc tattctgggt aagcagtaaa ccccgcataa    360

accccggagc caccatgcct gctcccccgc ctcaccgccg gcttccctgc taggagcagc    420

agaggatgtg gtgaatgcac cggcttcacc gaacgagagc agaaccttgc gcgggcacag    480

ggccctgggc gcaccatggc cgacgcagac gagggctttg gcctggcgca cacgcctctg    540

gagcctgacg caaaagacct gccctgcgat tcgaaacccg agagcgcgct cggggccccc    600

agcaagtccc cgtcgtcccc gcaggccgcc ttcacccagc agggcatgga gggaatcaaa    660

gtgtttctcc atgaaagaga actgtggcta aaattccacg aagtgggcac ggaaatgatc    720

ataaccaagg ctggaaggcg gatgtttccc agttacaaag tgaaggtgac gggccttaat    780

cccaaaacga agtacattct tctcatggac attgtacctg ccgacgatca cagatacaaa    840

ttcgcagata ataaatggtc tgtgacgggc aaagctgagc ccgccatgcc tggccgcctg    900

tacgtgcacc cagactcccc cgccaccggg gcgcattgga tgaggcagct cgtctccttc    960

cagaaactca agctcaccaa caaccacctg gacccatttg ggcatattat tctaaattcc   1020

atgcacaaat accagcctag attacacatc gtgaaagcgg atgaaaataa tggatttggc   1080

tcaaaaaata cagcgttctg cactcacgtc tttcctgaga ctgcgtttat agcagtgact   1140

tcctaccaga accacaagat cacgcaatta aagattgaga ataatccctt tgccaaagga   1200

tttcggggca gtgatgacat ggagctgcac agaatgtcaa gaatgcaaag taaagaatat   1260

cccgtggtcc ccaggagcac cgtgaggcaa aaagtggcct ccaaccacag tcctttcagc   1320

agcgagtctc gagctctctc cacctcatcc aatttggggt cccaatacca gtgtgagaat   1380

ggtgtttccg gcccctccca ggacctcctg cctccaccca acccataccc actgccccag   1440

gagcatagcc aaatttacca ttgtaccaag aggaaagagg aagaatgttc caccacagac   1500

catccctata agaagcccta catggagaca tcacccagtg aagaagattc cttctaccgc   1560

tctagctatc cacagcagca gggcctgggt gcctcctaca ggacagagtc ggcacagcgg   1620

caagcttgca tgtatgccag ctctgcgccc cccagcgagc ctgtgcccag cctagaggac   1680

atcagctgca acacgtggcc aagcatgcct tcctacagca gctgcaccgt caccaccgtg   1740

cagcccatgg acaggctacc ctaccagcac ttctccgctc acttcacctc ggggcccctg   1800

gtccctcggc tggctggcat ggccaaccat ggctccccac agctgggaga gggaatgttc   1860

cagcaccaga cctccgtggc ccaccagcct gtggtcaggc agtgtgggcc tcagactggc   1920

ctgcagtccc ctggcaccct tcagccccct gagttcctct actctcatgg cgtgccaagg   1980

actctatccc ctcatcagta ccactctgtg cacggagttg gcatggtgcc agagtggagc   2040

gacaatagct aaagtgaggc ctgcttcaca acagacattt cctagagaaa gagagagaga   2100

gaggagaaag agagagaagg agagagacag tagccaagag aaccccacgg acaagatttt   2160

tcatttcacc caatgttcac atctgcactc aaggtcgctg gatgctgatc taatcagtag   2220

cttgaaacca caattttaaa aatgtgactt tcttgttttg tctcaaaact taaaaaaaca   2280

aacacaaaaa gatgagtccc accccccact accaccacac ccatcaacca gccacattca   2340

cgctactccc cagatctctt cccccattcc ttcttttggg ctctagaaag tcttgcctca   2400

ttgagtgttt ttccctagtg cgtagttgga gtctgtccct gtcttggtgt taatgttgac   2460

attgttatat aataaatgat aatatatttt tttctttcaa ttttcttaat gggacccagt   2520

cccttatttg gggggaggtc tgaggcaagt atatttcaaa atatgtactt gcgggattcc   2580

cttcaagtaa accatccctg aaacctaaat tcacgtttcc ccttgactaa gaaaagcacc   2640

tacctctgcc atgtgatgtt tctgaaaagc ctctgtatgt ccccatttgc tttggttttg   2700

tcctgccttc tccaatatca cgtgctcagt tttgcctcta cttacccatg gagtcaggat   2760

aacactgacg ctccctggca tcctatctta ttcagcccta ccatcttgcc agctctgtct   2820

ttccagctgt ctgtcgctaa aacgtggcct atagcttccc ttccggaaag cttgctttga   2880

aaaacttaaa aagcccccgt ttacatgtag gcaggactgt gataacagtg caagctctgt   2940

gttgacaaga gttgtggaca aaaagccaaa ataaatattc ttcctgatta aaaaaatttt   3000

ttttgaaaaa aacaaggcca gccccaacct tccaaacctc catcaccaac aacccaaact   3060

ggatgtcaag caaaatgcac aattcctaca gaagaggcaa gacacagtca ccaatgatat   3120

ctcgccaaag aaaccacgcc cacaccaatg ccaacacaaa actgtgttta ctgaaagccg   3180

aaaacagtat taaaaaaagt gtgtaagtaa agtgttatgg tagggttctt cagatgtaat   3240

attttactgg tactatttat ttataaatag gaattctaat taagtaataa catgaaatga   3300

aacccagcat aggagctggc caagagcttt taattttatt gatactcaaa accaagtttg   3360

tgtttttttg tttttttttg tttttttcct ctttcgaatg tgctttgctt tttttgatta   3420

aaaagaattt tttttttcct tttttataaa cagaccctaa taaagagaac agggtaagat   3480

gtgaggctga gtgtgtttaa gtacgtgaga gagtgtgagt gtgtttgtaa gtgagtgtcc   3540

ctatgcgatt atgtctcttt acgttgctaa ggggggaggg tgaggattaa gtactcgtgc   3600

cttatatttg tgtgccaatt aatgcctaat aaataccatg tgcttaaaca agtaaaaaaa   3660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     3749


<210>  510
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  510

Met Ala Asp Ala Asp Glu Gly Phe Gly Leu Ala His Thr Pro Leu Glu 
1               5                   10                  15      


Pro Asp Ala Lys Asp Leu Pro Cys Asp Ser Lys Pro Glu Ser Ala Leu 
            20                  25                  30          


Gly Ala Pro Ser Lys Ser Pro Ser Ser Pro Gln Ala Ala Phe Thr Gln 
        35                  40                  45              


Gln Gly Met Glu Gly Ile Lys Val Phe Leu His Glu Arg Glu Leu Trp 
    50                  55                  60                  


Leu Lys Phe His Glu Val Gly Thr Glu Met Ile Ile Thr Lys Ala Gly 
65                  70                  75                  80  


Arg Arg Met Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Leu Asn Pro 
                85                  90                  95      


Lys Thr Lys Tyr Ile Leu Leu Met Asp Ile Val Pro Ala Asp Asp His 
            100                 105                 110         


Arg Tyr Lys Phe Ala Asp Asn Lys Trp Ser Val Thr Gly Lys Ala Glu 
        115                 120                 125             


Pro Ala Met Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr 
    130                 135                 140                 


Gly Ala His Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu 
145                 150                 155                 160 


Thr Asn Asn His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met 
                165                 170                 175     


His Lys Tyr Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn 
            180                 185                 190         


Gly Phe Gly Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu 
        195                 200                 205             


Thr Ala Phe Ile Ala Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln 
    210                 215                 220                 


Leu Lys Ile Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp 
225                 230                 235                 240 


Asp Met Glu Leu His Arg Met Ser Arg Met Gln Ser Lys Glu Tyr Pro 
                245                 250                 255     


Val Val Pro Arg Ser Thr Val Arg Gln Lys Val Ala Ser Asn His Ser 
            260                 265                 270         


Pro Phe Ser Ser Glu Ser Arg Ala Leu Ser Thr Ser Ser Asn Leu Gly 
        275                 280                 285             


Ser Gln Tyr Gln Cys Glu Asn Gly Val Ser Gly Pro Ser Gln Asp Leu 
    290                 295                 300                 


Leu Pro Pro Pro Asn Pro Tyr Pro Leu Pro Gln Glu His Ser Gln Ile 
305                 310                 315                 320 


Tyr His Cys Thr Lys Arg Lys Glu Glu Glu Cys Ser Thr Thr Asp His 
                325                 330                 335     


Pro Tyr Lys Lys Pro Tyr Met Glu Thr Ser Pro Ser Glu Glu Asp Ser 
            340                 345                 350         


Phe Tyr Arg Ser Ser Tyr Pro Gln Gln Gln Gly Leu Gly Ala Ser Tyr 
        355                 360                 365             


Arg Thr Glu Ser Ala Gln Arg Gln Ala Cys Met Tyr Ala Ser Ser Ala 
    370                 375                 380                 


Pro Pro Ser Glu Pro Val Pro Ser Leu Glu Asp Ile Ser Cys Asn Thr 
385                 390                 395                 400 


Trp Pro Ser Met Pro Ser Tyr Ser Ser Cys Thr Val Thr Thr Val Gln 
                405                 410                 415     


Pro Met Asp Arg Leu Pro Tyr Gln His Phe Ser Ala His Phe Thr Ser 
            420                 425                 430         


Gly Pro Leu Val Pro Arg Leu Ala Gly Met Ala Asn His Gly Ser Pro 
        435                 440                 445             


Gln Leu Gly Glu Gly Met Phe Gln His Gln Thr Ser Val Ala His Gln 
    450                 455                 460                 


Pro Val Val Arg Gln Cys Gly Pro Gln Thr Gly Leu Gln Ser Pro Gly 
465                 470                 475                 480 


Thr Leu Gln Pro Pro Glu Phe Leu Tyr Ser His Gly Val Pro Arg Thr 
                485                 490                 495     


Leu Ser Pro His Gln Tyr His Ser Val His Gly Val Gly Met Val Pro 
            500                 505                 510         


Glu Trp Ser Asp Asn Ser 
        515             


<210>  511
<211>  2092
<212>  DNA
<213>  Homosapiens

<400>  511
ctggagagag ggaagaagca acgctcagca tttcgctgat tttcaagtgc acaccgagca     60

gcgcttcagg cagctttggg tcagaacacg cctgattcgg acttcaggcg aaggcagagg    120

ccagcacggg tcaccgattc agagccgggg gcggggccga ccacacacgc tgtgagaccc    180

agaggccgag gagccgcggg ttagaaaatg tgaccttggc gaccccaacg cccccgcctc    240

cctcgctgct gctccacctg cacgcggagc gcgccgggcc gccagcggag gcgatggcca    300

gccctgcgcc cttagtggcc tccatcagcc accaaatggt ggctctgcag accttgcagc    360

tgctgcagca ggagtggggc tggggggacg gtccagtcgc ccccgggaac ccgcgggacc    420

cagaccacgt gtccaccgct ccagcccgtc gctcaggccc gccgcgggcc cggccggggc    480

ccgggcgcga ggagcggggc gggggcgtgg ggaccaggag tcggcggacc gcggcgcggg    540

tgaactcccc agaggaggag gtagtgcgag gcgctgaggg gggcgccgag ttgctgccct    600

tcccccggga ccgcgggccc tgcaccctgg cccagatggc gatgcgcagc gcgctggccc    660

gcgtggtgga ctcgacttcg gagctggtca gcgtggagca gacgctgctg gggcccctcc    720

agcaggagcg gtcctttccc attcacctga agcttcaact cctggctaat gagtgaagaa    780

ggtcactgta ggagtgtgag gaccatcagg agcttcatat ttcaataacc agtgccaaat    840

tctgaatgcc agatgggatg agatgggatg ttaaaccact tcttattacc acgttgttgg    900

cctccattgc cttcgtattg gtctccaatt gcatggtctc tgtggatctc tgacttctta    960

ttacctccga ttggaacgcg ccacaaatca tcctgctttc tttatcctct ctcacctcca   1020

agtaatcctg tcatcttgct ccaattagag ccgcttccat taagaagatc gtgacaaatt   1080

ccctacccct gtttgctctt caggaaaatt atcccctgga aaagtggatg ttatagtcgc   1140

ttttcagaat gtattgtctg aatttcttgt cttccaacat tctcctaagc cagttacctt   1200

tgcactgaag tagaattcaa aaggagatag aggttctgaa tttcttcctt tgaccagatg   1260

gaagtcgtta catcagaatg ctgatgactg caaaatcttg gacatattgt tttcacaatt   1320

aggaaatggc aaacacaaag ttcttcagtg caaagccagc atgcgagttc agcttccatt   1380

tgctgctata aattttgttc ttgttgctgc cagtaaacac caactgttca agtgaaatag   1440

taaatccaaa tgtgcctgtt ggatgagagt aaaaaaatta tatgctgcat aaatgctgat   1500

gcaaaaggat ttttcaacac actaaaccag ggtagggaaa ggaaccgaga aagaaagttg   1560

aactgaatgc agctctcact aacaacttct tggtaaaagc actaaaaaag ctcttgatag   1620

aatgttgatt caacatactg tttaaacctc aaggaaaaaa acaaacgcag aattgggata   1680

ttggccttag gatatctgct taaagtccta ctttgagctc tcatcagggt taccaaagaa   1740

ggcgtacata gattgttaca aatcaaagca aagaaaaatc ccaaagttcc ctcaaaactg   1800

atgtgggcac ttggcccaga agttgtttgc taatgatcag tctaacagct gaaagtcaaa   1860

gtcagtggct agtaccatct gcaataggat ttaggaagtt ttgatctcac aaatttactg   1920

taaggctaat caatgaatgt ttgtactcag gtctccctac agttaaattt aatgtgtaac   1980

tggaattacg attcaaagag atagtttcat aaatggtccc tgaaatttaa ttttggatta   2040

cctaagttta caatggattt ctcttctcct ttccccaata tttttcttac gc           2092


<210>  512
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  512

Met Ala Ser Pro Ala Pro Leu Val Ala Ser Ile Ser His Gln Met Val 
1               5                   10                  15      


Ala Leu Gln Thr Leu Gln Leu Leu Gln Gln Glu Trp Gly Trp Gly Asp 
            20                  25                  30          


Gly Pro Val Ala Pro Gly Asn Pro Arg Asp Pro Asp His Val Ser Thr 
        35                  40                  45              


Ala Pro Ala Arg Arg Ser Gly Pro Pro Arg Ala Arg Pro Gly Pro Gly 
    50                  55                  60                  


Arg Glu Glu Arg Gly Gly Gly Val Gly Thr Arg Ser Arg Arg Thr Ala 
65                  70                  75                  80  


Ala Arg Val Asn Ser Pro Glu Glu Glu Val Val Arg Gly Ala Glu Gly 
                85                  90                  95      


Gly Ala Glu Leu Leu Pro Phe Pro Arg Asp Arg Gly Pro Cys Thr Leu 
            100                 105                 110         


Ala Gln Met Ala Met Arg Ser Ala Leu Ala Arg Val Val Asp Ser Thr 
        115                 120                 125             


Ser Glu Leu Val Ser Val Glu Gln Thr Leu Leu Gly Pro Leu Gln Gln 
    130                 135                 140                 


Glu Arg Ser Phe Pro Ile His Leu Lys Leu Gln Leu Leu Ala Asn Glu 
145                 150                 155                 160 


<210>  513
<211>  1515
<212>  DNA
<213>  Homosapiens

<400>  513
actagcggag ccgcgaggga gaggccgcgg ccccttcccg ttgcctgcgg ccaccggccg     60

gcattcagag cccctcgcct ggcgctaaat ttaaaaacgt aacacgagca gcaggctggt    120

ctcggaaacg aaacgaaatt cggtccctgg gcctcctccc gggcgctgcc ggtccctcag    180

cgcgccgcgc cacccggaac agacccttct cccgccattt tcggcggggc tgggagactg    240

aggcccgcgg cgctgagcct gcggcgcccc ggaagaggcg ggcggcatgg ccgctggcgt    300

ggactgcggg gacggggttg gcgcccggca gcacgtgttc ctggtttcag aatatttaaa    360

agatgcttca aagaagatga aaaatgggct aatgtttgta aaactggtta acccctgttc    420

aggagaagga gccatttact tgttcaatat gtgtctacag cagctgcttg aagtaaaagt    480

tttcaaggaa aaacaccatt cttggtttat aaatcaatca gttcaatcag gaggtcttct    540

ccattttgcc acacctgtgg atcctctatt tctgcttctc cactacctca taaaggctga    600

taaggagggg aagtttcagc cccttgatca agttgtggtg gataacgtgt ttccaaattg    660

catcttgttg ctgaaacttc ctggacttga gaagttactt catcatgtga cagaggaaaa    720

aggtaatcca gaaatagaca acaagaaata ttacaagtac agcaaagaga agacattaaa    780

gtggctggaa aaaaaggtta atcaaactgt ggcagcatta aaaaccaata atgtgaatgt    840

cagttcccgg gtacagtcaa ctgcattttt ctctggtgac caagcttcca ctgacaagga    900

agaggattat attcgttatg cccatggtct gatatctgac tacatcccta aagaattaag    960

tgatgactta tctaaatact taaagcttcc agaaccttca gcctcattgc caaatcctcc   1020

atcaaagaaa ataaagttat cagatgagcc tgtagaagca aaagaagatt acactaagtt   1080

taatactaaa gatttgaaga ctgaaaagaa aaatagcaaa atgactgcag ctcagaaggc   1140

tttggctaaa gttgacaaga gtggaatgaa aagtattgat accttttttg gggtaaaaaa   1200

taaaaaaaaa attggaaagg tttgaaactt tgaaaataaa atctagcaaa aatatttgct   1260

ttttacatgt ttcagtttgt ccttcctgac tgttaatgac tacctttggt tgggggaagg   1320

aagaggccaa tttcatgttc tcttaaacat ttctttgcat ttggtttttg tgttcctgaa   1380

caaaatatgg gaaagtgtct aacttcatgg ctatggcctt ttggagtctc atctgacata   1440

atgaaaagta atcacttgaa gagaattaac atatagcatc atgattttct caataaactg   1500

atgtgtgaca atgtt                                                    1515


<210>  514
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  514

Met Ala Ala Gly Val Asp Cys Gly Asp Gly Val Gly Ala Arg Gln His 
1               5                   10                  15      


Val Phe Leu Val Ser Glu Tyr Leu Lys Asp Ala Ser Lys Lys Met Lys 
            20                  25                  30          


Asn Gly Leu Met Phe Val Lys Leu Val Asn Pro Cys Ser Gly Glu Gly 
        35                  40                  45              


Ala Ile Tyr Leu Phe Asn Met Cys Leu Gln Gln Leu Leu Glu Val Lys 
    50                  55                  60                  


Val Phe Lys Glu Lys His His Ser Trp Phe Ile Asn Gln Ser Val Gln 
65                  70                  75                  80  


Ser Gly Gly Leu Leu His Phe Ala Thr Pro Val Asp Pro Leu Phe Leu 
                85                  90                  95      


Leu Leu His Tyr Leu Ile Lys Ala Asp Lys Glu Gly Lys Phe Gln Pro 
            100                 105                 110         


Leu Asp Gln Val Val Val Asp Asn Val Phe Pro Asn Cys Ile Leu Leu 
        115                 120                 125             


Leu Lys Leu Pro Gly Leu Glu Lys Leu Leu His His Val Thr Glu Glu 
    130                 135                 140                 


Lys Gly Asn Pro Glu Ile Asp Asn Lys Lys Tyr Tyr Lys Tyr Ser Lys 
145                 150                 155                 160 


Glu Lys Thr Leu Lys Trp Leu Glu Lys Lys Val Asn Gln Thr Val Ala 
                165                 170                 175     


Ala Leu Lys Thr Asn Asn Val Asn Val Ser Ser Arg Val Gln Ser Thr 
            180                 185                 190         


Ala Phe Phe Ser Gly Asp Gln Ala Ser Thr Asp Lys Glu Glu Asp Tyr 
        195                 200                 205             


Ile Arg Tyr Ala His Gly Leu Ile Ser Asp Tyr Ile Pro Lys Glu Leu 
    210                 215                 220                 


Ser Asp Asp Leu Ser Lys Tyr Leu Lys Leu Pro Glu Pro Ser Ala Ser 
225                 230                 235                 240 


Leu Pro Asn Pro Pro Ser Lys Lys Ile Lys Leu Ser Asp Glu Pro Val 
                245                 250                 255     


Glu Ala Lys Glu Asp Tyr Thr Lys Phe Asn Thr Lys Asp Leu Lys Thr 
            260                 265                 270         


Glu Lys Lys Asn Ser Lys Met Thr Ala Ala Gln Lys Ala Leu Ala Lys 
        275                 280                 285             


Val Asp Lys Ser Gly Met Lys Ser Ile Asp Thr Phe Phe Gly Val Lys 
    290                 295                 300                 


Asn Lys Lys Lys Ile Gly Lys Val 
305                 310         


<210>  515
<211>  2874
<212>  DNA
<213>  Homosapiens

<400>  515
gcttggtgct gcatctcaat ccctgtggcc ccaggagcag ctgcggcagg aacatgtatg     60

gatttatcaa cacctgtctg caatctcttg tgatagagaa atttggtgaa gaaacatggg    120

aaaaattgaa aacttctgca gaagtacaag atgccttcat gacctacaca atgtatgatg    180

acgtcatcac cattaagctc atccaagagg cctgcaacat tctgggtgtc tccatggaag    240

ccatcctgaa actctttgga gaatactttc aattctgaag atgtctggct atgacaggat    300

gctacggaca ctgggaggaa atctcatgga gtttattgaa aacctggatg ccctccacag    360

ttacctggca ctctcttatc aggagatgaa tgcaccatcg tttcgtgtgg agagaggagc    420

agatgggaaa atgtttctcc attactactc ggatagaagt ggtctgtgcc acattgtacc    480

aggtatcatt gaggctgtgg ccaaagactt ctttgatatt gatgtaatca tggacattct    540

tgacatgaat gaagaagtgg agaggacagg gaagaaggag catgttgtgt ttctgattgt    600

acagaaggct cacaggaaga tgagaaagac aaagccaaaa aggttacaag acagtcaggg    660

catggagaga gaccaagagg ccctccaggc agctttcctc aagatgaagg agaaatattt    720

gaatgtctct gcttgtcctg tgaaaaaatc ccactgggat gttgtgagaa gcatagtcat    780

gtttggaaaa gggcatctca tgaacacctt tgagccaatt tatcctgaga gactctggat    840

tgaagagaag acattctgca acgcttttcc tttccacatt gtattcgatg aatcactaca    900

ggtgaagcaa gccagagtga acattcagaa gtacgtacca ggactccaaa cccagaatat    960

tcaactggat gagtatttct ccatcattca tcctcaagtt accttcaaca ttttcagcat   1020

ccgcagattt atcaacagtc aatttgtcct gaagacacga agagaaatga tgcctgtagc   1080

atggcaaagt cggactacac tcaaacttca aggccagatg atctggatgg agtccatgtg   1140

gtgcatggtg tacctgtgct ctccgaagct ccgcagcctg caagagctgg aagaactcaa   1200

tatgcatctt tctgacatcg cccccaacga caccaccagg gatctcatcc tcctgaacca   1260

gcagcggctg gctgagatag agctgtccaa ccagctggaa aggaagaagg aggagctaca   1320

ggtcctctcc aagcacttgg ccattgaaaa gaagaaaaca gagaccttac tttatgccat   1380

gctgcccaaa cacgtggcca accagctgag ggagggcaaa aaggtggctg caggagaatt   1440

taaaagctgc acgattcttt tcagcgatgt agtgacattt actaacatct gtactgcctg   1500

tgaacctata caaatagtga acgtgctgaa ttccatgtac tccaagtttg acagattaac   1560

cagtgtgcac gcagtctata aagtagaaac aataggagat gcttatatgg tggtaggagg   1620

tgtaccagtg cctattggaa accatgctca aagagtggct aattttgcct tggggatgag   1680

aatttctgca aaggaagtga cgaatcctgt tactggagaa cccatccagc tcagagtggg   1740

gatccatact ggaccagtct tagcagatgt tgtaggagac aagatgccac ggtactgctt   1800

gtttggtgac actgtgaaca cagcttctag gatggaaagt catgggcttc ccaacaaagt   1860

gcacctcagt cccacagcct acagagcctt gaaaaatcaa gggtttaaaa tcattgagag   1920

gggtgaaatt gaagtgaaag gtaaagggag aatgaccaca tactttttga tccagaactt   1980

gaatgccaca gaggatgaga tcatggggag atctaaaacc ccagttgatc acaaggggtc   2040

aacacagaaa gcatccttgc ccaccaccaa gctccagggc tcagttcaac catcttgccc   2100

tgaacactct tctcttgcat cctggttatt atgacgttct ttgagctggg ccgatagatc   2160

cagctgaaga gttctacata cattagtctt caaggttctt ctctgggcgt ttcccatgca   2220

gctctctggt agctggggaa tgatttgtaa tgagtacatg aaacacgtta aatgtccttc   2280

agcctcccta ccacgacatc caacagctgg aacttccatc cagtccttca catgatgggc   2340

acctgtggga aacctgccag gggcagccga tgttcagagg catccaaaaa aagtctccca   2400

cttcggcagc catgaagccc actcatgcaa ccgtcctcac ttttccttcc tctcacggtt   2460

ttttgcagaa gcaagtgctc agggaaatga agacaggaga actgctgccg tcatgagcta   2520

tgccgacagt cagcagctga tccccgacag aaacgcagca gatgcagacg ctcctgatga   2580

aatcatccct gtggggagtg cagggccaga tggggactcc atggagacag ccgaccggcg   2640

acagccttca gctccgacaa agacacatca ccttgcaaat gacactttgc cgtctggttt   2700

ctgtgttttg ttgtaacagg ttaaatgaac ccctgggctt aattttcccc ctacttagtt   2760

ctgtggcagc aaagaaaagt gacttctttt catttctcag ctcaaaactt cttaagccgt   2820

gtctcttcct catcatccct ttgagaataa aagtctagaa atgaaacaca aaaa         2874


<210>  516
<211>  617
<212>  PRT
<213>  Homosapiens

<400>  516

Met Ser Gly Tyr Asp Arg Met Leu Arg Thr Leu Gly Gly Asn Leu Met 
1               5                   10                  15      


Glu Phe Ile Glu Asn Leu Asp Ala Leu His Ser Tyr Leu Ala Leu Ser 
            20                  25                  30          


Tyr Gln Glu Met Asn Ala Pro Ser Phe Arg Val Glu Arg Gly Ala Asp 
        35                  40                  45              


Gly Lys Met Phe Leu His Tyr Tyr Ser Asp Arg Ser Gly Leu Cys His 
    50                  55                  60                  


Ile Val Pro Gly Ile Ile Glu Ala Val Ala Lys Asp Phe Phe Asp Ile 
65                  70                  75                  80  


Asp Val Ile Met Asp Ile Leu Asp Met Asn Glu Glu Val Glu Arg Thr 
                85                  90                  95      


Gly Lys Lys Glu His Val Val Phe Leu Ile Val Gln Lys Ala His Arg 
            100                 105                 110         


Lys Met Arg Lys Thr Lys Pro Lys Arg Leu Gln Asp Ser Gln Gly Met 
        115                 120                 125             


Glu Arg Asp Gln Glu Ala Leu Gln Ala Ala Phe Leu Lys Met Lys Glu 
    130                 135                 140                 


Lys Tyr Leu Asn Val Ser Ala Cys Pro Val Lys Lys Ser His Trp Asp 
145                 150                 155                 160 


Val Val Arg Ser Ile Val Met Phe Gly Lys Gly His Leu Met Asn Thr 
                165                 170                 175     


Phe Glu Pro Ile Tyr Pro Glu Arg Leu Trp Ile Glu Glu Lys Thr Phe 
            180                 185                 190         


Cys Asn Ala Phe Pro Phe His Ile Val Phe Asp Glu Ser Leu Gln Val 
        195                 200                 205             


Lys Gln Ala Arg Val Asn Ile Gln Lys Tyr Val Pro Gly Leu Gln Thr 
    210                 215                 220                 


Gln Asn Ile Gln Leu Asp Glu Tyr Phe Ser Ile Ile His Pro Gln Val 
225                 230                 235                 240 


Thr Phe Asn Ile Phe Ser Ile Arg Arg Phe Ile Asn Ser Gln Phe Val 
                245                 250                 255     


Leu Lys Thr Arg Arg Glu Met Met Pro Val Ala Trp Gln Ser Arg Thr 
            260                 265                 270         


Thr Leu Lys Leu Gln Gly Gln Met Ile Trp Met Glu Ser Met Trp Cys 
        275                 280                 285             


Met Val Tyr Leu Cys Ser Pro Lys Leu Arg Ser Leu Gln Glu Leu Glu 
    290                 295                 300                 


Glu Leu Asn Met His Leu Ser Asp Ile Ala Pro Asn Asp Thr Thr Arg 
305                 310                 315                 320 


Asp Leu Ile Leu Leu Asn Gln Gln Arg Leu Ala Glu Ile Glu Leu Ser 
                325                 330                 335     


Asn Gln Leu Glu Arg Lys Lys Glu Glu Leu Gln Val Leu Ser Lys His 
            340                 345                 350         


Leu Ala Ile Glu Lys Lys Lys Thr Glu Thr Leu Leu Tyr Ala Met Leu 
        355                 360                 365             


Pro Lys His Val Ala Asn Gln Leu Arg Glu Gly Lys Lys Val Ala Ala 
    370                 375                 380                 


Gly Glu Phe Lys Ser Cys Thr Ile Leu Phe Ser Asp Val Val Thr Phe 
385                 390                 395                 400 


Thr Asn Ile Cys Thr Ala Cys Glu Pro Ile Gln Ile Val Asn Val Leu 
                405                 410                 415     


Asn Ser Met Tyr Ser Lys Phe Asp Arg Leu Thr Ser Val His Ala Val 
            420                 425                 430         


Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Val Gly Gly Val 
        435                 440                 445             


Pro Val Pro Ile Gly Asn His Ala Gln Arg Val Ala Asn Phe Ala Leu 
    450                 455                 460                 


Gly Met Arg Ile Ser Ala Lys Glu Val Thr Asn Pro Val Thr Gly Glu 
465                 470                 475                 480 


Pro Ile Gln Leu Arg Val Gly Ile His Thr Gly Pro Val Leu Ala Asp 
                485                 490                 495     


Val Val Gly Asp Lys Met Pro Arg Tyr Cys Leu Phe Gly Asp Thr Val 
            500                 505                 510         


Asn Thr Ala Ser Arg Met Glu Ser His Gly Leu Pro Asn Lys Val His 
        515                 520                 525             


Leu Ser Pro Thr Ala Tyr Arg Ala Leu Lys Asn Gln Gly Phe Lys Ile 
    530                 535                 540                 


Ile Glu Arg Gly Glu Ile Glu Val Lys Gly Lys Gly Arg Met Thr Thr 
545                 550                 555                 560 


Tyr Phe Leu Ile Gln Asn Leu Asn Ala Thr Glu Asp Glu Ile Met Gly 
                565                 570                 575     


Arg Ser Lys Thr Pro Val Asp His Lys Gly Ser Thr Gln Lys Ala Ser 
            580                 585                 590         


Leu Pro Thr Thr Lys Leu Gln Gly Ser Val Gln Pro Ser Cys Pro Glu 
        595                 600                 605             


His Ser Ser Leu Ala Ser Trp Leu Leu 
    610                 615         


<210>  517
<211>  2104
<212>  DNA
<213>  Homosapiens

<400>  517
gagttgtttg ccggctcccg ggccgccaga cgctcggagg gagcccggcc ggctcggact     60

gggcggccgg gagggagggc gccccgggtc acgacggcgc ccgcaagccg agcgcggccg    120

ggacgtgcac catggaccca aaggcgggcg gcggcggcga ggaggacgac tgcgtggact    180

cgggcgccga gaccggaggg tccgactaca gccacctgtc ctccacgagc aatggattct    240

ccacctggcg gatgccatgt tgcctgttcc tttactgtac acacggtgac aaagaaaagg    300

gaagatggag cctccaggtt gaacatacct ggccctcagg tgagctttcc gttgaagagg    360

cgcaggaccc tttcctggtc agcatccaca taatcgcaga cccaggggag tcccagcccc    420

tgcaggaggc catcgacaac gtcctggcgt ggatccaccc cgacctcccg ctgttccggg    480

tgtccgagag gcgggcgtcc cggcggcggc ggaagccccc caagggcgct cagccagcgc    540

tggctgtggt gctgttcctg caggaggagt acggcgaaga gcagatcctg cagctgcacc    600

gcacactgca gcagccgccc tggcgccacc accacaccga gcaggtgcac ggccggttcc    660

tgccctacct gccctgcagc caggacttct tcacgctggc ccctgggacg ccgctttggg    720

ccatccggcc cgtgcactac ggcaaggaaa tcgtgcgctt caccgtctac tgtcgctacg    780

acaactatgc tgacagcctc aggttctacc agctgattct ccggaggaac cccagccaga    840

agaaagcgga cttctgcatc ttccctattt tttccaacct ggatgtggac atccagttct    900

ccctgaaaag actgccctgt gaccagtgcc cggtgcccac cgactcctcc gtgctggagt    960

tccgagtgag ggacataggc gagctcgtgc ctctcctgcc caacccttgc agccccatca   1020

gcgaggggcg ctggcagacg gaggaccatg atgggaacaa gatcctccta caggcacaaa   1080

gggtgcataa gaagtttcct aaacctggca gagtacatca tgcctccgag aagaaacgtc   1140

attccactcc tttgccgagc actgctgtac caagccatac acctggcagc agccagcagt   1200

ccccgctcaa cagtcctcac ccggggccca tccggacagg cctgcctcct gggcaccagc   1260

aggaatttgc cggacgagcc aacagcaccc ccaaccctcc ctggtctttc cagagaagca   1320

agtccttgtt ttgtttgccc acgggaggcc cctccctggc ctcctcagct gaaccacagt   1380

ggttttcaaa cacaggtgcc ccagggcaca gggcatcaga gtggaggcat ggccacctcc   1440

tctccatcga tgacctagag ggggcccagg agacagacgt ggacacaggc ctgcggctgt   1500

cctcatcgga cctgtctgtg gtctctgcat attctgcacc cagtaggttc tgcagcacag   1560

tggagacacc cctcccctcc gaaagatgca gcagccactg ggcagctcac aaggattcca   1620

gggagggacc actgcccact gtcagcaggg tgaccacaga ggcctcctgg gcttccctcc   1680

ctttcttcac caaaaggtct tccagctcct cagcgacagc tcgtgctgct cccccagctc   1740

ccagcacctc caccctcaca gactcctccc cacagctccc atgcgatacc cccaaagtca   1800

agcagactga tggagacatg ccaccacccc cagggtcggc tggccccggg gataacgaca   1860

tggaggaatt ctacatctga atgccctctg ctcttgttct cgaaacacac aaactcagag   1920

acacagactc aggccccact gcccctctgg ccactgagca caccacattc ttcatgatcc   1980

atttcccagg agcccgtagc acatttgcct accacccact cttagctggg gggtggtata   2040

tctctagaga cacagcagaa aaatactggc atttttatgc aaataaattc tcaacaaact   2100

tgtc                                                                2104


<210>  518
<211>  582
<212>  PRT
<213>  Homosapiens

<400>  518

Met Asp Pro Lys Ala Gly Gly Gly Gly Glu Glu Asp Asp Cys Val Asp 
1               5                   10                  15      


Ser Gly Ala Glu Thr Gly Gly Ser Asp Tyr Ser His Leu Ser Ser Thr 
            20                  25                  30          


Ser Asn Gly Phe Ser Thr Trp Arg Met Pro Cys Cys Leu Phe Leu Tyr 
        35                  40                  45              


Cys Thr His Gly Asp Lys Glu Lys Gly Arg Trp Ser Leu Gln Val Glu 
    50                  55                  60                  


His Thr Trp Pro Ser Gly Glu Leu Ser Val Glu Glu Ala Gln Asp Pro 
65                  70                  75                  80  


Phe Leu Val Ser Ile His Ile Ile Ala Asp Pro Gly Glu Ser Gln Pro 
                85                  90                  95      


Leu Gln Glu Ala Ile Asp Asn Val Leu Ala Trp Ile His Pro Asp Leu 
            100                 105                 110         


Pro Leu Phe Arg Val Ser Glu Arg Arg Ala Ser Arg Arg Arg Arg Lys 
        115                 120                 125             


Pro Pro Lys Gly Ala Gln Pro Ala Leu Ala Val Val Leu Phe Leu Gln 
    130                 135                 140                 


Glu Glu Tyr Gly Glu Glu Gln Ile Leu Gln Leu His Arg Thr Leu Gln 
145                 150                 155                 160 


Gln Pro Pro Trp Arg His His His Thr Glu Gln Val His Gly Arg Phe 
                165                 170                 175     


Leu Pro Tyr Leu Pro Cys Ser Gln Asp Phe Phe Thr Leu Ala Pro Gly 
            180                 185                 190         


Thr Pro Leu Trp Ala Ile Arg Pro Val His Tyr Gly Lys Glu Ile Val 
        195                 200                 205             


Arg Phe Thr Val Tyr Cys Arg Tyr Asp Asn Tyr Ala Asp Ser Leu Arg 
    210                 215                 220                 


Phe Tyr Gln Leu Ile Leu Arg Arg Asn Pro Ser Gln Lys Lys Ala Asp 
225                 230                 235                 240 


Phe Cys Ile Phe Pro Ile Phe Ser Asn Leu Asp Val Asp Ile Gln Phe 
                245                 250                 255     


Ser Leu Lys Arg Leu Pro Cys Asp Gln Cys Pro Val Pro Thr Asp Ser 
            260                 265                 270         


Ser Val Leu Glu Phe Arg Val Arg Asp Ile Gly Glu Leu Val Pro Leu 
        275                 280                 285             


Leu Pro Asn Pro Cys Ser Pro Ile Ser Glu Gly Arg Trp Gln Thr Glu 
    290                 295                 300                 


Asp His Asp Gly Asn Lys Ile Leu Leu Gln Ala Gln Arg Val His Lys 
305                 310                 315                 320 


Lys Phe Pro Lys Pro Gly Arg Val His His Ala Ser Glu Lys Lys Arg 
                325                 330                 335     


His Ser Thr Pro Leu Pro Ser Thr Ala Val Pro Ser His Thr Pro Gly 
            340                 345                 350         


Ser Ser Gln Gln Ser Pro Leu Asn Ser Pro His Pro Gly Pro Ile Arg 
        355                 360                 365             


Thr Gly Leu Pro Pro Gly His Gln Gln Glu Phe Ala Gly Arg Ala Asn 
    370                 375                 380                 


Ser Thr Pro Asn Pro Pro Trp Ser Phe Gln Arg Ser Lys Ser Leu Phe 
385                 390                 395                 400 


Cys Leu Pro Thr Gly Gly Pro Ser Leu Ala Ser Ser Ala Glu Pro Gln 
                405                 410                 415     


Trp Phe Ser Asn Thr Gly Ala Pro Gly His Arg Ala Ser Glu Trp Arg 
            420                 425                 430         


His Gly His Leu Leu Ser Ile Asp Asp Leu Glu Gly Ala Gln Glu Thr 
        435                 440                 445             


Asp Val Asp Thr Gly Leu Arg Leu Ser Ser Ser Asp Leu Ser Val Val 
    450                 455                 460                 


Ser Ala Tyr Ser Ala Pro Ser Arg Phe Cys Ser Thr Val Glu Thr Pro 
465                 470                 475                 480 


Leu Pro Ser Glu Arg Cys Ser Ser His Trp Ala Ala His Lys Asp Ser 
                485                 490                 495     


Arg Glu Gly Pro Leu Pro Thr Val Ser Arg Val Thr Thr Glu Ala Ser 
            500                 505                 510         


Trp Ala Ser Leu Pro Phe Phe Thr Lys Arg Ser Ser Ser Ser Ser Ala 
        515                 520                 525             


Thr Ala Arg Ala Ala Pro Pro Ala Pro Ser Thr Ser Thr Leu Thr Asp 
    530                 535                 540                 


Ser Ser Pro Gln Leu Pro Cys Asp Thr Pro Lys Val Lys Gln Thr Asp 
545                 550                 555                 560 


Gly Asp Met Pro Pro Pro Pro Gly Ser Ala Gly Pro Gly Asp Asn Asp 
                565                 570                 575     


Met Glu Glu Phe Tyr Ile 
            580         


<210>  519
<211>  2844
<212>  DNA
<213>  Homosapiens

<400>  519
atgaggcccg gcctctcatt tctcctagcc cttctgttct tccttggcca agctgcaggg     60

gatttggggg atgtgggacc tccaattccc agccccggct tcagctcttt cccaggtgtt    120

gactccagct ccagcttcag ctccagctcc aggtcgggct ccagctccag ccgcagctta    180

ggcagcggag gttctgtgtc ccagttgttt tccaatttca ccggctccgt ggatgaccgt    240

gggacctgcc agtgctctgt ttccctgcca gacaccacct ttcccgtgga cagagtggaa    300

cgcttggaat tcacagctca tgttctttct cagaagtttg agaaagaact ttccaaagtg    360

agggaatatg tccaattaat tagtgtgtat gaaaagaaac tgttaaacct aactgtccga    420

attgacatca tggagaagga taccatttct tacactgaac tggacttcga gctgatcaag    480

gtagaagtga aggagatgga aaaactggtc atacagctga aggagagttt tggtggaagc    540

tcagaaattg ttgaccagct ggaggtggag ataagaaata tgactctctt ggtagagaag    600

cttgagacac tagacaaaaa caatgtcctt gccattcgcc gagaaatcgt ggctctgaag    660

accaagctga aagagtgtga ggcctctaaa gatcaaaaca cccctgtcgt ccaccctcct    720

cccactccag ggagctgtgg tcatggtggt gtggtgaaca tcagcaaacc gtctgtggtt    780

cagctcaact ggagagggtt ttcttatcta tatggtgctt ggggtaggga ttactctccc    840

cagcatccaa acaaaggact gtattgggtg gcgccattga atacagatgg gagactgttg    900

gagtattata gactgtacaa cacactggat gatttgctat tgtatataaa tgctcgagag    960

ttgcggatca cctatggcca aggtagtggt acagcagttt acaacaacaa catgtacgtc   1020

aacatgtaca acaccgggaa tattgccaga gttaacctga ccaccaacac gattgctgtg   1080

actcaaactc tccctaatgc tgcctataat aaccgctttt catatgctaa tgttgcttgg   1140

caagatattg actttgctgt ggatgagaat ggattgtggg ttatttattc aactgaagcc   1200

agcactggta acatggtgat tagtaaactc aatgacacca cacttcaggt gctaaacact   1260

tggtatacca agcagtataa accatctgct tctaacgcct tcatggtatg tggggttctg   1320

tatgccaccc gtactatgaa caccagaaca gaagagattt tttactatta tgacacaaac   1380

acagggaaag agggcaaact agacattgta atgcataaga tgcaggaaaa agtgcagagc   1440

attaactata acccttttga ccagaaactt tatgtctata acgatggtta ccttctgaat   1500

tatgatcttt ctgtcttgca gaagccccag taagctgttt aggagttagg gtgaaagaga   1560

aaatgtttgt tgaaaaaata gtcttctcca cttacttaga tatctgcagg ggtgtctaaa   1620

agtgtgttca ttttgcagca atgtttaggt gcatagttct accacactag agatctagga   1680

catttgtctt gatttggtga gttctcttgg gaatcatctg cctcttcagg cgcattttgc   1740

aataaagtct gtctagggtg ggattgtcag aggtctaggg gcactgtggg cctagtgaag   1800

cctactgtga ggaggcttca ctagaagcct taaattagga attaaggaac ttaaaactca   1860

gtatggcgtc tagggattct ttgtacagga aatattgccc aatgactagt cctcatccat   1920

gtagcaccac taattcttcc atgcctggaa gaaacctggg gacttagtta ggtagattaa   1980

tatctggagc tcctcgaggg accaaatctc caactttttt ttcccctcac tagcacctgg   2040

aatgatgctt tgtatgtggc agataagtaa atttggcatg cttatatatt ctacatctgt   2100

aaagtgctga gttttatgga gagaggcctt tttatgcatt aaattgtaca tggcaaataa   2160

atcccagaag gatctgtaga tgaggcacct gctttttctt ttctctcatt gtccacctta   2220

ctaaaagtca gtagaatctt ctacctcata acttccttcc aaaggcagct cagaagatta   2280

gaaccagact tactaaccaa ttccaccccc caccaacccc cttctactgc ctactttaaa   2340

aaaattaata gttttctatg gaactgatct aagattagaa aaattaattt tctttaattt   2400

cattatgaac ttttatttac atgactctaa gactataaga aaatctgatg gcagtgacaa   2460

agtgctagca tttattgtta tctaataaag accttggagc atatgtgcaa cttatgagtg   2520

tatcagttgt tgcatgtaat ttttgccttt gtttaagcct ggaacttgta agaaaatgaa   2580

aatttaattt ttttttctag gacgagctat agaaaagcta ttgagagtat ctagttaatc   2640

agtgcagtag ttggaaacct tgctggtgta tgtgatgtgc ttctgtgctt ttgaatgact   2700

ttatcatcta gtctttgtct atttttcctt tgatgttcaa gtcctagtct ataggattgg   2760

cagtttaaat gctttactcc cccttttaaa ataaatgatt aaaatgtgct ttgaaaaaaa   2820

aaaaaaaaaa aaaaaaaaaa aaaa                                          2844


<210>  520
<211>  510
<212>  PRT
<213>  Homosapiens

<400>  520

Met Arg Pro Gly Leu Ser Phe Leu Leu Ala Leu Leu Phe Phe Leu Gly 
1               5                   10                  15      


Gln Ala Ala Gly Asp Leu Gly Asp Val Gly Pro Pro Ile Pro Ser Pro 
            20                  25                  30          


Gly Phe Ser Ser Phe Pro Gly Val Asp Ser Ser Ser Ser Phe Ser Ser 
        35                  40                  45              


Ser Ser Arg Ser Gly Ser Ser Ser Ser Arg Ser Leu Gly Ser Gly Gly 
    50                  55                  60                  


Ser Val Ser Gln Leu Phe Ser Asn Phe Thr Gly Ser Val Asp Asp Arg 
65                  70                  75                  80  


Gly Thr Cys Gln Cys Ser Val Ser Leu Pro Asp Thr Thr Phe Pro Val 
                85                  90                  95      


Asp Arg Val Glu Arg Leu Glu Phe Thr Ala His Val Leu Ser Gln Lys 
            100                 105                 110         


Phe Glu Lys Glu Leu Ser Lys Val Arg Glu Tyr Val Gln Leu Ile Ser 
        115                 120                 125             


Val Tyr Glu Lys Lys Leu Leu Asn Leu Thr Val Arg Ile Asp Ile Met 
    130                 135                 140                 


Glu Lys Asp Thr Ile Ser Tyr Thr Glu Leu Asp Phe Glu Leu Ile Lys 
145                 150                 155                 160 


Val Glu Val Lys Glu Met Glu Lys Leu Val Ile Gln Leu Lys Glu Ser 
                165                 170                 175     


Phe Gly Gly Ser Ser Glu Ile Val Asp Gln Leu Glu Val Glu Ile Arg 
            180                 185                 190         


Asn Met Thr Leu Leu Val Glu Lys Leu Glu Thr Leu Asp Lys Asn Asn 
        195                 200                 205             


Val Leu Ala Ile Arg Arg Glu Ile Val Ala Leu Lys Thr Lys Leu Lys 
    210                 215                 220                 


Glu Cys Glu Ala Ser Lys Asp Gln Asn Thr Pro Val Val His Pro Pro 
225                 230                 235                 240 


Pro Thr Pro Gly Ser Cys Gly His Gly Gly Val Val Asn Ile Ser Lys 
                245                 250                 255     


Pro Ser Val Val Gln Leu Asn Trp Arg Gly Phe Ser Tyr Leu Tyr Gly 
            260                 265                 270         


Ala Trp Gly Arg Asp Tyr Ser Pro Gln His Pro Asn Lys Gly Leu Tyr 
        275                 280                 285             


Trp Val Ala Pro Leu Asn Thr Asp Gly Arg Leu Leu Glu Tyr Tyr Arg 
    290                 295                 300                 


Leu Tyr Asn Thr Leu Asp Asp Leu Leu Leu Tyr Ile Asn Ala Arg Glu 
305                 310                 315                 320 


Leu Arg Ile Thr Tyr Gly Gln Gly Ser Gly Thr Ala Val Tyr Asn Asn 
                325                 330                 335     


Asn Met Tyr Val Asn Met Tyr Asn Thr Gly Asn Ile Ala Arg Val Asn 
            340                 345                 350         


Leu Thr Thr Asn Thr Ile Ala Val Thr Gln Thr Leu Pro Asn Ala Ala 
        355                 360                 365             


Tyr Asn Asn Arg Phe Ser Tyr Ala Asn Val Ala Trp Gln Asp Ile Asp 
    370                 375                 380                 


Phe Ala Val Asp Glu Asn Gly Leu Trp Val Ile Tyr Ser Thr Glu Ala 
385                 390                 395                 400 


Ser Thr Gly Asn Met Val Ile Ser Lys Leu Asn Asp Thr Thr Leu Gln 
                405                 410                 415     


Val Leu Asn Thr Trp Tyr Thr Lys Gln Tyr Lys Pro Ser Ala Ser Asn 
            420                 425                 430         


Ala Phe Met Val Cys Gly Val Leu Tyr Ala Thr Arg Thr Met Asn Thr 
        435                 440                 445             


Arg Thr Glu Glu Ile Phe Tyr Tyr Tyr Asp Thr Asn Thr Gly Lys Glu 
    450                 455                 460                 


Gly Lys Leu Asp Ile Val Met His Lys Met Gln Glu Lys Val Gln Ser 
465                 470                 475                 480 


Ile Asn Tyr Asn Pro Phe Asp Gln Lys Leu Tyr Val Tyr Asn Asp Gly 
                485                 490                 495     


Tyr Leu Leu Asn Tyr Asp Leu Ser Val Leu Gln Lys Pro Gln 
            500                 505                 510 


<210>  521
<211>  2681
<212>  DNA
<213>  Homosapiens

<400>  521
tggtatggca gaatacagaa aatgctttat tggagacagt cattgtatca acagtacact     60

tgatctccag tacagacata tggtggaaca gaagcctgga tacaggactc agactcttac    120

tggttggtat catacgtgat cgtttgtttc agttcatctc taaattgcag tttgccgtga    180

ctgtgctttt gacatcatgg acacaggaaa aacaacgtcg aaaaacaact gccactttat    240

gtatactcaa cattgtcttt tctccattcg tgttggtcat catagttttt tctacactac    300

tctcttctcc cttactccct cttttcaccc ttcctgtgtt cttggtgggg tttccccgac    360

ctattcagag ttggccagga gcagcaggca ccacagcctg tgtgtgtgca gatacagtgt    420

actactacca aatggtgccc aggttgactg ctgtactgca gactgcaatg gcagctggaa    480

gtttaggtct cctcctacct ggatctcatt acttgggccg ttttcaggat cgtttaatgt    540

ggataatgat tctggaatgt ggctatactt actgctctat taacattaag gggttagaat    600

tgcaggaaac atcctgtcat actgcagaag ctcgcagagt tgatgaagtt tttgaagatg    660

cttttgagca agaatacaca agagtatgtt cccttaatga acactttgga aatgtcttga    720

caccctgtac tgttttgcct gtgaaattgt attctgatgc caggaatgtt ctatcaggca    780

taattgattc tcatgaaaac ttaaaagaat ttaaaggtga cctcattaaa gtacttgtgt    840

ggatacttgt tcaatactgc tccaaaaggc ctggcatgaa agagaatgtt cacaacactg    900

aaaataaagg gaaagcacct ctaatgttgc ctgctttgaa cactttgcca cctcccaaat    960

ccccagaaga catagacagt ttaaattcag aaacttttaa tgactggtct gatgataata   1020

tttttgatga tgagccaact atcaaaaaag taatagaaga aaaacatcag ttgaaagatt   1080

tgccaggtac aaatttgttt attccaggat cagtagaatc acagagggtt ggtgatcatt   1140

ctacaggcac tgttcctgaa aacgatcttt acaaagcagt tctattagga taccctgctg   1200

ttgacaaagg aaaacaagag gacatgccat atattcctct catggagttc agttgttcac   1260

attctcactt agtatgctta cccgcagagt ggaggactag ctgtatgccc agttccaaaa   1320

tgaaggagat gagctcgtta tttccagaag actggtacca atttgttcta aggcagttgg   1380

aatgttatca ttcagaagag aaggcctcaa atgtactgga agaaattgcc aaggacaaag   1440

ttttaaaaga cttttatgtt catacagtaa tgacttgtta tttcagttta tttggaatag   1500

acaatatggc tcctagtcct ggtcatatat tgagagttta cagtggtgtt ttgccttggt   1560

ctgttgcttt ggactggctc acagaaaagc cagaactgtt tcaactagca ctgaaagcat   1620

tcaggtatac tctgaaacta atgattgata aagcaagttt aggtccaata gaagacttta   1680

gagaactgat taagtacctt gaagaatatg aacgtgactg gtacattggt ttggtatctg   1740

atgaaaagtg gaaggaagca attttacaag aaaagccata cttgttttct ctggggtatg   1800

attctaatat gggaatttac actgggagag tgcttagcct tcaagaatta ttgatccaag   1860

tgggaaagtt aaatcctgaa gctgttagag gtcagtgggc caatctttca tgggaattac   1920

tttatgccac aaacgatgat gaagaacgtt atagtataca agctcatcca ctacttttaa   1980

gaaatcttac ggtacaagca gcagaacctc ccctgggata tccgatttat tcttcaaaac   2040

ctctccacat acatttgtat tagagctcat tttgactgta atgtcatcaa atgcaatgtt   2100

tttatttttt catcctaaaa aagtaactgt gattcttgta acttgaggac ttctccacac   2160

ccccattcag atgcctgaga acagctaagc tccgtaaagt tggttctctt agccatctta   2220

atggttctaa aaaaacagca aaaacatctt tatgtctaag ataaaagaac tatttggcca   2280

atatttgtgc cctctggact ttagtaggct ttggtaaatg tgagaaaact tttgtagaat   2340

tattatataa tgaattttgt aatgctttct taaatgtgtt ataggtgaat tgccatacaa   2400

agttaacagc tatgtaattt ttacatactt aaaagataaa catatcagtg ttctaagtag   2460

tgataatgga tcctgttgaa ggttaacata atgtgtatat atttgtttga aatataattt   2520

atagtatttt caaatgtgct gatttatttt gacatctaat atctgaatgt ttttgtatca   2580

agtagtttgt tttcatagac ttcaattcat aaactttaaa aaacttttaa taaaatattt   2640

tccttccttt tcaaaaaaaa gaaaaaaaaa aaaaaaaaac a                       2681


<210>  522
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  522

Met Val Pro Arg Leu Thr Ala Val Leu Gln Thr Ala Met Ala Ala Gly 
1               5                   10                  15      


Ser Leu Gly Leu Leu Leu Pro Gly Ser His Tyr Leu Gly Arg Phe Gln 
            20                  25                  30          


Asp Arg Leu Met Trp Ile Met Ile Leu Glu Cys Gly Tyr Thr Tyr Cys 
        35                  40                  45              


Ser Ile Asn Ile Lys Gly Leu Glu Leu Gln Glu Thr Ser Cys His Thr 
    50                  55                  60                  


Ala Glu Ala Arg Arg Val Asp Glu Val Phe Glu Asp Ala Phe Glu Gln 
65                  70                  75                  80  


Glu Tyr Thr Arg Val Cys Ser Leu Asn Glu His Phe Gly Asn Val Leu 
                85                  90                  95      


Thr Pro Cys Thr Val Leu Pro Val Lys Leu Tyr Ser Asp Ala Arg Asn 
            100                 105                 110         


Val Leu Ser Gly Ile Ile Asp Ser His Glu Asn Leu Lys Glu Phe Lys 
        115                 120                 125             


Gly Asp Leu Ile Lys Val Leu Val Trp Ile Leu Val Gln Tyr Cys Ser 
    130                 135                 140                 


Lys Arg Pro Gly Met Lys Glu Asn Val His Asn Thr Glu Asn Lys Gly 
145                 150                 155                 160 


Lys Ala Pro Leu Met Leu Pro Ala Leu Asn Thr Leu Pro Pro Pro Lys 
                165                 170                 175     


Ser Pro Glu Asp Ile Asp Ser Leu Asn Ser Glu Thr Phe Asn Asp Trp 
            180                 185                 190         


Ser Asp Asp Asn Ile Phe Asp Asp Glu Pro Thr Ile Lys Lys Val Ile 
        195                 200                 205             


Glu Glu Lys His Gln Leu Lys Asp Leu Pro Gly Thr Asn Leu Phe Ile 
    210                 215                 220                 


Pro Gly Ser Val Glu Ser Gln Arg Val Gly Asp His Ser Thr Gly Thr 
225                 230                 235                 240 


Val Pro Glu Asn Asp Leu Tyr Lys Ala Val Leu Leu Gly Tyr Pro Ala 
                245                 250                 255     


Val Asp Lys Gly Lys Gln Glu Asp Met Pro Tyr Ile Pro Leu Met Glu 
            260                 265                 270         


Phe Ser Cys Ser His Ser His Leu Val Cys Leu Pro Ala Glu Trp Arg 
        275                 280                 285             


Thr Ser Cys Met Pro Ser Ser Lys Met Lys Glu Met Ser Ser Leu Phe 
    290                 295                 300                 


Pro Glu Asp Trp Tyr Gln Phe Val Leu Arg Gln Leu Glu Cys Tyr His 
305                 310                 315                 320 


Ser Glu Glu Lys Ala Ser Asn Val Leu Glu Glu Ile Ala Lys Asp Lys 
                325                 330                 335     


Val Leu Lys Asp Phe Tyr Val His Thr Val Met Thr Cys Tyr Phe Ser 
            340                 345                 350         


Leu Phe Gly Ile Asp Asn Met Ala Pro Ser Pro Gly His Ile Leu Arg 
        355                 360                 365             


Val Tyr Ser Gly Val Leu Pro Trp Ser Val Ala Leu Asp Trp Leu Thr 
    370                 375                 380                 


Glu Lys Pro Glu Leu Phe Gln Leu Ala Leu Lys Ala Phe Arg Tyr Thr 
385                 390                 395                 400 


Leu Lys Leu Met Ile Asp Lys Ala Ser Leu Gly Pro Ile Glu Asp Phe 
                405                 410                 415     


Arg Glu Leu Ile Lys Tyr Leu Glu Glu Tyr Glu Arg Asp Trp Tyr Ile 
            420                 425                 430         


Gly Leu Val Ser Asp Glu Lys Trp Lys Glu Ala Ile Leu Gln Glu Lys 
        435                 440                 445             


Pro Tyr Leu Phe Ser Leu Gly Tyr Asp Ser Asn Met Gly Ile Tyr Thr 
    450                 455                 460                 


Gly Arg Val Leu Ser Leu Gln Glu Leu Leu Ile Gln Val Gly Lys Leu 
465                 470                 475                 480 


Asn Pro Glu Ala Val Arg Gly Gln Trp Ala Asn Leu Ser Trp Glu Leu 
                485                 490                 495     


Leu Tyr Ala Thr Asn Asp Asp Glu Glu Arg Tyr Ser Ile Gln Ala His 
            500                 505                 510         


Pro Leu Leu Leu Arg Asn Leu Thr Val Gln Ala Ala Glu Pro Pro Leu 
        515                 520                 525             


Gly Tyr Pro Ile Tyr Ser Ser Lys Pro Leu His Ile His Leu Tyr 
    530                 535                 540             


<210>  523
<211>  1282
<212>  DNA
<213>  Homosapiens

<400>  523
ctgcgatccc gcagggcagc gacgcgactc tggtgcgggc cgtcttcttc cccccgagct     60

gggcgtgcgc ggccgcaatg aactgggagc tgctgctgtg gctgctggtg ctgtgcgcgc    120

tgctcctgct cttggtgcag ctgctgcgct tcctgagggc tgacggcgac ctgacgctac    180

tatgggccga gtggcaggga cgacgcccag aatgggagct gactgatatg gtggtgtggg    240

tgactggagc ctcgagtgga attggtgagg agctggctta ccagttgtct aaactaggag    300

tttctcttgt gctgtcagcc agaagagtgc atgagctgga aagggtgaaa agaagatgcc    360

tagagaatgg caatttaaaa gaaaaagata tacttgtttt gccccttgac ctgaccgaca    420

ctggttccca tgaagcggct accaaagctg ttctccagga gtttggtaga atcgacattc    480

tggtcaacaa tggtggaatg tcccagcgtt ctctgtgcat ggataccagc ttggatgtct    540

acagaaagct aatagagctt aactacttag ggacggtgtc cttgacaaaa tgtgttctgc    600

ctcacatgat cgagaggaag caaggaaaga ttgttactgt gaatagcatc ctgggtatca    660

tatctgtacc tctttccatt ggatactgtg ctagcaagca tgctctccgg ggttttttta    720

atggccttcg aacagaactt gccacatacc caggtataat agtttctaac atttgcccag    780

gacctgtgca atcaaatatt gtggagaatt ccctagctgg agaagtcaca aagactatag    840

gcaataatgg agaccagtcc cacaagatga caaccagtcg ttgtgtgcgg ctgatgttaa    900

tcagcatggc caatgatttg aaagaagttt ggatctcaga acaacctttc ttgttagtaa    960

catatttgtg gcaatacatg ccaacctggg cctggtggat aaccaacaag atggggaaga   1020

aaaggattga gaactttaag agtggtgtgg atgcagactc ttcttatttt aaaatcttta   1080

agacaaaaca tgactgaaaa gagcacctgt acttttcaag ccactggagg gagaaatgga   1140

aaacatgaaa acagcaatct tcttatgctt ctgaataatc aaagactaat ttgtgatttt   1200

actttttaat agatatgact ttgcttccaa catggaatga aataaaaaat aaataataaa   1260

agattgccat gaatcttgca aa                                            1282


<210>  524
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  524

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg 
    130                 135                 140                 


Ser Leu Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu 
145                 150                 155                 160 


Leu Asn Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His 
                165                 170                 175     


Met Ile Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu 
            180                 185                 190         


Gly Ile Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His 
        195                 200                 205             


Ala Leu Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    210                 215                 220                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
225                 230                 235                 240 


Ile Val Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn 
                245                 250                 255     


Asn Gly Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu 
            260                 265                 270         


Met Leu Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu 
        275                 280                 285             


Gln Pro Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp 
    290                 295                 300                 


Ala Trp Trp Ile Thr Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe 
305                 310                 315                 320 


Lys Ser Gly Val Asp Ala Asp Ser Ser Tyr Phe Lys Ile Phe Lys Thr 
                325                 330                 335     


Lys His Asp 
            


<210>  525
<211>  2409
<212>  DNA
<213>  Homosapiens

<400>  525
gtggttgggg aggggggggt ggggggactc tagacagctg aggcgcgaaa gcgatgagtc     60

ctcggctctt cctcctcctt ctccgggacc cgctctctgc ctccctctcc aacgcccgga    120

tgatctgagc cgcgagggcg ccgacagccg ggggcccgga cgcagcccgg ctcctcccct    180

cctccgcccc ttccccagcc tgacctggcc cgccgctgca gcggtgaccc ctcccccggc    240

tgccgccgtc gccgccgcgg tgaccccctc cccggctgcc gccgccgccg cctcggccga    300

ccagggacct gcccgcctgc ggctgctccg gacctagagg atcaagacat aatgggagca    360

tttttagaca agccaaagat ggaaaagcat aatgcccagg ggcagggtaa tgggttgcga    420

tatgggctaa gcagcatgca aggctggcgt gttgaaatgg aggatgcaca tacggctgtg    480

atcggtttgc caagtggact tgaatcgtgg tcattctttg ctgtgtatga tgggcatgct    540

ggttctcagg ttgccaaata ctgctgtgag catttgttag atcacatcac caataaccag    600

gattttaaag ggtctgcagg agcaccttct gtggaaaatg taaagaatgg aatcagaaca    660

ggttttctgg agattgatga acacatgaga gttatgtcag agaagaaaca tggtgcagat    720

agaagtgggt caacagctgt aggtgtctta atttctcccc aacatactta tttcattaac    780

tgtggagact caagaggttt actttgtagg aacaggaaag ttcatttctt cacacaagat    840

cacaaaccaa gtaatccgct ggagaaagaa cgaattcaga atgcaggtgg ctctgtaatg    900

attcagcgtg tgaatggctc tctggctgta tcgagggccc ttggggattt tgattacaaa    960

tgtgtccatg gaaaaggtcc tactgagcag cttgtctcac cagagcctga agtccatgat   1020

attgaaagat ctgaagaaga tgatcagttc attatccttg catgtgatgg tatctgggat   1080

gttatgggaa atgaagagct ctgtgatttt gtaagatcca gacttgaagt cactgatgac   1140

cttgagaaag tttgcaatga agtagtcgac acctgtttgt ataagggaag tcgagacaac   1200

atgagtgtga ttttgatctg ttttccaaat gcacccaaag tatcgccaga agcagtgaag   1260

aaggaggcag agttggacaa gtacctggaa tgcagagtag aagaaatcat aaagaagcag   1320

ggggaaggcg tccccgactt agtccatgtg atgcgcacat tagcgagtga gaacatcccc   1380

agcctcccac cagggggtga attggcaagc aagaggaatg ttattgaagc cgtttacaat   1440

agactgaatc cttacaaaaa tgacgacact gactctacat caacagatga tatgtggtaa   1500

aactgctcat ctagccatgg agtttacctt cacctccaaa ggagagtaca gctcaacttt   1560

gttgaaactt ttaacatcca tcctcaactt taaggaaggg gatatgacat gggtgagaat   1620

gattacatca gagaacttca gcagtacaac agctagccca gaactgattt tttttttttt   1680

ttttgtaaat ttgagactta tgtaagcgtg atttcaaacc ataattcgtg ttgtaaatca   1740

gactccagca atttttgttg tatgattttg tttttttgta aagtgtaatt gtccttgtac   1800

aaaatgctca tatttaatta tgaactgctt taaatcacta tcaaagttac aagaaatgtt   1860

tggcttattg tgtgatgcaa cagatatata gccctttcaa gtcatgttgt gtttggactt   1920

ggggttggaa cagggagagc agcagccatg tcagctacac gctcaaatgt gcagatgatt   1980

atggaaaata acctcaaaat cttacaaagc tgaacatcca aggagttatt gaaaactatc   2040

ttaaatgttc ttggtagggg agttggcatt gttgataaag ccagtccctt catttaactg   2100

tctttcagga tgttccttcg ttgtttccat gagtattgca ggtaataata cagtgtattc   2160

ataagaatct caatcttggg gctaaatgcc ttgtttcttt gcacctcttt tcaagtcctt   2220

acatttaatt actaattgat aagcagcagc ttcctacata tagtaggaaa ctgccacatt   2280

tttgctatca tgattggctg ggcctgctgc tgttcctagt aagatattct gaattccatt   2340

ttatcaataa agcttgattt aacaaacaag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2400

aaaaaaaaa                                                           2409


<210>  526
<211>  382
<212>  PRT
<213>  Homosapiens

<400>  526

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
1               5                   10                  15      


Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
            20                  25                  30          


Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
        35                  40                  45              


Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
    50                  55                  60                  


Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
65                  70                  75                  80  


Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                85                  90                  95      


Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
            100                 105                 110         


Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
        115                 120                 125             


Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
    130                 135                 140                 


Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
145                 150                 155                 160 


Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                165                 170                 175     


Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
            180                 185                 190         


Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
        195                 200                 205             


Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
    210                 215                 220                 


Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
225                 230                 235                 240 


Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                245                 250                 255     


Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
            260                 265                 270         


Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
        275                 280                 285             


Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
    290                 295                 300                 


Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Glu Ile Ile 
305                 310                 315                 320 


Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                325                 330                 335     


Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
            340                 345                 350         


Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
        355                 360                 365             


Lys Asn Asp Asp Thr Asp Ser Thr Ser Thr Asp Asp Met Trp 
    370                 375                 380         


<210>  527
<211>  2373
<212>  DNA
<213>  Homosapiens

<400>  527
gtggttgggg aggggggggt ggggggactc tagacagctg aggcgcgaaa gcgatgagtc     60

ctcggctctt cctcctcctt ctccgggacc cgctctctgc ctccctctcc aacgcccgga    120

tgatctgagc cgcgagggcg ccgacagccg ggggcccgga cgcagcccgg ctcctcccct    180

cctccgcccc ttccccagcc tgacctggcc cgccgctgca gcggtgaccc ctcccccggc    240

tgccgccgtc gccgccgcgg tgaccccctc cccggctgcc gccgccgccg cctcggccga    300

ccagggacct gcccgcctgc ggctgctccg gattttaaat aaacttggag ccttttcttg    360

aaagacagct ggctgtggag agccttctac caactgcagt tttagatacg ttttgaaaat    420

ttcatcacct gagacctaga ggatcaagac ataatgggag catttttaga caagccaaag    480

atggaaaagc ataatgccca ggggcagggt aatgggttgc gatatgggct aagcagcatg    540

caaggctggc gtgttgaaat ggaggatgca catacggctg tgatcggttt gccaagtgga    600

cttgaatcgt ggtcattctt tgctgtgtat gatgggcatg ctggttctca ggttgccaaa    660

tactgctgtg agcatttgtt agatcacatc accaataacc aggattttaa agggtctgca    720

ggagcacctt ctgtggaaaa tgtaaagaat ggaatcagaa caggttttct ggagattgat    780

gaacacatga gagttatgtc agagaagaaa catggtgcag atagaagtgg gtcaacagct    840

gtaggtgtct taatttctcc ccaacatact tatttcatta actgtggaga ctcaagaggt    900

ttactttgta ggaacaggaa agttcatttc ttcacacaag atcacaaacc aagtaatccg    960

ctggagaaag aacgaattca gaatgcaggt ggctctgtaa tgattcagcg tgtgaatggc   1020

tctctggctg tatcgagggc ccttggggat tttgattaca aatgtgtcca tggaaaaggt   1080

cctactgagc agcttgtctc accagagcct gaagtccatg atattgaaag atctgaagaa   1140

gatgatcagt tcattatcct tgcatgtgat ggtatctggg atgttatggg aaatgaagag   1200

ctctgtgatt ttgtaagatc cagacttgaa gtcactgatg accttgagaa agtttgcaat   1260

gaagtagtcg acacctgttt gtataaggga agtcgagaca acatgagtgt gattttgatc   1320

tgttttccaa atgcacccaa agtatcgcca gaagcagtga agaaggaggc agagttggac   1380

aagtacctgg aatgcagagt agaaggtgga tcatttaaca aaaaataagt agctttatta   1440

aagaaaaatc ttcaacacaa tcaaacttta acattttagc ttttagattt ttatgtgtct   1500

ttgacagcta gtgtctagtg tatgaaagtg gaaaaggaca tttctgtagt agctgttaag   1560

atgtatgcag ttgtcctatc acagttatat tagaaataac aactagtgtg gaaagtaacc   1620

cacattctgt tcaggatact tttgttttaa aaggctaaaa tgtttgtgtg ctttaaaatt   1680

cttaatgaat tcactggcat gagtaatttt atgccgggaa aatctgattt gtggtctatt   1740

taattacaaa gagattgtga tggtgataat ttgaatacca tctttctatg aaaagctgtg   1800

tatattaatt ttaatctcta gggccttttt tcaataactt gaaaatcaca gcctcatcat   1860

tagcaacttt atatacacag ctttaaaaaa tttgctttaa actgtttcag agcttcttcc   1920

ctaagccata aactgtctca cctaaacaag atagacctca ataaaagaca taatatttct   1980

ccacctggca gaaaagtaac tgccaagtaa gattaagaaa taagttgagc atttctggag   2040

tatatttctc ataattctgc agagacttcc agtttattgc atatatgcag taaagtgtat   2100

atattatgca gtttctctaa gtggaaaaac ttgacatgac tttaatagtg ttaaaacatg   2160

aaaatgctgg tgagctgagg tagaaaaaaa acaagaaaaa aattttaaaa atagcgttaa   2220

aatgcatttt aggctcctaa tgtcgttaat ttgcacgtta aagacctcta atcgcatgca   2280

agcattgacc taccacacct acatcccact gtgcctgcat tattgaaatt actactcact   2340

ttaatttttt ttcccctttt tactgtttga tac                                2373


<210>  528
<211>  324
<212>  PRT
<213>  Homosapiens

<400>  528

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
1               5                   10                  15      


Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
            20                  25                  30          


Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
        35                  40                  45              


Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
    50                  55                  60                  


Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
65                  70                  75                  80  


Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                85                  90                  95      


Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
            100                 105                 110         


Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
        115                 120                 125             


Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
    130                 135                 140                 


Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
145                 150                 155                 160 


Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                165                 170                 175     


Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
            180                 185                 190         


Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
        195                 200                 205             


Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
    210                 215                 220                 


Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
225                 230                 235                 240 


Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                245                 250                 255     


Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
            260                 265                 270         


Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
        275                 280                 285             


Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
    290                 295                 300                 


Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Gly Gly Ser 
305                 310                 315                 320 


Phe Asn Lys Lys 
                


<210>  529
<211>  2373
<212>  DNA
<213>  Homosapiens

<400>  529
aatgtattat gatgtagggg agggaggaag gagggccagg gtagggggca caccctctcc     60

ctgaatgaaa ttcatttagg ggcactgtct gctcgcatgt tctgttctgg gagaaaatgg    120

gtagcagaag ctacaatttg tactaagcta atgaaaagag agaaaagaag aatggggaag    180

agaagggcaa agaaggcaaa aagagaagag aagaaaaagg gaggagagag aaggagaaat    240

gagaaaagag gaaaccaaat gaagaggatg tgtgagagaa aaaaatatga aacagaccta    300

gaggatcaag acataatggg agcattttta gacaagccaa agatggaaaa gcataatgcc    360

caggggcagg gtaatgggtt gcgatatggg ctaagcagca tgcaaggctg gcgtgttgaa    420

atggaggatg cacatacggc tgtgatcggt ttgccaagtg gacttgaatc gtggtcattc    480

tttgctgtgt atgatgggca tgctggttct caggttgcca aatactgctg tgagcatttg    540

ttagatcaca tcaccaataa ccaggatttt aaagggtctg caggagcacc ttctgtggaa    600

aatgtaaaga atggaatcag aacaggtttt ctggagattg atgaacacat gagagttatg    660

tcagagaaga aacatggtgc agatagaagt gggtcaacag ctgtaggtgt cttaatttct    720

ccccaacata cttatttcat taactgtgga gactcaagag gtttactttg taggaacagg    780

aaagttcatt tcttcacaca agatcacaaa ccaagtaatc cgctggagaa agaacgaatt    840

cagaatgcag gtggctctgt aatgattcag cgtgtgaatg gctctctggc tgtatcgagg    900

gcccttgggg attttgatta caaatgtgtc catggaaaag gtcctactga gcagcttgtc    960

tcaccagagc ctgaagtcca tgatattgaa agatctgaag aagatgatca gttcattatc   1020

cttgcatgtg atggtatctg ggatgttatg ggaaatgaag agctctgtga ttttgtaaga   1080

tccagacttg aagtcactga tgaccttgag aaagtttgca atgaagtagt cgacacctgt   1140

ttgtataagg gaagtcgaga caacatgagt gtgattttga tctgttttcc aaatgcaccc   1200

aaagtatcgc cagaagcagt gaagaaggag gcagagttgg acaagtacct ggaatgcaga   1260

gtagaagaaa tcataaagaa gcagggggaa ggcgtccccg acttagtcca tgtgatgcgc   1320

acattagcga gtgagaacat ccccagcctc ccaccagggg gtgaattggc aagcaagagg   1380

aatgttattg aagccgttta caatagactg aatccttaca aaaatgacga cactgactct   1440

acatcaacag atgatatgtg gtaaaactgc tcatctagcc atggagttta ccttcacctc   1500

caaaggagag tacagctcaa ctttgttgaa acttttaaca tccatcctca actttaagga   1560

aggggatatg acatgggtga gaatgattac atcagagaac ttcagcagta caacagctag   1620

cccagaactg attttttttt ttttttttgt aaatttgaga cttatgtaag cgtgatttca   1680

aaccataatt cgtgttgtaa atcagactcc agcaattttt gttgtatgat tttgtttttt   1740

tgtaaagtgt aattgtcctt gtacaaaatg ctcatattta attatgaact gctttaaatc   1800

actatcaaag ttacaagaaa tgtttggctt attgtgtgat gcaacagata tatagccctt   1860

tcaagtcatg ttgtgtttgg acttggggtt ggaacaggga gagcagcagc catgtcagct   1920

acacgctcaa atgtgcagat gattatggaa aataacctca aaatcttaca aagctgaaca   1980

tccaaggagt tattgaaaac tatcttaaat gttcttggta ggggagttgg cattgttgat   2040

aaagccagtc ccttcattta actgtctttc aggatgttcc ttcgttgttt ccatgagtat   2100

tgcaggtaat aatacagtgt attcataaga atctcaatct tggggctaaa tgccttgttt   2160

ctttgcacct cttttcaagt ccttacattt aattactaat tgataagcag cagcttccta   2220

catatagtag gaaactgcca catttttgct atcatgattg gctgggcctg ctgctgttcc   2280

tagtaagata ttctgaattc cattttatca ataaagcttg atttaacaaa caagaaaaaa   2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                2373


<210>  530
<211>  382
<212>  PRT
<213>  Homosapiens

<400>  530

Met Gly Ala Phe Leu Asp Lys Pro Lys Met Glu Lys His Asn Ala Gln 
1               5                   10                  15      


Gly Gln Gly Asn Gly Leu Arg Tyr Gly Leu Ser Ser Met Gln Gly Trp 
            20                  25                  30          


Arg Val Glu Met Glu Asp Ala His Thr Ala Val Ile Gly Leu Pro Ser 
        35                  40                  45              


Gly Leu Glu Ser Trp Ser Phe Phe Ala Val Tyr Asp Gly His Ala Gly 
    50                  55                  60                  


Ser Gln Val Ala Lys Tyr Cys Cys Glu His Leu Leu Asp His Ile Thr 
65                  70                  75                  80  


Asn Asn Gln Asp Phe Lys Gly Ser Ala Gly Ala Pro Ser Val Glu Asn 
                85                  90                  95      


Val Lys Asn Gly Ile Arg Thr Gly Phe Leu Glu Ile Asp Glu His Met 
            100                 105                 110         


Arg Val Met Ser Glu Lys Lys His Gly Ala Asp Arg Ser Gly Ser Thr 
        115                 120                 125             


Ala Val Gly Val Leu Ile Ser Pro Gln His Thr Tyr Phe Ile Asn Cys 
    130                 135                 140                 


Gly Asp Ser Arg Gly Leu Leu Cys Arg Asn Arg Lys Val His Phe Phe 
145                 150                 155                 160 


Thr Gln Asp His Lys Pro Ser Asn Pro Leu Glu Lys Glu Arg Ile Gln 
                165                 170                 175     


Asn Ala Gly Gly Ser Val Met Ile Gln Arg Val Asn Gly Ser Leu Ala 
            180                 185                 190         


Val Ser Arg Ala Leu Gly Asp Phe Asp Tyr Lys Cys Val His Gly Lys 
        195                 200                 205             


Gly Pro Thr Glu Gln Leu Val Ser Pro Glu Pro Glu Val His Asp Ile 
    210                 215                 220                 


Glu Arg Ser Glu Glu Asp Asp Gln Phe Ile Ile Leu Ala Cys Asp Gly 
225                 230                 235                 240 


Ile Trp Asp Val Met Gly Asn Glu Glu Leu Cys Asp Phe Val Arg Ser 
                245                 250                 255     


Arg Leu Glu Val Thr Asp Asp Leu Glu Lys Val Cys Asn Glu Val Val 
            260                 265                 270         


Asp Thr Cys Leu Tyr Lys Gly Ser Arg Asp Asn Met Ser Val Ile Leu 
        275                 280                 285             


Ile Cys Phe Pro Asn Ala Pro Lys Val Ser Pro Glu Ala Val Lys Lys 
    290                 295                 300                 


Glu Ala Glu Leu Asp Lys Tyr Leu Glu Cys Arg Val Glu Glu Ile Ile 
305                 310                 315                 320 


Lys Lys Gln Gly Glu Gly Val Pro Asp Leu Val His Val Met Arg Thr 
                325                 330                 335     


Leu Ala Ser Glu Asn Ile Pro Ser Leu Pro Pro Gly Gly Glu Leu Ala 
            340                 345                 350         


Ser Lys Arg Asn Val Ile Glu Ala Val Tyr Asn Arg Leu Asn Pro Tyr 
        355                 360                 365             


Lys Asn Asp Asp Thr Asp Ser Thr Ser Thr Asp Asp Met Trp 
    370                 375                 380         


<210>  531
<211>  2746
<212>  DNA
<213>  Homosapiens

<400>  531
agttaggatc cgctgtggcg tcctgagtgg agtttgggac cccagggagg gagggtgtgg     60

gcgttcgggt ccagaggagc tgtttagtat ccaagatgaa tgacagcctg tttgtcagtt    120

tggacagact tttgctagaa tttgtcttcc agtatgagca agacataagt actaaagaag    180

agatgattca aagaattaat aaatgctgtg aagatattaa ggaaaacaaa gtaactattt    240

gtaggataca cgaaactata aatgcaacag atgaggaaat tgatcattac tgtaaacata    300

gtgaggagat taaagacaac tgtagaaact ggaagccaac atgtgatgtt tttcgtaaac    360

atgaagatta tatgcaggac caatttactg tttatcaagg aactgttgaa aaagacaaag    420

aaatgtatca tgattatata tgtcagtata aagaagtttt gaagcagtac caactaaaat    480

actcagaaac acccttttca cgtgaatatt atgagaagaa aagagaacat gaagaaattc    540

aaagcagagt gttggcatgt actgaacaat taaaaatgaa tgaaacaatt tttatgaaat    600

ttcgagtgcc tgctcccttt ccatcactta ctaaatggac tttaaacatt gttaatttga    660

gatgtgaaac acaagatatt cttaaacatg ccagcaatct taccaaaagt tcatccgaat    720

tgaagaaaga agtagatgaa atggaaatag aaattaatta tttaaaccag cagatatcta    780

ggcataatga aactaaggct ctttcagaaa ctctggaaga aaagaacaaa aatacagaaa    840

acagaaaaga actgaaagaa agaatttttg gaaaagatga gcatgtactt acattgaata    900

aaactcaaag cagtcaatta tttcttcctt atgaatctca gaaattagta agaccaataa    960

agatgcattc ttcagaacca agagttgcag atataaaaga agaaagttct gtgaagcagt   1020

caaagcttgc caatattgac tttagacaaa aagaaaatga tacacagata tttaatgact   1080

ctgctgtgga taaccattca aaatgttcac atattacgac tatcacaagt tcacaaaagt   1140

ttatgcaagt cagattgtta accccacaga aacaatcaaa ttccaatcag tggtcggaaa   1200

aaggggataa agatgctgag tatggagata aagggacagt aagacaagta agagaatcaa   1260

aatgtacttc acaagctata tatactgaac attttgggaa gtcaatagaa aatgatagtg   1320

atgaagtaga agagagagct gagaattttc cacgaacgtc tgaaattcct atatttttag   1380

gaactcccaa agctgtgaaa gcacctgagt cattggagaa aataaaattc cctaaaaccc   1440

ccccgttcga aattaacaga aatagaaatg cagtacctga agttcaaaca gaaaaggaat   1500

cccctggact ttcttttctt atgagttata cttctagatc acctggattg aatttatttg   1560

attcttctgt atttgataca gaaatctcat cagatcagtt taatgaacat tattctgcaa   1620

gaaatctaaa tcctctgtca tcagagcaag agattggaaa cttatttgag aagccagaag   1680

gagaagatgg ctttacattt tcttttccat cagacacttc aactcataca tttggagctg   1740

gaaaagatga ttttagtttt ccattttcat ttggacaggg tcaaaattca ataccttctt   1800

cttctttaaa aggtttttca tcttcctcac aaaatacaac acagtttact tttttttgag   1860

ctagtcatta attccttaaa ttattttact gttctgtgtt catgagggca taaatttaca   1920

ttattgctta aaacatgaag actgctttct tttattgata aagcagtaat gtttacatta   1980

tttgattata tttattgaaa tattgaaata ctgaatattt tgggttttgt gtgtgctatt   2040

aactaatcat tatttatttt ggttttgatt ttgcgagccg tggtcaggta gaacttttat   2100

taatcttaat agaatttgat gcttttttca ttactcttta tttaaatatt aagcctgctt   2160

ctccttggaa cctaaggttt ttttctggaa gtattgttgg tactttgata agaacaagaa   2220

ctgcagtagt aactccagag ttagtgctga agcgtacttt agctactaaa aatttctatt   2280

aaaattattg ggtttcactt ctgcttcact atgtagtata cagagtggta ctgtaataat   2340

aatttcaaat aatttatgtt aataacaaaa tctgtgttat tttcttctaa tataacacat   2400

ggtacaattc taattttatg agttatgcta atgctttcaa tggctaaaaa ttaaatgtaa   2460

agggcaagag taatttctga aaattggatt gttgtatcag tggtgatcct gttaatattc   2520

ttttttgctt aaatattttt tgaagaacat ttacaatttt gtctccttca ataacaaaaa   2580

tttcttcttt atgttttgtg ttcagtattt gtcaattaat tatatagctt aagtgaagat   2640

atttaagatt tgatgaactt ctgtaaacat tttgctcaat atcattgtat tttgtgcttt   2700

gtaaattagc tgtactgagt taccaagtaa taaagggttt gactcc                  2746


<210>  532
<211>  587
<212>  PRT
<213>  Homosapiens

<400>  532

Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe 
1               5                   10                  15      


Val Phe Gln Tyr Glu Gln Asp Ile Ser Thr Lys Glu Glu Met Ile Gln 
            20                  25                  30          


Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys Val Thr Ile 
        35                  40                  45              


Cys Arg Ile His Glu Thr Ile Asn Ala Thr Asp Glu Glu Ile Asp His 
    50                  55                  60                  


Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg Asn Trp Lys 
65                  70                  75                  80  


Pro Thr Cys Asp Val Phe Arg Lys His Glu Asp Tyr Met Gln Asp Gln 
                85                  90                  95      


Phe Thr Val Tyr Gln Gly Thr Val Glu Lys Asp Lys Glu Met Tyr His 
            100                 105                 110         


Asp Tyr Ile Cys Gln Tyr Lys Glu Val Leu Lys Gln Tyr Gln Leu Lys 
        115                 120                 125             


Tyr Ser Glu Thr Pro Phe Ser Arg Glu Tyr Tyr Glu Lys Lys Arg Glu 
    130                 135                 140                 


His Glu Glu Ile Gln Ser Arg Val Leu Ala Cys Thr Glu Gln Leu Lys 
145                 150                 155                 160 


Met Asn Glu Thr Ile Phe Met Lys Phe Arg Val Pro Ala Pro Phe Pro 
                165                 170                 175     


Ser Leu Thr Lys Trp Thr Leu Asn Ile Val Asn Leu Arg Cys Glu Thr 
            180                 185                 190         


Gln Asp Ile Leu Lys His Ala Ser Asn Leu Thr Lys Ser Ser Ser Glu 
        195                 200                 205             


Leu Lys Lys Glu Val Asp Glu Met Glu Ile Glu Ile Asn Tyr Leu Asn 
    210                 215                 220                 


Gln Gln Ile Ser Arg His Asn Glu Thr Lys Ala Leu Ser Glu Thr Leu 
225                 230                 235                 240 


Glu Glu Lys Asn Lys Asn Thr Glu Asn Arg Lys Glu Leu Lys Glu Arg 
                245                 250                 255     


Ile Phe Gly Lys Asp Glu His Val Leu Thr Leu Asn Lys Thr Gln Ser 
            260                 265                 270         


Ser Gln Leu Phe Leu Pro Tyr Glu Ser Gln Lys Leu Val Arg Pro Ile 
        275                 280                 285             


Lys Met His Ser Ser Glu Pro Arg Val Ala Asp Ile Lys Glu Glu Ser 
    290                 295                 300                 


Ser Val Lys Gln Ser Lys Leu Ala Asn Ile Asp Phe Arg Gln Lys Glu 
305                 310                 315                 320 


Asn Asp Thr Gln Ile Phe Asn Asp Ser Ala Val Asp Asn His Ser Lys 
                325                 330                 335     


Cys Ser His Ile Thr Thr Ile Thr Ser Ser Gln Lys Phe Met Gln Val 
            340                 345                 350         


Arg Leu Leu Thr Pro Gln Lys Gln Ser Asn Ser Asn Gln Trp Ser Glu 
        355                 360                 365             


Lys Gly Asp Lys Asp Ala Glu Tyr Gly Asp Lys Gly Thr Val Arg Gln 
    370                 375                 380                 


Val Arg Glu Ser Lys Cys Thr Ser Gln Ala Ile Tyr Thr Glu His Phe 
385                 390                 395                 400 


Gly Lys Ser Ile Glu Asn Asp Ser Asp Glu Val Glu Glu Arg Ala Glu 
                405                 410                 415     


Asn Phe Pro Arg Thr Ser Glu Ile Pro Ile Phe Leu Gly Thr Pro Lys 
            420                 425                 430         


Ala Val Lys Ala Pro Glu Ser Leu Glu Lys Ile Lys Phe Pro Lys Thr 
        435                 440                 445             


Pro Pro Phe Glu Ile Asn Arg Asn Arg Asn Ala Val Pro Glu Val Gln 
    450                 455                 460                 


Thr Glu Lys Glu Ser Pro Gly Leu Ser Phe Leu Met Ser Tyr Thr Ser 
465                 470                 475                 480 


Arg Ser Pro Gly Leu Asn Leu Phe Asp Ser Ser Val Phe Asp Thr Glu 
                485                 490                 495     


Ile Ser Ser Asp Gln Phe Asn Glu His Tyr Ser Ala Arg Asn Leu Asn 
            500                 505                 510         


Pro Leu Ser Ser Glu Gln Glu Ile Gly Asn Leu Phe Glu Lys Pro Glu 
        515                 520                 525             


Gly Glu Asp Gly Phe Thr Phe Ser Phe Pro Ser Asp Thr Ser Thr His 
    530                 535                 540                 


Thr Phe Gly Ala Gly Lys Asp Asp Phe Ser Phe Pro Phe Ser Phe Gly 
545                 550                 555                 560 


Gln Gly Gln Asn Ser Ile Pro Ser Ser Ser Leu Lys Gly Phe Ser Ser 
                565                 570                 575     


Ser Ser Gln Asn Thr Thr Gln Phe Thr Phe Phe 
            580                 585         


<210>  533
<211>  1391
<212>  DNA
<213>  Homosapiens

<400>  533
tcaacaagcg cctggcacac tcagccaggc ccgcgggcat ctgctgcgtg tcccgctccg     60

ggctcagtgc cctcgccgcc gccggcactg cctcgatgtt ccagctgccc atcttgaatt    120

tcagccccca gcaagtggcc ggggtatgtg agaccctgga agagagcggc gatgtggagc    180

gcctgggtcg cttcctctgg tcgctgcccg tggcccctgc ggcctgcgag gccctcaaca    240

agaatgagtc ggtgctacgc gcacgagcca tcgtggcctt tcacggtggc aactaccgcg    300

agctctatca tatcctggaa aaccacaagt tcaccaagga gtcgcacgcc aagctgcagg    360

cgctgtggct tgaagcccac taccaggagg ctgagaagct gcgtggaaga cccctgggac    420

ctgtggacaa gtaccgagta aggaagaagt tcccgctgcc gcgcaccatt tgggacggcg    480

aacagaagac acactgcttc aaggagcgca cgcggaacct gctacgcgag tggtacctgc    540

aggatccata ccctaacccc agcaaaaaac gtgagctcgc ccaggcaacc ggactgaccc    600

ctacgcaggt gggcaactgg ttcaaaaacc gccgacaaag ggaccgagcg gctgcagcca    660

agaacagact ccagcagcag gtcctgtcac agggttccgg gcgggcacta cgggcggagg    720

gcgacggcac gccagaggtg ctgggcgtcg ccaccagccc ggccgccagt ctatccagca    780

aggcggccac ttcagccatc tccatcacgt ccagcgacag cgagtgcgac atctgagttg    840

cccatccagg atgctcagaa gcagattcca gtgtaaaaac gagaaaaaca aaatgaaaga    900

ggggaagaag atgagagacc tgcaaatcca gcgccagaga agccaggtga ccagggaccc    960

gcgggctcgg gttgccgttt cccgccccac cccgcggccg gcctggcttc actggcgccc   1020

tttggccgcg accacgggaa ccagcggtga ggcctgaccc agcaccacgt tcttcttgct   1080

ttgctttttc ctaaggattt tgctgcaaag tctccttcgg aacccgaact gcaagctgag   1140

cgcctgccca gattctccca tgggtatttc acgtcgaaag gacgctgtta catatgtata   1200

actttcgctt taaagttttt ttttaacaaa acatatatat gctgtttatt tacttattta   1260

agagaccgcc atggtaggtt tctctgtagc ttggggaact tgctgtttct aaacatgcag   1320

gctggtggtg atgggttctg tgtggagaag ccaaacaata aaacaaccta gtgggcaacc   1380

ttcttaatta a                                                        1391


<210>  534
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  534

Met Phe Gln Leu Pro Ile Leu Asn Phe Ser Pro Gln Gln Val Ala Gly 
1               5                   10                  15      


Val Cys Glu Thr Leu Glu Glu Ser Gly Asp Val Glu Arg Leu Gly Arg 
            20                  25                  30          


Phe Leu Trp Ser Leu Pro Val Ala Pro Ala Ala Cys Glu Ala Leu Asn 
        35                  40                  45              


Lys Asn Glu Ser Val Leu Arg Ala Arg Ala Ile Val Ala Phe His Gly 
    50                  55                  60                  


Gly Asn Tyr Arg Glu Leu Tyr His Ile Leu Glu Asn His Lys Phe Thr 
65                  70                  75                  80  


Lys Glu Ser His Ala Lys Leu Gln Ala Leu Trp Leu Glu Ala His Tyr 
                85                  90                  95      


Gln Glu Ala Glu Lys Leu Arg Gly Arg Pro Leu Gly Pro Val Asp Lys 
            100                 105                 110         


Tyr Arg Val Arg Lys Lys Phe Pro Leu Pro Arg Thr Ile Trp Asp Gly 
        115                 120                 125             


Glu Gln Lys Thr His Cys Phe Lys Glu Arg Thr Arg Asn Leu Leu Arg 
    130                 135                 140                 


Glu Trp Tyr Leu Gln Asp Pro Tyr Pro Asn Pro Ser Lys Lys Arg Glu 
145                 150                 155                 160 


Leu Ala Gln Ala Thr Gly Leu Thr Pro Thr Gln Val Gly Asn Trp Phe 
                165                 170                 175     


Lys Asn Arg Arg Gln Arg Asp Arg Ala Ala Ala Ala Lys Asn Arg Leu 
            180                 185                 190         


Gln Gln Gln Val Leu Ser Gln Gly Ser Gly Arg Ala Leu Arg Ala Glu 
        195                 200                 205             


Gly Asp Gly Thr Pro Glu Val Leu Gly Val Ala Thr Ser Pro Ala Ala 
    210                 215                 220                 


Ser Leu Ser Ser Lys Ala Ala Thr Ser Ala Ile Ser Ile Thr Ser Ser 
225                 230                 235                 240 


Asp Ser Glu Cys Asp Ile 
                245     


<210>  535
<211>  1444
<212>  DNA
<213>  Homosapiens

<400>  535
atggcttgtc cacttgacac tcgtttacat gaagtgtcaa cagctttcag gagcaattta     60

ggaagccaaa ctatgggact caataaaaga tgttctttgg atcagaagcc tgctaacttc    120

tttaggcaga agtgccaaag tgcaaaccaa acaaaaataa gtgaagtcat ggaagacaaa    180

aagcagccaa acggcaagat agacaatgga agcccaggac agagaaaaaa atattgtatc    240

caaagagaat gtgaatgggg cgggaggaga ggagaagcag cttttcgctc tattcaacgg    300

ggacgcgaga gcgcggacga tttccgctcc ttttgtgagg cggagcccgg gggcggccgt    360

gaatgggggg tctgtggagc ggccggcggg gctgtcaggc ggctctgcgt aatcagggct    420

aatgacggcg gccgggcgct cggcgggaca atgcgcgggg ccgcggggtt ttgtcggcct    480

gaatggctaa taggtttgcc tgtgagctgc gagggggcgg tgtcggggag gaggcggcgg    540

cgaggggaga aggggtcatt gtccgcgcgc tggcccgggc gccgaggcgt gtccctgcct    600

gcgccgcgcg gctacccccg tgcccggcgc cgccgacggg aaggcagcgg cggggaggcc    660

ccctggaggc ctgctgggaa atggcggctg gagcggcggg cgcgtgggtc ccctcgggga    720

ggcgccccaa gccacggtcc gctcccaaag agaagcccag actgggccca cagtacccgg    780

gaagggcagg aaccagacag aaatggatgg ccgcttgttg gtgaaggact cacagtgagg    840

caaggaagat ctcttcttca tcatgttccc cgtcactgac ttcatcatgt tcaccgtcac    900

tgatttccct taactctatg cctgatcaga acccacaaac caaggagaca cacctggtcc    960

tgttggtcca tttgctattt cgtagttgaa tttcacctca gcattctata tagaagattt   1020

gtattttttt caatcacatg ccctaatgta aatttcatgc attcaagaca gttgattggt   1080

ttccaaaaaa ttaaatacag aattgccaaa tacataatat aacaattcca cttaaagaag   1140

agaatttaac agatctttga acactaatgt tcacagcaac attcatggca gctaaaaggt   1200

agaaacaacc caagtatcat caatagatga atagacaaat aaaacatggt gtagaggata   1260

tggagaaaag ggaacccctg tacactgttg gggggaatgt aaattagtac aaccactatg   1320

aaaaacagtt tggaggttcc tcaaaaaact aaaaatacag ctatcatatg gtccagcaat   1380

cccactgctg ggtatatacc caaaagaaag gaaatcagta tatcaaagag atatctgcac   1440

tccc                                                                1444


<210>  536
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  536

Met Ala Cys Pro Leu Asp Thr Arg Leu His Glu Val Ser Thr Ala Phe 
1               5                   10                  15      


Arg Ser Asn Leu Gly Ser Gln Thr Met Gly Leu Asn Lys Arg Cys Ser 
            20                  25                  30          


Leu Asp Gln Lys Pro Ala Asn Phe Phe Arg Gln Lys Cys Gln Ser Ala 
        35                  40                  45              


Asn Gln Thr Lys Ile Ser Glu Val Met Glu Asp Lys Lys Gln Pro Asn 
    50                  55                  60                  


Gly Lys Ile Asp Asn Gly Ser Pro Gly Gln Arg Lys Lys Tyr Cys Ile 
65                  70                  75                  80  


Gln Arg Glu Cys Glu Trp Gly Gly Arg Arg Gly Glu Ala Ala Phe Arg 
                85                  90                  95      


Ser Ile Gln Arg Gly Arg Glu Ser Ala Asp Asp Phe Arg Ser Phe Cys 
            100                 105                 110         


Glu Ala Glu Pro Gly Gly Gly Arg Glu Trp Gly Val Cys Gly Ala Ala 
        115                 120                 125             


Gly Gly Ala Val Arg Arg Leu Cys Val Ile Arg Ala Asn Asp Gly Gly 
    130                 135                 140                 


Arg Ala Leu Gly Gly Thr Met Arg Gly Ala Ala Gly Phe Cys Arg Pro 
145                 150                 155                 160 


Glu Trp Leu Ile Gly Leu Pro Val Ser Cys Glu Gly Ala Val Ser Gly 
                165                 170                 175     


Arg Arg Arg Arg Arg Gly Glu Lys Gly Ser Leu Ser Ala Arg Trp Pro 
            180                 185                 190         


Gly Arg Arg Gly Val Ser Leu Pro Ala Pro Arg Gly Tyr Pro Arg Ala 
        195                 200                 205             


Arg Arg Arg Arg Arg Glu Gly Ser Gly Gly Glu Ala Pro Trp Arg Pro 
    210                 215                 220                 


Ala Gly Lys Trp Arg Leu Glu Arg Arg Ala Arg Gly Ser Pro Arg Gly 
225                 230                 235                 240 


Gly Ala Pro Ser His Gly Pro Leu Pro Lys Arg Ser Pro Asp Trp Ala 
                245                 250                 255     


His Ser Thr Arg Glu Gly Gln Glu Pro Asp Arg Asn Gly Trp Pro Leu 
            260                 265                 270         


Val Gly Glu Gly Leu Thr Val Arg Gln Gly Arg Ser Leu Leu His His 
        275                 280                 285             


Val Pro Arg His 
    290         


<210>  537
<211>  1378
<212>  DNA
<213>  Homosapiens

<400>  537
ggtagcagca tccaccgggc gggaggtcgg aggcagcaag gccttaaagg ctactgagtg     60

cgccggccgt tccgtgtcca gaacctcccc tactcctccg ccttctcttc cttggccgcc    120

caccgccaag ttccgactcc ggttttcgcc tttgcaaagc ctaaggagga ggttaggaac    180

agccgcgccc ccctccctgc ggccgccgcc ccctgcctct cggctctgct ccctgccgcg    240

tgcgcctggg ccgtgcgccc cggcaggcgc cagccatgtc gatgctgccg tcgtttggct    300

ttacgcagga gcaagtggcg tgcgtgtgcg aggttctgca gcaaggcgga aacctggagc    360

gcctgggcag gttcctgtgg tcactgcccg cctgcgacca cctgcacaag aacgagagcg    420

tactcaaggc caaggcggtg gtcgccttcc accgcggcaa cttccgtgag ctctacaaga    480

tcctggagag ccaccagttc tcgcctcaca accaccccaa actgcagcaa ctgtggctga    540

aggcgcatta cgtggaggcc gagaagctgc gcggccgacc cctgggcgcc gtgggcaaat    600

atcgggtgcg ccgaaaattt ccactgccgc gcaccatctg ggacggcgag gagaccagct    660

actgcttcaa ggagaagtcg aggggtgtcc tgcgggagtg gtacgcgcac aatccctacc    720

catcgccgcg tgagaagcgg gagctggccg aggccaccgg cctcaccacc acccaggtca    780

gcaactggtt taagaaccgg aggcaaagag accgggccgc ggaggccaag gaaagggaga    840

acaccgaaaa caataactcc tcctccaaca agcagaacca actctctcct ctggaagggg    900

gcaagccgct catgtccagc tcagaagagg aattctcacc tccccaaagt ccagaccaga    960

actcggtcct tctgctgcag ggcaatatgg gccacgccag gagctcaaac tattctctcc   1020

cgggcttaac agcctcgcag cccagtcacg gcctgcagac ccaccagcat cagctccaag   1080

actctctgct cggccccctc acctccagtc tggtggactt ggggtcctaa gtggggaggg   1140

actggggcct cgaagggatt cctggagcag caaccactgc agcgactagg gacacttgta   1200

aatagaaatc aggaacattt ttgcagcttg tttctggagt tgtttgcgca taaaggaatg   1260

gtggactttc acaaatatct ttttaaaaat caaaaccaac agcgatctca agcttaatct   1320

cctcttctct ccaactcttt ccacttttgc attttccttc ccaatgcaga gatcaggg     1378


<210>  538
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  538

Met Ser Met Leu Pro Ser Phe Gly Phe Thr Gln Glu Gln Val Ala Cys 
1               5                   10                  15      


Val Cys Glu Val Leu Gln Gln Gly Gly Asn Leu Glu Arg Leu Gly Arg 
            20                  25                  30          


Phe Leu Trp Ser Leu Pro Ala Cys Asp His Leu His Lys Asn Glu Ser 
        35                  40                  45              


Val Leu Lys Ala Lys Ala Val Val Ala Phe His Arg Gly Asn Phe Arg 
    50                  55                  60                  


Glu Leu Tyr Lys Ile Leu Glu Ser His Gln Phe Ser Pro His Asn His 
65                  70                  75                  80  


Pro Lys Leu Gln Gln Leu Trp Leu Lys Ala His Tyr Val Glu Ala Glu 
                85                  90                  95      


Lys Leu Arg Gly Arg Pro Leu Gly Ala Val Gly Lys Tyr Arg Val Arg 
            100                 105                 110         


Arg Lys Phe Pro Leu Pro Arg Thr Ile Trp Asp Gly Glu Glu Thr Ser 
        115                 120                 125             


Tyr Cys Phe Lys Glu Lys Ser Arg Gly Val Leu Arg Glu Trp Tyr Ala 
    130                 135                 140                 


His Asn Pro Tyr Pro Ser Pro Arg Glu Lys Arg Glu Leu Ala Glu Ala 
145                 150                 155                 160 


Thr Gly Leu Thr Thr Thr Gln Val Ser Asn Trp Phe Lys Asn Arg Arg 
                165                 170                 175     


Gln Arg Asp Arg Ala Ala Glu Ala Lys Glu Arg Glu Asn Thr Glu Asn 
            180                 185                 190         


Asn Asn Ser Ser Ser Asn Lys Gln Asn Gln Leu Ser Pro Leu Glu Gly 
        195                 200                 205             


Gly Lys Pro Leu Met Ser Ser Ser Glu Glu Glu Phe Ser Pro Pro Gln 
    210                 215                 220                 


Ser Pro Asp Gln Asn Ser Val Leu Leu Leu Gln Gly Asn Met Gly His 
225                 230                 235                 240 


Ala Arg Ser Ser Asn Tyr Ser Leu Pro Gly Leu Thr Ala Ser Gln Pro 
                245                 250                 255     


Ser His Gly Leu Gln Thr His Gln His Gln Leu Gln Asp Ser Leu Leu 
            260                 265                 270         


Gly Pro Leu Thr Ser Ser Leu Val Asp Leu Gly Ser 
        275                 280                 


<210>  539
<211>  6214
<212>  DNA
<213>  Homosapiens

<400>  539
atgtcctctt cctcccccac cgggcagatc gcaagtgcgg cggacatcaa gcaagagaat     60

gggatggaaa gcgcctcgga agggcaggag gcgcaccgag aagtggcggg gggcgcggcg    120

gtagggctga gccccccggc tccagcccct tttcccctgg agccggggga cgccgcgacc    180

gctgccgcca gggtgagcgg agaggaaggg gcagtggcgg cggcggcggc cggagcggcg    240

gcggatcagg tacaactcca ctcggaactt ctgggcaggc accaccacgc cgccgccgcc    300

gccgcgcaga ccccgctggc cttctcgccc gaccacgtcg cctgcgtgtg cgaggcactg    360

cagcaggggg gcaacctgga ccgcctggcc cggttcctgt ggtccctgcc ccagagcgac    420

ctgctacgtg gcaacgagag cctgctgaag gcgcgggcgc tcgtggcctt ccaccagggc    480

atctaccccg agctctacag catcctcgag agccacagct tcgagtcggc caaccacccg    540

ctgctgcagc agctctggta caaggcgcgc tacaccgagg ccgagcgagc ccgcggccgg    600

ccgctgggag ccgtagacaa gtaccggctg cgcaggaaat tccccctgcc ccgcaccatc    660

tgggacggcg aggagacggt gtattgtttc aaggagaagt cgcgcaacgc gctcaaggag    720

ctctacaagc agaatcgcta cccttcgccc gccgagaagc ggcacctggc caagatcacc    780

ggcctctccc tcacccaggt cagcaactgg ttcaagaacc gccggcagcg cgacaggaac    840

ccctccgaga cccagtccaa aagtgagtca gatggcaacc ccagcactga agatgaatcc    900

agcaagggac atgaggattt atctcctcac ccactctcca gttcatctga tggcatcacc    960

aacctcagcc tttccagtca tatggagcca gtatatatgc aacaaattgg aaatgctaag   1020

atatcattaa gctcttctgg agttctgttg aatggaagct tggtacctgc aagtacttca   1080

cctgtcttcc ttaatggaaa ttcttttatt cagggaccca gtggagttat ccttaatgga   1140

ttaaatgtgg gaaatacaca ggcagtggca ttgaacccac caaaaatgtc atcaaacatt   1200

gtgagcaatg gtatatccat gactgacata ctggggtcta cttcccagga cgtgaaggaa   1260

ttcaaagtcc tccagagttc tgctaactca gcaaccacca cgtcctacag ccccagtgtc   1320

cctgtctcat tcccaggcct gatacccagc actgaggtga aaagagaagg cattcaaaca   1380

gtggcttccc aagatggagg gtctgtagtg acttttacta caccagtgca aattaaccag   1440

tatggcattg tccagatccc caattccgga gcaaacagcc agttccttaa tgggagcatt   1500

ggattctctc cactgcagct gccccctgtg tcagtggcag cttcacaagg taatatctca   1560

gtaagctcaa gcacttcaga tggaagcaca tttacaagtg agtctaccac agtccagcaa   1620

ggaaaggttt tcttgagctc tcttgctccc agtgcagtgg tatacacggt tcctaataca   1680

ggccagacta taggatctgt gaaacaggaa ggcttggaaa ggagcctggt attttctcag   1740

ttgatgcctg tcaatcagaa tgcacaagta aatgcaaacc tgtcttctga aaacatctcg   1800

gggagtggcc tgcctccact ggcctcctca ttagttaatg tatctccaac tcacaatttt   1860

tctctcagtc cctctacact actaaatccc actgagctaa accgcgacat tgccgatagc   1920

caaccaatgt ctgcaccggt ggcaagcaaa tctactgtga catctgtcag caacactaac   1980

tatgcaactc ttcagaactg ctcccttatt actggtcaag acctattgtc agtccctatg   2040

actcaggctg cccttgggga aatagttcct acagctgaag atcaggtagg tcacccctcc   2100

ccagcagtac atcaggattt tgtccaagaa catcgtttgg ttctgcaatc ggtagctaac   2160

atgaaagaga atttcttatc aaattctgag agcaaagcaa caagtagctt aatgatgctg   2220

gactctaaat ccaagtatgt cttagatggc atggttgata ctgtctgtga agacctggaa   2280

acagacaaaa aagagcttgc caagctccag actgtccagc tggatgaaga tatgcaagac   2340

ttatgaactt tatttcctcc tcacctcttt ttggcatcag cggcaaatct tttcatgaag   2400

ccccaaggac acaaaacatt ttcccattta aaggaaaaca ctctagtttt gcaagtatat   2460

gcatacaaga gactttagat tgatctgcat gaagatcaca gttaagtata caggagtaga   2520

actgcattat tgcagccttt ttgttcactt ataaatttct cttttaaata gatggagaca   2580

aaggacaagg tgaaatgtat caagtcaaag tgaatcattt agttgactct ataattctaa   2640

ggtcaaaatg gaacttgata gttttttaaa ttaaaaaatg tatacaccta acatagaaaa   2700

ttaaagatag ctgcagacca ttagaaataa tacaattgtt tttgtttact tttactccat   2760

gggcattgaa aaggttaaga aacataaatg gtacatattt ttaaagttaa gtagcatgca   2820

tatatatatg cacacacacc tctttttcag cattttttga gaaagtcttg ggtctcaaac   2880

acatttgtct caacacattt ccaaatgtga tttctaatag ctcagtgtgg ctgagaaagt   2940

gcggaactcc actaaaaact ctgaaacttc agtataaatg taaatatatc agttctataa   3000

gcaggatttg agtaattaca gtgaatttta tttttaatgt atatgtttct cttcaggcgc   3060

tatgaactga aaaatatgtt ttcttactgt ttaatttatt tttattgttt gaacaggaag   3120

tgaacatagt cgtttccaac aaagttttac tttttgtagg attttaaaaa taatgatttt   3180

taccaggaat ctattaaggt caatattaat aacactgaaa caggaaatct aactcccaat   3240

attggaattt tggtactttt tttcacatcc ttgttcttta tttagcaact ctgattcatt   3300

taaatatgtt ttttatagaa ttctatgtgc ctttttacct cgtggccttt ttattggtag   3360

taaggtacag aagtgtcaac agaagcactg atggttcttt tctactatct aacagggtta   3420

atttcaccac aaaattgctt taaatctgaa gaacttaagt ttcactaaat aatatatatg   3480

acatttatca cacaaatgga taaacaacta attattgttg atacttttca ttacaaggaa   3540

aataagttat aaataccatg tcaaattgat tatacaggct atgaaaacca ttttaaagga   3600

aagaaaatat gtaaattcta ttgagcaaaa ttctgtcctg ttgaaactta gttctaaagg   3660

ttttgaatca gttgttacac tctgacacat gactgttgtt tgcactatat tatcatgtct   3720

tctttaaaag taaatatttt tggtttctgt aagaagcttg tttaataatg ttgtaagccg   3780

tggctatagt tttatcaaga ctctgaacac aagatgtaac aatgcaaata aatttatgta   3840

gtgagtaaag ttgctctcta gtctctgaaa agcaaaaaaa gtgagaaaat aatttcttca   3900

gagataactt caagttgttg aacataaagg tgttagatgt tagcacatct tgcttttttt   3960

ttttttttga gatggagtct cgctctgttg cccaggctgg agtgcagtgg cacgatcttg   4020

gctcactgca agctctgcct cctgggttca cgccattctc ctgcctcagc ctcccgagta   4080

gctgggacta caggcacctg ccaccatgcc cggctaaatt tttgtatttt tagtagagac   4140

ggggtttcac cgtgttagcc aggatggtct tgatctcctg acctcgtgat ctgcccgcct   4200

cggcctccca aagtgctggg attataggca tgagccactg tgcctggcca catcttgctt   4260

ttttttttat gatcagaaca aagggcccac tctagttctc tacatgtcaa tcaatcaagc   4320

atgttgaata agggacatag aggatttaac ttttgttatc ataaatggaa cttgcaggca   4380

tatatcaaga accctatgaa gaattcctct cccatcattt tgataaagaa ctacatcatt   4440

tttgatagaa ttggtgaatg ttcctaaact gctgaagcta catgtttttt gttttgtttt   4500

acaaagtcag gtgtttgaga gttcttttcc actctactac tactcataga gcttgttttt   4560

tctttgggtg tgtgctgatc ctgttactga gattaattac atggctctgc agtgtagttt   4620

acataaaaat gatgttttcc acttgattgc tgcagatatc aagagtttgt tattttcaaa   4680

tacccatcca acaagagaga tggggaggtt tttagttata tatgctatat atatatatat   4740

aactggaaat gttttatatg ttttccgaaa atacaataag cctctctttt attcagtgtt   4800

cttcctcttt tctcccttat gaaaaagaaa agatagcaca aaacttaaga cttacctagg   4860

aaacccattc atattcccac catgatgtaa ttataaccct acaattactt caggtagcta   4920

cacaatatac caggtaagaa tcaatgcaca gtataaagaa cttattgttc ttttctattc   4980

tttcagttga ataagggcca gttggtatgc agcccatgta tatgtgaatg gagtaagata   5040

aaccccatga tctccttgca cagaattgca aatgtctttt gccataccaa gggccagact   5100

cagaaccctt ggagtcatgt ggcagaattt ccctcttaca taaaccaatg cttgaaaatg   5160

ctgcaaatga ccctctaatg atccctgaag atcaaaacag gggtaaatga ctccctgcaa   5220

aacccaaccc atgctgctgg ctgtgggatt tttggtgtaa gcctatctat gcactctatc   5280

agccagaatt tggcatttag ctcttagtta aatctagtaa aggacagtct attgtttaaa   5340

gagaaggtgc atttgttcct caatcaagca agagcacctg tgttgtactg ctttatatct   5400

catgtatatt tatagtaatg aaaagacttt ttaaattgta cacgtttcag tgcctttctt   5460

gtgttatgaa aggcaggtag atattatagc cataggtaaa aatccatagt taaattgcac   5520

actgacctta aatctctctg tgtatgccct tgtatcttgc atgttaaaag ttggattatt   5580

gggcatgtgt ggcagcctgc cctgctacat gctagacaag tgtgctttag tacatagcca   5640

caagttcttc attctttaaa atgttttgac agatcatctc ataataaaaa taattcagga   5700

aaactatggg gaaatagtta catttcacaa aagatatttt aaactctttg taaaacttag   5760

ataatagagc ctagcagtta ctttgtatct aattgataca ttttatgtta atttaccacc   5820

atacatttta ttaatcaaaa ttgtatagca tgtgactctt ttggctttca gagttctcaa   5880

aaatattatt ttgttgcatg tactgtatgt ttagaggcaa ccaattatat actcaatatg   5940

gttttactgt gccttacaca aagagaaact ctatacagaa tgtatatcat ggggtggggt   6000

aacagagtct ttactgcact gttaggtgat ggcacacaga gcatgtccca gaacatttct   6060

gtgcttaatt acccaaccaa agagatctga agtatgtatg tcgtactgta atgggggttt   6120

atgcctggac aattaagtgt tttatttgtt ttctgaaatg atgtgaactt atttttctaa   6180

acactatgct aaataaactt tatatttata cata                               6214


<210>  540
<211>  781
<212>  PRT
<213>  Homosapiens

<400>  540

Met Ser Ser Ser Ser Pro Thr Gly Gln Ile Ala Ser Ala Ala Asp Ile 
1               5                   10                  15      


Lys Gln Glu Asn Gly Met Glu Ser Ala Ser Glu Gly Gln Glu Ala His 
            20                  25                  30          


Arg Glu Val Ala Gly Gly Ala Ala Val Gly Leu Ser Pro Pro Ala Pro 
        35                  40                  45              


Ala Pro Phe Pro Leu Glu Pro Gly Asp Ala Ala Thr Ala Ala Ala Arg 
    50                  55                  60                  


Val Ser Gly Glu Glu Gly Ala Val Ala Ala Ala Ala Ala Gly Ala Ala 
65                  70                  75                  80  


Ala Asp Gln Val Gln Leu His Ser Glu Leu Leu Gly Arg His His His 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Gln Thr Pro Leu Ala Phe Ser Pro Asp His 
            100                 105                 110         


Val Ala Cys Val Cys Glu Ala Leu Gln Gln Gly Gly Asn Leu Asp Arg 
        115                 120                 125             


Leu Ala Arg Phe Leu Trp Ser Leu Pro Gln Ser Asp Leu Leu Arg Gly 
    130                 135                 140                 


Asn Glu Ser Leu Leu Lys Ala Arg Ala Leu Val Ala Phe His Gln Gly 
145                 150                 155                 160 


Ile Tyr Pro Glu Leu Tyr Ser Ile Leu Glu Ser His Ser Phe Glu Ser 
                165                 170                 175     


Ala Asn His Pro Leu Leu Gln Gln Leu Trp Tyr Lys Ala Arg Tyr Thr 
            180                 185                 190         


Glu Ala Glu Arg Ala Arg Gly Arg Pro Leu Gly Ala Val Asp Lys Tyr 
        195                 200                 205             


Arg Leu Arg Arg Lys Phe Pro Leu Pro Arg Thr Ile Trp Asp Gly Glu 
    210                 215                 220                 


Glu Thr Val Tyr Cys Phe Lys Glu Lys Ser Arg Asn Ala Leu Lys Glu 
225                 230                 235                 240 


Leu Tyr Lys Gln Asn Arg Tyr Pro Ser Pro Ala Glu Lys Arg His Leu 
                245                 250                 255     


Ala Lys Ile Thr Gly Leu Ser Leu Thr Gln Val Ser Asn Trp Phe Lys 
            260                 265                 270         


Asn Arg Arg Gln Arg Asp Arg Asn Pro Ser Glu Thr Gln Ser Lys Ser 
        275                 280                 285             


Glu Ser Asp Gly Asn Pro Ser Thr Glu Asp Glu Ser Ser Lys Gly His 
    290                 295                 300                 


Glu Asp Leu Ser Pro His Pro Leu Ser Ser Ser Ser Asp Gly Ile Thr 
305                 310                 315                 320 


Asn Leu Ser Leu Ser Ser His Met Glu Pro Val Tyr Met Gln Gln Ile 
                325                 330                 335     


Gly Asn Ala Lys Ile Ser Leu Ser Ser Ser Gly Val Leu Leu Asn Gly 
            340                 345                 350         


Ser Leu Val Pro Ala Ser Thr Ser Pro Val Phe Leu Asn Gly Asn Ser 
        355                 360                 365             


Phe Ile Gln Gly Pro Ser Gly Val Ile Leu Asn Gly Leu Asn Val Gly 
    370                 375                 380                 


Asn Thr Gln Ala Val Ala Leu Asn Pro Pro Lys Met Ser Ser Asn Ile 
385                 390                 395                 400 


Val Ser Asn Gly Ile Ser Met Thr Asp Ile Leu Gly Ser Thr Ser Gln 
                405                 410                 415     


Asp Val Lys Glu Phe Lys Val Leu Gln Ser Ser Ala Asn Ser Ala Thr 
            420                 425                 430         


Thr Thr Ser Tyr Ser Pro Ser Val Pro Val Ser Phe Pro Gly Leu Ile 
        435                 440                 445             


Pro Ser Thr Glu Val Lys Arg Glu Gly Ile Gln Thr Val Ala Ser Gln 
    450                 455                 460                 


Asp Gly Gly Ser Val Val Thr Phe Thr Thr Pro Val Gln Ile Asn Gln 
465                 470                 475                 480 


Tyr Gly Ile Val Gln Ile Pro Asn Ser Gly Ala Asn Ser Gln Phe Leu 
                485                 490                 495     


Asn Gly Ser Ile Gly Phe Ser Pro Leu Gln Leu Pro Pro Val Ser Val 
            500                 505                 510         


Ala Ala Ser Gln Gly Asn Ile Ser Val Ser Ser Ser Thr Ser Asp Gly 
        515                 520                 525             


Ser Thr Phe Thr Ser Glu Ser Thr Thr Val Gln Gln Gly Lys Val Phe 
    530                 535                 540                 


Leu Ser Ser Leu Ala Pro Ser Ala Val Val Tyr Thr Val Pro Asn Thr 
545                 550                 555                 560 


Gly Gln Thr Ile Gly Ser Val Lys Gln Glu Gly Leu Glu Arg Ser Leu 
                565                 570                 575     


Val Phe Ser Gln Leu Met Pro Val Asn Gln Asn Ala Gln Val Asn Ala 
            580                 585                 590         


Asn Leu Ser Ser Glu Asn Ile Ser Gly Ser Gly Leu Pro Pro Leu Ala 
        595                 600                 605             


Ser Ser Leu Val Asn Val Ser Pro Thr His Asn Phe Ser Leu Ser Pro 
    610                 615                 620                 


Ser Thr Leu Leu Asn Pro Thr Glu Leu Asn Arg Asp Ile Ala Asp Ser 
625                 630                 635                 640 


Gln Pro Met Ser Ala Pro Val Ala Ser Lys Ser Thr Val Thr Ser Val 
                645                 650                 655     


Ser Asn Thr Asn Tyr Ala Thr Leu Gln Asn Cys Ser Leu Ile Thr Gly 
            660                 665                 670         


Gln Asp Leu Leu Ser Val Pro Met Thr Gln Ala Ala Leu Gly Glu Ile 
        675                 680                 685             


Val Pro Thr Ala Glu Asp Gln Val Gly His Pro Ser Pro Ala Val His 
    690                 695                 700                 


Gln Asp Phe Val Gln Glu His Arg Leu Val Leu Gln Ser Val Ala Asn 
705                 710                 715                 720 


Met Lys Glu Asn Phe Leu Ser Asn Ser Glu Ser Lys Ala Thr Ser Ser 
                725                 730                 735     


Leu Met Met Leu Asp Ser Lys Ser Lys Tyr Val Leu Asp Gly Met Val 
            740                 745                 750         


Asp Thr Val Cys Glu Asp Leu Glu Thr Asp Lys Lys Glu Leu Ala Lys 
        755                 760                 765             


Leu Gln Thr Val Gln Leu Asp Glu Asp Met Gln Asp Leu 
    770                 775                 780     


<210>  541
<211>  833
<212>  DNA
<213>  Homosapiens

<400>  541
gttaaacaag tgcttgaagg cagtatgctt ggtaaaagtc atcgccattc tctaatcttg     60

agtacccagg gacacgatac actgcggaag gctgcaggga cctctgccca ggaaagccag    120

gcttgcatga aggaaatgat ttcctatgat tctgcttact gcttaaaaaa attaatcaag    180

ttttctgcct gacaagatcc agtatctgcc ggaggagccc caccttctgc tactattatg    240

ttcttcagat gagtagaaga gagtggggag ggagagagca ggaagaagaa aggaagaata    300

atgtcttgaa attgttttct aaggataatg gtctccagct tcgtcaatgt tcctgcaaag    360

gacatgatgc tgactttgaa gatgcaagct tccacatcta cagcctcaag gaaacaaatt    420

cagccaacca actgagggag ctttccttgt cctgcctcaa gatgagatca cagtctgccc    480

aacaccatga tttaggcctt gtgacacctg gtatggaaga cccagttaag ttctctccaa    540

actcttgacc cacagaacct gtgagaaaat atatggatat tattttaaac tgctaaattt    600

gtagtaattt gttatgcagc aataaaaaaa actaatgcaa ggagatatca attattgtaa    660

aaagcttagc ttttgtttta aaatatagtt caccagtagt aagttactaa taagtaacta    720

aacaaataaa agcaagccat ttacaaatca ataataagag taagtcatga actaaagatt    780

gtaattaatc aatttctgta cgcctgtaat gaaaataaag gaggaaaaga aaa           833


<210>  542
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  542

Met Ser Arg Arg Glu Trp Gly Gly Arg Glu Gln Glu Glu Glu Arg Lys 
1               5                   10                  15      


Asn Asn Val Leu Lys Leu Phe Ser Lys Asp Asn Gly Leu Gln Leu Arg 
            20                  25                  30          


Gln Cys Ser Cys Lys Gly His Asp Ala Asp Phe Glu Asp Ala Ser Phe 
        35                  40                  45              


His Ile Tyr Ser Leu Lys Glu Thr Asn Ser Ala Asn Gln Leu Arg Glu 
    50                  55                  60                  


Leu Ser Leu Ser Cys Leu Lys Met Arg Ser Gln Ser Ala Gln His His 
65                  70                  75                  80  


Asp Leu Gly Leu Val Thr Pro Gly Met Glu Asp Pro Val Lys Phe Ser 
                85                  90                  95      


Pro Asn Ser 
            


<210>  543
<211>  2401
<212>  DNA
<213>  Homosapiens

<400>  543
gcaaggcatg gagcctgcac tttactctga atgttggtgg cgccttcaga gcattgttag     60

caagggtcca tgtgatcaca ctgacacctg agagagtgac acaccatgta catggctggt    120

atatggagga tggatttaag ggggacagga ctgaaggctg tcgcagtgat tcagtggccg    180

ttcccgcagc agcaccggtg tgccagccca agagcgccac taacgggcaa cccccggctc    240

cggctccgac tccaactccg cgcctgtcca tttcctcccg agccacagtg gtagccagga    300

tggaaggcac ctcccaaggg ggcttgcaga ccgtcatgaa gtggaagacg gtggttgcca    360

tctttgtggt tgtggtggtc taccttgtca ctggcggtct tgtcttccgg gcattggagc    420

agccctttga gagcagccag aagaatacca tcgccttgga gaaggcggaa ttcctgcggg    480

atcatgtctg tgtgagcccc caggagctgg agacgttgat ccagcatgct cttgatgctg    540

acaatgcggg agtcagtcca ataggaaact cttccaacaa cagcagccac tgggacctcg    600

gcagtgcctt tttctttgct ggaactgtca ttacgaccat agggtatggg aatattgctc    660

cgagcactga aggaggcaaa atcttttgta ttttatatgc catctttgga attccactct    720

ttggtttctt attggctgga attggagacc aacttggaac catctttggg aaaagcattg    780

caagagtgga gaaggtcttt cgaaaaaagc aagtgagtca gaccaagatc cgggtcatct    840

caaccatcct gttcatcttg gccggctgca ttgtgtttgt gacgatccct gctgtcatct    900

ttaagtacat cgagggctgg acggccttgg agtccattta ctttgtggtg gtcactctga    960

ccacggtggg ctttggtgat tttgtggcag ggggaaacgc tggcatcaat tatcgggagt   1020

ggtataagcc cctagtgtgg ttttggatcc ttgttggcct tgcctacttt gcagctgtcc   1080

tcagtatgat cggagattgg ctacgggttc tgtccaaaaa gacaaaagaa gaggtgggtg   1140

aaatcaaggc ccatgcggca gagtggaagg ccaatgtcac ggctgagttc cgggagacac   1200

ggcgaaggct cagcgtggag atccacgata agctgcagcg ggcggccacc atccgcagca   1260

tggagcgccg gcggctgggc ctggaccagc gggcccactc actggacatg ctgtcccccg   1320

agaagcgctc tgtctttgct gccctggaca ccggccgctt caaggcctca tcccaggaga   1380

gcatcaacaa ccggcccaac aacctgcgcc tgaaggggcc ggagcagctg aacaagcatg   1440

ggcagggtgc gtccgaggac aacatcatca acaagttcgg gtccacctcc agactcacca   1500

agaggaaaaa caaggacctc aaaaagacct tgcccgagga cgttcagaaa atctacaaga   1560

ccttccggaa ttactccctg gacgaggaga agaaagagga ggagacggaa aagatgtgta   1620

actcagacaa ctccagcaca gccatgctga cggactgtat ccagcagcac gctgagttgg   1680

agaacggaat gatacccacg gacaccaaag accgggagcc ggagaacaac tcattacttg   1740

aagacagaaa ctaaatgtga aggacattgg tcttggactg agcgttgtgt gtgtgtgtgt   1800

gtgtgttttt aatattcaca ctgagacatg tgccttaaac agacttttta gtccaaaatt   1860

acatagcatt gaagaatata tttcactgtg ccataaacaa ctgaaagctt gctctgccaa   1920

aaggaatcag agaacaagaa cttcatttca gatagcaaac gcaggacaca ccaagagtgt   1980

ccgtgcacgt agccggttct ggccgtacat gttaagggca tttcagtggc agtgctgtac   2040

ccctgggcag tgctacctgg gcacacacgt agacaagggc agctattcct tagaccagcc   2100

tcctgaaaga aacaggtgtg tctttttagt ggagtcgtag taatatgtgc acacacagaa   2160

ggggacctga ttgggtggga gctggttatg tgtaactagc gttggagttg acattttggc   2220

atgtgctctg agcttgaatt ttgataccaa ccattcagtg catcatacct agtctttcta   2280

tgctccaaat gaatgtctgt ggggacctga gagcacctgg aatttgttgg aagcagatca   2340

gagcacacgt acgaaaaggt gcaattgctt ttctcatgac aaaagaaaaa aaaaaaaaaa   2400

a                                                                   2401


<210>  544
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  544

Met Glu Asp Gly Phe Lys Gly Asp Arg Thr Glu Gly Cys Arg Ser Asp 
1               5                   10                  15      


Ser Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala 
            20                  25                  30          


Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu 
        35                  40                  45              


Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser 
    50                  55                  60                  


Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile 
65                  70                  75                  80  


Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg 
                85                  90                  95      


Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu 
            100                 105                 110         


Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu 
        115                 120                 125             


Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val 
    130                 135                 140                 


Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly 
145                 150                 155                 160 


Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly 
                165                 170                 175     


Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr 
            180                 185                 190         


Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly 
        195                 200                 205             


Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys 
    210                 215                 220                 


Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser 
225                 230                 235                 240 


Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro 
                245                 250                 255     


Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile 
            260                 265                 270         


Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val 
        275                 280                 285             


Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu 
    290                 295                 300                 


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
305                 310                 315                 320 


Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu 
                325                 330                 335     


Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val 
            340                 345                 350         


Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His 
        355                 360                 365             


Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg 
    370                 375                 380                 


Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu 
385                 390                 395                 400 


Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser 
                405                 410                 415     


Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly 
            420                 425                 430         


Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile 
        435                 440                 445             


Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys 
    450                 455                 460                 


Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr 
465                 470                 475                 480 


Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu 
                485                 490                 495     


Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys 
            500                 505                 510         


Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr 
        515                 520                 525             


Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535                 540             


<210>  545
<211>  2710
<212>  DNA
<213>  Homosapiens

<400>  545
gcaggcatcg tctcctccgg tctcacagct accccgggct ggagcgtggg gagggggtaa     60

gggagccagc caactcgggg aaacttcgtt gccagagatg actggggttt tcgggctttc    120

ccagccttcc catgccgggc cacacggcat tcattaaagt ggtggggcaa ctattggtgc    180

gctccagccg ggcaggtttt gagctgcaga gacccgtgcc cggtagcagc gctttgccac    240

cgagtgcacc caggacgcag tggccgccag cccgggtctc ctgctggggg ccggcgagtg    300

cagggagact ttgcgccacg atgttttgtt ttcctgccgc aggaacgcta ggcagtctct    360

ttccaccaga cttaacccgc ctgaagcaat agccatggaa gttgcggcgg cacagaggga    420

gacagaaccg cttggagcgg catctttctt ggatgttttt tctctacaca gacttctttc    480

tttccttggt ggccgttccc gcagcagcac cggtgtgcca gcccaagagc gccactaacg    540

ggcaaccccc ggctccggct ccgactccaa ctccgcgcct gtccatttcc tcccgagcca    600

cagtggtagc caggatggaa ggcacctccc aagggggctt gcagaccgtc atgaagtgga    660

agacggtggt tgccatcttt gtggttgtgg tggtctacct tgtcactggc ggtcttgtct    720

tccgggcatt ggagcagccc tttgagagca gccagaagaa taccatcgcc ttggagaagg    780

cggaattcct gcgggatcat gtctgtgtga gcccccagga gctggagacg ttgatccagc    840

atgctcttga tgctgacaat gcgggagtca gtccaatagg aaactcttcc aacaacagca    900

gccactggga cctcggcagt gcctttttct ttgctggaac tgtcattacg accatagggt    960

atgggaatat tgctccgagc actgaaggag gcaaaatctt ttgtatttta tatgccatct   1020

ttggaattcc actctttggt ttcttattgg ctggaattgg agaccaactt ggaaccatct   1080

ttgggaaaag cattgcaaga gtggagaagg tctttcgaaa aaagcaagtg agtcagacca   1140

agatccgggt catctcaacc atcctgttca tcttggccgg ctgcattgtg tttgtgacga   1200

tccctgctgt catctttaag tacatcgagg gctggacggc cttggagtcc atttactttg   1260

tggtggtcac tctgaccacg gtgggctttg gtgattttgt ggcaggggga aacgctggca   1320

tcaattatcg ggagtggtat aagcccctag tgtggttttg gatccttgtt ggccttgcct   1380

actttgcagc tgtcctcagt atgatcggag attggctacg ggttctgtcc aaaaagacaa   1440

aagaagaggt gggtgaaatc aaggcccatg cggcagagtg gaaggccaat gtcacggctg   1500

agttccggga gacacggcga aggctcagcg tggagatcca cgataagctg cagcgggcgg   1560

ccaccatccg cagcatggag cgccggcggc tgggcctgga ccagcgggcc cactcactgg   1620

acatgctgtc ccccgagaag cgctctgtct ttgctgccct ggacaccggc cgcttcaagg   1680

cctcatccca ggagagcatc aacaaccggc ccaacaacct gcgcctgaag gggccggagc   1740

agctgaacaa gcatgggcag ggtgcgtccg aggacaacat catcaacaag ttcgggtcca   1800

cctccagact caccaagagg aaaaacaagg acctcaaaaa gaccttgccc gaggacgttc   1860

agaaaatcta caagaccttc cggaattact ccctggacga ggagaagaaa gaggaggaga   1920

cggaaaagat gtgtaactca gacaactcca gcacagccat gctgacggac tgtatccagc   1980

agcacgctga gttggagaac ggaatgatac ccacggacac caaagaccgg gagccggaga   2040

acaactcatt acttgaagac agaaactaaa tgtgaaggac attggtcttg gactgagcgt   2100

tgtgtgtgtg tgtgtgtgtg tgtttttaat attcacactg agacatgtgc cttaaacaga   2160

ctttttagtc caaaattaca tagcattgaa gaatatattt cactgtgcca taaacaactg   2220

aaagcttgct ctgccaaaag gaatcagaga acaagaactt catttcagat agcaaacgca   2280

ggacacacca agagtgtccg tgcacgtagc cggttctggc cgtacatgtt aagggcattt   2340

cagtggcagt gctgtacccc tgggcagtgc tacctgggca cacacgtaga caagggcagc   2400

tattccttag accagcctcc tgaaagaaac aggtgtgtct ttttagtgga gtcgtagtaa   2460

tatgtgcaca cacagaaggg gacctgattg ggtgggagct ggttatgtgt aactagcgtt   2520

ggagttgaca ttttggcatg tgctctgagc ttgaattttg ataccaacca ttcagtgcat   2580

catacctagt ctttctatgc tccaaatgaa tgtctgtggg gacctgagag cacctggaat   2640

ttgttggaag cagatcagag cacacgtacg aaaaggtgca attgcttttc tcatgacaaa   2700

agaaaaaaaa                                                          2710


<210>  546
<211>  538
<212>  PRT
<213>  Homosapiens

<400>  546

Met Phe Phe Leu Tyr Thr Asp Phe Phe Leu Ser Leu Val Ala Val Pro 
1               5                   10                  15      


Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala Thr Asn Gly Gln Pro 
            20                  25                  30          


Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu Ser Ile Ser Ser Arg 
        35                  40                  45              


Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser Gln Gly Gly Leu Gln 
    50                  55                  60                  


Thr Val Met Lys Trp Lys Thr Val Val Ala Ile Phe Val Val Val Val 
65                  70                  75                  80  


Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg Ala Leu Glu Gln Pro 
                85                  90                  95      


Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu Glu Lys Ala Glu Phe 
            100                 105                 110         


Leu Arg Asp His Val Cys Val Ser Pro Gln Glu Leu Glu Thr Leu Ile 
        115                 120                 125             


Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val Ser Pro Ile Gly Asn 
    130                 135                 140                 


Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly Ser Ala Phe Phe Phe 
145                 150                 155                 160 


Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly Asn Ile Ala Pro Ser 
                165                 170                 175     


Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr Ala Ile Phe Gly Ile 
            180                 185                 190         


Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly Asp Gln Leu Gly Thr 
        195                 200                 205             


Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys Val Phe Arg Lys Lys 
    210                 215                 220                 


Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser Thr Ile Leu Phe Ile 
225                 230                 235                 240 


Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro Ala Val Ile Phe Lys 
                245                 250                 255     


Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile Tyr Phe Val Val Val 
            260                 265                 270         


Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val Ala Gly Gly Asn Ala 
        275                 280                 285             


Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu Val Trp Phe Trp Ile 
    290                 295                 300                 


Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly Asp 
305                 310                 315                 320 


Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu Glu Val Gly Glu Ile 
                325                 330                 335     


Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val Thr Ala Glu Phe Arg 
            340                 345                 350         


Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His Asp Lys Leu Gln Arg 
        355                 360                 365             


Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg Leu Gly Leu Asp Gln 
    370                 375                 380                 


Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu Lys Arg Ser Val Phe 
385                 390                 395                 400 


Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser Ser Gln Glu Ser Ile 
                405                 410                 415     


Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly Pro Glu Gln Leu Asn 
            420                 425                 430         


Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile Ile Asn Lys Phe Gly 
        435                 440                 445             


Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys Asp Leu Lys Lys Thr 
    450                 455                 460                 


Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr Phe Arg Asn Tyr Ser 
465                 470                 475                 480 


Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu Lys Met Cys Asn Ser 
                485                 490                 495     


Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys Ile Gln Gln His Ala 
            500                 505                 510         


Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr Lys Asp Arg Glu Pro 
        515                 520                 525             


Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535             


<210>  547
<211>  2484
<212>  DNA
<213>  Homosapiens

<400>  547
tgcaaacacc caagccctct ccagttctcc cccaagctaa tattttccca cctgtctttt     60

tctggggttc ctccacgagc cagtccaagg ctcccccatc ctcggaaatt gttttgttgg    120

actgctaaac cgaggcgtgt aaagcttgag gactttatta ttatttgggt tcttttcatt    180

tcttcccctt ctgggcaacg aagcaatgaa atttccaatc gagacgccaa gaaaacaggt    240

gaactgggat cctaaagtgg ccgttcccgc agcagcaccg gtgtgccagc ccaagagcgc    300

cactaacggg caacccccgg ctccggctcc gactccaact ccgcgcctgt ccatttcctc    360

ccgagccaca gtggtagcca ggatggaagg cacctcccaa gggggcttgc agaccgtcat    420

gaagtggaag acggtggttg ccatctttgt ggttgtggtg gtctaccttg tcactggcgg    480

tcttgtcttc cgggcattgg agcagccctt tgagagcagc cagaagaata ccatcgcctt    540

ggagaaggcg gaattcctgc gggatcatgt ctgtgtgagc ccccaggagc tggagacgtt    600

gatccagcat gctcttgatg ctgacaatgc gggagtcagt ccaataggaa actcttccaa    660

caacagcagc cactgggacc tcggcagtgc ctttttcttt gctggaactg tcattacgac    720

catagggtat gggaatattg ctccgagcac tgaaggaggc aaaatctttt gtattttata    780

tgccatcttt ggaattccac tctttggttt cttattggct ggaattggag accaacttgg    840

aaccatcttt gggaaaagca ttgcaagagt ggagaaggtc tttcgaaaaa agcaagtgag    900

tcagaccaag atccgggtca tctcaaccat cctgttcatc ttggccggct gcattgtgtt    960

tgtgacgatc cctgctgtca tctttaagta catcgagggc tggacggcct tggagtccat   1020

ttactttgtg gtggtcactc tgaccacggt gggctttggt gattttgtgg cagggggaaa   1080

cgctggcatc aattatcggg agtggtataa gcccctagtg tggttttgga tccttgttgg   1140

ccttgcctac tttgcagctg tcctcagtat gatcggagat tggctacggg ttctgtccaa   1200

aaagacaaaa gaagaggtgg gtgaaatcaa ggcccatgcg gcagagtgga aggccaatgt   1260

cacggctgag ttccgggaga cacggcgaag gctcagcgtg gagatccacg ataagctgca   1320

gcgggcggcc accatccgca gcatggagcg ccggcggctg ggcctggacc agcgggccca   1380

ctcactggac atgctgtccc ccgagaagcg ctctgtcttt gctgccctgg acaccggccg   1440

cttcaaggcc tcatcccagg agagcatcaa caaccggccc aacaacctgc gcctgaaggg   1500

gccggagcag ctgaacaagc atgggcaggg tgcgtccgag gacaacatca tcaacaagtt   1560

cgggtccacc tccagactca ccaagaggaa aaacaaggac ctcaaaaaga ccttgcccga   1620

ggacgttcag aaaatctaca agaccttccg gaattactcc ctggacgagg agaagaaaga   1680

ggaggagacg gaaaagatgt gtaactcaga caactccagc acagccatgc tgacggactg   1740

tatccagcag cacgctgagt tggagaacgg aatgataccc acggacacca aagaccggga   1800

gccggagaac aactcattac ttgaagacag aaactaaatg tgaaggacat tggtcttgga   1860

ctgagcgttg tgtgtgtgtg tgtgtgtgtt tttaatattc acactgagac atgtgcctta   1920

aacagacttt ttagtccaaa attacatagc attgaagaat atatttcact gtgccataaa   1980

caactgaaag cttgctctgc caaaaggaat cagagaacaa gaacttcatt tcagatagca   2040

aacgcaggac acaccaagag tgtccgtgca cgtagccggt tctggccgta catgttaagg   2100

gcatttcagt ggcagtgctg tacccctggg cagtgctacc tgggcacaca cgtagacaag   2160

ggcagctatt ccttagacca gcctcctgaa agaaacaggt gtgtcttttt agtggagtcg   2220

tagtaatatg tgcacacaca gaaggggacc tgattgggtg ggagctggtt atgtgtaact   2280

agcgttggag ttgacatttt ggcatgtgct ctgagcttga attttgatac caaccattca   2340

gtgcatcata cctagtcttt ctatgctcca aatgaatgtc tgtggggacc tgagagcacc   2400

tggaatttgt tggaagcaga tcagagcaca cgtacgaaaa ggtgcaattg cttttctcat   2460

gacaaaagaa aaaaaaaaaa aaaa                                          2484


<210>  548
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  548

Met Lys Phe Pro Ile Glu Thr Pro Arg Lys Gln Val Asn Trp Asp Pro 
1               5                   10                  15      


Lys Val Ala Val Pro Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala 
            20                  25                  30          


Thr Asn Gly Gln Pro Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu 
        35                  40                  45              


Ser Ile Ser Ser Arg Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser 
    50                  55                  60                  


Gln Gly Gly Leu Gln Thr Val Met Lys Trp Lys Thr Val Val Ala Ile 
65                  70                  75                  80  


Phe Val Val Val Val Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg 
                85                  90                  95      


Ala Leu Glu Gln Pro Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu 
            100                 105                 110         


Glu Lys Ala Glu Phe Leu Arg Asp His Val Cys Val Ser Pro Gln Glu 
        115                 120                 125             


Leu Glu Thr Leu Ile Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val 
    130                 135                 140                 


Ser Pro Ile Gly Asn Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly 
145                 150                 155                 160 


Ser Ala Phe Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly 
                165                 170                 175     


Asn Ile Ala Pro Ser Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr 
            180                 185                 190         


Ala Ile Phe Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly 
        195                 200                 205             


Asp Gln Leu Gly Thr Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys 
    210                 215                 220                 


Val Phe Arg Lys Lys Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser 
225                 230                 235                 240 


Thr Ile Leu Phe Ile Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro 
                245                 250                 255     


Ala Val Ile Phe Lys Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile 
            260                 265                 270         


Tyr Phe Val Val Val Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val 
        275                 280                 285             


Ala Gly Gly Asn Ala Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu 
    290                 295                 300                 


Val Trp Phe Trp Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu 
305                 310                 315                 320 


Ser Met Ile Gly Asp Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu 
                325                 330                 335     


Glu Val Gly Glu Ile Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val 
            340                 345                 350         


Thr Ala Glu Phe Arg Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His 
        355                 360                 365             


Asp Lys Leu Gln Arg Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg 
    370                 375                 380                 


Leu Gly Leu Asp Gln Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu 
385                 390                 395                 400 


Lys Arg Ser Val Phe Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser 
                405                 410                 415     


Ser Gln Glu Ser Ile Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly 
            420                 425                 430         


Pro Glu Gln Leu Asn Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile 
        435                 440                 445             


Ile Asn Lys Phe Gly Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys 
    450                 455                 460                 


Asp Leu Lys Lys Thr Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr 
465                 470                 475                 480 


Phe Arg Asn Tyr Ser Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu 
                485                 490                 495     


Lys Met Cys Asn Ser Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys 
            500                 505                 510         


Ile Gln Gln His Ala Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr 
        515                 520                 525             


Lys Asp Arg Glu Pro Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535                 540             


<210>  549
<211>  692
<212>  DNA
<213>  Homosapiens

<400>  549
gtggatacaa agtgaaaacg gaatattgaa gagatgggga aatggtgtga cctgcagttg     60

ccaattcatg atttgatggc ttcgaggctc agcctcagtg ctatagtact gacaaggaag    120

ctgaggtttg gaggttaagc gacttgtcgc ctgctgatga gtgatgacaa tcaggctgtc    180

tgcctcgggc cacaccctga ggctgctagg cagtgtctgc tgagacaagg ccaaggcggg    240

ctgctcgctc tgggcagacc cactgggggc ctgtggagct gtctgcagtc agcagagctg    300

gtagtgagct ctctctcccc agcggggaag tcatcaagaa atctcccatt ttcatcttcc    360

tgcaggcacg tctccctaga gaggagtctc cctgggagga tgctaggtcc cctgtggacc    420

ctgggagttc ctggaggatg tccctgctcc gtgactactg gcgaagttcc tccggggtta    480

tccggtcctc gccaagccca cctcttgcct ttcatttcaa ctctgaaata tgcaccaggc    540

aaattccaca aacattgacg gaacccttgc caaggtccag aaccatgttg aggaattggt    600

ccacatttcc tcatttaacc ctactgtaat cctcagaggc cactttatca tttccatttt    660

atagaaatcc agaggagtga agaggactgt tc                                  692


<210>  550
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  550

Met Ser Asp Asp Asn Gln Ala Val Cys Leu Gly Pro His Pro Glu Ala 
1               5                   10                  15      


Ala Arg Gln Cys Leu Leu Arg Gln Gly Gln Gly Gly Leu Leu Ala Leu 
            20                  25                  30          


Gly Arg Pro Thr Gly Gly Leu Trp Ser Cys Leu Gln Ser Ala Glu Leu 
        35                  40                  45              


Val Val Ser Ser Leu Ser Pro Ala Gly Lys Ser Ser Arg Asn Leu Pro 
    50                  55                  60                  


Phe Ser Ser Ser Cys Arg His Val Ser Leu Glu Arg Ser Leu Pro Gly 
65                  70                  75                  80  


Arg Met Leu Gly Pro Leu Trp Thr Leu Gly Val Pro Gly Gly Cys Pro 
                85                  90                  95      


Cys Ser Val Thr Thr Gly Glu Val Pro Pro Gly Leu Ser Gly Pro Arg 
            100                 105                 110         


Gln Ala His Leu Leu Pro Phe Ile Ser Thr Leu Lys Tyr Ala Pro Gly 
        115                 120                 125             


Lys Phe His Lys His 
    130             


<210>  551
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  551
atggtggccc tgtccttaaa gatttgtgtg cgccactgca acgtggtgaa gaccatgcag     60

tttgaaccat ctacagctgt gtacgatgcg tgtcgagtca ttcgggaacg ggtgcctgag    120

gcacaaactg ggcaagcttc tgactatgga ctctttcttt cggatgaaga cccgaggaaa    180

gggatttggc tggaagcggg cagaacactg gattactaca tgttgcggaa tggggatatt    240

ttggaatata aaaagaaaca gagacctcag aaaatccgga tgctggatgg atctgtgaag    300

acagtgatgg tggatgattc caagactgtg ggggagctcc tggtcactat ttgtagcaga    360

ataggaataa caaattatga agaatactcc ttaatccaag aaactattga agaaaagaaa    420

gaggaaggaa cgggcacact caaaaaagac aggacactgt tacgagatga gaggaaaatg    480

gagaagttga aggccaagct gcacacagat gatgacctaa attggctgga tcacagccga    540

acattcagag aacaaggagt agatgaaaac gaaacgttgc tgcttagacg gaagttcttt    600

tactctgatc agaatgtaga ttcgagagac cccgtgcagc tgaacttgct ttatgttcag    660

gcacgggatg acatcctgaa tggctctcac cctgtctcct tcgagaaagc ttgtgagttt    720

ggtggatttc aagcccagat acaatttgga cctcatgtgg aacataaaca caaacctgga    780

tttttagacc tgaaggaatt cctgcccaaa gaatatatca agcagagagg agctgaaaag    840

aggatctttc aggcacataa gaactgcgga gagatgagtg agatagaagc caaggtcaag    900

tacgtcaaac tcgcacggtc cctccgcaca tatggcgtgt ccttcttcct ggtgaaggag    960

aagatgaaag gcaagaacaa gctggtgcct cgcctgctgg ggatcaccaa agactcggtg   1020

atgcgcgtgg atgagaagac caaggaagtg ctgcaggagt ggcccctcac caccgtcaag   1080

cgctgggcag cctcacccaa gagcttcaca ctggattttg gggagtatca ggaaagctac   1140

tattcagtac aaaccaccga gggagagcag atatcccagc tgattgcagg ctacattgac   1200

atcatcctga aaaagaaaca aagtaaagat cgatttggac tagaaggtga tgaggagtca   1260

accatgttag aagagtccgt ttccccaaaa aagtccacca tcttgcagca gcagttcaac   1320

cggaccggga aggcagagca cggctcagtg gcgctgccgg ccgtgatgcg ctcgggctcc   1380

agcgggcctg agaccttcaa cgttggcagc atgccctcgc cacagcagca ggtcatggtt   1440

gggcagatgc accgaggcca catgccgcca ctgacttcag cccagcaggc cctgatgggg   1500

accatcaaca caagcatgca cgccgtccag caggcccagg atgatctcag tgagctcgac   1560

tcgctgccac ctctcggcca ggatatggca tctagggtat gggttcagaa caaagtcgac   1620

gaatccaaac acgaaatcca ttctcaagtt gatgctatca cggccggaac ggcttcagtt   1680

gttaacctca cagctggtga ccctgcagac actgactaca cagctgtggg atgtgcgatc   1740

accactattt cttccaacct gacggagatg tccaagggtg tgaagctatt ggccgccctc   1800

atggatgatg aggtgggcag cggggaggac ttgctcagag ctgccaggac cctcgctggg   1860

gcggtgtcag acttgctgaa agctgtgcag cctacttctg gagagcctcg acagacagtt   1920

ttgactgctg ctggcagcat cggacaagcc agtggggatc ttctgagaca gattggagag   1980

aatgagactg atgagcgatt ccaggatgtt ttaatgagtt tggccaaagc tgttgccaat   2040

gcagctgcca tgttggtact aaaggcaaag aatgttgccc aagtggccga agacactgtc   2100

ctacagaaca gggtaattgc tgctgccacc cagtgtgccc tctccacctc ccagcttgtg   2160

gcatgtgcca aggttgtgag ccccactatt agctcccctg tgtgccagga gcagctgatt   2220

gaagcaggga agctggtgga ccgctcggtg gagaactgtg tccgtgcctg ccaggcggcc   2280

actaccgata gtgagctcct gaagcaggtc agcgcagcgg ccagcgtggt cagccaggcc   2340

ctccatgatc tcctgcagca tgtgcggcag tttgccagcc gaggcgagcc catcggccgc   2400

tacgaccagg ctactgacac catcatgtgt gtcaccgaga gcatcttcag ctccatgggt   2460

gacgctggtg aaatggtgcg ccaggcgcgg gttctggccc aagccacatc agacctcgtc   2520

aatgccatga ggtcagatgc agaagccgaa atcgacatgg agaattcaaa gaagctcctg   2580

gcagcagcaa aactcttagc tgactccact gctcgcatgg tggaagctgc aaagggggct   2640

gcagccaacc cagagaatga ggaccagcag caaaggctga gagaagctgc agaaggcctc   2700

cgggtagcaa ccaacgcagc tgcccagaat gctattaaga aaaaaattgt caaccgactg   2760

gaggttgcag ccaagcaggc cgcagcggca gctacacaga ccatcgccgc ctcccagaat   2820

gcagctgttt ccaacaagaa ccctgcggcc cagcagcagc tggtccagag ttgcaaggca   2880

gtggctgatc acatccctca gctggtccag ggagtgaggg ggagccaagc tcaagctgaa   2940

gacctgagtg cccagctggc tctcatcatc tccagccaga acttcctcca gcctggaagc   3000

aagatggtgt cctctgccaa agccgcagtg cccaccgtga gtgaccaggc cgcagccatg   3060

cagctgagcc agtgtgccaa gaacctggcc accagcttgg cggagctgcg taccgcctcg   3120

cagaaggccc atgaagcttg tggtccgatg gaaatcgatt cagctctgaa tacggtgcag   3180

acgcttaaga atgaactgca ggatgccaag atggcagccg tggagagcca gctgaagcca   3240

cttccagggg aaacgctgga aaaatgtgct caggacctgg gaagcacatc caaggcggtg   3300

ggctcctcca tggcacagct gctgacctgt gctgctcaag gcaacgaaca ctacacaggg   3360

gtggctgcta gagagacggc ccaagctctg aaaacactgg cccaggccgc ccgtggagtg   3420

gctgcatcga caaccgaccc cgcggccgcc catgccatgt tagattctgc tcgagacgtg   3480

atggagggct ccgccatgct cattcaagag gccaagcagg ccctgattgc acctggagat   3540

gcagagcgtc aacaaagact ggctcaggtg gctaaagccg tctcacactc cttgaataac   3600

tgcgtaaatt gcctccctgg gcagaaggat gtggacgtgg ccttgaagag catcggggag   3660

tccagcaaga agctgcttgt ggattcgcta cctccaagca cgaagccttt ccaggaagcc   3720

cagagtgaac tgaaccaggc agcagctgat ctgaaccagt ctgctgggga agtggtccat   3780

gccacccggg gccagagtgg agagttggct gcagcctctg gaaagttcag tgatgatttt   3840

gatgaattcc tcgatgctgg cattgagatg gctggccaag ctcagacaaa agaagaccag   3900

atccaagtga tagggaacct caagaatatc tcgatggcat ccagcaagct gctgttagct   3960

gccaagtctc tctctgtaga tccaggagct cccaatgcga aaaatctcct ggctgcagct   4020

gcaagagctg tgacagagag catcaatcaa ctcatcactc tgtgtaccca acaagctccg   4080

ggccagaaag agtgcgataa tgccctgcgg gagctcgaga ctgtgaaggg gatgttggac   4140

aatcctaatg aacctgttag tgacctctct tactttgact gcattgagag tgtgatggaa   4200

aactccaagg ttctgggtga atcgatggca gggatttcac agaatgccaa gaccggagac   4260

ctccctgcct ttggggaatg tgtggggatt gcatccaagg ctctctgtgg gctgacagag   4320

gctgcagccc aggctgcata cttggttggc atctctgatc caaacagcca ggcaggccac   4380

cagggcctgg tggaccccat ccagtttgcc agggctaacc aggccatcca gatggcatgc   4440

cagaacttgg tggaccctgg cagcagccca tcacaggtcc tgtcagccgc cacaattgtt   4500

gccaagcaca cgtcagcctt gtgtaatgcc tgccgcatcg cctcatccaa gacggccaac   4560

ccagtagcca agaggcactt cgtccagtca gccaaggaag tcgccaacag cactgccaac   4620

ctggtgaaga ccatcaaggc cctggatggg gatttctctg aagacaaccg caataagtgt   4680

cgcatcgcca ccgcaccctt gattgaagct gtggagaacc tgacagcgtt cgcctcaaac   4740

cctgagtttg tcagcattcc tgcccagatc agctccgagg gttcccaggc acaggaacca   4800

atcctggtct cagccaagac catgctggag agttcatcgt acctcattcg cactgcacgc   4860

tctctggcca tcaaccccaa agacccaccc acctggtctg tactggctgg acattcccat   4920

acagtgtccg actccatcaa gagtctcatc acttctatca gggacaaggc ccctggacag   4980

agggagtgtg attactccat cgatggcatc aaccggtgca tccgggacat cgagcaggcc   5040

tcgctggccg ccgtcagcca gagcctggcc acgagggacg acatctctgt ggaggccctg   5100

caggagcagc tgacttcggt ggtccaggaa atcggacacc ttatcgatcc catcgccaca   5160

gcggctcggg gagaagcagc tcagctggga cataaggtga cacaactggc aagctatttt   5220

gagcccttga tcttagccgc agttggtgtg gcctccaaga ttcttgatca tcagcagcag   5280

atgacggtgc tggaccagac caagactctc gcagagtctg ccttgcagat gttgtatgca   5340

gccaaagaag gtggcggaaa ccccaaggca caacacaccc atgacgccat cacagaggcc   5400

gcccagttga tgaaggaagc cgtggatgac atcatggtga cgctgaacga agctgccagt   5460

gaagtggggc tggttggggg catggtggac gccattgcag aagccatgag caagctggat   5520

gaaggcactc ctccagaacc aaagggaaca tttgtcgact atcagacgac tgtggttaaa   5580

tactccaaag ccattgcggt gacagctcag gaaatgatga ctaagtcggt tactaacccg   5640

gaggagttgg gaggactggc ttcacaaatg accagtgact atgggcacct ggctttccag   5700

ggccagatgg cagcagccac ggcggaacca gaggagatcg gattccagat tcgcactcgt   5760

gtgcaggacc tgggccacgg ctgtatcttc ctggtgcaga aggcaggggc cctccaggtc   5820

tgccccacag acagctacac caagagggag ctgatcgaat gcgcccgtgc cgtcacggaa   5880

aaggtctcct tggtgctctc ggctctccag gccgggaaca aaggaaccca ggcatgcatt   5940

acagccgcca ccgctgtgtc tgggatcatt gccgacctgg acaccaccat tatgtttgca   6000

acagcgggga cgctgaatgc agagaacagt gagaccttcg cagaccacag ggagaacatt   6060

ctcaagacgg ccaaggcctt ggtagaagac acgaaactac ttgtgtcagg agctgcgtcc   6120

actcctgaca agctggccca ggcggcccag tcctcagcag ccaccatcac ccagctcgca   6180

gaagtggtca agctgggggc agccagcctg ggctccgacg accccgagac ccaggtggtt   6240

ttgatcaatg ccatcaaaga tgtggccaag gccctttctg atctcatcag tgctaccaag   6300

ggagctgcca gcaagccagt ggacgaccct tccatgtacc agctcaaggg ggctgccaag   6360

gtgatggtga ccaatgtcac ctcgctcctc aagactgtaa aggcagtgga ggatgaggcc   6420

acccggggca ccagggcgct tgaggccaca attgaatgca taaagcagga gcttacggtg   6480

ttccagtcaa aagacgtacc tgaaaagaca tcatcacctg aagaatccat aaggatgacg   6540

aaaggcatca ccatggcaac agccaaagcc gtggcagctg ggaactcatg tagacaggag   6600

gacgtgattg ctactgccaa cctgagccgg aaagccgtgt cagatatgtt gacggcttgc   6660

aagcaagcat ccttccaccc cgatgtcagt gacgaggtga gaaccagagc cttgcgtttc   6720

gggacggagt gcacccttgg ctacttggac ctcctggagc acgtcttggt gattcttcag   6780

aaaccaaccc cagaattcaa gcagcagctg gccgctttct ccaagcgagt cgccggcgct   6840

gtgacagagc tcatccaggc ggcggaagcc atgaaaggaa cagagtgggt ggatccagaa   6900

gacccaactg tcattgcaga aacagagtta ctgggggctg cagcatccat cgaagctgct   6960

gctaagaagt tagagcaact gaagccaaga gcaaaaccaa aacaagcgga tgagaccctg   7020

gactttgagg aacagatctt ggaagctgct aaatccattg ctgctgccac aagcgccctg   7080

gtcaaatcgg cctcagcagc ccagagggag ctggtggccc aaggaaaggt gggctccatc   7140

cctgccaatg ctgcagacga cggacagtgg tcacaggggc tgatttctgc tgcccggatg   7200

gtggcggctg cgaccagcag tctctgtgag gcggccaatg cctccgttca gggacacgcc   7260

agcgaggaga agctcatctc atctgccaag caggtcgccg cttccacggc tcagctgctg   7320

gtggcctgca aggtgaaggc cgaccaggat tcagaggcca tgaggcggct acaggcggca   7380

ggaaatgctg tgaaaagagc ctcagacaat cttgtccgtg cagcccagaa ggcagctttt   7440

ggcaaagctg atgacgacga tgttgtagtg aaaaccaagt ttgtgggggg cattgctcag   7500

atcatcgccg cccaggaaga aatgctaaag aaagagcgag aactggaaga agcaaggaaa   7560

aaactggccc aaatccgcca gcagcagtat aagtttttac ccaccgagct gagggaagat   7620

gagggctaaa ggtgcgagcc cagatggcga gccccagggg atggccctgg ctgaactgga   7680

cagacagtgt tcctgagagg ctgggcactt agctggaaac cgcccacctc cctcccgggt   7740

gagcctggag ccctgcgtgc ttgttctcac atctctgtcc cgtcggcact ggctgcatga   7800

tcgtgatgtc acacggtaca atgtcctacc cacaactcct ctgccgcctc ccctcatgcc   7860

tcaccgtgtc tcaggagaga ggggtgcacg tttcatggac tgttaccaac aaagaaaagt   7920

cagtattatg ttgttctcag acactttggc ttttgttggt ccttctctta ggcctgctcc   7980

tggacctctt tatgatattg tgatagggaa aaaaatcatt gacgtcatag aatattcttc   8040

ttcctctcag gagaagacgg aagctggagt tggacatggt tcataaaagc cagaaacaca   8100

aacccgtgtg gactccggga gggtgactca ggtcctcctt ccatgtcttg agcactggct   8160

cacccagggg gtgaaaaatt cccgcccctg tt                                 8192


<210>  552
<211>  2542
<212>  PRT
<213>  Homosapiens

<400>  552

Met Val Ala Leu Ser Leu Lys Ile Cys Val Arg His Cys Asn Val Val 
1               5                   10                  15      


Lys Thr Met Gln Phe Glu Pro Ser Thr Ala Val Tyr Asp Ala Cys Arg 
            20                  25                  30          


Val Ile Arg Glu Arg Val Pro Glu Ala Gln Thr Gly Gln Ala Ser Asp 
        35                  40                  45              


Tyr Gly Leu Phe Leu Ser Asp Glu Asp Pro Arg Lys Gly Ile Trp Leu 
    50                  55                  60                  


Glu Ala Gly Arg Thr Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Lys Lys Lys Gln Arg Pro Gln Lys Ile Arg Met Leu Asp 
                85                  90                  95      


Gly Ser Val Lys Thr Val Met Val Asp Asp Ser Lys Thr Val Gly Glu 
            100                 105                 110         


Leu Leu Val Thr Ile Cys Ser Arg Ile Gly Ile Thr Asn Tyr Glu Glu 
        115                 120                 125             


Tyr Ser Leu Ile Gln Glu Thr Ile Glu Glu Lys Lys Glu Glu Gly Thr 
    130                 135                 140                 


Gly Thr Leu Lys Lys Asp Arg Thr Leu Leu Arg Asp Glu Arg Lys Met 
145                 150                 155                 160 


Glu Lys Leu Lys Ala Lys Leu His Thr Asp Asp Asp Leu Asn Trp Leu 
                165                 170                 175     


Asp His Ser Arg Thr Phe Arg Glu Gln Gly Val Asp Glu Asn Glu Thr 
            180                 185                 190         


Leu Leu Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser 
        195                 200                 205             


Arg Asp Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp 
    210                 215                 220                 


Ile Leu Asn Gly Ser His Pro Val Ser Phe Glu Lys Ala Cys Glu Phe 
225                 230                 235                 240 


Gly Gly Phe Gln Ala Gln Ile Gln Phe Gly Pro His Val Glu His Lys 
                245                 250                 255     


His Lys Pro Gly Phe Leu Asp Leu Lys Glu Phe Leu Pro Lys Glu Tyr 
            260                 265                 270         


Ile Lys Gln Arg Gly Ala Glu Lys Arg Ile Phe Gln Ala His Lys Asn 
        275                 280                 285             


Cys Gly Glu Met Ser Glu Ile Glu Ala Lys Val Lys Tyr Val Lys Leu 
    290                 295                 300                 


Ala Arg Ser Leu Arg Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu 
305                 310                 315                 320 


Lys Met Lys Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr 
                325                 330                 335     


Lys Asp Ser Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Leu Gln 
            340                 345                 350         


Glu Trp Pro Leu Thr Thr Val Lys Arg Trp Ala Ala Ser Pro Lys Ser 
        355                 360                 365             


Phe Thr Leu Asp Phe Gly Glu Tyr Gln Glu Ser Tyr Tyr Ser Val Gln 
    370                 375                 380                 


Thr Thr Glu Gly Glu Gln Ile Ser Gln Leu Ile Ala Gly Tyr Ile Asp 
385                 390                 395                 400 


Ile Ile Leu Lys Lys Lys Gln Ser Lys Asp Arg Phe Gly Leu Glu Gly 
                405                 410                 415     


Asp Glu Glu Ser Thr Met Leu Glu Glu Ser Val Ser Pro Lys Lys Ser 
            420                 425                 430         


Thr Ile Leu Gln Gln Gln Phe Asn Arg Thr Gly Lys Ala Glu His Gly 
        435                 440                 445             


Ser Val Ala Leu Pro Ala Val Met Arg Ser Gly Ser Ser Gly Pro Glu 
    450                 455                 460                 


Thr Phe Asn Val Gly Ser Met Pro Ser Pro Gln Gln Gln Val Met Val 
465                 470                 475                 480 


Gly Gln Met His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln 
                485                 490                 495     


Ala Leu Met Gly Thr Ile Asn Thr Ser Met His Ala Val Gln Gln Ala 
            500                 505                 510         


Gln Asp Asp Leu Ser Glu Leu Asp Ser Leu Pro Pro Leu Gly Gln Asp 
        515                 520                 525             


Met Ala Ser Arg Val Trp Val Gln Asn Lys Val Asp Glu Ser Lys His 
    530                 535                 540                 


Glu Ile His Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val 
545                 550                 555                 560 


Val Asn Leu Thr Ala Gly Asp Pro Ala Asp Thr Asp Tyr Thr Ala Val 
                565                 570                 575     


Gly Cys Ala Ile Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Lys 
            580                 585                 590         


Gly Val Lys Leu Leu Ala Ala Leu Met Asp Asp Glu Val Gly Ser Gly 
        595                 600                 605             


Glu Asp Leu Leu Arg Ala Ala Arg Thr Leu Ala Gly Ala Val Ser Asp 
    610                 615                 620                 


Leu Leu Lys Ala Val Gln Pro Thr Ser Gly Glu Pro Arg Gln Thr Val 
625                 630                 635                 640 


Leu Thr Ala Ala Gly Ser Ile Gly Gln Ala Ser Gly Asp Leu Leu Arg 
                645                 650                 655     


Gln Ile Gly Glu Asn Glu Thr Asp Glu Arg Phe Gln Asp Val Leu Met 
            660                 665                 670         


Ser Leu Ala Lys Ala Val Ala Asn Ala Ala Ala Met Leu Val Leu Lys 
        675                 680                 685             


Ala Lys Asn Val Ala Gln Val Ala Glu Asp Thr Val Leu Gln Asn Arg 
    690                 695                 700                 


Val Ile Ala Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val 
705                 710                 715                 720 


Ala Cys Ala Lys Val Val Ser Pro Thr Ile Ser Ser Pro Val Cys Gln 
                725                 730                 735     


Glu Gln Leu Ile Glu Ala Gly Lys Leu Val Asp Arg Ser Val Glu Asn 
            740                 745                 750         


Cys Val Arg Ala Cys Gln Ala Ala Thr Thr Asp Ser Glu Leu Leu Lys 
        755                 760                 765             


Gln Val Ser Ala Ala Ala Ser Val Val Ser Gln Ala Leu His Asp Leu 
    770                 775                 780                 


Leu Gln His Val Arg Gln Phe Ala Ser Arg Gly Glu Pro Ile Gly Arg 
785                 790                 795                 800 


Tyr Asp Gln Ala Thr Asp Thr Ile Met Cys Val Thr Glu Ser Ile Phe 
                805                 810                 815     


Ser Ser Met Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Val Leu 
            820                 825                 830         


Ala Gln Ala Thr Ser Asp Leu Val Asn Ala Met Arg Ser Asp Ala Glu 
        835                 840                 845             


Ala Glu Ile Asp Met Glu Asn Ser Lys Lys Leu Leu Ala Ala Ala Lys 
    850                 855                 860                 


Leu Leu Ala Asp Ser Thr Ala Arg Met Val Glu Ala Ala Lys Gly Ala 
865                 870                 875                 880 


Ala Ala Asn Pro Glu Asn Glu Asp Gln Gln Gln Arg Leu Arg Glu Ala 
                885                 890                 895     


Ala Glu Gly Leu Arg Val Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile 
            900                 905                 910         


Lys Lys Lys Ile Val Asn Arg Leu Glu Val Ala Ala Lys Gln Ala Ala 
        915                 920                 925             


Ala Ala Ala Thr Gln Thr Ile Ala Ala Ser Gln Asn Ala Ala Val Ser 
    930                 935                 940                 


Asn Lys Asn Pro Ala Ala Gln Gln Gln Leu Val Gln Ser Cys Lys Ala 
945                 950                 955                 960 


Val Ala Asp His Ile Pro Gln Leu Val Gln Gly Val Arg Gly Ser Gln 
                965                 970                 975     


Ala Gln Ala Glu Asp Leu Ser Ala Gln Leu Ala Leu Ile Ile Ser Ser 
            980                 985                 990         


Gln Asn Phe Leu Gln Pro Gly Ser  Lys Met Val Ser Ser  Ala Lys Ala 
        995                 1000                 1005             


Ala Val  Pro Thr Val Ser Asp  Gln Ala Ala Ala Met  Gln Leu Ser 
    1010                 1015                 1020             


Gln Cys  Ala Lys Asn Leu Ala  Thr Ser Leu Ala Glu  Leu Arg Thr 
    1025                 1030                 1035             


Ala Ser  Gln Lys Ala His Glu  Ala Cys Gly Pro Met  Glu Ile Asp 
    1040                 1045                 1050             


Ser Ala  Leu Asn Thr Val Gln  Thr Leu Lys Asn Glu  Leu Gln Asp 
    1055                 1060                 1065             


Ala Lys  Met Ala Ala Val Glu  Ser Gln Leu Lys Pro  Leu Pro Gly 
    1070                 1075                 1080             


Glu Thr  Leu Glu Lys Cys Ala  Gln Asp Leu Gly Ser  Thr Ser Lys 
    1085                 1090                 1095             


Ala Val  Gly Ser Ser Met Ala  Gln Leu Leu Thr Cys  Ala Ala Gln 
    1100                 1105                 1110             


Gly Asn  Glu His Tyr Thr Gly  Val Ala Ala Arg Glu  Thr Ala Gln 
    1115                 1120                 1125             


Ala Leu  Lys Thr Leu Ala Gln  Ala Ala Arg Gly Val  Ala Ala Ser 
    1130                 1135                 1140             


Thr Thr  Asp Pro Ala Ala Ala  His Ala Met Leu Asp  Ser Ala Arg 
    1145                 1150                 1155             


Asp Val  Met Glu Gly Ser Ala  Met Leu Ile Gln Glu  Ala Lys Gln 
    1160                 1165                 1170             


Ala Leu  Ile Ala Pro Gly Asp  Ala Glu Arg Gln Gln  Arg Leu Ala 
    1175                 1180                 1185             


Gln Val  Ala Lys Ala Val Ser  His Ser Leu Asn Asn  Cys Val Asn 
    1190                 1195                 1200             


Cys Leu  Pro Gly Gln Lys Asp  Val Asp Val Ala Leu  Lys Ser Ile 
    1205                 1210                 1215             


Gly Glu  Ser Ser Lys Lys Leu  Leu Val Asp Ser Leu  Pro Pro Ser 
    1220                 1225                 1230             


Thr Lys  Pro Phe Gln Glu Ala  Gln Ser Glu Leu Asn  Gln Ala Ala 
    1235                 1240                 1245             


Ala Asp  Leu Asn Gln Ser Ala  Gly Glu Val Val His  Ala Thr Arg 
    1250                 1255                 1260             


Gly Gln  Ser Gly Glu Leu Ala  Ala Ala Ser Gly Lys  Phe Ser Asp 
    1265                 1270                 1275             


Asp Phe  Asp Glu Phe Leu Asp  Ala Gly Ile Glu Met  Ala Gly Gln 
    1280                 1285                 1290             


Ala Gln  Thr Lys Glu Asp Gln  Ile Gln Val Ile Gly  Asn Leu Lys 
    1295                 1300                 1305             


Asn Ile  Ser Met Ala Ser Ser  Lys Leu Leu Leu Ala  Ala Lys Ser 
    1310                 1315                 1320             


Leu Ser  Val Asp Pro Gly Ala  Pro Asn Ala Lys Asn  Leu Leu Ala 
    1325                 1330                 1335             


Ala Ala  Ala Arg Ala Val Thr  Glu Ser Ile Asn Gln  Leu Ile Thr 
    1340                 1345                 1350             


Leu Cys  Thr Gln Gln Ala Pro  Gly Gln Lys Glu Cys  Asp Asn Ala 
    1355                 1360                 1365             


Leu Arg  Glu Leu Glu Thr Val  Lys Gly Met Leu Asp  Asn Pro Asn 
    1370                 1375                 1380             


Glu Pro  Val Ser Asp Leu Ser  Tyr Phe Asp Cys Ile  Glu Ser Val 
    1385                 1390                 1395             


Met Glu  Asn Ser Lys Val Leu  Gly Glu Ser Met Ala  Gly Ile Ser 
    1400                 1405                 1410             


Gln Asn  Ala Lys Thr Gly Asp  Leu Pro Ala Phe Gly  Glu Cys Val 
    1415                 1420                 1425             


Gly Ile  Ala Ser Lys Ala Leu  Cys Gly Leu Thr Glu  Ala Ala Ala 
    1430                 1435                 1440             


Gln Ala  Ala Tyr Leu Val Gly  Ile Ser Asp Pro Asn  Ser Gln Ala 
    1445                 1450                 1455             


Gly His  Gln Gly Leu Val Asp  Pro Ile Gln Phe Ala  Arg Ala Asn 
    1460                 1465                 1470             


Gln Ala  Ile Gln Met Ala Cys  Gln Asn Leu Val Asp  Pro Gly Ser 
    1475                 1480                 1485             


Ser Pro  Ser Gln Val Leu Ser  Ala Ala Thr Ile Val  Ala Lys His 
    1490                 1495                 1500             


Thr Ser  Ala Leu Cys Asn Ala  Cys Arg Ile Ala Ser  Ser Lys Thr 
    1505                 1510                 1515             


Ala Asn  Pro Val Ala Lys Arg  His Phe Val Gln Ser  Ala Lys Glu 
    1520                 1525                 1530             


Val Ala  Asn Ser Thr Ala Asn  Leu Val Lys Thr Ile  Lys Ala Leu 
    1535                 1540                 1545             


Asp Gly  Asp Phe Ser Glu Asp  Asn Arg Asn Lys Cys  Arg Ile Ala 
    1550                 1555                 1560             


Thr Ala  Pro Leu Ile Glu Ala  Val Glu Asn Leu Thr  Ala Phe Ala 
    1565                 1570                 1575             


Ser Asn  Pro Glu Phe Val Ser  Ile Pro Ala Gln Ile  Ser Ser Glu 
    1580                 1585                 1590             


Gly Ser  Gln Ala Gln Glu Pro  Ile Leu Val Ser Ala  Lys Thr Met 
    1595                 1600                 1605             


Leu Glu  Ser Ser Ser Tyr Leu  Ile Arg Thr Ala Arg  Ser Leu Ala 
    1610                 1615                 1620             


Ile Asn  Pro Lys Asp Pro Pro  Thr Trp Ser Val Leu  Ala Gly His 
    1625                 1630                 1635             


Ser His  Thr Val Ser Asp Ser  Ile Lys Ser Leu Ile  Thr Ser Ile 
    1640                 1645                 1650             


Arg Asp  Lys Ala Pro Gly Gln  Arg Glu Cys Asp Tyr  Ser Ile Asp 
    1655                 1660                 1665             


Gly Ile  Asn Arg Cys Ile Arg  Asp Ile Glu Gln Ala  Ser Leu Ala 
    1670                 1675                 1680             


Ala Val  Ser Gln Ser Leu Ala  Thr Arg Asp Asp Ile  Ser Val Glu 
    1685                 1690                 1695             


Ala Leu  Gln Glu Gln Leu Thr  Ser Val Val Gln Glu  Ile Gly His 
    1700                 1705                 1710             


Leu Ile  Asp Pro Ile Ala Thr  Ala Ala Arg Gly Glu  Ala Ala Gln 
    1715                 1720                 1725             


Leu Gly  His Lys Val Thr Gln  Leu Ala Ser Tyr Phe  Glu Pro Leu 
    1730                 1735                 1740             


Ile Leu  Ala Ala Val Gly Val  Ala Ser Lys Ile Leu  Asp His Gln 
    1745                 1750                 1755             


Gln Gln  Met Thr Val Leu Asp  Gln Thr Lys Thr Leu  Ala Glu Ser 
    1760                 1765                 1770             


Ala Leu  Gln Met Leu Tyr Ala  Ala Lys Glu Gly Gly  Gly Asn Pro 
    1775                 1780                 1785             


Lys Ala  Gln His Thr His Asp  Ala Ile Thr Glu Ala  Ala Gln Leu 
    1790                 1795                 1800             


Met Lys  Glu Ala Val Asp Asp  Ile Met Val Thr Leu  Asn Glu Ala 
    1805                 1810                 1815             


Ala Ser  Glu Val Gly Leu Val  Gly Gly Met Val Asp  Ala Ile Ala 
    1820                 1825                 1830             


Glu Ala  Met Ser Lys Leu Asp  Glu Gly Thr Pro Pro  Glu Pro Lys 
    1835                 1840                 1845             


Gly Thr  Phe Val Asp Tyr Gln  Thr Thr Val Val Lys  Tyr Ser Lys 
    1850                 1855                 1860             


Ala Ile  Ala Val Thr Ala Gln  Glu Met Met Thr Lys  Ser Val Thr 
    1865                 1870                 1875             


Asn Pro  Glu Glu Leu Gly Gly  Leu Ala Ser Gln Met  Thr Ser Asp 
    1880                 1885                 1890             


Tyr Gly  His Leu Ala Phe Gln  Gly Gln Met Ala Ala  Ala Thr Ala 
    1895                 1900                 1905             


Glu Pro  Glu Glu Ile Gly Phe  Gln Ile Arg Thr Arg  Val Gln Asp 
    1910                 1915                 1920             


Leu Gly  His Gly Cys Ile Phe  Leu Val Gln Lys Ala  Gly Ala Leu 
    1925                 1930                 1935             


Gln Val  Cys Pro Thr Asp Ser  Tyr Thr Lys Arg Glu  Leu Ile Glu 
    1940                 1945                 1950             


Cys Ala  Arg Ala Val Thr Glu  Lys Val Ser Leu Val  Leu Ser Ala 
    1955                 1960                 1965             


Leu Gln  Ala Gly Asn Lys Gly  Thr Gln Ala Cys Ile  Thr Ala Ala 
    1970                 1975                 1980             


Thr Ala  Val Ser Gly Ile Ile  Ala Asp Leu Asp Thr  Thr Ile Met 
    1985                 1990                 1995             


Phe Ala  Thr Ala Gly Thr Leu  Asn Ala Glu Asn Ser  Glu Thr Phe 
    2000                 2005                 2010             


Ala Asp  His Arg Glu Asn Ile  Leu Lys Thr Ala Lys  Ala Leu Val 
    2015                 2020                 2025             


Glu Asp  Thr Lys Leu Leu Val  Ser Gly Ala Ala Ser  Thr Pro Asp 
    2030                 2035                 2040             


Lys Leu  Ala Gln Ala Ala Gln  Ser Ser Ala Ala Thr  Ile Thr Gln 
    2045                 2050                 2055             


Leu Ala  Glu Val Val Lys Leu  Gly Ala Ala Ser Leu  Gly Ser Asp 
    2060                 2065                 2070             


Asp Pro  Glu Thr Gln Val Val  Leu Ile Asn Ala Ile  Lys Asp Val 
    2075                 2080                 2085             


Ala Lys  Ala Leu Ser Asp Leu  Ile Ser Ala Thr Lys  Gly Ala Ala 
    2090                 2095                 2100             


Ser Lys  Pro Val Asp Asp Pro  Ser Met Tyr Gln Leu  Lys Gly Ala 
    2105                 2110                 2115             


Ala Lys  Val Met Val Thr Asn  Val Thr Ser Leu Leu  Lys Thr Val 
    2120                 2125                 2130             


Lys Ala  Val Glu Asp Glu Ala  Thr Arg Gly Thr Arg  Ala Leu Glu 
    2135                 2140                 2145             


Ala Thr  Ile Glu Cys Ile Lys  Gln Glu Leu Thr Val  Phe Gln Ser 
    2150                 2155                 2160             


Lys Asp  Val Pro Glu Lys Thr  Ser Ser Pro Glu Glu  Ser Ile Arg 
    2165                 2170                 2175             


Met Thr  Lys Gly Ile Thr Met  Ala Thr Ala Lys Ala  Val Ala Ala 
    2180                 2185                 2190             


Gly Asn  Ser Cys Arg Gln Glu  Asp Val Ile Ala Thr  Ala Asn Leu 
    2195                 2200                 2205             


Ser Arg  Lys Ala Val Ser Asp  Met Leu Thr Ala Cys  Lys Gln Ala 
    2210                 2215                 2220             


Ser Phe  His Pro Asp Val Ser  Asp Glu Val Arg Thr  Arg Ala Leu 
    2225                 2230                 2235             


Arg Phe  Gly Thr Glu Cys Thr  Leu Gly Tyr Leu Asp  Leu Leu Glu 
    2240                 2245                 2250             


His Val  Leu Val Ile Leu Gln  Lys Pro Thr Pro Glu  Phe Lys Gln 
    2255                 2260                 2265             


Gln Leu  Ala Ala Phe Ser Lys  Arg Val Ala Gly Ala  Val Thr Glu 
    2270                 2275                 2280             


Leu Ile  Gln Ala Ala Glu Ala  Met Lys Gly Thr Glu  Trp Val Asp 
    2285                 2290                 2295             


Pro Glu  Asp Pro Thr Val Ile  Ala Glu Thr Glu Leu  Leu Gly Ala 
    2300                 2305                 2310             


Ala Ala  Ser Ile Glu Ala Ala  Ala Lys Lys Leu Glu  Gln Leu Lys 
    2315                 2320                 2325             


Pro Arg  Ala Lys Pro Lys Gln  Ala Asp Glu Thr Leu  Asp Phe Glu 
    2330                 2335                 2340             


Glu Gln  Ile Leu Glu Ala Ala  Lys Ser Ile Ala Ala  Ala Thr Ser 
    2345                 2350                 2355             


Ala Leu  Val Lys Ser Ala Ser  Ala Ala Gln Arg Glu  Leu Val Ala 
    2360                 2365                 2370             


Gln Gly  Lys Val Gly Ser Ile  Pro Ala Asn Ala Ala  Asp Asp Gly 
    2375                 2380                 2385             


Gln Trp  Ser Gln Gly Leu Ile  Ser Ala Ala Arg Met  Val Ala Ala 
    2390                 2395                 2400             


Ala Thr  Ser Ser Leu Cys Glu  Ala Ala Asn Ala Ser  Val Gln Gly 
    2405                 2410                 2415             


His Ala  Ser Glu Glu Lys Leu  Ile Ser Ser Ala Lys  Gln Val Ala 
    2420                 2425                 2430             


Ala Ser  Thr Ala Gln Leu Leu  Val Ala Cys Lys Val  Lys Ala Asp 
    2435                 2440                 2445             


Gln Asp  Ser Glu Ala Met Arg  Arg Leu Gln Ala Ala  Gly Asn Ala 
    2450                 2455                 2460             


Val Lys  Arg Ala Ser Asp Asn  Leu Val Arg Ala Ala  Gln Lys Ala 
    2465                 2470                 2475             


Ala Phe  Gly Lys Ala Asp Asp  Asp Asp Val Val Val  Lys Thr Lys 
    2480                 2485                 2490             


Phe Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Lys  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Thr  Glu Leu Arg 
    2525                 2530                 2535             


Glu Asp  Glu Gly 
    2540         


<210>  553
<211>  1294
<212>  DNA
<213>  Homosapiens

<400>  553
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggccaagt ccgacagctg gaagaacaat    780

taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagacgagct gtacgctcag aaactgaagt acaaagccat cagcgaggag ctggaccacg   1020

ctctcaacga tatgacttcc atgtaaacgt tcatccactc tgcctgctta caccctgccc   1080

tcatgctaat ataagtttct ttgcttcact tctcccaaga ctccctcgtc gagctggatg   1140

tcccacctct ctgagctctg catttgtcta ttctccagct gaccctggtt ctctctctta   1200

gcatcctgcc ttagagccag gcacacactg tgctttctat tgtacagaag ctcttcgttt   1260

cagtgtcaaa taaacactgt gtaagctaaa aaaa                               1294


<210>  554
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  554

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Met 
        275                 280                 


<210>  555
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  555
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggcaaatg tgccgagctt gaagaagaat    780

tgaaaactgt gacgaacaac ttgaagtcac tggaggctca ggctgagaag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  556
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  556

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  557
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  557
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctcga ggaggacatc gcggccaagg agaagttgct gcgggtgtcg gaggacgagc    360

gggaccgggt gctggaggag ctgcacaagg cggaggacag cctcctggcc gccgaagagg    420

ccgccgccaa ggctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggcaaatg tgccgagctt gaagaagaat    780

tgaaaactgt gacgaacaac ttgaagtcac tggaggctca ggctgagaag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  558
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  558

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Glu Asp Ile Ala Ala Lys Glu Lys 
        35                  40                  45              


Leu Leu Arg Val Ser Glu Asp Glu Arg Asp Arg Val Leu Glu Glu Leu 
    50                  55                  60                  


His Lys Ala Glu Asp Ser Leu Leu Ala Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  559
<211>  1246
<212>  DNA
<213>  Homosapiens

<400>  559
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggcaaatg tgccgagctt gaagaagaat    780

tgaaaactgt gacgaacaac ttgaagtcac tggaggctca ggctgagaag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagacgagct gtacgctcag aaactgaagt acaaagccat cagcgaggag ctggaccacg   1020

ctctcaacga tatgacttcc atataagttt ctttgcttca cttctcccaa gactccctcg   1080

tcgagctgga tgtcccacct ctctgagctc tgcatttgtc tattctccag ctgaccctgg   1140

ttctctctct tagcatcctg ccttagagcc aggcacacac tgtgctttct attgtacaga   1200

agctcttcgt ttcagtgtca aataaacact gtgtaagcta aaaaaa                  1246


<210>  560
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  560

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  561
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  561
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggccaagt ccgacagctg gaagaacaat    780

taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  562
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  562

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  563
<211>  1566
<212>  DNA
<213>  Homosapiens

<400>  563
ggggcgccgc catcgcacag agaggcctgg gcggggcgga ccggcgctgg gcagccagga     60

cagccgcggc agccgggtcc gcagggcagc agccggcctc tcccactgca gccctcccgc    120

ccgcctaccg tccggcgcga tggcggggag tagctcgctg gaggcggtgc gcaggaagat    180

ccggagcctg caggagcagg cggacgccgc tgaggagcgc gcgggcaccc tgcagcgcga    240

gctggaccac gagaggaagc tgagggagac cgctgaagcc gacgtagctt ctctgaacag    300

acgcatccag ctggttgagg aagagttgga tcgtgcccag gagcgtctgg caacagcttt    360

gcagaagctg gaggaagctg agaaggcagc agatgagagt gagagaggca tgaaagtcat    420

tgagagtcga gcccaaaaag atgaagaaaa aatggaaatt caggagatcc aactgaaaga    480

ggccaagcac attgctgaag atgccgaccg caaatatgaa gaggtggccc gtaagctggt    540

catcattgag agcgacctgg aacgtgcaga ggagcgggct gagctctcag aaggcaaatg    600

tgccgagctt gaagaagaat tgaaaactgt gacgaacaac ttgaagtcac tggaggctca    660

ggctgagaag tactcgcaga aggaagacag atatgaggaa gagatcaagg tcctttccga    720

caagctgaag gaggctgaga ctcgggctga gtttgcggag aggtcagtaa ctaaattgga    780

gaaaagcatt gatgacttag aagatcaact ctaccagcaa cttgagcaaa atcgccgcct    840

cactaatgaa ctaaagctgg ccctgaatga ggattaaact taagagtgaa aaaacttggg    900

ctgaattcta ggcgtggagc ccatgtgcag aaaatctaag actgtcctac cttcaactaa    960

tagagttgaa aacagttgct ttctgcagaa atgcaaatgc aaggaattgg ctgaaaggct   1020

ggccttgcct gcttgtttct ctatatggct ggaataatta cgttctcttt aatcacaaaa   1080

cagcttttat ggtagaatac ttatatcaat tcagcactgc tccttgaaat agcaggtcct   1140

cttgtttgaa ctgataaata atgaggagcc cccccaaaaa atgttttcta tttcctgaca   1200

gccatgagtc ctactttaag tatgtatata tatatatata tgtgtgtgtg tgtgtgtgtg   1260

tatatattcc tatcagatac tcatattcct aacttctaaa tatctggtat agtgtttgaa   1320

atatgattaa atgtacctat gcttgggcaa aatagctttt gaaaacagga actcatgcca   1380

gaagcccctg gttgtctgaa aggtatgctt tactcagtct aatggtgctg ttggagtctg   1440

gggagaatgt catgctaata aatagaacac tataaaaata ttaagagaat gtcctaatga   1500

agtgtgcatg aaacatgttg acaatttttt atgagcaaca gaaataaatc attttaaaag   1560

ttctca                                                              1566


<210>  564
<211>  245
<212>  PRT
<213>  Homosapiens

<400>  564

Met Ala Gly Ser Ser Ser Leu Glu Ala Val Arg Arg Lys Ile Arg Ser 
1               5                   10                  15      


Leu Gln Glu Gln Ala Asp Ala Ala Glu Glu Arg Ala Gly Thr Leu Gln 
            20                  25                  30          


Arg Glu Leu Asp His Glu Arg Lys Leu Arg Glu Thr Ala Glu Ala Asp 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser 
                85                  90                  95      


Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu 
            180                 185                 190         


Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu Glu Asp Gln Leu 
    210                 215                 220                 


Tyr Gln Gln Leu Glu Gln Asn Arg Arg Leu Thr Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Asp 
                245 


<210>  565
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  565
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctcga ggaggacatc gcggccaagg agaagttgct gcgggtgtcg gaggacgagc    360

gggaccgggt gctggaggag ctgcacaagg cggaggacag cctcctggcc gccgaagagg    420

ccgccgccaa ggctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggccaagt ccgacagctg gaagaacaat    780

taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  566
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  566

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Glu Asp Ile Ala Ala Lys Glu Lys 
        35                  40                  45              


Leu Leu Arg Val Ser Glu Asp Glu Arg Asp Arg Val Leu Glu Glu Leu 
    50                  55                  60                  


His Lys Ala Glu Asp Ser Leu Leu Ala Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  567
<211>  557
<212>  DNA
<213>  Homosapiens

<400>  567
cctcattctc ccctatggaa gaccttgtgt agcccttcat caggcgtgtg ttgtggcttt     60

gtcacactgt tttgtaatga tcgctttgca tgtcttttcc agctgactcc gccaccatct    120

cctgcctgga tgactgcagc agcatccttg ctggcctctc tgcttcctgc attgcctcct    180

ctgaatcttc aggatgccaa gtttgtggag gaacggagaa agcagctcca gaattacctg    240

cgcagcgtca tgaacaaagt catccagatg gtccccgagt tcgctgccag ccccaagaag    300

gagaccctca tccagctgat gcccttcttc gtgatgggat tacaggtcgg aatgtacgga    360

ttgtttcatt ttggggtaat gatggatcag ccacagccaa gccttacccg tgctgacgaa    420

tctccatgtg atcgtgtcct ttctccatgt gctgcccaca gaaagcagcg agactgctgt    480

ctcagctgga aagctgagcc tgagagattt ctggttaaaa aaaaataaaa aataaaaatc    540

tcctgcctaa ggaaata                                                   557


<210>  568
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  568

Met Thr Ala Ala Ala Ser Leu Leu Ala Ser Leu Leu Pro Ala Leu Pro 
1               5                   10                  15      


Pro Leu Asn Leu Gln Asp Ala Lys Phe Val Glu Glu Arg Arg Lys Gln 
            20                  25                  30          


Leu Gln Asn Tyr Leu Arg Ser Val Met Asn Lys Val Ile Gln Met Val 
        35                  40                  45              


Pro Glu Phe Ala Ala Ser Pro Lys Lys Glu Thr Leu Ile Gln Leu Met 
    50                  55                  60                  


Pro Phe Phe Val Met Gly Leu Gln Val Gly Met Tyr Gly Leu Phe His 
65                  70                  75                  80  


Phe Gly Val Met Met Asp Gln Pro Gln Pro Ser Leu Thr Arg Ala Asp 
                85                  90                  95      


Glu Ser Pro Cys Asp Arg Val Leu Ser Pro Cys Ala Ala His Arg Lys 
            100                 105                 110         


Gln Arg Asp Cys Cys Leu Ser Trp Lys Ala Glu Pro Glu Arg Phe Leu 
        115                 120                 125             


Val Lys Lys Lys 
    130         


<210>  569
<211>  4235
<212>  DNA
<213>  Homosapiens

<400>  569
cgaggagacc aagccgctgc tggggggcga cgtgtcggcc cccgaaggca cgaagatggg     60

cgccgtgccc tgccgccggg ctcttctgct ttgcaacggg atgaggtaca aactgctgca    120

ggagggcgac attcaggtct gtgtcatccg gcacccgcgg acctttctca gcaagatcct    180

cacctcgaaa ttcctgaggc gctgggagcc gcaccaccta acgctggccg acaacagcct    240

ggcgtccgcc acgccaactg ggtacatgga aaactcagtc tcctacagcg caattgaaga    300

cgttcagctg ctgtcctggg agaatgcccc gaagtactgt ttacagctca cgattcctgg    360

gggaactgtc ttactgcagg ctgccaatag ctacctgcga gaccagtggt tccattctct    420

gcaatggaag aaaaagattt acaaatataa gaaagtgctg agtaacccaa gccgctggga    480

agttgtcttg aaagagatcc ggaccctggt ggacatggcc ctgacatccc ccctgcagga    540

tgactccatc aaccaggccc cactggaaat cgtctcgaaa ctgctctcag agaacacaaa    600

cttgaccacc caggagcatg aaaacatcat tgtggcaatc gctcctttgc tggaaaacaa    660

ccacccacca ccagatctct gtgaattctt ttgcaagcac tgcagagagc ggccccggtc    720

catggtggtc atcgaggtgt tcacccccgt ggtgcagcga atcctcaagc ataacatgga    780

ctttgggaag tgcccgcgac tgaggctgtt tactcaggag tacatccttg ccttgaacga    840

gctcaacgcg gggatggaag tggtgaagaa gttcattcag agcatgcacg gccccacagg    900

gcactgcccc cacccccggg tcctgcccaa cctggtggcc gtgtgcctgg ctgccatcta    960

ctcctgctat gaagagttca tcaacagccg cgacaattcc ccaagcctga aggaaatccg   1020

gaacggctgc cagcagccgt gcgaccggaa gcccacttta cctctgcgcc ttctgcaccc   1080

cagcccggac ctggtgtctc aggaagccac gctgtctgag gcccggctca agtcggtggt   1140

cgtggcctcc agtgagatcc acgtggaggt ggaacgcacc agcactgcca agccggcgct   1200

gacggccagc gcaggcaacg acagcgagcc caacctcatc gactgcctca tggtcagccc   1260

cgcctgcagc accatgagca tcgagctggg cccccaggcc gaccgcacgc tcggctgcta   1320

cgtggaaatc ctcaagctgc tgtcagacta tgatgactgg agaccgtctc tggccagttt   1380

gcttcaaccc attccattcc ccaaagaagc tctcgcacat gagaagttca ccaaggaact   1440

gaagtacgtg attcagaggt tcgccgaaga ccccaggcaa gaggtccact catgcctgct   1500

gagcgtgcgg gccggcaaag atggctggtt ccagctctac agccccggag gggtggcctg   1560

cgacgatgac ggggagctgt tcgccagcat ggtgcacatc ctcatgggct cctgttacaa   1620

gaccaaaaaa ttcctgctct ccctggcaga aaacaagctg ggtccctgca tgctcctggc   1680

actgaggggg aaccagacca tggtggagat cctgtgcttg atgctggaat acaacatcat   1740

cgacaacaac gacacccaac tgcagatcat ctcaaccctg gagagcacag acgtggggaa   1800

gcgcatgtac gagcagctgt gtgaccggca gcgggagctg aaggagctgc aaaggaaagg   1860

cgggcccacc aggctaacac tgccctccaa gtccacagac gctgacttgg ctcgtttgct   1920

gagctccggc tccttcggaa acctggagaa cctcagtttg gccttcacca atgtaaccag   1980

tgcctgcgcc gagcacctca tcaaactgcc ttcgctcaag cagctgaacc tgtggtccac   2040

tcagtttgga gacgctggcc ttcggctcct gtcggaacac ctcaccatgc tccaggtgct   2100

gaacctgtgc gagaccccgg tcacagacgc tggcctgctg gccctgagct ccatgaagag   2160

tctctgcagt ttaaacatga acagcaccaa gctctcagct gacacctacg aagatctgaa   2220

ggccaagctt cccaatttga aggaagtgga cgtccgctac accgaagcct ggtgaagctc   2280

ccagctcaag gcaggaagac gtttgcaacc gcgacaaaat aactcttgac taacagccgc   2340

agagcagccg gtcctggggt cccaccctgg tgccctggct gtgagataga tggggagtct   2400

ttctgggggc ggagggggga gggggtgggg agggggccca caagcacgcc cagcccccgc   2460

cgaattcttt tagcttcgta attggaacct ttgacctgat ctaaagtgga ctttgtagca   2520

acaagaggag catcagcggg tcggggaggg gtttgggggt gggctggggg gtgggggacc   2580

ctttgtggat tttctttgcc tttgtgtttg atgccgtcgt gtgggaaaag tcaactccga   2640

tgccaccatt gcgggccgga cgaaggatgc tttcttccta gaggctccga gctgagctgc   2700

gaactcgccc cccgcccttg ggacaagaag acccagtcac atcactgcac ccgtcctgtg   2760

tcctcaccat tgctatgcaa agtgattctt gttgtacata agatttaaat aatgcaccta   2820

tttaagacat gttgacaaat tgcgggtctg ggacccgcct cttatttatg aagtctttga   2880

ccgtcccccc cgcccgaccc caccgccctc ccgcccccac ctggcgtgta gtactgtata   2940

aaccagtcag ctgtcgggtt agtggtagta ttattgttat ttttttaaag gaaacaaaca   3000

gacaacaaaa agaagaaaaa aaaaaagaac ctccttggaa aaattaattg ctttttcgta   3060

atggattctc tatgctaatg ctctctcgtc tgtctgtctg tctgcccact cccccaccca   3120

ccactgtgcg tttctgattt ccaaatgtct ccaactccct cacgaggtgg ggctcaggct   3180

ggaggaggag ggattaagat ccccttgctc cactaaggcc caagctcttt ctctcggcac   3240

cttttagact tgaatgggag gctgctaacc cgccctctcc agtccacccc ggtaaaagag   3300

ctgttcccca cccccaggga gctcctgtcc ctgtcagcct ttgctgtccc ctgtccccaa   3360

cggagactct gtcacccctg ggctccccct gccatcgtgt gcttcacgtg gccccatgca   3420

tgcccgcctc tctgcatggt ctcttgggaa aagagagatg tgtcgcctcc gccagtccga   3480

ctgccctccc caccccaccc ccgccacccc ccacatgtga ccactgcaac gaagacactc   3540

cttctgtccc cacctgctcc gaagacaaac caacctccgt ttcttttata aacagtcggc   3600

tttttcttaa taagccctca ctgtacagaa cagcccgttg atggtttatt tggggtcccc   3660

ctctcccccc agcccttttt tctgttggtt tagcacaaat acttccctcc tccggcacct   3720

ccaaacctac cccacagtca gtgtacttgt tttatatata tttaatctta ttcaatggaa   3780

accatgcttt tgtcgtttta tactttgcta ggtagacttt attacccccc cactatgccc   3840

tcattttttt aaaaaaggaa aaaaaaaaga aactgggttc cagtcttaat tcattttccg   3900

tgccaggttt tatttcgtgt gtgtgtgagt gtgttctgtt ttgtgttttg ttttttgttg   3960

ttgttttcag ttgtttggtt ttcttttctt tcccccctcc ggtcccatac ttcacagcac   4020

tctggtgcgg gaagaagcag aagcaaaaaa aataaaaata aaaaaataaa taaaaataaa   4080

aaaaataaaa aaggaaaaaa aaaaagaaga aacaagacat gccacctttc ccctcgcact   4140

gttgcttttc ctgatggtta atactactgt cacgtagctg tgtacaaaga gatgtgaaat   4200

actttcaggc aaaaataaac tgtaagtgac tcatc                              4235


<210>  570
<211>  739
<212>  PRT
<213>  Homosapiens

<400>  570

Met Gly Ala Val Pro Cys Arg Arg Ala Leu Leu Leu Cys Asn Gly Met 
1               5                   10                  15      


Arg Tyr Lys Leu Leu Gln Glu Gly Asp Ile Gln Val Cys Val Ile Arg 
            20                  25                  30          


His Pro Arg Thr Phe Leu Ser Lys Ile Leu Thr Ser Lys Phe Leu Arg 
        35                  40                  45              


Arg Trp Glu Pro His His Leu Thr Leu Ala Asp Asn Ser Leu Ala Ser 
    50                  55                  60                  


Ala Thr Pro Thr Gly Tyr Met Glu Asn Ser Val Ser Tyr Ser Ala Ile 
65                  70                  75                  80  


Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro Lys Tyr Cys Leu 
                85                  90                  95      


Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln Ala Ala Asn Ser 
            100                 105                 110         


Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp Lys Lys Lys Ile 
        115                 120                 125             


Tyr Lys Tyr Lys Lys Val Leu Ser Asn Pro Ser Arg Trp Glu Val Val 
    130                 135                 140                 


Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu Thr Ser Pro Leu 
145                 150                 155                 160 


Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile Val Ser Lys Leu 
                165                 170                 175     


Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His Glu Asn Ile Ile 
            180                 185                 190         


Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro Pro Pro Asp Leu 
        195                 200                 205             


Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro Arg Ser Met Val 
    210                 215                 220                 


Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile Leu Lys His Asn 
225                 230                 235                 240 


Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe Thr Gln Glu Tyr 
                245                 250                 255     


Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu Val Val Lys Lys 
            260                 265                 270         


Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys Pro His Pro Arg 
        275                 280                 285             


Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala Ile Tyr Ser Cys 
    290                 295                 300                 


Tyr Glu Glu Phe Ile Asn Ser Arg Asp Asn Ser Pro Ser Leu Lys Glu 
305                 310                 315                 320 


Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys Pro Thr Leu Pro 
                325                 330                 335     


Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser Gln Glu Ala Thr 
            340                 345                 350         


Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala Ser Ser Glu Ile 
        355                 360                 365             


His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro Ala Leu Thr Ala 
    370                 375                 380                 


Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp Cys Leu Met Val 
385                 390                 395                 400 


Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly Pro Gln Ala Asp 
                405                 410                 415     


Arg Thr Leu Gly Cys Tyr Val Glu Ile Leu Lys Leu Leu Ser Asp Tyr 
            420                 425                 430         


Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln Pro Ile Pro Phe 
        435                 440                 445             


Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys Glu Leu Lys Tyr 
    450                 455                 460                 


Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu Val His Ser Cys 
465                 470                 475                 480 


Leu Leu Ser Val Arg Ala Gly Lys Asp Gly Trp Phe Gln Leu Tyr Ser 
                485                 490                 495     


Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu Phe Ala Ser Met 
            500                 505                 510         


Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys Lys Phe Leu Leu 
        515                 520                 525             


Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu Leu Ala Leu Arg 
    530                 535                 540                 


Gly Asn Gln Thr Met Val Glu Ile Leu Cys Leu Met Leu Glu Tyr Asn 
545                 550                 555                 560 


Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile Ser Thr Leu Glu 
                565                 570                 575     


Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu Cys Asp Arg Gln 
            580                 585                 590         


Arg Glu Leu Lys Glu Leu Gln Arg Lys Gly Gly Pro Thr Arg Leu Thr 
        595                 600                 605             


Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg Leu Leu Ser Ser 
    610                 615                 620                 


Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala Phe Thr Asn Val 
625                 630                 635                 640 


Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro Ser Leu Lys Gln 
                645                 650                 655     


Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly Leu Arg Leu Leu 
            660                 665                 670         


Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu Cys Glu Thr Pro 
        675                 680                 685             


Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met Lys Ser Leu Cys 
    690                 695                 700                 


Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp Thr Tyr Glu Asp 
705                 710                 715                 720 


Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Asp Val Arg Tyr Thr 
                725                 730                 735     


Glu Ala Trp 
            


<210>  571
<211>  4128
<212>  DNA
<213>  Homosapiens

<400>  571
ggcttcttgg atgggctggg cgtgcatggc ataaccgttt gagaacaaca aaccaagccg     60

gccgggctgc cgctctgttt cctgcgagga gggaagttac agatctccgc cctggcgtcc    120

ggggaaggat gggacaggct gctgagccaa ctgggtacat ggaaaactca gtctcctaca    180

gcgcaattga agacgttcag ctgctgtcct gggagaatgc cccgaagtac tgtttacagc    240

tcacgattcc tgggggaact gtcttactgc aggctgccaa tagctacctg cgagaccagt    300

ggttccattc tctgcaatgg aagaaaaaga tttacaaata taagaaagtg ctgagtaacc    360

caagccgctg ggaagttgtc ttgaaagaga tccggaccct ggtggacatg gccctgacat    420

cccccctgca ggatgactcc atcaaccagg ccccactgga aatcgtctcg aaactgctct    480

cagagaacac aaacttgacc acccaggagc atgaaaacat cattgtggca atcgctcctt    540

tgctggaaaa caaccaccca ccaccagatc tctgtgaatt cttttgcaag cactgcagag    600

agcggccccg gtccatggtg gtcatcgagg tgttcacccc cgtggtgcag cgaatcctca    660

agcataacat ggactttggg aagtgcccgc gactgaggct gtttactcag gagtacatcc    720

ttgccttgaa cgagctcaac gcggggatgg aagtggtgaa gaagttcatt cagagcatgc    780

acggccccac agggcactgc ccccaccccc gggtcctgcc caacctggtg gccgtgtgcc    840

tggctgccat ctactcctgc tatgaagagt tcatcaacag ccgcgacaat tccccaagcc    900

tgaaggaaat ccggaacggc tgccagcagc cgtgcgaccg gaagcccact ttacctctgc    960

gccttctgca ccccagcccg gacctggtgt ctcaggaagc cacgctgtct gaggcccggc   1020

tcaagtcggt ggtcgtggcc tccagtgaga tccacgtgga ggtggaacgc accagcactg   1080

ccaagccggc gctgacggcc agcgcaggca acgacagcga gcccaacctc atcgactgcc   1140

tcatggtcag ccccgcctgc agcaccatga gcatcgagct gggcccccag gccgaccgca   1200

cgctcggctg ctacgtggaa atcctcaagc tgctgtcaga ctatgatgac tggagaccgt   1260

ctctggccag tttgcttcaa cccattccat tccccaaaga agctctcgca catgagaagt   1320

tcaccaagga actgaagtac gtgattcaga ggttcgccga agaccccagg caagaggtcc   1380

actcatgcct gctgagcgtg cgggccggca aagatggctg gttccagctc tacagccccg   1440

gaggggtggc ctgcgacgat gacggggagc tgttcgccag catggtgcac atcctcatgg   1500

gctcctgtta caagaccaaa aaattcctgc tctccctggc agaaaacaag ctgggtccct   1560

gcatgctcct ggcactgagg gggaaccaga ccatggtgga gatcctgtgc ttgatgctgg   1620

aatacaacat catcgacaac aacgacaccc aactgcagat catctcaacc ctggagagca   1680

cagacgtggg gaagcgcatg tacgagcagc tgtgtgaccg gcagcgggag ctgaaggagc   1740

tgcaaaggaa aggcgggccc accaggctaa cactgccctc caagtccaca gacgctgact   1800

tggctcgttt gctgagctcc ggctccttcg gaaacctgga gaacctcagt ttggccttca   1860

ccaatgtaac cagtgcctgc gccgagcacc tcatcaaact gccttcgctc aagcagctga   1920

acctgtggtc cactcagttt ggagacgctg gccttcggct cctgtcggaa cacctcacca   1980

tgctccaggt gctgaacctg tgcgagaccc cggtcacaga cgctggcctg ctggccctga   2040

gctccatgaa gagtctctgc agtttaaaca tgaacagcac caagctctca gctgacacct   2100

acgaagatct gaaggccaag cttcccaatt tgaaggaagt ggacgtccgc tacaccgaag   2160

cctggtgaag ctcccagctc aaggcaggaa gacgtttgca accgcgacaa aataactctt   2220

gactaacagc cgcagagcag ccggtcctgg ggtcccaccc tggtgccctg gctgtgagat   2280

agatggggag tctttctggg ggcggagggg ggagggggtg gggagggggc ccacaagcac   2340

gcccagcccc cgccgaattc ttttagcttc gtaattggaa cctttgacct gatctaaagt   2400

ggactttgta gcaacaagag gagcatcagc gggtcgggga ggggtttggg ggtgggctgg   2460

ggggtggggg accctttgtg gattttcttt gcctttgtgt ttgatgccgt cgtgtgggaa   2520

aagtcaactc cgatgccacc attgcgggcc ggacgaagga tgctttcttc ctagaggctc   2580

cgagctgagc tgcgaactcg ccccccgccc ttgggacaag aagacccagt cacatcactg   2640

cacccgtcct gtgtcctcac cattgctatg caaagtgatt cttgttgtac ataagattta   2700

aataatgcac ctatttaaga catgttgaca aattgcgggt ctgggacccg cctcttattt   2760

atgaagtctt tgaccgtccc ccccgcccga ccccaccgcc ctcccgcccc cacctggcgt   2820

gtagtactgt ataaaccagt cagctgtcgg gttagtggta gtattattgt tattttttta   2880

aaggaaacaa acagacaaca aaaagaagaa aaaaaaaaag aacctccttg gaaaaattaa   2940

ttgctttttc gtaatggatt ctctatgcta atgctctctc gtctgtctgt ctgtctgccc   3000

actcccccac ccaccactgt gcgtttctga tttccaaatg tctccaactc cctcacgagg   3060

tggggctcag gctggaggag gagggattaa gatccccttg ctccactaag gcccaagctc   3120

tttctctcgg caccttttag acttgaatgg gaggctgcta acccgccctc tccagtccac   3180

cccggtaaaa gagctgttcc ccacccccag ggagctcctg tccctgtcag cctttgctgt   3240

cccctgtccc caacggagac tctgtcaccc ctgggctccc cctgccatcg tgtgcttcac   3300

gtggccccat gcatgcccgc ctctctgcat ggtctcttgg gaaaagagag atgtgtcgcc   3360

tccgccagtc cgactgccct ccccacccca cccccgccac cccccacatg tgaccactgc   3420

aacgaagaca ctccttctgt ccccacctgc tccgaagaca aaccaacctc cgtttctttt   3480

ataaacagtc ggctttttct taataagccc tcactgtaca gaacagcccg ttgatggttt   3540

atttggggtc cccctctccc cccagccctt ttttctgttg gtttagcaca aatacttccc   3600

tcctccggca cctccaaacc taccccacag tcagtgtact tgttttatat atatttaatc   3660

ttattcaatg gaaaccatgc ttttgtcgtt ttatactttg ctaggtagac tttattaccc   3720

ccccactatg ccctcatttt tttaaaaaag gaaaaaaaaa agaaactggg ttccagtctt   3780

aattcatttt ccgtgccagg ttttatttcg tgtgtgtgtg agtgtgttct gttttgtgtt   3840

ttgttttttg ttgttgtttt cagttgtttg gttttctttt ctttcccccc tccggtccca   3900

tacttcacag cactctggtg cgggaagaag cagaagcaaa aaaaataaaa ataaaaaaat   3960

aaataaaaat aaaaaaaata aaaaaggaaa aaaaaaaaga agaaacaaga catgccacct   4020

ttcccctcgc actgttgctt ttcctgatgg ttaatactac tgtcacgtag ctgtgtacaa   4080

agagatgtga aatactttca ggcaaaaata aactgtaagt gactcatc                4128


<210>  572
<211>  679
<212>  PRT
<213>  Homosapiens

<400>  572

Met Gly Gln Ala Ala Glu Pro Thr Gly Tyr Met Glu Asn Ser Val Ser 
1               5                   10                  15      


Tyr Ser Ala Ile Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro 
            20                  25                  30          


Lys Tyr Cys Leu Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln 
        35                  40                  45              


Ala Ala Asn Ser Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp 
    50                  55                  60                  


Lys Lys Lys Ile Tyr Lys Tyr Lys Lys Val Leu Ser Asn Pro Ser Arg 
65                  70                  75                  80  


Trp Glu Val Val Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu 
                85                  90                  95      


Thr Ser Pro Leu Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile 
            100                 105                 110         


Val Ser Lys Leu Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His 
        115                 120                 125             


Glu Asn Ile Ile Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro 
    130                 135                 140                 


Pro Pro Asp Leu Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro 
145                 150                 155                 160 


Arg Ser Met Val Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile 
                165                 170                 175     


Leu Lys His Asn Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe 
            180                 185                 190         


Thr Gln Glu Tyr Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu 
        195                 200                 205             


Val Val Lys Lys Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys 
    210                 215                 220                 


Pro His Pro Arg Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala 
225                 230                 235                 240 


Ile Tyr Ser Cys Tyr Glu Glu Phe Ile Asn Ser Arg Asp Asn Ser Pro 
                245                 250                 255     


Ser Leu Lys Glu Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys 
            260                 265                 270         


Pro Thr Leu Pro Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser 
        275                 280                 285             


Gln Glu Ala Thr Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala 
    290                 295                 300                 


Ser Ser Glu Ile His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro 
305                 310                 315                 320 


Ala Leu Thr Ala Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp 
                325                 330                 335     


Cys Leu Met Val Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly 
            340                 345                 350         


Pro Gln Ala Asp Arg Thr Leu Gly Cys Tyr Val Glu Ile Leu Lys Leu 
        355                 360                 365             


Leu Ser Asp Tyr Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln 
    370                 375                 380                 


Pro Ile Pro Phe Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys 
385                 390                 395                 400 


Glu Leu Lys Tyr Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu 
                405                 410                 415     


Val His Ser Cys Leu Leu Ser Val Arg Ala Gly Lys Asp Gly Trp Phe 
            420                 425                 430         


Gln Leu Tyr Ser Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu 
        435                 440                 445             


Phe Ala Ser Met Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys 
    450                 455                 460                 


Lys Phe Leu Leu Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu 
465                 470                 475                 480 


Leu Ala Leu Arg Gly Asn Gln Thr Met Val Glu Ile Leu Cys Leu Met 
                485                 490                 495     


Leu Glu Tyr Asn Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile 
            500                 505                 510         


Ser Thr Leu Glu Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu 
        515                 520                 525             


Cys Asp Arg Gln Arg Glu Leu Lys Glu Leu Gln Arg Lys Gly Gly Pro 
    530                 535                 540                 


Thr Arg Leu Thr Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg 
545                 550                 555                 560 


Leu Leu Ser Ser Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala 
                565                 570                 575     


Phe Thr Asn Val Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro 
            580                 585                 590         


Ser Leu Lys Gln Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly 
        595                 600                 605             


Leu Arg Leu Leu Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu 
    610                 615                 620                 


Cys Glu Thr Pro Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met 
625                 630                 635                 640 


Lys Ser Leu Cys Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp 
                645                 650                 655     


Thr Tyr Glu Asp Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Asp 
            660                 665                 670         


Val Arg Tyr Thr Glu Ala Trp 
        675                 


<210>  573
<211>  5182
<212>  DNA
<213>  Homosapiens

<400>  573
cgcgctggcg ccatggcgga gcaggagagc ctggaattcg gcaaggcaga cttcgtgctg     60

atggacaccg tctccatgcc cgagttcatg gccaacctca ggctcagatt tgaaaaaggg    120

cgcatctata cgttcattgg agaagtcgtc gtttctgtga acccttacaa gttgttgaac    180

atctatggaa gagacacaat tgagcagtat aaaggccgtg agctgtatga gagaccgcct    240

cacctttttg ctattgcgga tgctgcttac aaggctatga agaggcgatc aaaagacact    300

tgtattgtga tatcagggga aagtggagct ggtaaaacgg aagccagtaa gtacattatg    360

cagtatattg cggccatcac caaccccagt cagagagcag aggttgaaag agtgaagaat    420

atgttgctta agtccaactg tgttttggaa gcttttggaa atgccaaaac caaccgtaat    480

gacaactcaa gcaggtttgg aaaatacatg gatatcaact ttgacttcaa gggtgaccct    540

attggtgggc atatcaataa ctacttacta gaaaagtctc gagtgattgt gcaacagcca    600

ggagaaagaa gctttcattc tttctatcag ctactccaag gaggttcaga acaaatgcta    660

cgctctctac atctccagaa atccctttca tcctacaact atattcatgt gggagctcaa    720

ttaaagtctt ctatcaatga tgctgccgaa ttcagagttg ttgctgatgc catgaaagtc    780

attggcttca aacctgagga gatccaaaca gtgtataaga ttttggctgc tattctgcac    840

ttgggaaatt taaaatttgt agtagatggt gacacgcctc ttattgagaa tggcaaagta    900

gtatctatca tagcagaatt gctctctact aagacagata tggttgagaa agcccttctt    960

taccggactg tggccacagg ccgtgacatc attgacaagc agcacacaga acaagaggcc   1020

agctacggca gagacgcctt tgccaaggca atatatgagc gccttttttg ttggatcgtt   1080

actcgcatca atgatattat tgaggtcaag aactatgaca ccacaatcca tgggaaaaac   1140

actgttattg gtgtcttgga tatctatggc tttgaaatct tcgacaacaa cagttttgaa   1200

caattctgta tcaattactg caatgagaaa ctgcagcagc tatttattca gctggttctg   1260

aagcaagaac aagaggaata ccagcgggaa gggatcccct ggaaacatat tgactacttc   1320

aacaatcaga tcattgttga cctcgtggag caacagcaca aagggatcat tgcaatcctt   1380

gatgatgctt gcatgaatgt cggcaaagtc accgatgaaa tgtttcttga agcacttaac   1440

agtaaattgg gcaaacacgc ccatttttcc agccgaaagc tctgtgcctc agacaaaatt   1500

ctggagtttg atcgagattt tcgaattcga cattatgcag gcgatgtagt ctattctgtc   1560

attggtttta ttgacaaaaa taaagatact ttatttcaag atttcaagcg ccttatgtat   1620

aacagttcaa atcctgtgct caagaatatg tggcctgaag gcaaactgag cattacagag   1680

gtgaccaagc gacctctgac tgctgctacc ttgtttaaga attctatgat tgctctagta   1740

gacaaccttg catcaaagga accatattac gttcgttgca tcaaacccaa tgacaagaaa   1800

tctccacaga tatttgatga tgaacgctgc cggcaccaag tagaatatct tggactactg   1860

gaaaatgtga gagtgcgtcg ggcaggattt gccttccgcc agacatacga gaagtttctt   1920

cacaggtata agatgatctc tgaattcacc tggcccaacc atgaccttcc ttcagacaaa   1980

gaggctgtca agaaactaat tgaacggtgt ggttttcagg atgatgtagc ttatgggaag   2040

accaaaattt tcattcgaac accccgaaca ttgtttacct tggaagaact ccgtgcccag   2100

atgctcataa ggattgtcct ctttctacaa aaggtgtggc ggggcaccct ggcccgcatg   2160

cggtacaaaa gaaccaaggc agctctgaca ataatcaggt actaccggcg ctacaaagtg   2220

aagtcgtaca tccacgaggt ggccagacgc ttccatggcg tcaagaccat gcgagactac   2280

gggaagcacg tgaagtggcc aagccctcct aaagttcttc gccgttttga ggaggccctg   2340

cagacgattt tcaatagatg gagagcatcc cagctcatca agagcattcc ggcctcagac   2400

ctgccccagg tcagggcaaa ggttgcagcc gtggaaatgt tgaagggtca aagggctgac   2460

ctcgggctcc agagggcctg ggagggcaac tatcttgctt caaagccaga tacacctcag   2520

acctcaggca cttttgtccc tgttgctaat gaattgaaac ggaaggacaa atacatgaat   2580

gtcctctttt cctgtcacgt ccgtaaggta aatcgattta gtaaggtgga agacagagca   2640

atttttgtca ctgaccgtca cctgtataaa atggatccca ctaaacagta caaggtgatg   2700

aagactatcc ctctatacaa tttgactggt ctgagtgtct ccaatggaaa ggaccaactt   2760

gtagtgttcc atacgaaaga caacaaagac ctcattgtct gcctcttcag caaacagcca   2820

acccatgaga gtcgaattgg agaacttgtt ggagtgctgg tgaatcattt caagagtgag   2880

aagcgccacc ttcaagtgaa cgtcaccaac ccagtacagt gcagcctgca cgggaagaag   2940

tgcaccgtct ccgtggagac gcggctcaac cagccccagc ccgacttcac caagaatcgc   3000

tcgggcttca tcctcagcgt gcccgggaac tgacgccccg cggaggcctg gcccggagcc   3060

cggccacact ccgagtcctg ggtcccagtc cagctgctgc ctcccaaccc atgcccgcta   3120

gaaacctgct gcgagggccc ctcccagagg agccccgccc ctgtaagatt tccttcctgg   3180

ttttctgcct ttggtatcat cttcctctgt ccttactgtc cacggtccct gttcaataag   3240

ccaaagaccc tggtgccccg cccagacccc tgggctgacg tccagaccaa tctcacccca   3300

gaggcaactg gatggtgcct ttagttggtg cggatgcccc gtggccaggt caagtcagag   3360

cacctggaca ggtgtcctcc ctgctgctga ccctgcagag ggaaggggtg gggatgcagg   3420

accccgctct gcgggagccc catagccacc tctcttgccc aaggtgagcc agccctgggg   3480

acccagctca gggaggctct gctcagagtt cggcggaccc accccaaccc aactcccagc   3540

cgccagccaa agccactggg tgagcagagt cacccacagg gccagcccct cagccaggag   3600

ccagtggcag gagcggaaca gcccatccag cagagtgagt ccatccttcc caggttctcc   3660

cctgggagac tccctttgcc accaaggccc ccaccagggc ctctgaccac cgctctggag   3720

aggacagtgt ggcatgctcc aaggatcatc ttacttaact cgcagcctgt ggctgtggtc   3780

ctcttataga tactttcacc gtttgcaggg ttgctaatca gatacctgct gtcaccacac   3840

ttgggtcagg aaccctaatg agaacgggga gctgccaggg tgagggcagc cctcagggtc   3900

ggccgctttc cctctggacc acctcccgct gcgtttccta ctcagagaaa cagcaagggc   3960

ggggtcaaga cacgggatga cgggaagcag gaagcggggc agcagcacag cgtggggtcc   4020

tggcactgca ggccaggcca ggatgcccac cccgccctct acacggcccc ttggggcctg   4080

cgcccgtgaa actggtgcca gggagcactg ccagcttgcc agtttctgcc cagcaaaagc   4140

acgtatgctt caggggcctt ctgagaccac cttccccact gagccccagc tgctgagaag   4200

gccttgaggg aagtagaggc tgggagcaaa tgccccatgc ggtgagagga tgaggggagc   4260

ctacgcctca ggcatgtggt gagaggatga gggggaggga gcccacgcct caggtggagt   4320

gggcagaggt gcaagagagg gatgtactga agcttcttcc cgtcctgcca cagacacttc   4380

tcctgccttc ccaccctgac ccggcagaac ccaccaagtg cctgtgtgca gcctcctgtg   4440

cctcacccag ggcctgaccc cagagtggtc ccaacaaccc ggtctcatgc ccactcccca   4500

tccctgcttc ccaaaaattg cactgtgtgc agtttgcaac aaagaatccc gctggcatcc   4560

tgtccttggg aaccctttct cattctccaa gcctggtcag ctgcctgcac aggcagaggt   4620

gccctcagcc caggttagca acactcatag ttttgccaat taccagtaga cactagtgga   4680

accatctaac tggaacttcc tctctccttc cacttatttc ctcaaacttg ttgctttaca   4740

ctagacacat gcaaatgtat gttttaaaca caccaaaaca gatcatgcca aatgagttgc   4800

ctgtcaaagg ctggagggca ggaggagggc ctgggtttgg gttctttcct cccagccttt   4860

ggatggtgcc ttgggcccct tagccccagc gccagggcct cccagctgag gccacaggac   4920

aagcactttt ttatgatgta ctaaaagcca cagtatgtgg caactgcaaa aggatcagga   4980

atttagggta tgatctcggt cacgtgtccc gggcgctgag gggaaaggaa gcgggcatga   5040

ttgtagacaa tgagggggtt ctcttgatgt aatgaaatgc aattttatgg tttggtgcaa   5100

aaactcctat tttccagtaa attaacttta tttctaaagc atattttgat ttgccatcaa   5160

gagcaataaa gcattaaatc tt                                            5182


<210>  574
<211>  1006
<212>  PRT
<213>  Homosapiens

<400>  574

Met Ala Glu Gln Glu Ser Leu Glu Phe Gly Lys Ala Asp Phe Val Leu 
1               5                   10                  15      


Met Asp Thr Val Ser Met Pro Glu Phe Met Ala Asn Leu Arg Leu Arg 
            20                  25                  30          


Phe Glu Lys Gly Arg Ile Tyr Thr Phe Ile Gly Glu Val Val Val Ser 
        35                  40                  45              


Val Asn Pro Tyr Lys Leu Leu Asn Ile Tyr Gly Arg Asp Thr Ile Glu 
    50                  55                  60                  


Gln Tyr Lys Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Phe Ala 
65                  70                  75                  80  


Ile Ala Asp Ala Ala Tyr Lys Ala Met Lys Arg Arg Ser Lys Asp Thr 
                85                  90                  95      


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110         


Lys Tyr Ile Met Gln Tyr Ile Ala Ala Ile Thr Asn Pro Ser Gln Arg 
        115                 120                 125             


Ala Glu Val Glu Arg Val Lys Asn Met Leu Leu Lys Ser Asn Cys Val 
    130                 135                 140                 


Leu Glu Ala Phe Gly Asn Ala Lys Thr Asn Arg Asn Asp Asn Ser Ser 
145                 150                 155                 160 


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175     


Ile Gly Gly His Ile Asn Asn Tyr Leu Leu Glu Lys Ser Arg Val Ile 
            180                 185                 190         


Val Gln Gln Pro Gly Glu Arg Ser Phe His Ser Phe Tyr Gln Leu Leu 
        195                 200                 205             


Gln Gly Gly Ser Glu Gln Met Leu Arg Ser Leu His Leu Gln Lys Ser 
    210                 215                 220                 


Leu Ser Ser Tyr Asn Tyr Ile His Val Gly Ala Gln Leu Lys Ser Ser 
225                 230                 235                 240 


Ile Asn Asp Ala Ala Glu Phe Arg Val Val Ala Asp Ala Met Lys Val 
                245                 250                 255     


Ile Gly Phe Lys Pro Glu Glu Ile Gln Thr Val Tyr Lys Ile Leu Ala 
            260                 265                 270         


Ala Ile Leu His Leu Gly Asn Leu Lys Phe Val Val Asp Gly Asp Thr 
        275                 280                 285             


Pro Leu Ile Glu Asn Gly Lys Val Val Ser Ile Ile Ala Glu Leu Leu 
    290                 295                 300                 


Ser Thr Lys Thr Asp Met Val Glu Lys Ala Leu Leu Tyr Arg Thr Val 
305                 310                 315                 320 


Ala Thr Gly Arg Asp Ile Ile Asp Lys Gln His Thr Glu Gln Glu Ala 
                325                 330                 335     


Ser Tyr Gly Arg Asp Ala Phe Ala Lys Ala Ile Tyr Glu Arg Leu Phe 
            340                 345                 350         


Cys Trp Ile Val Thr Arg Ile Asn Asp Ile Ile Glu Val Lys Asn Tyr 
        355                 360                 365             


Asp Thr Thr Ile His Gly Lys Asn Thr Val Ile Gly Val Leu Asp Ile 
    370                 375                 380                 


Tyr Gly Phe Glu Ile Phe Asp Asn Asn Ser Phe Glu Gln Phe Cys Ile 
385                 390                 395                 400 


Asn Tyr Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Val Leu 
                405                 410                 415     


Lys Gln Glu Gln Glu Glu Tyr Gln Arg Glu Gly Ile Pro Trp Lys His 
            420                 425                 430         


Ile Asp Tyr Phe Asn Asn Gln Ile Ile Val Asp Leu Val Glu Gln Gln 
        435                 440                 445             


His Lys Gly Ile Ile Ala Ile Leu Asp Asp Ala Cys Met Asn Val Gly 
    450                 455                 460                 


Lys Val Thr Asp Glu Met Phe Leu Glu Ala Leu Asn Ser Lys Leu Gly 
465                 470                 475                 480 


Lys His Ala His Phe Ser Ser Arg Lys Leu Cys Ala Ser Asp Lys Ile 
                485                 490                 495     


Leu Glu Phe Asp Arg Asp Phe Arg Ile Arg His Tyr Ala Gly Asp Val 
            500                 505                 510         


Val Tyr Ser Val Ile Gly Phe Ile Asp Lys Asn Lys Asp Thr Leu Phe 
        515                 520                 525             


Gln Asp Phe Lys Arg Leu Met Tyr Asn Ser Ser Asn Pro Val Leu Lys 
    530                 535                 540                 


Asn Met Trp Pro Glu Gly Lys Leu Ser Ile Thr Glu Val Thr Lys Arg 
545                 550                 555                 560 


Pro Leu Thr Ala Ala Thr Leu Phe Lys Asn Ser Met Ile Ala Leu Val 
                565                 570                 575     


Asp Asn Leu Ala Ser Lys Glu Pro Tyr Tyr Val Arg Cys Ile Lys Pro 
            580                 585                 590         


Asn Asp Lys Lys Ser Pro Gln Ile Phe Asp Asp Glu Arg Cys Arg His 
        595                 600                 605             


Gln Val Glu Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala 
    610                 615                 620                 


Gly Phe Ala Phe Arg Gln Thr Tyr Glu Lys Phe Leu His Arg Tyr Lys 
625                 630                 635                 640 


Met Ile Ser Glu Phe Thr Trp Pro Asn His Asp Leu Pro Ser Asp Lys 
                645                 650                 655     


Glu Ala Val Lys Lys Leu Ile Glu Arg Cys Gly Phe Gln Asp Asp Val 
            660                 665                 670         


Ala Tyr Gly Lys Thr Lys Ile Phe Ile Arg Thr Pro Arg Thr Leu Phe 
        675                 680                 685             


Thr Leu Glu Glu Leu Arg Ala Gln Met Leu Ile Arg Ile Val Leu Phe 
    690                 695                 700                 


Leu Gln Lys Val Trp Arg Gly Thr Leu Ala Arg Met Arg Tyr Lys Arg 
705                 710                 715                 720 


Thr Lys Ala Ala Leu Thr Ile Ile Arg Tyr Tyr Arg Arg Tyr Lys Val 
                725                 730                 735     


Lys Ser Tyr Ile His Glu Val Ala Arg Arg Phe His Gly Val Lys Thr 
            740                 745                 750         


Met Arg Asp Tyr Gly Lys His Val Lys Trp Pro Ser Pro Pro Lys Val 
        755                 760                 765             


Leu Arg Arg Phe Glu Glu Ala Leu Gln Thr Ile Phe Asn Arg Trp Arg 
    770                 775                 780                 


Ala Ser Gln Leu Ile Lys Ser Ile Pro Ala Ser Asp Leu Pro Gln Val 
785                 790                 795                 800 


Arg Ala Lys Val Ala Ala Val Glu Met Leu Lys Gly Gln Arg Ala Asp 
                805                 810                 815     


Leu Gly Leu Gln Arg Ala Trp Glu Gly Asn Tyr Leu Ala Ser Lys Pro 
            820                 825                 830         


Asp Thr Pro Gln Thr Ser Gly Thr Phe Val Pro Val Ala Asn Glu Leu 
        835                 840                 845             


Lys Arg Lys Asp Lys Tyr Met Asn Val Leu Phe Ser Cys His Val Arg 
    850                 855                 860                 


Lys Val Asn Arg Phe Ser Lys Val Glu Asp Arg Ala Ile Phe Val Thr 
865                 870                 875                 880 


Asp Arg His Leu Tyr Lys Met Asp Pro Thr Lys Gln Tyr Lys Val Met 
                885                 890                 895     


Lys Thr Ile Pro Leu Tyr Asn Leu Thr Gly Leu Ser Val Ser Asn Gly 
            900                 905                 910         


Lys Asp Gln Leu Val Val Phe His Thr Lys Asp Asn Lys Asp Leu Ile 
        915                 920                 925             


Val Cys Leu Phe Ser Lys Gln Pro Thr His Glu Ser Arg Ile Gly Glu 
    930                 935                 940                 


Leu Val Gly Val Leu Val Asn His Phe Lys Ser Glu Lys Arg His Leu 
945                 950                 955                 960 


Gln Val Asn Val Thr Asn Pro Val Gln Cys Ser Leu His Gly Lys Lys 
                965                 970                 975     


Cys Thr Val Ser Val Glu Thr Arg Leu Asn Gln Pro Gln Pro Asp Phe 
            980                 985                 990         


Thr Lys Asn Arg Ser Gly Phe Ile  Leu Ser Val Pro Gly  Asn 
        995                 1000                 1005     


<210>  575
<211>  1506
<212>  DNA
<213>  Homosapiens

<400>  575
gcgcttctga caagcccgaa agtcatttcc aatctcaagt ggactttgtt ccaactattg     60

ggggcgtcgc tccccctctt catggtcgcg ggcaaacttc ctcctcggcg cctcttctaa    120

tggagcccca cctgctcggg ctgctcctcg gcctcctgct cggtggcacc agggtcctcg    180

ctggctaccc aatttggtgg tccctggccc tgggccagca gtacacatct ctgggctcac    240

agcccctgct ctgcggctcc atcccaggcc tggtccccaa gcaactgcgc ttctgccgca    300

attacatcga gatcatgccc agcgtggccg agggcgtgaa gctgggcatc caggagtgcc    360

agcaccagtt ccggggccgc cgctggaact gcaccaccat agatgacagc ctggccatct    420

ttgggcccgt cctcgacaaa gccacccgcg agtcggcctt cgttcacgcc atcgcctcgg    480

ccggcgtggc cttcgccgtc acccgctcct gcgccgaggg cacctccacc atttgcggct    540

gtgactcgca tcataagggg ccgcctggcg aaggctggaa gtggggcggc tgcagcgagg    600

acgctgactt cggcgtgtta gtgtccaggg agttcgcgga tgcgcgcgag aacaggccgg    660

acgcgcgctc ggccatgaac aagcacaaca acgaggcggg ccgcacgact atcctggacc    720

acatgcacct caaatgcaag tgccacgggc tgtcgggcag ctgtgaggtg aagacctgct    780

ggtgggcgca gcctgacttc cgtgccatcg gtgacttcct caaggacaag tatgacagcg    840

cctcggagat ggtagtagag aagcaccgtg agtcccgagg ctgggtggag accctccggg    900

ccaagtactc gctcttcaag ccacccacgg agagggacct ggtctactac gagaactccc    960

ccaacttttg tgagcccaac ccagagacgg gttcctttgg cacaagggac cggacttgca   1020

atgtcacctc ccacggcatc gatggctgcg atctgctctg ctgtggccgg ggccacaaca   1080

cgaggacgga gaagcggaag gaaaaatgcc actgcatctt ccactggtgc tgctacgtca   1140

gctgccagga gtgtattcgc atctacgacg tgcacacctg caagtagggc accagggcgc   1200

tgggaagggg tgaagtgtgt ggctgggcgg attcagcgaa gtctcatggg aagcaggacc   1260

tagagccggg cacagccctc agcgtcagac agcaaggaac tgtcaccagc cgcacgcgtg   1320

gtaaatgacc cagacccaac tcgcctgtgg acggggaggc tctccctctc tctcatctta   1380

catttctcac cctactctgg atggtgtgtg gtttttaaag aagggggctt tctttttagt   1440

tctctagggt ctgataggaa cagacctgag gcttatcttt gcacatgtta aagaaaaaaa   1500

aaaaaa                                                              1506


<210>  576
<211>  355
<212>  PRT
<213>  Homosapiens

<400>  576

Met Glu Pro His Leu Leu Gly Leu Leu Leu Gly Leu Leu Leu Gly Gly 
1               5                   10                  15      


Thr Arg Val Leu Ala Gly Tyr Pro Ile Trp Trp Ser Leu Ala Leu Gly 
            20                  25                  30          


Gln Gln Tyr Thr Ser Leu Gly Ser Gln Pro Leu Leu Cys Gly Ser Ile 
        35                  40                  45              


Pro Gly Leu Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Ile Glu 
    50                  55                  60                  


Ile Met Pro Ser Val Ala Glu Gly Val Lys Leu Gly Ile Gln Glu Cys 
65                  70                  75                  80  


Gln His Gln Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Ile Asp Asp 
                85                  90                  95      


Ser Leu Ala Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser 
            100                 105                 110         


Ala Phe Val His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr 
        115                 120                 125             


Arg Ser Cys Ala Glu Gly Thr Ser Thr Ile Cys Gly Cys Asp Ser His 
    130                 135                 140                 


His Lys Gly Pro Pro Gly Glu Gly Trp Lys Trp Gly Gly Cys Ser Glu 
145                 150                 155                 160 


Asp Ala Asp Phe Gly Val Leu Val Ser Arg Glu Phe Ala Asp Ala Arg 
                165                 170                 175     


Glu Asn Arg Pro Asp Ala Arg Ser Ala Met Asn Lys His Asn Asn Glu 
            180                 185                 190         


Ala Gly Arg Thr Thr Ile Leu Asp His Met His Leu Lys Cys Lys Cys 
        195                 200                 205             


His Gly Leu Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ala Gln 
    210                 215                 220                 


Pro Asp Phe Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser 
225                 230                 235                 240 


Ala Ser Glu Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val 
                245                 250                 255     


Glu Thr Leu Arg Ala Lys Tyr Ser Leu Phe Lys Pro Pro Thr Glu Arg 
            260                 265                 270         


Asp Leu Val Tyr Tyr Glu Asn Ser Pro Asn Phe Cys Glu Pro Asn Pro 
        275                 280                 285             


Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Thr Ser 
    290                 295                 300                 


His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn 
305                 310                 315                 320 


Thr Arg Thr Glu Lys Arg Lys Glu Lys Cys His Cys Ile Phe His Trp 
                325                 330                 335     


Cys Cys Tyr Val Ser Cys Gln Glu Cys Ile Arg Ile Tyr Asp Val His 
            340                 345                 350         


Thr Cys Lys 
        355 


<210>  577
<211>  1464
<212>  DNA
<213>  Homosapiens

<400>  577
gcgaggagat gctagagggc gcagcgccgc cagcaccatg cgccccccgc ccgcgctggc     60

cctggccggg ctctgcctgc tggcgctgcc cgccgccgcc gcctcctact tcggcctgac    120

cgggcgggaa gtcctgacgc ccttcccagg attgggcact gcggcagccc cggcacaggg    180

cggggcccac ctgaagcagt gtgacctgct gaagctgtcc cggcggcaga agcagctctg    240

ccggagggag cccggcctgg ctgagaccct gagggatgct gcgcacctcg gcctgcttga    300

gtgccagttt cagttccggc atgagcgctg gaactgtagc ctggagggca ggatgggcct    360

gctcaagaga ggcttcaaag agacagcttt cctgtacgcg gtgtcctctg ccgccctcac    420

ccacaccctg gcccgggcct gcagcgctgg gcgcatggag cgctgcacct gtgatgactc    480

tccggggctg gagagccggc aggcctggca gtggggcgtg tgcggtgaca acctcaagta    540

cagcaccaag tttctgagca acttcctggg gtccaagaga ggaaacaagg acctgcgggc    600

acgggcagac gcccacaata cccacgtggg catcaaggct gtgaagagtg gcctcaggac    660

cacgtgtaag tgccatggcg tatcaggctc ctgtgccgtg cgcacctgct ggaagcagct    720

ctccccgttc cgtgagacgg gccaggtgct gaaactgcgc tatgactcgg ctgtcaaggt    780

gtccagtgcc accaatgagg ccttgggccg cctagagctg tgggcccctg ccaggcaggg    840

cagcctcacc aaaggcctgg ccccaaggtc tggggacctg gtgtacatgg aggactcacc    900

cagcttctgc cggcccagca agtactcacc tggcacagca ggtagggtgt gctcccggga    960

ggccagctgc agcagcctgt gctgcgggcg gggctatgac acccagagcc gcctggtggc   1020

cttctcctgc cactgccagg tgcagtggtg ctgctacgtg gagtgccagc aatgtgtgca   1080

ggaggagctt gtgtacacct gcaagcacta ggcctactgc ccagcaagcc agtctggcac   1140

tgccaggacc tcctgtggca cccttcaagc tgcccagccg gccctctggg cagactgtca   1200

tcacatgcat gcataaaccg gcatgtgtgc caatgcacac gagtgtgcca ctcaccacca   1260

ttccttggcc agccttttgc ctccctcgat actcaacaaa gagaagcaaa gcctcctccc   1320

ttaacccaag catccccaac cttgttgagg acttggagag gagggcagag tgagaaagac   1380

atggagggaa ataagggaga ccaagagcac agcaggactg aaattttgga cgggagagag   1440

gggctattcc atcttgcttc ctgg                                          1464


<210>  578
<211>  357
<212>  PRT
<213>  Homosapiens

<400>  578

Met Arg Pro Pro Pro Ala Leu Ala Leu Ala Gly Leu Cys Leu Leu Ala 
1               5                   10                  15      


Leu Pro Ala Ala Ala Ala Ser Tyr Phe Gly Leu Thr Gly Arg Glu Val 
            20                  25                  30          


Leu Thr Pro Phe Pro Gly Leu Gly Thr Ala Ala Ala Pro Ala Gln Gly 
        35                  40                  45              


Gly Ala His Leu Lys Gln Cys Asp Leu Leu Lys Leu Ser Arg Arg Gln 
    50                  55                  60                  


Lys Gln Leu Cys Arg Arg Glu Pro Gly Leu Ala Glu Thr Leu Arg Asp 
65                  70                  75                  80  


Ala Ala His Leu Gly Leu Leu Glu Cys Gln Phe Gln Phe Arg His Glu 
                85                  90                  95      


Arg Trp Asn Cys Ser Leu Glu Gly Arg Met Gly Leu Leu Lys Arg Gly 
            100                 105                 110         


Phe Lys Glu Thr Ala Phe Leu Tyr Ala Val Ser Ser Ala Ala Leu Thr 
        115                 120                 125             


His Thr Leu Ala Arg Ala Cys Ser Ala Gly Arg Met Glu Arg Cys Thr 
    130                 135                 140                 


Cys Asp Asp Ser Pro Gly Leu Glu Ser Arg Gln Ala Trp Gln Trp Gly 
145                 150                 155                 160 


Val Cys Gly Asp Asn Leu Lys Tyr Ser Thr Lys Phe Leu Ser Asn Phe 
                165                 170                 175     


Leu Gly Ser Lys Arg Gly Asn Lys Asp Leu Arg Ala Arg Ala Asp Ala 
            180                 185                 190         


His Asn Thr His Val Gly Ile Lys Ala Val Lys Ser Gly Leu Arg Thr 
        195                 200                 205             


Thr Cys Lys Cys His Gly Val Ser Gly Ser Cys Ala Val Arg Thr Cys 
    210                 215                 220                 


Trp Lys Gln Leu Ser Pro Phe Arg Glu Thr Gly Gln Val Leu Lys Leu 
225                 230                 235                 240 


Arg Tyr Asp Ser Ala Val Lys Val Ser Ser Ala Thr Asn Glu Ala Leu 
                245                 250                 255     


Gly Arg Leu Glu Leu Trp Ala Pro Ala Arg Gln Gly Ser Leu Thr Lys 
            260                 265                 270         


Gly Leu Ala Pro Arg Ser Gly Asp Leu Val Tyr Met Glu Asp Ser Pro 
        275                 280                 285             


Ser Phe Cys Arg Pro Ser Lys Tyr Ser Pro Gly Thr Ala Gly Arg Val 
    290                 295                 300                 


Cys Ser Arg Glu Ala Ser Cys Ser Ser Leu Cys Cys Gly Arg Gly Tyr 
305                 310                 315                 320 


Asp Thr Gln Ser Arg Leu Val Ala Phe Ser Cys His Cys Gln Val Gln 
                325                 330                 335     


Trp Cys Cys Tyr Val Glu Cys Gln Gln Cys Val Gln Glu Glu Leu Val 
            340                 345                 350         


Tyr Thr Cys Lys His 
        355         


<210>  579
<211>  2220
<212>  DNA
<213>  Homosapiens

<400>  579
aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg     60

cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca    120

gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga    180

aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag    240

caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga    300

tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca    360

gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac    420

caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg    480

catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact    540

gaccttgaag gtggggtccc tgctggggga cagagagaag gcctcttgtt ttagcctcat    600

ccaacagttt agtaactgtg tttatatttt gattacgtgt cctcaaattg tgatattttg    660

atgacaagac agagcccttg agtttgggat cctttctgtt ggagttgagt tattgtgagc    720

ctgaaagtac ccagttcctt tgccagtgct tgaaacaaac catgaagtgg cctctcttag    780

gatccaggtc ttttcccatt tactgaactt atcatgaaag tgagtgctac tacgaggggt    840

ccaatcacag gctgagaaat tgtgttacag aatctactct tggaagaatg aagacgtggc    900

tgtcctttgg tacctcgctt taaggtggct ttcccttagg acccctactg tggactgcct    960

tataactaaa accttttgta ttttagtaac tgaatcccca ctgtgcagtg ttagggctgc   1020

ctggttgttt gcagtagatt agagctttag aagcttctag agcttctaaa gcccgtgctg   1080

gtgatcccag cgactcttca ctccctagcc ttaggtattc ctagaagccc tgaccagttg   1140

gcactgctga gactccagcc cctgggagtg gtttacagaa acattacaca gactctgatg   1200

tcagtcatga tgtttcagcc tctgcccttt tcctgtatca accctgatgg ataatagggc   1260

gtgggttctg tctgttatca gggtgtggtc ccctgtgaat gaagcactcc cagccactga   1320

gctgtgagaa acagtcactc ggaagtgtga gctttatctt agtttttgtt ggatcatgtt   1380

gagtctgtca gctccacagg acttcagtac gtttctgaac agtccctgcc atctctacgg   1440

gggagagggt caggcaagct gcaagtgaca ctcacctcct gctgacagtt gcagtgtctc   1500

agatggcctg gaagggtggt ctccagcagc ctgctgggcg ctcccctttc atgagagcca   1560

cctgcagtga cctgaactga tacatgttga ttagtctgcc ctttctttag aaaactgcta   1620

ctctcctttt catatctcag aaaaacagta gaggcctttt aggaccaaac tccatgtcac   1680

actgatgaag agccagtggg ggttagagcg tcctgttaag gcacatgcta acttcccact   1740

caagtctggc agcgctgggg catcagcaca cctcttgcca cccacactga taccagaggg   1800

gaaggctgtg aggtggctgg gggttgagac ttgaggtttc taactttcct ctgcacacct   1860

gtggctacct ggtgtttgtc tcttgattcc ctccacctgc ctcacaccct gcctccgtcg   1920

ggattttcca cctacaccat tcaaaaggaa cataggagag ggcatgaagg ggctaggctg   1980

aagcactctg atgactgggg ccaatttgtg gctgaaaatg aatacatttt ttgaaattta   2040

tggtcatttt caagtgattt agaaggttga tccttagcct catacagtga tgaaataatc   2100

tgtgtgttca gagccaagca ggactttagc aagagtctga ttgtattgtc actatctcgg   2160

ggaaaaaaaa atacaaatac atttctctga tctctgatgg caatgaagtt tgacttgtaa   2220


<210>  580
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  580

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Val 
145                 150                 155                 160 


Gly Ser Leu Leu Gly Asp Arg Glu Lys Ala Ser Cys Phe Ser Leu Ile 
                165                 170                 175     


Gln Gln Phe Ser Asn Cys Val Tyr Ile Leu Ile Thr Cys Pro Gln Ile 
            180                 185                 190         


Val Ile Phe 
        195 


<210>  581
<211>  3319
<212>  DNA
<213>  Homosapiens

<400>  581
aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg     60

cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca    120

gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga    180

aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag    240

caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga    300

tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca    360

gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac    420

caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg    480

catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact    540

gaccttgaag gggactcaga agaagatcct tgacattgcc aacatgctgg gcttgtccaa    600

cacagtgatg cggctcatcg agaagcgggc tttccaggac aagtacttta tgataggtgg    660

gatgctgctg acctgtgtgg tcatgttcct cgtggtgcag tacctgacat gagccagcca    720

cgctcagtgg ctgaacagca ttcccacagc ctgcaagtgt gtgtgtgtgt gaaagagaga    780

ggggggccca gaggccgcct tttgaaatgt ttgcctgtct gaactgtgaa gacacttggg    840

agtgattgtg gtctaatttc caacctgctc tgttttctgt gacatcttgg agggggagct    900

agtgccacca ccatgcgcgg tgcttaggaa atgaaagaag tcccgggtct gtctctctca    960

ctctcgctct cactggggga gggaaagaat ggctttggtg gctttgttca catagctgat   1020

gcgtgccctg ggaaggtgtc cacagtgagc cctgtgtgca ggactgtcca cacggttcac   1080

accttgtcac catcaggcct ttctggctcc tgatagggtg gagcaaaagt ggaaaggaaa   1140

ggaaagaggc cttttctcac agccattata ttaaatagta ggtcgattca catcctcgtg   1200

ctcctggcca ccctcccctg tgcctcagtg acatgtagat gactgactgc caatacttgt   1260

caccattccc tggaagcagc tacctagggg aaacaagatg tagtgctatt gccgataaca   1320

agtaagattt tccacactac agctgggtgt ttctcttttc taaagtgagg ccagtgttat   1380

ttcccgggag tgttcagtct tgaccctagt cactgatttt ttctagttgt taatagagtg   1440

gttggctttt aaggttcaga gactgtggct tggcacctgc gcccaggctt tgtgggcctt   1500

tgccccttag aaagtagctg taggcaaaga tttgtgattt tccaattaca gtctcagctc   1560

tagttttagt atctctaatt ctttggttcc cttctcttcc ctgaaatata ttagcacctg   1620

ccagccaggc cctcattttg cccagccagt gtgggcagat cccaccgtgg agacatctgt   1680

agtgtgtatg tccttgtaac actctgtttt cagggactac aacctttttc cttctgtgac   1740

cagccccgga ttcaggctgt actaatacca ggtatattgt ggaatttagt ataaaggcca   1800

atctgtcctg aagtccatct aatgtggtga atcactgaaa gtctcagaaa gacctggtta   1860

gtgtatgttc tcatttacca caggcctacc agccctgggc acagcagctt catggcaaga   1920

cataaaatga cactcaaaat ccttcagatc tggaaaccgg ctcagtatta accctacctt   1980

tggttgtcct gccctacctg ctctgttagt ttcttgttgc ttgaactgtc ttctgtctta   2040

tttcccttcc tttctgtgtt cctcttcacc tctcttgttc ccctccccgc tgctctgtag   2100

tcatgttggt cctttcaggc acctctgtgg catagctccc ctttggtaag ttttcttaat   2160

tgtcatagat taactgagtt tcctggatgc taatttcaca ctttcggttg gaggagatct   2220

ccattgttcc tacccctccg ggccaaatgg gccccaggtt tccaaggaag gagcaatctg   2280

tgactcctaa aatgggttgg ggccctgcca gagttaaagc agtgactgga gggtggactg   2340

gggggttgca gcatctttag acctagatct gtctaactct ggggaggcac attgacattt   2400

ccattacaca cagcactgct gcggtgccag ggacctagcg caggactttt ggtaatccat   2460

aaaatggatt ctgagactgc gacggcaagg ctgtcctgtc ccccaggcac ccaaggatcc   2520

tgccagacag cacactttgg aggaaggtct gcagggagca gctgagccat ttgttcttga   2580

actctgggag gcagaagtcc ccgcacccat catgcgtgga ctgataggac atcttttcgt   2640

ggtgtgcacc agtgctttcc acacttgaca gtggttggct ttgatgaacc ctcatgctgc   2700

accttcagag ccagtcctct agtttggaat aaaaattgca gaggtggttt ttgggtcttt   2760

accacctgcg gctggtggac agcagccagt gtgtctggac acccaggggc attgagactg   2820

catgttgtca catgaccact tctcttcaca catctgcttt cagtgcctgg tgaaaaatag   2880

accttggcct aacagtgtga ctctctccac cgcctcagtg tagggaaggg tccaggccag   2940

ggaaggagca ccctctagtg gaggcggggg tgaattctta ggtcgagctg atgcaagaaa   3000

ctccggtagc cagcctctgt gaccttgtac atgagtttgg tgtgcctatt gtgatttaaa   3060

acaggtgggt tatcaagagg aacttgagat ctctttatta catggacatt tacttcaggg   3120

ggaccactgt aagaaaagcc aaactccaag accaagtaag ttagaggagt cttgattttt   3180

tagacttcac tgcggagttc tgtacaccct ttgccctgat gaatttgaat gggtttgatt   3240

tgcaaatttg gatttacacc cattgttttg gaagcacatc agctgaataa agttgaggtt   3300

tattttattt agaaaatca                                                3319


<210>  582
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  582

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly 
145                 150                 155                 160 


Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn 
                165                 170                 175     


Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe 
            180                 185                 190         


Met Ile Gly Gly Met Leu Leu Thr Cys Val Val Met Phe Leu Val Val 
        195                 200                 205             


Gln Tyr Leu Thr 
    210         


<210>  583
<211>  1469
<212>  DNA
<213>  Homosapiens

<400>  583
aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg     60

cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca    120

gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga    180

aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag    240

caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga    300

tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca    360

gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac    420

caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg    480

catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact    540

gaccttgaag gggactcaga agaagatcct tgacattgcc aacatgctgg gcttgtccaa    600

cacagtgatg cggctcatcg agaagcgggc tttccaggac aagtacttta tgataggcac    660

ccaaggatcc tgccagacag cacactttgg aggaaggtct gcagggagca gctgagccat    720

ttgttcttga actctgggag gcagaagtcc ccgcacccat catgcgtgga ctgataggac    780

atcttttcgt ggtgtgcacc agtgctttcc acacttgaca gtggttggct ttgatgaacc    840

ctcatgctgc accttcagag ccagtcctct agtttggaat aaaaattgca gaggtggttt    900

ttgggtcttt accacctgcg gctggtggac agcagccagt gtgtctggac acccaggggc    960

attgagactg catgttgtca catgaccact tctcttcaca catctgcttt cagtgcctgg   1020

tgaaaaatag accttggcct aacagtgtga ctctctccac cgcctcagtg tagggaaggg   1080

tccaggccag ggaaggagca ccctctagtg gaggcggggg tgaattctta ggtcgagctg   1140

atgcaagaaa ctccggtagc cagcctctgt gaccttgtac atgagtttgg tgtgcctatt   1200

gtgatttaaa acaggtgggt tatcaagagg aacttgagat ctctttatta catggacatt   1260

tacttcaggg ggaccactgt aagaaaagcc aaactccaag accaagtaag ttagaggagt   1320

cttgattttt tagacttcac tgcggagttc tgtacaccct ttgccctgat gaatttgaat   1380

gggtttgatt tgcaaatttg gatttacacc cattgttttg gaagcacatc agctgaataa   1440

agttgaggtt tattttattt agaaaatca                                     1469


<210>  584
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  584

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly 
145                 150                 155                 160 


Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn 
                165                 170                 175     


Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe 
            180                 185                 190         


Met Ile Gly Thr Gln Gly Ser Cys Gln Thr Ala His Phe Gly Gly Arg 
        195                 200                 205             


Ser Ala Gly Ser Ser 
    210             


<210>  585
<211>  1134
<212>  DNA
<213>  Homosapiens

<400>  585
agcggaggtt ctccggctcc agctcctgcg ccgcctgttg ctcgctcctc cgggcggtcg     60

cttcccgccc ggtgcccagg ggtaggcggc ccgagagcgc gcaggcagcc agcctcccgc    120

cttcgtcccc tccccgtacc gcaggagccg gtccgagggg tccggagcgt ccctgagagc    180

gcggaccccg gcgagcagcc cagtgcaccc gggactgcgc gccgagaccc ccggcgccgc    240

gcggcgatga acgcgacctt cctgaaccac agcggcttgg aggaggtgga cggcgtgggc    300

ggcggcgccg gggccgccct gggaaaccgc acccacgggc tgggcacgtg gctgggctgc    360

tgtccagggg gcgcaccgct ggccgccagc gacggggtcc ccgcggggct ggcgcccgac    420

gagcgcagcc tgtgggtgtc gcgggtggcg cagatcgccg tgctctgcgt gctgtcgctt    480

accgtggtct tcggcgtctt cttcctgggc tgcaacctgc tcatcaagtc cgagagcatg    540

atcaactttc tggtgcagga gcgccggccc tccaaggacg tgggcgcagc catcctgggg    600

ctgtactgag cgccatctgg gtccgccctc gccagcgctg ctgcaagaag gaccccggag    660

acccggaccc tcgccccgct ctctgcgctc tgccgccgcc tccgggcggg cagctacgtg    720

cctggggcgc ccgggcgggg acgcggcgag actgtcggcg ggggcgcggg aagggacttg    780

gacgcccggc tctgtcctgt gtgcgctgca gcgttgcggg gtgggagaat gtggggtgag    840

ggttcttacc agtttttttt ttgtttgttt gttttttaag acgttcgggg cagggtggga    900

gtgggtatgg agatgcaatt tgggactgcg gtcgctcgcg tgggagtttt gtgtgtacgt    960

tggtgcgggt gggttcggaa cacggtgcga gtgggtgaag atgtgaagcg tcagagtcgc   1020

tgagcttgtt ggcctgatct tgcgtttgga aagaaatctt gtaataaaac tgcagccgta   1080

gggcttcagg cagcttccca aaaaaaaaaa aaaaaaacaa aaaaaaaaaa aaaa         1134


<210>  586
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  586

Met Asn Ala Thr Phe Leu Asn His Ser Gly Leu Glu Glu Val Asp Gly 
1               5                   10                  15      


Val Gly Gly Gly Ala Gly Ala Ala Leu Gly Asn Arg Thr His Gly Leu 
            20                  25                  30          


Gly Thr Trp Leu Gly Cys Cys Pro Gly Gly Ala Pro Leu Ala Ala Ser 
        35                  40                  45              


Asp Gly Val Pro Ala Gly Leu Ala Pro Asp Glu Arg Ser Leu Trp Val 
    50                  55                  60                  


Ser Arg Val Ala Gln Ile Ala Val Leu Cys Val Leu Ser Leu Thr Val 
65                  70                  75                  80  


Val Phe Gly Val Phe Phe Leu Gly Cys Asn Leu Leu Ile Lys Ser Glu 
                85                  90                  95      


Ser Met Ile Asn Phe Leu Val Gln Glu Arg Arg Pro Ser Lys Asp Val 
            100                 105                 110         


Gly Ala Ala Ile Leu Gly Leu Tyr 
        115                 120 


<210>  587
<211>  4767
<212>  DNA
<213>  Homosapiens

<400>  587
gcccccgtag ttagcgcggt gcttctcttc cgctccgggt cggctccgtt tccctttccg     60

ggcgggcagg cggcggaccc cagtgtcttt atccctcttt tgcacagtca gcttctgcag    120

ctctcccggg ctagcatggc agcgtggaag agttggacgg ccctgcggct ctgcgccaca    180

gttgttgtac ttgatatggt cgtctgtaaa ggatttgtag aagatttaga tgaatcgttt    240

aaagaaaatc gaaatgatga catttggctt gtagattttt atgcgccatg gtgtggccat    300

tgtaaaaagc tggaaccaat ttggaatgaa gttggtcttg agatgaaaag cattggttct    360

ccagttaagg ttggaaagat ggatgctact tcctattcta gcattgcttc agagtttgga    420

gttcgaggtt atccaacaat taagctatta aaaggggact tggcatataa ttatagagga    480

ccacgaacaa aagatgatat tattgagttt gctcacagag tatctggggc tctaattcgg    540

ccacttccaa gtcaacaaat gtttgaacat atgcagaaga gacaccgtgt atttttcgtt    600

tatgtaggtg gagaatcacc tttgaaagag aaatacatag atgctgcttc agaattgatt    660

gtatatacat acttcttttc tgcctcagaa gaagtggttc ctgagtatgt gacactaaaa    720

gagatgccag ctgtgcttgt tttcaaagat gaaacttact ttgtttatga tgagtatgaa    780

gatggtgatc tgtcatcatg gatcaacagg gaaaggtttc agaattacct tgctatggat    840

ggcttcctct tgtatgaact tggagacaca ggaaagcttg tggctcttgc agttattgat    900

gagaaaaata catcagttga acataccaga ttgaagtcaa ttattcagga agttgcaaga    960

gattacagag acctcttcca tagggatttt cagtttggcc acatggatgg aaatgactac   1020

ataaatacct tgctgatgga tgaattgaca gtcccaactg tagttgtact gaatacttca   1080

aaccagcaat atttcttgct agatagacag attaagaatg ttgaagacat ggtccagttt   1140

attaataaca ttttggatgg cacagtagaa gcccaaggag gtgatagcat tttgcagaga   1200

ttgaaaagaa tagtatttga tgccaaatct actattgtgt ctatattcaa gagctcacca   1260

ctgatgggct gctttctctt tggcctgcca ctgggtgtca tcagtatcat gtgctatgga   1320

atctacacag ccgacacaga tggaggttat atagaagaac gatatgaagt gtctaaaagt   1380

gaaaatgaaa accaagaaca gatagaagag agcaaagaac agcaggagcc cagcagtgga   1440

ggatctgtag tgcctacagt gcaggagccc aaggatgtat tagaaaagaa gaaagattga   1500

gacttgatga ctataaaata tttgttagga cttcaaatta ttaaagagtc tatttattga   1560

atttagacat ttaatcatga tctttacaga aaagaacatg ttattcgtat tttgctaata   1620

tcaactgcat ggattaaagt agtccctcca tacatgggga agtgtttgga gcaaagagat   1680

gaacagtttg tctgaaacaa acacagagca ctccatcaaa atttacctga tctttgtgat   1740

tagaacagaa caattctatt tgcatgtttc tctatctgaa tattctgtga caaaaagtta   1800

agattcttgg gcagaatatt taaattggtc agtcaggtag aagatacatg tgtgatatag   1860

aaaaataatg cctctcctgc tgccatccgt ttccctcata tattttggac aagatttata   1920

tggacaaaat taagtcttta aaatttaggc actttaagga gaactaataa ctttttccat   1980

gtatcaagat tatgaggtta aaaataatgt ggttttatat agcatagtgg ttttattttg   2040

ttagttattt ttaaaggaga agaaatgtta ctttttaact ttatactcag ttgcattatc   2100

ataaaatttt catatatgcc tagataatgg ggaaaaaaag tcttgtgatt gactttcgca   2160

aaataaacag gatttactga gtagaggttt cagcccattc cttggaatac taacaggtat   2220

ttcatcagtc attgtaggtt gggaagggtc tctgttaatc ctactctgct ttagccagaa   2280

tagcctagta ttttatttct attttatata ttgagatttc ttctaacatt tcctttgata   2340

aaaatcttct gctttttgaa aagtggtatg tatcatattt ttatgtttct ggtgtgtgaa   2400

ctttatggta acttctactc tagaatacgt acgtatgcac ccacagacac acacagttta   2460

ttgacacatc tattatgtaa tgctgtagac ctgtccgtgt ctgcttcata aggagtaacg   2520

actgacatta gcatgtccag tgacaagtca catccggtgt aaaaaaaaga gatcagccag   2580

ttaccttctc cattgtctta gttctgtcac ccatttcgtc aagtgacctc tcatcttcta   2640

taaactaata caggaattct ttccaaagca atgtctaaaa actctttttt ttaaagtaac   2700

agtttggtat gtttattgta gataaattat ttttgaggcc ttcattttag ctaagtttag   2760

aatttatatt aggcaactat gatttgagtg gttattcatt gagtaatttt ccactataaa   2820

gaattttatt gaacatttat taaaaaataa tgtaatgcat ggtcaaaaaa tatgtaattc   2880

atggtctgga cactgacgtt gtttagggat ttagtcatca aggacagccc tctgttgttt   2940

ctaatgccgt actaatcaag actgtatgga cacttgcatc ttaagtacta aggaattact   3000

agtgattgtt ttattttatc catgtactct tttagtattt aataattaaa tacctattct   3060

tagtgtttga cactccatat ttcttttttt tggaaatgaa acaaatatgc agtccaaaat   3120

tcaggaacta ctagagtgaa atgatattaa gtggaaacca gagataaatg ctgttaattt   3180

aacaagtaga ttcttctcca aagaatgatg agtgattctt gggaagataa atgttaatgt   3240

tcccaatagt caagcttgtt ttgcagtagt gaaaagctta gatgagtacg gatacctcat   3300

ttgaaactca gcctagtaag gaagtgaaaa cttagcagtc agtgacatgg ggaaatagtt   3360

atagaaaatg tcactgaatt ttttcatatt tataattagt catttacata tttttgtctt   3420

gttgatcatt acctgtaaat gaaagacctt aataggaaaa aaagagtaaa gctcagtgtg   3480

aatgcaaaca tccacaaaat atgatcttcg tttatattct gtgatgttgt ttataaatga   3540

atgcctcagt tctctgctac ccttttcaca gctttgtact gtttgcctta tattctattt   3600

gtgcttttaa agtgtgtctg ttgggaaaac aaaatgtgta ggtggtttgt aagtgaataa   3660

tttttatttc ttcttgtatt aaaattttgt ttttttctct actttgggag atgtttattt   3720

acattgtcag actattcaca aaacagattc taaaatttgt ttgctcgtat gctgttccct   3780

tcaatgtgat atcagagatt actatgaatg ttagtttcat tccgtgaaac attacttcca   3840

tataaagaca gatctcttaa taagtgaatc tagtggaaga acataggtat cattctaatt   3900

ccatggtaaa ttttgtcatg attctatatg aataatgggg tccttcagga agttggaatt   3960

tttgccttct cttttaattg cagtgaagtt ctctttataa cttctaaaat tcggaattct   4020

agatccttgc ttttgcagaa tttggtgctc agacaatatt taaggacatt tcagcgagac   4080

aaagtgcatg tttttatcga gtaccctgtg caccacatta tatctggcaa ttctttttgt   4140

ttcattatgt gcatcaatat ttttctcagc tactattacc tgaaacttgt ttaacatgta   4200

ttagacctag aattttcatt ttctttctca catagttgct tcctggtatc tgatttagaa   4260

ataacattta aatgccaagt atctggggga ttgaaggaag ggtctatatg agcaggtgaa   4320

ttagcagtac tgtttttgtt tagtggatat tgttagtgac tttttgtgtg tgttttgctt   4380

tgggaccttt ttattttggt gttgcaaaaa gtaacatatt ttcatcattg cttcatacga   4440

catggagtta ggacagggaa aaatcattca acactcctta tgcattaaat gatcaaataa   4500

accagtgtag gatattaaga ctatcaattg gtgggattag gcttgacatt ttatttttat   4560

aaatatatat tttttctgaa tgtgtctgag tccaagagtg ggcaaaaaat aattttctac   4620

tttggactaa tctatagagg tttttgaaag tctgcattac taacttgttg aattcatgat   4680

attctgccta tggcacaaat tgtaaacctt tgtttttcta aaataaagta attgaaaacc   4740

tgcaaaaaaa aaaaaaaaaa aaaaaaa                                       4767


<210>  588
<211>  454
<212>  PRT
<213>  Homosapiens

<400>  588

Met Ala Ala Trp Lys Ser Trp Thr Ala Leu Arg Leu Cys Ala Thr Val 
1               5                   10                  15      


Val Val Leu Asp Met Val Val Cys Lys Gly Phe Val Glu Asp Leu Asp 
            20                  25                  30          


Glu Ser Phe Lys Glu Asn Arg Asn Asp Asp Ile Trp Leu Val Asp Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Lys Leu Glu Pro Ile Trp Asn 
    50                  55                  60                  


Glu Val Gly Leu Glu Met Lys Ser Ile Gly Ser Pro Val Lys Val Gly 
65                  70                  75                  80  


Lys Met Asp Ala Thr Ser Tyr Ser Ser Ile Ala Ser Glu Phe Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Leu Leu Lys Gly Asp Leu Ala Tyr Asn 
            100                 105                 110         


Tyr Arg Gly Pro Arg Thr Lys Asp Asp Ile Ile Glu Phe Ala His Arg 
        115                 120                 125             


Val Ser Gly Ala Leu Ile Arg Pro Leu Pro Ser Gln Gln Met Phe Glu 
    130                 135                 140                 


His Met Gln Lys Arg His Arg Val Phe Phe Val Tyr Val Gly Gly Glu 
145                 150                 155                 160 


Ser Pro Leu Lys Glu Lys Tyr Ile Asp Ala Ala Ser Glu Leu Ile Val 
                165                 170                 175     


Tyr Thr Tyr Phe Phe Ser Ala Ser Glu Glu Val Val Pro Glu Tyr Val 
            180                 185                 190         


Thr Leu Lys Glu Met Pro Ala Val Leu Val Phe Lys Asp Glu Thr Tyr 
        195                 200                 205             


Phe Val Tyr Asp Glu Tyr Glu Asp Gly Asp Leu Ser Ser Trp Ile Asn 
    210                 215                 220                 


Arg Glu Arg Phe Gln Asn Tyr Leu Ala Met Asp Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


Glu Leu Gly Asp Thr Gly Lys Leu Val Ala Leu Ala Val Ile Asp Glu 
                245                 250                 255     


Lys Asn Thr Ser Val Glu His Thr Arg Leu Lys Ser Ile Ile Gln Glu 
            260                 265                 270         


Val Ala Arg Asp Tyr Arg Asp Leu Phe His Arg Asp Phe Gln Phe Gly 
        275                 280                 285             


His Met Asp Gly Asn Asp Tyr Ile Asn Thr Leu Leu Met Asp Glu Leu 
    290                 295                 300                 


Thr Val Pro Thr Val Val Val Leu Asn Thr Ser Asn Gln Gln Tyr Phe 
305                 310                 315                 320 


Leu Leu Asp Arg Gln Ile Lys Asn Val Glu Asp Met Val Gln Phe Ile 
                325                 330                 335     


Asn Asn Ile Leu Asp Gly Thr Val Glu Ala Gln Gly Gly Asp Ser Ile 
            340                 345                 350         


Leu Gln Arg Leu Lys Arg Ile Val Phe Asp Ala Lys Ser Thr Ile Val 
        355                 360                 365             


Ser Ile Phe Lys Ser Ser Pro Leu Met Gly Cys Phe Leu Phe Gly Leu 
    370                 375                 380                 


Pro Leu Gly Val Ile Ser Ile Met Cys Tyr Gly Ile Tyr Thr Ala Asp 
385                 390                 395                 400 


Thr Asp Gly Gly Tyr Ile Glu Glu Arg Tyr Glu Val Ser Lys Ser Glu 
                405                 410                 415     


Asn Glu Asn Gln Glu Gln Ile Glu Glu Ser Lys Glu Gln Gln Glu Pro 
            420                 425                 430         


Ser Ser Gly Gly Ser Val Val Pro Thr Val Gln Glu Pro Lys Asp Val 
        435                 440                 445             


Leu Glu Lys Lys Lys Asp 
    450                 


<210>  589
<211>  2015
<212>  DNA
<213>  Homosapiens

<400>  589
acaaataata aggaacaagg tgtggttatt gattctctaa aattaagtga ggagatgaag     60

cccaatctag atggtgttga tttattcaac aatggtggtt ctggaaacgg tgaaacgaaa    120

actgggctga gactgaaagc aataaatctg cctttggaaa atgaagtaac tgaaatttca    180

gctttgcagg tgcatttgga tgaattccaa aaaatcttat ggaaggaaag agaaatgcgc    240

acagctttgg aaaaagaaat agagagactg gagtcggctt tgtctctgtg gaagtggaag    300

tatgaagaac tgaaagaatc aaagccaaaa aatgtgaaag agtttgacat tcttcttggt    360

caacataatg atgaaatgca agaactgtca ggcaatataa aggaagaatc caaatctcaa    420

aacagcaaag acagagtgat ttgtgagtta agagcagagc tagagagatt gcaagctgaa    480

aatacctcgg agtgggacaa gagggaaata cttgaaagag aaaagcaggg actggagaga    540

gaaaatagaa ggctgaagat ccaggtgaaa gaaatggaag agcttttgga taagaaaaat    600

agattaagtg caaactctca aagtcctgat ttcaagatgt cacaaattga tctgcaagaa    660

aaaaaccagg aattactgaa ccttcaacat gcctactata aactaaacag acaataccag    720

gcaaatattg cagaactgac tcatgcaaac aaccgagtgg atcaaaatga agcagaagta    780

aagaaactaa gattacgagt ggaagaacta aagcagggac tcaaccaaaa agaagatgag    840

cttgatgatt ccctgaatca gatccgtaag ctccagaggt ctctggatga agagaaagaa    900

agaaatgaaa acttagagac tgaactcagg cacttgcaaa actggtaatt ttttcacaaa    960

atatgctgaa ttaaagatta gggccttaaa gacatttcca tatccttttc ttaaatatca   1020

gtaaaattgt ttttattaac tagaaatatt aatgaaaaaa acgtagacaa tacacaaatt   1080

aatgggcttc ttcacttctt ctaatttttg cctaacagat actgcatatt ctcaaaaaga   1140

caatttaaat gtcatttaaa aacaacttta attctaagat gtgtaaatat tttgaaagtc   1200

aaaaagggct ttcagaatac tttttacata aaatctgaaa gagttataat atcggtaaga   1260

aaaagtaagt tgaaaaccat acaagacgct gggtcattaa taagaaaacc attgacttta   1320

agtataaagt actggtttgt ttaaataatt ggtaaacttt tatgtacgtg ttgtctatgt   1380

ggtggggatg gcaggttgta ttaacaaaaa tgaatcattc tagaggtgta acaatacatt   1440

tcttatataa ttttataagt catttctaat ctttgtataa aacagaagtg agcaagatga   1500

atcagaaaaa aggtgttttg tattttaaag gtaacagata accaggtgat tgaatctaag   1560

acaggctgta agcatcgctg agaaactaaa aggacttttg acttttatct ggatagacat   1620

ttctacagta aaatcatgga aaggcatcag cattgcaaag tagcatctag gtagaaatca   1680

ggccaaaatt aagctgtggt ttccctctga gtagtgggaa tagagaaaat taggaaattg   1740

tggttatgtg aatatttctt taaaactttt atgtacatta tagtttattg cttcatattt   1800

aagtttagtt tttaaggtaa aatgttattt tgaacaaaaa gacacttata attttccata   1860

cctattttca actgaaggca acttgtaaga tttaactcag tcaataacat actggtttta   1920

ctcatctccc cctccattga ttagccaaaa aaaaatgaaa tcttactaat tcattattga   1980

ataaagacca cttttatcag agtcaaaaaa aaaaa                              2015


<210>  590
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  590

Met Lys Pro Asn Leu Asp Gly Val Asp Leu Phe Asn Asn Gly Gly Ser 
1               5                   10                  15      


Gly Asn Gly Glu Thr Lys Thr Gly Leu Arg Leu Lys Ala Ile Asn Leu 
            20                  25                  30          


Pro Leu Glu Asn Glu Val Thr Glu Ile Ser Ala Leu Gln Val His Leu 
        35                  40                  45              


Asp Glu Phe Gln Lys Ile Leu Trp Lys Glu Arg Glu Met Arg Thr Ala 
    50                  55                  60                  


Leu Glu Lys Glu Ile Glu Arg Leu Glu Ser Ala Leu Ser Leu Trp Lys 
65                  70                  75                  80  


Trp Lys Tyr Glu Glu Leu Lys Glu Ser Lys Pro Lys Asn Val Lys Glu 
                85                  90                  95      


Phe Asp Ile Leu Leu Gly Gln His Asn Asp Glu Met Gln Glu Leu Ser 
            100                 105                 110         


Gly Asn Ile Lys Glu Glu Ser Lys Ser Gln Asn Ser Lys Asp Arg Val 
        115                 120                 125             


Ile Cys Glu Leu Arg Ala Glu Leu Glu Arg Leu Gln Ala Glu Asn Thr 
    130                 135                 140                 


Ser Glu Trp Asp Lys Arg Glu Ile Leu Glu Arg Glu Lys Gln Gly Leu 
145                 150                 155                 160 


Glu Arg Glu Asn Arg Arg Leu Lys Ile Gln Val Lys Glu Met Glu Glu 
                165                 170                 175     


Leu Leu Asp Lys Lys Asn Arg Leu Ser Ala Asn Ser Gln Ser Pro Asp 
            180                 185                 190         


Phe Lys Met Ser Gln Ile Asp Leu Gln Glu Lys Asn Gln Glu Leu Leu 
        195                 200                 205             


Asn Leu Gln His Ala Tyr Tyr Lys Leu Asn Arg Gln Tyr Gln Ala Asn 
    210                 215                 220                 


Ile Ala Glu Leu Thr His Ala Asn Asn Arg Val Asp Gln Asn Glu Ala 
225                 230                 235                 240 


Glu Val Lys Lys Leu Arg Leu Arg Val Glu Glu Leu Lys Gln Gly Leu 
                245                 250                 255     


Asn Gln Lys Glu Asp Glu Leu Asp Asp Ser Leu Asn Gln Ile Arg Lys 
            260                 265                 270         


Leu Gln Arg Ser Leu Asp Glu Glu Lys Glu Arg Asn Glu Asn Leu Glu 
        275                 280                 285             


Thr Glu Leu Arg His Leu Gln Asn Trp 
    290                 295         


<210>  591
<211>  1965
<212>  DNA
<213>  Homosapiens

<400>  591
agcgggttcc ccgtccgcgg cggccctgca ggcgaccccg cgtccccacc ggcgggagct     60

cggggaagag cgggcggcgg cgctgctgct ggcggcggcc ggctggatgc gagacccgcg    120

cagacccggc ggcggacggc ggctctcgac tccggagagc ggatcgcggg gcgcaggagc    180

ccgatcgcgc tggccatggc ctccaacttt aacgacatag tcaagcaggg ctacgtgaaa    240

atccgcagca ggaagcttgg gattttcaga cgatgctggt tggttttcaa gaaggcttct    300

agcaaaggac ccagaaggtt agaaaaattt ccagatgaaa aggcagctta tttcagaaac    360

tttcataagg taactgaact gcacaatatc aaaaatataa ccagactgcc ccgagagaca    420

aagaagcatg cggtggcaat catctttcac gatgaaacat cgaagacatt tgcctgtgag    480

tcagagctgg aggccgagga gtggtgcaag cacctctgca tggagtgtct ggggacaagg    540

ctcaatgaca tcagccttgg ggagcccgac cttctggccg caggagtgca gcgggaacag    600

aatgagagat tcaacgtgta tcttatgcct acgccaaacc tggatattta tggtgaatgc    660

acaatgcaga tcactcatga aaatatctat ctctgggata tccacaatgc caaggtcaaa    720

ctggtgatgt ggcctctcag ctcactgagg agatacggtc gggactcaac gtggtttacg    780

tttgagtcag gaagaatgtg tgacacagga gaaggactat tcacttttca aacaagggaa    840

ggagaaatga tctatcagaa ggttcattct gcgacactgg ccatagctga gcaacatgaa    900

agattaatgc tagaaatgga acagaaggcc cggcttcaga caagcttgac tgaaccaatg    960

acattatcca aatcaatatc tcttcctcgc agcgcgtact ggcatcacat cactcgtcag   1020

aacagcgttg gtgaaatcta cagtttgcaa ggtcatgggt ttggttcgtc aaagatgtct   1080

cgtgcacaga catttcccag ctacgcccca gaacagagtg aagaggccca gcagccgttg   1140

tcgcggtcca gcagctatgg attcagctac agctccagcc tcatccaatg acacacagag   1200

agccgctgtt gactagagag acagtctgtc ctggacccgt ctgtggggtc attaccctct   1260

gcctcctgga agaccaattg cagtacaaat tgaaatgggt cggctctagc cccagtccca   1320

ttggaaggtt aaaaactgga gttctgcttc cttgattcag tggctaagtc ctttatttat   1380

tgaatttctt tgggggaatc tatgttttac ataaatagaa tccaaatcgt atgaacagtt   1440

atttaaataa acaaaattct ttgggtctga cagtaacaga aacctcagca ctgggaaaag   1500

ctgcccacac tggggtatgc ctgggtgatg ggcacctctc actgacctca cagcgcagtc   1560

cgcccatctg agcacagggt ctgtccttag acataatggt gaccctccac aagctctgtg   1620

gcttttaaag ttctgacagg gataaataca gtaagctctg caaatgacat cgtagctgca   1680

tataaataaa cccagtgaca attaaaggaa catgaaattc agaacacact attaagcagg   1740

gccctgtagc tctactcgtg tgtgtgtgtg cgtgtgtgtg tgtgtgtgta gacaaatgga   1800

tattgctata tccatctata tataacaagt atatatcaaa catgtgctgg gggtgacagg   1860

atatgctcac ttaaattgtt gaaaaccata atttggtgca ttaaagttaa gattgttatg   1920

ttgaatagct atttttaaaa tagtgctgta aaaaaaaaaa aaaaa                   1965


<210>  592
<211>  331
<212>  PRT
<213>  Homosapiens

<400>  592

Met Ala Ser Asn Phe Asn Asp Ile Val Lys Gln Gly Tyr Val Lys Ile 
1               5                   10                  15      


Arg Ser Arg Lys Leu Gly Ile Phe Arg Arg Cys Trp Leu Val Phe Lys 
            20                  25                  30          


Lys Ala Ser Ser Lys Gly Pro Arg Arg Leu Glu Lys Phe Pro Asp Glu 
        35                  40                  45              


Lys Ala Ala Tyr Phe Arg Asn Phe His Lys Val Thr Glu Leu His Asn 
    50                  55                  60                  


Ile Lys Asn Ile Thr Arg Leu Pro Arg Glu Thr Lys Lys His Ala Val 
65                  70                  75                  80  


Ala Ile Ile Phe His Asp Glu Thr Ser Lys Thr Phe Ala Cys Glu Ser 
                85                  90                  95      


Glu Leu Glu Ala Glu Glu Trp Cys Lys His Leu Cys Met Glu Cys Leu 
            100                 105                 110         


Gly Thr Arg Leu Asn Asp Ile Ser Leu Gly Glu Pro Asp Leu Leu Ala 
        115                 120                 125             


Ala Gly Val Gln Arg Glu Gln Asn Glu Arg Phe Asn Val Tyr Leu Met 
    130                 135                 140                 


Pro Thr Pro Asn Leu Asp Ile Tyr Gly Glu Cys Thr Met Gln Ile Thr 
145                 150                 155                 160 


His Glu Asn Ile Tyr Leu Trp Asp Ile His Asn Ala Lys Val Lys Leu 
                165                 170                 175     


Val Met Trp Pro Leu Ser Ser Leu Arg Arg Tyr Gly Arg Asp Ser Thr 
            180                 185                 190         


Trp Phe Thr Phe Glu Ser Gly Arg Met Cys Asp Thr Gly Glu Gly Leu 
        195                 200                 205             


Phe Thr Phe Gln Thr Arg Glu Gly Glu Met Ile Tyr Gln Lys Val His 
    210                 215                 220                 


Ser Ala Thr Leu Ala Ile Ala Glu Gln His Glu Arg Leu Met Leu Glu 
225                 230                 235                 240 


Met Glu Gln Lys Ala Arg Leu Gln Thr Ser Leu Thr Glu Pro Met Thr 
                245                 250                 255     


Leu Ser Lys Ser Ile Ser Leu Pro Arg Ser Ala Tyr Trp His His Ile 
            260                 265                 270         


Thr Arg Gln Asn Ser Val Gly Glu Ile Tyr Ser Leu Gln Gly His Gly 
        275                 280                 285             


Phe Gly Ser Ser Lys Met Ser Arg Ala Gln Thr Phe Pro Ser Tyr Ala 
    290                 295                 300                 


Pro Glu Gln Ser Glu Glu Ala Gln Gln Pro Leu Ser Arg Ser Ser Ser 
305                 310                 315                 320 


Tyr Gly Phe Ser Tyr Ser Ser Ser Leu Ile Gln 
                325                 330     


<210>  593
<211>  479
<212>  DNA
<213>  Homosapiens

<400>  593
gtgtgccgga tttggttagc tgagcccacc gagaggcgcc tgcaggatga aagctctctg     60

tctcctcctc ctccctgtcc tggggctgtt ggtgtctagc aagaccctgt gctccatgga    120

agaagccatc aatgagagga tccaggaggt cgccggctcc ctaatattta gggcaataag    180

cagcattggc ctggagtgcc agagcgtcac ctccaggggg gacctggcta cttgcccccg    240

aggcttcgcc gtcaccggct gcacttgtgg ctccgcctgt ggctcgtggg atgtgcgcgc    300

cgagaccaca tgtcactgcc agtgcgcggg catggactgg accggagcgc gctgctgtcg    360

tgtgcagccc tgaggtcgcg cgcagcgcgt gcacagcgcg ggcggaggcg gctccaggtc    420

cggaggggtt gcgggggagc tggaaataaa cctggagatg atgatgatga tgatgatgg     479


<210>  594
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  594

Met Lys Ala Leu Cys Leu Leu Leu Leu Pro Val Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Ser Lys Thr Leu Cys Ser Met Glu Glu Ala Ile Asn Glu Arg Ile 
            20                  25                  30          


Gln Glu Val Ala Gly Ser Leu Ile Phe Arg Ala Ile Ser Ser Ile Gly 
        35                  40                  45              


Leu Glu Cys Gln Ser Val Thr Ser Arg Gly Asp Leu Ala Thr Cys Pro 
    50                  55                  60                  


Arg Gly Phe Ala Val Thr Gly Cys Thr Cys Gly Ser Ala Cys Gly Ser 
65                  70                  75                  80  


Trp Asp Val Arg Ala Glu Thr Thr Cys His Cys Gln Cys Ala Gly Met 
                85                  90                  95      


Asp Trp Thr Gly Ala Arg Cys Cys Arg Val Gln Pro 
            100                 105             


<210>  595
<211>  1750
<212>  DNA
<213>  Homosapiens

<400>  595
ggggtggagc tgaggggtgg agctgaggct ggagggagga aggtgtgggg ggacccaggg     60

gtcctgtctc caagcctggt tgctcttacg cgaaaagttg ggacactgag gtgtcacagc    120

ttctcttttg aaatggagag gaggtaggag ggtgaggtcc atccaggtag acacagacac    180

acacagagac cacagcttcc tgtaacattt ccgagtgtcg aattccatct cccggtctag    240

aggtttttct tcttggtcct tcctgagacc tcttggctcc caagagcctc ttgatcgggg    300

caggaatgag ggtgccccag ggtgcgagag tcgtggatcc ctgaaaagag gaggctgctc    360

cccctctttc ttccccccac ctccagattt cctcatctgc ccacaccttc cggtgggcgg    420

ggacgtgtat ggacaaattt gcgggctggg gaccatggaa gtggaggaaa tctacaagca    480

ccaggaagtc aagatgcaag caccagcctt cagggacaag aaacaggggg tctcagccaa    540

gaatcaaggt gcccatgacc cagactatga gaatatcacc ttggccttca aaaatcagga    600

ccatgcaaag ggtggtcatt cacgacccac gagccaagtc ccagcccagt gcaggccgcc    660

ctcagactcc acccaggtcc cctgctggtt gtacagagcc atcctgagcc tgtacatcct    720

cctggccctg gcctttgtcc tctgcatcat cctgtcagcc ttcatcatgg tgaagaatgc    780

tgagatgtcc aaggagctgc tgggctttaa aagggagctt tggaatgtct caaactccgt    840

acaagcatgc gaagagagac agaagagagg ctgggattcc gttcagcaga gcatcaccat    900

ggtcaggagc aagattgata gattagagac gacattagca ggcataaaaa acgttgacac    960

aaaggtacag aaaatcttgg aggtgctgca gaaaatgcca cagtcctcac ctcaataaat   1020

gagaggacat tgtggcagcc aaagccacaa cttggaagat ggggctgcac ctgccaacga   1080

agacgggaaa tgaccccccc cccagcctag tgtgaacctg cccctcgtcc cacgtataga   1140

aaaacctcga gtcatggtga atgagtgtct cggagttgct cgtgtgtgtg tacacctgcg   1200

tgcgtgtgtg tgcgtgtgtg cgcgtgtgtt cgtgtgtgtg cgtgtgtgcg tgcgcgtgtg   1260

tgtgcatttt gcaaagggtg gacatttcag tgtatctccc agaaaggtga tgaatgaata   1320

ggactgagag tcacagtgaa tgtggcatgc atgcctgtgt catgtgacat atgtgagtct   1380

cggcatgtca cggtgggtgg ctgtgtctga gcacctccag cagatgtcac tctgagtgtg   1440

ggtgttggtg acatgcattg cacgggcctg tctccctgtt tgtgtaaaca tactagagta   1500

tactgcggcg tgttttctgt ctacccatgt catggtgggg gagatttatc tccgtacatg   1560

tgggtgtcgc catgtgtgcc ctgtcactat ctgtggctgg gtgaacggct gtgtcattat   1620

gagtgtgccg agttatgcca ccctgtgtgc tcagggcaca tgcacacaga catttatctc   1680

tgcactcaca ttttgtgact tatgaagata aataaagtca agggaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa                                                          1750


<210>  596
<211>  187
<212>  PRT
<213>  Homosapiens

<400>  596

Met Glu Val Glu Glu Ile Tyr Lys His Gln Glu Val Lys Met Gln Ala 
1               5                   10                  15      


Pro Ala Phe Arg Asp Lys Lys Gln Gly Val Ser Ala Lys Asn Gln Gly 
            20                  25                  30          


Ala His Asp Pro Asp Tyr Glu Asn Ile Thr Leu Ala Phe Lys Asn Gln 
        35                  40                  45              


Asp His Ala Lys Gly Gly His Ser Arg Pro Thr Ser Gln Val Pro Ala 
    50                  55                  60                  


Gln Cys Arg Pro Pro Ser Asp Ser Thr Gln Val Pro Cys Trp Leu Tyr 
65                  70                  75                  80  


Arg Ala Ile Leu Ser Leu Tyr Ile Leu Leu Ala Leu Ala Phe Val Leu 
                85                  90                  95      


Cys Ile Ile Leu Ser Ala Phe Ile Met Val Lys Asn Ala Glu Met Ser 
            100                 105                 110         


Lys Glu Leu Leu Gly Phe Lys Arg Glu Leu Trp Asn Val Ser Asn Ser 
        115                 120                 125             


Val Gln Ala Cys Glu Glu Arg Gln Lys Arg Gly Trp Asp Ser Val Gln 
    130                 135                 140                 


Gln Ser Ile Thr Met Val Arg Ser Lys Ile Asp Arg Leu Glu Thr Thr 
145                 150                 155                 160 


Leu Ala Gly Ile Lys Asn Val Asp Thr Lys Val Gln Lys Ile Leu Glu 
                165                 170                 175     


Val Leu Gln Lys Met Pro Gln Ser Ser Pro Gln 
            180                 185         


<210>  597
<211>  923
<212>  DNA
<213>  Homosapiens

<400>  597
atggatgcac ttgagacaat tgaacccatc cccaaggaca taggagtgcc tggaaaagcc     60

aacagcgtgg gccacccaga gccagcgaga ccctggccac gcgcggagca gccatcacgg    120

ccgtgggcca cgtccctggg tccggctccg cggactcgcg cgcccccctg cggccgctct    180

caggcaccgc tgcgcgcgcc ccgcccacac gcctggcccg tcgagcgcct gcgcacgcag    240

cgccttttac ggcgccgtaa agcagctcgg ccgagcagac tgctgcggtt cctgggtggc    300

ggcggcatgg aggcgcgctt cacgcgcggg aagtcggcgc tgctggagcg cgcgctggcg    360

cggccgcgca ccgaggtgag cctgagcgcc ttcgcactgc tgttctccga gctggtacag    420

cactgccaga gccgcgtctt ctccgtggcc gagctgcagt cgcgcctggc cgcgctgggc    480

cgccaggtgg gcgcgcgcgt gctggatgcg ctggtggcgc gcgaaaaggg tgcccggcgt    540

gagaccaagg tgctaggcgc gttgctcttc gtcaagggcg ccgtgtggaa ggcgctcttc    600

ggcaaggagg cggacaagct ggagcaggcc aacgatgacg cgcgcacctt ctacatcatc    660

gagcgcgagc cgctcatcaa cacctacatc tccgtgccca aggagaacag cacgctcaac    720

tgcgccagct tcacggcggg catcgtggag gcggtgctca cacacagcgg cttccctgcc    780

aaggtcacgg cgcactggca caagggcacc acgctcatga tcaagttcga ggaggcagtc    840

atcgctcgag accgggccct ggagggccgc tgaccctgcc ggagataaag gatacagaga    900

gcccctcaaa aaagaaaaaa aaa                                            923


<210>  598
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  598

Met Asp Ala Leu Glu Thr Ile Glu Pro Ile Pro Lys Asp Ile Gly Val 
1               5                   10                  15      


Pro Gly Lys Ala Asn Ser Val Gly His Pro Glu Pro Ala Arg Pro Trp 
            20                  25                  30          


Pro Arg Ala Glu Gln Pro Ser Arg Pro Trp Ala Thr Ser Leu Gly Pro 
        35                  40                  45              


Ala Pro Arg Thr Arg Ala Pro Pro Cys Gly Arg Ser Gln Ala Pro Leu 
    50                  55                  60                  


Arg Ala Pro Arg Pro His Ala Trp Pro Val Glu Arg Leu Arg Thr Gln 
65                  70                  75                  80  


Arg Leu Leu Arg Arg Arg Lys Ala Ala Arg Pro Ser Arg Leu Leu Arg 
                85                  90                  95      


Phe Leu Gly Gly Gly Gly Met Glu Ala Arg Phe Thr Arg Gly Lys Ser 
            100                 105                 110         


Ala Leu Leu Glu Arg Ala Leu Ala Arg Pro Arg Thr Glu Val Ser Leu 
        115                 120                 125             


Ser Ala Phe Ala Leu Leu Phe Ser Glu Leu Val Gln His Cys Gln Ser 
    130                 135                 140                 


Arg Val Phe Ser Val Ala Glu Leu Gln Ser Arg Leu Ala Ala Leu Gly 
145                 150                 155                 160 


Arg Gln Val Gly Ala Arg Val Leu Asp Ala Leu Val Ala Arg Glu Lys 
                165                 170                 175     


Gly Ala Arg Arg Glu Thr Lys Val Leu Gly Ala Leu Leu Phe Val Lys 
            180                 185                 190         


Gly Ala Val Trp Lys Ala Leu Phe Gly Lys Glu Ala Asp Lys Leu Glu 
        195                 200                 205             


Gln Ala Asn Asp Asp Ala Arg Thr Phe Tyr Ile Ile Glu Arg Glu Pro 
    210                 215                 220                 


Leu Ile Asn Thr Tyr Ile Ser Val Pro Lys Glu Asn Ser Thr Leu Asn 
225                 230                 235                 240 


Cys Ala Ser Phe Thr Ala Gly Ile Val Glu Ala Val Leu Thr His Ser 
                245                 250                 255     


Gly Phe Pro Ala Lys Val Thr Ala His Trp His Lys Gly Thr Thr Leu 
            260                 265                 270         


Met Ile Lys Phe Glu Glu Ala Val Ile Ala Arg Asp Arg Ala Leu Glu 
        275                 280                 285             


Gly Arg 
    290 


<210>  599
<211>  1652
<212>  DNA
<213>  Homosapiens

<400>  599
ctgcttaaac ctctgtctct gacggtccct gccaatcgct ctggtcgacc ccaacacact     60

aggaggacag acacaggctc caaactccac taaccagagc tgtgattgtg cccgctgagt    120

ggactgcgtt gtcagggagt gagtgctcca tcatcgggag aatccaagca ggaccgccat    180

ggaggaaggt caatattcag agatcgagga gcttcccagg aggcggtgtt gcaggcgtgg    240

gactcagatc gtgctgctgg ggctggtgac cgccgctctg tgggctgggc tgctgactct    300

gcttctcctg tggcactggg acaccacaca gagtctaaaa cagctggaag agagggctgc    360

ccggaacgtc tctcaagttt ccaagaactt ggaaagccac cacggtgacc agatggcgca    420

gaaatcccag tccacgcaga tttcacagga actggaggaa cttcgagctg aacagcagag    480

attgaaatct caggacttgg agctgtcctg gaacctgaac gggcttcaag cagatctgag    540

cagcttcaag tcccaggaat tgaacgagag gaacgaagct tcagatttgc tggaaagact    600

ccgggaggag gtgacaaagc taaggatgga gttgcaggtg tccagcggct ttgtgtgcaa    660

cacgtgccct gaaaagtgga tcaatttcca acggaagtgc tactacttcg gcaagggcac    720

caagcagtgg gtccacgccc ggtatgcctg tgacgacatg gaagggcagc tggtcagcat    780

ccacagcccg gaggagcagg acttcctgac caagcatgcc agccacaccg gctcctggat    840

tggccttcgg aacttggacc tgaaggggga gtttatctgg gtggatggga gccacgtgga    900

ctacagcaac tgggctccag gggagcccac cagccggagc cagggcgagg actgcgtgat    960

gatgcggggc tccggtcgct ggaacgacgc cttctgcgac cgtaagctgg gcgcctgggt   1020

gtgcgaccgg ctggccacat gcacgccgcc agccagcgaa ggttccgcgg agtccatggg   1080

acctgattca agaccagacc ctgacggccg cctgcccacc ccctctgccc ctctccactc   1140

ttgagcatgg atacagccag gcccagagca agaccctgaa gacccccaac cacggcctaa   1200

aagcctcttt gtggctgaaa ggtccctgtg acattttctg ccacccaaac ggaggcagct   1260

gacacatctc ccgctcctct atggcccctg ccttcccagg agtacacccc aacagcaccc   1320

tctccagatg ggagtgcccc caacagcacc ctctccagat gagagtacac cccaacagca   1380

ccctctccag atgagagtac accccaacag caccctctcc agatgagagt acaccccaac   1440

agcaccctct ccagatgcag ccccatctcc tcagcacccc aggacctgag tatccccagc   1500

tcaggtggtg agtcctcctg tccagcctgc atcaataaaa tggggcagtg atggcctccc   1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 1652


<210>  600
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  600

Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg 
1               5                   10                  15      


Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala 
            20                  25                  30          


Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp 
        35                  40                  45              


Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val 
    50                  55                  60                  


Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala 
65                  70                  75                  80  


Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg 
                85                  90                  95      


Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn 
            100                 105                 110         


Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu 
        115                 120                 125             


Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu 
    130                 135                 140                 


Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys 
145                 150                 155                 160 


Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr 
                165                 170                 175     


Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp 
            180                 185                 190         


Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp 
        195                 200                 205             


Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg 
    210                 215                 220                 


Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val 
225                 230                 235                 240 


Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly 
                245                 250                 255     


Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe 
            260                 265                 270         


Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys 
        275                 280                 285             


Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser 
    290                 295                 300                 


Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His 
305                 310                 315                 320 


Ser 
    


<210>  601
<211>  1837
<212>  DNA
<213>  Homosapiens

<400>  601
acaaccgtaa cagccaccag acaagcttca gtggccggcc cttcacatcc agacttgcct     60

gagaggaccc acctctgagt gtccagtggt cagttgcccc aggatgggga ccacagccag    120

agcagccttg gtcttgacct atttggctgt tgcttctgct gcctctgagg gaggcttcac    180

ggctacagga cagaggcagc tgaggccaga gcactttcaa gaagttggct acgcagctcc    240

cccctcccca cccctatccc gaagcctccc catggatcac cctgactcct ctcagcatgg    300

ccctcccttt gagggacaga gtcaagtgca gccccctccc tctcaggagg ccacccctct    360

ccaacaggaa aagctgctac ctgcccaact ccctgctgaa aaggaagtgg gtccccctct    420

ccctcaggaa gctgtccccc tccaaaaaga gctgccctct ctccagcacc ccaatgaaca    480

gaaggaagga acgccagctc catttgggga ccagagccat ccagaacctg agtcctggaa    540

tgcagcccag cactgccaac aggaccggtc ccaagggggc tggggccacc ggctggatgg    600

cttcccccct gggcggcctt ctccagacaa tctgaaccaa atctgccttc ctaaccgtca    660

gcatgtggta tatggtccct ggaacctacc acagtccagc tactcccacc tcactcgcca    720

gggtgagacc ctcaatttcc tggagattgg atattcccgc tgctgccact gccgcagcca    780

cacaaaccgc ctagagtgtg ccaaacttgt gtgggaggaa gcaatgagcc gattctgtga    840

ggccgagttc tcggtcaaga cccgacccca ctggtgctgc acgcggcagg gggaggctcg    900

gttctcctgc ttccaggagg aagctcccca gccacactac cagctccggg cctgccccag    960

ccatcagcct gatatttcct cgggtcttga gctgcctttc cctcctgggg tgcccacatt   1020

ggacaatatc aagaacatct gccacctgag gcgcttccgc tctgtgccac gcaacctgcc   1080

agctactgac cccctacaaa gggagctgct ggcactgatc cagctggaga gggagttcca   1140

gcgctgctgc cgccagggga acaatcacac ctgtacatgg aaggcctggg aggataccct   1200

tgacaaatac tgtgaccggg agtatgctgt gaagacccac caccacttgt gttgccgcca   1260

ccctcccagc cctactcggg atgagtgctt tgcccgtcgg gctccttacc ccaactatga   1320

ccgggacatc ttgaccattg acatcagtcg agtcaccccc aacctcatgg gccacctctg   1380

tggaaaccaa agagttctca ccaagcataa acatattcct gggctgatcc acaacatgac   1440

tgcccgctgc tgtgacctgc catttccaga acaggcctgc tgtgcagagg aggagaaatt   1500

aaccttcatc aatgatctgt gtggtccccg acgtaacatc tggcgagacc ctgccctctg   1560

ctgttacctg agtcctgggg atgaacaggt caactgcttc aacatcaatt atctgaggaa   1620

cgtggctcta gtgtctggag acactgagaa cgccaagggc cagggggagc agggctcaac   1680

tggaggaaca aatatcagct ccacctctga gcccaaggaa gaatgagtca ccccagagcc   1740

ctagagggtc agatgggggg aaccccaccc tgccccaccc atctgaacac tcattacact   1800

aaacacctct tggatttgga aaaaaaaaaa aaaaaaa                            1837


<210>  602
<211>  540
<212>  PRT
<213>  Homosapiens

<400>  602

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala 
225                 230                 235                 240 


Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His 
                245                 250                 255     


Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu 
            260                 265                 270         


Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln 
        275                 280                 285             


Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro 
    290                 295                 300                 


Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser 
305                 310                 315                 320 


Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu 
                325                 330                 335     


Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly 
            340                 345                 350         


Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys 
        355                 360                 365             


Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys 
    370                 375                 380                 


Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala 
385                 390                 395                 400 


Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Ser Arg 
                405                 410                 415     


Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu 
            420                 425                 430         


Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg 
        435                 440                 445             


Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp 
465                 470                 475                 480 


Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val 
                485                 490                 495     


Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly 
            500                 505                 510         


Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly 
        515                 520                 525             


Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
    530                 535                 540 


<210>  603
<211>  1462
<212>  DNA
<213>  Homosapiens

<400>  603
acaaccgtaa cagccaccag acaagcttca gtggccggcc cttcacatcc agacttgcct     60

gagaggaccc acctctgagt gtccagtggt cagttgcccc aggatgggga ccacagccag    120

agcagccttg gtcttgacct atttggctgt tgcttctgct gcctctgagg gaggcttcac    180

ggctacagga cagaggcagc tgaggccaga gcactttcaa gaagttggct acgcagctcc    240

cccctcccca cccctatccc gaagcctccc catggatcac cctgactcct ctcagcatgg    300

ccctcccttt gagggacaga gtcaagtgca gccccctccc tctcaggagg ccacccctct    360

ccaacaggaa aagctgctac ctgcccaact ccctgctgaa aaggaagtgg gtccccctct    420

ccctcaggaa gctgtccccc tccaaaaaga gctgccctct ctccagcacc ccaatgaaca    480

gaaggaagga acgccagctc catttgggga ccagagccat ccagaacctg agtcctggaa    540

tgcagcccag cactgccaac aggaccggtc ccaagggggc tggggccacc ggctggatgg    600

cttcccccct gggcggcctt ctccagacaa tctgaaccaa atctgccttc ctaaccgtca    660

gcatgtggta tatggtccct ggaacctacc acagtccagc tactcccacc tcactcgcca    720

gggtgagacc ctcaatttcc tggagattgg atattcccgc tgctgccact gccgcagcca    780

cacaaaccgc ctagagtgtg ccaaacttgt gtgggaggat acccttgaca aatactgtga    840

ccgggagtat gctgtgaaga cccaccacca cttgtgttgc cgccaccctc ccagccctac    900

tcgggatgag tgctttgccc gtcgggctcc ttaccccaac tatgaccggg acatcttgac    960

cattgacatc agtcgagtca cccccaacct catgggccac ctctgtggaa accaaagagt   1020

tctcaccaag cataaacata ttcctgggct gatccacaac atgactgccc gctgctgtga   1080

cctgccattt ccagaacagg cctgctgtgc agaggaggag aaattaacct tcatcaatga   1140

tctgtgtggt ccccgacgta acatctggcg agaccctgcc ctctgctgtt acctgagtcc   1200

tggggatgaa caggtcaact gcttcaacat caattatctg aggaacgtgg ctctagtgtc   1260

tggagacact gagaacgcca agggccaggg ggagcagggc tcaactggag gaacaaatat   1320

cagctccacc tctgagccca aggaagaatg agtcacccca gagccctaga gggtcagatg   1380

gggggaaccc caccctgccc cacccatctg aacactcatt acactaaaca cctcttggat   1440

ttggaaaaaa aaaaaaaaaa aa                                            1462


<210>  604
<211>  415
<212>  PRT
<213>  Homosapiens

<400>  604

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Asp Thr 
225                 230                 235                 240 


Leu Asp Lys Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His 
                245                 250                 255     


Leu Cys Cys Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala 
            260                 265                 270         


Arg Arg Ala Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp 
        275                 280                 285             


Ile Ser Arg Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln 
    290                 295                 300                 


Arg Val Leu Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met 
305                 310                 315                 320 


Thr Ala Arg Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala 
                325                 330                 335     


Glu Glu Glu Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg 
            340                 345                 350         


Asn Ile Trp Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp 
        355                 360                 365             


Glu Gln Val Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu 
    370                 375                 380                 


Val Ser Gly Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser 
385                 390                 395                 400 


Thr Gly Gly Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
                405                 410                 415 


<210>  605
<211>  4214
<212>  DNA
<213>  Homosapiens

<400>  605
gggccccagt ggccgccgcg gagcgaggtt gcctggagag agcgcctggg cgcagaaggg     60

ttaacgggcc accgggggct cgcagagcag gagggtgctc tcggacggtg tgtcccccac    120

tgcactcctg aacttggagg acagggtcgc cgcgagggac gcagagagca ccctccacgc    180

ccagatgcct gcgtagtttt tgtgaccagt ccgctcctgc ctccccctgg ggcagtagag    240

ggggagcgat ggagaactgg actggcaggc cctggctgta tctgctgctg cttctgtccc    300

tccctcagct ctgcttggat caggaggtgt tgtccggaca ctctcttcag acacctacag    360

aggagggcca gggccccgaa ggtgtctggg gaccttgggt ccagtgggcc tcttgctccc    420

agccctgcgg ggtgggggtg cagcgcagga gccggacatg tcagctccct acagtgcagc    480

tccacccgag tctgcccctc cctccccggc ccccaagaca tccagaagcc ctcctccccc    540

ggggccaggg tcccagaccc cagacttctc cagaaaccct ccccttgtac aggacacagt    600

ctcggggaag gggtggccca cttcgaggtc ccgcttccca cctagggaga gaggagaccc    660

aggagattcg agcggccagg aggtcccggc ttcgagaccc catcaagcca ggaatgttcg    720

gttatgggag agtgcccttt gcattgccac tgcaccggaa ccgcaggcac cctcggagcc    780

cacccagatc tgagctgtcc ctgatctctt ctagagggga agaggctatt ccgtccccta    840

ctccaagagc agagccattc tccgcaaacg gcagccccca aactgagctc cctcccacag    900

aactgtctgt ccacacccca tccccccaag cagaacctct aagccctgaa actgctcaga    960

cagaggtggc ccccagaacc aggcctgccc ccctacggca tcaccccaga gcccaggcct   1020

ctggcacaga gcccccctca cccacgcact ccttaggaga aggtggcttc ttccgtgcat   1080

cccctcagcc acgaaggcca agttcccagg gttgggccag tccccaggta gcagggagac   1140

gccctgatcc ttttccttcg gtccctcggg gccgaggcca gcagggccaa gggccttggg   1200

gaacgggggg gactcctcac gggccccgcc tggagcctga ccctcagcac ccgggcgcct   1260

ggctgcccct gctgagcaac ggcccccatg ccagctccct ctggagcctc tttgctccca   1320

gtagccctat tccaagatgt tctggggaga gtgaacagct aagagcctgc agccaagcgc   1380

cctgcccccc tgagcagcca gacccccggg ccctgcagtg cgcagccttt aactcccagg   1440

aattcatggg ccagctgtat cagtgggagc ccttcactga agtccagggc tcccagcgct   1500

gtgaactgaa ctgccggccc cgtggcttcc gcttctatgt ccgtcacact gaaaaggtcc   1560

aggatgggac cctgtgtcag cctggagccc ctgacatctg tgtggctgga cgctgtctga   1620

gccccggctg tgatgggatc cttggctctg gcaggcgtcc tgatggctgt ggagtctgtg   1680

ggggtgatga ttctacctgt cgccttgttt cggggaacct cactgaccga gggggccccc   1740

tgggctatca gaagatcttg tggattccag cgggagcctt gcggctccag attgcccagc   1800

tccggcctag ctccaactac ctggcacttc gtggccctgg gggccggtcc atcatcaatg   1860

ggaactgggc tgtggatccc cctgggtcct acagggccgg cgggaccgtc tttcgatata   1920

accgtcctcc cagggaggag ggcaaagggg agagtctgtc ggctgaaggc cccaccaccc   1980

agcctgtgga tgtctatatg atctttcagg aggaaaaccc aggcgttttt tatcagtatg   2040

tcatctcttc acctcctcca atccttgaga accccacccc agagccccct gtcccccagc   2100

ttcagccgga gattctgagg gtggagcccc cacttgctcc ggcaccccgc ccagcccgga   2160

ccccaggcac cctccagcgt caggtgcgga tcccccagat gcccgccccg ccccatccca   2220

ggacacccct ggggtctcca gctgcgtact ggaaacgagt gggacactct gcatgctcag   2280

cgtcctgcgg gaaaggtgtc tggcgcccca ttttcctctg catctcccgt gagtcgggag   2340

aggaactgga tgaacgcagc tgtgccgcgg gtgccaggcc cccagcctcc cctgaaccct   2400

gccacggcac cccatgcccc ccatactggg aggctggcga gtggacatcc tgcagccgct   2460

cctgtggccc cggcacccag caccgccagc tgcagtgccg gcaggaattt ggggggggtg   2520

gctcctcggt gcccccggag cgctgtggac atctcccccg gcccaacatc acccagtctt   2580

gccagctgcg cctctgtggc cattgggaag ttggctctcc ttggagccag tgctccgtgc   2640

ggtgcggccg gggccagaga agccggcagg ttcgctgtgt tgggaacaat ggtgatgaag   2700

tgagcgagca ggagtgtgcg tcaggccccc cgcagccccc cagcagagag gcctgtgaca   2760

tggggccctg tactactgcc tggttccaca gcgactggag ctccaagtgc tcagccgagt   2820

gtgggacggg aatccagcgg cgctctgtgg tctgccttgg gagtggggca gccctcgggc   2880

caggccaggg ggaagcagga gcaggaactg ggcagagctg tccaacagga agccggcccc   2940

ctgacatgcg cgcctgcagc ctggggccct gtgagagaac ttggcgctgg tacacagggc   3000

cctggggtga gtgctcctcc gaatgtggct ctggcacaca gcgtagagac atcatctgtg   3060

tatccaaact ggggacggag ttcaacgtga cttctccgag caactgttct cacctcccca   3120

ggccccctgc cctgcagccc tgtcaagggc aggcctgcca ggaccgatgg ttttccacgc   3180

cctggagccc atgttctcgc tcctgccaag ggggaacgca gacacgggag gtccagtgcc   3240

tgagcaccaa ccagaccctc agcacccgat gccctcctca actgcggccc tccaggaagc   3300

gcccctgtaa cagccaaccc tgcagccagc gccctgatga tcaatgcaag gacagctctc   3360

cacattgccc cctggtggta caggcccggc tctgcgtcta cccctactac acagccacct   3420

gttgccgctc ttgcgcacat gtcctggagc ggtctcccca ggatccctcc tgaaaggggt   3480

ccggggcacc ttcacggttt tctgtgccac catcggtcac ccattgatcg gcccactctg   3540

aaccccctgg ctctccagcc tgtcccagtc tcagcaggga tgtcctccag gtgacagagg   3600

gtggcaaggt gactgacaca aagtgacttt cagggctgtg gtcaggccca tgtggtggtg   3660

tgatgggtgt gtgcacatat gcctcaggtg tgcttttggg actgcatgga tatgtgtgtg   3720

ctcaaacgtg tatcactttt caaaaagagg ttacacagac tgagaaggac aagacctgtt   3780

tccttgagac tttcctaggt ggaaaggaaa gcaagtctgc agttccttgc taatctgagc   3840

tacttagagt gtggtctccc caccaactcc agttttgtgc cctaagcctc atttctcatg   3900

ttcagacctc acatcttcta agccgccctg tgtctctgac cccttctcat ttgcctagta   3960

tctctgcccc tgcctcccta attagctagg gctggggtca gccactgcca atcctgcctt   4020

actcaggaag gcaggaggaa agagactgcc tctccagagc aaggcccagc tgggcagagg   4080

gtgaaaaaga gaaatgtgag catccgctcc cccaccaccc cgcccagccc ctagccccac   4140

tccctgcctc ctgaaatggt tcccacccag aactaattta ttttttatta aagatggtca   4200

tgacaaatga gaaa                                                     4214


<210>  606
<211>  1074
<212>  PRT
<213>  Homosapiens

<400>  606

Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 
            20                  25                  30          


Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 
        35                  40                  45              


Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 
    50                  55                  60                  


Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 
65                  70                  75                  80  


Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 
                85                  90                  95      


Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 
            100                 105                 110         


Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 
        115                 120                 125             


Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 
    130                 135                 140                 


Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 
145                 150                 155                 160 


Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 
                165                 170                 175     


Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 
            180                 185                 190         


Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 
        195                 200                 205             


Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 
    210                 215                 220                 


Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 
225                 230                 235                 240 


Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 
                245                 250                 255     


Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 
            260                 265                 270         


Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 
        275                 280                 285             


Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 
    290                 295                 300                 


Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 
305                 310                 315                 320 


Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 
                325                 330                 335     


Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 
            340                 345                 350         


Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 
        355                 360                 365             


Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 
    370                 375                 380                 


Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 
385                 390                 395                 400 


Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 
                405                 410                 415     


Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 
            420                 425                 430         


His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 
        435                 440                 445             


Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 
    450                 455                 460                 


Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 
465                 470                 475                 480 


Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 
                485                 490                 495     


Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 
            500                 505                 510         


Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 
        515                 520                 525             


Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 
    530                 535                 540                 


Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 
545                 550                 555                 560 


Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 
                565                 570                 575     


Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 
            580                 585                 590         


Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 
        595                 600                 605             


Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 
    610                 615                 620                 


Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 
625                 630                 635                 640 


Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 
                645                 650                 655     


Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 
            660                 665                 670         


His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 
        675                 680                 685             


Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 
    690                 695                 700                 


Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 
705                 710                 715                 720 


Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 
                725                 730                 735     


Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 
            740                 745                 750         


Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 
        755                 760                 765             


Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 
    770                 775                 780                 


His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 
785                 790                 795                 800 


Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 
                805                 810                 815     


Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 
            820                 825                 830         


Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 
        835                 840                 845             


Asp Trp Ser Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg 
    850                 855                 860                 


Arg Ser Val Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln 
865                 870                 875                 880 


Gly Glu Ala Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg 
                885                 890                 895     


Pro Pro Asp Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp 
            900                 905                 910         


Arg Trp Tyr Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser 
        915                 920                 925             


Gly Thr Gln Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu 
    930                 935                 940                 


Phe Asn Val Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro 
945                 950                 955                 960 


Ala Leu Gln Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser 
                965                 970                 975     


Thr Pro Trp Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr 
            980                 985                 990         


Arg Glu Val Gln Cys Leu Ser Thr  Asn Gln Thr Leu Ser  Thr Arg Cys 
        995                 1000                 1005             


Pro Pro  Gln Leu Arg Pro Ser  Arg Lys Arg Pro Cys  Asn Ser Gln 
    1010                 1015                 1020             


Pro Cys  Ser Gln Arg Pro Asp  Asp Gln Cys Lys Asp  Ser Ser Pro 
    1025                 1030                 1035             


His Cys  Pro Leu Val Val Gln  Ala Arg Leu Cys Val  Tyr Pro Tyr 
    1040                 1045                 1050             


Tyr Thr  Ala Thr Cys Cys Arg  Ser Cys Ala His Val  Leu Glu Arg 
    1055                 1060                 1065             


Ser Pro  Gln Asp Pro Ser 
    1070                 


<210>  607
<211>  2903
<212>  DNA
<213>  Homosapiens

<400>  607
gggccccagt ggccgccgcg gagcgaggtt gcctggagag agcgcctggg cgcagaaggg     60

ttaacgggcc accgggggct cgcagagcag gagggtgctc tcggacggtg tgtcccccac    120

tgcactcctg aacttggagg acagggtcgc cgcgagggac gcagagagca ccctccacgc    180

ccagatgcct gcgtagtttt tgtgaccagt ccgctcctgc ctccccctgg ggcagtagag    240

ggggagcgat ggagaactgg actggcaggc cctggctgta tctgctgctg cttctgtccc    300

tccctcagct ctgcttggat caggaggtgt tgtccggaca ctctcttcag acacctacag    360

aggagggcca gggccccgaa ggtgtctggg gaccttgggt ccagtgggcc tcttgctccc    420

agccctgcgg ggtgggggtg cagcgcagga gccggacatg tcagctccct acagtgcagc    480

tccacccgag tctgcccctc cctccccggc ccccaagaca tccagaagcc ctcctccccc    540

ggggccaggg tcccagaccc cagacttctc cagaaaccct ccccttgtac aggacacagt    600

ctcggggaag gggtggccca cttcgaggtc ccgcttccca cctagggaga gaggagaccc    660

aggagattcg agcggccagg aggtcccggc ttcgagaccc catcaagcca ggaatgttcg    720

gttatgggag agtgcccttt gcattgccac tgcaccggaa ccgcaggcac cctcggagcc    780

cacccagatc tgagctgtcc ctgatctctt ctagagggga agaggctatt ccgtccccta    840

ctccaagagc agagccattc tccgcaaacg gcagccccca aactgagctc cctcccacag    900

aactgtctgt ccacacccca tccccccaag cagaacctct aagccctgaa actgctcaga    960

cagaggtggc ccccagaacc aggcctgccc ccctacggca tcaccccaga gcccaggcct   1020

ctggcacaga gcccccctca cccacgcact ccttaggaga aggtggcttc ttccgtgcat   1080

cccctcagcc acgaaggcca agttcccagg gttgggccag tccccaggta gcagggagac   1140

gccctgatcc ttttccttcg gtccctcggg gccgaggcca gcagggccaa gggccttggg   1200

gaacgggggg gactcctcac gggccccgcc tggagcctga ccctcagcac ccgggcgcct   1260

ggctgcccct gctgagcaac ggcccccatg ccagctccct ctggagcctc tttgctccca   1320

gtagccctat tccaagatgt tctggggaga gtgaacagct aagagcctgc agccaagcgc   1380

cctgcccccc tgagcagcca gacccccggg ccctgcagtg cgcagccttt aactcccagg   1440

aattcatggg ccagctgtat cagtgggagc ccttcactga agtccagggc tcccagcgct   1500

gtgaactgaa ctgccggccc cgtggcttcc gcttctatgt ccgtcacact gaaaaggtcc   1560

aggatgggac cctgtgtcag cctggagccc ctgacatctg tgtggctgga cgctgtctga   1620

gccccggctg tgatgggatc cttggctctg gcaggcgtcc tgatggctgt ggagtctgtg   1680

ggggtgatga ttctacctgt cgccttgttt cggggaacct cactgaccga gggggccccc   1740

tgggctatca gaagatcttg tggattccag cgggagcctt gcggctccag attgcccagc   1800

tccggcctag ctccaactac ctggcacttc gtggccctgg gggccggtcc atcatcaatg   1860

ggaactgggc tgtggatccc cctgggtcct acagggccgg cgggaccgtc tttcgatata   1920

accgtcctcc cagggaggag ggcaaagggg agagtctgtc ggctgaaggc cccaccaccc   1980

agcctgtgga tgtctatatg atctttcagg aggaaaaccc aggcgttttt tatcagtatg   2040

tcatctcttc acctcctcca atccttgaga accccacccc agagccccct gtcccccagc   2100

ttcagccgga gattctgagg gtggagcccc cacttgctcc ggcaccccgc ccagcccgga   2160

ccccaggcac cctccagcgt caggtgcgga tcccccagat gcccgccccg ccccatccca   2220

ggacacccct ggggtctcca gctgcgtact ggaaacgagt gggacactct gcatgctcag   2280

cgtcctgcgg gaaaggtgtc tggcgcccca ttttcctctg catctcccgt gagtcgggag   2340

aggaactgga tgaacgcagc tgtgccgcgg gtgccaggcc cccagcctcc cctgaaccct   2400

gccacggcac cccatgcccc ccatactggg aggctggcga gtggacatcc tgcagccgct   2460

cctgtggccc cggcacccag caccgccagc tgcagtgccg gcaggaattt ggggggggtg   2520

gctcctcggt gcccccggag cgctgtggac atctcccccg gcccaacatc acccagtctt   2580

gccagctgcg cctctgtggc cattgggaag ttggctctcc ttggagccag tgctccgtgc   2640

ggtgcggccg gggccagaga agccggcagg ttcgctgtgt tgggaacaat ggtgatgaag   2700

tgagcgagca ggagtgtgcg tcaggccccc cgcagccccc cagcagagag gcctgtgaca   2760

tggggccctg tactactgcc tggttccaca gcgactggag ctccaaggtg agcccggaac   2820

ccccagccat atcctgcatc ctgggtaacc acgcccagga cacctcagcc tttccagcat   2880

agctcaataa acttgtattg atc                                           2903


<210>  608
<211>  877
<212>  PRT
<213>  Homosapiens

<400>  608

Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 
            20                  25                  30          


Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 
        35                  40                  45              


Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 
    50                  55                  60                  


Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 
65                  70                  75                  80  


Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 
                85                  90                  95      


Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 
            100                 105                 110         


Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 
        115                 120                 125             


Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 
    130                 135                 140                 


Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 
145                 150                 155                 160 


Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 
                165                 170                 175     


Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 
            180                 185                 190         


Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 
        195                 200                 205             


Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 
    210                 215                 220                 


Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 
225                 230                 235                 240 


Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 
                245                 250                 255     


Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 
            260                 265                 270         


Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 
        275                 280                 285             


Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 
    290                 295                 300                 


Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 
305                 310                 315                 320 


Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 
                325                 330                 335     


Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 
            340                 345                 350         


Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 
        355                 360                 365             


Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 
    370                 375                 380                 


Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 
385                 390                 395                 400 


Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 
                405                 410                 415     


Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 
            420                 425                 430         


His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 
        435                 440                 445             


Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 
    450                 455                 460                 


Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 
465                 470                 475                 480 


Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 
                485                 490                 495     


Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 
            500                 505                 510         


Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 
        515                 520                 525             


Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 
    530                 535                 540                 


Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 
545                 550                 555                 560 


Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 
                565                 570                 575     


Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 
            580                 585                 590         


Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 
        595                 600                 605             


Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 
    610                 615                 620                 


Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 
625                 630                 635                 640 


Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 
                645                 650                 655     


Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 
            660                 665                 670         


His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 
        675                 680                 685             


Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 
    690                 695                 700                 


Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 
705                 710                 715                 720 


Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 
                725                 730                 735     


Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 
            740                 745                 750         


Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 
        755                 760                 765             


Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 
    770                 775                 780                 


His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 
785                 790                 795                 800 


Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 
                805                 810                 815     


Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 
            820                 825                 830         


Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 
        835                 840                 845             


Asp Trp Ser Ser Lys Val Ser Pro Glu Pro Pro Ala Ile Ser Cys Ile 
    850                 855                 860                 


Leu Gly Asn His Ala Gln Asp Thr Ser Ala Phe Pro Ala 
865                 870                 875         


<210>  609
<211>  3772
<212>  DNA
<213>  Homosapiens

<400>  609
caccccgtag gactggccgc cctaaaaccg tgataaagga gctgctcgcc acttctcact     60

tccgcttcct tccagtaagg agtcggggtc ttccccagtt ttctcagcca ggcggcggcg    120

gcgactggca atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc tctactgtgg    180

gggggccggc ttgggggccg gcagcggcgg cgccacccgc ccgggagggc gacttttggc    240

tacggagaag gaggcctcgg cccggcgaga gataggggga ggggaggccg gcgcggtgat    300

tggcggaagc gccggcgcaa gccccccgtc caccctcacg ccagactccc ggagggtcgc    360

gcggccgccg cccattggcg ccgaggtccc cgacgtcacc gcgacccccg cgaggctgct    420

tttcttcgcg cccacccgcc gcgcggcgcc gcttgaggag atggaagccc cggccgctga    480

cgccatcatg tcgcccgaag aggagctgga cgggtacgag ccggagcctc tcgggaagcg    540

gccggctgtc ctgccgctgc tggagttggt cggggaatct ggtaataaca ccagtacgga    600

cgggtcacta ccctcgacgc cgccgccagc agaggaggag gaggacgagt tgtaccggca    660

gtcgctggag attatctctc ggtaccttcg ggagcaggcc accggcgcca aggacacaaa    720

gccaatgggc aggtctgggg ccaccagcag gaaggcgctg gagaccttac gacgggttgg    780

ggatggcgtg cagcgcaacc acgagacggc cttccaagga tgggtttgtg gagttcttcc    840

atgtagagga cctagaaggt ggcatcagga atgtgctgct ggcttttgca ggtgttgctg    900

gagtaggagc tggtttggca tatctaataa gatagcctta ctgtaagtgc aatagttgac    960

ttttaaccaa ccaccaccac caccaaaacc agtttatgca gttggactcc aagctgtaac   1020

ttcctagagt tgcaccctag caacctagcc agaaaagcaa gtggcaagag gattatggct   1080

aacaagaata aatacatggg aagagtgctc cccattgatt gaagagtcac tgtctgaaag   1140

aagcaaagtt cagtttcagc aacaaacaaa ctttgtttgg gaagctatgg aggaggactt   1200

ttagatttag tgaagatggt agggtggaaa gacttaattt ccttgttgag aacaggaaag   1260

tggccagtag ccaggcaagt catagaattg attacccgcc gaattcatta atttactgta   1320

gtgttaagag aagcactaag aatgccagtg acctgtgtaa aagttacaag taatagaact   1380

atgactgtaa gcctcagtac tgtacaaggg aagcttttcc tctctctaat tagctttccc   1440

agtatacttc ttagaaagtc caagtgttca ggacttttat acctgttata ctttggcttg   1500

gtttccatga ttcttacttt attagcctag tttatcacca ataatacttg acggaaggct   1560

cagtaattag ttatgaatat ggatatcctc aattcttaag acagcttgta aatgtatttg   1620

taaaaattgt atatattttt acagaaagtc tatttctttg aaacgaagga agtatcgaat   1680

ttacattagt ttttttcata cccttttgaa ctttgcaact tccgtaatta ggaacctgtt   1740

tcttacagct tttctatgct aaactttgtt ctgttcagtt ctagagtgta tacagaacga   1800

attgatgtgt aactgtatgc agactggttg tagtggaaca aatctgataa ctatgcaggt   1860

ttaaattttc ttatctgatt ttggtaagta ttccttagat aggtttttct ttgaaaacct   1920

gggattgaga ggttgatgaa tggaaattct ttcacttcat tatatgcaag ttttcaataa   1980

ttaggtctaa gtggagtttt aaggttactg atgacttaca aataatgggc tctgattggg   2040

caatactcat ttgagttcct tccatttgac ctaatttaac tggtgaaatt taaagtgaat   2100

tcatgggctc atctttaaag cttttactaa aagattttca gctgaatgga actcattagc   2160

tgtgtgcata taaaaagatc acatcaggtg gatggagaga catttgatcc cttgtttgct   2220

taataaatta taaaatgatg gcttggaaaa gcaggctagt ctaaccatgg tgctattatt   2280

aggcttgctt gttacacaca caggtctaag cctagtatgt caataaagca aatacttact   2340

gttttgtttc tattaatgat tcccaaacct tgttgcaagt ttttgcattg gcatctttgg   2400

atttcagtct tgatgtttgt tctatcagac ttaacctttt atttcctgtc cttccttgaa   2460

attgctgatt gttctgctcc ctctacagat atttatatca attcctacag ctttcccctg   2520

ccatccctga actctttcta gcccttttag attttggcac tgtgaaaccc ctgctggaaa   2580

cctgagtgac cctccctccc caccaagagt ccacagacct ttcatctttc acgaacttga   2640

tcctgttagc aggtggtaat accatgggtg ctgtgacact aacagtcatt gagaggtggg   2700

aggaagtccc ttttccttgg actggtatct tttcaactat tgttttatcc tgtctttggg   2760

ggcaatgtgt caaaagtccc ctcaggaatt ttcagaggaa agaacatttt atgaggcttt   2820

ctctaaagtt tcctttgtat aggagtatgc tcacttaaat ttacagaaag aggtgagctg   2880

tgttaaacct cagagtttaa aagctactga taaactgaag aaagtgtcta tattggaact   2940

agggtcattt gaaagcttca gtctcggaac atgaccttta gtctgtggac tccatttaaa   3000

aataggtatg aataagatga ctaagaatgt aatggggaag aactgccctg cctgcccatc   3060

tcagagccat aaggtcatct ttgctagagc tatttttacc tatgtattta tcgttcttga   3120

tcataagccg cttatttata tcatgtatct ctaaggacct aaaagcactt tatgtagttt   3180

ttaattaatc ttaagatctg gttacggtaa ctaaaaaagc ctgtctgcca aatccagtgg   3240

aaacaagtgc atagatgtga attggttttt aggggcccca cttcccaatt cattaggtat   3300

gactgtggaa atacagacaa ggatcttagt tgatattttg ggcttggggc agtgagggct   3360

taggacaccc caagtggttt gggaaaggag gaggggagtg gtgggtttat agggggagga   3420

ggaggcaggt ggtctaagtg ctgactggct acgtagttcg ggcaaatcct ccaaaaggga   3480

aagggaggat ttgcttagaa ggatggcgct cccagtgact actttttgac ttctgtttgt   3540

cttacgcttc tctcagggaa aaacatgcag tcctctagtg tttcatgtac attctgtggg   3600

gggtgaacac cttggttctg gttaaacagc tgtacttttg atagctgtgc caggaagggt   3660

taggaccaac tacaaattaa tgttggttgt caaatgtagt gtgtttccct aactttctgt   3720

ttttcctgag aaaaaaaaat aaatctttta ttcaaaaaaa aaaaaaaaaa aa           3772


<210>  610
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  610

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Glu Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Trp Val Cys Gly Val Leu Pro Cys Arg Gly 
225                 230                 235                 240 


Pro Arg Arg Trp His Gln Glu Cys Ala Ala Gly Phe Cys Arg Cys Cys 
                245                 250                 255     


Trp Ser Arg Ser Trp Phe Gly Ile Ser Asn Lys Ile Ala Leu Leu 
            260                 265                 270     


<210>  611
<211>  4020
<212>  DNA
<213>  Homosapiens

<400>  611
caccccgtag gactggccgc cctaaaaccg tgataaagga gctgctcgcc acttctcact     60

tccgcttcct tccagtaagg agtcggggtc ttccccagtt ttctcagcca ggcggcggcg    120

gcgactggca atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc tctactgtgg    180

gggggccggc ttgggggccg gcagcggcgg cgccacccgc ccgggagggc gacttttggc    240

tacggagaag gaggcctcgg cccggcgaga gataggggga ggggaggccg gcgcggtgat    300

tggcggaagc gccggcgcaa gccccccgtc caccctcacg ccagactccc ggagggtcgc    360

gcggccgccg cccattggcg ccgaggtccc cgacgtcacc gcgacccccg cgaggctgct    420

tttcttcgcg cccacccgcc gcgcggcgcc gcttgaggag atggaagccc cggccgctga    480

cgccatcatg tcgcccgaag aggagctgga cgggtacgag ccggagcctc tcgggaagcg    540

gccggctgtc ctgccgctgc tggagttggt cggggaatct ggtaataaca ccagtacgga    600

cgggtcacta ccctcgacgc cgccgccagc agaggaggag gaggacgagt tgtaccggca    660

gtcgctggag attatctctc ggtaccttcg ggagcaggcc accggcgcca aggacacaaa    720

gccaatgggc aggtctgggg ccaccagcag gaaggcgctg gagaccttac gacgggttgg    780

ggatggcgtg cagcgcaacc acgagacggc cttccaaggc atgcttcgga aactggacat    840

caaaaacgaa gacgatgtga aatcgttgtc tcgagtgatg atccatgttt tcagcgacgg    900

cgtaacaaac tggggcagga ttgtgactct catttctttt ggtgcctttg tggctaaaca    960

cttgaagacc ataaaccaag aaagctgcat cgaaccatta gcagaaagta tcacagacgt   1020

tctcgtaagg acaaaacggg actggctagt taaacaaaga ggctgggatg ggtttgtgga   1080

gttcttccat gtagaggacc tagaaggtgg catcaggaat gtgctgctgg cttttgcagg   1140

tgttgctgga gtaggagctg gtttggcata tctaataaga tagccttact gtaagtgcaa   1200

tagttgactt ttaaccaacc accaccacca ccaaaaccag tttatgcagt tggactccaa   1260

gctgtaactt cctagagttg caccctagca acctagccag aaaagcaagt ggcaagagga   1320

ttatggctaa caagaataaa tacatgggaa gagtgctccc cattgattga agagtcactg   1380

tctgaaagaa gcaaagttca gtttcagcaa caaacaaact ttgtttggga agctatggag   1440

gaggactttt agatttagtg aagatggtag ggtggaaaga cttaatttcc ttgttgagaa   1500

caggaaagtg gccagtagcc aggcaagtca tagaattgat tacccgccga attcattaat   1560

ttactgtagt gttaagagaa gcactaagaa tgccagtgac ctgtgtaaaa gttacaagta   1620

atagaactat gactgtaagc ctcagtactg tacaagggaa gcttttcctc tctctaatta   1680

gctttcccag tatacttctt agaaagtcca agtgttcagg acttttatac ctgttatact   1740

ttggcttggt ttccatgatt cttactttat tagcctagtt tatcaccaat aatacttgac   1800

ggaaggctca gtaattagtt atgaatatgg atatcctcaa ttcttaagac agcttgtaaa   1860

tgtatttgta aaaattgtat atatttttac agaaagtcta tttctttgaa acgaaggaag   1920

tatcgaattt acattagttt ttttcatacc cttttgaact ttgcaacttc cgtaattagg   1980

aacctgtttc ttacagcttt tctatgctaa actttgttct gttcagttct agagtgtata   2040

cagaacgaat tgatgtgtaa ctgtatgcag actggttgta gtggaacaaa tctgataact   2100

atgcaggttt aaattttctt atctgatttt ggtaagtatt ccttagatag gtttttcttt   2160

gaaaacctgg gattgagagg ttgatgaatg gaaattcttt cacttcatta tatgcaagtt   2220

ttcaataatt aggtctaagt ggagttttaa ggttactgat gacttacaaa taatgggctc   2280

tgattgggca atactcattt gagttccttc catttgacct aatttaactg gtgaaattta   2340

aagtgaattc atgggctcat ctttaaagct tttactaaaa gattttcagc tgaatggaac   2400

tcattagctg tgtgcatata aaaagatcac atcaggtgga tggagagaca tttgatccct   2460

tgtttgctta ataaattata aaatgatggc ttggaaaagc aggctagtct aaccatggtg   2520

ctattattag gcttgcttgt tacacacaca ggtctaagcc tagtatgtca ataaagcaaa   2580

tacttactgt tttgtttcta ttaatgattc ccaaaccttg ttgcaagttt ttgcattggc   2640

atctttggat ttcagtcttg atgtttgttc tatcagactt aaccttttat ttcctgtcct   2700

tccttgaaat tgctgattgt tctgctccct ctacagatat ttatatcaat tcctacagct   2760

ttcccctgcc atccctgaac tctttctagc ccttttagat tttggcactg tgaaacccct   2820

gctggaaacc tgagtgaccc tccctcccca ccaagagtcc acagaccttt catctttcac   2880

gaacttgatc ctgttagcag gtggtaatac catgggtgct gtgacactaa cagtcattga   2940

gaggtgggag gaagtccctt ttccttggac tggtatcttt tcaactattg ttttatcctg   3000

tctttggggg caatgtgtca aaagtcccct caggaatttt cagaggaaag aacattttat   3060

gaggctttct ctaaagtttc ctttgtatag gagtatgctc acttaaattt acagaaagag   3120

gtgagctgtg ttaaacctca gagtttaaaa gctactgata aactgaagaa agtgtctata   3180

ttggaactag ggtcatttga aagcttcagt ctcggaacat gacctttagt ctgtggactc   3240

catttaaaaa taggtatgaa taagatgact aagaatgtaa tggggaagaa ctgccctgcc   3300

tgcccatctc agagccataa ggtcatcttt gctagagcta tttttaccta tgtatttatc   3360

gttcttgatc ataagccgct tatttatatc atgtatctct aaggacctaa aagcacttta   3420

tgtagttttt aattaatctt aagatctggt tacggtaact aaaaaagcct gtctgccaaa   3480

tccagtggaa acaagtgcat agatgtgaat tggtttttag gggccccact tcccaattca   3540

ttaggtatga ctgtggaaat acagacaagg atcttagttg atattttggg cttggggcag   3600

tgagggctta ggacacccca agtggtttgg gaaaggagga ggggagtggt gggtttatag   3660

ggggaggagg aggcaggtgg tctaagtgct gactggctac gtagttcggg caaatcctcc   3720

aaaagggaaa gggaggattt gcttagaagg atggcgctcc cagtgactac tttttgactt   3780

ctgtttgtct tacgcttctc tcagggaaaa acatgcagtc ctctagtgtt tcatgtacat   3840

tctgtggggg gtgaacacct tggttctggt taaacagctg tacttttgat agctgtgcca   3900

ggaagggtta ggaccaacta caaattaatg ttggttgtca aatgtagtgt gtttccctaa   3960

ctttctgttt ttcctgagaa aaaaaaataa atcttttatt caaaaaaaaa aaaaaaaaaa   4020


<210>  612
<211>  350
<212>  PRT
<213>  Homosapiens

<400>  612

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Glu Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 


Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     


Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         


Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             


Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 


Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 


Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     


Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 


<210>  613
<211>  1252
<212>  DNA
<213>  Homosapiens

<400>  613
tcgcaacgtc acgggcaagg gccgccattt tgactgagca accctagtga caggagccga     60

agcagcagcg caggttgtcc ccgtttcccc tcccccttcc cttctccggt tgccttcccg    120

ggccccttac actccacagt cccggtcccg ccatgtccca gaaacaagaa gaagagaacc    180

ctgcggagga gaccggcgag gagaagcagg acacgcagga gaaagaaggt attctgcctg    240

agagagctga agaggcaaag ctaaaggcca aatacccaag cctaggacaa aagcctggag    300

gctccgactt cctcatgaag agactccaga aagggcaaaa gtactttgac tcaggagact    360

acaacatggc caaagccaag atgaagaata agcagctgcc aagtgcagga ccagacaaga    420

acctggtgac tggtgatcac atccccaccc cacaggatct gccccagaga aagtcctcgc    480

tcgtcaccag caagcttgcg ggtggccaag ttgaatgatg ctgcccgggg ctctgccaga    540

tcctgagacg cttcccctcc ctgccccacc cgggtcctgt gctggctcct gccccttcct    600

gcttttgcag ccaggggtca ggaggtggct cgggtgtggg ctggagaggc agaagccctt    660

tcctgttggt gtcccagcac atggagcccc ttgggctgag caccaagacc ttgaaccttt    720

tttgttttac cttttttcca aataacagtt gggagaaata tcaatgaaat tctgggggtg    780

ggggtggggt tgaaagggtg gggtgggaga tatggaggag tatgaattag ggcttggagt    840

tggtaaaaac attcctgact atccttctta accacgtggc tgatgtgggg taggtatgag    900

gggaaggaag tggagtagcc taatgaaaag gggttctagt tgagctctgt agataaatgc    960

cttgtttcag tgtggttgga gacctggtgt cagataaaag aaactccatc cgcacagaca   1020

gatgcaaaca gctcctctag ttctgcagag ctagttgaga actcaacatt aatcatttta   1080

aaaagtactg tccttgaaat agatttgctg tgggaagaag ggcagtgagt gtgggagaaa   1140

ggagccgtga gcgtggggaa ccccacagag cccaaaggac tttttcagta ttcgaaataa   1200

acaaaacaaa aacccatgaa aaaacccaac ccagaaataa aaaaaaaaaa aa           1252


<210>  614
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  614

Met Ser Gln Lys Gln Glu Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu 
1               5                   10                  15      


Glu Lys Gln Asp Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Glu Ala Lys Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro 
        35                  40                  45              


Gly Gly Ser Asp Phe Leu Met Lys Arg Leu Gln Lys Gly Gln Lys Tyr 
    50                  55                  60                  


Phe Asp Ser Gly Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys 
65                  70                  75                  80  


Gln Leu Pro Ser Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His 
                85                  90                  95      


Ile Pro Thr Pro Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr 
            100                 105                 110         


Ser Lys Leu Ala Gly Gly Gln Val Glu 
        115                 120     


<210>  615
<211>  1300
<212>  DNA
<213>  Homosapiens

<400>  615
tcgcaacgtc acgggcaagg gccgccattt tgactgagca accctagtga caggagccga     60

agcagcagcg caggttgtcc ccgtttcccc tcccccttcc cttctccggt tgccttcccg    120

ggccccttac actccacagt cccggtcccg ccatgtccca gaaacaagaa gaagagaacc    180

ctgcggagga gaccggcgag gagaagcagg acacgcagga gaaagaaggt attctgcctg    240

agagagctga agaggcaaag ctaaaggcca aatacccaag cctaggacaa aagcctggag    300

gctccgactt cctcatgaag agactccaga aaggggatta taaatcatta cattggagtg    360

tgcttctctg tgcggatgaa atgcaaaagt actttgactc aggagactac aacatggcca    420

aagccaagat gaagaataag cagctgccaa gtgcaggacc agacaagaac ctggtgactg    480

gtgatcacat ccccacccca caggatctgc cccagagaaa gtcctcgctc gtcaccagca    540

agcttgcggg tggccaagtt gaatgatgct gcccggggct ctgccagatc ctgagacgct    600

tcccctccct gccccacccg ggtcctgtgc tggctcctgc cccttcctgc ttttgcagcc    660

aggggtcagg aggtggctcg ggtgtgggct ggagaggcag aagccctttc ctgttggtgt    720

cccagcacat ggagcccctt gggctgagca ccaagacctt gaaccttttt tgttttacct    780

tttttccaaa taacagttgg gagaaatatc aatgaaattc tgggggtggg ggtggggttg    840

aaagggtggg gtgggagata tggaggagta tgaattaggg cttggagttg gtaaaaacat    900

tcctgactat ccttcttaac cacgtggctg atgtggggta ggtatgaggg gaaggaagtg    960

gagtagccta atgaaaaggg gttctagttg agctctgtag ataaatgcct tgtttcagtg   1020

tggttggaga cctggtgtca gataaaagaa actccatccg cacagacaga tgcaaacagc   1080

tcctctagtt ctgcagagct agttgagaac tcaacattaa tcattttaaa aagtactgtc   1140

cttgaaatag atttgctgtg ggaagaaggg cagtgagtgt gggagaaagg agccgtgagc   1200

gtggggaacc ccacagagcc caaaggactt tttcagtatt cgaaataaac aaaacaaaaa   1260

cccatgaaaa aacccaaccc agaaataaaa aaaaaaaaaa                         1300


<210>  616
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  616

Met Ser Gln Lys Gln Glu Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu 
1               5                   10                  15      


Glu Lys Gln Asp Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Glu Ala Lys Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro 
        35                  40                  45              


Gly Gly Ser Asp Phe Leu Met Lys Arg Leu Gln Lys Gly Asp Tyr Lys 
    50                  55                  60                  


Ser Leu His Trp Ser Val Leu Leu Cys Ala Asp Glu Met Gln Lys Tyr 
65                  70                  75                  80  


Phe Asp Ser Gly Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys 
                85                  90                  95      


Gln Leu Pro Ser Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His 
            100                 105                 110         


Ile Pro Thr Pro Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr 
        115                 120                 125             


Ser Lys Leu Ala Gly Gly Gln Val Glu 
    130                 135         


<210>  617
<211>  2931
<212>  DNA
<213>  Homosapiens

<400>  617
tcgcaacgtc acgggcaagg gccgccattt tgactgagca accctagtga caggagccga     60

agcagcagcg caggttgtcc ccgtttcccc tcccccttcc cttctccggt tgccttcccg    120

ggccccttac actccacagt cccggtcccg ccatgtccca gaaacaagaa gaagagaacc    180

ctgcggagga gaccggcgag gagaagcagg acacgcagga gaaagaaggt attctgcctg    240

agagagctga agaggcaaag ctaaaggcca aatacccaag cctaggacaa aagcctggag    300

gctccgactt cctcatgaag agactccaga aaggggatta taaatcatta cattggagtg    360

tgcttctctg tgcggatgaa atgcaaaagt actttgactc aggagactac aacatggcca    420

aagccaagat gaagaataag cagctgccaa gtgcaggacc agacaagaac ctggtgactg    480

gtgatcacat ccccacccca caggatctgc cccagagaaa gtcctcgctc gtcaccagca    540

agcttgcggg gtaacctgag cccccctctc ctccccttcc tcaaccactg gacgtttata    600

tattataggc agggatgaaa tgggcaccta gtcagatctt ctcagcttgc tagccagaaa    660

tgactgtgat tctgctgggg gctgctgaga aggtaatgta ggttgaaaag gggctctaag    720

tttatttatt tcgttagatt gacacttcca cacactccct gtagtccagg tagggcccag    780

aaataggaaa ggctaggatt ggataatgct gcaaatgctt tttttgtgtg agaaactgga    840

gagatgtgat ttctcctttt gggagagaat gtcccaaaat tgattaggct gagccttggg    900

aatagtttgg caggtttaac atcccaaggc taacctaacg tagttgggaa aggtagattg    960

aatgagacat gttttctgtg cttctaagtg ttctgtccct taggctgcta ttgcttcatg   1020

tttccattat ggcaggttta gagaatcctt aaaaagaaaa attgacttgc ttgcctaaaa   1080

ctacagtgcc cccttagcct ccattactta gtatctctta cagtttgctc tggctctcaa   1140

ataatataaa gattgatgaa cattattcac agaaaatggg caccttctct ctctcttcca   1200

gcatgttgct tttgaaagta tcatgggata gtgggacgag cactggttta ggagtcaaga   1260

tatctgggtt ctcactctac tcagtcccag cagagctgtt gtataacctt gattaagtca   1320

tttagcctct ctggatttct atttcctcat ctgtaaaata gagttaaatg tatgtaagat   1380

tgattctgat tctgaagtct taactgccag cagaaaaact ccatactgtt cattgtaaaa   1440

ctaaaagtga ggaaggctcg tgggtggtga acctctgctc tgtaatactg ggaaagtact   1500

acagagggga accatttgag ggatacatga ggagagagta aattgaggtt tggggattat   1560

aaattcaggc aagagaacct tatagatatc acagtcttga gggtcaaaaa aaaatactta   1620

ggaagctagc catggaagct tcttgcctct gacccagccc actttcccag cctacctctg   1680

ggccttagct gctaaaaagc ttctctggca gcggagctgc aggcctgagg aaacatgctc   1740

agtcatgcac atgtgttgac ccatgtttca gatgcagtct gatgccaggt atattgttag   1800

ggaaagagga agaagggtaa actgagctag cccctggggc tgagtactcc tgcagggctg   1860

gaggaacagg ttcttagaag atgattcacc ttggaggaag ctggggaaag tggttaggga   1920

gggagaggag gaagactgag aaatctctgc atccccagaa ctcagcaacc cagctctttt   1980

atcatgagga gaggtagcca tgctgactca tgaacaggtg gaggaaaggg gttgcaggtg   2040

accagcatct tcaatctagt taccaccagc ttggctagaa ttttattgaa cgcaacttgc   2100

tagttatgac agagaggacc agggtgagaa ctaatgctca agagagcaag attctgtaat   2160

cctcttgccc tctcacatca caaattctga tatgccaaac atttggccca atgagaatga   2220

ctgatagact tgctgatgtg catgtggggg gatgaggtgt gtatatgcct ttctcctgac   2280

tggccattca gtgttcaggc tgtcattcaa attggatagg agaaagttgg tgaggaagga   2340

atggagagag caggatccct ggactccctg gtccccaaac tccttgactg tcacttgtaa   2400

ttgtatataa tttttgtgtt tcttgctcca tttcctcatg ctgtcatcct taaagtccat   2460

ctgggaaggg gaaaatgctg aacaccattg tatagtttct tcaactgtcc cagccatgtt   2520

gtacatagat atgtcatgtt attatatata taaatatata tataattttg tacgttttct   2580

tcatctccga tcttctcaaa ttctgtactt tttttctttt ctgtctgagc tgccttctct   2640

atcattcagc ttgagtcctc aagactactg gtcacaatga gtctgatttt taggaaggaa   2700

taggaggagc agggaaatca gaaaaactgt tggtctcact ctgtctctct acctggtcat   2760

cttcaaggct aagaaaacaa acaagctaca ttctgtattt gccagtttcc acagcatgaa   2820

gtacatagct tccttagcaa ggagtggtca ttccaaaatc caaatgcaaa ttgctttgat   2880

taaacctaga ttattaaatc cattcagaac agcaaaaaaa aaaaaaaaaa a            2931


<210>  618
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  618

Met Ser Gln Lys Gln Glu Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu 
1               5                   10                  15      


Glu Lys Gln Asp Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Glu Ala Lys Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro 
        35                  40                  45              


Gly Gly Ser Asp Phe Leu Met Lys Arg Leu Gln Lys Gly Asp Tyr Lys 
    50                  55                  60                  


Ser Leu His Trp Ser Val Leu Leu Cys Ala Asp Glu Met Gln Lys Tyr 
65                  70                  75                  80  


Phe Asp Ser Gly Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys 
                85                  90                  95      


Gln Leu Pro Ser Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His 
            100                 105                 110         


Ile Pro Thr Pro Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr 
        115                 120                 125             


Ser Lys Leu Ala Gly 
    130             


<210>  619
<211>  2883
<212>  DNA
<213>  Homosapiens

<400>  619
tcgcaacgtc acgggcaagg gccgccattt tgactgagca accctagtga caggagccga     60

agcagcagcg caggttgtcc ccgtttcccc tcccccttcc cttctccggt tgccttcccg    120

ggccccttac actccacagt cccggtcccg ccatgtccca gaaacaagaa gaagagaacc    180

ctgcggagga gaccggcgag gagaagcagg acacgcagga gaaagaaggt attctgcctg    240

agagagctga agaggcaaag ctaaaggcca aatacccaag cctaggacaa aagcctggag    300

gctccgactt cctcatgaag agactccaga aagggcaaaa gtactttgac tcaggagact    360

acaacatggc caaagccaag atgaagaata agcagctgcc aagtgcagga ccagacaaga    420

acctggtgac tggtgatcac atccccaccc cacaggatct gccccagaga aagtcctcgc    480

tcgtcaccag caagcttgcg gggtaacctg agcccccctc tcctcccctt cctcaaccac    540

tggacgttta tatattatag gcagggatga aatgggcacc tagtcagatc ttctcagctt    600

gctagccaga aatgactgtg attctgctgg gggctgctga gaaggtaatg taggttgaaa    660

aggggctcta agtttattta tttcgttaga ttgacacttc cacacactcc ctgtagtcca    720

ggtagggccc agaaatagga aaggctagga ttggataatg ctgcaaatgc tttttttgtg    780

tgagaaactg gagagatgtg atttctcctt ttgggagaga atgtcccaaa attgattagg    840

ctgagccttg ggaatagttt ggcaggttta acatcccaag gctaacctaa cgtagttggg    900

aaaggtagat tgaatgagac atgttttctg tgcttctaag tgttctgtcc cttaggctgc    960

tattgcttca tgtttccatt atggcaggtt tagagaatcc ttaaaaagaa aaattgactt   1020

gcttgcctaa aactacagtg cccccttagc ctccattact tagtatctct tacagtttgc   1080

tctggctctc aaataatata aagattgatg aacattattc acagaaaatg ggcaccttct   1140

ctctctcttc cagcatgttg cttttgaaag tatcatggga tagtgggacg agcactggtt   1200

taggagtcaa gatatctggg ttctcactct actcagtccc agcagagctg ttgtataacc   1260

ttgattaagt catttagcct ctctggattt ctatttcctc atctgtaaaa tagagttaaa   1320

tgtatgtaag attgattctg attctgaagt cttaactgcc agcagaaaaa ctccatactg   1380

ttcattgtaa aactaaaagt gaggaaggct cgtgggtggt gaacctctgc tctgtaatac   1440

tgggaaagta ctacagaggg gaaccatttg agggatacat gaggagagag taaattgagg   1500

tttggggatt ataaattcag gcaagagaac cttatagata tcacagtctt gagggtcaaa   1560

aaaaaatact taggaagcta gccatggaag cttcttgcct ctgacccagc ccactttccc   1620

agcctacctc tgggccttag ctgctaaaaa gcttctctgg cagcggagct gcaggcctga   1680

ggaaacatgc tcagtcatgc acatgtgttg acccatgttt cagatgcagt ctgatgccag   1740

gtatattgtt agggaaagag gaagaagggt aaactgagct agcccctggg gctgagtact   1800

cctgcagggc tggaggaaca ggttcttaga agatgattca ccttggagga agctggggaa   1860

agtggttagg gagggagagg aggaagactg agaaatctct gcatccccag aactcagcaa   1920

cccagctctt ttatcatgag gagaggtagc catgctgact catgaacagg tggaggaaag   1980

gggttgcagg tgaccagcat cttcaatcta gttaccacca gcttggctag aattttattg   2040

aacgcaactt gctagttatg acagagagga ccagggtgag aactaatgct caagagagca   2100

agattctgta atcctcttgc cctctcacat cacaaattct gatatgccaa acatttggcc   2160

caatgagaat gactgataga cttgctgatg tgcatgtggg gggatgaggt gtgtatatgc   2220

ctttctcctg actggccatt cagtgttcag gctgtcattc aaattggata ggagaaagtt   2280

ggtgaggaag gaatggagag agcaggatcc ctggactccc tggtccccaa actccttgac   2340

tgtcacttgt aattgtatat aatttttgtg tttcttgctc catttcctca tgctgtcatc   2400

cttaaagtcc atctgggaag gggaaaatgc tgaacaccat tgtatagttt cttcaactgt   2460

cccagccatg ttgtacatag atatgtcatg ttattatata tataaatata tatataattt   2520

tgtacgtttt cttcatctcc gatcttctca aattctgtac tttttttctt ttctgtctga   2580

gctgccttct ctatcattca gcttgagtcc tcaagactac tggtcacaat gagtctgatt   2640

tttaggaagg aataggagga gcagggaaat cagaaaaact gttggtctca ctctgtctct   2700

ctacctggtc atcttcaagg ctaagaaaac aaacaagcta cattctgtat ttgccagttt   2760

ccacagcatg aagtacatag cttccttagc aaggagtggt cattccaaaa tccaaatgca   2820

aattgctttg attaaaccta gattattaaa tccattcaga acagcaaaaa aaaaaaaaaa   2880

aaa                                                                 2883


<210>  620
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  620

Met Ser Gln Lys Gln Glu Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu 
1               5                   10                  15      


Glu Lys Gln Asp Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Glu Ala Lys Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro 
        35                  40                  45              


Gly Gly Ser Asp Phe Leu Met Lys Arg Leu Gln Lys Gly Gln Lys Tyr 
    50                  55                  60                  


Phe Asp Ser Gly Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys 
65                  70                  75                  80  


Gln Leu Pro Ser Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His 
                85                  90                  95      


Ile Pro Thr Pro Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr 
            100                 105                 110         


Ser Lys Leu Ala Gly 
        115         


<210>  621
<211>  2747
<212>  DNA
<213>  Homosapiens

<400>  621
ggttggaaag acggtgaatg gaaaggggat ggctggtggt cttgggtgtg atgtgtgtta     60

ttggtttgta gaggacacgc aggagaaaga aggtattctg cctgagagag ctgaagaggc    120

aaagctaaag gccaaatacc caagcctagg acaaaagcct ggaggctccg acttcctcat    180

gaagagactc cagaaagggc aaaagtactt tgactcagga gactacaaca tggccaaagc    240

caagatgaag aataagcagc tgccaagtgc aggaccagac aagaacctgg tgactggtga    300

tcacatcccc accccacagg atctgcccca gagaaagtcc tcgctcgtca ccagcaagct    360

tgcggggtaa cctgagcccc cctctcctcc ccttcctcaa ccactggacg tttatatatt    420

ataggcaggg atgaaatggg cacctagtca gatcttctca gcttgctagc cagaaatgac    480

tgtgattctg ctgggggctg ctgagaaggt aatgtaggtt gaaaaggggc tctaagttta    540

tttatttcgt tagattgaca cttccacaca ctccctgtag tccaggtagg gcccagaaat    600

aggaaaggct aggattggat aatgctgcaa atgctttttt tgtgtgagaa actggagaga    660

tgtgatttct ccttttggga gagaatgtcc caaaattgat taggctgagc cttgggaata    720

gtttggcagg tttaacatcc caaggctaac ctaacgtagt tgggaaaggt agattgaatg    780

agacatgttt tctgtgcttc taagtgttct gtcccttagg ctgctattgc ttcatgtttc    840

cattatggca ggtttagaga atccttaaaa agaaaaattg acttgcttgc ctaaaactac    900

agtgccccct tagcctccat tacttagtat ctcttacagt ttgctctggc tctcaaataa    960

tataaagatt gatgaacatt attcacagaa aatgggcacc ttctctctct cttccagcat   1020

gttgcttttg aaagtatcat gggatagtgg gacgagcact ggtttaggag tcaagatatc   1080

tgggttctca ctctactcag tcccagcaga gctgttgtat aaccttgatt aagtcattta   1140

gcctctctgg atttctattt cctcatctgt aaaatagagt taaatgtatg taagattgat   1200

tctgattctg aagtcttaac tgccagcaga aaaactccat actgttcatt gtaaaactaa   1260

aagtgaggaa ggctcgtggg tggtgaacct ctgctctgta atactgggaa agtactacag   1320

aggggaacca tttgagggat acatgaggag agagtaaatt gaggtttggg gattataaat   1380

tcaggcaaga gaaccttata gatatcacag tcttgagggt caaaaaaaaa tacttaggaa   1440

gctagccatg gaagcttctt gcctctgacc cagcccactt tcccagccta cctctgggcc   1500

ttagctgcta aaaagcttct ctggcagcgg agctgcaggc ctgaggaaac atgctcagtc   1560

atgcacatgt gttgacccat gtttcagatg cagtctgatg ccaggtatat tgttagggaa   1620

agaggaagaa gggtaaactg agctagcccc tggggctgag tactcctgca gggctggagg   1680

aacaggttct tagaagatga ttcaccttgg aggaagctgg ggaaagtggt tagggaggga   1740

gaggaggaag actgagaaat ctctgcatcc ccagaactca gcaacccagc tcttttatca   1800

tgaggagagg tagccatgct gactcatgaa caggtggagg aaaggggttg caggtgacca   1860

gcatcttcaa tctagttacc accagcttgg ctagaatttt attgaacgca acttgctagt   1920

tatgacagag aggaccaggg tgagaactaa tgctcaagag agcaagattc tgtaatcctc   1980

ttgccctctc acatcacaaa ttctgatatg ccaaacattt ggcccaatga gaatgactga   2040

tagacttgct gatgtgcatg tggggggatg aggtgtgtat atgcctttct cctgactggc   2100

cattcagtgt tcaggctgtc attcaaattg gataggagaa agttggtgag gaaggaatgg   2160

agagagcagg atccctggac tccctggtcc ccaaactcct tgactgtcac ttgtaattgt   2220

atataatttt tgtgtttctt gctccatttc ctcatgctgt catccttaaa gtccatctgg   2280

gaaggggaaa atgctgaaca ccattgtata gtttcttcaa ctgtcccagc catgttgtac   2340

atagatatgt catgttatta tatatataaa tatatatata attttgtacg ttttcttcat   2400

ctccgatctt ctcaaattct gtactttttt tcttttctgt ctgagctgcc ttctctatca   2460

ttcagcttga gtcctcaaga ctactggtca caatgagtct gatttttagg aaggaatagg   2520

aggagcaggg aaatcagaaa aactgttggt ctcactctgt ctctctacct ggtcatcttc   2580

aaggctaaga aaacaaacaa gctacattct gtatttgcca gtttccacag catgaagtac   2640

atagcttcct tagcaaggag tggtcattcc aaaatccaaa tgcaaattgc tttgattaaa   2700

cctagattat taaatccatt cagaacagca aaaaaaaaaa aaaaaaa                 2747


<210>  622
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  622

Met Ala Gly Gly Leu Gly Cys Asp Val Cys Tyr Trp Phe Val Glu Asp 
1               5                   10                  15      


Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala Glu Glu Ala Lys 
            20                  25                  30          


Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro Gly Gly Ser Asp 
        35                  40                  45              


Phe Leu Met Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly 
    50                  55                  60                  


Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Ser 
65                  70                  75                  80  


Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His Ile Pro Thr Pro 
                85                  90                  95      


Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr Ser Lys Leu Ala 
            100                 105                 110         


Gly 
    


<210>  623
<211>  771
<212>  DNA
<213>  Homosapiens

<400>  623
tcgcaacgtc acgggcaagg gccgccattt tgactgagca accctagtga caggagccga     60

agcagcagcg caggttgtcc ccgtttcccc tcccccttcc cttctccggt tgccttcccg    120

ggccccttac actccacagt cccggtcccg ccatgtccca gaaacaagaa gaagagaacc    180

ctgcggagga gaccggcgag gagaagcagg acacgcagga gaaagaaggt attctgcctg    240

agagagctga agaggcaaag ctaaaggcca aatacccaag cctaggacaa aagcctggag    300

gctccgactt cctcatgaag agactccaga aaggggtatg gggcatagtc tcttaccctc    360

tttctttgga gctaaaggag gttcttcgaa tgaagtctgt agaggttcta ctggatcctt    420

ttctggaggt tttgttgttg aacagaagta gaggcgaatt tgaaatttga aaagagcaag    480

tcaaattaat gtaaatccct gatgtggtat caattccctc ctgatttccc atgtaggaaa    540

ttaaggccta aattggagca tttgggtgtg tggggaaatg agggaaagat gttagaaact    600

gaaatgcaga ctgcccccag gcatttgcct gtttgaatgt tggaggtttt aggattgtgc    660

actttttaag cattagagat aaattttggg atgcatcatt tcagaagaag atcaaaccat    720

ctctcctaca gaaataaatc ctcaacttga aatgaaaaaa aaaaaaaaaa a             771


<210>  624
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  624

Met Ser Gln Lys Gln Glu Glu Glu Asn Pro Ala Glu Glu Thr Gly Glu 
1               5                   10                  15      


Glu Lys Gln Asp Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala 
            20                  25                  30          


Glu Glu Ala Lys Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro 
        35                  40                  45              


Gly Gly Ser Asp Phe Leu Met Lys Arg Leu Gln Lys Gly Val Trp Gly 
    50                  55                  60                  


Ile Val Ser Tyr Pro Leu Ser Leu Glu Leu Lys Glu Val Leu Arg Met 
65                  70                  75                  80  


Lys Ser Val Glu Val Leu Leu Asp Pro Phe Leu Glu Val Leu Leu Leu 
                85                  90                  95      


Asn Arg Ser Arg Gly Glu Phe Glu Ile 
            100                 105 


<210>  625
<211>  1164
<212>  DNA
<213>  Homosapiens

<400>  625
ggttggaaag acggtgaatg gaaaggggat ggctggtggt cttgggtgtg atgtgtgtta     60

ttggtttgta gaggacacgc aggagaaaga aggtattctg cctgagagag ctgaagaggc    120

aaagctaaag gccaaatacc caagcctagg acaaaagcct ggaggctccg acttcctcat    180

gaagagactc cagaaagggg attataaatc attacattgg agtgtgcttc tctgtgcgga    240

tgaaatgcaa aagtactttg actcaggaga ctacaacatg gccaaagcca agatgaagaa    300

taagcagctg ccaagtgcag gaccagacaa gaacctggtg actggtgatc acatccccac    360

cccacaggat ctgccccaga gaaagtcctc gctcgtcacc agcaagcttg cgggtggcca    420

agttgaatga tgctgcccgg ggctctgcca gatcctgaga cgcttcccct ccctgcccca    480

cccgggtcct gtgctggctc ctgccccttc ctgcttttgc agccaggggt caggaggtgg    540

ctcgggtgtg ggctggagag gcagaagccc tttcctgttg gtgtcccagc acatggagcc    600

ccttgggctg agcaccaaga ccttgaacct tttttgtttt accttttttc caaataacag    660

ttgggagaaa tatcaatgaa attctggggg tgggggtggg gttgaaaggg tggggtggga    720

gatatggagg agtatgaatt agggcttgga gttggtaaaa acattcctga ctatccttct    780

taaccacgtg gctgatgtgg ggtaggtatg aggggaagga agtggagtag cctaatgaaa    840

aggggttcta gttgagctct gtagataaat gccttgtttc agtgtggttg gagacctggt    900

gtcagataaa agaaactcca tccgcacaga cagatgcaaa cagctcctct agttctgcag    960

agctagttga gaactcaaca ttaatcattt taaaaagtac tgtccttgaa atagatttgc   1020

tgtgggaaga agggcagtga gtgtgggaga aaggagccgt gagcgtgggg aaccccacag   1080

agcccaaagg actttttcag tattcgaaat aaacaaaaca aaaacccatg aaaaaaccca   1140

acccagaaat aaaaaaaaaa aaaa                                          1164


<210>  626
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  626

Met Ala Gly Gly Leu Gly Cys Asp Val Cys Tyr Trp Phe Val Glu Asp 
1               5                   10                  15      


Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala Glu Glu Ala Lys 
            20                  25                  30          


Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro Gly Gly Ser Asp 
        35                  40                  45              


Phe Leu Met Lys Arg Leu Gln Lys Gly Asp Tyr Lys Ser Leu His Trp 
    50                  55                  60                  


Ser Val Leu Leu Cys Ala Asp Glu Met Gln Lys Tyr Phe Asp Ser Gly 
65                  70                  75                  80  


Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Ser 
                85                  90                  95      


Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His Ile Pro Thr Pro 
            100                 105                 110         


Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr Ser Lys Leu Ala 
        115                 120                 125             


Gly Gly Gln Val Glu 
    130             


<210>  627
<211>  1116
<212>  DNA
<213>  Homosapiens

<400>  627
ggttggaaag acggtgaatg gaaaggggat ggctggtggt cttgggtgtg atgtgtgtta     60

ttggtttgta gaggacacgc aggagaaaga aggtattctg cctgagagag ctgaagaggc    120

aaagctaaag gccaaatacc caagcctagg acaaaagcct ggaggctccg acttcctcat    180

gaagagactc cagaaagggc aaaagtactt tgactcagga gactacaaca tggccaaagc    240

caagatgaag aataagcagc tgccaagtgc aggaccagac aagaacctgg tgactggtga    300

tcacatcccc accccacagg atctgcccca gagaaagtcc tcgctcgtca ccagcaagct    360

tgcgggtggc caagttgaat gatgctgccc ggggctctgc cagatcctga gacgcttccc    420

ctccctgccc cacccgggtc ctgtgctggc tcctgcccct tcctgctttt gcagccaggg    480

gtcaggaggt ggctcgggtg tgggctggag aggcagaagc cctttcctgt tggtgtccca    540

gcacatggag ccccttgggc tgagcaccaa gaccttgaac cttttttgtt ttaccttttt    600

tccaaataac agttgggaga aatatcaatg aaattctggg ggtgggggtg gggttgaaag    660

ggtggggtgg gagatatgga ggagtatgaa ttagggcttg gagttggtaa aaacattcct    720

gactatcctt cttaaccacg tggctgatgt ggggtaggta tgaggggaag gaagtggagt    780

agcctaatga aaaggggttc tagttgagct ctgtagataa atgccttgtt tcagtgtggt    840

tggagacctg gtgtcagata aaagaaactc catccgcaca gacagatgca aacagctcct    900

ctagttctgc agagctagtt gagaactcaa cattaatcat tttaaaaagt actgtccttg    960

aaatagattt gctgtgggaa gaagggcagt gagtgtggga gaaaggagcc gtgagcgtgg   1020

ggaaccccac agagcccaaa ggactttttc agtattcgaa ataaacaaaa caaaaaccca   1080

tgaaaaaacc caacccagaa ataaaaaaaa aaaaaa                             1116


<210>  628
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  628

Met Ala Gly Gly Leu Gly Cys Asp Val Cys Tyr Trp Phe Val Glu Asp 
1               5                   10                  15      


Thr Gln Glu Lys Glu Gly Ile Leu Pro Glu Arg Ala Glu Glu Ala Lys 
            20                  25                  30          


Leu Lys Ala Lys Tyr Pro Ser Leu Gly Gln Lys Pro Gly Gly Ser Asp 
        35                  40                  45              


Phe Leu Met Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly 
    50                  55                  60                  


Asp Tyr Asn Met Ala Lys Ala Lys Met Lys Asn Lys Gln Leu Pro Ser 
65                  70                  75                  80  


Ala Gly Pro Asp Lys Asn Leu Val Thr Gly Asp His Ile Pro Thr Pro 
                85                  90                  95      


Gln Asp Leu Pro Gln Arg Lys Ser Ser Leu Val Thr Ser Lys Leu Ala 
            100                 105                 110         


Gly Gly Gln Val Glu 
        115         


<210>  629
<211>  3127
<212>  DNA
<213>  Homosapiens

<400>  629
gatgtgttat tccttctctg catcgaagga tcaggaagtt tgtgctctct gcgtggctaa     60

gtttttcacc tactaggacg ggggtggggt ggggagaaca ggtgtccttc taaaatacag    120

cacaagctac agcctgcgtc cagccataac ccaggagtaa catcagaaac aggtgagaat    180

gaccacttta actcaccggg cccgtcgcac tgaaataagc aagaactctg aaaagaagat    240

ggaaagtgag gaagacagta attgggagaa aagtccagac aatgaagatt ctggagactc    300

taaggatatc cgccttactc ttatggaaga agtattgctt ctgggactaa aagataaaga    360

ggggtacaca tctttctgga atgactgcat atcatcaggc ctgcgagggg gcatcctgat    420

agagctggcc atgcggggtc gaatctatct ggaacccccg accatgcgta agaagcgact    480

actagacaga aaggtactgc taaagtcaga cagcccaaca ggtgatgttt tactggatga    540

aactctgaaa cacatcaaag caactgaacc cacagaaact gtccaaacat ggatagagct    600

actcactggt gagacctgga accccttcaa attacagtac cagctgagaa atgtacgaga    660

gcgcatcgca aagaacctag tagagaaagg tattctaacc actgagaagc agaatttcct    720

gctatttgac atgactactc atccagtgac caatacaaca gagaaacagc gactagtgaa    780

aaaacttcaa gatagtgtac tagagcggtg ggtaaatgac cctcagcgta tggacaagcg    840

aacactagca ctcctggtgc tagcccactc ctctgatgtg ctagagaatg tcttctcctc    900

tctgacagat gacaagtatg atgtggcaat gaatcgagcc aaggacttag tagaactgga    960

ccctgaagtg gaagggacaa agcctagtgc cacagaaatg atctgggctg tgctggcagc   1020

cttcaataaa tcttaaagcc ggcaggtgga tttctccttt tcccctgctg gctggtgact   1080

gtcagagacc ccatcactga gttttgtgtg atgagatgtt ttcatcattt ttgtttcctt   1140

ttcttgaatc agacttgtga tttggggaga gcaacttcag ggcttctcca tagaccttga   1200

ccattataag cagaccttat ttctccctac acttccactc cataggtaaa taaactgggt   1260

gaagccacac acacccaatg aacattttct cccatttggt ggtttagttt cacccagtgt   1320

gcttttggat aagcagaaat atctaaatgg gattttgagt tctccagcta tagaatgtga   1380

atgagataaa aagtgaacta tctattatat ttttctgagt ttgttttcta tcataaatac   1440

atgttttcac agcctttgtc tctcagactc tgctaaataa tgtagcttat tgaaataact   1500

gtcgctgaat aaggagcaat gagaaacaaa actaattttt ggagcagatg gtctctggaa   1560

ttgcatatcc tgctagtgat tttctcatct ttccttttct aacctaatga gaatgtccca   1620

gattcaatta cctggatgtc aaagtcctag agccagaaat atattctctc atccctctta   1680

gcattctctt gctccctcat tcactagggc aaatgtctaa atgaagaaaa gtctctctca   1740

acacctcgtt catgcaatca gcattagaat ttgtaaggaa ggaagggggg tggcatgaaa   1800

atttccattc ttggggtata tgactgtcct gtttccccca ggccactttt tttttttttt   1860

tcttttgaga cagggtcttg ctcttgccca ggcaggagta cagtagtgca atcacagctg   1920

actgcagcct tgacctccag ggctcaagga tcctcctgcc tcagtctccc aactaagtgg   1980

gactacaggc acgtgccacc atactcagct tttttttgtt tgttttagac aagagtctcg   2040

ctttgttgcc caggctggtc ttgaattcct gggctcaagc aattcttcca cctcagcctc   2100

ccaaagtgct gagattactg gcttgagcca ctgcacccac ccctccagac tactttaaat   2160

gtctctgctc tgactgaatt gaaggaattg taagtttcag ttgctgaata tatcagtata   2220

tctgaactcc ggatcttttt atttcctatt tttggcttcc tacataaatt aataaagtct   2280

gtctatattt aaggtttctg ggagtagttt tgtctatatt taatccatag atgtgctcct   2340

agtcatcagt cttatttcag taaaaccatc tttctggcca aatctctaac acgtttttta   2400

cttcagtagt gagggcaatg agaagcttta ttaagaaaga tcctatttaa agggctaatt   2460

tggtattgaa agcatgctga tataaagtcc agtatttgag gatataaaga ggatgtgcac   2520

tgagctgtgc tgatgttcag catttattat actttaatgg gatagtgctt cttgaccatt   2580

atagaacaac aaactgtcaa agggttaata cagatgaccc agacctgaca ttaaatcctc   2640

ttgattagaa ataattaaat gaattattta ttcatttctc tcctctgcca aatctactta   2700

gccccacaaa aatgccccag ctcagttaac atttttttgt ttttcacttt aggtatctct   2760

taggcaaata gagatataaa ttgtaatagg aaacagtctc taaatgtgag gctgaataca   2820

gcttcagtct ggctctctaa taggacaaaa gccagtccat gtgttgtctc taactgattt   2880

agctttttct tttctttgaa caattcggca tgaattgaaa ccaggttttc ctgtggaaag   2940

ttatagcttg attgggagat agaagttgaa ttgagttctt tcttgcaact cttagtgttt   3000

atttttatat ctcagtaaga cgaggatacc ttcagtttga atctgcataa tgttcactgc   3060

caaactcctt ctcatttaat gcttatggcc ttcacatttc tgtataataa agatcaatta   3120

tcagctc                                                             3127


<210>  630
<211>  285
<212>  PRT
<213>  Homosapiens

<400>  630

Met Thr Thr Leu Thr His Arg Ala Arg Arg Thr Glu Ile Ser Lys Asn 
1               5                   10                  15      


Ser Glu Lys Lys Met Glu Ser Glu Glu Asp Ser Asn Trp Glu Lys Ser 
            20                  25                  30          


Pro Asp Asn Glu Asp Ser Gly Asp Ser Lys Asp Ile Arg Leu Thr Leu 
        35                  40                  45              


Met Glu Glu Val Leu Leu Leu Gly Leu Lys Asp Lys Glu Gly Tyr Thr 
    50                  55                  60                  


Ser Phe Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Gly Ile Leu 
65                  70                  75                  80  


Ile Glu Leu Ala Met Arg Gly Arg Ile Tyr Leu Glu Pro Pro Thr Met 
                85                  90                  95      


Arg Lys Lys Arg Leu Leu Asp Arg Lys Val Leu Leu Lys Ser Asp Ser 
            100                 105                 110         


Pro Thr Gly Asp Val Leu Leu Asp Glu Thr Leu Lys His Ile Lys Ala 
        115                 120                 125             


Thr Glu Pro Thr Glu Thr Val Gln Thr Trp Ile Glu Leu Leu Thr Gly 
    130                 135                 140                 


Glu Thr Trp Asn Pro Phe Lys Leu Gln Tyr Gln Leu Arg Asn Val Arg 
145                 150                 155                 160 


Glu Arg Ile Ala Lys Asn Leu Val Glu Lys Gly Ile Leu Thr Thr Glu 
                165                 170                 175     


Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Val Thr Asn 
            180                 185                 190         


Thr Thr Glu Lys Gln Arg Leu Val Lys Lys Leu Gln Asp Ser Val Leu 
        195                 200                 205             


Glu Arg Trp Val Asn Asp Pro Gln Arg Met Asp Lys Arg Thr Leu Ala 
    210                 215                 220                 


Leu Leu Val Leu Ala His Ser Ser Asp Val Leu Glu Asn Val Phe Ser 
225                 230                 235                 240 


Ser Leu Thr Asp Asp Lys Tyr Asp Val Ala Met Asn Arg Ala Lys Asp 
                245                 250                 255     


Leu Val Glu Leu Asp Pro Glu Val Glu Gly Thr Lys Pro Ser Ala Thr 
            260                 265                 270         


Glu Met Ile Trp Ala Val Leu Ala Ala Phe Asn Lys Ser 
        275                 280                 285 


<210>  631
<211>  1895
<212>  DNA
<213>  Homosapiens

<400>  631
atgcgcgtcg ggcacagcgc gtgcagcctc gtgcagctct tctggtctcc ggcgcccgcc     60

cctcagacgt aatgttgaat taaagaaaat actttatcag aagaagatgg ccactgccca    120

gttgcagagg actcccatga gtgcactggt atttcccaat aagatatcaa ctgaacacca    180

gtctttggtg ttagtgaaga ggcttctagc agtttcagta tcctgtatca cgtatttgag    240

gggaatattc ccagaatgcg cttatggaac aagatatcta gatgatcttt gtgtcaaaat    300

actgagagaa gataaaaatt gcccaggatc tacacagtta gtgaaatgga tgctaggatg    360

ttatgatgct ttacagaaaa aatatctaag gatggttgtt ctagctgtat acacaaaccc    420

agaagatcct cagacaattt cagaatgtta ccaattcaaa ttcaaataca ccaataatgg    480

accactcatg gacttcataa gtaaaaacca aagcaacgaa tctagcatgt tgtctactga    540

caccaagaaa gcaagcattc tcctcattcg caagatttat atcctaatgc aaaatctggg    600

gcctttacct aatgatgttt gtttgaccat gaaacttttt tactatgatg aagttacacc    660

cccagattac cagcctcccg gttttaagga tggtgattgt gaaggagtta tatttgaagg    720

ggaacctatg tatttaaatg tgggagaagt ctcaacacct tttcacatct tcaaagtaaa    780

agtgaccact gagagagaac gaatggaaaa tattgactca actatactat caccaaaaca    840

aataaaaaca ccatttcaaa aaatcctgag ggacaaagat gtagaagatg aacaggagca    900

ttatacaagt gatgatttgg acattgaaac taaaatggaa gaacaggaaa aaaaccctgc    960

atcttctgaa cttgaagaac caagtttagt ttgtgaggaa gatgaaatta tgaggtctaa   1020

agaaagtcca gatctttcta tttctcattc tcaggttgag cagttagtca ataaaacatc   1080

tgaacttgat atgtctgaaa gcaaaacaag aagtggaaaa gtctttcaga ataaaatggc   1140

aaatggaaat caaccagtaa aatcttccaa agaaaatcgg aagagaagtc aacatgaatc   1200

tgggagaata gtcctccatc actttgattc ttctagtcaa gagtcagtgc caaaaaggag   1260

aaagtttagt gaaccaaagg aacatatata aaaattattt ttgttctgca ggcttgcaga   1320

gttcttctca ccatttaaac tgaaggaccc tatattatat ttccctaact ctgaagatgt   1380

atatgtagtt taaagcagtt tgtacactaa aactaagttt ttggctgact gtcatattgt   1440

ggtccttaat cttgagataa atccaataga acttttgaat aaaagcaaaa gtacaaatgt   1500

cataattgat tcggtaataa gtaaaatttc aaaattgatt ttgttcatta cctacttaat   1560

atttccttta aatatatact aactgttaag gccctctaat gccatttttc taaacagtaa   1620

tgtttacttt ggtattaaaa tttggtatgg attcactttt tacttatgtt aaaattatac   1680

catttaactg gctcttttgt cattgtgctg ttattaaaac aatgttcttc aatattttga   1740

cataatgtat taacatttta atatataatg tacaatttaa gaattggtgc tttaccttta   1800

ctatgctttt ttttacagga caaaaagact gatttttaaa gtatggcatt ttttgcagca   1860

taaataaaat attgttcagc aaaaaaaaaa aaaaa                              1895


<210>  632
<211>  394
<212>  PRT
<213>  Homosapiens

<400>  632

Met Ala Thr Ala Gln Leu Gln Arg Thr Pro Met Ser Ala Leu Val Phe 
1               5                   10                  15      


Pro Asn Lys Ile Ser Thr Glu His Gln Ser Leu Val Leu Val Lys Arg 
            20                  25                  30          


Leu Leu Ala Val Ser Val Ser Cys Ile Thr Tyr Leu Arg Gly Ile Phe 
        35                  40                  45              


Pro Glu Cys Ala Tyr Gly Thr Arg Tyr Leu Asp Asp Leu Cys Val Lys 
    50                  55                  60                  


Ile Leu Arg Glu Asp Lys Asn Cys Pro Gly Ser Thr Gln Leu Val Lys 
65                  70                  75                  80  


Trp Met Leu Gly Cys Tyr Asp Ala Leu Gln Lys Lys Tyr Leu Arg Met 
                85                  90                  95      


Val Val Leu Ala Val Tyr Thr Asn Pro Glu Asp Pro Gln Thr Ile Ser 
            100                 105                 110         


Glu Cys Tyr Gln Phe Lys Phe Lys Tyr Thr Asn Asn Gly Pro Leu Met 
        115                 120                 125             


Asp Phe Ile Ser Lys Asn Gln Ser Asn Glu Ser Ser Met Leu Ser Thr 
    130                 135                 140                 


Asp Thr Lys Lys Ala Ser Ile Leu Leu Ile Arg Lys Ile Tyr Ile Leu 
145                 150                 155                 160 


Met Gln Asn Leu Gly Pro Leu Pro Asn Asp Val Cys Leu Thr Met Lys 
                165                 170                 175     


Leu Phe Tyr Tyr Asp Glu Val Thr Pro Pro Asp Tyr Gln Pro Pro Gly 
            180                 185                 190         


Phe Lys Asp Gly Asp Cys Glu Gly Val Ile Phe Glu Gly Glu Pro Met 
        195                 200                 205             


Tyr Leu Asn Val Gly Glu Val Ser Thr Pro Phe His Ile Phe Lys Val 
    210                 215                 220                 


Lys Val Thr Thr Glu Arg Glu Arg Met Glu Asn Ile Asp Ser Thr Ile 
225                 230                 235                 240 


Leu Ser Pro Lys Gln Ile Lys Thr Pro Phe Gln Lys Ile Leu Arg Asp 
                245                 250                 255     


Lys Asp Val Glu Asp Glu Gln Glu His Tyr Thr Ser Asp Asp Leu Asp 
            260                 265                 270         


Ile Glu Thr Lys Met Glu Glu Gln Glu Lys Asn Pro Ala Ser Ser Glu 
        275                 280                 285             


Leu Glu Glu Pro Ser Leu Val Cys Glu Glu Asp Glu Ile Met Arg Ser 
    290                 295                 300                 


Lys Glu Ser Pro Asp Leu Ser Ile Ser His Ser Gln Val Glu Gln Leu 
305                 310                 315                 320 


Val Asn Lys Thr Ser Glu Leu Asp Met Ser Glu Ser Lys Thr Arg Ser 
                325                 330                 335     


Gly Lys Val Phe Gln Asn Lys Met Ala Asn Gly Asn Gln Pro Val Lys 
            340                 345                 350         


Ser Ser Lys Glu Asn Arg Lys Arg Ser Gln His Glu Ser Gly Arg Ile 
        355                 360                 365             


Val Leu His His Phe Asp Ser Ser Ser Gln Glu Ser Val Pro Lys Arg 
    370                 375                 380                 


Arg Lys Phe Ser Glu Pro Lys Glu His Ile 
385                 390                 


<210>  633
<211>  4100
<212>  DNA
<213>  Homosapiens

<400>  633
gtacctcatg tgacaagttc caatttcttt tcaagtcaat tgaactgaaa tctccttgtt     60

gctttgaaat cttagaagag agcccactaa ttcaaggact cttactgtgg gagcaactgc    120

tggttctatc acaatgaaac ggctggtttg tgtgctcttg gtgtgctcct ctgcagtggc    180

acagttgcat aaagatccta ccctggatca ccactggcat ctctggaaga aaacctatgg    240

caaacaatac aaggaaaaga atgaagaagc agtacgacgt ctcatctggg aaaagaatct    300

aaagtttgtg atgcttcaca acctggagca ttcaatggga atgcactcat acgatctggg    360

catgaaccac ctgggagaca tgaccagtga agaagtgatg tctttgatga gttccctgag    420

agttcccagc cagtggcaga gaaatatcac atataagtca aaccctaatc ggatattgcc    480

tgattctgtg gactggagag agaaagggtg tgttactgaa gtgaaatatc aaggttcttg    540

tggtgcttgc tgggctttca gtgctgtggg ggccctggaa gcacagctga agctgaaaac    600

aggaaagctg gtgtctctca gtgcccagaa cctggtggat tgctcaactg aaaaatatgg    660

aaacaaaggc tgcaatggtg gcttcatgac aacggctttc cagtacatca ttgataacaa    720

gggcatcgac tcagacgctt cctatcccta caaagccatg gatcagaaat gtcaatatga    780

ctcaaaatat cgtgctgcca catgttcaaa gtacactgaa cttccttatg gcagagaaga    840

tgtcctgaaa gaagctgtgg ccaataaagg cccagtgtct gttggtgtag atgcgcgtca    900

tccttctttc ttcctctaca gaagtggtgt ctactatgaa ccatcctgta ctcagaatgt    960

gaatcatggt gtacttgtgg ttggctatgg tgatcttaat gggaaagaat actggcttgt   1020

gaaaaacagc tggggccaca actttggtga agaaggatat attcggatgg caagaaataa   1080

aggaaatcat tgtgggattg ctagctttcc ctcttaccca gaaatctaga ggatctctcc   1140

tttttataac aaatcaagaa atatgaagca ctttctctta acttaatttt tcctgctgta   1200

tccagaagaa ataattgtgt catgattaat gtgtatttac tgtactaatt agaaaatata   1260

gtttgaggcc gggcacggtg gctcacgcct gtaatcccag tacttgggag gccaaggcag   1320

gcatatcaac ttgaggccag gagttaaaga gcagcctggc taacatggtg aaaccccatc   1380

tctactaaaa atacaaaaaa ttagccgagc acggtggtgc atgcctgtaa tcccagctac   1440

ttgggaggct gaggcacgag attccttgaa cccaagaggt tgaggctatg ttgagctgag   1500

atcacaccac tgtactccag cctggatgac agagtggaga ctctgtttca aaaaaacaga   1560

aaagaaaata tagtttgatt cttcattttt ttaaatttgc aaatctcagg ataaagtttg   1620

ctaagtaaat tagtaatgta ctatagatat aactgtacaa aaattgttca acctaaaaca   1680

atctgtaatt gcttattgtt ttattgtata ctctttgtct ttttaagacc cctaatagcc   1740

ttttgtaact tgatggctta aaaatactta ataaatctgc catttcaaat ttctatcatt   1800

gccacatacc attcttattc ctaggcaact attaataatc tatcctgaga atattaattg   1860

tggtattctg gtgatggggt ttagcaactt tgatggaaga aaatattagg ctataaatgt   1920

cctaaggact cagattgtat ctttgtacag aagaggattc aaaacgccac gtgtagtggc   1980

tcatgcctgt aatcccaaca ctttgggagg ctgaagtagg aggatcgtct tgagcccagg   2040

agttcaagac cagcctggac aacatagtga gaccttgtct ccacaaaaat aaaaaagaaa   2100

ctatccagga gtggtggtgt gtgcctgtgg tccctgctat gcagatgtct aagacaggag   2160

gatcacaaga gcccaggagg ttgagaatgc agtgagcttg taattgcacc actgcactcc   2220

agcctgggtg acagagcaag accctgtctt aaaaaaagag gattcaacac atatttttat   2280

attatgttaa agtaaagaaa tgcataaaag acaagcactt tggaagaatt attttaatga   2340

tcaacaattt aatgtattag tccaaattat ttttacgtag tcatcaacaa tttgaccagg   2400

gcctttattt ggcaaataac tgagccaacc agaataaaat aaccaatact ccactgctca   2460

tatttttatc taattcagat ggatcttcct tacaactgct ctagattagt agatgcatct   2520

aagcaggcag caggaacttt aaatttttta agttcatgtc tatgacatga acaatgtgtg   2580

ggataatgtc attaatatat cctaaattaa cctaaacgta tttcactaac tctggctcct   2640

tctccataaa gcacatttta aggaacaaga attgctaaat ataaaaacat aaataatacc   2700

ataatacatg gctatcatca aaagtgtata gaatattata gtttaaaagt atttagttga   2760

ttacttttca gttttgtttt gttttttgag acggagtctc actctgttgc ccaggctgga   2820

gtgcagtggc accatctcag ttcactgcaa cttctgcctc ccgagttcaa gcgattctcc   2880

tgcctcagcc tcccgagtag ctggaattat aggcgtgcac caccacgccc agctaatttt   2940

tgtattttta gtaaagacag ggttttgcca cattagccag gctggtctca aactcctgac   3000

ctcaggtgat ccacccaccc cagcctccca aagtgctaag attacaggcg tgagccactg   3060

agcccagcct acttttcagt ttttaacata atttttgttt tatccacaac ttttcaagta   3120

ttgaaagtag aataaaaaca tgggttctta gtctttagct atctgttaaa gcctatgaat   3180

gccttcttaa aatcatgttt ttaaatgcat aaaatatata ggattacaaa ggaatctaat   3240

tatatcgaaa tacagttatt aaaatgttaa aagataagtt tgttatatat taatatgcat   3300

gcttctttat aaatgcatta aataagagtt aatagctatc ctaaatttga aatagtgata   3360

agcataatga aaatagatgc aaaaaactaa tgtgatatga aaatatctgg gtttttcttt   3420

tgatgatgaa gtattgctaa tattaccgtg gtttatgaac tatgttcaga attgaagaaa   3480

atcctaactt tcagttagag gttagtgacg gggttcagga caccctacac aaaatacagc   3540

actttgacat attgaatatt ttaagctgaa ggcatttgag gaaattgcag aagcaggaag   3600

gtgactctga ccttctgcct gctgttctcc ccagaagcag ccataaaacc tgggaaggat   3660

tttctgacct tcccctgaag tagatcataa gactgtcatg taagaggtgc tctcctggca   3720

cccagagaaa aggagcatcc ttacctccaa aagcacaggg acacaaagag gaatctaaac   3780

aaacaggcct ctcagtttcc cccagtttat tacatttagc ttgttcacac tttgccctat   3840

gacatttcta catcactggc tgctcttcat caaacctact ataaaaaaca ttcaagttca   3900

actgtttctt tgggccttta tttccttatg gagcccctcg tgtcgtgtaa aacttatatt   3960

aaataaatgt gcatgctttt ctcttgctaa tctctctttt gttatagaga tctcagccct   4020

aaacctagga tggatagaag gaaacatatg ttctccccta cattagtaaa aataaaaatg   4080

gaatttttta cccatacaaa                                               4100


<210>  634
<211>  331
<212>  PRT
<213>  Homosapiens

<400>  634

Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                85                  90                  95      


Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
            100                 105                 110         


Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
        115                 120                 125             


Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
    130                 135                 140                 


Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
145                 150                 155                 160 


Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
                165                 170                 175     


Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
            180                 185                 190         


Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
        195                 200                 205             


Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
    210                 215                 220                 


Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
225                 230                 235                 240 


Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                245                 250                 255     


Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
            260                 265                 270         


Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
    290                 295                 300                 


Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
305                 310                 315                 320 


Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                325                 330     


<210>  635
<211>  1702
<212>  DNA
<213>  Homosapiens

<400>  635
aaattttcca gccgatcact ggagctgact tccgcaatcc cgatggaata aatctagcac     60

ccctgatggt gtgcccacac tttgctgccg aaacgaagcc agacaacaga tttccatcag    120

caggatgtgg gggctcaagg ttctgctgct acctgtggtg agctttgctc tgtaccctga    180

ggagatactg gacacccact gggagctatg gaagaagacc cacaggaagc aatataacaa    240

caaggtggat gaaatctctc ggcgtttaat ttgggaaaaa aacctgaagt atatttccat    300

ccataacctt gaggcttctc ttggtgtcca tacatatgaa ctggctatga accacctggg    360

ggacatgacc agtgaagagg tggttcagaa gatgactgga ctcaaagtac ccctgtctca    420

ttcccgcagt aatgacaccc tttatatccc agaatgggaa ggtagagccc cagactctgt    480

cgactatcga aagaaaggat atgttactcc tgtcaaaaat cagggtcagt gtggttcctg    540

ttgggctttt agctctgtgg gtgccctgga gggccaactc aagaagaaaa ctggcaaact    600

cttaaatctg agtccccaga acctagtgga ttgtgtgtct gagaatgatg gctgtggagg    660

gggctacatg accaatgcct tccaatatgt gcagaagaac cggggtattg actctgaaga    720

tgcctaccca tatgtgggac aggaagagag ttgtatgtac aacccaacag gcaaggcagc    780

taaatgcaga gggtacagag agatccccga ggggaatgag aaagccctga agagggcagt    840

ggcccgagtg ggacctgtct ctgtggccat tgatgcaagc ctgacctcct tccagtttta    900

cagcaaaggt gtgtattatg atgaaagctg caatagcgat aatctgaacc atgcggtttt    960

ggcagtggga tatggaatcc agaagggaaa caagcactgg ataattaaaa acagctgggg   1020

agaaaactgg ggaaacaaag gatatatcct catggctcga aataagaaca acgcctgtgg   1080

cattgccaac ctggccagct tccccaagat gtgactccag ccagccaaat ccatcctgct   1140

cttccatttc ttccacgatg gtgcagtgta acgatgcact ttggaaggga gttggtgtgc   1200

tatttttgaa gcagatgtgg tgatactgag attgtctgtt cagtttcccc atttgtttgt   1260

gcttcaaatg atccttccta ctttgcttct ctccacccat gacctttttc actgtggcca   1320

tcaggacttt ccctgacagc tgtgtactct taggctaaga gatgtgacta cagcctgccc   1380

ctgactgtgt tgtcccaggg ctgatgctgt acaggtacag gctggagatt ttcacatagg   1440

ttagattctc attcacggga ctagttagct ttaagcaccc tagaggacta gggtaatctg   1500

acttctcact tcctaagttc ccttctatat cctcaaggta gaaatgtcta tgttttctac   1560

tccaattcat aaatctattc ataagtcttt ggtacaagtt tacatgataa aaagaaatgt   1620

gatttgtctt cccttctttg cacttttgaa ataaagtatt tatctcctgt ctacagttta   1680

ataaatagca tctagtacac at                                            1702


<210>  636
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  636

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  637
<211>  4846
<212>  DNA
<213>  Homosapiens

<400>  637
atcttggatt ccgcggtagc ggaggcggcg gtcaggcgcc gcttctgggg agtggccttt     60

cttttcccct ccctcccggt tcggtggcgg cggctcctcc cactgggggg gggggtggcg    120

cggcggcggt ggcatctgcg gccatggcgg cgactactgc caaccccgaa atgacatcag    180

atgtaccatc actgggtcca gccattgcct ctggaaactc tggacctgga attcaaggtg    240

gaggagccat tgtccagagg gctattaagc ggcgaccagg gctggatttt gatgatgatg    300

gagaagggaa cagtaaattt ttgaggtgtg atgatgatca gatgtctaac gataaggagc    360

ggtttgccag gtcggatgat gagcagagct ctgcggataa agagagactt gccagggaaa    420

atcacagtga aattgaacgg cggcgacgga acaagatgac agcctacatc acagaactgt    480

cagatatggt acccacctgt agtgccctgg ctcgaaaacc agacaagcta accatcttac    540

gcatggcagt ttctcacatg aagtccttgc ggggaactgg caacacatcc actgatggct    600

cctataagcc gtctttcctc actgatcagg aactgaaaca tttgatcttg gaggcagcag    660

atggctttct gtttattgtc tcatgtgaga caggcagggt ggtgtatgtg tctgactccg    720

tgactcctgt tttgaaccag ccacagtctg aatggtttgg cagcacactc tatgatcagg    780

tgcacccaga tgatgtggat aaacttcgtg agcagctttc cacttcagaa aatgccctga    840

cagggcgtat cctggatcta aagactggaa cagtgaaaaa ggaaggtcag cagtcttcca    900

tgagaatgtg tatgggctca aggagatcgt ttatttgccg aatgaggtgt ggcagtagct    960

ctgtggaccc agtttctgtg aataggctga gctttgtgag gaacagatgc aggaatggac   1020

ttggctctgt aaaggatggg gaacctcact tcgtggtggt ccactgcaca ggctacatca   1080

aggcctggcc cccagcaggt gtttccctcc cagatgatga cccagaggct ggccagggaa   1140

gcaagttttg cctagtggcc attggcagat tgcaggtaac tagttctccc aactgtacag   1200

acatgagtaa tgtttgtcaa ccaacagagt tcatctcccg acacaacatt gagggtatct   1260

tcacttttgt ggatcaccgc tgtgtggcta ctgttggcta ccagccacag gaactcttag   1320

gaaagaatat tgtagaattc tgtcatcctg aagaccagca gcttctaaga gacagcttcc   1380

aacaggtagt gaaattaaaa ggccaagtgc tgtctgtcat gttccggttc cggtctaaga   1440

accaagaatg gctctggatg agaaccagct cctttacttt ccagaaccct tactcagatg   1500

aaattgagta catcatctgt accaacacca atgtgaagaa ctctagccaa gaaccacggc   1560

ctacactctc caacacaatc cagaggccac aactaggtcc cacagctaat ttacccctgg   1620

agatgggctc aggacagctg gcacccaggc agcagcaaca gcaaacagaa ttggacatgg   1680

taccaggaag agatggactg gccagctaca atcattccca ggtggttcag cctgtgacaa   1740

ccacaggacc agaacacagc aagccccttg agaagtcaga tggtttattt gcccaggata   1800

gagatccaag attttcagaa atctatcaca acatcaatgc ggatcagagt aaaggcatct   1860

cctccagcac tgtccctgcc acccaacagc tattctccca gggcaacaca ttccctccta   1920

ccccccggcc ggcagagaat ttcaggaata gtggcctagc ccctcctgta accattgtcc   1980

agccatcagc ttctgcagga cagatgttgg cccagatttc ccgccactcc aaccccaccc   2040

aaggagcaac cccaacttgg acccctacta cccgctcagg cttttctgcc cagcaggtgg   2100

ctacccaggc tactgctaag actcgtactt cccagtttgg tgtgggcagc tttcagactc   2160

catcctcctt cagctccatg tccctccctg gtgccccaac tgcatcgcct ggtgctgctg   2220

cctaccctag tctcaccaat cgtggatcta actttgctcc tgagactgga cagactgcag   2280

gacaattcca gacacggaca gcagagggtg tgggtgtctg gccacagtgg cagggccagc   2340

agcctcatca tcgttcaagt tctagtgagc aacatgttca acaaccgcca gcacagcaac   2400

ctggccagcc tgaggtcttc caggagatgc tgtccatgct gggagatcag agcaacagct   2460

acaacaatga agaattccct gatctaacta tgtttccccc cttttcagaa tagaactatt   2520

ggggtgagga taaggggtgg gggagaaaaa atcactgttt gtttttaaaa agcaaatctt   2580

tctgtaaaca gaataaaagt tcctctccct tcccttccct cacccctgac atgtaccccc   2640

tttcccttct ggctgttccc ctgctctgtt gcctctctaa ggtaacattt atagaagaaa   2700

tggaatgaat ctccaaggct tttaggactg tctgaaaatt tgaggctggg tgaagttaaa   2760

acacctttcc ttatgtctcc tgacctgaaa ttgtatagtg ttgatttgtg ctgagatcaa   2820

gaggcaggtt agaagaacct gacatccact gtttgccttg gatagtatgg cttgtttttg   2880

gaaagaaatt ctgaagagag tggaggagag gagaaatgtc ctcatatttg aggaccatga   2940

aacattgtag gtatatatgg ggctttagca agtttgagca taggctcttt ttgctgcctg   3000

tgagcagtcc ctctggaaag aaacatgtga gtaagtgaga gagagtgtgt gtgtatgtgt   3060

gtgtgtgtgt gtgtgcgcac acatgcttct gtatttcact ctttctccct attagggagt   3120

tatgcaaaat ttgtccccga ttttaccttt gtctttctgt gtacttttca aagagtccta   3180

aggagttaaa tcttccaggt attttccact tagtattgca gccaaagaat atttaaataa   3240

acgtctttgc tgcgcttgca tccatgccca gccaatatac aactgtaaag caaatataga   3300

aagtcggctg ttgatacgat tgtctgttat cgaacacatt cagtgataaa gctgggttac   3360

tgctgctttt ggtgctctca ccttatctgg aagatctgca aacattacct aaataggctg   3420

gcaagataaa cactttctgg aacccgagac ttggccataa agataatgct gcatttttct   3480

gtcagaatca catatgatgt gtgttctgta gaggttattt ctgcatggaa actcaacttc   3540

ttggattagc cgtcccagtg aaaatcctca ttgttggagt gtaaaccaaa tacgaagccc   3600

tcttgcaaag tagcctcttt catcccatac tcaaaatacc cagtttagca agcaactgag   3660

atttaagtct ctctggccct aagaggtttt tcctctttgc tccctccaat cttgagattg   3720

ggttttgctt tagagtgcaa gtatcataat tccgtatgat agatggggcc tggacaccca   3780

tctcaacagg gtcacttggt aattaacaat agccatataa atgcggatac aggttactac   3840

cctcaccctt taccttcctc aggtaacagt cgtagatacc agcttttttt tttttttttt   3900

taaattggct ttggccagta gctaaagtgc aagactgaat taatgagaag atatattaaa   3960

tgtagtcata ggggactgag gagcaagggt ggccttgaag aggccaaagg aatgtccatt   4020

tgctgagttt cccttcctta tgtctccagt ctggtgccag gtagtggagt aaaaaaggag   4080

acagtttatt tttttattct atgtgcacac ttacagtata catatatatt tatatcacaa   4140

tttacgaaac caaaaagttg agtttccaat ggaacccttg ttttttaata atcgactttt   4200

taaatgtgat caggactata atattgtaca gttattatag ggcttttggg gaaggggagg   4260

atagcgagaa gatgctctgg gggttttgtt tttgcttttc cttcagggtt ttatttttga   4320

ctgttttgtt ttcttgttgg ccatttctgt attgctggca tctgtgctaa gctttacagt   4380

ggcaaaaata atgacatgta gcaaagattt tcaaacaaaa tattttttcc ttttgtaaaa   4440

tttcttgtgt tgtgtgatct tgattgcggc tttatcattc ctttccagtt cataaacaac   4500

aggcacccac aaccagagga atctatagtt taagctccag acatacaaac ataaggcaca   4560

ttgtgtcttt aatttcagga atcagaaatc atagggttct gatcacattg cacgcctccc   4620

ccctcacttg tcctcctgat cctgacacat tctgagtaac atcagcagga atgctctgac   4680

catgaggtgg gggttttggg gtgggcgttg cctgggttct tgggagagag gggaagagtc   4740

gggacttgaa aaccactagg gcacatctgg atgccttccc ccagtatgtc cttttctgga   4800

ttaaaatgag tgaaatttaa actgaaaaaa aaaaaaaaaa aaaaaa                  4846


<210>  638
<211>  789
<212>  PRT
<213>  Homosapiens

<400>  638

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                405                 410                 415     


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
            420                 425                 430         


Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
        435                 440                 445             


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val 
    450                 455                 460                 


Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
465                 470                 475                 480 


Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser 
                485                 490                 495     


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met 
            500                 505                 510         


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
        515                 520                 525             


Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
    530                 535                 540                 


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
545                 550                 555                 560 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr 
                565                 570                 575     


Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro 
            580                 585                 590         


Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
        595                 600                 605             


Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
    610                 615                 620                 


Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr 
625                 630                 635                 640 


Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln Ala 
                645                 650                 655     


Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr 
            660                 665                 670         


Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser 
        675                 680                 685             


Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe 
    690                 695                 700                 


Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala 
705                 710                 715                 720 


Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His 
                725                 730                 735     


Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln 
            740                 745                 750         


Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp 
        755                 760                 765             


Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe 
    770                 775                 780                 


Pro Pro Phe Ser Glu 
785                 


<210>  639
<211>  4801
<212>  DNA
<213>  Homosapiens

<400>  639
atcttggatt ccgcggtagc ggaggcggcg gtcaggcgcc gcttctgggg agtggccttt     60

cttttcccct ccctcccggt tcggtggcgg cggctcctcc cactgggggg gggggtggcg    120

cggcggcggt ggcatctgcg gccatggcgg cgactactgc caaccccgaa atgacatcag    180

atgtaccatc actgggtcca gccattgcct ctggaaactc tggacctgga attcaaggtg    240

gaggagccat tgtccagagg gctattaagc ggcgaccagg gctggatttt gatgatgatg    300

gagaagggaa cagtaaattt ttgaggtgtg atgatgatca gatgtctaac gataaggagc    360

ggtttgccag ggaaaatcac agtgaaattg aacggcggcg acggaacaag atgacagcct    420

acatcacaga actgtcagat atggtaccca cctgtagtgc cctggctcga aaaccagaca    480

agctaaccat cttacgcatg gcagtttctc acatgaagtc cttgcgggga actggcaaca    540

catccactga tggctcctat aagccgtctt tcctcactga tcaggaactg aaacatttga    600

tcttggaggc agcagatggc tttctgttta ttgtctcatg tgagacaggc agggtggtgt    660

atgtgtctga ctccgtgact cctgttttga accagccaca gtctgaatgg tttggcagca    720

cactctatga tcaggtgcac ccagatgatg tggataaact tcgtgagcag ctttccactt    780

cagaaaatgc cctgacaggg cgtatcctgg atctaaagac tggaacagtg aaaaaggaag    840

gtcagcagtc ttccatgaga atgtgtatgg gctcaaggag atcgtttatt tgccgaatga    900

ggtgtggcag tagctctgtg gacccagttt ctgtgaatag gctgagcttt gtgaggaaca    960

gatgcaggaa tggacttggc tctgtaaagg atggggaacc tcacttcgtg gtggtccact   1020

gcacaggcta catcaaggcc tggcccccag caggtgtttc cctcccagat gatgacccag   1080

aggctggcca gggaagcaag ttttgcctag tggccattgg cagattgcag gtaactagtt   1140

ctcccaactg tacagacatg agtaatgttt gtcaaccaac agagttcatc tcccgacaca   1200

acattgaggg tatcttcact tttgtggatc accgctgtgt ggctactgtt ggctaccagc   1260

cacaggaact cttaggaaag aatattgtag aattctgtca tcctgaagac cagcagcttc   1320

taagagacag cttccaacag gtagtgaaat taaaaggcca agtgctgtct gtcatgttcc   1380

ggttccggtc taagaaccaa gaatggctct ggatgagaac cagctccttt actttccaga   1440

acccttactc agatgaaatt gagtacatca tctgtaccaa caccaatgtg aagaactcta   1500

gccaagaacc acggcctaca ctctccaaca caatccagag gccacaacta ggtcccacag   1560

ctaatttacc cctggagatg ggctcaggac agctggcacc caggcagcag caacagcaaa   1620

cagaattgga catggtacca ggaagagatg gactggccag ctacaatcat tcccaggtgg   1680

ttcagcctgt gacaaccaca ggaccagaac acagcaagcc ccttgagaag tcagatggtt   1740

tatttgccca ggatagagat ccaagatttt cagaaatcta tcacaacatc aatgcggatc   1800

agagtaaagg catctcctcc agcactgtcc ctgccaccca acagctattc tcccagggca   1860

acacattccc tcctaccccc cggccggcag agaatttcag gaatagtggc ctagcccctc   1920

ctgtaaccat tgtccagcca tcagcttctg caggacagat gttggcccag atttcccgcc   1980

actccaaccc cacccaagga gcaaccccaa cttggacccc tactacccgc tcaggctttt   2040

ctgcccagca ggtggctacc caggctactg ctaagactcg tacttcccag tttggtgtgg   2100

gcagctttca gactccatcc tccttcagct ccatgtccct ccctggtgcc ccaactgcat   2160

cgcctggtgc tgctgcctac cctagtctca ccaatcgtgg atctaacttt gctcctgaga   2220

ctggacagac tgcaggacaa ttccagacac ggacagcaga gggtgtgggt gtctggccac   2280

agtggcaggg ccagcagcct catcatcgtt caagttctag tgagcaacat gttcaacaac   2340

cgccagcaca gcaacctggc cagcctgagg tcttccagga gatgctgtcc atgctgggag   2400

atcagagcaa cagctacaac aatgaagaat tccctgatct aactatgttt cccccctttt   2460

cagaatagaa ctattggggt gaggataagg ggtgggggag aaaaaatcac tgtttgtttt   2520

taaaaagcaa atctttctgt aaacagaata aaagttcctc tcccttccct tccctcaccc   2580

ctgacatgta ccccctttcc cttctggctg ttcccctgct ctgttgcctc tctaaggtaa   2640

catttataga agaaatggaa tgaatctcca aggcttttag gactgtctga aaatttgagg   2700

ctgggtgaag ttaaaacacc tttccttatg tctcctgacc tgaaattgta tagtgttgat   2760

ttgtgctgag atcaagaggc aggttagaag aacctgacat ccactgtttg ccttggatag   2820

tatggcttgt ttttggaaag aaattctgaa gagagtggag gagaggagaa atgtcctcat   2880

atttgaggac catgaaacat tgtaggtata tatggggctt tagcaagttt gagcataggc   2940

tctttttgct gcctgtgagc agtccctctg gaaagaaaca tgtgagtaag tgagagagag   3000

tgtgtgtgta tgtgtgtgtg tgtgtgtgtg cgcacacatg cttctgtatt tcactctttc   3060

tccctattag ggagttatgc aaaatttgtc cccgatttta cctttgtctt tctgtgtact   3120

tttcaaagag tcctaaggag ttaaatcttc caggtatttt ccacttagta ttgcagccaa   3180

agaatattta aataaacgtc tttgctgcgc ttgcatccat gcccagccaa tatacaactg   3240

taaagcaaat atagaaagtc ggctgttgat acgattgtct gttatcgaac acattcagtg   3300

ataaagctgg gttactgctg cttttggtgc tctcacctta tctggaagat ctgcaaacat   3360

tacctaaata ggctggcaag ataaacactt tctggaaccc gagacttggc cataaagata   3420

atgctgcatt tttctgtcag aatcacatat gatgtgtgtt ctgtagaggt tatttctgca   3480

tggaaactca acttcttgga ttagccgtcc cagtgaaaat cctcattgtt ggagtgtaaa   3540

ccaaatacga agccctcttg caaagtagcc tctttcatcc catactcaaa atacccagtt   3600

tagcaagcaa ctgagattta agtctctctg gccctaagag gtttttcctc tttgctccct   3660

ccaatcttga gattgggttt tgctttagag tgcaagtatc ataattccgt atgatagatg   3720

gggcctggac acccatctca acagggtcac ttggtaatta acaatagcca tataaatgcg   3780

gatacaggtt actaccctca ccctttacct tcctcaggta acagtcgtag ataccagctt   3840

tttttttttt ttttttaaat tggctttggc cagtagctaa agtgcaagac tgaattaatg   3900

agaagatata ttaaatgtag tcatagggga ctgaggagca agggtggcct tgaagaggcc   3960

aaaggaatgt ccatttgctg agtttccctt ccttatgtct ccagtctggt gccaggtagt   4020

ggagtaaaaa aggagacagt ttattttttt attctatgtg cacacttaca gtatacatat   4080

atatttatat cacaatttac gaaaccaaaa agttgagttt ccaatggaac ccttgttttt   4140

taataatcga ctttttaaat gtgatcagga ctataatatt gtacagttat tatagggctt   4200

ttggggaagg ggaggatagc gagaagatgc tctgggggtt ttgtttttgc ttttccttca   4260

gggttttatt tttgactgtt ttgttttctt gttggccatt tctgtattgc tggcatctgt   4320

gctaagcttt acagtggcaa aaataatgac atgtagcaaa gattttcaaa caaaatattt   4380

tttccttttg taaaatttct tgtgttgtgt gatcttgatt gcggctttat cattcctttc   4440

cagttcataa acaacaggca cccacaacca gaggaatcta tagtttaagc tccagacata   4500

caaacataag gcacattgtg tctttaattt caggaatcag aaatcatagg gttctgatca   4560

cattgcacgc ctcccccctc acttgtcctc ctgatcctga cacattctga gtaacatcag   4620

caggaatgct ctgaccatga ggtgggggtt ttggggtggg cgttgcctgg gttcttggga   4680

gagaggggaa gagtcgggac ttgaaaacca ctagggcaca tctggatgcc ttcccccagt   4740

atgtcctttt ctggattaaa atgagtgaaa tttaaactga aaaaaaaaaa aaaaaaaaaa   4800

a                                                                   4801


<210>  640
<211>  774
<212>  PRT
<213>  Homosapiens

<400>  640

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Glu Asn His Ser 
65                  70                  75                  80  


Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu 
                85                  90                  95      


Leu Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp 
            100                 105                 110         


Lys Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg 
        115                 120                 125             


Gly Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu 
    130                 135                 140                 


Thr Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe 
145                 150                 155                 160 


Leu Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp 
                165                 170                 175     


Ser Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser 
            180                 185                 190         


Thr Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu 
        195                 200                 205             


Gln Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu 
    210                 215                 220                 


Lys Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met 
225                 230                 235                 240 


Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser 
                245                 250                 255     


Ser Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn 
            260                 265                 270         


Arg Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe 
        275                 280                 285             


Val Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly 
    290                 295                 300                 


Val Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe 
305                 310                 315                 320 


Cys Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys 
                325                 330                 335     


Thr Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His 
            340                 345                 350         


Asn Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr 
        355                 360                 365             


Val Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe 
    370                 375                 380                 


Cys His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val 
385                 390                 395                 400 


Val Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser 
                405                 410                 415     


Lys Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln 
            420                 425                 430         


Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn 
        435                 440                 445             


Val Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile 
    450                 455                 460                 


Gln Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly 
465                 470                 475                 480 


Ser Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp 
                485                 490                 495     


Met Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val 
            500                 505                 510         


Val Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu 
        515                 520                 525             


Lys Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu 
    530                 535                 540                 


Ile Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser 
545                 550                 555                 560 


Thr Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro 
                565                 570                 575     


Pro Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro 
            580                 585                 590         


Pro Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala 
        595                 600                 605             


Gln Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp 
    610                 615                 620                 


Thr Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln 
625                 630                 635                 640 


Ala Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln 
                645                 650                 655     


Thr Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala 
            660                 665                 670         


Ser Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn 
        675                 680                 685             


Phe Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr 
    690                 695                 700                 


Ala Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His 
705                 710                 715                 720 


His Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln 
                725                 730                 735     


Gln Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly 
            740                 745                 750         


Asp Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met 
        755                 760                 765             


Phe Pro Pro Phe Ser Glu 
    770                 


<210>  641
<211>  3563
<212>  DNA
<213>  Homosapiens

<400>  641
atcttggatt ccgcggtagc ggaggcggcg gtcaggcgcc gcttctgggg agtggccttt     60

cttttcccct ccctcccggt tcggtggcgg cggctcctcc cactgggggg gggggtggcg    120

cggcggcggt ggcatctgcg gccatggcgg cgactactgc caaccccgaa atgacatcag    180

atgtaccatc actgggtcca gccattgcct ctggaaactc tggacctgga attcaaggtg    240

gaggagccat tgtccagagg gctattaagc ggcgaccagg gctggatttt gatgatgatg    300

gagaagggaa cagtaaattt ttgaggtgtg atgatgatca gatgtctaac gataaggagc    360

ggtttgccag gtcggatgat gagcagagct ctgcggataa agagagactt gccagggaaa    420

atcacagtga aattgaacgg cggcgacgga acaagatgac agcctacatc acagaactgt    480

cagatatggt acccacctgt agtgccctgg ctcgaaaacc agacaagcta accatcttac    540

gcatggcagt ttctcacatg aagtccttgc ggggaactgg caacacatcc actgatggct    600

cctataagcc gtctttcctc actgatcagg aactgaaaca tttgatcttg gaggcagcag    660

atggctttct gtttattgtc tcatgtgaga caggcagggt ggtgtatgtg tctgactccg    720

tgactcctgt tttgaaccag ccacagtctg aatggtttgg cagcacactc tatgatcagg    780

tgcacccaga tgatgtggat aaacttcgtg agcagctttc cacttcagaa aatgccctga    840

cagggcgtat cctggatcta aagactggaa cagtgaaaaa ggaaggtcag cagtcttcca    900

tgagaatgtg tatgggctca aggagatcgt ttatttgccg aatgaggtgt ggcagtagct    960

ctgtggaccc agtttctgtg aataggctga gctttgtgag gaacagatgc aggaatggac   1020

ttggctctgt aaaggatggg gaacctcact tcgtggtggt ccactgcaca ggctacatca   1080

aggcctggcc cccagcaggt gtttccctcc cagatgatga cccagcctga ggtcttccag   1140

gagatgctgt ccatgctggg agatcagagc aacagctaca acaatgaaga attccctgat   1200

ctaactatgt ttcccccctt ttcagaatag aactattggg gtgaggataa ggggtggggg   1260

agaaaaaatc actgtttgtt tttaaaaagc aaatctttct gtaaacagaa taaaagttcc   1320

tctcccttcc cttccctcac ccctgacatg tacccccttt cccttctggc tgttcccctg   1380

ctctgttgcc tctctaaggt aacatttata gaagaaatgg aatgaatctc caaggctttt   1440

aggactgtct gaaaatttga ggctgggtga agttaaaaca cctttcctta tgtctcctga   1500

cctgaaattg tatagtgttg atttgtgctg agatcaagag gcaggttaga agaacctgac   1560

atccactgtt tgccttggat agtatggctt gtttttggaa agaaattctg aagagagtgg   1620

aggagaggag aaatgtcctc atatttgagg accatgaaac attgtaggta tatatggggc   1680

tttagcaagt ttgagcatag gctctttttg ctgcctgtga gcagtccctc tggaaagaaa   1740

catgtgagta agtgagagag agtgtgtgtg tatgtgtgtg tgtgtgtgtg tgcgcacaca   1800

tgcttctgta tttcactctt tctccctatt agggagttat gcaaaatttg tccccgattt   1860

tacctttgtc tttctgtgta cttttcaaag agtcctaagg agttaaatct tccaggtatt   1920

ttccacttag tattgcagcc aaagaatatt taaataaacg tctttgctgc gcttgcatcc   1980

atgcccagcc aatatacaac tgtaaagcaa atatagaaag tcggctgttg atacgattgt   2040

ctgttatcga acacattcag tgataaagct gggttactgc tgcttttggt gctctcacct   2100

tatctggaag atctgcaaac attacctaaa taggctggca agataaacac tttctggaac   2160

ccgagacttg gccataaaga taatgctgca tttttctgtc agaatcacat atgatgtgtg   2220

ttctgtagag gttatttctg catggaaact caacttcttg gattagccgt cccagtgaaa   2280

atcctcattg ttggagtgta aaccaaatac gaagccctct tgcaaagtag cctctttcat   2340

cccatactca aaatacccag tttagcaagc aactgagatt taagtctctc tggccctaag   2400

aggtttttcc tctttgctcc ctccaatctt gagattgggt tttgctttag agtgcaagta   2460

tcataattcc gtatgataga tggggcctgg acacccatct caacagggtc acttggtaat   2520

taacaatagc catataaatg cggatacagg ttactaccct caccctttac cttcctcagg   2580

taacagtcgt agataccagc tttttttttt ttttttttaa attggctttg gccagtagct   2640

aaagtgcaag actgaattaa tgagaagata tattaaatgt agtcataggg gactgaggag   2700

caagggtggc cttgaagagg ccaaaggaat gtccatttgc tgagtttccc ttccttatgt   2760

ctccagtctg gtgccaggta gtggagtaaa aaaggagaca gtttattttt ttattctatg   2820

tgcacactta cagtatacat atatatttat atcacaattt acgaaaccaa aaagttgagt   2880

ttccaatgga acccttgttt tttaataatc gactttttaa atgtgatcag gactataata   2940

ttgtacagtt attatagggc ttttggggaa ggggaggata gcgagaagat gctctggggg   3000

ttttgttttt gcttttcctt cagggtttta tttttgactg ttttgttttc ttgttggcca   3060

tttctgtatt gctggcatct gtgctaagct ttacagtggc aaaaataatg acatgtagca   3120

aagattttca aacaaaatat tttttccttt tgtaaaattt cttgtgttgt gtgatcttga   3180

ttgcggcttt atcattcctt tccagttcat aaacaacagg cacccacaac cagaggaatc   3240

tatagtttaa gctccagaca tacaaacata aggcacattg tgtctttaat ttcaggaatc   3300

agaaatcata gggttctgat cacattgcac gcctcccccc tcacttgtcc tcctgatcct   3360

gacacattct gagtaacatc agcaggaatg ctctgaccat gaggtggggg ttttggggtg   3420

ggcgttgcct gggttcttgg gagagagggg aagagtcggg acttgaaaac cactagggca   3480

catctggatg ccttccccca gtatgtcctt ttctggatta aaatgagtga aatttaaact   3540

gaaaaaaaaa aaaaaaaaaa aaa                                           3563


<210>  642
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  642

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Ala 
                325             


<210>  643
<211>  4420
<212>  DNA
<213>  Homosapiens

<400>  643
ctcccttatc ccttcgcttt cgctcttttc cgtcgaggcc gacccctgag ttgtgagtct     60

ggggtctggt tggtgaaaaa gagcccttga agctggaaga cgggagagga caaaagcatg    120

tcttcccttc ctgggtgcat tggtttggat gcagcaacag ctacagtgga gtctgaagag    180

attgcagagc tgcaacaggc agtggttgag gaactgggta tctctatgga ggaacttcgg    240

catttcatcg atgaggaact ggagaagatg gattgtgtac agcaacgcaa gaagcagcta    300

gcagagttag agacatgggt aatacagaaa gaatctgagg tggctcacgt tgaccaactc    360

tttgatgatg catccagggc agtgactaat tgtgagtctt tggtgaagga cttctactcc    420

aagctgggac tacaataccg ggacagtagc tctgaggacg aatcttcccg gcctacagaa    480

ataattgaga ttcctgatga agatgatgat gtcctcagta ttgattcagg tgatgctggg    540

agcagaactc caaaagacca gaagctccgt gaagctatgg ctgccttaag aaagtcagct    600

caagatgttc agaagttcat ggatgctgtc aacaagaaga gcagttccca ggatctgcat    660

aaaggaacct tgagtcagat gtctggagaa ctaagcaaag atggtgacct gatagtcagc    720

atgcgaattc tgggcaagaa gagaactaag acttggcaca aaggcaccct tattgccatc    780

cagacagttg ggccagggaa gaaatacaag gtgaaatttg acaacaaagg aaagagtcta    840

ctgtcgggga accatattgc ctatgattac caccctcctg ctgacaagct gtatgtgggc    900

agtcgggtgg tcgccaaata caaagatggg aatcaggtct ggctctatgc tggcattgta    960

gctgagacac caaacgtcaa aaacaagctc aggtttctca ttttctttga tgatggctat   1020

gcttcctatg tcacacagtc ggaactgtat cccatttgcc ggccactgaa aaagacttgg   1080

gaggacatag aagacatctc ctgccgtgac ttcatagagg agtatgtcac tgcctacccc   1140

aaccgcccca tggtactgct caagagtggc cagcttatca agactgagtg ggaaggcacg   1200

tggtggaagt cccgagttga ggaggtggat ggcagcctag tcaggatcct cttcctggat   1260

gacaaaagat gtgagtggat ctatcgaggc tctacacggc tggagcccat gttcagcatg   1320

aaaacatcct cagcctctgc actggagaag aagcaaggac agctcaggac acgtccaaat   1380

atgggtgctg tgaggagcaa aggccctgtt gtccagtaca cacaggatct gaccggtact   1440

ggaacccagt tcaagccagt ggaaccccca cagcctacag ctccacctgc cccacctttc   1500

ccacctgctc cacctctatc cccccaagca ggtgacagtg acttggaaag ccagcttgcc   1560

cagtcacgga agcaggtagc caaaaagagc acgtcctttc gaccaggatc tgtgggctct   1620

ggtcattcct cctctacatc tcctgcactc agtgaaaatg tctctggtgg gaaacctggg   1680

atcaaccaga catatagatc acctttaggc tccacagcct ctgccccagc accctcagca   1740

ctcccggccc ctccagcacc cccagtcttc catggcatgc tggagcgggc cccagcagag   1800

ccctcctacc gtgctcccat ggagaagctt ttctacttac ctcatgtctg cagctatacc   1860

tgcctgtctc gagtcagacc tatgaggaat gagcagtacc ggggcaagaa ccctctgctg   1920

gtcccgttac tatatgactt ccggcggatg acagcccggc gtcgagttaa ccgcaagatg   1980

ggctttcatg ttatctataa gacaccttgt ggtctctgcc ttcggacaat gcaggagata   2040

gaacgctacc ttttcgagac tggctgtgac ttcctcttcc tggagatgtt ctgtttggat   2100

ccatatgttc ttgtggaccg aaagtttcag ccctataagc ctttttacta tattttggac   2160

atcacttatg ggaaggaaga tgttccccta tcctgtgtca atgagattga cacaacccct   2220

ccaccccagg tggcctacag caaggaacgt atcccgggca agggtgtttt cattaacaca   2280

ggccctgaat ttctggttgg ctgtgactgc aaggatgggt gtcgggacaa gtccaagtgt   2340

gcctgccatc aactaactat ccaggctaca gcctgtaccc caggaggcca aatcaaccct   2400

aactctggct accagtacaa gagactagaa gagtgtctac ccacaggggt atatgagtgt   2460

aacaaacgct gcaaatgtga cccaaacatg tgcacaaacc ggttggtgca acatggacta   2520

caagttcggc tacagctatt caagacacag aacaagggct ggggtatccg ctgcttggat   2580

gacattgcca aaggctcttt tgtttgtatt tatgcaggca aaatcctgac agatgacttt   2640

gcagacaagg agggtctgga aatgggtgat gagtactttg caaatctgga ccatatcgag   2700

agcgtggaga acttcaaaga aggatatgag agtgatgccc cctgttcctc tgacagcagt   2760

ggtgtagact tgaaggacca ggaagatggc aacagcggta cagaggaccc tgaagagtcc   2820

aatgatgata gctcagatga taacttctgt aaggatgagg acttcagcac cagttcagtg   2880

tggcggagct atgctacccg gaggcagacc cggggccaga aagagaacgg actctctgag   2940

acaacttcca aggactccca ccccccagat cttggacccc cacatattcc tgttcctccc   3000

tcaatccctg taggtggctg caatccacct tcctccgaag agacacccaa gaacaaggtg   3060

gcctcatggt tgagctgcaa tagtgtcagt gaaggtggtt ttgctgactc tgatagccat   3120

tcatccttca agactaatga aggtggggag ggccgggctg ggggaagccg aatggaggct   3180

gagaaggcct ccacctcagg actaggcatc aaggatgagg gagacatcaa acaggccaag   3240

aaagaggaca ctgacgaccg aaacaagatg tcagtagtta ctgaaagctc tcgaaattac   3300

ggttacaatc cttctcctgt gaagcctgaa ggacttcgcc gcccacctag taagactagt   3360

atgcatcaaa gccgaagact catggcttct gctcagtcca accctgatga tgtcctgaca   3420

ctgtccagca gcacagaaag tgagggggaa agtgggacca gccgaaagcc cactgctggt   3480

cagacttcgg ctacagcggt tgacagtgat gatatccaga ccatatcctc tggctctgaa   3540

ggggatgact ttgaggacaa gaagaacatg actggtccaa tgaagcgtca agtggcagta   3600

aaatcaaccc gaggctttgc tcttaaatca acccatggga ttgcaattaa atcaaccaac   3660

atggcctctg tggacaaggg ggagagcgca cctgttcgta agaacacacg ccaattctat   3720

gatggcgagg agtcttgcta catcattgat gccaagcttg aaggcaacct gggccgctac   3780

ctcaaccaca gttgcagccc caacctgttt gtccagaatg tcttcgtgga tacccatgat   3840

cttcgcttcc cctgggtggc cttctttgcc agcaaaatcc gggctgggac agaacttact   3900

tgggactaca actacgaggt gggcagtgtg gaaggcaagg agctactctg ttgctgtggg   3960

gccattgaat gcagaggacg tcttctttag aggacagcct tcttcccaac ccttcttgaa   4020

ctgtcgtttc ctcaggaact gggtcttcct gattgttgaa ccctgacccg aagtctctgg   4080

gctagctact ccccccagct cctagttgat agaaatgggg gttctggacc agatgatccc   4140

ttccaatgtg gtgctagcag gcaggatccc ttctccacct ccaaaggccc taaagggtgg   4200

ggagagatca ccactctaac ctcggcctga catccctccc atcccatatt tgtccaagtg   4260

ttcctgcttc taacagactt tgttcttaga atggagcctg tgtatctact atctccagtt   4320

tgtattattt cttgaaagtc ttttaacaat atgataaaac taaaaaaaaa aaaaaaaaaa   4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         4420


<210>  644
<211>  1290
<212>  PRT
<213>  Homosapiens

<400>  644

Met Ser Ser Leu Pro Gly Cys Ile Gly Leu Asp Ala Ala Thr Ala Thr 
1               5                   10                  15      


Val Glu Ser Glu Glu Ile Ala Glu Leu Gln Gln Ala Val Val Glu Glu 
            20                  25                  30          


Leu Gly Ile Ser Met Glu Glu Leu Arg His Phe Ile Asp Glu Glu Leu 
        35                  40                  45              


Glu Lys Met Asp Cys Val Gln Gln Arg Lys Lys Gln Leu Ala Glu Leu 
    50                  55                  60                  


Glu Thr Trp Val Ile Gln Lys Glu Ser Glu Val Ala His Val Asp Gln 
65                  70                  75                  80  


Leu Phe Asp Asp Ala Ser Arg Ala Val Thr Asn Cys Glu Ser Leu Val 
                85                  90                  95      


Lys Asp Phe Tyr Ser Lys Leu Gly Leu Gln Tyr Arg Asp Ser Ser Ser 
            100                 105                 110         


Glu Asp Glu Ser Ser Arg Pro Thr Glu Ile Ile Glu Ile Pro Asp Glu 
        115                 120                 125             


Asp Asp Asp Val Leu Ser Ile Asp Ser Gly Asp Ala Gly Ser Arg Thr 
    130                 135                 140                 


Pro Lys Asp Gln Lys Leu Arg Glu Ala Met Ala Ala Leu Arg Lys Ser 
145                 150                 155                 160 


Ala Gln Asp Val Gln Lys Phe Met Asp Ala Val Asn Lys Lys Ser Ser 
                165                 170                 175     


Ser Gln Asp Leu His Lys Gly Thr Leu Ser Gln Met Ser Gly Glu Leu 
            180                 185                 190         


Ser Lys Asp Gly Asp Leu Ile Val Ser Met Arg Ile Leu Gly Lys Lys 
        195                 200                 205             


Arg Thr Lys Thr Trp His Lys Gly Thr Leu Ile Ala Ile Gln Thr Val 
    210                 215                 220                 


Gly Pro Gly Lys Lys Tyr Lys Val Lys Phe Asp Asn Lys Gly Lys Ser 
225                 230                 235                 240 


Leu Leu Ser Gly Asn His Ile Ala Tyr Asp Tyr His Pro Pro Ala Asp 
                245                 250                 255     


Lys Leu Tyr Val Gly Ser Arg Val Val Ala Lys Tyr Lys Asp Gly Asn 
            260                 265                 270         


Gln Val Trp Leu Tyr Ala Gly Ile Val Ala Glu Thr Pro Asn Val Lys 
        275                 280                 285             


Asn Lys Leu Arg Phe Leu Ile Phe Phe Asp Asp Gly Tyr Ala Ser Tyr 
    290                 295                 300                 


Val Thr Gln Ser Glu Leu Tyr Pro Ile Cys Arg Pro Leu Lys Lys Thr 
305                 310                 315                 320 


Trp Glu Asp Ile Glu Asp Ile Ser Cys Arg Asp Phe Ile Glu Glu Tyr 
                325                 330                 335     


Val Thr Ala Tyr Pro Asn Arg Pro Met Val Leu Leu Lys Ser Gly Gln 
            340                 345                 350         


Leu Ile Lys Thr Glu Trp Glu Gly Thr Trp Trp Lys Ser Arg Val Glu 
        355                 360                 365             


Glu Val Asp Gly Ser Leu Val Arg Ile Leu Phe Leu Asp Asp Lys Arg 
    370                 375                 380                 


Cys Glu Trp Ile Tyr Arg Gly Ser Thr Arg Leu Glu Pro Met Phe Ser 
385                 390                 395                 400 


Met Lys Thr Ser Ser Ala Ser Ala Leu Glu Lys Lys Gln Gly Gln Leu 
                405                 410                 415     


Arg Thr Arg Pro Asn Met Gly Ala Val Arg Ser Lys Gly Pro Val Val 
            420                 425                 430         


Gln Tyr Thr Gln Asp Leu Thr Gly Thr Gly Thr Gln Phe Lys Pro Val 
        435                 440                 445             


Glu Pro Pro Gln Pro Thr Ala Pro Pro Ala Pro Pro Phe Pro Pro Ala 
    450                 455                 460                 


Pro Pro Leu Ser Pro Gln Ala Gly Asp Ser Asp Leu Glu Ser Gln Leu 
465                 470                 475                 480 


Ala Gln Ser Arg Lys Gln Val Ala Lys Lys Ser Thr Ser Phe Arg Pro 
                485                 490                 495     


Gly Ser Val Gly Ser Gly His Ser Ser Ser Thr Ser Pro Ala Leu Ser 
            500                 505                 510         


Glu Asn Val Ser Gly Gly Lys Pro Gly Ile Asn Gln Thr Tyr Arg Ser 
        515                 520                 525             


Pro Leu Gly Ser Thr Ala Ser Ala Pro Ala Pro Ser Ala Leu Pro Ala 
    530                 535                 540                 


Pro Pro Ala Pro Pro Val Phe His Gly Met Leu Glu Arg Ala Pro Ala 
545                 550                 555                 560 


Glu Pro Ser Tyr Arg Ala Pro Met Glu Lys Leu Phe Tyr Leu Pro His 
                565                 570                 575     


Val Cys Ser Tyr Thr Cys Leu Ser Arg Val Arg Pro Met Arg Asn Glu 
            580                 585                 590         


Gln Tyr Arg Gly Lys Asn Pro Leu Leu Val Pro Leu Leu Tyr Asp Phe 
        595                 600                 605             


Arg Arg Met Thr Ala Arg Arg Arg Val Asn Arg Lys Met Gly Phe His 
    610                 615                 620                 


Val Ile Tyr Lys Thr Pro Cys Gly Leu Cys Leu Arg Thr Met Gln Glu 
625                 630                 635                 640 


Ile Glu Arg Tyr Leu Phe Glu Thr Gly Cys Asp Phe Leu Phe Leu Glu 
                645                 650                 655     


Met Phe Cys Leu Asp Pro Tyr Val Leu Val Asp Arg Lys Phe Gln Pro 
            660                 665                 670         


Tyr Lys Pro Phe Tyr Tyr Ile Leu Asp Ile Thr Tyr Gly Lys Glu Asp 
        675                 680                 685             


Val Pro Leu Ser Cys Val Asn Glu Ile Asp Thr Thr Pro Pro Pro Gln 
    690                 695                 700                 


Val Ala Tyr Ser Lys Glu Arg Ile Pro Gly Lys Gly Val Phe Ile Asn 
705                 710                 715                 720 


Thr Gly Pro Glu Phe Leu Val Gly Cys Asp Cys Lys Asp Gly Cys Arg 
                725                 730                 735     


Asp Lys Ser Lys Cys Ala Cys His Gln Leu Thr Ile Gln Ala Thr Ala 
            740                 745                 750         


Cys Thr Pro Gly Gly Gln Ile Asn Pro Asn Ser Gly Tyr Gln Tyr Lys 
        755                 760                 765             


Arg Leu Glu Glu Cys Leu Pro Thr Gly Val Tyr Glu Cys Asn Lys Arg 
    770                 775                 780                 


Cys Lys Cys Asp Pro Asn Met Cys Thr Asn Arg Leu Val Gln His Gly 
785                 790                 795                 800 


Leu Gln Val Arg Leu Gln Leu Phe Lys Thr Gln Asn Lys Gly Trp Gly 
                805                 810                 815     


Ile Arg Cys Leu Asp Asp Ile Ala Lys Gly Ser Phe Val Cys Ile Tyr 
            820                 825                 830         


Ala Gly Lys Ile Leu Thr Asp Asp Phe Ala Asp Lys Glu Gly Leu Glu 
        835                 840                 845             


Met Gly Asp Glu Tyr Phe Ala Asn Leu Asp His Ile Glu Ser Val Glu 
    850                 855                 860                 


Asn Phe Lys Glu Gly Tyr Glu Ser Asp Ala Pro Cys Ser Ser Asp Ser 
865                 870                 875                 880 


Ser Gly Val Asp Leu Lys Asp Gln Glu Asp Gly Asn Ser Gly Thr Glu 
                885                 890                 895     


Asp Pro Glu Glu Ser Asn Asp Asp Ser Ser Asp Asp Asn Phe Cys Lys 
            900                 905                 910         


Asp Glu Asp Phe Ser Thr Ser Ser Val Trp Arg Ser Tyr Ala Thr Arg 
        915                 920                 925             


Arg Gln Thr Arg Gly Gln Lys Glu Asn Gly Leu Ser Glu Thr Thr Ser 
    930                 935                 940                 


Lys Asp Ser His Pro Pro Asp Leu Gly Pro Pro His Ile Pro Val Pro 
945                 950                 955                 960 


Pro Ser Ile Pro Val Gly Gly Cys Asn Pro Pro Ser Ser Glu Glu Thr 
                965                 970                 975     


Pro Lys Asn Lys Val Ala Ser Trp Leu Ser Cys Asn Ser Val Ser Glu 
            980                 985                 990         


Gly Gly Phe Ala Asp Ser Asp Ser  His Ser Ser Phe Lys  Thr Asn Glu 
        995                 1000                 1005             


Gly Gly  Glu Gly Arg Ala Gly  Gly Ser Arg Met Glu  Ala Glu Lys 
    1010                 1015                 1020             


Ala Ser  Thr Ser Gly Leu Gly  Ile Lys Asp Glu Gly  Asp Ile Lys 
    1025                 1030                 1035             


Gln Ala  Lys Lys Glu Asp Thr  Asp Asp Arg Asn Lys  Met Ser Val 
    1040                 1045                 1050             


Val Thr  Glu Ser Ser Arg Asn  Tyr Gly Tyr Asn Pro  Ser Pro Val 
    1055                 1060                 1065             


Lys Pro  Glu Gly Leu Arg Arg  Pro Pro Ser Lys Thr  Ser Met His 
    1070                 1075                 1080             


Gln Ser  Arg Arg Leu Met Ala  Ser Ala Gln Ser Asn  Pro Asp Asp 
    1085                 1090                 1095             


Val Leu  Thr Leu Ser Ser Ser  Thr Glu Ser Glu Gly  Glu Ser Gly 
    1100                 1105                 1110             


Thr Ser  Arg Lys Pro Thr Ala  Gly Gln Thr Ser Ala  Thr Ala Val 
    1115                 1120                 1125             


Asp Ser  Asp Asp Ile Gln Thr  Ile Ser Ser Gly Ser  Glu Gly Asp 
    1130                 1135                 1140             


Asp Phe  Glu Asp Lys Lys Asn  Met Thr Gly Pro Met  Lys Arg Gln 
    1145                 1150                 1155             


Val Ala  Val Lys Ser Thr Arg  Gly Phe Ala Leu Lys  Ser Thr His 
    1160                 1165                 1170             


Gly Ile  Ala Ile Lys Ser Thr  Asn Met Ala Ser Val  Asp Lys Gly 
    1175                 1180                 1185             


Glu Ser  Ala Pro Val Arg Lys  Asn Thr Arg Gln Phe  Tyr Asp Gly 
    1190                 1195                 1200             


Glu Glu  Ser Cys Tyr Ile Ile  Asp Ala Lys Leu Glu  Gly Asn Leu 
    1205                 1210                 1215             


Gly Arg  Tyr Leu Asn His Ser  Cys Ser Pro Asn Leu  Phe Val Gln 
    1220                 1225                 1230             


Asn Val  Phe Val Asp Thr His  Asp Leu Arg Phe Pro  Trp Val Ala 
    1235                 1240                 1245             


Phe Phe  Ala Ser Lys Ile Arg  Ala Gly Thr Glu Leu  Thr Trp Asp 
    1250                 1255                 1260             


Tyr Asn  Tyr Glu Val Gly Ser  Val Glu Gly Lys Glu  Leu Leu Cys 
    1265                 1270                 1275             


Cys Cys  Gly Ala Ile Glu Cys  Arg Gly Arg Leu Leu  
    1280                 1285                 1290 


<210>  645
<211>  2178
<212>  DNA
<213>  Homosapiens

<400>  645
tttttttccc ggctgggctc gggctcagct cgactgggct cggcgggcgg cggcggcggc     60

gccggcggct ggcggaggag ggagggcgag ggcgggcgcg ggccggcggg cgggcggaag    120

agggaggaga ggcgcgggga gccaggcctc ggggcctcgg agcaaccacc cgagcagacg    180

gagtacacgg agcagcggcc ccggccccgc caacgctgcc gccgggtacg tggctacacc    240

actggctgcc ctcttgaaca taaaggagaa aactcggctg cgggcacctc ccaacgccac    300

cttggaacat ttctacctga ccagtggcaa gcagcccaag caggtggaag tagagctttt    360

gtcccggcag agcgggctct ctggccgcca ggtagagcgt tggttccgtc gccgccgcaa    420

ccaggaccgg cccagtctcc tcaagaagtt ccgagaagcc agctggagat tcacatttta    480

cctgattgcc ttcattgccg gcatggccgt cattgtggat aaaccctggt tctatgacat    540

gaagaaagtt tgggagggat atcccataca gagcactatc ccttcccagt attggtacta    600

catgattgaa ctttccttct actggtccct gctcttcagc attgcctctg atgtcaagcg    660

aaaggatttc aaggaacaga tcatccacca tgtggccacc atcattctca tcagcttttc    720

ctggtttgcc aattacatcc gagctgggac tctaatcatg gctctgcatg actcttccga    780

ttacctgctg gagtcagcca agatgtttaa ctacgcggga tggaagaaca cctgcaacaa    840

catcttcatc gtcttcgcca ttgtttttat catcacccga ctggtcatcc tgcccttctg    900

gatcctgcat tgcaccctgg tgtacccact ggagctctat cctgccttct ttggctatta    960

cttcttcaat tccatgatgg gagttctaca gctgctgcat atcttctggg cctacctcat   1020

tttgcgcatg gcccacaagt tcataactgg aaagctggta gaagatgaac gcagtgaccg   1080

ggaagaaaca gagagctcag agggggagga ggctgcagct gggggaggag caaagagccg   1140

gcccctagcc aatggccacc ccatcctcaa taacaaccat cgtaagaatg actgaaccat   1200

tattccagct gcctcccaga ttaatgcata aagccaagga actaccccgc tccctgcgct   1260

atagggtcac tttaagctct ggggaaaaag gagaaagtga gaggagagtt ctctgcatcc   1320

tccctccttg cttgtcaccc agttgccttt aaaccaaatt ctaaccagcc tatccccagg   1380

tagggggacg ttggttatat tctgttagag ggggacggtc gtattttcct ccctacccgc   1440

caagtcatcc tttctactgc ttttgaggcc ctccctcagc tctctgtggg taggggttac   1500

aattcacatt ccttattctg agaatttggc cccagctgtt tgcctttgac tccctgacct   1560

ccagagccag ggttgtgcct tattgtccca tctgtgggcc tcattctgcc aaagctggac   1620

caaggctaac ctttctaagc tccctaactt gggccagaaa ccaaagctga gcttttaact   1680

ttctccctct atgacacaaa tgaattgagg gtaggaggag ggtgcacata acccttaccc   1740

tacctctgcc aaaaagtggg ggctgtactg gggactgctc ggatgatctt tcttagtgct   1800

acttctttca gctgtccctg tagcgacagg tctaagatct gactgcctcc tcctttctct   1860

ggcctcttcc cccttccctc ttctcttcag ctaggctagc tggtttggag tagaatggca   1920

actaattcta atttttattt attaaatatt tggggttttg gttttaaagc cagaattacg   1980

gctagcacct agcatttcag cagagggacc attttagacc aaaatgtact gttaatgggt   2040

ttttttttaa aattaaaaga ttaaataaaa aatattaaat aaaacatggc aataagtgtc   2100

agactattag gaattgagaa gggggatcaa ctaaataaac gaagagagtc tttcttaaaa   2160

aaaaaaaaaa aaaaaaaa                                                 2178


<210>  646
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  646

Met Ala Val Ile Val Asp Lys Pro Trp Phe Tyr Asp Met Lys Lys Val 
1               5                   10                  15      


Trp Glu Gly Tyr Pro Ile Gln Ser Thr Ile Pro Ser Gln Tyr Trp Tyr 
            20                  25                  30          


Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser Leu Leu Phe Ser Ile Ala 
        35                  40                  45              


Ser Asp Val Lys Arg Lys Asp Phe Lys Glu Gln Ile Ile His His Val 
    50                  55                  60                  


Ala Thr Ile Ile Leu Ile Ser Phe Ser Trp Phe Ala Asn Tyr Ile Arg 
65                  70                  75                  80  


Ala Gly Thr Leu Ile Met Ala Leu His Asp Ser Ser Asp Tyr Leu Leu 
                85                  90                  95      


Glu Ser Ala Lys Met Phe Asn Tyr Ala Gly Trp Lys Asn Thr Cys Asn 
            100                 105                 110         


Asn Ile Phe Ile Val Phe Ala Ile Val Phe Ile Ile Thr Arg Leu Val 
        115                 120                 125             


Ile Leu Pro Phe Trp Ile Leu His Cys Thr Leu Val Tyr Pro Leu Glu 
    130                 135                 140                 


Leu Tyr Pro Ala Phe Phe Gly Tyr Tyr Phe Phe Asn Ser Met Met Gly 
145                 150                 155                 160 


Val Leu Gln Leu Leu His Ile Phe Trp Ala Tyr Leu Ile Leu Arg Met 
                165                 170                 175     


Ala His Lys Phe Ile Thr Gly Lys Leu Val Glu Asp Glu Arg Ser Asp 
            180                 185                 190         


Arg Glu Glu Thr Glu Ser Ser Glu Gly Glu Glu Ala Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Lys Ser Arg Pro Leu Ala Asn Gly His Pro Ile Leu Asn Asn 
    210                 215                 220                 


Asn His Arg Lys Asn Asp 
225                 230 


<210>  647
<211>  2352
<212>  DNA
<213>  Homosapiens

<400>  647
tttttttccc ggctgggctc gggctcagct cgactgggct cggcgggcgg cggcggcggc     60

gccggcggct ggcggaggag ggagggcgag ggcgggcgcg ggccggcggg cgggcggaag    120

agggaggaga ggcgcgggga gccaggcctc ggggcctcgg agcaaccacc cgagcagacg    180

gagtacacgg agcagcggcc ccggccccgc caacgctgcc gccgggatgc tccagacctt    240

gtatgattac ttctggtggg aacgtctgtg gctgcctgtg aacttgacct gggccgatct    300

agaagaccga gatggacgtg tctacgccaa agcctcagat ctctatatca cgctgcccct    360

ggccttgctc ttcctcatcg ttcgatactt ctttgagctg tacgtggcta caccactggc    420

tgccctcttg aacataaagg agaaaactcg gctgcgggca cctcccaacg ccaccttgga    480

acatttctac ctgaccagtg gcaagcagcc caagcaggtg gaagtagagc ttttgtcccg    540

gcagagcggg ctctctggcc gccaggtaga gcgttggttc cgtcgccgcc gcaaccagga    600

ccggcccagt ctcctcaaga agttccgaga agccagctgg agattcacat tttacctgat    660

tgccttcatt gccggcatgg ccgtcattgt ggataaaccc tggttctatg acatgaagaa    720

agtttgggag ggatatccca tacagagcac tatcccttcc cagtattggt actacatgat    780

tgaactttcc ttctactggt ccctgctctt cagcattgcc tctgatgtca agcgaaagga    840

tttcaaggaa cagatcatcc accatgtggc caccatcatt ctcatcagct tttcctggtt    900

tgccaattac atccgagctg ggactctaat catggctctg catgactctt ccgattacct    960

gctggagtca gccaagatgt ttaactacgc gggatggaag aacacctgca acaacatctt   1020

catcgtcttc gccattgttt ttatcatcac ccgactggtc atcctgccct tctggatcct   1080

gcattgcacc ctggtgtacc cactggagct ctatcctgcc ttctttggct attacttctt   1140

caattccatg atgggagttc tacagctgct gcatatcttc tgggcctacc tcattttgcg   1200

catggcccac aagttcataa ctggaaagct ggtagaagat gaacgcagtg accgggaaga   1260

aacagagagc tcagaggggg aggaggctgc agctggggga ggagcaaaga gccggcccct   1320

agccaatggc caccccatcc tcaataacaa ccatcgtaag aatgactgaa ccattattcc   1380

agctgcctcc cagattaatg cataaagcca aggaactacc ccgctccctg cgctataggg   1440

tcactttaag ctctggggaa aaaggagaaa gtgagaggag agttctctgc atcctccctc   1500

cttgcttgtc acccagttgc ctttaaacca aattctaacc agcctatccc caggtagggg   1560

gacgttggtt atattctgtt agagggggac ggtcgtattt tcctccctac ccgccaagtc   1620

atcctttcta ctgcttttga ggccctccct cagctctctg tgggtagggg ttacaattca   1680

cattccttat tctgagaatt tggccccagc tgtttgcctt tgactccctg acctccagag   1740

ccagggttgt gccttattgt cccatctgtg ggcctcattc tgccaaagct ggaccaaggc   1800

taacctttct aagctcccta acttgggcca gaaaccaaag ctgagctttt aactttctcc   1860

ctctatgaca caaatgaatt gagggtagga ggagggtgca cataaccctt accctacctc   1920

tgccaaaaag tgggggctgt actggggact gctcggatga tctttcttag tgctacttct   1980

ttcagctgtc cctgtagcga caggtctaag atctgactgc ctcctccttt ctctggcctc   2040

ttcccccttc cctcttctct tcagctaggc tagctggttt ggagtagaat ggcaactaat   2100

tctaattttt atttattaaa tatttggggt tttggtttta aagccagaat tacggctagc   2160

acctagcatt tcagcagagg gaccatttta gaccaaaatg tactgttaat gggttttttt   2220

ttaaaattaa aagattaaat aaaaaatatt aaataaaaca tggcaataag tgtcagacta   2280

ttaggaattg agaaggggga tcaactaaat aaacgaagag agtctttctt aaaaaaaaaa   2340

aaaaaaaaaa aa                                                       2352


<210>  648
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  648

Met Leu Gln Thr Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Thr Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Thr Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Thr Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Thr Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Thr Leu Glu His Phe Tyr Leu Thr Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Thr Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Thr Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Thr Ile Ile Leu Ile Ser Phe Ser Trp 
    210                 215                 220                 


Phe Ala Asn Tyr Ile Arg Ala Gly Thr Leu Ile Met Ala Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ser Ala Lys Met Phe Asn Tyr Ala Gly 
                245                 250                 255     


Trp Lys Asn Thr Cys Asn Asn Ile Phe Ile Val Phe Ala Ile Val Phe 
            260                 265                 270         


Ile Ile Thr Arg Leu Val Ile Leu Pro Phe Trp Ile Leu His Cys Thr 
        275                 280                 285             


Leu Val Tyr Pro Leu Glu Leu Tyr Pro Ala Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Ser Met Met Gly Val Leu Gln Leu Leu His Ile Phe Trp Ala 
305                 310                 315                 320 


Tyr Leu Ile Leu Arg Met Ala His Lys Phe Ile Thr Gly Lys Leu Val 
                325                 330                 335     


Glu Asp Glu Arg Ser Asp Arg Glu Glu Thr Glu Ser Ser Glu Gly Glu 
            340                 345                 350         


Glu Ala Ala Ala Gly Gly Gly Ala Lys Ser Arg Pro Leu Ala Asn Gly 
        355                 360                 365             


His Pro Ile Leu Asn Asn Asn His Arg Lys Asn Asp 
    370                 375                 380 


<210>  649
<211>  2392
<212>  DNA
<213>  Homosapiens

<400>  649
tttttttccc ggctgggctc gggctcagct cgactgggct cggcgggcgg cggcggcggc     60

gccggcggct ggcggaggag ggagggcgag ggcgggcgcg ggccggcggg cgggcggaag    120

agggaggaga ggcgcgggga gccaggcctc ggggcctcgg agcaaccacc cgagcagacg    180

gagtacacgg agcagcggcc ccggccccgc caacgctgcc gccggctact ccctcttgat    240

gccctcccct ttgcccctca ctcaggatgc tccagacctt gtatgattac ttctggtggg    300

aacgtctgtg gctgcctgtg aacttgacct gggccgatct agaagaccga gatggacgtg    360

tctacgccaa agcctcagat ctctatatca cgctgcccct ggccttgctc ttcctcatcg    420

ttcgatactt ctttgagctg tacgtggcta caccactggc tgccctcttg aacataaagg    480

agaaaactcg gctgcgggca cctcccaacg ccaccttgga acatttctac ctgaccagtg    540

gcaagcagcc caagcaggtg gaagtagagc ttttgtcccg gcagagcggg ctctctggcc    600

gccaggtaga gcgttggttc cgtcgccgcc gcaaccagga ccggcccagt ctcctcaaga    660

agttccgaga agccagctgg agattcacat tttacctgat tgccttcatt gccggcatgg    720

ccgtcattgt ggataaaccc tggttctatg acatgaagaa agtttgggag ggatatccca    780

tacagagcac tatcccttcc cagtattggt actacatgat tgaactttcc ttctactggt    840

ccctgctctt cagcattgcc tctgatgtca agcgaaagga tttcaaggaa cagatcatcc    900

accatgtggc caccatcatt ctcatcagct tttcctggtt tgccaattac atccgagctg    960

ggactctaat catggctctg catgactctt ccgattacct gctggagtca gccaagatgt   1020

ttaactacgc gggatggaag aacacctgca acaacatctt catcgtcttc gccattgttt   1080

ttatcatcac ccgactggtc atcctgccct tctggatcct gcattgcacc ctggtgtacc   1140

cactggagct ctatcctgcc ttctttggct attacttctt caattccatg atgggagttc   1200

tacagctgct gcatatcttc tgggcctacc tcattttgcg catggcccac aagttcataa   1260

ctggaaagct ggtagaagat gaacgcagtg accgggaaga aacagagagc tcagaggggg   1320

aggaggctgc agctggggga ggagcaaaga gccggcccct agccaatggc caccccatcc   1380

tcaataacaa ccatcgtaag aatgactgaa ccattattcc agctgcctcc cagattaatg   1440

cataaagcca aggaactacc ccgctccctg cgctataggg tcactttaag ctctggggaa   1500

aaaggagaaa gtgagaggag agttctctgc atcctccctc cttgcttgtc acccagttgc   1560

ctttaaacca aattctaacc agcctatccc caggtagggg gacgttggtt atattctgtt   1620

agagggggac ggtcgtattt tcctccctac ccgccaagtc atcctttcta ctgcttttga   1680

ggccctccct cagctctctg tgggtagggg ttacaattca cattccttat tctgagaatt   1740

tggccccagc tgtttgcctt tgactccctg acctccagag ccagggttgt gccttattgt   1800

cccatctgtg ggcctcattc tgccaaagct ggaccaaggc taacctttct aagctcccta   1860

acttgggcca gaaaccaaag ctgagctttt aactttctcc ctctatgaca caaatgaatt   1920

gagggtagga ggagggtgca cataaccctt accctacctc tgccaaaaag tgggggctgt   1980

actggggact gctcggatga tctttcttag tgctacttct ttcagctgtc cctgtagcga   2040

caggtctaag atctgactgc ctcctccttt ctctggcctc ttcccccttc cctcttctct   2100

tcagctaggc tagctggttt ggagtagaat ggcaactaat tctaattttt atttattaaa   2160

tatttggggt tttggtttta aagccagaat tacggctagc acctagcatt tcagcagagg   2220

gaccatttta gaccaaaatg tactgttaat gggttttttt ttaaaattaa aagattaaat   2280

aaaaaatatt aaataaaaca tggcaataag tgtcagacta ttaggaattg agaaggggga   2340

tcaactaaat aaacgaagag agtctttctt aaaaaaaaaa aaaaaaaaaa aa           2392


<210>  650
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  650

Met Leu Gln Thr Leu Tyr Asp Tyr Phe Trp Trp Glu Arg Leu Trp Leu 
1               5                   10                  15      


Pro Val Asn Leu Thr Trp Ala Asp Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Thr Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val Ala Thr Pro Leu 
    50                  55                  60                  


Ala Ala Leu Leu Asn Ile Lys Glu Lys Thr Arg Leu Arg Ala Pro Pro 
65                  70                  75                  80  


Asn Ala Thr Leu Glu His Phe Tyr Leu Thr Ser Gly Lys Gln Pro Lys 
                85                  90                  95      


Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly Leu Ser Gly Arg 
            100                 105                 110         


Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Ser 
        115                 120                 125             


Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe Thr Phe Tyr Leu 
    130                 135                 140                 


Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp Lys Pro Trp Phe 
145                 150                 155                 160 


Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile Gln Ser Thr Ile 
                165                 170                 175     


Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser Phe Tyr Trp Ser 
            180                 185                 190         


Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Ile Ile His His Val Ala Thr Ile Ile Leu Ile Ser Phe Ser Trp 
    210                 215                 220                 


Phe Ala Asn Tyr Ile Arg Ala Gly Thr Leu Ile Met Ala Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ser Ala Lys Met Phe Asn Tyr Ala Gly 
                245                 250                 255     


Trp Lys Asn Thr Cys Asn Asn Ile Phe Ile Val Phe Ala Ile Val Phe 
            260                 265                 270         


Ile Ile Thr Arg Leu Val Ile Leu Pro Phe Trp Ile Leu His Cys Thr 
        275                 280                 285             


Leu Val Tyr Pro Leu Glu Leu Tyr Pro Ala Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Ser Met Met Gly Val Leu Gln Leu Leu His Ile Phe Trp Ala 
305                 310                 315                 320 


Tyr Leu Ile Leu Arg Met Ala His Lys Phe Ile Thr Gly Lys Leu Val 
                325                 330                 335     


Glu Asp Glu Arg Ser Asp Arg Glu Glu Thr Glu Ser Ser Glu Gly Glu 
            340                 345                 350         


Glu Ala Ala Ala Gly Gly Gly Ala Lys Ser Arg Pro Leu Ala Asn Gly 
        355                 360                 365             


His Pro Ile Leu Asn Asn Asn His Arg Lys Asn Asp 
    370                 375                 380 


<210>  651
<211>  1772
<212>  DNA
<213>  Homosapiens

<400>  651
cgctgagagg ctgagtggag ttcactcaca tggattgagg cccagttcct gggagaagag     60

atgctgggca ggaaggtgtc tgcatgtggg actctgtaca gcccggtcct ctcccacatc    120

tgggaggggc cagagtcaga caactgctgg gttcgtccct aagagaggtc atctgactgg    180

ctgttcagcc taggctgcac acacccccac tttcctctac caggccacac cggagcagtg    240

ctcacacagg caatctacca ggccacaaca acgacaccca cctcacctct ggcacctctg    300

agcatccacg tacttgcaag aactcttgct cacatcagct aagagattgc acctgctgac    360

ctagagattc cggcctgtgc tcctgtgctg ctgagcaggg caaccagtag caccatgtct    420

gtgactggcg gggaagatgg caccgtccct cacccaggag atcctcagcc acctgggcct    480

ggccagcaag actgcagcgt gggggaccct gggcaccctc aggaccttct tgaacttcag    540

cgtggacaag gatgcgcaga ggctactgag ggccattact ggccaaggcg tggaccgcag    600

tgccattgtg gacgtgctga ccaaccggag cagagagcaa aggcagctca tctcacgaaa    660

cttccaggag cgcacccaac aggacctgat gaagtctcta caggcagcac tttccggcaa    720

cctggagagg attgtgatgg ctctgctgca gcccacagcc cagtttgacg cccaggaatt    780

gaggacagct ctgaaggcct cagattctgc tgtggacgtg gccattgaaa ttcttgccac    840

tcgaacccca ccccagctgc aggagtgcct ggcagtctac aaacacaatt tccaggtgga    900

ggctgtggat ggcatcacat ctgagaccag tggcatcttg caggacctgc tgttggccct    960

ggccaagggg ggccgtgaca gctactctgg aatcattgac tataatctgg cagaacaaga   1020

tgtccaggca ctgcagcggg cagaaggacc tagcagagag gaaacatggg tcccagtctt   1080

cacccagcga aatcctgaac acctcatccg agtgtttgat cagtaccagc ggagcactgg   1140

gcaagagctg gaggaggctg tccagaaccg tttccatgga gatgctcagg tggctctgct   1200

cggcctagct tcggtgatca agaacacacc gctgtacttt gctgacaaac ttcatcaagc   1260

cctccaggaa actgagccca attaccaagt cctgattcgc atccttatct ctcgatgtga   1320

gactgacctt ctgagtatca gagctgagtt caggaagaaa tttgggaagt ccctctactc   1380

ttctctccag gatgcagtga aaggggattg ccagtcagcc ctcctggcct tgtgcagggc   1440

tgaagacatg tgagacttcc ctgccccacc ccacatgaca tccgaggatc tgagatttcc   1500

gtgtttggct gaacctggga gaccagctgg gcctccaagt aggataaccc ctcactgagc   1560

accacattct ctagcttctt gttgaggctg gaactgtttc tttaaaatcc cttaattttc   1620

ccatctcaaa attatatctg tacctgggtc atccagctcc ttcttgggtg tggggaaatg   1680

agttttcttt gatagtttct gcctcactca tccctcctgt accctggcca gaacatctca   1740

ctgatactcg aattcttttg gcaaaaaaaa aa                                 1772


<210>  652
<211>  338
<212>  PRT
<213>  Homosapiens

<400>  652

Met Ala Pro Ser Leu Thr Gln Glu Ile Leu Ser His Leu Gly Leu Ala 
1               5                   10                  15      


Ser Lys Thr Ala Ala Trp Gly Thr Leu Gly Thr Leu Arg Thr Phe Leu 
            20                  25                  30          


Asn Phe Ser Val Asp Lys Asp Ala Gln Arg Leu Leu Arg Ala Ile Thr 
        35                  40                  45              


Gly Gln Gly Val Asp Arg Ser Ala Ile Val Asp Val Leu Thr Asn Arg 
    50                  55                  60                  


Ser Arg Glu Gln Arg Gln Leu Ile Ser Arg Asn Phe Gln Glu Arg Thr 
65                  70                  75                  80  


Gln Gln Asp Leu Met Lys Ser Leu Gln Ala Ala Leu Ser Gly Asn Leu 
                85                  90                  95      


Glu Arg Ile Val Met Ala Leu Leu Gln Pro Thr Ala Gln Phe Asp Ala 
            100                 105                 110         


Gln Glu Leu Arg Thr Ala Leu Lys Ala Ser Asp Ser Ala Val Asp Val 
        115                 120                 125             


Ala Ile Glu Ile Leu Ala Thr Arg Thr Pro Pro Gln Leu Gln Glu Cys 
    130                 135                 140                 


Leu Ala Val Tyr Lys His Asn Phe Gln Val Glu Ala Val Asp Gly Ile 
145                 150                 155                 160 


Thr Ser Glu Thr Ser Gly Ile Leu Gln Asp Leu Leu Leu Ala Leu Ala 
                165                 170                 175     


Lys Gly Gly Arg Asp Ser Tyr Ser Gly Ile Ile Asp Tyr Asn Leu Ala 
            180                 185                 190         


Glu Gln Asp Val Gln Ala Leu Gln Arg Ala Glu Gly Pro Ser Arg Glu 
        195                 200                 205             


Glu Thr Trp Val Pro Val Phe Thr Gln Arg Asn Pro Glu His Leu Ile 
    210                 215                 220                 


Arg Val Phe Asp Gln Tyr Gln Arg Ser Thr Gly Gln Glu Leu Glu Glu 
225                 230                 235                 240 


Ala Val Gln Asn Arg Phe His Gly Asp Ala Gln Val Ala Leu Leu Gly 
                245                 250                 255     


Leu Ala Ser Val Ile Lys Asn Thr Pro Leu Tyr Phe Ala Asp Lys Leu 
            260                 265                 270         


His Gln Ala Leu Gln Glu Thr Glu Pro Asn Tyr Gln Val Leu Ile Arg 
        275                 280                 285             


Ile Leu Ile Ser Arg Cys Glu Thr Asp Leu Leu Ser Ile Arg Ala Glu 
    290                 295                 300                 


Phe Arg Lys Lys Phe Gly Lys Ser Leu Tyr Ser Ser Leu Gln Asp Ala 
305                 310                 315                 320 


Val Lys Gly Asp Cys Gln Ser Ala Leu Leu Ala Leu Cys Arg Ala Glu 
                325                 330                 335     


Asp Met 
        


<210>  653
<211>  2687
<212>  DNA
<213>  Homosapiens

<400>  653
ctggcagccc ccttcattgc acctatctcc cccatctcat tgccacggct gaaccctcct     60

tctcaatctt ggaacagcac ccccttcttt aagggaagct gactccaccc atgtgttcaa    120

tcccaccagt cttccctccc aagtctggaa gccccacgac ctcttggtct catctggtca    180

cagcaagtta gaggtggaaa gagctcagca cggggccctt ctgtttacac atatactgcc    240

catagccagg agttactgca caaacactag ccagccttct acactacatt ccttttccaa    300

gacttttctg ggttagtttg ctttccagcc cactgatttc cttcttattg gacaggtcac    360

tcttttgcat cccaagcctg gcttaggcaa gtccctgagg ttagtaaaca ccttcagtgc    420

ccctcagccg agtccctttt gaccatggaa taccatcagc ctgaggatcc agcccctggt    480

aaggccggga ctgcagaagc agtcatccct gaaaaccatg aggttctggc aggcccagat    540

gagcaccctc aggacacaga tgcaagagat gctgatgggg aggctagaga acgggagcca    600

gcagaccaag ctttgctgcc tagccagtgt ggggacaacc ttgagtcccc tctgcctgaa    660

gctagctcag ctccaccggg gccaaccctt gggacactgc ctgaagtaga gacaataagg    720

gcatgctcca tgccccagga gcttcctcag tcccccagga cccgacagcc tgagccagat    780

ttctactgtg tcaagtggat cccttggaaa ggagaacaga cacccatcat cacccagagc    840

actaacggcc cttgccctct ccttgccatc atgaacatcc tctttcttca gtggaaggtg    900

aagctccccc cgcagaagga agtgatcaca tcggatgagc tcatggccca tcttggaaac    960

tgcctcctgt ccatcaagcc ccaggagaag tcagagggac ttcagcttaa ttttcagcag   1020

aatgtggatg atgcaatgac agtgctgcct aaactggcca caggtctgga tgtcaatgtg   1080

cgattcacag gcgtctctga ttttgagtat acacccgagt gcagtgtctt tgacctgcta   1140

ggcatacctc tgtaccatgg ctggcttgtt gatccacaga gtcctgaggc tgtgcgtgca   1200

gttgggaaac tgagttacaa ccagctggtg gagaggatca tcacctgcaa acactccagt   1260

gacaccaacc tcgtgacaga aggcctgatt gcagagcagt tcctggagac caccgcggcc   1320

cagctgacct accacggact gtgtgagctg acagcagctg ctaaggaggg tgaacttagc   1380

gtctttttcc gaaacaacca ctttagcacc atgactaagc ataagagtca cttataccta   1440

ctggtcactg accagggctt tctacaggag gagcaagtcg tatgggagag cctgcacaat   1500

gtggatggag acagctgctt ttgtgactct gactttcacc tgagtcattc cctgggcaag   1560

gggcctggag cagaaggtgg gagtggctcc ccagaaaagc agctgcaggt agaccaggac   1620

tacctgattg ctctgtccct gcagcagcaa cagccacgag gcccgctggg gcttaccgac   1680

ttggagctgg cccagcagct tcagcaagag gagtatcaac agcagcaggc agcgcagcca   1740

gtgcggatgc ggacgcgggt cctgtcactg caggggagag gagccacatc tggacgccca   1800

gccggggagc gtcggcagag gccgaagcac gagtcagact gcattctgct gtagctctgc   1860

cccagtgcca ggctggcctg ccccttcttc cagaggctat ggctagttgg cttgctcccc   1920

cgcctccacc cctgagatgt gctggataac ttatttatgg actgttgggg atgagagcag   1980

gcaacaaatg ccaaggtcag acttggtaat gtccttgacc tcacgtgctg ctgccttctc   2040

tgcctcccac ccagggcaac actaggattg gtgggtttct ggttctcaac tcccggtccc   2100

tgaatagtca cacgtatgta cagactgagg ctctggggtg aggtccctat ccagaatgca   2160

tctcttctgc ttcccatccc tgctgcctgg atgctcctga tcacctaggc aggcctgtct   2220

ccagttgttt cagagcttaa tttgggtttc tatctcttat ttgtaatgcc ttcctggggt   2280

ttggaaataa aacttctggc cgggcacggt ggctcactcc tgtaatctca acaatttgag   2340

aggccaaggt gggcggatca cctgaggtta ggagttcgag accagcctgc ccaaaaaggt   2400

gaaaccccgt ctctactgaa aatacaagaa attagctggg actacaggca tgcgccactg   2460

cgcccagctg atttttgtat ttttagtaga gacggtttcg ccactttggt caggctggtc   2520

ttgaattcct gacctcaggt gatccgcctg ccttggcctc ccgaagtgct ggaattacag   2580

gcgtgagcca ctgcgcccag ctacctgtca tttctaatat agcctgcagg gggaaccaaa   2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2687


<210>  654
<211>  469
<212>  PRT
<213>  Homosapiens

<400>  654

Met Glu Tyr His Gln Pro Glu Asp Pro Ala Pro Gly Lys Ala Gly Thr 
1               5                   10                  15      


Ala Glu Ala Val Ile Pro Glu Asn His Glu Val Leu Ala Gly Pro Asp 
            20                  25                  30          


Glu His Pro Gln Asp Thr Asp Ala Arg Asp Ala Asp Gly Glu Ala Arg 
        35                  40                  45              


Glu Arg Glu Pro Ala Asp Gln Ala Leu Leu Pro Ser Gln Cys Gly Asp 
    50                  55                  60                  


Asn Leu Glu Ser Pro Leu Pro Glu Ala Ser Ser Ala Pro Pro Gly Pro 
65                  70                  75                  80  


Thr Leu Gly Thr Leu Pro Glu Val Glu Thr Ile Arg Ala Cys Ser Met 
                85                  90                  95      


Pro Gln Glu Leu Pro Gln Ser Pro Arg Thr Arg Gln Pro Glu Pro Asp 
            100                 105                 110         


Phe Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile 
        115                 120                 125             


Ile Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn 
    130                 135                 140                 


Ile Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val 
145                 150                 155                 160 


Ile Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser 
                165                 170                 175     


Ile Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln 
            180                 185                 190         


Asn Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu 
        195                 200                 205             


Asp Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro 
    210                 215                 220                 


Glu Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp 
225                 230                 235                 240 


Leu Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu 
                245                 250                 255     


Ser Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser 
            260                 265                 270         


Asp Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu 
        275                 280                 285             


Thr Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala 
    290                 295                 300                 


Ala Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe 
305                 310                 315                 320 


Ser Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp 
                325                 330                 335     


Gln Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn 
            340                 345                 350         


Val Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His 
        355                 360                 365             


Ser Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu 
    370                 375                 380                 


Lys Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln 
385                 390                 395                 400 


Gln Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala 
                405                 410                 415     


Gln Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro 
            420                 425                 430         


Val Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr 
        435                 440                 445             


Ser Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser 
    450                 455                 460                 


Asp Cys Ile Leu Leu 
465                 


<210>  655
<211>  2995
<212>  DNA
<213>  Homosapiens

<400>  655
gcgggttcga gtcccgcctc ctgactctgg cctctagtcc ctgagtcccg ggcgggctgc     60

attcgtcggg gaaacctctc ctcgaccagg ggcacctcta ctcgaccagg ggcgacggcg    120

tactttgggc ttcatcatgg aggactacct gcagggttgt cgagctgctc tgcaggagtc    180

ccgacctcta catgttgtgc tgggaaatga agcctgtgat ttggactcca cagtgtctgc    240

tcttgccctg gctttttacc tagcaaagac aactgaggct gaggaagtct ttgtgccagt    300

tttaaatata aaacgttctg aactacctct gcgaggtgac attgtcttct ttcttcagaa    360

ggttcatatt ccagagagta tcttgatttt tcgggatgag attgacctcc atgcattata    420

ccaggctggc caactcaccc tcatccttgt cgaccatcat atcttatcca aaagtgacac    480

agccctagag gaggcagtag cagaggtgct agaccatcga cccatcgagc cgaaacactg    540

ccctccctgc catgtttcag ttgagctggt ggggtcctgt gctaccctgg tgaccgagag    600

aatcctgcag ggggcaccag agatcttgga caggcaaact gcagcccttc tgcatggaac    660

catcatcctg gactgtgtca acatggacct taaaattgga aaggcaaccc caaaggacag    720

caaatatgtg gagaaactag aggccctttt cccagaccta cccaagagaa atgatatatt    780

tgattcccta caaaaggcaa agtttgatgt atcaggactg accactgagc agatgctgag    840

aaaagaccag aagactatct atagacaagg cgtcaaggtg gccattagtg caatatatat    900

ggatttggag gcctttctgc agaggtctaa cctccttgca gatctccatg ctttctgcca    960

ggctcacagc tatgatgtcc tggttgccat gactatcttt ttcaacactc acaatgagcc   1020

agtgcggcag ttggctattt tctgtcccca tgtggcactc caaacaacga tctgtgaagt   1080

cctggaacgc tcccactctc cacccctgaa gctgacccct gcctcaagta cccaccctaa   1140

cctccatgcc tatcttcaag gcaacaccca ggtctctcga aagaaacttc tgcccctgct   1200

ccaggaagcc ctgtcagcat attttgactc catgaagatc ccttcaggac agcctgagac   1260

agcagatgtg tccagggagc aagtggacaa ggaattggac agggcaagta actccctgat   1320

ttctggactg agtcaagatg aggaggaccc tccgctgccc ccgacgccca tgaacagctt   1380

ggtggatgag tgccctctag atcaggggct gcctaaactc tctgctgagg ccgtcttcga   1440

gaagtgcagt cagatctcac tgtcacagtc taccacagcc tccctgtcca agaagtgact   1500

gttgagaggc gaggaggtag tgggtgaggc tacctgactc acttcaaatg catgttttga   1560

gatgtttgga gattcagcaa ttctgtcttc attgctccag gatctggtat actgttctca   1620

taaaactgag aggagaaaaa aagtgaaaga aagcagctgc tttaagaatg gttttccacc   1680

ttttccccct aatctctacc aatcagacac attttattat ttaaatctgc acctctctct   1740

attttatttg ccaggggcac gatgtgacat atctgcagtc ccagcacagt gggacaaaaa   1800

gaatttagac cccaaaagtg tcctcggcat ggatcttgaa cagaaccagt atctgtcatg   1860

gaactgaaca ttcatcgatg gtctccatgt attcatttat tcacttgttc attcaagtat   1920

ttattgaata cctgcctcaa gctagagaga aaagagagtg cgctttggaa atttattcca   1980

gttttcagcc tacagcagat tatcagctcg gtgacttttc tttctgccac catttaggtg   2040

atggtgtttg attcagagat ggctgaattt ctattcttag cttattgtga ctgtttcaga   2100

tctagtttgg gaacagatta gaggccattg tcttctgtcc tgatcaggtg gcctggctgt   2160

ttctttggat ccctctgtcc cagagccacc cagaaccctg actcttgaga atcaagaaaa   2220

cacccagaaa ggccttaatg acctcatagg cactcttcca aaaagacaac agaactggaa   2280

tgagaggcct gggtctgtct cctgccttag caggcctatc aatttcttgt caatctcttt   2340

ttttccttgc tcacattaaa aggaagcatg gagttctaat gctcccataa actatgtatt   2400

ttggcaagac acttcactac tccaggtctc actttcccca tctgtaaaac agggtttgga   2460

ctaggtgttc cctggtattc tgtgatctgc ctcttgctgc cattctttct ctcctctgct   2520

tctctgtatt tttcttctgt tatccctggg ggtgctcagg ttcacttgat tgtctgtatt   2580

tctgtgtggt tgtagcaagg actcagcctc atgtagcacg aataggggtg tggttcatgg   2640

cgtgttgacc cagcagagca ctccctccca ctaacttgtt ctgcatgtgt agagtctccc   2700

catttttttt aacgcaaccc tttccccttt ttcctacccc acagctctgt tccatgtaag   2760

ttgccaacag tttcactgaa cagtggggta tgtgatggtt ttggcatgac atcttcagta   2820

tgagggggac agtttgactt cactttgagg gtgtgatgtc tgtagctatg tggaaggtaa   2880

aaatagtggt gtgatcatga accaaaggaa tttatgtttt gtaacttggg tactttattt   2940

tgcattttgt tatactatta aataattttt tcctgttaaa aaaaaaaaaa aaaaa        2995


<210>  656
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  656

Met Glu Asp Tyr Leu Gln Gly Cys Arg Ala Ala Leu Gln Glu Ser Arg 
1               5                   10                  15      


Pro Leu His Val Val Leu Gly Asn Glu Ala Cys Asp Leu Asp Ser Thr 
            20                  25                  30          


Val Ser Ala Leu Ala Leu Ala Phe Tyr Leu Ala Lys Thr Thr Glu Ala 
        35                  40                  45              


Glu Glu Val Phe Val Pro Val Leu Asn Ile Lys Arg Ser Glu Leu Pro 
    50                  55                  60                  


Leu Arg Gly Asp Ile Val Phe Phe Leu Gln Lys Val His Ile Pro Glu 
65                  70                  75                  80  


Ser Ile Leu Ile Phe Arg Asp Glu Ile Asp Leu His Ala Leu Tyr Gln 
                85                  90                  95      


Ala Gly Gln Leu Thr Leu Ile Leu Val Asp His His Ile Leu Ser Lys 
            100                 105                 110         


Ser Asp Thr Ala Leu Glu Glu Ala Val Ala Glu Val Leu Asp His Arg 
        115                 120                 125             


Pro Ile Glu Pro Lys His Cys Pro Pro Cys His Val Ser Val Glu Leu 
    130                 135                 140                 


Val Gly Ser Cys Ala Thr Leu Val Thr Glu Arg Ile Leu Gln Gly Ala 
145                 150                 155                 160 


Pro Glu Ile Leu Asp Arg Gln Thr Ala Ala Leu Leu His Gly Thr Ile 
                165                 170                 175     


Ile Leu Asp Cys Val Asn Met Asp Leu Lys Ile Gly Lys Ala Thr Pro 
            180                 185                 190         


Lys Asp Ser Lys Tyr Val Glu Lys Leu Glu Ala Leu Phe Pro Asp Leu 
        195                 200                 205             


Pro Lys Arg Asn Asp Ile Phe Asp Ser Leu Gln Lys Ala Lys Phe Asp 
    210                 215                 220                 


Val Ser Gly Leu Thr Thr Glu Gln Met Leu Arg Lys Asp Gln Lys Thr 
225                 230                 235                 240 


Ile Tyr Arg Gln Gly Val Lys Val Ala Ile Ser Ala Ile Tyr Met Asp 
                245                 250                 255     


Leu Glu Ala Phe Leu Gln Arg Ser Asn Leu Leu Ala Asp Leu His Ala 
            260                 265                 270         


Phe Cys Gln Ala His Ser Tyr Asp Val Leu Val Ala Met Thr Ile Phe 
        275                 280                 285             


Phe Asn Thr His Asn Glu Pro Val Arg Gln Leu Ala Ile Phe Cys Pro 
    290                 295                 300                 


His Val Ala Leu Gln Thr Thr Ile Cys Glu Val Leu Glu Arg Ser His 
305                 310                 315                 320 


Ser Pro Pro Leu Lys Leu Thr Pro Ala Ser Ser Thr His Pro Asn Leu 
                325                 330                 335     


His Ala Tyr Leu Gln Gly Asn Thr Gln Val Ser Arg Lys Lys Leu Leu 
            340                 345                 350         


Pro Leu Leu Gln Glu Ala Leu Ser Ala Tyr Phe Asp Ser Met Lys Ile 
        355                 360                 365             


Pro Ser Gly Gln Pro Glu Thr Ala Asp Val Ser Arg Glu Gln Val Asp 
    370                 375                 380                 


Lys Glu Leu Asp Arg Ala Ser Asn Ser Leu Ile Ser Gly Leu Ser Gln 
385                 390                 395                 400 


Asp Glu Glu Asp Pro Pro Leu Pro Pro Thr Pro Met Asn Ser Leu Val 
                405                 410                 415     


Asp Glu Cys Pro Leu Asp Gln Gly Leu Pro Lys Leu Ser Ala Glu Ala 
            420                 425                 430         


Val Phe Glu Lys Cys Ser Gln Ile Ser Leu Ser Gln Ser Thr Thr Ala 
        435                 440                 445             


Ser Leu Ser Lys Lys 
    450             


<210>  657
<211>  2360
<212>  DNA
<213>  Homosapiens

<400>  657
acgcggggga gctacaacag ctgagacaga aaagaggtaa ggaagtgttg ggggctggga     60

caaccagctc cccgacaact cctaggtgtt taaagaagga ggcaggaaga cttgtgaaga    120

tgggaactat acaagaggca ggaaaaaaga cagatgttgg gtggagcaac tgctacagag    180

gtaaatatga ttaactttac attccatctt tcgtctgctc ccaaacttaa cagcaggtaa    240

tctgcttcta gcaagtggtg aaggtaagag aagcatctgt ataggaggca agagatctga    300

gtccttttga aggcctatcc tctgctctgt atctcaatta ctgttcttca tttcaattat    360

tcttacctac tattcagttc ccttgatctt ttcttcttgg gggctgtctt agggtcaggg    420

agattgcaga agcaccagaa ctaggagcag ccctgagaca tggggagttg gagctgaagg    480

aggaatggca ggatgaagaa ttccctagat tgcttcctga ggaggctggc acttctgaag    540

atcctgaaga ccctaaagga gattcacagg cagctgcagg tacccccagc actttagccc    600

tgtgtggcca gcgccccatg cgcaagcgtc tttctgcccc agagttgcgg ctgagtctga    660

ctaaggggcc tggaaatgat ggagcttcac ccacccagtc tgcaccttcc tctcctgatg    720

gcagttctga cctggagata gacgaattgg agacaccttc agactcggag cagctggaca    780

gtggacatga atttgaatgg gaagatgaac taccccgggc agagggtctg ggcaccagtg    840

agacagctga aaggctgggc cgaggttgta tgtgggatgt gactggagaa gatggacatc    900

actggagggt gttccgaatg ggaccacggg agcagcgcgt agacatgact gtcattgagc    960

cctataagaa agtcctgtct catggaggtt accacggtga tggcctcaat gctgtcatcc   1020

tttttgcttc ctgttatcta cccagaagca gcatccccaa ctacacctat gtcatggaac   1080

acttgtttag gtatatggtg ggaactctgg agctgctagt agctgaaaat tacctgcttg   1140

ttcatttgag tggaggcaca agcagggccc aagttccacc tctaagctgg atacgtcagt   1200

gttaccgtac cctggatcgg cggctacgga aaaacctgcg agccctggtg gttgtccatg   1260

ctacatggta tgtgaaagca tttctggcac tgcttcggcc cttcatcagt tccaaattca   1320

cacgaaaaat ccgttttctg gacagcctgg gggagctggc ccaactcata tccctggatc   1380

aagtccacat ccctgaagct gtcagacagc tggaccggga tctccatggc tcaggaggga   1440

catagcacag gactggataa agggccttag aaccagttag tgatctgcct acacctgaat   1500

ccctgaaaca tctgaactgt tttgtaaatc atcttatccc caacctcagt accaccggat   1560

cttcacttct cagtgggatt ttgtcctttg catgacccta ctttcagcag ggctttgagg   1620

ctgggaaact gatctgctgg gtgactttca ttccagttgc tgggacggaa ggctgaatgt   1680

agggtcattt tgtatgggat atgcagagct ctgggttttt ttgttttttg ttttttgaga   1740

cggagtctcg ctctgtcgcc aggctggagt gcagtggtgc gatctcggct cactgcaacc   1800

tccgcctccc ggttcaagcc attcttctgc ctcagcctca gcgagtagct gagactaccg   1860

gcgcacgcca ccacgcccag ctaattgttt tgtattttta gtagagacgg ggtttcacca   1920

tgttggccag gatggtctcg atctcttgac ctcgtgatct gcccgcctcg gcctcccaaa   1980

gtgccgagat tacaggtgtg agccaccgcg ctcggccaga gctctgggtt ttaatcctac   2040

tttagctgta gaaccttggg caaataactt catctttttg ggtcctaatt ttcctcctgt   2100

ctaactggag ggactgtgat ccttccacct tggatggaag aggcttacct gacagccagc   2160

ctgcctgctg ggagccagga gagtcagctc attaaatctt gaagaaccgc tgtatgccct   2220

ttttccttct aagtcatgtc tgctgcctgt gagcctggga aggagtgctt tcaaaacctg   2280

tatttttgcc ctctttagta aatttagaac tgtagaggct aataaactgc gatgagacat   2340

ttaaaaaaaa aaaaaaaaaa                                               2360


<210>  658
<211>  275
<212>  PRT
<213>  Homosapiens

<400>  658

Met Arg Lys Arg Leu Ser Ala Pro Glu Leu Arg Leu Ser Leu Thr Lys 
1               5                   10                  15      


Gly Pro Gly Asn Asp Gly Ala Ser Pro Thr Gln Ser Ala Pro Ser Ser 
            20                  25                  30          


Pro Asp Gly Ser Ser Asp Leu Glu Ile Asp Glu Leu Glu Thr Pro Ser 
        35                  40                  45              


Asp Ser Glu Gln Leu Asp Ser Gly His Glu Phe Glu Trp Glu Asp Glu 
    50                  55                  60                  


Leu Pro Arg Ala Glu Gly Leu Gly Thr Ser Glu Thr Ala Glu Arg Leu 
65                  70                  75                  80  


Gly Arg Gly Cys Met Trp Asp Val Thr Gly Glu Asp Gly His His Trp 
                85                  90                  95      


Arg Val Phe Arg Met Gly Pro Arg Glu Gln Arg Val Asp Met Thr Val 
            100                 105                 110         


Ile Glu Pro Tyr Lys Lys Val Leu Ser His Gly Gly Tyr His Gly Asp 
        115                 120                 125             


Gly Leu Asn Ala Val Ile Leu Phe Ala Ser Cys Tyr Leu Pro Arg Ser 
    130                 135                 140                 


Ser Ile Pro Asn Tyr Thr Tyr Val Met Glu His Leu Phe Arg Tyr Met 
145                 150                 155                 160 


Val Gly Thr Leu Glu Leu Leu Val Ala Glu Asn Tyr Leu Leu Val His 
                165                 170                 175     


Leu Ser Gly Gly Thr Ser Arg Ala Gln Val Pro Pro Leu Ser Trp Ile 
            180                 185                 190         


Arg Gln Cys Tyr Arg Thr Leu Asp Arg Arg Leu Arg Lys Asn Leu Arg 
        195                 200                 205             


Ala Leu Val Val Val His Ala Thr Trp Tyr Val Lys Ala Phe Leu Ala 
    210                 215                 220                 


Leu Leu Arg Pro Phe Ile Ser Ser Lys Phe Thr Arg Lys Ile Arg Phe 
225                 230                 235                 240 


Leu Asp Ser Leu Gly Glu Leu Ala Gln Leu Ile Ser Leu Asp Gln Val 
                245                 250                 255     


His Ile Pro Glu Ala Val Arg Gln Leu Asp Arg Asp Leu His Gly Ser 
            260                 265                 270         


Gly Gly Thr 
        275 


<210>  659
<211>  982
<212>  DNA
<213>  Homosapiens

<400>  659
atgcgcaagc gtctttctgc cccagagttg cggctgagtc tgactaaggg gcctggaaat     60

gatggagctt cacccaccca gtctgcacct tcctctcctg atggcagttc tgacctggag    120

atagacgaat tggagacacc ttcagactcg gagcagctgg acagtggaca tgaatttgaa    180

tgggaagatg aactaccccg ggcagagggt ctgggcacca gtgagacagc tgaaaggctg    240

ggccgaggtt gtatgtggga tgtgactgga gaagatggac atcactggag ggtgttccga    300

atgggaccac gggagcagcg cgtagacatg actgtcattg agccctataa gaaagtcctg    360

tctcatggag gttaccacgg tgatggcctc aatgctgtca tcctttttgc ttcctgttat    420

ctacccagaa gcagcatccc caactacacc tatgtcatgg aacacttgtt taggtatatg    480

gtgggaactc tggagctgct agtagctgaa aattacctgc ttgttcattt gagtggaggc    540

acaagcaggg cccaagttcc acctctaagc tggatacgtc agtgttaccg taccctggat    600

cggcgagttt tataagtaat cttggtcatg gagcgatgta gaagcatgca aaaggaactt    660

acgcgagggt agagcacaag atggaaatgg agcagaaaaa gaccaggtgg tcgggcgcgg    720

tggctcacgt ctgtaatccc agcactttgg aaggccgagg ctacggaaaa acctgcgagc    780

cctggtggtt gtccatgcta catggtatgt gaaagcattt ctggcactgc ttcggccctt    840

catcagttcc aaattcacac gaaaaatccg ttttctggac agcctggggg agctggccca    900

actcatatcc ctggatcaag tccacatccc tgaagctgtc agacagctgg accgggatct    960

ccatggctca ggagggacat ag                                             982


<210>  660
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  660

Met Arg Lys Arg Leu Ser Ala Pro Glu Leu Arg Leu Ser Leu Thr Lys 
1               5                   10                  15      


Gly Pro Gly Asn Asp Gly Ala Ser Pro Thr Gln Ser Ala Pro Ser Ser 
            20                  25                  30          


Pro Asp Gly Ser Ser Asp Leu Glu Ile Asp Glu Leu Glu Thr Pro Ser 
        35                  40                  45              


Asp Ser Glu Gln Leu Asp Ser Gly His Glu Phe Glu Trp Glu Asp Glu 
    50                  55                  60                  


Leu Pro Arg Ala Glu Gly Leu Gly Thr Ser Glu Thr Ala Glu Arg Leu 
65                  70                  75                  80  


Gly Arg Gly Cys Met Trp Asp Val Thr Gly Glu Asp Gly His His Trp 
                85                  90                  95      


Arg Val Phe Arg Met Gly Pro Arg Glu Gln Arg Val Asp Met Thr Val 
            100                 105                 110         


Ile Glu Pro Tyr Lys Lys Val Leu Ser His Gly Gly Tyr His Gly Asp 
        115                 120                 125             


Gly Leu Asn Ala Val Ile Leu Phe Ala Ser Cys Tyr Leu Pro Arg Ser 
    130                 135                 140                 


Ser Ile Pro Asn Tyr Thr Tyr Val Met Glu His Leu Phe Arg Tyr Met 
145                 150                 155                 160 


Val Gly Thr Leu Glu Leu Leu Val Ala Glu Asn Tyr Leu Leu Val His 
                165                 170                 175     


Leu Ser Gly Gly Thr Ser Arg Ala Gln Val Pro Pro Leu Ser Trp Ile 
            180                 185                 190         


Arg Gln Cys Tyr Arg Thr Leu Asp Arg Arg Val Leu 
        195                 200                 


<210>  661
<211>  2055
<212>  DNA
<213>  Homosapiens

<400>  661
ggagcgaagg taggaggcag ggcttgcctc actggccacc ctcccaaccc caagagccca     60

gccccatggt ccccgccgcc ggcgcgctgc tgtgggtcct gctgctgaat ctgggtcccc    120

gggcggcggg ggcccaaggc ctgacccaga ctccgaccga aatgcagcgg gtcagtttac    180

gctttggggg ccccatgacc cgcagctacc ggagcaccgc ccggactggt cttccccgga    240

agacaaggat aatcctagag gacgagaatg atgccatggc cgacgccgac cgcctggctg    300

gaccagcggc tgccgagctc ttggccgcca cggtgtccac cggctttagc cggtcgtccg    360

ccattaacga ggaggatggg tcttcagaag agggggttgt gattaatgcc ggaaaggata    420

gcaccagcag agagcttccc agtgcgactc ccaatacagc ggggagttcc agcacgaggt    480

ttatagccaa tagtcaggag cctgaaatca ggctgacttc aagcctgccg cgctcccccg    540

ggaggtctac tgaggacctg ccaggctcgc aggccaccct gagccagtgg tccacacctg    600

ggtctacccc gagccggtgg ccgtcaccct cacccacagc catgccatct cctgaggatc    660

tgcggctggt gctgatgccc tggggcccgt ggcactgcca ctgcaagtcg ggcaccatga    720

gccggagccg gtctgggaag ctgcacggcc tttccgggcg ccttcgagtt ggggcgctga    780

gccagctccg cacggagcac aagccttgca cctatcaaca atgtccctgc aaccgacttc    840

gggaagagtg ccccctggac acaagtctct gtactgacac caactgtgcc tctcagagca    900

ccaccagtac caggaccacc actaccccct tccccaccat ccacctcaga agcagtccca    960

gcctgccacc cgccagcccc tgcccagccc tggctttttg gaaacgggtc aggattggcc   1020

tggaggatat ttggaatagc ctctcttcag tgttcacaga gatgcaacca atagacagaa   1080

accagaggta atggccactt catccacatg aggagatgtc agtatctcaa cctctcttgc   1140

cctttcaatc ctagcaccca ctagatattt ttagtacaga aaaacaaaac tggaaaacac   1200

attgtttggt cttgtgtttc tttacagagg tacctgaggg aggagagaca taaatccctt   1260

catccctaag actgaactat gtaactagca gcctctggct tgttttctac tccctgtccc   1320

tcaggataaa atgttgatat tgctcatttt cctcatttcc aacattgttt taaaacaagt   1380

acttctttta caggcttgaa aaatctcaaa taaacgctaa gaaaagggag taggaagaac   1440

aaggagttga gcccttgaaa gatgacagtg gtcttcttgc cttcatgctt ggccctctct   1500

cctcaaaagg gcaatgttgg tacaaaattc catctcagcc actttcgagg agttatcttc   1560

attagctata tccatccttt aatccaacac acacctgcaa tgattactgt gcaactattt   1620

tgcttaattt tttatttgaa aaaatgtatt taaaagtcca acaacttttt aatataaatt   1680

acgactctca aacccattcc catcacttta ttagtgatgg tagcatacat attagagaag   1740

gtagctaaag gcaagagagc accaaaggaa aaagactgtc caaagaacag gtattagaat   1800

gaggccgaag atcacggtga ccagagattt ctaggagtct ctaacctttc caccctatcc   1860

tgttaaccct ttagatctct agtataacac tcaggctact gaggtatttt agagcaacaa   1920

gctgggttac tttcagagca accagcttga ctggaactga gagtaaattg ggaatgtatg   1980

accaatctta gaccctgaaa aatggcagaa aatacatgga aatttgaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaa                                                    2055


<210>  662
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  662

Met Val Pro Ala Ala Gly Ala Leu Leu Trp Val Leu Leu Leu Asn Leu 
1               5                   10                  15      


Gly Pro Arg Ala Ala Gly Ala Gln Gly Leu Thr Gln Thr Pro Thr Glu 
            20                  25                  30          


Met Gln Arg Val Ser Leu Arg Phe Gly Gly Pro Met Thr Arg Ser Tyr 
        35                  40                  45              


Arg Ser Thr Ala Arg Thr Gly Leu Pro Arg Lys Thr Arg Ile Ile Leu 
    50                  55                  60                  


Glu Asp Glu Asn Asp Ala Met Ala Asp Ala Asp Arg Leu Ala Gly Pro 
65                  70                  75                  80  


Ala Ala Ala Glu Leu Leu Ala Ala Thr Val Ser Thr Gly Phe Ser Arg 
                85                  90                  95      


Ser Ser Ala Ile Asn Glu Glu Asp Gly Ser Ser Glu Glu Gly Val Val 
            100                 105                 110         


Ile Asn Ala Gly Lys Asp Ser Thr Ser Arg Glu Leu Pro Ser Ala Thr 
        115                 120                 125             


Pro Asn Thr Ala Gly Ser Ser Ser Thr Arg Phe Ile Ala Asn Ser Gln 
    130                 135                 140                 


Glu Pro Glu Ile Arg Leu Thr Ser Ser Leu Pro Arg Ser Pro Gly Arg 
145                 150                 155                 160 


Ser Thr Glu Asp Leu Pro Gly Ser Gln Ala Thr Leu Ser Gln Trp Ser 
                165                 170                 175     


Thr Pro Gly Ser Thr Pro Ser Arg Trp Pro Ser Pro Ser Pro Thr Ala 
            180                 185                 190         


Met Pro Ser Pro Glu Asp Leu Arg Leu Val Leu Met Pro Trp Gly Pro 
        195                 200                 205             


Trp His Cys His Cys Lys Ser Gly Thr Met Ser Arg Ser Arg Ser Gly 
    210                 215                 220                 


Lys Leu His Gly Leu Ser Gly Arg Leu Arg Val Gly Ala Leu Ser Gln 
225                 230                 235                 240 


Leu Arg Thr Glu His Lys Pro Cys Thr Tyr Gln Gln Cys Pro Cys Asn 
                245                 250                 255     


Arg Leu Arg Glu Glu Cys Pro Leu Asp Thr Ser Leu Cys Thr Asp Thr 
            260                 265                 270         


Asn Cys Ala Ser Gln Ser Thr Thr Ser Thr Arg Thr Thr Thr Thr Pro 
        275                 280                 285             


Phe Pro Thr Ile His Leu Arg Ser Ser Pro Ser Leu Pro Pro Ala Ser 
    290                 295                 300                 


Pro Cys Pro Ala Leu Ala Phe Trp Lys Arg Val Arg Ile Gly Leu Glu 
305                 310                 315                 320 


Asp Ile Trp Asn Ser Leu Ser Ser Val Phe Thr Glu Met Gln Pro Ile 
                325                 330                 335     


Asp Arg Asn Gln Arg 
            340     


<210>  663
<211>  3009
<212>  DNA
<213>  Homosapiens

<400>  663
cagagctagc ccgggaagcc cacactggcg gccacggagc agagtccctc acccccacca     60

gctgtagctg aacgtctgga tggtggagaa gagcagggtt ccgagtctga ggaagacata    120

accttgtgcc tgcctgccca cctctctctc tggtcctgtt catctctcag gctctgagac    180

actgaccttc actgctcagt taaaggttcc agggattcca ctttgtctgg acccatccag    240

ctgagtgaac ccagggtggt ggtgtatctg gggagagtga ggagtgggtt gtccaaacac    300

cagggaaaga gccctttggg gcctcagaca gaggagtgaa gctggaacca tcagggaaca    360

tgagtgaatt ttggcacaaa ctgggctgct gtgtggtaga gaaaccccag ccgaagaaga    420

agagaagacg gattgaccgg accatgattg gggaaccaat gaattttgtt cacctgactc    480

acattggctc aggggagatg ggggccggag atggacttgc catgacaggt gcagttcagg    540

agcagatgag atccaaggga aaccgagata ggccatggag caattctagg ggcttatagc    600

tccaataatg gaatggttct gccatcttga aacccccatt ctgtttccag cccagaagaa    660

atgctgcccc taccagatcc ctccttgaac cagtgatcta aggacccctc ttttccctat    720

ctgcctaaca gtgcctcaca aggcttgggg gctggactcc ctctactccc tctggccata    780

gcccctcctg gagatggggt caaggcagca ggactgatca agtgactact ggttagccag    840

agggagcgct gaagcctagg aaaccctcag gtctgagata ggagttctct aggaacctgg    900

aatgagttcc tgtctcctga atgatggtct gggtgccacc tgtttttaaa ctcttaaacc    960

tggaactcct taaatggggt aggtgggtga gattatcaaa gctgaagctg gctttgctga   1020

gaagctccct acctccctgc ccttctcctc cttcctggct gggaatgaac taaagcagat   1080

gtctaagcag gggctggggg ggtgcctact cccttttcca ctctatcttt agatttcaaa   1140

ccttaggctt acagccctca atatctctct gctaacacca gtgtctcttt ctagttaggc   1200

ctctaatctt ctgtttctgt ttaccagctt cccagcaact ttcctttttt aaaatattaa   1260

aaatttaatt caggttctct taattatcct catcctgctg ttcctccgcc cttaactcta   1320

tccctattag gaaccttgtt tcccaccgaa taagagttaa ggtaagaggt agctcttcac   1380

ctgatgacat tccatttaag ttttggggca tctttcctgc cctctgccaa cctccctgct   1440

ggcccaggtg agaggaggaa gaggggtctg gaaagaaacc cagaatgcgg cagaactagg   1500

agtaagtcca tctcaaggtg gacttctgat cattgaggat ggtgagataa ataggttgaa   1560

aacaatcatc tgtgagttta ggagtcttaa gatcctcaca gcacgggagc agggagaggc   1620

tctagaacaa ggtttcacaa ccgagatgcc tttgacattt tgggctgaag tgttctttgt   1680

aaggaaaacc tgtttcctat tttgtgcatt acaggatatt tagcagcacg cctggcccac   1740

tctagttatg acaaccaaaa atgtctctat acattgccag atttctccta gggggcaaaa   1800

tcgcctccat ttgagactac aactctgagt tccgtagggg gcaaaatcgc ctccatttga   1860

gaaccacaac tctaaagtca agatattttt ctctgaagtg atttctgctt ggcacgctac   1920

cctcatcatc ttactcatct taagcccgag catggatcaa ctaggagccc atataaatga   1980

ggctcagtag ggctgacata atctccaaac aattctttaa ttcagtgtat tgcttggtgt   2040

ttgcatgttg ctatgattgg aacaaggttc cccctcctcc attcttgccc tctggagaag   2100

tggttcctgc agtgtagaga tatgaacagg gtatggtagg attggggaaa ggggagagag   2160

aagcagtaga tacactcctt atcctcccca aattttaagc tctatttttg tgccctagtc   2220

ctagacacac attagactca gggagttttg tctgaagacc aggtcccact gccccctggc   2280

tgaagagtct gctttaaatg ggaaaacaac gtaggagcag gggtttttag gcactttcag   2340

ttttctcagg tgttcttcgt tctggccctt ccagggtaat taggaaggca gaacaagaca   2400

gatgagctcc tgcctgctct gagacaagaa gggtggggtc tcattagctt tgcaacagga   2460

aacatcctgt tttattatgg tagtggggtc aggaatgtag gaactggtat ccattctgcc   2520

aattcccacc cattcagttt gcttatccct acagaacagt gactgaggtt cctttttttt   2580

tttttttttt tttttttttc aaatttccat gtattttctg ccatttttca gggtctaaga   2640

ttggtcatac attcccaatt tactctcagt tccagtcaag ctggttgctc tgaaagtaac   2700

ccagcttgtt gctctaaaat acctcagtag cctgagtgtt atactagaga tctaaagggt   2760

taacaggata gggtggaaag gttagagact cctagaaatc tctggtcacc gtgatcttcg   2820

gcctcattct aatacctgtt ctttggacag tctttttcct ttggtgctct cttgccttta   2880

gctaccttct ctaatatgta tgctaccatc actaataaag tgatgggaat gggtttgaga   2940

gtcgtaattt atattaaaaa gttgttggac ttttaaatac attttttcaa ataaaaaatt   3000

aagcaaaat                                                           3009


<210>  664
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  664

Met Ser Glu Phe Trp His Lys Leu Gly Cys Cys Val Val Glu Lys Pro 
1               5                   10                  15      


Gln Pro Lys Lys Lys Arg Arg Arg Ile Asp Arg Thr Met Ile Gly Glu 
            20                  25                  30          


Pro Met Asn Phe Val His Leu Thr His Ile Gly Ser Gly Glu Met Gly 
        35                  40                  45              


Ala Gly Asp Gly Leu Ala Met Thr Gly Ala Val Gln Glu Gln Met Arg 
    50                  55                  60                  


Ser Lys Gly Asn Arg Asp Arg Pro Trp Ser Asn Ser Arg Gly Leu 
65                  70                  75                  


<210>  665
<211>  1715
<212>  DNA
<213>  Homosapiens

<400>  665
gaaccaaccg gttgcttgct gtcccagcgg cgccccctca tcaccgtcgc catgcccgga     60

ggtctgcttc tcggggacgt ggctcccaac tttgaggcca ataccaccgt cggccgcatc    120

cgtttccacg actttctggg agactcatgg ggcattctct tctcccaccc tcgggacttt    180

accccagtgt gcaccacaga gcttggcaga gctgcaaagc tggcaccaga atttgccaag    240

aggaatgtta agttgattgc cctttcaata gacagtgttg aggaccatct tgcctggagc    300

aaggatatca atgcttacaa ttgtgaagag cccacagaaa agttaccttt tcccatcatc    360

gatgatagga atcgggagct tgccatcctg ttgggcatgc tggatccagc agagaaggat    420

gaaaagggca tgcctgtgac agctcgtgtg gtgtttgttt ttggtcctga taagaagctg    480

aagctgtcta tcctctaccc agctaccact ggcaggaact ttgatgagat tctcagggta    540

gtcatctctc tccagctgac agcagaaaaa agggttgcca ccccagttga ttggaaggat    600

ggggatagtg tgatggtcct tccaaccatc cctgaagaag aagccaaaaa acttttcccg    660

aaaggagtct tcaccaaaga gctcccatct ggcaagaaat acctccgcta cacaccccag    720

ccttaagtct cttggagaag ctggtgctgt gagccagagg atgtcagctg ccaattgtgt    780

tttcctgcag caattccata aacacatcct ggtgtcatca cagccaaggt ttttaggttg    840

ctataccaat ggcttattaa atgaaaatgg cactaaaagt ttcttgagat tctttatact    900

ctctgccttc agcaatcaat tccattcata catcagcact ctgctggttc tgtttgaaat    960

atgttctgta tttaaaactc aaatcttgtt ggatctctgc agggcttgtg accaatgaag   1020

tcatatttgt tgatggttga caaagcttgc ttcactccat cagagaatga ctatcaattt   1080

ttttttaact gtcctatcac gtcctctcct gtcacccatt ttgaagagtg gcagaacttg   1140

aagttcaact tcctctgtaa atatccaagt ataaagccca ggaacttcta gaataaccca   1200

gatgcgcttt aatttttttt aatatgtttt gatcacagaa cttctagaat aacccagatg   1260

ctctttcata ttcttttaat acatcttgat cacagctggg ggaaaaaaag ctttttaatt   1320

ctataccttc ctagtagata agtgaagagc agggaaagag acctttaaat attttgctat   1380

aaaaaaattt gtgataagtt tctatcaaaa tggggagatt gcagaaaagg cttcccttgg   1440

ctcccaagga ggtgtagcag gtgtgagcaa tattagtgcc atgtgccttt cacacagggt   1500

ttgcatttat cagtctgttt tccgatgatg tgtacatgaa agagtacacc atgtgaagag   1560

aagagagaat gattgaaaat gttttagtat agaactcttc ttgcagtggg ttgctatttt   1620

ctagatttta ctttttaggg aacaaaataa aatcctttgt taaaactggg aaaaaaaaaa   1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                              1715


<210>  666
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  666

Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  667
<211>  4424
<212>  DNA
<213>  Homosapiens

<400>  667
cataactgtg cattgttctt tgggattttg agagccttca tctcaatttc aactttaaag     60

cagcttaatc tttaaggaac atatctctga tctgggtaat ttgtagaact taatttgagg    120

gtcattacat gtgaggatag caggagttga agatgccaag gacctgaagg gctactggag    180

ggacaggtga agtgatttga agatgtagca ttttgaatct ctttctggcc catcctctgc    240

ttcacaccag aatcattgtg acctgtagac ctgcaaaaca aaggaccaaa ggttagcatg    300

cagaagtgaa agtgtcaata ataaccaaac cactccatca agttaggtct ggggaaaagc    360

agcagcaaaa atgagttctt acttctgggc acaaaatgaa agtaacagac ctgatttact    420

ctgcgggcag ccagctgact accttgttga agagaaacat ttcacaacgc ttgtatgctt    480

cattgttgtt ttgggagggc ttttgaagat gtgtttaaag aattgtgaag tcattgtttt    540

gacgattctt tctctatcag gattcgtgat aggacacatg gcctacaatt ctgttgaggt    600

gcaccaaatt gtctaccctc ttctaagaac atcaagtttt tcactttatt cttacttttc    660

acctttaatt atatttatgg ttgctttgga tgtagaattt tatacactca agaaaatgtt    720

ttggcaggtc ttgttaactg gattaattag cttttctaca gcaagcatca taattggata    780

tgtcgttata aaattcaata aagattcatg ggatttgcaa tcttgcctac tctttagcat    840

cacccttggc attatagatc ctcttcgttc tgtgaattca ctaaaaacta ttggcatttc    900

taaaatatac attgatctca ttagaggaga atcattgatc atttgtagca tcgcatcaat    960

tttttttgga aattttcggg gcaacagaat ccacttttct atttttagag atttacatgt   1020

aggcattgaa ctcagctatg acattttggg aagcataata tttggatatt ggtgtgcaaa   1080

aatcattcag tgtatattgg ctgacgtttt tagcaatatg ctgactaata tcattctctg   1140

cttttcaatg gtgtacatga ctttctatat tgtggaattt ttaggaatgt caggcactct   1200

tgccttagcc gctgtaggac tgaatttaga ttctttaact tttaaaccga agatcgaact   1260

tgtaattact aagttcttaa gaattttttc atctgtatat gaacatttaa tatatgcttt   1320

ctttggcatt gtgattggat gtggagaact cagccactat gaatttcaca ctataccttt   1380

catattcatt ttatttacaa cagtgaattt ggtaaggttg cttactattt tgttagtgag   1440

ccctattttg atgcattcaa attatgaata taattggcga tggggagttg taatcacgtg   1500

gtctggaatt aaaggagttt ttaatttact ctgggctcct gatgtttata atctcgctga   1560

acgaaaagtg gaagtaccac aaatgtttat actctatgta caagtaatat cattattgac   1620

aatgggaata aattcatacg tgatgactca gtcagccagg aagttagatt tgtgtgttct   1680

ttccctccca agacaaatga tcttgcaaaa tgccactcag cacatacagg agatagtaca   1740

gaacacaata actttattta aaacagaaaa aattttgaca aatgttaact ggaccttagt   1800

agaagataaa acgaggatcg aatacattcc tttttcccac gtttcacata atgatatgaa   1860

gacagaatcc acaacagatg aagctttaat ggaggaagcc agattgcatg tagctgcaat   1920

acaaatgagt agctttgaaa aacagcgtaa caatggaatt cttgaaatag aggcagcccg   1980

gatattaatt ggtgcagcaa aatgctatta ctccatccaa ggaaaattca tgagtattta   2040

tgatgtttca acttatatga gaactagaag ttggcttata aagtttaaaa atgttttaac   2100

tttcttggaa tattgtatag aaaagataca ttttattcca cctgagagta atacatttct   2160

gacttttata tttcacatag tattttctga agaatttgaa tatacaggac agattataaa   2220

tttgatatat atttatccta tgataataca tctgtggcca atggcaagag gtttaaatgt   2280

atcagcactg atatcaataa actactattt tatgttttta tatgtattag aatcaacatt   2340

gaagataata attttgaaaa ggaaatattt tcaacaatgt tggaatactt tggaattttt   2400

tatcctggtt attggaatca ttgatatctt ttgtgtatac tttgtgaaat tgagaccaga   2460

caacttggct cttatacagc ttacagtaat aatgggatat ttaagaataa ttaggtttct   2520

tcctctcttc aagataatag taccaatact gataagaatt gcagatgtgc agatcaaaaa   2580

gcgcctcagc ttgatgtata gtattacaaa aggctatatc aaaagtcaag aagatgccaa   2640

acttctaata aaacaaatag ctgtctgtga atcaatatat cagaaactat gtgaaatttt   2700

ggaaaccaac aaacaggatg ctgtcaaaga attagtactc atggagcatg agggtcgtga   2760

tgttgtcatt gctttgaaga ctaaacaggc aatccggaat gtgattgcta aagctctaaa   2820

aaatctcacc ttcctttgtt caagaggcat tattgataag catgaagtca ttgagataaa   2880

taaggtactt cttaaaaaat taaaagcact aaataacttt ccaaaggcaa tcccaccccc   2940

aactcctgac atataccttc acaacatcat ttggctggaa ggtaaagatg ttctcattga   3000

cttcttcaag gaaagagcca aacttgcctg ttttgactct ggagatacca tttgtaaagg   3060

aggtgaaatg ccacaaggaa tctacttaat tatttcagga atggcaattt tgcatagttt   3120

atctcctacc tttggaatag agagtaatca aaggtgtgat agagggtcca gtgacatgtt   3180

tacagagttc tgtactactg gggacataat tggagagcta agctgtctgc ttaagcgtga   3240

aattgaatat accgtcatct gtgaaactag tttacaggcc tgctttatct ccctggagga   3300

tttatatgaa ggctttgatg ccttctggcc atctctggaa tataaaatat ggctaaagct   3360

tgctctcagt actgcctatc agtattttga atcaagtctt attgatgagg acttaaggtt   3420

tcagaactgt gtgatgttca atcaagcata tgtggaaact ttatcaagct atagtgacat   3480

gattattgat aatatgacca tgaaatttgt tatcattgtg tatggcagtg taattgatac   3540

taagacagag gaaccatatt ttgcaccttg cattatacct acaacctgtg agcaggttca   3600

gggaacttct gatttaagca agctgctgat aatccaagca tctgagctta cccaaagaaa   3660

tagtaacacc aatgtcatgg cctcagtcaa cacggtcttt gaacaaccag gaaagaatat   3720

aaatggaaga caaaagatga gttgaaaact ggataccatt ttagaaaagg gtattaatga   3780

tacaaatatg atgtgtggag tcaggttaaa gaccaaacta ctttcctcgc tcaaatacta   3840

aaggattatc tgcaaggagt ttacttagaa gccactgaaa caggttactg ctgcatttag   3900

tttataagca atggatggac ttctgtaaaa cttcttaatt ttaagtagtt gcattatact   3960

tgggatgtta aaaaagtctt caggataata taaaatacac tgaaacatat gtcctaccaa   4020

atgaaaccct gtttccagct aagagcaaat tttaacatag tgcattataa aaagtgttgt   4080

ataactgata tgttactctc taaagcatag aacctgtaat tttcatttgt gaaattgtta   4140

taattagtgc ctccctaata ttttcccgag tatagctatt ctccccttcc cagtttggta   4200

aatattgaaa aacagaatta tattccacaa tcttagtaac tttcagtaag taagtaactt   4260

ttgctttcag tgaaatttag gagaaattaa tattctcata ttgcatagta ctgtttgatg   4320

tcacctttca ttttattttt aaaaatcaaa taaagttgag ttttatggtt gtctaaaaaa   4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa caaaaaaaaa aaaa                    4424


<210>  668
<211>  1124
<212>  PRT
<213>  Homosapiens

<400>  668

Met Ser Ser Tyr Phe Trp Ala Gln Asn Glu Ser Asn Arg Pro Asp Leu 
1               5                   10                  15      


Leu Cys Gly Gln Pro Ala Asp Tyr Leu Val Glu Glu Lys His Phe Thr 
            20                  25                  30          


Thr Leu Val Cys Phe Ile Val Val Leu Gly Gly Leu Leu Lys Met Cys 
        35                  40                  45              


Leu Lys Asn Cys Glu Val Ile Val Leu Thr Ile Leu Ser Leu Ser Gly 
    50                  55                  60                  


Phe Val Ile Gly His Met Ala Tyr Asn Ser Val Glu Val His Gln Ile 
65                  70                  75                  80  


Val Tyr Pro Leu Leu Arg Thr Ser Ser Phe Ser Leu Tyr Ser Tyr Phe 
                85                  90                  95      


Ser Pro Leu Ile Ile Phe Met Val Ala Leu Asp Val Glu Phe Tyr Thr 
            100                 105                 110         


Leu Lys Lys Met Phe Trp Gln Val Leu Leu Thr Gly Leu Ile Ser Phe 
        115                 120                 125             


Ser Thr Ala Ser Ile Ile Ile Gly Tyr Val Val Ile Lys Phe Asn Lys 
    130                 135                 140                 


Asp Ser Trp Asp Leu Gln Ser Cys Leu Leu Phe Ser Ile Thr Leu Gly 
145                 150                 155                 160 


Ile Ile Asp Pro Leu Arg Ser Val Asn Ser Leu Lys Thr Ile Gly Ile 
                165                 170                 175     


Ser Lys Ile Tyr Ile Asp Leu Ile Arg Gly Glu Ser Leu Ile Ile Cys 
            180                 185                 190         


Ser Ile Ala Ser Ile Phe Phe Gly Asn Phe Arg Gly Asn Arg Ile His 
        195                 200                 205             


Phe Ser Ile Phe Arg Asp Leu His Val Gly Ile Glu Leu Ser Tyr Asp 
    210                 215                 220                 


Ile Leu Gly Ser Ile Ile Phe Gly Tyr Trp Cys Ala Lys Ile Ile Gln 
225                 230                 235                 240 


Cys Ile Leu Ala Asp Val Phe Ser Asn Met Leu Thr Asn Ile Ile Leu 
                245                 250                 255     


Cys Phe Ser Met Val Tyr Met Thr Phe Tyr Ile Val Glu Phe Leu Gly 
            260                 265                 270         


Met Ser Gly Thr Leu Ala Leu Ala Ala Val Gly Leu Asn Leu Asp Ser 
        275                 280                 285             


Leu Thr Phe Lys Pro Lys Ile Glu Leu Val Ile Thr Lys Phe Leu Arg 
    290                 295                 300                 


Ile Phe Ser Ser Val Tyr Glu His Leu Ile Tyr Ala Phe Phe Gly Ile 
305                 310                 315                 320 


Val Ile Gly Cys Gly Glu Leu Ser His Tyr Glu Phe His Thr Ile Pro 
                325                 330                 335     


Phe Ile Phe Ile Leu Phe Thr Thr Val Asn Leu Val Arg Leu Leu Thr 
            340                 345                 350         


Ile Leu Leu Val Ser Pro Ile Leu Met His Ser Asn Tyr Glu Tyr Asn 
        355                 360                 365             


Trp Arg Trp Gly Val Val Ile Thr Trp Ser Gly Ile Lys Gly Val Phe 
    370                 375                 380                 


Asn Leu Leu Trp Ala Pro Asp Val Tyr Asn Leu Ala Glu Arg Lys Val 
385                 390                 395                 400 


Glu Val Pro Gln Met Phe Ile Leu Tyr Val Gln Val Ile Ser Leu Leu 
                405                 410                 415     


Thr Met Gly Ile Asn Ser Tyr Val Met Thr Gln Ser Ala Arg Lys Leu 
            420                 425                 430         


Asp Leu Cys Val Leu Ser Leu Pro Arg Gln Met Ile Leu Gln Asn Ala 
        435                 440                 445             


Thr Gln His Ile Gln Glu Ile Val Gln Asn Thr Ile Thr Leu Phe Lys 
    450                 455                 460                 


Thr Glu Lys Ile Leu Thr Asn Val Asn Trp Thr Leu Val Glu Asp Lys 
465                 470                 475                 480 


Thr Arg Ile Glu Tyr Ile Pro Phe Ser His Val Ser His Asn Asp Met 
                485                 490                 495     


Lys Thr Glu Ser Thr Thr Asp Glu Ala Leu Met Glu Glu Ala Arg Leu 
            500                 505                 510         


His Val Ala Ala Ile Gln Met Ser Ser Phe Glu Lys Gln Arg Asn Asn 
        515                 520                 525             


Gly Ile Leu Glu Ile Glu Ala Ala Arg Ile Leu Ile Gly Ala Ala Lys 
    530                 535                 540                 


Cys Tyr Tyr Ser Ile Gln Gly Lys Phe Met Ser Ile Tyr Asp Val Ser 
545                 550                 555                 560 


Thr Tyr Met Arg Thr Arg Ser Trp Leu Ile Lys Phe Lys Asn Val Leu 
                565                 570                 575     


Thr Phe Leu Glu Tyr Cys Ile Glu Lys Ile His Phe Ile Pro Pro Glu 
            580                 585                 590         


Ser Asn Thr Phe Leu Thr Phe Ile Phe His Ile Val Phe Ser Glu Glu 
        595                 600                 605             


Phe Glu Tyr Thr Gly Gln Ile Ile Asn Leu Ile Tyr Ile Tyr Pro Met 
    610                 615                 620                 


Ile Ile His Leu Trp Pro Met Ala Arg Gly Leu Asn Val Ser Ala Leu 
625                 630                 635                 640 


Ile Ser Ile Asn Tyr Tyr Phe Met Phe Leu Tyr Val Leu Glu Ser Thr 
                645                 650                 655     


Leu Lys Ile Ile Ile Leu Lys Arg Lys Tyr Phe Gln Gln Cys Trp Asn 
            660                 665                 670         


Thr Leu Glu Phe Phe Ile Leu Val Ile Gly Ile Ile Asp Ile Phe Cys 
        675                 680                 685             


Val Tyr Phe Val Lys Leu Arg Pro Asp Asn Leu Ala Leu Ile Gln Leu 
    690                 695                 700                 


Thr Val Ile Met Gly Tyr Leu Arg Ile Ile Arg Phe Leu Pro Leu Phe 
705                 710                 715                 720 


Lys Ile Ile Val Pro Ile Leu Ile Arg Ile Ala Asp Val Gln Ile Lys 
                725                 730                 735     


Lys Arg Leu Ser Leu Met Tyr Ser Ile Thr Lys Gly Tyr Ile Lys Ser 
            740                 745                 750         


Gln Glu Asp Ala Lys Leu Leu Ile Lys Gln Ile Ala Val Cys Glu Ser 
        755                 760                 765             


Ile Tyr Gln Lys Leu Cys Glu Ile Leu Glu Thr Asn Lys Gln Asp Ala 
    770                 775                 780                 


Val Lys Glu Leu Val Leu Met Glu His Glu Gly Arg Asp Val Val Ile 
785                 790                 795                 800 


Ala Leu Lys Thr Lys Gln Ala Ile Arg Asn Val Ile Ala Lys Ala Leu 
                805                 810                 815     


Lys Asn Leu Thr Phe Leu Cys Ser Arg Gly Ile Ile Asp Lys His Glu 
            820                 825                 830         


Val Ile Glu Ile Asn Lys Val Leu Leu Lys Lys Leu Lys Ala Leu Asn 
        835                 840                 845             


Asn Phe Pro Lys Ala Ile Pro Pro Pro Thr Pro Asp Ile Tyr Leu His 
    850                 855                 860                 


Asn Ile Ile Trp Leu Glu Gly Lys Asp Val Leu Ile Asp Phe Phe Lys 
865                 870                 875                 880 


Glu Arg Ala Lys Leu Ala Cys Phe Asp Ser Gly Asp Thr Ile Cys Lys 
                885                 890                 895     


Gly Gly Glu Met Pro Gln Gly Ile Tyr Leu Ile Ile Ser Gly Met Ala 
            900                 905                 910         


Ile Leu His Ser Leu Ser Pro Thr Phe Gly Ile Glu Ser Asn Gln Arg 
        915                 920                 925             


Cys Asp Arg Gly Ser Ser Asp Met Phe Thr Glu Phe Cys Thr Thr Gly 
    930                 935                 940                 


Asp Ile Ile Gly Glu Leu Ser Cys Leu Leu Lys Arg Glu Ile Glu Tyr 
945                 950                 955                 960 


Thr Val Ile Cys Glu Thr Ser Leu Gln Ala Cys Phe Ile Ser Leu Glu 
                965                 970                 975     


Asp Leu Tyr Glu Gly Phe Asp Ala Phe Trp Pro Ser Leu Glu Tyr Lys 
            980                 985                 990         


Ile Trp Leu Lys Leu Ala Leu Ser  Thr Ala Tyr Gln Tyr  Phe Glu Ser 
        995                 1000                 1005             


Ser Leu  Ile Asp Glu Asp Leu  Arg Phe Gln Asn Cys  Val Met Phe 
    1010                 1015                 1020             


Asn Gln  Ala Tyr Val Glu Thr  Leu Ser Ser Tyr Ser  Asp Met Ile 
    1025                 1030                 1035             


Ile Asp  Asn Met Thr Met Lys  Phe Val Ile Ile Val  Tyr Gly Ser 
    1040                 1045                 1050             


Val Ile  Asp Thr Lys Thr Glu  Glu Pro Tyr Phe Ala  Pro Cys Ile 
    1055                 1060                 1065             


Ile Pro  Thr Thr Cys Glu Gln  Val Gln Gly Thr Ser  Asp Leu Ser 
    1070                 1075                 1080             


Lys Leu  Leu Ile Ile Gln Ala  Ser Glu Leu Thr Gln  Arg Asn Ser 
    1085                 1090                 1095             


Asn Thr  Asn Val Met Ala Ser  Val Asn Thr Val Phe  Glu Gln Pro 
    1100                 1105                 1110             


Gly Lys  Asn Ile Asn Gly Arg  Gln Lys Met Ser 
    1115                 1120                 


<210>  669
<211>  2670
<212>  DNA
<213>  Homosapiens

<400>  669
gttgcgccgt tgctatggta accgaggagg ccggggcccg ggtgtggtat ttttggagtt     60

aatggagtca gaaggacctc cagagtcaga gagttcagaa tttttctcac agcaagaaga    120

ggaaaatgaa gaagaagaag cccaagaacc agaggaaaca ggccctaaga accccctttt    180

acaacctgct ctcacagggg atgtagaggg tttgcagaag atatttgagg atcctgagaa    240

tcctcatcat gaacaggcca tgcagcttct cttagaagaa gacatcgttg ggagaaattt    300

gttgtatgca gcttgcatgg ctgggcaaag tgacgtgatt agagctttgg caaaatatgg    360

tgtgaatctg aatgaaaaaa ccaccagagg gtacacactc ttacattgtg ctgcagcctg    420

gggtcgtttg gaaactttga aagcactggt agaactggat gttgatatag aagctttgaa    480

cttccgggaa gaaagggctc gagatgttgc tgctagatat tctcagactg agtgtgttga    540

attcctggac tgggcagatg caaggctgac tctgaaaaaa tatattgcaa aagtctcttt    600

agctgttact gacacagaaa agggatcagg gaaactcctt aaggaagaca agaataccat    660

cctcagtgca tgccgtgcaa aaaatgagtg gttggaaacc catacagaag cttccattaa    720

tgagcttttt gagcagagac aacaactgga agatattgtg actcctatct tcacaaaaat    780

gactacacca tgtcaagtga aaagtgccaa atctgtaaca agccatgacc agaagagaag    840

tcaagatgat acctccaact gaacatacgt tctgtaaaag gccacatttt cttttagtat    900

ctgaaaggca aacctattca tgccatttga aatcgagaaa acagatgtgg gtttctttaa    960

gtatttaagt acaacattac atcgcccttg ttttgtttga cctgttcagc atgcttatgt   1020

ccggactctg gcctcgcctc tgctcctcca agcacagccc catgtgagtt tcacgtgctc   1080

cttcaggaaa gcacttgggt ataaatcatt cgtgaagacc atgtggaggc tttaagaact   1140

actcagagaa tctaataatt ttctgtgtaa ttgaggcatt ccatataaaa ggacatattt   1200

ggctatttcc agagaaaaaa tttgttctcc ctgcctaaaa aggaaatctt atggaatgac   1260

acttggagca aggaaatatt aagaccagct tggattagga gcctctgggt acaactatca   1320

ctttttatgt ccaaaattaa atttcacctg tgaggtgggg tatacctctg agtaaaaccc   1380

ctctttatct ttgacctcct tctatctgta aattaataaa cacaaatctg tatagtttta   1440

tacttagaag agttctccta ttctgtaagg ctggcaatac agatattgta actggactga   1500

agaccatttc ccctcccatt ctgttttata tttcctaggt tttaagtacg atagttggtt   1560

tcatattggt ggtttggaaa gccttttttc taatttattt aatcaggcgc ctcaaccttc   1620

tcttacgttg tgactttatg gaaaagtttt atagaaaaga agatggtttt taaaaagcac   1680

ttattgttcg ttcttatggc tttctcttct ttgtcctgtt ctgaaagcta gttttccctt   1740

atggggagaa ggaaaaggaa tgggtaattc agtaatactt tgtcagttga catttattta   1800

accatggttt tgagataacc ctgttttaaa tgtctcccaa agtttttagt tttttatcct   1860

tttaatgtat gagcaattca gtttcaattt tttaaagcaa aagaacactg caataacttt   1920

cagccacctt tttggccgac ccagtgggtg tttatggagc agtacaaaga agacctgtgt   1980

ttgctccttt ttttttttac cctccttctc ccttctccct tttcccttcc cttccccttc   2040

tccttcctct cccttcctct cccttcccct cccttcccct cccttcccct cccttcctct   2100

cccttcctct cccctcccct cccttcctct cccctcccct cccttcctct cccctcccct   2160

ccccctcctc ttctctctcc tcctcctctt ccctctccaa ctccttcttc tccctctctt   2220

atctctctct ctctctccac ccccgcaacc ttcttgacag ggtctgcctc tcctgcccag   2280

gctggaatgc agtggagtta tcatgatcat agctcactgt aacctgtaac tcctgcactc   2340

aagtgatcct cccaccatgc ttgggtaatt gaaaaaataa acatttgcag gctgggtgct   2400

ggctcacacc tgtaatccaa gaactttggg aggccaaggc aggcggatca cctgaggtca   2460

gcggtttgag acaagcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa   2520

tttagctgta tgtggtggca cgtgcctgta atcccagtga cttgggaggc tgaggcagga   2580

gaatcacctg ggcccgggag gtggaggttg cagtgagccg agatcgcacc actgcattcc   2640

agcctgggtg acagagtgag actccatctc                                    2670


<210>  670
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  670

Met Glu Ser Glu Gly Pro Pro Glu Ser Glu Ser Ser Glu Phe Phe Ser 
1               5                   10                  15      


Gln Gln Glu Glu Glu Asn Glu Glu Glu Glu Ala Gln Glu Pro Glu Glu 
            20                  25                  30          


Thr Gly Pro Lys Asn Pro Leu Leu Gln Pro Ala Leu Thr Gly Asp Val 
        35                  40                  45              


Glu Gly Leu Gln Lys Ile Phe Glu Asp Pro Glu Asn Pro His His Glu 
    50                  55                  60                  


Gln Ala Met Gln Leu Leu Leu Glu Glu Asp Ile Val Gly Arg Asn Leu 
65                  70                  75                  80  


Leu Tyr Ala Ala Cys Met Ala Gly Gln Ser Asp Val Ile Arg Ala Leu 
                85                  90                  95      


Ala Lys Tyr Gly Val Asn Leu Asn Glu Lys Thr Thr Arg Gly Tyr Thr 
            100                 105                 110         


Leu Leu His Cys Ala Ala Ala Trp Gly Arg Leu Glu Thr Leu Lys Ala 
        115                 120                 125             


Leu Val Glu Leu Asp Val Asp Ile Glu Ala Leu Asn Phe Arg Glu Glu 
    130                 135                 140                 


Arg Ala Arg Asp Val Ala Ala Arg Tyr Ser Gln Thr Glu Cys Val Glu 
145                 150                 155                 160 


Phe Leu Asp Trp Ala Asp Ala Arg Leu Thr Leu Lys Lys Tyr Ile Ala 
                165                 170                 175     


Lys Val Ser Leu Ala Val Thr Asp Thr Glu Lys Gly Ser Gly Lys Leu 
            180                 185                 190         


Leu Lys Glu Asp Lys Asn Thr Ile Leu Ser Ala Cys Arg Ala Lys Asn 
        195                 200                 205             


Glu Trp Leu Glu Thr His Thr Glu Ala Ser Ile Asn Glu Leu Phe Glu 
    210                 215                 220                 


Gln Arg Gln Gln Leu Glu Asp Ile Val Thr Pro Ile Phe Thr Lys Met 
225                 230                 235                 240 


Thr Thr Pro Cys Gln Val Lys Ser Ala Lys Ser Val Thr Ser His Asp 
                245                 250                 255     


Gln Lys Arg Ser Gln Asp Asp Thr Ser Asn 
            260                 265     


<210>  671
<211>  3505
<212>  DNA
<213>  Homosapiens

<400>  671
atgggccggt gaagggaaag gaaatagctc tacgagcggc atcctgcctg cgttagcggc     60

ggtggaggag gaggcagaga ggagtggagg gcggagtaga cggaggaggc tgctgcagag    120

aagaaagtgt cagagccggt tcggctttag agtgtggtga agggtacttt tcatggtgca    180

tggaaggaaa gccaatgcgc aggtgtacca acattcgacc aggagagact ggaatggatg    240

taacaagccg ctgcaccctt ggagacccca acaaactgcc agaaggggtt ccccaacctg    300

cccgcatgcc ctatatctca gacaagcacc ctcgacaaac cttggaagtg attaaccttc    360

tgagaaagca ccgggagcta tgtgatgtgg tgctagttgt gggcgccaag aagatatatg    420

cccatcgagt cattttgtca gcctgtagtc cctacttccg agctatgttt acaggagaat    480

tggcagagag ccgtcagaca gaagtagtga tccgagacat tgacgagagg gctatggaat    540

tactgattga ctttgcgtat acctcccaga taacagtaga agagggcaat gttcagactc    600

ttctgccagc tgcttgcctc ctccagctgg cagaaataca ggaagcctgc tgtgaattct    660

taaagagaca attagatcct tctaactgcc tgggcattcg ggcttttgct gacacacatt    720

catgtcgtga gttgctaagg atagcagaca agttcaccca acataacttt caagaggtaa    780

tggagagtga agagttcatg ttgcttccag ccaatcaact cattgatata atatccagtg    840

atgagctaaa cgttcgcagt gaagaacaag tgttcaatgc agtgatggcc tgggtcaaat    900

acagtattca ggaaagacgt cctcaattac cccaggtgct gcagcatgtt cgtttgcctt    960

tgcttagtcc caagttcctg gtcggcacag taggctctga tcccctcatc aaaagtgatg   1020

aagaatgcag agacttggta gatgaggcta aaaactacct cctattgccg caagaacgac   1080

cactaatgca aggaccaagg acgagaccac ggaaacctat ccgatgtggg gaagtactct   1140

ttgcagttgg tggttggtgc agtggagatg ccatttccag tgttgaacga tatgatccac   1200

agaccaatga atggagaatg gtggcttcaa tgagcaaaag gagatgcgga gttggggtca   1260

gtgttcttga tgatctgtta tatgcagtag gaggccatga tggatcctct tatctcaata   1320

gtgttgaaag gtatgacccc aaaacaaacc agtggagcag tgatgtggcc cctacaagca   1380

cctgcaggac aagtgttggt gtagcagtac ttggaggctt tctttatgct gtgggtggcc   1440

aggatggtgt gtcttgcctc aacattgttg agaggtatga tccgaaggag aacaagtgga   1500

ctcgggtagc ttctatgagt accagaagac taggtgtggc tgtggctgtg ttaggagggt   1560

tcttatatgc tgtaggtggc tctgacggga catctcctct caacacagtg gaacgttaca   1620

atcctcagga aaacagatgg cacactatag cccctatggg gacccggagg aaacacctag   1680

gctgtgcagt atatcaggac atgatctatg ctgtaggagg tagagatgac actacagagc   1740

tgagcagtgc tgagagatac aaccccagaa ccaaccagtg gtctccagtg gtggccatga   1800

catcacgccg tagtggagtt ggcctggcag tggtcaatgg acagctcatg gcagtaggag   1860

gttttgatgg cacaacatac ttgaagacca tagaagtttt tgatcctgat gccaatacat   1920

ggaggttata tggcgggatg aattaccgtc ggctaggggg tggcgtagga gttattaaaa   1980

tgacacattg tgaatcccat atttggtgaa cacagagaag acagtcttgt atatattcct   2040

ctgtattctg gggagctttg accttggagc tttgtacagc ttgagaaaac attagaacaa   2100

attttattat ttgccggtgc ctcaacaaat ggaaatacaa tccaatgaaa gtacttcacc   2160

tgcaagatgc acaataattt tcaactctgt gcagaagaat atttattttt ggttttaatt   2220

tatcatggtt ttttgttgtt ttcgttttga acttatcctt cctcccacaa aaaaagaaaa   2280

gaagaaaaaa ttccaagcag caaaacttac tttgtttgta aggtattcat ttaggtttga   2340

aaatactatt taataagggc agaagggcta tatatgattt ggctattatt tctagacact   2400

ccatccacat gattccacta acaaggatta ccaggaataa aggtaggtat gcaaaatgta   2460

ttagctaccc attattctcg cactaaccac cagaagactt gaaaatctta aaaaaaaaaa   2520

acaaaaaaac aagaaaaggc aacatctcat tttaaatagt acaattcaga agggatacta   2580

aatcaataaa aaccaggact cagacactac agttttcatc agtgtaattt tatgtcttgt   2640

ttctttctat atgaacttgt ttatttagtc tttttttcat aatattctca tagagtttct   2700

gctagatcta gagctctgct cagtgcctct tataaaaaca atatataagt ctcatatgct   2760

gtcttgagaa tccaagagaa tcacatgcag ctctgcaaca gtttttgctc aaaaatgtta   2820

ctgactaaag caactgtcct tcctgtttcc ttattgctac caaggaccag cagggagaaa   2880

tgtcttctcc cagcagtgaa ttctgttatg caatttattc ttgatgctca ggcctggtta   2940

agctgaggct tacctttaat aacagcctcc aagggaatga attattcagt taatgtaata   3000

gcacacatta aagagtgtaa aatcaattga ggcattttat taatatcttg gttcttttat   3060

acaaacaatg tatcattatc ttcattctat aaggtcattg ttactacttc tctcaaattg   3120

cactttctgg taaaaagtta aaaattttta aggaaaaaat aatttcaatg gttaaagttt   3180

tttttcctca ttgtattcat agacaaattt ttttcaatat attttgcaag aaaaatcttt   3240

gaataagact aactgcattt aaaaggaata acctccttct ccctttcccc aactacaaaa   3300

atgtttggca actttgtgtt tacatttaaa gatcatttgc acctttttca aggaaaaaaa   3360

gtattgagta aacaattgtt tacatatatc atttatgctt ttttctagca tgtataactt   3420

ttttaaataa aggtagtatt taccattaaa aaaattttag ctaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaaaa                                         3505


<210>  672
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  672

Met Glu Gly Lys Pro Met Arg Arg Cys Thr Asn Ile Arg Pro Gly Glu 
1               5                   10                  15      


Thr Gly Met Asp Val Thr Ser Arg Cys Thr Leu Gly Asp Pro Asn Lys 
            20                  25                  30          


Leu Pro Glu Gly Val Pro Gln Pro Ala Arg Met Pro Tyr Ile Ser Asp 
        35                  40                  45              


Lys His Pro Arg Gln Thr Leu Glu Val Ile Asn Leu Leu Arg Lys His 
    50                  55                  60                  


Arg Glu Leu Cys Asp Val Val Leu Val Val Gly Ala Lys Lys Ile Tyr 
65                  70                  75                  80  


Ala His Arg Val Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Ala Met 
                85                  90                  95      


Phe Thr Gly Glu Leu Ala Glu Ser Arg Gln Thr Glu Val Val Ile Arg 
            100                 105                 110         


Asp Ile Asp Glu Arg Ala Met Glu Leu Leu Ile Asp Phe Ala Tyr Thr 
        115                 120                 125             


Ser Gln Ile Thr Val Glu Glu Gly Asn Val Gln Thr Leu Leu Pro Ala 
    130                 135                 140                 


Ala Cys Leu Leu Gln Leu Ala Glu Ile Gln Glu Ala Cys Cys Glu Phe 
145                 150                 155                 160 


Leu Lys Arg Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe 
                165                 170                 175     


Ala Asp Thr His Ser Cys Arg Glu Leu Leu Arg Ile Ala Asp Lys Phe 
            180                 185                 190         


Thr Gln His Asn Phe Gln Glu Val Met Glu Ser Glu Glu Phe Met Leu 
        195                 200                 205             


Leu Pro Ala Asn Gln Leu Ile Asp Ile Ile Ser Ser Asp Glu Leu Asn 
    210                 215                 220                 


Val Arg Ser Glu Glu Gln Val Phe Asn Ala Val Met Ala Trp Val Lys 
225                 230                 235                 240 


Tyr Ser Ile Gln Glu Arg Arg Pro Gln Leu Pro Gln Val Leu Gln His 
                245                 250                 255     


Val Arg Leu Pro Leu Leu Ser Pro Lys Phe Leu Val Gly Thr Val Gly 
            260                 265                 270         


Ser Asp Pro Leu Ile Lys Ser Asp Glu Glu Cys Arg Asp Leu Val Asp 
        275                 280                 285             


Glu Ala Lys Asn Tyr Leu Leu Leu Pro Gln Glu Arg Pro Leu Met Gln 
    290                 295                 300                 


Gly Pro Arg Thr Arg Pro Arg Lys Pro Ile Arg Cys Gly Glu Val Leu 
305                 310                 315                 320 


Phe Ala Val Gly Gly Trp Cys Ser Gly Asp Ala Ile Ser Ser Val Glu 
                325                 330                 335     


Arg Tyr Asp Pro Gln Thr Asn Glu Trp Arg Met Val Ala Ser Met Ser 
            340                 345                 350         


Lys Arg Arg Cys Gly Val Gly Val Ser Val Leu Asp Asp Leu Leu Tyr 
        355                 360                 365             


Ala Val Gly Gly His Asp Gly Ser Ser Tyr Leu Asn Ser Val Glu Arg 
    370                 375                 380                 


Tyr Asp Pro Lys Thr Asn Gln Trp Ser Ser Asp Val Ala Pro Thr Ser 
385                 390                 395                 400 


Thr Cys Arg Thr Ser Val Gly Val Ala Val Leu Gly Gly Phe Leu Tyr 
                405                 410                 415     


Ala Val Gly Gly Gln Asp Gly Val Ser Cys Leu Asn Ile Val Glu Arg 
            420                 425                 430         


Tyr Asp Pro Lys Glu Asn Lys Trp Thr Arg Val Ala Ser Met Ser Thr 
        435                 440                 445             


Arg Arg Leu Gly Val Ala Val Ala Val Leu Gly Gly Phe Leu Tyr Ala 
    450                 455                 460                 


Val Gly Gly Ser Asp Gly Thr Ser Pro Leu Asn Thr Val Glu Arg Tyr 
465                 470                 475                 480 


Asn Pro Gln Glu Asn Arg Trp His Thr Ile Ala Pro Met Gly Thr Arg 
                485                 490                 495     


Arg Lys His Leu Gly Cys Ala Val Tyr Gln Asp Met Ile Tyr Ala Val 
            500                 505                 510         


Gly Gly Arg Asp Asp Thr Thr Glu Leu Ser Ser Ala Glu Arg Tyr Asn 
        515                 520                 525             


Pro Arg Thr Asn Gln Trp Ser Pro Val Val Ala Met Thr Ser Arg Arg 
    530                 535                 540                 


Ser Gly Val Gly Leu Ala Val Val Asn Gly Gln Leu Met Ala Val Gly 
545                 550                 555                 560 


Gly Phe Asp Gly Thr Thr Tyr Leu Lys Thr Ile Glu Val Phe Asp Pro 
                565                 570                 575     


Asp Ala Asn Thr Trp Arg Leu Tyr Gly Gly Met Asn Tyr Arg Arg Leu 
            580                 585                 590         


Gly Gly Gly Val Gly Val Ile Lys Met Thr His Cys Glu Ser His Ile 
        595                 600                 605             


Trp 
    


<210>  673
<211>  1910
<212>  DNA
<213>  Homosapiens

<400>  673
gtctctgaca ggctcagctg gagagggacg ggttgggacg cactgtcctt ttgcccttcc     60

ccctccgcga gcagaagctg actccgcagg agcgagggtc gcagagctgg gtgagcggaa    120

atgtccctcc cagagtgaag tcgcagggcc cgccccgcgt ctgagggagc ggaggtcttc    180

ctgggggatt tcagtctcca catagttttg gagccggact tttgaagaat gattcgtgaa    240

tccggaatgg gtgacagcgt catcacggca ttttattgac agaccatgga ttcttacagt    300

gcaccagagt caactcctag tgcatcctca agacctgaag attactttat aggtgccact    360

cctctgcaga aacgattaga atcggtcagg aagcagagtt catttatcct gactccacct    420

cgaaggaaaa ttccccagtg ttcgcagttg caggaagatg ttgaccctca aaaggttgca    480

ttccttctgc ataaacagtg gactttatat agtttaactc ccttatataa attctcctat    540

agtaatctca aagagtattc tagacttctc aatgctttta ttgttgctga aaagcaaaaa    600

ggacttgctg tggaagtggg agaagacttc aacatcaaag tgattttttc tactctccta    660

ggaatgaaag gaacacaaag ggacccggaa gcatttcttg tccagattgt gtcaaaatct    720

caattgccat ctgagaatag agaaggtaaa gtgctgtgga ctggctggtt ctgctgtgta    780

tttggagaca gtcttctgga gactgtttca gaagatttca cctgtctgcc cttattcctt    840

gcaaatggag cagagtctaa cacagcaata attggaactt ggtttcagaa aacctttgac    900

tgttatttca gtcctttagc aatcaatgca tttaatcttt cctggatggc tgccatgtgg    960

actgcatgca aaatggacca ttatgtggct actactgaat ttctttggtc tgtaccctgt   1020

agccctcaaa gtctggacat ttctttcgca atacatccag aggatgcaaa agctctatgg   1080

gacagtgtcc acaaaacacc tggggaggtt acccaggaag aagttgacct attcatggat   1140

tgcctttatt cacatttcca tagacatttc aaaattcatt tatcagccac aagattagtt   1200

cgtgtttcaa catctgtagc ttcagcacat actgatggaa aaataaagat tctgtgtcat   1260

aaatacctta ttggagtgtt agcatatttg acagaactgg caatttttca aattgagtga   1320

agccttatgt ggactataag ttatagatta tatactctta ttgataactt gcctaattgc   1380

tatgctgaaa gagactgcag gagaaatagg catctatctc tgcatctgtt ttccccacca   1440

tgcctttgga gttgccaaga tggaagccaa gaaggatcta gaagaacaaa gaatatggta   1500

gtagatgagc cacagccagg tgcccatgta ctaatcatga taacctgaca tgccattctc   1560

aaaatgctga gttgttaatt tcttgtcatc tttaaatata tatatatagg ctgggcttgg   1620

tggctcacac ctgtaattcc agcactttgg gaggctgagg tgggtggatc atttgaggcc   1680

aggaattcaa gaccagcctg gccaacatgg tgaaacccct tctctactga aaatacaata   1740

attagctggg cgtggtggca catgcctgtg atcccagcta ctggggaggc tgaggcagga   1800

gaatcgtttt aacccagaag acaggctgca gtgagccaag actgcaccac tgcactccag   1860

cctgggcaac aaagtgagac tctgcctcaa aaaataaaaa aaaaaaaaaa              1910


<210>  674
<211>  344
<212>  PRT
<213>  Homosapiens

<400>  674

Met Asp Ser Tyr Ser Ala Pro Glu Ser Thr Pro Ser Ala Ser Ser Arg 
1               5                   10                  15      


Pro Glu Asp Tyr Phe Ile Gly Ala Thr Pro Leu Gln Lys Arg Leu Glu 
            20                  25                  30          


Ser Val Arg Lys Gln Ser Ser Phe Ile Leu Thr Pro Pro Arg Arg Lys 
        35                  40                  45              


Ile Pro Gln Cys Ser Gln Leu Gln Glu Asp Val Asp Pro Gln Lys Val 
    50                  55                  60                  


Ala Phe Leu Leu His Lys Gln Trp Thr Leu Tyr Ser Leu Thr Pro Leu 
65                  70                  75                  80  


Tyr Lys Phe Ser Tyr Ser Asn Leu Lys Glu Tyr Ser Arg Leu Leu Asn 
                85                  90                  95      


Ala Phe Ile Val Ala Glu Lys Gln Lys Gly Leu Ala Val Glu Val Gly 
            100                 105                 110         


Glu Asp Phe Asn Ile Lys Val Ile Phe Ser Thr Leu Leu Gly Met Lys 
        115                 120                 125             


Gly Thr Gln Arg Asp Pro Glu Ala Phe Leu Val Gln Ile Val Ser Lys 
    130                 135                 140                 


Ser Gln Leu Pro Ser Glu Asn Arg Glu Gly Lys Val Leu Trp Thr Gly 
145                 150                 155                 160 


Trp Phe Cys Cys Val Phe Gly Asp Ser Leu Leu Glu Thr Val Ser Glu 
                165                 170                 175     


Asp Phe Thr Cys Leu Pro Leu Phe Leu Ala Asn Gly Ala Glu Ser Asn 
            180                 185                 190         


Thr Ala Ile Ile Gly Thr Trp Phe Gln Lys Thr Phe Asp Cys Tyr Phe 
        195                 200                 205             


Ser Pro Leu Ala Ile Asn Ala Phe Asn Leu Ser Trp Met Ala Ala Met 
    210                 215                 220                 


Trp Thr Ala Cys Lys Met Asp His Tyr Val Ala Thr Thr Glu Phe Leu 
225                 230                 235                 240 


Trp Ser Val Pro Cys Ser Pro Gln Ser Leu Asp Ile Ser Phe Ala Ile 
                245                 250                 255     


His Pro Glu Asp Ala Lys Ala Leu Trp Asp Ser Val His Lys Thr Pro 
            260                 265                 270         


Gly Glu Val Thr Gln Glu Glu Val Asp Leu Phe Met Asp Cys Leu Tyr 
        275                 280                 285             


Ser His Phe His Arg His Phe Lys Ile His Leu Ser Ala Thr Arg Leu 
    290                 295                 300                 


Val Arg Val Ser Thr Ser Val Ala Ser Ala His Thr Asp Gly Lys Ile 
305                 310                 315                 320 


Lys Ile Leu Cys His Lys Tyr Leu Ile Gly Val Leu Ala Tyr Leu Thr 
                325                 330                 335     


Glu Leu Ala Ile Phe Gln Ile Glu 
            340                 


<210>  675
<211>  3187
<212>  DNA
<213>  Homosapiens

<400>  675
ggttctggcc gcgggagcct ctcgagaagc gtggaaagag gagaagggcg tataccttgt     60

gaccgcctct ggttgtcttg ggctcgcgcc tggcgccgct acgtggagtc gctctctcgt    120

cgtcactttt ggctgccgac ttgttgagta gaagtgcaga ctgatgcttt aagactcagg    180

gagaggtctt tcccttatct ccaccccagc aagcacccca gagaccttgg agatttgtct    240

tgtttctaga cacgtgtact ccaatgttgt gcggaggagg ccttaaatat tcgagaagag    300

agtgggaact cctggaattt taagggattt ctgtgtattt ccaaaactga cttttaacta    360

ccggcagcgt gggatttcgt gattgttttt cgccatcgtg tggctccaac atgtacttcc    420

cttcttggtt aagtcagctg tacaggggtt tatccagacc catcagaagg accacccaac    480

cgatctgggg ttctctctac agaagtctgt tgcagagttc acagaggaga attccagaat    540

tcagtagctt tgttgtccgg accaacacat gtggagagtt gcgttcgtct cacttaggcc    600

aagaagtcac cttgtgtgga tggattcagt accgaaggca aaacacattc ttggtcctaa    660

gagatttcga tgggcttgtt caagttatca ttccccagga tgagtcggca gcctctgtga    720

agaagatttt atgtgaagcc cctgtggaat ctgtggtgca agtgtctggt acagtcattt    780

cccgtcctgc aggacaagag aatccaaaaa tgccaacagg tgagattgaa atcaaagtta    840

aaacagctga gcttctgaat gcctgcaaga agctgccctt tgaaattaag aacttcgtga    900

agaaaacaga ggctcttcgg ttgcagtatc gctacttaga cttgcgtagt ttccaaatgc    960

agtataacct gcgactgagg tcccagatgg tcatgaaaat gcgggaatat ctctgtaatc   1020

tgcatgggtt tgtggatata gaaaccccca cattgtttaa gaggacccca gggggtgcca   1080

aagagttttt agtaccatcc agggaacctg gaaagtttta ttctctccct cagagtcctc   1140

aacagtttaa gcaacttctg atggttggcg gtttagacag atattttcag gttgcccgat   1200

gttatcgaga tgaaggttca agaccagaca gacagcctga gtttactcag attgacatag   1260

agatgtcatt tgtagaccag actgggatcc agagtttaat tgagggtttg ctccagtatt   1320

cctggcccaa tgacaaagat cctgtggttg ttccttttcc tactatgact tttgctgagg   1380

tgctggccac ctatggaact gataaacctg acactcgctt tggaatgaag attatagata   1440

tcagtgatgt gtttagaaac acagagattg gatttcttca agatgcactt agtaagcccc   1500

atggaactgt gaaagccata tgtatccctg aaggagcaaa atacttaaaa aggaaagaca   1560

ttgaatccat tagaaacttt gcagctgacc attttaatca ggaaatctta cctgtattcc   1620

ttaacgccaa tagaaactgg aattctccag ttgctaattt cataatggag tcacaaagac   1680

tggaattaat cagactaatg gagacccaag aggaagatgt ggtcctacta actgctggag   1740

agcacaataa agcatgctct ttgttaggaa aattacgact ggaatgtgct gaccttctag   1800

aaacaagagg agtggtgctc cgtgacccca ctctgttctc tttcctttgg gtggtagatt   1860

tcccactctt cctgcccaag gaggaaaatc ccagagagct ggaatcggcc caccacccat   1920

ttactgctcc ccaccccagt gacatacatc tcctgtacac tgagcccaaa aaggcccgta   1980

gccaacacta tgacttggtt ttaaatggca atgaaatagg aggtggttca attcgaattc   2040

acaatgcaga gctgcagcgt tatatcctgg caaccttact aaaggaggat gtgaaaatgc   2100

tctcccatct gctccaggct ttagattatg gggcaccccc tcatggagga attgccttag   2160

ggttagacag actgatatgc cttgtcactg gatctccaag catcagagat gtcatagcct   2220

tcccaaagtc cttccgggga catgacctca tgagcaatac cccagattct gtccctcctg   2280

aggaactgaa gccctatcat atccgagtct ccaagccaac agactccaaa gcagaaagag   2340

ctcattgaat catgcatacc atgcagaaag ttgagctttt aggttttgtc ctctttgctt   2400

ccccaaggct aaagtcagat ctagagttct gccacaggtc taacaatcaa gtctttagat   2460

ggaaggaatc caggcaacat tcttcaccac aacgaagaaa cagataaaag atacccaatt   2520

ttgacttgat ttcatgcatc atttggattt tttttggtta ggactttttt tgaagttcct   2580

ttttacttag gtgtgaaaga tggttctttg ttgaaataat atagtggttt agtgttttca   2640

aatcatgttt ctcataccca gatagtagat tattcactta ggacagaggt aatcaaatta   2700

tgtgtgaaat gtaggaaaat gcttgcccct gtaaactagt gagttgatgg agcatttgct   2760

tcatcatcct catcaagaga atcatataaa ttaagcttta taatgacatt tcaaccatca   2820

acataatata gtgaggagta gcataatatt ttttaataat gcagaaaaca tcactgaaat   2880

gagagtcaca aatttttctt cagtgtttca gcctgagtaa gttacataaa cctcgcttag   2940

cctcccttcc tgctaatgtg taaaatacat acttgccctg gctacctcac cgggctgtta   3000

ttgctggaat cagaggagat aacatatatg gaagataaag tgaataaaag tactttgaaa   3060

aactataaag cattccacaa atatgagatg atggtattat ccatccataa ataggtagat   3120

atatctctat tttatagttt cagattaaac aaaactgata tcaatagtaa aagtcatttt   3180

acttatc                                                             3187


<210>  676
<211>  645
<212>  PRT
<213>  Homosapiens

<400>  676

Met Tyr Phe Pro Ser Trp Leu Ser Gln Leu Tyr Arg Gly Leu Ser Arg 
1               5                   10                  15      


Pro Ile Arg Arg Thr Thr Gln Pro Ile Trp Gly Ser Leu Tyr Arg Ser 
            20                  25                  30          


Leu Leu Gln Ser Ser Gln Arg Arg Ile Pro Glu Phe Ser Ser Phe Val 
        35                  40                  45              


Val Arg Thr Asn Thr Cys Gly Glu Leu Arg Ser Ser His Leu Gly Gln 
    50                  55                  60                  


Glu Val Thr Leu Cys Gly Trp Ile Gln Tyr Arg Arg Gln Asn Thr Phe 
65                  70                  75                  80  


Leu Val Leu Arg Asp Phe Asp Gly Leu Val Gln Val Ile Ile Pro Gln 
                85                  90                  95      


Asp Glu Ser Ala Ala Ser Val Lys Lys Ile Leu Cys Glu Ala Pro Val 
            100                 105                 110         


Glu Ser Val Val Gln Val Ser Gly Thr Val Ile Ser Arg Pro Ala Gly 
        115                 120                 125             


Gln Glu Asn Pro Lys Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys 
    130                 135                 140                 


Thr Ala Glu Leu Leu Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys 
145                 150                 155                 160 


Asn Phe Val Lys Lys Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu 
                165                 170                 175     


Asp Leu Arg Ser Phe Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln 
            180                 185                 190         


Met Val Met Lys Met Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val 
        195                 200                 205             


Asp Ile Glu Thr Pro Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys 
    210                 215                 220                 


Glu Phe Leu Val Pro Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro 
225                 230                 235                 240 


Gln Ser Pro Gln Gln Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp 
                245                 250                 255     


Arg Tyr Phe Gln Val Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro 
            260                 265                 270         


Asp Arg Gln Pro Glu Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val 
        275                 280                 285             


Asp Gln Thr Gly Ile Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser 
    290                 295                 300                 


Trp Pro Asn Asp Lys Asp Pro Val Val Val Pro Phe Pro Thr Met Thr 
305                 310                 315                 320 


Phe Ala Glu Val Leu Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg 
                325                 330                 335     


Phe Gly Met Lys Ile Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu 
            340                 345                 350         


Ile Gly Phe Leu Gln Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys 
        355                 360                 365             


Ala Ile Cys Ile Pro Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile 
    370                 375                 380                 


Glu Ser Ile Arg Asn Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu 
385                 390                 395                 400 


Pro Val Phe Leu Asn Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn 
                405                 410                 415     


Phe Ile Met Glu Ser Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr 
            420                 425                 430         


Gln Glu Glu Asp Val Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala 
        435                 440                 445             


Cys Ser Leu Leu Gly Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Glu 
    450                 455                 460                 


Thr Arg Gly Val Val Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp 
465                 470                 475                 480 


Val Val Asp Phe Pro Leu Phe Leu Pro Lys Glu Glu Asn Pro Arg Glu 
                485                 490                 495     


Leu Glu Ser Ala His His Pro Phe Thr Ala Pro His Pro Ser Asp Ile 
            500                 505                 510         


His Leu Leu Tyr Thr Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp 
        515                 520                 525             


Leu Val Leu Asn Gly Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His 
    530                 535                 540                 


Asn Ala Glu Leu Gln Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp 
545                 550                 555                 560 


Val Lys Met Leu Ser His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro 
                565                 570                 575     


Pro His Gly Gly Ile Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val 
            580                 585                 590         


Thr Gly Ser Pro Ser Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe 
        595                 600                 605             


Arg Gly His Asp Leu Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu 
    610                 615                 620                 


Glu Leu Lys Pro Tyr His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys 
625                 630                 635                 640 


Ala Glu Arg Ala His 
                645 


<210>  677
<211>  1347
<212>  DNA
<213>  Homosapiens

<400>  677
ccacccccgg agctctcacc cctccagtgc cgacggtagc gaaagacttt cctccagggg     60

cttcctcact ggggaattgc cggaaagagc aaacaaaaaa ggcgctggtg taggctccaa    120

aataaacaca tctgaattca tgatggcatc gacagaggct cttattggat taaaagtttc    180

aaaacaaaca ataacgcttt ggaaaaaggg ttgaatgcac cctcaggcac gaccatggag    240

aaaggtggga acatacaatt ggagattcct gacttcagca actctgtcct gagccatcta    300

aaccagttgc gcatgcaggg ccgtctctgt gatattgtgg tcaatgtgca aggacaagct    360

tttcgggctc acaaagtggt gctggctgcc agctccccct atttccggga tcacatgtcc    420

ttgaatgaga tgagtacagt ctccatttca gtcatcaaga accctactgt ttttgaacag    480

ctcctttctt tctgttacac agggcggata tgcctgcaac tggcagatat catcagctac    540

ctaacagctg ccagttttct gcaaatgcag catattatag acaaatgtac acagatcctg    600

gagggcattc atttcaaaat taatgtggct gaggttgaag cagaattaag tcaaacaagg    660

acaaagcatc aagagagacc tccagagtct cacagggtta caccaaatct caaccgctcc    720

cttagcccac gacataatac cccaaaggga aaccggcgag gtcaggttag tgctgtgctg    780

gatatcagag agctaagtcc tcctgaggag tccaccagcc ctcagatcat tgaaccaagt    840

tctgatgtag agagccggga gcccattctt cggatcaacc gagcaggaca gtggtatgtg    900

gagacaggag tggcggaccg tgggggtcgg agtgatgatg aagttagagt tcttggagca    960

gtacacatca aaactgaaaa tctggaggag tggcttgggc ctgagaatca gccttctgga   1020

gaagatggga gtagtgcaga ggaagtaaca gccatggtga ttgataccac aggccatggt   1080

tctgtaggac aggaaaatta tactttaggg tcttcaggag ccaaggtggc tcggccaaca   1140

agcagtgaag ttgacagatt tagcccctcc ggcagtgttg ttcccttgac agagagacac   1200

agagccagaa gtgagtctcc tgggagaatg gatgagccta agcaacccag ctcccaggta   1260

tggagttgtg gatttagaac tgctttggtg gttggaggaa ttgctactgt gtatgaatag   1320

aaaataatga aaaaaaaaaa aaaaaaa                                       1347


<210>  678
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  678

Met Glu Lys Gly Gly Asn Ile Gln Leu Glu Ile Pro Asp Phe Ser Asn 
1               5                   10                  15      


Ser Val Leu Ser His Leu Asn Gln Leu Arg Met Gln Gly Arg Leu Cys 
            20                  25                  30          


Asp Ile Val Val Asn Val Gln Gly Gln Ala Phe Arg Ala His Lys Val 
        35                  40                  45              


Val Leu Ala Ala Ser Ser Pro Tyr Phe Arg Asp His Met Ser Leu Asn 
    50                  55                  60                  


Glu Met Ser Thr Val Ser Ile Ser Val Ile Lys Asn Pro Thr Val Phe 
65                  70                  75                  80  


Glu Gln Leu Leu Ser Phe Cys Tyr Thr Gly Arg Ile Cys Leu Gln Leu 
                85                  90                  95      


Ala Asp Ile Ile Ser Tyr Leu Thr Ala Ala Ser Phe Leu Gln Met Gln 
            100                 105                 110         


His Ile Ile Asp Lys Cys Thr Gln Ile Leu Glu Gly Ile His Phe Lys 
        115                 120                 125             


Ile Asn Val Ala Glu Val Glu Ala Glu Leu Ser Gln Thr Arg Thr Lys 
    130                 135                 140                 


His Gln Glu Arg Pro Pro Glu Ser His Arg Val Thr Pro Asn Leu Asn 
145                 150                 155                 160 


Arg Ser Leu Ser Pro Arg His Asn Thr Pro Lys Gly Asn Arg Arg Gly 
                165                 170                 175     


Gln Val Ser Ala Val Leu Asp Ile Arg Glu Leu Ser Pro Pro Glu Glu 
            180                 185                 190         


Ser Thr Ser Pro Gln Ile Ile Glu Pro Ser Ser Asp Val Glu Ser Arg 
        195                 200                 205             


Glu Pro Ile Leu Arg Ile Asn Arg Ala Gly Gln Trp Tyr Val Glu Thr 
    210                 215                 220                 


Gly Val Ala Asp Arg Gly Gly Arg Ser Asp Asp Glu Val Arg Val Leu 
225                 230                 235                 240 


Gly Ala Val His Ile Lys Thr Glu Asn Leu Glu Glu Trp Leu Gly Pro 
                245                 250                 255     


Glu Asn Gln Pro Ser Gly Glu Asp Gly Ser Ser Ala Glu Glu Val Thr 
            260                 265                 270         


Ala Met Val Ile Asp Thr Thr Gly His Gly Ser Val Gly Gln Glu Asn 
        275                 280                 285             


Tyr Thr Leu Gly Ser Ser Gly Ala Lys Val Ala Arg Pro Thr Ser Ser 
    290                 295                 300                 


Glu Val Asp Arg Phe Ser Pro Ser Gly Ser Val Val Pro Leu Thr Glu 
305                 310                 315                 320 


Arg His Arg Ala Arg Ser Glu Ser Pro Gly Arg Met Asp Glu Pro Lys 
                325                 330                 335     


Gln Pro Ser Ser Gln Val Trp Ser Cys Gly Phe Arg Thr Ala Leu Val 
            340                 345                 350         


Val Gly Gly Ile Ala Thr Val Tyr Glu 
        355                 360     


<210>  679
<211>  1559
<212>  DNA
<213>  Homosapiens

<400>  679
aaagaaccag ttttcaggcg gattgcctca gatcacacta tctccacttg cccagccctg     60

tggaagatta gcggccatgt attccaatgt gataggaact gtaacctctg gaaaaaggaa    120

ggtttatctt ttgtccttgc tgctcattgg cttctgggac tgcgtgacct gtcacgggag    180

ccctgtggac atctgcacag ccaagccgcg ggacattccc atgaatccca tgtgcattta    240

ccgctccccg gagaagaagg caactgagga tgagggctca gaacagaaga tcccggaggc    300

caccaaccgg cgtgtctggg aactgtccaa ggccaattcc cgctttgcta ccactttcta    360

tcagcacctg gcagattcca agaatgacaa tgataacatt ttcctgtcac ccctgagtat    420

ctccacggct tttgctatga ccaagctggg tgcctgtaat gacaccctcc agcaactgat    480

ggaggtattt aagtttgaca ccatatctga gaaaacatct gatcagatcc acttcttctt    540

tgccaaactg aactgccgac tctatcgaaa agccaacaaa tcctccaagt tagtatcagc    600

caatcgcctt tttggagaca aatcccttac cttcaatgag acctaccagg acatcagtga    660

gttggtatat ggagccaagc tccagcccct ggacttcaag gaaaatgcag agcaatccag    720

agcggccatc aacaaatggg tgtccaataa gaccgaaggc cgaatcaccg atgtcattcc    780

ctcggaagcc atcaatgagc tcactgttct ggtgctggtt aacaccattt acttcaaggg    840

cctgtggaag tcaaagttca gccctgagaa cacaaggaag gaactgttct acaaggctga    900

tggagagtcg tgttcagcat ctatgatgta ccaggaaggc aagttccgtt atcggcgcgt    960

ggctgaaggc acccaggtgc ttgagttgcc cttcaaaggt gatgacatca ccatggtcct   1020

catcttgccc aagcctgaga agagcctggc caaggtagag aaggaactca ccccagaggt   1080

gctgcaagag tggctggatg aattggagga gatgatgctg gtggtccaca tgccccgctt   1140

ccgcattgag gacggcttca gtttgaagga gcagctgcaa gacatgggcc ttgtcgatct   1200

gttcagccct gaaaagtcca aactcccagg tattgttgca gaaggccgag atgacctcta   1260

tgtctcagat gcattccata aggcatttct tgaggtaaat gaagaaggca gtgaagcagc   1320

tgcaagtacc gctgttgtga ttgctggccg ttcgctaaac cccaacaggg tgactttcaa   1380

ggccaacagg cctttcctgg tttttataag agaagttcct ctgaacacta ttatcttcat   1440

gggcagagta gccaaccctt gtgttaagta aaatgttctt attctttgca cctcttccta   1500

tttttggttt gtgaacagaa gtaaaaataa atacaaacta cttccatctc acattaaaa    1559


<210>  680
<211>  464
<212>  PRT
<213>  Homosapiens

<400>  680

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro 
        35                  40                  45              


Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu 
    50                  55                  60                  


Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val 
65                  70                  75                  80  


Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 
                85                  90                  95      


His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 
            100                 105                 110         


Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 
        115                 120                 125             


Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 
    130                 135                 140                 


Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys 
145                 150                 155                 160 


Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn 
                165                 170                 175     


Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp 
            180                 185                 190         


Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys 
        195                 200                 205             


Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 
    210                 215                 220                 


Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 
225                 230                 235                 240 


Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 
                245                 250                 255     


Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr 
            260                 265                 270         


Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly 
        275                 280                 285             


Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu 
    290                 295                 300                 


Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro 
305                 310                 315                 320 


Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu 
                325                 330                 335     


Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met 
            340                 345                 350         


Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 
        355                 360                 365             


Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 
    370                 375                 380                 


Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe 
385                 390                 395                 400 


His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala 
                405                 410                 415     


Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val 
            420                 425                 430         


Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro 
        435                 440                 445             


Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys 
    450                 455                 460                 


<210>  681
<211>  5431
<212>  DNA
<213>  Homosapiens

<400>  681
ctttttttca aagattttga ttccagtgga atctttgctt tagatttgtg tgtgtgtttg     60

tgttcgtgaa ttgtaactcc agaagcaatg cctgtacaag ctccacaatg gacggatttc    120

ctctcctgcc caatttgcac tcagactttc gacgaaacaa ttcgaaagcc catcagtttg    180

ggttgtggcc atactgtctg caagatgtgc ctgaataaac tccaccgcaa ggcttgccca    240

tttgaccaga ccactatcaa tacagacatt gagctcctcc ctgtgaactc agcattgctg    300

cagctcgtgg gtgctcaggt ccctgagcag cagcctatta ctttgtgtag tggggttgaa    360

gacacaaagc attatgagga agccaagaaa tgtgtagaag aattagcatt gtacttaaaa    420

ccgctcagca gtgctagagg agtgggtctg aacagcacta ctcagagtgt tctgagtcgc    480

ccaatgcaga ggaagcttgt gactctagtc cactgtcaac tagtagaaga agaaggcagg    540

attcgtgcca tgagggcagc tcgatcttta ggtgaacgaa cagttacaga gctcattctc    600

cagcaccaga atcctcagca actctcttcc aatctttggg cagcagtaag ggctagggga    660

tgccagttcc ttggaccagc aatgcaggag gaagctttaa agttggttct gctggcctta    720

gaagatggtt ctgctttgtc aagaaaagta ttggttctgt ttgtggtgca aagattggag    780

ccacggtttc ctcaagcctc taaaactagc attgggcatg ttgttcagct cctttataga    840

gcctcctgtt tcaaggtcac caaacgtgat gaagactctt ctttgatgca gctgaaagaa    900

gaatttagaa cctatgaagc tctgcggcga gaacatgact cccagatagt gcagattgct    960

atggaagcag gcttacgaat tgcaccggac cagtggtcct ctttgcttta tggagaccag   1020

tctcacaaat ctcatatgca gtccattatt gacaagttgc agactccagc ctcttttgca   1080

cagagtgttc aggaactaac aattgctctc cagcgaactg gagacccagc aaacttgaac   1140

cgactaagac cccatttgga gctgttagca aacattgacc ctagtccaga tgctcctcct   1200

cctacttggg aacagctgga aaatgggctg gttgctgtgc gtacagtggt acatgggctg   1260

gttgattata tccagaacca cagcaaaaaa ggagcagatc agcagcagcc tccacagcat   1320

agcaaataca aaacatacat gtgtcgagat atgaagcaga gaggaggatg ccctcgtggg   1380

gccagctgta catttgcaca ctcacaggag gaactggaaa aatttcgtaa aatgaataag   1440

cgcctggttc cgagaagacc cttgagtgcc tctttgggtc aacttaatga ggtgggcctg   1500

ccttcagcag ctatccttcc agatgaaggt gcagtggatc tccctagcag aaaacctcct   1560

gctctgccaa atggaattgt atcaacaggg aatacagtaa cacagcttat tccgcgaggg   1620

acagacccca gctatgattc tagtctgaaa ccaggaaaaa tagatcatct gagcagtagt   1680

gctcctggat cccctcctga cctgctagaa tctgttccta agagtatttc tgccttacct   1740

gtgaatccac attctatacc tccaaggggg ccagcagatc tgcctccaat gcctgttacc   1800

aaaccacttc agatggtacc tcgaggttct cagttatatc cagcacaaca gacggatgtt   1860

tattatcagg atcctcgagg agcagctccg ccatttgaac cagcacctta tcagcagggt   1920

atgtattata ctccaccacc acaatgtgtg tcccgctttg tccgacctcc accatctgct   1980

cctgaacctg ctcctcccta cttggatcat tatccaccct acctccaaga acgtgttgta   2040

aactctcagt atggcacaca gccacagcag tacccaccta tatacccatc tcactatgat   2100

ggccgtcgag tgtaccctgc tccgtcttac acaagagaag agatattccg agaaagccct   2160

atacccattg agattccacc tgcagcagta ccatcgtatg taccagaatc cagagaaaga   2220

taccaacaga tcgagagtta ctatccagtg gctcctcatc caactcagat cagaccttcg   2280

tacctcagag aacctcctta tagccggctt cctcctcctc cccagcctca tcctagtcta   2340

gatgaactac atcgccgacg aaaggaaata atggcccagc tagaggaaag aaaggttatc   2400

tctccacctc cttttgcacc ttcaccaacc ttgcctccta cctttcatcc ggaagaattt   2460

ttggatgaag acttgaaggt agctgggaaa tacaaaggaa atgattatag ccaatactct   2520

ccctggtcat gtgacaccat cggctcctac attggaacca aagatgcaaa acccaaagat   2580

gttgtggcag cagggagtgt ggaaatgatg aatgtggaga gtaaaggaat gagggaccag   2640

cgattagatc ttcagagaag agcagcagaa accagtgatg atgacctcat cccatttgga   2700

gaccgaccaa cagtgtctcg gtttggtgcc atctcacgaa cttccaaaac tatatatcag   2760

ggtgctggtc caatgcaggc tatggcacct cagggagctc ctacaaaatc tattaacatt   2820

tcagattata gtccatatgg aacccacggt ggctggggag cttctccata ttcacctcat   2880

caaaacatac cttctcaggg acacttcagt gagagggaga gaatatctat gtcagaagtg   2940

gccagtcatg gaaaacccct tccatctgct gagagagaac agctacgact agaattgcag   3000

caattgaacc atcagattag ccagcagacc cagctacgtg gactagaggc tgttagtaac   3060

aggctggtgt tgcagaggga ggcaaacacc ctggcaggcc agtcacagcc cccaccaccg   3120

ccacctccaa aatggcctgg gatgatctca agtgagcagt tgagcttgga actgcaccag   3180

gtggaaaggg aaatcgggaa gagaacacgg gaactgagta tggaaaacca gtgttctctg   3240

gacatgaaaa gcaaactgaa tacaagtaaa caagcagaaa atggacaacc agaaccacaa   3300

aacaaggttc cggctgagga ccttacattg acattcagtg atgtaccaaa tggatcagcc   3360

ttgacacaag agaatatcag cctcctatca aacaagacca gctctctgaa cctgtcagag   3420

gaccctgagg gaggagggga taataatgac tcccagagat caggagttac tcccagttct   3480

gctccttaaa atatgaggag tcctactttt atcttctgct cctaatcagt ttgtcgggca   3540

taggggtagg agaacgcata acttctaaac tttttctctt aagagcggtc agagaaatcc   3600

aggaaattca ccagaggcaa tgtgcacaaa caccactact aaaaacaaac cctgcacata   3660

gttcacatta atgcattttt ttaatttaaa gaaaaagaaa attagcagta tctgcaagca   3720

attcagatta aatttgtttt tgttctgtga atgaacttta ttttaataac tttggacgcc   3780

ttggatccag ggctttaaaa aaaaaagata ttatatatac actctgtttg attaattgta   3840

tgatcttaat gaagtaggtt ttcttgtatt ttggtattac atacccagtg tataatttgt   3900

ataattcctc acccccaatc cttatcaatt ctcaccaccc cataaactta aaacagacca   3960

aaaatgtcag ctttcagaga attctgtggt gcttgagaaa cagacagtac tagactgagt   4020

tattagaaaa tgtgcagcaa accaactttt cccagagctg ttatttggaa ttctttatcc   4080

ctttctagat cactagcttc attggatacg tatatttttc ttgacattga agctttttgt   4140

ttgtttggga gggttttatt tcttgttttt attttcaact tttcaaatag aattaccaat   4200

tttgaagtcc tcattttcat attaaggatc atttgcattc tcttaatata atcagaaagc   4260

tgattcagtg tttaattaga tttaaatgtt gatcaagaat taactgtaac ttactagcac   4320

tgaaaataca tgtttggtgt ttcgcctgcg ttcagctcat ggttggaaat ttgaagcagt   4380

gcttttcaaa ttaaactttt gctgacatca taggatgcta aaaaacaagg acaatcaact   4440

atgttttaaa actgcaacat ttgatttgaa cttaaaatga atagagccac attattttaa   4500

tggatgtttt gttttacttg tgaactgatt gagtcttaag gatagtttat gaattgatca   4560

cttgttgctc agaatcatta gtataagtag gtaggaaata gtttgaagtc atttttcata   4620

gacttaactg tccaatgttg caaatgtttc ttcatgaaaa tattgaaaag agtaaggttt   4680

tttttttttt taattctgct gcacatattc tgatgccatg tgtctgtgct taattaacta   4740

agaccctata aaacgtgttt agtggggact gtttgatata gttgccctct ccattcctct   4800

atttgcctga tttttttcag tttccctttc tgtattttac tactaaatta gaaagcactg   4860

gttatgtaat aagttactac attgctttgg ttgagtaaaa acaagagttt atatttttct   4920

tgtttcttat tttcttaacc cttaactcct gctgaggtca taacaacctc agtctaagct   4980

ctgtgtccat catactgtta acttaaacaa atgggtggtg ggggtgggaa gggtaataca   5040

gtcctgccat tgcctaccag taggagagtc caaacagaac actcttttga gtagcaatta   5100

tttaatttgc ccagtcaagg caccgtgttt atatactatt tcacattgaa tttgattatg   5160

ccctacagac ctggctggtc aaggatttga tatacacata ttggcttggg attcgagctt   5220

tcttttttat ttaaataaaa atttatatat atattatata tatacatata tacatagcta   5280

tatctgtata tatattgggt atgttttaag gattttttcg catgagcgca gctgttgcga   5340

taaattgacc gattgggagg tggtagaagc actgaatgaa ggtgaggctt tttttttttc   5400

cagttttctt atacatttgt cttctttttt t                                  5431


<210>  682
<211>  1133
<212>  PRT
<213>  Homosapiens

<400>  682

Met Pro Val Gln Ala Pro Gln Trp Thr Asp Phe Leu Ser Cys Pro Ile 
1               5                   10                  15      


Cys Thr Gln Thr Phe Asp Glu Thr Ile Arg Lys Pro Ile Ser Leu Gly 
            20                  25                  30          


Cys Gly His Thr Val Cys Lys Met Cys Leu Asn Lys Leu His Arg Lys 
        35                  40                  45              


Ala Cys Pro Phe Asp Gln Thr Thr Ile Asn Thr Asp Ile Glu Leu Leu 
    50                  55                  60                  


Pro Val Asn Ser Ala Leu Leu Gln Leu Val Gly Ala Gln Val Pro Glu 
65                  70                  75                  80  


Gln Gln Pro Ile Thr Leu Cys Ser Gly Val Glu Asp Thr Lys His Tyr 
                85                  90                  95      


Glu Glu Ala Lys Lys Cys Val Glu Glu Leu Ala Leu Tyr Leu Lys Pro 
            100                 105                 110         


Leu Ser Ser Ala Arg Gly Val Gly Leu Asn Ser Thr Thr Gln Ser Val 
        115                 120                 125             


Leu Ser Arg Pro Met Gln Arg Lys Leu Val Thr Leu Val His Cys Gln 
    130                 135                 140                 


Leu Val Glu Glu Glu Gly Arg Ile Arg Ala Met Arg Ala Ala Arg Ser 
145                 150                 155                 160 


Leu Gly Glu Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln Asn Pro 
                165                 170                 175     


Gln Gln Leu Ser Ser Asn Leu Trp Ala Ala Val Arg Ala Arg Gly Cys 
            180                 185                 190         


Gln Phe Leu Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu Val Leu 
        195                 200                 205             


Leu Ala Leu Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu Val Leu 
    210                 215                 220                 


Phe Val Val Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser Lys Thr 
225                 230                 235                 240 


Ser Ile Gly His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys Phe Lys 
                245                 250                 255     


Val Thr Lys Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys Glu Glu 
            260                 265                 270         


Phe Arg Thr Tyr Glu Ala Leu Arg Arg Glu His Asp Ser Gln Ile Val 
        275                 280                 285             


Gln Ile Ala Met Glu Ala Gly Leu Arg Ile Ala Pro Asp Gln Trp Ser 
    290                 295                 300                 


Ser Leu Leu Tyr Gly Asp Gln Ser His Lys Ser His Met Gln Ser Ile 
305                 310                 315                 320 


Ile Asp Lys Leu Gln Thr Pro Ala Ser Phe Ala Gln Ser Val Gln Glu 
                325                 330                 335     


Leu Thr Ile Ala Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg 
            340                 345                 350         


Leu Arg Pro His Leu Glu Leu Leu Ala Asn Ile Asp Pro Ser Pro Asp 
        355                 360                 365             


Ala Pro Pro Pro Thr Trp Glu Gln Leu Glu Asn Gly Leu Val Ala Val 
    370                 375                 380                 


Arg Thr Val Val His Gly Leu Val Asp Tyr Ile Gln Asn His Ser Lys 
385                 390                 395                 400 


Lys Gly Ala Asp Gln Gln Gln Pro Pro Gln His Ser Lys Tyr Lys Thr 
                405                 410                 415     


Tyr Met Cys Arg Asp Met Lys Gln Arg Gly Gly Cys Pro Arg Gly Ala 
            420                 425                 430         


Ser Cys Thr Phe Ala His Ser Gln Glu Glu Leu Glu Lys Phe Arg Lys 
        435                 440                 445             


Met Asn Lys Arg Leu Val Pro Arg Arg Pro Leu Ser Ala Ser Leu Gly 
    450                 455                 460                 


Gln Leu Asn Glu Val Gly Leu Pro Ser Ala Ala Ile Leu Pro Asp Glu 
465                 470                 475                 480 


Gly Ala Val Asp Leu Pro Ser Arg Lys Pro Pro Ala Leu Pro Asn Gly 
                485                 490                 495     


Ile Val Ser Thr Gly Asn Thr Val Thr Gln Leu Ile Pro Arg Gly Thr 
            500                 505                 510         


Asp Pro Ser Tyr Asp Ser Ser Leu Lys Pro Gly Lys Ile Asp His Leu 
        515                 520                 525             


Ser Ser Ser Ala Pro Gly Ser Pro Pro Asp Leu Leu Glu Ser Val Pro 
    530                 535                 540                 


Lys Ser Ile Ser Ala Leu Pro Val Asn Pro His Ser Ile Pro Pro Arg 
545                 550                 555                 560 


Gly Pro Ala Asp Leu Pro Pro Met Pro Val Thr Lys Pro Leu Gln Met 
                565                 570                 575     


Val Pro Arg Gly Ser Gln Leu Tyr Pro Ala Gln Gln Thr Asp Val Tyr 
            580                 585                 590         


Tyr Gln Asp Pro Arg Gly Ala Ala Pro Pro Phe Glu Pro Ala Pro Tyr 
        595                 600                 605             


Gln Gln Gly Met Tyr Tyr Thr Pro Pro Pro Gln Cys Val Ser Arg Phe 
    610                 615                 620                 


Val Arg Pro Pro Pro Ser Ala Pro Glu Pro Ala Pro Pro Tyr Leu Asp 
625                 630                 635                 640 


His Tyr Pro Pro Tyr Leu Gln Glu Arg Val Val Asn Ser Gln Tyr Gly 
                645                 650                 655     


Thr Gln Pro Gln Gln Tyr Pro Pro Ile Tyr Pro Ser His Tyr Asp Gly 
            660                 665                 670         


Arg Arg Val Tyr Pro Ala Pro Ser Tyr Thr Arg Glu Glu Ile Phe Arg 
        675                 680                 685             


Glu Ser Pro Ile Pro Ile Glu Ile Pro Pro Ala Ala Val Pro Ser Tyr 
    690                 695                 700                 


Val Pro Glu Ser Arg Glu Arg Tyr Gln Gln Ile Glu Ser Tyr Tyr Pro 
705                 710                 715                 720 


Val Ala Pro His Pro Thr Gln Ile Arg Pro Ser Tyr Leu Arg Glu Pro 
                725                 730                 735     


Pro Tyr Ser Arg Leu Pro Pro Pro Pro Gln Pro His Pro Ser Leu Asp 
            740                 745                 750         


Glu Leu His Arg Arg Arg Lys Glu Ile Met Ala Gln Leu Glu Glu Arg 
        755                 760                 765             


Lys Val Ile Ser Pro Pro Pro Phe Ala Pro Ser Pro Thr Leu Pro Pro 
    770                 775                 780                 


Thr Phe His Pro Glu Glu Phe Leu Asp Glu Asp Leu Lys Val Ala Gly 
785                 790                 795                 800 


Lys Tyr Lys Gly Asn Asp Tyr Ser Gln Tyr Ser Pro Trp Ser Cys Asp 
                805                 810                 815     


Thr Ile Gly Ser Tyr Ile Gly Thr Lys Asp Ala Lys Pro Lys Asp Val 
            820                 825                 830         


Val Ala Ala Gly Ser Val Glu Met Met Asn Val Glu Ser Lys Gly Met 
        835                 840                 845             


Arg Asp Gln Arg Leu Asp Leu Gln Arg Arg Ala Ala Glu Thr Ser Asp 
    850                 855                 860                 


Asp Asp Leu Ile Pro Phe Gly Asp Arg Pro Thr Val Ser Arg Phe Gly 
865                 870                 875                 880 


Ala Ile Ser Arg Thr Ser Lys Thr Ile Tyr Gln Gly Ala Gly Pro Met 
                885                 890                 895     


Gln Ala Met Ala Pro Gln Gly Ala Pro Thr Lys Ser Ile Asn Ile Ser 
            900                 905                 910         


Asp Tyr Ser Pro Tyr Gly Thr His Gly Gly Trp Gly Ala Ser Pro Tyr 
        915                 920                 925             


Ser Pro His Gln Asn Ile Pro Ser Gln Gly His Phe Ser Glu Arg Glu 
    930                 935                 940                 


Arg Ile Ser Met Ser Glu Val Ala Ser His Gly Lys Pro Leu Pro Ser 
945                 950                 955                 960 


Ala Glu Arg Glu Gln Leu Arg Leu Glu Leu Gln Gln Leu Asn His Gln 
                965                 970                 975     


Ile Ser Gln Gln Thr Gln Leu Arg Gly Leu Glu Ala Val Ser Asn Arg 
            980                 985                 990         


Leu Val Leu Gln Arg Glu Ala Asn  Thr Leu Ala Gly Gln  Ser Gln Pro 
        995                 1000                 1005             


Pro Pro  Pro Pro Pro Pro Lys  Trp Pro Gly Met Ile  Ser Ser Glu 
    1010                 1015                 1020             


Gln Leu  Ser Leu Glu Leu His  Gln Val Glu Arg Glu  Ile Gly Lys 
    1025                 1030                 1035             


Arg Thr  Arg Glu Leu Ser Met  Glu Asn Gln Cys Ser  Leu Asp Met 
    1040                 1045                 1050             


Lys Ser  Lys Leu Asn Thr Ser  Lys Gln Ala Glu Asn  Gly Gln Pro 
    1055                 1060                 1065             


Glu Pro  Gln Asn Lys Val Pro  Ala Glu Asp Leu Thr  Leu Thr Phe 
    1070                 1075                 1080             


Ser Asp  Val Pro Asn Gly Ser  Ala Leu Thr Gln Glu  Asn Ile Ser 
    1085                 1090                 1095             


Leu Leu  Ser Asn Lys Thr Ser  Ser Leu Asn Leu Ser  Glu Asp Pro 
    1100                 1105                 1110             


Glu Gly  Gly Gly Asp Asn Asn  Asp Ser Gln Arg Ser  Gly Val Thr 
    1115                 1120                 1125             


Pro Ser  Ser Ala Pro 
    1130             


<210>  683
<211>  6259
<212>  DNA
<213>  Homosapiens

<400>  683
atgaattgtc tgaagggacc tcccattccc caaaaccaaa acggcacctt ttccacaagg     60

gacaagaaac ttttaaagag tcgcaaggtt agatttcagg agcccttcta tgggccatat    120

cttttcctgt cgtccccaaa tagctcttat tgttcacaca gcccaggaga gacgttttgg    180

agtagcgtgt ccgggccttt tgggctgttt cacagcctta ggaggctgaa ctcccagagg    240

ggtgacgagg acaaagctga tgagatccag aacctggata atatggaaga agaaaaatgg    300

gtctccgggg cgggccggag cctgaggaag aggaagggga cgaggacaac gagcgactgg    360

gcggcggagg acgaggagga ggaagaggag gccgagcaac aagatggccc ctgctgcagg    420

agcagcctca gcagcagcag gtgggaggcc ggaggcggtg ctggcggtgg cggcggcagc    480

cgtggcccgg cggcctggga cagaatcaga gtcaacggtg gcctcggcgg cggcggcggc    540

tgccgcggcg gtggcgacgg ccgcggggac tcggagctga gaggagctgc tgctcggacc    600

agcgcggtga gcgagcggcg ggcggcgact tggggagcgg ggctgccgcg gccggggcct    660

cagtcgggaa caataggcag ctgtggtcgg gaagggtttg tcctcgcccg ccctctgctc    720

ctccgcggca gcggcagccc ggccggcccc aggctcctca gggcccccgc cggctgttct    780

ggggcttgtc agtggccggc gtcctttagg cctcaggcct ctgcatgccg cctgtagggc    840

ctgtcggggt aggtaggccg agaggaggac gaagggaggc tcggacgaga gggagggggc    900

gaaagggcta cctggctcct gtggtactcc cagggcctgg gccaggcggg gaatgcgcac    960

gggaactgct ttttggaccc ctagtctgtg ggggtggggg agggcgaagg cgtctgtaaa   1020

caggcgccgc ctcggcctcc cagcacctca gggctgcttc ctcccccagc ccctgaagcg   1080

ctccccttct ttggccaagt ggatttcacg gtgtctgttt ccctgaagtc cctggagatc   1140

tagcctggta gtcttctccc tgctggcgat gggaaaattg tgtgtgtgca ggtgtcttta   1200

aaaaaaaaaa acaaaaaact taaatgcaac aaaaacatat aaaatgtggt tatcggtaaa   1260

ggatggagtg gtaagggatg cgcctctcta aacatctcta agtatcagtt ctataaacat   1320

cagttatgcc cgcatcccag gtgagagtgg attgaaacaa gggctctttt ggaacagtaa   1380

taacacaact cttgacatac cagaatagcc tatgaaactg gaaacaaaca ctggcaacgc   1440

ggagacaaac tgtaatgttt aaagaggact tttattccag ctaggcgttt tgaattacta   1500

acatgcagta taagaagcaa cattaactag cataaagtgg acctcaggaa gcacttcgaa   1560

aggagacagg tggttcatct ccggccatag agcttcttgt gccttgtctc gtgtttcagt   1620

aatttttcct gaaattgttc aagaccagtc ttttctctga gtttgaaatt tgatttcgtt   1680

tttgttttgt tttgcgacgg agtcttgctc tgtcacccag gctggattgc agtggcacaa   1740

tctcggctca ctacagcctc cacctcccgg attcaagcga ttctcctgcc tcaccatccg   1800

gagtagctgg gattacaggc gcccgccacc atgcccggct gatttttgta tttttagtag   1860

agacggggtt tcaccatgtt ggccaggctg gtctggaact cctgacctca agtcatctgc   1920

cctcctccgc ctcccaaagt gcttggatta caggcgtgag ccacctcgct cagccttaaa   1980

cttaattttt caaggcttct accacatttt cttacaagtg agggaaaagg tagatttatt   2040

tctaaagtac tttctaccta ggtatgcaga aatttatatt aaaatcgctt ggatacatcc   2100

aaggagattg cttttcactt gttaacattc aactgcaagg cctaagggtt ataggttgtg   2160

ttcttttcag cactgacctg tgctgaaaag atgccagtta atatctttca cctcttctaa   2220

gggtaaattt ctaagtagaa ttggtccaag tctgttctaa ttaaaaacat tataagcagc   2280

actagtctag ttcttagttc ttccacaaca attgacactg aatagattag caattgaata   2340

aacataaagg ttgaattttc ttgtttagga tttgaagtat agtgaatgaa tatcaatact   2400

gaccttcatt ttatgcttag cataaataat gttggagatg ttttgatttt ttgaatgatg   2460

gagaaataac aactttctat ggctcctgat gttgtgactt ttttgcagat atttcagaaa   2520

ggacaccgtt tttcaggtgc tcaaatctgt gatttttttt ttttttctgt gctaattttg   2580

ttaggtcagc acagattcca agtaaagtct gtgttataat gatacttaaa tttatgtatg   2640

gccctaaacc tattagaaca attgtagtaa tttataggtt gtaagtttta agtggttcat   2700

gtgctgtgtt atgaaaacaa tctcaccgtg ttatgtcaag ggcagattta cctcatattt   2760

aatatcattt tcctgaaaat aaatattttt aagtggtaag gttttgtatt tcagattggt   2820

tattgaccca gcaatttatg ggcttagtct gggtccgtat ttctgttcaa taggaaaaaa   2880

atttagggaa ttgtttttat ttattttgtg tcaaaacagt tttaagtttt gacacaaact   2940

caactgtccc ttcttcagta tcaatactta ttacttaagt tcacattttc tcaggtaata   3000

aaaatttact tctaagaagt tttggaacca gagcttaaga attagattta tattttcttg   3060

gtaatattaa aagttaatat atgcttgatt tatttgaaga aataaaaaag ggtaatttgt   3120

acacaacgcc tttcagaaca tatttgttga atgaataaaa atatttaagc ttcctcatta   3180

tgctgcagta ttagttctgt tgtcctcatt ttttcatatg aagaatgtga agctaagagt   3240

agctatgtaa ccagcaaaaa gatcacataa ttaataggta aaagagctta ctcagactca   3300

gatcttgtga cacaaattag attctttgcc actaccacat gtgtcacagt taaactttga   3360

agcatcttct gtgttgacag attccttttt ttgcctgtga acttacccta ttatcattat   3420

ttgtatcctg tcagatatct acttgtaaga ccaagaaagt atttgttcat gtgaatcaca   3480

aaagaaacac ttaaattttt gtttttagca tatctgaatg ctataaaata taaaaactca   3540

tactgtttac ataggacaga tttatcatac tgctgtaatt gttttcatgg ttaatttgtt   3600

acataggcaa ttactaaatt gtgcctttga aatactttat aaattttttt aaataattaa   3660

agatattcaa tgatgttaaa gttgggtcag ctaatatttg aagttcttaa tttataattt   3720

tttttcttta agccatagat aatttagaat tctgcagtat ttttcatctc cagatcttag   3780

ggcttgaaat ggattctgat gggtctaatc agtccactct tgcatatatc ttgaaaatgg   3840

tcagcatcca acaaagtgaa gaataaactg ataaatgatc cctgtttggt gaacacctca   3900

gatcaggatg ttccttggca gggtattctg acctggttta gctttggccc cgtctgtgct   3960

cagggttcag gtattctgca ggattgggtt cagagggatt aaaattctca gattggcctg   4020

tatcaaaaca gtcacagatt ttggtcagcc ttttcccaga accgtctcca agattttttc   4080

ttttgtgtaa ttctggaatc taggctggat ttggactagc tttagaggtt atgataaaag   4140

attaattttg tcaggcattt atacaaagga ggttttctta ctacagagtt tcttaaggta   4200

gattccttct atttttgaag tgtgacattt accaatctga agtaatgttg ccctacatcc   4260

cccagacact taactttagc atatttattt ctgtccattt ttggtcagga ttgtgcctgt   4320

ttacttatat aatattcttg tttacttttt gtttattaga tacttcttat tagtttatat   4380

tgttttcctg attgaggctt ggggaaagaa ttttcctcaa atttaaagtc accttactta   4440

tttgcagatg tatgtcagag caatattctt ttgacagtta tcaagcattt tagcaatgct   4500

gtatgtatat attatgaatg aatgacagag tcactcatgg tctgtcaccc aggctggagt   4560

gcagtggcat tatcatagct cacttcagcc tcaaactcct tggtttaagt gttattcccg   4620

ccttacctgg ctactttttt taatttttat tatttttata gagatagcat tttgctgtgt   4680

tgcccagggt ggtctcaaac tcctgggagc aaggtgatcc tcccacttct gcctcccaaa   4740

gtgctgagat tacaggcata acaatgtttt aaactgacac tggtatacct tcactgatta   4800

ttactgtgca catgtggtaa taatttaact tataagtgca ttttatctaa aaaatttcca   4860

agatctaaat agcatttgaa catggtagca gttttttttt tttttttttt ttttttttga   4920

gcaagaaaag agttctaaag gggtcagttt tatctacaga ttaacataat tttttttatt   4980

gaggttaagt cacataacat taaccatttt aaagtaaaca gtttaggtgg cactttatac   5040

attcacaatg ttgttcaacc accagctcta attccagaat gtgttcatta ccccaaaagg   5100

aaacactgta cccattaagc agttactctg tattcccctc ttccctaatc cctagcaaac   5160

gccattctgc tttctgtctc taatttgagc caacatcgag gaagagtact ctgtacaatt   5220

gaaattgcag aaaaaacttt gggatgtgat tgttaggaat aaaaaaccac ctaattcttt   5280

gcatgcttct ctaagtacag tagacatgct gccagggact ctttatggaa gaaaagttga   5340

gactcataga agtttgcagt tttgttttga tcaccccaga gggttttgct caaactctta   5400

gactcatttg tatttcttca ttgggttata agaactaaaa tttaatgttc tatacaaatg   5460

tgaacaacta atacttggtc tcctatctag aacttgtttg ccttttaggt tttcttaatg   5520

tatagaagaa actaggaata ttcacaaagg atttatttga agttacactg ggaaacgatt   5580

tttagaattt gaagctcttt gatccctgtg aatctaactt tatgactatt ttattcagct   5640

aatctttgag aatatttaga gttttgattt gcgtggcact ctgcttttaa tcccttgttg   5700

aataagtgtt agaaaccttg atcttggccc tatacctgat cacctctaaa aacatgaaca   5760

gtgttacaaa ggcagttgtt tagtaagctt ttttggattg ttttaattgg ctgactgagg   5820

gagacaaaat tagttttttt ttttctttct agaataaagg gtaataaact tggactttag   5880

agttactgct aagattgaca tttccatttg gggctttaga aatatattgt tatcttaaat   5940

tcaaaatggt actttatcta attgaattga aatcttaaaa tttatgagaa acaaaagtca   6000

ctttatgttc ttagtaaata tttctaatgg ggttatagga gatctaagta caaaaaaaat   6060

ttaaaatttt gttattaatc tcccctcctt aaggaaaatt ttattaatat acataattat   6120

aatttagtta taagaacaac ttaagttgag tacagtggct caagcctgta atcctagcac   6180

tttaggaggc caaggcagga ggatctcatg aagccaggag ttccagacca gcctgggcaa   6240

tagagtgaaa ccccacctc                                                6259


<210>  684
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  684

Met Asn Cys Leu Lys Gly Pro Pro Ile Pro Gln Asn Gln Asn Gly Thr 
1               5                   10                  15      


Phe Ser Thr Arg Asp Lys Lys Leu Leu Lys Ser Arg Lys Val Arg Phe 
            20                  25                  30          


Gln Glu Pro Phe Tyr Gly Pro Tyr Leu Phe Leu Ser Ser Pro Asn Ser 
        35                  40                  45              


Ser Tyr Cys Ser His Ser Pro Gly Glu Thr Phe Trp Ser Ser Val Ser 
    50                  55                  60                  


Gly Pro Phe Gly Leu Phe His Ser Leu Arg Arg Leu Asn Ser Gln Arg 
65                  70                  75                  80  


Gly Asp Glu Asp Lys Ala Asp Glu Ile Gln Asn Leu Asp Asn Met Glu 
                85                  90                  95      


Glu Glu Lys Trp Val Ser Gly Ala Gly Arg Ser Leu Arg Lys Arg Lys 
            100                 105                 110         


Gly Thr Arg Thr Thr Ser Asp Trp Ala Ala Glu Asp Glu Glu Glu Glu 
        115                 120                 125             


Glu Glu Ala Glu Gln Gln Asp Gly Pro Cys Cys Arg Ser Ser Leu Ser 
    130                 135                 140                 


Ser Ser Arg Trp Glu Ala Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Arg Gly Pro Ala Ala Trp Asp Arg Ile Arg Val Asn Gly Gly Leu Gly 
                165                 170                 175     


Gly Gly Gly Gly Cys Arg Gly Gly Gly Asp Gly Arg Gly Asp Ser Glu 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Arg Thr Ser Ala Val Ser Glu Arg Arg Ala 
        195                 200                 205             


Ala Thr Trp Gly Ala Gly Leu Pro Arg Pro Gly Pro Gln Ser Gly Thr 
    210                 215                 220                 


Ile Gly Ser Cys Gly Arg Glu Gly Phe Val Leu Ala Arg Pro Leu Leu 
225                 230                 235                 240 


Leu Arg Gly Ser Gly Ser Pro Ala Gly Pro Arg Leu Leu Arg Ala Pro 
                245                 250                 255     


Ala Gly Cys Ser Gly Ala Cys Gln Trp Pro Ala Ser Phe Arg Pro Gln 
            260                 265                 270         


Ala Ser Ala Cys Arg Leu 
        275             


<210>  685
<211>  5601
<212>  DNA
<213>  Homosapiens

<400>  685
ggcccggctg cgaggaggag gcggcggcgg cgcaggagga tgtacttggt ggcgggggac     60

agggggttgg ccggctgcgg gcacctcctg gtctcgctgc tggggctgct gctgctgctg    120

gcgcgctccg gcacccgggc gctggtctgc ctgccctgtg acgagtccaa gtgcgaggag    180

cccaggaact gcccggggag catcgtgcag ggcgtctgcg gctgctgcta cacgtgcgcc    240

agccagagga acgagagctg cggcggcacc ttcgggattt acggaacctg cgaccggggg    300

ctgcgttgtg tcatccgccc cccgctcaat ggcgactccc tcaccgagta cgaagcgggc    360

gtttgcgaag atgagaactg gactgatgac caactgcttg gttttaaacc atgcaatgaa    420

aaccttattg ctggctgcaa tataatcaat gggaaatgtg aatgtaacac cattcgaacc    480

tgcagcaatc cctttgagtt tccaagtcag gatatgtgcc tttcagcttt aaagagaatt    540

gaagaagaga agccagattg ctccaaggcc cgctgtgaag tccagttctc tccacgttgt    600

cctgaagatt ctgttctgat cgagggttat gctcctcctg gggagtgctg tcccttaccc    660

agccgctgcg tgtgcaaccc cgcaggctgt ctgcgcaaag tctgccagcc gggaaacctg    720

aacatactag tgtcaaaagc ctcagggaag ccgggagagt gctgtgacct ctatgagtgc    780

aaaccagttt tcggcgtgga ctgcaggact gtggaatgcc ctcctgttca gcagaccgcg    840

tgtcccccgg acagctatga aactcaagtc agactaactg cagatggttg ctgtactttg    900

ccaacaagat gcgagtgtct ctctggctta tgtggtttcc ccgtgtgtga ggtgggatcc    960

actccccgca tagtctctcg tggcgatggg acacctggaa agtgctgtga tgtctttgaa   1020

tgtgttaatg atacaaagcc agcctgcgta tttaacaatg tggaatatta tgatggagac   1080

atgtttcgaa tggacaactg tcggttctgt cgatgccaag ggggcgttgc catctgcttc   1140

actgcccagt gtggtgagat aaactgcgag aggtactacg tgcccgaagg agagtgctgc   1200

ccagtgtgtg aagatccagt gtatcctttt aataatcccg ctggctgcta tgccaatggc   1260

ctgatccttg cccacggaga ccggtggcgg gaagacgact gcacattctg ccagtgcgtc   1320

aacggtgaac gccactgcgt tgcgaccgtc tgcggacaga cctgcacaaa ccctgtgaaa   1380

gtgcctgggg agtgttgccc tgtgtgcgaa gaaccaacca tcatcacagt tgatccacct   1440

gcatgtgggg agttatcaaa ctgcactctg acagggaagg actgcattaa tggtttcaaa   1500

cgcgatcaca atggttgtcg gacctgtcag tgcataaaca ccgaggaact atgttcagaa   1560

cgtaaacaag gctgcacctt gaactgtccc ttcggtttcc ttactgatgc ccaaaactgt   1620

gagatctgtg agtgccgccc aaggcccaag aagtgcagac ccataatctg tgacaagtat   1680

tgtccacttg gattgctgaa gaataagcac ggctgtgaca tctgtcgctg taagaaatgt   1740

ccagagctct catgcagtaa gatctgcccc ttgggtttcc agcaggacag tcacggctgt   1800

cttatctgca agtgcagaga ggcctctgct tcagctgggc cacccatcct gtcgggcact   1860

tgtctcaccg tggatggtca tcatcataaa aatgaggaga gctggcacga tgggtgccgg   1920

gaatgctact gtctcaatgg acgggaaatg tgtgccctga tcacctgccc ggtgcctgcc   1980

tgtggcaacc ccaccattca ccctggacag tgctgcccat catgtgcaga tgactttgtg   2040

gtgcagaagc cagagctcag tactccctcc atttgccacg cccctggagg agaatacttt   2100

gtggaaggag aaacgtggaa cattgactcc tgtactcagt gcacctgcca cagcggacgg   2160

gtgctgtgtg agacagaggt gtgcccaccg ctgctctgcc agaacccctc acgcacccag   2220

gattcctgct gcccacagtg tacagatcaa ccttttcggc cttccttgtc ccgcaataac   2280

agcgtaccta attactgcaa aaatgatgaa ggggatatat tcctggcagc tgagtcctgg   2340

aagcctgacg tttgtaccag ctgcatctgc attgatagcg taattagctg tttctctgag   2400

tcctgccctt ctgtatcctg tgaaagacct gtcttgagaa aaggccagtg ttgtccctac   2460

tgcatagaag acacaattcc aaagaaggtg gtgtgccact tcagtgggaa ggcctatgcc   2520

gacgaggagc ggtgggacct tgacagctgc acccactgct actgcctgca gggccagacc   2580

ctctgctcga ccgtcagctg cccccctctg ccctgtgttg agcccatcaa cgtggaagga   2640

agttgctgcc caatgtgtcc agaaatgtat gtcccagaac caaccaatat acccattgag   2700

aagacaaacc atcgaggaga ggttgacctg gaggttcccc tgtggcccac gcctagtgaa   2760

aatgatatcg tccatctccc tagagatatg ggtcacctcc aggtagatta cagagataac   2820

aggctgcacc caagtgaaga ttcttcactg gactccattg cctcagttgt ggttcccata   2880

attatatgcc tctctattat aatagcattc ctattcatca atcagaagaa acagtggata   2940

ccactgcttt gctggtatcg aacaccaact aagccttctt ccttaaataa tcagctagta   3000

tctgtggact gcaagaaagg aaccagagtc caggtggaca gttcccagag aatgctaaga   3060

attgcagaac cagatgcaag attcagtggc ttctacagca tgcaaaaaca gaaccatcta   3120

caggcagaca atttctacca aacagtgtga agaaaggcaa ctaggatgag gtttcaaaag   3180

acggaagacg actaaatctg ctctaaaaag taaactagaa tttgtgcact tgcttagtgg   3240

attgtattgg attgtgactt gatgtacagc gctaagacct tactgggatg ggctctgtct   3300

acagcaatgt gcagaacaag cattcccact tttcctcaag ataactgacc aagtgttttc   3360

ttagaaccaa agtttttaaa gttgctaaga tatatttgcc tgtaagatag ctgtagagat   3420

atttggggtg gggacagtga gtttggatgg ggaaatgggt gggagggtgg tgttgggaag   3480

aaaaattggt cagcttggct cggggagaaa cctggtaaca taaaagcagt tcagtggccc   3540

agaggttatt tttttcctat tgctctgaag actgcactgg ttgctgcaaa gctcaggcct   3600

gaatgagcag gaaacaaaaa aggccttgcg acccagctgc cataaccacc ttagaactac   3660

cagacgagca catcagaacc ctttgacagc catcccaggt ctaaagccac aagtttcttt   3720

tctatacagt cacaactgca gtaggcagtg aggaagccag agaaatgcga tagcggcatt   3780

tctctaaagc gggttattaa ggatatatac agttacactt tttgctgctt ttattttctt   3840

ccaagccaat caatcagcca gttcctagca gagtcagcac atgaacaaga tctaagtcat   3900

ttcttgatgt gagcactgga gctttttttt ttttacaacg tgacaggaag aggagggaga   3960

gggtgacgaa caccaggcat ttccaggggc tatatttcac tgtttgttgt tgctttgttc   4020

tgttatattg ttggttgttc atagtttttg ttgaagctct agcttaagaa gaaacttttt   4080

ttaaaaagac tgtttgggga ttctttttcc ttattatata ctgattctac aaaatagaaa   4140

ctacttcatt ttaattgtat attattcaag cacctttgtt gaagctcaaa aaaaatgatg   4200

cctctttaaa ctttagcaat tataggagta tttatgtaac tatcttatgc ttcaaaaaac   4260

aaaagtattt gtgtgcatgt gtatataata tatatatata catatatatt tatacacata   4320

caatttatgt tttcctgttg aatgtatttt tatgagattt taaccagaac aaaggcagat   4380

aaacaggcat tccatagcag tgcttttgat cacttacaaa ttttttgaat aacacaaaat   4440

ctcattctac ctgcagttta attggaaaga tgtgtgtgtg agagtatgta tgtgtgtgtg   4500

tgtgtgtgtg tgtgtgcgcg cgcacgcacg ccttgagcag tcagcattgc acctgctatg   4560

gagaagggta ttcctttatt aaaatcttcc tcatttggat ttgctttcag ttggttttca   4620

atttgctcac tggccagaga cattgatggc agttcttatc tgcatcacta atcagctcct   4680

ggattttttt tttttttttt tcaaacaatg gtttgaaaca actactggaa tattgtccac   4740

aataagctgg aagtttgttg tagtatgcct caaatataac tgactgtata ctatagtggt   4800

aacttttcaa acagccctta gcacttttat actaattaac ccatttgtgc attgagtttt   4860

cttttaaaaa tgcttgttgt gaaagacaca gatacccagt atgcttaacg tgaaaagaaa   4920

atgtgttctg ttttgtaaag gaactttcaa gtattgttgt aaatacttgg acagaggttg   4980

ctgaacttta aaaaaaatta atttattatt ataatgacct aatttattaa tctgaagatt   5040

aaccattttt ttgtcttaga atatcaaaaa gaaaaagaaa aaggtgttct agctgtttgc   5100

atcaaaggaa aaaaagattt attatcaagg ggcaatattt ttatcttttc caaaataaat   5160

ttgttaatga tacattacaa aaatagattg acatcagcct gattagtata aattttgttg   5220

gtaattaatc cattcctggc ataaaaagtc tttatcaaaa aaaattgtag atgcttgctt   5280

tttgtttttt caatcatggc catattatga aaatactaac aggatatagg acaaggtgta   5340

aattttttta ttattatttt aaagatatga tttatcctga gtgctgtatc tattactctt   5400

ttactttggt tcctgttgtg ctcttgtaaa agaaaaatat aatttcctga agaataaaat   5460

agatatatgg cacttggagt gcatcatagt tctacagttt gtttttgttt tcttcaaaaa   5520

agctgtaaga gaattatctg caacttgatt cttggcagga aataaacatt ttgagttgaa   5580

atcaaaaaaa aaaaaaaaaa a                                             5601


<210>  686
<211>  1036
<212>  PRT
<213>  Homosapiens

<400>  686

Met Tyr Leu Val Ala Gly Asp Arg Gly Leu Ala Gly Cys Gly His Leu 
1               5                   10                  15      


Leu Val Ser Leu Leu Gly Leu Leu Leu Leu Leu Ala Arg Ser Gly Thr 
            20                  25                  30          


Arg Ala Leu Val Cys Leu Pro Cys Asp Glu Ser Lys Cys Glu Glu Pro 
        35                  40                  45              


Arg Asn Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr 
    50                  55                  60                  


Thr Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Thr Phe Gly Ile 
65                  70                  75                  80  


Tyr Gly Thr Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu 
                85                  90                  95      


Asn Gly Asp Ser Leu Thr Glu Tyr Glu Ala Gly Val Cys Glu Asp Glu 
            100                 105                 110         


Asn Trp Thr Asp Asp Gln Leu Leu Gly Phe Lys Pro Cys Asn Glu Asn 
        115                 120                 125             


Leu Ile Ala Gly Cys Asn Ile Ile Asn Gly Lys Cys Glu Cys Asn Thr 
    130                 135                 140                 


Ile Arg Thr Cys Ser Asn Pro Phe Glu Phe Pro Ser Gln Asp Met Cys 
145                 150                 155                 160 


Leu Ser Ala Leu Lys Arg Ile Glu Glu Glu Lys Pro Asp Cys Ser Lys 
                165                 170                 175     


Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro Glu Asp Ser Val 
            180                 185                 190         


Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys Pro Leu Pro Ser 
        195                 200                 205             


Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys Val Cys Gln Pro 
    210                 215                 220                 


Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly Lys Pro Gly Glu 
225                 230                 235                 240 


Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly Val Asp Cys Arg 
                245                 250                 255     


Thr Val Glu Cys Pro Pro Val Gln Gln Thr Ala Cys Pro Pro Asp Ser 
            260                 265                 270         


Tyr Glu Thr Gln Val Arg Leu Thr Ala Asp Gly Cys Cys Thr Leu Pro 
        275                 280                 285             


Thr Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe Pro Val Cys Glu 
    290                 295                 300                 


Val Gly Ser Thr Pro Arg Ile Val Ser Arg Gly Asp Gly Thr Pro Gly 
305                 310                 315                 320 


Lys Cys Cys Asp Val Phe Glu Cys Val Asn Asp Thr Lys Pro Ala Cys 
                325                 330                 335     


Val Phe Asn Asn Val Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met Asp 
            340                 345                 350         


Asn Cys Arg Phe Cys Arg Cys Gln Gly Gly Val Ala Ile Cys Phe Thr 
        355                 360                 365             


Ala Gln Cys Gly Glu Ile Asn Cys Glu Arg Tyr Tyr Val Pro Glu Gly 
    370                 375                 380                 


Glu Cys Cys Pro Val Cys Glu Asp Pro Val Tyr Pro Phe Asn Asn Pro 
385                 390                 395                 400 


Ala Gly Cys Tyr Ala Asn Gly Leu Ile Leu Ala His Gly Asp Arg Trp 
                405                 410                 415     


Arg Glu Asp Asp Cys Thr Phe Cys Gln Cys Val Asn Gly Glu Arg His 
            420                 425                 430         


Cys Val Ala Thr Val Cys Gly Gln Thr Cys Thr Asn Pro Val Lys Val 
        435                 440                 445             


Pro Gly Glu Cys Cys Pro Val Cys Glu Glu Pro Thr Ile Ile Thr Val 
    450                 455                 460                 


Asp Pro Pro Ala Cys Gly Glu Leu Ser Asn Cys Thr Leu Thr Gly Lys 
465                 470                 475                 480 


Asp Cys Ile Asn Gly Phe Lys Arg Asp His Asn Gly Cys Arg Thr Cys 
                485                 490                 495     


Gln Cys Ile Asn Thr Glu Glu Leu Cys Ser Glu Arg Lys Gln Gly Cys 
            500                 505                 510         


Thr Leu Asn Cys Pro Phe Gly Phe Leu Thr Asp Ala Gln Asn Cys Glu 
        515                 520                 525             


Ile Cys Glu Cys Arg Pro Arg Pro Lys Lys Cys Arg Pro Ile Ile Cys 
    530                 535                 540                 


Asp Lys Tyr Cys Pro Leu Gly Leu Leu Lys Asn Lys His Gly Cys Asp 
545                 550                 555                 560 


Ile Cys Arg Cys Lys Lys Cys Pro Glu Leu Ser Cys Ser Lys Ile Cys 
                565                 570                 575     


Pro Leu Gly Phe Gln Gln Asp Ser His Gly Cys Leu Ile Cys Lys Cys 
            580                 585                 590         


Arg Glu Ala Ser Ala Ser Ala Gly Pro Pro Ile Leu Ser Gly Thr Cys 
        595                 600                 605             


Leu Thr Val Asp Gly His His His Lys Asn Glu Glu Ser Trp His Asp 
    610                 615                 620                 


Gly Cys Arg Glu Cys Tyr Cys Leu Asn Gly Arg Glu Met Cys Ala Leu 
625                 630                 635                 640 


Ile Thr Cys Pro Val Pro Ala Cys Gly Asn Pro Thr Ile His Pro Gly 
                645                 650                 655     


Gln Cys Cys Pro Ser Cys Ala Asp Asp Phe Val Val Gln Lys Pro Glu 
            660                 665                 670         


Leu Ser Thr Pro Ser Ile Cys His Ala Pro Gly Gly Glu Tyr Phe Val 
        675                 680                 685             


Glu Gly Glu Thr Trp Asn Ile Asp Ser Cys Thr Gln Cys Thr Cys His 
    690                 695                 700                 


Ser Gly Arg Val Leu Cys Glu Thr Glu Val Cys Pro Pro Leu Leu Cys 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Thr Gln Asp Ser Cys Cys Pro Gln Cys Thr Asp 
                725                 730                 735     


Gln Pro Phe Arg Pro Ser Leu Ser Arg Asn Asn Ser Val Pro Asn Tyr 
            740                 745                 750         


Cys Lys Asn Asp Glu Gly Asp Ile Phe Leu Ala Ala Glu Ser Trp Lys 
        755                 760                 765             


Pro Asp Val Cys Thr Ser Cys Ile Cys Ile Asp Ser Val Ile Ser Cys 
    770                 775                 780                 


Phe Ser Glu Ser Cys Pro Ser Val Ser Cys Glu Arg Pro Val Leu Arg 
785                 790                 795                 800 


Lys Gly Gln Cys Cys Pro Tyr Cys Ile Glu Asp Thr Ile Pro Lys Lys 
                805                 810                 815     


Val Val Cys His Phe Ser Gly Lys Ala Tyr Ala Asp Glu Glu Arg Trp 
            820                 825                 830         


Asp Leu Asp Ser Cys Thr His Cys Tyr Cys Leu Gln Gly Gln Thr Leu 
        835                 840                 845             


Cys Ser Thr Val Ser Cys Pro Pro Leu Pro Cys Val Glu Pro Ile Asn 
    850                 855                 860                 


Val Glu Gly Ser Cys Cys Pro Met Cys Pro Glu Met Tyr Val Pro Glu 
865                 870                 875                 880 


Pro Thr Asn Ile Pro Ile Glu Lys Thr Asn His Arg Gly Glu Val Asp 
                885                 890                 895     


Leu Glu Val Pro Leu Trp Pro Thr Pro Ser Glu Asn Asp Ile Val His 
            900                 905                 910         


Leu Pro Arg Asp Met Gly His Leu Gln Val Asp Tyr Arg Asp Asn Arg 
        915                 920                 925             


Leu His Pro Ser Glu Asp Ser Ser Leu Asp Ser Ile Ala Ser Val Val 
    930                 935                 940                 


Val Pro Ile Ile Ile Cys Leu Ser Ile Ile Ile Ala Phe Leu Phe Ile 
945                 950                 955                 960 


Asn Gln Lys Lys Gln Trp Ile Pro Leu Leu Cys Trp Tyr Arg Thr Pro 
                965                 970                 975     


Thr Lys Pro Ser Ser Leu Asn Asn Gln Leu Val Ser Val Asp Cys Lys 
            980                 985                 990         


Lys Gly Thr Arg Val Gln Val Asp  Ser Ser Gln Arg Met  Leu Arg Ile 
        995                 1000                 1005             


Ala Glu  Pro Asp Ala Arg Phe  Ser Gly Phe Tyr Ser  Met Gln Lys 
    1010                 1015                 1020             


Gln Asn  His Leu Gln Ala Asp  Asn Phe Tyr Gln Thr  Val 
    1025                 1030                 1035     


<210>  687
<211>  1936
<212>  DNA
<213>  Homosapiens

<400>  687
ccggagcctc ctggaccagg agaactgtaa cgcgagcccc gagccatggg cgaaaggcgg     60

ggccgagacg ggttgggggc gccgacggtt tcccggccct ggctgcagct tggaggagaa    120

gctgagcctg tgcttccgcc cctcggatcc gggcgccgag cccgaggacg gccgtgcggc    180

catcacggag ctcaactcct gcagggggac gagatttgga atgccctgac agataattat    240

gggaatgtga tgcctgtaga ctggaagtca tcgcatacta ggaccttgca cttgcttact    300

ctgaacctct cagaaaaagg ggtaagtgac agtttgctct ttgatacatc agatgatgaa    360

gagctgagag aacagctgga tatgcactca atcatcgtct cctgtgttaa tgatgaaccc    420

ctcttcacgg cagaccaggt tattgaagaa attgaagaaa tgatgcagga atcaccggac    480

ccagaagatg atgaaacccc tacacagtca gatcggcttt caatgctttc ccaggaaatt    540

caaactctca agaggtctag taccggcagt tatgaagaga gagtgaaaag gctctcagtg    600

tctgagttaa atgaaatcct ggaagaaatt gagactgcca ttaaggagta ctctgaggag    660

ctggtgcagc agttggcttt acgagatgaa ctggagtttg aaaaggaagt gaaaaacagc    720

tttatttctg ttcttattga agtgcaaaac aaacagaaag agcacaaaga aacagcaaaa    780

aagaaaaaga aactaaaaaa tggcagctct cagaatggga agaatgagag aagtcatatg    840

cccggcacat atttgactac agtcattcct tatgagaaaa aaaacggacc accgtctgtt    900

gaagatcttc aaatattaac aaaaattctt cgtgccatga aggaggacag tgaaaaagtt    960

ccgagcttgt taactgatta tattctgaaa gttctgtgtc ctacatagag cagcaacttt   1020

atctgcggtg ggctccaagc tagatttccg acagcattat tctgagagct ggctaccatt   1080

acccttcttg ctattggaaa ctcagcacat ttgaacttgg gtttgattca gtattaacag   1140

atcttgacta cactaattct ttatattata gaaccaacgg aaatatgggc actattttga   1200

attctagaga tggtttttgt taaatctact aataaactgt tctcttagta gattaagaga   1260

gagtaatatt aattgtgcat gtgcagttgt atttctcatt aactgacagt atgcccattt   1320

gtttttatgg ctttcttatc taaactgcac tgatgaacta gattaaagcc ttgggagatt   1380

tatactataa attcagtgat ggcaagaacc aacactgttt ttttgtgaga attgtcagtg   1440

taactattac ctaccagtat tgttcagaga gattgaaaca gaataaacgg gctgttcttg   1500

aagaagcaaa accagaatat gcattacttt ggtttaatac ttagtgctaa cattgaaact   1560

gttggtggtg atggattttg tagcttgctg cttgtttcac cactggtcaa attttaacca   1620

ttaaattgcc attcactttt agaatcttgt atttaagtaa gttttgattt tcaaatgttc   1680

tgcttcatgt gtctgtgaag aattgtactt ttttaaaagt gtgtgtcctc tgaggtgctt   1740

gagaaagtgt acactgcaga actgcccatt ctcattactg tgtcctattt tattcatgcc   1800

tgtgtgtttt tcttaagtat gaattctaga tacagctact tatggattca tcaatatcat   1860

gagcactttt gctggttcca gtcaaatcaa tggcatttaa taaatttttt aagaagtaaa   1920

aaaaaaaaaa aaaaaa                                                   1936


<210>  688
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  688

Met Gly Glu Arg Arg Gly Arg Asp Gly Leu Gly Ala Pro Thr Val Ser 
1               5                   10                  15      


Arg Pro Trp Leu Gln Leu Gly Gly Glu Ala Glu Pro Val Leu Pro Pro 
            20                  25                  30          


Leu Gly Ser Gly Arg Arg Ala Arg Gly Arg Pro Cys Gly His His Gly 
        35                  40                  45              


Ala Gln Leu Leu Gln Gly Asp Glu Ile Trp Asn Ala Leu Thr Asp Asn 
    50                  55                  60                  


Tyr Gly Asn Val Met Pro Val Asp Trp Lys Ser Ser His Thr Arg Thr 
65                  70                  75                  80  


Leu His Leu Leu Thr Leu Asn Leu Ser Glu Lys Gly Val Ser Asp Ser 
                85                  90                  95      


Leu Leu Phe Asp Thr Ser Asp Asp Glu Glu Leu Arg Glu Gln Leu Asp 
            100                 105                 110         


Met His Ser Ile Ile Val Ser Cys Val Asn Asp Glu Pro Leu Phe Thr 
        115                 120                 125             


Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln Glu Ser Pro 
    130                 135                 140                 


Asp Pro Glu Asp Asp Glu Thr Pro Thr Gln Ser Asp Arg Leu Ser Met 
145                 150                 155                 160 


Leu Ser Gln Glu Ile Gln Thr Leu Lys Arg Ser Ser Thr Gly Ser Tyr 
                165                 170                 175     


Glu Glu Arg Val Lys Arg Leu Ser Val Ser Glu Leu Asn Glu Ile Leu 
            180                 185                 190         


Glu Glu Ile Glu Thr Ala Ile Lys Glu Tyr Ser Glu Glu Leu Val Gln 
        195                 200                 205             


Gln Leu Ala Leu Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys Asn 
    210                 215                 220                 


Ser Phe Ile Ser Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu His 
225                 230                 235                 240 


Lys Glu Thr Ala Lys Lys Lys Lys Lys Leu Lys Asn Gly Ser Ser Gln 
                245                 250                 255     


Asn Gly Lys Asn Glu Arg Ser His Met Pro Gly Thr Tyr Leu Thr Thr 
            260                 265                 270         


Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser Val Glu Asp Leu 
        275                 280                 285             


Gln Ile Leu Thr Lys Ile Leu Arg Ala Met Lys Glu Asp Ser Glu Lys 
    290                 295                 300                 


Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val Leu Cys Pro Thr 
305                 310                 315                 320 


<210>  689
<211>  4534
<212>  DNA
<213>  Homosapiens

<400>  689
atgctctttg agggcttgga tctggtgtcg gcgctggcca ccctcgccgc gtgcctggtg     60

tccgtgacgc tgctgctggc cgtgtcgcag cagctgtggc agctgcgctg ggccgccact    120

cgcgacaaga gctgcaagct gcccatcccc aagggatcca tgggcttccc gctcatcgga    180

gagaccggcc actggctgct gcagggttct ggcttccagt cgtcgcggag ggagaagtat    240

ggcaacgtgt tcaagacgca tttgttgggg cggccgctga tacgcgtgac cggcgcggag    300

aacgtgcgca agatcctcat gggcgagcac cacctcgtga gcaccgagtg gcctcgcagc    360

acccgcatgt tgctgggccc caacacggtg tccaattcca ttggcgacat ccaccgcaac    420

aagcgcaagg tcttctccaa gatcttcagc cacgaggccc tggagagtta cctgcccaag    480

atccagctgg tgatccagga cacactgcgc gcctggagca gccaccccga ggccatcaac    540

gtgtaccagg aggcgcagaa gctgaccttc cgcatggcca tccgggtgct gctgggcttc    600

agcatccctg aggaggacct tgggcacctc tttgaggtct accagcagtt tgtggacaat    660

gtcttctccc tgcctgtcga cctgcccttc agtggctacc ggcggggcat tcaggctcgg    720

cagatcctgc agaaggggct ggagaaggcc atccgggaga agctgcagtg cacacagggc    780

aaggactact tggacgccct ggacctcctc attgagagca gcaaggagca cgggaaggag    840

atgaccatgc aggagctgaa ggacgggacc ctggagctga tctttgcggc ctatgccacc    900

acggccagcg ccagcacctc actcatcatg cagctgctga agcaccccac tgtgctggag    960

aagctgcggg atgagctgcg ggctcatggc atcctgcaca gtggcggctg cccctgcgag   1020

ggcacactgc gcctggacac gctcagtggg ctgcgctacc tggactgcgt catcaaggag   1080

gtcatgcgcc tgttcacgcc catttccggc ggctaccgca ctgtgctgca gaccttcgag   1140

cttgatggtt tccagatccc caaaggctgg agtgtcatgt atagcatccg ggacacccat   1200

gacacagcgc ccgtgttcaa agacgtgaac gtgttcgacc ccgatcgctt cagccaggcg   1260

cggagcgagg acaaggatgg ccgcttccat tacctcccgt tcggtggcgg tgtccggacc   1320

tgcctgggca agcacctggc caagctgttc ctgaaggtgc tggcggtgga gctggctagc   1380

accagccgct ttgagctggc cacacggacc ttcccccgca tcaccttggt ccccgtcctg   1440

caccccgtgg atggcctcag cgtcaagttc tttggcctgg actccaacca gaacgagatc   1500

ctgccggaga cggaggccat gctgagcgcc acagtctaac ccaagaccca cccgcctcag   1560

cccagcccag gcagcggggt ggtggttgtg ggaggtagaa acctgtgtgt gggagggggc   1620

cggaacgggg agggcgagtg gcccccatac ttgccctccc ttgctccccc tccctggcaa   1680

accctaccca aagccagtgg gccccattcc tagggctggg ctccccttct ggctccagct   1740

tccctccagc cactccccat ttaccatcag ctcagcccct gggaagggcg tggcaggggc   1800

tctgcatgcc cgtgacagtg ttaggtgtca gcgcgtgcta cagtgttttt gtgatgttct   1860

gaactgctcc cttccctccg ttcctttcgg acccttttag ctggggttgg gggacgggaa   1920

gagccgtgcc cccttgggcg cactcttcag cgtctcctcc tcctgcgccc ccactgcgtc   1980

tgcccaggaa cagcatcctg ggtagcagaa caggagtcaa ccttggcggg gcgggggctg   2040

cgtccaacct ggagattgcc cttccctatg ccacggttcc caccctccct caccagtttg   2100

gacaatttga aattacctat tgctgctact tgttctgtcc tctgaccttg gggcaaagga   2160

gccccaggcc ctgtctcccc agcatcctcc ctggtggccc tgggcaggtg cactgacacc   2220

cccaccttcc catcccctgc tgaaccaggc cctgttacac acagccgcct aaggcccgcg   2280

gctcatgtgc tgcccgcccc catatttatt cactgataga gaatcttggg gatgctgggg   2340

tctggagtga acatctcctc cccttcatgc cctagcctgt gttctagctg tcctggcgag   2400

acttctgtga gtgaagagga aggggtctct ggtcaaaccc agcccccagg gcctagggtt   2460

gaaagccttc cccggctccg ggcattattt gggtttaatc tcggagcctc actcctggac   2520

tgaagtccgg tgcctctgcc ttatccctgg tggagatgga atgtggccca ttgcctcctc   2580

cctctcctgt caaaaaccct gatcaggtag atttggaggc ggccacgatt tcctgtttgg   2640

cccctgttca ccccagtgca ctggccctga ctccaggcgt gagtatgggg aaggatacgg   2700

gttcttctga cggggagcaa gggcctccgt cttcccttcc ttaactctcc ccctttgccc   2760

tccgccctga aaaaggtgtc cttgaagtcc cttccacctc tatgccactg tctgcttagc   2820

ccagctcagg ggtggggaag aggcgaaagc gtgggggagg tgagcgcagc ggcagttctg   2880

cctcggagct gattgcaggg ccctgtgtgg tctccggaca gctgcgggaa ggctgccgca   2940

gctgaagctg aagaggcggc tacgtgcggt ttgtcagggg gattgggttg aaaactggcc   3000

agtcgggatg actgggtgaa agaggagtag ctcctgccac tggcgttttg agtgttggca   3060

atttgggatg cctcctgggg aaggtttccg ggcgtttggt gagtctctag atttttcctt   3120

gctttctgtg tttattggtt tttgatgttg taaaagcaat gaatcccctt tacaagaaaa   3180

tcgaaaacac agaagaatga aggacatgcc agtccccgat cgctgctgtg agcacctcag   3240

tggctccctc agaccagatc ccgtaggcag ccccacagac cgaccctgac cccactcaca   3300

gccaccctga agatagacta taggaacggg cccataccac acagactgct ctccaatccc   3360

tgagtctcag atgtttcatt tatttcctac ttttccacta ctaaaaaaca gtgtggaata   3420

gacattattg gcaaaattgc tcatccctaa tcctgaaaaa caggccagaa tgggtaaaga   3480

cttgtcaaag cttgcaacat agctacatgg tgcacccgga cctgtacccc ctccccccaa   3540

cacaaaacca gtgtctggga ggttcatttt cctttaaact gatccagctg gccctgaacc   3600

aattgttttt gactgagtat ctaggagagc agtaagtgga acttcagaca agcccactgg   3660

gtctggtcca ggtgaggggc agggggcatg gggctgggag gtctcagggg ccttccctgg   3720

gggtggccag cctggtaggg ggcagagaag gaaaagctga ggggggtccc tgtgagggag   3780

gaaagaagga tcatttgccc cgctgggtct caaaggcagt gagaagagag ctgaagaaag   3840

ctctggctgg ctgacaggat ccctgtgttg taattggtcc ctcctttcag ctctctagtg   3900

agatgcccgt gtctgtgcgt gtgcgtgtgt gtttcataca gctagcatta gatgggtgat   3960

gtttcttact tatcatccct aactattgca acttgacctt aaaaagacaa aaccccacaa   4020

aactcttcct gccacgggct tgcagattga agcactttcg atgttgggcg ctggcgtttg   4080

tgttctgggc accaccgtga ccctgcccag atggctataa tattatttta tacacaaacc   4140

ttttttttca taaatgttat aattttgtgt ctgtctttat aaactattat aagtactatt   4200

tttgttataa ttcaaaatag atatttagta taaagttttt gctgttaaat atttgttatt   4260

tagtaaaata tgaattttgc tctattgtaa acatggttca aaatattaat atgtttttat   4320

cacagtcgtt ttaatattga aaaagcactt gtgtgttttg ttttgatatg aaactggtac   4380

cgtgtgagtg tttttgctgt cgtggtttta atctgtatat aatattccat gttgcatatt   4440

aaaaacatga atgttgtgca ttttgtgatt ttggaaatac tcaatgtggc tcttctatag   4500

gcttctagaa taaaccgtgg ggacccgcaa aaaa                               4534


<210>  690
<211>  512
<212>  PRT
<213>  Homosapiens

<400>  690

Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Thr Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Thr Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Thr Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Thr Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Gly Ser Gly Phe Gln Ser Ser Arg Arg Glu Lys Tyr 
65                  70                  75                  80  


Gly Asn Val Phe Lys Thr His Leu Leu Gly Arg Pro Leu Ile Arg Val 
                85                  90                  95      


Thr Gly Ala Glu Asn Val Arg Lys Ile Leu Met Gly Glu His His Leu 
            100                 105                 110         


Val Ser Thr Glu Trp Pro Arg Ser Thr Arg Met Leu Leu Gly Pro Asn 
        115                 120                 125             


Thr Val Ser Asn Ser Ile Gly Asp Ile His Arg Asn Lys Arg Lys Val 
    130                 135                 140                 


Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu Ser Tyr Leu Pro Lys 
145                 150                 155                 160 


Ile Gln Leu Val Ile Gln Asp Thr Leu Arg Ala Trp Ser Ser His Pro 
                165                 170                 175     


Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys Leu Thr Phe Arg Met 
            180                 185                 190         


Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro Glu Glu Asp Leu Gly 
        195                 200                 205             


His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp Asn Val Phe Ser Leu 
    210                 215                 220                 


Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly Ile Gln Ala Arg 
225                 230                 235                 240 


Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile Arg Glu Lys Leu Gln 
                245                 250                 255     


Cys Thr Gln Gly Lys Asp Tyr Leu Asp Ala Leu Asp Leu Leu Ile Glu 
            260                 265                 270         


Ser Ser Lys Glu His Gly Lys Glu Met Thr Met Gln Glu Leu Lys Asp 
        275                 280                 285             


Gly Thr Leu Glu Leu Ile Phe Ala Ala Tyr Ala Thr Thr Ala Ser Ala 
    290                 295                 300                 


Ser Thr Ser Leu Ile Met Gln Leu Leu Lys His Pro Thr Val Leu Glu 
305                 310                 315                 320 


Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile Leu His Ser Gly Gly 
                325                 330                 335     


Cys Pro Cys Glu Gly Thr Leu Arg Leu Asp Thr Leu Ser Gly Leu Arg 
            340                 345                 350         


Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg Leu Phe Thr Pro Ile 
        355                 360                 365             


Ser Gly Gly Tyr Arg Thr Val Leu Gln Thr Phe Glu Leu Asp Gly Phe 
    370                 375                 380                 


Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Thr His 
385                 390                 395                 400 


Asp Thr Ala Pro Val Phe Lys Asp Val Asn Val Phe Asp Pro Asp Arg 
                405                 410                 415     


Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly Arg Phe His Tyr Leu 
            420                 425                 430         


Pro Phe Gly Gly Gly Val Arg Thr Cys Leu Gly Lys His Leu Ala Lys 
        435                 440                 445             


Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala Ser Thr Ser Arg Phe 
    450                 455                 460                 


Glu Leu Ala Thr Arg Thr Phe Pro Arg Ile Thr Leu Val Pro Val Leu 
465                 470                 475                 480 


His Pro Val Asp Gly Leu Ser Val Lys Phe Phe Gly Leu Asp Ser Asn 
                485                 490                 495     


Gln Asn Glu Ile Leu Pro Glu Thr Glu Ala Met Leu Ser Ala Thr Val 
            500                 505                 510         


<210>  691
<211>  6020
<212>  DNA
<213>  Homosapiens

<400>  691
atggaatcca acctagcatt tcccagagaa ctacaaatcc cagcggacat tacgcagaac     60

gccgacggac gcggtgacgc aagggggcgt gtcgagcctg agggaggggt cggcctgcgg    120

gtagccagag gctggggcgg ctgtggagcc tgtggtggga gcggcattgt ggggcaggga    180

aaaggtgagc cgagccgacg gaggggacgc gctgcggggc gcccccagtc tatggagcgg    240

ggtaagatgg cggaggcgga gagcctggag acagcggcag agcacgagcg gatcctgcga    300

gagatcgaga gcactgacac ggcctgcatc gggcccacgc tcaggtctgt ttatgatggt    360

gaagaacatg gacgtttcat ggagaagctt gaaactcgta tccgtaatca cgaccgagaa    420

attgagaaaa tgtgcaactt tcattaccag ggctttgtgg actctataac tgaactgctg    480

aaagtgagag gagaagccca gaaactcaaa aatcaagtga cggatactaa tagaaaacta    540

caacatgagg gaaaggaact ggtaatagca atggaagagc tgaagcagtg tcgactacaa    600

cagagaaata tttctgccac tgttgataaa ttaatgctgt gtcttccagt cctagagatg    660

tacagcaaac tgagggacca gatgaaaact aaaaggcatt atcctgcact gaaaactctg    720

gaacatctag agcataccta cctgcctcaa gtaagccact atcgattctg caaggtgatg    780

gtggacaaca tccccaagct tcgagaagaa ataaaagatg tttctatgtc cgatctcaaa    840

gactttctgg agagcatccg caaacattca gacaaaattg gagagactgc catgaagcaa    900

gcccagcagc aaagaaacct ggataacatc gtcttgcaac aacccagaat aggtagcaag    960

aggaaatcta agaaagatgc atatataatc tttgatacag agatagaaag tactagtccg   1020

aagtctgaac aggattcagg aattctggat gttgaagacg aggaagatga tgaagaggta   1080

cctggggccc aagatttggt ggatttctct ccagtttatc gatgtctaca tatatattct   1140

gtcctgggtg cccgggaaac atttgagaat tactaccgaa aacagaggcg aaaacaggct   1200

cgtttggtac ttcaacctcc atctaacatg catgaaactt tagatggcta caggaagtat   1260

tttaatcaaa ttgtaggctt ttttgtggtt gaagatcaca ttttacatac aacccagggc   1320

ttagtaaata gagcctacat tgatgaactg tgggaaatgg cactttcaaa aaccatcgca   1380

gcactccgta cccactcgtc ttactgttct gatccaaacc ttgtgttaga tttgaagaac   1440

ctcattgtgc tttttgctga cacacttcag gtgtatggtt tccctgtaaa tcagcttttt   1500

gacatgctgt tagaaatcag agaccaatat agtgaaactc tgctaaagaa gtgggcaggt   1560

attttcagaa acatacttga ttctgacaac tacagtccta taccagtaac aagtgaagag   1620

atgtacaaaa aggtggtagg acaattccca tttcaagata tagaactgga aaagcaacca   1680

tttccaaaaa agtttccttt ctctgaattt gtgccaaaag tttacaacca aattaaagaa   1740

tttatctacg cttgtctgaa gttttcagaa gatcttcatc taagctcaac tgaagttgat   1800

gacatgattc ggaaatcaac aaacctgttg ctaaccagga ctctgagcaa ctctctgcag   1860

aatgtaatta aaaggaagaa tattgggctt actgagcttg ttcagattat tatcaataca   1920

acacatttgg agaaatcctg taagtacttg gaagaattta tcaccaacat cactaatgtg   1980

cttccagaga cagttcacac taccaagctc tatggcacca caacttttaa ggatgctaga   2040

catgcagctg aagaagagat ttataccaac ttaaaccaga agattgacca gttcctacag   2100

ctggcagact atgactggat gaccggagat ttgggcaaca aagctagtga ttacctggta   2160

gacctcattg cctttcttcg tagcaccttt gctgtattca cacaccttcc tggaaaggtg   2220

gcccagacag cgtgtatgtc agcttgcaag catttagcca catccttgat gcaacttttg   2280

ttggaagctg aagtgcggca gctcaccttg ggagcattac agcagttcaa cttggacgtc   2340

agagaatgtg aacagtttgc cagatccggc ccggtgcctg ggttccagga ggacacgctg   2400

cagttggcct tcatcgactt gagacaactt ttggatcttt tcatccagtg ggattggtca   2460

acctaccttg ctgactatgg tcagcccaac tgcaagtacc tccgggtaaa cccagtgact   2520

gctctgaccc tgcttgagaa gatgaaggat actagccgca agaacaacat gtttgcacag   2580

tttcggaaaa atgagcgaga caagcagaaa ctcattgaca ccgtggccaa gcagctccga   2640

ggactcatca gcagccacca ctcatgaagg gtgaccccgg acccacagag gcgacctgct   2700

gcagcctctg tgtcagtctg gggtccagcc ccagctgacc ctgcatttgt gcattcttct   2760

tcaaagagag catatgtatt tttttattaa cccctgtgca gtattcacat aacatttccc   2820

tatagtaaaa gaggcacaag aataagcaag tacatgagat gttgctaggc tgggactcag   2880

gggaagttat tactacacta tctgtgttat cttagagatg gtggtatcat caattccaca   2940

gtgatgaacc acctttcatc catggctcta aagcttaggt ctggggctta ggaaccataa   3000

aaagtgggta tctggcgctg ggaggtagag tgagtaagca aaaggatact aaaatatgtc   3060

ctgttcactc ttggatgccc attcaccaca tagatgaggc tgattcttct caatacaagg   3120

aaagggcatg gcaaacatta ctatttagta cactaagggc agctctggag ggtcatctcc   3180

tcagtctgct gactttcact ggcttgtgaa caagcatggc atatggcaag atgacagctt   3240

cattccaatc ccccaagaat ggcggtttct ttagcctgat ctaaccccag gcttttattg   3300

caattttttc tagggcagga tacagctaag tagacagcag taataattgg atcccatgtt   3360

taactgcata ttgccccagc tctaggagtg ttgagtctca actcgaagag tttttctgga   3420

tcttgaaagc cagttttcat ggaatcagag acccaatccc ttccctgttc atctcatttc   3480

cttcacttac agtcagagca cttggttcag gacataaatc aacagttact tccataggcc   3540

ttcacagggc gtttcagact tagcctcctc cagtaatgcc attgaaatag ttcagatttc   3600

ggaagcctaa aaatggcctt taccttaccc ttaggtgtaa cctgaggatt agttgggatt   3660

gttcctttat gttttaaaac cagctttttg gttatcatct ttaaggaaat gtcaccagct   3720

ctgcactgtg ggggcagcca tgcctggact ggatgcctct agggatggag acattgttac   3780

cataaagtcg acagagccaa ccatggcttg tggcttgttg cctctggccc aactgtcctt   3840

cactaaataa tatcctagat attattttgt tgctcaagcc caaggttccc accctctttt   3900

gagatcccca aagccatctt tggccttgtc taagaaagat tgcctataat cctgtcctcc   3960

aaactctaaa gcctggagca gcttagcgtg gaggctgcac tcattgaccc agatggactc   4020

ctgagactta acgcaagggc tttgctatga ggtcagtcgg gggaaactgt actttaagac   4080

acttcagaaa gatgctactg gctagtagca gaaagatggc tagtggcaag agtataattg   4140

tgcatcacca aacaatgaca aataagccac acaggcattt ccagcttgga ttgatgggag   4200

gagagactca tcaaacagaa ttcttcacta cctttgtcag ctactgagtt gcttctgggg   4260

agggaagtac ttccttgccc ctccccaacc cccctacctc accatatcct atcatatctt   4320

gatagtcatg gggaagagga tgtgcacaca gacatacaaa tttcctcaaa gctggagaga   4380

ccaggctaca tgtgagctca tagatgctgc tgaggctcat cctgagggct ggatggttgg   4440

ccagggtttc agaatgaggg taagggatga gcactgccac ccagaacttg ataagccaag   4500

agaaggcagg agccaaaatg gcatcgccaa gctctcatct ttgttgaaac aagtgagaaa   4560

cgattatatt aatctgaagt tctattgctt gagaagagtt caaaacactt ctctttgcta   4620

gtacccagtt tgcagcaaga tctcttcagc tttaagtgct gagagacttt gaagtggaaa   4680

tggagagatg tgtaagcatg gcacagtgtt tgtcttttta gaggatcatc attgctggtc   4740

tggtctcaaa cctctgcctt ggaagaactg tgctatacag gaaaaagtga acaaggtgga   4800

ggaatagggg ttattctgca cagaagtccc atgaaaggaa aagcttattc aagctcaaga   4860

cataaagatg gaccctttga tatatcttct ctccattctt agtctgcctt caccttatct   4920

aacaaaaaac aacatgcagc tactgagttg tatgtagaga catactcttg gtgggccagg   4980

gaaggtaaaa acagggacca gcaatgtcaa gtttttgaac tagaaaagtg ggatgttttt   5040

agttttgtct ataacctgta gctgggccaa cccttgagag gacttgtgca aagcatgtgt   5100

gcccagaccc atcagactcc tcagatatgg cctcaaatac ctagagatgt agaagtaccg   5160

tggagggcct caataagagg gcaagcacac agatggctag aagcctgtat ggcttctggt   5220

caggatgaac ccttggccaa gttcttgagg aaaccaggtc tatattcctg aagggacagt   5280

tcagtttggg actctattag gtttcagtag taatataggc tgcttgcatc attttaacat   5340

tcatagggaa aatctctttg agcaggctat aaatgaagct gttgcaggta gggaagaaca   5400

ggacctgaaa atgggaacca ggaagtgaga tcctgttggc aaagggaatg tagagcttcc   5460

agggtgcatt gcccactgtt ctcattgcat accagtcctc caagtcagtc tagccttact   5520

gtacacttga caagtgctta ctcagcaagt cccagaccca cggcctttta tctcccaaga   5580

ctggctttgg ccatgacctt cctcatcagg cctctgagca cactctctag gaactgctgc   5640

agaaattccc ctaccttagc ctcccttctc ccaggactcc tctcttgact gcaattgcct   5700

cttcttcttc ttcttcttct tcctttttgt tttttttttt tttgcctgca ttcacaatta   5760

cttttcacaa aggtgttgga aatggcattt ttattttaca cagatagttg cacatatata   5820

gagaaaatta ggaaagtcca tttttaactc taaagggaac ttttttctct aaaacttact   5880

tgtaaagcta ctgatacaga tgggccgcat ggttagggga aagctcctct gtgaaaagag   5940

catgtttatt cctcttgtac attttcctct tttaactgct attaaacaag aaagcctaca   6000

tacctgtttc aaaagccacg                                               6020


<210>  692
<211>  888
<212>  PRT
<213>  Homosapiens

<400>  692

Met Glu Ser Asn Leu Ala Phe Pro Arg Glu Leu Gln Ile Pro Ala Asp 
1               5                   10                  15      


Ile Thr Gln Asn Ala Asp Gly Arg Gly Asp Ala Arg Gly Arg Val Glu 
            20                  25                  30          


Pro Glu Gly Gly Val Gly Leu Arg Val Ala Arg Gly Trp Gly Gly Cys 
        35                  40                  45              


Gly Ala Cys Gly Gly Ser Gly Ile Val Gly Gln Gly Lys Gly Glu Pro 
    50                  55                  60                  


Ser Arg Arg Arg Gly Arg Ala Ala Gly Arg Pro Gln Ser Met Glu Arg 
65                  70                  75                  80  


Gly Lys Met Ala Glu Ala Glu Ser Leu Glu Thr Ala Ala Glu His Glu 
                85                  90                  95      


Arg Ile Leu Arg Glu Ile Glu Ser Thr Asp Thr Ala Cys Ile Gly Pro 
            100                 105                 110         


Thr Leu Arg Ser Val Tyr Asp Gly Glu Glu His Gly Arg Phe Met Glu 
        115                 120                 125             


Lys Leu Glu Thr Arg Ile Arg Asn His Asp Arg Glu Ile Glu Lys Met 
    130                 135                 140                 


Cys Asn Phe His Tyr Gln Gly Phe Val Asp Ser Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Lys Val Arg Gly Glu Ala Gln Lys Leu Lys Asn Gln Val Thr Asp Thr 
                165                 170                 175     


Asn Arg Lys Leu Gln His Glu Gly Lys Glu Leu Val Ile Ala Met Glu 
            180                 185                 190         


Glu Leu Lys Gln Cys Arg Leu Gln Gln Arg Asn Ile Ser Ala Thr Val 
        195                 200                 205             


Asp Lys Leu Met Leu Cys Leu Pro Val Leu Glu Met Tyr Ser Lys Leu 
    210                 215                 220                 


Arg Asp Gln Met Lys Thr Lys Arg His Tyr Pro Ala Leu Lys Thr Leu 
225                 230                 235                 240 


Glu His Leu Glu His Thr Tyr Leu Pro Gln Val Ser His Tyr Arg Phe 
                245                 250                 255     


Cys Lys Val Met Val Asp Asn Ile Pro Lys Leu Arg Glu Glu Ile Lys 
            260                 265                 270         


Asp Val Ser Met Ser Asp Leu Lys Asp Phe Leu Glu Ser Ile Arg Lys 
        275                 280                 285             


His Ser Asp Lys Ile Gly Glu Thr Ala Met Lys Gln Ala Gln Gln Gln 
    290                 295                 300                 


Arg Asn Leu Asp Asn Ile Val Leu Gln Gln Pro Arg Ile Gly Ser Lys 
305                 310                 315                 320 


Arg Lys Ser Lys Lys Asp Ala Tyr Ile Ile Phe Asp Thr Glu Ile Glu 
                325                 330                 335     


Ser Thr Ser Pro Lys Ser Glu Gln Asp Ser Gly Ile Leu Asp Val Glu 
            340                 345                 350         


Asp Glu Glu Asp Asp Glu Glu Val Pro Gly Ala Gln Asp Leu Val Asp 
        355                 360                 365             


Phe Ser Pro Val Tyr Arg Cys Leu His Ile Tyr Ser Val Leu Gly Ala 
    370                 375                 380                 


Arg Glu Thr Phe Glu Asn Tyr Tyr Arg Lys Gln Arg Arg Lys Gln Ala 
385                 390                 395                 400 


Arg Leu Val Leu Gln Pro Pro Ser Asn Met His Glu Thr Leu Asp Gly 
                405                 410                 415     


Tyr Arg Lys Tyr Phe Asn Gln Ile Val Gly Phe Phe Val Val Glu Asp 
            420                 425                 430         


His Ile Leu His Thr Thr Gln Gly Leu Val Asn Arg Ala Tyr Ile Asp 
        435                 440                 445             


Glu Leu Trp Glu Met Ala Leu Ser Lys Thr Ile Ala Ala Leu Arg Thr 
    450                 455                 460                 


His Ser Ser Tyr Cys Ser Asp Pro Asn Leu Val Leu Asp Leu Lys Asn 
465                 470                 475                 480 


Leu Ile Val Leu Phe Ala Asp Thr Leu Gln Val Tyr Gly Phe Pro Val 
                485                 490                 495     


Asn Gln Leu Phe Asp Met Leu Leu Glu Ile Arg Asp Gln Tyr Ser Glu 
            500                 505                 510         


Thr Leu Leu Lys Lys Trp Ala Gly Ile Phe Arg Asn Ile Leu Asp Ser 
        515                 520                 525             


Asp Asn Tyr Ser Pro Ile Pro Val Thr Ser Glu Glu Met Tyr Lys Lys 
    530                 535                 540                 


Val Val Gly Gln Phe Pro Phe Gln Asp Ile Glu Leu Glu Lys Gln Pro 
545                 550                 555                 560 


Phe Pro Lys Lys Phe Pro Phe Ser Glu Phe Val Pro Lys Val Tyr Asn 
                565                 570                 575     


Gln Ile Lys Glu Phe Ile Tyr Ala Cys Leu Lys Phe Ser Glu Asp Leu 
            580                 585                 590         


His Leu Ser Ser Thr Glu Val Asp Asp Met Ile Arg Lys Ser Thr Asn 
        595                 600                 605             


Leu Leu Leu Thr Arg Thr Leu Ser Asn Ser Leu Gln Asn Val Ile Lys 
    610                 615                 620                 


Arg Lys Asn Ile Gly Leu Thr Glu Leu Val Gln Ile Ile Ile Asn Thr 
625                 630                 635                 640 


Thr His Leu Glu Lys Ser Cys Lys Tyr Leu Glu Glu Phe Ile Thr Asn 
                645                 650                 655     


Ile Thr Asn Val Leu Pro Glu Thr Val His Thr Thr Lys Leu Tyr Gly 
            660                 665                 670         


Thr Thr Thr Phe Lys Asp Ala Arg His Ala Ala Glu Glu Glu Ile Tyr 
        675                 680                 685             


Thr Asn Leu Asn Gln Lys Ile Asp Gln Phe Leu Gln Leu Ala Asp Tyr 
    690                 695                 700                 


Asp Trp Met Thr Gly Asp Leu Gly Asn Lys Ala Ser Asp Tyr Leu Val 
705                 710                 715                 720 


Asp Leu Ile Ala Phe Leu Arg Ser Thr Phe Ala Val Phe Thr His Leu 
                725                 730                 735     


Pro Gly Lys Val Ala Gln Thr Ala Cys Met Ser Ala Cys Lys His Leu 
            740                 745                 750         


Ala Thr Ser Leu Met Gln Leu Leu Leu Glu Ala Glu Val Arg Gln Leu 
        755                 760                 765             


Thr Leu Gly Ala Leu Gln Gln Phe Asn Leu Asp Val Arg Glu Cys Glu 
    770                 775                 780                 


Gln Phe Ala Arg Ser Gly Pro Val Pro Gly Phe Gln Glu Asp Thr Leu 
785                 790                 795                 800 


Gln Leu Ala Phe Ile Asp Leu Arg Gln Leu Leu Asp Leu Phe Ile Gln 
                805                 810                 815     


Trp Asp Trp Ser Thr Tyr Leu Ala Asp Tyr Gly Gln Pro Asn Cys Lys 
            820                 825                 830         


Tyr Leu Arg Val Asn Pro Val Thr Ala Leu Thr Leu Leu Glu Lys Met 
        835                 840                 845             


Lys Asp Thr Ser Arg Lys Asn Asn Met Phe Ala Gln Phe Arg Lys Asn 
    850                 855                 860                 


Glu Arg Asp Lys Gln Lys Leu Ile Asp Thr Val Ala Lys Gln Leu Arg 
865                 870                 875                 880 


Gly Leu Ile Ser Ser His His Ser 
                885             


<210>  693
<211>  947
<212>  DNA
<213>  Homosapiens

<400>  693
ccatccctga gatcttttta taaaaaaccc agtctttgct gaccagacaa agcataccag     60

atctcaccag agagtcctag gggactacag aaggaaaaag acaagaggca gtaggatatc    120

tgtgtgtcct cccgctgacc acacttcctt tagtgacccg attgcctcct caagtcgcag    180

acactatgct gcctcccatg gccctgccca gtgtgtcctg gatgctgctt tcctgcctca    240

ttctcctgtg tcaggttcaa ggtgaagaaa cccagaagga actgccctct ccacggatca    300

gctgtcccaa aggctccaag gcctatggct ccccctgcta tgccttgttt ttgtcaccaa    360

aatcctggat ggatgcagat ctggcttgcc agaagcggcc ctctggaaaa ctggtgtctg    420

tgctcagtgg ggctgaggga tccttcgtgt cctccctggt gaggagcatt agtaacagct    480

attcatacat ctggattggg ctccatgacc ccacacaggg ctctgagcct gatggagatg    540

gatgggagtg gagtagcact gatgtgatga attactttgc atgggagaaa aatccctcca    600

ccatcttaaa ccctggccac tgtgggagcc tgtcaagaag cacaggattt ctgaagtgga    660

aagattataa ctgtgatgca aagttaccct atgtctgcaa gttcaaggac tagggcaggt    720

gggaagtcag cagcctgagc ttggcgtgca gctcatcatg gacatgagac cagtgtgaag    780

actcaccctg gaagagaata ttctccccaa actgccctac ctgactacct tgtcatgatc    840

ctccttcttt ttcctttttc ttcaccttca tttcaggctt ttctctgtct tccatgtctt    900

gagatctcag agaataataa taaaaatgtt actttatacg taaaaaa                  947


<210>  694
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  694

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Ile Leu Leu Cys Gln Val Gln Gly Glu Glu Thr Gln Lys Glu 
            20                  25                  30          


Leu Pro Ser Pro Arg Ile Ser Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Met Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Lys Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Arg Ser Ile Ser 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Ile Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Ser Glu Pro Asp Gly Asp Gly Trp Glu Trp Ser Ser Thr Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Lys Asn Pro Ser Thr Ile Leu Asn Pro Gly 
    130                 135                 140                 


His Cys Gly Ser Leu Ser Arg Ser Thr Gly Phe Leu Lys Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asp Ala Lys Leu Pro Tyr Val Cys Lys Phe Lys Asp 
                165                 170                 175 


<210>  695
<211>  847
<212>  DNA
<213>  Homosapiens

<400>  695
ccatccctga gatcttttta taaaaaaccc agtctttgct gaccagacaa agcataccag     60

atctcaccag agagtcgcag acactatgct gcctcccatg gccctgccca gtgtgtcctg    120

gatgctgctt tcctgcctca ttctcctgtg tcaggttcaa ggtgaagaaa cccagaagga    180

actgccctct ccacggatca gctgtcccaa aggctccaag gcctatggct ccccctgcta    240

tgccttgttt ttgtcaccaa aatcctggat ggatgcagat ctggcttgcc agaagcggcc    300

ctctggaaaa ctggtgtctg tgctcagtgg ggctgaggga tccttcgtgt cctccctggt    360

gaggagcatt agtaacagct attcatacat ctggattggg ctccatgacc ccacacaggg    420

ctctgagcct gatggagatg gatgggagtg gagtagcact gatgtgatga attactttgc    480

atgggagaaa aatccctcca ccatcttaaa ccctggccac tgtgggagcc tgtcaagaag    540

cacaggattt ctgaagtgga aagattataa ctgtgatgca aagttaccct atgtctgcaa    600

gttcaaggac tagggcaggt gggaagtcag cagcctgagc ttggcgtgca gctcatcatg    660

gacatgagac cagtgtgaag actcaccctg gaagagaata ttctccccaa actgccctac    720

ctgactacct tgtcatgatc ctccttcttt ttcctttttc ttcaccttca tttcaggctt    780

ttctctgtct tccatgtctt gagatctcag agaataataa taaaaatgtt actttatact    840

taaaaaa                                                              847


<210>  696
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  696

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Ile Leu Leu Cys Gln Val Gln Gly Glu Glu Thr Gln Lys Glu 
            20                  25                  30          


Leu Pro Ser Pro Arg Ile Ser Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Met Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Lys Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Arg Ser Ile Ser 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Ile Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Ser Glu Pro Asp Gly Asp Gly Trp Glu Trp Ser Ser Thr Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Lys Asn Pro Ser Thr Ile Leu Asn Pro Gly 
    130                 135                 140                 


His Cys Gly Ser Leu Ser Arg Ser Thr Gly Phe Leu Lys Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asp Ala Lys Leu Pro Tyr Val Cys Lys Phe Lys Asp 
                165                 170                 175 


<210>  697
<211>  773
<212>  DNA
<213>  Homosapiens

<400>  697
aagccacctc aagtggacaa ggcacttacc aacagagatt gctgatttgc tccttaagca     60

agagattcac tgccgctaag catggctcag accaactcgt tcttcatgct gatctcctcc    120

ctgatgttcc tgtctctgag ccaaggccag gagtcccaga cagagctgcc taatccccga    180

atcagctgcc cagaaggcac caatgcctat cgctcctact gctactactt taatgaagac    240

cctgagacct gggttgatgc agatctctat tgccagaaca tgaattcagg caacctggtg    300

tctgtgctca cccaggcgga gggtgccttc gtggcctcac tgattaagga gagtagcact    360

gatgacagca atgtctggat tggcctccat gacccaaaaa agaaccgccg ctggcactgg    420

agtagtgggt ccctggtctc ctacaagtcc tgggacactg gatccccgag cagtgctaat    480

gctggctact gtgcaagcct gacttcatgc tcaggattca agaaatggaa ggatgaatct    540

tgtgagaaga agttctcctt tgtttgcaag ttcaaaaact agaggaagct gaaaaatgga    600

tgtctagaac tggtcctgca attactatga agtcaaaaat taaactagac tatgtctcca    660

actcagttca gaccatctcc tccctaatga gtttgcatcg ctgatcttca gtaccttcac    720

ctgtctcagt ctctagagcc ctgaaaaata aaaacaaact tatttttatc cag           773


<210>  698
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  698

Met Ala Gln Thr Asn Ser Phe Phe Met Leu Ile Ser Ser Leu Met Phe 
1               5                   10                  15      


Leu Ser Leu Ser Gln Gly Gln Glu Ser Gln Thr Glu Leu Pro Asn Pro 
            20                  25                  30          


Arg Ile Ser Cys Pro Glu Gly Thr Asn Ala Tyr Arg Ser Tyr Cys Tyr 
        35                  40                  45              


Tyr Phe Asn Glu Asp Pro Glu Thr Trp Val Asp Ala Asp Leu Tyr Cys 
    50                  55                  60                  


Gln Asn Met Asn Ser Gly Asn Leu Val Ser Val Leu Thr Gln Ala Glu 
65                  70                  75                  80  


Gly Ala Phe Val Ala Ser Leu Ile Lys Glu Ser Ser Thr Asp Asp Ser 
                85                  90                  95      


Asn Val Trp Ile Gly Leu His Asp Pro Lys Lys Asn Arg Arg Trp His 
            100                 105                 110         


Trp Ser Ser Gly Ser Leu Val Ser Tyr Lys Ser Trp Asp Thr Gly Ser 
        115                 120                 125             


Pro Ser Ser Ala Asn Ala Gly Tyr Cys Ala Ser Leu Thr Ser Cys Ser 
    130                 135                 140                 


Gly Phe Lys Lys Trp Lys Asp Glu Ser Cys Glu Lys Lys Phe Ser Phe 
145                 150                 155                 160 


Val Cys Lys Phe Lys Asn 
                165     


<210>  699
<211>  808
<212>  DNA
<213>  Homosapiens

<400>  699
gatataaagc tcctacagct acctggcctg agaagccaac tcagactcag ccaacagaga     60

ttgttgattt gcctcttaag caagagattc attgcagctc agcatggctc agaccagctc    120

atacttcatg ctgatctcct gcctgatgtt tctgtctcag agccaaggcc aagaggccca    180

gacagagttg ccccaggccc ggatcagctg cccagaaggc accaatgcct atcgctccta    240

ctgctactac tttaatgaag accgtgagac ctgggttgat gcagatctct attgccagaa    300

catgaattcg ggcaacctgg tgtctgtgct cacccaggcc gagggtgcct ttgtggcctc    360

actgattaag gagagtggca ctgatgactt caatgtctgg attggcctcc atgaccccaa    420

aaagaaccgc cgctggcact ggagcagtgg gtccctggtc tcctacaagt cctggggcat    480

tggagcccca agcagtgtta atcctggcta ctgtgtgagc ctgacctcaa gcacaggatt    540

ccagaaatgg aaggatgtgc cttgtgaaga caagttctcc tttgtctgca agttcaaaaa    600

ctagaggcaa ctggaaaata catgtctaga actgatccag caattacaac ggagtcaaaa    660

attaaaccgg accatctctc caactcaact caacctggac actctcttct ctgctgagtt    720

tgccttgtta atcttcaata gttttaccta ccccagtctt tggaacccta aataataaaa    780

ataaacatgt ttccactatt gtgctgtc                                       808


<210>  700
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  700

Met Ala Gln Thr Ser Ser Tyr Phe Met Leu Ile Ser Cys Leu Met Phe 
1               5                   10                  15      


Leu Ser Gln Ser Gln Gly Gln Glu Ala Gln Thr Glu Leu Pro Gln Ala 
            20                  25                  30          


Arg Ile Ser Cys Pro Glu Gly Thr Asn Ala Tyr Arg Ser Tyr Cys Tyr 
        35                  40                  45              


Tyr Phe Asn Glu Asp Arg Glu Thr Trp Val Asp Ala Asp Leu Tyr Cys 
    50                  55                  60                  


Gln Asn Met Asn Ser Gly Asn Leu Val Ser Val Leu Thr Gln Ala Glu 
65                  70                  75                  80  


Gly Ala Phe Val Ala Ser Leu Ile Lys Glu Ser Gly Thr Asp Asp Phe 
                85                  90                  95      


Asn Val Trp Ile Gly Leu His Asp Pro Lys Lys Asn Arg Arg Trp His 
            100                 105                 110         


Trp Ser Ser Gly Ser Leu Val Ser Tyr Lys Ser Trp Gly Ile Gly Ala 
        115                 120                 125             


Pro Ser Ser Val Asn Pro Gly Tyr Cys Val Ser Leu Thr Ser Ser Thr 
    130                 135                 140                 


Gly Phe Gln Lys Trp Lys Asp Val Pro Cys Glu Asp Lys Phe Ser Phe 
145                 150                 155                 160 


Val Cys Lys Phe Lys Asn 
                165     


<210>  701
<211>  807
<212>  DNA
<213>  Homosapiens

<400>  701
aaaccatacc atatcccacc agagagtgac tcctgattgc ctcctcaagt cgcagacact     60

atgctgcctc ccatggccct gcccagtgta tcttggatgc tgctttcctg cctcatgctg    120

ctgtctcagg ttcaaggtga agaaccccag agggaactgc cctctgcacg gatccgctgt    180

cccaaaggct ccaaggccta tggctcccac tgctatgcct tgtttttgtc accaaaatcc    240

tggacagatg cagatctggc ctgccagaag cggccctctg gaaacctggt gtctgtgctc    300

agtggggctg agggatcctt cgtgtcctcc ctggtgaaga gcattggtaa cagctactca    360

tacgtctgga ttgggctcca tgaccccaca cagggcaccg agcccaatgg agaaggttgg    420

gagtggagta gcagtgatgt gatgaattac tttgcatggg agagaaatcc ctccaccatc    480

tcaagccccg gccactgtgc gagcctgtcg agaagcacag catttctgag gtggaaagat    540

tataactgta atgtgaggtt accctatgtc tgcaagttca ctgactagtg caggagggaa    600

gtcagcagcc tgtgtttggt gtgcaactca tcatgggcat gagaccagtg tgaggactca    660

ccctggaaga gaatattcgc ttaattcccc caacctgacc acctcattct tatctttctt    720

ctgtttcttc ctccccgctg tcatttcagt ctcttcattt tgtcatacgg cctaaggctt    780

taaagagcaa taaaattttt agtctgc                                        807


<210>  702
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  702

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  703
<211>  784
<212>  DNA
<213>  Homosapiens

<400>  703
aaaccatacc atatcccacc agagagtcgc agacactatg ctgcctccca tggccctgcc     60

cagtgtatct tggatgctgc tttcctgcct catgctgctg tctcaggttc aaggtgaaga    120

accccagagg gaactgccct ctgcacggat ccgctgtccc aaaggctcca aggcctatgg    180

ctcccactgc tatgccttgt ttttgtcacc aaaatcctgg acagatgcag atctggcctg    240

ccagaagcgg ccctctggaa acctggtgtc tgtgctcagt ggggctgagg gatccttcgt    300

gtcctccctg gtgaagagca ttggtaacag ctactcatac gtctggattg ggctccatga    360

ccccacacag ggcaccgagc ccaatggaga aggttgggag tggagtagca gtgatgtgat    420

gaattacttt gcatgggaga gaaatccctc caccatctca agccccggcc actgtgcgag    480

cctgtcgaga agcacagcat ttctgaggtg gaaagattat aactgtaatg tgaggttacc    540

ctatgtctgc aagttcactg actagtgcag gagggaagtc agcagcctgt gtttggtgtg    600

caactcatca tgggcatgag accagtgtga ggactcaccc tggaagagaa tattcgctta    660

attcccccaa cctgaccacc tcattcttat ctttcttctg tttcttcctc cccgctgtca    720

tttcagtctc ttcattttgt catacggcct aaggctttaa agagcaataa aatttttagt    780

ctgc                                                                 784


<210>  704
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  704

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  705
<211>  1002
<212>  DNA
<213>  Homosapiens

<400>  705
gggagggtcc cttcctcagg gagcacagga actctgagac tcagcaaggg tgtcctggga     60

gggctcgggg atgggagagt acacagattc acaactcatt cagaactgta gaagatgatg    120

gatgtgacca agatcacttt agtcctaggg gactagagaa ggaaaatgac atgaggcagt    180

ggggtatctg tgtgttctcc cactgaccac gctttcttta gtgactcctg attgcctcct    240

caagtcgcag acactatgct gcctcccatg gccctgccca gtgtatcttg gatgctgctt    300

tcctgcctca tgctgctgtc tcaggttcaa ggtgaagaac cccagaggga actgccctct    360

gcacggatcc gctgtcccaa aggctccaag gcctatggct cccactgcta tgccttgttt    420

ttgtcaccaa aatcctggac agatgcagat ctggcctgcc agaagcggcc ctctggaaac    480

ctggtgtctg tgctcagtgg ggctgaggga tccttcgtgt cctccctggt gaagagcatt    540

ggtaacagct actcatacgt ctggattggg ctccatgacc ccacacaggg caccgagccc    600

aatggagaag gttgggagtg gagtagcagt gatgtgatga attactttgc atgggagaga    660

aatccctcca ccatctcaag ccccggccac tgtgcgagcc tgtcgagaag cacagcattt    720

ctgaggtgga aagattataa ctgtaatgtg aggttaccct atgtctgcaa gttcactgac    780

tagtgcagga gggaagtcag cagcctgtgt ttggtgtgca actcatcatg ggcatgagac    840

cagtgtgagg actcaccctg gaagagaata ttcgcttaat tcccccaacc tgaccacctc    900

attcttatct ttcttctgtt tcttcctccc cgctgtcatt tcagtctctt cattttgtca    960

tacggcctaa ggctttaaag agcaataaaa tttttagtct gc                      1002


<210>  706
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  706

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  707
<211>  742
<212>  DNA
<213>  Homosapiens

<400>  707
atgcagccag tgagcggggc ccagggcgac acccagcctc tggctgctgt gactggaaat     60

caaatctcat caaggcgttt acctgctgtg gcagaggctg tgatgagggg ctcccagcat    120

gccctgagca acatgggcac tgggctagac agcccagacc tcgcggaaac aaagcgggaa    180

ggggccgctc ctggggagtt tttcccagct tccctgggcc ggccccctgg cctgaccctg    240

agtcccgggc gtaacggcgt tgttgaacca ccacaacccc aggcggcgcc ttcctcttgg    300

cccaggggct ctcttgggga cagtgtgcag tactccccaa gggggctttg ctgtgcaaaa    360

gcagcccctg ccgatgctgc ggctcccgtg gatggagcac tgccgtggga acagagttgg    420

aactcatcca aaagaataaa agacaactgt gttggaagat tgccaaggtt tgtagctgtg    480

ccaccgcaga cttcagagat gaacactgcc ttggagacga ggaggattca agttgcagaa    540

gcatttaggt gctgcgtgaa ccccagcagg gccattccag atgctccaca ggacagcgct    600

gaacgcaccg cagtgagcct gggaggccct gggctactgc tgcctcccct tctctgggct    660

gaacatcaag gtagtgcttc tgtgttcttc tcccaacttg tgcaagaaag gacattaaag    720

ttatttttat gaaattgcct aa                                             742


<210>  708
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  708

Met Gln Pro Val Ser Gly Ala Gln Gly Asp Thr Gln Pro Leu Ala Ala 
1               5                   10                  15      


Val Thr Gly Asn Gln Ile Ser Ser Arg Arg Leu Pro Ala Val Ala Glu 
            20                  25                  30          


Ala Val Met Arg Gly Ser Gln His Ala Leu Ser Asn Met Gly Thr Gly 
        35                  40                  45              


Leu Asp Ser Pro Asp Leu Ala Glu Thr Lys Arg Glu Gly Ala Ala Pro 
    50                  55                  60                  


Gly Glu Phe Phe Pro Ala Ser Leu Gly Arg Pro Pro Gly Leu Thr Leu 
65                  70                  75                  80  


Ser Pro Gly Arg Asn Gly Val Val Glu Pro Pro Gln Pro Gln Ala Ala 
                85                  90                  95      


Pro Ser Ser Trp Pro Arg Gly Ser Leu Gly Asp Ser Val Gln Tyr Ser 
            100                 105                 110         


Pro Arg Gly Leu Cys Cys Ala Lys Ala Ala Pro Ala Asp Ala Ala Ala 
        115                 120                 125             


Pro Val Asp Gly Ala Leu Pro Trp Glu Gln Ser Trp Asn Ser Ser Lys 
    130                 135                 140                 


Arg Ile Lys Asp Asn Cys Val Gly Arg Leu Pro Arg Phe Val Ala Val 
145                 150                 155                 160 


Pro Pro Gln Thr Ser Glu Met Asn Thr Ala Leu Glu Thr Arg Arg Ile 
                165                 170                 175     


Gln Val Ala Glu Ala Phe Arg Cys Cys Val Asn Pro Ser Arg Ala Ile 
            180                 185                 190         


Pro Asp Ala Pro Gln Asp Ser Ala Glu Arg Thr Ala Val Ser Leu Gly 
        195                 200                 205             


Gly Pro Gly Leu Leu Leu Pro Pro Leu Leu Trp Ala Glu His Gln Gly 
    210                 215                 220                 


Ser Ala Ser Val Phe Phe Ser Gln Leu Val Gln Glu Arg Thr Leu Lys 
225                 230                 235                 240 


Leu Phe Leu 
            


<210>  709
<211>  2009
<212>  DNA
<213>  Homosapiens

<400>  709
gaattctgat gtgcttcagt gcacagaaca gtaacagatg agctgctttt ggggagagct     60

tgagtactca gtcggagcat catcatgggg tctagtgcca cagagattga agaattggaa    120

aacaccactt ttaagtatct tacaggagaa cagactgaaa aaatgtggca gcgcctgaaa    180

ggaatactaa gatgcttggt gaagcagctg gaaagaggtg atgttaacgt cgtcgactta    240

aagaagaata ttgaatatgc ggcatctgtg ctggaagcag tttatatcga tgaaacaaga    300

agacttctgg atactgaaga tgagctcagt gacattcaga ctgactcagt cccatctgaa    360

gtccgggact ggttggcttc tacctttaca cggaaaatgg ggatgacaaa aaagaaacct    420

gaggaaaaac caaaatttcg gagcattgtg catgctgttc aagctggaat ttttgtggaa    480

agaatgtacc gaaaaacata tcatatggtt ggtttggcat atccagcagc tgtcatcgta    540

acattaaagg atgttgataa atggtctttc gatgtatttg ccctaaatga agcaagtgga    600

gagcatagtc tgaagtttat gatttatgaa ctgtttacca gatatgatct tatcaaccgt    660

ttcaagattc ctgtttcttg cctaatcacc tttgcagaag ctttagaagt tggttacagc    720

aagtacaaaa atccatatca caatttgatt catgcagctg atgtcactca aactgtgcat    780

tacataatgc ttcatacagg tatcatgcac tggctcactg aactggaaat tttagcaatg    840

gtctttgctg ctgccattca tgattatgag catacaggga caacaaacaa ctttcacatt    900

cagacaaggt cagatgttgc cattttgtat aatgatcgct ctgtccttga gaatcaccac    960

gtgagtgcag cttatcgact tatgcaagaa gaagaaatga atatcttgat aaatttatcc   1020

aaagatgact ggagggatct tcggaaccta gtgattgaaa tggttttatc tacagacatg   1080

tcaggtcact tccagcaaat taaaaatata agaaacagtt tgcagcagcc tgaagggatt   1140

gacagagcca aaaccatgtc cctgattctc cacgcagcag acatcagcca cccagccaaa   1200

tcctggaagc tgcattatcg gtggaccatg gccctaatgg aggagttttt cctgcaggga   1260

gataaagaag ctgaattagg gcttccattt tccccacttt gtgatcggaa gtcaaccatg   1320

gtggcccagt cacaaatagg tttcatcgat ttcatagtag agccaacatt ttctcttctg   1380

acagactcaa cagagaaaat tgttattcct cttatagagg aagcctcaaa agccgaaact   1440

tcttcctatg tggcaagcag ctcaaccacc attgtggggt tacacattgc tgatgcacta   1500

agacgatcaa atacaaaagg ctccatgagt gatgggtcct attccccaga ctactccctt   1560

gcagcagtgg acctgaagag tttcaagaac aacctggtgg acatcattca gcagaacaaa   1620

gagaggtgga aagagttagc tgcacaagaa gcaagaacca gttcacagaa gtgtgagttt   1680

attcatcagt aaacaccttt aagtaaaacc tcgtgcatgg tggcagctct aatttgacca   1740

aaagacttgg agattttgat tatgcttgct ggaaatctac cctgtcctgt gtgagacagg   1800

aaatctattt ttgcagattg ctcaataagc atcatgagcc acataaataa cagctgtaaa   1860

ctccttaatt caccgggctc aactgctacc gaacagattc atctagtggc tacatcagca   1920

ccttgtgctt tcagatatct gtttcaatgg cattttgtgg catttgtctt taccgagtgc   1980

caataaattt tctttgagca gctaaaaaa                                     2009


<210>  710
<211>  535
<212>  PRT
<213>  Homosapiens

<400>  710

Met Gly Ser Ser Ala Thr Glu Ile Glu Glu Leu Glu Asn Thr Thr Phe 
1               5                   10                  15      


Lys Tyr Leu Thr Gly Glu Gln Thr Glu Lys Met Trp Gln Arg Leu Lys 
            20                  25                  30          


Gly Ile Leu Arg Cys Leu Val Lys Gln Leu Glu Arg Gly Asp Val Asn 
        35                  40                  45              


Val Val Asp Leu Lys Lys Asn Ile Glu Tyr Ala Ala Ser Val Leu Glu 
    50                  55                  60                  


Ala Val Tyr Ile Asp Glu Thr Arg Arg Leu Leu Asp Thr Glu Asp Glu 
65                  70                  75                  80  


Leu Ser Asp Ile Gln Thr Asp Ser Val Pro Ser Glu Val Arg Asp Trp 
                85                  90                  95      


Leu Ala Ser Thr Phe Thr Arg Lys Met Gly Met Thr Lys Lys Lys Pro 
            100                 105                 110         


Glu Glu Lys Pro Lys Phe Arg Ser Ile Val His Ala Val Gln Ala Gly 
        115                 120                 125             


Ile Phe Val Glu Arg Met Tyr Arg Lys Thr Tyr His Met Val Gly Leu 
    130                 135                 140                 


Ala Tyr Pro Ala Ala Val Ile Val Thr Leu Lys Asp Val Asp Lys Trp 
145                 150                 155                 160 


Ser Phe Asp Val Phe Ala Leu Asn Glu Ala Ser Gly Glu His Ser Leu 
                165                 170                 175     


Lys Phe Met Ile Tyr Glu Leu Phe Thr Arg Tyr Asp Leu Ile Asn Arg 
            180                 185                 190         


Phe Lys Ile Pro Val Ser Cys Leu Ile Thr Phe Ala Glu Ala Leu Glu 
        195                 200                 205             


Val Gly Tyr Ser Lys Tyr Lys Asn Pro Tyr His Asn Leu Ile His Ala 
    210                 215                 220                 


Ala Asp Val Thr Gln Thr Val His Tyr Ile Met Leu His Thr Gly Ile 
225                 230                 235                 240 


Met His Trp Leu Thr Glu Leu Glu Ile Leu Ala Met Val Phe Ala Ala 
                245                 250                 255     


Ala Ile His Asp Tyr Glu His Thr Gly Thr Thr Asn Asn Phe His Ile 
            260                 265                 270         


Gln Thr Arg Ser Asp Val Ala Ile Leu Tyr Asn Asp Arg Ser Val Leu 
        275                 280                 285             


Glu Asn His His Val Ser Ala Ala Tyr Arg Leu Met Gln Glu Glu Glu 
    290                 295                 300                 


Met Asn Ile Leu Ile Asn Leu Ser Lys Asp Asp Trp Arg Asp Leu Arg 
305                 310                 315                 320 


Asn Leu Val Ile Glu Met Val Leu Ser Thr Asp Met Ser Gly His Phe 
                325                 330                 335     


Gln Gln Ile Lys Asn Ile Arg Asn Ser Leu Gln Gln Pro Glu Gly Ile 
            340                 345                 350         


Asp Arg Ala Lys Thr Met Ser Leu Ile Leu His Ala Ala Asp Ile Ser 
        355                 360                 365             


His Pro Ala Lys Ser Trp Lys Leu His Tyr Arg Trp Thr Met Ala Leu 
    370                 375                 380                 


Met Glu Glu Phe Phe Leu Gln Gly Asp Lys Glu Ala Glu Leu Gly Leu 
385                 390                 395                 400 


Pro Phe Ser Pro Leu Cys Asp Arg Lys Ser Thr Met Val Ala Gln Ser 
                405                 410                 415     


Gln Ile Gly Phe Ile Asp Phe Ile Val Glu Pro Thr Phe Ser Leu Leu 
            420                 425                 430         


Thr Asp Ser Thr Glu Lys Ile Val Ile Pro Leu Ile Glu Glu Ala Ser 
        435                 440                 445             


Lys Ala Glu Thr Ser Ser Tyr Val Ala Ser Ser Ser Thr Thr Ile Val 
    450                 455                 460                 


Gly Leu His Ile Ala Asp Ala Leu Arg Arg Ser Asn Thr Lys Gly Ser 
465                 470                 475                 480 


Met Ser Asp Gly Ser Tyr Ser Pro Asp Tyr Ser Leu Ala Ala Val Asp 
                485                 490                 495     


Leu Lys Ser Phe Lys Asn Asn Leu Val Asp Ile Ile Gln Gln Asn Lys 
            500                 505                 510         


Glu Arg Trp Lys Glu Leu Ala Ala Gln Glu Ala Arg Thr Ser Ser Gln 
        515                 520                 525             


Lys Cys Glu Phe Ile His Gln 
    530                 535 


<210>  711
<211>  2414
<212>  DNA
<213>  Homosapiens

<400>  711
gtcagagtct tccctcagct ttgtacatca gcactgtttt gatagataag agaggctact     60

gtataagtgt gtaagatttg taatggactg aggaatgctt gttctagctg ctgaaactga    120

ctgtaactgt attgtcttag gagcatcatc atggggtcta gtgccacaga gattgaagaa    180

ttggaaaaca ccacttttaa gtatcttaca ggagaacaga ctgaaaaaat gtggcagcgc    240

ctgaaaggaa tactaagatg cttggtgaag cagctggaaa gaggtgatgt taacgtcgtc    300

gacttaaaga agaatattga atatgcggca tctgtgctgg aagcagttta tatcgatgaa    360

acaagaagac ttctggatac tgaagatgag ctcagtgaca ttcagactga ctcagtccca    420

tctgaagtcc gggactggtt ggcttctacc tttacacgga aaatggggat gacaaaaaag    480

aaacctgagg aaaaaccaaa atttcggagc attgtgcatg ctgttcaagc tggaattttt    540

gtggaaagaa tgtaccgaaa aacatatcat atggttggtt tggcatatcc agcagctgtc    600

atcgtaacat taaaggatgt tgataaatgg tctttcgatg tatttgccct aaatgaagca    660

agtggagagc atagtctgaa gtttatgatt tatgaactgt ttaccagata tgatcttatc    720

aaccgtttca agattcctgt ttcttgccta atcacctttg cagaagcttt agaagttggt    780

tacagcaagt acaaaaatcc atatcacaat ttgattcatg cagctgatgt cactcaaact    840

gtgcattaca taatgcttca tacaggtatc atgcactggc tcactgaact ggaaatttta    900

gcaatggtct ttgctgctgc cattcatgat tatgagcata cagggacaac aaacaacttt    960

cacattcaga caaggtcaga tgttgccatt ttgtataatg atcgctctgt ccttgagaat   1020

caccacgtga gtgcagctta tcgacttatg caagaagaag aaatgaatat cttgataaat   1080

ttatccaaag atgactggag ggatcttcgg aacctagtga ttgaaatggt tttatctaca   1140

gacatgtcag gtcacttcca gcaaattaaa aatataagaa acagtttgca gcagcctgaa   1200

gggattgaca gagccaaaac catgtccctg attctccacg cagcagacat cagccaccca   1260

gccaaatcct ggaagctgca ttatcggtgg accatggccc taatggagga gtttttcctg   1320

cagggagata aagaagctga attagggctt ccattttccc cactttgtga tcggaagtca   1380

accatggtgg cccagtcaca aataggtttc atcgatttca tagtagagcc aacattttct   1440

cttctgacag actcaacaga gaaaattgtt attcctctta tagaggaagc ctcaaaagcc   1500

gaaacttctt cctatgtggc aagcagctca accaccattg tggggttaca cattgctgat   1560

gcactaagac gatcaaatac aaaaggctcc atgagtgatg ggtcctattc cccagactac   1620

tcccttgcag cagtggacct gaagagtttc aagaacaacc tggtggacat cattcagcag   1680

aacaaagaga ggtggaaaga gttagctgca caaggtgaat ctgatcttca taagaactca   1740

gaagacttag taaatgctga agaaaaacat gatgagacac attcataggc ccgaaacacc   1800

ttaaagactt ctgtcatttt aaacatgaga ggacaatgaa atcagcatga aaacatccta   1860

aattctcaac tttccacaaa gctatggctc ttctttcaac atagaattgg attgggccat   1920

tttaattgac tcctatacaa ggaattaaga agaacataaa ttttgagcta gtaactctgg   1980

ccaaataaat acactcaagt ttttatcaga gtttttggcc agtgcttctg ccattttttt   2040

ccctccacaa tttggccttc ttcaatcaag ccagataaat ttttgagaca aaagtcagac   2100

agtttttaat ttttcttgct ttgaaccctg tcataatgac tgtgcaatac atgtgcagaa   2160

gatgaggtat tttaaaattt acttccttgc actgtcttac acagagtgct ataactataa   2220

atttttcaag gtcttaaata aaaggaagca aaaacaaaat tattgaaaaa ttttttttgt   2280

tgtgctgggg aatatactat ttagattgtc cttcttattt taaatgcatg ggaacagaat   2340

gacagggggg atgctgagga gctggttgaa gcatcagagc aatgctacag tccaacaatg   2400

gagcattaga tccc                                                     2414


<210>  712
<211>  545
<212>  PRT
<213>  Homosapiens

<400>  712

Met Gly Ser Ser Ala Thr Glu Ile Glu Glu Leu Glu Asn Thr Thr Phe 
1               5                   10                  15      


Lys Tyr Leu Thr Gly Glu Gln Thr Glu Lys Met Trp Gln Arg Leu Lys 
            20                  25                  30          


Gly Ile Leu Arg Cys Leu Val Lys Gln Leu Glu Arg Gly Asp Val Asn 
        35                  40                  45              


Val Val Asp Leu Lys Lys Asn Ile Glu Tyr Ala Ala Ser Val Leu Glu 
    50                  55                  60                  


Ala Val Tyr Ile Asp Glu Thr Arg Arg Leu Leu Asp Thr Glu Asp Glu 
65                  70                  75                  80  


Leu Ser Asp Ile Gln Thr Asp Ser Val Pro Ser Glu Val Arg Asp Trp 
                85                  90                  95      


Leu Ala Ser Thr Phe Thr Arg Lys Met Gly Met Thr Lys Lys Lys Pro 
            100                 105                 110         


Glu Glu Lys Pro Lys Phe Arg Ser Ile Val His Ala Val Gln Ala Gly 
        115                 120                 125             


Ile Phe Val Glu Arg Met Tyr Arg Lys Thr Tyr His Met Val Gly Leu 
    130                 135                 140                 


Ala Tyr Pro Ala Ala Val Ile Val Thr Leu Lys Asp Val Asp Lys Trp 
145                 150                 155                 160 


Ser Phe Asp Val Phe Ala Leu Asn Glu Ala Ser Gly Glu His Ser Leu 
                165                 170                 175     


Lys Phe Met Ile Tyr Glu Leu Phe Thr Arg Tyr Asp Leu Ile Asn Arg 
            180                 185                 190         


Phe Lys Ile Pro Val Ser Cys Leu Ile Thr Phe Ala Glu Ala Leu Glu 
        195                 200                 205             


Val Gly Tyr Ser Lys Tyr Lys Asn Pro Tyr His Asn Leu Ile His Ala 
    210                 215                 220                 


Ala Asp Val Thr Gln Thr Val His Tyr Ile Met Leu His Thr Gly Ile 
225                 230                 235                 240 


Met His Trp Leu Thr Glu Leu Glu Ile Leu Ala Met Val Phe Ala Ala 
                245                 250                 255     


Ala Ile His Asp Tyr Glu His Thr Gly Thr Thr Asn Asn Phe His Ile 
            260                 265                 270         


Gln Thr Arg Ser Asp Val Ala Ile Leu Tyr Asn Asp Arg Ser Val Leu 
        275                 280                 285             


Glu Asn His His Val Ser Ala Ala Tyr Arg Leu Met Gln Glu Glu Glu 
    290                 295                 300                 


Met Asn Ile Leu Ile Asn Leu Ser Lys Asp Asp Trp Arg Asp Leu Arg 
305                 310                 315                 320 


Asn Leu Val Ile Glu Met Val Leu Ser Thr Asp Met Ser Gly His Phe 
                325                 330                 335     


Gln Gln Ile Lys Asn Ile Arg Asn Ser Leu Gln Gln Pro Glu Gly Ile 
            340                 345                 350         


Asp Arg Ala Lys Thr Met Ser Leu Ile Leu His Ala Ala Asp Ile Ser 
        355                 360                 365             


His Pro Ala Lys Ser Trp Lys Leu His Tyr Arg Trp Thr Met Ala Leu 
    370                 375                 380                 


Met Glu Glu Phe Phe Leu Gln Gly Asp Lys Glu Ala Glu Leu Gly Leu 
385                 390                 395                 400 


Pro Phe Ser Pro Leu Cys Asp Arg Lys Ser Thr Met Val Ala Gln Ser 
                405                 410                 415     


Gln Ile Gly Phe Ile Asp Phe Ile Val Glu Pro Thr Phe Ser Leu Leu 
            420                 425                 430         


Thr Asp Ser Thr Glu Lys Ile Val Ile Pro Leu Ile Glu Glu Ala Ser 
        435                 440                 445             


Lys Ala Glu Thr Ser Ser Tyr Val Ala Ser Ser Ser Thr Thr Ile Val 
    450                 455                 460                 


Gly Leu His Ile Ala Asp Ala Leu Arg Arg Ser Asn Thr Lys Gly Ser 
465                 470                 475                 480 


Met Ser Asp Gly Ser Tyr Ser Pro Asp Tyr Ser Leu Ala Ala Val Asp 
                485                 490                 495     


Leu Lys Ser Phe Lys Asn Asn Leu Val Asp Ile Ile Gln Gln Asn Lys 
            500                 505                 510         


Glu Arg Trp Lys Glu Leu Ala Ala Gln Gly Glu Ser Asp Leu His Lys 
        515                 520                 525             


Asn Ser Glu Asp Leu Val Asn Ala Glu Glu Lys His Asp Glu Thr His 
    530                 535                 540                 


Ser 
545 


<210>  713
<211>  4193
<212>  DNA
<213>  Homosapiens

<400>  713
agaccggcgc gtgaggaacc taccggtacc ggccgcgcgc tggtagtcgc cggtgtggct     60

gcacctcacc aatcccgtgc gccgcggctg ggccgtcgga gagtgcgtgt gcttctctcc    120

tgcacgcggt gcttgggctc ggccaggcgg ggtccgccgc cagggtttga ggatggggga    180

gtagctacag gaagcgaccc cgcgatggca aggtatattt ttgtggaatg aaaaggaagt    240

attagaaatg agctgaagac cattcacaga ttaatatttt tggggacaga tttgtgatgc    300

ttgattcacc cttgaagtaa tgtagacaga agttctcaaa tttgcatatt acatcaactg    360

gaaccagcag tgaatcttaa tgttcactta aatcagaact tgcataagaa agagaatggg    420

agtctggtta aataaagatg actatatcag agacttgaaa aggatcattc tctgttttct    480

gatagtgtat atggccattt tagtgggcac agatcaggat ttttacagtt tacttggagt    540

gtccaaaact gcaagcagta gagaaataag acaagctttc aagaaattgg cattgaagtt    600

acatcctgat aaaaacccga ataacccaaa tgcacatggc gattttttaa aaataaatag    660

agcatatgaa gtactcaaag atgaagatct acggaaaaag tatgacaaat atggagaaaa    720

gggacttgag gataatcaag gtggccagta tgaaagctgg aactattatc gttatgattt    780

tggtatttat gatgatgatc ctgaaatcat aacattggaa agaagagaat ttgatgctgc    840

tgttaattct ggagaactgt ggtttgtaaa tttttactcc ccaggctgtt cacactgcca    900

tgatttagct cccacatgga gagactttgc taaagaagtg gatgggttac ttcgaattgg    960

agctgttaac tgtggtgatg atagaatgct ttgccgaatg aaaggagtca acagctatcc   1020

cagcctcttc atttttcggt ctggaatggc cccagtgaaa tatcatggag acagatcaaa   1080

ggagagttta gtgagttttg caatgcagca tgttagaagt acagtgacag aactttggac   1140

aggaaatttt gtcaactcca tacaaactgc ctttgctgct ggtattggct ggctgatcac   1200

tttttgttca aaaggaggag attgtttgac ttcacagaca cgactcaggc ttagtggcat   1260

gttggatggt cttgttaatg taggatggat ggactgtgcc acccaggata acctttgtaa   1320

aagcttagat attacaacaa gtactactgc ttattttcct cctggagcca ctttaaataa   1380

caaagagaaa aacagtattt tgtttctcaa ctcattggat gctaaagaaa tatatttgga   1440

agtaatacat aatcttccag attttgaact actttcggca aacacactag aggatcgttt   1500

ggctcatcat cggtggctgt tattttttca ttttggaaaa aatgaaaatt caaatgatcc   1560

tgagctgaaa aaactaaaaa ctctacttaa aaatgatcat attcaagttg gcaggtttga   1620

ctgttcctct gcaccagaca tctgtagtaa tctgtatgtt tttcagccgt ctctagcagt   1680

atttaaagga caaggaacca aagaatatga aattcatcat ggaaagaaga ttctatatga   1740

tatacttgcc tttgccaaag aaagtgtgaa ttctcatgtt accacgcttg gacctcaaaa   1800

ttttcctgcc aatgacaaag aaccatggct tgttgatttc tttgccccct ggtgtccacc   1860

atgtcgagct ttactaccag agttacgaag agcatcaaat cttctttatg gtcagcttaa   1920

gtttggtaca ctagattgta cagttcatga gggactctgt aacatgtata acattcaggc   1980

ttatccaacg acagtggtat tcaaccagtc caacattcat gagtatgaag gacatcactc   2040

tgctgaacaa atcttggagt tcatagagga tcttatgaat ccttcagtgg tctcccttac   2100

acccaccacc ttcaacgaac tagttacaca aagaaaacac aacgaagtct ggatggttga   2160

tttctattct ccgtggtgtc atccttgcca agtcttaatg ccagaatgga aaagaatggc   2220

ccggacatta actggactga tcaacgtggg cagtatagat tgccaacagt atcattcttt   2280

ttgtgcccag gaaaacgttc aaagataccc tgagataaga ttttttcccc caaaatcaaa   2340

taaagcttat cattatcaca gttacaatgg ttggaatagg gatgcttatt ccctgagaat   2400

ctggggtcta ggatttttac ctcaagtatc cacagatcta acacctcaga ctttcagtga   2460

aaaagttcta caagggaaaa atcattgggt gattgatttc tatgctcctt ggtgtggacc   2520

ttgccagaat tttgctccag aatttgagct cttggctagg atgattaaag gaaaagtgaa   2580

agctggaaaa gtagactgtc aggcttatgc tcagacatgc cagaaagctg ggatcagggc   2640

ctatccaact gttaaatttt atttctacga aagagcaaag agaaattttc aagaagagca   2700

gataaatacc agagatgcaa aagcaatcgc tgccttaata agtgaaaaat tggaaactct   2760

ccgaaatcaa ggcaagagga ataaggatga actttgataa tgttgaagat gaagaaaaag   2820

tttaaaagaa attctgacag atgacatcag aagacaccta tttagaatgt tacatttatg   2880

atgggaatga atgaacatta tcttagactt gcagttgtac tgccagaatt atctacagca   2940

ctggtgtaaa agaagggtct gcaaactttt tctgtaaagg gccggtttat aaatatttta   3000

gactttgcag gctataatat atggttcaca catgagaaca agaatagagt catcatgtat   3060

tctttgttat ttgcttttaa caacctttaa aaaatattaa aacgattctt agctcagagc   3120

catacaaaag taggctggat tcagtccatg gaccatagat tgctgtcccc ctcgacggac   3180

ttataatgtt tcaggtggct ggcttgaaca tgagtctgct gtgctatcta cataaatgtc   3240

taagttgtat aaagtccact ttcccttcac gttttttggc tgacctgaaa agaggtaact   3300

tagtttttgg tcacttgttc tcctaaaaat gctatcccta accatatatt tatatttcgt   3360

tttaaaaaca cccatgatgt ggcacagtaa acaaaccctg ttatgctgta ttattatgag   3420

gagattcttc attgttttct ttccttctca aaggttgaaa aaatgctttt aatttttcac   3480

agccgagaaa cagtgcagca gtatatgtgc acacagtaag tacacaaatt tgagcaacag   3540

taagtgcaca aattctgtag tttgccgtat catccaggaa aacctgaggg aaaaaaatta   3600

tagcaattaa ctgggcattg tagagtatcc taaatatgtt atcaagtatt tagagttcta   3660

tattttaaag atatatgtgt tcatgtattt tctgaaattg ctttcataga aattttccca   3720

ctgatagttg atttttgagg catctaatat ttacatattt gccttctgaa ctttgttttg   3780

acctgtatcc tttatttaca ttgggttttt ctttcgtagt tttggttttt cactcctgtc   3840

cagtctattt attattcaaa taggaaaaat tactttacag gttgttttac tgtagcttat   3900

aatgatactg tagttattcc agttactagt ttactgtcag agggctgcct ttttcagata   3960

aatattgaca taataactga agttattttt ataagaaaat caagtatata aatctaggaa   4020

agggatcttc tagtttctgt gttgtttaga ctcaaagaat cacaaatttg tcagtaacat   4080

gtagttgttt agttataatt cagagtgtac agaatggtaa aaattccaat cagtcaaaag   4140

aggtcaatga attaaaaggc ttgcaacttt ttcaaaaacc tgttagaata tgc          4193


<210>  714
<211>  793
<212>  PRT
<213>  Homosapiens

<400>  714

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp 
                165                 170                 175     


Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu 
            180                 185                 190         


Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser Leu Phe Ile Phe Arg 
        195                 200                 205             


Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser 
    210                 215                 220                 


Leu Val Ser Phe Ala Met Gln His Val Arg Ser Thr Val Thr Glu Leu 
225                 230                 235                 240 


Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Phe Ala Ala Gly 
                245                 250                 255     


Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr 
            260                 265                 270         


Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Asp Gly Leu Val Asn 
        275                 280                 285             


Val Gly Trp Met Asp Cys Ala Thr Gln Asp Asn Leu Cys Lys Ser Leu 
    290                 295                 300                 


Asp Ile Thr Thr Ser Thr Thr Ala Tyr Phe Pro Pro Gly Ala Thr Leu 
305                 310                 315                 320 


Asn Asn Lys Glu Lys Asn Ser Ile Leu Phe Leu Asn Ser Leu Asp Ala 
                325                 330                 335     


Lys Glu Ile Tyr Leu Glu Val Ile His Asn Leu Pro Asp Phe Glu Leu 
            340                 345                 350         


Leu Ser Ala Asn Thr Leu Glu Asp Arg Leu Ala His His Arg Trp Leu 
        355                 360                 365             


Leu Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Pro Glu Leu 
    370                 375                 380                 


Lys Lys Leu Lys Thr Leu Leu Lys Asn Asp His Ile Gln Val Gly Arg 
385                 390                 395                 400 


Phe Asp Cys Ser Ser Ala Pro Asp Ile Cys Ser Asn Leu Tyr Val Phe 
                405                 410                 415     


Gln Pro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu Tyr Glu 
            420                 425                 430         


Ile His His Gly Lys Lys Ile Leu Tyr Asp Ile Leu Ala Phe Ala Lys 
        435                 440                 445             


Glu Ser Val Asn Ser His Val Thr Thr Leu Gly Pro Gln Asn Phe Pro 
    450                 455                 460                 


Ala Asn Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro Trp Cys 
465                 470                 475                 480 


Pro Pro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser Asn Leu 
                485                 490                 495     


Leu Tyr Gly Gln Leu Lys Phe Gly Thr Leu Asp Cys Thr Val His Glu 
            500                 505                 510         


Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val 
        515                 520                 525             


Phe Asn Gln Ser Asn Ile His Glu Tyr Glu Gly His His Ser Ala Glu 
    530                 535                 540                 


Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro Ser Val Val Ser 
545                 550                 555                 560 


Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn 
                565                 570                 575     


Glu Val Trp Met Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln 
            580                 585                 590         


Val Leu Met Pro Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu 
        595                 600                 605             


Ile Asn Val Gly Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala 
    610                 615                 620                 


Gln Glu Asn Val Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro Pro Lys 
625                 630                 635                 640 


Ser Asn Lys Ala Tyr His Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp 
                645                 650                 655     


Ala Tyr Ser Leu Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln Val Ser 
            660                 665                 670         


Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys 
        675                 680                 685             


Asn His Trp Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln 
    690                 695                 700                 


Asn Phe Ala Pro Glu Phe Glu Leu Leu Ala Arg Met Ile Lys Gly Lys 
705                 710                 715                 720 


Val Lys Ala Gly Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr Cys Gln 
                725                 730                 735     


Lys Ala Gly Ile Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe Tyr Glu 
            740                 745                 750         


Arg Ala Lys Arg Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg Asp Ala 
        755                 760                 765             


Lys Ala Ile Ala Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu Arg Asn 
    770                 775                 780                 


Gln Gly Lys Arg Asn Lys Asp Glu Leu 
785                 790             


<210>  715
<211>  2032
<212>  DNA
<213>  Homosapiens

<400>  715
cgcggggcgc ggagtcggcg gggcctcgcg ggacgcgggc agtgcggaga ccgcggcgct     60

gaggacgcgg gagccgggag cgcacgcgcg gggtggagtt cagcctactc tttcttagat    120

gtgaaaggaa aggaagatca tttcatgcct tgttgataaa ggttcagact tctgctgatt    180

cataaccatt tggctctgag ctatgacaag agaggaaaca aaaagttaaa cttacaagcc    240

tgccataagt gagaagcaaa cttccttgat aacatgcttt tgcgaagtgc aggaaaatta    300

aatgtgggca ccaagaaaga ggatggtgag agtacagccc ccaccccccg tccaaaggtc    360

ttgcgttgta aatgccacca ccattgtcca gaagactcag tcaacaatat ttgcagcaca    420

gacggatatt gtttcacgat gatagaagag gatgactctg ggttgcctgt ggtcacttct    480

ggttgcctag gactagaagg ctcagatttt cagtgtcggg acactcccat tcctcatcaa    540

agaagatcaa ttgaatgctg cacagaaagg aacgaatgta ataaagacct acaccctaca    600

ctgcctccat tgaaaaacag agattttgtt gatggaccta tacaccacag ggctttactt    660

atatctgtga ctgtctgtag tttgctcttg gtccttatca tattattttg ttacttccgg    720

tataaaagac aagaaaccag acctcgatac agcattgggt tagaacagga tgaaacttac    780

attcctcctg gagaatccct gagagactta attgagcagt ctcagagctc aggaagtgga    840

tcaggcctcc ctctgctggt ccaaaggact atagctaagc agattcagat ggtgaaacag    900

attggaaaag gtcgctatgg ggaagtttgg atgggaaagt ggcgtggcga aaaggtagct    960

gtgaaagtgt tcttcaccac agaggaagcc agctggttca gagagacaga aatatatcag   1020

acagtgttga tgaggcatga aaacattttg ggtttcattg ctgcagatat caaagggaca   1080

gggtcctgga cccagttgta cctaatcaca gactatcatg aaaatggttc cctttatgat   1140

tatctgaagt ccaccaccct agacgctaaa tcaatgctga agttagccta ctcttctgtc   1200

agtggcttat gtcatttaca cacagaaatc tttagtactc aaggcaaacc agcaattgcc   1260

catcgagatc tgaaaagtaa aaacattctg gtgaagaaaa atggaacttg ctgtattgct   1320

gacctgggcc tggctgttaa atttattagt gatacaaatg aagttgacat accacctaac   1380

actcgagttg gcaccaaacg ctatatgcct ccagaagtgt tggacgagag cttgaacaga   1440

aatcacttcc agtcttacat catggctgac atgtatagtt ttggcctcat cctttgggag   1500

gttgctagga gatgtgtatc aggaggtata gtggaagaat accagcttcc ttatcatgac   1560

ctagtgccca gtgacccctc ttatgaggac atgagggaga ttgtgtgcat caagaagtta   1620

cgcccctcat tcccaaaccg gtggagcagt gatgagtgtc taaggcagat gggaaaactc   1680

atgacagaat gctgggctca caatcctgca tcaaggctga cagccctgcg ggttaagaaa   1740

acacttgcca aaatgtcaga gtcccaggac attaaactct gataggagag gaaaagtaag   1800

catctctgca gaaagccaac aggtactctt ctgtttgtgg gcagagcaaa agacatcaaa   1860

taagcatcca cagtacaagc cttgaacatc gtcctgcttc ccagtgggtt cagacctcac   1920

ctttcaggga gcgacctggg caaagacaga gaagctccca gaaggagaga ttgatccgtg   1980

tctgtttgta ggcggagaaa ccgttgggta acttgttcaa gatatgatgc at           2032


<210>  716
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  716

Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Thr Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ala Pro Thr Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Thr Asp Gly Tyr Cys Phe Thr Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Thr Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Thr Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Thr Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Thr Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu 
        115                 120                 125             


Leu Ile Ser Val Thr Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu 
    130                 135                 140                 


Phe Cys Tyr Phe Arg Tyr Lys Arg Gln Glu Thr Arg Pro Arg Tyr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Gln Asp Glu Thr Tyr Ile Pro Pro Gly Glu Ser Leu 
                165                 170                 175     


Arg Asp Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu 
            180                 185                 190         


Pro Leu Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Lys 
        195                 200                 205             


Gln Ile Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg 
    210                 215                 220                 


Gly Glu Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser 
225                 230                 235                 240 


Trp Phe Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu 
                245                 250                 255     


Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp 
            260                 265                 270         


Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr 
        275                 280                 285             


Asp Tyr Leu Lys Ser Thr Thr Leu Asp Ala Lys Ser Met Leu Lys Leu 
    290                 295                 300                 


Ala Tyr Ser Ser Val Ser Gly Leu Cys His Leu His Thr Glu Ile Phe 
305                 310                 315                 320 


Ser Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys 
                325                 330                 335     


Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly 
            340                 345                 350         


Leu Ala Val Lys Phe Ile Ser Asp Thr Asn Glu Val Asp Ile Pro Pro 
        355                 360                 365             


Asn Thr Arg Val Gly Thr Lys Arg Tyr Met Pro Pro Glu Val Leu Asp 
    370                 375                 380                 


Glu Ser Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met 
385                 390                 395                 400 


Tyr Ser Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser 
                405                 410                 415     


Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro 
            420                 425                 430         


Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys 
        435                 440                 445             


Leu Arg Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg 
    450                 455                 460                 


Gln Met Gly Lys Leu Met Thr Glu Cys Trp Ala His Asn Pro Ala Ser 
465                 470                 475                 480 


Arg Leu Thr Ala Leu Arg Val Lys Lys Thr Leu Ala Lys Met Ser Glu 
                485                 490                 495     


Ser Gln Asp Ile Lys Leu 
            500         


<210>  717
<211>  3646
<212>  DNA
<213>  Homosapiens

<400>  717
ctgcctttgg agaaagtgga gtgtggcgct tggttgtcgt tatttcttcg gactgcttcg     60

cggtgcacgg attcagcttc tgcccagtgg ggctttcagc tgtttgcgcg tctctctgtc    120

cccctcccct ccccccggca cacctctgtc tacgatgagg aaaggtctgc gggcgacagc    180

ggcccgctgc ggactgggac tgggatactt gctgcaaatg ctcgtgctac ctgccctggc    240

cctgctcagc gccagcggca ctggctccgc cgcccaagat gatgactttt ttcatgaact    300

cccagaaact tttccttctg atccacctga gcctctgcca catttcctta ttgagcctga    360

agaagcttat attgtgaaga ataagcctgt gaacctgtac tgtaaagcaa gccctgccac    420

ccagatctat ttcaagtgta atagtgaatg ggttcatcag aaggaccaca tagtagatga    480

aagagtagat gaaacttccg gtctcattgt ccgggaagtg agcattgaga tttcgcgcca    540

gcaagtggaa gaactctttg gacctgaaga ttactggtgc cagtgtgtgg cctggagctc    600

cgcgggtacc acaaagagcc ggaaggcgta tgtgcgcatt gcatatctac ggaagacatt    660

tgagcaggaa cccctaggaa aggaagtgtc tttggaacag gaagtcttac tccagtgtcg    720

accacctgaa gggatcccag tggctgaggt ggaatggttg aaaaatgaag acataattga    780

tcccgttgaa gatcggaatt tttatattac tattgatcac aacctcatca taaagcaggc    840

ccgactctct gatactgcaa attacacctg tgttgccaaa aacattgttg ccaagaggaa    900

aagtacaact gccactgtca tagtctatgt caacggtggc tggtccacct ggacggagtg    960

gtctgtgtgt aacagccgct gtggacgagg gtatcagaaa cgtacaagga cttgtaccaa   1020

cccggcacca ctcaatgggg gtgccttctg tgaagggcag agtgtgcaga aaatagcctg   1080

tactacgtta tgcccagtgg atggcaggtg gacgccatgg agcaagtggt ctacttgtgg   1140

aactgagtgc acccactggc gcaggaggga gtgcacggcg ccagccccca agaatggagg   1200

caaggactgc gacggcctcg tcttgcaatc caagaactgc actgatgggc tttgcatgca   1260

gactgctcct gattcagatg atgttgctct ctatgttggg attgtgatag cagtgatcgt   1320

ttgcctggcg atctctgtag ttgtggcctt gtttgtgtat cggaagaatc atcgtgactt   1380

tgagtcagat attattgact cttcggcact caatgggggc tttcagcctg tgaacatcaa   1440

ggcagcaaga caagatctgc tggctgtacc cccagacctc acgtcagctg cagccatgta   1500

cagaggacct gtctatgccc tgcatgacgt ctcagacaaa atcccaatga ccaactctcc   1560

aattctggat ccactgccca acctgaaaat caaagtgtac aacacctcag gtgctgtcac   1620

cccccaagat gacctctctg agtttacgtc caagctgtcc cctcagatga cccagtcgtt   1680

gttggagaat gaagccctca gcctgaagaa ccagagtcta gcaaggcaga ctgatccatc   1740

ctgtaccgca tttggcagct tcaactcgct gggaggtcac cttattgttc ccaattcagg   1800

agtcagcttg ctgattcccg ctggggccat tccccaaggg agagtctacg aaatgtatgt   1860

gactgtacac aggaaagaaa ctatgaggcc acccatggat gactctcaga cacttttgac   1920

ccctgtggtg agctgtgggc ccccaggagc tctgctcacc cgccccgtcg tcctcactat   1980

gcatcactgc gcagacccca ataccgagga ctggaaaata ctgctcaaga accaggcagc   2040

acagggacag tgggaggatg tggtggtggt cggggaggaa aacttcacca ccccctgcta   2100

cattaagctg gatgcagagg cctgccacat cctcacagag aacctcagca cctacgccct   2160

ggtaggacat tccaccacca aagcggctgc aaagcgcctc aagctggcca tctttgggcc   2220

cctgtgctgc tcctcgctgg agtacagcat ccgagtctac tgtctggatg acacccagga   2280

tgccctgaag gaaattttac atcttgagag acagacggga ggacagctcc tagaagaacc   2340

taaggctctt cattttaaag gcagcaccca caacctgcgc ctgtcaattc acgatatcgc   2400

ccattccctc tggaagagca aattgctggc taaatatcag gaaattccat tttaccatgt   2460

ttggagtgga tctcaaagaa acctgcactg caccttcact ctggaaagat ttagcctgaa   2520

cacagtggag ctggtttgca aactctgtgt gcggcaggtg gaaggagaag ggcagatctt   2580

ccagctcaac tgcaccgtgt cagaggaacc tactggcatc gatttgccgc tgctggatcc   2640

tgcgaacacc atcaccacgg tcacggggcc cagtgctttc agcatccctc tccctatccg   2700

gcagaagctc tgtagcagcc tggatgcccc ccagacgaga ggccatgact ggaggatgct   2760

ggcccataag ctgaacctgg acaggtactt gaattacttt gccaccaaat ccagcccaac   2820

tggcgtaatc ctggatcttt gggaagcaca gaacttccca gatggaaacc tgagcatgct   2880

ggcagctgtc ttggaagaaa tgggaagaca tgaaacggtg gtgtccttag cagcagaagg   2940

gcagtattaa ccaccatgct ggaaggggaa atgaaggaca aaaatgcaca gggagtctgt   3000

ggccgtccag gtgaatcaca gctgaggagg aaatccagat gagaccaatg cacttcacag   3060

gcaagaatgc agcaggagcc agaaggaaaa cagatacaac tgcccatgta catgcccact   3120

ttactcggag atcatcacgg gagttaagaa aaattgtgta aatttgtacc ttgaatttag   3180

ctatcaacct aattttcctc ttagttgggc tgtatgctgt gtggtacagg atcttacagt   3240

ttcctaggaa acgcttttta ttgctatcca gatatatgga taaactttct taacaaaccc   3300

aatttctaca aatgttgttt acatcaaatt ggacagggat gcagacactg tccatggctc   3360

gttctatttt tgttcaaatc atttgaagtt gaagctgtgg acggtttgtt gtgtctattt   3420

cagattagta atttacagag aaatcacaga cttttgctac aaatcgtgtg catcaagtgt   3480

ctcagataat cctcccatca gtgttctgtt tctagaactt gtagaaccag tgttactgtt   3540

tgtatcaggg aagtggagaa tctaagtgta aaaaagaaat aactaagact cctattcctt   3600

ggagggaccc ttctggtgcc ctttgggaat aaagctgtag cactgc                  3646


<210>  718
<211>  931
<212>  PRT
<213>  Homosapiens

<400>  718

Met Arg Lys Gly Leu Arg Ala Thr Ala Ala Arg Cys Gly Leu Gly Leu 
1               5                   10                  15      


Gly Tyr Leu Leu Gln Met Leu Val Leu Pro Ala Leu Ala Leu Leu Ser 
            20                  25                  30          


Ala Ser Gly Thr Gly Ser Ala Ala Gln Asp Asp Asp Phe Phe His Glu 
        35                  40                  45              


Leu Pro Glu Thr Phe Pro Ser Asp Pro Pro Glu Pro Leu Pro His Phe 
    50                  55                  60                  


Leu Ile Glu Pro Glu Glu Ala Tyr Ile Val Lys Asn Lys Pro Val Asn 
65                  70                  75                  80  


Leu Tyr Cys Lys Ala Ser Pro Ala Thr Gln Ile Tyr Phe Lys Cys Asn 
                85                  90                  95      


Ser Glu Trp Val His Gln Lys Asp His Ile Val Asp Glu Arg Val Asp 
            100                 105                 110         


Glu Thr Ser Gly Leu Ile Val Arg Glu Val Ser Ile Glu Ile Ser Arg 
        115                 120                 125             


Gln Gln Val Glu Glu Leu Phe Gly Pro Glu Asp Tyr Trp Cys Gln Cys 
    130                 135                 140                 


Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Lys Ala Tyr Val 
145                 150                 155                 160 


Arg Ile Ala Tyr Leu Arg Lys Thr Phe Glu Gln Glu Pro Leu Gly Lys 
                165                 170                 175     


Glu Val Ser Leu Glu Gln Glu Val Leu Leu Gln Cys Arg Pro Pro Glu 
            180                 185                 190         


Gly Ile Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp Ile Ile 
        195                 200                 205             


Asp Pro Val Glu Asp Arg Asn Phe Tyr Ile Thr Ile Asp His Asn Leu 
    210                 215                 220                 


Ile Ile Lys Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr Cys Val 
225                 230                 235                 240 


Ala Lys Asn Ile Val Ala Lys Arg Lys Ser Thr Thr Ala Thr Val Ile 
                245                 250                 255     


Val Tyr Val Asn Gly Gly Trp Ser Thr Trp Thr Glu Trp Ser Val Cys 
            260                 265                 270         


Asn Ser Arg Cys Gly Arg Gly Tyr Gln Lys Arg Thr Arg Thr Cys Thr 
        275                 280                 285             


Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln Ser Val 
    290                 295                 300                 


Gln Lys Ile Ala Cys Thr Thr Leu Cys Pro Val Asp Gly Arg Trp Thr 
305                 310                 315                 320 


Pro Trp Ser Lys Trp Ser Thr Cys Gly Thr Glu Cys Thr His Trp Arg 
                325                 330                 335     


Arg Arg Glu Cys Thr Ala Pro Ala Pro Lys Asn Gly Gly Lys Asp Cys 
            340                 345                 350         


Asp Gly Leu Val Leu Gln Ser Lys Asn Cys Thr Asp Gly Leu Cys Met 
        355                 360                 365             


Gln Thr Ala Pro Asp Ser Asp Asp Val Ala Leu Tyr Val Gly Ile Val 
    370                 375                 380                 


Ile Ala Val Ile Val Cys Leu Ala Ile Ser Val Val Val Ala Leu Phe 
385                 390                 395                 400 


Val Tyr Arg Lys Asn His Arg Asp Phe Glu Ser Asp Ile Ile Asp Ser 
                405                 410                 415     


Ser Ala Leu Asn Gly Gly Phe Gln Pro Val Asn Ile Lys Ala Ala Arg 
            420                 425                 430         


Gln Asp Leu Leu Ala Val Pro Pro Asp Leu Thr Ser Ala Ala Ala Met 
        435                 440                 445             


Tyr Arg Gly Pro Val Tyr Ala Leu His Asp Val Ser Asp Lys Ile Pro 
    450                 455                 460                 


Met Thr Asn Ser Pro Ile Leu Asp Pro Leu Pro Asn Leu Lys Ile Lys 
465                 470                 475                 480 


Val Tyr Asn Thr Ser Gly Ala Val Thr Pro Gln Asp Asp Leu Ser Glu 
                485                 490                 495     


Phe Thr Ser Lys Leu Ser Pro Gln Met Thr Gln Ser Leu Leu Glu Asn 
            500                 505                 510         


Glu Ala Leu Ser Leu Lys Asn Gln Ser Leu Ala Arg Gln Thr Asp Pro 
        515                 520                 525             


Ser Cys Thr Ala Phe Gly Ser Phe Asn Ser Leu Gly Gly His Leu Ile 
    530                 535                 540                 


Val Pro Asn Ser Gly Val Ser Leu Leu Ile Pro Ala Gly Ala Ile Pro 
545                 550                 555                 560 


Gln Gly Arg Val Tyr Glu Met Tyr Val Thr Val His Arg Lys Glu Thr 
                565                 570                 575     


Met Arg Pro Pro Met Asp Asp Ser Gln Thr Leu Leu Thr Pro Val Val 
            580                 585                 590         


Ser Cys Gly Pro Pro Gly Ala Leu Leu Thr Arg Pro Val Val Leu Thr 
        595                 600                 605             


Met His His Cys Ala Asp Pro Asn Thr Glu Asp Trp Lys Ile Leu Leu 
    610                 615                 620                 


Lys Asn Gln Ala Ala Gln Gly Gln Trp Glu Asp Val Val Val Val Gly 
625                 630                 635                 640 


Glu Glu Asn Phe Thr Thr Pro Cys Tyr Ile Lys Leu Asp Ala Glu Ala 
                645                 650                 655     


Cys His Ile Leu Thr Glu Asn Leu Ser Thr Tyr Ala Leu Val Gly His 
            660                 665                 670         


Ser Thr Thr Lys Ala Ala Ala Lys Arg Leu Lys Leu Ala Ile Phe Gly 
        675                 680                 685             


Pro Leu Cys Cys Ser Ser Leu Glu Tyr Ser Ile Arg Val Tyr Cys Leu 
    690                 695                 700                 


Asp Asp Thr Gln Asp Ala Leu Lys Glu Ile Leu His Leu Glu Arg Gln 
705                 710                 715                 720 


Thr Gly Gly Gln Leu Leu Glu Glu Pro Lys Ala Leu His Phe Lys Gly 
                725                 730                 735     


Ser Thr His Asn Leu Arg Leu Ser Ile His Asp Ile Ala His Ser Leu 
            740                 745                 750         


Trp Lys Ser Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His 
        755                 760                 765             


Val Trp Ser Gly Ser Gln Arg Asn Leu His Cys Thr Phe Thr Leu Glu 
    770                 775                 780                 


Arg Phe Ser Leu Asn Thr Val Glu Leu Val Cys Lys Leu Cys Val Arg 
785                 790                 795                 800 


Gln Val Glu Gly Glu Gly Gln Ile Phe Gln Leu Asn Cys Thr Val Ser 
                805                 810                 815     


Glu Glu Pro Thr Gly Ile Asp Leu Pro Leu Leu Asp Pro Ala Asn Thr 
            820                 825                 830         


Ile Thr Thr Val Thr Gly Pro Ser Ala Phe Ser Ile Pro Leu Pro Ile 
        835                 840                 845             


Arg Gln Lys Leu Cys Ser Ser Leu Asp Ala Pro Gln Thr Arg Gly His 
    850                 855                 860                 


Asp Trp Arg Met Leu Ala His Lys Leu Asn Leu Asp Arg Tyr Leu Asn 
865                 870                 875                 880 


Tyr Phe Ala Thr Lys Ser Ser Pro Thr Gly Val Ile Leu Asp Leu Trp 
                885                 890                 895     


Glu Ala Gln Asn Phe Pro Asp Gly Asn Leu Ser Met Leu Ala Ala Val 
            900                 905                 910         


Leu Glu Glu Met Gly Arg His Glu Thr Val Val Ser Leu Ala Ala Glu 
        915                 920                 925             


Gly Gln Tyr 
    930     


<210>  719
<211>  5501
<212>  DNA
<213>  Homosapiens

<400>  719
cagtcaagta gcttcccagt cccgaacgcc gcccgtcccc accccgccgt ggccactagc     60

aacgacctct gtgaagttgg agaggcggta acggaggcac tccccctgct gcaccccgcc    120

gtttctacgg ggctcagaaa ccagtttgtt tgtttcgtcg gggtagtgtc gacctgtctt    180

acgggcgtcg cccgagacag gacggagtca aacccgtggt atcaactgaa gacgagtgtc    240

aggtgtggag agtctcagtg ccccctttca gtctggactg tgagctgctg ctggttagac    300

agtcttggtt tctctttcag gatgtcattt tcaaaatgcg ggatggtacc tctgctttat    360

taagccccgt aggaagactg ccacacctag actgatgctt attagtcatc accgttattc    420

ctactaacgt cctgtgtcac tgagtttttt aaatgtctag catatctgta aagatgcctt    480

agaaaaagaa tcatggagaa gtatgttaga ctacagaaga ttggagaagg ttcatttgga    540

aaagccattc ttgttaaatc tacagaagat ggcagacagt atgttatcaa ggaaattaac    600

atctcaagaa tgtccagtaa agaaagagaa gaatcaagga gagaagttgc agtattggca    660

aacatgaagc atccaaatat tgtccagtat agagaatcat ttgaagaaaa tggctctctc    720

tacatagtaa tggattactg tgagggaggg gatctgttta agcgaataaa tgctcagaaa    780

ggcgttttgt ttcaagagga tcagattttg gactggtttg tacagatatg tttggccctg    840

aaacatgtac atgatagaaa aattcttcat cgagacatta aatctcagaa catattttta    900

actaaagatg gaacagtaca acttggagat tttggaattg ctagagttct taatagtact    960

gtagagctgg ctcgaacttg catagggacc ccatactact tgtcacctga aatctgtgaa   1020

aacaaacctt acaataataa aagtgacatt tgggctctgg ggtgtgtcct ttatgagctg   1080

tgtacactta aacatgcttt tgaagctggc agtatgaaaa acctggtact gaagataata   1140

tctggatctt ttccacctgt gtctttgcat tattcctatg atctccgcag tttggtgtct   1200

cagttattta aaagaaatcc tagggataga ccatcagtca actccatatt ggagaaaggt   1260

tttatagcca aacgcattga aaagtttctc tctcctcagc ttattgcaga agaattttgt   1320

ctaaaaacat tttcgaagtt tggatcacag cctataccag ctaaaagacc agcttcagga   1380

caaaactcga tttctgttat gcctgctcag aaaattacaa agcctgccgc taaatatgga   1440

atacctttag catataagaa atatggagat aaaaaattac acgaaaagaa accactgcaa   1500

aaacataaac aggcccatca aactccagag aagagagtga atactggaga agaaaggagg   1560

aaaatatctg aggaagcagc aagaaagaga aggctggaat ttattgaaaa agaaaagaaa   1620

caaaaggatc agattattag tttaatgaag gctgaacaaa tgaaaaggca agaaaaggaa   1680

aggttggaaa gaataaatag ggccagggaa caaggatgga gaaatgtgct aagtgctggt   1740

ggaagtggtg aagtaaaggc tccttttctg ggcagtggag ggactatagc tccatcatct   1800

ttttcttctc gaggacagta tgaacattac catgccattt ttgaccaaat gcagcaacaa   1860

agagcagaag ataatgaagc taaatggaaa agagaaatat atggtcgagg tcttccagaa   1920

agaggaattc tgcctggagt tcgtccagga tttccttatg gggctgcagg tcatcaccat   1980

tttcctgatg ctgatgatat tagaaaaact ttgaaaagat tgaaggcggt gtctaaacaa   2040

gccaatgcaa acaggcaaaa agggcagcta gctgtagaaa gagctaaaca agtagaagag   2100

ttcctgcagc gaaaacggga agctatgcag aataaagctc gagccgaagg acatatggtt   2160

tatctggcaa gactgaggca aataagacta cagaatttca atgagcgcca acagattaaa   2220

gccaaacttc gtggtgaaaa gaaagaagct aatcattctg aaggacaaga aggaagtgaa   2280

gaggctgaca tgaggcgcaa aaaaatcgaa tcactgaagg cccatgcaaa tgcacgtgct   2340

gctgtactaa aagaacaact agaacgaaag agaaaggagg cttatgagag agaaaaaaaa   2400

gtgtgggaag agcatttggt ggctaaagga gttaagagtt ctgatgtttc tccacctttg   2460

ggacagcatg aaacaggtgg ctctccatca aagcaacaga tgagatctgt tatttctgta   2520

acttcagctt tgaaagaagt tggcgtggac agtagtttaa ctgatacccg ggaaacttca   2580

gaagagatgc aaaagaccaa caatgctatt tcaagtaagc gagaaatact tcgtagatta   2640

aatgaaaatc ttaaagctca agaagatgaa aaaggaaagc agaatctctc tgatactttt   2700

gagataaatg ttcatgaaga tgccaaagag catgaaaaag aaaaatcagt ttcatctgat   2760

cgcaagaagt gggaggcagg aggtcaactt gtgattcctc tggatgagtt aacactagat   2820

acatccttct ctacaactga aagacataca gtgggagaag ttattaaatt aggtcctaat   2880

ggatctccaa gaagagcctg ggggaaaagt ccgacagatt ctgttctaaa gatacttgga   2940

gaagctgaac tacaacttca gacagaacta ttagaaaata caactattag aagtgagatt   3000

tctcccgaag gggaaaagta caaaccctta attactggag aaaaaaaagt acaatgtatt   3060

tcacatgaaa taaacccatc agctattgtt gattctcctg ttgagacaaa aagtcccgag   3120

ttcagtgagg catctccaca gatgtcattg aaactggaag gaaatttaga agaacctgat   3180

gatttggaaa cagaaattct acaagagcca agtggaacaa acaaagatga gagcttgcca   3240

tgcactatta ctgatgtgtg gattagtgag gaaaaagaaa caaaggaaac tcagtcggca   3300

gataggatca ccattcagga aaatgaagtt tctgaagatg gagtctcgag tactgtggac   3360

caacttagtg acattcatat agagcctgga accaatgatt ctcagcactc taaatgtgat   3420

gtagataagt ctgtgcaacc ggaaccattt ttccataagg tggttcattc tgaacacttg   3480

aacttagtcc ctcaagttca atcagttcag tgttcaccag aagaatcctt tgcatttcga   3540

tctcactcgc atttaccacc aaaaaataaa aacaagaatt ccttgctgat tggactttca   3600

actggtctgt ttgatgcaaa caacccaaag atgttaagga catgttcact tccagatctc   3660

tcaaagctgt tcagaaccct tatggatgtt cccaccgtag gagatgttcg tcaagacaat   3720

cttgaaatag atgaaattga agatgaaaac attaaagaag gaccttctga ttctgaagac   3780

attgtgtttg aagaaactga cacagattta caagagctgc aggcctcgat ggaacagtta   3840

cttagggaac aacctggtga agaatacagt gaagaagaag agtcagtctt gaagaacagt   3900

gatgtggagc caactgcaaa tgggacagat gtggcagatg aagatgacaa tcccagcagt   3960

gaaagtgccc tgaacgaaga atggcactca gataacagtg atggtgaaat tgctagtgaa   4020

tgtgaatgcg atagtgtctt taaccattta gaggaactga gacttcatct ggagcaggaa   4080

atgggctttg aaaaattctt tgaggtttat gagaaaataa aggctattca tgaagatgaa   4140

gatgaaaata ttgaaatttg ttcaaaaata gttcaaaata ttttgggaaa tgaacatcag   4200

catctttatg ccaagattct tcatttagtc atggcagatg gagcctacca agaagataat   4260

gatgaataat cctcaaaatg ttttttaatc ctcaactata tgaaagcatt tgaatttggc   4320

ttatcagaat aacaagcttc agtgggaaat acagcaatta tttatttaaa aaatcagatt   4380

taagatggac tttcttattg catgaaaaag atggagaaac atgccatttt tcaatgaaga   4440

ttctaatatt ttatctattt tgttcattga attccatggt taaatctcat aaaatatata   4500

ctttattaaa tcatccaacc aaagcatagg aaacattgac ccagaacctg acttaatggt   4560

tttgaagatt tactatgcaa tagggtaact ttgagtttca gcaaatgtct ttaggttgaa   4620

ggaattacct atgtcatgaa ggacctgtct gtggtttttc aatggagtct ttaagcatga   4680

tcttttttct gtctagtact tgttttcatt ctggccagca gttctacatt aaatcacctt   4740

gtcaagggct ctgtttacat ctatacattt tgaagatgaa atttttagcc ttaaagttta   4800

tattctcaag tccttttaca atcagtgtgt ctcctgaact agcacacagg ctgtagaaac   4860

agtcttagaa atcattgaaa gatttgatta tgaaagaata gcaaaattat atttcttgac   4920

atataaaaag ttggtttaat gcctttattt ctctttaagg accagaacca ggaatactat   4980

atcgaaaaat tagtctgtgg atttaacact gacttagcat atagcttaaa gttgctcttt   5040

tggtttttaa cttcctccat acataagctt caaggacaat aagatgttaa aaaggaggaa   5100

ataattattt ttattttgac actgtgacag ttttggtaac taggatccta gggagggaaa   5160

tgtttgcctg ttgaacttct ttctgttatg agaggattta gttaggtcat taagatgttg   5220

atcacacagc ttcaatcaca atatgccaag tataacctgg tttcgttaga ggtgtctaca   5280

gtccagatgt tcttcgtaat aaaagcaaag tttttgaacc tctgagtcca aagcaggctg   5340

gttggcataa tatgtaattt gaaaaataaa atcttatctt gcagcactat cagtatgttg   5400

aatttattat gtatattatt tctaatatcc gaaactaaat acttgatttt ttaatatgtg   5460

tgtttatttt atgatattgc tattaaattt ttattatcta c                       5501


<210>  720
<211>  1258
<212>  PRT
<213>  Homosapiens

<400>  720

Met Glu Lys Tyr Val Arg Leu Gln Lys Ile Gly Glu Gly Ser Phe Gly 
1               5                   10                  15      


Lys Ala Ile Leu Val Lys Ser Thr Glu Asp Gly Arg Gln Tyr Val Ile 
            20                  25                  30          


Lys Glu Ile Asn Ile Ser Arg Met Ser Ser Lys Glu Arg Glu Glu Ser 
        35                  40                  45              


Arg Arg Glu Val Ala Val Leu Ala Asn Met Lys His Pro Asn Ile Val 
    50                  55                  60                  


Gln Tyr Arg Glu Ser Phe Glu Glu Asn Gly Ser Leu Tyr Ile Val Met 
65                  70                  75                  80  


Asp Tyr Cys Glu Gly Gly Asp Leu Phe Lys Arg Ile Asn Ala Gln Lys 
                85                  90                  95      


Gly Val Leu Phe Gln Glu Asp Gln Ile Leu Asp Trp Phe Val Gln Ile 
            100                 105                 110         


Cys Leu Ala Leu Lys His Val His Asp Arg Lys Ile Leu His Arg Asp 
        115                 120                 125             


Ile Lys Ser Gln Asn Ile Phe Leu Thr Lys Asp Gly Thr Val Gln Leu 
    130                 135                 140                 


Gly Asp Phe Gly Ile Ala Arg Val Leu Asn Ser Thr Val Glu Leu Ala 
145                 150                 155                 160 


Arg Thr Cys Ile Gly Thr Pro Tyr Tyr Leu Ser Pro Glu Ile Cys Glu 
                165                 170                 175     


Asn Lys Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ala Leu Gly Cys Val 
            180                 185                 190         


Leu Tyr Glu Leu Cys Thr Leu Lys His Ala Phe Glu Ala Gly Ser Met 
        195                 200                 205             


Lys Asn Leu Val Leu Lys Ile Ile Ser Gly Ser Phe Pro Pro Val Ser 
    210                 215                 220                 


Leu His Tyr Ser Tyr Asp Leu Arg Ser Leu Val Ser Gln Leu Phe Lys 
225                 230                 235                 240 


Arg Asn Pro Arg Asp Arg Pro Ser Val Asn Ser Ile Leu Glu Lys Gly 
                245                 250                 255     


Phe Ile Ala Lys Arg Ile Glu Lys Phe Leu Ser Pro Gln Leu Ile Ala 
            260                 265                 270         


Glu Glu Phe Cys Leu Lys Thr Phe Ser Lys Phe Gly Ser Gln Pro Ile 
        275                 280                 285             


Pro Ala Lys Arg Pro Ala Ser Gly Gln Asn Ser Ile Ser Val Met Pro 
    290                 295                 300                 


Ala Gln Lys Ile Thr Lys Pro Ala Ala Lys Tyr Gly Ile Pro Leu Ala 
305                 310                 315                 320 


Tyr Lys Lys Tyr Gly Asp Lys Lys Leu His Glu Lys Lys Pro Leu Gln 
                325                 330                 335     


Lys His Lys Gln Ala His Gln Thr Pro Glu Lys Arg Val Asn Thr Gly 
            340                 345                 350         


Glu Glu Arg Arg Lys Ile Ser Glu Glu Ala Ala Arg Lys Arg Arg Leu 
        355                 360                 365             


Glu Phe Ile Glu Lys Glu Lys Lys Gln Lys Asp Gln Ile Ile Ser Leu 
    370                 375                 380                 


Met Lys Ala Glu Gln Met Lys Arg Gln Glu Lys Glu Arg Leu Glu Arg 
385                 390                 395                 400 


Ile Asn Arg Ala Arg Glu Gln Gly Trp Arg Asn Val Leu Ser Ala Gly 
                405                 410                 415     


Gly Ser Gly Glu Val Lys Ala Pro Phe Leu Gly Ser Gly Gly Thr Ile 
            420                 425                 430         


Ala Pro Ser Ser Phe Ser Ser Arg Gly Gln Tyr Glu His Tyr His Ala 
        435                 440                 445             


Ile Phe Asp Gln Met Gln Gln Gln Arg Ala Glu Asp Asn Glu Ala Lys 
    450                 455                 460                 


Trp Lys Arg Glu Ile Tyr Gly Arg Gly Leu Pro Glu Arg Gly Ile Leu 
465                 470                 475                 480 


Pro Gly Val Arg Pro Gly Phe Pro Tyr Gly Ala Ala Gly His His His 
                485                 490                 495     


Phe Pro Asp Ala Asp Asp Ile Arg Lys Thr Leu Lys Arg Leu Lys Ala 
            500                 505                 510         


Val Ser Lys Gln Ala Asn Ala Asn Arg Gln Lys Gly Gln Leu Ala Val 
        515                 520                 525             


Glu Arg Ala Lys Gln Val Glu Glu Phe Leu Gln Arg Lys Arg Glu Ala 
    530                 535                 540                 


Met Gln Asn Lys Ala Arg Ala Glu Gly His Met Val Tyr Leu Ala Arg 
545                 550                 555                 560 


Leu Arg Gln Ile Arg Leu Gln Asn Phe Asn Glu Arg Gln Gln Ile Lys 
                565                 570                 575     


Ala Lys Leu Arg Gly Glu Lys Lys Glu Ala Asn His Ser Glu Gly Gln 
            580                 585                 590         


Glu Gly Ser Glu Glu Ala Asp Met Arg Arg Lys Lys Ile Glu Ser Leu 
        595                 600                 605             


Lys Ala His Ala Asn Ala Arg Ala Ala Val Leu Lys Glu Gln Leu Glu 
    610                 615                 620                 


Arg Lys Arg Lys Glu Ala Tyr Glu Arg Glu Lys Lys Val Trp Glu Glu 
625                 630                 635                 640 


His Leu Val Ala Lys Gly Val Lys Ser Ser Asp Val Ser Pro Pro Leu 
                645                 650                 655     


Gly Gln His Glu Thr Gly Gly Ser Pro Ser Lys Gln Gln Met Arg Ser 
            660                 665                 670         


Val Ile Ser Val Thr Ser Ala Leu Lys Glu Val Gly Val Asp Ser Ser 
        675                 680                 685             


Leu Thr Asp Thr Arg Glu Thr Ser Glu Glu Met Gln Lys Thr Asn Asn 
    690                 695                 700                 


Ala Ile Ser Ser Lys Arg Glu Ile Leu Arg Arg Leu Asn Glu Asn Leu 
705                 710                 715                 720 


Lys Ala Gln Glu Asp Glu Lys Gly Lys Gln Asn Leu Ser Asp Thr Phe 
                725                 730                 735     


Glu Ile Asn Val His Glu Asp Ala Lys Glu His Glu Lys Glu Lys Ser 
            740                 745                 750         


Val Ser Ser Asp Arg Lys Lys Trp Glu Ala Gly Gly Gln Leu Val Ile 
        755                 760                 765             


Pro Leu Asp Glu Leu Thr Leu Asp Thr Ser Phe Ser Thr Thr Glu Arg 
    770                 775                 780                 


His Thr Val Gly Glu Val Ile Lys Leu Gly Pro Asn Gly Ser Pro Arg 
785                 790                 795                 800 


Arg Ala Trp Gly Lys Ser Pro Thr Asp Ser Val Leu Lys Ile Leu Gly 
                805                 810                 815     


Glu Ala Glu Leu Gln Leu Gln Thr Glu Leu Leu Glu Asn Thr Thr Ile 
            820                 825                 830         


Arg Ser Glu Ile Ser Pro Glu Gly Glu Lys Tyr Lys Pro Leu Ile Thr 
        835                 840                 845             


Gly Glu Lys Lys Val Gln Cys Ile Ser His Glu Ile Asn Pro Ser Ala 
    850                 855                 860                 


Ile Val Asp Ser Pro Val Glu Thr Lys Ser Pro Glu Phe Ser Glu Ala 
865                 870                 875                 880 


Ser Pro Gln Met Ser Leu Lys Leu Glu Gly Asn Leu Glu Glu Pro Asp 
                885                 890                 895     


Asp Leu Glu Thr Glu Ile Leu Gln Glu Pro Ser Gly Thr Asn Lys Asp 
            900                 905                 910         


Glu Ser Leu Pro Cys Thr Ile Thr Asp Val Trp Ile Ser Glu Glu Lys 
        915                 920                 925             


Glu Thr Lys Glu Thr Gln Ser Ala Asp Arg Ile Thr Ile Gln Glu Asn 
    930                 935                 940                 


Glu Val Ser Glu Asp Gly Val Ser Ser Thr Val Asp Gln Leu Ser Asp 
945                 950                 955                 960 


Ile His Ile Glu Pro Gly Thr Asn Asp Ser Gln His Ser Lys Cys Asp 
                965                 970                 975     


Val Asp Lys Ser Val Gln Pro Glu Pro Phe Phe His Lys Val Val His 
            980                 985                 990         


Ser Glu His Leu Asn Leu Val Pro  Gln Val Gln Ser Val  Gln Cys Ser 
        995                 1000                 1005             


Pro Glu  Glu Ser Phe Ala Phe  Arg Ser His Ser His  Leu Pro Pro 
    1010                 1015                 1020             


Lys Asn  Lys Asn Lys Asn Ser  Leu Leu Ile Gly Leu  Ser Thr Gly 
    1025                 1030                 1035             


Leu Phe  Asp Ala Asn Asn Pro  Lys Met Leu Arg Thr  Cys Ser Leu 
    1040                 1045                 1050             


Pro Asp  Leu Ser Lys Leu Phe  Arg Thr Leu Met Asp  Val Pro Thr 
    1055                 1060                 1065             


Val Gly  Asp Val Arg Gln Asp  Asn Leu Glu Ile Asp  Glu Ile Glu 
    1070                 1075                 1080             


Asp Glu  Asn Ile Lys Glu Gly  Pro Ser Asp Ser Glu  Asp Ile Val 
    1085                 1090                 1095             


Phe Glu  Glu Thr Asp Thr Asp  Leu Gln Glu Leu Gln  Ala Ser Met 
    1100                 1105                 1110             


Glu Gln  Leu Leu Arg Glu Gln  Pro Gly Glu Glu Tyr  Ser Glu Glu 
    1115                 1120                 1125             


Glu Glu  Ser Val Leu Lys Asn  Ser Asp Val Glu Pro  Thr Ala Asn 
    1130                 1135                 1140             


Gly Thr  Asp Val Ala Asp Glu  Asp Asp Asn Pro Ser  Ser Glu Ser 
    1145                 1150                 1155             


Ala Leu  Asn Glu Glu Trp His  Ser Asp Asn Ser Asp  Gly Glu Ile 
    1160                 1165                 1170             


Ala Ser  Glu Cys Glu Cys Asp  Ser Val Phe Asn His  Leu Glu Glu 
    1175                 1180                 1185             


Leu Arg  Leu His Leu Glu Gln  Glu Met Gly Phe Glu  Lys Phe Phe 
    1190                 1195                 1200             


Glu Val  Tyr Glu Lys Ile Lys  Ala Ile His Glu Asp  Glu Asp Glu 
    1205                 1210                 1215             


Asn Ile  Glu Ile Cys Ser Lys  Ile Val Gln Asn Ile  Leu Gly Asn 
    1220                 1225                 1230             


Glu His  Gln His Leu Tyr Ala  Lys Ile Leu His Leu  Val Met Ala 
    1235                 1240                 1245             


Asp Gly  Ala Tyr Gln Glu Asp  Asn Asp Glu 
    1250                 1255             


<210>  721
<211>  3982
<212>  DNA
<213>  Homosapiens

<400>  721
gccgcttctc ttccccttcc gtgggtcagg gccggtccgg tccggaacct gcagcccctt     60

tcccagtgtt ctagttcgcc cgtgacccgg aataatgagc aaggagggtg tggtgggttg    120

aaagccatcc tactttactc ccgagttaga gcatggattc agttttagtc ttaaggggga    180

agtgagattg gagattttta tttttaattt tgggcagaag caggttgact ctagggatct    240

ccagagcgag aggatttaac ttcatgttgc tcccgtgttt gaaggaggac aataaaagtc    300

ccaccgggca aaattttcgt aacctctgcg gtagaaaacg tcaggtatct tttaaatcgc    360

gatagttttc gctgtgtcag gctttcttcg gtggagctcc gagggtagct aggttctagg    420

tttgaaacag atgcagaatc caaaggcagc gcaaaaaaca gccaccgatt ttgctatgtc    480

tctgagctgc gagataatca gacagctaaa tggagtctga gcagctgttc catagaggct    540

actatagaaa cagctacaac agtataacaa gtgcaagtag tgatgaggaa cttttagatg    600

gagcaggtgt tattatggac tttcaaacat ctgaagatga caatttatta gatggtgaca    660

ctgcagttgg aactcattat acaatgacaa atggaggcag cattaacagt tctacacatt    720

tactggatct tttggatgaa ccaattccag gtgttggtac atatgatgat ttccatacta    780

ttgattgggt gcgagaaaaa tgtaaagaca gagaaaggca tagacggatc aacagcaaaa    840

agaaagaatc agcatgggaa atgacaaaaa gtttgtatga tgcgtggtca ggatggctag    900

tagtaacact aacaggattg gcatcagggg cactggccgg attaatagac attgctgccg    960

attggatgac tgacctaaag gagggcattt gccttagtgc gttgtggtac aaccacgaac   1020

agtgctgttg gggatctaat gaaacaacat ttgaagagag ggataaatgt ccacagtgga   1080

aaacatgggc agaattaatc ataggtcaag cagagggtcc tggttcttat atcatgaact   1140

acataatgta catcttctgg gccttgagtt ttgcctttct tgcagtttcc ctggtaaagg   1200

tatttgctcc atatgcctgt ggctctggaa ttccagagat taaaactatt ttaagtggat   1260

tcatcatcag aggttacttg ggaaaatgga ctttaatgat taaaaccatc acattagtcc   1320

tggctgtggc atcaggtttg agtttaggaa aagaaggtcc cctggtacat gttgcctgtt   1380

gctgcggaaa tatcttttcc tacctctttc caaagtatag cacaaacgaa gctaaaaaaa   1440

gggaggtgct atcagctgcc tcagctgcag gggtttctgt agcttttggt gcaccaattg   1500

gaggagttct ttttagcctg gaagaggtta gctattattt tcctctcaaa actttatgga   1560

gatcattttt tgctgcttta gtggctgcat ttgttttgag gtccatcaat ccatttggta   1620

acagccgtct ggtccttttt tatgtggagt atcatacacc atggtacctt tttgaactgt   1680

ttccttttat tcttctaggg gtatttggag ggctttgggg agcctttttc attagggcaa   1740

atattgcctg gtgtcgtcga cgcaagtcca cgaaatttgg aaagtatccc gttctggaag   1800

tcattattgt tgcagccatt actgctgtga tagccttccc taatccatac actaggctaa   1860

acaccagtga actgatcaaa gagcttttta cagactgtgg tcccctggaa tcctcttctc   1920

tttgtgacta cagaaatgac atgaatgcca gtaaaattgt cgatgacatt cctgatcgtc   1980

cagcaggcat tggagtatat tcagctatat ggcagttatg cctggcactc atatttaaaa   2040

tcataatgac agtattcact tttggcatca aggttccatc aggcttgttc atccccagca   2100

tggccattgg agcgatcgca ggaaggattg tggggattgc ggtggagcag cttgcctact   2160

atcaccacga ctggtttatc tttaaggagt ggtgtgaggt cggggctgat tgcattacac   2220

ctggccttta tgccatggtt ggtgctgctg catgcttagg tggtgtgaca agaatgactg   2280

tctccctggt ggttattgtt tttgagctta ctggaggctt ggaatatatt gttcccctta   2340

tggctgcagt catgaccagt aaatgggttg gagatgcctt tggcagggaa ggcatttatg   2400

aagcacacat ccgattaaat ggataccctt tcttggatgc aaaagaagaa ttcactcata   2460

ccaccctggc tgctgacgtt atgagacctc gaaggaatga tcctccctta gctgtcctga   2520

cacaggacaa tatgacagtg gatgatatag aaaacatgat taatgaaacc agctacaatg   2580

gatttcctgt cataatgtca aaagaatctc agagattagt gggatttgcc ctcagaagag   2640

acctgacaat tgcaatagaa agtgccagga aaaaacaaga aggtatcgtt ggcagttctc   2700

gggtgtgttt tgcacagcac accccatctc ttccagcaga aagtcctcgg ccattgaagc   2760

ttcgaagcat tcttgacatg agccctttta cagtgacaga ccacacccca atggagatcg   2820

tggtggatat tttccgaaag ctgggactga ggcagtgcct tgtaactcac aatgggcgcc   2880

tccttggcat tataacaaaa aaagatatcc tccggcatat ggcccagacg gcaaaccaag   2940

accccgcttc aataatgttc aactgaatct cacagatgag gagagagaag aaacggaaga   3000

ggaagtttat ttgttgaata gcacaactct ttaacctgag ggagtcatct actttttttt   3060

cctcctttac aaaaaaagaa aggaaatata aaagccgggt ttttgcaaca tggtttgcaa   3120

ataatgctgg tggaatggag gagttgtttg gggagggaaa ggagagagaa ggaaaggagt   3180

gaggtatttc ccgtctaaca gaaagcagcg tatcaactcc tattgttctg cactggatgc   3240

attcagctga ggatgtgcct gatagtgcag gcttgcgcct caacagagat gacagcagag   3300

tcctcgagca cctggcctgt tgctccaaca ttgcaaagac acattatcag tccctatttc   3360

tagagggatt actttgaatt gagccatcta taaaactgca aggtcttgcc ctttttttta   3420

atcaaaactg ttctgtttaa ttcatgaatt gtatagttaa gcattacctt tctacattcc   3480

agaagagcct ttatttctct ctctctctct ctctctctct ctctctctac tgagctgtaa   3540

caaagcctct ttaaatcggt gtatcctttt gaagcagtcc tttctcatat tgagatgtac   3600

tgtgatttta ctgaggtttc atcacaagaa gggagtgttt cttgtgccat taaccatgta   3660

gtttgtacca tcactaaatg cttggaacag tacacatgca ccacaacaaa ggctcatcaa   3720

acaggtaaag tctcgaagga agcgagaacg aaatctctca ttgtgtgccg tgtggctcaa   3780

aaccgaaaac aatgaagctt ggttttaaag gataaagttt tcttttttgt tttcctctca   3840

gactttatgg ataatgtgac cgggtcttat gcaaattttc tatttctaaa actactacta   3900

tgatatacaa gtgctgttga gcataattaa ataaaatgct gctgctttga cagtaaagag   3960

aaggaagtat tctgaaaaaa aa                                            3982


<210>  722
<211>  818
<212>  PRT
<213>  Homosapiens

<400>  722

Met Glu Ser Glu Gln Leu Phe His Arg Gly Tyr Tyr Arg Asn Ser Tyr 
1               5                   10                  15      


Asn Ser Ile Thr Ser Ala Ser Ser Asp Glu Glu Leu Leu Asp Gly Ala 
            20                  25                  30          


Gly Val Ile Met Asp Phe Gln Thr Ser Glu Asp Asp Asn Leu Leu Asp 
        35                  40                  45              


Gly Asp Thr Ala Val Gly Thr His Tyr Thr Met Thr Asn Gly Gly Ser 
    50                  55                  60                  


Ile Asn Ser Ser Thr His Leu Leu Asp Leu Leu Asp Glu Pro Ile Pro 
65                  70                  75                  80  


Gly Val Gly Thr Tyr Asp Asp Phe His Thr Ile Asp Trp Val Arg Glu 
                85                  90                  95      


Lys Cys Lys Asp Arg Glu Arg His Arg Arg Ile Asn Ser Lys Lys Lys 
            100                 105                 110         


Glu Ser Ala Trp Glu Met Thr Lys Ser Leu Tyr Asp Ala Trp Ser Gly 
        115                 120                 125             


Trp Leu Val Val Thr Leu Thr Gly Leu Ala Ser Gly Ala Leu Ala Gly 
    130                 135                 140                 


Leu Ile Asp Ile Ala Ala Asp Trp Met Thr Asp Leu Lys Glu Gly Ile 
145                 150                 155                 160 


Cys Leu Ser Ala Leu Trp Tyr Asn His Glu Gln Cys Cys Trp Gly Ser 
                165                 170                 175     


Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys Cys Pro Gln Trp Lys Thr 
            180                 185                 190         


Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu Gly Pro Gly Ser Tyr Ile 
        195                 200                 205             


Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala Leu Ser Phe Ala Phe Leu 
    210                 215                 220                 


Ala Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly 
225                 230                 235                 240 


Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr 
                245                 250                 255     


Leu Gly Lys Trp Thr Leu Met Ile Lys Thr Ile Thr Leu Val Leu Ala 
            260                 265                 270         


Val Ala Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val 
        275                 280                 285             


Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr Leu Phe Pro Lys Tyr Ser 
    290                 295                 300                 


Thr Asn Glu Ala Lys Lys Arg Glu Val Leu Ser Ala Ala Ser Ala Ala 
305                 310                 315                 320 


Gly Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser 
                325                 330                 335     


Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser 
            340                 345                 350         


Phe Phe Ala Ala Leu Val Ala Ala Phe Val Leu Arg Ser Ile Asn Pro 
        355                 360                 365             


Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Tyr His Thr Pro 
    370                 375                 380                 


Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile Leu Leu Gly Val Phe Gly 
385                 390                 395                 400 


Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala Asn Ile Ala Trp Cys Arg 
                405                 410                 415     


Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr Pro Val Leu Glu Val Ile 
            420                 425                 430         


Ile Val Ala Ala Ile Thr Ala Val Ile Ala Phe Pro Asn Pro Tyr Thr 
        435                 440                 445             


Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu Leu Phe Thr Asp Cys Gly 
    450                 455                 460                 


Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr Arg Asn Asp Met Asn Ala 
465                 470                 475                 480 


Ser Lys Ile Val Asp Asp Ile Pro Asp Arg Pro Ala Gly Ile Gly Val 
                485                 490                 495     


Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala Leu Ile Phe Lys Ile Ile 
            500                 505                 510         


Met Thr Val Phe Thr Phe Gly Ile Lys Val Pro Ser Gly Leu Phe Ile 
        515                 520                 525             


Pro Ser Met Ala Ile Gly Ala Ile Ala Gly Arg Ile Val Gly Ile Ala 
    530                 535                 540                 


Val Glu Gln Leu Ala Tyr Tyr His His Asp Trp Phe Ile Phe Lys Glu 
545                 550                 555                 560 


Trp Cys Glu Val Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met 
                565                 570                 575     


Val Gly Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser 
            580                 585                 590         


Leu Val Val Ile Val Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val 
        595                 600                 605             


Pro Leu Met Ala Ala Val Met Thr Ser Lys Trp Val Gly Asp Ala Phe 
    610                 615                 620                 


Gly Arg Glu Gly Ile Tyr Glu Ala His Ile Arg Leu Asn Gly Tyr Pro 
625                 630                 635                 640 


Phe Leu Asp Ala Lys Glu Glu Phe Thr His Thr Thr Leu Ala Ala Asp 
                645                 650                 655     


Val Met Arg Pro Arg Arg Asn Asp Pro Pro Leu Ala Val Leu Thr Gln 
            660                 665                 670         


Asp Asn Met Thr Val Asp Asp Ile Glu Asn Met Ile Asn Glu Thr Ser 
        675                 680                 685             


Tyr Asn Gly Phe Pro Val Ile Met Ser Lys Glu Ser Gln Arg Leu Val 
    690                 695                 700                 


Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile Ala Ile Glu Ser Ala Arg 
705                 710                 715                 720 


Lys Lys Gln Glu Gly Ile Val Gly Ser Ser Arg Val Cys Phe Ala Gln 
                725                 730                 735     


His Thr Pro Ser Leu Pro Ala Glu Ser Pro Arg Pro Leu Lys Leu Arg 
            740                 745                 750         


Ser Ile Leu Asp Met Ser Pro Phe Thr Val Thr Asp His Thr Pro Met 
        755                 760                 765             


Glu Ile Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu 
    770                 775                 780                 


Val Thr His Asn Gly Arg Leu Leu Gly Ile Ile Thr Lys Lys Asp Ile 
785                 790                 795                 800 


Leu Arg His Met Ala Gln Thr Ala Asn Gln Asp Pro Ala Ser Ile Met 
                805                 810                 815     


Phe Asn 
        


<210>  723
<211>  4058
<212>  DNA
<213>  Homosapiens

<400>  723
gccgcttctc ttccccttcc gtgggtcagg gccggtccgg tccggaacct gcagcccctt     60

tcccagtgtt ctagttcgcc cgtgacccgg aataatgagc aaggagggtg tggtgggttg    120

aaagccatcc tactttactc ccgagttaga gcatggattc agttttagtc ttaaggggga    180

agtgagattg gagattttta tttttaattt tgggcagaag caggttgact ctagggatct    240

ccagagcgag aggatttaac ttcatgttgc tcccgtgttt gaaggaggac aataaaagtc    300

ccaccgggca aaattttcgt aacctctgcg gtagaaaacg tcaggtatct tttaaatcgc    360

gatagttttc gctgtgtcag gctttcttcg gtggagctcc gagggtagct aggttctagg    420

tttgaaacag atgcagaatc caaaggcagc gcaaaaaaca gccaccgatt ttgctatgtc    480

tctgagctgc gagataatca gacagctaaa tggagtctga gcagctgttc catagaggct    540

actatagaaa cagctacaac agtataacaa gtgcaagtag tgatgaggaa cttttagatg    600

gagcaggtgt tattatggac tttcaaacat ctgaagatga caatttatta gatggtgaca    660

ctgcagttgg aactcattat acaatgacaa atggaggcag cattaacagt tctacacatt    720

tactggatct tttggatgaa ccaattccag gtgttggtac atatgatgat ttccatacta    780

ttgattgggt gcgagaaaaa tgtaaagaca gagaaaggca tagacggatc aacagcaaaa    840

agaaagaatc agcatgggaa atgacaaaaa gtttgtatga tgcgtggtca ggatggctag    900

tagtaacact aacaggattg gcatcagggg cactggccgg attaatagac attgctgccg    960

attggatgac tgacctaaag gagggcattt gccttagtgc gttgtggtac aaccacgaac   1020

agtgctgttg gggatctaat gaaacaacat ttgaagagag ggataaatgt ccacagtgga   1080

aaacatgggc agaattaatc ataggtcaag cagagggtcc tggttcttat atcatgaact   1140

acataatgta catcttctgg gccttgagtt ttgcctttct tgcagtttcc ctggtaaagg   1200

tatttgctcc atatgcctgt ggctctggaa ttccagagat taaaactatt ttaagtggat   1260

tcatcatcag aggttacttg ggaaaatgga ctttaatgat taaaaccatc acattagtcc   1320

tggctgtggc atcaggtttg agtttaggaa aagaaggtcc cctggtacat gttgcctgtt   1380

gctgcggaaa tatcttttcc tacctctttc caaagtatag cacaaacgaa gctaaaaaaa   1440

gggaggtgct atcagctgcc tcagctgcag gggtttctgt agcttttggt gcaccaattg   1500

gaggagttct ttttagcctg gaagaggtta gctattattt tcctctcaaa actttatgga   1560

gatcattttt tgctgcttta gtggctgcat ttgttttgag gtccatcaat ccatttggta   1620

acagccgtct ggtccttttt tatgtggagt atcatacacc atggtacctt tttgaactgt   1680

ttccttttat tcttctaggg gtatttggag ggctttgggg agcctttttc attagggcaa   1740

atattgcctg gtgtcgtcga cgcaagtcca cgaaatttgg aaagtatccc gttctggaag   1800

tcattattgt tgcagccatt actgctgtga tagccttccc taatccatac actaggctaa   1860

acaccagtga actgatcaaa gagcttttta cagactgtgg tcccctggaa tcctcttctc   1920

tttgtgacta cagaaatgac atgaatgcca gtaaaattgt cgatgacatt cctgatcgtc   1980

cagcaggcat tggagtatat tcagctatat ggcagttatg cctggcactc atatttaaaa   2040

tcataatgac agtattcact tttggcatca aggttccatc aggcttgttc atccccagca   2100

tggccattgg agcgatcgca ggaaggattg tggggattgc ggtggagcag cttgcctact   2160

atcaccacga ctggtttatc tttaaggagt ggtgtgaggt cggggctgat tgcattacac   2220

ctggccttta tgccatggtt ggtgctgctg catgcttagg tggtgtgaca agaatgactg   2280

tctccctggt ggttattgtt tttgagctta ctggaggctt ggaatatatt gttcccctta   2340

tggctgcagt catgaccagt aaatgggttg gagatgcctt tggcagggaa ggcatttatg   2400

aagcacacat ccgattaaat ggataccctt tcttggatgc aaaagaagaa ttcactcata   2460

ccaccctggc tgctgacgtt atgagacctc gaaggaatga tcctccctta gctgtcctga   2520

cacaggacaa tatgacagtg gatgatatag aaaacatgat taatgaaacc agctacaatg   2580

gatttcctgt cataatgtca aaagaatctc agagattagt gggatttgcc ctcagaagag   2640

acctgacaat tgcaatagaa agtgccagga aaaaacaaga aggtatcgtt ggcagttctc   2700

gggtgtgttt tgcacagcac accccatctc ttccagcaga aagtcctcgg ccattgaagc   2760

ttcgaagcat tcttgacatg agccctttta cagtgacaga ccacacccca atggagatcg   2820

tggtggatat tttccgaaag ctgggactga ggcagtgcct tgtaactcac aatgggattg   2880

tcttggggat catcacaaag aagaacatat tagagcatct cgagcaacta aagcagcacg   2940

tcgaaccctt ggcgcctcct tggcattata acaaaaaaag atatcctccg gcatatggcc   3000

cagacggcaa accaagaccc cgcttcaata atgttcaact gaatctcaca gatgaggaga   3060

gagaagaaac ggaagaggaa gtttatttgt tgaatagcac aactctttaa cctgagggag   3120

tcatctactt ttttttcctc ctttacaaaa aaagaaagga aatataaaag ccgggttttt   3180

gcaacatggt ttgcaaataa tgctggtgga atggaggagt tgtttgggga gggaaaggag   3240

agagaaggaa aggagtgagg tatttcccgt ctaacagaaa gcagcgtatc aactcctatt   3300

gttctgcact ggatgcattc agctgaggat gtgcctgata gtgcaggctt gcgcctcaac   3360

agagatgaca gcagagtcct cgagcacctg gcctgttgct ccaacattgc aaagacacat   3420

tatcagtccc tatttctaga gggattactt tgaattgagc catctataaa actgcaaggt   3480

cttgcccttt tttttaatca aaactgttct gtttaattca tgaattgtat agttaagcat   3540

tacctttcta cattccagaa gagcctttat ttctctctct ctctctctct ctctctctct   3600

ctctactgag ctgtaacaaa gcctctttaa atcggtgtat ccttttgaag cagtcctttc   3660

tcatattgag atgtactgtg attttactga ggtttcatca caagaaggga gtgtttcttg   3720

tgccattaac catgtagttt gtaccatcac taaatgcttg gaacagtaca catgcaccac   3780

aacaaaggct catcaaacag gtaaagtctc gaaggaagcg agaacgaaat ctctcattgt   3840

gtgccgtgtg gctcaaaacc gaaaacaatg aagcttggtt ttaaaggata aagttttctt   3900

ttttgttttc ctctcagact ttatggataa tgtgaccggg tcttatgcaa attttctatt   3960

tctaaaacta ctactatgat atacaagtgc tgttgagcat aattaaataa aatgctgctg   4020

ctttgacagt aaagagaagg aagtattctg aaaaaaaa                           4058


<210>  724
<211>  866
<212>  PRT
<213>  Homosapiens

<400>  724

Met Glu Ser Glu Gln Leu Phe His Arg Gly Tyr Tyr Arg Asn Ser Tyr 
1               5                   10                  15      


Asn Ser Ile Thr Ser Ala Ser Ser Asp Glu Glu Leu Leu Asp Gly Ala 
            20                  25                  30          


Gly Val Ile Met Asp Phe Gln Thr Ser Glu Asp Asp Asn Leu Leu Asp 
        35                  40                  45              


Gly Asp Thr Ala Val Gly Thr His Tyr Thr Met Thr Asn Gly Gly Ser 
    50                  55                  60                  


Ile Asn Ser Ser Thr His Leu Leu Asp Leu Leu Asp Glu Pro Ile Pro 
65                  70                  75                  80  


Gly Val Gly Thr Tyr Asp Asp Phe His Thr Ile Asp Trp Val Arg Glu 
                85                  90                  95      


Lys Cys Lys Asp Arg Glu Arg His Arg Arg Ile Asn Ser Lys Lys Lys 
            100                 105                 110         


Glu Ser Ala Trp Glu Met Thr Lys Ser Leu Tyr Asp Ala Trp Ser Gly 
        115                 120                 125             


Trp Leu Val Val Thr Leu Thr Gly Leu Ala Ser Gly Ala Leu Ala Gly 
    130                 135                 140                 


Leu Ile Asp Ile Ala Ala Asp Trp Met Thr Asp Leu Lys Glu Gly Ile 
145                 150                 155                 160 


Cys Leu Ser Ala Leu Trp Tyr Asn His Glu Gln Cys Cys Trp Gly Ser 
                165                 170                 175     


Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys Cys Pro Gln Trp Lys Thr 
            180                 185                 190         


Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu Gly Pro Gly Ser Tyr Ile 
        195                 200                 205             


Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala Leu Ser Phe Ala Phe Leu 
    210                 215                 220                 


Ala Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly 
225                 230                 235                 240 


Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr 
                245                 250                 255     


Leu Gly Lys Trp Thr Leu Met Ile Lys Thr Ile Thr Leu Val Leu Ala 
            260                 265                 270         


Val Ala Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val 
        275                 280                 285             


Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr Leu Phe Pro Lys Tyr Ser 
    290                 295                 300                 


Thr Asn Glu Ala Lys Lys Arg Glu Val Leu Ser Ala Ala Ser Ala Ala 
305                 310                 315                 320 


Gly Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser 
                325                 330                 335     


Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser 
            340                 345                 350         


Phe Phe Ala Ala Leu Val Ala Ala Phe Val Leu Arg Ser Ile Asn Pro 
        355                 360                 365             


Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Tyr His Thr Pro 
    370                 375                 380                 


Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile Leu Leu Gly Val Phe Gly 
385                 390                 395                 400 


Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala Asn Ile Ala Trp Cys Arg 
                405                 410                 415     


Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr Pro Val Leu Glu Val Ile 
            420                 425                 430         


Ile Val Ala Ala Ile Thr Ala Val Ile Ala Phe Pro Asn Pro Tyr Thr 
        435                 440                 445             


Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu Leu Phe Thr Asp Cys Gly 
    450                 455                 460                 


Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr Arg Asn Asp Met Asn Ala 
465                 470                 475                 480 


Ser Lys Ile Val Asp Asp Ile Pro Asp Arg Pro Ala Gly Ile Gly Val 
                485                 490                 495     


Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala Leu Ile Phe Lys Ile Ile 
            500                 505                 510         


Met Thr Val Phe Thr Phe Gly Ile Lys Val Pro Ser Gly Leu Phe Ile 
        515                 520                 525             


Pro Ser Met Ala Ile Gly Ala Ile Ala Gly Arg Ile Val Gly Ile Ala 
    530                 535                 540                 


Val Glu Gln Leu Ala Tyr Tyr His His Asp Trp Phe Ile Phe Lys Glu 
545                 550                 555                 560 


Trp Cys Glu Val Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met 
                565                 570                 575     


Val Gly Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser 
            580                 585                 590         


Leu Val Val Ile Val Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val 
        595                 600                 605             


Pro Leu Met Ala Ala Val Met Thr Ser Lys Trp Val Gly Asp Ala Phe 
    610                 615                 620                 


Gly Arg Glu Gly Ile Tyr Glu Ala His Ile Arg Leu Asn Gly Tyr Pro 
625                 630                 635                 640 


Phe Leu Asp Ala Lys Glu Glu Phe Thr His Thr Thr Leu Ala Ala Asp 
                645                 650                 655     


Val Met Arg Pro Arg Arg Asn Asp Pro Pro Leu Ala Val Leu Thr Gln 
            660                 665                 670         


Asp Asn Met Thr Val Asp Asp Ile Glu Asn Met Ile Asn Glu Thr Ser 
        675                 680                 685             


Tyr Asn Gly Phe Pro Val Ile Met Ser Lys Glu Ser Gln Arg Leu Val 
    690                 695                 700                 


Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile Ala Ile Glu Ser Ala Arg 
705                 710                 715                 720 


Lys Lys Gln Glu Gly Ile Val Gly Ser Ser Arg Val Cys Phe Ala Gln 
                725                 730                 735     


His Thr Pro Ser Leu Pro Ala Glu Ser Pro Arg Pro Leu Lys Leu Arg 
            740                 745                 750         


Ser Ile Leu Asp Met Ser Pro Phe Thr Val Thr Asp His Thr Pro Met 
        755                 760                 765             


Glu Ile Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu 
    770                 775                 780                 


Val Thr His Asn Gly Ile Val Leu Gly Ile Ile Thr Lys Lys Asn Ile 
785                 790                 795                 800 


Leu Glu His Leu Glu Gln Leu Lys Gln His Val Glu Pro Leu Ala Pro 
                805                 810                 815     


Pro Trp His Tyr Asn Lys Lys Arg Tyr Pro Pro Ala Tyr Gly Pro Asp 
            820                 825                 830         


Gly Lys Pro Arg Pro Arg Phe Asn Asn Val Gln Leu Asn Leu Thr Asp 
        835                 840                 845             


Glu Glu Arg Glu Glu Thr Glu Glu Glu Val Tyr Leu Leu Asn Ser Thr 
    850                 855                 860                 


Thr Leu 
865     


<210>  725
<211>  1188
<212>  DNA
<213>  Homosapiens

<400>  725
gctggcgctg cagctgcaga atggtcggcg gtggcgggaa gcgcaggccc ggcggggagg     60

ggccgcagtg tgaaaaaaca actgatgtga agaaaagtaa attctgtgaa gctgatgtct    120

ccagtgacct tcgaaaagaa gtagaaaatc attataagct ttctttacct gaagatttct    180

atcacttctg gaagttctgt gaagaacttg atcctgaaaa gccatctgat tcactttctg    240

caagccttgg acttcaatta gttggtcctt atgatatcct tgctggaaaa cataaaacga    300

agaaaaaatc aacaggcctg aattttaacc ttcactggag gttttactat gatcctcctg    360

agttccagac cattattatc ggagataata aaactcagta ccacatgggg tatttcaggg    420

attctcctga tgaatttcct gtatatgttg gtataaatga agcaaagaaa aattgtataa    480

ttgttccaaa tggagataat gtatttgctg cagtcaaatt atttttgacg aaaaaactta    540

aagaaataac ggataaaaag aaaatcaatc tcttgaaaaa catagatgaa aaactcacag    600

aagcagccag agaattgggg tactcgcttg aacagagaac cgtgaagatg aaacagagag    660

ataagaaagt tgtgacaaag acctttcatg gtgcaggctt ggttgttcca gtagataaaa    720

atgatgttgg gtaccgagag ctccctgaaa cagatgctga cctcaagaga atttgcaaga    780

caatagttga ggctgcaagt gatgaggaga gactaaaagc ttttgctccc attcaggaaa    840

tgatgacttt tgtgcagttt gctaatgatg aatgtgatta tggcatgggg cttgaattgg    900

gaatggatct cttttgctat ggctcacatt attttcataa agttgctggc cagcttttac    960

ctcttgcata taatctgttg aagaggaatc tgtttgcaga aattattgag gagcatctgg   1020

caaacagaag tcaagagaac atagaccaac ttgctgcatg agtaaggtgg ctttgattgg   1080

tgtacagtat ttcaaaggac tagtattaaa cttgtgattt ttgttttgtt tttaaggaat   1140

acaaaaaata aacatttact aaaaacgttt aaaaaaaaaa aaaaaaaa                1188


<210>  726
<211>  346
<212>  PRT
<213>  Homosapiens

<400>  726

Met Val Gly Gly Gly Gly Lys Arg Arg Pro Gly Gly Glu Gly Pro Gln 
1               5                   10                  15      


Cys Glu Lys Thr Thr Asp Val Lys Lys Ser Lys Phe Cys Glu Ala Asp 
            20                  25                  30          


Val Ser Ser Asp Leu Arg Lys Glu Val Glu Asn His Tyr Lys Leu Ser 
        35                  40                  45              


Leu Pro Glu Asp Phe Tyr His Phe Trp Lys Phe Cys Glu Glu Leu Asp 
    50                  55                  60                  


Pro Glu Lys Pro Ser Asp Ser Leu Ser Ala Ser Leu Gly Leu Gln Leu 
65                  70                  75                  80  


Val Gly Pro Tyr Asp Ile Leu Ala Gly Lys His Lys Thr Lys Lys Lys 
                85                  90                  95      


Ser Thr Gly Leu Asn Phe Asn Leu His Trp Arg Phe Tyr Tyr Asp Pro 
            100                 105                 110         


Pro Glu Phe Gln Thr Ile Ile Ile Gly Asp Asn Lys Thr Gln Tyr His 
        115                 120                 125             


Met Gly Tyr Phe Arg Asp Ser Pro Asp Glu Phe Pro Val Tyr Val Gly 
    130                 135                 140                 


Ile Asn Glu Ala Lys Lys Asn Cys Ile Ile Val Pro Asn Gly Asp Asn 
145                 150                 155                 160 


Val Phe Ala Ala Val Lys Leu Phe Leu Thr Lys Lys Leu Lys Glu Ile 
                165                 170                 175     


Thr Asp Lys Lys Lys Ile Asn Leu Leu Lys Asn Ile Asp Glu Lys Leu 
            180                 185                 190         


Thr Glu Ala Ala Arg Glu Leu Gly Tyr Ser Leu Glu Gln Arg Thr Val 
        195                 200                 205             


Lys Met Lys Gln Arg Asp Lys Lys Val Val Thr Lys Thr Phe His Gly 
    210                 215                 220                 


Ala Gly Leu Val Val Pro Val Asp Lys Asn Asp Val Gly Tyr Arg Glu 
225                 230                 235                 240 


Leu Pro Glu Thr Asp Ala Asp Leu Lys Arg Ile Cys Lys Thr Ile Val 
                245                 250                 255     


Glu Ala Ala Ser Asp Glu Glu Arg Leu Lys Ala Phe Ala Pro Ile Gln 
            260                 265                 270         


Glu Met Met Thr Phe Val Gln Phe Ala Asn Asp Glu Cys Asp Tyr Gly 
        275                 280                 285             


Met Gly Leu Glu Leu Gly Met Asp Leu Phe Cys Tyr Gly Ser His Tyr 
    290                 295                 300                 


Phe His Lys Val Ala Gly Gln Leu Leu Pro Leu Ala Tyr Asn Leu Leu 
305                 310                 315                 320 


Lys Arg Asn Leu Phe Ala Glu Ile Ile Glu Glu His Leu Ala Asn Arg 
                325                 330                 335     


Ser Gln Glu Asn Ile Asp Gln Leu Ala Ala 
            340                 345     


<210>  727
<211>  1003
<212>  DNA
<213>  Homosapiens

<400>  727
ctgccgccgt cgcctgaggg gagcgagaag aggcagcggc gaccagggag aaaacgcgga     60

gtccccaccg gagagcagcc gccgccagac agccgcccgc ccacccgttc gcccgtcccc    120

ctgccgcatt cacaatgcag cctgcttttg caaagtggta cgatcgaagg gactgtgtct    180

tcactgaatc ttgtgttgaa gacaataagg atgttaatgt aaattttgaa aaatccaaac    240

ttacattcag ttgtcttgga ggaagtgata attttaagca tttaaatgaa attggtcttt    300

tttactctat tgatccaaat gattccaagc ataaaagaac ggacagatca attttatgtt    360

gtttacgaaa aggagaatct ggccagtcat ggccaaggtt aacaaaagaa agggcaaagc    420

ttaactggct tagtatggac ttcaatcatt ggaaagactg ggaagatggt tcagatgaag    480

acaggtctaa ttttgatcgt ttctccgaga tgatgaacaa catgggtggg gatgaggatg    540

tagatttacc agaagtagat gaagcaggtg atgattcaca agacagtgat gatgaaaaaa    600

tgccagatct ggagtaagaa atatttcatc acctggattt tgagaaagaa aataacttct    660

ctgcaagatt tcataattga gagaattcct cagttgatag ccctaaaggc agatgctgta    720

tttgcctact ttaacccatt tttcaacctg tttgtttttt aaaaggcttc actaagggtt    780

tatatgtacc attgtatgga gcaatttgaa gtcagctaag gcaataacct tatgcatgaa    840

catttcccag actttcatga agctgttgag gtcctaggca attgatgcag cagttgtgat    900

aaataaaaac atctcaccta agtctccttt tcttcataac atagatactg acgtgatagg    960

aagctctggg cttaggtaaa gagaacaaaa ttttagttta tag                     1003


<210>  728
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  728

Met Gln Pro Ala Phe Ala Lys Trp Tyr Asp Arg Arg Asp Cys Val Phe 
1               5                   10                  15      


Thr Glu Ser Cys Val Glu Asp Asn Lys Asp Val Asn Val Asn Phe Glu 
            20                  25                  30          


Lys Ser Lys Leu Thr Phe Ser Cys Leu Gly Gly Ser Asp Asn Phe Lys 
        35                  40                  45              


His Leu Asn Glu Ile Gly Leu Phe Tyr Ser Ile Asp Pro Asn Asp Ser 
    50                  55                  60                  


Lys His Lys Arg Thr Asp Arg Ser Ile Leu Cys Cys Leu Arg Lys Gly 
65                  70                  75                  80  


Glu Ser Gly Gln Ser Trp Pro Arg Leu Thr Lys Glu Arg Ala Lys Leu 
                85                  90                  95      


Asn Trp Leu Ser Met Asp Phe Asn His Trp Lys Asp Trp Glu Asp Gly 
            100                 105                 110         


Ser Asp Glu Asp Arg Ser Asn Phe Asp Arg Phe Ser Glu Met Met Asn 
        115                 120                 125             


Asn Met Gly Gly Asp Glu Asp Val Asp Leu Pro Glu Val Asp Glu Ala 
    130                 135                 140                 


Gly Asp Asp Ser Gln Asp Ser Asp Asp Glu Lys Met Pro Asp Leu Glu 
145                 150                 155                 160 


<210>  729
<211>  1336
<212>  DNA
<213>  Homosapiens

<400>  729
gtcagtcgcg agcgaacgac caagagggtg ttcgactgct agagccgagc gaagcgatgc     60

ctaaatcaaa ggaacttgtt tcttcaggct cttctggcag tgattctgac agtgaggttg    120

acaaaaagtt aaagaggaaa aagcaagttg ctccagaaaa acctgtaaag aaacaaaaga    180

caggtgagac ttcgagagcc ctgtcatctt ctaaacagag cagcagcagc agagatgata    240

acatgtttca gattgggaaa atgaggtacg ttagtgttcg cgattttaaa ggcaaagtgc    300

taattgatat tagagaatat tggatggatc ctgaaggtga aatgaaacca ggaagaaaag    360

gtatttcttt aaatccagaa caatggagcc agctgaagga acagatttct gacattgatg    420

atgcagtaag aaaactgtaa aattcgagcc atataaataa aacctgtact gttctagttg    480

ttttaatctg tctttttaca ttagcttttg ttttctaaat gttctccaag ctattgtatg    540

tttggattgc agaagaattt gtaagatgaa tacttttttt taatgtgcat tattaaaaat    600

attgagtgaa gctaattgtc aactttatta aggattactt tgtctgccca ccacctagtg    660

taaaataaaa tcaagtaata caatcttaac tgttgtggcc ttttttgatc ataagagttg    720

gtactgttta aggccaaaag taacagtttt tatagatctt ttagtttcaa ctcagctttt    780

acaataaaaa ggatttgtat tgcattgagt ttataaactt ttggtttgtg aacttcatat    840

ttgatctttt ctcttccaat caaatgtcta ggcttgtttg acttccaccc ccaatggttt    900

ttcactcttt ttatttactt cattttcctt taataactta atctcttcat gttcagtttt    960

tacttcactc tttattcttt tctttgatta tggtatgctt atttggaaag tcagtgaaac   1020

tgtcaaaatg ttatctcaat aagatactta tatgagaact acaatcaccg aatctactgt   1080

attcaatatt agcagatcta atttgataaa caacatggct tgtgtgaaaa ctgagcaggt   1140

gtttgtttac ccatagtgtt ctgtgtagtt attgcttagt ctgcagaaaa taatgactta   1200

gatgagatgt ctgacttgct ttcacttatt aaacatgttc accatgggat gatgtctgta   1260

acatcagata ttgttcaact agactaggat ttaataaaaa ttgtgaaagc ttaaaaaaaa   1320

aaaaaaaaaa aaaaaa                                                   1336


<210>  730
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  730

Met Pro Lys Ser Lys Glu Leu Val Ser Ser Gly Ser Ser Gly Ser Asp 
1               5                   10                  15      


Ser Asp Ser Glu Val Asp Lys Lys Leu Lys Arg Lys Lys Gln Val Ala 
            20                  25                  30          


Pro Glu Lys Pro Val Lys Lys Gln Lys Thr Gly Glu Thr Ser Arg Ala 
        35                  40                  45              


Leu Ser Ser Ser Lys Gln Ser Ser Ser Ser Arg Asp Asp Asn Met Phe 
    50                  55                  60                  


Gln Ile Gly Lys Met Arg Tyr Val Ser Val Arg Asp Phe Lys Gly Lys 
65                  70                  75                  80  


Val Leu Ile Asp Ile Arg Glu Tyr Trp Met Asp Pro Glu Gly Glu Met 
                85                  90                  95      


Lys Pro Gly Arg Lys Gly Ile Ser Leu Asn Pro Glu Gln Trp Ser Gln 
            100                 105                 110         


Leu Lys Glu Gln Ile Ser Asp Ile Asp Asp Ala Val Arg Lys Leu 
        115                 120                 125         


<210>  731
<211>  2651
<212>  DNA
<213>  Homosapiens

<400>  731
tctttttctt ttttttttaa gaaaaactag tgacattgca gagaaggacg cttcctctct     60

atcttttggc gcattagtga agggggtatt ctattttgtt aaagcgccca agggggcgca    120

gggaccttgg agagaagagt ggggaggaaa gaggaagggt gggtgggggg cagagggcga    180

gtcggcggcg gcgagggcaa gctctttctt gcggcacgat gccgtctctg ctggtgctca    240

ctttctcccc gtgcgtacta ctcggctggg cgttgctggc cggcggcacc ggtggcggtg    300

gcgttggcgg cggcggcggt ggcgcgggca taggcggcgg acgccaggag agagaggcgc    360

tgccgccaca gaagatcgag gtgctggtgt tactgcccca ggatgactcg tacttgtttt    420

cactcacccg ggtgcggccg gccatcgagt atgctctgcg cagcgtggag ggcaacggga    480

ctgggaggcg gcttctgccg ccgggcactc gcttccaggt ggcttacgag gattcagact    540

gtgggaaccg tgcgctcttc agcttggtgg accgcgtggc ggcggcgcgg ggcgccaagc    600

cagaccttat cctggggcca gtgtgcgagt atgcagcagc gccagtggcc cggcttgcat    660

cgcactggga cctgcccatg ctgtcggctg gggcgctggc cgctggcttc cagcacaagg    720

actctgagta ctcgcacctc acgcgcgtgg cgcccgccta cgccaagatg ggcgagatga    780

tgctcgccct gttccgccac caccactgga gccgcgctgc actggtctac agcgacgaca    840

agctggagcg gaactgctac ttcaccctcg agggggtcca cgaggtcttc caggaggagg    900

gtttgcacac gtccatctac agtttcgacg agaccaaaga cttggatctg gaagacatcg    960

tgcgcaatat ccaggccagt gagagagtgg tgatcatgtg tgcgagcagt gacaccatcc   1020

ggagcatcat gctggtggcg cacaggcatg gcatgaccag tggagactac gccttcttca   1080

acattgagct cttcaacagc tcttcctatg gagatggctc atggaagaga ggagacaaac   1140

acgactttga agctaagcaa gcatactcgt ccctccagac agtcactcta ctgaggacag   1200

tgaaacctga gtttgagaag ttttccatgg aggtgaaaag ttcagttgag aaacaagggc   1260

tcaatatgga ggattacgtt aacatgtttg ttgaaggatt ccacgatgcc atcctcctct   1320

acgtcttggc tctacatgaa gtactcagag ctggttacag caaaaaggat ggagggaaaa   1380

ttatacagca gacttggaac agaacatttg aaggtatcgc cgggcaggtg tccatagatg   1440

ccaacggaga ccgatatggg gatttctctg tgattgccat gactgatgtg gaggcgggca   1500

cccaggaggt tattggtgat tattttggaa aagaaggtcg ttttgaaatg cggccgaatg   1560

tcaaatatcc ttggggccct ttaaaactga gaatagatga aaaccgaatt gtagagcata   1620

caaacagctc tccctgcaaa tcatgtggcc tagaagaatc ggcagtgaca ggaattgtcg   1680

tgggggcttt actaggagct ggcttgctaa tggccttcta ctttttcagg aagaaataca   1740

gaataaccat tgagaggcga acccagcaag aagaaagtaa ccttggaaaa catcgggaat   1800

tacgggaaga ttccatcaga tcccattttt cagtagctta aaggaagccc cccacttttt   1860

ttttttctgc ctgagattct ttaaggagat agacgggttg aaagacatca atgaaacaga   1920

aggggcgttc ttgaagaatt cataatttta agcagttagt aatttcattt taaaatttct   1980

gtagaagctc aggaattatg attaatcacc atctgcctcc aggcctttca tctcatgaca   2040

aacaaatata ataatgatat cgtgtcactc tgttaaatgt tcatactgtt tcaagcccat   2100

atgattagat ttatgttttt aaaatctgtt gtctccatat cttgatggct tttgggagca   2160

tttcacacaa ggatataaaa tgcggttttc ttaaatgaaa tgttttgtag ctagaataaa   2220

atcattttta caagtacagc attcttggaa agaatttaac acccaaaaag gggaaaatgt   2280

aatgaaaaat ctcaaggttg gaaatacagc cttactctct ctagagctgg aggacaggtt   2340

tgtggttgag gacttctctg tccgatgtct acattcaggt tctgacttca tatcttgaaa   2400

aaggatttcc tccctgtctt tttcagtgtc tcataaacgc tactctggat tgttgtaaat   2460

attagtgaga tgggaggatt tacagaagaa aagcaagtca aaaatatttc ctttttgatg   2520

taaaaaaaaa aagccctatt tcgcactaac attttatttt acaagtattt taatcttata   2580

ttttggtatt agaaaaattt gtctattttt tcattttgaa gattaaatgt tgcttacatt   2640

ttaaaaaaaa a                                                        2651


<210>  732
<211>  540
<212>  PRT
<213>  Homosapiens

<400>  732

Met Pro Ser Leu Leu Val Leu Thr Phe Ser Pro Cys Val Leu Leu Gly 
1               5                   10                  15      


Trp Ala Leu Leu Ala Gly Gly Thr Gly Gly Gly Gly Val Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Ile Gly Gly Gly Arg Gln Glu Arg Glu Ala Leu 
        35                  40                  45              


Pro Pro Gln Lys Ile Glu Val Leu Val Leu Leu Pro Gln Asp Asp Ser 
    50                  55                  60                  


Tyr Leu Phe Ser Leu Thr Arg Val Arg Pro Ala Ile Glu Tyr Ala Leu 
65                  70                  75                  80  


Arg Ser Val Glu Gly Asn Gly Thr Gly Arg Arg Leu Leu Pro Pro Gly 
                85                  90                  95      


Thr Arg Phe Gln Val Ala Tyr Glu Asp Ser Asp Cys Gly Asn Arg Ala 
            100                 105                 110         


Leu Phe Ser Leu Val Asp Arg Val Ala Ala Ala Arg Gly Ala Lys Pro 
        115                 120                 125             


Asp Leu Ile Leu Gly Pro Val Cys Glu Tyr Ala Ala Ala Pro Val Ala 
    130                 135                 140                 


Arg Leu Ala Ser His Trp Asp Leu Pro Met Leu Ser Ala Gly Ala Leu 
145                 150                 155                 160 


Ala Ala Gly Phe Gln His Lys Asp Ser Glu Tyr Ser His Leu Thr Arg 
                165                 170                 175     


Val Ala Pro Ala Tyr Ala Lys Met Gly Glu Met Met Leu Ala Leu Phe 
            180                 185                 190         


Arg His His His Trp Ser Arg Ala Ala Leu Val Tyr Ser Asp Asp Lys 
        195                 200                 205             


Leu Glu Arg Asn Cys Tyr Phe Thr Leu Glu Gly Val His Glu Val Phe 
    210                 215                 220                 


Gln Glu Glu Gly Leu His Thr Ser Ile Tyr Ser Phe Asp Glu Thr Lys 
225                 230                 235                 240 


Asp Leu Asp Leu Glu Asp Ile Val Arg Asn Ile Gln Ala Ser Glu Arg 
                245                 250                 255     


Val Val Ile Met Cys Ala Ser Ser Asp Thr Ile Arg Ser Ile Met Leu 
            260                 265                 270         


Val Ala His Arg His Gly Met Thr Ser Gly Asp Tyr Ala Phe Phe Asn 
        275                 280                 285             


Ile Glu Leu Phe Asn Ser Ser Ser Tyr Gly Asp Gly Ser Trp Lys Arg 
    290                 295                 300                 


Gly Asp Lys His Asp Phe Glu Ala Lys Gln Ala Tyr Ser Ser Leu Gln 
305                 310                 315                 320 


Thr Val Thr Leu Leu Arg Thr Val Lys Pro Glu Phe Glu Lys Phe Ser 
                325                 330                 335     


Met Glu Val Lys Ser Ser Val Glu Lys Gln Gly Leu Asn Met Glu Asp 
            340                 345                 350         


Tyr Val Asn Met Phe Val Glu Gly Phe His Asp Ala Ile Leu Leu Tyr 
        355                 360                 365             


Val Leu Ala Leu His Glu Val Leu Arg Ala Gly Tyr Ser Lys Lys Asp 
    370                 375                 380                 


Gly Gly Lys Ile Ile Gln Gln Thr Trp Asn Arg Thr Phe Glu Gly Ile 
385                 390                 395                 400 


Ala Gly Gln Val Ser Ile Asp Ala Asn Gly Asp Arg Tyr Gly Asp Phe 
                405                 410                 415     


Ser Val Ile Ala Met Thr Asp Val Glu Ala Gly Thr Gln Glu Val Ile 
            420                 425                 430         


Gly Asp Tyr Phe Gly Lys Glu Gly Arg Phe Glu Met Arg Pro Asn Val 
        435                 440                 445             


Lys Tyr Pro Trp Gly Pro Leu Lys Leu Arg Ile Asp Glu Asn Arg Ile 
    450                 455                 460                 


Val Glu His Thr Asn Ser Ser Pro Cys Lys Ser Cys Gly Leu Glu Glu 
465                 470                 475                 480 


Ser Ala Val Thr Gly Ile Val Val Gly Ala Leu Leu Gly Ala Gly Leu 
                485                 490                 495     


Leu Met Ala Phe Tyr Phe Phe Arg Lys Lys Tyr Arg Ile Thr Ile Glu 
            500                 505                 510         


Arg Arg Thr Gln Gln Glu Glu Ser Asn Leu Gly Lys His Arg Glu Leu 
        515                 520                 525             


Arg Glu Asp Ser Ile Arg Ser His Phe Ser Val Ala 
    530                 535                 540 


<210>  733
<211>  2896
<212>  DNA
<213>  Homosapiens

<400>  733
catgtcagtc atctactttt tttctttgaa atctgcatat gggttacaaa aactctgtta     60

ggttttgaaa attccattaa gttggaaacc ttggttaaaa atgtaggtgc ctggcccatg    120

gttaccctgg attcaggtct ctcatgatta tatttgggga tttacgttcc taactgctaa    180

gcaacatctt tgacaactag taattcatac tctactagta gtcacatgtc atatagtaaa    240

ataaataggg ctttagttct taagtaattc tataggattt taccctgaaa tccagggtgt    300

tcagatttca aaaaggataa tttatcagta ttttctcatc cagtcaaact tcagctgaca    360

ttgatacagg tcaaaatgcg tagatgcttt ttggtgttgg aaataagtgt ctgtcttatg    420

gtcatcattg tcttcttaga tttttgggta ggggggccag gtagggggag actcagaaat    480

aaaagcgttc cccagataac ttcaatctgg aaagaatttt ttgtatagag tccatctctc    540

cctcaagact gaccacaggt ttcatgagaa ggtccctgaa aacatcacat ttctctgaag    600

aaccatcaac ttgtcttttc ttgaaccaca ggaatggttc tacagaccct actataattc    660

ttcacatttc agaacccatg tttaatggag ggaagagaga aatgcatggg aaaagaacac    720

ctccttttct cctttctctt aaattcaaag acgtttgctt tggaatgccc tcacttctcc    780

ctattcacag gcttctaaaa tcattaattt actcaaggca catgtgcctt ctttgcccca    840

aatgcatcac tttcctttta gttatggctg attttgggtg tgtgtgtgta agacatgcag    900

tcaacaatga gatgaaggcc attgcataga tctcatgcag atagtgatgg attcagaaag    960

taggttccag tggcgtcact accttcttgt aagccagtat acactggcta tttgtggaaa   1020

tctctttggg agatcaaata gagtattatg ccactgtgag tgtttataaa ctggaaggaa   1080

caagtacctg tgtttcttgg gacacaaagc actcagatcc tgagtggatg cagacatgag   1140

agtaaatgtc agcccaaatt aggcccctcg acctacagac atttcatggg ttttatttaa   1200

tcacacccca tggtttgggg ctacatgagg aagttggtaa tgagctgaat ttcttattca   1260

gtggaaaaaa ctgaaactgt ctaaaaacac gggatatatt ttagaggcaa ttgtggaagc   1320

ggagagaatg agatgatggt gttcagaggg accagcttct ttttcagttg tctttagaac   1380

tcaagaataa tcaataattt agtgcccctt caacagccat actcagcaag aagaatcaga   1440

agcttgatcc tctaacagaa atagaagagg gtagctttgc ccattgccac tgtctttact   1500

gccccttctg cccctccacc cacatccaca ttcagcatca ctccaaggat gtgtcagcat   1560

cttgcccatg caggtagaaa tttgtgagta ggcctccata cttcctcggg ggaagaaaga   1620

gaaactagtg ctggttttaa gaatgtagct ggcttttcat cagaaccctt atgctaacct   1680

gaccacactt gctctcgggg aagttcaagc ctgtgatgtg cataaactcc aacaagcctg   1740

gctttggtgt tcagcatgca cattccataa atatctcttg caggcatacc ccacagctag   1800

actgcaggat taaaataact tccaaaaggt gctggattgg agtttgttca aatttctcat   1860

taaccactaa tgttaattca taccaaatgc aaagtattct aaaccagctg atgctgtcag   1920

tgttcaagtt ttaagtgact tcaaacacaa tggaagtgtt tcaatgggag ccagatctca   1980

tgagtaaaaa tccattttat aatagctctg tgatatatca gtgggagatg attcataggg   2040

gagagatttg aacaagcaga attaagtgtt agcaaaaatg ctgcattgct ttgattcatg   2100

tttaaagacc taaatttcta tgcacaagga ataaagggcc tacttaccaa gtgtaaatca   2160

caacataggc taccaaaata tttcttattt gctaggagaa caaagctgtc acggtgcatg   2220

atagctggac agagatggct aaaaaagagg caaattcaga tttggaaaca gggtggcctc   2280

ttcattattt attgccaaga tctgaaaatc ttcaacatct tataagacaa caatgaagta   2340

gcccctgaac agcatggagt tgctgtgagt ttgttcgttg cagacctttg tgttgggtcc   2400

tgggaatcta agctttgttc cctgtgcatg gtggataatt gaaaccaaga ggacatggga   2460

tagaccttgt gacagaccaa ttctgtgacc cctgtcttct gggtcacatt attcattgtt   2520

gatttaaata caggactacc aaacagtaca aatctatcat gagtctggta gaaaagtaaa   2580

agtaaaagct gcacacgtta catactgttt attgttctaa tgtacaacta actatttgca   2640

tataatgtga tttaatttat tgctgttttg tgtagaaaag gagaactaat gactgtggat   2700

ataacccatg ttttgtataa tatattttat ttcttgtgcg aactggtcat ttaaaatatc   2760

tacttcattt gatgtttgga tataaatgtg tatgtgtcct tgtaaatgtt tctatcaagc   2820

aagaatgcca cgtactcaga gtataacaat gtgttctcat taaaaaatac atcccgaaaa   2880

aaaaaaaaaa aaaaaa                                                   2896


<210>  734
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  734

Met Arg Arg Ser Leu Lys Thr Ser His Phe Ser Glu Glu Pro Ser Thr 
1               5                   10                  15      


Cys Leu Phe Leu Asn His Arg Asn Gly Ser Thr Asp Pro Thr Ile Ile 
            20                  25                  30          


Leu His Ile Ser Glu Pro Met Phe Asn Gly Gly Lys Arg Glu Met His 
        35                  40                  45              


Gly Lys Arg Thr Pro Pro Phe Leu Leu Ser Leu Lys Phe Lys Asp Val 
    50                  55                  60                  


Cys Phe Gly Met Pro Ser Leu Leu Pro Ile His Arg Leu Leu Lys Ser 
65                  70                  75                  80  


Leu Ile Tyr Ser Arg His Met Cys Leu Leu Cys Pro Lys Cys Ile Thr 
                85                  90                  95      


Phe Leu Leu Val Met Ala Asp Phe Gly Cys Val Cys Val Arg His Ala 
            100                 105                 110         


Val Asn Asn Glu Met Lys Ala Ile Ala 
        115                 120     


<210>  735
<211>  1670
<212>  DNA
<213>  Homosapiens

<400>  735
gatttcctcc cacgcgacct tccagttctc ggagccaggt taggggtttg gcggaggagg     60

actgcggggc gcgggcctag ggccccagca gccacggcca ggggagcgct caagacagaa    120

agccggtggc ttcctcacct ccacctgtaa tgcaggaggg agaattggct atttctccta    180

taagccctgt ggcagccatg cctcccctag gcacccacgt gcaagccaga tgtgaagctc    240

aaattaacct gctgggtgaa ggggggatct gcaagctgcc aggaagactc cgcatccagc    300

ccgcactgtg gagcagggag gacgtgctgc actggctgcg ctgggcagag caggagtact    360

ctctgccatg caccgcggag cacgggttcg agatgaacgg acgcgccctc tgcatcctca    420

ccaaggacga cttccggcac cgtgcgccca gctcaggtga cgtcctgtat gagctgctcc    480

agtacatcaa gacccagcgg cgagccctgg tgtgtggacc cttttttgga gggatcttca    540

ggctgaagac gcccacccag cactctccag tccccccgga agaggtgact ggcccctctc    600

agatggacac ccgaaggggc cacctgctgc agccaccaga cccagggctt accagcaact    660

tcggccacct ggatgaccct ggcctggcaa ggtggacccc tggcaaggag gagtccctca    720

acttatgtca ctgtgcagag ctcggctgca ggacccaggg ggtctgttcc ttccccgcga    780

tgccgcaggc ccccattgac ggcaggatcg ctgactgccg cctgctgtgg gattacgtgt    840

atcagctgct ccttgatacc cgatatgagc cctacatcaa gtgggaagac aaggacgcca    900

agatcttccg agttgtggat ccaaatgggc tcgccagact ctggggaaat cacaagaacc    960

gggtgaacat gacctacgag aagatgtctc gtgccctgcg ccactattat aagcttaata   1020

tcattaagaa ggaaccgggg cagaaactcc tgttcagatt tctaaagact ccgggaaaga   1080

tggtccagga caagcacagc cacctggagc cgctggagag ccaggagcag gacagaatag   1140

agttcaagga caagaggcca gaaatctctc cgtgaggggc aggtggactc caggcacccg   1200

gtaccgatgg ggcagggacc gagtctccca tgaaggcaga ctcctcctcc cagcagagca   1260

gcaggatccc cagccagact ctgtacccac aggattacag ccattgcttg ggaaggctgg   1320

gaggcctccc atccaggaca ctgggggcag gagtgtcatc ttttgggcag ggcaatcctg   1380

gggctaaatg aggtacaggg gaatggactc tcccctactg cacccctggg agaggaagcc   1440

aggcaccgat agagcaccca gccccacccc tgtaaatgga atttaccaga tgaagggaat   1500

gaagtccctc actgagcctc agatttcctc acctgtgaaa tgggctgagg caggaaatgg   1560

gaaaaagtgt tagtgcttcc aggcggcact gacagcctca gtaacaataa aaacaatggt   1620

agctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa              1670


<210>  736
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  736

Met Gln Glu Gly Glu Leu Ala Ile Ser Pro Ile Ser Pro Val Ala Ala 
1               5                   10                  15      


Met Pro Pro Leu Gly Thr His Val Gln Ala Arg Cys Glu Ala Gln Ile 
            20                  25                  30          


Asn Leu Leu Gly Glu Gly Gly Ile Cys Lys Leu Pro Gly Arg Leu Arg 
        35                  40                  45              


Ile Gln Pro Ala Leu Trp Ser Arg Glu Asp Val Leu His Trp Leu Arg 
    50                  55                  60                  


Trp Ala Glu Gln Glu Tyr Ser Leu Pro Cys Thr Ala Glu His Gly Phe 
65                  70                  75                  80  


Glu Met Asn Gly Arg Ala Leu Cys Ile Leu Thr Lys Asp Asp Phe Arg 
                85                  90                  95      


His Arg Ala Pro Ser Ser Gly Asp Val Leu Tyr Glu Leu Leu Gln Tyr 
            100                 105                 110         


Ile Lys Thr Gln Arg Arg Ala Leu Val Cys Gly Pro Phe Phe Gly Gly 
        115                 120                 125             


Ile Phe Arg Leu Lys Thr Pro Thr Gln His Ser Pro Val Pro Pro Glu 
    130                 135                 140                 


Glu Val Thr Gly Pro Ser Gln Met Asp Thr Arg Arg Gly His Leu Leu 
145                 150                 155                 160 


Gln Pro Pro Asp Pro Gly Leu Thr Ser Asn Phe Gly His Leu Asp Asp 
                165                 170                 175     


Pro Gly Leu Ala Arg Trp Thr Pro Gly Lys Glu Glu Ser Leu Asn Leu 
            180                 185                 190         


Cys His Cys Ala Glu Leu Gly Cys Arg Thr Gln Gly Val Cys Ser Phe 
        195                 200                 205             


Pro Ala Met Pro Gln Ala Pro Ile Asp Gly Arg Ile Ala Asp Cys Arg 
    210                 215                 220                 


Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Leu Asp Thr Arg Tyr Glu 
225                 230                 235                 240 


Pro Tyr Ile Lys Trp Glu Asp Lys Asp Ala Lys Ile Phe Arg Val Val 
                245                 250                 255     


Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys Asn Arg Val 
            260                 265                 270         


Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His Tyr Tyr Lys 
        275                 280                 285             


Leu Asn Ile Ile Lys Lys Glu Pro Gly Gln Lys Leu Leu Phe Arg Phe 
    290                 295                 300                 


Leu Lys Thr Pro Gly Lys Met Val Gln Asp Lys His Ser His Leu Glu 
305                 310                 315                 320 


Pro Leu Glu Ser Gln Glu Gln Asp Arg Ile Glu Phe Lys Asp Lys Arg 
                325                 330                 335     


Pro Glu Ile Ser Pro 
            340     


<210>  737
<211>  1405
<212>  DNA
<213>  Homosapiens

<400>  737
caccaggagg aaataattca caagttggcc atgcagctga gacacattgg ggacaacatt     60

gatcatagga tggttcgaga ggatcttcaa caggatggca gagatgcact agatcatttt    120

gtcttctttt tctttagaag agttcaggtg ttgctgcatt ttttctggaa caaccatttg    180

ctgtaaaagg aaagtaaagg tcaagtggtc aagttctgtt ttctttttac cctctgagaa    240

acatgaatcc cactgggaca gatgggaaga acacccttct ccgtctccct ctttttgtac    300

ccatcactgt tggtctacac ccagtttgtt gaagaactgc gggttcacga gccatttgtc    360

tcttcggagg agctagctat gagatgtctg cgatcacatc acggtaaagc ccaaggagta    420

attaggaccc caggaagcct tgctgcccag aaaacaccag cgctgtggat ggtcccaggg    480

ctccttgtga ggaaaccttg aacatttcct tccaggaatg aaagagaacc tcgtcctcaa    540

actaaaggcc acagaaatgg gcactacctc ctggcccact ccctgggcac catgccctct    600

ggtgacctgt tggctccact cttgtcactc atgtccagat ctgcagtgcc agcttctcct    660

tctcggtgac atgtcacctc cctgccccaa tcctggctcc aaccctctct ggaaaatcga    720

agtgaaacat ttgtctctaa tactcaaatt caacatatgg ctcatctcat ctaccttccc    780

atttccatgc ctagaggccc cactactacc actagcaccg ttgggtgttt ccttctcagg    840

ctctgattct acaacattta cgttcttttc tcacctttga tcccctcact cctctgtgac    900

ccccttcaag tcttccttca ccactccagt gttttcccat accactcgac cctgctcgaa    960

ggtatctttc cctgctctgt catcctcttt taggcatgcc tgcttaaaat cgggagtgct   1020

tagtccttgg ccaacagtcc tgccttctag aagaatgtaa gacctgaaag agttatgaat   1080

ctatcactag gcaaaaactt ctcttttcct attgctggat ggttttgcta ttattggttg   1140

gtgggccctt tgcctgtgga atgtatttca ctcattctct cctgcacgct gttaggcagt   1200

tctttcacct gcatgcttct tcttttacct ttttgtctac ctcatagtcc ctctctcccc   1260

tcctttaaaa gaattataaa tattaggaaa gcttgttgtt ataaattaaa agtttacata   1320

tgtatcttga gttcttcata ggggaagtgt tattttaaaa aattctaaaa atgaaataaa   1380

tattgttatt ttattgagca tgaaa                                         1405


<210>  738
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  738

Met Gln Leu Arg His Ile Gly Asp Asn Ile Asp His Arg Met Val Arg 
1               5                   10                  15      


Glu Asp Leu Gln Gln Asp Gly Arg Asp Ala Leu Asp His Phe Val Phe 
            20                  25                  30          


Phe Phe Phe Arg Arg Val Gln Val Leu Leu His Phe Phe Trp Asn Asn 
        35                  40                  45              


His Leu Leu 
    50      


<210>  739
<211>  5032
<212>  DNA
<213>  Homosapiens

<400>  739
taacttttcc gtctgcaacc tttaataatt gagagggtat gcgcaactca gaaaagtgcg     60

cccgctgagg ttgggtgcag agtggactgg aggaaaggcg acacccattt acggtgcggc    120

cccggacggg gtccccagac acggccttcc cggcgtgcca cgcgcggagg ggactcttaa    180

cgtgaagcgc tgggtgactc agccgcgtgg ccgcgcggtc cggggcgggg ggcgcgcgcc    240

gctgcggcac agccggtccc ggctgcggct tctggctgcg cggcctgcgc gcgcctcccg    300

ggcggattcc agccccgagc gggacagcgc ggcggggagc gacgagattt ctctctgatc    360

aaacggacag ttcaggactc agaatctaag gatgaatgtt caccgtggca gtgacagtga    420

caggttattg cggcaggagg ccagctgctt agtggatgat actttagctg tagcccaaga    480

aaaagaagca aacagcctgg cttcatctgg tcctcataat cttacttatc ctctaggtcc    540

caggaatgaa gacctctcac ttgactatgc ctctcagcca gcaaatcttc agttccctca    600

cataatgccc cttgctgaag acatcaaagg ttcttgcttc caaagtggga ataaacggaa    660

ccatgaacct tttattgctc cagaaagatt tggaaacagt agtgtgggct ttggcagtaa    720

ttcccattcc caagcaccag agaaagtgac gcttcttgta gatggcacac gttttgttgt    780

gaatccacag attttcactg ctcatccgga taccatgctg ggaaggatgt ttggaccagg    840

aagagagtac aacttcactc ggcccaatga gaagggagag tatgagattg ctgaaggcat    900

cagtgcaact gtatttcgca cagtgctgga ttattacaaa accggtatca tcaattgtcc    960

tgatggcatc tctatcccag atcttagaga tacttgtgat tatctctgca ttaattttga   1020

cttcaacact atccgatgtc aagatctgag tgctttactc catgaactgt ctaatgacgg   1080

tgctcataag cagtttgatc actacctcga agagctcatc ttgcccatca tggtgggctg   1140

tgccaagaaa ggagaacgag agtgccacat tgttgtgctg acggatgagg attctgtgga   1200

ctgggatgaa gaccaccctc caccaatggg ggaggaatat tcccaaattc tttatagctc   1260

caagctctac agattcttca aatatattga gaatagggat gttgcaaaaa cagtgttaaa   1320

ggaacggggc ctaaaaaaca ttcgcattgg aattgaaggt taccctacct gtaaagaaaa   1380

aattaagaga aggcctggcg gccggtctga agtcatctat aattatgtac aacgcccctt   1440

catccagatg tcatgggaaa aggaagaagg gaagagtcgc catgtggatt tccagtgtgt   1500

tcgaagcaaa tccctcacga atctggtagc tgctggagat gatgtcttgg aggaccagga   1560

gatattaatg catcacccac cccaagtgga tgaacttgac cggctaaatg ccccactttc   1620

tcagatggct tctaacgact ttcaggatta gggccagctg tgggtctact ccttgttgga   1680

gcccatctca cctgggatgc ctgcagccag ccctccctcg tgatttgtct caccttgagt   1740

aggagacatg cttctcccct aaccttttcc tttctgccat aattaacata tgtccttttc   1800

agtaagtcca tgcctctggc aggggatgaa gaagtactca ctggtaatta gctaccatct   1860

ttgcagcagc cctggtaact tgaaaaattt gggtctggtg ctgttcattg agtctttgtg   1920

taactgcaaa agcaggaaag gaagtcaaga ctcctgttgc ctcgtgctta gcaaagcagt   1980

ccttatcctt tatactctgt tcttgggttt tgtttttgtc ttgttttata ccaggcaaat   2040

tgcttagtag caaagggacc aaactgaaaa ggtgacaatc tctaacttct aaaagcagac   2100

accaatcgga tgctcattag aggttaatga agatgccatt cttggtggcc tctgcaccca   2160

aattgcatct ggaaagaact agggtctcat tcagaatgtc caaaaggaaa ttcttaagag   2220

cttaaattca gatttgtgtc tcattaatgc agtgaacaat tcaaaaccac acagattcct   2280

tggcaggaag gataatggaa taacagtgtt gatgagacct ttttagcttc aaggtttcgg   2340

agtctaaaca aatggatgat tcatttggaa tgaaactcac aatgcaagta gaaggacctc   2400

tccaaatcag gccagttggg ttatcctggc ttggaatctg gtgtgaaacc ataggtctta   2460

acactctgga gcagcacatt gctgtggata tgtccaggag accttagata tggcttaaag   2520

gctttcaaga tgaggacaga aattgcttac aattgctcag tttctcaaca gaaagactca   2580

taagagtgcc agcatggggt acatggagtg aagctgggtg ggaagcatca tctgcacagt   2640

ccctgtccta gtgcaggact tttctctgta tgttttcata ccatgggatt tttggatatc   2700

agtgtatttt ggttcttgaa atagcctaat agctgctcac acattgggta ggaatattat   2760

accaatgtca tccccaaagg aagggtgagc tgaatggaaa ttaagcccag tcattttatt   2820

tgatctatta gctctgttat cagtgcatga tcacccagat caccctcctc agcccacaca   2880

gtgctgaacc atcttccctc ctgttctcca tggctattaa tagtatagct aaatttagag   2940

tgcagagcca gatataagta ttttggaatt atctcccagc ttgtggtaga agctgactgg   3000

aatacaggtt gagtatctct tatccaaaat gctagggacc agaaaggttt cagatttttt   3060

cagattttgg aatacttaac agttgagcac cccaaatctg aaaggcttct gaacgtcatg   3120

tcagcactca aaaaagtgga ttttggagca cttcaaattt cggatttttg gatttgggat   3180

gctcatcctg tgtaggagag gctactcgat tccatttaat gactgtccta gtcataatca   3240

tccaaagata aaagccaggt agatgttgaa agctctttcc agggctgaaa aagtgttctt   3300

acgttctctg catgtgacta gcatcactgt ggaaattaat gctctgttct tcactagaat   3360

gtagtaagtg gttaaactga gctatccccc acctgatgac tattggcatc catttgcaag   3420

gccaatggcc tggattaagg gttaggatta tttgtagcta gaaggtaatt ttatttctgt   3480

gaaactaatt ggctcatatt tgaggttagg tgtggccttg accttaccag tacatttata   3540

cccactacca gttgactagc ccagataatt gttaaatggt gcttcttttc tgcttctcag   3600

tagacttcca tgccattaca aaggaaattt gaattaccta gtgtttgtat attccatgat   3660

aactatgtat aacttctgtt acacagctta tgtattgtta acatttaagt gtaaaccatg   3720

ccacagctaa cacttaaaaa tgaaaactaa ttagttcttg cttagggaaa atgccaggta   3780

tgaagtatgg catatacttg acactgtcct gtgtaaccct ttactttgct caggctttca   3840

agattgagtc ttttttcccc caaattaggt taacatgcat ttgaccccaa cctgtggggt   3900

ttgagtaagc tggaaatctg tgacggtagg ctttctagtg tcacgaggtg gtggtgactg   3960

aaggaaaagc tgggatcaca ggttccttct gatggagagg aaggtttatt tctatgcccc   4020

tcccaccacc ctccacctag agctcaccca agcctgctcc agtcccaggg gcaggccatt   4080

ctgcaaaagc aggacctcac agaaacaagg gctgggttga ggtcaccccc ttcagagttg   4140

gttcctggcc agatgggtaa gaggcatttg taattttaaa aatgtgaaac ttgggtttgg   4200

tgttttcttc taagtgccta aataagcaag ccaggctgtt gatattttag ccagagaaat   4260

cggcaagcca agattaaccc gaatctgaag tttagaatct tgagtttgca tctgcatcat   4320

atcatgctgt tttgatgagg aaacatttgc cactgaggag ttggagggag ggcaagacga   4380

cagtgttaag tcagatcatt taatggtttc ccctaagccc tggaaaaata tttgaaagaa   4440

tggcagcaaa aaggttaaga aagcaagcca gatttactgc acaatatgca gtacccagta   4500

ctactttaaa tcccaagaga acagtgtgat gtctaatata tacaggtcta tgaaaatact   4560

gtggaataag cccaggaagg ttagatgtgt ttgcaaataa gttgcccaaa gggtccccct   4620

ctaagtaaaa caaatattca gaccacaggc tttaatgtaa actgtcaaaa agtgggatgt   4680

ggaggatttt tgttaagtgt caatcgaagt taaaaagcaa gggtttttgg ccaggcgtgg   4740

tggctcacgc ctgtaatccc agcactttgg gaggccgagg ccggcaaatc acctaaggtc   4800

aggagttcga gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa   4860

aaattagccc ggtgtggtgg caagtgcctg tagtcccagc tacttgggag gctgaggcag   4920

gagaactgct tgaacccggg aggtagaggt tgcagtgagc cacgatcatg ccactgcact   4980

ccagcctggg caacagagca agactccatc tcaaaaaaaa aaaaaaaaaa aa           5032


<210>  740
<211>  419
<212>  PRT
<213>  Homosapiens

<400>  740

Met Asn Val His Arg Gly Ser Asp Ser Asp Arg Leu Leu Arg Gln Glu 
1               5                   10                  15      


Ala Ser Cys Leu Val Asp Asp Thr Leu Ala Val Ala Gln Glu Lys Glu 
            20                  25                  30          


Ala Asn Ser Leu Ala Ser Ser Gly Pro His Asn Leu Thr Tyr Pro Leu 
        35                  40                  45              


Gly Pro Arg Asn Glu Asp Leu Ser Leu Asp Tyr Ala Ser Gln Pro Ala 
    50                  55                  60                  


Asn Leu Gln Phe Pro His Ile Met Pro Leu Ala Glu Asp Ile Lys Gly 
65                  70                  75                  80  


Ser Cys Phe Gln Ser Gly Asn Lys Arg Asn His Glu Pro Phe Ile Ala 
                85                  90                  95      


Pro Glu Arg Phe Gly Asn Ser Ser Val Gly Phe Gly Ser Asn Ser His 
            100                 105                 110         


Ser Gln Ala Pro Glu Lys Val Thr Leu Leu Val Asp Gly Thr Arg Phe 
        115                 120                 125             


Val Val Asn Pro Gln Ile Phe Thr Ala His Pro Asp Thr Met Leu Gly 
    130                 135                 140                 


Arg Met Phe Gly Pro Gly Arg Glu Tyr Asn Phe Thr Arg Pro Asn Glu 
145                 150                 155                 160 


Lys Gly Glu Tyr Glu Ile Ala Glu Gly Ile Ser Ala Thr Val Phe Arg 
                165                 170                 175     


Thr Val Leu Asp Tyr Tyr Lys Thr Gly Ile Ile Asn Cys Pro Asp Gly 
            180                 185                 190         


Ile Ser Ile Pro Asp Leu Arg Asp Thr Cys Asp Tyr Leu Cys Ile Asn 
        195                 200                 205             


Phe Asp Phe Asn Thr Ile Arg Cys Gln Asp Leu Ser Ala Leu Leu His 
    210                 215                 220                 


Glu Leu Ser Asn Asp Gly Ala His Lys Gln Phe Asp His Tyr Leu Glu 
225                 230                 235                 240 


Glu Leu Ile Leu Pro Ile Met Val Gly Cys Ala Lys Lys Gly Glu Arg 
                245                 250                 255     


Glu Cys His Ile Val Val Leu Thr Asp Glu Asp Ser Val Asp Trp Asp 
            260                 265                 270         


Glu Asp His Pro Pro Pro Met Gly Glu Glu Tyr Ser Gln Ile Leu Tyr 
        275                 280                 285             


Ser Ser Lys Leu Tyr Arg Phe Phe Lys Tyr Ile Glu Asn Arg Asp Val 
    290                 295                 300                 


Ala Lys Thr Val Leu Lys Glu Arg Gly Leu Lys Asn Ile Arg Ile Gly 
305                 310                 315                 320 


Ile Glu Gly Tyr Pro Thr Cys Lys Glu Lys Ile Lys Arg Arg Pro Gly 
                325                 330                 335     


Gly Arg Ser Glu Val Ile Tyr Asn Tyr Val Gln Arg Pro Phe Ile Gln 
            340                 345                 350         


Met Ser Trp Glu Lys Glu Glu Gly Lys Ser Arg His Val Asp Phe Gln 
        355                 360                 365             


Cys Val Arg Ser Lys Ser Leu Thr Asn Leu Val Ala Ala Gly Asp Asp 
    370                 375                 380                 


Val Leu Glu Asp Gln Glu Ile Leu Met His His Pro Pro Gln Val Asp 
385                 390                 395                 400 


Glu Leu Asp Arg Leu Asn Ala Pro Leu Ser Gln Met Ala Ser Asn Asp 
                405                 410                 415     


Phe Gln Asp 
            


<210>  741
<211>  3593
<212>  DNA
<213>  Homosapiens

<400>  741
ctcggccccg ggctgccgcg ccagcccgtc tccgcggcgg gggaccgggc tgccttggcc     60

cctcagcgct cgcgtctttt ccggcagttg gaacgcttcc tgttgtcctc acccgtaacc    120

gcctgttgcc ccctgtctca gagtccctca cgcgtcccct cccgtctttg gctcgttggc    180

tgccgccgcc ggggcttcgc cagccttcaa gtcgagacta ctggccgaag gggcgtctgc    240

ggctctccgc cgtccccagc cctgcctctc cctgggctct gcagccatgg caatgacagg    300

ctcaacacct tgctcatcca tgagtaacca cacaaaggaa agggtgacaa tgaccaaagt    360

gacactggag aatttttata gcaaccttat cgctcaacat gaagaacgag aaatgagaca    420

aaagaagtta gaaaaggtga tggaagaaga aggcctaaaa gatgaggaga aacgactccg    480

gagatcagca catgctcgga aggaaacaga gtttcttcgt ttgaagagaa caagacttgg    540

attggaagat tttgagtcct taaaagtaat aggcagagga gcatttggtg aggtacggct    600

tgttcagaag aaagatacgg gacatgtgta tgcaatgaaa atactccgta aagcagatat    660

gcttgaaaaa gagcaggttg gccacattcg tgcggagcgt gacattctag tggaggcaga    720

cagtttgtgg gttgtgaaaa tgttctatag ttttcaggat aagctaaacc tctacctaat    780

catggagttc ctgcctggag gggacatgat gaccttgttg atgaaaaaag acactctgac    840

agaagaggag actcagtttt atatagcaga aacagtatta gccatagact ctattcacca    900

acttggattc atccacagag acatcaaacc agacaacctt cttttggaca gcaagggcca    960

tgtgaaactt tctgactttg gtctttgcac aggactgaaa aaagcacata ggacagaatt   1020

ttataggaat ctgaaccaca gcctccccag tgatttcact ttccagaaca tgaattccaa   1080

aaggaaagca gaaacctgga aaagaaatag acgtcagcta gccttctcca cagtaggcac   1140

tcctgactac attgctcctg aggtgttcat gcagaccggg tacaacaagc tctgtgattg   1200

gtggtcgctt ggggtgatca tgtatgagat gctcatcggc tacccacctt tctgttctga   1260

gacccctcaa gagacatata agaaggtgat gaactggaaa gaaactttga cttttcctcc   1320

agaagttccc atctctgaga aagccaagga tctaattttg aggttctgct gtgaatggga   1380

acatagaatt ggagctcctg gagttgagga aataaaaagt aactcttttt ttgaaggcgt   1440

tgactgggaa catatcagag agagacctgc tgcaatatct attgaaatca aaagcattga   1500

tgatacctca aacttcgatg agtttccaga atctgatatt cttaagccaa cagtggccac   1560

aagtaatcat cctgagactg actacaagaa caaagactgg gtcttcatca attacacgta   1620

caagcgcttt gagggcctga ctgcaagggg ggcaatacct tcctacatga aagcagcaaa   1680

atagtactct tgccacggaa tcctatgtgg agcagagttc tttgtataac atcatgcttt   1740

tcctctcaca ctcttgaaga gcttccaaga agttgatgga acccaccaat atgtcatagt   1800

aaagtctcct gaaatgtggt agtaagagga ttttcttcca taatgcatct gaaaaactgt   1860

aaacaaagac aaccatttct actacgtcgg ccataaacag ctatcctgct ttggaagaga   1920

agcatcatga gccaatttga taggtgtttt aaaaataact tgagttttcc taagttcatc   1980

agaatgaagg ggaaaaacag ccatcatcca acattattga gattgtcgtg tatagtcatc   2040

gaatatcagc cagttcctgt aattttgtga cacgctctct gccaagccca ccaagtattt   2100

cctttatagc taaaagttcc atagtactaa ggaaataaag caataaagac agtctcagca   2160

gccaggattc tggctgaagg aaatgatccg ccaccctgag ggtggtgatg gtagtttcta   2220

cccatacctc agcctcaggc gagtggctta tagcctccat tcatggtgca ctttatttat   2280

ggtactaaga taaagactgt caatccattg atttatctcc tcctgtcccc catctaaaat   2340

acccatgctg cttttctgag tgttgatggg ggttaccagc ttgatccact gttgctctta   2400

gaaggcccag aaagtctttg ggcattgcca agaaatcccg gattatgtgg aaaaccctca   2460

ctttctcttc acggctgtac cagaaaatcc ctaagacaga tcttgccgtg gactagcaat   2520

acctgcaagt gctgccaatg ggaactcaat ttattcctgg gaacctaacg aggagagccc   2580

aggcctaggc aggaggcctg gaaccctctt ggctaaggtg ctgttcctgt tcctgcaagg   2640

tctccagaac ccctttggaa atggtgaagg aaccagccca atagaagtac agagccagct   2700

gacaagtcct tgtaaagctc actcctcagt ccttggcaca gccatgtttt gtcttctctc   2760

ttggtatttc ttctctccca actttagcca ttttgccttg gaatcatgat tacaattttt   2820

tcctttgcag atgccttcct gggggatact cctccccacc ctaaagggtc gcctgcaact   2880

taggcggatt gggtctctct gctgtggcgt tctctcttga gagaccctct gaattttagc   2940

acaaagtgcc ttctgtttca cagctgccac cacctttaga ggaatttcgt cagaaaaatg   3000

tggaggctcc atattaatgc attatttttt aaaaagtttt gataactctt aaagcatcat   3060

ttgcacctat gtgggaactt tgcctgttgc aaagtattgt ggccgagctg cagctgggag   3120

cctgctttct gccagtcttg aggttctgaa gatcagcttt gaaaggaaag tatgtcctag   3180

cttagccatt cagaagagaa aaatggaata tcagagttac agttgtcagt gaaactactt   3240

tggattttaa cctcttagag gaagaaaaaa ggttagggaa gtgtcaactc tggatgaagg   3300

tgatgtgttt gcctctcagt ctttcattca tagcctgcta gtgaaaagga agtaaatgag   3360

attcttttgt gtgactttgt agtctctttg tattaccaaa tagttggggt gttgactcct   3420

gtgtgttttg caagaatgtg tggtaagcct gggtaaagag aaggaactgc ggtgttggga   3480

gagtctttgt gttggggagt ggcaggggat gatttgtttc aggggaaaat gcccacattt   3540

taacttttaa acttctgaat aaactgtgta aaaacaaaaa aaaaaaaaaa aaa          3593


<210>  742
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  742

Met Ala Met Thr Gly Ser Thr Pro Cys Ser Ser Met Ser Asn His Thr 
1               5                   10                  15      


Lys Glu Arg Val Thr Met Thr Lys Val Thr Leu Glu Asn Phe Tyr Ser 
            20                  25                  30          


Asn Leu Ile Ala Gln His Glu Glu Arg Glu Met Arg Gln Lys Lys Leu 
        35                  40                  45              


Glu Lys Val Met Glu Glu Glu Gly Leu Lys Asp Glu Glu Lys Arg Leu 
    50                  55                  60                  


Arg Arg Ser Ala His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Thr Arg Leu Gly Leu Glu Asp Phe Glu Ser Leu Lys Val Ile Gly 
                85                  90                  95      


Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr Gly 
            100                 105                 110         


His Val Tyr Ala Met Lys Ile Leu Arg Lys Ala Asp Met Leu Glu Lys 
        115                 120                 125             


Glu Gln Val Gly His Ile Arg Ala Glu Arg Asp Ile Leu Val Glu Ala 
    130                 135                 140                 


Asp Ser Leu Trp Val Val Lys Met Phe Tyr Ser Phe Gln Asp Lys Leu 
145                 150                 155                 160 


Asn Leu Tyr Leu Ile Met Glu Phe Leu Pro Gly Gly Asp Met Met Thr 
                165                 170                 175     


Leu Leu Met Lys Lys Asp Thr Leu Thr Glu Glu Glu Thr Gln Phe Tyr 
            180                 185                 190         


Ile Ala Glu Thr Val Leu Ala Ile Asp Ser Ile His Gln Leu Gly Phe 
        195                 200                 205             


Ile His Arg Asp Ile Lys Pro Asp Asn Leu Leu Leu Asp Ser Lys Gly 
    210                 215                 220                 


His Val Lys Leu Ser Asp Phe Gly Leu Cys Thr Gly Leu Lys Lys Ala 
225                 230                 235                 240 


His Arg Thr Glu Phe Tyr Arg Asn Leu Asn His Ser Leu Pro Ser Asp 
                245                 250                 255     


Phe Thr Phe Gln Asn Met Asn Ser Lys Arg Lys Ala Glu Thr Trp Lys 
            260                 265                 270         


Arg Asn Arg Arg Gln Leu Ala Phe Ser Thr Val Gly Thr Pro Asp Tyr 
        275                 280                 285             


Ile Ala Pro Glu Val Phe Met Gln Thr Gly Tyr Asn Lys Leu Cys Asp 
    290                 295                 300                 


Trp Trp Ser Leu Gly Val Ile Met Tyr Glu Met Leu Ile Gly Tyr Pro 
305                 310                 315                 320 


Pro Phe Cys Ser Glu Thr Pro Gln Glu Thr Tyr Lys Lys Val Met Asn 
                325                 330                 335     


Trp Lys Glu Thr Leu Thr Phe Pro Pro Glu Val Pro Ile Ser Glu Lys 
            340                 345                 350         


Ala Lys Asp Leu Ile Leu Arg Phe Cys Cys Glu Trp Glu His Arg Ile 
        355                 360                 365             


Gly Ala Pro Gly Val Glu Glu Ile Lys Ser Asn Ser Phe Phe Glu Gly 
    370                 375                 380                 


Val Asp Trp Glu His Ile Arg Glu Arg Pro Ala Ala Ile Ser Ile Glu 
385                 390                 395                 400 


Ile Lys Ser Ile Asp Asp Thr Ser Asn Phe Asp Glu Phe Pro Glu Ser 
                405                 410                 415     


Asp Ile Leu Lys Pro Thr Val Ala Thr Ser Asn His Pro Glu Thr Asp 
            420                 425                 430         


Tyr Lys Asn Lys Asp Trp Val Phe Ile Asn Tyr Thr Tyr Lys Arg Phe 
        435                 440                 445             


Glu Gly Leu Thr Ala Arg Gly Ala Ile Pro Ser Tyr Met Lys Ala Ala 
    450                 455                 460                 


Lys 
465 


<210>  743
<211>  2060
<212>  DNA
<213>  Homosapiens

<400>  743
gagagagttg gttggtgttg ggccggagga aagcgggaag actcatcgga gcgtgtggat     60

ttgagccgcc gcatttttta accctagatc tcgaaatgca tcgtgattcc tgtccattgg    120

actgtaaggt ttatgtaggc aatcttggaa acaatggcaa caagacggaa ttggaacggg    180

cttttggcta ctatggacca ctccgaagtg tgtgggttgc tagaaaccca cccggctttg    240

cttttgttga atttgaagat ccccgagatg cagctgatgc agtccgagag ctagatggaa    300

gaacactatg tggctgccgt gtaagagtgg aactgtcgaa tggtgaaaaa agaagtagaa    360

atcgtggccc acctccctct tggggtcgtc gccctcgaga tgattatcgt aggaggagtc    420

ctccacctcg tcgcagatct ccaagaagga gaagcttctc tcgcagccgg agcaggtccc    480

tttctagaga taggagaaga gagagatcgc tgtctcggga gagaaatcac aagccgtccc    540

gatccttctc taggtctcgt agtcgatcta ggtcaaatga aaggaaatag aagacagttt    600

gcaagagaag tggtgtacag gaaattactt catttgacag gagtatgtac agaaaattca    660

agttttgttt gagacttcat aagcttggtg catttttaag atgttttagc tgttcaaatc    720

tgtttgtctc ttgaaacagt gacacaaagg tgtaattctc tatggtttga aatggatcat    780

acgaggcatg taataccaag aattgttact ttacaatgtt cccttaagca aaattgaatt    840

tgctttgaac ttttagttat gcacagactg ataataaacc tctaaacctg cccagcggaa    900

gtgtgttttt ttttaaattt aaatacagaa acaactggca aaaatgaact aagatttact    960

tttttttcca tagctgggat ataggctgca gctatagttg aacaagcagt ctttaaaaac   1020

tgctgtgaaa cacaggccat cagggaaaac gaaatgctgc actattaaat tagaggtttt   1080

tgaaaaatcc aactctcatc ctgggcagag gttgcctagt tggtatagaa tgttaagttt   1140

caagaaagtt tacctttgct ttaggtcata agttccttat ttgattgctg tatatggata   1200

catggctgtt cgtgacattc tttatgtgca aatttgtgat ttcaaaaatg tcctgccagt   1260

ttaagggtac attgtagagc cgaactttga gttactgtgc aagatttttt tttcatgctg   1320

tcatttgtaa tatgttttgt gagaatcctt gggattaaag ttttggttac aaattgttct   1380

ttaacttgaa agcctgtttt tccttgcaaa ctcaaatctg tgagcttggt accaagtcca   1440

ggtataacat tcctattgga agccatactt atattttctt gtaaagtgct tttgaattaa   1500

taaaatatta gcataattgt gtatagtcag ttgaacccac tgttaccatt gttcttatcc   1560

catgggaagc agttggttac acgattctta ttttataaga aacagctgag aggcactatg   1620

gattagtctt ctgaagtgaa ggaaatatag atgtcaccta agtgatagtt aacccatttt   1680

tttttttttt aggcatagaa gccagttcag ggtccataat atttagtgac caacatttta   1740

aagtatagca gcaacctggt tcttaaacac aaagtaagtt gcccattaac aaatggcttt   1800

tatctttagc atgaaaactt tccacaggtc taaaaattgc ttccatttta taatttgagg   1860

tgttgcatgg gaattctaag ctgatccatc atgatgtaaa agttcacaat atggttcaaa   1920

tgtaacagtg cagaattgaa tatggaggca tgcataacct tcctcttaga aaatggcagg   1980

tgttgtaatt tcaaattttt gtgcaattag attaaatcat aatgcaacag tcaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa                                               2060


<210>  744
<211>  164
<212>  PRT
<213>  Homosapiens

<400>  744

Met His Arg Asp Ser Cys Pro Leu Asp Cys Lys Val Tyr Val Gly Asn 
1               5                   10                  15      


Leu Gly Asn Asn Gly Asn Lys Thr Glu Leu Glu Arg Ala Phe Gly Tyr 
            20                  25                  30          


Tyr Gly Pro Leu Arg Ser Val Trp Val Ala Arg Asn Pro Pro Gly Phe 
        35                  40                  45              


Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Ala Asp Ala Val Arg 
    50                  55                  60                  


Glu Leu Asp Gly Arg Thr Leu Cys Gly Cys Arg Val Arg Val Glu Leu 
65                  70                  75                  80  


Ser Asn Gly Glu Lys Arg Ser Arg Asn Arg Gly Pro Pro Pro Ser Trp 
                85                  90                  95      


Gly Arg Arg Pro Arg Asp Asp Tyr Arg Arg Arg Ser Pro Pro Pro Arg 
            100                 105                 110         


Arg Arg Ser Pro Arg Arg Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser 
        115                 120                 125             


Leu Ser Arg Asp Arg Arg Arg Glu Arg Ser Leu Ser Arg Glu Arg Asn 
    130                 135                 140                 


His Lys Pro Ser Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser Arg Ser 
145                 150                 155                 160 


Asn Glu Arg Lys 
                


<210>  745
<211>  2446
<212>  DNA
<213>  Homosapiens

<400>  745
ggccgggcgg gcatgggcct tcccggcccg gagctgggag tcgaaggggc gggaggcgtg     60

atggtgaact cgcaagaagt ttgagggacg cgcgggcccc gcgcccactc cccctccacc    120

ggacacggct ggggccggcg atgcctgaga gggggtcgga ggacgcagtg aacatatatg    180

catgtacagt gtggatcctc atctgagagg agggagatga aaacacaccc acctcacagg    240

ctgttgtgag gactaagggt gcggcagtgc ctggtacatg ggagccagcg ccggcagcca    300

ccatggcgtc acgcataggg ttgcgcatgc agctcatgcg ggagcaggcg cagcaggagg    360

agcagcggga gcgcatgcag caacaggctg tcatgcatta catgcagcag cagcagcagc    420

agcaacagca gcagctcgga gggccgccca ccccggccat caataccccc gtccacttcc    480

agtcgccacc acctgtgcct ggggaggtgt tgaaggtgca gtcctacctg gagaatccca    540

catcctacca tctgcagcag tcgcagcatc agaaggtgcg ggagtacctg tccgagacct    600

atgggaacaa gtttgctgcc cacatcagcc cagcccaggg ctctccgaaa cccccaccag    660

ccgcctcccc aggggtgcga gctggacacg tgctgtcctc ctccgctggc aacagtgctc    720

ccaatagccc catggccatg ctgcacattg gctccaaccc tgagagggag ttggatgatg    780

tcattgacaa cattatgcgt ctggacgatg tccttggcta catcaatcct gaaatgcaga    840

tgcccaacac gctacccctg tccagcagcc acctgaatgt gtacagcagc gacccccagg    900

tcacagcctc cctggtgggc gtcaccagca gctcctgccc tgcggacctg acccagaagc    960

gagagctcac agatgctgag agcagggccc tggccaagga gcggcagaag aaagacaatc   1020

acaacttaat tgaaaggaga cgaaggttca acatcaatga ccgcatcaag gagttgggaa   1080

tgctgatccc caaggccaat gacctggacg tgcgctggaa caagggcacc atcctcaagg   1140

cctctgtgga ttacatccgg aggatgcaga aggacctgca aaagtccagg gagctggaga   1200

accactctcg ccgcctggag atgaccaaca agcagctctg gctccgtatc caggagctgg   1260

agatgcaggc tcgagtgcac ggcctcccta ccacctcccc gtccggcatg aacatggctg   1320

agctggccca gcaggtggtg aagcaggagc tgcctagcga agagggccca ggggaggccc   1380

tgatgctggg ggctgaggtc cctgaccctg agccactgcc agctctgccc ccgcaagccc   1440

cgctgcccct gcccacccag ccaccatccc cattccatca cctggacttc agccacagcc   1500

tgagctttgg gggcagggag gacgagggtc ccccgggcta ccccgaaccc ctggcgccgg   1560

ggcatggctc cccattcccc agcctgtcca agaaggatct ggacctcatg ctcctggacg   1620

actcactgct accgctggcc tctgatccac ttctgtccac catgtccccc gaggcctcca   1680

aggccagcag ccgccggagc agcttcagca tggaggaggg cgatgtgctg tgaccctggc   1740

tgcccctgtg ccagggaaca ggggccggcc tgggggctgg gagggccagg ggcacctccc   1800

tcccaccctt caggctgcac tgtgtgtgaa gtagccacct gccctgcctc cctcctcccc   1860

gttggcccct gtttggactt agtgcctgtc tggcagcctg tggggtcagg agaagcaccc   1920

ccagggcagc cctcttgact ggcgcagtgg gaagaggcct tcagcccctc tcccggagat   1980

ggaatcgcgg ggcagggagg ggcagggtgt tctagaggtg agaagagggc ctggtggaga   2040

ttccctgtct tctgagcccg agcccctcat taccagtgaa ggacatgctt gaggggttcg   2100

ggaagctcct catctgaggc aactggtcct gggggtgctc aggcctgcct ttttgggact   2160

cagatggcag gaggtccacc ccgcagcctg gtcctcggct ctcccacagg tgggcacccc   2220

ccactttggt gctaatagct ctccaccagg tggtgtgagc gcgggggctg ccagaagcgg   2280

gaggggtcac tgccggaaga gcagctgccc tccgacccct cactttgtgc ctttagtaaa   2340

cactgtgctt tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                  2446


<210>  746
<211>  476
<212>  PRT
<213>  Homosapiens

<400>  746

Met Ala Ser Arg Ile Gly Leu Arg Met Gln Leu Met Arg Glu Gln Ala 
1               5                   10                  15      


Gln Gln Glu Glu Gln Arg Glu Arg Met Gln Gln Gln Ala Val Met His 
            20                  25                  30          


Tyr Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gly Gly Pro 
        35                  40                  45              


Pro Thr Pro Ala Ile Asn Thr Pro Val His Phe Gln Ser Pro Pro Pro 
    50                  55                  60                  


Val Pro Gly Glu Val Leu Lys Val Gln Ser Tyr Leu Glu Asn Pro Thr 
65                  70                  75                  80  


Ser Tyr His Leu Gln Gln Ser Gln His Gln Lys Val Arg Glu Tyr Leu 
                85                  90                  95      


Ser Glu Thr Tyr Gly Asn Lys Phe Ala Ala His Ile Ser Pro Ala Gln 
            100                 105                 110         


Gly Ser Pro Lys Pro Pro Pro Ala Ala Ser Pro Gly Val Arg Ala Gly 
        115                 120                 125             


His Val Leu Ser Ser Ser Ala Gly Asn Ser Ala Pro Asn Ser Pro Met 
    130                 135                 140                 


Ala Met Leu His Ile Gly Ser Asn Pro Glu Arg Glu Leu Asp Asp Val 
145                 150                 155                 160 


Ile Asp Asn Ile Met Arg Leu Asp Asp Val Leu Gly Tyr Ile Asn Pro 
                165                 170                 175     


Glu Met Gln Met Pro Asn Thr Leu Pro Leu Ser Ser Ser His Leu Asn 
            180                 185                 190         


Val Tyr Ser Ser Asp Pro Gln Val Thr Ala Ser Leu Val Gly Val Thr 
        195                 200                 205             


Ser Ser Ser Cys Pro Ala Asp Leu Thr Gln Lys Arg Glu Leu Thr Asp 
    210                 215                 220                 


Ala Glu Ser Arg Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn His 
225                 230                 235                 240 


Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys 
                245                 250                 255     


Glu Leu Gly Met Leu Ile Pro Lys Ala Asn Asp Leu Asp Val Arg Trp 
            260                 265                 270         


Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Arg Met 
        275                 280                 285             


Gln Lys Asp Leu Gln Lys Ser Arg Glu Leu Glu Asn His Ser Arg Arg 
    290                 295                 300                 


Leu Glu Met Thr Asn Lys Gln Leu Trp Leu Arg Ile Gln Glu Leu Glu 
305                 310                 315                 320 


Met Gln Ala Arg Val His Gly Leu Pro Thr Thr Ser Pro Ser Gly Met 
                325                 330                 335     


Asn Met Ala Glu Leu Ala Gln Gln Val Val Lys Gln Glu Leu Pro Ser 
            340                 345                 350         


Glu Glu Gly Pro Gly Glu Ala Leu Met Leu Gly Ala Glu Val Pro Asp 
        355                 360                 365             


Pro Glu Pro Leu Pro Ala Leu Pro Pro Gln Ala Pro Leu Pro Leu Pro 
    370                 375                 380                 


Thr Gln Pro Pro Ser Pro Phe His His Leu Asp Phe Ser His Ser Leu 
385                 390                 395                 400 


Ser Phe Gly Gly Arg Glu Asp Glu Gly Pro Pro Gly Tyr Pro Glu Pro 
                405                 410                 415     


Leu Ala Pro Gly His Gly Ser Pro Phe Pro Ser Leu Ser Lys Lys Asp 
            420                 425                 430         


Leu Asp Leu Met Leu Leu Asp Asp Ser Leu Leu Pro Leu Ala Ser Asp 
        435                 440                 445             


Pro Leu Leu Ser Thr Met Ser Pro Glu Ala Ser Lys Ala Ser Ser Arg 
    450                 455                 460                 


Arg Ser Ser Phe Ser Met Glu Glu Gly Asp Val Leu 
465                 470                 475     


<210>  747
<211>  1366
<212>  DNA
<213>  Homosapiens

<400>  747
cgcagaactc agagctgctc ttcctctgtg gccagttggg gaccagcatc atgaagtgga     60

tggtggtggt cttggtctgc ctccagctct tggaggcagc agtggtcaaa gtgcccctga    120

agaaatttaa gtctatccgt gagaccatga aggagaaggg cttgctgggg gagttcctga    180

ggacccacaa gtatgatcct gcttggaagt accgctttgg tgacctcagc gtgacctacg    240

agcccatggc ctacatggat gctgcctact ttggtgagat cagcatcggg actccacccc    300

agaacttcct ggtccttttt gacaccggct cctccaactt gtgggtgccc tctgtctact    360

gccagagcca ggcctgcacc agtcactccc gcttcaaccc cagcgagtcg tccacctact    420

ccaccaatgg gcagaccttc tccctgcagt atggcagtgg cagcctcacc ggcttctttg    480

gctatgacac cctgactgtc cagagcatcc aggtccccaa ccaggagttc ggcttgagtg    540

agaatgagcc tggtaccaac ttcgtctatg cgcagtttga tggcatcatg ggcctggcct    600

accctgctct gtccgtggat gaggccacca cagctatgca gggcatggtg caggagggcg    660

ccctcaccag ccccgtcttc agcgtctacc tcagcaacca gcagggctcc agcgggggag    720

cggttgtctt tgggggtgtg gatagcagcc tgtacacggg gcagatctac tgggcgcctg    780

tcacccagga actctactgg cagattggca ttgaagagtt cctcatcggc ggccaggcct    840

ccggctggtg ttctgagggt tgccaggcca tcgtggacac aggcacctct ctgctaactg    900

tgccccagca gtacatgagt gctcttctgc aggccacagg ggcccaggag gatgagtatg    960

gacagtttct cgtgaactgt aacagcattc agaatctgcc cagcttgacc ttcatcatca   1020

atggtgtgga gttccctctg ccaccttcct cctatatcct cagtaacaac ggctactgca   1080

ccgtgggagt cgagcccacc tacctgtcct cccagaacgg ccagcccctg tggatcctcg   1140

gggatgtctt cctcaggtcc tactattccg tctacgactt gggcaacaac agagtaggct   1200

ttgccactgc cgcctagact tgctgcctcg acacgtgggc tcccctcttc ctcttgaccc   1260

tgcaccctcc tagggcattg tatctgtctt tccactctgg attcagcctt ctttttctgg   1320

actctggact ttctctaata ataaatagtt cttctaaaaa aaaaaa                  1366


<210>  748
<211>  388
<212>  PRT
<213>  Homosapiens

<400>  748

Met Lys Trp Met Val Val Val Leu Val Cys Leu Gln Leu Leu Glu Ala 
1               5                   10                  15      


Ala Val Val Lys Val Pro Leu Lys Lys Phe Lys Ser Ile Arg Glu Thr 
            20                  25                  30          


Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg Thr His Lys Tyr 
        35                  40                  45              


Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser Val Thr Tyr Glu 
    50                  55                  60                  


Pro Met Ala Tyr Met Asp Ala Ala Tyr Phe Gly Glu Ile Ser Ile Gly 
65                  70                  75                  80  


Thr Pro Pro Gln Asn Phe Leu Val Leu Phe Asp Thr Gly Ser Ser Asn 
                85                  90                  95      


Leu Trp Val Pro Ser Val Tyr Cys Gln Ser Gln Ala Cys Thr Ser His 
            100                 105                 110         


Ser Arg Phe Asn Pro Ser Glu Ser Ser Thr Tyr Ser Thr Asn Gly Gln 
        115                 120                 125             


Thr Phe Ser Leu Gln Tyr Gly Ser Gly Ser Leu Thr Gly Phe Phe Gly 
    130                 135                 140                 


Tyr Asp Thr Leu Thr Val Gln Ser Ile Gln Val Pro Asn Gln Glu Phe 
145                 150                 155                 160 


Gly Leu Ser Glu Asn Glu Pro Gly Thr Asn Phe Val Tyr Ala Gln Phe 
                165                 170                 175     


Asp Gly Ile Met Gly Leu Ala Tyr Pro Ala Leu Ser Val Asp Glu Ala 
            180                 185                 190         


Thr Thr Ala Met Gln Gly Met Val Gln Glu Gly Ala Leu Thr Ser Pro 
        195                 200                 205             


Val Phe Ser Val Tyr Leu Ser Asn Gln Gln Gly Ser Ser Gly Gly Ala 
    210                 215                 220                 


Val Val Phe Gly Gly Val Asp Ser Ser Leu Tyr Thr Gly Gln Ile Tyr 
225                 230                 235                 240 


Trp Ala Pro Val Thr Gln Glu Leu Tyr Trp Gln Ile Gly Ile Glu Glu 
                245                 250                 255     


Phe Leu Ile Gly Gly Gln Ala Ser Gly Trp Cys Ser Glu Gly Cys Gln 
            260                 265                 270         


Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Val Pro Gln Gln Tyr 
        275                 280                 285             


Met Ser Ala Leu Leu Gln Ala Thr Gly Ala Gln Glu Asp Glu Tyr Gly 
    290                 295                 300                 


Gln Phe Leu Val Asn Cys Asn Ser Ile Gln Asn Leu Pro Ser Leu Thr 
305                 310                 315                 320 


Phe Ile Ile Asn Gly Val Glu Phe Pro Leu Pro Pro Ser Ser Tyr Ile 
                325                 330                 335     


Leu Ser Asn Asn Gly Tyr Cys Thr Val Gly Val Glu Pro Thr Tyr Leu 
            340                 345                 350         


Ser Ser Gln Asn Gly Gln Pro Leu Trp Ile Leu Gly Asp Val Phe Leu 
        355                 360                 365             


Arg Ser Tyr Tyr Ser Val Tyr Asp Leu Gly Asn Asn Arg Val Gly Phe 
    370                 375                 380                 


Ala Thr Ala Ala 
385             


<210>  749
<211>  2200
<212>  DNA
<213>  Homosapiens

<400>  749
cttagctccg ggcgggcggc ggctgctgca gcgggacccg ggagcggggc ccggcgccgc     60

ccgggccgcg gggcgatgtg agccccaggt gtatcccaga gggatccggg tgacttctct    120

gcagactgtt tgccatgaca gcccaccaag gacgggggga ataaagtggg aacccttccc    180

catgcccctc ccacggtcag ctccccgatg gcctgggtga gggcaggctg gctgctctga    240

caccatgggg agctgctgca gctgcctgaa cagagacagc gttccagaca accaccccac    300

caagttcaag gtgacaaatg tggatgatga gggggtggag ctgggctctg gggtgatgga    360

gctgacgcag agtgagctgg tgctgcacct gcatcggcgt gaggccgtcc gctggcctta    420

tctctgcttg cggcgctatg gctacgactc caacctcttc tcctttgaga gtggccgccg    480

atgtcagaca ggccagggaa tatttgcatt taagtgttcc cgggctgagg aaatcttcaa    540

cctccttcag gatctgatgc agtgcaacag catcaatgtg atggaagagc ctgtcatcat    600

cacccgcaat agccaccccg ctgagcttga cctccctcga gccccccagc cacccaatgc    660

tctaggctac actgtctcca gcttttccaa tggctgccct ggagagggcc cacgattctc    720

agctccccgg cggctctcga caagcagcct gcggcacccc tcgcttgggg aagagtccac    780

ccatgccctc attgctcctg atgagcagtc ccacacctat gtcaacacac cggccagtga    840

agatgaccac cgcaggggcc gccactgcct gcagcccctg cctgagggtc aggcaccctt    900

cctcccgcag gcccggggac ctgaccaacg ggacccacag gtgttcttgc agccaggcca    960

ggtgaagttt gtgttgggcc cgacccctgc tcggcggcac atggtgaagt gccagggcct   1020

ctgtcccagc ctgcatgacc ccccacacca caataataac aatgaggccc cttctgagtg   1080

tccagcccag cccaagtgca cctacgagaa cgtcaccggg gggctgtggc gaggggctgg   1140

ctggagactg agcccagagg agccgggctg gaatggcctt gcccaccgcc gggccgccct   1200

gctgcactat gagaacctgc ccccactgcc ccctgtgtgg gaaagccaag cccagcagct   1260

gggaggggag gctggggatg atggggactc gagggatggg ctcacaccct cttccaatgg   1320

cttccctgat ggtgaggagg acgagacccc actgcagaag cccaccagca cccgggccgc   1380

catccgcagc cacggcagct ttcctgtgcc actgacccgc cgccgcggct ccccaagggt   1440

cttcaacttt gatttccgcc ggccggggcc cgagccccca aggcagctta actacatcca   1500

ggtggagcta aagggctggg gtggagaccg ccctaagggg ccccagaacc cctcgagccc   1560

ccaagccccc atgcccacca cccaccctgc ccgaagctca gactcctacg ccgtgattga   1620

cctcaaaaag accgtggcca tgtccaacct gcagagagct ctgccccgag acgatggcac   1680

cgccaggaaa acccggcaca acagcaccga cctgcctctg tagggacttc ccggtcctca   1740

ccaccctctg ccccaccatg atccagcctc tgcctcacac tcctgtcctc tgaacccacc   1800

ctccccaggg ttcagggttg ctttgcagaa ggcatggagg tgggaccaga tgcttccctg   1860

tgctggctgg agtccccaga gatatcagcc accgagtctc ctggtctgtc tccaggctgg   1920

ggagagaagg gtgaccaggc gaggagggag ccgagacgtc aactgtgaag ggttcctgtg   1980

attgcgttta gcgccctccc gttctgtcca tttgtcttgt ctgccgactg tccgtgtgtg   2040

ttttttttgg ttggaatttt gaaacatttt gtacctgttg attttattta tcagtttatt   2100

tttctattta ttgttttaaa tgtaatttaa catatttatt attaatataa ttatttttaa   2160

attctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         2200


<210>  750
<211>  492
<212>  PRT
<213>  Homosapiens

<400>  750

Met Gly Ser Cys Cys Ser Cys Leu Asn Arg Asp Ser Val Pro Asp Asn 
1               5                   10                  15      


His Pro Thr Lys Phe Lys Val Thr Asn Val Asp Asp Glu Gly Val Glu 
            20                  25                  30          


Leu Gly Ser Gly Val Met Glu Leu Thr Gln Ser Glu Leu Val Leu His 
        35                  40                  45              


Leu His Arg Arg Glu Ala Val Arg Trp Pro Tyr Leu Cys Leu Arg Arg 
    50                  55                  60                  


Tyr Gly Tyr Asp Ser Asn Leu Phe Ser Phe Glu Ser Gly Arg Arg Cys 
65                  70                  75                  80  


Gln Thr Gly Gln Gly Ile Phe Ala Phe Lys Cys Ser Arg Ala Glu Glu 
                85                  90                  95      


Ile Phe Asn Leu Leu Gln Asp Leu Met Gln Cys Asn Ser Ile Asn Val 
            100                 105                 110         


Met Glu Glu Pro Val Ile Ile Thr Arg Asn Ser His Pro Ala Glu Leu 
        115                 120                 125             


Asp Leu Pro Arg Ala Pro Gln Pro Pro Asn Ala Leu Gly Tyr Thr Val 
    130                 135                 140                 


Ser Ser Phe Ser Asn Gly Cys Pro Gly Glu Gly Pro Arg Phe Ser Ala 
145                 150                 155                 160 


Pro Arg Arg Leu Ser Thr Ser Ser Leu Arg His Pro Ser Leu Gly Glu 
                165                 170                 175     


Glu Ser Thr His Ala Leu Ile Ala Pro Asp Glu Gln Ser His Thr Tyr 
            180                 185                 190         


Val Asn Thr Pro Ala Ser Glu Asp Asp His Arg Arg Gly Arg His Cys 
        195                 200                 205             


Leu Gln Pro Leu Pro Glu Gly Gln Ala Pro Phe Leu Pro Gln Ala Arg 
    210                 215                 220                 


Gly Pro Asp Gln Arg Asp Pro Gln Val Phe Leu Gln Pro Gly Gln Val 
225                 230                 235                 240 


Lys Phe Val Leu Gly Pro Thr Pro Ala Arg Arg His Met Val Lys Cys 
                245                 250                 255     


Gln Gly Leu Cys Pro Ser Leu His Asp Pro Pro His His Asn Asn Asn 
            260                 265                 270         


Asn Glu Ala Pro Ser Glu Cys Pro Ala Gln Pro Lys Cys Thr Tyr Glu 
        275                 280                 285             


Asn Val Thr Gly Gly Leu Trp Arg Gly Ala Gly Trp Arg Leu Ser Pro 
    290                 295                 300                 


Glu Glu Pro Gly Trp Asn Gly Leu Ala His Arg Arg Ala Ala Leu Leu 
305                 310                 315                 320 


His Tyr Glu Asn Leu Pro Pro Leu Pro Pro Val Trp Glu Ser Gln Ala 
                325                 330                 335     


Gln Gln Leu Gly Gly Glu Ala Gly Asp Asp Gly Asp Ser Arg Asp Gly 
            340                 345                 350         


Leu Thr Pro Ser Ser Asn Gly Phe Pro Asp Gly Glu Glu Asp Glu Thr 
        355                 360                 365             


Pro Leu Gln Lys Pro Thr Ser Thr Arg Ala Ala Ile Arg Ser His Gly 
    370                 375                 380                 


Ser Phe Pro Val Pro Leu Thr Arg Arg Arg Gly Ser Pro Arg Val Phe 
385                 390                 395                 400 


Asn Phe Asp Phe Arg Arg Pro Gly Pro Glu Pro Pro Arg Gln Leu Asn 
                405                 410                 415     


Tyr Ile Gln Val Glu Leu Lys Gly Trp Gly Gly Asp Arg Pro Lys Gly 
            420                 425                 430         


Pro Gln Asn Pro Ser Ser Pro Gln Ala Pro Met Pro Thr Thr His Pro 
        435                 440                 445             


Ala Arg Ser Ser Asp Ser Tyr Ala Val Ile Asp Leu Lys Lys Thr Val 
    450                 455                 460                 


Ala Met Ser Asn Leu Gln Arg Ala Leu Pro Arg Asp Asp Gly Thr Ala 
465                 470                 475                 480 


Arg Lys Thr Arg His Asn Ser Thr Asp Leu Pro Leu 
                485                 490         


<210>  751
<211>  2510
<212>  DNA
<213>  Homosapiens

<400>  751
ctgagtgttg tttctgtgtt ggacaattct atgcaaacta gagccaaaat ggaagagggt     60

gcaagtcccc tcctggggcc ccagacgccc cctcctttct tgctgcctgg agcaggggca    120

gtgctgttag tggctactcc tggtgtgaac agcccatcct ggccaccttc cacaggaaac    180

ctgacctgaa ggacagaaga ggaaggaagc aggctttgcc acaaatgtca gtgcagaact    240

ctggctggcc ccaccaagaa gacagcccca agccccagga tccaggtcca ccagccaact    300

cagacagtga ctcaggccac ctgccggggg aggaccctga ggatacccat gctcagggtc    360

ctgcagttct gagcttgggt tccctttgcc tggacaccaa ccaagccccc aactggactg    420

gacttcagac cctcctgcag caactccctc cgcaggacat tgatgagcgc tactgcctgg    480

cccttgggga ggaggagcgg gccgagctgc agctcttctg tgccaggcgg aagcaggaag    540

ccctgggaca gggggtagcc cgcctggtac ttcccaagct tgaaggacac acctgtgaga    600

agtgtaggga gctgctgaag ccaggggagt acggagtgtt tgcagcccgg gcaggggaac    660

agcgctgctg gcaccagcct tgctttgcct gccaggcctg tggccaggcc ctgataaacc    720

tcatctactt ctaccatgat ggacaactct actgcggccg tcatcatgca gagttgctgc    780

gcccgcgctg cccggcttgt gaccagctga tcttctcctg gcgctgcacc gaggcggagg    840

gacagcgctg gcatgagaac cacttctgtt gccaggactg cgccgggcct ctgggcgggg    900

gacgttatgc cctgcctggg ggaagcccct gctgccccag ctgcttcgag aaccgctact    960

cggatgcagg ctcgagctgg gccggggcac tggaagggca ggcattcctt ggggagactg   1020

gactcgaccg aactgaagga agggaccaaa cctcggtgaa ctctgcaacc ctctcccgaa   1080

cactccttct cgctgctgcc ggcggttcca gcctgcaaac tcagaggggg ctgcctggat   1140

ccagtcccca gcaggagaac cgacctgggg acaaagcgga ggcacccaaa gggcaggagc   1200

aatgccgcct ggagactatt cgtgatccca aggacacccc tttctccacc tgctcctcct   1260

cctctgactc ggaacctgaa ggatttttct taggcgagcg ccttccccag tcctggaaga   1320

cccccggaag cctccaagca gaggacagca acgcctctaa gacgcactgc accatgtgct   1380

agtggcgcag ctcagagagg ggatgtgagt gggaggaaag gggtctgtaa agcgggagaa   1440

caaggctagc ctccccctaa caatcctaga ctgagacgca gtcaggcgca cgcccgcaag   1500

aggcggcgag gtgacaagtt tggagtgcgc ccccttcagt actgcgcgtt ctaagacttt   1560

tggcggagac tttcttggca aaacccattc cccaaagcta cgcttcccct gctgagatag   1620

cccctacccc cacctccaca ggctgggaca gccccgtccc caccatcctc ctcccaagcc   1680

aattaaatga tcacagcacg cgtgacagtt accggctgga gagccggagg tgggaccggg   1740

agcaggggac cgtagaaccg ggccgcgctc ctcccctcct agagttcgtg gaggcgcagc   1800

agagggccgt ccctcttccg gatgtcggac taagcgaaca gcgcccccac tgccggccgg   1860

tagcagccgg aagtgccaga ccggaggtgc gtcattcacc ggcgacgccg atacggttcc   1920

tccaccgagg cccatgcgaa gctttccact atggcttcca gcactgtccc ggtgagcgct   1980

gctggctcgg ctaatgaaac tcccgaaata ccggacaacg tgggagattg gcttcggggc   2040

gtctaccgct ttgccactga taggaatgac ttccggagga actcgatact aaatttggga   2100

ctctttgctg cgggagtttg gctggccagg aacttgagtg acattgacct catggcacct   2160

cagccagggg tgtagccaag tagacaaatg gaatcctgtg ctgaacccga atcttccaaa   2220

aaacagccta caatctgtga ccaccacaag atgtgccctg atggcagctg aagtttgatt   2280

cagatgggca cttttcttcc ccttccctgc ctagtttcct tttgttcctt gagtccacgc   2340

agaattccat tctctggtca gcagacaggc ttaagctaaa gtattgcctc tattctgtaa   2400

agttctgtac atagttccca agcttctgca gggggtgatt tttgctcttg tcctgagaaa   2460

taacagtgct gttttaaaaa acatttgaaa taaataccgc acacaaaggc              2510


<210>  752
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  752

Met Ser Val Gln Asn Ser Gly Trp Pro His Gln Glu Asp Ser Pro Lys 
1               5                   10                  15      


Pro Gln Asp Pro Gly Pro Pro Ala Asn Ser Asp Ser Asp Ser Gly His 
            20                  25                  30          


Leu Pro Gly Glu Asp Pro Glu Asp Thr His Ala Gln Gly Pro Ala Val 
        35                  40                  45              


Leu Ser Leu Gly Ser Leu Cys Leu Asp Thr Asn Gln Ala Pro Asn Trp 
    50                  55                  60                  


Thr Gly Leu Gln Thr Leu Leu Gln Gln Leu Pro Pro Gln Asp Ile Asp 
65                  70                  75                  80  


Glu Arg Tyr Cys Leu Ala Leu Gly Glu Glu Glu Arg Ala Glu Leu Gln 
                85                  90                  95      


Leu Phe Cys Ala Arg Arg Lys Gln Glu Ala Leu Gly Gln Gly Val Ala 
            100                 105                 110         


Arg Leu Val Leu Pro Lys Leu Glu Gly His Thr Cys Glu Lys Cys Arg 
        115                 120                 125             


Glu Leu Leu Lys Pro Gly Glu Tyr Gly Val Phe Ala Ala Arg Ala Gly 
    130                 135                 140                 


Glu Gln Arg Cys Trp His Gln Pro Cys Phe Ala Cys Gln Ala Cys Gly 
145                 150                 155                 160 


Gln Ala Leu Ile Asn Leu Ile Tyr Phe Tyr His Asp Gly Gln Leu Tyr 
                165                 170                 175     


Cys Gly Arg His His Ala Glu Leu Leu Arg Pro Arg Cys Pro Ala Cys 
            180                 185                 190         


Asp Gln Leu Ile Phe Ser Trp Arg Cys Thr Glu Ala Glu Gly Gln Arg 
        195                 200                 205             


Trp His Glu Asn His Phe Cys Cys Gln Asp Cys Ala Gly Pro Leu Gly 
    210                 215                 220                 


Gly Gly Arg Tyr Ala Leu Pro Gly Gly Ser Pro Cys Cys Pro Ser Cys 
225                 230                 235                 240 


Phe Glu Asn Arg Tyr Ser Asp Ala Gly Ser Ser Trp Ala Gly Ala Leu 
                245                 250                 255     


Glu Gly Gln Ala Phe Leu Gly Glu Thr Gly Leu Asp Arg Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Thr Ser Val Asn Ser Ala Thr Leu Ser Arg Thr Leu Leu 
        275                 280                 285             


Leu Ala Ala Ala Gly Gly Ser Ser Leu Gln Thr Gln Arg Gly Leu Pro 
    290                 295                 300                 


Gly Ser Ser Pro Gln Gln Glu Asn Arg Pro Gly Asp Lys Ala Glu Ala 
305                 310                 315                 320 


Pro Lys Gly Gln Glu Gln Cys Arg Leu Glu Thr Ile Arg Asp Pro Lys 
                325                 330                 335     


Asp Thr Pro Phe Ser Thr Cys Ser Ser Ser Ser Asp Ser Glu Pro Glu 
            340                 345                 350         


Gly Phe Phe Leu Gly Glu Arg Leu Pro Gln Ser Trp Lys Thr Pro Gly 
        355                 360                 365             


Ser Leu Gln Ala Glu Asp Ser Asn Ala Ser Lys Thr His Cys Thr Met 
    370                 375                 380                 


Cys 
385 


<210>  753
<211>  3194
<212>  DNA
<213>  Homosapiens

<400>  753
cgcgccctgg tgacagctcg cgcgtgctga tgatggcgat tctttggatg ggaagagacc     60

ttgaaaggac ctctagttta tcctgcaact ccagtcaata tcccacttaa atcattccag    120

gtaatagaga agaggaaacc taaccaatga ctgtggaata atatggaaga agatggaaaa    180

aacttgttta atgggttgag aaagtggcga cttctataag acatggatag atgcaaacat    240

gtagggcggt tacggctcgc ccaggaccac tccatcctga accctcagaa gtggtgctgc    300

ttagagtgtg ccaccaccga gtccgtgtgg gcctgcctca agtgctccca cgtggcctgc    360

ggccgctata ttgaggacca cgccctgaaa cactttgagg agacgggaca cccgctagcc    420

atggaagtcc gggatctcta cgtgttctgt tacctgtgca aggactacgt gctcaatgat    480

aacccagagg gggacctgaa gctgctaaga agctccctcc tggcggtccg gggccagaaa    540

caggacacgc cggtgagacg tgggcggacg ctgcggtcca tggcttcggg tgaggacgtg    600

gtcctgccgc agcgcgctcc tcagggacag ccgcagatgc tcacggctct gtggtaccgg    660

cgtcagcgcc tgctggccag gacgctgcgg ctgtggttcg agaagagctc ccggggccag    720

gcgaagctgg agcagcggcg gcaggaggag gccctggagc gcaagaagga ggaggcgcgg    780

aggcggcggc gcgaggtgaa acggcggctg ctggaggagc tggccagcac ccctccgcgc    840

aagagtgcac ggctgctcct gcacacgccc cgcgacgcgg gcccggctgc ctcgcgcccc    900

gccgccctcc ctacctcacg cagagtgccc gccgccacac tcaagctgcg tcgccagccg    960

gccatggccc caggcgtcac gggcctgcgc aacctgggca acacctgcta catgaactcc   1020

atcctccagg tgctcagcca cctccagaag ttccgagaat gtttcctcaa ccttgaccct   1080

tccaaaacgg aacatctgtt tcccaaagcc accaacggga agactcagct ttctggcaag   1140

ccaaccaaca gctcggccac ggagctgtcc ttgagaaatg acagggccga ggcatgcgag   1200

cgggagggct tctgctggaa cggcagggcc tccattagtc ggagtctgga gctcatccag   1260

aacaaggagc cgagttcaaa gcacatttcc ctctgccgtg aactgcacac cctcttccga   1320

gtcatgtggt ccgggaagtg ggccctagtg tcgcccttcg ccatgctgca ctcagtgtgg   1380

agcctgatcc ctgccttccg cggctacgac caacaggacg cgcaggaatt tctctgcgag   1440

ctgctgcaca aggtgcagca ggaactcgag tctgagggca ccacacgccg gatcctcatc   1500

cccttctccc agaggaagct caccaaacag gtcttaaagg tggtgaatac catatttcat   1560

gggcagctgc tcagtcaggt cacatgtata tcatgcaatt acaaatccaa taccattgag   1620

cccttttggg acctatccct ggaattccct gaacgctatc actgcataga aaaggggttt   1680

gtccctttga atcaaacaga gtgcttgctc actgagatgc tggccaaatt cacagagaca   1740

gaggccctgg aagggagaat ctacgcttgt gaccagtgta acagcaaacg acgaaaatcc   1800

aatcccaaac cccttgttct gagtgaagct agaaagcagt taatgatcta cagactacct   1860

caggttctcc ggctgcacct taaaagattc aggtggtctg gccgtaatca tcgagagaag   1920

attggggtcc atgtcgtctt tgaccaggta ttaaccatgg aaccttactg ctgcagggac   1980

atgctctcct ctcttgacaa agagaccttt gcctatgatc tctccgcagt ggtcatgcat   2040

cacgggaaag ggtttggctc aggacactac acagcctatt gctacaacac agagggaggt   2100

gcgtgcgctt tactctgtgg ggtgggggac acggaaaggg gttgatttgt ccacatttta   2160

ttgttttcct tttatttcca tcccatggat tacctagagg gaaattacat acatcaaaaa   2220

tccagtggaa agaattgtga aaattgggtt gggcgccgtg gctcacacct gtaatcctag   2280

cgctttggga ggccgcggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggc   2340

caacatggtt aaaccccgtc tctactaaaa tagtacaaaa attagccggg cgtggtggtg   2400

ggcactggta atcccaggta ctcaagaggc tgaggcagga gaatcgcttg aacctgggag   2460

gcagaggttg cagtgagcca agattatgcc actgcacttc agcctgggtg acagagcaag   2520

actcttatct caaaaaaaat aaaaagaatt atgaaagttg gattcaaatt ttgggtatat   2580

tactaagtaa caacatatgg ttgttctaag aattaaaagg aactgacatg taaaagtgct   2640

tagaacagga cctaggccct gtgcaatggc tcacacctgt aattccaaca ctttgggagg   2700

cagaggcggg aggattgctt gaggccgagg gttcaagact agcctgggca acatagcgag   2760

actgcatctc tacaaaaaat ttaaaaatta tccaggtgta atggtgtgca cctgtgatcc   2820

tagctacttg ggaggctgag gtgggagaat tgctcaagcc caggagtttg aagttgcaat   2880

gagctatgat ttcaccactg cattctagcc tgggcaacag agtgagatcc tgactcaaat   2940

aaataaataa gaagagcagt tgcctaccac atagtactta ttcagtcagt gttagaggat   3000

attgtagtat tatcaaaagt attggttatt gataatatta ctgttttgtg gtaatgctac   3060

ttctgcacac cccagtttcc ttcttggtta tgcagaaaca gtagaacctg tgtaacctca   3120

aggagatatt gtatgaatct cactagccgc agcttataat aaagccgaga acatttaaaa   3180

aaaaaaaaaa aaaa                                                     3194


<210>  754
<211>  640
<212>  PRT
<213>  Homosapiens

<400>  754

Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Ala Cys Ala Leu Leu Cys Gly Val Gly Asp Thr Glu Arg Gly 
625                 630                 635                 640 


<210>  755
<211>  2478
<212>  DNA
<213>  Homosapiens

<400>  755
gtatttccgg agtcccttct gagacagaag gttgtgttgg ggaactgaag gagtttctgt     60

gggcggacag ggaaccctgc gtttctactg tgtgattctg ccaccttcct ggcccgacgc    120

catgggagtg acttgtgtgt cccagatgcc tgtggccgag ggcaagagtg ttcagcaaac    180

cgtagagctc cttacccgga aattggagat gcttggggca gagaagcaag gaacattttg    240

tgtggactgt gagacttacc atacggccgc ctctaccctt ggcagccaag gtcagaccgg    300

gaagctgatg tatgtgatgc acaactcaga gtacccattg agctgtttcg ccctctttga    360

gaatggccct tgccttattg ctgacaccaa ctttgatgtg cttatggtga agctcaaggg    420

ctttttccag agtgctaagg ccagcaagat tgagacccgg ggcaccaggt accagtactg    480

tgacttcctg gtgaaggtgg gcacggtcac aatggggccc agtgcccggg gcatctctgt    540

ggaggtggag tatggcccct gtgtggtagc tagtgactgc tggagtctgc tgctcgagtt    600

cctacagagt tttctaggca gccacacacc aggggctccc gcagtgtttg ggaacagaca    660

tgatgcggtc tacggcccag cagataccat ggtccagtac atggaactct tcaacaagat    720

ccgcaagcag cagcaggtgc cggtggctgg gattcgttag tgatgagcag ctgccagctg    780

agctctgtca ccaggggtac tccacaggag gagcaggtgc tgactttcag gtccctggac    840

cccagaaacc cagggtagac atggactcta ctctccttct ctggttctca gctgtggctt    900

ttgttctggg gctgagtccc ctccccaacc ccctgactct cacacatagc cccccatcag    960

ctgttttact ccgtgcctta ctggatttgg cctgtcctca agaatggtaa ttatgaagag   1020

tggagaagtt tggaccttgc ctcctttagg ggaaaggtag gacaggaatg tccctgcctg   1080

gtactggtgg gggaaatagt ccgtatcccc aactattaag gatttgtccc aggccaatgg   1140

tgaacatgct gcattttatg tttggattgt gctgtaataa gagcctcttc cttccctcag   1200

aggatgtggc tgggcttcta tcctagagat ggagtagaag gcacaactgg tttgatagtt   1260

actattttct gacctgtttg ctgaagtgat ttgcgaattg actttcctag ggtgttgcct   1320

gagtcctttg aaatctcctt ctgacatctt tcccttctgt tgtgaaatat gttaagccac   1380

aggccaaact gctataagat cgaagtttgt ttttttctca cctaataata gagaggtaat   1440

cagatggtct agggcagatt taactctaca aggttatcag gaactttgtt tccttctgtc   1500

ttattcagcc attcccagta tgttttctta cccataagat caaagcagac tcatcagctc   1560

catatctgca ttccactggg gaaagagaga gagaaaagag cagattttaa aaaaaagata   1620

tgactgagca ttgctcagat cactgtggcc acactttgct gaaagagatg ctgggacata   1680

gaacctctta tctgggcagt catgtgctga gttaaaactc agggattctg tgactacaag   1740

atgaaagaca atttggttgc tgagatgcag ttaatggctt ctgttacatg gagctcaatg   1800

gacgtgccca ggaatgcttt tggctgttat tttgcagtta atacctcctg taactaaagc   1860

atttgtttat gagttgactt gagagaaggg ctgatctcag agccgctttg agctaagttg   1920

gattagtcac actaggaagt taattccaca cctttcgtct aagtctcagt attgaggcct   1980

ctccagttct catgcaccct gatcttaggg ttagaatact tgaccctgat acctgcacca   2040

tgcttcatgg ttcctgagct ctttctcctg tttcatttga gcctccaaac tacatatttg   2100

gtcatattgc ctgcctaccc catgcctgct gcagaaatat tcatccaggt taaccttgat   2160

atacacagag atggtcttgg agaattgtga atgtatgtac tgtattgtca tcaaggatac   2220

tgtcccttat ttgaaggcat ctaaagagaa actgttttca gatccaagtg ctcagatcta   2280

aagcctctgc aacaagtcag gtggtggtca tgtttccctt ctagttttgg ctgacaggaa   2340

gctcagttca gtaccataac tacagaacct gtcatctgta ttttttgttc tcaccccgtt   2400

tttgttattt tgtttctggt tttttatatt gaggtatgtt ttagatatag tttacaaaaa   2460

taaaacgcac agatctta                                                 2478


<210>  756
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  756

Met Gly Val Thr Cys Val Ser Gln Met Pro Val Ala Glu Gly Lys Ser 
1               5                   10                  15      


Val Gln Gln Thr Val Glu Leu Leu Thr Arg Lys Leu Glu Met Leu Gly 
            20                  25                  30          


Ala Glu Lys Gln Gly Thr Phe Cys Val Asp Cys Glu Thr Tyr His Thr 
        35                  40                  45              


Ala Ala Ser Thr Leu Gly Ser Gln Gly Gln Thr Gly Lys Leu Met Tyr 
    50                  55                  60                  


Val Met His Asn Ser Glu Tyr Pro Leu Ser Cys Phe Ala Leu Phe Glu 
65                  70                  75                  80  


Asn Gly Pro Cys Leu Ile Ala Asp Thr Asn Phe Asp Val Leu Met Val 
                85                  90                  95      


Lys Leu Lys Gly Phe Phe Gln Ser Ala Lys Ala Ser Lys Ile Glu Thr 
            100                 105                 110         


Arg Gly Thr Arg Tyr Gln Tyr Cys Asp Phe Leu Val Lys Val Gly Thr 
        115                 120                 125             


Val Thr Met Gly Pro Ser Ala Arg Gly Ile Ser Val Glu Val Glu Tyr 
    130                 135                 140                 


Gly Pro Cys Val Val Ala Ser Asp Cys Trp Ser Leu Leu Leu Glu Phe 
145                 150                 155                 160 


Leu Gln Ser Phe Leu Gly Ser His Thr Pro Gly Ala Pro Ala Val Phe 
                165                 170                 175     


Gly Asn Arg His Asp Ala Val Tyr Gly Pro Ala Asp Thr Met Val Gln 
            180                 185                 190         


Tyr Met Glu Leu Phe Asn Lys Ile Arg Lys Gln Gln Gln Val Pro Val 
        195                 200                 205             


Ala Gly Ile Arg 
    210         


<210>  757
<211>  2005
<212>  DNA
<213>  Homosapiens

<400>  757
gcggattccc gccccgaggt ttctaaatcc agacattccc gtttggctga gcactctagg     60

cctacatcca tgaagctagg agagcgacac tcaaagactg cactattgag agaagctaac    120

gttaaaggca gtgaatatat tcgggagtcc agctccggaa cccgggagct cttttagtgg    180

gaggggcggc gctgatggcg cttctggcct ccgaatgcta gggggcgctg tgatcgccgg    240

gcggcctctt gggcgctggg agtccaccgc gcaagcgcat cctggccttt cttcagtccc    300

cacgtgcgat ccttcccggc aactttttcg agaaaaatgc ccaaattcaa ggcggcccgt    360

ggggtggggg gtcaggaaaa acatgcgccc ctggccgatc agatcctggc tgggaatgcg    420

gtgcgggcgg gggtccggga gaagcggcgg ggtcgcggga caggagaagc ggaggaagag    480

tatgtggggc cccggctgag ccgacggatt ttgcagcaag cacggcagca acaggaggaa    540

ctcgaggccg agcatgggac tggggacaag cccgcggcgc cgcgggaacg caccacgcgg    600

ctgggtccaa gaatgcctca ggatggatca gatgacgagg acgaggagtg gcccaccctg    660

gagaaggctg ccacaatgac agcagcgggc catcatgcag aggtggttgt ggaccctgag    720

gatgagcgtg ccatagagat gttcatgaac aagaaccctc ctgccaggcg caccctggct    780

gacatcatca tggagaagct gactgagaag cagacagagg ttgagacagt catgtcagag    840

gtgtcgggct tccctatgcc ccagctggac ccccgggtcc tagaagtgta caggggggtc    900

cgggaggtat tatctaagta ccgcagtgga aaactgccca aggcatttaa gatcatccct    960

gcactctcca actgggagca aatcctctac gtcacagagc cggaggcctg gactgcagct   1020

gccatgtacc aggccaccag gatttttgcc tctaacctga aggaacgcat ggcccagcgc   1080

ttctacaacc ttgtcctgct ccctcgagta cgagatgacg ttgctgaata caaacgactc   1140

aacttccatc tctacatggc tctcaagaag gcccttttca aacctggagc ctggttcaaa   1200

gggatcctga ttccactgtg cgagtctggc acttgtaccc tccgggaagc catcattgtg   1260

ggtagcatca tcaccaagtg ctccatccct gtgttgcact ccagtgcggc catgctgaaa   1320

attgctgaga tggaatacag cggtgccaac agcatcttcc tgcgactgct gctggataag   1380

aagtatgcac tgccttaccg ggtgctggat gccctagtct tccacttcct ggggttccgg   1440

acagagaagc gtgaactgcc tgtgctgtgg caccagtgcc tcctgacttt ggtccagcgc   1500

tacaaggccg acttggccac agaccagaaa gaggccctct tagaactgct ccggctgcag   1560

ccccatccac agctatcgcc cgaaatcagg cgtgagcttc agagtgcagt cccccgcgat   1620

gtggaagatg ttcccatcac cgtggagtga ggaaaacagt cagctgtcct ggccaaaggg   1680

gtttggaagg acaccaagac ccccgttggt gactgaagat gacactgagc tttaatggct   1740

gaagacccag atcagggcag tgacagatca cagggacatc tgtggctccc agtccaggac   1800

aggaaggact gagggtctgg ctggttccct cttccattct aggcccttat ccctgtttag   1860

ttctgagagc caacttgaga taccatatgc tagcattccc agtccccagc tggggcttgg   1920

tgtgagtact ttttctatgg ctattgtgtc aggtcactgt ggataaaggc aaagacagat   1980

atttattgaa aaaaaaaaaa aaaaa                                         2005


<210>  758
<211>  437
<212>  PRT
<213>  Homosapiens

<400>  758

Met Pro Lys Phe Lys Ala Ala Arg Gly Val Gly Gly Gln Glu Lys His 
1               5                   10                  15      


Ala Pro Leu Ala Asp Gln Ile Leu Ala Gly Asn Ala Val Arg Ala Gly 
            20                  25                  30          


Val Arg Glu Lys Arg Arg Gly Arg Gly Thr Gly Glu Ala Glu Glu Glu 
        35                  40                  45              


Tyr Val Gly Pro Arg Leu Ser Arg Arg Ile Leu Gln Gln Ala Arg Gln 
    50                  55                  60                  


Gln Gln Glu Glu Leu Glu Ala Glu His Gly Thr Gly Asp Lys Pro Ala 
65                  70                  75                  80  


Ala Pro Arg Glu Arg Thr Thr Arg Leu Gly Pro Arg Met Pro Gln Asp 
                85                  90                  95      


Gly Ser Asp Asp Glu Asp Glu Glu Trp Pro Thr Leu Glu Lys Ala Ala 
            100                 105                 110         


Thr Met Thr Ala Ala Gly His His Ala Glu Val Val Val Asp Pro Glu 
        115                 120                 125             


Asp Glu Arg Ala Ile Glu Met Phe Met Asn Lys Asn Pro Pro Ala Arg 
    130                 135                 140                 


Arg Thr Leu Ala Asp Ile Ile Met Glu Lys Leu Thr Glu Lys Gln Thr 
145                 150                 155                 160 


Glu Val Glu Thr Val Met Ser Glu Val Ser Gly Phe Pro Met Pro Gln 
                165                 170                 175     


Leu Asp Pro Arg Val Leu Glu Val Tyr Arg Gly Val Arg Glu Val Leu 
            180                 185                 190         


Ser Lys Tyr Arg Ser Gly Lys Leu Pro Lys Ala Phe Lys Ile Ile Pro 
        195                 200                 205             


Ala Leu Ser Asn Trp Glu Gln Ile Leu Tyr Val Thr Glu Pro Glu Ala 
    210                 215                 220                 


Trp Thr Ala Ala Ala Met Tyr Gln Ala Thr Arg Ile Phe Ala Ser Asn 
225                 230                 235                 240 


Leu Lys Glu Arg Met Ala Gln Arg Phe Tyr Asn Leu Val Leu Leu Pro 
                245                 250                 255     


Arg Val Arg Asp Asp Val Ala Glu Tyr Lys Arg Leu Asn Phe His Leu 
            260                 265                 270         


Tyr Met Ala Leu Lys Lys Ala Leu Phe Lys Pro Gly Ala Trp Phe Lys 
        275                 280                 285             


Gly Ile Leu Ile Pro Leu Cys Glu Ser Gly Thr Cys Thr Leu Arg Glu 
    290                 295                 300                 


Ala Ile Ile Val Gly Ser Ile Ile Thr Lys Cys Ser Ile Pro Val Leu 
305                 310                 315                 320 


His Ser Ser Ala Ala Met Leu Lys Ile Ala Glu Met Glu Tyr Ser Gly 
                325                 330                 335     


Ala Asn Ser Ile Phe Leu Arg Leu Leu Leu Asp Lys Lys Tyr Ala Leu 
            340                 345                 350         


Pro Tyr Arg Val Leu Asp Ala Leu Val Phe His Phe Leu Gly Phe Arg 
        355                 360                 365             


Thr Glu Lys Arg Glu Leu Pro Val Leu Trp His Gln Cys Leu Leu Thr 
    370                 375                 380                 


Leu Val Gln Arg Tyr Lys Ala Asp Leu Ala Thr Asp Gln Lys Glu Ala 
385                 390                 395                 400 


Leu Leu Glu Leu Leu Arg Leu Gln Pro His Pro Gln Leu Ser Pro Glu 
                405                 410                 415     


Ile Arg Arg Glu Leu Gln Ser Ala Val Pro Arg Asp Val Glu Asp Val 
            420                 425                 430         


Pro Ile Thr Val Glu 
        435         


<210>  759
<211>  2095
<212>  DNA
<213>  Homosapiens

<400>  759
gcgcctgtca gggaagcggc gcgcgcgcgc gggcggcggg cgggctgggg atccgccgcg     60

cagtgccagc gccagcgcca gacccgcgcc ccgcgctctc cggcccgtcg cctgccttgg    120

gactcgcgag cccgcactcc cgccctgcct gttcgctgcc cgagtatgga gctgctgtgt    180

tgcgaaggca cccggcacgc gccccgggcc gggccggacc cgcggctgct gggggaccag    240

cgtgtcctgc agagcctgct ccgcctggag gagcgctacg taccccgcgc ctcctacttc    300

cagtgcgtgc agcgggagat caagccgcac atgcggaaga tgctggctta ctggatgctg    360

gaggtatgtg aggagcagcg ctgtgaggag gaagtcttcc ccctggccat gaactacctg    420

gatcgctacc tgtcttgcgt ccccacccga aaggcgcagt tgcagctcct gggtgcggtc    480

tgcatgctgc tggcctccaa gctgcgcgag accacgcccc tgaccatcga aaaactgtgc    540

atctacaccg accacgctgt ctctccccgc cagttgcggg actgggaggt gctggtccta    600

gggaagctca agtgggacct ggctgctgtg attgcacatg atttcctggc cttcattctg    660

caccggctct ctctgccccg tgaccgacag gccttggtca aaaagcatgc ccagaccttt    720

ttggccctct gtgctacaga ttataccttt gccatgtacc cgccatccat gatcgccacg    780

ggcagcattg gggctgcagt gcaaggcctg ggtgcctgct ccatgtccgg ggatgagctc    840

acagagctgc tggcagggat cactggcact gaagtggact gcctgcgggc ctgtcaggag    900

cagatcgaag ctgcactcag ggagagcctc agggaagcct ctcagaccag ctccagccca    960

gcgcccaaag ccccccgggg ctccagcagc caagggccca gccagaccag cactcctaca   1020

gatgtcacag ccatacacct gtagccctgg agaggccctc tggagtggcc actaagcaga   1080

ggaggggccg ctgccaccca cctccctgcc tccaggaacc acaccacatc taagcctgaa   1140

ggggcgtctg ttcccccttc acaaagccca agggatctgg tcctacccat ccccgcagtg   1200

tgcactaagg ggcccggcca gccatgtctg catttcggtg gctagtcaag ctcctcctcc   1260

ctgcatctga ccagcagcgc ctttcccaac tctagctggg ggtgggccag gctgatggga   1320

cagaattgga tacatacacc agcattcctt ttgaacgccc ccccccaccc ctgggggctc   1380

tcatgttttc aactgccaaa atgctctagt gccttctaaa ggtgttgtcc cttctagggt   1440

tattgcattt ggattggggt ccctctaaaa tttaatgcat gatagacaca tatgaggggg   1500

aatagtctag atggctcctc tcagtacttt ggaggcccct atgtagtccg tgctgacagc   1560

tgctcctaga gggaggggcc taggcctcag ccagagaagc tataaattcc tctttgcttt   1620

gctttctgct cagcttctcc tgtgtgattg acagctttgc tgctgaaggc tcattttaat   1680

ttattaattg ctttgagcac aactttaaga ggacataatg ggggcctggc catcccacaa   1740

gtggtggtaa ccctggtggt tgctgttttc ctcccttctg ctactggcaa aaggatcttt   1800

gtggccaagg agctgctata gcctggggtg gggtcatgcc ctcctctccc attgtccctc   1860

tgccccatcc tccagcaggg aaaatgcagc agggatgccc tggaggtggc tgagcccctg   1920

tctagagagg gaggcaagcc ctgttgacac aggtctttcc taaggctgca aggtttaggc   1980

tggtggccca ggaccatcat cctactgtaa taaagatgat tgtgaaataa aactggcttt   2040

ggcttcttgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        2095


<210>  760
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  760

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
1               5                   10                  15      


Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
            20                  25                  30          


Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
        35                  40                  45              


Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                85                  90                  95      


Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
            100                 105                 110         


Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
    130                 135                 140                 


Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
145                 150                 155                 160 


Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                165                 170                 175     


Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
        195                 200                 205             


Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
    210                 215                 220                 


Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
225                 230                 235                 240 


Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                245                 250                 255     


Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
            260                 265                 270         


Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
        275                 280                 285             


Ala Ile His Leu 
    290         


<210>  761
<211>  1805
<212>  DNA
<213>  Homosapiens

<400>  761
gcacactacg ccagaacaag atggccgacg cggcggccac agctggggcc ggtggctccg     60

gaacgagatc gggaagtaaa cagtccacta accctgccga taactatcat ctggcccgga    120

ggagaaccct gcaggtggtt gtgagctcct tgctgacaga ggcagggttt gagagtgccg    180

agaaagcatc cgtggaaacg ctgacagaga tgctgcagag ctacatttca gaaattggga    240

gaagtgccaa gtcttactgt gagcacacag ccaggaccca gcccacactg tccgatatcg    300

tggtcacact tgttgagatg ggtttcaatg tggacactct ccctgcttat gcaaaacggt    360

ctcagaggat ggtcatcact gctcctccgg tgaccaatca gccagtgacc cccaaggccc    420

tcactgcagg gcaggaccga ccccacccgc cgcacatccc cagccatttt cctgagttcc    480

ctgatcccca cacctacatc aaaactccga cgtaccgtga gcccgtgtca gactaccagg    540

tcctgcggga gaaggctgca tcccagaggc gcgatgtgga gcgggcactt acccgtttca    600

tggccaagac aggcgagact cagagtcttt tcaaagatga cgtcagcaca tttccattga    660

ttgctgccag acctttcacc atcccctacc tgacagctct tcttccgtct gaactggaga    720

tgcaacaaat ggaagagcag attcctcgga gcaggatgaa cagacagaca cagagaacct    780

tgctcttcat atcagcatga tagagtctcg ctccgtcacc caggctggag tgcagtggca    840

agatcttggc tcactgcaac ctccgcctcc tgggttcaag cgattctcca gcctcagcct    900

cctgagtagc tggaattaca ggaggattct ggagccgaga aggagaacac ctctgtcctg    960

cagcagaacc cctccttgtc gggtagccgg aatggggagg agaacatcat cgataaccct   1020

tatctgcggc cggtgaagaa gcccaagatc cgcaggaaga agccagatac attctagaga   1080

attgtgagac tttgccctaa gctgccaagt gctccccaag gagatcggtc accaggagag   1140

cagccacaaa ggtcaagaaa gacacacacg gaagcaaacc caggctctgt gctccttcca   1200

gcccttgctg gtgcagatgc taccccacaa gcttgtcaga tcgcccaggt gacgggccag   1260

gcgcagccat cgggaaggtc attcagccaa cccagaggat gtagaccctg tcctcaagaa   1320

gtgcagggcg agttctgccg tgccctctga aatactctcc ctcctctcag agccctccct   1380

cgagagcctg agtgcaccat gtcttgtggc ctcgcctgaa gccttcctct ggcttcacag   1440

aacgctctgg aactctgggg tctggtcagg gagtgtgtcc tcagcttgtc tggaggaggc   1500

ctgcatccct cctgagctct tggaggtgcc caggaaccct gcttctcctc acagggcctg   1560

gccatatagc cagctccaac ccaaagccct gcacagtgcc tcacccactc ccttctcctg   1620

gtctctcctc aaaagaattt tacatgattt taaaataata atagctttca tttacatagt   1680

gcttacattt atatagcact taactatgtg cgatgtacta atttaagtac tttatattaa   1740

ctcatataat aaatggacac aacacaaaac tcaaaaggta caaaagaata aaacagttaa   1800

aaact                                                               1805


<210>  762
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  762

Met Ala Asp Ala Ala Ala Thr Ala Gly Ala Gly Gly Ser Gly Thr Arg 
1               5                   10                  15      


Ser Gly Ser Lys Gln Ser Thr Asn Pro Ala Asp Asn Tyr His Leu Ala 
            20                  25                  30          


Arg Arg Arg Thr Leu Gln Val Val Val Ser Ser Leu Leu Thr Glu Ala 
        35                  40                  45              


Gly Phe Glu Ser Ala Glu Lys Ala Ser Val Glu Thr Leu Thr Glu Met 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Ser Glu Ile Gly Arg Ser Ala Lys Ser Tyr Cys 
65                  70                  75                  80  


Glu His Thr Ala Arg Thr Gln Pro Thr Leu Ser Asp Ile Val Val Thr 
                85                  90                  95      


Leu Val Glu Met Gly Phe Asn Val Asp Thr Leu Pro Ala Tyr Ala Lys 
            100                 105                 110         


Arg Ser Gln Arg Met Val Ile Thr Ala Pro Pro Val Thr Asn Gln Pro 
        115                 120                 125             


Val Thr Pro Lys Ala Leu Thr Ala Gly Gln Asp Arg Pro His Pro Pro 
    130                 135                 140                 


His Ile Pro Ser His Phe Pro Glu Phe Pro Asp Pro His Thr Tyr Ile 
145                 150                 155                 160 


Lys Thr Pro Thr Tyr Arg Glu Pro Val Ser Asp Tyr Gln Val Leu Arg 
                165                 170                 175     


Glu Lys Ala Ala Ser Gln Arg Arg Asp Val Glu Arg Ala Leu Thr Arg 
            180                 185                 190         


Phe Met Ala Lys Thr Gly Glu Thr Gln Ser Leu Phe Lys Asp Asp Val 
        195                 200                 205             


Ser Thr Phe Pro Leu Ile Ala Ala Arg Pro Phe Thr Ile Pro Tyr Leu 
    210                 215                 220                 


Thr Ala Leu Leu Pro Ser Glu Leu Glu Met Gln Gln Met Glu Glu Gln 
225                 230                 235                 240 


Ile Pro Arg Ser Arg Met Asn Arg Gln Thr Gln Arg Thr Leu Leu Phe 
                245                 250                 255     


Ile Ser Ala 
            


<210>  763
<211>  667
<212>  DNA
<213>  Homosapiens

<400>  763
gaagactgtt tgtccagcgt gtatttcagg atatctggat cccttttatt gactcacaat     60

ttgtggcacc actttctcat cccagaactt cattcttatt tctctcctca tctggcctcc    120

caagtgctcc gttgagctga tgaaaagttc tttgtactcc ctcaacgtgt cggaaacagg    180

aggccacaca gcacagcttt gtttggggtg ggcaggagtc aggagtcttg agcagatgca    240

tcactgtgaa gaagaacgac atgtcggggc tgcacctgtc ctcccgtcgg catttgacga    300

aagctccctg aagcggggca gcactctcct cctgagagat ttaccattta ttgcccctgt    360

gaggaatgtg tgcttgggaa ctgccaagtc ttaccccttc tggaagaaga ggttttctct    420

gacaagagcc tagagcgtcg gctctattat gctgggactt gacagaggag ccatggggtt    480

taaacagtag gaaagaggag ccacggtgcc cagcccatct cttagtcttc cattcccttg    540

gtgaatttgg aaacttgaaa aacttgggga cttgacagca ggctccatgt tcttctggcc    600

tcactgtact gtgtaaggaa agagctgctt gtcaggaacg gaagagggga cgctagtaaa    660

aaaaaaa                                                              667


<210>  764
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  764

Met Lys Ser Ser Leu Tyr Ser Leu Asn Val Ser Glu Thr Gly Gly His 
1               5                   10                  15      


Thr Ala Gln Leu Cys Leu Gly Trp Ala Gly Val Arg Ser Leu Glu Gln 
            20                  25                  30          


Met His His Cys Glu Glu Glu Arg His Val Gly Ala Ala Pro Val Leu 
        35                  40                  45              


Pro Ser Ala Phe Asp Glu Ser Ser Leu Lys Arg Gly Ser Thr Leu Leu 
    50                  55                  60                  


Leu Arg Asp Leu Pro Phe Ile Ala Pro Val Arg Asn Val Cys Leu Gly 
65                  70                  75                  80  


Thr Ala Lys Ser Tyr Pro Phe Trp Lys Lys Arg Phe Ser Leu Thr Arg 
                85                  90                  95      


Ala 
    


<210>  765
<211>  4598
<212>  DNA
<213>  Homosapiens

<400>  765
atgcccagca tcatggatga acacggacta tatggggtgg ttgaaaaggt ggcagggagg     60

gagtcgaatg cccaggaaaa ccatgggctg gctgtgccca ccccctcggt tccagatgat    120

tttgcagaca aagaagtgac aggtaccagc tcactagtca atggcaacct ccgactgtac    180

agctctgtgg cccccccacc gcctcctgtg ccagccccag cacccccagc tccagcatct    240

cctcacacag tggggactcg tctctttccc cctgggggtg tcaccaagtg gaaatcagat    300

gtagcactga atggcaggca ggcagaggcc accagagcca gccccccgag aagccctgct    360

gagccaaagg ggagcgccct gggacctaac ccagagcccc atctcacctt cccccgttct    420

ttcaaagtgc ctcccccaac cccagtcagg acttcgtcca tcccagttca ggaagcacaa    480

gaggctcccc gaaaggaaga gggggccacc aagaaggctc ccagccgact cccactgcct    540

cccagcttcc acatccgccc cgcctcccag gtctacccag acagggcccc cgagccagac    600

tgccctgggg agctcaaggc cacagcacca gccagcccaa ggcttggcca gtcccagtcc    660

caagcagatg aacgagctgg gactccgcct ccagcccctc ccctgccccc tcctgcaccc    720

cccctccctc ccccagcacc cccacttccc ccagctgcac ctcctttgcc ctgtgctcag    780

aaggcagccc atccacctgc tgggtttaca aaaaccccta aatccagctc tcctgctctc    840

aaacccaaac ccaacccccc cagcccagag aacacagcgt cttcagcacc tgtggactgg    900

agggacccca gccagatgga aaagctgcgg aacgagctgg cagcctatct ctgtggctcc    960

aggagagagg accgattcct cagtcacagg ccaggcccaa cagtggcccc tcagagcaag   1020

gagggcaaga agggcccccg cctgcctgag aaggagactc tcctgagcct gccagcaaag   1080

gacactcccc caggtgttcc tgaaaagagt cttggcggca gcagcctgac agagacagag   1140

gctgccccca gcctgaccct gccctctgtg gactacattc cccaagactc tccaactccc   1200

agtgtgcggc agatccggaa tgagctggag gcccggctct cctcagcagc agagaaggag   1260

gctaagccca gcataggatc tctgccccct aagcctcggc tagaaggggg aagaatttgt   1320

gaaaacgggg ctgatgatga caaactctcc aagcctgtgg ccaagaatct gccacctcaa   1380

tccaccaccc tgctgccaac tacatcactc cagcccaagg ctatgttggg accagccata   1440

ccacccaagg ccacacctga gccagccata ccacccaagg ctacactttg gccagccaca   1500

ccacccaagg ccacacttgg gccagccaca ccactcaagg ccacatctgg gccaaccaca   1560

ccactcaagg ccacatctgg ccctgccata gcatctacag ccacaactct gcccaccacc   1620

acatcccaac tgatggcaga gaaggactca ggcccagctg gccagccaga gaagccagca   1680

tctcaagaag tttccactcc ctcccaggca aggggagagg ggtccccctc agaggccact   1740

aggctgccca cacagggagc ccgctcatct gcagccttcc caccaaagac atctcctggt   1800

ggaggagagg tgccatgtct ctacaagccc cactgccacc agagcagcct cagccgtgag   1860

gttgctgtgg tgatgcccac cctggccaga ggaggggctg cagggccagg ggagcccgtg   1920

gaggtgaagg agcccccagg gctgccagcc aagcctcctg cctcggccca gcccactgat   1980

gaactcctca ggcacccggt gactggggag gtggtggagc ggggctcgcc gatggccctg   2040

ctcctggcgg ccaggcagag ggctcagaag ggaaggtctg taggggctgc cctgggtcgg   2100

tcctctctgc caggaagtct ccgtgaccac agccaccaag ccgaggccag ctctgacagc   2160

atcttccaca gccagggcac gcccaactcc ttcactgtgg tgcccaagtt acccaaggag   2220

gctgagaagg actccccgct gacgaccgaa atacccaata agtgggggcc gcggctggga   2280

agagacgcag agggcacaga gctgagccgc aggcacaact ggacaaagcc agagccccag   2340

gcccctgtgg cctgggaaag agtagctccc tccaacctcc cccagggcca cccgctgccc   2400

aagtccttct cctccccacc ttctccttcg aacaagaggg aggaggagga ggaggagttc   2460

aacttcgagg tcatcccacc gccgccagag ttcagcaatg accctgagcc cccggccccg   2520

gccctccagt atctgggccg ccagagctcc cctccccgga acaactactc agacttgagg   2580

cagctcccga acgctggccc cggggcgccc ccggctctcg gcttctcgcg ctttcccgcg   2640

ggcgcgcgct acgccggggc tgggggcctg gagcgcttct cgggaggggg ccgctcgctc   2700

ataaagaagc gcctgtacgt cggggagccg caccgaggcc cagggctacc ccacggtggc   2760

accggccgca gcctgagctc tcccaactgc ttcgggccgc agcccggagg ccccgagatg   2820

cggcgcgtga actcggcggg tcgcgcgccc cccggaggcc tgcacgcgcc gaggctgtcc   2880

ctggagggcg ccgcccgggg cgccgcggag gccaagcaca aagcgcccgg cagcgccgac   2940

tacggcttcg ccccagctgc cggcaggtct ccctacacca ccacccgcta tggaagcccc   3000

atcaacacgt tcaccgtgag gcctgggacc cgccatccca tctcctatgt ctgctcaggg   3060

gcccatcgga aagccacctc ctgagccagg ggttctctta gctctactcc aacaaactgt   3120

gtctttaagg atctgggcac ttgtttcttg tggggggtgg gaggtacaca gcaggtgttg   3180

ggcgacctga ctcagacaca gaggagtctt tgatccccaa agaccaacga tgagaagcag   3240

tggcccagga agaccgagag tgggcttctg tttcccaaag cgctggtgtg actgtggact   3300

gtttacacgt ggggggtggg aggggaagga gggtagagag aaggaaccat taaggacctg   3360

ggcgctgagt ttctgctctc tggtactatc tgctttagca agagttattt aaaacagttt   3420

tacaagcacg gcctactgag caggttctga aagcaagggg tggggcactg actgaactgg   3480

aacccatcga gatagctgtg attgcctgtc aggcccttgc aaagggctga ggcccagctc   3540

tgtctggtgg gtgtgcaggg caccgaaggg agatctttag cctccatcac ctgccatccc   3600

aagcaagagt ggacacctgg ggttcctagc cgcattgagg tgggaccagg aatgtgtatg   3660

tataacatgt ggagaaggac catgtgtggg gtggggagtg aagctcccac atgtggaatg   3720

gaagcccttt gcattggcca agggcagagg tgggagattg atggttcatt tttccttggc   3780

cctagccctt agctacaggg aggcctagag agaggacact tggcaagttt aggatgggaa   3840

acaaggttaa gcctggcttt gctattcaga cctgtgcagc cctgattttg gggactgggc   3900

ccaaggagcc atgagtctta ggcttgacac taggggcctt acatggccag gtctcatatg   3960

ggatttggag aaggcatttt tcctaacact gatactacaa gtcaccaata ctcttgatgc   4020

cttaagatgc tagaaagcct tggagagtgg aggcagcaga gatgggaatg gaggtctgaa   4080

gaagcttgct gctgttgggg aatgtgtttg ggaaagtcaa gagtggtagg attggttggc   4140

tgggcgcggt ggctcacacc tgtaatccca gcactttggg aggccgaggc cggtggatca   4200

cttgaggtca gaagttcgag accagcctgc ccaaatggtg aaaccccatc tctactaaaa   4260

atacggaaaa aaaaaaaaaa agagtgctag gattgggcca gttaagagca ggggagacct   4320

ggctgggcat ggtggctcac acctgtaatt ctagcacttt gggaggctga ggcgggtgga   4380

tcatgaggtc aagagattaa gaccatcctg gcctacatgg cgaaaccctg tctctactaa   4440

aaataaaaaa atgacctggg catggtggtg ggcgcctgta gtcccagcta ctcggggcgc   4500

tgaggcagga gaatcgctcg aacccaggag gtggaggttg cagtgagccg agattgcaca   4560

attgcactcc agcctggcga cagagcgaga ctcgtctc                           4598


<210>  766
<211>  1027
<212>  PRT
<213>  Homosapiens

<400>  766

Met Pro Ser Ile Met Asp Glu His Gly Leu Tyr Gly Val Val Glu Lys 
1               5                   10                  15      


Val Ala Gly Arg Glu Ser Asn Ala Gln Glu Asn His Gly Leu Ala Val 
            20                  25                  30          


Pro Thr Pro Ser Val Pro Asp Asp Phe Ala Asp Lys Glu Val Thr Gly 
        35                  40                  45              


Thr Ser Ser Leu Val Asn Gly Asn Leu Arg Leu Tyr Ser Ser Val Ala 
    50                  55                  60                  


Pro Pro Pro Pro Pro Val Pro Ala Pro Ala Pro Pro Ala Pro Ala Ser 
65                  70                  75                  80  


Pro His Thr Val Gly Thr Arg Leu Phe Pro Pro Gly Gly Val Thr Lys 
                85                  90                  95      


Trp Lys Ser Asp Val Ala Leu Asn Gly Arg Gln Ala Glu Ala Thr Arg 
            100                 105                 110         


Ala Ser Pro Pro Arg Ser Pro Ala Glu Pro Lys Gly Ser Ala Leu Gly 
        115                 120                 125             


Pro Asn Pro Glu Pro His Leu Thr Phe Pro Arg Ser Phe Lys Val Pro 
    130                 135                 140                 


Pro Pro Thr Pro Val Arg Thr Ser Ser Ile Pro Val Gln Glu Ala Gln 
145                 150                 155                 160 


Glu Ala Pro Arg Lys Glu Glu Gly Ala Thr Lys Lys Ala Pro Ser Arg 
                165                 170                 175     


Leu Pro Leu Pro Pro Ser Phe His Ile Arg Pro Ala Ser Gln Val Tyr 
            180                 185                 190         


Pro Asp Arg Ala Pro Glu Pro Asp Cys Pro Gly Glu Leu Lys Ala Thr 
        195                 200                 205             


Ala Pro Ala Ser Pro Arg Leu Gly Gln Ser Gln Ser Gln Ala Asp Glu 
    210                 215                 220                 


Arg Ala Gly Thr Pro Pro Pro Ala Pro Pro Leu Pro Pro Pro Ala Pro 
225                 230                 235                 240 


Pro Leu Pro Pro Pro Ala Pro Pro Leu Pro Pro Ala Ala Pro Pro Leu 
                245                 250                 255     


Pro Cys Ala Gln Lys Ala Ala His Pro Pro Ala Gly Phe Thr Lys Thr 
            260                 265                 270         


Pro Lys Ser Ser Ser Pro Ala Leu Lys Pro Lys Pro Asn Pro Pro Ser 
        275                 280                 285             


Pro Glu Asn Thr Ala Ser Ser Ala Pro Val Asp Trp Arg Asp Pro Ser 
    290                 295                 300                 


Gln Met Glu Lys Leu Arg Asn Glu Leu Ala Ala Tyr Leu Cys Gly Ser 
305                 310                 315                 320 


Arg Arg Glu Asp Arg Phe Leu Ser His Arg Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Pro Gln Ser Lys Glu Gly Lys Lys Gly Pro Arg Leu Pro Glu Lys Glu 
            340                 345                 350         


Thr Leu Leu Ser Leu Pro Ala Lys Asp Thr Pro Pro Gly Val Pro Glu 
        355                 360                 365             


Lys Ser Leu Gly Gly Ser Ser Leu Thr Glu Thr Glu Ala Ala Pro Ser 
    370                 375                 380                 


Leu Thr Leu Pro Ser Val Asp Tyr Ile Pro Gln Asp Ser Pro Thr Pro 
385                 390                 395                 400 


Ser Val Arg Gln Ile Arg Asn Glu Leu Glu Ala Arg Leu Ser Ser Ala 
                405                 410                 415     


Ala Glu Lys Glu Ala Lys Pro Ser Ile Gly Ser Leu Pro Pro Lys Pro 
            420                 425                 430         


Arg Leu Glu Gly Gly Arg Ile Cys Glu Asn Gly Ala Asp Asp Asp Lys 
        435                 440                 445             


Leu Ser Lys Pro Val Ala Lys Asn Leu Pro Pro Gln Ser Thr Thr Leu 
    450                 455                 460                 


Leu Pro Thr Thr Ser Leu Gln Pro Lys Ala Met Leu Gly Pro Ala Ile 
465                 470                 475                 480 


Pro Pro Lys Ala Thr Pro Glu Pro Ala Ile Pro Pro Lys Ala Thr Leu 
                485                 490                 495     


Trp Pro Ala Thr Pro Pro Lys Ala Thr Leu Gly Pro Ala Thr Pro Leu 
            500                 505                 510         


Lys Ala Thr Ser Gly Pro Thr Thr Pro Leu Lys Ala Thr Ser Gly Pro 
        515                 520                 525             


Ala Ile Ala Ser Thr Ala Thr Thr Leu Pro Thr Thr Thr Ser Gln Leu 
    530                 535                 540                 


Met Ala Glu Lys Asp Ser Gly Pro Ala Gly Gln Pro Glu Lys Pro Ala 
545                 550                 555                 560 


Ser Gln Glu Val Ser Thr Pro Ser Gln Ala Arg Gly Glu Gly Ser Pro 
                565                 570                 575     


Ser Glu Ala Thr Arg Leu Pro Thr Gln Gly Ala Arg Ser Ser Ala Ala 
            580                 585                 590         


Phe Pro Pro Lys Thr Ser Pro Gly Gly Gly Glu Val Pro Cys Leu Tyr 
        595                 600                 605             


Lys Pro His Cys His Gln Ser Ser Leu Ser Arg Glu Val Ala Val Val 
    610                 615                 620                 


Met Pro Thr Leu Ala Arg Gly Gly Ala Ala Gly Pro Gly Glu Pro Val 
625                 630                 635                 640 


Glu Val Lys Glu Pro Pro Gly Leu Pro Ala Lys Pro Pro Ala Ser Ala 
                645                 650                 655     


Gln Pro Thr Asp Glu Leu Leu Arg His Pro Val Thr Gly Glu Val Val 
            660                 665                 670         


Glu Arg Gly Ser Pro Met Ala Leu Leu Leu Ala Ala Arg Gln Arg Ala 
        675                 680                 685             


Gln Lys Gly Arg Ser Val Gly Ala Ala Leu Gly Arg Ser Ser Leu Pro 
    690                 695                 700                 


Gly Ser Leu Arg Asp His Ser His Gln Ala Glu Ala Ser Ser Asp Ser 
705                 710                 715                 720 


Ile Phe His Ser Gln Gly Thr Pro Asn Ser Phe Thr Val Val Pro Lys 
                725                 730                 735     


Leu Pro Lys Glu Ala Glu Lys Asp Ser Pro Leu Thr Thr Glu Ile Pro 
            740                 745                 750         


Asn Lys Trp Gly Pro Arg Leu Gly Arg Asp Ala Glu Gly Thr Glu Leu 
        755                 760                 765             


Ser Arg Arg His Asn Trp Thr Lys Pro Glu Pro Gln Ala Pro Val Ala 
    770                 775                 780                 


Trp Glu Arg Val Ala Pro Ser Asn Leu Pro Gln Gly His Pro Leu Pro 
785                 790                 795                 800 


Lys Ser Phe Ser Ser Pro Pro Ser Pro Ser Asn Lys Arg Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Phe Asn Phe Glu Val Ile Pro Pro Pro Pro Glu Phe Ser 
            820                 825                 830         


Asn Asp Pro Glu Pro Pro Ala Pro Ala Leu Gln Tyr Leu Gly Arg Gln 
        835                 840                 845             


Ser Ser Pro Pro Arg Asn Asn Tyr Ser Asp Leu Arg Gln Leu Pro Asn 
    850                 855                 860                 


Ala Gly Pro Gly Ala Pro Pro Ala Leu Gly Phe Ser Arg Phe Pro Ala 
865                 870                 875                 880 


Gly Ala Arg Tyr Ala Gly Ala Gly Gly Leu Glu Arg Phe Ser Gly Gly 
                885                 890                 895     


Gly Arg Ser Leu Ile Lys Lys Arg Leu Tyr Val Gly Glu Pro His Arg 
            900                 905                 910         


Gly Pro Gly Leu Pro His Gly Gly Thr Gly Arg Ser Leu Ser Ser Pro 
        915                 920                 925             


Asn Cys Phe Gly Pro Gln Pro Gly Gly Pro Glu Met Arg Arg Val Asn 
    930                 935                 940                 


Ser Ala Gly Arg Ala Pro Pro Gly Gly Leu His Ala Pro Arg Leu Ser 
945                 950                 955                 960 


Leu Glu Gly Ala Ala Arg Gly Ala Ala Glu Ala Lys His Lys Ala Pro 
                965                 970                 975     


Gly Ser Ala Asp Tyr Gly Phe Ala Pro Ala Ala Gly Arg Ser Pro Tyr 
            980                 985                 990         


Thr Thr Thr Arg Tyr Gly Ser Pro  Ile Asn Thr Phe Thr  Val Arg Pro 
        995                 1000                 1005             


Gly Thr  Arg His Pro Ile Ser  Tyr Val Cys Ser Gly  Ala His Arg 
    1010                 1015                 1020             


Lys Ala  Thr Ser 
    1025         


<210>  767
<211>  1976
<212>  DNA
<213>  Homosapiens

<400>  767
cagaagttcc acctcaccat caagaaaggc cctggtccag gatgtgcaag gtgtgatgaa     60

atcacagggc tggggaaggt cagctcgggg tcacaagaag cctgatgggc aggaaagagc    120

atgaaagccc cagccagcct cacctgtgcg gctgggagga ctcacagaaa ccctctgtac    180

ccagtcatgg gccaaagaca ccgtcatgca agggggtgaa ggctccacac tcgtcccggc    240

cccgggcgtg gaagcaggac ctcgagcagt ctctggcagc agcctatgtg ccggtcgttg    300

tggactctaa ggggcagaat ccggacaagc tcagggtaca gtctcccctg gggctgcaag    360

gatttagtgg agactcttaa caccagttct ctggcatctg tgagtttgag tgtgggccat    420

catcttcttc cttctgctct ctccctctcc acatttcccg gtaccatctg atccatcagg    480

cccttctttg ctcaggcctg aaggactcag gcctgtgaga gaggacggcc ccgttgtcgg    540

ccaagacacc tttgggcgag gagcagcgaa cagggcctgt ccatctcaga cgtcagcccc    600

ctgaaggcct gagcaatggg caacgtgatg gagggaaagt cagtggagga gctgagcagc    660

accgagtgcc accagtggta caagaagttc atgactgagt gcccctctgg ccaactcacc    720

ctctatgagt tccgccagtt cttcggcctc aagaacctga gcccgtcggc cagccagtac    780

gtggaacaga tgtttgagac ttttgacttc aacaaggacg gctacattga tttcatggag    840

tacgtggcag cgctcagctt ggtcctcaag gggaaggtgg aacagaagct ccgctggtac    900

ttcaagctct atgatgtaga tggcaacggc tgcattgacc gcgatgagct gctcaccatc    960

atccaggcca ttcgcgccat taacccctgc agcgatacca ccatgactgc agaggagttc   1020

accgatacag tgttctccaa gattgacgtc aacggggatg gggaactctc cctggaagag   1080

tttatagagg gcgtccagaa ggaccagatg ctcctggaca cactgacacg aagcctggac   1140

cttacccgca tcgtgcgcag gctccagaat ggcgagcaag acgaggaggg ggctgacgag   1200

gccgctgagg cagccggctg agtgcaccgc ccggctgctt ctgcactagc gggtggggtg   1260

gtatggtggt gcctgttggt ggtgttcttg tcttaaccct agatagaatc taatgaactc   1320

agaggcttag ctcgcctctt tagggtccat ggtggcagca gagaggcaga agtgggagtc   1380

cagagccagg aacagtgaag gatggttcct ggcccctctg agtgacagct ggtggcagca   1440

ctccttgctg gggggcactg ttcaacatcc ctctgccgtc gggtgacccc ctagcccttc   1500

tgactcctct cccagctttt cccagctttc cccactgagc ttctccagtc catgctcttc   1560

tggacgtgga ctctctgagg cagaactgag cttttccagg cctcttatgg aatcctgcag   1620

atccagtggc tgcagcttca atcccagtgc tgcaatcaca catccattct gccctggggg   1680

accctggagc ctacttgtgc gctttgcatt tcattgattg acgcctccct tcaacaagca   1740

tttactgagc gcctactatg tactaatgct agatgttaga tgtacaaaga agacagtttt   1800

catcctctag gaactcatag gctaatggtg agacacacag acaaacatca ttataataaa   1860

atatgctaag agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       1976


<210>  768
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  768

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  769
<211>  2288
<212>  DNA
<213>  Homosapiens

<400>  769
agtcacccag gagatgatgg agaggctgat caggcctcct ggaaagggag gaagagggcc     60

ctagttggag agatccatca gcagaagcca gggaggagat acagaccctt gctccctgac    120

gctcctcagg gctagcatgg ggcaggagtt tagctgggag gaggcggagg cagctggcga    180

gatagatgtg gcggagctcc aggagtggta caagaagttt gtgatggagt gccccagcgg    240

cacactcttt atgcatgagt ttaagcgctt cttcaaggtc acagacgatg aggaggcctc    300

ccagtacgta gagggcatgt tccgagcctt cgacaagaat ggggacaaca ccatcgactt    360

cctggagtac gtggcagctc tgaatctcgt gctgaggggc accctggagc acaagctgaa    420

gcggacattc aagatctatg ataaggatgg caatggctgc atcgaccgcc tggagctact    480

caacattgtg gagggaattt accagctgaa gaaagcctgc cggcgagagc tacaaactga    540

gcaaggccag ctgctcacac ccgaggaggt cgtggacagg atcttcctcc tggtggatga    600

gaatggagat ggccagctgt ctctgaacgg gtttgttgaa ggtgcccgtc gggacaagtg    660

ggtgatgaag atgctgcaga tggacatgaa tcccagcagc tggctcgctc agcagagacg    720

gaaaagtgcc atgttctgag gagtctgggg cccctccacg actccaggct cacccaggtt    780

tccagggtag taggagggtc cctggctcag cctgctcatg cccactcttc ccctggtgtt    840

gacttcctgg caccccctgt gcagggctga gtggggatgg ggaagggctg ctgggtttga    900

agtggccaac agggcatagt ccattttgga ggagtccctg ggatggtgaa gggaattcag    960

ttacttttcc tgttcagccg ctcctgggag gactgtgcct tggctgggtg gttgtggggc   1020

tcccacagtt tctgggtgtt ctcagttgga agcaagagcc aactgagggg tgagggtccc   1080

acagaccaaa tcagaaatga gaacacaaag actggtagga ggcaggggtg ggagggtgtt   1140

gagactgaag aaaaggcagg agttgccggg cacggtggct cacgcctgta atcccagcac   1200

tttgggaggc cgaggcgggc agatcacgag gtcaggagat cgagaccatc ctggctaaca   1260

cggggtgaaa ccccgtctct actaaaaata caaaaaatca gccgggtgag gtggcgggcg   1320

cctgtagtcc cagctactca ggaggctgag gcaagagaat ggcgtgaacc ccagggggcc   1380

gagcctacag tgagccgaga ttgcgccact gcactccagc ctggacgaca gtgagactcc   1440

gtctcaaaaa aaaaaaaaag aaagaaaaga aaaggcagga gttttggggg gcagggggca   1500

gcaataattc tataacttcc gggatgctga ggggcgttca tggggaggac cctggcctcc   1560

tcctccccaa ggcatcctca ccagtggtgt caacaggaaa aatggcagca aatacgctgc   1620

aggctgtggt ctttctgcct ttgaaagggt cagctgtact taaagggact gtttcagctc   1680

tgcctgggtg ctgctctggg accccctgct gccaacccac cactccccca acaatcctct   1740

ctttccatcc atatccccca gtatggacct tccacaactc ccagccataa gctgaatgtt   1800

tctctttaaa ggatggagaa aacttctgtc tgtctctggc aagaattggg ggactgttga   1860

ctgggattgt gggctgggct tggcttctaa ctgctgtgtg acccaagaca gccacttctc   1920

ctccctaacc ttggttatgt cttggcagca cagtgagcag gtcggactag gcgaacagtt   1980

ttggattatt gtgtttttag atgtggaatt attttttgtt atataaactc ttatgtgtaa   2040

ccccaatata gaaactagat taaaagggag tctctctggt tgaaagggga gctgagtacc   2100

ctctggaact ggaggcacct ctgaaaaaag caaactgaaa accagtgccc tgggtcactg   2160

ttactcctat aagacagttt aaagtgagac ctggaaaaac atttgcttta ccttgaatag   2220

ataggttttt atgttggtat ataagaaata aaactaacct attaaacctg aaaaaaaaaa   2280

aaaaaaaa                                                            2288


<210>  770
<211>  200
<212>  PRT
<213>  Homosapiens

<400>  770

Met Gly Gln Glu Phe Ser Trp Glu Glu Ala Glu Ala Ala Gly Glu Ile 
1               5                   10                  15      


Asp Val Ala Glu Leu Gln Glu Trp Tyr Lys Lys Phe Val Met Glu Cys 
            20                  25                  30          


Pro Ser Gly Thr Leu Phe Met His Glu Phe Lys Arg Phe Phe Lys Val 
        35                  40                  45              


Thr Asp Asp Glu Glu Ala Ser Gln Tyr Val Glu Gly Met Phe Arg Ala 
    50                  55                  60                  


Phe Asp Lys Asn Gly Asp Asn Thr Ile Asp Phe Leu Glu Tyr Val Ala 
65                  70                  75                  80  


Ala Leu Asn Leu Val Leu Arg Gly Thr Leu Glu His Lys Leu Lys Arg 
                85                  90                  95      


Thr Phe Lys Ile Tyr Asp Lys Asp Gly Asn Gly Cys Ile Asp Arg Leu 
            100                 105                 110         


Glu Leu Leu Asn Ile Val Glu Gly Ile Tyr Gln Leu Lys Lys Ala Cys 
        115                 120                 125             


Arg Arg Glu Leu Gln Thr Glu Gln Gly Gln Leu Leu Thr Pro Glu Glu 
    130                 135                 140                 


Val Val Asp Arg Ile Phe Leu Leu Val Asp Glu Asn Gly Asp Gly Gln 
145                 150                 155                 160 


Leu Ser Leu Asn Gly Phe Val Glu Gly Ala Arg Arg Asp Lys Trp Val 
                165                 170                 175     


Met Lys Met Leu Gln Met Asp Met Asn Pro Ser Ser Trp Leu Ala Gln 
            180                 185                 190         


Gln Arg Arg Lys Ser Ala Met Phe 
        195                 200 


<210>  771
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  771
ccacaccgag caccagcttc tccgacgccg ggaagccgct gtcgccgccg ctacctctcc     60

ctgttgccgc cgcctcagat ctcttcatgc cgctgtaagc tcggaggcca aggatgcgga    120

gtaggcttcc cccagcgctt gccgccctgg gcgcggccct gctcctgtct tccattgagg    180

cagaagttga cccaccttca gacttgaatt ttaaaattat agatgaaaat actgttcata    240

tgtcatgggc aaaaccagtt gatccaattg tgggttacag aataacggtg gaccctacaa    300

cggatgggcc tactaaagaa tttacccttt cagctagtac cactgaaact ttattgtcag    360

aacttgtacc tgaaacagag tatgtggtga caataacttc atatgatgaa gtagaagaaa    420

gtgtaccagt tataggacaa ctaacaattc aaacaggtag ttcgacaaag ccagtggaga    480

agaaacctgg aaaaaccgag atacaaaaat gctctgtcag tgcctggact gatttggttt    540

tcctcgtgga tggctcttgg agtgtgggaa gaaataattt caagtacatt ttagacttca    600

ttgctgctct tgtgtctgct tttgacattg gggaagagaa gacaagagtt ggagttgttc    660

aatacagctc tgataccagg actgaattta acttaaatca gtactaccaa agggatgaac    720

ttcttgctgc aataaaaaaa attccatata aaggtggcaa cacaatgaca ggggatgcca    780

ttgattattt agttaaaaat actttcacgg aatctgctgg ggcaagagtt ggctttccta    840

aagtggcaat tattattacg gatggaaaat cccaggatga agtggaaatt ccagcaagag    900

agcttcgtaa tgttggagtt gaagttttct ccttgggcat taaagctgca gatgcaaaag    960

aactcaaaca aattgcctcc acaccttcac tgaaccatgt tttcaatgtg gccaactttg   1020

atgcaattgt ggatattcag aatgagatca tctcccaggt gtgctcaggt gttgatgaac   1080

aacttggtga attggttagt ggagaagaag ttgttgagcc tccttcaaat ttgattgcca   1140

tggaagtctc ttcaaaatat gttaagctaa attggaatcc atctcctagt ccagtgactg   1200

gctacaaagt catcctcaca ccaatgactg caggaagccg acagcacgct ctgagtgtgg   1260

ggcctcagac aaccacgctc agtgttcgcg acctctcagc agacacagaa taccagatca   1320

gtgtttccgc catgaaggga atgacatcca gtgaacccat ttcaataatg gagaagactc   1380

agccaatgaa agttcaagtg gaatgctcac gtggtgtgga tataaaagcc gatattgtgt   1440

ttttggttga tggctcctat agcattggga ttgcaaactt tgttaaagtt agagcctttt   1500

tggaagttct tgtaaaaagt tttgaaattt caccaaatag ggtccagatt agtcttgtgc   1560

aatacagccg ggatcctcat actgagttca ctttgaaaaa attcaccaaa gttgaagata   1620

taattgaagc aataaacacc ttcccttaca gaggaggatc tacaaatact ggcaaagcaa   1680

tgacttatgt cagagagaaa atatttgtgc ctagcaaggg atcaagaagc aatgtgccaa   1740

aggtcatgat tcttatcacg gatgggaaat catcagatgc tttcagagat cctgcgataa   1800

aactgaggaa ttcagatgtt gaaatctttg cagttggtgt gaaggatgcc gttcgctcag   1860

aattggaagc tattgcctct cctcctgcag agacccatgt gttcacagtg gaagattttg   1920

atgcttttca gaggatatct tttgaactca cacagtctat ctgccttaga attgagcaag   1980

aattggcagc tataaagaag aaagcttacg tccctccaaa ggatcttagt ttttcagaag   2040

tgacttctta tggtttcaaa accaactggt ctccagctgg agaaaatgtt ttttcatatc   2100

acatcaccta caaggaagcg gctggggatg atgaggtcac tgtggtggag ccagcatcga   2160

gcaccagtgt tgttctcagc agcctgaagc cagagacctt gtatttggtc aatgtgactg   2220

cggagtatga ggatggcttc agcattccct tagctggaga ggagaccacc gaagaagtaa   2280

aaggagcacc tcgaaaccta aaggtgacag atgagactac agatagtttc aaaattactt   2340

ggactcaagc tccagggaga gttttaagat atcgaattat atatagacca gttgctggtg   2400

gagagagcag agaagttacc accccaccca atcagaggag gagaacactg gagaacttga   2460

ttccagacac gaaatatgaa gtatctgtaa ttcctgaata tttctcagga cctggtactc   2520

cattaactgg aaatgcagcc actgaagaag ttagagggaa tccaagagac ttaagagttt   2580

ctgaccctac gacgtctact atgaaattat cttggagtgg ggcaccagga aaagtgaaac   2640

agtatctcgt cacatatacc ccagtggcag ggggtgaaac tcaagaggtc actgtgaggg   2700

gagatacaac caatacggtg ctgcagggat tgaaggaagg gacacaatac gccttatctg   2760

tgacagcctt gtatgcgtct ggggctggag acgccctctt tggtgaagga acaacacttg   2820

aagaacgtgg ttctcctcaa gatttagtta ctaaagacat cactgacaca tcaattgggg   2880

cttattggac atctgctcca ggaatggttc gcggttacag ggtctcatgg aaatcacttt   2940

atgatgatgt tgacactgga gagaaaaatc tgcctgaaga tgcaattcat acgatgatag   3000

aaaatctgca gccagagacc aaatacagaa tttcagtatt tgccacttac agcagtggag   3060

aaggagaacc tttgactgga gatgccacaa ctgaattatc tcaagattcc aaaaccctga   3120

aagtagatga agaaacagaa aacacaatga gagttacatg gaaaccagca ccagggaaag   3180

tcgtcaacta ccgtgttgtc tatcgccctc atgggagagg gaagcaaatg gttgctaagg   3240

tgccccccac agtcacttcg acagtgttaa agcgacttca gccacagacc acatatgaca   3300

tcacagttct tcctatttac aagatgggag aaggaaagct taggcaagga tcaggaacaa   3360

cagcttctcg gtttaagtct cctagaaacc tcaaaacatc tgacccaacc atgtcaagct   3420

tccgagtgac ttgggagcct gcccctgggg aagtgaaggg ttataaagtc acattccacc   3480

ctacggggga tgacagaaga ctgggggagt tagtggttgg accctatgac aacacagttg   3540

ttttggagga acttagggct ggtaccacct ataaagtaaa tgtttttgga atgtttgatg   3600

gaggagaaag ctcaccactt gttggacaag aaatgacaac cctttccgac acaactgtta   3660

tgccaatttt atcttctggg atggagtgtc tcaccagagc tgaggcagac attgtgttgc   3720

tggtggatgg atcatggagc atcggccggg caaattttag aaccgtgagg agtttcattt   3780

ctcgtattgt ggaagtcttt gacattggcc ccaaaagagt acaaattgct cttgctcagt   3840

atagtgggga tcccagaaca gagtggcagt taaatgcaca cagagacaag aagagcttgt   3900

tgcaagctgt ggcaaacttg ccgtacaaag gaggcaatac tctcacaggc atggctttga   3960

atttcattcg ccaacagaac ttcaggaccc aagctggcat gagacctcga gctcgaaaaa   4020

ttggtgtgct cattactgat ggaaaatcac aagacgatgt tgaagcacct tcaaagaaac   4080

tcaaggatga gggagtggag ctgtttgcta ttggtattaa aaatgctgat gaagtcgaat   4140

taaagatgat tgcaactgat cctgatgata cccatgcata caatgtggca gattttgagt   4200

cactctccag gatagtggat gatctcacca ttaatttgtg taacagtgtc aaaggtccag   4260

gtgatttgga agcaccttct aacttagtta tttctgagcg aacccatcgt tcttttagag   4320

tgagctggac accaccttct gacagtgtgg atcgatataa ggtggaatac tatccagttt   4380

ctggagggaa acgtcaagaa ttttatgtga gtcgaatgga aactagcaca gtgctgaaag   4440

atctgaaacc tgaaactgaa tatgttgtca atgtgtattc tgtggtagaa gatgaatata   4500

gtgagcctct gaaggggaca gaaaaaacct tgccagtgcc tgtagtcagc ctgaatattt   4560

atgatgttgg ccctaccacc atgcatgtgc agtggcagcc tgtgggagga gctactggct   4620

acatcttgtc atacaaacct gttaaggaca cagagccaac aagacccaaa gaggtgcgtt   4680

tggggccaac agtgaatgac atgcagctga ctgaccttgt tcccaacacg gagtatgcag   4740

tcacagtcca ggctgtcctg cacgacctca ctagtgaacc tgtcactgtt cgggaagtca   4800

ccttgccttt acccagacct caggatctga aactcagaga tgtgactcac agcactatga   4860

atgtcttttg ggaacctgtg cctggaaaag tgcgtaaata tattgttcga tacaaaacac   4920

cagaagagga tgtcaaagag gtagaggtgg acagatcaga gaccagcact tccctcaaag   4980

acctcttctc acagaccttg tacacagtca gcgtttctgc agtacatgac gagggggagt   5040

ctcctccagt gactgctcaa gaaactaccc gacccgtgcc agccccaaca aacttaaaga   5100

ttactgaagt aacatcagag ggtttcagag ggacttggga tcatggagct tcagatgtgt   5160

ctctctacag aataacttgg gcaccttttg gaagctcaga taagatggag accatcttaa   5220

atggagatga aaacactttg gtgttcgaaa acctgaaccc caacaccatc tatgaagttt   5280

ccattactgc catctatcct gatgagtcag aaagtgatga cctgattggc agtgagcgca   5340

ctctgcctat cttaacaaca caagctccca aaagtggccc acgaaacctt caagtgtaca   5400

atgcaacatc taacagcctg actgttaagt gggatcctgc tagtggtcgt gtgcagaaat   5460

ataggatcac ttatcagcct tccacagggg aaggcaatga gcaaacgacc acaataggag   5520

gacggcagaa cagtgtggtc ctgcagaaac tgaagccaga cactccttac actatcaccg   5580

tatcctctct gtatcctgat ggtgaaggag gtcggatgac gggaagaggc aagaccaaac   5640

ctctaaacac tgtaaggaac ctgagagtgt atgacccttc taccagcacc ttgaatgtcc   5700

gctgggacca tgcagaggga aatcctcgtc agtacaagct cttctatgca ccagcagcag   5760

gtggtccaga ggaactggta ccaatccccg ggaataccaa ttatgccatt cttaggaatc   5820

tgcagccaga tacctcatac actgtgactg tagttcccgt ttatactgaa ggtgatgggg   5880

gacgcacatc agatactgga aggacattga tgagaggact ggcaagaaat gtccaagtat   5940

acaatcctac acctaacagc ctcgatgttc gctgggaccc tgctccagga cctgtgctgc   6000

aatatcgcgt tgtgtattct cctgtggatg gcacaagacc ctcagaatct atagtagtgc   6060

caggaaacac gcgcatggtg catctggagc ggctgattcc ggacacactc tattccgtga   6120

accttgtggc tctgtactcg gatggagagg gaaatcccag ccctgcccag ggccgaacgc   6180

taccacgcag tggaccaagg aacctgagag tctttggtga aacaaccaat agcctctcgg   6240

tagcctggga tcatgctgat gggccagttc agcagtacag gatcatctat tctcccactg   6300

ttggtgatcc aattgatgaa tataccacag tcccaggcag aagaaacaat gtaatactgc   6360

agcccctgca acctgacact ccatataaaa ttactgttat tgctgtttat gaagatggag   6420

atggtggcca tctaacagga aatggaagaa ctgtgggact ccttcctcct cagaacatac   6480

acatctctga cgaatggtat acaagattca gggtgtcctg ggatccttca ccttctccag   6540

ttcttggata taaaatagta tataagccag tgggttccaa tgagcccatg gaagcctttg   6600

ttggagaaat gacatcatat accttacaca atctcaatcc cagcaccacc tacgatgtga   6660

atgtttatgc tcaatatgat tctggactca gtgtcccctt gacagatcaa ggcactacat   6720

tatatttaaa tgtaacagat ctgaaaactt accagattgg gtgggataca ttctgtgtca   6780

aatggtcacc tcaccgggca gccacctcct acaggctaaa actaagccct gcagatggaa   6840

caaggggaca agaaattaca gtgcgtggat cagaaaccag tcactgcttc actggccttt   6900

caccagacac tgattatggt gtcactgttt ttgtgcagac accaaatctc gagggaccag   6960

gagtctctgt taaagaacat accactgtga aaccaacaga agcccctaca gagccaccca   7020

cacctcctcc ccctcccacc attccaccag cccgggatgt atgcaaaggg gccaaggcag   7080

atattgtgtt cttgactgat gcctcctgga gcattgggga cgataatttt aacaaagttg   7140

taaaattcat cttcaatact gtgggaggct ttgatgaaat cagtcctgct gggattcagg   7200

tttcatttgt gcaatacagc gatgaggtca agtctgagtt caagctgaac acgtacaatg   7260

acaaggccct agcccttggg gccctccaga atattaggta cagaggagga aacacaagaa   7320

caggcaaggc cctcacgttt atcaaggaga aagtcttgac ttgggagagc ggcatgagga   7380

agaatgtccc taaggtgttg gttgtggtca cggacggtcg gtcccaggat gaggtcaaga   7440

aggcggcttt ggtcatccag cagtcagggt tcagtgtctt tgtagttggt gtggctgatg   7500

tcgactacaa tgagcttgcc aacattgcca gcaaaccaag tgaacggcac gtgttcattg   7560

tggacgactt tgaatctttt gagaagatcg aagacaatct tattacattt gtttgtgaaa   7620

ctgccacttc aagttgtcct ctcatttatt tggatggcta cacctcacca ggttttaaaa   7680

tgcttgaagc atacaacctg acagaaaaga attttgcttc tgtacaagga gtatctttgg   7740

agtcagggtc tttccccagc tactcagcat acaggattca gaagaatgcg tttgtgaatc   7800

agcctacagc agacctacac ccaaatggac tccctccttc atacacgatt atattattat   7860

tcagacttct cccagaaact cccagtgacc cttttgcaat ttggcaaatc acagacagag   7920

actacaaacc acaagttgga gtgattgcag atccttctag caagacgtta tcattcttta   7980

acaaggatac aagaggcgag gtgcaaactg ttacatttga cacagaagaa gtaaagacat   8040

tattttatgg aagttttcac aaggttcata ttgtagtgac ctcaaaaagt gttaagattt   8100

acattgactg ctatgaaatt atagaaaaag acatcaagga agctggaaat ataacaactg   8160

atggttatga aattcttgga aaactcctta aa                                 8192


<210>  772
<211>  3063
<212>  PRT
<213>  Homosapiens

<400>  772

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Ser Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Arg Pro Gly  Ser Pro Gly Ser Pro  Gly Val Thr 
    2855                 2860                 2865             


Gly Pro  Ser Gly Lys Pro Gly  Lys Pro Gly Asp His  Gly Arg Pro 
    2870                 2875                 2880             


Gly Pro  Ser Gly Leu Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ile 
    2885                 2890                 2895             


Ala Ser  Gln Asn Met Met Arg  Ala Val Ala Arg Gln  Val Cys Glu 
    2900                 2905                 2910             


Gln Leu  Ile Ser Gly Gln Met  Asn Arg Phe Asn Gln  Met Leu Asn 
    2915                 2920                 2925             


Gln Ile  Pro Asn Asp Tyr Gln  Ser Ser Arg Asn Gln  Pro Gly Pro 
    2930                 2935                 2940             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ser Ala Gly Ala  Arg Gly Glu 
    2945                 2950                 2955             


Pro Gly  Pro Gly Gly Arg Pro  Gly Phe Pro Gly Thr  Pro Gly Met 
    2960                 2965                 2970             


Gln Gly  Pro Pro Gly Glu Arg  Gly Leu Pro Gly Glu  Lys Gly Glu 
    2975                 2980                 2985             


Arg Gly  Thr Gly Ser Ser Gly  Pro Arg Gly Leu Pro  Gly Pro Pro 
    2990                 2995                 3000             


Gly Pro  Gln Gly Glu Ser Arg  Thr Gly Pro Pro Gly  Ser Thr Gly 
    3005                 3010                 3015             


Ser Arg  Gly Pro Pro Gly Pro  Pro Gly Arg Pro Gly  Asn Ser Gly 
    3020                 3025                 3030             


Ile Gln  Gly Pro Pro Gly Pro  Pro Gly Tyr Cys Asp  Ser Ser Gln 
    3035                 3040                 3045             


Cys Ala  Ser Ile Pro Tyr Asn  Gly Gln Ser Tyr Pro  Gly Ser Gly 
    3050                 3055                 3060             


<210>  773
<211>  8062
<212>  DNA
<213>  Homosapiens

<400>  773
ccacaccgag caccagcttc tccgacgccg ggaagccgct gtcgccgccg ctacctctcc     60

ctgttgccgc cgcctcagat ctcttcatgc cgctgtaagc tcggaggcca aggatgcgga    120

gtaggcttcc cccagcgctt gccgccctgg gcgcggccct gctcctgtct tccattgagg    180

cagaagggat ggagtgtctc accagagctg aggcagacat tgtgttgctg gtggatggat    240

catggagcat cggccgggca aattttagaa ccgtgaggag tttcatttct cgtattgtgg    300

aagtctttga cattggcccc aaaagagtac aaattgctct tgctcagtat agtggggatc    360

ccagaacaga gtggcagtta aatgcacaca gagacaagaa gagcttgttg caagctgtgg    420

caaacttgcc gtacaaagga ggcaatactc tcacaggcat ggctttgaat ttcattcgcc    480

aacagaactt caggacccaa gctggcatga gacctcgagc tcgaaaaatt ggtgtgctca    540

ttactgatgg aaaatcacaa gacgatgttg aagcaccttc aaagaaactc aaggatgagg    600

gagtggagct gtttgctatt ggtattaaaa atgctgatga agtcgaatta aagatgattg    660

caactgatcc tgatgatacc catgcataca atgtggcaga ttttgagtca ctctccagga    720

tagtggatga tctcaccatt aatttgtgta acagtgtcaa aggtccaggt gatttggaag    780

caccttctaa cttagttatt tctgagcgaa cccatcgttc ttttagagtg agctggacac    840

caccttctga cagtgtggat cgatataagg tggaatacta tccagtttct ggagggaaac    900

gtcaagaatt ttatgtgagt cgaatggaaa ctagcacagt gctgaaagat ctgaaacctg    960

aaactgaata tgttgtcaat gtgtattctg tggtagaaga tgaatatagt gagcctctga   1020

aggggacaga aaaaaccttg ccagtgcctg tagtcagcct gaatatttat gatgttggcc   1080

ctaccaccat gcatgtgcag tggcagcctg tgggaggagc tactggctac atcttgtcat   1140

acaaacctgt taaggacaca gagccaacaa gacccaaaga ggtgcgtttg gggccaacag   1200

tgaatgacat gcagctgact gaccttgttc ccaacacgga gtatgcagtc acagtccagg   1260

ctgtcctgca cgacctcact agtgaacctg tcactgttcg ggaagtcacc ttgcctttac   1320

ccagacctca ggatctgaaa ctcagagatg tgactcacag cactatgaat gtcttttggg   1380

aacctgtgcc tggaaaagtg cgtaaatata ttgttcgata caaaacacca gaagaggatg   1440

tcaaagaggt agaggtggac agatcagaga ccagcacttc cctcaaagac ctcttctcac   1500

agaccttgta cacagtcagc gtttctgcag tacatgacga gggggagtct cctccagtga   1560

ctgctcaaga aactacccga cccgtgccag ccccaacaaa cttaaagatt actgaagtaa   1620

catcagaggg tttcagaggg acttgggatc atggagcttc agatgtgtct ctctacagaa   1680

taacttgggc accttttgga agctcagata agatggagac catcttaaat ggagatgaaa   1740

acactttggt gttcgaaaac ctgaacccca acaccatcta tgaagtttcc attactgcca   1800

tctatcctga tgagtcagaa agtgatgacc tgattggcag tgagcgcact ctgcctatct   1860

taacaacaca agctcccaaa agtggcccac gaaaccttca agtgtacaat gcaacatcta   1920

acagcctgac tgttaagtgg gatcctgcta gtggtcgtgt gcagaaatat aggatcactt   1980

atcagccttc cacaggggaa ggcaatgagc aaacgaccac aataggagga cggcagaaca   2040

gtgtggtcct gcagaaactg aagccagaca ctccttacac tatcaccgta tcctctctgt   2100

atcctgatgg tgaaggaggt cggatgacgg gaagaggcaa gaccaaacct ctaaacactg   2160

taaggaacct gagagtgtat gacccttcta ccagcacctt gaatgtccgc tgggaccatg   2220

cagagggaaa tcctcgtcag tacaagctct tctatgcacc agcagcaggt ggtccagagg   2280

aactggtacc aatccccggg aataccaatt atgccattct taggaatctg cagccagata   2340

cctcatacac tgtgactgta gttcccgttt atactgaagg tgatggggga cgcacatcag   2400

atactggaag gacattgatg agaggactgg caagaaatgt ccaagtatac aatcctacac   2460

ctaacagcct cgatgttcgc tgggaccctg ctccaggacc tgtgctgcaa tatcgcgttg   2520

tgtattctcc tgtggatggc acaagaccct cagaatctat agtagtgcca ggaaacacgc   2580

gcatggtgca tctggagcgg ctgattccgg acacactcta ttccgtgaac cttgtggctc   2640

tgtactcgga tggagaggga aatcccagcc ctgcccaggg ccgaacgcta ccacgcagtg   2700

gaccaaggaa cctgagagtc tttggtgaaa caaccaatag cctctcggta gcctgggatc   2760

atgctgatgg gccagttcag cagtacagga tcatctattc tcccactgtt ggtgatccaa   2820

ttgatgaata taccacagtc ccaggcagaa gaaacaatgt aatactgcag cccctgcaac   2880

ctgacactcc atataaaatt actgttattg ctgtttatga agatggagat ggtggccatc   2940

taacaggaaa tggaagaact gtgggactcc ttcctcctca gaacatacac atctctgacg   3000

aatggtatac aagattcagg gtgtcctggg atccttcacc ttctccagtt cttggatata   3060

aaatagtata taagccagtg ggttccaatg agcccatgga agcctttgtt ggagaaatga   3120

catcatatac cttacacaat ctcaatccca gcaccaccta cgatgtgaat gtttatgctc   3180

aatatgattc tggactcagt gtccccttga cagatcaagg cactacatta tatttaaatg   3240

taacagatct gaaaacttac cagattgggt gggatacatt ctgtgtcaaa tggtcacctc   3300

accgggcagc cacctcctac aggctaaaac taagccctgc agatggaaca aggggacaag   3360

aaattacagt gcgtggatca gaaaccagtc actgcttcac tggcctttca ccagacactg   3420

attatggtgt cactgttttt gtgcagacac caaatctcga gggaccagga gtctctgtta   3480

aagaacatac cactgtgaaa ccaacagaag cccctacaga gccacccaca cctcctcccc   3540

ctcccaccat tccaccagcc cgggatgtat gcaaaggggc caaggcagat attgtgttct   3600

tgactgatgc ctcctggagc attggggacg ataattttaa caaagttgta aaattcatct   3660

tcaatactgt gggaggcttt gatgaaatca gtcctgctgg gattcaggtt tcatttgtgc   3720

aatacagcga tgaggtcaag tctgagttca agctgaacac gtacaatgac aaggccctag   3780

cccttggggc cctccagaat attaggtaca gaggaggaaa cacaagaaca ggcaaggccc   3840

tcacgtttat caaggagaaa gtcttgactt gggagagcgg catgaggaag aatgtcccta   3900

aggtgttggt tgtggtcacg gacggtcggt cccaggatga ggtcaagaag gcggctttgg   3960

tcatccagca gtcagggttc agtgtctttg tagttggtgt ggctgatgtc gactacaatg   4020

agcttgccaa cattgccagc aaaccaagtg aacggcacgt gttcattgtg gacgactttg   4080

aatcttttga gaagatcgaa gacaatctta ttacatttgt ttgtgaaact gccacttcaa   4140

gttgtcctct catttatttg gatggctaca cctcaccagg ttttaaaatg cttgaagcat   4200

acaacctgac agaaaagaat tttgcttctg tacaaggagt atctttggag tcagggtctt   4260

tccccagcta ctcagcatac aggattcaga agaatgcgtt tgtgaatcag cctacagcag   4320

acctacaccc aaatggactc cctccttcat acacgattat attattattc agacttctcc   4380

cagaaactcc cagtgaccct tttgcaattt ggcaaatcac agacagagac tacaaaccac   4440

aagttggagt gattgcagat ccttctagca agacgttatc attctttaac aaggatacaa   4500

gaggcgaggt gcaaactgtt acatttgaca cagaagaagt aaagacatta ttttatggaa   4560

gttttcacaa ggttcatatt gtagtgacct caaaaagtgt taagatttac attgactgct   4620

atgaaattat agaaaaagac atcaaggaag ctggaaatat aacaactgat ggttatgaaa   4680

ttcttggaaa actccttaaa ggggaaagga aatcagccgc attccaaatc cagagttttg   4740

acattgtctg cagtccagtg tggaccagta gagacagatg ctgtgatatt ccctctagga   4800

gagatgaggg aaaatgccct gcttttccaa attcttgcac atgtacacag gacagcgttg   4860

gacctccagg acctccaggc cctgcaggag gacctggtgc taaaggtccc agaggtgaaa   4920

gaggtatcag tggggcaatt gggccccctg gtcctcgtgg agacataggt cctccaggcc   4980

cccagggtcc tccaggccct cagggaccca atggactctc tattccggga gagcaaggtc   5040

gccaagggat gaaaggtgat gctggagagc caggacttcc aggccgaaca ggaaccccag   5100

gattacctgg cccaccagga ccaatgggac ctccaggaga cagaggcttc actggaaaag   5160

acagtgcaat gggacccagg ggcccaccag ggcggccggg aagcccaggc tccccaggag   5220

tcacaggacc aagtgggaag ccaggaaaac ctggagatca tggcagacca ggtccatctg   5280

ggttgaaagg agaaaaaggt gataggggag acattgcttc ccagaacatg atgcgagcag   5340

ttgcaagaca agtctgtgaa caattgataa gtggtcagat gaacagattc aatcagatgc   5400

tgaatcagat tccaaatgat taccagtcca gtcgcaacca gccaggcccg ccgggtccac   5460

cgggacctcc tggtagcgca ggagccagag gagaacctgg gcctgggggg cggccaggct   5520

tcccgggcac accagggatg cagggacccc ctggggaacg aggtttgcca ggagagaaag   5580

gtgaaagggg tactggatct tcaggacctc gggggctgcc tgggccccca ggtccacaag   5640

gagaatccag aacaggtcca ccagggtcca caggttcaag aggtccccct ggcccccctg   5700

gccgtcctgg aaactcaggt atccagggcc ccccaggtcc tcctggatac tgtgattctt   5760

ctcagtgtgc cagcatccca tacaacgggc aaagctatcc aggttccggc taacacattt   5820

tctaagtcgc cagtgctgct tacagtttga atacatgaaa atcctgtttc tgagatgttt   5880

gcgcacgtgc ttattaggaa atgagtctgt atggaaatct caccacagat aatggttaac   5940

gaaccgggtc gacatcacaa aggagggtgg agactctttt tactaacttg aatgagacaa   6000

aagcagtggt gtcagtttat aatcctgatg catttcagta ataatgtaga aaaacattat   6060

tttaaaaaag ttccaacaca cagccatgag gagccatgag gagcctcagt tttgaaagag   6120

gtgcataata aaactactaa ccagaggagt ctatgccatt ttaagaaaaa caattaacct   6180

ggttaaagag aaatgtctta tgtaaataat aaactaattg tggcttgtaa atgatttgta   6240

tgtgatcctg tcgactaaaa tcacttaaca attctacaat aagcttctgc atcaaagcct   6300

gccgcttgct ctatgccgga ataacaccaa atggaatctc ctcatctctt gcttgttagc   6360

gatgtgtctg attcagggca tctgtctttt tgttactttt ttgtccgtgt cctctcattt   6420

gggttttgta actgcaattt tcaaaccaaa gtttaaaatc accttttctt cctgttttgc   6480

tgtagtcact ggtgttcctc acccaccagc tgtaactcag tttgtgtgag gtacagccac   6540

agaagatgtc atgtactgta tattacctgg tgatagttgc ttttcacccc ccgagttcag   6600

tttctaggag ccaatgaaac ttcccctcac ctcctcatct ttccaagttg ttctttgaat   6660

tgaggagttt gaaggcataa acagttactt ggggatttgc gaaaatccta cttagttact   6720

gcgtttacag ttctttggcc cagtctctga cccttcccaa gtatttgtgc aatgattgtg   6780

tttactgctg gatttttgaa ggtttttttt tttaagaaag tgccatttca ttatttgatt   6840

atcaccaaat tatctggaaa taattgggac attgtaactt atctatttat agttatgaga   6900

ttaagactgg agtgccatca ccgcgggtga tgatttagct tttgctgtgt gtgtgtgtgt   6960

gtgtgtgcct tccaaatcat gccataattg taatgttgaa tcggacagag ccttacgtgc   7020

ccgagggcgg ggcctacctg cctgagcgcg agcccttcat cgtgccggtg gagcccgagc   7080

ggacagcgga atacgaggac tacggcgcag acgagcctgc agaggagcct cctgagcccc   7140

accggcgctg gcggcgcgcc ctgccccacg gacccgggca gtgaaccaga gatcacgcgc   7200

cgcgccgcga ggcttggggg aggtgttgaa attctcattt acaggtcaga tagagcagtg   7260

tacgtctttt ctgaggtgtt tcttccagcg ttgctcatcc aggagtaccc tttctgattg   7320

tagagaacct tgtttctgca ggaagcctag ctccaagcac gcagtctgta gacatttttg   7380

cctttgccct tgaaatgctt gcaaaatact ttgttaacaa aagctgcaaa gagagaacat   7440

gccgtgtgcc tttagttagc acagcgggca gcctcagtga aactcttagg ttaagcagtt   7500

aagtcctgga acccagagct gctgtgtatt tcgagcgggc agtttatctt ttgctatact   7560

tattttcaat tcaattacac cacgattcaa ataattcccc tcctaaaacc aaaaaggagg   7620

gaaacgtcaa ctccattgca attacttatc ttcctcttct atctctgtta tacgccgggg   7680

catagaatgc tcgtatacat ctctttaaca accacaaacc ttaagccatg tagatgaagt   7740

tagtgcatca acgggataca gttccatatt gccttaaacc tccttgtttt agacacacta   7800

acatttatac caaattgcag attattctgc agagagggaa ttgcatgttt gtgttgtata   7860

tttagtatga acttttttca gaatataata tttcttagtt atcaaaagta gttggaaaac   7920

atttgcaaga ctatgaacat agaattgctg cttttatatt ttaactgcag attgtgaatt   7980

tcactgcctt atattattta tttctgaaac aaaagaggca tttttcaata aaactactga   8040

aaatttgaaa aaaaaaaaaa aa                                            8062


<210>  774
<211>  1899
<212>  PRT
<213>  Homosapiens

<400>  774

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Gly Met Glu Cys Leu Thr Arg Ala 
            20                  25                  30          


Glu Ala Asp Ile Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg 
        35                  40                  45              


Ala Asn Phe Arg Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val 
    50                  55                  60                  


Phe Asp Ile Gly Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser 
65                  70                  75                  80  


Gly Asp Pro Arg Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys 
                85                  90                  95      


Ser Leu Leu Gln Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr 
            100                 105                 110         


Leu Thr Gly Met Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr 
        115                 120                 125             


Gln Ala Gly Met Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr 
    130                 135                 140                 


Asp Gly Lys Ser Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys 
145                 150                 155                 160 


Asp Glu Gly Val Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu 
                165                 170                 175     


Val Glu Leu Lys Met Ile Ala Thr Asp Pro Asp Asp Thr His Ala Tyr 
            180                 185                 190         


Asn Val Ala Asp Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr 
        195                 200                 205             


Ile Asn Leu Cys Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro 
    210                 215                 220                 


Ser Asn Leu Val Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser 
225                 230                 235                 240 


Trp Thr Pro Pro Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr 
                245                 250                 255     


Pro Val Ser Gly Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu 
            260                 265                 270         


Thr Ser Thr Val Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val 
        275                 280                 285             


Asn Val Tyr Ser Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly 
    290                 295                 300                 


Thr Glu Lys Thr Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp 
305                 310                 315                 320 


Val Gly Pro Thr Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala 
                325                 330                 335     


Thr Gly Tyr Ile Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr 
            340                 345                 350         


Arg Pro Lys Glu Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu 
        355                 360                 365             


Thr Asp Leu Val Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val 
    370                 375                 380                 


Leu His Asp Leu Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu 
385                 390                 395                 400 


Pro Leu Pro Arg Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser 
                405                 410                 415     


Thr Met Asn Val Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr 
            420                 425                 430         


Ile Val Arg Tyr Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val 
        435                 440                 445             


Asp Arg Ser Glu Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr 
    450                 455                 460                 


Leu Tyr Thr Val Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro 
465                 470                 475                 480 


Pro Val Thr Ala Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn 
                485                 490                 495     


Leu Lys Ile Thr Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp 
            500                 505                 510         


His Gly Ala Ser Asp Val Ser Leu Tyr Arg Ile Thr Trp Ala Pro Phe 
        515                 520                 525             


Gly Ser Ser Asp Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr 
    530                 535                 540                 


Leu Val Phe Glu Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile 
545                 550                 555                 560 


Thr Ala Ile Tyr Pro Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser 
                565                 570                 575     


Glu Arg Thr Leu Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro 
            580                 585                 590         


Arg Asn Leu Gln Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys 
        595                 600                 605             


Trp Asp Pro Ala Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln 
    610                 615                 620                 


Pro Ser Thr Gly Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg 
625                 630                 635                 640 


Gln Asn Ser Val Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr 
                645                 650                 655     


Ile Thr Val Ser Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr 
            660                 665                 670         


Gly Arg Gly Lys Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val 
        675                 680                 685             


Tyr Asp Pro Ser Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu 
    690                 695                 700                 


Gly Asn Pro Arg Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly 
705                 710                 715                 720 


Pro Glu Glu Leu Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu 
                725                 730                 735     


Arg Asn Leu Gln Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val 
            740                 745                 750         


Tyr Thr Glu Gly Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu 
        755                 760                 765             


Met Arg Gly Leu Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn 
    770                 775                 780                 


Ser Leu Asp Val Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr 
785                 790                 795                 800 


Arg Val Val Tyr Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile 
                805                 810                 815     


Val Val Pro Gly Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro 
            820                 825                 830         


Asp Thr Leu Tyr Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu 
        835                 840                 845             


Gly Asn Pro Ser Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro 
    850                 855                 860                 


Arg Asn Leu Arg Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala 
865                 870                 875                 880 


Trp Asp His Ala Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser 
                885                 890                 895     


Pro Thr Val Gly Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg 
            900                 905                 910         


Arg Asn Asn Val Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys 
        915                 920                 925             


Ile Thr Val Ile Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr 
    930                 935                 940                 


Gly Asn Gly Arg Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile 
945                 950                 955                 960 


Ser Asp Glu Trp Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro 
                965                 970                 975     


Ser Pro Val Leu Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn 
            980                 985                 990         


Glu Pro Met Glu Ala Phe Val Gly  Glu Met Thr Ser Tyr  Thr Leu His 
        995                 1000                 1005             


Asn Leu  Asn Pro Ser Thr Thr  Tyr Asp Val Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Tyr Asp  Ser Gly Leu Ser Val  Pro Leu Thr Asp Gln  Gly Thr Thr 
    1025                 1030                 1035             


Leu Tyr  Leu Asn Val Thr Asp  Leu Lys Thr Tyr Gln  Ile Gly Trp 
    1040                 1045                 1050             


Asp Thr  Phe Cys Val Lys Trp  Ser Pro His Arg Ala  Ala Thr Ser 
    1055                 1060                 1065             


Tyr Arg  Leu Lys Leu Ser Pro  Ala Asp Gly Thr Arg  Gly Gln Glu 
    1070                 1075                 1080             


Ile Thr  Val Arg Gly Ser Glu  Thr Ser His Cys Phe  Thr Gly Leu 
    1085                 1090                 1095             


Ser Pro  Asp Thr Asp Tyr Gly  Val Thr Val Phe Val  Gln Thr Pro 
    1100                 1105                 1110             


Asn Leu  Glu Gly Pro Gly Val  Ser Val Lys Glu His  Thr Thr Val 
    1115                 1120                 1125             


Lys Pro  Thr Glu Ala Pro Thr  Glu Pro Pro Thr Pro  Pro Pro Pro 
    1130                 1135                 1140             


Pro Thr  Ile Pro Pro Ala Arg  Asp Val Cys Lys Gly  Ala Lys Ala 
    1145                 1150                 1155             


Asp Ile  Val Phe Leu Thr Asp  Ala Ser Trp Ser Ile  Gly Asp Asp 
    1160                 1165                 1170             


Asn Phe  Asn Lys Val Val Lys  Phe Ile Phe Asn Thr  Val Gly Gly 
    1175                 1180                 1185             


Phe Asp  Glu Ile Ser Pro Ala  Gly Ile Gln Val Ser  Phe Val Gln 
    1190                 1195                 1200             


Tyr Ser  Asp Glu Val Lys Ser  Glu Phe Lys Leu Asn  Thr Tyr Asn 
    1205                 1210                 1215             


Asp Lys  Ala Leu Ala Leu Gly  Ala Leu Gln Asn Ile  Arg Tyr Arg 
    1220                 1225                 1230             


Gly Gly  Asn Thr Arg Thr Gly  Lys Ala Leu Thr Phe  Ile Lys Glu 
    1235                 1240                 1245             


Lys Val  Leu Thr Trp Glu Ser  Gly Met Arg Lys Asn  Val Pro Lys 
    1250                 1255                 1260             


Val Leu  Val Val Val Thr Asp  Gly Arg Ser Gln Asp  Glu Val Lys 
    1265                 1270                 1275             


Lys Ala  Ala Leu Val Ile Gln  Gln Ser Gly Phe Ser  Val Phe Val 
    1280                 1285                 1290             


Val Gly  Val Ala Asp Val Asp  Tyr Asn Glu Leu Ala  Asn Ile Ala 
    1295                 1300                 1305             


Ser Lys  Pro Ser Glu Arg His  Val Phe Ile Val Asp  Asp Phe Glu 
    1310                 1315                 1320             


Ser Phe  Glu Lys Ile Glu Asp  Asn Leu Ile Thr Phe  Val Cys Glu 
    1325                 1330                 1335             


Thr Ala  Thr Ser Ser Cys Pro  Leu Ile Tyr Leu Asp  Gly Tyr Thr 
    1340                 1345                 1350             


Ser Pro  Gly Phe Lys Met Leu  Glu Ala Tyr Asn Leu  Thr Glu Lys 
    1355                 1360                 1365             


Asn Phe  Ala Ser Val Gln Gly  Val Ser Leu Glu Ser  Gly Ser Phe 
    1370                 1375                 1380             


Pro Ser  Tyr Ser Ala Tyr Arg  Ile Gln Lys Asn Ala  Phe Val Asn 
    1385                 1390                 1395             


Gln Pro  Thr Ala Asp Leu His  Pro Asn Gly Leu Pro  Pro Ser Tyr 
    1400                 1405                 1410             


Thr Ile  Ile Leu Leu Phe Arg  Leu Leu Pro Glu Thr  Pro Ser Asp 
    1415                 1420                 1425             


Pro Phe  Ala Ile Trp Gln Ile  Thr Asp Arg Asp Tyr  Lys Pro Gln 
    1430                 1435                 1440             


Val Gly  Val Ile Ala Asp Pro  Ser Ser Lys Thr Leu  Ser Phe Phe 
    1445                 1450                 1455             


Asn Lys  Asp Thr Arg Gly Glu  Val Gln Thr Val Thr  Phe Asp Thr 
    1460                 1465                 1470             


Glu Glu  Val Lys Thr Leu Phe  Tyr Gly Ser Phe His  Lys Val His 
    1475                 1480                 1485             


Ile Val  Val Thr Ser Lys Ser  Val Lys Ile Tyr Ile  Asp Cys Tyr 
    1490                 1495                 1500             


Glu Ile  Ile Glu Lys Asp Ile  Lys Glu Ala Gly Asn  Ile Thr Thr 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Ile Leu Gly  Lys Leu Leu Lys Gly  Glu Arg Lys 
    1520                 1525                 1530             


Ser Ala  Ala Phe Gln Ile Gln  Ser Phe Asp Ile Val  Cys Ser Pro 
    1535                 1540                 1545             


Val Trp  Thr Ser Arg Asp Arg  Cys Cys Asp Ile Pro  Ser Arg Arg 
    1550                 1555                 1560             


Asp Glu  Gly Lys Cys Pro Ala  Phe Pro Asn Ser Cys  Thr Cys Thr 
    1565                 1570                 1575             


Gln Asp  Ser Val Gly Pro Pro  Gly Pro Pro Gly Pro  Ala Gly Gly 
    1580                 1585                 1590             


Pro Gly  Ala Lys Gly Pro Arg  Gly Glu Arg Gly Ile  Ser Gly Ala 
    1595                 1600                 1605             


Ile Gly  Pro Pro Gly Pro Arg  Gly Asp Ile Gly Pro  Pro Gly Pro 
    1610                 1615                 1620             


Gln Gly  Pro Pro Gly Pro Gln  Gly Pro Asn Gly Leu  Ser Ile Pro 
    1625                 1630                 1635             


Gly Glu  Gln Gly Arg Gln Gly  Met Lys Gly Asp Ala  Gly Glu Pro 
    1640                 1645                 1650             


Gly Leu  Pro Gly Arg Thr Gly  Thr Pro Gly Leu Pro  Gly Pro Pro 
    1655                 1660                 1665             


Gly Pro  Met Gly Pro Pro Gly  Asp Arg Gly Phe Thr  Gly Lys Asp 
    1670                 1675                 1680             


Ser Ala  Met Gly Pro Arg Gly  Pro Pro Gly Arg Pro  Gly Ser Pro 
    1685                 1690                 1695             


Gly Ser  Pro Gly Val Thr Gly  Pro Ser Gly Lys Pro  Gly Lys Pro 
    1700                 1705                 1710             


Gly Asp  His Gly Arg Pro Gly  Pro Ser Gly Leu Lys  Gly Glu Lys 
    1715                 1720                 1725             


Gly Asp  Arg Gly Asp Ile Ala  Ser Gln Asn Met Met  Arg Ala Val 
    1730                 1735                 1740             


Ala Arg  Gln Val Cys Glu Gln  Leu Ile Ser Gly Gln  Met Asn Arg 
    1745                 1750                 1755             


Phe Asn  Gln Met Leu Asn Gln  Ile Pro Asn Asp Tyr  Gln Ser Ser 
    1760                 1765                 1770             


Arg Asn  Gln Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ser 
    1775                 1780                 1785             


Ala Gly  Ala Arg Gly Glu Pro  Gly Pro Gly Gly Arg  Pro Gly Phe 
    1790                 1795                 1800             


Pro Gly  Thr Pro Gly Met Gln  Gly Pro Pro Gly Glu  Arg Gly Leu 
    1805                 1810                 1815             


Pro Gly  Glu Lys Gly Glu Arg  Gly Thr Gly Ser Ser  Gly Pro Arg 
    1820                 1825                 1830             


Gly Leu  Pro Gly Pro Pro Gly  Pro Gln Gly Glu Ser  Arg Thr Gly 
    1835                 1840                 1845             


Pro Pro  Gly Ser Thr Gly Ser  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1850                 1855                 1860             


Arg Pro  Gly Asn Ser Gly Ile  Gln Gly Pro Pro Gly  Pro Pro Gly 
    1865                 1870                 1875             


Tyr Cys  Asp Ser Ser Gln Cys  Ala Ser Ile Pro Tyr  Asn Gly Gln 
    1880                 1885                 1890             


Ser Tyr  Pro Gly Ser Gly 
    1895                 


<210>  775
<211>  470
<212>  DNA
<213>  Homosapiens

<400>  775
gtagttccgg ttccggcgtg gccattttcg ttggtggtgt tcagttgtgg cggttgctgg     60

tcagtaacag ccaagatgct gcggaatctg ctggctcttc gtcagattgg gcagaggacg    120

ataagcactg cttcccgcag gcattttaaa aataaagttc cggagaagca aaaactgttc    180

caggaggatg atgaaattcc actgtatcta aagggtgggg tagctgatgc cctcctgtat    240

agagccacca tgattcttac agttggtgga acagcatatg ccatatatga gctggctgtg    300

gcttcatttc ccaagaagca ggagtgactt cagtcatccc agcaatcgct tggttcagtt    360

tcattcagct ctctatggac cagtaatctg ataaataacc gagctcttct ttggggatca    420

atatttattg acttgtagta actgccacca ataaagcagt ctttaccatg               470


<210>  776
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  776

Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
1               5                   10                  15      


Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln 
            20                  25                  30          


Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly 
        35                  40                  45              


Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly 
    50                  55                  60                  


Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys 
65                  70                  75                  80  


Lys Gln Glu 
            


<210>  777
<211>  4410
<212>  DNA
<213>  Homosapiens

<400>  777
cggacgcgtg gggctggcgg tggcgctggt ggctgcggcg gcggcggcgg cagcggcgct     60

cgagcggttc ctgtcagggt cagccggcgg gccccctggg tggtccacct gcaaatcgcg    120

gagcggcgcc ccagggatcg atggcgatga actataacgc gaaggatgaa gtggacggtg    180

ggcccccgtg tgctccgggg ggcaccgcga agactcggag accggataac acggccttca    240

aacagcaacg gctgccagct tggcagccca tccttacggc tggcacggtg ctacctattt    300

tcttcatcat cggtctcatc ttcattccca tcggcattgg catttttgtc acctccaaca    360

acatccgcga gatcgagatt gattataccg gaacagagcc ttccagtccc tgtaataaat    420

gtttatctcc ggatgtgaca ccttgctttt gtaccattaa cttcacactg gaaaagtcat    480

ttgagggcaa cgtgtttatg tattatggac tgtctaattt ctatcaaaac catcgtcgtt    540

acgtgaaatc tcgagatgat agtcaactaa atggagattc tagtgctttg cttaatccca    600

gtaaggaatg tgaaccttat cgaagaaatg aagacaaacc aattgctcct tgtggagcta    660

ttgccaacag catgtttaat gatacattag aattgtttct cattggcaat gattcttatc    720

ctatacctat cgctttgaaa aagaaaggta ttgcttggtg gacagataaa aatgtgaaat    780

tcagaaatcc ccctggagga gacaacctgg aagaacgatt taaaggtaca acaaagcctg    840

tgaactggct taaaccagtt tacatgctgg attctgaccc agataataat ggattcataa    900

atgaggattt tattgtttgg atgcgtactg cagcattacc tacttttcgc aagttgtatc    960

gtcttataga aaggaaaagt gatttacatc caacattacc agctggccga tactctttga   1020

atgtcacata caattaccct gtacattatt ttgatggacg aaaacggatg atcttgagca   1080

ctatttcatg gatgggagga aaaaatccat ttttggggat tgcttacatc gctgttggat   1140

ccatctcctt ccttctggga gttgtactgc tagtaattaa tcataaatat agaaacagta   1200

gtaatacagc tgacattacc atttaatttt atattatgaa agcaaatcat ctgcatgtgc   1260

atcaaggcca gtcctattca acctagcttt cgaatgctga tatctggtta gtatgtcatt   1320

ttgaagttgg cacataactt ttctaaaaaa aagcagtctt tgttgtttgc ttcttcccta   1380

cggatgactt ctaaaaatat atgacgggta taaaaaaatt agctatattg atcatatcaa   1440

cactgtaact gctgaaatgg cattctaatg tttgcttttt attcggacag gccacatgat   1500

gcatagagcc tctttcatgt gacttgtgtc tactgcttaa atctttatgc tgtgttgatg   1560

atattatatt gacatatgaa gctgtatatg tgtatgtatt ttgtggagaa agggattaca   1620

agatgtatga gtataatgac ttgctaacct ttcaggattc agagaaagat gaagaaagac   1680

catatctaaa taatacactt catcattttc atgtgtataa atgcttaaag taccatcttt   1740

gttgaggtgg ttcatgtatc cagtttatcc agtacagtta tttgtcaagc ttagctttga   1800

tttcaaagga cacgcttacc ttgtctggca taagaattaa tgctcatgtc tgcagtggtt   1860

gggtaggtcc tgcttaggag aattaaaaaa ttcctctttc cgtttggttg aatgttgcag   1920

tcaggaaccc caactcactt ggaatgtttt tatatgtaat catttccctt gaagcttata   1980

ctttataagg gaagaaagaa ttcaggtgat atgggaaaac tgcttggcag accttcatct   2040

tctgcctcaa ctgtaaacca catgtaaatg cttaatggag actgttttca ttcttgtgat   2100

atttaacatt cagaaaatta cttcagcttt ggaaatactc aggctgtttt tattctgcag   2160

gtaagtgttt tgacttaagt actaatattc cagaaatttt tgaaagcagt aaccttaatt   2220

tcctatgtat ttcattccac ttttgcatat aggtcaaata gcaatgtgta tgcacattct   2280

ctttagttaa ggcaccaatt gttttggttg gttttcctaa gacatacttt aaaaagatgt   2340

tctataaatt tcctagttaa attatgggga ttttggagta tgtacatgat aaattataat   2400

acgtatatgg ttgaagttat tttatttttt actaatgaat tattttaata ttccttattg   2460

aataaatgct gtaacttgtt tgctatggaa cttattctta aagttctagt taaaaataat   2520

ttttccacat gcatgaaaat atgtattaat cagaggtggc ttaattacat tgaaattgct   2580

tttttgttgt tgttttttta ctgaaataac tcatgtttgt gtagaagaat gcctgtttac   2640

tcagagttta tattttcctt cagttatatt ttaaatcaaa aggtctgggt aatgtatact   2700

tttgattaat atatactttt tttaaaaaac aaaaaacaat gtaatggtta atagtagaaa   2760

tgtgccacac ttttcaagtt ttatataaca tatgaaattc agttaaaaga atgtgtgttt   2820

cataatgact tttaactggt aaaaatatta cttgcacgaa gtacttgatg tatggttatc   2880

ctgaaatttc ggagtatttg gtgtgttctt tgtctaaaaa tagtctgttt tgtcagtcct   2940

tcagaatatt atttattctg aagattgtcc ctcttgcact tggcagttta tttttgggga   3000

tacattgttg ggggagaggg gtttctgcca ctctttccag attgagtctg tgctgtttaa   3060

ggaggactac catcctgcaa ctctttttct aattggggca cagaggatgt cgctaaagaa   3120

aagttgaaga gaccctttca gcactttctc atctgtggag aagatggaat cttaaaatac   3180

atttggagtt ttatctgttt tacaagtcca ttgatggcct aagttcctcc tgttttctgc   3240

tgtttgatct ctaaggaact cctgttgcta aatatgaaga gtatggaaca ttcatatagt   3300

ctctgtgaag catgggggga gggaagacat ttctttttct tataggcttt atgctcaaat   3360

gtcatagtct cctttcaaag aattgtgttg cattttaaat gcacccagct taagtagaag   3420

acattgaagg atgcattaat tttcaggaac tattttgaat tatgaaaaga ttcccaattg   3480

aaaaaattat tcaacaagta aaagctaaga aatttcattg aaatcataag gcagtttaag   3540

cataaattga taaaaatagc tgtgtactac taattaatag aaaatcattc aaccaagaga   3600

agagtcaagt gaatatcgtt tgtttatttg ctagtgagtt tctttgtaac gttgatttta   3660

ttaaatgata atatttggtt agtatgtcct atgttaataa aaatgaacaa aattaatttt   3720

gctatgttca ggtgtcttga taaaataaca atgctccagt gttgttgctt acatttagca   3780

ctaaatttta acacagggtc agtgagtcca ggttttaact tcttcatgcc tggatgggat   3840

aaaatgtaat tcattgttaa attaattcat atttgtattt attaatcact gtgacaacat   3900

taaccatttg ttcttaccag gaagtggtca gattatcatc tgagttacag ttagactggc   3960

taagtttggt attagatcaa ggggaatgtc cagtaaacag agaggtaagc atgatggaaa   4020

taatgaagtg gggtacacag gaaaaacctg actagtgagg aggagcagct gagagatagg   4080

gtcagtgaat gcggttcagc ctgctacctc tcctgtcttc atagaaccat tgccttagaa   4140

ttattgtatg acacgttttt tgttggttaa gctgtaaggt tttgttcttt gtgaacatgg   4200

gtattttgag gggagggtgg agggagtagg gaagtggtcc ttttacaaga attttgatgc   4260

ataagtgtct attgtagggt ttggatgatc tagtaaagtg ttttagaacc cctttttatc   4320

ccatgcacca ttcagtaaac ataaaaatca caattctgct aatgtcattt ggaacttcaa   4380

aataaatatc ttgtctaaaa acaaaaaaaa                                    4410


<210>  778
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  778

Met Ala Met Asn Tyr Asn Ala Lys Asp Glu Val Asp Gly Gly Pro Pro 
1               5                   10                  15      


Cys Ala Pro Gly Gly Thr Ala Lys Thr Arg Arg Pro Asp Asn Thr Ala 
            20                  25                  30          


Phe Lys Gln Gln Arg Leu Pro Ala Trp Gln Pro Ile Leu Thr Ala Gly 
        35                  40                  45              


Thr Val Leu Pro Ile Phe Phe Ile Ile Gly Leu Ile Phe Ile Pro Ile 
    50                  55                  60                  


Gly Ile Gly Ile Phe Val Thr Ser Asn Asn Ile Arg Glu Ile Glu Ile 
65                  70                  75                  80  


Asp Tyr Thr Gly Thr Glu Pro Ser Ser Pro Cys Asn Lys Cys Leu Ser 
                85                  90                  95      


Pro Asp Val Thr Pro Cys Phe Cys Thr Ile Asn Phe Thr Leu Glu Lys 
            100                 105                 110         


Ser Phe Glu Gly Asn Val Phe Met Tyr Tyr Gly Leu Ser Asn Phe Tyr 
        115                 120                 125             


Gln Asn His Arg Arg Tyr Val Lys Ser Arg Asp Asp Ser Gln Leu Asn 
    130                 135                 140                 


Gly Asp Ser Ser Ala Leu Leu Asn Pro Ser Lys Glu Cys Glu Pro Tyr 
145                 150                 155                 160 


Arg Arg Asn Glu Asp Lys Pro Ile Ala Pro Cys Gly Ala Ile Ala Asn 
                165                 170                 175     


Ser Met Phe Asn Asp Thr Leu Glu Leu Phe Leu Ile Gly Asn Asp Ser 
            180                 185                 190         


Tyr Pro Ile Pro Ile Ala Leu Lys Lys Lys Gly Ile Ala Trp Trp Thr 
        195                 200                 205             


Asp Lys Asn Val Lys Phe Arg Asn Pro Pro Gly Gly Asp Asn Leu Glu 
    210                 215                 220                 


Glu Arg Phe Lys Gly Thr Thr Lys Pro Val Asn Trp Leu Lys Pro Val 
225                 230                 235                 240 


Tyr Met Leu Asp Ser Asp Pro Asp Asn Asn Gly Phe Ile Asn Glu Asp 
                245                 250                 255     


Phe Ile Val Trp Met Arg Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu 
            260                 265                 270         


Tyr Arg Leu Ile Glu Arg Lys Ser Asp Leu His Pro Thr Leu Pro Ala 
        275                 280                 285             


Gly Arg Tyr Ser Leu Asn Val Thr Tyr Asn Tyr Pro Val His Tyr Phe 
    290                 295                 300                 


Asp Gly Arg Lys Arg Met Ile Leu Ser Thr Ile Ser Trp Met Gly Gly 
305                 310                 315                 320 


Lys Asn Pro Phe Leu Gly Ile Ala Tyr Ile Ala Val Gly Ser Ile Ser 
                325                 330                 335     


Phe Leu Leu Gly Val Val Leu Leu Val Ile Asn His Lys Tyr Arg Asn 
            340                 345                 350         


Ser Ser Asn Thr Ala Asp Ile Thr Ile 
        355                 360     


<210>  779
<211>  4629
<212>  DNA
<213>  Homosapiens

<400>  779
agtgttgtga agggagcaga agaggagaaa cctaatctcc gaacccaaca acacctagca     60

acagtagaaa aaacttttaa acaaaagtct gggtgggaga tatacaacaa cttccaattt    120

ctgctgatcg ggatttcagg gagaagaagc tgctttccct cctctctact ctgtttcctg    180

catgacttca gctattggct ggtcctggga aagaaagtgg gaaaagcttt ttcctctgta    240

ttcttttggg ctggatagtt tttgagaact cgaatctgtc ttgggctgtg agacaagcca    300

ctgggttctt caaaggataa actacctaca tagaggacat acctttggtt aaaggagctg    360

ccgtcaggtg ggaatgagat ctcgaaacca aggtggtgaa agtgcatctg atgggcatat    420

ctcctgtccc aagccctcca tcatcggcaa tgctggtgaa aaaagtctct cagaagatgc    480

aaaaaagaag aagaaatcaa ataggaagga ggatgatgtc atggcctcag gaactgtcaa    540

acgacaccta aaaacatctg gagaatgtga acgaaaaact aagaaatccc tggagttatc    600

caaagaagac ctcatccaac tactcagtat aatggaaggg gagttgcagg ccagagaaga    660

tgtgatccac atgctgaaga cagagaaaac caagcctgag gttctggagg ctcattacgg    720

gtctgcggag ccagagaaag tgctgcgggt cctgcaccga gatgccattc ttgcccagga    780

gaaatccata ggagaagatg tctatgagaa accgatttca gagctggaca gacttgagga    840

aaaacagaaa gaaacctacc ggcgcatgct agagcagctg ttgctggccg agaagtgtca    900

taggcgcacc gtatacgagt tagagaacga gaagcataaa cacactgact acatgaacaa    960

gagcgacgac ttcaccaacc tgctggagca ggagcgggag aggttaaaaa agctccttga   1020

acaagaaaag gcttatcaag cccgcaaaga aaaggaaaat gctaaacgac tcaataaact   1080

aagagatgag cttgttaaac tcaaatcctt tgcactcatg ctggtggatg aaagacaaat   1140

gcacattgaa caacttggcc tgcaaagcca gaaagtacag gatcttactc agaagctgag   1200

ggaagaagaa gagaagctca aagccattac ttccaaatcc aaagaagaca gacagaaatt   1260

gctcaagtta gaagtggact ttgaacacaa ggcttcgagg ttttctcaag agcatgaaga   1320

gatgaacgct aaactggcta atcaagagtc tcacaatagg caacttagac tcaagctggt   1380

tggcttaacc caaagaatcg aggagctaga agagaccaac aaaaatctgc agaaggcaga   1440

ggaagaactt caagaattaa gagataaaat tgccaaagga gaatgtggaa actctagcct   1500

catggcagaa gtggaaaatc ttcgaaagcg tgtgcttgaa atggaaggta aagatgagga   1560

gatcactaaa actgaatccc agtgtaggga attgaggaag aagctgcaag aggaagaaca   1620

ccatagtaag gagctcagac ttgaagttga gaagctacag aagagaatgt ctgaactaga   1680

gaaattggaa gaagcattta gcaagagtaa atctgagtgc acccagctac atttaaatct   1740

ggagaaagaa aagaacttaa ccaaagacct gctaaatgaa ttggaggtgg tcaagagtcg   1800

agttaaagaa ttggaatgtt ctgaaagtag attggaaaag gctgaattaa gcctaaaaga   1860

tgatcttacc aagttgaagt catttaccgt gatgctggtt gatgaaagga aaaatatgat   1920

ggaaaaaata aaacaagaag agagaaaagt ggatggactc aataaaaatt ttaaggtgga   1980

acaaggaaaa gttatggatg taactgaaaa actaattgaa gaaagtaaga aacttttaaa   2040

actaaaatct gaaatggagg aaaaagtata caacttgaca agagaaagag atgagttgat   2100

aggcaaattg aaaagtgaag aagaaaaatc ctctgaatta agctgcagtg ttgacttact   2160

aaagaagaga cttgatggta tagaggaagt ggaaagagaa ataacaagag gaaggtcacg   2220

aaaagggtct gagctcacct gcccggaaga taataagatt aaggaactaa cacttgaaat   2280

tgagagactg aagaaacgtc tccaacaatt ggaagtggtc gaaggggatt tgatgaagac   2340

agaagatgag tatgatcagc tggaacagaa atttagaact gagcaggata aggctaactt   2400

cctctctcaa caactagagg agatcaagca ccaaattgcc aagaataaag caatagagaa   2460

gggtgaggtt gtgagccagg aagctgaact gagacacaga tttcggttgg aagaagctaa   2520

aagtcgagac ttaaaagccg aagtacaagc tcttaaagag aagattcacg aattaatgaa   2580

caaagaagat cagctttctc agctccaggt agattattct gtacttcaac aaagatttat   2640

ggaagaagaa aataagaaca aaaacatggg gcaggaggtt ctcaatctga ccaaagagtt   2700

ggagctttcc aagcgctaca gcagagctct taggcccagt gtgaatggaa gaagaatggt   2760

ggatgttcct gtgacgtcaa ctggagtcca aactgatgca gtcagcggtg aagcagcaga   2820

ggaagaaacg ccagctgtat tcatacggaa atccttccag gaagaaaatc atattatgag   2880

taatcttcgg caggtgggat tgaagaaacc cgtggaaaga tcttctgttc tagacaggta   2940

tcctccagca gcaaatgagc tcactatgag aaagtcttgg attccatgga tgagaaagag   3000

ggaaaacggc ccctccatca ctcaggagaa agggccccga acaaattcca gtccagggca   3060

cccaggagag gtagtccttt caccaaagca gggccagccc ctgcatattc gagtgacacc   3120

agaccacgag aacagcactg cgactttgga gataacaagc ccgacatctg aagaattttt   3180

ttctagtacc actgtcattc ctaccttagg gaatcagaaa ccaagaataa ccattattcc   3240

atcaccaaac gttatgcctc aaaaacaaaa aagtggagat actactcttg gcccagaacg   3300

agccatgtcc ccagtcacaa ttactacatt ttccagagag aagactccag aaagtggaag   3360

aggcgcattt gcagacaggc ccacatcccc tattcagata atgacggtgt ctacatcagc   3420

agcaccagct gagattgcag tttctcccga atcccaggaa atgcccatgg gacggacaat   3480

cctcaaagtc accccagaaa aacagactgt tccaactcca gtacggaaat acaactccaa   3540

tgccaatatc ataaccacag aggacaataa aattcacatt cacttagggt ctcagtttaa   3600

acggtcccct gggacttcag gtgaaggagt cagtccagtt attactgtcc gaccagtaaa   3660

cgtgacagcc gaaaaggagg tttccaccgg cactgtcctt cgctctccca ggaatcacct   3720

ctcctcacgg cctggtgcaa gcaaagtgac gagcactatc accataacac cggtcacaac   3780

gtcatctgct cgaggaaccc agtcagtgtc aggacaagac gggtcatccc agcggcctac   3840

acccacccgc attcctatgt caaaaggtat gaaagcagga aagccagtag tggcagcccc   3900

aggagcagga aatctgacca aattcgagcc tcgagctgag actcagtcta tgaaaataga   3960

gctgaagaaa tctgcagcca gcagcaccac ctctctcgga ggggggaagg gctgagggca   4020

gtggctaagg gggtatgttg tgcagatgct actgctgccg tgaaagtgaa ccttcatctg   4080

tttgtgccag ttctttacat gtactaattt aagttttaaa tattgtgttt ataaaataac   4140

caactaataa ccatttgtct ttcccatttt gtgcatttgt tttgatgctg gggaacaaaa   4200

ttagcaaaac tattgcttgc tgcctagaag ccagggcgtg gtttctagtt ccagttttgc   4260

ttctagcaag tggacccatc aatagaccca tctgagcctg tttcctcatc agttagatgt   4320

ggggactcaa tcacacgctc ttcaagtccg gctcccatat ttcctaattg caagccaaat   4380

ttaatgtacc ttgttccaca ataatttttt attaaaaaaa tcctattaca aaataagaca   4440

tactttaact attgtcattt gcctctttca catcatgaat ttgctttatg tgctggaaaa   4500

aacatcacat agctatcaca gggcctggac ctctaaaatt ttgcaaaaac aaaaggttct   4560

aagatgattt caggaaataa tgtgaacatg taataaaatg gaaatgaaat atggaatcct   4620

aaaaaaaaa                                                           4629


<210>  780
<211>  1213
<212>  PRT
<213>  Homosapiens

<400>  780

Met Arg Ser Arg Asn Gln Gly Gly Glu Ser Ala Ser Asp Gly His Ile 
1               5                   10                  15      


Ser Cys Pro Lys Pro Ser Ile Ile Gly Asn Ala Gly Glu Lys Ser Leu 
            20                  25                  30          


Ser Glu Asp Ala Lys Lys Lys Lys Lys Ser Asn Arg Lys Glu Asp Asp 
        35                  40                  45              


Val Met Ala Ser Gly Thr Val Lys Arg His Leu Lys Thr Ser Gly Glu 
    50                  55                  60                  


Cys Glu Arg Lys Thr Lys Lys Ser Leu Glu Leu Ser Lys Glu Asp Leu 
65                  70                  75                  80  


Ile Gln Leu Leu Ser Ile Met Glu Gly Glu Leu Gln Ala Arg Glu Asp 
                85                  90                  95      


Val Ile His Met Leu Lys Thr Glu Lys Thr Lys Pro Glu Val Leu Glu 
            100                 105                 110         


Ala His Tyr Gly Ser Ala Glu Pro Glu Lys Val Leu Arg Val Leu His 
        115                 120                 125             


Arg Asp Ala Ile Leu Ala Gln Glu Lys Ser Ile Gly Glu Asp Val Tyr 
    130                 135                 140                 


Glu Lys Pro Ile Ser Glu Leu Asp Arg Leu Glu Glu Lys Gln Lys Glu 
145                 150                 155                 160 


Thr Tyr Arg Arg Met Leu Glu Gln Leu Leu Leu Ala Glu Lys Cys His 
                165                 170                 175     


Arg Arg Thr Val Tyr Glu Leu Glu Asn Glu Lys His Lys His Thr Asp 
            180                 185                 190         


Tyr Met Asn Lys Ser Asp Asp Phe Thr Asn Leu Leu Glu Gln Glu Arg 
        195                 200                 205             


Glu Arg Leu Lys Lys Leu Leu Glu Gln Glu Lys Ala Tyr Gln Ala Arg 
    210                 215                 220                 


Lys Glu Lys Glu Asn Ala Lys Arg Leu Asn Lys Leu Arg Asp Glu Leu 
225                 230                 235                 240 


Val Lys Leu Lys Ser Phe Ala Leu Met Leu Val Asp Glu Arg Gln Met 
                245                 250                 255     


His Ile Glu Gln Leu Gly Leu Gln Ser Gln Lys Val Gln Asp Leu Thr 
            260                 265                 270         


Gln Lys Leu Arg Glu Glu Glu Glu Lys Leu Lys Ala Ile Thr Ser Lys 
        275                 280                 285             


Ser Lys Glu Asp Arg Gln Lys Leu Leu Lys Leu Glu Val Asp Phe Glu 
    290                 295                 300                 


His Lys Ala Ser Arg Phe Ser Gln Glu His Glu Glu Met Asn Ala Lys 
305                 310                 315                 320 


Leu Ala Asn Gln Glu Ser His Asn Arg Gln Leu Arg Leu Lys Leu Val 
                325                 330                 335     


Gly Leu Thr Gln Arg Ile Glu Glu Leu Glu Glu Thr Asn Lys Asn Leu 
            340                 345                 350         


Gln Lys Ala Glu Glu Glu Leu Gln Glu Leu Arg Asp Lys Ile Ala Lys 
        355                 360                 365             


Gly Glu Cys Gly Asn Ser Ser Leu Met Ala Glu Val Glu Asn Leu Arg 
    370                 375                 380                 


Lys Arg Val Leu Glu Met Glu Gly Lys Asp Glu Glu Ile Thr Lys Thr 
385                 390                 395                 400 


Glu Ser Gln Cys Arg Glu Leu Arg Lys Lys Leu Gln Glu Glu Glu His 
                405                 410                 415     


His Ser Lys Glu Leu Arg Leu Glu Val Glu Lys Leu Gln Lys Arg Met 
            420                 425                 430         


Ser Glu Leu Glu Lys Leu Glu Glu Ala Phe Ser Lys Ser Lys Ser Glu 
        435                 440                 445             


Cys Thr Gln Leu His Leu Asn Leu Glu Lys Glu Lys Asn Leu Thr Lys 
    450                 455                 460                 


Asp Leu Leu Asn Glu Leu Glu Val Val Lys Ser Arg Val Lys Glu Leu 
465                 470                 475                 480 


Glu Cys Ser Glu Ser Arg Leu Glu Lys Ala Glu Leu Ser Leu Lys Asp 
                485                 490                 495     


Asp Leu Thr Lys Leu Lys Ser Phe Thr Val Met Leu Val Asp Glu Arg 
            500                 505                 510         


Lys Asn Met Met Glu Lys Ile Lys Gln Glu Glu Arg Lys Val Asp Gly 
        515                 520                 525             


Leu Asn Lys Asn Phe Lys Val Glu Gln Gly Lys Val Met Asp Val Thr 
    530                 535                 540                 


Glu Lys Leu Ile Glu Glu Ser Lys Lys Leu Leu Lys Leu Lys Ser Glu 
545                 550                 555                 560 


Met Glu Glu Lys Val Tyr Asn Leu Thr Arg Glu Arg Asp Glu Leu Ile 
                565                 570                 575     


Gly Lys Leu Lys Ser Glu Glu Glu Lys Ser Ser Glu Leu Ser Cys Ser 
            580                 585                 590         


Val Asp Leu Leu Lys Lys Arg Leu Asp Gly Ile Glu Glu Val Glu Arg 
        595                 600                 605             


Glu Ile Thr Arg Gly Arg Ser Arg Lys Gly Ser Glu Leu Thr Cys Pro 
    610                 615                 620                 


Glu Asp Asn Lys Ile Lys Glu Leu Thr Leu Glu Ile Glu Arg Leu Lys 
625                 630                 635                 640 


Lys Arg Leu Gln Gln Leu Glu Val Val Glu Gly Asp Leu Met Lys Thr 
                645                 650                 655     


Glu Asp Glu Tyr Asp Gln Leu Glu Gln Lys Phe Arg Thr Glu Gln Asp 
            660                 665                 670         


Lys Ala Asn Phe Leu Ser Gln Gln Leu Glu Glu Ile Lys His Gln Ile 
        675                 680                 685             


Ala Lys Asn Lys Ala Ile Glu Lys Gly Glu Val Val Ser Gln Glu Ala 
    690                 695                 700                 


Glu Leu Arg His Arg Phe Arg Leu Glu Glu Ala Lys Ser Arg Asp Leu 
705                 710                 715                 720 


Lys Ala Glu Val Gln Ala Leu Lys Glu Lys Ile His Glu Leu Met Asn 
                725                 730                 735     


Lys Glu Asp Gln Leu Ser Gln Leu Gln Val Asp Tyr Ser Val Leu Gln 
            740                 745                 750         


Gln Arg Phe Met Glu Glu Glu Asn Lys Asn Lys Asn Met Gly Gln Glu 
        755                 760                 765             


Val Leu Asn Leu Thr Lys Glu Leu Glu Leu Ser Lys Arg Tyr Ser Arg 
    770                 775                 780                 


Ala Leu Arg Pro Ser Val Asn Gly Arg Arg Met Val Asp Val Pro Val 
785                 790                 795                 800 


Thr Ser Thr Gly Val Gln Thr Asp Ala Val Ser Gly Glu Ala Ala Glu 
                805                 810                 815     


Glu Glu Thr Pro Ala Val Phe Ile Arg Lys Ser Phe Gln Glu Glu Asn 
            820                 825                 830         


His Ile Met Ser Asn Leu Arg Gln Val Gly Leu Lys Lys Pro Val Glu 
        835                 840                 845             


Arg Ser Ser Val Leu Asp Arg Tyr Pro Pro Ala Ala Asn Glu Leu Thr 
    850                 855                 860                 


Met Arg Lys Ser Trp Ile Pro Trp Met Arg Lys Arg Glu Asn Gly Pro 
865                 870                 875                 880 


Ser Ile Thr Gln Glu Lys Gly Pro Arg Thr Asn Ser Ser Pro Gly His 
                885                 890                 895     


Pro Gly Glu Val Val Leu Ser Pro Lys Gln Gly Gln Pro Leu His Ile 
            900                 905                 910         


Arg Val Thr Pro Asp His Glu Asn Ser Thr Ala Thr Leu Glu Ile Thr 
        915                 920                 925             


Ser Pro Thr Ser Glu Glu Phe Phe Ser Ser Thr Thr Val Ile Pro Thr 
    930                 935                 940                 


Leu Gly Asn Gln Lys Pro Arg Ile Thr Ile Ile Pro Ser Pro Asn Val 
945                 950                 955                 960 


Met Pro Gln Lys Gln Lys Ser Gly Asp Thr Thr Leu Gly Pro Glu Arg 
                965                 970                 975     


Ala Met Ser Pro Val Thr Ile Thr Thr Phe Ser Arg Glu Lys Thr Pro 
            980                 985                 990         


Glu Ser Gly Arg Gly Ala Phe Ala  Asp Arg Pro Thr Ser  Pro Ile Gln 
        995                 1000                 1005             


Ile Met  Thr Val Ser Thr Ser  Ala Ala Pro Ala Glu  Ile Ala Val 
    1010                 1015                 1020             


Ser Pro  Glu Ser Gln Glu Met  Pro Met Gly Arg Thr  Ile Leu Lys 
    1025                 1030                 1035             


Val Thr  Pro Glu Lys Gln Thr  Val Pro Thr Pro Val  Arg Lys Tyr 
    1040                 1045                 1050             


Asn Ser  Asn Ala Asn Ile Ile  Thr Thr Glu Asp Asn  Lys Ile His 
    1055                 1060                 1065             


Ile His  Leu Gly Ser Gln Phe  Lys Arg Ser Pro Gly  Thr Ser Gly 
    1070                 1075                 1080             


Glu Gly  Val Ser Pro Val Ile  Thr Val Arg Pro Val  Asn Val Thr 
    1085                 1090                 1095             


Ala Glu  Lys Glu Val Ser Thr  Gly Thr Val Leu Arg  Ser Pro Arg 
    1100                 1105                 1110             


Asn His  Leu Ser Ser Arg Pro  Gly Ala Ser Lys Val  Thr Ser Thr 
    1115                 1120                 1125             


Ile Thr  Ile Thr Pro Val Thr  Thr Ser Ser Ala Arg  Gly Thr Gln 
    1130                 1135                 1140             


Ser Val  Ser Gly Gln Asp Gly  Ser Ser Gln Arg Pro  Thr Pro Thr 
    1145                 1150                 1155             


Arg Ile  Pro Met Ser Lys Gly  Met Lys Ala Gly Lys  Pro Val Val 
    1160                 1165                 1170             


Ala Ala  Pro Gly Ala Gly Asn  Leu Thr Lys Phe Glu  Pro Arg Ala 
    1175                 1180                 1185             


Glu Thr  Gln Ser Met Lys Ile  Glu Leu Lys Lys Ser  Ala Ala Ser 
    1190                 1195                 1200             


Ser Thr  Thr Ser Leu Gly Gly  Gly Lys Gly 
    1205                 1210             


<210>  781
<211>  3342
<212>  DNA
<213>  Homosapiens

<400>  781
aatatcaacc tgtttcctcc tcctccttct cctcctcctc cgtgacctcc tcctcctctt     60

tctcctgaga aacttcgccc cagcggtgcg gagcgccgct gcgcagccgg ggagggacgc    120

aggcaggcgg cgggcagcgg gaggcggcag cccggtgcgg tccccgcggc tctcggcgga    180

gccccgcgcc cgccgcgcca tggcccgaag accccggcac agcatatata gcagtgacga    240

ggatgatgag gactttgaga tgtgtgacca tgactatgat gggctgcttc ccaagtctgg    300

aaagcgtcac ttggggaaaa caaggtggac ccgggaagag gatgaaaaac tgaagaagct    360

ggtggaacag aatggaacag atgactggaa agttattgcc aattatctcc cgaatcgaac    420

agatgtgcag tgccagcacc gatggcagaa agtactaaac cctgagctca tcaagggtcc    480

ttggaccaaa gaagaagatc agagagtgat agagcttgta cagaaatacg gtccgaaacg    540

ttggtctgtt attgccaagc acttaaaggg gagaattgga aaacaatgta gggagaggtg    600

gcataaccac ttgaatccag aagttaagaa aacctcctgg acagaagagg aagacagaat    660

tatttaccag gcacacaaga gactggggaa cagatgggca gaaatcgcaa agctactgcc    720

tggacgaact gataatgcta tcaagaacca ctggaattct acaatgcgtc ggaaggtcga    780

acaggaaggt tatctgcagg agtcttcaaa agccagccag ccagcagtgg ccacaagctt    840

ccagaagaac agtcatttga tgggttttgc tcaggctccg cctacagctc aactccctgc    900

cactggccag cccactgtta acaacgacta ttcctattac cacatttctg aagcacaaaa    960

tgtctccagt catgttccat accctgtagc gttacatgta aatatagtca atgtccctca   1020

gccagctgcc gcagccattc agagacacta taatgatgaa gaccctgaga aggaaaagcg   1080

aataaaggaa ttagaattgc tcctaatgtc aaccgagaat gagctaaaag gacagcaggt   1140

gctaccaaca cagaaccaca catgcagcta ccccgggtgg cacagcacca ccattgccga   1200

ccacaccaga cctcatggag acagtgcacc tgtttcctgt ttgggagaac accactccac   1260

tccatctctg ccagcggatc ctggctccct acctgaagaa agcgcctcgc cagcaaggtg   1320

catgatcgtc caccagggca ccattctgga taatgttaag aacctcttag aatttgcaga   1380

aacactccaa tttatagatt ctttcttaaa cacttccagt aaccatgaaa actcagactt   1440

ggaaatgcct tctttaactt ccacccccct cattggtcac aaattgactg ttacaacacc   1500

atttcataga gaccagactg tgaaaactca aaaggaaaat actgttttta gaaccccagc   1560

tatcaaaagg tcaatcttag aaagctctcc aagaactcct acaccattca aacatgcact   1620

tgcagctcaa gaaattaaat acggtcccct gaagatgcta cctcagacac cctctcatct   1680

agtagaagat ctgcaggatg tgatcaaaca ggaatctgat gaatctggaa ttgttgctga   1740

gtttcaagaa aatggaccac ccttactgaa gaaaatcaaa caagaggtgg aatctccaac   1800

tgataaatca ggaaacttct tctgctcaca ccactgggaa ggggacagtc tgaataccca   1860

actgttcacg cagacctcgc ctgtggcaga tgcaccgaat attcttacaa gctccgtttt   1920

aatggcacca gcatcagaag atgaagacaa tgttctcaaa gcatttacag tacctaaaaa   1980

caggtccctg gcgagcccct tgcagccttg tagcagtacc tgggaacctg catcctgtgg   2040

aaagatggag gagcagatga catcttccag tcaagctcgt aaatacgtga atgcattctc   2100

agcccggacg ctggtcatgt gagacatttc cagaaaagca ttatggtttt cagaacactt   2160

caagttgact tgggatatat cattcctcaa catgaaactt ttcatgaatg ggagaagaac   2220

ctatttttgt tgtggtacaa cagttgagag cagcaccaag tgcatttagt tgaatgaagt   2280

cttcttggat ttcacccaac taaaaggatt tttaaaaata aataacagtc ttacctaaat   2340

tattaggtaa tgaattgtag ccagttgtta atatcttaat gcagattttt ttaaaaaaaa   2400

cataaaatga tttatctgta ttttaaagga tccaacagat cagtattttt tcctgtgatg   2460

ggttttttga aatttgacac attaaaaggt actccagtat ttcacttttc tcgatcacta   2520

aacatatgca tatattttta aaaatcagta aaagcattac tctaagtgta gacttaatac   2580

catgtgacat ttaatccaga ttgtaaatgc tcatttatgg ttaatgacat tgaaggtaca   2640

tttattgtac caaaccattt tatgagtttt ctgttagctt gctttaaaaa ttattactgt   2700

aagaaatagt tttataaaaa attatatttt tattcagtaa tttaattttg taaatgccaa   2760

atgaaaaacg ttttttgctg ctatggtctt agcctgtaga catgctgcta gtatcagagg   2820

ggcagtagag cttggacaga aagaaaagaa acttggtgtt aggtaattga ctatgcacta   2880

gtatttcaga ctttttaatt ttatatatat atacattttt tttccttctg caatacattt   2940

gaaaacttgt ttgggagact ctgcattttt tattgtggtt tttttgttat tgttggttta   3000

tacaagcatg cgttgcactt cttttttggg agatgtgtgt tgttgatgtt ctatgttttg   3060

ttttgagtgt agcctgactg ttttataatt tgggagttct gcatttgatc cgcatcccct   3120

gtggtttcta agtgtatggt ctcagaactg ttgcatggat cctgtgtttg caactgggga   3180

gacagaaact gtggttgata gccagtcact gccttaagaa catttgatgc aagatggcca   3240

gcactgaact tttgagatat gacggtgtac ttactgcctt gtagcaaaat aaagatgtgc   3300

ccttatttta cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                      3342


<210>  782
<211>  640
<212>  PRT
<213>  Homosapiens

<400>  782

Met Ala Arg Arg Pro Arg His Ser Ile Tyr Ser Ser Asp Glu Asp Asp 
1               5                   10                  15      


Glu Asp Phe Glu Met Cys Asp His Asp Tyr Asp Gly Leu Leu Pro Lys 
            20                  25                  30          


Ser Gly Lys Arg His Leu Gly Lys Thr Arg Trp Thr Arg Glu Glu Asp 
        35                  40                  45              


Glu Lys Leu Lys Lys Leu Val Glu Gln Asn Gly Thr Asp Asp Trp Lys 
    50                  55                  60                  


Val Ile Ala Asn Tyr Leu Pro Asn Arg Thr Asp Val Gln Cys Gln His 
65                  70                  75                  80  


Arg Trp Gln Lys Val Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr 
                85                  90                  95      


Lys Glu Glu Asp Gln Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro 
            100                 105                 110         


Lys Arg Trp Ser Val Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys 
        115                 120                 125             


Gln Cys Arg Glu Arg Trp His Asn His Leu Asn Pro Glu Val Lys Lys 
    130                 135                 140                 


Thr Ser Trp Thr Glu Glu Glu Asp Arg Ile Ile Tyr Gln Ala His Lys 
145                 150                 155                 160 


Arg Leu Gly Asn Arg Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg 
                165                 170                 175     


Thr Asp Asn Ala Ile Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys 
            180                 185                 190         


Val Glu Gln Glu Gly Tyr Leu Gln Glu Ser Ser Lys Ala Ser Gln Pro 
        195                 200                 205             


Ala Val Ala Thr Ser Phe Gln Lys Asn Ser His Leu Met Gly Phe Ala 
    210                 215                 220                 


Gln Ala Pro Pro Thr Ala Gln Leu Pro Ala Thr Gly Gln Pro Thr Val 
225                 230                 235                 240 


Asn Asn Asp Tyr Ser Tyr Tyr His Ile Ser Glu Ala Gln Asn Val Ser 
                245                 250                 255     


Ser His Val Pro Tyr Pro Val Ala Leu His Val Asn Ile Val Asn Val 
            260                 265                 270         


Pro Gln Pro Ala Ala Ala Ala Ile Gln Arg His Tyr Asn Asp Glu Asp 
        275                 280                 285             


Pro Glu Lys Glu Lys Arg Ile Lys Glu Leu Glu Leu Leu Leu Met Ser 
    290                 295                 300                 


Thr Glu Asn Glu Leu Lys Gly Gln Gln Val Leu Pro Thr Gln Asn His 
305                 310                 315                 320 


Thr Cys Ser Tyr Pro Gly Trp His Ser Thr Thr Ile Ala Asp His Thr 
                325                 330                 335     


Arg Pro His Gly Asp Ser Ala Pro Val Ser Cys Leu Gly Glu His His 
            340                 345                 350         


Ser Thr Pro Ser Leu Pro Ala Asp Pro Gly Ser Leu Pro Glu Glu Ser 
        355                 360                 365             


Ala Ser Pro Ala Arg Cys Met Ile Val His Gln Gly Thr Ile Leu Asp 
    370                 375                 380                 


Asn Val Lys Asn Leu Leu Glu Phe Ala Glu Thr Leu Gln Phe Ile Asp 
385                 390                 395                 400 


Ser Phe Leu Asn Thr Ser Ser Asn His Glu Asn Ser Asp Leu Glu Met 
                405                 410                 415     


Pro Ser Leu Thr Ser Thr Pro Leu Ile Gly His Lys Leu Thr Val Thr 
            420                 425                 430         


Thr Pro Phe His Arg Asp Gln Thr Val Lys Thr Gln Lys Glu Asn Thr 
        435                 440                 445             


Val Phe Arg Thr Pro Ala Ile Lys Arg Ser Ile Leu Glu Ser Ser Pro 
    450                 455                 460                 


Arg Thr Pro Thr Pro Phe Lys His Ala Leu Ala Ala Gln Glu Ile Lys 
465                 470                 475                 480 


Tyr Gly Pro Leu Lys Met Leu Pro Gln Thr Pro Ser His Leu Val Glu 
                485                 490                 495     


Asp Leu Gln Asp Val Ile Lys Gln Glu Ser Asp Glu Ser Gly Ile Val 
            500                 505                 510         


Ala Glu Phe Gln Glu Asn Gly Pro Pro Leu Leu Lys Lys Ile Lys Gln 
        515                 520                 525             


Glu Val Glu Ser Pro Thr Asp Lys Ser Gly Asn Phe Phe Cys Ser His 
    530                 535                 540                 


His Trp Glu Gly Asp Ser Leu Asn Thr Gln Leu Phe Thr Gln Thr Ser 
545                 550                 555                 560 


Pro Val Ala Asp Ala Pro Asn Ile Leu Thr Ser Ser Val Leu Met Ala 
                565                 570                 575     


Pro Ala Ser Glu Asp Glu Asp Asn Val Leu Lys Ala Phe Thr Val Pro 
            580                 585                 590         


Lys Asn Arg Ser Leu Ala Ser Pro Leu Gln Pro Cys Ser Ser Thr Trp 
        595                 600                 605             


Glu Pro Ala Ser Cys Gly Lys Met Glu Glu Gln Met Thr Ser Ser Ser 
    610                 615                 620                 


Gln Ala Arg Lys Tyr Val Asn Ala Phe Ser Ala Arg Thr Leu Val Met 
625                 630                 635                 640 


<210>  783
<211>  5538
<212>  DNA
<213>  Homosapiens

<400>  783
gcggcacaga gccgcggctt gctttcagga cacgggtcgc tggcgggtta ggtggctgcg     60

tggccgcctc acttcgcgca cgcgccgcta ggctggggga gttgatttgc actgctccgg    120

gtgtcggctc cggcgggacg ggcggttctg cgtacccctc tccagtgtca acctggggct    180

gaatcttcaa cctgtcaaag ccttcttaat tatgtctgag aaaaggatcc tgattgagtc    240

aatgctttgc attctcagtc ctctgcataa agctgagaga tgcctacagc tgagagtgaa    300

gcaaaagtaa aaaccaaagt tcgctttgaa gaattgctta agacccacag tgatctaatg    360

cgtgaaaaga aaaaactgaa gaaaaaactt gtcaggtctg aagaaaacat ctcacctgac    420

actattagaa gcaatcttca ctatatgaaa gaaactacaa gtgatgatcc cgacactatt    480

agaagcaatc ttccccatat taaagaaact acaagtgatg atgtaagtgc tgctaacact    540

aacaacctga agaagagcac gagagtcact aaaaacaaat tgaggaacac acagttagca    600

actgaaaatc ctaatggtga tgctagtgta gaggaagaca aacaaggaaa gccaaataaa    660

aaggtgataa agacggtgcc ccagttgact acacaagacc tgaaaccgga aactcctgag    720

aataaggttg attctacaca ccagaaaaca catacaaagc cacagccagg cgttgatcat    780

cagaaaagtg agaaggcaaa tgagggaaga gaagagactg atttagaaga ggatgaagaa    840

ttgatgcaag catatcagtg ccatgtaact gaagaaatgg caaaggagat taagaggaaa    900

ataagaaaga aactgaaaga acagttgact tactttccct cagatacttt attccatgat    960

gacaaactaa gcagtgaaaa aaggaaaaag aaaaaggaag ttccagtctt ctctaaagct   1020

gaaacaagta cattgaccat ctctggtgac acagttgaag gtgaacaaaa gaaagaatct   1080

tcagttagat cagtttcttc agattctcat caagatgatg aaataagctc aatggaacaa   1140

agcacagaag acagcatgca agatgataca aaacctaaac caaaaaaaac aaaaaagaag   1200

actaaagcag ttgcagataa taatgaagat gttgatggtg atggtgttca tgaaataaca   1260

agccgagata gcccggttta tcccaaatgt ttgcttgatg atgaccttgt cttgggagtt   1320

tacattcacc gaactgatag acttaagtca gattttatga tttctcaccc aatggtaaaa   1380

attcatgtgg ttgatgagca tactggtcaa tatgtcaaga aagatgatag tggacggcct   1440

gtttcatctt actatgaaaa agagaatgtg gattatattc ttcctattat gacccagcca   1500

tatgatttta aacagttaaa atcaagactt ccagagtggg aagaacaaat tgtatttaat   1560

gaaaattttc cctatttgct tcgaggctct gatgagagtc ctaaagtcat cctgttcttt   1620

gagattcttg atttcttaag cgtggatgaa attaagaata attctgaggt tcaaaaccaa   1680

gaatgtggct ttcggaaaat tgcctgggca tttcttaagc ttctgggagc caatggaaat   1740

gcaaacatca actcaaaact tcgcttgcag ctatattacc cacctactaa gcctcgatcc   1800

ccattaagtg ttgttgaggc atttgaatgg tggtcaaaat gtccaagaaa tcattaccca   1860

tcaacactgt acgtaactgt aagaggactg aaagttccag actgtataaa gccatcttac   1920

cgctctatga tggctcttca ggaggaaaaa ggtaaaccag tgcattgtga acgtcaccat   1980

gagtcaagct cagtagacac agaacctgga ttagaagagt caaaggaagt aataaagtgg   2040

aaacgactcc ctgggcaggc ttgccgtatc ccaaacaaac acctcttctc actaaatgca   2100

ggagaacgag gatgtttttg tcttgatttc tcccacaatg gaagaatatt agcagcagct   2160

tgtgccagcc gggatggata tccaattatt ttatatgaaa ttccttctgg acgtttcatg   2220

agagaattgt gtggccacct caatatcatt tatgatcttt cctggtcaaa agatgatcac   2280

tacatcctta cttcatcatc tgatggcact gccaggatat ggaaaaatga aataaacaat   2340

acaaatactt tcagagtttt acctcatcct tcttttgttt acacggctaa attccatcca   2400

gctgtaagag agctagtagt tacaggatgc tatgattcca tgatacggat atggaaagtt   2460

gagatgagag aagattctgc catattggtc cgacagtttg atgttcacaa aagttttatc   2520

aactcacttt gttttgatac tgaaggtcat catatgtatt caggagattg tacaggggtg   2580

attgttgttt ggaataccta tgtcaagatt aatgatttgg aacattcagt gcaccactgg   2640

actataaata aggaaattaa agaaactgag tttaagggaa ttccaataag ttatttggag   2700

attcatccca atggaaaacg tttgttaatc cataccaaag acagtacttt gagaattatg   2760

gatctccgga tattagtagc aaggaagttt gtaggagcag caaattatcg ggagaagatt   2820

catagtactt tgactccatg tgggactttt ctgtttgctg gaagtgagga tggtatagtg   2880

tatgtttgga acccagaaac aggagaacaa gtagccatgt attctgactt gccattcaag   2940

tcacccattc gagacatttc ttatcatcca tttgaaaata tggttgcatt ctgtgcattt   3000

gggcaaaatg agccaattct tctgtatatt tacgatttcc atgttgccca gcaggaggct   3060

gaaatgttca aacgctacaa tggaacattt ccattacctg gaatacacca aagtcaagat   3120

gccctatgta cctgtccaaa actaccccat caaggctctt ttcagattga tgaatttgtc   3180

cacactgaaa gttcttcaac gaagatgcag ctagtaaaac agaggcttga aactgtcaca   3240

gaggtgatac gttcctgtgc tgcaaaagtc aacaaaaatc tctcatttac ttcaccacca   3300

gcagtttcct cacaacagtc taagttaaag cagtcaaaca tgctgaccgc tcaagagatt   3360

ctacatcagt ttggtttcac tcagaccggg attatcagca tagaaagaaa gccttgtaac   3420

catcaggtag atacagcacc aacggtagtg gctctttatg actacacagc gaatcgatca   3480

gatgaactaa ccatccatcg cggagacatt atccgagtgt ttttcaaaga taatgaagac   3540

tggtggtatg gcagcatagg aaagggacag gaaggttatt ttccagctaa tcatgtggct   3600

agtgaaacac tgtatcaaga actgcctcct gagataaagg agcgatcccc tcctttaagc   3660

cctgaggaaa aaactaaaat agaaaaatct ccagctcctc aaaagcaatc aatcaataag   3720

aacaagtccc aggacttcag actaggctca gaatctatga cacattctga aatgagaaaa   3780

gaacagagcc atgaggacca aggacacata atggatacac ggatgaggaa gaacaagcaa   3840

gcaggcagaa aagtcactct aatagagtaa agaattgaag aaaagttaag agctgccgaa   3900

atgcacagag gtgaaaatga caaaccaaat ggaatttctc ttcagagttc agaattttca   3960

gatactaagg aggaagaaag gatccactac ttcttgttct tatgaatgac tctagaaaaa   4020

tcagaatcaa gttgtgggtg gaaaaatcaa cgtggccttt gagttcagtt gttataaacc   4080

attgtgacta ttgttggtca aagtattggt acttatattg ttagtaattg catcataatt   4140

acattaccag tgttggaaaa ctaatgaaga aaacactgta attgctactc agcaaatgtg   4200

aataaaaggt gtttgcgtta ttaggatgtc tgttaagtaa tcatttaata ttattatatt   4260

ggtaatggtt gtatgtgtga tgctatgccc agaatatgaa gtatctgttt ttgaaattca   4320

ctttatttaa aagataagca gctgactggg cacggtgcct catgcctgta atcctagcac   4380

cttgggaggc tgaggcaggt ggatcaccta aggtcaggag ttcaacaaca ccagcctgac   4440

caacatggtg aaaccccatc tctactaaaa atacaaaaat cagccgggtc tcatggcagg   4500

cacctgtaat cccatctact gaggcaggag aattgcttga cccaggaggc agaggttgca   4560

gtgagccaag atcacgccat tgcactccag cctgggggac agagcaagac tctatctcca   4620

aaaaacaaaa aagataagca gctttagaat atggcgcatt caaaacagtc tcagtaacaa   4680

agacattaaa agaaaacaat ttactttcta attaaaattt tgtgtttctt aagatcaaat   4740

catataggta acttcataga cctaaattaa aagtgatttt tggctggact ggcaacaatg   4800

ttcccaatgt ctttactttt taaaaaaggc ttttcatatt taagcacata cctattttgt   4860

agacttacat tgtttaatat ttattttaat cttaatattt ttacattatt atattgcatt   4920

atttattttt tctaagttcc agaataatag tgtcattatt atagactata tgttttgaag   4980

tttgatatta taatgggata ttcatttttt gttcttttct tgactccttt ctcaagtgtg   5040

tgataaggtc tgctgataaa atatttaacc ccaagaaagt gaaaactaat ataaaattag   5100

aaagacctat ccaaattaga cagtcaattc cattaaaata agaagtgaga aaaacaatgt   5160

tgggcattga ggtgtaaatt ttgcccagat gtatacccag tgtgaaatat cttctaataa   5220

aaatatattt ggctcttatc cctgcacatg tagaggcata aaaattggta aacatgtccc   5280

gctgtgtaga actttaaaaa aaaggcattt ttgaaagtgt tgagtggcac tgataactgg   5340

tgaagcctac agccatccgc ccaaaagtct gttctgatgg cactgagttt tcattgttct   5400

ggatgtataa gtctgtgtgt caggtacagc tgggcccagc cagcttgagt cactcttgta   5460

caagcttgtt tttttctgtc ttgtgaatgc acttgataat ttaaaaataa aaatatctgt   5520

ttctctgcaa aaaaaaaa                                                 5538


<210>  784
<211>  1196
<212>  PRT
<213>  Homosapiens

<400>  784

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr 
        35                  40                  45              


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro 
    50                  55                  60                  


Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp 
65                  70                  75                  80  


Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val 
                85                  90                  95      


Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn 
            100                 105                 110         


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125             


Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu 
    130                 135                 140                 


Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys 
145                 150                 155                 160 


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175     


Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190         


Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205             


Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu 
    210                 215                 220                 


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240 


Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270         


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285             


Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr 
    290                 295                 300                 


Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320 


Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335     


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr 
            340                 345                 350         


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365             


His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380                 


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400 


Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415     


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430         


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445             


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460                 


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480 


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495     


Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510         


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525             


Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540                 


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560 


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro 
                565                 570                 575     


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590         


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605             


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620                 


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640 


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655     


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser 
            660                 665                 670         


Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr 
        675                 680                 685             


Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys 
    690                 695                 700                 


Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser 
705                 710                 715                 720 


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735     


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750         


Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile 
        755                 760                 765             


Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780                 


His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly 
785                 790                 795                 800 


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815     


Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830         


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845             


Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860                 


Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met 
865                 870                 875                 880 


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895     


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910         


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925             


Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940                 


Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960 


Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met 
                965                 970                 975     


Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser 
            980                 985                 990         


Cys Ala Ala Lys Val Asn Lys Asn  Leu Ser Phe Thr Ser  Pro Pro Ala 
        995                 1000                 1005             


Val Ser  Ser Gln Gln Ser Lys  Leu Lys Gln Ser Asn  Met Leu Thr 
    1010                 1015                 1020             


Ala Gln  Glu Ile Leu His Gln  Phe Gly Phe Thr Gln  Thr Gly Ile 
    1025                 1030                 1035             


Ile Ser  Ile Glu Arg Lys Pro  Cys Asn His Gln Val  Asp Thr Ala 
    1040                 1045                 1050             


Pro Thr  Val Val Ala Leu Tyr  Asp Tyr Thr Ala Asn  Arg Ser Asp 
    1055                 1060                 1065             


Glu Leu  Thr Ile His Arg Gly  Asp Ile Ile Arg Val  Phe Phe Lys 
    1070                 1075                 1080             


Asp Asn  Glu Asp Trp Trp Tyr  Gly Ser Ile Gly Lys  Gly Gln Glu 
    1085                 1090                 1095             


Gly Tyr  Phe Pro Ala Asn His  Val Ala Ser Glu Thr  Leu Tyr Gln 
    1100                 1105                 1110             


Glu Leu  Pro Pro Glu Ile Lys  Glu Arg Ser Pro Pro  Leu Ser Pro 
    1115                 1120                 1125             


Glu Glu  Lys Thr Lys Ile Glu  Lys Ser Pro Ala Pro  Gln Lys Gln 
    1130                 1135                 1140             


Ser Ile  Asn Lys Asn Lys Ser  Gln Asp Phe Arg Leu  Gly Ser Glu 
    1145                 1150                 1155             


Ser Met  Thr His Ser Glu Met  Arg Lys Glu Gln Ser  His Glu Asp 
    1160                 1165                 1170             


Gln Gly  His Ile Met Asp Thr  Arg Met Arg Lys Asn  Lys Gln Ala 
    1175                 1180                 1185             


Gly Arg  Lys Val Thr Leu Ile  Glu 
    1190                 1195     


<210>  785
<211>  757
<212>  DNA
<213>  Homosapiens

<400>  785
atggcgaccg atgcgtcccg cgaggagggg ccgtgcggcg cctgcccggg ggccctcagg     60

ccgcaggcgg gcgcgagctt cagggaactt agggggctcc cgcctccccg gccacgcgag    120

cgggaacagt ctcctccact cggagcggcg ccatcttcag ctctgagtca ccagggctgg    180

aaaaatacta gatgcgctac tcgtggactc gtgaatacac tcgtgaatac aggccatttc    240

ctgtacctac agccacccgc tccactcatc atgccttacc tggatgatgc agaagtccct    300

ggaaacagaa ggtctcaccc ttctttatct ttctcatggc tttccaaggc tctttatcat    360

gttactttcc tgctcagaat tctttaatga cttgcctcaa tgaccagata catgtgatct    420

acagtcagcc ttccagcctc atcattcctc ttccatttcc tccccagaaa cactgtactt    480

tatgaagctc ctccaagact gctctctcag cagctgggac ccggtcttgg aatcttagtg    540

tcaactatga tgaatcacca acactaacaa aaacattatc ttttattggg ttaaatagtt    600

tctactcttc ccaagactgg gaactgatgt aacaggcttc gtgctttctt cccaacaaat    660

tgattctgtg tggtcagctc ctgtcatgat gatagaaccc cctgtattga tttatactta    720

ggggtatatc aatgtcagtc taaacttgtc ctaccta                             757


<210>  786
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  786

Met Ala Thr Asp Ala Ser Arg Glu Glu Gly Pro Cys Gly Ala Cys Pro 
1               5                   10                  15      


Gly Ala Leu Arg Pro Gln Ala Gly Ala Ser Phe Arg Glu Leu Arg Gly 
            20                  25                  30          


Leu Pro Pro Pro Arg Pro Arg Glu Arg Glu Gln Ser Pro Pro Leu Gly 
        35                  40                  45              


Ala Ala Pro Ser Ser Ala Leu Ser His Gln Gly Trp Lys Asn Thr Arg 
    50                  55                  60                  


Cys Ala Thr Arg Gly Leu Val Asn Thr Leu Val Asn Thr Gly His Phe 
65                  70                  75                  80  


Leu Tyr Leu Gln Pro Pro Ala Pro Leu Ile Met Pro Tyr Leu Asp Asp 
                85                  90                  95      


Ala Glu Val Pro Gly Asn Arg Arg Ser His Pro Ser Leu Ser Phe Ser 
            100                 105                 110         


Trp Leu Ser Lys Ala Leu Tyr His Val Thr Phe Leu Leu Arg Ile Leu 
        115                 120                 125             


<210>  787
<211>  1290
<212>  DNA
<213>  Homosapiens

<400>  787
gttacaatct gaagtgggag cggcggtgaa ggtcctgggt gaggtagggg tggatggtgc     60

ttgccgcgta tcatggctgc ctccggaaaa ctcagcactt gccgtctccc tccgttgccc    120

acgattcgag aaatcattaa gttgttaaga ctgcaagcag cgaacgagct atcacagaat    180

ttcctcctgg acttgaggct gacagataag attgtaagga aagctggcaa tctgacaaat    240

gcttatgttt acgaagtggg ccctgggcca gggggaatca caagatctat tcttaatgcc    300

gacgtcgctg aacttctggt ggttgaaaag gacactcgat ttattcctgg attacagatg    360

ctttctgatg cagcacctgg gaaactgaga attgttcatg gagatgtctt gacatttaag    420

gtagaaaagg ctttttcaga aagtcttaaa agaccctggg aagatgatcc tccaaatgta    480

catattattg gaaatctgcc ttttagtgtt tcaactccac tgattatcaa gtggcttgaa    540

aatatttcct gtagagatgg accttttgtt tatggcagaa ctcagatgac tttgactttt    600

caaaaggaag tggcagagag acttgcagcc aatacaggaa gcaaacagcg tagtcgcctc    660

tctgttatgg ctcagtacct ctgcaatgtt cgacacatct ttacaattcc aggacaagct    720

tttgtcccca aaccagaggt ggacgtgggc gtggtgcact tcactccctt gatacagccc    780

aagatagagc agccattcaa gctggtggaa aaagtggttc agaatgtatt tcagttccga    840

aggaaatact gccatcgagg gctcagaatg ttattccctg aagcgcagcg cttggaaagc    900

acgggcaggc tgttagagtt ggcagacata gaccctactc ttcggccccg ccagctctcc    960

atctcacact ttaagagcct ctgtgatgta tacagaaaaa tgtgtgatga agacccacaa   1020

ctctttgcat ataatttcag agaagaactc aagcgaagaa aaagcaaaaa tgaagaaaaa   1080

gaagaggatg acgcagagaa ttacagactc tagctgctgc ctgggggcga gcagcctacc   1140

agatgtcgat ttgcctacgt ggagcttctt atataggtac tcttttgtct ttacagaatg   1200

acgatacaaa tgccaatgac cagatgtgac ttattttcct tttactatac agcttggcag   1260

agaaaataaa tatcatcaaa taagaaaaaa                                    1290


<210>  788
<211>  346
<212>  PRT
<213>  Homosapiens

<400>  788

Met Ala Ala Ser Gly Lys Leu Ser Thr Cys Arg Leu Pro Pro Leu Pro 
1               5                   10                  15      


Thr Ile Arg Glu Ile Ile Lys Leu Leu Arg Leu Gln Ala Ala Asn Glu 
            20                  25                  30          


Leu Ser Gln Asn Phe Leu Leu Asp Leu Arg Leu Thr Asp Lys Ile Val 
        35                  40                  45              


Arg Lys Ala Gly Asn Leu Thr Asn Ala Tyr Val Tyr Glu Val Gly Pro 
    50                  55                  60                  


Gly Pro Gly Gly Ile Thr Arg Ser Ile Leu Asn Ala Asp Val Ala Glu 
65                  70                  75                  80  


Leu Leu Val Val Glu Lys Asp Thr Arg Phe Ile Pro Gly Leu Gln Met 
                85                  90                  95      


Leu Ser Asp Ala Ala Pro Gly Lys Leu Arg Ile Val His Gly Asp Val 
            100                 105                 110         


Leu Thr Phe Lys Val Glu Lys Ala Phe Ser Glu Ser Leu Lys Arg Pro 
        115                 120                 125             


Trp Glu Asp Asp Pro Pro Asn Val His Ile Ile Gly Asn Leu Pro Phe 
    130                 135                 140                 


Ser Val Ser Thr Pro Leu Ile Ile Lys Trp Leu Glu Asn Ile Ser Cys 
145                 150                 155                 160 


Arg Asp Gly Pro Phe Val Tyr Gly Arg Thr Gln Met Thr Leu Thr Phe 
                165                 170                 175     


Gln Lys Glu Val Ala Glu Arg Leu Ala Ala Asn Thr Gly Ser Lys Gln 
            180                 185                 190         


Arg Ser Arg Leu Ser Val Met Ala Gln Tyr Leu Cys Asn Val Arg His 
        195                 200                 205             


Ile Phe Thr Ile Pro Gly Gln Ala Phe Val Pro Lys Pro Glu Val Asp 
    210                 215                 220                 


Val Gly Val Val His Phe Thr Pro Leu Ile Gln Pro Lys Ile Glu Gln 
225                 230                 235                 240 


Pro Phe Lys Leu Val Glu Lys Val Val Gln Asn Val Phe Gln Phe Arg 
                245                 250                 255     


Arg Lys Tyr Cys His Arg Gly Leu Arg Met Leu Phe Pro Glu Ala Gln 
            260                 265                 270         


Arg Leu Glu Ser Thr Gly Arg Leu Leu Glu Leu Ala Asp Ile Asp Pro 
        275                 280                 285             


Thr Leu Arg Pro Arg Gln Leu Ser Ile Ser His Phe Lys Ser Leu Cys 
    290                 295                 300                 


Asp Val Tyr Arg Lys Met Cys Asp Glu Asp Pro Gln Leu Phe Ala Tyr 
305                 310                 315                 320 


Asn Phe Arg Glu Glu Leu Lys Arg Arg Lys Ser Lys Asn Glu Glu Lys 
                325                 330                 335     


Glu Glu Asp Asp Ala Glu Asn Tyr Arg Leu 
            340                 345     


<210>  789
<211>  1239
<212>  DNA
<213>  Homosapiens

<400>  789
aaaagttcga agtgggatga tcacgggcag acctgggtgg ttgggaacag gaagcatatg     60

gcatcttgca ggctataggc accacaaaat ggaacgcagg aggacagggg cttgggagag    120

ccacttcact gtcgggtaaa acaacggagc aagatgagtg cctccggatg cttggtttcc    180

ccaccctcca gtgtctgctt gctcttcaag tacctccacc aagctaatga cagtccactt    240

taggacatca cgggcctcga ggttacaact ttcccaggct ttgttatttg gttctctact    300

gcacagaaat agatagaatt ctgacagcca tcattgttaa acatcaggat tttctaagag    360

gacagactta acagtaacat catggcctca gcaggactcc agctccttgc tttcatcctg    420

gccttatctg gggtctctgg agtgctcaca gccactctgc tgcccaactg gaaggtgaat    480

gtggatgtgg actccaacat cataacagcc attgtacagc tgcacgggct ctggatggac    540

tgtacgtggt acagcactgg gatgttcagc tgtgccctga aacactccat tctgtccctc    600

cccatccacg tgcaggctgc gagagccacc atggtcctgg cgtgtgttct gtctgctttg    660

gggatctgca cttccacagt aggaatgaaa tgtactcgct taggagggga cagagaaacc    720

aagagccatg cttcctttgc tggaggagtc tgtttcatgt ctgcaggaat ctctagttta    780

atctcgacag tgtggtacac aaaggagatc atagcaaact ttctggatct gacagttcca    840

gaaagcaaca aacatgaacc tggaggagct atctatatcg gattcatttc tgcaatgctg    900

ttgtttatct ctggcatgat tttctgcacc tcctgtataa aaaggaatcc agaagctaga    960

ctcgacccac ccacacagca gcctatctct aacacacagc tcgagaacaa ttccacacac   1020

aatctgaagg attatgtgta aataactgag taatgcatat gaaatggaac ttttgggtgc   1080

caaatgggac ttttagatta aaaaaaaatc agaattatgc ttaactttcc ctacaaagaa   1140

agtagaatgt aaaatacttt aacaactaca aagtagttta aaatgccaat aaaactatca   1200

tatacaagta aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          1239


<210>  790
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  790

Met Ala Ser Ala Gly Leu Gln Leu Leu Ala Phe Ile Leu Ala Leu Ser 
1               5                   10                  15      


Gly Val Ser Gly Val Leu Thr Ala Thr Leu Leu Pro Asn Trp Lys Val 
            20                  25                  30          


Asn Val Asp Val Asp Ser Asn Ile Ile Thr Ala Ile Val Gln Leu His 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Thr Trp Tyr Ser Thr Gly Met Phe Ser Cys 
    50                  55                  60                  


Ala Leu Lys His Ser Ile Leu Ser Leu Pro Ile His Val Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Thr Met Val Leu Ala Cys Val Leu Ser Ala Leu Gly Ile Cys 
                85                  90                  95      


Thr Ser Thr Val Gly Met Lys Cys Thr Arg Leu Gly Gly Asp Arg Glu 
            100                 105                 110         


Thr Lys Ser His Ala Ser Phe Ala Gly Gly Val Cys Phe Met Ser Ala 
        115                 120                 125             


Gly Ile Ser Ser Leu Ile Ser Thr Val Trp Tyr Thr Lys Glu Ile Ile 
    130                 135                 140                 


Ala Asn Phe Leu Asp Leu Thr Val Pro Glu Ser Asn Lys His Glu Pro 
145                 150                 155                 160 


Gly Gly Ala Ile Tyr Ile Gly Phe Ile Ser Ala Met Leu Leu Phe Ile 
                165                 170                 175     


Ser Gly Met Ile Phe Cys Thr Ser Cys Ile Lys Arg Asn Pro Glu Ala 
            180                 185                 190         


Arg Leu Asp Pro Pro Thr Gln Gln Pro Ile Ser Asn Thr Gln Leu Glu 
        195                 200                 205             


Asn Asn Ser Thr His Asn Leu Lys Asp Tyr Val 
    210                 215                 


<210>  791
<211>  2044
<212>  DNA
<213>  Homosapiens

<400>  791
caaagacaaa ataatttact agggaagccc ttactaacga cccaacatcc agacacaggt     60

gagggagaag aaatttcctg acagccgaag agcaacaagt atcatgatgg ggtgctggat    120

tttgaatgag ggtctctcca ccatattagt actctcatgg ctgggaataa atttttatct    180

gtttattgac acgttctact ggtatgaaga ggaggagtct ttccattaca cacgagttat    240

tttgggttca acactggctt gggcacgagc atccgcactg tgcctgaatt ttaactgcat    300

gctaattcta atacctgtca gtcgaaacct tatttcattc ataagaggaa caagtatttg    360

ctgcagagga ccgtggagga ggcaattaga caaaaacctc agatttcaca aactggtcgc    420

ctatgggata gctgttaatg caaccatcca catcgtggcg catttcttca acctggaacg    480

ctaccactgg agccagtccg aggaggccca gggacttctg gccgcacttt ccaagctggg    540

caacacccct aacgagagct acctcaaccc tgtccggacc ttccccacaa acacaaccac    600

tgaattgcta aggacaatag caggcgtcac cggtctggtg atctctctgg ctttagtctt    660

gatcatgacc tcgtcaactg agttcatcag acaggcctcc tatgagttgt tctggtacac    720

acaccatgtt ttcatcgtct tctttctcag cctggccatc catgggacgg gtcggattgt    780

tcgaggccaa acccaagaca gtctctctct gcacaacatc accttctgta gagaccgcta    840

tgcagaatgg cagacagtgg cccaatgccc cgtgcctcaa ttttctggca aggaaccctc    900

ggcttggaaa tggattttag gccctgtggt cttgtatgca tgtgaaagaa taattaggtt    960

ctggcgattt caacaagaag ttgtcattac caaggtggta agccacccct ctggagtcct   1020

ggaacttcac atgaaaaagc gtggctttaa aatggcgcca gggcagtaca tcttggtgca   1080

gtgcccagcc atatcttcgc tggagtggca ccccttcacc cttacctctg ccccccagga   1140

agactttttc agcgtgcaca tccgggcagc aggagactgg acagcagcgc tactggaggc   1200

ctttggggca gagggacagg ccctccagga gccctggagc ctgccaaggc tggcagtgga   1260

cgggcccttt ggaactgccc tgacagatgt atttcactac ccagtgtgtg tgtgcgttgc   1320

cgcggggatc ggagtcactc ccttcgctgc tcttctgaaa tctatatggt acaaatgcag   1380

tgaggcacag accccactga agctgagcaa ggtgtatttc tactggattt gccgggatgc   1440

aagagctttt gagtggtttg ctgatctctt actctccctg gaaacacgga tgagtgagca   1500

ggggaaaact cactttctga gttatcatat atttcttacc ggctgggatg aaaatcaggc   1560

tcttcacata gctttacact gggacgaaaa tactgacgtg attacaggct taaagcagaa   1620

gaccttctat gggaggccca actggaacaa tgagttcaag cagattgcct acaatcaccc   1680

cagcagcagt attggcgtgt tcttctgtgg acctaaagct ctctcgagga cacttcaaaa   1740

gatgtgccac ttgtattcat cagctgaccc cagaggtgtt catttctatt acaacaagga   1800

gagcttctag actttggagg tcaagtccag gcattgtgtt ttcaatcaag ttattgattc   1860

caaagaactc caccaggaat tcctgtgacg gcctgttgat atgagctccc agttgggaac   1920

tggtgaataa taattaacta ttgtgaacag tacactatac catacttcct tagcttataa   1980

ataacatgtc atatacaaca gaacaaaaac atttactgaa attaaaatat attatgtttc   2040

tcca                                                                2044


<210>  792
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  792

Met Met Gly Cys Trp Ile Leu Asn Glu Gly Leu Ser Thr Ile Leu Val 
1               5                   10                  15      


Leu Ser Trp Leu Gly Ile Asn Phe Tyr Leu Phe Ile Asp Thr Phe Tyr 
            20                  25                  30          


Trp Tyr Glu Glu Glu Glu Ser Phe His Tyr Thr Arg Val Ile Leu Gly 
        35                  40                  45              


Ser Thr Leu Ala Trp Ala Arg Ala Ser Ala Leu Cys Leu Asn Phe Asn 
    50                  55                  60                  


Cys Met Leu Ile Leu Ile Pro Val Ser Arg Asn Leu Ile Ser Phe Ile 
65                  70                  75                  80  


Arg Gly Thr Ser Ile Cys Cys Arg Gly Pro Trp Arg Arg Gln Leu Asp 
                85                  90                  95      


Lys Asn Leu Arg Phe His Lys Leu Val Ala Tyr Gly Ile Ala Val Asn 
            100                 105                 110         


Ala Thr Ile His Ile Val Ala His Phe Phe Asn Leu Glu Arg Tyr His 
        115                 120                 125             


Trp Ser Gln Ser Glu Glu Ala Gln Gly Leu Leu Ala Ala Leu Ser Lys 
    130                 135                 140                 


Leu Gly Asn Thr Pro Asn Glu Ser Tyr Leu Asn Pro Val Arg Thr Phe 
145                 150                 155                 160 


Pro Thr Asn Thr Thr Thr Glu Leu Leu Arg Thr Ile Ala Gly Val Thr 
                165                 170                 175     


Gly Leu Val Ile Ser Leu Ala Leu Val Leu Ile Met Thr Ser Ser Thr 
            180                 185                 190         


Glu Phe Ile Arg Gln Ala Ser Tyr Glu Leu Phe Trp Tyr Thr His His 
        195                 200                 205             


Val Phe Ile Val Phe Phe Leu Ser Leu Ala Ile His Gly Thr Gly Arg 
    210                 215                 220                 


Ile Val Arg Gly Gln Thr Gln Asp Ser Leu Ser Leu His Asn Ile Thr 
225                 230                 235                 240 


Phe Cys Arg Asp Arg Tyr Ala Glu Trp Gln Thr Val Ala Gln Cys Pro 
                245                 250                 255     


Val Pro Gln Phe Ser Gly Lys Glu Pro Ser Ala Trp Lys Trp Ile Leu 
            260                 265                 270         


Gly Pro Val Val Leu Tyr Ala Cys Glu Arg Ile Ile Arg Phe Trp Arg 
        275                 280                 285             


Phe Gln Gln Glu Val Val Ile Thr Lys Val Val Ser His Pro Ser Gly 
    290                 295                 300                 


Val Leu Glu Leu His Met Lys Lys Arg Gly Phe Lys Met Ala Pro Gly 
305                 310                 315                 320 


Gln Tyr Ile Leu Val Gln Cys Pro Ala Ile Ser Ser Leu Glu Trp His 
                325                 330                 335     


Pro Phe Thr Leu Thr Ser Ala Pro Gln Glu Asp Phe Phe Ser Val His 
            340                 345                 350         


Ile Arg Ala Ala Gly Asp Trp Thr Ala Ala Leu Leu Glu Ala Phe Gly 
        355                 360                 365             


Ala Glu Gly Gln Ala Leu Gln Glu Pro Trp Ser Leu Pro Arg Leu Ala 
    370                 375                 380                 


Val Asp Gly Pro Phe Gly Thr Ala Leu Thr Asp Val Phe His Tyr Pro 
385                 390                 395                 400 


Val Cys Val Cys Val Ala Ala Gly Ile Gly Val Thr Pro Phe Ala Ala 
                405                 410                 415     


Leu Leu Lys Ser Ile Trp Tyr Lys Cys Ser Glu Ala Gln Thr Pro Leu 
            420                 425                 430         


Lys Leu Ser Lys Val Tyr Phe Tyr Trp Ile Cys Arg Asp Ala Arg Ala 
        435                 440                 445             


Phe Glu Trp Phe Ala Asp Leu Leu Leu Ser Leu Glu Thr Arg Met Ser 
    450                 455                 460                 


Glu Gln Gly Lys Thr His Phe Leu Ser Tyr His Ile Phe Leu Thr Gly 
465                 470                 475                 480 


Trp Asp Glu Asn Gln Ala Leu His Ile Ala Leu His Trp Asp Glu Asn 
                485                 490                 495     


Thr Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Phe Tyr Gly Arg Pro 
            500                 505                 510         


Asn Trp Asn Asn Glu Phe Lys Gln Ile Ala Tyr Asn His Pro Ser Ser 
        515                 520                 525             


Ser Ile Gly Val Phe Phe Cys Gly Pro Lys Ala Leu Ser Arg Thr Leu 
    530                 535                 540                 


Gln Lys Met Cys His Leu Tyr Ser Ser Ala Asp Pro Arg Gly Val His 
545                 550                 555                 560 


Phe Tyr Tyr Asn Lys Glu Ser Phe 
                565             


<210>  793
<211>  6880
<212>  DNA
<213>  Homosapiens

<400>  793
agccttgagt gtcattcaag ggacagcaca acctcatcca agctctccta cctctgccca     60

gccgtccctc tcatcctccc cattcctcgt ccacactcca tccaaagaag agggaaagca    120

ccgaatagag gggggcgaag gcaaagtctg ctgttcttcc ccctgggccc ccttgctcct    180

ccatcctcat tctctcacca ccagcccccc taaccccaag gagcccagga actgaggcga    240

ctcgccccac tgccatgtcc aaaagcttga aaaagaaaag ccactggact agcaaagtcc    300

atgagagtgt cattggcagg aacccggagg gccagctggg ctttgaactg aaggggggcg    360

ccgagaatgg acagttcccc tacctggggg aggtgaagcc cggcaaggtg gcctatgaga    420

gcggcagcaa attggtgtcg gaggagctgc tgctggaggt gaacgagacc cccgtggcgg    480

ggctcaccat cagggacgtg ctggccgtga tcaaacactg caaggacccc ctccggctca    540

agtgtgtcaa gcaaggagga attgttgata aagaccttcg tcactacctc aacttacgat    600

ttcaaaaggg ttctgtggac catgagcttc agcaaatcat tcgtgacaac ctctacctcc    660

gcacggtgcc atgcaccaca aggccacata aggagggtga ggtccctgga gtggattata    720

ttttcatcac tgttgaagat tttatggaat tggagaaaag tggtgctctc ctagaaagtg    780

ggacttatga agacaattac tacggtaccc caaagccgcc agcagaacca gcaccattat    840

tgttaaatgt aacagaccag atacttccag gagccactcc aagtgctgaa ggaaaacgga    900

agaggaataa atcagtgagc aacatggaga aagccagtat agagcctcct gaggaggaag    960

aggaagagag gcctgtggtc aatggaaatg gagtagtagt aacaccagaa tccagtgaac   1020

atgaagacaa aagtgcaggt gcctcagggg agatgccctc ccagccttat cctgcaccag   1080

tgtacagtca gcctgaggag ctgaaggagc agatggatga cacaaagcca actaaacctg   1140

aagacaatga ggaaccagac ccattgcctg ataactggga aatggcctat acagagaagg   1200

gcgaagtcta cttcattgac cataacacaa agacaacatc atggctggat ccacgacttg   1260

cgaaaaaggc taaacctcca gaagagtgca aagaaaatga gcttccatat ggctgggaaa   1320

aaatcgatga tcccatttat ggcacttatt atgttgacca cataaataga agaacacagt   1380

ttgaaaatcc tgtcctggaa gcaaaaagga agctacagca acataacatg ccccacacag   1440

aacttggaac aaagcccctg caggccccag gtttccgaga aaaaccactc ttcacccggg   1500

atgcatccca gttgaaggga acattcctca gcaccaccct aaaaaagagc aacatgggct   1560

ttggatttac catcattggt ggagacgagc ctgatgagtt tctgcaggtg aaaagtgtga   1620

ttccggatgg gcctgcagca caggatggaa aaatggaaac aggtgatgtc attgtctata   1680

ttaatgaagt ttgtgtcctt ggacacactc atgcagatgt tgtcaaactt ttccagtctg   1740

ttcctattgg tcagagtgtc aacctggtgt tgtgtcgtgg ctaccctttg ccctttgatc   1800

ctgaagaccc tgctaacagc atggtgccac cccttgcaat aatggagagg ccacctccag   1860

tgatggtcaa tggaagacac aactatgaaa catatttgga gtacatttct cggacctcac   1920

agtcagttcc agatataaca gatcggccgc ctcattctct gcactccatg ccaactgatg   1980

gtcagctaga cggcacgtat ccaccgcccg tccatgatga caatgtgtct atggcttcat   2040

ctggggccac ccaagctgaa cttatgacct taaccattgt gaaaggtgcc cagggcttcg   2100

gcttcactat tgccgacagt cctacaggac agcgggtgaa acaaatactt gacattcagg   2160

gatgccctgg cctgtgtgaa ggcgacctca ttgttgagat caaccagcag aatgtacaga   2220

acctgagcca tacagaagta gtggatatac ttaaggactg tcccattgga agtgaaactt   2280

ctttgattat ccatcgagga ggtttctttt ctccatggaa aactccaaag cctataatgg   2340

accgatggga gaatcaaggc agtcctcaaa cgagtttatc tgctccggcc ataccgcaga   2400

acctgccctt cccacctgcc cttcacagga gctcctttcc tgactcaaca gaggcctttg   2460

acccacggaa gcctgatcca tatgagctct acgagaaatc tagggccatt tatgaaagta   2520

ggcaacaagt gccacccagg accagttttc gaatggattc ctctggtcca gattataagg   2580

aattggatgt tcatcttcgg aggatggagt ctggatttgg cttcagaatc ctcgggggag   2640

atgagcctgg acagcctatt ttgattggag ctgtcattgc catgggctca gccgacagag   2700

atggccgcct tcacccagga gatgagcttg tgtatgttga tgggattcca gtagccggca   2760

aaacccaccg ctatgtcatc gacctcatgc accacgcagc ccgcaatggg caggtcaacc   2820

tcactgtgag aagaaaggtg ctatgtggag gggagccctg cccagagaac gggagaagtc   2880

caggctctgt atccacccac cacagctctc cacgcagtga ctacgcaacc tacaccaaca   2940

gcaaccacgc tgcccccagt agcaatgcct ctccccctga aggcttcgcc tcccacagcc   3000

tgcagaccag tgatgtggtc attcaccgca aagagaatga gggcttcggc tttgtcatca   3060

tcagctccct gaacaggcct gagtctggat ccactataac tgtgccccat aaaatcggac   3120

gcatcattga tgggagtcct gcagatcgct gtgcaaaact aaaagtggga gaccggatcc   3180

tagcagtgaa tggccagtct atcatcaaca tgcctcacgc tgacatcgtg aagctcatca   3240

aggatgcagg tcttagtgtc acccttcgca tcattcctca ggaggagctc aacagcccca   3300

cctcggcacc cagctcagag aagcagagtc ccatggcgca gcagagtccc ctggcacagc   3360

agagtcccct ggcccagcca agcccagcca cccccaacag ccccatcgcc cagccagcac   3420

cacctcaacc acttcagctg caaggacacg aaaatagtta caggtcggaa gtgaaagcaa   3480

ggcaagatgt gaaaccagac atccgacagc ctccattcac agactacagg cagcccccgc   3540

tggattacag gcaaccccca ggaggggact accagcagcc cccacccttg gactacaggc   3600

agcctcccct actggactac aggcagcact cccccgacac caggcagtac cctctgtcgg   3660

actacagaca accccaggat tttgattatt tcactgtgga catggagaaa ggagccaaag   3720

gatttggatt cagcattcgt ggaggaaggg aatacaaaat ggatttgtat gtgttgagac   3780

tggcagaaga tggaccagca ataaggaatg ggaggatgag ggtaggagat caaatcattg   3840

aaatcaatgg ggaaagcaca agggacatga cacatgccag agcaatagaa ctcatcaaat   3900

ctggaggaag acgagtgagg ctgctgctca agagaggcac gggacaggtc ccagaatatg   3960

acgaacccgc cccctggagt tctcccgctg ccgccgcccc aggtctgccg gaagtaggcg   4020

tctccctgga cgacggcctc gctccattct ctccatcaca tccagcccca ccctccgacc   4080

cttcccacca gataagccca ggcccaactt gggatatcaa acgggaacac gacgttagga   4140

aaccaaagga gctttcagcc tgcggccaga agaagcagcg cctcggggag cagagggagc   4200

gctcggcgag tccgcagagg gccgcgcggc cgaggctcga ggaggcgccc ggcggccagg   4260

ggcggcccga ggccggcagg cccgcctcgg aggccagggc gcccgggctc gcggcggcag   4320

acgcggcgga cgcggcgcgg gcgggcggga aggaggcgcc ccgtgcggcg gcgggctccg   4380

agctctgccg gcgcgaaggc ccgggggctg cgccggcgtt tgccggcccg ggcggcggcg   4440

gcagcggcgc gctggaggcc gagggcaggg cgggtgcgcg cgcgggtccc cggccgggcc   4500

cgcgaccccc ggggggcgcc ccggcgcgca aggccgccgt cgcgccgggg ccctggaagg   4560

tgccgggttc tgacaagctg cccagcgtcc tcaaacccgg cgcctcggcc gccagcagat   4620

gagccgcgcg gccacggcca acccgcccgc cccggcgcag gcagttcttc ttaggttccg   4680

tctcacggcg ttttaattta ttttcactgt cacacgcata gatccacgag gcaccaaggc   4740

ctgggagcat cgacgtgaag tcccacgtgt ccggtgtgct tgggcggcat cgcatcaacg   4800

cgcagaccta aactgatcct aaagcccccg gttcccttgt gggggctttg gcagctatgg   4860

aagaaccaaa ataacgtgaa gaacatcaca gagagacagt gcagtgtagc tttagtttaa   4920

gaaaaaaaaa tattcctccc cactgcatga aggacttgga tgtcatccaa actttatatc   4980

aagaaacagg acaaagttaa gagcaatcac aaactggaat atcgccttaa aaatcaaact   5040

gcacggagca agctgaaact gagacaagat tatatctttt aattgatcta aagcgttgta   5100

aataaattgt tctcgacata tctagacagg ggttaaaggg tttctttgac acattcggaa   5160

ccgttcaccc atgacatgtt tccatggctc acccttggca tccatcctcg gtgttagcag   5220

cagcgttccc tgcctcctgc aggatgactt agaaatctag tgagtttctt ggtgtgatgc   5280

catttttatt gccctttctg tgatcaaatc atatttctgt acattttcag tggtagaaaa   5340

aaaaggtttt aaaaattgta tcctagggaa cagtttgcca taagtcagaa ttttgcagtt   5400

tagctcatag atcttaattg gtttttctct aaaatatgaa ttttataatt gaaggaccac   5460

aatttgttta atcaagatag gcaacgctgc agttccttta tgaagaggct tttctgtcgt   5520

cccaggctag cagagatgga tagcttcttt gtcagcaatg tgatttcact tattttattg   5580

tcttatttta aaccctgtct ccatgacttc atttgcactt tgacagagca gaggcagagt   5640

atttgtctta tatttctcag attataatat taaaaaatta caatcaattt attttcatta   5700

aagaacgtga gtctttttag cattcctttc tgcttatcct tctttcctta ccctttgtcc   5760

ttttgtttcc attagttttc tttcgtcttg tattccttgc cactttattt tgttagcaac   5820

ttctagatgt ttatcttcat ggatctatga ttgacctcct agtaaaattc taagtcttgc   5880

ctttcttccc tgctgtttta gcatttcttt gtaaaatgtt agcttcaatt aattagccat   5940

tggtacttac tgtagctaca catattaaaa ggcaaagtgt ttctgaaggc aatttctttt   6000

taatatgccc gaatgaatga ggcttcatcc tttccatatt cttactcttt acaggagttc   6060

aaatgcaaat aagctccacc tccctgcact tgtagtctaa aaagtaaaag gggcgatcag   6120

gtccatctca aaggtcacac gtaatagcct ccctgggctg atcattccct ctccttgtaa   6180

ttgcagtatc ctgagtagca gtttaatttt catcaaacat cggagtagtt tagttgtttg   6240

acaggaggag aataaggctg aaagcctcaa gtgaaggatc ttgcagcttg taaaagcaat   6300

ttccaaaaat gaaacccatt catcgtaaac aaaagcacaa acacttgtag cagtttataa   6360

tgcttttggt ttaatctcaa ttagtctttc tcccctggac tagaaatcca gtatagtttg   6420

ccattaattt attgaatctg gttttggaca atgcttctgt agtgtagctg cacgtcctgg   6480

tactgtatcc tctgacttta ttttccatgt attacaaaag gaaaaaaaaa ttgagattac   6540

actggcataa actctagttt gcacagttca cagctactac ttgtgcagta attgctttat   6600

gcggctgtaa tccataacct gtgaagacag cacatcatct aaatcccatt ccaaataata   6660

tttgtgtagt gttagctgtg aatttaccct gtacagctgt atctctataa atataattcc   6720

atgtattaat agtcacagaa agactgtaag tgagcaacta tttttatgaa acgtaccact   6780

atggataaat taacttttac agaaatcttg tttactgtat gatattctaa aacactgtca   6840

aataaaatat atatccaaaa atcttttctt tttccaacta                         6880


<210>  794
<211>  1455
<212>  PRT
<213>  Homosapiens

<400>  794

Met Ser Lys Ser Leu Lys Lys Lys Ser His Trp Thr Ser Lys Val His 
1               5                   10                  15      


Glu Ser Val Ile Gly Arg Asn Pro Glu Gly Gln Leu Gly Phe Glu Leu 
            20                  25                  30          


Lys Gly Gly Ala Glu Asn Gly Gln Phe Pro Tyr Leu Gly Glu Val Lys 
        35                  40                  45              


Pro Gly Lys Val Ala Tyr Glu Ser Gly Ser Lys Leu Val Ser Glu Glu 
    50                  55                  60                  


Leu Leu Leu Glu Val Asn Glu Thr Pro Val Ala Gly Leu Thr Ile Arg 
65                  70                  75                  80  


Asp Val Leu Ala Val Ile Lys His Cys Lys Asp Pro Leu Arg Leu Lys 
                85                  90                  95      


Cys Val Lys Gln Gly Gly Ile Val Asp Lys Asp Leu Arg His Tyr Leu 
            100                 105                 110         


Asn Leu Arg Phe Gln Lys Gly Ser Val Asp His Glu Leu Gln Gln Ile 
        115                 120                 125             


Ile Arg Asp Asn Leu Tyr Leu Arg Thr Val Pro Cys Thr Thr Arg Pro 
    130                 135                 140                 


His Lys Glu Gly Glu Val Pro Gly Val Asp Tyr Ile Phe Ile Thr Val 
145                 150                 155                 160 


Glu Asp Phe Met Glu Leu Glu Lys Ser Gly Ala Leu Leu Glu Ser Gly 
                165                 170                 175     


Thr Tyr Glu Asp Asn Tyr Tyr Gly Thr Pro Lys Pro Pro Ala Glu Pro 
            180                 185                 190         


Ala Pro Leu Leu Leu Asn Val Thr Asp Gln Ile Leu Pro Gly Ala Thr 
        195                 200                 205             


Pro Ser Ala Glu Gly Lys Arg Lys Arg Asn Lys Ser Val Ser Asn Met 
    210                 215                 220                 


Glu Lys Ala Ser Ile Glu Pro Pro Glu Glu Glu Glu Glu Glu Arg Pro 
225                 230                 235                 240 


Val Val Asn Gly Asn Gly Val Val Val Thr Pro Glu Ser Ser Glu His 
                245                 250                 255     


Glu Asp Lys Ser Ala Gly Ala Ser Gly Glu Met Pro Ser Gln Pro Tyr 
            260                 265                 270         


Pro Ala Pro Val Tyr Ser Gln Pro Glu Glu Leu Lys Glu Gln Met Asp 
        275                 280                 285             


Asp Thr Lys Pro Thr Lys Pro Glu Asp Asn Glu Glu Pro Asp Pro Leu 
    290                 295                 300                 


Pro Asp Asn Trp Glu Met Ala Tyr Thr Glu Lys Gly Glu Val Tyr Phe 
305                 310                 315                 320 


Ile Asp His Asn Thr Lys Thr Thr Ser Trp Leu Asp Pro Arg Leu Ala 
                325                 330                 335     


Lys Lys Ala Lys Pro Pro Glu Glu Cys Lys Glu Asn Glu Leu Pro Tyr 
            340                 345                 350         


Gly Trp Glu Lys Ile Asp Asp Pro Ile Tyr Gly Thr Tyr Tyr Val Asp 
        355                 360                 365             


His Ile Asn Arg Arg Thr Gln Phe Glu Asn Pro Val Leu Glu Ala Lys 
    370                 375                 380                 


Arg Lys Leu Gln Gln His Asn Met Pro His Thr Glu Leu Gly Thr Lys 
385                 390                 395                 400 


Pro Leu Gln Ala Pro Gly Phe Arg Glu Lys Pro Leu Phe Thr Arg Asp 
                405                 410                 415     


Ala Ser Gln Leu Lys Gly Thr Phe Leu Ser Thr Thr Leu Lys Lys Ser 
            420                 425                 430         


Asn Met Gly Phe Gly Phe Thr Ile Ile Gly Gly Asp Glu Pro Asp Glu 
        435                 440                 445             


Phe Leu Gln Val Lys Ser Val Ile Pro Asp Gly Pro Ala Ala Gln Asp 
    450                 455                 460                 


Gly Lys Met Glu Thr Gly Asp Val Ile Val Tyr Ile Asn Glu Val Cys 
465                 470                 475                 480 


Val Leu Gly His Thr His Ala Asp Val Val Lys Leu Phe Gln Ser Val 
                485                 490                 495     


Pro Ile Gly Gln Ser Val Asn Leu Val Leu Cys Arg Gly Tyr Pro Leu 
            500                 505                 510         


Pro Phe Asp Pro Glu Asp Pro Ala Asn Ser Met Val Pro Pro Leu Ala 
        515                 520                 525             


Ile Met Glu Arg Pro Pro Pro Val Met Val Asn Gly Arg His Asn Tyr 
    530                 535                 540                 


Glu Thr Tyr Leu Glu Tyr Ile Ser Arg Thr Ser Gln Ser Val Pro Asp 
545                 550                 555                 560 


Ile Thr Asp Arg Pro Pro His Ser Leu His Ser Met Pro Thr Asp Gly 
                565                 570                 575     


Gln Leu Asp Gly Thr Tyr Pro Pro Pro Val His Asp Asp Asn Val Ser 
            580                 585                 590         


Met Ala Ser Ser Gly Ala Thr Gln Ala Glu Leu Met Thr Leu Thr Ile 
        595                 600                 605             


Val Lys Gly Ala Gln Gly Phe Gly Phe Thr Ile Ala Asp Ser Pro Thr 
    610                 615                 620                 


Gly Gln Arg Val Lys Gln Ile Leu Asp Ile Gln Gly Cys Pro Gly Leu 
625                 630                 635                 640 


Cys Glu Gly Asp Leu Ile Val Glu Ile Asn Gln Gln Asn Val Gln Asn 
                645                 650                 655     


Leu Ser His Thr Glu Val Val Asp Ile Leu Lys Asp Cys Pro Ile Gly 
            660                 665                 670         


Ser Glu Thr Ser Leu Ile Ile His Arg Gly Gly Phe Phe Ser Pro Trp 
        675                 680                 685             


Lys Thr Pro Lys Pro Ile Met Asp Arg Trp Glu Asn Gln Gly Ser Pro 
    690                 695                 700                 


Gln Thr Ser Leu Ser Ala Pro Ala Ile Pro Gln Asn Leu Pro Phe Pro 
705                 710                 715                 720 


Pro Ala Leu His Arg Ser Ser Phe Pro Asp Ser Thr Glu Ala Phe Asp 
                725                 730                 735     


Pro Arg Lys Pro Asp Pro Tyr Glu Leu Tyr Glu Lys Ser Arg Ala Ile 
            740                 745                 750         


Tyr Glu Ser Arg Gln Gln Val Pro Pro Arg Thr Ser Phe Arg Met Asp 
        755                 760                 765             


Ser Ser Gly Pro Asp Tyr Lys Glu Leu Asp Val His Leu Arg Arg Met 
    770                 775                 780                 


Glu Ser Gly Phe Gly Phe Arg Ile Leu Gly Gly Asp Glu Pro Gly Gln 
785                 790                 795                 800 


Pro Ile Leu Ile Gly Ala Val Ile Ala Met Gly Ser Ala Asp Arg Asp 
                805                 810                 815     


Gly Arg Leu His Pro Gly Asp Glu Leu Val Tyr Val Asp Gly Ile Pro 
            820                 825                 830         


Val Ala Gly Lys Thr His Arg Tyr Val Ile Asp Leu Met His His Ala 
        835                 840                 845             


Ala Arg Asn Gly Gln Val Asn Leu Thr Val Arg Arg Lys Val Leu Cys 
    850                 855                 860                 


Gly Gly Glu Pro Cys Pro Glu Asn Gly Arg Ser Pro Gly Ser Val Ser 
865                 870                 875                 880 


Thr His His Ser Ser Pro Arg Ser Asp Tyr Ala Thr Tyr Thr Asn Ser 
                885                 890                 895     


Asn His Ala Ala Pro Ser Ser Asn Ala Ser Pro Pro Glu Gly Phe Ala 
            900                 905                 910         


Ser His Ser Leu Gln Thr Ser Asp Val Val Ile His Arg Lys Glu Asn 
        915                 920                 925             


Glu Gly Phe Gly Phe Val Ile Ile Ser Ser Leu Asn Arg Pro Glu Ser 
    930                 935                 940                 


Gly Ser Thr Ile Thr Val Pro His Lys Ile Gly Arg Ile Ile Asp Gly 
945                 950                 955                 960 


Ser Pro Ala Asp Arg Cys Ala Lys Leu Lys Val Gly Asp Arg Ile Leu 
                965                 970                 975     


Ala Val Asn Gly Gln Ser Ile Ile Asn Met Pro His Ala Asp Ile Val 
            980                 985                 990         


Lys Leu Ile Lys Asp Ala Gly Leu  Ser Val Thr Leu Arg  Ile Ile Pro 
        995                 1000                 1005             


Gln Glu  Glu Leu Asn Ser Pro  Thr Ser Ala Pro Ser  Ser Glu Lys 
    1010                 1015                 1020             


Gln Ser  Pro Met Ala Gln Gln  Ser Pro Leu Ala Gln  Gln Ser Pro 
    1025                 1030                 1035             


Leu Ala  Gln Pro Ser Pro Ala  Thr Pro Asn Ser Pro  Ile Ala Gln 
    1040                 1045                 1050             


Pro Ala  Pro Pro Gln Pro Leu  Gln Leu Gln Gly His  Glu Asn Ser 
    1055                 1060                 1065             


Tyr Arg  Ser Glu Val Lys Ala  Arg Gln Asp Val Lys  Pro Asp Ile 
    1070                 1075                 1080             


Arg Gln  Pro Pro Phe Thr Asp  Tyr Arg Gln Pro Pro  Leu Asp Tyr 
    1085                 1090                 1095             


Arg Gln  Pro Pro Gly Gly Asp  Tyr Gln Gln Pro Pro  Pro Leu Asp 
    1100                 1105                 1110             


Tyr Arg  Gln Pro Pro Leu Leu  Asp Tyr Arg Gln His  Ser Pro Asp 
    1115                 1120                 1125             


Thr Arg  Gln Tyr Pro Leu Ser  Asp Tyr Arg Gln Pro  Gln Asp Phe 
    1130                 1135                 1140             


Asp Tyr  Phe Thr Val Asp Met  Glu Lys Gly Ala Lys  Gly Phe Gly 
    1145                 1150                 1155             


Phe Ser  Ile Arg Gly Gly Arg  Glu Tyr Lys Met Asp  Leu Tyr Val 
    1160                 1165                 1170             


Leu Arg  Leu Ala Glu Asp Gly  Pro Ala Ile Arg Asn  Gly Arg Met 
    1175                 1180                 1185             


Arg Val  Gly Asp Gln Ile Ile  Glu Ile Asn Gly Glu  Ser Thr Arg 
    1190                 1195                 1200             


Asp Met  Thr His Ala Arg Ala  Ile Glu Leu Ile Lys  Ser Gly Gly 
    1205                 1210                 1215             


Arg Arg  Val Arg Leu Leu Leu  Lys Arg Gly Thr Gly  Gln Val Pro 
    1220                 1225                 1230             


Glu Tyr  Asp Glu Pro Ala Pro  Trp Ser Ser Pro Ala  Ala Ala Ala 
    1235                 1240                 1245             


Pro Gly  Leu Pro Glu Val Gly  Val Ser Leu Asp Asp  Gly Leu Ala 
    1250                 1255                 1260             


Pro Phe  Ser Pro Ser His Pro  Ala Pro Pro Ser Asp  Pro Ser His 
    1265                 1270                 1275             


Gln Ile  Ser Pro Gly Pro Thr  Trp Asp Ile Lys Arg  Glu His Asp 
    1280                 1285                 1290             


Val Arg  Lys Pro Lys Glu Leu  Ser Ala Cys Gly Gln  Lys Lys Gln 
    1295                 1300                 1305             


Arg Leu  Gly Glu Gln Arg Glu  Arg Ser Ala Ser Pro  Gln Arg Ala 
    1310                 1315                 1320             


Ala Arg  Pro Arg Leu Glu Glu  Ala Pro Gly Gly Gln  Gly Arg Pro 
    1325                 1330                 1335             


Glu Ala  Gly Arg Pro Ala Ser  Glu Ala Arg Ala Pro  Gly Leu Ala 
    1340                 1345                 1350             


Ala Ala  Asp Ala Ala Asp Ala  Ala Arg Ala Gly Gly  Lys Glu Ala 
    1355                 1360                 1365             


Pro Arg  Ala Ala Ala Gly Ser  Glu Leu Cys Arg Arg  Glu Gly Pro 
    1370                 1375                 1380             


Gly Ala  Ala Pro Ala Phe Ala  Gly Pro Gly Gly Gly  Gly Ser Gly 
    1385                 1390                 1395             


Ala Leu  Glu Ala Glu Gly Arg  Ala Gly Ala Arg Ala  Gly Pro Arg 
    1400                 1405                 1410             


Pro Gly  Pro Arg Pro Pro Gly  Gly Ala Pro Ala Arg  Lys Ala Ala 
    1415                 1420                 1425             


Val Ala  Pro Gly Pro Trp Lys  Val Pro Gly Ser Asp  Lys Leu Pro 
    1430                 1435                 1440             


Ser Val  Leu Lys Pro Gly Ala  Ser Ala Ala Ser Arg  
    1445                 1450                 1455 


<210>  795
<211>  1685
<212>  DNA
<213>  Homosapiens

<400>  795
atgccgacct tagatgctcc agaagagagg cggagaaaat ttaagtaccg aggcaaagat     60

gtgtctctga ggcgacagca gaggatggcg gtcagtctgg agctccgaaa ggccaagaaa    120

gatgaacaga ccttaaagag aaggaatatc acgagcttct gccctgacac accttctgaa    180

aaaacagcca aaggggtggc ggtcagcctc actctgggtg aaataatcaa aggtgtgaat    240

agctcagatc cagtcctatg tttccaggcc acccagacag ccaggaaaat gctatcccag    300

gaaaagaacc cccctctgaa actggtcatt gaagcgggcc tcattcccag gatggtggag    360

ttcctgaagt catcacttta cccctgcttg cagtttgagg ctgcctgggc cctgaccaac    420

atcgcttcag ggacttcgga gcagactcgt gccgtggtag aagggggagc catccagccc    480

ttgattgagc tcctgtcttc ctccaacgtg gctgtgtgtg aacaggcagt gtgggctctt    540

ggtaatatag ccggtgatgg cccagagttc agagataacg tcatcacaag caatgccatc    600

ccacatctcc tagccttgat ttcacccacc ctgccgatca catttctgcg gaacatcacg    660

tggaccttgt cgaatctgtg ccgaaacaag aacccatacc cttgcgacac tgcggtgaag    720

cagatactgc cggccctcct tcacctcctg cagcaccagg acagtgaggt tctctcggat    780

gcctgctggg cactgtccta cctcaccgac ggctccaaca agcgcatcgg ccaagtggtt    840

aacacggggg tcctgcccag gctggtagtg ctcatgacca gctcagaact caatgtcttg    900

actccttctc tccgcaccgt ggggaacatt gtcacgggca cagatgagca gacgcagatg    960

gccattgatg cgggtatgct gaacgtgctc ccccagctcc tgcaacacaa caagccctcc   1020

atccagaagg aggcagcctg ggccctgagc aacgtagcag cggggccttg tcaccacatc   1080

cagcagctgc ttgcctacga cgtcttgcct cccttggtgg ctctgctaaa aaacggagaa   1140

tttaaagtcc agaaagaggc tgtctggatg gtggcgaact ttgcaacagg ggccaccatg   1200

gatcagctga tccagctcgt ccactctggg gtcctggagc cactggtgaa tctgctcact   1260

gccccagatg ttaaaattgt tctcatcatc cttgatgtca tctcttgcat cctccaggcg   1320

gcagagaaac ggtctgagaa ggaaaacctg tgtcttctga tagaagaact tggtgggatc   1380

gatagaattg aggctttaca gctgcatgag aaccgtcaaa ttggccagtc ggctttgaac   1440

atcatcgaga agcactttgg tgaggaagaa gatgagagcc aaactttact gagccaagtc   1500

atagaccaag attatgaatt tatagattat gaatgcttag caaaaaaata gccaagctcc   1560

ctacctccta aaccaacaac ccagtgctaa aggataactt ctttaagaag cagcagtcct   1620

ctatcttagt gtaacccaaa tgtgaagctt ttaaaacttg acattaataa aatgttcaac   1680

acttt                                                               1685


<210>  796
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  796

Met Pro Thr Leu Asp Ala Pro Glu Glu Arg Arg Arg Lys Phe Lys Tyr 
1               5                   10                  15      


Arg Gly Lys Asp Val Ser Leu Arg Arg Gln Gln Arg Met Ala Val Ser 
            20                  25                  30          


Leu Glu Leu Arg Lys Ala Lys Lys Asp Glu Gln Thr Leu Lys Arg Arg 
        35                  40                  45              


Asn Ile Thr Ser Phe Cys Pro Asp Thr Pro Ser Glu Lys Thr Ala Lys 
    50                  55                  60                  


Gly Val Ala Val Ser Leu Thr Leu Gly Glu Ile Ile Lys Gly Val Asn 
65                  70                  75                  80  


Ser Ser Asp Pro Val Leu Cys Phe Gln Ala Thr Gln Thr Ala Arg Lys 
                85                  90                  95      


Met Leu Ser Gln Glu Lys Asn Pro Pro Leu Lys Leu Val Ile Glu Ala 
            100                 105                 110         


Gly Leu Ile Pro Arg Met Val Glu Phe Leu Lys Ser Ser Leu Tyr Pro 
        115                 120                 125             


Cys Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly 
    130                 135                 140                 


Thr Ser Glu Gln Thr Arg Ala Val Val Glu Gly Gly Ala Ile Gln Pro 
145                 150                 155                 160 


Leu Ile Glu Leu Leu Ser Ser Ser Asn Val Ala Val Cys Glu Gln Ala 
                165                 170                 175     


Val Trp Ala Leu Gly Asn Ile Ala Gly Asp Gly Pro Glu Phe Arg Asp 
            180                 185                 190         


Asn Val Ile Thr Ser Asn Ala Ile Pro His Leu Leu Ala Leu Ile Ser 
        195                 200                 205             


Pro Thr Leu Pro Ile Thr Phe Leu Arg Asn Ile Thr Trp Thr Leu Ser 
    210                 215                 220                 


Asn Leu Cys Arg Asn Lys Asn Pro Tyr Pro Cys Asp Thr Ala Val Lys 
225                 230                 235                 240 


Gln Ile Leu Pro Ala Leu Leu His Leu Leu Gln His Gln Asp Ser Glu 
                245                 250                 255     


Val Leu Ser Asp Ala Cys Trp Ala Leu Ser Tyr Leu Thr Asp Gly Ser 
            260                 265                 270         


Asn Lys Arg Ile Gly Gln Val Val Asn Thr Gly Val Leu Pro Arg Leu 
        275                 280                 285             


Val Val Leu Met Thr Ser Ser Glu Leu Asn Val Leu Thr Pro Ser Leu 
    290                 295                 300                 


Arg Thr Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln Met 
305                 310                 315                 320 


Ala Ile Asp Ala Gly Met Leu Asn Val Leu Pro Gln Leu Leu Gln His 
                325                 330                 335     


Asn Lys Pro Ser Ile Gln Lys Glu Ala Ala Trp Ala Leu Ser Asn Val 
            340                 345                 350         


Ala Ala Gly Pro Cys His His Ile Gln Gln Leu Leu Ala Tyr Asp Val 
        355                 360                 365             


Leu Pro Pro Leu Val Ala Leu Leu Lys Asn Gly Glu Phe Lys Val Gln 
    370                 375                 380                 


Lys Glu Ala Val Trp Met Val Ala Asn Phe Ala Thr Gly Ala Thr Met 
385                 390                 395                 400 


Asp Gln Leu Ile Gln Leu Val His Ser Gly Val Leu Glu Pro Leu Val 
                405                 410                 415     


Asn Leu Leu Thr Ala Pro Asp Val Lys Ile Val Leu Ile Ile Leu Asp 
            420                 425                 430         


Val Ile Ser Cys Ile Leu Gln Ala Ala Glu Lys Arg Ser Glu Lys Glu 
        435                 440                 445             


Asn Leu Cys Leu Leu Ile Glu Glu Leu Gly Gly Ile Asp Arg Ile Glu 
    450                 455                 460                 


Ala Leu Gln Leu His Glu Asn Arg Gln Ile Gly Gln Ser Ala Leu Asn 
465                 470                 475                 480 


Ile Ile Glu Lys His Phe Gly Glu Glu Glu Asp Glu Ser Gln Thr Leu 
                485                 490                 495     


Leu Ser Gln Val Ile Asp Gln Asp Tyr Glu Phe Ile Asp Tyr Glu Cys 
            500                 505                 510         


Leu Ala Lys Lys 
        515     


<210>  797
<211>  1619
<212>  DNA
<213>  Homosapiens

<400>  797
tcagccgctc cctctgggct tccgtcctcc gcccgcgccc gacggagcct gttcgcgtcg     60

actgcccaga gtccgcgaat cctccgctcc gagcccgtcc ggactccccc gatcccagct    120

ttctctcctt tgaaaacact aagaataatg tcactgcatc agtttttact agagccaatc    180

acctgtcatg cctggaacag ggatcgtact cagattgccc tcagtcccaa taatcacgaa    240

gtgcacatct ataagaagaa cgggagccag tgggtgaaag ctcatgaact caaggagcac    300

aacggacaca tcacaggtat tgactgggct cccaagagcg accgcattgt cacttgtggg    360

gcagaccgca atgcctatgt ctggagtcag aaagatggtg tttggaagcc aaccctggtg    420

atcctgagaa ttaatcgcgc agctactttt gtgaagtggt cccccctaga gaacaaattt    480

gctgtgggaa gtggagcacg actcatttct gtttgttact ttgagtctga aaatgactgg    540

tgggtgagca agcacattaa aaagccgatt cgctccacag tcctcagctt ggattggcat    600

cccaacaacg ttttgctggc agcaggatca tgtgacttca aatgcagagt gttttctgcc    660

tacattaaag aagtggatga aaagccagcc agcacgccct ggggcagcaa gatgcctttt    720

gggcagctga tgtcagagtt tggtggcagt ggcactggtg gctgggtcca cggggtaagc    780

ttctctgcca gtgggagccg cctggcctgg gtcagccacg acagcaccgt gtctgttgct    840

gatgcctcaa aaagtgtgca ggtctcgact ctgaagacag agttcctgcc gctcctaagt    900

gtgtcatttg tctcagagaa cagcgtcgtg gctgctggcc atgactgctg cccaatgctc    960

tttaactacg atgaccgcgg ctgcctgacc ttcgtctcca agttagatat tccaaaacag   1020

agcatccaac gcaacatgtc tgccatggaa cgcttccgca acatggacaa gagagccaca   1080

actgaggacc gcaacacggc cttggagacg ctgcaccaga atagcatcac tcaagtctct   1140

atttatgagg tggacaagca agattgtcgc aaattttgca ctactggcat cgatggagcc   1200

atgacaattt gggatttcaa gaccctcgag tcttccatcc agggcctccg gataatgtga   1260

agctgagtga gcctccgcca tccagcatga caaactgtgg ccgaccgcag ctgtgccgtg   1320

gcacgatggc gaggaagcca gccccaagga aacactgaaa acacatatca cgccaatgcc   1380

gtgtggtttt gtttgaatat aaaattggtg aaagtgttgg tttttttaag gcagtaattt   1440

ttttgtttgt ttttttgcga tttcattcca ttcttgacca aagcttctct ttaagtagtt   1500

tattatggaa aattgtcaca ctaacttaaa agacagggtg agggagatat gtaaattgtc   1560

cactagaaaa ttaaataaaa gaactgaatg tggaaaaaaa aaaaaaaaaa aaaaaaaaa    1619


<210>  798
<211>  370
<212>  PRT
<213>  Homosapiens

<400>  798

Met Ser Leu His Gln Phe Leu Leu Glu Pro Ile Thr Cys His Ala Trp 
1               5                   10                  15      


Asn Arg Asp Arg Thr Gln Ile Ala Leu Ser Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly His Ile Thr Gly Ile Asp Trp Ala Pro Lys Ser 
    50                  55                  60                  


Asp Arg Ile Val Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val Trp Ser 
65                  70                  75                  80  


Gln Lys Asp Gly Val Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Thr Phe Val Lys Trp Ser Pro Leu Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu Ser Glu 
        115                 120                 125             


Asn Asp Trp Trp Val Ser Lys His Ile Lys Lys Pro Ile Arg Ser Thr 
    130                 135                 140                 


Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 
145                 150                 155                 160 


Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys Glu Val 
                165                 170                 175     


Asp Glu Lys Pro Ala Ser Thr Pro Trp Gly Ser Lys Met Pro Phe Gly 
            180                 185                 190         


Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Thr Gly Gly Trp Val His 
        195                 200                 205             


Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val Ser His 
    210                 215                 220                 


Asp Ser Thr Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln Val Ser 
225                 230                 235                 240 


Thr Leu Lys Thr Glu Phe Leu Pro Leu Leu Ser Val Ser Phe Val Ser 
                245                 250                 255     


Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys Pro Met Leu Phe 
            260                 265                 270         


Asn Tyr Asp Asp Arg Gly Cys Leu Thr Phe Val Ser Lys Leu Asp Ile 
        275                 280                 285             


Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met Glu Arg Phe Arg 
    290                 295                 300                 


Asn Met Asp Lys Arg Ala Thr Thr Glu Asp Arg Asn Thr Ala Leu Glu 
305                 310                 315                 320 


Thr Leu His Gln Asn Ser Ile Thr Gln Val Ser Ile Tyr Glu Val Asp 
                325                 330                 335     


Lys Gln Asp Cys Arg Lys Phe Cys Thr Thr Gly Ile Asp Gly Ala Met 
            340                 345                 350         


Thr Ile Trp Asp Phe Lys Thr Leu Glu Ser Ser Ile Gln Gly Leu Arg 
        355                 360                 365             


Ile Met 
    370 


<210>  799
<211>  1520
<212>  DNA
<213>  Homosapiens

<400>  799
ggctgctgct ccggcgcgga gcccagagcc ggttcggcgc gtcgactgcc cagagtccgc     60

ggccggggcg cgggaggagc caagccgcca tggcctacca cagcttcctg gtggagccca    120

tcagctgcca cgcctggaac aaggaccgca cccagattgc catctgcccc aacaaccatg    180

aggtgcatat ctatgaaaag agcggtgcca aatggaccaa ggtgcacgag ctcaaggagc    240

acaacgggca ggtgacaggc atcgactggg cccccgagag taaccgtatt gtgacctgcg    300

gcacagaccg caacgcctac gtgtggacgc tgaagggccg cacatggaag cccacgctgg    360

tcatcctgcg gatcaaccgg gctgcccgct gcgtgcgctg ggcccccaac gagaacaagt    420

ttgctgtggg cagcggctct cgtgtgatct ccatctgtta tttcgagcag gagaatgact    480

ggtgggtttg caagcacatc aagaagccca tccgctccac cgtcctcagc ctggactggc    540

accccaacaa tgtgctgctg gctgccggct cctgtgactt caagtgtcgg atcttttcag    600

cctacatcaa ggaggtggag gaacggccgg cacccacccc gtggggctcc aagatgccct    660

ttggggaact gatgttcgaa tccagcagta gctgcggctg ggtacatggc gtctgtttct    720

cagccagcgg gagccgcgtg gcctgggtaa gccacgacag caccgtctgc ctggctgatg    780

ccgacaagaa gatggccgtc gcgactctgg cctctgaaac actaccactg ctggcgctga    840

ccttcatcac agacaacagc ctggtggcag cgggccacga ctgcttcccg gtgctgttca    900

cctatgacgc cgccgcgggg atgctgagct tcggcgggcg gctggacgtt cctaagcaga    960

gctcgcagcg tggcttgacg gcccgcgagc gcttccagaa cctggacaag aaggcgagct   1020

ccgagggtgg cacggctgcg ggcgcgggcc tagactcgct gcacaagaac agcgtcagcc   1080

agatctcggt gctcagcggc ggcaaggcca agtgctcgca gttctgcacc actggcatgg   1140

atggcggcat gagtatctgg gatgtgaaga gcttggagtc agccttgaag gacctcaaga   1200

tcaaatgacc tgtgaggaat atgttgcctt catcctagct gctggggaag cggggagagg   1260

ggtcagggag gctaatggtt gctttgctga atgtttctgg ggtaccaata cgagttccca   1320

taggggctgc tccctcaaaa agggagggga cagatgggga gcttttctta cctattcaag   1380

gaatacgtgc ctttttctta aatgctttca tttattgaaa aaaaaaaaaa atgcccccaa   1440

agcactatgc tggtcatgaa ctgcttcaaa atgtggaggt aataaaatgc aactgtgtaa   1500

aaaaaaaaaa aaaaaaaaaa                                               1520


<210>  800
<211>  372
<212>  PRT
<213>  Homosapiens

<400>  800

Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Thr Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Thr Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Thr Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Thr Cys Gly Thr Asp Arg Asn Ala Tyr Val Trp Thr 
65                  70                  75                  80  


Leu Lys Gly Arg Thr Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ser Arg Val Ile Ser Ile Cys Tyr Phe Glu Gln Glu 
        115                 120                 125             


Asn Asp Trp Trp Val Cys Lys His Ile Lys Lys Pro Ile Arg Ser Thr 
    130                 135                 140                 


Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 
145                 150                 155                 160 


Ser Cys Asp Phe Lys Cys Arg Ile Phe Ser Ala Tyr Ile Lys Glu Val 
                165                 170                 175     


Glu Glu Arg Pro Ala Pro Thr Pro Trp Gly Ser Lys Met Pro Phe Gly 
            180                 185                 190         


Glu Leu Met Phe Glu Ser Ser Ser Ser Cys Gly Trp Val His Gly Val 
        195                 200                 205             


Cys Phe Ser Ala Ser Gly Ser Arg Val Ala Trp Val Ser His Asp Ser 
    210                 215                 220                 


Thr Val Cys Leu Ala Asp Ala Asp Lys Lys Met Ala Val Ala Thr Leu 
225                 230                 235                 240 


Ala Ser Glu Thr Leu Pro Leu Leu Ala Leu Thr Phe Ile Thr Asp Asn 
                245                 250                 255     


Ser Leu Val Ala Ala Gly His Asp Cys Phe Pro Val Leu Phe Thr Tyr 
            260                 265                 270         


Asp Ala Ala Ala Gly Met Leu Ser Phe Gly Gly Arg Leu Asp Val Pro 
        275                 280                 285             


Lys Gln Ser Ser Gln Arg Gly Leu Thr Ala Arg Glu Arg Phe Gln Asn 
    290                 295                 300                 


Leu Asp Lys Lys Ala Ser Ser Glu Gly Gly Thr Ala Ala Gly Ala Gly 
305                 310                 315                 320 


Leu Asp Ser Leu His Lys Asn Ser Val Ser Gln Ile Ser Val Leu Ser 
                325                 330                 335     


Gly Gly Lys Ala Lys Cys Ser Gln Phe Cys Thr Thr Gly Met Asp Gly 
            340                 345                 350         


Gly Met Ser Ile Trp Asp Val Lys Ser Leu Glu Ser Ala Leu Lys Asp 
        355                 360                 365             


Leu Lys Ile Lys 
    370         


<210>  801
<211>  2383
<212>  DNA
<213>  Homosapiens

<400>  801
actgcggcca ctgaagcggc ggcggcggct ggcccaggag gaagaagtcg agcccaagct     60

atttccggtt ccggtgtcag ttcgaggcgc cgccgccgcc gccgcagccg ccggagccgc    120

aatgcctaaa ggaggaagaa agggaggcca caaaggccgg gcgaggcagt atacaagccc    180

tgaggagatc gacgcgcagc tgcaggctga gaagcagaag gccagggaag aagaggagca    240

aaaagaaggt ggagatgggg ctgcaggtga ccccaaaaag gagaagaaat ctctagactc    300

agatgagagt gaggatgaag aagatgacta ccagcaaaag cgcaaaggcg ttgaagggct    360

catcgacatc gagaacccca accgggtggc acagacaacc aaaaaggtca cacaactgga    420

tctggacggg ccaaaggagc tttcgaggag agaacgagaa gagattgaga agcagaaggc    480

aaaagagcgt tacatgaaaa tgcacttggc cgggaagaca gagcaagcca aggctgacct    540

ggcccggctg gccatcatcc ggaaacagcg ggaggaggct gcccggaaga aggaagagga    600

aaggaaagca aaagacgatg ccacattgtc aggaaaacga atgcagtcac tctccctgaa    660

taagtaactg cgacccgtgg gaggagatgc cggggacctg ggccgcgctg ccaggacctc    720

tgctgtgtct cgcccaccct gtgccctggc gccgctgcaa cagcccctca tggccaggag    780

ccccccatgg cctggggcct cctcttcatc ttggcacaga aattgtttgg gggatggggg    840

gggggactgg gggaggggta gctgctatct ttgagacaga aagatgcagg acagcatttc    900

atatgtaacc atttgaatgt ttttgctgtt tttagaattc agagcccttg ctggggggtg    960

cctgggagat ggggtaagaa gagctttcat ttgtctggta gatagatagc atgtaagggg   1020

gtggttgtcc caggaggcag ctgctgacag gtttgctaca cacagccccg gactgtgttg   1080

cctgggtgct cattcagaga ggggctatca tctgggagcc tgtgcccctg ggtcctcgag   1140

ggtcatggct tgtccctggt cagtcctgtc tgactgacct cagggcctca cctctctgcc   1200

cttccctgcc cggttcctac tcacctggct agggccagtg cccattttca gccctaccca   1260

ttgatcattt caagaaacct ctgtttactg tgtggcaccc aggcaaaaca tgctccacaa   1320

attcaacttg tatatttggc agattaaact tgacattatc gtaatctttg ttttggcaat   1380

ccatcctttg gcttccgtgc tcgagccgtt tttacccagc tgggtacggt gccacgttca   1440

ggcacgtgca cccggcaagg ttcagggcac atacctacct ggggcatgac atctgtcagg   1500

tggcaccgag caggatgcgg ggatggaccc tagataccac agcctgcccc ctcccctcct   1560

ttagccaagt caggatctta ggcctcagca ggcagggacc cttccaggcc acagtaggct   1620

gaagcagcac caggatcctg gcctggcctg gcctgtaggt gtcccctggt ggttataatt   1680

ctgtaactct aggggagaag gggaatagca ctagcattgg atgtcgccaa ggcccacatt   1740

ttcctgagag aagccacaaa agatgtgcaa atgcccttca gcacaggacc tggtgacatg   1800

acataaactc caagacagaa cctcagttta cagcacacga aaaaaatatc ttgccaacat   1860

tgtaatgaca aaataaattc ccgtgaagtt ccacaaccag gccgggcatg gtggctcatg   1920

cctgtaatcc cagcactttg ggaggtgagg tgggtggatc atctgaggtc aggagttcaa   1980

gaccagcctg gccaacatgg agaaactccg tctctactaa aaatacaaaa attaaccagg   2040

cttggtggtg tatgcctgta atcccagcta cttgggaggc tgaggcagga gaatcgcttg   2100

atcccaggaa ggcagaggtg gcagtgagct gagaacgcac aactgcactc cagcctgggt   2160

gacgagcaaa actccatctc aaaacaaaag ttccacaacc agcctggagt gtgtagcccc   2220

tttgtccagg aatttgacta gtcaatcagt gacacctggt actggcagtt ttgggagtgg   2280

cagcccagga tggacagcag tggggaggga accatttggc ataaggccgt tgggcttcag   2340

gatcaatttt gttggcaagc agtaaaaata agctatctac cta                     2383


<210>  802
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  802

Met Pro Lys Gly Gly Arg Lys Gly Gly His Lys Gly Arg Ala Arg Gln 
1               5                   10                  15      


Tyr Thr Ser Pro Glu Glu Ile Asp Ala Gln Leu Gln Ala Glu Lys Gln 
            20                  25                  30          


Lys Ala Arg Glu Glu Glu Glu Gln Lys Glu Gly Gly Asp Gly Ala Ala 
        35                  40                  45              


Gly Asp Pro Lys Lys Glu Lys Lys Ser Leu Asp Ser Asp Glu Ser Glu 
    50                  55                  60                  


Asp Glu Glu Asp Asp Tyr Gln Gln Lys Arg Lys Gly Val Glu Gly Leu 
65                  70                  75                  80  


Ile Asp Ile Glu Asn Pro Asn Arg Val Ala Gln Thr Thr Lys Lys Val 
                85                  90                  95      


Thr Gln Leu Asp Leu Asp Gly Pro Lys Glu Leu Ser Arg Arg Glu Arg 
            100                 105                 110         


Glu Glu Ile Glu Lys Gln Lys Ala Lys Glu Arg Tyr Met Lys Met His 
        115                 120                 125             


Leu Ala Gly Lys Thr Glu Gln Ala Lys Ala Asp Leu Ala Arg Leu Ala 
    130                 135                 140                 


Ile Ile Arg Lys Gln Arg Glu Glu Ala Ala Arg Lys Lys Glu Glu Glu 
145                 150                 155                 160 


Arg Lys Ala Lys Asp Asp Ala Thr Leu Ser Gly Lys Arg Met Gln Ser 
                165                 170                 175     


Leu Ser Leu Asn Lys 
            180     


<210>  803
<211>  1049
<212>  DNA
<213>  Homosapiens

<400>  803
gctccaggag cttccggtat gtgttttccc tctgttctcg attaccttgg caacggctga     60

ggcgggagac cggtggtctg caccgtcctg gagggagata tgagtggctg gactctcagc    120

cagccactgg gatgtgttcg ggctttggac cctgaggccg gagagagctc ccgagaggag    180

gcggcgccac gttcgttctt ctgaggggac ggtagatttg ggggttttcc tctaggattc    240

tcgcgccgtt tcctctgaag aaacaggacc agagagggaa ggtgacctga aagtcacaga    300

ataatttttt agagctgaac aagaatccaa gcctgcaact gcagagacga gagatctttc    360

tgctgtctat actcttggaa agcacatcct aagatctttg cagattatcc tgtggaagga    420

aaatgcctaa agtcaaaaga agccggaaag cacccccaga tggctgggag ttgattgagc    480

caacactgga tgaattagat caaaagatga gagaagctga aacagaaccg catgagggaa    540

agaggaaagt ggaatctctg tggcccatct tcaggatcca ccaccagaaa acccgctaca    600

tcttcgacct cttttacaag cggaaagcca tcagcagaga actctatgaa tattgtatta    660

aagaaggcta tgcagacaaa aacctgattg caaaatggaa aaagcaagga tatgagaact    720

tgtgctgcct gcggtgcatt cagacacggg acaccaactt cgggacgaac tgcatctgcc    780

gcgtgcccaa aagcaagctg gaagtgggcc gcatcatcga gtgcacacac tgtggctgtc    840

gtggctgctc tggctgaggc tggcgcgctc caccctggac tctggacttc gcaggttcct    900

gcctgtcacg ccaccccctt cctgggagca gcgagcagtg ccccaggccc gagttggagc    960

acggtctcta tggggaaggc ttcgctgtct atcagctgtg atttgtaaaa ataaaatctt   1020

taaatctctc gaaaaaaaaa aaaaaaaaa                                     1049


<210>  804
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  804

Met Pro Lys Val Lys Arg Ser Arg Lys Ala Pro Pro Asp Gly Trp Glu 
1               5                   10                  15      


Leu Ile Glu Pro Thr Leu Asp Glu Leu Asp Gln Lys Met Arg Glu Ala 
            20                  25                  30          


Glu Thr Glu Pro His Glu Gly Lys Arg Lys Val Glu Ser Leu Trp Pro 
        35                  40                  45              


Ile Phe Arg Ile His His Gln Lys Thr Arg Tyr Ile Phe Asp Leu Phe 
    50                  55                  60                  


Tyr Lys Arg Lys Ala Ile Ser Arg Glu Leu Tyr Glu Tyr Cys Ile Lys 
65                  70                  75                  80  


Glu Gly Tyr Ala Asp Lys Asn Leu Ile Ala Lys Trp Lys Lys Gln Gly 
                85                  90                  95      


Tyr Glu Asn Leu Cys Cys Leu Arg Cys Ile Gln Thr Arg Asp Thr Asn 
            100                 105                 110         


Phe Gly Thr Asn Cys Ile Cys Arg Val Pro Lys Ser Lys Leu Glu Val 
        115                 120                 125             


Gly Arg Ile Ile Glu Cys Thr His Cys Gly Cys Arg Gly Cys Ser Gly 
    130                 135                 140                 


<210>  805
<211>  3079
<212>  DNA
<213>  Homosapiens

<400>  805
attgcgcctg cgcgcttggg gagaggggga cccgaggaag agactggttc gccgcgggga     60

ccgggcaggg ctccccgtcg gagtgcactg cgccggacac ttcaagccct ggagggacag    120

gaaagccaga aatggacttc gtgagactcg ctcgactgtt cgccagggcc cgccccatgg    180

gactgttcat cctgcaacac ctggacccct gtagagccag gtgggcagga ggcagggagg    240

ggctgatgcg gccaatgtgg gcgcccttca gcagctcctc ctctcagctg cccctcggcc    300

aggagcgtca ggaaaacacg ggcagcctgg gctctgaccc gagccactcc aactccacgg    360

ccacgcagga agaagacgag gaggaggagg agagttttgg gaccctctct gacaaatact    420

cctcccggag actattccgc aaatccgcag cccagttcca taacctgcgg tttggggaac    480

ggagagatga gcaaatggaa ccggagccca aattatggcg aggccggaga aacaccccgt    540

actggtactt cttgcagtgc aaacacctga tcaaggaagg gaagctggtt gaagccctgg    600

acctgtttga gaggcagatg ctgaaggagg agcgattgca gcccatggag agcaactaca    660

cggtgctgat tgggggctgc gggcgggttg gctacctgaa gaaggccttc aacctctaca    720

accagatgaa aaagcgggac ctggagccct cggacgccac ctacacggcc ctgttcaacg    780

tctgtgccga gtccccctgg aaggactcag ctctacagag cgccctgaag ctccggcagc    840

agctgcaggc caaaaacttc gagctcaact tgaaaacata ccacgcgctg ctgaagatgg    900

ctgccaagtg cgcagacctt aggatgtgcc tcgatgtgtt caaggaaatc atccacaaag    960

ggcacgtggt cacagaggag accttcagtt tcctgctcat gggctgcatc caagacaaga   1020

agacaggctt ccggtacgcc ctccaggtgt ggcggctgat gctgagtcta gggctacagc   1080

cgagccggga cagctacaac ctgctgttgg tggcagctcg ggactgtggc ctaggggacc   1140

cccaggtggc ctcagagctg cttctgaagc ccagggagga ggcgactgtg cttcagcccc   1200

cagtgagcag gcagcggcca aggaggacag cccaggccaa ggcaggcaac ctcatgtcag   1260

ccatgctgca tgtggaggcc ctggagaggc agctgtttct ggaaccttct caggcacttg   1320

ggcctccaga gcctccggaa gccagagtgc ccggcaaggc ccaaccagag gtggatacta   1380

aggcagagcc cagccacaca gcagccctca ccgcagtggc cctgaagcca cctcccgtgg   1440

agctggaagt caacctcctg acccccgggg ccgttccccc tacagtggtc tcctttggaa   1500

cggtgaccac cccagctgac cggctggcct tgataggggg cctggagggc ttcctgagca   1560

agatggcaga gcacaggcag cagcccgaca tcaggaccct cacgctactg gccgaggtgg   1620

tggagtccgg gagtcctgca gagtccttgc tgctggccct cctggatgag caccaggtag   1680

aggccgacct gacattcttt aacacgctgg tgagaaagaa gagcaagctg ggagacctgg   1740

agggggccaa ggcgctgttg ccggtcctgg caaagagggg cctcgtcccc aacctgcaga   1800

cattctgcaa cctggccatc gggtgccaca ggccgaagga cggtctacag cttctcacag   1860

acatgaagaa gtcccaggtg acccccaaca ctcacatcta cagtgccctc atcaacgcgg   1920

ccatcaggaa gctgaactac acctatctca tcagcatctt gaaggacatg aagcagaaca   1980

gggtcccggt gaacgaagtg gtcatccgcc agctggagtt tgcagcccag taccctccca   2040

cctttgaccg gtaccaaggg aagaacacct acctggagaa gattgacggc ttccgagcct   2100

attacaagca gtggctgaca gtgatgcccg cagaggaaac cccgcacccc tggcagaagt   2160

tccggaccaa gccccagggg gaccaggaca ccggcaagga ggctgatgac ggatgtgccc   2220

ttgggggcag gtgatgggag cacagctgga acaatgtgct cggcccccag tgctctgtgg   2280

gagccccagg acaagtgagc tggtgtcacc tcctgcctgg gggaagagcc aggccctgag   2340

gaacagccgc agcgtgtcac aggtgttggt gaggacacac actaggccca aggtgcctgt   2400

gctcccagca ggtccaagtg cagctccagc cacctttgcg tgtcaccttc acgggacttc   2460

cagctccagc tacctttgtg tgtcacctca cacaccacaa gggggctggg gcatctggtc   2520

cctggggcct gggccgcccc gccgggttcc ataggccgat gctctgaaag aagagacgtg   2580

gggctcgaga gatttaaaga ttttattttt acaaatcaca gctgatagac agcgaagcct   2640

tccccataga gaccgtgctc caactcgggc ctggggcact gctcgctgct cccaggaagg   2700

gggtggcgtg acaggcagga acctgcgaag tccagagtcc agggtggagc gcgccagcct   2760

cagccagagc agccacgaca gccacagtgt gtgcactcga tgatgcggcc ctgcaacgga   2820

ggaggacagt gagacgatgc cactgcgcca cgctcgcccc tgcacactca catatgtggc   2880

aaccctccca cgaaggacct gccaccatgc catataggga cacacctcag aaacccttcc   2940

ttgacagctc tggacaggga aaatttggct ccctcatgaa ggtagaacca gctgctgttg   3000

acaccgaggt tacatctgta tgtctattta taatatgttc tgcaaatcca acacacgttt   3060

gccaatcaag aaaaagaaa                                                3079


<210>  806
<211>  700
<212>  PRT
<213>  Homosapiens

<400>  806

Met Asp Phe Val Arg Leu Ala Arg Leu Phe Ala Arg Ala Arg Pro Met 
1               5                   10                  15      


Gly Leu Phe Ile Leu Gln His Leu Asp Pro Cys Arg Ala Arg Trp Ala 
            20                  25                  30          


Gly Gly Arg Glu Gly Leu Met Arg Pro Met Trp Ala Pro Phe Ser Ser 
        35                  40                  45              


Ser Ser Ser Gln Leu Pro Leu Gly Gln Glu Arg Gln Glu Asn Thr Gly 
    50                  55                  60                  


Ser Leu Gly Ser Asp Pro Ser His Ser Asn Ser Thr Ala Thr Gln Glu 
65                  70                  75                  80  


Glu Asp Glu Glu Glu Glu Glu Ser Phe Gly Thr Leu Ser Asp Lys Tyr 
                85                  90                  95      


Ser Ser Arg Arg Leu Phe Arg Lys Ser Ala Ala Gln Phe His Asn Leu 
            100                 105                 110         


Arg Phe Gly Glu Arg Arg Asp Glu Gln Met Glu Pro Glu Pro Lys Leu 
        115                 120                 125             


Trp Arg Gly Arg Arg Asn Thr Pro Tyr Trp Tyr Phe Leu Gln Cys Lys 
    130                 135                 140                 


His Leu Ile Lys Glu Gly Lys Leu Val Glu Ala Leu Asp Leu Phe Glu 
145                 150                 155                 160 


Arg Gln Met Leu Lys Glu Glu Arg Leu Gln Pro Met Glu Ser Asn Tyr 
                165                 170                 175     


Thr Val Leu Ile Gly Gly Cys Gly Arg Val Gly Tyr Leu Lys Lys Ala 
            180                 185                 190         


Phe Asn Leu Tyr Asn Gln Met Lys Lys Arg Asp Leu Glu Pro Ser Asp 
        195                 200                 205             


Ala Thr Tyr Thr Ala Leu Phe Asn Val Cys Ala Glu Ser Pro Trp Lys 
    210                 215                 220                 


Asp Ser Ala Leu Gln Ser Ala Leu Lys Leu Arg Gln Gln Leu Gln Ala 
225                 230                 235                 240 


Lys Asn Phe Glu Leu Asn Leu Lys Thr Tyr His Ala Leu Leu Lys Met 
                245                 250                 255     


Ala Ala Lys Cys Ala Asp Leu Arg Met Cys Leu Asp Val Phe Lys Glu 
            260                 265                 270         


Ile Ile His Lys Gly His Val Val Thr Glu Glu Thr Phe Ser Phe Leu 
        275                 280                 285             


Leu Met Gly Cys Ile Gln Asp Lys Lys Thr Gly Phe Arg Tyr Ala Leu 
    290                 295                 300                 


Gln Val Trp Arg Leu Met Leu Ser Leu Gly Leu Gln Pro Ser Arg Asp 
305                 310                 315                 320 


Ser Tyr Asn Leu Leu Leu Val Ala Ala Arg Asp Cys Gly Leu Gly Asp 
                325                 330                 335     


Pro Gln Val Ala Ser Glu Leu Leu Leu Lys Pro Arg Glu Glu Ala Thr 
            340                 345                 350         


Val Leu Gln Pro Pro Val Ser Arg Gln Arg Pro Arg Arg Thr Ala Gln 
        355                 360                 365             


Ala Lys Ala Gly Asn Leu Met Ser Ala Met Leu His Val Glu Ala Leu 
    370                 375                 380                 


Glu Arg Gln Leu Phe Leu Glu Pro Ser Gln Ala Leu Gly Pro Pro Glu 
385                 390                 395                 400 


Pro Pro Glu Ala Arg Val Pro Gly Lys Ala Gln Pro Glu Val Asp Thr 
                405                 410                 415     


Lys Ala Glu Pro Ser His Thr Ala Ala Leu Thr Ala Val Ala Leu Lys 
            420                 425                 430         


Pro Pro Pro Val Glu Leu Glu Val Asn Leu Leu Thr Pro Gly Ala Val 
        435                 440                 445             


Pro Pro Thr Val Val Ser Phe Gly Thr Val Thr Thr Pro Ala Asp Arg 
    450                 455                 460                 


Leu Ala Leu Ile Gly Gly Leu Glu Gly Phe Leu Ser Lys Met Ala Glu 
465                 470                 475                 480 


His Arg Gln Gln Pro Asp Ile Arg Thr Leu Thr Leu Leu Ala Glu Val 
                485                 490                 495     


Val Glu Ser Gly Ser Pro Ala Glu Ser Leu Leu Leu Ala Leu Leu Asp 
            500                 505                 510         


Glu His Gln Val Glu Ala Asp Leu Thr Phe Phe Asn Thr Leu Val Arg 
        515                 520                 525             


Lys Lys Ser Lys Leu Gly Asp Leu Glu Gly Ala Lys Ala Leu Leu Pro 
    530                 535                 540                 


Val Leu Ala Lys Arg Gly Leu Val Pro Asn Leu Gln Thr Phe Cys Asn 
545                 550                 555                 560 


Leu Ala Ile Gly Cys His Arg Pro Lys Asp Gly Leu Gln Leu Leu Thr 
                565                 570                 575     


Asp Met Lys Lys Ser Gln Val Thr Pro Asn Thr His Ile Tyr Ser Ala 
            580                 585                 590         


Leu Ile Asn Ala Ala Ile Arg Lys Leu Asn Tyr Thr Tyr Leu Ile Ser 
        595                 600                 605             


Ile Leu Lys Asp Met Lys Gln Asn Arg Val Pro Val Asn Glu Val Val 
    610                 615                 620                 


Ile Arg Gln Leu Glu Phe Ala Ala Gln Tyr Pro Pro Thr Phe Asp Arg 
625                 630                 635                 640 


Tyr Gln Gly Lys Asn Thr Tyr Leu Glu Lys Ile Asp Gly Phe Arg Ala 
                645                 650                 655     


Tyr Tyr Lys Gln Trp Leu Thr Val Met Pro Ala Glu Glu Thr Pro His 
            660                 665                 670         


Pro Trp Gln Lys Phe Arg Thr Lys Pro Gln Gly Asp Gln Asp Thr Gly 
        675                 680                 685             


Lys Glu Ala Asp Asp Gly Cys Ala Leu Gly Gly Arg 
    690                 695                 700 


<210>  807
<211>  1717
<212>  DNA
<213>  Homosapiens

<400>  807
tcgctcgctc ctccttcgct tcgcctcgcc gccgccatgc aggaaatcat cgccagcgtg     60

gaccacatca agtttgactt ggagatcgcg gtggagcagc agctgggggc gcagccgctg    120

cccttccccg gcatggacaa gtcgggcgct gctgtctgtg aattcttttt gaaagctgcc    180

tgcggcaaag ggggcatgtg tccgtttcgc cacatcagtg gtgagaagac agttgtgtgc    240

aaacactggc tgcgtggcct atgcaagaaa ggggaccagt gtgagttcct gcatgagtat    300

gacatgacca agatgcccga gtgctacttc tactccaagt tcggggagtg cagcaacaag    360

gaatgtccct tcctgcacat cgaccccgag tccaagatca aggactgtcc ttggtatgac    420

cgcggcttct gcaagcacgg tcccctctgc aggcaccggc acacacggag agtcatctgt    480

gtgaattacc tcgtgggatt ctgcccggag gggccctcgt gtaaattcat gcaccctcga    540

tttgaactgc ccatgggaac caccgagcag cccccactgc cacagcagac acagcctcca    600

gcaaagcaaa gtaacaatcc gccattacaa aggtcgtcct ccttgatcca gttaacgagt    660

cagaactctt ctcccaatca gcagagaacc ccgcaggtca tcggggtcat gcagagtcaa    720

aacagcagcg cgggcaaccg gggaccccgg ccactggagc aggtcacctg ttacaagtgt    780

ggcgagaaag gacactacgc caacagatgc accaaagggc acttggcctt tctcagtgga    840

cagtgacagc agctggagcc agctccgagc agcccggggg ccccgctgtt gggagtgtgc    900

atttaactgt ttcatgcgct tgttggcgcg actgtggctc gagctggccc gcagacacgt    960

gggtttcatc actctgaggg gccacgtctg ttagtttcct atcattttgc cgtagtattt   1020

tttgaaaaag ggacatgtgt cctgtgggtc cctgcagtcg acatcatgtt tggctgggca   1080

tcgatgcctc ctttctggga ctcccggcac aactcccctc atccagggag ggaggcagct   1140

gctggggagg ggcttggcta ggtagttctg tgtggcggtg gtcattcccc tcattaaaca   1200

ccagttcttg gtgacgccag gggctggtag gtcattcaaa gctgtggcca gctcacgcct   1260

gcttcctccc tccctgccct gctgaatcct aaagctgtgc ctatatctgt gatttgaatg   1320

agggagccct ttggggcaaa ttcaggtgcc cccattgcct caggctggcc ctggtcccag   1380

gtggcagcgg ttgaggaggg gtacagggct ctcaagcctg aggttttctt ctctgggctt   1440

aattttctct tggggtacgt gcctgacagt gtttaaggtg tccgttgaac tggagttgca   1500

gacttttaaa tagatgaccc cttcagatca tctgtgccta cctcctgccc atcaggcgtc   1560

tacactgtca ctcagacacc tgtggcatgt ggaggagact gccctgtcct gagcctggaa   1620

aatgtgaaac tgtctcctgc aacctgctgg gcatgtgggc ctggctgtgt tcaattgcaa   1680

gaacaatttt tatgaaatgg attaaagctt gtttttt                            1717


<210>  808
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  808

Met Gln Glu Ile Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu 
1               5                   10                  15      


Ile Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly 
            20                  25                  30          


Met Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala 
        35                  40                  45              


Cys Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys 
    50                  55                  60                  


Thr Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp 
65                  70                  75                  80  


Gln Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys 
                85                  90                  95      


Tyr Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe 
            100                 105                 110         


Leu His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp 
        115                 120                 125             


Arg Gly Phe Cys Lys His Gly Pro Leu Cys Arg His Arg His Thr Arg 
    130                 135                 140                 


Arg Val Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro 
145                 150                 155                 160 


Ser Cys Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr 
                165                 170                 175     


Glu Gln Pro Pro Leu Pro Gln Gln Thr Gln Pro Pro Ala Lys Gln Ser 
            180                 185                 190         


Asn Asn Pro Pro Leu Gln Arg Ser Ser Ser Leu Ile Gln Leu Thr Ser 
        195                 200                 205             


Gln Asn Ser Ser Pro Asn Gln Gln Arg Thr Pro Gln Val Ile Gly Val 
    210                 215                 220                 


Met Gln Ser Gln Asn Ser Ser Ala Gly Asn Arg Gly Pro Arg Pro Leu 
225                 230                 235                 240 


Glu Gln Val Thr Cys Tyr Lys Cys Gly Glu Lys Gly His Tyr Ala Asn 
                245                 250                 255     


Arg Cys Thr Lys Gly His Leu Ala Phe Leu Ser Gly Gln 
            260                 265                 


<210>  809
<211>  395
<212>  DNA
<213>  Homosapiens

<400>  809
gcagccctcg cgcggtccgg cacagcggac accaggactc caaaatggcg tcagttggtg     60

agtgtccggc cccagtacca gtgaaggaca agaaacttct ggaggtcaaa ctgggggagc    120

tgccaagctg gatcttgatg cgggacttca gtcctagtgg cattttcgga gcgtttcaaa    180

gagagcacga gcggctccgc aaataccact gaagaggaca cactctgcac ccccccaccc    240

cacgaccttg gcccgagccc ctccgtgagg aacacaatct caatcgttgc tgaatccttt    300

catatcctaa taggaattaa cctccaaata aaacatgact ggtacgtgtg ctgattgcct    360

gcctgtctgc cgtagccaaa aaaaaaaaaa aaaaa                               395


<210>  810
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  810

Met Ala Ser Val Gly Glu Cys Pro Ala Pro Val Pro Val Lys Asp Lys 
1               5                   10                  15      


Lys Leu Leu Glu Val Lys Leu Gly Glu Leu Pro Ser Trp Ile Leu Met 
            20                  25                  30          


Arg Asp Phe Ser Pro Ser Gly Ile Phe Gly Ala Phe Gln Arg Glu His 
        35                  40                  45              


Glu Arg Leu Arg Lys Tyr His 
    50                  55  


<210>  811
<211>  494
<212>  DNA
<213>  Homosapiens

<400>  811
gcagccctcg cgcggtccgg cacagcggac accaggactc caaaatggcg tcagttgtac     60

cagtgaagga caagaaactt ctggaggtca aactggggga gctgccaagc tggatcttga    120

tgcgggactt cagtcctagt ggcattttcg gagcgtttca aagaggttac taccggtact    180

acaacaagta catcaatgtg aagaagggga gcatctcggg gattaccatg gtgctggcat    240

gctacgtgct ctttagctac tccttttcct acaagcatct caagcacgag cggctccgca    300

aataccactg aagaggacac actctgcacc cccccacccc acgaccttgg cccgagcccc    360

tccgtgagga acacaatctc aatcgttgct gaatcctttc atatcctaat aggaattaac    420

ctccaaataa aacatgactg gtacgtgtgc tgattgcctg cctgtctgcc gtagccaaaa    480

aaaaaaaaaa aaaa                                                      494


<210>  812
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  812

Met Ala Ser Val Val Pro Val Lys Asp Lys Lys Leu Leu Glu Val Lys 
1               5                   10                  15      


Leu Gly Glu Leu Pro Ser Trp Ile Leu Met Arg Asp Phe Ser Pro Ser 
            20                  25                  30          


Gly Ile Phe Gly Ala Phe Gln Arg Gly Tyr Tyr Arg Tyr Tyr Asn Lys 
        35                  40                  45              


Tyr Ile Asn Val Lys Lys Gly Ser Ile Ser Gly Ile Thr Met Val Leu 
    50                  55                  60                  


Ala Cys Tyr Val Leu Phe Ser Tyr Ser Phe Ser Tyr Lys His Leu Lys 
65                  70                  75                  80  


His Glu Arg Leu Arg Lys Tyr His 
                85              


<210>  813
<211>  512
<212>  DNA
<213>  Homosapiens

<400>  813
gcagccctcg cgcggtccgg cacagcggac accaggactc caaaatggcg tcagttggtg     60

agtgtccggc cccagtacca gtgaaggaca agaaacttct ggaggtcaaa ctgggggagc    120

tgccaagctg gatcttgatg cgggacttca gtcctagtgg cattttcgga gcgtttcaaa    180

gaggttacta ccggtactac aacaagtaca tcaatgtgaa gaaggggagc atctcgggga    240

ttaccatggt gctggcatgc tacgtgctct ttagctactc cttttcctac aagcatctca    300

agcacgagcg gctccgcaaa taccactgaa gaggacacac tctgcacccc cccaccccac    360

gaccttggcc cgagcccctc cgtgaggaac acaatctcaa tcgttgctga atcctttcat    420

atcctaatag gaattaacct ccaaataaaa catgactggt acgtgtgctg attgcctgcc    480

tgtctgccgt agccaaaaaa aaaaaaaaaa aa                                  512


<210>  814
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  814

Met Ala Ser Val Gly Glu Cys Pro Ala Pro Val Pro Val Lys Asp Lys 
1               5                   10                  15      


Lys Leu Leu Glu Val Lys Leu Gly Glu Leu Pro Ser Trp Ile Leu Met 
            20                  25                  30          


Arg Asp Phe Ser Pro Ser Gly Ile Phe Gly Ala Phe Gln Arg Gly Tyr 
        35                  40                  45              


Tyr Arg Tyr Tyr Asn Lys Tyr Ile Asn Val Lys Lys Gly Ser Ile Ser 
    50                  55                  60                  


Gly Ile Thr Met Val Leu Ala Cys Tyr Val Leu Phe Ser Tyr Ser Phe 
65                  70                  75                  80  


Ser Tyr Lys His Leu Lys His Glu Arg Leu Arg Lys Tyr His 
                85                  90                  


<210>  815
<211>  547
<212>  DNA
<213>  Homosapiens

<400>  815
cgagaggctc tgaggctgcc agagtggttg tgtctgttcc tccggtaagg ggtgattcgc     60

cgaggggcgc ggaccagaca gacctcgggt caggcccggg aaccccgaga ggagagccca    120

gcccctggtg gaggcggctt ggcggagatt cggagccgtc agcagctcag ccagacgtcc    180

aggatcccac cccttgcaaa agaccaggcc gtggaagcca tgttcccacc agccaggggg    240

aaggagctgc tctcgtttga ggatgtggcg atgtacttca ccagagagga gtggggccac    300

ctcaactggg gtcagaagga cctctaccga gatgtgatgt tggagaacta caggaacatg    360

gtcttgctgg tttatttcca gtttgatgct gcaataccac tgtgctgaac gtctctggca    420

cattcatctt ggttgcaatt gtactttagg ctatatttct aagagcgaaa tgaccacagc    480

caaaggtatg aacattgttc aggctttcaa taaagactgc cagatattta caaaaaaaaa    540

aaaaaaa                                                              547


<210>  816
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  816

Met Phe Pro Pro Ala Arg Gly Lys Glu Leu Leu Ser Phe Glu Asp Val 
1               5                   10                  15      


Ala Met Tyr Phe Thr Arg Glu Glu Trp Gly His Leu Asn Trp Gly Gln 
            20                  25                  30          


Lys Asp Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Met Val 
        35                  40                  45              


Leu Leu Val Tyr Phe Gln Phe Asp Ala Ala Ile Pro Leu Cys 
    50                  55                  60          


<210>  817
<211>  1654
<212>  DNA
<213>  Homosapiens

<400>  817
cgagaggctc tgaggctgcc agagtggttg tgtctgttcc tccggtaagg ggtgattcgc     60

cgaggggcgc ggaccagaca gacctcgggt caggcccggg aaccccgaga ggagagccca    120

gcccctggtg gaggcggctt ggcggagatt cggagccgtc agcagctcag ccagacgtcc    180

aggatcccac cccttgcaaa agaccaggcc gtggaagcca tgttcccacc agccaggggg    240

aaggagctgc tctcgtttga ggatgtggcg atgtacttca ccagagagga gtggggccac    300

ctcaactggg gtcagaagga cctctaccga gatgtgatgt tggagaacta caggaacatg    360

gtcttgctgg gatttcagtt tcccaaacct gagatgatct gtcagctgga gaactgggac    420

gagcagtgga tcctggatct accgagaact gggaatagga aggcttccgg tagtgcttgc    480

ccaggttctg aagccagaca caagatgaaa aagctaactc caaaacagaa attttctgaa    540

gatttagagt catataagat atcagtggta atgcaggaat cagctgagaa actttcagaa    600

aagttacata agtgtaaaga atttgtggac agttgcaggc ttactttccc tactagtggt    660

gatgaataca gcaggggctt ccttcaaaac cttaacctta ttcaagatca gaatgcgcaa    720

acaaggtgga agcagggcag atatgatgag gatggcaaac ccttcaatca aagatctttg    780

cttttggggc atgagcgaat tctcacaaga gcaaagtctt atgaatgcag tgaatgtgga    840

aaagtcatta ggcgtaaggc atggtttgat caacatcaaa gaattcactt tttagagaat    900

ccttttgagt gtaaggtctg tgggcaagcc ttcagacagc ggtcagctct tacggtccat    960

aaacagtgtc acctgcaaaa caagccatac agatgtcatg actgtggaaa gtgttttcgg   1020

cagctcgcgt atcttgttga acataagagg attcacacca aagaaaaacc ttataaatgt   1080

agcaaatgtg aaaaaacgtt tagtcagaat tcaaccctta ttcgacatca ggtgatccat   1140

agtggagaaa aacgccataa atgccttgag tgtggaaaag cctttggccg gcattcaacc   1200

cttctatgtc atcaacagat tcacagtaaa ccgaacaccc ataaatgcag tgaatgtgga   1260

cagtcctttg gtaggaatgt ggatctcatt cagcatcaaa gaatccatac aaaggaggaa   1320

ttctttcaat gtggagaatg tgggaaaacg tttagtttta agaggaatct ttttcgacat   1380

caggtcattc acactggaag ccaaccctac caatgtgtca tatgtggaaa atctttcaag   1440

tggcacacaa gctttattaa gcaccagggc actcacaaag gacagatatc cacatgatgt   1500

taattggaaa gcagtcattg gagaactaga acttataaac ctctacttca agtgtgtatc   1560

acgtaattgt ttccatgaaa agcaataaat gtaacaaagg gttaaaaaaa aaaaaaaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               1654


<210>  818
<211>  425
<212>  PRT
<213>  Homosapiens

<400>  818

Met Phe Pro Pro Ala Arg Gly Lys Glu Leu Leu Ser Phe Glu Asp Val 
1               5                   10                  15      


Ala Met Tyr Phe Thr Arg Glu Glu Trp Gly His Leu Asn Trp Gly Gln 
            20                  25                  30          


Lys Asp Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Met Val 
        35                  40                  45              


Leu Leu Gly Phe Gln Phe Pro Lys Pro Glu Met Ile Cys Gln Leu Glu 
    50                  55                  60                  


Asn Trp Asp Glu Gln Trp Ile Leu Asp Leu Pro Arg Thr Gly Asn Arg 
65                  70                  75                  80  


Lys Ala Ser Gly Ser Ala Cys Pro Gly Ser Glu Ala Arg His Lys Met 
                85                  90                  95      


Lys Lys Leu Thr Pro Lys Gln Lys Phe Ser Glu Asp Leu Glu Ser Tyr 
            100                 105                 110         


Lys Ile Ser Val Val Met Gln Glu Ser Ala Glu Lys Leu Ser Glu Lys 
        115                 120                 125             


Leu His Lys Cys Lys Glu Phe Val Asp Ser Cys Arg Leu Thr Phe Pro 
    130                 135                 140                 


Thr Ser Gly Asp Glu Tyr Ser Arg Gly Phe Leu Gln Asn Leu Asn Leu 
145                 150                 155                 160 


Ile Gln Asp Gln Asn Ala Gln Thr Arg Trp Lys Gln Gly Arg Tyr Asp 
                165                 170                 175     


Glu Asp Gly Lys Pro Phe Asn Gln Arg Ser Leu Leu Leu Gly His Glu 
            180                 185                 190         


Arg Ile Leu Thr Arg Ala Lys Ser Tyr Glu Cys Ser Glu Cys Gly Lys 
        195                 200                 205             


Val Ile Arg Arg Lys Ala Trp Phe Asp Gln His Gln Arg Ile His Phe 
    210                 215                 220                 


Leu Glu Asn Pro Phe Glu Cys Lys Val Cys Gly Gln Ala Phe Arg Gln 
225                 230                 235                 240 


Arg Ser Ala Leu Thr Val His Lys Gln Cys His Leu Gln Asn Lys Pro 
                245                 250                 255     


Tyr Arg Cys His Asp Cys Gly Lys Cys Phe Arg Gln Leu Ala Tyr Leu 
            260                 265                 270         


Val Glu His Lys Arg Ile His Thr Lys Glu Lys Pro Tyr Lys Cys Ser 
        275                 280                 285             


Lys Cys Glu Lys Thr Phe Ser Gln Asn Ser Thr Leu Ile Arg His Gln 
    290                 295                 300                 


Val Ile His Ser Gly Glu Lys Arg His Lys Cys Leu Glu Cys Gly Lys 
305                 310                 315                 320 


Ala Phe Gly Arg His Ser Thr Leu Leu Cys His Gln Gln Ile His Ser 
                325                 330                 335     


Lys Pro Asn Thr His Lys Cys Ser Glu Cys Gly Gln Ser Phe Gly Arg 
            340                 345                 350         


Asn Val Asp Leu Ile Gln His Gln Arg Ile His Thr Lys Glu Glu Phe 
        355                 360                 365             


Phe Gln Cys Gly Glu Cys Gly Lys Thr Phe Ser Phe Lys Arg Asn Leu 
    370                 375                 380                 


Phe Arg His Gln Val Ile His Thr Gly Ser Gln Pro Tyr Gln Cys Val 
385                 390                 395                 400 


Ile Cys Gly Lys Ser Phe Lys Trp His Thr Ser Phe Ile Lys His Gln 
                405                 410                 415     


Gly Thr His Lys Gly Gln Ile Ser Thr 
            420                 425 


<210>  819
<211>  2259
<212>  DNA
<213>  Homosapiens

<400>  819
gtaggcgcaa agctgaggaa aggagagtgt ggagaggggc ctggtgtggt ggggcccggt     60

gtttgggacc ggagggtgtt gacggctgat gagttccttg ggtttgctct ttcttcacct    120

gaaaagaaga ctccaggaag ggcagcacat gccggagaaa gatgaattcc agcttgaccg    180

cccagaggcg cggcagtgac gccgagttgg gaccctgggt gatggctgcg aggtccaagg    240

acgcggcgcc gtcccaacgc gacggacttt tgcccgtgaa agtggaggaa gactcacccg    300

gaagttggga gcccaactat cccgcggctt cgccggaccc cgaaacttct cgactgcact    360

ttaggcagct gcgttaccag gaggtggctg gaccggaaga ggcgctgagc cggctccgag    420

aactctgtcg tcggtggctg agacccgagc tgctctccaa ggagcagatc ctggagctgc    480

tggtgctgga gcagttcctc accatcctgc ccgaggagct tcaagcctgg gtgcgagagc    540

actgcccaga gagcggggag gaggcggtgg ccgtggtgcg ggctctgcag cgagcgctcg    600

atggaacctc atcccagggg atggtgactt tcgaggacac ggctgtgtct ctaacctggg    660

aggagtggga gcgcctggac ccagcacgga gggacttctg cagagagagt gcgcagaagg    720

attccgggag cacagttccg ccgagtttgg aaagcagagt ggagaacaaa gagttgattc    780

caatgcaaca aattttagaa gaagcggagc cacaggggca actacaagaa gcgttccagg    840

ggaagcgccc cctgttttct aagtgtggca gtacccatga ggacagggtg gaaaagcagt    900

ccggagaccc cttgcccctg aaacttgaaa attctcctga agcagaagga ctcaacagca    960

tctcagatgt caataagaat ggttccatag aaggggaaga ctctaaaaat aatgaattgc   1020

agaacagtgc caggtgttcc aaccttgttc tatgtcagca catcccgaaa gcagagaggc   1080

ccactgacag tgaggaacac gggaacaagt gcaagcaaag tttccacatg gtgacgtggc   1140

acgtgctgaa acctcacaag tctgacagtg gagacagttt ccatcattcc agcctttttg   1200

agacccagag gcagctccat gaagaaagac cttataaatg tggtaactgt gggaagagtt   1260

tcaaacaacg ctctgacctc tttagacacc agagaatcca cacaggtgag aaaccctatg   1320

gctgccaaga atgtgggaaa agcttcagcc agagtgctgc cctgaccaag caccagagga   1380

cacacacagg cgagaagccg tacacctgtc tgaaatgtgg ggagcgcttc aggcagaatt   1440

cacacctaaa tcgtcatcaa agtacccaca gtagagacaa acattttaaa tgtgaggaat   1500

gcggggaaac ctgtcatatt tccaaccttt ttagacatca gagactacat aaaggggaaa   1560

gaccctataa gtgtgaagaa tgcgagaaga gcttcaaaca gcgctctgac ctctttaaac   1620

accacagaat ccacactggg gagaagccct atggatgttc cgtctgtggg aaacgcttca   1680

atcagagtgc aaccctcatt aaacaccaga gaattcacac tggggaaaag ccttacaaat   1740

gtcttgaatg tggggaaaga tttagacaaa gtacacacct tatccgacac caaagaattc   1800

atcaaaataa agtgctgtcg gctgggcgtg gtggctcacg cctataatcc cagcactttg   1860

ggaggccaag gcaggcagat catttgagat caggagtttg aaaccagcct ggccaacatg   1920

gtaaaatcct gtctctacta aaaatacaaa aatgagccgg gcatggtggt gcatgcctgt   1980

aagcccagct attcgggagg ctgaggtagg agaatcactt gaacccagga ggcggaagtt   2040

gcagtgagct gagatcatgc cactgcactc cagcctgggc aacagagcga gactccatct   2100

caaaaaagaa ataaagtgct gtcattttga tatgtttcta tgtgaaaaaa aaaaaaaaaa   2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          2259


<210>  820
<211>  561
<212>  PRT
<213>  Homosapiens

<400>  820

Met Asn Ser Ser Leu Thr Ala Gln Arg Arg Gly Ser Asp Ala Glu Leu 
1               5                   10                  15      


Gly Pro Trp Val Met Ala Ala Arg Ser Lys Asp Ala Ala Pro Ser Gln 
            20                  25                  30          


Arg Asp Gly Leu Leu Pro Val Lys Val Glu Glu Asp Ser Pro Gly Ser 
        35                  40                  45              


Trp Glu Pro Asn Tyr Pro Ala Ala Ser Pro Asp Pro Glu Thr Ser Arg 
    50                  55                  60                  


Leu His Phe Arg Gln Leu Arg Tyr Gln Glu Val Ala Gly Pro Glu Glu 
65                  70                  75                  80  


Ala Leu Ser Arg Leu Arg Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu 
                85                  90                  95      


Leu Leu Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe 
            100                 105                 110         


Leu Thr Ile Leu Pro Glu Glu Leu Gln Ala Trp Val Arg Glu His Cys 
        115                 120                 125             


Pro Glu Ser Gly Glu Glu Ala Val Ala Val Val Arg Ala Leu Gln Arg 
    130                 135                 140                 


Ala Leu Asp Gly Thr Ser Ser Gln Gly Met Val Thr Phe Glu Asp Thr 
145                 150                 155                 160 


Ala Val Ser Leu Thr Trp Glu Glu Trp Glu Arg Leu Asp Pro Ala Arg 
                165                 170                 175     


Arg Asp Phe Cys Arg Glu Ser Ala Gln Lys Asp Ser Gly Ser Thr Val 
            180                 185                 190         


Pro Pro Ser Leu Glu Ser Arg Val Glu Asn Lys Glu Leu Ile Pro Met 
        195                 200                 205             


Gln Gln Ile Leu Glu Glu Ala Glu Pro Gln Gly Gln Leu Gln Glu Ala 
    210                 215                 220                 


Phe Gln Gly Lys Arg Pro Leu Phe Ser Lys Cys Gly Ser Thr His Glu 
225                 230                 235                 240 


Asp Arg Val Glu Lys Gln Ser Gly Asp Pro Leu Pro Leu Lys Leu Glu 
                245                 250                 255     


Asn Ser Pro Glu Ala Glu Gly Leu Asn Ser Ile Ser Asp Val Asn Lys 
            260                 265                 270         


Asn Gly Ser Ile Glu Gly Glu Asp Ser Lys Asn Asn Glu Leu Gln Asn 
        275                 280                 285             


Ser Ala Arg Cys Ser Asn Leu Val Leu Cys Gln His Ile Pro Lys Ala 
    290                 295                 300                 


Glu Arg Pro Thr Asp Ser Glu Glu His Gly Asn Lys Cys Lys Gln Ser 
305                 310                 315                 320 


Phe His Met Val Thr Trp His Val Leu Lys Pro His Lys Ser Asp Ser 
                325                 330                 335     


Gly Asp Ser Phe His His Ser Ser Leu Phe Glu Thr Gln Arg Gln Leu 
            340                 345                 350         


His Glu Glu Arg Pro Tyr Lys Cys Gly Asn Cys Gly Lys Ser Phe Lys 
        355                 360                 365             


Gln Arg Ser Asp Leu Phe Arg His Gln Arg Ile His Thr Gly Glu Lys 
    370                 375                 380                 


Pro Tyr Gly Cys Gln Glu Cys Gly Lys Ser Phe Ser Gln Ser Ala Ala 
385                 390                 395                 400 


Leu Thr Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys 
                405                 410                 415     


Leu Lys Cys Gly Glu Arg Phe Arg Gln Asn Ser His Leu Asn Arg His 
            420                 425                 430         


Gln Ser Thr His Ser Arg Asp Lys His Phe Lys Cys Glu Glu Cys Gly 
        435                 440                 445             


Glu Thr Cys His Ile Ser Asn Leu Phe Arg His Gln Arg Leu His Lys 
    450                 455                 460                 


Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Glu Lys Ser Phe Lys Gln 
465                 470                 475                 480 


Arg Ser Asp Leu Phe Lys His His Arg Ile His Thr Gly Glu Lys Pro 
                485                 490                 495     


Tyr Gly Cys Ser Val Cys Gly Lys Arg Phe Asn Gln Ser Ala Thr Leu 
            500                 505                 510         


Ile Lys His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Leu 
        515                 520                 525             


Glu Cys Gly Glu Arg Phe Arg Gln Ser Thr His Leu Ile Arg His Gln 
    530                 535                 540                 


Arg Ile His Gln Asn Lys Val Leu Ser Ala Gly Arg Gly Gly Ser Arg 
545                 550                 555                 560 


Leu 
    


<210>  821
<211>  4312
<212>  DNA
<213>  Homosapiens

<400>  821
gggctgtttg aatggctttg ggatggagca ggggagagag tggctccgtt tgcctccccg     60

ctttggtgat gctgtgcgag cggcttcggg ggccctggag acgtccgagt cactgagggt    120

gggctgggac tcggggcccg cgtcccatct ccccgccgat tggtccgccc cccgtgcgag    180

tgtaacacag ccagcctcga agacttccct ctgagttgga atgataatga ccgaatcccg    240

agaagttata gacttagacc ccccagctga gacttcccag gagcaggaag accttttcat    300

agtgaaggtg gaagaagaag actgcacctg gatgcaggag tacaacccgc caacgtttga    360

gactttttac cagcgcttca ggcacttcca gtaccatgag gcttcaggac cccgggaggc    420

tctcagccaa ctccgggtgc tctgctgtga gtggctgagg cccgagctgc acacgaagga    480

gcagatcctg gagctgctgg tgctggagca gttcctgacc atcctgcctg aagagttcca    540

gccctgggtg agggaacatc accctgaaag tggagaagag gcggtggccg tgatagaaaa    600

tatacagcga gaacttgagg aacgcagaca gcagattgtt gcctgccctg atgtgcttcc    660

tcggaagatg gcaacacctg gagcagtgca ggagtcctgc agcccccatc ccctgaccgt    720

ggacacccag cctgagcaag cgccacagaa gcctcgtctc ctggaggaaa atgcccttcc    780

tgttctccaa gttccttccc ttcccctgaa ggacagccag gagctgacag cttcacttct    840

ctcaactggg tcccagaagt tggtgaaaat tgaagaggtg gctgatgtgg ctgtatcctt    900

catcctggag gaatgggggc atttggacca gtcccagaag tccctttata gggatgacag    960

gaaggagaac tatgggagta ttacttccat gggttatgag tccagggaca atatggagct   1020

catagtgaag cagatttctg atgactctga atcacactgg gtggcgccag aacacaccga   1080

aaggagcgtt cctcaggatc cagactttgc agaagtcagt gaccttaaag gcatggtaca   1140

aaggtggcag gtcaacccca ctgtggggaa atcaaggcag aatccttccc agaaaaggga   1200

tctggatgca atcacagaca tcagccctaa gcaaagcaca catggcgaga gagggcacag   1260

atgcagcgat tgtggcaaat tcttcctcca agcctcaaac tttattcagc atcggcgcat   1320

ccacactgga gaaaaaccgt ttaagtgcgg agaatgtggg aagagctaca atcagcgggt   1380

gcacctcacc cagcaccagc gcgtccacac aggggagaaa ccctacaaat gtcaggtgtg   1440

cggaaaggct ttccgggtga gttcccacct ggttcagcac cacagtgtcc acagcggaga   1500

gaggccctat ggctgcaatg agtgtgggaa gaacttcggt cgccattcgc atctgatcga   1560

acacctaaaa cgccacttca gggagaaatc ccagagatgc agtgacaaaa gaagtaagaa   1620

cacaaaatta agtgttaaga agaaaatttc agaatattca gaagcagaca tggaactatc   1680

tggaaaaacc caaagaaatg tttctcaagt tcaagatttt ggagaaggct gtgagtttca   1740

aggcaagctg gatagaaagc agggaattcc catgaaagag atactaggac aaccatcttc   1800

aaagaggatg aactacagtg aagtcccata tgtccacaaa aaatcctcca ctggagagag   1860

accacataaa tgtaacgagt gtgggaaaag cttcattcag agtgcacatc ttattcaaca   1920

tcaaagaata cacactgggg agaaaccatt caggtgtgag gaatgtggga aaagctacaa   1980

ccaacgcgtg cacctaactc agcatcagcg cgtccacaca ggtgagaagc cctacacctg   2040

tcccttatgt gggaaagcct tcagagtgag gtcccacctt gttcagcatc agagcgtgca   2100

cagtggggag agacccttca agtgtaacga atgtgggaaa ggctttggga ggcgttccca   2160

cctggctgga catcttcgac tccactcccg agagaaatcc catcagtgtc gtgaatgtgg   2220

ggaaatcttt tttcagtacg ttagcctaat tgaacatcag gtgctccaca tgggtcagaa   2280

aaatgaaaaa aatggcatct gtgaggaagc atatagttgg aacttgacag tgattgaaga   2340

caagaagatt gagttacaag agcagcctta tcagtgtgat atctgtggaa aagcctttgg   2400

ttatagctca gacctcattc agcattacag aactcataca gcagagaagc cctatcaatg   2460

tgatatatgt agagaaaatg ttggccagtg ttcccacacc aaacaacatc aaaaaatcta   2520

ctccagcaca aaatcccatc aatgtcatga atgtggcaga ggcttcactc tgaagtcaca   2580

tcttaatcaa catcagagaa tccatactgg tgagaaacct tttcaatgta aagaatgtgg   2640

aatgaatttc agctggagtt gtagcctctt taaacacctg agaagccatg agaggacaga   2700

tcccataaat accttaagtg tagaggggtc tctgttgtag aatagctctt aattttagag   2760

aaaccttcct ggagggaaac catactccta taatgagcaa agtaacaact tcaagcattt   2820

ttccagcgtt accatcaaac tcacaaatag gttgaaatcc tttagttata actcagcctt   2880

taggaacacc ggagaaccca caataataga aatcttttcg tgttccccat tgagaaatgc   2940

tttagttagc atcttcatgc ttggaaatct agacaagaag agaatccatg gatggacatg   3000

gtcgaggaat tcggaaagcc tgcagttgac attcagtctt cacttgaaac tcaaaactga   3060

cactaggaac agcttcatga gttcagtaga agtaagcttt atttgtagct tctgccttgt   3120

ttgacggcgt atctattcag ggaagcgcac agtaaaagaa ttccttagca tgatgtctgt   3180

tttggtacct cagcaatgaa ccttttctag aaattattat tccaaccact agaataccct   3240

agtcactatt cccactttga gcattaaccc ctttgaaaag aaatggactt aaagtatctc   3300

tgttttggca aaattcaggt tcaggggctg gatggtatgt gtttctgctg ccttattcaa   3360

tccaccactt ctctgtgaaa cactctacct tgtttttggt ttgattctac tgatgtcagg   3420

gtttagccgg tagaaggagt agttcagttt gtcaattcag gagaaactgt actggtcagt   3480

cacatcttac ggcgaaggga gagggacctt aggggagcag agaagacagg caaagttgtg   3540

gactgtttga tcttgtatta cccacaggaa tgagggcagc taaacccata gaaggagttg   3600

gaccaaggcg aattacgagt cctggtccca gcagtatgtg tgctgacttc tgggtgcccc   3660

agaaatagac ctctcctgta gagtggtgat atacagaatg agtttcagtt tgcattgcag   3720

ctgggattga aagtaatcag tcgtgagcag gcaggcagga ggtcctgtta gccctgcctt   3780

ccaggaaggt tggggtggga gttttgagtg ggaaagagga tgacatgtgt gagagagttc   3840

tgagcctgtt tgctagggag agtgagtgag tgctcttggg cactgctcag gccgtttctg   3900

ctgacttgcc tggcttacaa taaatgccca ataaatattt gttgaccata tgtgttgtac   3960

actgtggtgc cctgtccagt cccctctacc aagctgagac ccccatcccc agctgctctg   4020

agtttgggct gcaagtgctc acagctcttg ttctccagaa actggagaat tgccctcagg   4080

agatgagagc catctcacct cacccaggag tcacttcctc tctacacccc aacacctggt   4140

tcatttgatt aaagcggaga aaactccagg gtgctatgac tgctctggca cccttggatc   4200

aggccaagct agactttttc tgagccttca tccgtgctaa gctctctccc ttctctatcc   4260

tgtttcattc cctccctcaa aggcgtttcc caaataaatc acactgtcaa tc           4312


<210>  822
<211>  839
<212>  PRT
<213>  Homosapiens

<400>  822

Met Ile Met Thr Glu Ser Arg Glu Val Ile Asp Leu Asp Pro Pro Ala 
1               5                   10                  15      


Glu Thr Ser Gln Glu Gln Glu Asp Leu Phe Ile Val Lys Val Glu Glu 
            20                  25                  30          


Glu Asp Cys Thr Trp Met Gln Glu Tyr Asn Pro Pro Thr Phe Glu Thr 
        35                  40                  45              


Phe Tyr Gln Arg Phe Arg His Phe Gln Tyr His Glu Ala Ser Gly Pro 
    50                  55                  60                  


Arg Glu Ala Leu Ser Gln Leu Arg Val Leu Cys Cys Glu Trp Leu Arg 
65                  70                  75                  80  


Pro Glu Leu His Thr Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu 
                85                  90                  95      


Gln Phe Leu Thr Ile Leu Pro Glu Glu Phe Gln Pro Trp Val Arg Glu 
            100                 105                 110         


His His Pro Glu Ser Gly Glu Glu Ala Val Ala Val Ile Glu Asn Ile 
        115                 120                 125             


Gln Arg Glu Leu Glu Glu Arg Arg Gln Gln Ile Val Ala Cys Pro Asp 
    130                 135                 140                 


Val Leu Pro Arg Lys Met Ala Thr Pro Gly Ala Val Gln Glu Ser Cys 
145                 150                 155                 160 


Ser Pro His Pro Leu Thr Val Asp Thr Gln Pro Glu Gln Ala Pro Gln 
                165                 170                 175     


Lys Pro Arg Leu Leu Glu Glu Asn Ala Leu Pro Val Leu Gln Val Pro 
            180                 185                 190         


Ser Leu Pro Leu Lys Asp Ser Gln Glu Leu Thr Ala Ser Leu Leu Ser 
        195                 200                 205             


Thr Gly Ser Gln Lys Leu Val Lys Ile Glu Glu Val Ala Asp Val Ala 
    210                 215                 220                 


Val Ser Phe Ile Leu Glu Glu Trp Gly His Leu Asp Gln Ser Gln Lys 
225                 230                 235                 240 


Ser Leu Tyr Arg Asp Asp Arg Lys Glu Asn Tyr Gly Ser Ile Thr Ser 
                245                 250                 255     


Met Gly Tyr Glu Ser Arg Asp Asn Met Glu Leu Ile Val Lys Gln Ile 
            260                 265                 270         


Ser Asp Asp Ser Glu Ser His Trp Val Ala Pro Glu His Thr Glu Arg 
        275                 280                 285             


Ser Val Pro Gln Asp Pro Asp Phe Ala Glu Val Ser Asp Leu Lys Gly 
    290                 295                 300                 


Met Val Gln Arg Trp Gln Val Asn Pro Thr Val Gly Lys Ser Arg Gln 
305                 310                 315                 320 


Asn Pro Ser Gln Lys Arg Asp Leu Asp Ala Ile Thr Asp Ile Ser Pro 
                325                 330                 335     


Lys Gln Ser Thr His Gly Glu Arg Gly His Arg Cys Ser Asp Cys Gly 
            340                 345                 350         


Lys Phe Phe Leu Gln Ala Ser Asn Phe Ile Gln His Arg Arg Ile His 
        355                 360                 365             


Thr Gly Glu Lys Pro Phe Lys Cys Gly Glu Cys Gly Lys Ser Tyr Asn 
    370                 375                 380                 


Gln Arg Val His Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Gln Val Cys Gly Lys Ala Phe Arg Val Ser Ser His 
                405                 410                 415     


Leu Val Gln His His Ser Val His Ser Gly Glu Arg Pro Tyr Gly Cys 
            420                 425                 430         


Asn Glu Cys Gly Lys Asn Phe Gly Arg His Ser His Leu Ile Glu His 
        435                 440                 445             


Leu Lys Arg His Phe Arg Glu Lys Ser Gln Arg Cys Ser Asp Lys Arg 
    450                 455                 460                 


Ser Lys Asn Thr Lys Leu Ser Val Lys Lys Lys Ile Ser Glu Tyr Ser 
465                 470                 475                 480 


Glu Ala Asp Met Glu Leu Ser Gly Lys Thr Gln Arg Asn Val Ser Gln 
                485                 490                 495     


Val Gln Asp Phe Gly Glu Gly Cys Glu Phe Gln Gly Lys Leu Asp Arg 
            500                 505                 510         


Lys Gln Gly Ile Pro Met Lys Glu Ile Leu Gly Gln Pro Ser Ser Lys 
        515                 520                 525             


Arg Met Asn Tyr Ser Glu Val Pro Tyr Val His Lys Lys Ser Ser Thr 
    530                 535                 540                 


Gly Glu Arg Pro His Lys Cys Asn Glu Cys Gly Lys Ser Phe Ile Gln 
545                 550                 555                 560 


Ser Ala His Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro 
                565                 570                 575     


Phe Arg Cys Glu Glu Cys Gly Lys Ser Tyr Asn Gln Arg Val His Leu 
            580                 585                 590         


Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys Pro 
        595                 600                 605             


Leu Cys Gly Lys Ala Phe Arg Val Arg Ser His Leu Val Gln His Gln 
    610                 615                 620                 


Ser Val His Ser Gly Glu Arg Pro Phe Lys Cys Asn Glu Cys Gly Lys 
625                 630                 635                 640 


Gly Phe Gly Arg Arg Ser His Leu Ala Gly His Leu Arg Leu His Ser 
                645                 650                 655     


Arg Glu Lys Ser His Gln Cys Arg Glu Cys Gly Glu Ile Phe Phe Gln 
            660                 665                 670         


Tyr Val Ser Leu Ile Glu His Gln Val Leu His Met Gly Gln Lys Asn 
        675                 680                 685             


Glu Lys Asn Gly Ile Cys Glu Glu Ala Tyr Ser Trp Asn Leu Thr Val 
    690                 695                 700                 


Ile Glu Asp Lys Lys Ile Glu Leu Gln Glu Gln Pro Tyr Gln Cys Asp 
705                 710                 715                 720 


Ile Cys Gly Lys Ala Phe Gly Tyr Ser Ser Asp Leu Ile Gln His Tyr 
                725                 730                 735     


Arg Thr His Thr Ala Glu Lys Pro Tyr Gln Cys Asp Ile Cys Arg Glu 
            740                 745                 750         


Asn Val Gly Gln Cys Ser His Thr Lys Gln His Gln Lys Ile Tyr Ser 
        755                 760                 765             


Ser Thr Lys Ser His Gln Cys His Glu Cys Gly Arg Gly Phe Thr Leu 
    770                 775                 780                 


Lys Ser His Leu Asn Gln His Gln Arg Ile His Thr Gly Glu Lys Pro 
785                 790                 795                 800 


Phe Gln Cys Lys Glu Cys Gly Met Asn Phe Ser Trp Ser Cys Ser Leu 
                805                 810                 815     


Phe Lys His Leu Arg Ser His Glu Arg Thr Asp Pro Ile Asn Thr Leu 
            820                 825                 830         


Ser Val Glu Gly Ser Leu Leu 
        835                 


<210>  823
<211>  4193
<212>  DNA
<213>  Homosapiens

<400>  823
gcgactcgcg ggtgtgacgt tgaagatgtc ggccttctga gccgactgcg gtggtcaaga     60

gtgtaacaca gccagcctcg aagacttccc tctgagttgg aatgataatg accgaatccc    120

gagaagttat agacttagac cccccagctg agacttccca ggagcaggaa gaccttttca    180

tagtgaaggt ggaagaagaa gactgcacct ggatgcagga gtacaacccg ccaacgtttg    240

agacttttta ccagcgcttc aggcacttcc agtaccatga ggcttcagga ccccgggagg    300

ctctcagcca actccgggtg ctctgctgtg agtggctgag gcccgagctg cacacgaagg    360

agcagatcct ggagctgctg gtgctggagc agttcctgac catcctgcct gaagagttcc    420

agccctgggt gagggaacat caccctgaaa gtggagaaga ggcggtggcc gtgatagaaa    480

atatacagcg agaacttgag gaacgcagac agcagattgt tgcctgccct gatgtgcttc    540

ctcggaagat ggcaacacct ggagcagtgc aggagtcctg cagcccccat cccctgaccg    600

tggacaccca gcctgagcaa gcgccacaga agcctcgtct cctggaggaa aatgcccttc    660

ctgttctcca agttccttcc cttcccctga aggacagcca ggagctgaca gcttcacttc    720

tctcaactgg gtcccagaag ttggtgaaaa ttgaagaggt ggctgatgtg gctgtatcct    780

tcatcctgga ggaatggggg catttggacc agtcccagaa gtccctttat agggatgaca    840

ggaaggagaa ctatgggagt attacttcca tgggttatga gtccagggac aatatggagc    900

tcatagtgaa gcagatttct gatgactctg aatcacactg ggtggcgcca gaacacaccg    960

aaaggagcgt tcctcaggat ccagactttg cagaagtcag tgaccttaaa ggcatggtac   1020

aaaggtggca ggtcaacccc actgtgggga aatcaaggca gaatccttcc cagaaaaggg   1080

atctggatgc aatcacagac atcagcccta agcaaagcac acatggcgag agagggcaca   1140

gatgcagcga ttgtggcaaa ttcttcctcc aagcctcaaa ctttattcag catcggcgca   1200

tccacactgg agaaaaaccg tttaagtgcg gagaatgtgg gaagagctac aatcagcggg   1260

tgcacctcac ccagcaccag cgcgtccaca caggggagaa accctacaaa tgtcaggtgt   1320

gcggaaaggc tttccgggtg agttcccacc tggttcagca ccacagtgtc cacagcggag   1380

agaggcccta tggctgcaat gagtgtggga agaacttcgg tcgccattcg catctgatcg   1440

aacacctaaa acgccacttc agggagaaat cccagagatg cagtgacaaa agaagtaaga   1500

acacaaaatt aagtgttaag aagaaaattt cagaatattc agaagcagac atggaactat   1560

ctggaaaaac ccaaagaaat gtttctcaag ttcaagattt tggagaaggc tgtgagtttc   1620

aaggcaagct ggatagaaag cagggaattc ccatgaaaga gatactagga caaccatctt   1680

caaagaggat gaactacagt gaagtcccat atgtccacaa aaaatcctcc actggagaga   1740

gaccacataa atgtaacgag tgtgggaaaa gcttcattca gagtgcacat cttattcaac   1800

atcaaagaat acacactggg gagaaaccat tcaggtgtga ggaatgtggg aaaagctaca   1860

accaacgcgt gcacctaact cagcatcagc gcgtccacac aggtgagaag ccctacacct   1920

gtcccttatg tgggaaagcc ttcagagtga ggtcccacct tgttcagcat cagagcgtgc   1980

acagtgggga gagacccttc aagtgtaacg aatgtgggaa aggctttggg aggcgttccc   2040

acctggctgg acatcttcga ctccactccc gagagaaatc ccatcagtgt cgtgaatgtg   2100

gggaaatctt ttttcagtac gttagcctaa ttgaacatca ggtgctccac atgggtcaga   2160

aaaatgaaaa aaatggcatc tgtgaggaag catatagttg gaacttgaca gtgattgaag   2220

acaagaagat tgagttacaa gagcagcctt atcagtgtga tatctgtgga aaagcctttg   2280

gttatagctc agacctcatt cagcattaca gaactcatac agcagagaag ccctatcaat   2340

gtgatatatg tagagaaaat gttggccagt gttcccacac caaacaacat caaaaaatct   2400

actccagcac aaaatcccat caatgtcatg aatgtggcag aggcttcact ctgaagtcac   2460

atcttaatca acatcagaga atccatactg gtgagaaacc ttttcaatgt aaagaatgtg   2520

gaatgaattt cagctggagt tgtagcctct ttaaacacct gagaagccat gagaggacag   2580

atcccataaa taccttaagt gtagaggggt ctctgttgta gaatagctct taattttaga   2640

gaaaccttcc tggagggaaa ccatactcct ataatgagca aagtaacaac ttcaagcatt   2700

tttccagcgt taccatcaaa ctcacaaata ggttgaaatc ctttagttat aactcagcct   2760

ttaggaacac cggagaaccc acaataatag aaatcttttc gtgttcccca ttgagaaatg   2820

ctttagttag catcttcatg cttggaaatc tagacaagaa gagaatccat ggatggacat   2880

ggtcgaggaa ttcggaaagc ctgcagttga cattcagtct tcacttgaaa ctcaaaactg   2940

acactaggaa cagcttcatg agttcagtag aagtaagctt tatttgtagc ttctgccttg   3000

tttgacggcg tatctattca gggaagcgca cagtaaaaga attccttagc atgatgtctg   3060

ttttggtacc tcagcaatga accttttcta gaaattatta ttccaaccac tagaataccc   3120

tagtcactat tcccactttg agcattaacc cctttgaaaa gaaatggact taaagtatct   3180

ctgttttggc aaaattcagg ttcaggggct ggatggtatg tgtttctgct gccttattca   3240

atccaccact tctctgtgaa acactctacc ttgtttttgg tttgattcta ctgatgtcag   3300

ggtttagccg gtagaaggag tagttcagtt tgtcaattca ggagaaactg tactggtcag   3360

tcacatctta cggcgaaggg agagggacct taggggagca gagaagacag gcaaagttgt   3420

ggactgtttg atcttgtatt acccacagga atgagggcag ctaaacccat agaaggagtt   3480

ggaccaaggc gaattacgag tcctggtccc agcagtatgt gtgctgactt ctgggtgccc   3540

cagaaataga cctctcctgt agagtggtga tatacagaat gagtttcagt ttgcattgca   3600

gctgggattg aaagtaatca gtcgtgagca ggcaggcagg aggtcctgtt agccctgcct   3660

tccaggaagg ttggggtggg agttttgagt gggaaagagg atgacatgtg tgagagagtt   3720

ctgagcctgt ttgctaggga gagtgagtga gtgctcttgg gcactgctca ggccgtttct   3780

gctgacttgc ctggcttaca ataaatgccc aataaatatt tgttgaccat atgtgttgta   3840

cactgtggtg ccctgtccag tcccctctac caagctgaga cccccatccc cagctgctct   3900

gagtttgggc tgcaagtgct cacagctctt gttctccaga aactggagaa ttgccctcag   3960

gagatgagag ccatctcacc tcacccagga gtcacttcct ctctacaccc caacacctgg   4020

ttcatttgat taaagcggag aaaactccag ggtgctatga ctgctctggc acccttggat   4080

caggccaagc tagacttttt ctgagccttc atccgtgcta agctctctcc cttctctatc   4140

ctgtttcatt ccctccctca aaggcgtttc ccaaataaat cacactgtca atc          4193


<210>  824
<211>  839
<212>  PRT
<213>  Homosapiens

<400>  824

Met Ile Met Thr Glu Ser Arg Glu Val Ile Asp Leu Asp Pro Pro Ala 
1               5                   10                  15      


Glu Thr Ser Gln Glu Gln Glu Asp Leu Phe Ile Val Lys Val Glu Glu 
            20                  25                  30          


Glu Asp Cys Thr Trp Met Gln Glu Tyr Asn Pro Pro Thr Phe Glu Thr 
        35                  40                  45              


Phe Tyr Gln Arg Phe Arg His Phe Gln Tyr His Glu Ala Ser Gly Pro 
    50                  55                  60                  


Arg Glu Ala Leu Ser Gln Leu Arg Val Leu Cys Cys Glu Trp Leu Arg 
65                  70                  75                  80  


Pro Glu Leu His Thr Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu 
                85                  90                  95      


Gln Phe Leu Thr Ile Leu Pro Glu Glu Phe Gln Pro Trp Val Arg Glu 
            100                 105                 110         


His His Pro Glu Ser Gly Glu Glu Ala Val Ala Val Ile Glu Asn Ile 
        115                 120                 125             


Gln Arg Glu Leu Glu Glu Arg Arg Gln Gln Ile Val Ala Cys Pro Asp 
    130                 135                 140                 


Val Leu Pro Arg Lys Met Ala Thr Pro Gly Ala Val Gln Glu Ser Cys 
145                 150                 155                 160 


Ser Pro His Pro Leu Thr Val Asp Thr Gln Pro Glu Gln Ala Pro Gln 
                165                 170                 175     


Lys Pro Arg Leu Leu Glu Glu Asn Ala Leu Pro Val Leu Gln Val Pro 
            180                 185                 190         


Ser Leu Pro Leu Lys Asp Ser Gln Glu Leu Thr Ala Ser Leu Leu Ser 
        195                 200                 205             


Thr Gly Ser Gln Lys Leu Val Lys Ile Glu Glu Val Ala Asp Val Ala 
    210                 215                 220                 


Val Ser Phe Ile Leu Glu Glu Trp Gly His Leu Asp Gln Ser Gln Lys 
225                 230                 235                 240 


Ser Leu Tyr Arg Asp Asp Arg Lys Glu Asn Tyr Gly Ser Ile Thr Ser 
                245                 250                 255     


Met Gly Tyr Glu Ser Arg Asp Asn Met Glu Leu Ile Val Lys Gln Ile 
            260                 265                 270         


Ser Asp Asp Ser Glu Ser His Trp Val Ala Pro Glu His Thr Glu Arg 
        275                 280                 285             


Ser Val Pro Gln Asp Pro Asp Phe Ala Glu Val Ser Asp Leu Lys Gly 
    290                 295                 300                 


Met Val Gln Arg Trp Gln Val Asn Pro Thr Val Gly Lys Ser Arg Gln 
305                 310                 315                 320 


Asn Pro Ser Gln Lys Arg Asp Leu Asp Ala Ile Thr Asp Ile Ser Pro 
                325                 330                 335     


Lys Gln Ser Thr His Gly Glu Arg Gly His Arg Cys Ser Asp Cys Gly 
            340                 345                 350         


Lys Phe Phe Leu Gln Ala Ser Asn Phe Ile Gln His Arg Arg Ile His 
        355                 360                 365             


Thr Gly Glu Lys Pro Phe Lys Cys Gly Glu Cys Gly Lys Ser Tyr Asn 
    370                 375                 380                 


Gln Arg Val His Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Gln Val Cys Gly Lys Ala Phe Arg Val Ser Ser His 
                405                 410                 415     


Leu Val Gln His His Ser Val His Ser Gly Glu Arg Pro Tyr Gly Cys 
            420                 425                 430         


Asn Glu Cys Gly Lys Asn Phe Gly Arg His Ser His Leu Ile Glu His 
        435                 440                 445             


Leu Lys Arg His Phe Arg Glu Lys Ser Gln Arg Cys Ser Asp Lys Arg 
    450                 455                 460                 


Ser Lys Asn Thr Lys Leu Ser Val Lys Lys Lys Ile Ser Glu Tyr Ser 
465                 470                 475                 480 


Glu Ala Asp Met Glu Leu Ser Gly Lys Thr Gln Arg Asn Val Ser Gln 
                485                 490                 495     


Val Gln Asp Phe Gly Glu Gly Cys Glu Phe Gln Gly Lys Leu Asp Arg 
            500                 505                 510         


Lys Gln Gly Ile Pro Met Lys Glu Ile Leu Gly Gln Pro Ser Ser Lys 
        515                 520                 525             


Arg Met Asn Tyr Ser Glu Val Pro Tyr Val His Lys Lys Ser Ser Thr 
    530                 535                 540                 


Gly Glu Arg Pro His Lys Cys Asn Glu Cys Gly Lys Ser Phe Ile Gln 
545                 550                 555                 560 


Ser Ala His Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro 
                565                 570                 575     


Phe Arg Cys Glu Glu Cys Gly Lys Ser Tyr Asn Gln Arg Val His Leu 
            580                 585                 590         


Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Thr Cys Pro 
        595                 600                 605             


Leu Cys Gly Lys Ala Phe Arg Val Arg Ser His Leu Val Gln His Gln 
    610                 615                 620                 


Ser Val His Ser Gly Glu Arg Pro Phe Lys Cys Asn Glu Cys Gly Lys 
625                 630                 635                 640 


Gly Phe Gly Arg Arg Ser His Leu Ala Gly His Leu Arg Leu His Ser 
                645                 650                 655     


Arg Glu Lys Ser His Gln Cys Arg Glu Cys Gly Glu Ile Phe Phe Gln 
            660                 665                 670         


Tyr Val Ser Leu Ile Glu His Gln Val Leu His Met Gly Gln Lys Asn 
        675                 680                 685             


Glu Lys Asn Gly Ile Cys Glu Glu Ala Tyr Ser Trp Asn Leu Thr Val 
    690                 695                 700                 


Ile Glu Asp Lys Lys Ile Glu Leu Gln Glu Gln Pro Tyr Gln Cys Asp 
705                 710                 715                 720 


Ile Cys Gly Lys Ala Phe Gly Tyr Ser Ser Asp Leu Ile Gln His Tyr 
                725                 730                 735     


Arg Thr His Thr Ala Glu Lys Pro Tyr Gln Cys Asp Ile Cys Arg Glu 
            740                 745                 750         


Asn Val Gly Gln Cys Ser His Thr Lys Gln His Gln Lys Ile Tyr Ser 
        755                 760                 765             


Ser Thr Lys Ser His Gln Cys His Glu Cys Gly Arg Gly Phe Thr Leu 
    770                 775                 780                 


Lys Ser His Leu Asn Gln His Gln Arg Ile His Thr Gly Glu Lys Pro 
785                 790                 795                 800 


Phe Gln Cys Lys Glu Cys Gly Met Asn Phe Ser Trp Ser Cys Ser Leu 
                805                 810                 815     


Phe Lys His Leu Arg Ser His Glu Arg Thr Asp Pro Ile Asn Thr Leu 
            820                 825                 830         


Ser Val Glu Gly Ser Leu Leu 
        835                 


<210>  825
<211>  2507
<212>  DNA
<213>  Homosapiens

<400>  825
gaaggccagg gggcttggat gtgagtctag tgctcctggt ccccaaagtc acaacccctt     60

ctatcccagc atcccagact tctccgggcg gggacagagt tggacgtgca tggctgtgtc    120

ctgcaatccc ctcgccacga ccgcccggga cggagtggaa gcgggtccgt gcccccgttc    180

ctcgcgccag cctcggcggt ggcaagcgct gtcccccagc agaggtgtcc ctggatacag    240

gatagcaaaa cctgatctca taaaacctag gtcacaaagg acagccctgc aaaacagacc    300

ctatttggat caagtgagcc agttcctgga acctgaataa tgactcctga atcaagggat    360

actacagatt tgtctccagg gggtacccag gagatggaag gcatcgtgat agtgaaggtg    420

gaggaggaag atgaagaaga ccattttcaa aaggaaagaa acaaagtaga gtcatcgcca    480

caagttctca gtcgctctac aactatgaat gagagagcct tattgtcatc gtatttagtt    540

gcatatagag tggcaaaaga gaaaatggct cacacagcgg ctgaaaaaat tatccttcca    600

gcatgtatgg acatggtacg gacaattttt gatgacaaat cagctgataa actaagaact    660

atacctctta gtgataatac aatatctcgt cgaatctgta cgattgcaaa acatttggaa    720

gcaatgctta ttacacggct gcagtccggt atagactttg caatccaact cgatgagagc    780

actgatattg caagttgtcc cacactcttg gtttatgtca gatatgtgtg gcaagatgat    840

tttgtagagg atctcttatg ttgtttaaat ttaaattcac atataactgg attagattta    900

tttactgaat tagaaaactg ccttcttggt cagtataaat taaactggaa acattgtaaa    960

ggaatttcaa gtgatggaac agcaaatatg accggaaaac acagcagact tactgaaaaa   1020

ttgttagaag caacccacaa caatgctgtt tggaatcact gttttattca tcgagaagct   1080

ttggtatcca aagaaatttc accaagtctg atggatgtat tgaaaaatgc agtgaaaact   1140

gttaatttta ttaaaggaag ctcactgaat agccgacttc tcgaaatatt ttgttcagag   1200

attggagtga accacaccca cttattgttt catacagaag ttcgttggct ttctcaagga   1260

aaagtattga gcagagtata tgaactcagg aacgagattt acatttttct cgttgaaaag   1320

caatctcatt tggcaaatat ttttgaagac gacatttggg taacaaaatt ggcatattta   1380

agtgatattt ttggcattct taatgaatta agcctgaaaa tgcaggggaa aaacaatgat   1440

atatttcagt atcttgaaca tattctagga ttccaaaaga cgttattatt gtggcaagca   1500

agacttaaaa gtaaccgccc tagctactat atgtttccaa cattattgca acacatcgaa   1560

gagaacatta ttaatgaaga ctgcttaaaa gaaataaaat tagagatatt gttgcatctc   1620

acttctttgt ctcaaacttt taattattac tttccggaag agaaatttga atcattaaag   1680

gaaaatattt ggatgaaaga tccatttgct tttcaaaacc cagaatcaat aattgagtta   1740

aacttggagc ctgaagaaga gaatgaatta ttgcagctca gttcatcatt cacactaaag   1800

aattattata agatattaag tttatcagca ttttggatta agattaaaga tgactttcca   1860

ctgctaagta ggaagagtat attgctgtta ctaccattca caactacata tttgtgtgaa   1920

ctaggatttt caatcttgac acggttaaaa acaaagaaga gaaataggct caatagtgca   1980

ccagatatgc gggtagcatt atcttcatgt gttcctgact ggaaggaact tatgaacaga   2040

caagcacacc catcacatta aatacaaact ttacaaaatt ctgtgtatag ccaggtgtgg   2100

tggcttacgc ctgtaatccc agcagtggga gaccgaggtg ggcagatcac ttgagttcaa   2160

gaccagcctg gccaacatgg tgaaacccca tctctactaa aaatagaaac cttagccagg   2220

cgtggtggca catgcctgca gtcccagtta cttgggtgcc tgaggcagga gaatctctta   2280

aaccaggaag gcagagattg cagtgagctg agataatccc actgcattcc agcctgggca   2340

acagcgtgag acttcatctc aaaaaaaaaa aattgtattt gtacttttaa agggattttg   2400

cagtatgttg tagttaaacg ttaataaaat tatatttgta attaggaaaa aaaaaaaaaa   2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2507


<210>  826
<211>  573
<212>  PRT
<213>  Homosapiens

<400>  826

Met Thr Pro Glu Ser Arg Asp Thr Thr Asp Leu Ser Pro Gly Gly Thr 
1               5                   10                  15      


Gln Glu Met Glu Gly Ile Val Ile Val Lys Val Glu Glu Glu Asp Glu 
            20                  25                  30          


Glu Asp His Phe Gln Lys Glu Arg Asn Lys Val Glu Ser Ser Pro Gln 
        35                  40                  45              


Val Leu Ser Arg Ser Thr Thr Met Asn Glu Arg Ala Leu Leu Ser Ser 
    50                  55                  60                  


Tyr Leu Val Ala Tyr Arg Val Ala Lys Glu Lys Met Ala His Thr Ala 
65                  70                  75                  80  


Ala Glu Lys Ile Ile Leu Pro Ala Cys Met Asp Met Val Arg Thr Ile 
                85                  90                  95      


Phe Asp Asp Lys Ser Ala Asp Lys Leu Arg Thr Ile Pro Leu Ser Asp 
            100                 105                 110         


Asn Thr Ile Ser Arg Arg Ile Cys Thr Ile Ala Lys His Leu Glu Ala 
        115                 120                 125             


Met Leu Ile Thr Arg Leu Gln Ser Gly Ile Asp Phe Ala Ile Gln Leu 
    130                 135                 140                 


Asp Glu Ser Thr Asp Ile Ala Ser Cys Pro Thr Leu Leu Val Tyr Val 
145                 150                 155                 160 


Arg Tyr Val Trp Gln Asp Asp Phe Val Glu Asp Leu Leu Cys Cys Leu 
                165                 170                 175     


Asn Leu Asn Ser His Ile Thr Gly Leu Asp Leu Phe Thr Glu Leu Glu 
            180                 185                 190         


Asn Cys Leu Leu Gly Gln Tyr Lys Leu Asn Trp Lys His Cys Lys Gly 
        195                 200                 205             


Ile Ser Ser Asp Gly Thr Ala Asn Met Thr Gly Lys His Ser Arg Leu 
    210                 215                 220                 


Thr Glu Lys Leu Leu Glu Ala Thr His Asn Asn Ala Val Trp Asn His 
225                 230                 235                 240 


Cys Phe Ile His Arg Glu Ala Leu Val Ser Lys Glu Ile Ser Pro Ser 
                245                 250                 255     


Leu Met Asp Val Leu Lys Asn Ala Val Lys Thr Val Asn Phe Ile Lys 
            260                 265                 270         


Gly Ser Ser Leu Asn Ser Arg Leu Leu Glu Ile Phe Cys Ser Glu Ile 
        275                 280                 285             


Gly Val Asn His Thr His Leu Leu Phe His Thr Glu Val Arg Trp Leu 
    290                 295                 300                 


Ser Gln Gly Lys Val Leu Ser Arg Val Tyr Glu Leu Arg Asn Glu Ile 
305                 310                 315                 320 


Tyr Ile Phe Leu Val Glu Lys Gln Ser His Leu Ala Asn Ile Phe Glu 
                325                 330                 335     


Asp Asp Ile Trp Val Thr Lys Leu Ala Tyr Leu Ser Asp Ile Phe Gly 
            340                 345                 350         


Ile Leu Asn Glu Leu Ser Leu Lys Met Gln Gly Lys Asn Asn Asp Ile 
        355                 360                 365             


Phe Gln Tyr Leu Glu His Ile Leu Gly Phe Gln Lys Thr Leu Leu Leu 
    370                 375                 380                 


Trp Gln Ala Arg Leu Lys Ser Asn Arg Pro Ser Tyr Tyr Met Phe Pro 
385                 390                 395                 400 


Thr Leu Leu Gln His Ile Glu Glu Asn Ile Ile Asn Glu Asp Cys Leu 
                405                 410                 415     


Lys Glu Ile Lys Leu Glu Ile Leu Leu His Leu Thr Ser Leu Ser Gln 
            420                 425                 430         


Thr Phe Asn Tyr Tyr Phe Pro Glu Glu Lys Phe Glu Ser Leu Lys Glu 
        435                 440                 445             


Asn Ile Trp Met Lys Asp Pro Phe Ala Phe Gln Asn Pro Glu Ser Ile 
    450                 455                 460                 


Ile Glu Leu Asn Leu Glu Pro Glu Glu Glu Asn Glu Leu Leu Gln Leu 
465                 470                 475                 480 


Ser Ser Ser Phe Thr Leu Lys Asn Tyr Tyr Lys Ile Leu Ser Leu Ser 
                485                 490                 495     


Ala Phe Trp Ile Lys Ile Lys Asp Asp Phe Pro Leu Leu Ser Arg Lys 
            500                 505                 510         


Ser Ile Leu Leu Leu Leu Pro Phe Thr Thr Thr Tyr Leu Cys Glu Leu 
        515                 520                 525             


Gly Phe Ser Ile Leu Thr Arg Leu Lys Thr Lys Lys Arg Asn Arg Leu 
    530                 535                 540                 


Asn Ser Ala Pro Asp Met Arg Val Ala Leu Ser Ser Cys Val Pro Asp 
545                 550                 555                 560 


Trp Lys Glu Leu Met Asn Arg Gln Ala His Pro Ser His 
                565                 570             


<210>  827
<211>  4983
<212>  DNA
<213>  Homosapiens

<400>  827
cagtgagtta gcatggaggg cagtgggacc ggaaaaagac gtggaaaagc tgcgaaaacg     60

agccttcgaa tcatggacgc gcgggcccag ctcctcctcc gagttcctca tccggggccg    120

tcactcacat ccggggccct cactcacatc cgggaccctc atccggggct ctcacccaca    180

tccgggaccc tcatgcctgg gcggaggagg gggggccctc attcgggacc ctgcactccg    240

tcgccggaag tgccaccgag aagcgccggc ctcggggctg tctacagcgg cccgggagag    300

gctgtggtgg ccccgagcgc gagtgtgtag gtgacaggac agcggccagg cccgcccctc    360

ccctcgtgat ggtcattgtc ctccagagca gtgatggagg aaataccagc ccaggaagca    420

gcagggtcac caagggtcca gtttcagtct ttggagaccc agtctgagtg tctgtcccca    480

gagcctcagt ttgtgcagga caccgacatg gaacagggac tcactggggg ttagctaacc    540

atgcagcagg tgcttgagtt tcacctttct ccagtccagc agaattacat tttgatgacc    600

tccattttga tacttgtaga ccagatctaa tccgaagatt aatctttagg atttccaatt    660

tccaagcctg atgggatctc ccagctggaa caggatctac aggtctttga tctggaaact    720

aagactagag aagtcttaag agatgactgc tcagatggag agaccagaga agagaacaag    780

ctgttgattc ctaagcagaa aatttcggaa gaagtgcatt catacaaagt gagagtagga    840

agactcaaac acgatattac ccaagttcct gagactagag aagtgtataa gtctgaggac    900

agattagaaa gacttcagga aattctaagg aaatttctgt acctggagag agagtttagg    960

caaataacaa tcagcaagga aaccttcacc agtgagaaga acaatgaatg tcatgaaccc   1020

gaaaaaagct tcagtctgga ctctactatt gatgcagatc agagagttct tagaatacag   1080

aataccgatg acaatgataa gtatgacatg agcttcaacc agaattcagc ctctggtaaa   1140

catgaacact taaatctaac agaggatttt cagagtagtg aatgtaagga aagcttaatg   1200

gatctctccc accttaataa atgggagagc atccctaaca ctgagaaatc ctataaatgt   1260

gatgtatgtg ggaaaatttt ccatcagagc tcagccctta ctagacatca gagaatccat   1320

actagagaga agccctacaa atgtaaagaa tgtgaaaagt ctttcagtca gagctcaagt   1380

cttagtcgac ataaaagaat acacactaga gaaaaacctt acaaatgtga agcatctgat   1440

aaatcctgtg aagcgtctga taaatcctgt agtccaagct caggcataat tcagcataag   1500

aaaattcaca ccagagccaa atcttacaaa tgtagcagtt gtgaaagagt cttcagtcgt   1560

agtgtccacc ttactcaaca tcagaaaatt cacaaagaga tgccctgtaa gtgtactgta   1620

tgtggcagtg acttctgcca tacttcatac ctacttgaac atcagagggt ccatcatgaa   1680

gagaaagcct atgagtatga tgaatatggg ttggcctata ttaaacaaca aggaattcat   1740

ttcagagaaa agccctatac gtgtagtgaa tgtggaaaag acttcagatt gaattcacat   1800

cttattcagc atcaaagaat tcacacagga gagaaagcac atgaatgtaa tgaatgtgga   1860

aaagctttca gtcaaacctc atgccttatt cagcatcaca aaatgcatag gaaagagaaa   1920

tcgtatgaat gtaatgagta tgagggcagt ttcagtcata gctcagatct tatcctgcaa   1980

caagaagtcc tcaccagaca gaaagccttt gattgtgatg tatgggaaaa gaactccagt   2040

cagagagcac atctagttca acatcagagc attcatacca aagagaactc atgaatgtaa   2100

tgaagatggg aagatattta tcaaattcag gcttcattca gcatctgaga gttcacacca   2160

gggagaaatc atgtatgtac tgcatgtggt aaagccttca gtcatagctc agccattgct   2220

cagcatcaga taattcacac cagagagaaa ccctctgaat gtgacgaatg aagaaaaggt   2280

attagtgtta aactcttaat cgactcctgc aaatctatac cagtgagaaa tcttacaaat   2340

gtattgaatg tggcaaattt ttcatgctat tagtattttc ataccttagt cacatttgga   2400

gaattcacat gggaataaaa ttccattgct gcaatgaatg tgaaaaagcc atcagtcaaa   2460

gaaactacct tgtttagtat caaattcacg ccatgcaaaa agattataaa tgtaataagc   2520

atgtatgtgt gtgaggagat tcagtcataa cccaacgctc attcaacatc aaagaattta   2580

tacctaagag aacttatttg ggtgtagtaa atggcagatc tttcaatagg agtttaacta   2640

gtctttgtca tatcagaata tccatagtag acaagaattt gatgtaacgc aaatggaaaa   2700

actcgacacc acatttcagg ctttacccaa catcgaaata atggagagaa aattgttgat   2760

tatttgttta tgaaattgtt aatacatagt cccaatcttt ttcattgcac aaaaatctag   2820

ggttgacttg gtaaatgcag tgacattttc tcatggagtt cctttattta atatgtattc   2880

taagtaggta cgtttatttt tactttttta ttataatttt gatattaaaa agaacagaga   2940

tggggtcttg ctttgttgcc caggctggtc ttgaactcct ggcctcaagc gatcctccca   3000

cctgtcctcc caaagtgctg gggttacagg cgtgtgtcac tgtgctgggc ctattttatt   3060

tatagaactc atttaagctg tttttatttt aatatgccct ataaacattt ttatattttt   3120

tgaaattggt tcttagtgtt cacaacttcc ataagatact gctaatgcac cagtattaaa   3180

acacatcgac gtaagtagct catttagctt tttctgctgt tcttggccca agttctttcc   3240

aaaaccaact cttaggcctg ctctttacta gggatcttat gtcgtattgc tttacagcca   3300

caacacttgg attcctgttg attaacttct ccattctctt aagcaccttt agaagattta   3360

gaagtttcct agttttaagt gtttcaccag caagtattcc atacctactt gatgttgctg   3420

gtctggtgtc ttatttccta aagtgaagca tcttttttta aaaaagaatt tgattgacaa   3480

tatatccagt ccaatataag tatgaaggat tctctctcct gagattgtag caggcagcca   3540

aacattttca aatgatgccc aaggttttag ctgtcttgtg tgcatccaca gtctgcgaag   3600

aagacatgat aaggacatca gggagccaac aagactccta atagcctcac tacattcatc   3660

cagtgcctat tctgcatgcc taagcttaga gttcttttat atacctctac ggccagcaaa   3720

atgctcaggt ctgctcttgg tagggtaaac ataaagaaga tacacaggcc gggcatggtg   3780

gctcacacct gtaatcccag cactttggga ggctgaggcg gatggatcac gaggtcaggc   3840

agtcgagacc atcctggcca acatggtgaa accccgtctc tactaaaaat acaaaagtta   3900

gccgggtgtg gtggcacgcg cctgtaatcc cagctactca ggaggctgag gcaggagaac   3960

tgcttgaacc tgggaggcgg aggttgcagt gagccgagat tgcaccactg cactccagcc   4020

tgggcgacag agcaggactc tctctcaaaa aaacacaaaa aaacaaaaac aaaaaaccat   4080

acacacacac acacacacac aaatcagcat cataagggaa tgtagccttc caacagagat   4140

gatgctgttc gtatgttaat ctcagagaca gtatttcaag agagtggcag gtctgttcct   4200

ggtaaaattt taaccattag gattgcagat aaatgtttga attctgctcc tctctcatca   4260

atccaggaca gtatttgaag tgtgagggct ttgtgtatag ttgtttatcc attaccacat   4320

ttttgtattt taatagtcta caggctatat aaaagaacat ggctttttga ctgataaaag   4380

tgattacaga tgttggctca agttcagggc caccatcata tacctaacaa gagttcatga   4440

ttctttaggt aatgtcaaaa cattttgtat ttttccatct taagctttat aacattttgt   4500

gagtaagaca aatgttattt aaaattcttg ttgtcagtcc agcaattgag gctttcatag   4560

ttcagtgtta taatattcag tagggaccct caacaaatat ataaaaatat gttgctcact   4620

ctataatcct cctatggcta acctctagga tagttctgcc actatatttt acttctttgc   4680

catcagcaag agtaggattt catcaaggca aggtaggaat ctaaatgaaa ttgatatata   4740

aatgaattga tctaaatgta aaagcaaatg aaaaatgcat gtgttttttc ctgtcaaaca   4800

tgtataccct tatgtataga gaccagtagt cacgtatggt gactgaaaca ggattatgta   4860

atccctaaaa agcagaatat gtaaaaatca catgtatgcg tttggtttag gaatgtgctt   4920

ttgtacttcc acttgaataa aggtgtgttt ggtattctga gaaaaaaaaa aaaaaaaaaa   4980

aaa                                                                 4983


<210>  828
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  828

Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly 
        35                  40                  45      


<210>  829
<211>  2002
<212>  DNA
<213>  Homosapiens

<400>  829
cagtgagtta gcatggaggg cagtgggacc ggaaaaagac gtggaaaagc tgcgaaaacg     60

agccttcgaa tcatggacgc gcgggcccag ctcctcctcc gagttcctca tccggggccg    120

tcactcacat ccggggccct cactcacatc cgggaccctc atccggggct ctcacccaca    180

tccgggaccc tcatgcctgg gcggaggagg gggggccctc attcgggacc ctgcactccg    240

tcgccggaag tgccaccgag aagcgccggc ctcggggctg tctacagcgg cccgggagag    300

gctgtggtgg ccccgagcgc gagtgtgtag gtgacaggac agcggccagg cccgcccctc    360

ccctcgtgat ggtcattgtc ctccagagca gtgatggagg aaataccagc ccaggaagca    420

gcagggtcac caagggtcca gtttcagtct ttggagaccc agtctgagtg tctgtcccca    480

gagcctcagt ttgtgcagga caccgacatg gaacagggac tcactggggc tccacctgtt    540

cctcaggtgc ctgctcttcc ccgtgaggga agcccaggag accaggcagc tgcgctcttg    600

acagccaggt accaggtgag ctgaggaacc ctctgctttt cctcagggac tattgctact    660

gatggagtgt ggcctctctc tcatcccatc tgtagacctt gcctggaatt tttttcaata    720

gcagactcca gtttgggaat tgatcctctt cggagacctg gacttcacat aaaccaactt    780

cccatctccc cagtgccatg agcaaactct gttttctctt tgtccatggt tgtgtgatgg    840

gtgcttatta gatgtttaag ggttatgggc tttattccgt aggttctaat ctgttctccc    900

tcctcctcaa cgtaagtaca cagtggatac cctctctatg atcttcattc tctggccatg    960

gtgctacagt gttctcattc ctcagagcag ccaggatgtg ttatttcagg agtttgtgac   1020

attcgaggat gtggctgtgc accttactcg agaggaatgg ggatacctgg accctgttca   1080

gagggacctc tacagagaag tgatgttaga gaattatggg aacgtggtct cactgggcat   1140

acttctccgc cttcccacca cccggattca tagtgtgaat tcctgcccgg ccctgagtca   1200

tacccaggca agtgctttct ctggagaaac acttgccgtc cttacagcag gaatctccaa   1260

gagatggccc aagtatcggc ttcccatcga tattgctcgt ccctgctcgg aaactccttt   1320

tccacgattg tgagatatta aaattgactg atggaataga agctccccag gatgccacca   1380

ctgtgtaaaa tcgcagctcc tcaaattacc tctgtttaat ttcaaatgtt agggtccaag   1440

gaagccctct gttgcaacca gatatgtttt gaacccagtt cattcagaaa ccatggttgg   1500

tggtcatcat ctacttgtat tgtgaaaaac cagaaattcc aaattcagct cttcagttat   1560

ggtcttttca tattatttta gaatgtgaaa cttatgctgt gtgcccctcc ttttatgtgg   1620

cgaacacaac ctgccccgta tggtgcctaa ctctcctgtg aaccctgggc ttccctcatg   1680

tttaacattc tggtttcctc cttccttgaa gtccctgtgg ccctcttcaa ggtcctacct   1740

tcctaccctt tattctttgt ggttctgtac agattgatgc aattatattg cctttcctga   1800

ttaagtgttc cttactctgt ccttgatgga ggggagaagg gagggcaaag aagttaaatt   1860

tatttcaggg catcaaattg aatatctact taataacttt gtaaactgta aagtgacata   1920

catataattg taaagtactg ttaattttat ctaataatta cagagtttcc aacagttaaa   1980

aaaaaaaaaa aaaaaaaaaa aa                                            2002


<210>  830
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  830

Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Ala Pro Pro 
        35                  40                  45              


Val Pro Gln Val Pro Ala Leu Pro Arg Glu Gly Ser Pro Gly Asp Gln 
    50                  55                  60                  


Ala Ala Ala Leu Leu Thr Ala Arg Tyr Gln Val Ser 
65                  70                  75      


<210>  831
<211>  1222
<212>  DNA
<213>  Homosapiens

<400>  831
tggcagcttg ttttgccttc acgggagtag aaggaggcgg cgtccggccg cggccgacgg     60

tagttcgctt ccccgagagt gcgcggaggc ccgggtgcga ggagggcctg tttctcttca    120

gccctggttc attcacctcg cggaccgagg gccccgccgt caggagccgg cgaccgtgcc    180

ctggtgcgag ctgtgatggt cattgtcctc cagagcagtg atggaggaaa taccagccca    240

ggaagcagca gggtcaccaa gggtccagtt tcagtctttg gagacccagt ctgagtgtct    300

gtccccagag cctcagtttg tgcaggacac cgacatggaa cagggactca ctgggggcat    360

acttctccgc cttcccacca cccggattca tagtgtgaat tcctgcccgg ccctgagtca    420

tacccaggca agtgctttct ctggagaaac acttgccgtc cttacagcag gaatctccaa    480

gagatggccc aagtatcggc ttcccatcga tattgctcgt ccctgctcgg aaactccttt    540

tccacgattg tgagatatta aaattgactg atggaataga agctccccag gatgccacca    600

ctgtgtaaaa tcgcagctcc tcaaattacc tctgtttaat ttcaaatgtt agggtccaag    660

gaagccctct gttgcaacca gatatgtttt gaacccagtt cattcagaaa ccatggttgg    720

tggtcatcat ctacttgtat tgtgaaaaac cagaaattcc aaattcagct cttcagttat    780

ggtcttttca tattatttta gaatgtgaaa cttatgctgt gtgcccctcc ttttatgtgg    840

cgaacacaac ctgccccgta tggtgcctaa ctctcctgtg aaccctgggc ttccctcatg    900

tttaacattc tggtttcctc cttccttgaa gtccctgtgg ccctcttcaa ggtcctacct    960

tcctaccctt tattctttgt ggttctgtac agattgatgc aattatattg cctttcctga   1020

ttaagtgttc cttactctgt ccttgatgga ggggagaagg gagggcaaag aagttaaatt   1080

tatttcaggg catcaaattg aatatctact taataacttt gtaaactgta aagtgacata   1140

catataattg taaagtactg ttaattttat ctaataatta cagagtttcc aacagttaaa   1200

aaaaaaaaaa aaaaaaaaaa aa                                            1222


<210>  832
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  832

Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Gly Ile Leu 
        35                  40                  45              


Leu Arg Leu Pro Thr Thr Arg Ile His Ser Val Asn Ser Cys Pro Ala 
    50                  55                  60                  


Leu Ser His Thr Gln Ala Ser Ala Phe Ser Gly Glu Thr Leu Ala Val 
65                  70                  75                  80  


Leu Thr Ala Gly Ile Ser Lys Arg Trp Pro Lys Tyr Arg Leu Pro Ile 
                85                  90                  95      


Asp Ile Ala Arg Pro Cys Ser Glu Thr Pro Phe Pro Arg Leu 
            100                 105                 110 


<210>  833
<211>  4585
<212>  DNA
<213>  Homosapiens

<400>  833
tggcagcttg ttttgccttc acgggagtag aaggaggcgg cgtccggccg cggccgacgg     60

tagttcgctt ccccgagagt gcgcggaggc ccgggtgcga ggagggcctg tttctcttca    120

gccctggttc attcacctcg cggaccgagg gccccgccgt caggagccgg cgaccgtgcc    180

ctggtgcgag ctgtgatggt cattgtcctc cagagcagtg atggaggaaa taccagccca    240

ggaagcagca gggtcaccaa gggtccagtt tcagtctttg gagacccagt ctgagtgtct    300

gtccccagag cctcagtttg tgcaggacac cgacatggaa cagggactca ctggggatgg    360

agagaccaga gaagagaaca agctgttgat tcctaagcag aaaatttcgg aagaagtgca    420

ttcatacaaa gtgagagtag gaagactcaa acacgatatt acccaagttc ctgagactag    480

agaagtgtat aagtctgagg acagattaga aagacttcag gaaattctaa ggaaatttct    540

gtacctggag agagagttta ggcaaataac aatcagcaag gaaaccttca ccagtgagaa    600

gaacaatgaa tgtcatgaac ccgaaaaaag cttcagtctg gactctacta ttgatgcaga    660

tcagagagtt cttagaatac agaataccga tgacaatgat aagtatgaca tgagcttcaa    720

ccagaattca gcctctggta aacatgaaca cttaaatcta acagaggatt ttcagagtag    780

tgaatgtaag gaaagcttaa tggatctctc ccaccttaat aaatgggaga gcatccctaa    840

cactgagaaa tcctataaat gtgatgtatg tgggaaaatt ttccatcaga gctcagccct    900

tactagacat cagagaatcc atactagaga gaagccctac aaatgtaaag aatgtgaaaa    960

gtctttcagt cagagctcaa gtcttagtcg acataaaaga atacacacta gagaaaaacc   1020

ttacaaatgt gaagcatctg ataaatcctg tgaagcgtct gataaatcct gtagtccaag   1080

ctcaggcata attcagcata agaaaattca caccagagcc aaatcttaca aatgtagcag   1140

ttgtgaaaga gtcttcagtc gtagtgtcca ccttactcaa catcagaaaa ttcacaaaga   1200

gatgccctgt aagtgtactg tatgtggcag tgacttctgc catacttcat acctacttga   1260

acatcagagg gtccatcatg aagagaaagc ctatgagtat gatgaatatg ggttggccta   1320

tattaaacaa caaggaattc atttcagaga aaagccctat acgtgtagtg aatgtggaaa   1380

agacttcaga ttgaattcac atcttattca gcatcaaaga attcacacag gagagaaagc   1440

acatgaatgt aatgaatgtg gaaaagcttt cagtcaaacc tcatgcctta ttcagcatca   1500

caaaatgcat aggaaagaga aatcgtatga atgtaatgag tatgagggca gtttcagtca   1560

tagctcagat cttatcctgc aacaagaagt cctcaccaga cagaaagcct ttgattgtga   1620

tgtatgggaa aagaactcca gtcagagagc acatctagtt caacatcaga gcattcatac   1680

caaagagaac tcatgaatgt aatgaagatg ggaagatatt tatcaaattc aggcttcatt   1740

cagcatctga gagttcacac cagggagaaa tcatgtatgt actgcatgtg gtaaagcctt   1800

cagtcatagc tcagccattg ctcagcatca gataattcac accagagaga aaccctctga   1860

atgtgacgaa tgaagaaaag gtattagtgt taaactctta atcgactcct gcaaatctat   1920

accagtgaga aatcttacaa atgtattgaa tgtggcaaat ttttcatgct attagtattt   1980

tcatacctta gtcacatttg gagaattcac atgggaataa aattccattg ctgcaatgaa   2040

tgtgaaaaag ccatcagtca aagaaactac cttgtttagt atcaaattca cgccatgcaa   2100

aaagattata aatgtaataa gcatgtatgt gtgtgaggag attcagtcat aacccaacgc   2160

tcattcaaca tcaaagaatt tatacctaag agaacttatt tgggtgtagt aaatggcaga   2220

tctttcaata ggagtttaac tagtctttgt catatcagaa tatccatagt agacaagaat   2280

ttgatgtaac gcaaatggaa aaactcgaca ccacatttca ggctttaccc aacatcgaaa   2340

taatggagag aaaattgttg attatttgtt tatgaaattg ttaatacata gtcccaatct   2400

ttttcattgc acaaaaatct agggttgact tggtaaatgc agtgacattt tctcatggag   2460

ttcctttatt taatatgtat tctaagtagg tacgtttatt tttacttttt tattataatt   2520

ttgatattaa aaagaacaga gatggggtct tgctttgttg cccaggctgg tcttgaactc   2580

ctggcctcaa gcgatcctcc cacctgtcct cccaaagtgc tggggttaca ggcgtgtgtc   2640

actgtgctgg gcctatttta tttatagaac tcatttaagc tgtttttatt ttaatatgcc   2700

ctataaacat ttttatattt tttgaaattg gttcttagtg ttcacaactt ccataagata   2760

ctgctaatgc accagtatta aaacacatcg acgtaagtag ctcatttagc tttttctgct   2820

gttcttggcc caagttcttt ccaaaaccaa ctcttaggcc tgctctttac tagggatctt   2880

atgtcgtatt gctttacagc cacaacactt ggattcctgt tgattaactt ctccattctc   2940

ttaagcacct ttagaagatt tagaagtttc ctagttttaa gtgtttcacc agcaagtatt   3000

ccatacctac ttgatgttgc tggtctggtg tcttatttcc taaagtgaag catctttttt   3060

taaaaaagaa tttgattgac aatatatcca gtccaatata agtatgaagg attctctctc   3120

ctgagattgt agcaggcagc caaacatttt caaatgatgc ccaaggtttt agctgtcttg   3180

tgtgcatcca cagtctgcga agaagacatg ataaggacat cagggagcca acaagactcc   3240

taatagcctc actacattca tccagtgcct attctgcatg cctaagctta gagttctttt   3300

atatacctct acggccagca aaatgctcag gtctgctctt ggtagggtaa acataaagaa   3360

gatacacagg ccgggcatgg tggctcacac ctgtaatccc agcactttgg gaggctgagg   3420

cggatggatc acgaggtcag gcagtcgaga ccatcctggc caacatggtg aaaccccgtc   3480

tctactaaaa atacaaaagt tagccgggtg tggtggcacg cgcctgtaat cccagctact   3540

caggaggctg aggcaggaga actgcttgaa cctgggaggc ggaggttgca gtgagccgag   3600

attgcaccac tgcactccag cctgggcgac agagcaggac tctctctcaa aaaaacacaa   3660

aaaaacaaaa acaaaaaacc atacacacac acacacacac acaaatcagc atcataaggg   3720

aatgtagcct tccaacagag atgatgctgt tcgtatgtta atctcagaga cagtatttca   3780

agagagtggc aggtctgttc ctggtaaaat tttaaccatt aggattgcag ataaatgttt   3840

gaattctgct cctctctcat caatccagga cagtatttga agtgtgaggg ctttgtgtat   3900

agttgtttat ccattaccac atttttgtat tttaatagtc tacaggctat ataaaagaac   3960

atggcttttt gactgataaa agtgattaca gatgttggct caagttcagg gccaccatca   4020

tatacctaac aagagttcat gattctttag gtaatgtcaa aacattttgt atttttccat   4080

cttaagcttt ataacatttt gtgagtaaga caaatgttat ttaaaattct tgttgtcagt   4140

ccagcaattg aggctttcat agttcagtgt tataatattc agtagggacc ctcaacaaat   4200

atataaaaat atgttgctca ctctataatc ctcctatggc taacctctag gatagttctg   4260

ccactatatt ttacttcttt gccatcagca agagtaggat ttcatcaagg caaggtagga   4320

atctaaatga aattgatata taaatgaatt gatctaaatg taaaagcaaa tgaaaaatgc   4380

atgtgttttt tcctgtcaaa catgtatacc cttatgtata gagaccagta gtcacgtatg   4440

gtgactgaaa caggattatg taatccctaa aaagcagaat atgtaaaaat cacatgtatg   4500

cgtttggttt aggaatgtgc ttttgtactt ccacttgaat aaaggtgtgt ttggtattct   4560

gagaaaaaaa aaaaaaaaaa aaaaa                                         4585


<210>  834
<211>  491
<212>  PRT
<213>  Homosapiens

<400>  834

Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Asp Gly Glu 
        35                  40                  45              


Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys Ile Ser Glu 
    50                  55                  60                  


Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys His Asp Ile 
65                  70                  75                  80  


Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu Asp Arg Leu 
                85                  90                  95      


Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu Glu Arg Glu 
            100                 105                 110         


Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser Glu Lys Asn 
        115                 120                 125             


Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr Ile 
    130                 135                 140                 


Asp Ala Asp Gln Arg Val Leu Arg Ile Gln Asn Thr Asp Asp Asn Asp 
145                 150                 155                 160 


Lys Tyr Asp Met Ser Phe Asn Gln Asn Ser Ala Ser Gly Lys His Glu 
                165                 170                 175     


His Leu Asn Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys Lys Glu Ser 
            180                 185                 190         


Leu Met Asp Leu Ser His Leu Asn Lys Trp Glu Ser Ile Pro Asn Thr 
        195                 200                 205             


Glu Lys Ser Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe His Gln Ser 
    210                 215                 220                 


Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr 
225                 230                 235                 240 


Lys Cys Lys Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser Ser Leu Ser 
                245                 250                 255     


Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Ala 
            260                 265                 270         


Ser Asp Lys Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser Pro Ser Ser 
        275                 280                 285             


Gly Ile Ile Gln His Lys Lys Ile His Thr Arg Ala Lys Ser Tyr Lys 
    290                 295                 300                 


Cys Ser Ser Cys Glu Arg Val Phe Ser Arg Ser Val His Leu Thr Gln 
305                 310                 315                 320 


His Gln Lys Ile His Lys Glu Met Pro Cys Lys Cys Thr Val Cys Gly 
                325                 330                 335     


Ser Asp Phe Cys His Thr Ser Tyr Leu Leu Glu His Gln Arg Val His 
            340                 345                 350         


His Glu Glu Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu Ala Tyr Ile 
        355                 360                 365             


Lys Gln Gln Gly Ile His Phe Arg Glu Lys Pro Tyr Thr Cys Ser Glu 
    370                 375                 380                 


Cys Gly Lys Asp Phe Arg Leu Asn Ser His Leu Ile Gln His Gln Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Ala His Glu Cys Asn Glu Cys Gly Lys Ala 
                405                 410                 415     


Phe Ser Gln Thr Ser Cys Leu Ile Gln His His Lys Met His Arg Lys 
            420                 425                 430         


Glu Lys Ser Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe Ser His Ser 
        435                 440                 445             


Ser Asp Leu Ile Leu Gln Gln Glu Val Leu Thr Arg Gln Lys Ala Phe 
    450                 455                 460                 


Asp Cys Asp Val Trp Glu Lys Asn Ser Ser Gln Arg Ala His Leu Val 
465                 470                 475                 480 


Gln His Gln Ser Ile His Thr Lys Glu Asn Ser 
                485                 490     


<210>  835
<211>  1608
<212>  DNA
<213>  Homosapiens

<400>  835
cagtgagtta gcatggaggg cagtgggacc ggaaaaagac gtggaaaagc tgcgaaaacg     60

agccttcgaa tcatggacgc gcgggcccag ctcctcctcc gagttcctca tccggggccg    120

tcactcacat ccggggccct cactcacatc cgggaccctc atccggggct ctcacccaca    180

tccgggaccc tcatgcctgg gcggaggagg gggggccctc attcgggacc ctgcactccg    240

tcgccggaag tgccaccgag aagcgccggc ctcggggctg tctacagcgg cccgggagag    300

gctgtggtgg ccccgagcgc gagtgtgtag gtgacaggac agcggccagg cccgcccctc    360

ccctcgtgat ggtcattgtc ctccagagca gtgatggagg aaataccagc ccaggaagca    420

gcagggtcac caagggtcca gtttcagtct ttggagaccc agtctgagtg tctgtcccca    480

gagcctcagt ttgtgcagga caccgacatg gaacagggac tcactggggc tccacctgtt    540

cctcaggtgc ctgctcttcc ccgtgaggga agcccaggag accaggcagc tgcgctcttg    600

acagccaggt accaggagtt tgtgacattc gaggatgtgg ctgtgcacct tactcgagag    660

gaatggggat acctggaccc tgttcagagg gacctctaca gagaagtgat gttagagaat    720

tatgggaacg tggtctcact gggcatactt ctccgccttc ccaccacccg gattcatagt    780

gtgaattcct gcccggccct gagtcatacc caggcaagtg ctttctctgg agaaacactt    840

gccgtcctta cagcaggaat ctccaagaga tggcccaagt atcggcttcc catcgatatt    900

gctcgtccct gctcggaaac tccttttcca cgattgtgag atattaaaat tgactgatgg    960

aatagaagct ccccaggatg ccaccactgt gtaaaatcgc agctcctcaa attacctctg   1020

tttaatttca aatgttaggg tccaaggaag ccctctgttg caaccagata tgttttgaac   1080

ccagttcatt cagaaaccat ggttggtggt catcatctac ttgtattgtg aaaaaccaga   1140

aattccaaat tcagctcttc agttatggtc ttttcatatt attttagaat gtgaaactta   1200

tgctgtgtgc ccctcctttt atgtggcgaa cacaacctgc cccgtatggt gcctaactct   1260

cctgtgaacc ctgggcttcc ctcatgttta acattctggt ttcctccttc cttgaagtcc   1320

ctgtggccct cttcaaggtc ctaccttcct accctttatt ctttgtggtt ctgtacagat   1380

tgatgcaatt atattgcctt tcctgattaa gtgttcctta ctctgtcctt gatggagggg   1440

agaagggagg gcaaagaagt taaatttatt tcagggcatc aaattgaata tctacttaat   1500

aactttgtaa actgtaaagt gacatacata taattgtaaa gtactgttaa ttttatctaa   1560

taattacaga gtttccaaca gttaaaaaaa aaaaaaaaaa aaaaaaaa                1608


<210>  836
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  836

Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Ala Pro Pro 
        35                  40                  45              


Val Pro Gln Val Pro Ala Leu Pro Arg Glu Gly Ser Pro Gly Asp Gln 
    50                  55                  60                  


Ala Ala Ala Leu Leu Thr Ala Arg Tyr Gln Glu Phe Val Thr Phe Glu 
65                  70                  75                  80  


Asp Val Ala Val His Leu Thr Arg Glu Glu Trp Gly Tyr Leu Asp Pro 
                85                  90                  95      


Val Gln Arg Asp Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Gly Asn 
            100                 105                 110         


Val Val Ser Leu Gly Ile Leu Leu Arg Leu Pro Thr Thr Arg Ile His 
        115                 120                 125             


Ser Val Asn Ser Cys Pro Ala Leu Ser His Thr Gln Ala Ser Ala Phe 
    130                 135                 140                 


Ser Gly Glu Thr Leu Ala Val Leu Thr Ala Gly Ile Ser Lys Arg Trp 
145                 150                 155                 160 


Pro Lys Tyr Arg Leu Pro Ile Asp Ile Ala Arg Pro Cys Ser Glu Thr 
                165                 170                 175     


Pro Phe Pro Arg Leu 
            180     


<210>  837
<211>  4758
<212>  DNA
<213>  Homosapiens

<400>  837
cagtgagtta gcatggaggg cagtgggacc ggaaaaagac gtggaaaagc tgcgaaaacg     60

agccttcgaa tcatggacgc gcgggcccag ctcctcctcc gagttcctca tccggggccg    120

tcactcacat ccggggccct cactcacatc cgggaccctc atccggggct ctcacccaca    180

tccgggaccc tcatgcctgg gcggaggagg gggggccctc attcgggacc ctgcactccg    240

tcgccggaag tgccaccgag aagcgccggc ctcggggctg tctacagcgg cccgggagag    300

gctgtggtgg ccccgagcgc gagtgtgtag gtgacaggac agcggccagg cccgcccctc    360

ccctcgtgat ggtcattgtc ctccagagca gtgatggagg aaataccagc ccaggaagca    420

gcagggtcac caagggtcca gtttcagtct ttggagaccc agtctgagtg tctgtcccca    480

gagcctcagt ttgtgcagga caccgacatg gaacagggac tcactgggga tggagagacc    540

agagaagaga acaagctgtt gattcctaag cagaaaattt cggaagaagt gcattcatac    600

aaagtgagag taggaagact caaacacgat attacccaag ttcctgagac tagagaagtg    660

tataagtctg aggacagatt agaaagactt caggaaattc taaggaaatt tctgtacctg    720

gagagagagt ttaggcaaat aacaatcagc aaggaaacct tcaccagtga gaagaacaat    780

gaatgtcatg aacccgaaaa aagcttcagt ctggactcta ctattgatgc agatcagaga    840

gttcttagaa tacagaatac cgatgacaat gataagtatg acatgagctt caaccagaat    900

tcagcctctg gtaaacatga acacttaaat ctaacagagg attttcagag tagtgaatgt    960

aaggaaagct taatggatct ctcccacctt aataaatggg agagcatccc taacactgag   1020

aaatcctata aatgtgatgt atgtgggaaa attttccatc agagctcagc ccttactaga   1080

catcagagaa tccatactag agagaagccc tacaaatgta aagaatgtga aaagtctttc   1140

agtcagagct caagtcttag tcgacataaa agaatacaca ctagagaaaa accttacaaa   1200

tgtgaagcat ctgataaatc ctgtgaagcg tctgataaat cctgtagtcc aagctcaggc   1260

ataattcagc ataagaaaat tcacaccaga gccaaatctt acaaatgtag cagttgtgaa   1320

agagtcttca gtcgtagtgt ccaccttact caacatcaga aaattcacaa agagatgccc   1380

tgtaagtgta ctgtatgtgg cagtgacttc tgccatactt catacctact tgaacatcag   1440

agggtccatc atgaagagaa agcctatgag tatgatgaat atgggttggc ctatattaaa   1500

caacaaggaa ttcatttcag agaaaagccc tatacgtgta gtgaatgtgg aaaagacttc   1560

agattgaatt cacatcttat tcagcatcaa agaattcaca caggagagaa agcacatgaa   1620

tgtaatgaat gtggaaaagc tttcagtcaa acctcatgcc ttattcagca tcacaaaatg   1680

cataggaaag agaaatcgta tgaatgtaat gagtatgagg gcagtttcag tcatagctca   1740

gatcttatcc tgcaacaaga agtcctcacc agacagaaag cctttgattg tgatgtatgg   1800

gaaaagaact ccagtcagag agcacatcta gttcaacatc agagcattca taccaaagag   1860

aactcatgaa tgtaatgaag atgggaagat atttatcaaa ttcaggcttc attcagcatc   1920

tgagagttca caccagggag aaatcatgta tgtactgcat gtggtaaagc cttcagtcat   1980

agctcagcca ttgctcagca tcagataatt cacaccagag agaaaccctc tgaatgtgac   2040

gaatgaagaa aaggtattag tgttaaactc ttaatcgact cctgcaaatc tataccagtg   2100

agaaatctta caaatgtatt gaatgtggca aatttttcat gctattagta ttttcatacc   2160

ttagtcacat ttggagaatt cacatgggaa taaaattcca ttgctgcaat gaatgtgaaa   2220

aagccatcag tcaaagaaac taccttgttt agtatcaaat tcacgccatg caaaaagatt   2280

ataaatgtaa taagcatgta tgtgtgtgag gagattcagt cataacccaa cgctcattca   2340

acatcaaaga atttatacct aagagaactt atttgggtgt agtaaatggc agatctttca   2400

ataggagttt aactagtctt tgtcatatca gaatatccat agtagacaag aatttgatgt   2460

aacgcaaatg gaaaaactcg acaccacatt tcaggcttta cccaacatcg aaataatgga   2520

gagaaaattg ttgattattt gtttatgaaa ttgttaatac atagtcccaa tctttttcat   2580

tgcacaaaaa tctagggttg acttggtaaa tgcagtgaca ttttctcatg gagttccttt   2640

atttaatatg tattctaagt aggtacgttt atttttactt ttttattata attttgatat   2700

taaaaagaac agagatgggg tcttgctttg ttgcccaggc tggtcttgaa ctcctggcct   2760

caagcgatcc tcccacctgt cctcccaaag tgctggggtt acaggcgtgt gtcactgtgc   2820

tgggcctatt ttatttatag aactcattta agctgttttt attttaatat gccctataaa   2880

catttttata ttttttgaaa ttggttctta gtgttcacaa cttccataag atactgctaa   2940

tgcaccagta ttaaaacaca tcgacgtaag tagctcattt agctttttct gctgttcttg   3000

gcccaagttc tttccaaaac caactcttag gcctgctctt tactagggat cttatgtcgt   3060

attgctttac agccacaaca cttggattcc tgttgattaa cttctccatt ctcttaagca   3120

cctttagaag atttagaagt ttcctagttt taagtgtttc accagcaagt attccatacc   3180

tacttgatgt tgctggtctg gtgtcttatt tcctaaagtg aagcatcttt ttttaaaaaa   3240

gaatttgatt gacaatatat ccagtccaat ataagtatga aggattctct ctcctgagat   3300

tgtagcaggc agccaaacat tttcaaatga tgcccaaggt tttagctgtc ttgtgtgcat   3360

ccacagtctg cgaagaagac atgataagga catcagggag ccaacaagac tcctaatagc   3420

ctcactacat tcatccagtg cctattctgc atgcctaagc ttagagttct tttatatacc   3480

tctacggcca gcaaaatgct caggtctgct cttggtaggg taaacataaa gaagatacac   3540

aggccgggca tggtggctca cacctgtaat cccagcactt tgggaggctg aggcggatgg   3600

atcacgaggt caggcagtcg agaccatcct ggccaacatg gtgaaacccc gtctctacta   3660

aaaatacaaa agttagccgg gtgtggtggc acgcgcctgt aatcccagct actcaggagg   3720

ctgaggcagg agaactgctt gaacctggga ggcggaggtt gcagtgagcc gagattgcac   3780

cactgcactc cagcctgggc gacagagcag gactctctct caaaaaaaca caaaaaaaca   3840

aaaacaaaaa accatacaca cacacacaca cacacaaatc agcatcataa gggaatgtag   3900

ccttccaaca gagatgatgc tgttcgtatg ttaatctcag agacagtatt tcaagagagt   3960

ggcaggtctg ttcctggtaa aattttaacc attaggattg cagataaatg tttgaattct   4020

gctcctctct catcaatcca ggacagtatt tgaagtgtga gggctttgtg tatagttgtt   4080

tatccattac cacatttttg tattttaata gtctacaggc tatataaaag aacatggctt   4140

tttgactgat aaaagtgatt acagatgttg gctcaagttc agggccacca tcatatacct   4200

aacaagagtt catgattctt taggtaatgt caaaacattt tgtatttttc catcttaagc   4260

tttataacat tttgtgagta agacaaatgt tatttaaaat tcttgttgtc agtccagcaa   4320

ttgaggcttt catagttcag tgttataata ttcagtaggg accctcaaca aatatataaa   4380

aatatgttgc tcactctata atcctcctat ggctaacctc taggatagtt ctgccactat   4440

attttacttc tttgccatca gcaagagtag gatttcatca aggcaaggta ggaatctaaa   4500

tgaaattgat atataaatga attgatctaa atgtaaaagc aaatgaaaaa tgcatgtgtt   4560

ttttcctgtc aaacatgtat acccttatgt atagagacca gtagtcacgt atggtgactg   4620

aaacaggatt atgtaatccc taaaaagcag aatatgtaaa aatcacatgt atgcgtttgg   4680

tttaggaatg tgcttttgta cttccacttg aataaaggtg tgtttggtat tctgagaaaa   4740

aaaaaaaaaa aaaaaaaa                                                 4758


<210>  838
<211>  491
<212>  PRT
<213>  Homosapiens

<400>  838

Met Glu Glu Ile Pro Ala Gln Glu Ala Ala Gly Ser Pro Arg Val Gln 
1               5                   10                  15      


Phe Gln Ser Leu Glu Thr Gln Ser Glu Cys Leu Ser Pro Glu Pro Gln 
            20                  25                  30          


Phe Val Gln Asp Thr Asp Met Glu Gln Gly Leu Thr Gly Asp Gly Glu 
        35                  40                  45              


Thr Arg Glu Glu Asn Lys Leu Leu Ile Pro Lys Gln Lys Ile Ser Glu 
    50                  55                  60                  


Glu Val His Ser Tyr Lys Val Arg Val Gly Arg Leu Lys His Asp Ile 
65                  70                  75                  80  


Thr Gln Val Pro Glu Thr Arg Glu Val Tyr Lys Ser Glu Asp Arg Leu 
                85                  90                  95      


Glu Arg Leu Gln Glu Ile Leu Arg Lys Phe Leu Tyr Leu Glu Arg Glu 
            100                 105                 110         


Phe Arg Gln Ile Thr Ile Ser Lys Glu Thr Phe Thr Ser Glu Lys Asn 
        115                 120                 125             


Asn Glu Cys His Glu Pro Glu Lys Ser Phe Ser Leu Asp Ser Thr Ile 
    130                 135                 140                 


Asp Ala Asp Gln Arg Val Leu Arg Ile Gln Asn Thr Asp Asp Asn Asp 
145                 150                 155                 160 


Lys Tyr Asp Met Ser Phe Asn Gln Asn Ser Ala Ser Gly Lys His Glu 
                165                 170                 175     


His Leu Asn Leu Thr Glu Asp Phe Gln Ser Ser Glu Cys Lys Glu Ser 
            180                 185                 190         


Leu Met Asp Leu Ser His Leu Asn Lys Trp Glu Ser Ile Pro Asn Thr 
        195                 200                 205             


Glu Lys Ser Tyr Lys Cys Asp Val Cys Gly Lys Ile Phe His Gln Ser 
    210                 215                 220                 


Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr 
225                 230                 235                 240 


Lys Cys Lys Glu Cys Glu Lys Ser Phe Ser Gln Ser Ser Ser Leu Ser 
                245                 250                 255     


Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Ala 
            260                 265                 270         


Ser Asp Lys Ser Cys Glu Ala Ser Asp Lys Ser Cys Ser Pro Ser Ser 
        275                 280                 285             


Gly Ile Ile Gln His Lys Lys Ile His Thr Arg Ala Lys Ser Tyr Lys 
    290                 295                 300                 


Cys Ser Ser Cys Glu Arg Val Phe Ser Arg Ser Val His Leu Thr Gln 
305                 310                 315                 320 


His Gln Lys Ile His Lys Glu Met Pro Cys Lys Cys Thr Val Cys Gly 
                325                 330                 335     


Ser Asp Phe Cys His Thr Ser Tyr Leu Leu Glu His Gln Arg Val His 
            340                 345                 350         


His Glu Glu Lys Ala Tyr Glu Tyr Asp Glu Tyr Gly Leu Ala Tyr Ile 
        355                 360                 365             


Lys Gln Gln Gly Ile His Phe Arg Glu Lys Pro Tyr Thr Cys Ser Glu 
    370                 375                 380                 


Cys Gly Lys Asp Phe Arg Leu Asn Ser His Leu Ile Gln His Gln Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Ala His Glu Cys Asn Glu Cys Gly Lys Ala 
                405                 410                 415     


Phe Ser Gln Thr Ser Cys Leu Ile Gln His His Lys Met His Arg Lys 
            420                 425                 430         


Glu Lys Ser Tyr Glu Cys Asn Glu Tyr Glu Gly Ser Phe Ser His Ser 
        435                 440                 445             


Ser Asp Leu Ile Leu Gln Gln Glu Val Leu Thr Arg Gln Lys Ala Phe 
    450                 455                 460                 


Asp Cys Asp Val Trp Glu Lys Asn Ser Ser Gln Arg Ala His Leu Val 
465                 470                 475                 480 


Gln His Gln Ser Ile His Thr Lys Glu Asn Ser 
                485                 490     


<210>  839
<211>  4359
<212>  DNA
<213>  Homosapiens

<400>  839
agctcacttc cggaccgcgg atagcactgg cgaccctagc gggtgagagg cccttcaggg     60

ccgcggcggg ttgagcgcac catcacatct aagccatcag caagtttgtt ggttttaatc    120

tccaaaatac gtcttgattt tgtctgactc tttgccacca ccctgatcta agcccttatc    180

atctgcttga atcactaact tgtctccact tgcagttttt aaaagagttg cttccatttg    240

actttttctg tctgctgtac cagcatatga gtttcaggag gggtcattga tgcagtcatt    300

ctcagtctcc tcggagggag tctgaagatg cttaaagagc atccagagat ggcggaagct    360

cctcagcagc agttgggtat tcctgtggtg aaactggaga aagagttgcc atggggcaga    420

ggaagggagg accctagtcc agagactttt cggctgaggt ttcggcagtt ccgctaccag    480

gaggcagctg gaccccagga agctcttagg gagctccagg agctctgtcg tcggtggctg    540

aggcccgagt tgcacaccaa ggagcagatc ctggagctgc tggtgctgga gcagttcctc    600

actatcctgc cccgcgagtt ctacgcctgg atccgggagc atggcccaga gagtggcaag    660

gccctggccg ccatggtgga ggacctgaca gaaagagcac tggaggccaa ggcggttcca    720

tgccacaggc agggagagca ggaggaaaca gcactttgca gaggcgcttg ggagccaggc    780

atccagctgg ggccagtgga ggtcaagcct gaatggggga tgccccctgg ggaaggagtt    840

caaggtccag acccaggtac cgaggagcag ctcagtcagg accctggaga tgagacacgg    900

gccttccagg agcaagcact acctgttctg caggcgggtc ctggcctccc cgcagtgaat    960

cccagagacc aagagatggc agctgggttc tttactgctg gatcgcaggg gttggggcca   1020

tttaaagata tggccctggc cttccctgag gaggagtgga ggcatgtgac cccagcccag   1080

atagactgct ttggggagta tgtggaaccg caggactgca gggtctctcc aggcggtggg   1140

agcaaggaaa aggaggcaaa acccccacag gaagacctga aaggggcgct ggtggcactg   1200

acatcagaga ggtttgggga agcctctctc cagggccctg ggctcggaag ggtctgtgag   1260

caggagcctg gtggccctgc aggcagtgcg cctgggcttc ctcctcccca gcacggtgcc   1320

atccccctgc ctgacgaagt caaaacccac agctccttct ggaagccttt ccagtgccct   1380

gagtgtggga aaggattcag tcggagctcc aatctcgtca ggcaccagcg aacccacgaa   1440

gagaagtctt atggctgtgt ggagtgtggg aagggcttta ccctgagaga atacctgatg   1500

aagcaccaga gaacccacct gggaaagagg ccctacgtgt gcagcgagtg ctggaaaacc   1560

ttcagccaga gacaccacct ggaggtgcac cagcgcagcc acactgggga gaagccctac   1620

aagtgcgggg actgctggaa gagcttcagc cgcaggcagc acctgcaggt gcaccggagg   1680

acgcacaccg gggagaagcc ctacacctgc gagtgtggca agagcttcag caggaatgcc   1740

aatctggcgg tgcaccggcg tgcccacact ggcgagaagc catatgggtg ccaggtgtgc   1800

gggaagcggt tcagcaaagg ggagcggctg gtccgacacc agagaatcca tacaggggag   1860

aagccctacc actgtcctgc ctgcgggcga agcttcaacc agaggtccat cctcaaccgg   1920

caccagaaga cccagcaccg ccaggagccg ctggtgcagt gagcatagca ggtggcaggc   1980

agcaccatca ttcatctttc tcactgcagg gccttgcggg gtgcaaggtg atggctgcag   2040

gaaagcactg gtcccatcgc cttcccaccc attcgccaac gcgggaaagg caaggcctgg   2100

cttacttaga gcttccagag agcatagctg cttccatctc ttacccaagt ggtgctaaac   2160

aatttttctt ccaatgtttg agggaagcag tctcctgcgg ttcagttcag gctgagattt   2220

tctccttcag tggactgtct gtgtccccct gccgaacaaa gctgggagta aaggcaaaac   2280

cttgacacgt gttggtagct gggacctcat cttcctgagg gctctgtctt gcctgcaggg   2340

tcatagctca gactcttccc ccaccccctc tcttttccat tgaacaaaca tttattgaac   2400

atcctctgag cacctggccg tgggaatgcc gtggtgaatg agagactaga cgtgatgcct   2460

ctgggggttg tgcgttgggg atgcatgcga cagcccatga cccgaggcat tctcagggta   2520

tctgtgctgt gtgcccgtga gaacatcttc ccatgaccac tcctgccctc ctgccccgtg   2580

ctggatcttc cctccccagc tgggatctgc tcccaggcaa ctgtgtgaat tttacattat   2640

ttggagcctc atctgtgtca ggctataaca ttctatcctc atctgtaaaa cttccccgtc   2700

cattattcct tgcactataa caactgtcaa cacaccaact attaggaagt tagtattttg   2760

ctattgatca ctgaataaac atcagagtat tttaaaaaac agttctctag aaagaactgt   2820

tataattaaa atgagtctga aagatgaact ctagtattaa tgccctatat ttgatggcac   2880

tttatagttc ataaaattaa tttcacccca ttctcattgg acccatttcc caagtattta   2940

ttgaggccct gtaacaaaca tgtcaggaac tcttctgggt gcttgagaca catccatgaa   3000

taaaataggg ggagaagctg ttgacctcgt agagcttatg tctcgtggat gtacctgatc   3060

ttcagaaccc gtggatattc ctgcaaatcc tctgggcctg tattcattgc tttgtcagca   3120

tcttgccctg aaatgcattt gtcacctacc tcttgttact aaatggtctc tgccctccag   3180

acccttgtca tccaaggcac taggggtcct ggacacccac tggggatgat gagctggtag   3240

cgacctgttt tgcatgagtg ccaagtcagg aaaaataaag atatttgtag gcattaaaaa   3300

aaaatacatt tctttaaaaa tgagaagatg caatatttgt aaactgttga agcttcctta   3360

ttgtgccatc acttaagggt ttcatttctg tttaaagttc tggaagctgc ataactagcg   3420

tggactgact gctgtgtcat tgtgctgtgc ctttgaaccc tggctgagtg agtgagtttg   3480

tcctttgttg atagtgtcct ataattgcaa aatgtggttt gtcttctgat gcctcttaat   3540

accagattct tttactgaga tttttttttt tcattttcca ttgtaaataa ggtaaatggt   3600

aatgactaac acaaagctgt attactcagc ccactttgaa acgtggtttt atcacctgtt   3660

cttgttaggc agcatggtgt ctaattttgg cttagcaaat gacgctcctt ggtcttcctg   3720

gctcattagc tgtgcccacg aggctgcact gactgggtcg taaatgtatc tgagatgtcc   3780

acacggggct gctgctgctc ctctgtaata ctgaggtcca catgcaaaat cagctttttt   3840

tcccccgtaa ttatcagagc agctaggcag ggctgacagc caggcagact cagtgggagg   3900

cttctggcct gagtgtggcc ttccccagag ggtggttttc caaaggcagg tggggactgg   3960

ggaggcctcg gggggctgct tgtcattacc tgaatcacag atgctctttt gtcatacaca   4020

gccagcattc ctctgggttt cagcaagttg gcatatctta agcttcagaa ggagctgggc   4080

cttgctgact ttcctatctg gcctcttccc tatctcctgt ggggccaaga gcttaggaca   4140

gtgtctcaga aaagcctcta agtagggggt ttttcccatg ggattgtggt agtctgattt   4200

ttcatatcta ttcaaatgtt aagaaatatt ttgttttctg tatttttcta ttctttagaa   4260

atttttttat aatagataat ttcaaaccta tataaataaa tccttatgta tttatcattt   4320

gactttatta taaactcata atcaatctta aaaaaaaaa                          4359


<210>  840
<211>  544
<212>  PRT
<213>  Homosapiens

<400>  840

Met Leu Lys Glu His Pro Glu Met Ala Glu Ala Pro Gln Gln Gln Leu 
1               5                   10                  15      


Gly Ile Pro Val Val Lys Leu Glu Lys Glu Leu Pro Trp Gly Arg Gly 
            20                  25                  30          


Arg Glu Asp Pro Ser Pro Glu Thr Phe Arg Leu Arg Phe Arg Gln Phe 
        35                  40                  45              


Arg Tyr Gln Glu Ala Ala Gly Pro Gln Glu Ala Leu Arg Glu Leu Gln 
    50                  55                  60                  


Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu Leu His Thr Lys Glu Gln 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Thr Ile Leu Pro Arg 
                85                  90                  95      


Glu Phe Tyr Ala Trp Ile Arg Glu His Gly Pro Glu Ser Gly Lys Ala 
            100                 105                 110         


Leu Ala Ala Met Val Glu Asp Leu Thr Glu Arg Ala Leu Glu Ala Lys 
        115                 120                 125             


Ala Val Pro Cys His Arg Gln Gly Glu Gln Glu Glu Thr Ala Leu Cys 
    130                 135                 140                 


Arg Gly Ala Trp Glu Pro Gly Ile Gln Leu Gly Pro Val Glu Val Lys 
145                 150                 155                 160 


Pro Glu Trp Gly Met Pro Pro Gly Glu Gly Val Gln Gly Pro Asp Pro 
                165                 170                 175     


Gly Thr Glu Glu Gln Leu Ser Gln Asp Pro Gly Asp Glu Thr Arg Ala 
            180                 185                 190         


Phe Gln Glu Gln Ala Leu Pro Val Leu Gln Ala Gly Pro Gly Leu Pro 
        195                 200                 205             


Ala Val Asn Pro Arg Asp Gln Glu Met Ala Ala Gly Phe Phe Thr Ala 
    210                 215                 220                 


Gly Ser Gln Gly Leu Gly Pro Phe Lys Asp Met Ala Leu Ala Phe Pro 
225                 230                 235                 240 


Glu Glu Glu Trp Arg His Val Thr Pro Ala Gln Ile Asp Cys Phe Gly 
                245                 250                 255     


Glu Tyr Val Glu Pro Gln Asp Cys Arg Val Ser Pro Gly Gly Gly Ser 
            260                 265                 270         


Lys Glu Lys Glu Ala Lys Pro Pro Gln Glu Asp Leu Lys Gly Ala Leu 
        275                 280                 285             


Val Ala Leu Thr Ser Glu Arg Phe Gly Glu Ala Ser Leu Gln Gly Pro 
    290                 295                 300                 


Gly Leu Gly Arg Val Cys Glu Gln Glu Pro Gly Gly Pro Ala Gly Ser 
305                 310                 315                 320 


Ala Pro Gly Leu Pro Pro Pro Gln His Gly Ala Ile Pro Leu Pro Asp 
                325                 330                 335     


Glu Val Lys Thr His Ser Ser Phe Trp Lys Pro Phe Gln Cys Pro Glu 
            340                 345                 350         


Cys Gly Lys Gly Phe Ser Arg Ser Ser Asn Leu Val Arg His Gln Arg 
        355                 360                 365             


Thr His Glu Glu Lys Ser Tyr Gly Cys Val Glu Cys Gly Lys Gly Phe 
    370                 375                 380                 


Thr Leu Arg Glu Tyr Leu Met Lys His Gln Arg Thr His Leu Gly Lys 
385                 390                 395                 400 


Arg Pro Tyr Val Cys Ser Glu Cys Trp Lys Thr Phe Ser Gln Arg His 
                405                 410                 415     


His Leu Glu Val His Gln Arg Ser His Thr Gly Glu Lys Pro Tyr Lys 
            420                 425                 430         


Cys Gly Asp Cys Trp Lys Ser Phe Ser Arg Arg Gln His Leu Gln Val 
        435                 440                 445             


His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Glu Cys Gly 
    450                 455                 460                 


Lys Ser Phe Ser Arg Asn Ala Asn Leu Ala Val His Arg Arg Ala His 
465                 470                 475                 480 


Thr Gly Glu Lys Pro Tyr Gly Cys Gln Val Cys Gly Lys Arg Phe Ser 
                485                 490                 495     


Lys Gly Glu Arg Leu Val Arg His Gln Arg Ile His Thr Gly Glu Lys 
            500                 505                 510         


Pro Tyr His Cys Pro Ala Cys Gly Arg Ser Phe Asn Gln Arg Ser Ile 
        515                 520                 525             


Leu Asn Arg His Gln Lys Thr Gln His Arg Gln Glu Pro Leu Val Gln 
    530                 535                 540                 


<210>  841
<211>  1707
<212>  DNA
<213>  Homosapiens

<400>  841
gggaagctcc aggcaaacag cccagcaaac agcagcactc agctaaaagg aagactcaca     60

gaacacagtt gaagaaggaa agtggcgatg gacctcatcc caaatttggc ggtggaaacc    120

tggcttctcc tggctgtcag cctggtgctc ctctatctat atgggacccg tacacatgga    180

ctttttaaga gactgggaat tccagggccc acacctctgc ctttgttggg aaatgttttg    240

tcctatcgtc agggtctctg gaaatttgac acagagtgct ataaaaagta tggaaaaatg    300

tggggaacgt atgaaggtca actccctgtg ctggccatca cagatcccga cgtgatcaga    360

acagtgctag tgaaagaatg ttattctgtc ttcacaaatc gaaggtcttt aggcccagtg    420

ggatttatga aaagtgccat ctctttagct gaggatgaag aatggaagag aatacggtca    480

ttgctgtctc caaccttcac cagcggaaaa ctcaaggaga tgttccccat cattgcccag    540

tatggagatg tattggtgag aaacttgagg cgggaagcag agaaaggcaa gcctgtcacc    600

ttgaaagaca tctttggggc ctacagcatg gatgtgatta ctggcacatc atttggagtg    660

aacatcgact ctctcaacaa tccacaagac ccctttgtgg agagcactaa gaagttccta    720

aaatttggtt tcttagatcc attatttctc tcaataatac tctttccatt ccttacccca    780

gtttttgaag cattaaatgt ctctctgttt ccaaaagata ccataaattt tttaagtaaa    840

tctgtaaaca gaatgaagaa aagtcgcctc aacgacaaac aaaagcaccg actagatttc    900

cttcagctga tgattgactc ccagaattcg aaagaaactg agtcccacaa agctctgtct    960

gatctggagc tcgcagccca gtcaataatc ttcatttttg ctggctatga aaccaccagc   1020

agtgttcttt ccttcacttt atatgaactg gccactcacc ctgatgtcca gcagaaactg   1080

caaaaggaga ttgatgcagt tttgcccaat aaggcaccac ctacctatga tgccgtggta   1140

cagatggagt accttgacat ggtggtgaat gaaacactca gattattccc agttgctatt   1200

agacttgaga ggacttgcaa gaaagatgtt gaaatcaatg gggtattcat tcccaaaggg   1260

tcaatggtgg tgattccaac ttatgctctt caccatgacc caaagtactg gacagagcct   1320

gaggagttcc gccctgaaag gttcagtaag aagaaggaca gcatagatcc ttacatatac   1380

acaccctttg gaactggacc cagaaactgc attggcatga ggtttgctct catgaacatg   1440

aaacttgctc taatcagagt ccttcagaac ttctccttca aaccttgtaa agaaacacag   1500

atccccttga aattagacac gcaaggactt cttcaaccag aaaaacccat tgttctaaag   1560

gtggattcaa gagatggaac cctaagtgga gaatgagtta ttctaaggat ttctactttg   1620

gtcttcaaga aagctgtgcc ccagaacacc agagatttca acttagtcaa taaaaccttg   1680

aaataaagat gggcttaatc taatgta                                       1707


<210>  842
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  842

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly 
        35                  40                  45              


Asn Val Leu Ser Tyr Arg Gln Gly Leu Trp Lys Phe Asp Thr Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Phe Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Lys Gly Lys Pro Val Thr Leu Lys Asp Ile Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Gly Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Ser Thr Lys 
        195                 200                 205             


Lys Phe Leu Lys Phe Gly Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Val Ser Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Thr Ile Asn Phe Leu Ser Lys Ser Val Asn Arg Met 
                245                 250                 255     


Lys Lys Ser Arg Leu Asn Asp Lys Gln Lys His Arg Leu Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Ala Val Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Thr Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp Pro Tyr Ile Tyr Thr 
            420                 425                 430         


Pro Phe Gly Thr Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
        435                 440                 445             


Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
    450                 455                 460                 


Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Thr Gln Gly 
465                 470                 475                 480 


Leu Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val Asp Ser Arg Asp 
                485                 490                 495     


Gly Thr Leu Ser Gly Glu 
            500         


<210>  843
<211>  2080
<212>  DNA
<213>  Homosapiens

<400>  843
tcactgctgt gcagggcagg aaagctccac acacacagcc cagcaaacag cagcacgctg     60

ctgaaaaaaa gactcagagg agagagataa ggaaggaaag tagtgatgga tctcatccca    120

aacttggccg tggaaacctg gcttctcctg gctgtcagcc tgatactcct ctatctatat    180

ggaacccgta cacatggact ttttaagaag cttggaattc cagggcccac acctctgcct    240

tttttgggaa atgctttgtc cttccgtaag ggctattgga cgtttgacat ggaatgttat    300

aaaaagtata gaaaagtctg gggtatttat gactgtcaac agcctatgct ggctatcaca    360

gatcccgaca tgatcaaaac agtgctagtg aaagaatgtt attctgtctt cacaaaccgg    420

aggcctttcg ggccagtggg atttatgaaa aatgccatct ctatagctga ggatgaagaa    480

tggaagagaa tacgatcatt gctgtctcca acattcacca gcggaaaact caaggagatg    540

gtccctatca ttgcccagta tggagatgtg ttggtgagaa atctgaggcg ggaagcagag    600

acaggcaagc ctgtcacctt gaaacacgtc tttggggcct acagcatgga tgtgatcact    660

agcacatcat ttggagtgag catcgactct ctcaacaatc cacaagaccc ctttgtggaa    720

aacaccaaga agcttttaag atttaatcca ttagatccat tcgttctctc aataaaagtc    780

tttccattcc ttaccccaat tcttgaagca ttaaatatca ctgtgtttcc aagaaaagtt    840

ataagttttc taacaaaatc tgtaaaacag ataaaagaag gtcgcctcaa agagacacaa    900

aagcaccgag tggatttcct tcagctgatg attgactctc agaattcaaa agactctgag    960

acccacaaag ctctgtctga tctggagctc atggcccaat caattatctt tatttttgct   1020

ggctatgaaa ccacgagcag tgttctctcc ttcattatat atgaactggc cactcaccct   1080

gatgtccagc agaaagtgca gaaggaaatt gatacagttt tacccaataa ggcaccaccc   1140

acctatgata ctgtgctaca gttggagtat cttgacatgg tggtgaatga aacactcaga   1200

ttattcccag ttgctatgag acttgagagg gtctgcaaaa aagatgttga aatcaatggg   1260

atgtttattc ccaaaggggt ggtggtgatg attccaagct atgttcttca tcatgaccca   1320

aagtactgga cagagcctga gaagttcctc cctgaaaggt tcagtaaaaa gaacaaggac   1380

aacatagatc cttacatata cacacccttt ggaagtggac ccagaaactg cattggcatg   1440

aggtttgctc tcgtgaacat gaaacttgct ctagtcagag tccttcagaa cttctccttc   1500

aaaccttgta aagaaacaca gatccccctg aaattacgct ttggaggact tcttctaaca   1560

gaaaaaccca ttgttctaaa ggctgagtca agggatgaga ccgtaagtgg agcctgattt   1620

ccctaaggac ttctggtttg ctctttaaga aagctgtgcc ccagaacacc agagacctca   1680

aattacttta caaatagaac cctgaaatga agacgggctt catccaatgt gctgcataaa   1740

taatcaggga ttctgtacgt gcattgtgct ctctcatggt ctgtatagag tgttatactt   1800

ggtaatatag aggagatgac caaatcagtg ctggggaagt agatttggct tctctgcttc   1860

tcataggact atctccacca cccccagtta gcaccattaa ctcctcctga gctctgataa   1920

cataattaac atttctcaat aatttcaacc acaatcatta ataaaaatag gaattatttt   1980

gatggctcta acagtgacat ttatatcatg tgttatatct gtagtattct atagtaagct   2040

ttatattaag caaatcaata aaaacctctt tacaaaagta                         2080


<210>  844
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  844

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Ile Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ala Leu Ser Phe Arg Lys Gly Tyr Trp Thr Phe Asp Met Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Arg Lys Val Trp Gly Ile Tyr Asp Cys Gln Gln Pro 
65                  70                  75                  80  


Met Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Asn Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys His Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Ser 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asn Pro Leu Asp Pro Phe Val Leu Ser Ile Lys 
    210                 215                 220                 


Val Phe Pro Phe Leu Thr Pro Ile Leu Glu Ala Leu Asn Ile Thr Val 
225                 230                 235                 240 


Phe Pro Arg Lys Val Ile Ser Phe Leu Thr Lys Ser Val Lys Gln Ile 
                245                 250                 255     


Lys Glu Gly Arg Leu Lys Glu Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Asp Ser Glu Thr His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Met Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Ile Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Val Gln Lys Glu Ile Asp 
                325                 330                 335     


Thr Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Leu Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Val 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Val Asn Met Lys Leu Ala Leu Val Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Arg Phe Gly 
465                 470                 475                 480 


Gly Leu Leu Leu Thr Glu Lys Pro Ile Val Leu Lys Ala Glu Ser Arg 
                485                 490                 495     


Asp Glu Thr Val Ser Gly Ala 
            500             


<210>  845
<211>  2768
<212>  DNA
<213>  Homosapiens

<400>  845
cactgctgtg cagggcagga aagctccatg cacatagccc agcaaagagc aacacagagc     60

tgaaaggaag actcagagga gagagataag taaggaaagt agtgatggct ctcatcccag    120

acttggccat ggaaacctgg cttctcctgg ctgtcagcct ggtgctcctc tatctatatg    180

gaacccattc acatggactt tttaagaagc ttggaattcc agggcccaca cctctgcctt    240

ttttgggaaa tattttgtcc taccataagg gcttttgtat gtttgacatg gaatgtcata    300

aaaagtatgg aaaagtgtgg ggcttttatg atggtcaaca gcctgtgctg gctatcacag    360

atcctgacat gatcaaaaca gtgctagtga aagaatgtta ttctgtcttc acaaaccgga    420

ggccttttgg tccagtggga tttatgaaaa gtgccatctc tatagctgag gatgaagaat    480

ggaagagatt acgatcattg ctgtctccaa ccttcaccag tggaaaactc aaggagatgg    540

tccctatcat tgcccagtat ggagatgtgt tggtgagaaa tctgaggcgg gaagcagaga    600

caggcaagcc tgtcaccttg aaagacgtct ttggggccta cagcatggat gtgatcacta    660

gcacatcatt tggagtgaac atcgactctc tcaacaatcc acaagacccc tttgtggaaa    720

acaccaagaa gcttttaaga tttgattttt tggatccatt ctttctctca ataacagtct    780

ttccattcct catcccaatt cttgaagtat taaatatctg tgtgtttcca agagaagtta    840

caaatttttt aagaaaatct gtaaaaagga tgaaagaaag tcgcctcgaa gatacacaaa    900

agcaccgagt ggatttcctt cagctgatga ttgactctca gaattcaaaa gaaactgagt    960

cccacaaagc tctgtccgat ctggagctcg tggcccaatc aattatcttt atttttgctg   1020

gctatgaaac cacgagcagt gttctctcct tcattatgta tgaactggcc actcaccctg   1080

atgtccagca gaaactgcag gaggaaattg atgcagtttt acccaataag gcaccaccca   1140

cctatgatac tgtgctacag atggagtatc ttgacatggt ggtgaatgaa acgctcagat   1200

tattcccaat tgctatgaga cttgagaggg tctgcaaaaa agatgttgag atcaatggga   1260

tgttcattcc caaaggggtg gtggtgatga ttccaagcta tgctcttcac cgtgacccaa   1320

agtactggac agagcctgag aagttcctcc ctgaaagatt cagcaagaag aacaaggaca   1380

acatagatcc ttacatatac acaccctttg gaagtggacc cagaaactgc attggcatga   1440

ggtttgctct catgaacatg aaacttgctc taatcagagt ccttcagaac ttctccttca   1500

aaccttgtaa agaaacacag atccccctga aattaagctt aggaggactt cttcaaccag   1560

aaaaacccgt tgttctaaag gttgagtcaa gggatggcac cgtaagtgga gcctgaattt   1620

tcctaaggac ttctgctttg ctcttcaaga aatctgtgcc tgagaacacc agagacctca   1680

aattactttg tgaatagaac tctgaaatga agatgggctt catccaatgg actgcataaa   1740

taaccgggga ttctgtacat gcattgagct ctctcattgt ctgtgtagag tgttatactt   1800

gggaatataa aggaggtgac caaatcagtg tgaggaggta gatttggctc ctctgcttct   1860

cacgggacta tttccaccac ccccagttag caccattaac tcctcctgag ctctgataag   1920

agaatcaaca tttctcaata atttcctcca caaattatta atgaaaataa gaattatttt   1980

gatggctcta acaatgacat ttatatcaca tgttttctct ggagtattct ataagtttta   2040

tgttaaatca ataaagacca ctttacaaaa gtattatcag atgctttcct gcacattaag   2100

gagaaatcta tagaactgaa tgagaaccaa caagtaaata tttttggtca ttgtaatcac   2160

tgttggcgtg gggcctttgt cagaactaga atttgattat taacataggt gaaagttaat   2220

ccactgtgac tttgcccatt gtttagaaag aatattcata gtttaattat gccttttttg   2280

atcaggcaca gtggctcacg cctgtaatcc tagcagtttg ggaggctgag ccgggtggat   2340

cgcctgaggt caggagttca agacaagcct ggcctacatg gttgaaaccc catctctact   2400

aaaaatacac aaattagcta ggcatggtgg actcgcctgt aatctcacta cacaggaggc   2460

tgaggcagga gaatcacttg aacctgggag gcggatgttg aagtgagctg agattgcacc   2520

actgcactcc agtctgggtg agagtgagac tcagtcttaa aaaaatatgc ctttttgaag   2580

cacgtacatt ttgtaacaaa gaactgaagc tcttattata ttattagttt tgatttaatg   2640

ttttcagccc atctcctttc atatttctgg gagacagaaa acatgtttcc ctacacctct   2700

tgcattccat cctcaacacc caactgtctc gatgcaatga acacttaata aaaaacagtc   2760

gattggtc                                                            2768


<210>  846
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  846

Met Ala Leu Ile Pro Asp Leu Ala Met Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr His Ser His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ile Leu Ser Tyr His Lys Gly Phe Cys Met Phe Asp Met Glu Cys 
    50                  55                  60                  


His Lys Lys Tyr Gly Lys Val Trp Gly Phe Tyr Asp Gly Gln Gln Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Leu Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys Asp Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asp Phe Leu Asp Pro Phe Phe Leu Ser Ile Thr 
    210                 215                 220                 


Val Phe Pro Phe Leu Ile Pro Ile Leu Glu Val Leu Asn Ile Cys Val 
225                 230                 235                 240 


Phe Pro Arg Glu Val Thr Asn Phe Leu Arg Lys Ser Val Lys Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Glu Asp Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Ile Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Ala 
385                 390                 395                 400 


Leu His Arg Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Leu Gly 
465                 470                 475                 480 


Gly Leu Leu Gln Pro Glu Lys Pro Val Val Leu Lys Val Glu Ser Arg 
                485                 490                 495     


Asp Gly Thr Val Ser Gly Ala 
            500             


<210>  847
<211>  2167
<212>  DNA
<213>  Homosapiens

<400>  847
acctctgggc agagaaacaa agctctatat gcacagccca gcaaagagca gcacacagct     60

gaaagaaaaa ctcagaagac agagctgaaa aagaaaactg gtgatggatc tcattccaaa    120

ctttgccatg gaaacatggg ttcttgtggc taccagcctg gtactcctct atatttatgg    180

gacccattca cataaacttt ttaagaagct gggaattcct gggccaaccc ctctgccttt    240

tctgggaact attttgttct accttagggg tctttggaat tttgacagag aatgtaatga    300

aaaatacgga gaaatgtggg ggctgtatga ggggcaacag cccatgctgg tcatcatgga    360

tcccgacatg atcaaaacag tgttagtgaa agaatgttac tctgtcttca caaaccagat    420

gcctttaggt ccaatgggat ttctgaaaag tgccttaagt tttgctgaag atgaagaatg    480

gaagagaata cgaacattgc tatctccagc tttcaccagt gtaaaattca aggaaatggt    540

ccccatcatt tcccaatgtg gagatatgtt ggtgagaagc ctgaggcagg aagcagagaa    600

cagcaagtcc atcaacttga aagatttctt tggggcctac accatggatg taatcactgg    660

cacattattt ggagtgaact tggattctct caacaatcca caagatccct ttctgaaaaa    720

tatgaagaag cttttaaaat tggatttttt ggatcccttt ttactcttaa tatcactctt    780

tccatttctt accccagttt ttgaagccct aaatatcggt ttgtttccaa aagatgttac    840

ccatttttta aaaaattcca ttgaaaggat gaaagaaagt cgcctcaaag ataaacaaaa    900

gcatcgagta gatttctttc aacagatgat cgactcccag aattccaaag aaacaaagtc    960

ccataaagct ctgtctgatc tggagcttgt ggcccagtca attatcatca tttttgctgc   1020

ctatgacaca actagcacca ctctcccctt cattatgtat gaactggcca ctcaccctga   1080

tgtccagcag aaactgcagg aggagattga cgcagtttta cccaataagg cacctgtcac   1140

ctacgatgcc ctggtacaga tggagtacct tgacatggtg gtgaatgaaa cgctcagatt   1200

attcccagtt gttagtagag ttacgagagt ctgcaagaaa gatattgaaa tcaatggagt   1260

gttcattccc aaagggttag cagtgatggt tccaatctat gctcttcacc atgacccaaa   1320

gtactggaca gagcctgaga agttctgccc tgaaagtagg ttcagtaaga agaacaagga   1380

cagcatagat ctttacagat acataccttt tggagctgga ccccgaaact gcattggcat   1440

gaggtttgct ctcacaaaca taaaacttgc tgtcattaga gcactgcaga acttctcctt   1500

caaaccttgt aaagagactc agatcccact gaaattagac aatctaccaa ttcttcaacc   1560

agaaaaacct attgttctaa aagtgcactt aagagatggg attacaagtg gaccctgact   1620

ttccctaagg acttccactt tgttcaagaa agctgtatcc cagaacacta gacacttcaa   1680

attgttttgt gaataaaact cagaaatgaa gatgagctta attaacctag tatactgggt   1740

gaataattag aaattctcta cattcattga gctctcattg tctgggtaga gtattacacg   1800

ttgcatacta caaagcaggt gacaaatcaa tgccaaataa gtacagtcat cttctctagt   1860

tctcataaga ctatctcccc gccacctata gttagtaccc tcaagtcctc ctgagctgtg   1920

atcagagaat aaacatttct caacaatttt accaacaatt tttaatgaaa aggaaaatta   1980

tacttgtgat tctcgtagtg acatttatat tacatgttcc atttgtgata ttctataata   2040

agtattatat tgagaaagtc aacaagcacc tctttacaaa actgttatct gatgtcttcc   2100

tgcatattaa ggatgaatct acagaattag atcaataagg atcaacaaat aaatattttt   2160

ggtcatt                                                             2167


<210>  848
<211>  504
<212>  PRT
<213>  Homosapiens

<400>  848

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Gly Leu Trp Asn Phe Asp Arg Glu Cys 
    50                  55                  60                  


Asn Glu Lys Tyr Gly Glu Met Trp Gly Leu Tyr Glu Gly Gln Gln Pro 
65                  70                  75                  80  


Met Leu Val Ile Met Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Gln Met Pro Leu Gly Pro Met Gly 
            100                 105                 110         


Phe Leu Lys Ser Ala Leu Ser Phe Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Thr Leu Leu Ser Pro Ala Phe Thr Ser Val Lys Phe Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ser Gln Cys Gly Asp Met Leu Val Arg Ser Leu 
145                 150                 155                 160 


Arg Gln Glu Ala Glu Asn Ser Lys Ser Ile Asn Leu Lys Asp Phe Phe 
                165                 170                 175     


Gly Ala Tyr Thr Met Asp Val Ile Thr Gly Thr Leu Phe Gly Val Asn 
            180                 185                 190         


Leu Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Leu Lys Asn Met Lys 
        195                 200                 205             


Lys Leu Leu Lys Leu Asp Phe Leu Asp Pro Phe Leu Leu Leu Ile Ser 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile Gly Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp Phe Phe 
            260                 265                 270         


Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile Ile Phe 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Cys Pro 
                405                 410                 415     


Glu Ser Arg Phe Ser Lys Lys Asn Lys Asp Ser Ile Asp Leu Tyr Arg 
            420                 425                 430         


Tyr Ile Pro Phe Gly Ala Gly Pro Arg Asn Cys Ile Gly Met Arg Phe 
        435                 440                 445             


Ala Leu Thr Asn Ile Lys Leu Ala Val Ile Arg Ala Leu Gln Asn Phe 
    450                 455                 460                 


Ser Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Asn 
465                 470                 475                 480 


Leu Pro Ile Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val His Leu 
                485                 490                 495     


Arg Asp Gly Ile Thr Ser Gly Pro 
            500                 


<210>  849
<211>  2164
<212>  DNA
<213>  Homosapiens

<400>  849
acctctgggc agagaaacaa agctctatat gcacagccca gcaaagagca gcacacagct     60

gaaagaaaaa ctcagaagac agagctgaaa aagaaaactg gtgatggatc tcattccaaa    120

ctttgccatg gaaacatggg ttcttgtggc taccagcctg gtactcctct atatttatgg    180

gacccattca cataaacttt ttaagaagct gggaattcct gggccaaccc ctctgccttt    240

tctgggaact attttgttct accttagggg tctttggaat tttgacagag aatgtaatga    300

aaaatacgga gaaatgtggg ggctgtatga ggggcaacag cccatgctgg tcatcatgga    360

tcccgacatg atcaaaacag tgttagtgaa agaatgttac tctgtcttca caaaccagat    420

gcctttaggt ccaatgggat ttctgaaaag tgccttaagt tttgctgaag atgaagaatg    480

gaagagaata cgaacattgc tatctccagc tttcaccagt gtaaaattca aggaaatggt    540

ccccatcatt tcccaatgtg gagatatgtt ggtgagaagc ctgaggcagg aagcagagaa    600

cagcaagtcc atcaacttga aagatttctt tggggcctac accatggatg taatcactgg    660

cacattattt ggagtgaact tggattctct caacaatcca caagatccct ttctgaaaaa    720

tatgaagaag cttttaaaat tggatttttt ggatcccttt ttactcttaa tatcactctt    780

tccatttctt accccagttt ttgaagccct aaatatcggt ttgtttccaa aagatgttac    840

ccatttttta aaaaattcca ttgaaaggat gaaagaaagt cgcctcaaag ataaacaaaa    900

gcatcgagta gatttctttc aacagatgat cgactcccag aattccaaag aaacaaagtc    960

ccataaagct ctgtctgatc tggagcttgt ggcccagtca attatcatca tttttgctgc   1020

ctatgacaca actagcacca ctctcccctt cattatgtat gaactggcca ctcaccctga   1080

tgtccagcag aaactgcagg aggagattga cgcagtttta cccaataagg cacctgtcac   1140

ctacgatgcc ctggtacaga tggagtacct tgacatggtg gtgaatgaaa cgctcagatt   1200

attcccagtt gttagtagag ttacgagagt ctgcaagaaa gatattgaaa tcaatggagt   1260

gttcattccc aaagggttag cagtgatggt tccaatctat gctcttcacc atgacccaaa   1320

gtactggaca gagcctgaga agttctgccc tgaaaggttc agtaagaaga acaaggacag   1380

catagatctt tacagataca taccttttgg agctggaccc cgaaactgca ttggcatgag   1440

gtttgctctc acaaacataa aacttgctgt cattagagca ctgcagaact tctccttcaa   1500

accttgtaaa gagactcaga tcccactgaa attagacaat ctaccaattc ttcaaccaga   1560

aaaacctatt gttctaaaag tgcacttaag agatgggatt acaagtggac cctgactttc   1620

cctaaggact tccactttgt tcaagaaagc tgtatcccag aacactagac acttcaaatt   1680

gttttgtgaa taaaactcag aaatgaagat gagcttaatt aacctagtat actgggtgaa   1740

taattagaaa ttctctacat tcattgagct ctcattgtct gggtagagta ttacacgttg   1800

catactacaa agcaggtgac aaatcaatgc caaataagta cagtcatctt ctctagttct   1860

cataagacta tctccccgcc acctatagtt agtaccctca agtcctcctg agctgtgatc   1920

agagaataaa catttctcaa caattttacc aacaattttt aatgaaaagg aaaattatac   1980

ttgtgattct cgtagtgaca tttatattac atgttccatt tgtgatattc tataataagt   2040

attatattga gaaagtcaac aagcacctct ttacaaaact gttatctgat gtcttcctgc   2100

atattaagga tgaatctaca gaattagatc aataaggatc aacaaataaa tatttttggt   2160

catt                                                                2164


<210>  850
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  850

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Gly Leu Trp Asn Phe Asp Arg Glu Cys 
    50                  55                  60                  


Asn Glu Lys Tyr Gly Glu Met Trp Gly Leu Tyr Glu Gly Gln Gln Pro 
65                  70                  75                  80  


Met Leu Val Ile Met Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Gln Met Pro Leu Gly Pro Met Gly 
            100                 105                 110         


Phe Leu Lys Ser Ala Leu Ser Phe Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Thr Leu Leu Ser Pro Ala Phe Thr Ser Val Lys Phe Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ser Gln Cys Gly Asp Met Leu Val Arg Ser Leu 
145                 150                 155                 160 


Arg Gln Glu Ala Glu Asn Ser Lys Ser Ile Asn Leu Lys Asp Phe Phe 
                165                 170                 175     


Gly Ala Tyr Thr Met Asp Val Ile Thr Gly Thr Leu Phe Gly Val Asn 
            180                 185                 190         


Leu Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Leu Lys Asn Met Lys 
        195                 200                 205             


Lys Leu Leu Lys Leu Asp Phe Leu Asp Pro Phe Leu Leu Leu Ile Ser 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile Gly Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp Phe Phe 
            260                 265                 270         


Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile Ile Phe 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Cys Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Ser Ile Asp Leu Tyr Arg Tyr 
            420                 425                 430         


Ile Pro Phe Gly Ala Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Thr Asn Ile Lys Leu Ala Val Ile Arg Ala Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Asn Leu 
465                 470                 475                 480 


Pro Ile Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val His Leu Arg 
                485                 490                 495     


Asp Gly Ile Thr Ser Gly Pro 
            500             


<210>  851
<211>  2001
<212>  DNA
<213>  Homosapiens

<400>  851
acctctgggc agagaaacaa agctctatat gcacagccca gcaaagagca gcacacagct     60

gaaagaaaaa ctcagaagac agagctgaaa aagaaaactg gtgatggatc tcattccaaa    120

ctttgccatg gaaacatggg ttcttgtggc taccagcctg gtactcctct atatttatgg    180

gacccattca cataaacttt ttaagaagct gggaattcct gggccaaccc ctctgccttt    240

tctgggaact attttgttct accttagggg tctttggaat tttgacagag aatgtaatga    300

aaaatacgga gaaatgtggg ggctgtatga ggggcaacag cccatgctgg tcatcatgga    360

tcccgacatg atcaaaacag tgttagtgaa agaatgttac tctgtcttca caaaccagat    420

gcctttaggt ccaatgggat ttctgaaaag tgccttaagt tttgctgaag atgaagaatg    480

gaagagaata cgaacattgc tatctccagc tttcaccagt gtaaaattca aggaaatggt    540

ccccatcatt tcccaatgtg gagatatgtt ggtgagaagc ctgaggcagg aagcagagaa    600

cagcaagtcc atcaacttga aagatttctt tggggcctac accatggatg taatcactgg    660

cacattattt ggagtgaact tggattctct caacaatcca caagatccct ttctgaaaaa    720

tatgaagaag cttttaaaat tggatttttt ggatcccttt ttactcttaa tatcactctt    780

tccatttctt accccagttt ttgaagccct aaatatcggt ttgtttccaa aagatgttac    840

ccatttttta aaaaattcca ttgaaaggat gaaagaaagt cgcctcaaag ataaacaaaa    900

gcatcgagta gatttctttc aacagatgat cgactcccag aattccaaag aaacaaagtc    960

ccataaagct ctgtctgatc tggagcttgt ggcccagtca attatcatca tttttgctgc   1020

ctatgacaca actagcacca ctctcccctt cattatgtat gaactggcca ctcaccctga   1080

tgtccagcag aaactgcagg aggagattga cgcagtttta cccaataagg cacctgtcac   1140

ctacgatgcc ctggtacaga tggagtacct tgacatggtg gtgaatgaaa cgctcagatt   1200

attcccagtt gttagtagag ttacgagagt ctgcaagaaa gatattgaaa tcaatggagt   1260

gttcattccc aaagggttag cagtgatggt tccaatctat gctcttcacc atgacccaaa   1320

gtactggaca gagcctgaga agttctgccc tgaaagatcc cactgaaatt agacaatcta   1380

ccaattcttc aaccagaaaa acctattgtt ctaaaagtgc acttaagaga tgggattaca   1440

agtggaccct gactttccct aaggacttcc actttgttca agaaagctgt atcccagaac   1500

actagacact tcaaattgtt ttgtgaataa aactcagaaa tgaagatgag cttaattaac   1560

ctagtatact gggtgaataa ttagaaattc tctacattca ttgagctctc attgtctggg   1620

tagagtatta cacgttgcat actacaaagc aggtgacaaa tcaatgccaa ataagtacag   1680

tcatcttctc tagttctcat aagactatct ccccgccacc tatagttagt accctcaagt   1740

cctcctgagc tgtgatcaga gaataaacat ttctcaacaa ttttaccaac aatttttaat   1800

gaaaaggaaa attatacttg tgattctcgt agtgacattt atattacatg ttccatttgt   1860

gatattctat aataagtatt atattgagaa agtcaacaag cacctcttta caaaactgtt   1920

atctgatgtc ttcctgcata ttaaggatga atctacagaa ttagatcaat aaggatcaac   1980

aaataaatat ttttggtcat t                                             2001


<210>  852
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  852

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Gly Leu Trp Asn Phe Asp Arg Glu Cys 
    50                  55                  60                  


Asn Glu Lys Tyr Gly Glu Met Trp Gly Leu Tyr Glu Gly Gln Gln Pro 
65                  70                  75                  80  


Met Leu Val Ile Met Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Gln Met Pro Leu Gly Pro Met Gly 
            100                 105                 110         


Phe Leu Lys Ser Ala Leu Ser Phe Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Thr Leu Leu Ser Pro Ala Phe Thr Ser Val Lys Phe Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ser Gln Cys Gly Asp Met Leu Val Arg Ser Leu 
145                 150                 155                 160 


Arg Gln Glu Ala Glu Asn Ser Lys Ser Ile Asn Leu Lys Asp Phe Phe 
                165                 170                 175     


Gly Ala Tyr Thr Met Asp Val Ile Thr Gly Thr Leu Phe Gly Val Asn 
            180                 185                 190         


Leu Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Leu Lys Asn Met Lys 
        195                 200                 205             


Lys Leu Leu Lys Leu Asp Phe Leu Asp Pro Phe Leu Leu Leu Ile Ser 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile Gly Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp Phe Phe 
            260                 265                 270         


Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile Ile Phe 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Cys Pro 
                405                 410                 415     


Glu Arg Ser His 
            420 


<210>  853
<211>  3323
<212>  DNA
<213>  Homosapiens

<400>  853
tgcgttgtac ccttttacgt gaggcggtga cggcggttcg gaagtcgtct ggcctccccg     60

cggccgctcg cagcttgctg gcctctcccg cgcctcacgt cggactccgt ctccgcggca    120

gggaagcagc atggaagctg aggacatcca ggaggagttg acctgcccca tctgcctgga    180

ctatttccag gacccggtgt ccatcgagtg cggccacaac ttctgccgcg gctgcctgca    240

ccgcaactgg gcgccgggcg gcggcccgtt cccctgcccc gaatgtcggc acccatcggc    300

gcccgccgcg ctgcgaccca actgggccct ggccaggctg actgagaaga cgcagcgccg    360

gcgcctgggc cccgtgcccc cgggcctgtg cggccgccac tgggagccgc tgcggctctt    420

ctgcgaggac gaccagcggc cagtgtgcct ggtgtgcagg gagtcccagg agcaccagac    480

tcacgccatg gcacccatcg acgaggcctt cgagagctac cgggagaaac ttcttaagtc    540

tcagcgtaat ctcgtggcca agatgaagaa agtcatgcat ttacaggatg tagaagtgaa    600

gaacgccaca cagtggaagg ataagataaa gagtcagcga atgagaatca gcacggagtt    660

ttcaaagctg cacaacttcc tggttgaaga agaggacctg tttcttcaga gattgaacaa    720

agaagaagaa gagacgaaga agaagctgaa tgagaacacg ttaaaactca atcaaactat    780

cgcttcattg aagaagctca tcttagaggt gggggagaag agccaggctc ccaccctgga    840

gctgcttcag aatccaaaag aagtgttgac caggagtgag atccaggatg tgaactattc    900

ccttgaagct gtgaaggtga agacagtgtg ccagatacca ttgatgaagg aaatgctaaa    960

gcgattccaa gtggctgtaa acctagctga agacacagct catcccaaac tcgtcttctc   1020

ccaggaaggg agatacgtga aaaatacagc atcagccagt tcttggccag tgttttcttc   1080

agcatggaac tactttgctg gatggaggaa tcctcagaag actgcttttg tagagagatt   1140

tcagcactta ccctgtgttc tgggaaaaaa cgttttcacc tcagggaaac attactggga   1200

agttgagagt agagatagtc tggaggttgc tgttggggtg tgtcgggagg acgtcatggg   1260

aattactgat cgttcaaaaa tgtccccaga tgtgggcatc tgggcgattt attggagtgc   1320

tgctggctat tggcccttga taggcttccc tggaactccc acccagcaag agccagctct   1380

ccaccgagtg ggggtttacc tggatcgtgg gactgggaat gtctccttct acagcgctgt   1440

ggacggagtg cacctgcaca ccttttcttg ttcttctgtc tcacgcctcc ggccattttt   1500

ttggttgagt ccattagcat ctttagtcat tccaccagtg actgatagga aatgaggctt   1560

ttcttcccct gaccaaaact ccttccctgt agtccagctg agggacacac atccctgggc   1620

cctcttctgc ccttcatgtc tctatcctgg atggtccatc ttctgggtct ccctaacggt   1680

accgtttggt atctgccctt tgtgtgcttc acaagaggca gtcccatggg aggtgggtct   1740

ggccaatgga gatgggacag gaaattttcc aagacgcttt tgggaaatct ttttgtagct   1800

tttaaagaga tgtgcgggga agacatatgg atgttagcag ccatattgga actgagaaca   1860

caggaatggt ggaaaggtag aagaaacaga gtttttgttg ccgttgtgaa attgttgaaa   1920

tttccttcat gccaagcttc ttgttatatg agataattac gcccttattg tataagacaa   1980

ttttagttgt atttggttac ttgcagcctg aagtaccgta actgcactaa agggacgtag   2040

tgtgaacatc ccgcagtata ggcttaagtc acttttgtga aatttgacaa aggcatagaa   2100

tctttttcta tccagtcagg cattgcctat tctttccagt aactactgat tcccccactt   2160

ttctgtctta gaaaattgtg ggaatccccc ctcactctgc ctatgttgca ctctctctct   2220

tcccaaccat aactctgccc tcagctatta actgtgctgt gtatttatca agttggtatg   2280

ttgtatgtac agtgttattc atgtcatcat gagaatgttg aacgcttgtt aaataccttt   2340

tgctagcctc ttcatatgct gttgcatatg actctcatca caactcagtg agatggaaag   2400

acaaatccta tttgtacaaa tgagaaaact gaactcttta gagtaactag ctcagtattg   2460

gccagctggt aaatggcagt gttgggatta aaatccagtt cttatctact ctccctttat   2520

tcagaagcat ttattggatg ttgatctttg tttcaggttt tgattttgtt acttttttat   2580

actgtgtata ttttcctcag tctacccttc tgctctagat tgtctggact caggagattg   2640

tggcagttac tggatagtta tttttaagat aatgattgct tttctctgtt tatataagtc   2700

atgtgtactt attgtagaaa gtttgtaaga tgcaaaaagt ataaaaatta aagttatgca   2760

ctactaacat ttcaatatat tttctcccag attttcaata aagactttca ggcagtgatt   2820

taacgaggat tttattttaa cttatatttt agtttaaggg gaacacgtgc aggtttgttc   2880

tatagatcaa ttacatgtca caggggtttg gtgtacatat tatttcatta cccaggtaat   2940

aagcatagta cccaatagat acttttttga taccccaccc tcctccaccc tctaccctca   3000

agtagtccct ggtgtctgtt gttccctttt ttgtgtccat gggtactcaa tgtttagctc   3060

tcccttatac gtgagaacat gtgatgtttg gttttctgtt catgtgttgg tttgcttagg   3120

gtaatggcct ccagctccat ccatgttgct gcaaagacat gatctcattc tttttttatg   3180

gctgcatagt attccatggt gtatatgtac tatgttttct ttatccagtc tactgttgat   3240

gggcatttag gttgattcca tgtctttgct attgtgaata gtgctgcaat gaatatatac   3300

atgcaaaaaa aaaaaaaaaa aaa                                           3323


<210>  854
<211>  474
<212>  PRT
<213>  Homosapiens

<400>  854

Met Glu Ala Glu Asp Ile Gln Glu Glu Leu Thr Cys Pro Ile Cys Leu 
1               5                   10                  15      


Asp Tyr Phe Gln Asp Pro Val Ser Ile Glu Cys Gly His Asn Phe Cys 
            20                  25                  30          


Arg Gly Cys Leu His Arg Asn Trp Ala Pro Gly Gly Gly Pro Phe Pro 
        35                  40                  45              


Cys Pro Glu Cys Arg His Pro Ser Ala Pro Ala Ala Leu Arg Pro Asn 
    50                  55                  60                  


Trp Ala Leu Ala Arg Leu Thr Glu Lys Thr Gln Arg Arg Arg Leu Gly 
65                  70                  75                  80  


Pro Val Pro Pro Gly Leu Cys Gly Arg His Trp Glu Pro Leu Arg Leu 
                85                  90                  95      


Phe Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser 
            100                 105                 110         


Gln Glu His Gln Thr His Ala Met Ala Pro Ile Asp Glu Ala Phe Glu 
        115                 120                 125             


Ser Tyr Arg Glu Lys Leu Leu Lys Ser Gln Arg Asn Leu Val Ala Lys 
    130                 135                 140                 


Met Lys Lys Val Met His Leu Gln Asp Val Glu Val Lys Asn Ala Thr 
145                 150                 155                 160 


Gln Trp Lys Asp Lys Ile Lys Ser Gln Arg Met Arg Ile Ser Thr Glu 
                165                 170                 175     


Phe Ser Lys Leu His Asn Phe Leu Val Glu Glu Glu Asp Leu Phe Leu 
            180                 185                 190         


Gln Arg Leu Asn Lys Glu Glu Glu Glu Thr Lys Lys Lys Leu Asn Glu 
        195                 200                 205             


Asn Thr Leu Lys Leu Asn Gln Thr Ile Ala Ser Leu Lys Lys Leu Ile 
    210                 215                 220                 


Leu Glu Val Gly Glu Lys Ser Gln Ala Pro Thr Leu Glu Leu Leu Gln 
225                 230                 235                 240 


Asn Pro Lys Glu Val Leu Thr Arg Ser Glu Ile Gln Asp Val Asn Tyr 
                245                 250                 255     


Ser Leu Glu Ala Val Lys Val Lys Thr Val Cys Gln Ile Pro Leu Met 
            260                 265                 270         


Lys Glu Met Leu Lys Arg Phe Gln Val Ala Val Asn Leu Ala Glu Asp 
        275                 280                 285             


Thr Ala His Pro Lys Leu Val Phe Ser Gln Glu Gly Arg Tyr Val Lys 
    290                 295                 300                 


Asn Thr Ala Ser Ala Ser Ser Trp Pro Val Phe Ser Ser Ala Trp Asn 
305                 310                 315                 320 


Tyr Phe Ala Gly Trp Arg Asn Pro Gln Lys Thr Ala Phe Val Glu Arg 
                325                 330                 335     


Phe Gln His Leu Pro Cys Val Leu Gly Lys Asn Val Phe Thr Ser Gly 
            340                 345                 350         


Lys His Tyr Trp Glu Val Glu Ser Arg Asp Ser Leu Glu Val Ala Val 
        355                 360                 365             


Gly Val Cys Arg Glu Asp Val Met Gly Ile Thr Asp Arg Ser Lys Met 
    370                 375                 380                 


Ser Pro Asp Val Gly Ile Trp Ala Ile Tyr Trp Ser Ala Ala Gly Tyr 
385                 390                 395                 400 


Trp Pro Leu Ile Gly Phe Pro Gly Thr Pro Thr Gln Gln Glu Pro Ala 
                405                 410                 415     


Leu His Arg Val Gly Val Tyr Leu Asp Arg Gly Thr Gly Asn Val Ser 
            420                 425                 430         


Phe Tyr Ser Ala Val Asp Gly Val His Leu His Thr Phe Ser Cys Ser 
        435                 440                 445             


Ser Val Ser Arg Leu Arg Pro Phe Phe Trp Leu Ser Pro Leu Ala Ser 
    450                 455                 460                 


Leu Val Ile Pro Pro Val Thr Asp Arg Lys 
465                 470                 


<210>  855
<211>  3401
<212>  DNA
<213>  Homosapiens

<400>  855
tgcgttgtac ccttttacgt gaggcggtga cggcggttcg gaagtcgtct ggcctccccg     60

cggccgctcg cagcttgctg gcctctcccg cgcctcacgt cggactccgt ctccgcggca    120

gggaagcagc atggaagctg aggacatcca ggaggagttg acctgcccca tctgcctgga    180

ctatttccag gacccggtgt ccatcgagtg cggccacaac ttctgccgcg gctgcctgca    240

ccgcaactgg gcgccgggcg gcggcccgtt cccctgcccc gaatgtcggc acccatcggc    300

gcccgccgcg ctgcgaccca actgggccct ggccaggctg actgagaaga cgcagcgccg    360

gcgcctgggc cccgtgcccc cgggcctgtg cggccgccac tgggagccgc tgcggctctt    420

ctgcgaggac gaccagcggc cagtgtgcct ggtgtgcagg gagtcccagg agcaccagac    480

tcacgccatg gcacccatcg acgaggcctt cgagagctac cggacaggta actttgacat    540

ccacgtggat gaatggaaga gaagactaat taggctgctc ttgtaccatt ctaagcagga    600

ggagaaactt cttaagtctc agcgtaatct cgtggccaag atgaagaaag tcatgcattt    660

acaggatgta gaagtgaaga acgccacaca gtggaaggat aagataaaga gtcagcgaat    720

gagaatcagc acggagtttt caaagctgca caacttcctg gttgaagaag aggacctgtt    780

tcttcagaga ttgaacaaag aagaagaaga gacgaagaag aagctgaatg agaacacgtt    840

aaaactcaat caaactatcg cttcattgaa gaagctcatc ttagaggtgg gggagaagag    900

ccaggctccc accctggagc tgcttcagaa tccaaaagaa gtgttgacca ggagtgagat    960

ccaggatgtg aactattccc ttgaagctgt gaaggtgaag acagtgtgcc agataccatt   1020

gatgaaggaa atgctaaagc gattccaagt ggctgtaaac ctagctgaag acacagctca   1080

tcccaaactc gtcttctccc aggaagggag atacgtgaaa aatacagcat cagccagttc   1140

ttggccagtg ttttcttcag catggaacta ctttgctgga tggaggaatc ctcagaagac   1200

tgcttttgta gagagatttc agcacttacc ctgtgttctg ggaaaaaacg ttttcacctc   1260

agggaaacat tactgggaag ttgagagtag agatagtctg gaggttgctg ttggggtgtg   1320

tcgggaggac gtcatgggaa ttactgatcg ttcaaaaatg tccccagatg tgggcatctg   1380

ggcgatttat tggagtgctg ctggctattg gcccttgata ggcttccctg gaactcccac   1440

ccagcaagag ccagctctcc accgagtggg ggtttacctg gatcgtggga ctgggaatgt   1500

ctccttctac agcgctgtgg acggagtgca cctgcacacc ttttcttgtt cttctgtctc   1560

acgcctccgg ccattttttt ggttgagtcc attagcatct ttagtcattc caccagtgac   1620

tgataggaaa tgaggctttt cttcccctga ccaaaactcc ttccctgtag tccagctgag   1680

ggacacacat ccctgggccc tcttctgccc ttcatgtctc tatcctggat ggtccatctt   1740

ctgggtctcc ctaacggtac cgtttggtat ctgccctttg tgtgcttcac aagaggcagt   1800

cccatgggag gtgggtctgg ccaatggaga tgggacagga aattttccaa gacgcttttg   1860

ggaaatcttt ttgtagcttt taaagagatg tgcggggaag acatatggat gttagcagcc   1920

atattggaac tgagaacaca ggaatggtgg aaaggtagaa gaaacagagt ttttgttgcc   1980

gttgtgaaat tgttgaaatt tccttcatgc caagcttctt gttatatgag ataattacgc   2040

ccttattgta taagacaatt ttagttgtat ttggttactt gcagcctgaa gtaccgtaac   2100

tgcactaaag ggacgtagtg tgaacatccc gcagtatagg cttaagtcac ttttgtgaaa   2160

tttgacaaag gcatagaatc tttttctatc cagtcaggca ttgcctattc tttccagtaa   2220

ctactgattc ccccactttt ctgtcttaga aaattgtggg aatcccccct cactctgcct   2280

atgttgcact ctctctcttc ccaaccataa ctctgccctc agctattaac tgtgctgtgt   2340

atttatcaag ttggtatgtt gtatgtacag tgttattcat gtcatcatga gaatgttgaa   2400

cgcttgttaa ataccttttg ctagcctctt catatgctgt tgcatatgac tctcatcaca   2460

actcagtgag atggaaagac aaatcctatt tgtacaaatg agaaaactga actctttaga   2520

gtaactagct cagtattggc cagctggtaa atggcagtgt tgggattaaa atccagttct   2580

tatctactct ccctttattc agaagcattt attggatgtt gatctttgtt tcaggttttg   2640

attttgttac ttttttatac tgtgtatatt ttcctcagtc tacccttctg ctctagattg   2700

tctggactca ggagattgtg gcagttactg gatagttatt tttaagataa tgattgcttt   2760

tctctgttta tataagtcat gtgtacttat tgtagaaagt ttgtaagatg caaaaagtat   2820

aaaaattaaa gttatgcact actaacattt caatatattt tctcccagat tttcaataaa   2880

gactttcagg cagtgattta acgaggattt tattttaact tatattttag tttaagggga   2940

acacgtgcag gtttgttcta tagatcaatt acatgtcaca ggggtttggt gtacatatta   3000

tttcattacc caggtaataa gcatagtacc caatagatac ttttttgata ccccaccctc   3060

ctccaccctc taccctcaag tagtccctgg tgtctgttgt tccctttttt gtgtccatgg   3120

gtactcaatg tttagctctc ccttatacgt gagaacatgt gatgtttggt tttctgttca   3180

tgtgttggtt tgcttagggt aatggcctcc agctccatcc atgttgctgc aaagacatga   3240

tctcattctt tttttatggc tgcatagtat tccatggtgt atatgtacta tgttttcttt   3300

atccagtcta ctgttgatgg gcatttaggt tgattccatg tctttgctat tgtgaatagt   3360

gctgcaatga atatatacat gcaaaaaaaa aaaaaaaaaa a                       3401


<210>  856
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  856

Met Glu Ala Glu Asp Ile Gln Glu Glu Leu Thr Cys Pro Ile Cys Leu 
1               5                   10                  15      


Asp Tyr Phe Gln Asp Pro Val Ser Ile Glu Cys Gly His Asn Phe Cys 
            20                  25                  30          


Arg Gly Cys Leu His Arg Asn Trp Ala Pro Gly Gly Gly Pro Phe Pro 
        35                  40                  45              


Cys Pro Glu Cys Arg His Pro Ser Ala Pro Ala Ala Leu Arg Pro Asn 
    50                  55                  60                  


Trp Ala Leu Ala Arg Leu Thr Glu Lys Thr Gln Arg Arg Arg Leu Gly 
65                  70                  75                  80  


Pro Val Pro Pro Gly Leu Cys Gly Arg His Trp Glu Pro Leu Arg Leu 
                85                  90                  95      


Phe Cys Glu Asp Asp Gln Arg Pro Val Cys Leu Val Cys Arg Glu Ser 
            100                 105                 110         


Gln Glu His Gln Thr His Ala Met Ala Pro Ile Asp Glu Ala Phe Glu 
        115                 120                 125             


Ser Tyr Arg Thr Gly Asn Phe Asp Ile His Val Asp Glu Trp Lys Arg 
    130                 135                 140                 


Arg Leu Ile Arg Leu Leu Leu Tyr His Ser Lys Gln Glu Glu Lys Leu 
145                 150                 155                 160 


Leu Lys Ser Gln Arg Asn Leu Val Ala Lys Met Lys Lys Val Met His 
                165                 170                 175     


Leu Gln Asp Val Glu Val Lys Asn Ala Thr Gln Trp Lys Asp Lys Ile 
            180                 185                 190         


Lys Ser Gln Arg Met Arg Ile Ser Thr Glu Phe Ser Lys Leu His Asn 
        195                 200                 205             


Phe Leu Val Glu Glu Glu Asp Leu Phe Leu Gln Arg Leu Asn Lys Glu 
    210                 215                 220                 


Glu Glu Glu Thr Lys Lys Lys Leu Asn Glu Asn Thr Leu Lys Leu Asn 
225                 230                 235                 240 


Gln Thr Ile Ala Ser Leu Lys Lys Leu Ile Leu Glu Val Gly Glu Lys 
                245                 250                 255     


Ser Gln Ala Pro Thr Leu Glu Leu Leu Gln Asn Pro Lys Glu Val Leu 
            260                 265                 270         


Thr Arg Ser Glu Ile Gln Asp Val Asn Tyr Ser Leu Glu Ala Val Lys 
        275                 280                 285             


Val Lys Thr Val Cys Gln Ile Pro Leu Met Lys Glu Met Leu Lys Arg 
    290                 295                 300                 


Phe Gln Val Ala Val Asn Leu Ala Glu Asp Thr Ala His Pro Lys Leu 
305                 310                 315                 320 


Val Phe Ser Gln Glu Gly Arg Tyr Val Lys Asn Thr Ala Ser Ala Ser 
                325                 330                 335     


Ser Trp Pro Val Phe Ser Ser Ala Trp Asn Tyr Phe Ala Gly Trp Arg 
            340                 345                 350         


Asn Pro Gln Lys Thr Ala Phe Val Glu Arg Phe Gln His Leu Pro Cys 
        355                 360                 365             


Val Leu Gly Lys Asn Val Phe Thr Ser Gly Lys His Tyr Trp Glu Val 
    370                 375                 380                 


Glu Ser Arg Asp Ser Leu Glu Val Ala Val Gly Val Cys Arg Glu Asp 
385                 390                 395                 400 


Val Met Gly Ile Thr Asp Arg Ser Lys Met Ser Pro Asp Val Gly Ile 
                405                 410                 415     


Trp Ala Ile Tyr Trp Ser Ala Ala Gly Tyr Trp Pro Leu Ile Gly Phe 
            420                 425                 430         


Pro Gly Thr Pro Thr Gln Gln Glu Pro Ala Leu His Arg Val Gly Val 
        435                 440                 445             


Tyr Leu Asp Arg Gly Thr Gly Asn Val Ser Phe Tyr Ser Ala Val Asp 
    450                 455                 460                 


Gly Val His Leu His Thr Phe Ser Cys Ser Ser Val Ser Arg Leu Arg 
465                 470                 475                 480 


Pro Phe Phe Trp Leu Ser Pro Leu Ala Ser Leu Val Ile Pro Pro Val 
                485                 490                 495     


Thr Asp Arg Lys 
            500 


<210>  857
<211>  1247
<212>  DNA
<213>  Homosapiens

<400>  857
gataatatct gtgcctcctg cccagaaccc tccaagcaga cacaatggta agaatggtgc     60

ctgtcctgct gtctctgctg ctgcttctgg gtcctgctgt cccccaggag aaccaagatg    120

gtcgttactc tctgacctat atctacactg ggctgtccaa gcatgttgaa gacgtccccg    180

cgtttcaggc ccttggctca ctcaatgacc tccagttctt tagatacaac agtaaagaca    240

ggaagtctca gcccatggga ctctggagac aggtggaagg aatggaggat tggaagcagg    300

acagccaact tcagaaggcc agggaggaca tctttatgga gaccctgaaa gacatcgtgg    360

agtattacaa cgacagtaac gggtctcacg tattgcaggg aaggtttggt tgtgagatcg    420

agaataacag aagcagcgga gcattctgga aatattacta tgatggaaag gactacattg    480

aattcaacaa agaaatccca gcctgggtcc ccttcgaccc agcagcccag ataaccaagc    540

agaagtggga ggcagaacca gtctacgtgc agcgggccaa ggcttacctg gaggaggagt    600

gccctgcgac tctgcggaaa tacctgaaat acagcaaaaa tatcctggac cggcaagatc    660

ctccctctgt ggtggtcacc agccaccagg ccccaggaga aaagaagaaa ctgaagtgcc    720

tggcctacga cttctaccca gggaaaattg atgtgcactg gactcgggcc ggcgaggtgc    780

aggagcctga gttacgggga gatgttcttc acaatggaaa tggcacttac cagtcctggg    840

tggtggtggc agtgcccccg caggacacag ccccctactc ctgccacgtg cagcacagca    900

gcctggccca gcccctcgtg gtgccctggg aggccagcta ggaagcaagg gttggaggca    960

atgtgggatc tcagacccag tagctgccct tcctgcctga tgtgggagct gaaccacaga   1020

aatcacagtc aatggatcca caaggcctga ggagcagtgt ggggggacag acaggaggtg   1080

gatttggaga ccgaagactg ggatgcctgt cttgagtaga cttggaccca aaaaatcatc   1140

tcaccttgag cccaccccca ccccattgtc taatctgtag aagctaataa ataatcatcc   1200

ctccttgcct agcataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 1247


<210>  858
<211>  298
<212>  PRT
<213>  Homosapiens

<400>  858

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  859
<211>  2146
<212>  DNA
<213>  Homosapiens

<400>  859
agacacaatg gtaagaatgg tgtctgtcct gctgtctctg ctgctgcttc tgggtcctgc     60

tgtcctccag gagacccgag atggtcatta ctctctgacc tatctctaca ctgggctgtc    120

caggtctggc aaaggcaccc acaggctgca gggcactgtc ttcctcaatg gccatgcctt    180

cttccactac aacagtgaag acaggaaggc tgagcccctg ggaccatgga gacatgcgga    240

aggagtagag gactgggaga agcagagcca agttcagaag gccagggagg acatctttat    300

ggagaccctg aacaacatca tggagtatta caacgacggt aacggatgtg tggcaggttc    360

ctgaggtggt ggctgctggc ggaggagagc tggcactcca cccccgtggg gcgcctcctg    420

tttcccgtgc tcctgggatt ccgccttgtg ctgctggctg ccagtgggcc tggagtctat    480

ggcgatgagc agagtgaatt cgtgtgtcac acccagcagc cgggctgcaa ggctgcctgc    540

ttcgatgcct tccacccgct ctccccgctg cgtttctggg tcttccaggt catcttggtg    600

gctgtaccta gcgtcctcta catgggtttc actctgtatc acgtgatctg gcactgggaa    660

gaatcatgaa aggggacgga ggaagaggac accctgatcc agggagggga gagcagcaga    720

gataccccag gggctggaag cctcaggctg ctctgagctt atgtggctca gctgggagct    780

cagctggtcc tggaggggac agcgccgggg ttgcagtacc acctgtatgg gttccagatg    840

cccagctcct ttgcatgtgg ccaagagcct tgcccgtata gattaacttg caccttttcc    900

cacccctcgg agaagatcat ctttctaaaa gccatgtttg gggtcagtgg gttccgtctc    960

ttgttcactc ttttggagat tgtgcttctg ggtctgggaa gactgtgtaa gcccctgcgg   1020

aacttcctgg gtggggcctc ttcctccagc cacgccctgg ccctgagcag caaaaggaac   1080

ctccagcaga cactgtgagc catccatcgg cctggtcagc cttgttccat ttcagagacc   1140

atgttcccca cagccccagt gactaggggt gacatctcct gacctccccc acctgtggat   1200

atggccaagt cgaggtaccg gttaaccaaa gatgctgaag gagtgaagaa ccagccatcc   1260

cctaatacgc aggatggtta tattgattat gtcaaactga aaactttgga gaaactcctc   1320

tctcagaaag cgataactgg gccagacacg gtggctcatg cctgtaatcc cagcattttg   1380

ggaggcctag gcaggtggat cacttgaggt caggagttca agaccagcca ggccaacatg   1440

gtgaaacccg tgtctactaa aactacaaaa attctgggca tggtggtggg cgtctgtaat   1500

cccagctact tgagaggctg aggcaggaga attgcttgaa cctgggaggt ggaggttgca   1560

aagagccgag atcatgccac tgcactccag cctgggtgac tccgtctcaa aaaaaaaaaa   1620

aaaaaaaaaa agtgctggtg ttccttagga ctgtgttgcg ggccctctct ctccccattc   1680

cacaccctca ctctccctgg ataactttcc ctttgtctat agctccagcc accacgtcct   1740

tgcggatgac ttcccagtgc agatccccag tctgggctac ctctcgagtt caggcttgaa   1800

atcctgtcgt tcggccaggc acggtggctc acgctgtaat atcagccctc tgggggtcga   1860

ggcgggcaga tcacctgagg tcaagtgtct gagaccagtc tggccaacat gcgagacccc   1920

ccatctctaa aaaataaaat aaagtacata taccagcaat gatgtataac cgaaaaataa   1980

ataaataaac aagttaatat tgaaatgtca tgtttgcccc caacccaaat aagcactata   2040

acctcttgtt attcacttct catgcaacca gtcttctgtt ctctgtgagt ctttaggaaa   2100

tgaggagcat gatcttctag cagtaaaaca cctgtagaga attgcc                  2146


<210>  860
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  860

Met Val Ser Val Leu Leu Ser Leu Leu Leu Leu Leu Gly Pro Ala Val 
1               5                   10                  15      


Leu Gln Glu Thr Arg Asp Gly His Tyr Ser Leu Thr Tyr Leu Tyr Thr 
            20                  25                  30          


Gly Leu Ser Arg Ser Gly Lys Gly Thr His Arg Leu Gln Gly Thr Val 
        35                  40                  45              


Phe Leu Asn Gly His Ala Phe Phe His Tyr Asn Ser Glu Asp Arg Lys 
    50                  55                  60                  


Ala Glu Pro Leu Gly Pro Trp Arg His Ala Glu Gly Val Glu Asp Trp 
65                  70                  75                  80  


Glu Lys Gln Ser Gln Val Gln Lys Ala Arg Glu Asp Ile Phe Met Glu 
                85                  90                  95      


Thr Leu Asn Asn Ile Met Glu Tyr Tyr Asn Asp Gly Asn Gly Cys Val 
            100                 105                 110         


Ala Gly Ser 
        115 


<210>  861
<211>  5494
<212>  DNA
<213>  Homosapiens

<400>  861
gtgactcatt gtgtctgtgt cgaggcgtcg ggagggccta agtccgtgtg cggtgccctt     60

cggccggcct gagccccaga gtcagctccc ctttctcgcc cagcgccccc aggccgctcc    120

cggggctcac ggaatagtaa agaaacacat cataaaacct cccaggacat aaaggtgagc    180

acagaccctg tttggatcaa gtcagttcct ggagcctgaa tgatgactgc tgaatcacgg    240

gaagccacgg gtctgtcccc acaggctgca caggagaagg atggtatcgt aatagtgaag    300

gtggaagagg aagatgagga agaccacatg tgggggcagg attccaccct acaggacacg    360

cctcctccag acccagagat attccgccaa cgcttcaggc gcttctgtta ccagaacact    420

tttgggcccc gagaggctct cagtcggctg aaggaacttt gtcatcagtg gctgcggcca    480

gaaataaaca ccaaggaaca gatcctggag cttctggtgc tagagcagtt tctttccatc    540

ctgcccaagg agctccaggt ctggctgcag gaataccgcc ccgatagtgg agaggaggcc    600

gtgacccttc tagaagactt ggagcttgat ttatcaggac aacaggtccc aggtcaagtt    660

catggacctg agatgctcgc aagggggatg gtgcctctgg atccagttca ggagtcctcg    720

agctttgacc ttcatcacga ggccacccag tcccacttca aacattcgtc tcggaaaccc    780

cgcctcttac agtcacgagc tcttcctgct gcccacattc ctgcaccccc tcatgagggt    840

agtcccagag accaggcgat ggcatctgca ctattcacag cggattccca ggcaatggtg    900

aagatcgagg acatggctgt gtccctcatt ctggaggaat ggggatgtca gaatctggct    960

cggaggaatc tcagtaggga caacaggcag gagaattatg ggagcgcatt tccccagggt   1020

ggtgaaaaca ggaatgagaa cgaggagtca acctcaaagg ctgaaacctc ggaagattca   1080

gcatcacgcg gggagacaac aggaagatcc cagaaagagt ttggagagaa acgtgaccag   1140

gagggcaaaa caggagaaag acagcagaaa aaccctgagg agaaaaccag gaaagagaaa   1200

agagattcag ggccagctat aggaaaggac aaaaaaacca tcacaggaga gagaggtcca   1260

agggagaagg ggaaaggatt gggaagaagc ttcagtctga gctccaactt caccacccct   1320

gaagaagttc ccacgggaac aaagtctcac agatgtgatg aatgtggtaa atgcttcacg   1380

agaagttcaa gccttatccg ccataaaata atccacactg gagaaaagcc ctatgaatgt   1440

agtgagtgtg ggaaagcctt cagtcttaac tccaaccttg tcctgcatca gaggatccac   1500

acaggagaga aacctcatga atgtaacgag tgtggcaagg ccttcagcca cagttccaat   1560

ctcatcctcc atcagcgcat ccactctgga gagaaacctt atgaatgtaa tgagtgcggg   1620

aaggccttca gccagagctc ggacctcacc aagcatcaga gaattcacac gggggagaaa   1680

ccctatgaat gtagtgaatg tggaaaagct ttcaaccgaa actcatacct gattttgcat   1740

cggagaattc acactcgaga aaagccctac aagtgcacta agtgtggcaa ggccttcacc   1800

cgcagctcca ccctcactct gcatcacaga atccatgcca gagagagagc ctctgagtac   1860

agcccagcct cccttgatgc atttggcgcg ttcctgaaaa gttgtgtgta aaggaagaat   1920

ttgccatcaa gccatttccc ccttttgttt ctaaaattat ttcagagatg tgtgctcctg   1980

gagggaaaaa gaaatacagc ctcaacagat taaaaaacaa aagtcacact taaggatcct   2040

tctagtcaca tcagcagtgt tctgccttta tgtagtagtt gggcatataa tccttccaca   2100

cagcccctgc agggaaaggc taatcttacg gataatccac gtgagatttc cacacaagag   2160

aaaagcacac gcatagtgaa atgtcagtct tttcagtaat gaggatacct ttaaggcact   2220

cttggactct cggcaaccac aacataatag ttgaaagatc aagattggct ccacgaaagt   2280

gatacggagg ttaggatgct acttgctgca aacaagccct actttggcca acatcctgct   2340

tatttctcaa aaaagaggga cagtgaaaac aaaaacgaca ttgggacatg ctgctcaagg   2400

tagttatata tacgataagt tgtatatatg atcactggta gcctaccaaa gctgtagaaa   2460

tctaggactg tgctaatcag tatcaaacca aagatttcta tctcttcccg aaagagaggg   2520

tatgtgcacc agtctacagt tccaaaggac tgcaacaaat gtagatggtt ctgtcctcat   2580

ccctgagatc agttctactg aaatggcaac aacaactcca aatacatctc tcccttcttg   2640

aaatccctaa agcactatcg cactcctaaa tgcatttctc cacaagttag cacttgattg   2700

tatactgtct tttaatcctt cattgtttca tgtatgaagt ttttaatcac cccctaaccc   2760

ccaaaaaaga ttcggttgtc aagggatata tttctatccc tgccagcaca gtgctggaca   2820

tagtgagtac tgaacaccta agaggcactc attcagactg acttctacag gacttctacg   2880

tgtgtgataa aagcctgtga atcgtgagtc cctgaaatat ggtagcctgg cccagcttct   2940

aaagaggacc ttcgtagcca caaggcatgc taaacctcta gggtctgatg ctgtttttgt   3000

tccaaatata aacgaaaggc actagtcagc cgcctgcata gactttctaa acagtgagta   3060

aataccatgg aatgtcagaa atgactttat catcgtcatc ttgaagaaaa atatgaacac   3120

tgatgaaggt catttttttt ttttgacatc tttctgtggc aaagctctta gaattctttg   3180

cagttagctg ctgaacagta tgatgatttg gggattttct gaatcatttg tacttagata   3240

ctggagttca gaagatgtga tttttgttgc ttttcagaaa aaggaacgtg gtagggagtg   3300

ttttttccca cgcttttcca gtaactttgc aaaagcatta attgttcact ggcaattact   3360

aaatgtattt tgttgctctg agaaactcag cagtgtactg agatgtggct ggctgtgcca   3420

tcgtcatagt gcacagtgac ttttctgttt cttatcacta aagactgagg tgaggttatg   3480

aaactttcat tggtcccatc gttgtgcgca gggtgcaact ggctacctag aagctgatgg   3540

caggagactg tttcacacac aggagattgt gagctgtgta agtagtcatc gccactcaag   3600

taggacaagg gtcctaccca aggctaggac cgccctgcgg aaacagaaac atagactgag   3660

aacaaacctc aagactatca gtgtgacctc cccataacaa gagaacccca tatatagttt   3720

gagactttcc cttgagaaac ttatactaaa actattactc atcagtcatt cactgatcag   3780

cagctaaagt ccatgagacc aaatggtttt atatggaacc aacgaagtgg gagctaaaac   3840

tgcacagtgg tcattctttg gcctctcctt ggctttatga cttaaaccaa ctacaacttc   3900

cctatagctt ctaagcagtt tcatcagcat tacttgggaa aacgtgttgc aagtcaacca   3960

gtcactagga tatttctacc catgcaacgg aagaaaaacc cattactcca gaagagtata   4020

tctaagtaac taaaatggag gcagaaaatg ttttaaggat tttcttcaaa gaataagcca   4080

cagcaatggt tttgtagaaa actcctgtgc ttttgagcaa ggacttttgc cctctagaaa   4140

gcaactgagg ccaggtgcgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg   4200

tgagcggatc acctgaggtc aggagttttg agaccagcct ggccaacatg gtaaaatccc   4260

gtctctacta aaattataaa aattagccgg gcatgatggt gggcacctgt aatcccagct   4320

acttgggagg ctgaggcagg agaatcactt gaacccagga ggcagaggtt gcagtgagcc   4380

aagattgcac actgcactcc agcctgggtg actagcaaaa ctccatctca aaaaaaaaaa   4440

aaagaaagaa agaaactgaa aagtgaggtg tggaactcca ggcaacgacc caagcactta   4500

ttttttaaga gggaaaggac tttggtcatg tttacattgg cctttggttt ttttttttct   4560

ttcagccaca actatatgct gatataactc agccatcact tttgagtttt gtttttaaat   4620

gaaggttaaa tgtgacctgt gccctcacat ttaattccgt ttcatggaga catcttcctg   4680

actttgttgg atagctgcca ctagggttgc ttcgatcttc agccacatgc tgtccttgaa   4740

gcagctattt gaagatgtgt tttctgagga aaacaggcta caactgttta ttaaaaccac   4800

ttgcagtgca ttcgtttatc agatgctcag tgcaaagtgt aattgggtca tggtcaaaaa   4860

cgcttgcaac atctaattgg cgttcaagat agtcattcaa aagttcttgg cccgctgaag   4920

tctgttaaca gttgaaacat tctacagtta accattagca tgctagttgt cctaatggaa   4980

atttttgaag agtttttcaa tatataccct acccttgcca ggaagagaag taaaatcctc   5040

aggttgtggg gtatttgttt ctactccagc ctggcaggca aggctaaaac ctgagattat   5100

cgatctatga gacatcttga tatgtaaagc acttaatatt aaaggcataa aagtgaaact   5160

gctaaatatg tatagagagg ttgacgtgtg atacgtggga cagttcacat agacatcaga   5220

gaatttattc cagaaaggag cctcctgaat gtgatgaata cggcaaagcc tttaatcaca   5280

tctcagccct tagcatcgga aagcttatac tgtaaataaa cttgatgaat attatatgtg   5340

aggaaaactt tcatgtatag cactcattgc ttcagacaga aaatgaattc cgtcggtatg   5400

ttccaatcgt gatgaatttg agaaacattg caagagggag ctcaatcttg gccgggcgcc   5460

gtggctcacg cctgtaatcg cagcactttg ggag                               5494


<210>  862
<211>  563
<212>  PRT
<213>  Homosapiens

<400>  862

Met Met Thr Ala Glu Ser Arg Glu Ala Thr Gly Leu Ser Pro Gln Ala 
1               5                   10                  15      


Ala Gln Glu Lys Asp Gly Ile Val Ile Val Lys Val Glu Glu Glu Asp 
            20                  25                  30          


Glu Glu Asp His Met Trp Gly Gln Asp Ser Thr Leu Gln Asp Thr Pro 
        35                  40                  45              


Pro Pro Asp Pro Glu Ile Phe Arg Gln Arg Phe Arg Arg Phe Cys Tyr 
    50                  55                  60                  


Gln Asn Thr Phe Gly Pro Arg Glu Ala Leu Ser Arg Leu Lys Glu Leu 
65                  70                  75                  80  


Cys His Gln Trp Leu Arg Pro Glu Ile Asn Thr Lys Glu Gln Ile Leu 
                85                  90                  95      


Glu Leu Leu Val Leu Glu Gln Phe Leu Ser Ile Leu Pro Lys Glu Leu 
            100                 105                 110         


Gln Val Trp Leu Gln Glu Tyr Arg Pro Asp Ser Gly Glu Glu Ala Val 
        115                 120                 125             


Thr Leu Leu Glu Asp Leu Glu Leu Asp Leu Ser Gly Gln Gln Val Pro 
    130                 135                 140                 


Gly Gln Val His Gly Pro Glu Met Leu Ala Arg Gly Met Val Pro Leu 
145                 150                 155                 160 


Asp Pro Val Gln Glu Ser Ser Ser Phe Asp Leu His His Glu Ala Thr 
                165                 170                 175     


Gln Ser His Phe Lys His Ser Ser Arg Lys Pro Arg Leu Leu Gln Ser 
            180                 185                 190         


Arg Ala Leu Pro Ala Ala His Ile Pro Ala Pro Pro His Glu Gly Ser 
        195                 200                 205             


Pro Arg Asp Gln Ala Met Ala Ser Ala Leu Phe Thr Ala Asp Ser Gln 
    210                 215                 220                 


Ala Met Val Lys Ile Glu Asp Met Ala Val Ser Leu Ile Leu Glu Glu 
225                 230                 235                 240 


Trp Gly Cys Gln Asn Leu Ala Arg Arg Asn Leu Ser Arg Asp Asn Arg 
                245                 250                 255     


Gln Glu Asn Tyr Gly Ser Ala Phe Pro Gln Gly Gly Glu Asn Arg Asn 
            260                 265                 270         


Glu Asn Glu Glu Ser Thr Ser Lys Ala Glu Thr Ser Glu Asp Ser Ala 
        275                 280                 285             


Ser Arg Gly Glu Thr Thr Gly Arg Ser Gln Lys Glu Phe Gly Glu Lys 
    290                 295                 300                 


Arg Asp Gln Glu Gly Lys Thr Gly Glu Arg Gln Gln Lys Asn Pro Glu 
305                 310                 315                 320 


Glu Lys Thr Arg Lys Glu Lys Arg Asp Ser Gly Pro Ala Ile Gly Lys 
                325                 330                 335     


Asp Lys Lys Thr Ile Thr Gly Glu Arg Gly Pro Arg Glu Lys Gly Lys 
            340                 345                 350         


Gly Leu Gly Arg Ser Phe Ser Leu Ser Ser Asn Phe Thr Thr Pro Glu 
        355                 360                 365             


Glu Val Pro Thr Gly Thr Lys Ser His Arg Cys Asp Glu Cys Gly Lys 
    370                 375                 380                 


Cys Phe Thr Arg Ser Ser Ser Leu Ile Arg His Lys Ile Ile His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Leu 
                405                 410                 415     


Asn Ser Asn Leu Val Leu His Gln Arg Ile His Thr Gly Glu Lys Pro 
            420                 425                 430         


His Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser His Ser Ser Asn Leu 
        435                 440                 445             


Ile Leu His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Asn 
    450                 455                 460                 


Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Asp Leu Thr Lys His Gln 
465                 470                 475                 480 


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys 
                485                 490                 495     


Ala Phe Asn Arg Asn Ser Tyr Leu Ile Leu His Arg Arg Ile His Thr 
            500                 505                 510         


Arg Glu Lys Pro Tyr Lys Cys Thr Lys Cys Gly Lys Ala Phe Thr Arg 
        515                 520                 525             


Ser Ser Thr Leu Thr Leu His His Arg Ile His Ala Arg Glu Arg Ala 
    530                 535                 540                 


Ser Glu Tyr Ser Pro Ala Ser Leu Asp Ala Phe Gly Ala Phe Leu Lys 
545                 550                 555                 560 


Ser Cys Val 
            


<210>  863
<211>  1416
<212>  DNA
<213>  Homosapiens

<400>  863
acgggctatt taaaggtacg cgccgcggcc aaggccgcac cgtactgggc gggggtctgg     60

ggagcgcagc agccatggca agccgtctcc tgctcaacaa cggcgccaag atgcccatcc    120

tggggttggg tacctggaag tcccctccag ggcaggtgac tgaggccgtg aaggtggcca    180

ttgacgtcgg gtaccgccac atcgactgtg cccatgtgta ccagaatgag aatgaggtgg    240

gggtggccat tcaggagaag ctcagggagc aggtggtgaa gcgtgaggag ctcttcatcg    300

tcagcaagct gtggtgcacg taccatgaga agggcctggt gaaaggagcc tgccagaaga    360

cactcagcga cctgaagctg gactacctgg acctctacct tattcactgg ccgactggct    420

ttaagcctgg gaaggaattt ttcccattgg atgagtcggg caatgtggtt cccagtgaca    480

ccaacattct ggacacgtgg gcggccatgg aagagctggt ggatgaaggg ctggtgaaag    540

ctattggcat ctccaacttc aaccatctcc aggtggagat gatcttaaac aaacctggct    600

tgaagtataa gcctgcagtt aaccagattg agtgccaccc atatctcact caggagaagt    660

taatccagta ctgccagtcc aaaggcatcg tggtgaccgc ctacagcccc ctcggctctc    720

ctgacaggcc ctgggccaag cccgaggacc cttctctcct ggaggatccc aggatcaagg    780

cgatcgcagc caagcacaat aaaactacag cccaggtcct gatccggttc cccatgcaga    840

ggaacttggt ggtgatcccc aagtctgtga caccagaacg cattgctgag aactttaagg    900

tctttgactt tgaactgagc agccaggata tgaccacctt actcagctac aacaggaact    960

ggagggtctg tgccttgttg agctgtacct cccacaagga ttaccccttc catgaagagt   1020

tttgaagctg tggttgcctg ctcgtcccca agtgacctat acctgtgttt cttgcctcat   1080

ttttttcctt gcaaatgtag tatggcctgt gtcactcagc agtgggacag caacctgtag   1140

agtggccagc gagggcgtgt ctagcttgat gttggatctc aagagccctg tcagtagagt   1200

agaagtctct tccagtttgc tttgcccttc tttctaccct gctggggaaa gtacaacctg   1260

aatacccttt tctgaccaaa gagaagcaaa atctaccagg tcaaaatagt gccactaacg   1320

gttgagtttt gactgcttgg aactggaatc ctttcagcaa gacttctctt tgcctcaaat   1380

aaaaagtgct tttgtgagaa aaaaaaaaaa aaaaaa                             1416


<210>  864
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  864

Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 
        35                  40                  45              


Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 
    50                  55                  60                  


Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Cys Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr 
                85                  90                  95      


Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser 
        115                 120                 125             


Gly Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 
145                 150                 155                 160 


Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys 
225                 230                 235                 240 


His Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg 
                245                 250                 255     


Asn Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu 
            260                 265                 270         


Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr 
        275                 280                 285             


Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys 
    290                 295                 300                 


Thr Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
305                 310                 315     


<210>  865
<211>  1551
<212>  DNA
<213>  Homosapiens

<400>  865
cctgagctca ggagtttgag accagcctgt ctctactaac aatataaaaa ttagctggga     60

gtcacggtgg gcgcctgtaa tcccagctac tcgggaggct gaggcaggag aattgcttga    120

acccaggaga cagaggttgt agtgagctga gatcgcacca ctgcactcta gccttggcaa    180

cagtgcaaga ctgtctcaaa aacagcaaca gagagcagga cgtgagactt ctacctgctc    240

actcagaatc atttctgcac caaccatggc cacgtttgtg gagctcagta ccaaagccaa    300

gatgcccatt gtgggcctgg gcacttggaa gtctcctctt ggcaaagtga aagaagcagt    360

gaaggtggcc attgatgcag gatatcggca cattgactgt gcctatgtct atcagaatga    420

acatgaagtg ggggaagcca tccaagagaa gatccaagag aaggctgtga agcgggagga    480

cctgttcatc gtcagcaagt tgtggcccac tttctttgag agaccccttg tgaggaaagc    540

ctttgagaag accctcaagg acctgaagct gagctatctg gacgtctatc ttattcactg    600

gccacaggga ttcaagtctg gggatgacct tttccccaaa gatgataaag gtaatgccat    660

cggtggaaaa gcaacgttct tggatgcctg ggaggccatg gaggagctgg tggatgaggg    720

gctggtgaaa gcccttgggg tctccaattt cagccacttc cagatcgaga agctcttgaa    780

caaacctgga ctgaaatata aaccagtgac taaccaggtt gagtgtcacc catacctcac    840

acaggagaaa ctgatccagt actgccactc caagggcatc accgttacgg cctacagccc    900

cctgggctct ccggatagac cttgggccaa gccagaagac ccttccctgc tggaggatcc    960

caagattaag gagattgctg caaagcacaa aaaaaccgca gcccaggttc tgatccgttt   1020

ccatatccag aggaatgtga ttgtcatccc caagtctgtg acaccagcac gcattgttga   1080

gaacattcag gtctttgact ttaaattgag tgatgaggag atggcaacca tactcagctt   1140

caacagaaac tggagggcct gtaacgtgtt gcaatcctct catttggaag actatccctt   1200

cgatgcagaa tattgaggtt gaatctcctg gtgagattat acaggagatt ctctttcttc   1260

gctgaagtgt gactacctcc actcatgtcc cattttagcc aagcttattt aagatcacag   1320

tgaacttagt cctgttatag acgagaatcg aggtgctgtt ttagacattt atttctgtat   1380

gttcaactag gatcagaata tcacagaaaa gcatggcttg aataaggaaa tgacaatttt   1440

ttccacttat ctgatcagaa caaatgttta ttaagcatca gaaactctgc caacactgag   1500

gatgtaaaga tcaataaaaa aaataataat cataaaaaaa aaaaaaaaaa a            1551


<210>  866
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  866

Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 
                85                  90                  95      


Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 
        115                 120                 125             


Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 
    290                 295                 300                 


Ser His Leu Glu Asp Tyr Pro Phe Asp Ala Glu Tyr 
305                 310                 315     


<210>  867
<211>  1334
<212>  DNA
<213>  Homosapiens

<400>  867
tccgggcttc cccagacaga cagctggctt acagggccac ctgaagacgt tccagggctc     60

cacaggccac tgtcttctgg aggggaacgg atcgactgcc ggtgcgccca gccaaattca    120

actcctgagt cctcagtctc tagtcccggg aaggtttcac cgagctgccc tactccttgt    180

accccttcta gctggcctta gcatagctac gtcagcagct attggcacga ctgccctgat    240

tcaaggagaa actggactaa tatcactatc tcaacaggat cgaggccatc aagctacaga    300

tggtcttaca aatggaaccc caagtgaact caactaacaa cttccaccaa ggacccctgg    360

accaacccgt tggccctttg actggcctaa agagttccct tctgaaggac actacaagtg    420

cagggcccct tcttcgcccc tatccagcat ctcttctcgg caaagtgaaa gaagcggtga    480

aggtggccat tgatgcagaa tatcgccaca ttgactgtgc ctatttctat gagaatcaac    540

atgaggtggg agaagccatc caagagaaga tccaagagaa ggctgtgatg cgggaggacc    600

tgttcatcgt cagcaaggtg tggcccactt tctttgagag accccttgtg aggaaagcct    660

ttgagaagac cctcaaggac ctgaagctga gctatctgga cgtctatctt attcactggc    720

cacagggatt caagactggg gatgactttt tccccaaaga tgataaaggt aatatgatca    780

gtggaaaagg aacgttcttg gatgcctggg aggccatgga ggagctggtg gacgaggggc    840

tggtgaaagc ccttggggtc tcaaatttca accacttcca gatcgagagg ctcttgaaca    900

aacctggact gaaatataaa ccagtgacta accaggttga gtgtcaccca tacctcacgc    960

aggagaaact gatccagtac tgccactcca agggcatcac cgttacggcc tacagccccc   1020

tgggctctcc ggatagacct tgggccaaac ctgaggaccc ttccctgctg gaggatccca   1080

agattaagga gattgctgca aagcacaaaa aaaccacagc ccaggttctg atccgtttcc   1140

atatccagag gaatgtgaca gtgatcccca agtctatgac accagcacac attgttgaga   1200

acattcaggt ctttgacttt aaattgagtg atgaggagat ggcaaccata ctcagcttca   1260

acagaaactg gagggccttt gacttcaagg aattctctca tttggaggac tttcccttcg   1320

atgcagaata ttga                                                     1334


<210>  868
<211>  344
<212>  PRT
<213>  Homosapiens

<400>  868

Met Val Leu Gln Met Glu Pro Gln Val Asn Ser Thr Asn Asn Phe His 
1               5                   10                  15      


Gln Gly Pro Leu Asp Gln Pro Val Gly Pro Leu Thr Gly Leu Lys Ser 
            20                  25                  30          


Ser Leu Leu Lys Asp Thr Thr Ser Ala Gly Pro Leu Leu Arg Pro Tyr 
        35                  40                  45              


Pro Ala Ser Leu Leu Gly Lys Val Lys Glu Ala Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Ala Glu Tyr Arg His Ile Asp Cys Ala Tyr Phe Tyr Glu Asn Gln 
65                  70                  75                  80  


His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln Glu Lys Ala Val 
                85                  90                  95      


Met Arg Glu Asp Leu Phe Ile Val Ser Lys Val Trp Pro Thr Phe Phe 
            100                 105                 110         


Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr Leu Lys Asp Leu 
        115                 120                 125             


Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp Pro Gln Gly Phe 
    130                 135                 140                 


Lys Thr Gly Asp Asp Phe Phe Pro Lys Asp Asp Lys Gly Asn Met Ile 
145                 150                 155                 160 


Ser Gly Lys Gly Thr Phe Leu Asp Ala Trp Glu Ala Met Glu Glu Leu 
                165                 170                 175     


Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser Asn Phe Asn His 
            180                 185                 190         


Phe Gln Ile Glu Arg Leu Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro 
        195                 200                 205             


Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr Gln Glu Lys Leu 
    210                 215                 220                 


Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr Ala Tyr Ser Pro 
225                 230                 235                 240 


Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu Asp Pro Ser Leu 
                245                 250                 255     


Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys His Lys Lys Thr 
            260                 265                 270         


Thr Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg Asn Val Thr Val 
        275                 280                 285             


Ile Pro Lys Ser Met Thr Pro Ala His Ile Val Glu Asn Ile Gln Val 
    290                 295                 300                 


Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr Ile Leu Ser Phe 
305                 310                 315                 320 


Asn Arg Asn Trp Arg Ala Phe Asp Phe Lys Glu Phe Ser His Leu Glu 
                325                 330                 335     


Asp Phe Pro Phe Asp Ala Glu Tyr 
            340                 


<210>  869
<211>  1769
<212>  DNA
<213>  Homosapiens

<400>  869
gcccacgtct ggttcagggg ctagaaaaga gcgtcgatgc cggcggcagt gatgagtcct     60

aggaggcgct ggctctttgg cggctcggag gagcggctgc tgctgctgct gctgctgctg    120

gtggcccctt tgcagatgta ttgctgtcct tgaatattag cccatttgaa aacgcctggg    180

aagttcagcc atcagtatgt ccaagtacaa acttattatg ttaagacatg gagagggtgc    240

ttggaataag gagaaccgtt tttgtagctg ggtggatcag aaactcaaca gcgaaggaat    300

ggaggaagct cggaactgtg ggaagcaact caaagcgtta aactttgagt ttgatcttgt    360

attcacatct gtccttaatc ggtccattca cacagcctgg ctgatcctgg aagagctagg    420

ccaggaatgg gtgcctgtgg aaagctcctg gcgtctaaat gagcgtcact atggggcctt    480

gatcggtctc aacagggagc agatggcttt gaatcatggt gaagaacaag tgaggctctg    540

gagaagaagc tacaatgtaa ccccgcctcc cattgaggag tctcatcctt actaccaaga    600

aatctacaac gaccggaggt ataaagtatg cgatgtgccc ttggatcaac tgccacggtc    660

ggaaagctta aaggatgttc tggagagact ccttccctat tggaatgaaa ggattgctcc    720

cgaagtatta cgtggcaaaa ccattctgat atctgctcat ggaaatagca gtagggcact    780

cctaaaacac ctggaaggta tctcagatga agacatcatc aacattactc ttcctactgg    840

agtccccatt cttctggaat tggatgaaaa cctgcgtgct gttgggcctc atcagttcct    900

gggtgaccaa gaggcgatcc aagcagccat taagaaagta gaagatcaag gaaaagtgaa    960

acaagctaaa aaatagtctt tctcaactgt tggctaagaa gaaatgcaaa agaagtggca   1020

taggagtgtg ttatgggtgc tgaactctct ctctttttcc ccgattttcc agagctaggc   1080

tgtggagtag agtttgtata ggtaactagg taacttattg tggcccagat aaggctttag   1140

gatgcctcag tgcttatgtc atagccttat gagttagctt tcttgctagc cccctagtcg   1200

gtcaccaaac tagtaactag tggggcttaa tgaaggtcat aagtttctga gatgggagag   1260

caacaagtag agatgaagtt aaaggtattt atcattcaag aaatcattat tgagtcacca   1320

ttgacaggca ctattctaat cagtagttca ctttaatatt taataagatt ttctgggata   1380

acagtaaggg atattagata atataccgta tgtatttatt actagtcttt tcctctagga   1440

aaagggatac tttgataatt aaggccagag gcccattagt tgagaaagtc acagatatat   1500

ttctccaaga aagccaacaa ccaccaccac aatgacagaa atgacaacaa ggccctttaa   1560

cttgtcttct agtttagaga catccttcat ttgacattta gtagaattcc tctttggcca   1620

caagaataag cagcaaataa acaactatgg ctgttgaggt tctcattttg gtttgtttta   1680

attttttgaa ctttgggtac ctgtaattag tttaaaaata aagttcctga taataaagtg   1740

actgaaaatg gcatccccaa aaaaaaaaa                                     1769


<210>  870
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  870

Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp 
1               5                   10                  15      


Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser 
            20                  25                  30          


Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu 
        35                  40                  45              


Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile 
    50                  55                  60                  


His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro 
65                  70                  75                  80  


Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile 
                85                  90                  95      


Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val 
            100                 105                 110         


Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu 
        115                 120                 125             


Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val 
    130                 135                 140                 


Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp 
145                 150                 155                 160 


Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu 
                165                 170                 175     


Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser 
            180                 185                 190         


Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile 
        195                 200                 205             


Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu 
    210                 215                 220                 


Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala 
225                 230                 235                 240 


Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln 
                245                 250                 255     


Ala Lys Lys 
            


<210>  871
<211>  2074
<212>  DNA
<213>  Homosapiens

<400>  871
ggggctagaa aagagcgtcg atgccggcgg cagtgatgag ccctagcacg cgtccgctct     60

ttggcggctc ggaggagcgg ctgctgctgc tgctgctgct gctggtggcc cctttgcaga    120

aaagttctaa gaacagtgct gttggctcag tgagatgagg ttatcggaaa actttctgtt    180

tacacaagag ttgcctcctt caaagaagca tgcatggtcc ttgcaggtca ctgtgcccat    240

cactctgcat agtccagctg cactctgctt cacacagctg cctgcccatt gcaggcattt    300

gagtttgcaa tccatgcctt aaactttaaa tcacactggc tacagcgttg tgtgtttctt    360

ggtaaacact gggtaaatca gctcctgtgg atgttgactg aagtttctat gtttgcaagc    420

taatcctcag cagtttcttt atgtattgct gtccttgaat attagcccat ttgaaaacgc    480

ctgggaagtt cagccatcag tatgtccaag tacaaactta ttatgttaag acatggagag    540

ggtgcttgga ataaggagaa ccgtttttgt agctgggtgg atcagaaact caacagcgaa    600

ggaatggagg aagctcggaa ctgtgggaag caactcaaag cgttaaactt tgagtttgat    660

cttgtattca catctgtcct taatcggtcc attcacacag cctggctgat cctggaagag    720

ctaggccagg aatgggtgcc tgtggaaagc tcctggcgtc taaatgagcg tcactatggg    780

gccttgatcg gtctcaacag ggagcagatg gctttgaatc atggtgaaga acaagtgagg    840

ctctggagaa gaagctacaa tgtaaccccg cctcccattg aggagtctca tccttactac    900

caagaaatct acaacgaccg gaggtataaa gtatgcgatg tgcccttgga tcaactgcca    960

cggtcggaaa gcttaaagga tgttctggag agactccttc cctattggaa tgaaaggatt   1020

gctcccgaag tattacgtgg caaaaccatt ctgatatctg ctcatggaaa tagcagtagg   1080

gcactcctaa aacacctgga aggtatctca gatgaagaca tcatcaacat tactcttcct   1140

actggagtcc ccattcttct ggaattggat gaaaacctgc gtgctgttgg gcctcatcag   1200

ttcctgggtg accaagaggc gatccaagca gccattaaga aagtagaaga tcaaggaaaa   1260

gtgaaacaag ctaaaaaata gtctttctca actgttggct aagaagaaat gcaaaagaag   1320

tggcatagga gtgtgttatg ggtgctgaac tctctctctt tttccccgat tttccagagc   1380

taggctgtgg agtagagttt gtataggtaa ctaggtaact tattgtggcc cagataaggc   1440

tttaggatgc ctcagtgctt atgtcatagc cttatgagtt agctttcttg ctagccccct   1500

agtcggtcac caaactagta actagtgggg cttaatgaag gtcataagtt tctgagatgg   1560

gagagcaaca agtagagatg aagttaaagg tatttatcat tcaagaaatc attattgagt   1620

caccattgac aggcactatt ctaatcagta gttcacttta atatttaata agattttctg   1680

ggataacagt aagggatatt agataatata ccgtatgtat ttattactag tcttttcctc   1740

taggaaaagg gatactttga taattaaggc cagaggccca ttagttgaga aagtcacaga   1800

tatatttctc caagaaagcc aacaaccacc accacaatga cagaaatgac aacaaggccc   1860

tttaacttgt cttctagttt agagacatcc ttcatttgac atttagtaga attcctcttt   1920

ggccacaaga ataagcagca aataaacaac tatggctgtt gaggttctca ttttggtttg   1980

ttttaatttt ttgaactttg ggtacctgta attagtttaa aaataaagtt cctgataata   2040

aagtgactga aaatggcaaa aaaaaaaaaa aaaa                               2074


<210>  872
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  872

Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp 
1               5                   10                  15      


Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser 
            20                  25                  30          


Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu 
        35                  40                  45              


Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile 
    50                  55                  60                  


His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro 
65                  70                  75                  80  


Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile 
                85                  90                  95      


Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val 
            100                 105                 110         


Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu 
        115                 120                 125             


Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val 
    130                 135                 140                 


Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp 
145                 150                 155                 160 


Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu 
                165                 170                 175     


Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser 
            180                 185                 190         


Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile 
        195                 200                 205             


Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu 
    210                 215                 220                 


Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala 
225                 230                 235                 240 


Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln 
                245                 250                 255     


Ala Lys Lys 
            


<210>  873
<211>  1311
<212>  DNA
<213>  Homosapiens

<400>  873
atgacgaagg agcaacatca gcagaacaga aatacatcag ttgtggtcat gggcagctgt     60

gctctatgtc atagacacca acttcacatc atgtccagct gcctctcgga gctcggctgc    120

ccacagaagc tctggcgcaa tgtctgtgat catcaaagta aaaattcaga caacattggg    180

atagaccagt attcactgga cacggctcag ggctctagaa ataaccagga gcgagaagat    240

atcactcaag ggtccttaaa tacgagaaag gaagagatca ttagggatac tagggaagag    300

ggagcaaaca gcttcatctc atttggacgt cttaaccact gtgggacatc ggagaagcat    360

taccaatgtc cgttcttcac tcaacagatg aagtcaaaag ctgatgattt cctcaaaaag    420

acacaaggtc ttcctgcatt ggtacatgag ggcatggacg agatggagtt cactgaggcc    480

aagtgcaata tgaatgacct ggtgtttgcc taccaacagt accatgatgc cacggctgag    540

gggaagggag cgtttaagga gtgggatgag gaggaggcac agttcccatc tagacttggg    600

cctgccctcg ggggctgcgt gccacaccct tctcccgttt atgggtactt acctgccctg    660

tgccctgtgc caccactatc cgaggaagcc tcctcccctt cccttccccc tcccattgag    720

actgtgaaaa tcctcaagca cgagagggtg caactgctgg ttcggttaac cccatgggac    780

aacacaggga gcgtgacctt ggcggtggca gagcatgcgg cctgcaattg caaccagaaa    840

cgggaagtct tggattgccg gtgcttgggg agtgaggttc ccagctttat gcatcggagt    900

ctgaccagac tgaggatggg aatggttggt aaaaagggaa tcgcagctgg aggtttgtgg    960

gaactggcat attcagacta cacaaaggcc ctgtgtgtgc agacacagcc acagctgtgg   1020

gagccaaggg cctggcaatg gggagaagta ggtatttctc agtgcaggaa agcattcctg   1080

tccgtgctca caatccatct gcagctgcct atggagaagg gctcggtgct gacaggctac   1140

ttagcctcac ctgccttcct gtccggcagt ggtaggattt ccacctctgc ttccatgtat   1200

tggcatggta ggaagacagc cgcagagaac agacagaagc acatcatgct gccagaaggt   1260

tccctggaag aagatacctt gatgcaggac aatggaagaa tccaactcta g            1311


<210>  874
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  874

Met Thr Lys Glu Gln His Gln Gln Asn Arg Asn Thr Ser Val Val Val 
1               5                   10                  15      


Met Gly Ser Cys Ala Leu Cys His Arg His Gln Leu His Ile Met Ser 
            20                  25                  30          


Ser Cys Leu Ser Glu Leu Gly Cys Pro Gln Lys Leu Trp Arg Asn Val 
        35                  40                  45              


Cys Asp His Gln Ser Lys Asn Ser Asp Asn Ile Gly Ile Asp Gln Tyr 
    50                  55                  60                  


Ser Leu Asp Thr Ala Gln Gly Ser Arg Asn Asn Gln Glu Arg Glu Asp 
65                  70                  75                  80  


Ile Thr Gln Gly Ser Leu Asn Thr Arg Lys Glu Glu Ile Ile Arg Asp 
                85                  90                  95      


Thr Arg Glu Glu Gly Ala Asn Ser Phe Ile Ser Phe Gly Arg Leu Asn 
            100                 105                 110         


His Cys Gly Thr Ser Glu Lys His Tyr Gln Cys Pro Phe Phe Thr Gln 
        115                 120                 125             


Gln Met Lys Ser Lys Ala Asp Asp Phe Leu Lys Lys Thr Gln Gly Leu 
    130                 135                 140                 


Pro Ala Leu Val His Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala 
145                 150                 155                 160 


Lys Cys Asn Met Asn Asp Leu Val Phe Ala Tyr Gln Gln Tyr His Asp 
                165                 170                 175     


Ala Thr Ala Glu Gly Lys Gly Ala Phe Lys Glu Trp Asp Glu Glu Glu 
            180                 185                 190         


Ala Gln Phe Pro Ser Arg Leu Gly Pro Ala Leu Gly Gly Cys Val Pro 
        195                 200                 205             


His Pro Ser Pro Val Tyr Gly Tyr Leu Pro Ala Leu Cys Pro Val Pro 
    210                 215                 220                 


Pro Leu Ser Glu Glu Ala Ser Ser Pro Ser Leu Pro Pro Pro Ile Glu 
225                 230                 235                 240 


Thr Val Lys Ile Leu Lys His Glu Arg Val Gln Leu Leu Val Arg Leu 
                245                 250                 255     


Thr Pro Trp Asp Asn Thr Gly Ser Val Thr Leu Ala Val Ala Glu His 
            260                 265                 270         


Ala Ala Cys Asn Cys Asn Gln Lys Arg Glu Val Leu Asp Cys Arg Cys 
        275                 280                 285             


Leu Gly Ser Glu Val Pro Ser Phe Met His Arg Ser Leu Thr Arg Leu 
    290                 295                 300                 


Arg Met Gly Met Val Gly Lys Lys Gly Ile Ala Ala Gly Gly Leu Trp 
305                 310                 315                 320 


Glu Leu Ala Tyr Ser Asp Tyr Thr Lys Ala Leu Cys Val Gln Thr Gln 
                325                 330                 335     


Pro Gln Leu Trp Glu Pro Arg Ala Trp Gln Trp Gly Glu Val Gly Ile 
            340                 345                 350         


Ser Gln Cys Arg Lys Ala Phe Leu Ser Val Leu Thr Ile His Leu Gln 
        355                 360                 365             


Leu Pro Met Glu Lys Gly Ser Val Leu Thr Gly Tyr Leu Ala Ser Pro 
    370                 375                 380                 


Ala Phe Leu Ser Gly Ser Gly Arg Ile Ser Thr Ser Ala Ser Met Tyr 
385                 390                 395                 400 


Trp His Gly Arg Lys Thr Ala Ala Glu Asn Arg Gln Lys His Ile Met 
                405                 410                 415     


Leu Pro Glu Gly Ser Leu Glu Glu Asp Thr Leu Met Gln Asp Asn Gly 
            420                 425                 430         


Arg Ile Gln Leu 
        435     


<210>  875
<211>  4282
<212>  DNA
<213>  Homosapiens

<400>  875
gggaggagta gatttggctg aggacaagcc cagactttcg tcacagggac agaccaacgt     60

gttaacacaa agggagaaca cgggagcatc ctgcaccgtg catttcagcc acagatcaca    120

tggcccctcc gcgggcccag cccacgccct gaccgcccgg cctggccagg tctccgtatc    180

tctctgcccc gccgcccctt cccaactgcg gacatgctgg gtggatccgg atcgcatgga    240

agacgcagcc tggccgcgct ctcccaaatc gcctaccaga ggaatgacga tgatgaagag    300

gaggcagccc gggaacggcg ccgccgagcc cgacaggaac ggctgcggca gaagcaggag    360

gaagaatcct tgggacaggt gaccgaccag gtggaggtga atgcccagaa cagtgtgcct    420

gacgaggagg ccaagacaac caccacaaac actcaagtgg aaggggatga tgaggccgca    480

ttcctggagc gcctggctcg gcgtgaggaa agacgccaaa aacgccttca ggaggctctg    540

gagcggcaga aggagttcga cccaacaata acagatgcaa gtctgtcgct cccaagcaga    600

agaatgcaaa atgacacagc agaaaatgaa actaccgaga aggaagaaaa aagtgaaagt    660

cgccaagaaa gatacgagat agaggaaaca gaaacagtca ccaagtccta ccagaagaat    720

gattggaggg atgctgaaga aaacaagaaa gaagacaagg aaaaggagga ggaggaagag    780

gagaagccaa agcgagggag cattggagaa aatcagggag aagagaaggg aactaaagtg    840

caagctaaaa gagaaaagct ccaagaagac aagcctacct tcaaaaaaga agagatcaaa    900

gatgaaaaga ttaaaaagga caaagaaccc aaagaagaag ttaagagctt catggatcga    960

aagaagggat ttacagaagt taagtcgcag aatggagaat tcatgaccca caaacttaaa   1020

catactgaga atactttcag ccgccctgga gggagggcca gcgtggacac caaggaggct   1080

gagggcgccc cccaggtgga agccggcaaa aggctggagg agcttcgtcg tcgtcgcggg   1140

gagaccgaga gcgaagagtt cgagaagctc aaacagaagc agcaggaggc ggctttggag   1200

ctggaggaac tcaagaaaaa gagggaggag agaaggaagg tcctggagga ggaagagcag   1260

aggaggaagc aggaggaagc cgatcgaaaa ctcagagagg aggaagagaa gaggaggcta   1320

aaggaagaga ttgaaaggcg aagagcagaa gctgctgaga aacgccagaa gatgccagaa   1380

gatggcttgt cagatgacaa gaaaccattc aagtgtttca ctcctaaagg ttcatctctc   1440

aagatagaag agcgagcaga atttttgaat aagtctgtgc agaaaagcag tggtgtcaaa   1500

tcgacccatc aagcagcaat agtctccaag attgacagca gactggagca gtataccagt   1560

gcaattgagg gaacaaaaag cgcaaaacct acaaagccgg cagcctcgga tcttcctgtt   1620

cctgctgaag gtgtacgcaa catcaagagt atgtgggaga aagggaatgt gttttcatcc   1680

cccactgcag caggcacacc aaataaggaa actgctggct tgaaggtagg ggtttctagc   1740

cgcatcaatg aatggctaac taaaacccca gatggaaaca agtcacctgc tcccaaacct   1800

tctgacttga gaccaggaga cgtatccagc aagcggaacc tctgggaaaa gcaatctgtg   1860

gataaggtca cttcccccac taaggtttga gacagttcca gaaagaaccc aagctcaaga   1920

cgcaggacga gctcagttgt agagggctaa ttcgctctgt tttgtattta tgttgattta   1980

ctaaattggg ttcattatct tttatttttc aatatcccag taaacccatg tatattatca   2040

ctatatttaa taatcacagt ctagagatgt tcatggtaaa agtactgcct ttgcacagga   2100

gcctgtttct aaagaaaccc atgctgtgaa atagagactt ttctactgat catcataact   2160

ctgtatctga gcagtgatac caaccacatc tgaagtcaac agaagatcca agtttaaaat   2220

tgcctgcgga atgtgtgcag tatctagaaa aatgaaccgt agtttttgtt tttttaaata   2280

cagaagtcat gttgtttctg cactttataa taaagcatgg aagaaattat cttagtaggc   2340

aattgtaaca ctttttgaaa gtaacccatt tcagatttga aatactgcaa taatggttgt   2400

ctttaaaaaa aaaaaagaaa tgtactgtta aggtattact ttttttcatg ctgatgattc   2460

atatctaaat tacattatta tgttagctga cagtggtact gattttttag gttggttgtt   2520

ttgtggattt ctttagtagt gatagtagcc tgaaccacat tttagataac tcaattatgt   2580

atgtatgtgc atacacatat acaaacacac taatggtaga atgctttttt atgtgctaga   2640

ctattatatt tagtagtatg tcattgtaac tagccaatat cacagctttt gaaaaattaa   2700

aaaatcacac tatattaata tttcatattt gccaacagaa acatggcaga taggtatcaa   2760

tatgttttca atgcctgatg acctataaga agaaagtatt gaaaagaaga gagattagaa   2820

ctgttagaag gagttgaaat tttctaaaag acatagtatt tagtttataa ttaaatgcat   2880

tcttgaagtc cagtgtgaat tttattaatg ctatcatctc gaccaagctc aaagcctact   2940

tattagaaac aatgaagttc acaataggtc ataaggtctc ttccttttct aaaattgaaa   3000

gacaagaaat ttagtgccaa tattgtacag acagaaattc catgtatgag tctcaacaaa   3060

gactaccttt ggctaaatgt ctagaagcag agaagtaaag tgagcaaaat ccagtgttga   3120

ggagtcatga cagtactttg atctttatat actctgaagc atttcttcaa acttttctac   3180

ttttatttgt cattgatacc tgtagtaagt tgacaatgtg gtgaaatttc aaaattatat   3240

gtaacttcta ctagttttac tttctccccc aagtcttttt taactcatga tttttacaca   3300

cacaatccag aacttattat atagcctcta agtctttatt cttcacagta gataatgaaa   3360

gagtcctcca gtgtcttggc aaaatgttct agtatagctg gatacataca gtggagttct   3420

ataaactcat acctcagtgg acttaaccaa aattgtgtta gtctcaattc ctaccacact   3480

gagggagcct cccaaataac tattttctta tctgcagtat tcctccagaa gagctaacca   3540

gggcagggct ggcatgagaa gtgacatctg cgttacaaag tctatcttcc tcataagtct   3600

gtaaagagca attgaatctt ctagctttag caaacctaag ccaaaggaag gaaagccacg   3660

aagaatgcag aagtcaaacc ctcatgacaa agtaggcaca agtctacaat aagctaaatc   3720

agaatttaca aatacaagtg tcccaggtag cattgactcc cgtcattgga gtgaaatgga   3780

tcaaagtttg aattaaggcc tatggtaagg taacattgct ttgttgtact tttgaacaag   3840

agctcctcct gatcactatt acatattttt ctagaaaatc taaagttcag aagagaatgt   3900

atcactgctg acttttattc caatatttgg atggagtaag ttttagggta gaattttgtt   3960

cagtttggat ttaatctttt gaaaagtaaa ttccttgttt actggtttga ctataattct   4020

ctgttatctt tacgaggtaa aactgcaagc tgactagcat gttctgtgaa tctgccattc   4080

ctaaaaattt tataaacact tgatactttt cactgataat ggatcgctcc aataaacata   4140

tattgtgaaa atgcatccac aataaatgga attccttcct gcaaaatgtc tttttctcac   4200

ttatttttat gtacaatatt gatagtgaga ggtatgtcta ttataataaa gattatggca   4260

cagtaaaaaa aaaaaaaaaa aa                                            4282


<210>  876
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  876

Met Leu Gly Gly Ser Gly Ser His Gly Arg Arg Ser Leu Ala Ala Leu 
1               5                   10                  15      


Ser Gln Ile Ala Tyr Gln Arg Asn Asp Asp Asp Glu Glu Glu Ala Ala 
            20                  25                  30          


Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu Arg Leu Arg Gln Lys Gln 
        35                  40                  45              


Glu Glu Glu Ser Leu Gly Gln Val Thr Asp Gln Val Glu Val Asn Ala 
    50                  55                  60                  


Gln Asn Ser Val Pro Asp Glu Glu Ala Lys Thr Thr Thr Thr Asn Thr 
65                  70                  75                  80  


Gln Val Glu Gly Asp Asp Glu Ala Ala Phe Leu Glu Arg Leu Ala Arg 
                85                  90                  95      


Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln Glu Ala Leu Glu Arg Gln 
            100                 105                 110         


Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala Ser Leu Ser Leu Pro Ser 
        115                 120                 125             


Arg Arg Met Gln Asn Asp Thr Ala Glu Asn Glu Thr Thr Glu Lys Glu 
    130                 135                 140                 


Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr Glu Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp Trp Arg Asp Ala Glu Glu 
                165                 170                 175     


Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu Glu Glu Glu Glu Lys Pro 
            180                 185                 190         


Lys Arg Gly Ser Ile Gly Glu Asn Gln Gly Glu Glu Lys Gly Thr Lys 
        195                 200                 205             


Val Gln Ala Lys Arg Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys 
    210                 215                 220                 


Lys Glu Glu Ile Lys Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys 
225                 230                 235                 240 


Glu Glu Val Lys Ser Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val 
                245                 250                 255     


Lys Ser Gln Asn Gly Glu Phe Met Thr His Lys Leu Lys His Thr Glu 
            260                 265                 270         


Asn Thr Phe Ser Arg Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu 
        275                 280                 285             


Ala Glu Gly Ala Pro Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu 
    290                 295                 300                 


Arg Arg Arg Arg Gly Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys 
305                 310                 315                 320 


Gln Lys Gln Gln Glu Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys 
                325                 330                 335     


Arg Glu Glu Arg Arg Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys 
            340                 345                 350         


Gln Glu Glu Ala Asp Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg 
        355                 360                 365             


Leu Lys Glu Glu Ile Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg 
    370                 375                 380                 


Gln Lys Met Pro Glu Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys 
385                 390                 395                 400 


Cys Phe Thr Pro Lys Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu 
                405                 410                 415     


Phe Leu Asn Lys Ser Val Gln Lys Ser Ser Gly Val Lys Ser Thr His 
            420                 425                 430         


Gln Ala Ala Ile Val Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr 
        435                 440                 445             


Ser Ala Ile Glu Gly Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala 
    450                 455                 460                 


Ser Asp Leu Pro Val Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met 
465                 470                 475                 480 


Trp Glu Lys Gly Asn Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro 
                485                 490                 495     


Asn Lys Glu Thr Ala Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn 
            500                 505                 510         


Glu Trp Leu Thr Lys Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys 
        515                 520                 525             


Pro Ser Asp Leu Arg Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp 
    530                 535                 540                 


Glu Lys Gln Ser Val Asp Lys Val Thr Ser Pro Thr Lys Val 
545                 550                 555             


<210>  877
<211>  4204
<212>  DNA
<213>  Homosapiens

<400>  877
gggaggagta gatttggctg aggacaagcc cagactttcg tcacagggac agaccaacgt     60

gttaacacaa agggagaaca cgggagcatc ctgcaccgtg catttcagcc acagatcaca    120

tggcccctcc gcgggcccag cccacgccct gaccgcccgg cctggccagg tctccgtatc    180

tctctgcccc gccgcccctt cccaactgcg gacatgctgg gtggatccgg atcgcatgga    240

agacgcagcc tggccgcgct ctcccaaatc gcctaccaga ggaatgacga tgatgaagag    300

gaggcagccc gggaacggcg ccgccgagcc cgacaggaac ggctgcggca gaagcaggag    360

gaagaatcct tgggacaggt gaccgaccag gtggaggtga atgcccagaa cagtgtgcct    420

gacgaggagg ccaagacaac caccacaaac actcaagtgg aaggggatga tgaggccgca    480

ttcctggagc gcctggctcg gcgtgaggaa agacgccaaa aacgccttca ggaggctctg    540

gagcggcaga aggagttcga cccaacaata acagatgcaa gtctgtcgct cccaagcaga    600

agaatgcaaa atgacacagc agaaaatgaa actaccgaga aggaagaaaa aagtgaaagt    660

cgccaagaaa gatacgagat agaggaaaca gaaacagtca ccaagtccta ccagaagaat    720

gattggaggg atgctgaaga aaacaagaaa gaagacaagg aaaaggagga ggaggaagag    780

gagaagccaa agcgagggag cattggagaa aatcagatca aagatgaaaa gattaaaaag    840

gacaaagaac ccaaagaaga agttaagagc ttcatggatc gaaagaaggg atttacagaa    900

gttaagtcgc agaatggaga attcatgacc cacaaactta aacatactga gaatactttc    960

agccgccctg gagggagggc cagcgtggac accaaggagg ctgagggcgc cccccaggtg   1020

gaagccggca aaaggctgga ggagcttcgt cgtcgtcgcg gggagaccga gagcgaagag   1080

ttcgagaagc tcaaacagaa gcagcaggag gcggctttgg agctggagga actcaagaaa   1140

aagagggagg agagaaggaa ggtcctggag gaggaagagc agaggaggaa gcaggaggaa   1200

gccgatcgaa aactcagaga ggaggaagag aagaggaggc taaaggaaga gattgaaagg   1260

cgaagagcag aagctgctga gaaacgccag aagatgccag aagatggctt gtcagatgac   1320

aagaaaccat tcaagtgttt cactcctaaa ggttcatctc tcaagataga agagcgagca   1380

gaatttttga ataagtctgt gcagaaaagc agtggtgtca aatcgaccca tcaagcagca   1440

atagtctcca agattgacag cagactggag cagtatacca gtgcaattga gggaacaaaa   1500

agcgcaaaac ctacaaagcc ggcagcctcg gatcttcctg ttcctgctga aggtgtacgc   1560

aacatcaaga gtatgtggga gaaagggaat gtgttttcat cccccactgc agcaggcaca   1620

ccaaataagg aaactgctgg cttgaaggta ggggtttcta gccgcatcaa tgaatggcta   1680

actaaaaccc cagatggaaa caagtcacct gctcccaaac cttctgactt gagaccagga   1740

gacgtatcca gcaagcggaa cctctgggaa aagcaatctg tggataaggt cacttccccc   1800

actaaggttt gagacagttc cagaaagaac ccaagctcaa gacgcaggac gagctcagtt   1860

gtagagggct aattcgctct gttttgtatt tatgttgatt tactaaattg ggttcattat   1920

cttttatttt tcaatatccc agtaaaccca tgtatattat cactatattt aataatcaca   1980

gtctagagat gttcatggta aaagtactgc ctttgcacag gagcctgttt ctaaagaaac   2040

ccatgctgtg aaatagagac ttttctactg atcatcataa ctctgtatct gagcagtgat   2100

accaaccaca tctgaagtca acagaagatc caagtttaaa attgcctgcg gaatgtgtgc   2160

agtatctaga aaaatgaacc gtagtttttg tttttttaaa tacagaagtc atgttgtttc   2220

tgcactttat aataaagcat ggaagaaatt atcttagtag gcaattgtaa cactttttga   2280

aagtaaccca tttcagattt gaaatactgc aataatggtt gtctttaaaa aaaaaaaaga   2340

aatgtactgt taaggtatta ctttttttca tgctgatgat tcatatctaa attacattat   2400

tatgttagct gacagtggta ctgatttttt aggttggttg ttttgtggat ttctttagta   2460

gtgatagtag cctgaaccac attttagata actcaattat gtatgtatgt gcatacacat   2520

atacaaacac actaatggta gaatgctttt ttatgtgcta gactattata tttagtagta   2580

tgtcattgta actagccaat atcacagctt ttgaaaaatt aaaaaatcac actatattaa   2640

tatttcatat ttgccaacag aaacatggca gataggtatc aatatgtttt caatgcctga   2700

tgacctataa gaagaaagta ttgaaaagaa gagagattag aactgttaga aggagttgaa   2760

attttctaaa agacatagta tttagtttat aattaaatgc attcttgaag tccagtgtga   2820

attttattaa tgctatcatc tcgaccaagc tcaaagccta cttattagaa acaatgaagt   2880

tcacaatagg tcataaggtc tcttcctttt ctaaaattga aagacaagaa atttagtgcc   2940

aatattgtac agacagaaat tccatgtatg agtctcaaca aagactacct ttggctaaat   3000

gtctagaagc agagaagtaa agtgagcaaa atccagtgtt gaggagtcat gacagtactt   3060

tgatctttat atactctgaa gcatttcttc aaacttttct acttttattt gtcattgata   3120

cctgtagtaa gttgacaatg tggtgaaatt tcaaaattat atgtaacttc tactagtttt   3180

actttctccc ccaagtcttt tttaactcat gatttttaca cacacaatcc agaacttatt   3240

atatagcctc taagtcttta ttcttcacag tagataatga aagagtcctc cagtgtcttg   3300

gcaaaatgtt ctagtatagc tggatacata cagtggagtt ctataaactc atacctcagt   3360

ggacttaacc aaaattgtgt tagtctcaat tcctaccaca ctgagggagc ctcccaaata   3420

actattttct tatctgcagt attcctccag aagagctaac cagggcaggg ctggcatgag   3480

aagtgacatc tgcgttacaa agtctatctt cctcataagt ctgtaaagag caattgaatc   3540

ttctagcttt agcaaaccta agccaaagga aggaaagcca cgaagaatgc agaagtcaaa   3600

ccctcatgac aaagtaggca caagtctaca ataagctaaa tcagaattta caaatacaag   3660

tgtcccaggt agcattgact cccgtcattg gagtgaaatg gatcaaagtt tgaattaagg   3720

cctatggtaa ggtaacattg ctttgttgta cttttgaaca agagctcctc ctgatcacta   3780

ttacatattt ttctagaaaa tctaaagttc agaagagaat gtatcactgc tgacttttat   3840

tccaatattt ggatggagta agttttaggg tagaattttg ttcagtttgg atttaatctt   3900

ttgaaaagta aattccttgt ttactggttt gactataatt ctctgttatc tttacgaggt   3960

aaaactgcaa gctgactagc atgttctgtg aatctgccat tcctaaaaat tttataaaca   4020

cttgatactt ttcactgata atggatcgct ccaataaaca tatattgtga aaatgcatcc   4080

acaataaatg gaattccttc ctgcaaaatg tctttttctc acttattttt atgtacaata   4140

ttgatagtga gaggtatgtc tattataata aagattatgg cacagtaaaa aaaaaaaaaa   4200

aaaa                                                                4204


<210>  878
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  878

Met Leu Gly Gly Ser Gly Ser His Gly Arg Arg Ser Leu Ala Ala Leu 
1               5                   10                  15      


Ser Gln Ile Ala Tyr Gln Arg Asn Asp Asp Asp Glu Glu Glu Ala Ala 
            20                  25                  30          


Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu Arg Leu Arg Gln Lys Gln 
        35                  40                  45              


Glu Glu Glu Ser Leu Gly Gln Val Thr Asp Gln Val Glu Val Asn Ala 
    50                  55                  60                  


Gln Asn Ser Val Pro Asp Glu Glu Ala Lys Thr Thr Thr Thr Asn Thr 
65                  70                  75                  80  


Gln Val Glu Gly Asp Asp Glu Ala Ala Phe Leu Glu Arg Leu Ala Arg 
                85                  90                  95      


Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln Glu Ala Leu Glu Arg Gln 
            100                 105                 110         


Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala Ser Leu Ser Leu Pro Ser 
        115                 120                 125             


Arg Arg Met Gln Asn Asp Thr Ala Glu Asn Glu Thr Thr Glu Lys Glu 
    130                 135                 140                 


Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr Glu Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp Trp Arg Asp Ala Glu Glu 
                165                 170                 175     


Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu Glu Glu Glu Glu Lys Pro 
            180                 185                 190         


Lys Arg Gly Ser Ile Gly Glu Asn Gln Ile Lys Asp Glu Lys Ile Lys 
        195                 200                 205             


Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser Phe Met Asp Arg Lys 
    210                 215                 220                 


Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly Glu Phe Met Thr His 
225                 230                 235                 240 


Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg Pro Gly Gly Arg Ala 
                245                 250                 255     


Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro Gln Val Glu Ala Gly 
            260                 265                 270         


Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly Glu Thr Glu Ser Glu 
        275                 280                 285             


Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu Ala Ala Leu Glu Leu 
    290                 295                 300                 


Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg Lys Val Leu Glu Glu 
305                 310                 315                 320 


Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp Arg Lys Leu Arg Glu 
                325                 330                 335     


Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile Glu Arg Arg Arg Ala 
            340                 345                 350         


Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu Asp Gly Leu Ser Asp 
        355                 360                 365             


Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys Gly Ser Ser Leu Lys 
    370                 375                 380                 


Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser Val Gln Lys Ser Ser 
385                 390                 395                 400 


Gly Val Lys Ser Thr His Gln Ala Ala Ile Val Ser Lys Ile Asp Ser 
                405                 410                 415     


Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly Thr Lys Ser Ala Lys 
            420                 425                 430         


Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val Pro Ala Glu Gly Val 
        435                 440                 445             


Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn Val Phe Ser Ser Pro 
    450                 455                 460                 


Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala Gly Leu Lys Val Gly 
465                 470                 475                 480 


Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys Thr Pro Asp Gly Asn 
                485                 490                 495     


Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg Pro Gly Asp Val Ser 
            500                 505                 510         


Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val Asp Lys Val Thr Ser 
        515                 520                 525             


Pro Thr Lys Val 
    530         


<210>  879
<211>  4546
<212>  DNA
<213>  Homosapiens

<400>  879
gatttcctga gcatgcctag ggaatgacag gcatctccac aggcaggctg catccacctt     60

ggctggggtg tcgtcattgg ctgcctatta gaaaaacgac aggacaatgc ataccaccgc    120

ctcccgactg taaacatagg ggatatgtgt tcacttagca tggacttctg ggaggggcca    180

aggaagggcg gtctggagtt ttattgaata gagcagtgtg tattcggctg cctgcctgcc    240

cgcctgcttg ctctctggct gtgctcctgc ttaaagaaat cagtccttcc tttccgactt    300

agtcctcggg aagaagtttc agactacaag gtatcattgg aacatttcaa gatcatcaaa    360

tcaaattcca cagggattgg tgaccaacca gaaggctcag acatctgatt gctgacctgt    420

ccagacatca tctggtctcc ctgaacctga aatcacacca tggatgattt tgagcgtcgc    480

agagaactta gaaggcaaaa gagggaggag atgcgactcg aagcagaaag aatcgcctac    540

cagaggaatg acgatgatga agaggaggca gcccgggaac ggcgccgccg agcccgacag    600

gaacggctgc ggcagaagca ggaggaagaa tccttgggac aggtgaccga ccaggtggag    660

gtgaatgccc agaacagtgt gcctgacgag gaggccaaga caaccaccac aaacactcaa    720

gtggaagggg atgatgaggc cgcattcctg gagcgcctgg ctcggcgtga ggaaagacgc    780

caaaaacgcc ttcaggaggc tctggagcgg cagaaggagt tcgacccaac aataacagat    840

gcaagtctgt cgctcccaag cagaagaatg caaaatgaca cagcagaaaa tgaaactacc    900

gagaaggaag aaaaaagtga aagtcgccaa gaaagatacg agatagagga aacagaaaca    960

gtcaccaagt cctaccagaa gaatgattgg agggatgctg aagaaaacaa gaaagaagac   1020

aaggaaaagg aggaggagga agaggagaag ccaaagcgag ggagcattgg agaaaatcag   1080

ggagaagaga agggaactaa agtgcaagct aaaagagaaa agctccaaga agacaagcct   1140

accttcaaaa aagaagagat caaagatgaa aagattaaaa aggacaaaga acccaaagaa   1200

gaagttaaga gcttcatgga tcgaaagaag ggatttacag aagttaagtc gcagaatgga   1260

gaattcatga cccacaaact taaacatact gagaatactt tcagccgccc tggagggagg   1320

gccagcgtgg acaccaagga ggctgagggc gccccccagg tggaagccgg caaaaggctg   1380

gaggagcttc gtcgtcgtcg cggggagacc gagagcgaag agttcgagaa gctcaaacag   1440

aagcagcagg aggcggcttt ggagctggag gaactcaaga aaaagaggga ggagagaagg   1500

aaggtcctgg aggaggaaga gcagaggagg aagcaggagg aagccgatcg aaaactcaga   1560

gaggaggaag agaagaggag gctaaaggaa gagattgaaa ggcgaagagc agaagctgct   1620

gagaaacgcc agaagatgcc agaagatggc ttgtcagatg acaagaaacc attcaagtgt   1680

ttcactccta aaggttcatc tctcaagata gaagagcgag cagaattttt gaataagtct   1740

gtgcagaaaa gcagtggtgt caaatcgacc catcaagcag caatagtctc caagattgac   1800

agcagactgg agcagtatac cagtgcaatt gagggaacaa aaagcgcaaa acctacaaag   1860

ccggcagcct cggatcttcc tgttcctgct gaaggtgtac gcaacatcaa gagtatgtgg   1920

gagaaaggga atgtgttttc atcccccact gcagcaggca caccaaataa ggaaactgct   1980

ggcttgaagg taggggtttc tagccgcatc aatgaatggc taactaaaac cccagatgga   2040

aacaagtcac ctgctcccaa accttctgac ttgagaccag gagacgtatc cagcaagcgg   2100

aacctctggg aaaagcaatc tgtggataag gtcacttccc ccactaaggt ttgagacagt   2160

tccagaaaga acccaagctc aagacgcagg acgagctcag ttgtagaggg ctaattcgct   2220

ctgttttgta tttatgttga tttactaaat tgggttcatt atcttttatt tttcaatatc   2280

ccagtaaacc catgtatatt atcactatat ttaataatca cagtctagag atgttcatgg   2340

taaaagtact gcctttgcac aggagcctgt ttctaaagaa acccatgctg tgaaatagag   2400

acttttctac tgatcatcat aactctgtat ctgagcagtg ataccaacca catctgaagt   2460

caacagaaga tccaagttta aaattgcctg cggaatgtgt gcagtatcta gaaaaatgaa   2520

ccgtagtttt tgttttttta aatacagaag tcatgttgtt tctgcacttt ataataaagc   2580

atggaagaaa ttatcttagt aggcaattgt aacacttttt gaaagtaacc catttcagat   2640

ttgaaatact gcaataatgg ttgtctttaa aaaaaaaaaa gaaatgtact gttaaggtat   2700

tacttttttt catgctgatg attcatatct aaattacatt attatgttag ctgacagtgg   2760

tactgatttt ttaggttggt tgttttgtgg atttctttag tagtgatagt agcctgaacc   2820

acattttaga taactcaatt atgtatgtat gtgcatacac atatacaaac acactaatgg   2880

tagaatgctt ttttatgtgc tagactatta tatttagtag tatgtcattg taactagcca   2940

atatcacagc ttttgaaaaa ttaaaaaatc acactatatt aatatttcat atttgccaac   3000

agaaacatgg cagataggta tcaatatgtt ttcaatgcct gatgacctat aagaagaaag   3060

tattgaaaag aagagagatt agaactgtta gaaggagttg aaattttcta aaagacatag   3120

tatttagttt ataattaaat gcattcttga agtccagtgt gaattttatt aatgctatca   3180

tctcgaccaa gctcaaagcc tacttattag aaacaatgaa gttcacaata ggtcataagg   3240

tctcttcctt ttctaaaatt gaaagacaag aaatttagtg ccaatattgt acagacagaa   3300

attccatgta tgagtctcaa caaagactac ctttggctaa atgtctagaa gcagagaagt   3360

aaagtgagca aaatccagtg ttgaggagtc atgacagtac tttgatcttt atatactctg   3420

aagcatttct tcaaactttt ctacttttat ttgtcattga tacctgtagt aagttgacaa   3480

tgtggtgaaa tttcaaaatt atatgtaact tctactagtt ttactttctc ccccaagtct   3540

tttttaactc atgattttta cacacacaat ccagaactta ttatatagcc tctaagtctt   3600

tattcttcac agtagataat gaaagagtcc tccagtgtct tggcaaaatg ttctagtata   3660

gctggataca tacagtggag ttctataaac tcatacctca gtggacttaa ccaaaattgt   3720

gttagtctca attcctacca cactgaggga gcctcccaaa taactatttt cttatctgca   3780

gtattcctcc agaagagcta accagggcag ggctggcatg agaagtgaca tctgcgttac   3840

aaagtctatc ttcctcataa gtctgtaaag agcaattgaa tcttctagct ttagcaaacc   3900

taagccaaag gaaggaaagc cacgaagaat gcagaagtca aaccctcatg acaaagtagg   3960

cacaagtcta caataagcta aatcagaatt tacaaataca agtgtcccag gtagcattga   4020

ctcccgtcat tggagtgaaa tggatcaaag tttgaattaa ggcctatggt aaggtaacat   4080

tgctttgttg tacttttgaa caagagctcc tcctgatcac tattacatat ttttctagaa   4140

aatctaaagt tcagaagaga atgtatcact gctgactttt attccaatat ttggatggag   4200

taagttttag ggtagaattt tgttcagttt ggatttaatc ttttgaaaag taaattcctt   4260

gtttactggt ttgactataa ttctctgtta tctttacgag gtaaaactgc aagctgacta   4320

gcatgttctg tgaatctgcc attcctaaaa attttataaa cacttgatac ttttcactga   4380

taatggatcg ctccaataaa catatattgt gaaaatgcat ccacaataaa tggaattcct   4440

tcctgcaaaa tgtctttttc tcacttattt ttatgtacaa tattgatagt gagaggtatg   4500

tctattataa taaagattat ggcacagtaa aaaaaaaaaa aaaaaa                  4546


<210>  880
<211>  564
<212>  PRT
<213>  Homosapiens

<400>  880

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Gly 
        195                 200                 205             


Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg Glu Lys Leu Gln Glu 
    210                 215                 220                 


Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys Asp Glu Lys Ile Lys 
225                 230                 235                 240 


Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser Phe Met Asp Arg Lys 
                245                 250                 255     


Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly Glu Phe Met Thr His 
            260                 265                 270         


Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg Pro Gly Gly Arg Ala 
        275                 280                 285             


Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro Gln Val Glu Ala Gly 
    290                 295                 300                 


Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly Glu Thr Glu Ser Glu 
305                 310                 315                 320 


Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu Ala Ala Leu Glu Leu 
                325                 330                 335     


Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg Lys Val Leu Glu Glu 
            340                 345                 350         


Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp Arg Lys Leu Arg Glu 
        355                 360                 365             


Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile Glu Arg Arg Arg Ala 
    370                 375                 380                 


Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu Asp Gly Leu Ser Asp 
385                 390                 395                 400 


Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys Gly Ser Ser Leu Lys 
                405                 410                 415     


Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser Val Gln Lys Ser Ser 
            420                 425                 430         


Gly Val Lys Ser Thr His Gln Ala Ala Ile Val Ser Lys Ile Asp Ser 
        435                 440                 445             


Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly Thr Lys Ser Ala Lys 
    450                 455                 460                 


Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val Pro Ala Glu Gly Val 
465                 470                 475                 480 


Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn Val Phe Ser Ser Pro 
                485                 490                 495     


Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala Gly Leu Lys Val Gly 
            500                 505                 510         


Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys Thr Pro Asp Gly Asn 
        515                 520                 525             


Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg Pro Gly Asp Val Ser 
    530                 535                 540                 


Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val Asp Lys Val Thr Ser 
545                 550                 555                 560 


Pro Thr Lys Val 
                


<210>  881
<211>  4468
<212>  DNA
<213>  Homosapiens

<400>  881
gatttcctga gcatgcctag ggaatgacag gcatctccac aggcaggctg catccacctt     60

ggctggggtg tcgtcattgg ctgcctatta gaaaaacgac aggacaatgc ataccaccgc    120

ctcccgactg taaacatagg ggatatgtgt tcacttagca tggacttctg ggaggggcca    180

aggaagggcg gtctggagtt ttattgaata gagcagtgtg tattcggctg cctgcctgcc    240

cgcctgcttg ctctctggct gtgctcctgc ttaaagaaat cagtccttcc tttccgactt    300

agtcctcggg aagaagtttc agactacaag gtatcattgg aacatttcaa gatcatcaaa    360

tcaaattcca cagggattgg tgaccaacca gaaggctcag acatctgatt gctgacctgt    420

ccagacatca tctggtctcc ctgaacctga aatcacacca tggatgattt tgagcgtcgc    480

agagaactta gaaggcaaaa gagggaggag atgcgactcg aagcagaaag aatcgcctac    540

cagaggaatg acgatgatga agaggaggca gcccgggaac ggcgccgccg agcccgacag    600

gaacggctgc ggcagaagca ggaggaagaa tccttgggac aggtgaccga ccaggtggag    660

gtgaatgccc agaacagtgt gcctgacgag gaggccaaga caaccaccac aaacactcaa    720

gtggaagggg atgatgaggc cgcattcctg gagcgcctgg ctcggcgtga ggaaagacgc    780

caaaaacgcc ttcaggaggc tctggagcgg cagaaggagt tcgacccaac aataacagat    840

gcaagtctgt cgctcccaag cagaagaatg caaaatgaca cagcagaaaa tgaaactacc    900

gagaaggaag aaaaaagtga aagtcgccaa gaaagatacg agatagagga aacagaaaca    960

gtcaccaagt cctaccagaa gaatgattgg agggatgctg aagaaaacaa gaaagaagac   1020

aaggaaaagg aggaggagga agaggagaag ccaaagcgag ggagcattgg agaaaatcag   1080

atcaaagatg aaaagattaa aaaggacaaa gaacccaaag aagaagttaa gagcttcatg   1140

gatcgaaaga agggatttac agaagttaag tcgcagaatg gagaattcat gacccacaaa   1200

cttaaacata ctgagaatac tttcagccgc cctggaggga gggccagcgt ggacaccaag   1260

gaggctgagg gcgcccccca ggtggaagcc ggcaaaaggc tggaggagct tcgtcgtcgt   1320

cgcggggaga ccgagagcga agagttcgag aagctcaaac agaagcagca ggaggcggct   1380

ttggagctgg aggaactcaa gaaaaagagg gaggagagaa ggaaggtcct ggaggaggaa   1440

gagcagagga ggaagcagga ggaagccgat cgaaaactca gagaggagga agagaagagg   1500

aggctaaagg aagagattga aaggcgaaga gcagaagctg ctgagaaacg ccagaagatg   1560

ccagaagatg gcttgtcaga tgacaagaaa ccattcaagt gtttcactcc taaaggttca   1620

tctctcaaga tagaagagcg agcagaattt ttgaataagt ctgtgcagaa aagcagtggt   1680

gtcaaatcga cccatcaagc agcaatagtc tccaagattg acagcagact ggagcagtat   1740

accagtgcaa ttgagggaac aaaaagcgca aaacctacaa agccggcagc ctcggatctt   1800

cctgttcctg ctgaaggtgt acgcaacatc aagagtatgt gggagaaagg gaatgtgttt   1860

tcatccccca ctgcagcagg cacaccaaat aaggaaactg ctggcttgaa ggtaggggtt   1920

tctagccgca tcaatgaatg gctaactaaa accccagatg gaaacaagtc acctgctccc   1980

aaaccttctg acttgagacc aggagacgta tccagcaagc ggaacctctg ggaaaagcaa   2040

tctgtggata aggtcacttc ccccactaag gtttgagaca gttccagaaa gaacccaagc   2100

tcaagacgca ggacgagctc agttgtagag ggctaattcg ctctgttttg tatttatgtt   2160

gatttactaa attgggttca ttatctttta tttttcaata tcccagtaaa cccatgtata   2220

ttatcactat atttaataat cacagtctag agatgttcat ggtaaaagta ctgcctttgc   2280

acaggagcct gtttctaaag aaacccatgc tgtgaaatag agacttttct actgatcatc   2340

ataactctgt atctgagcag tgataccaac cacatctgaa gtcaacagaa gatccaagtt   2400

taaaattgcc tgcggaatgt gtgcagtatc tagaaaaatg aaccgtagtt tttgtttttt   2460

taaatacaga agtcatgttg tttctgcact ttataataaa gcatggaaga aattatctta   2520

gtaggcaatt gtaacacttt ttgaaagtaa cccatttcag atttgaaata ctgcaataat   2580

ggttgtcttt aaaaaaaaaa aagaaatgta ctgttaaggt attacttttt ttcatgctga   2640

tgattcatat ctaaattaca ttattatgtt agctgacagt ggtactgatt ttttaggttg   2700

gttgttttgt ggatttcttt agtagtgata gtagcctgaa ccacatttta gataactcaa   2760

ttatgtatgt atgtgcatac acatatacaa acacactaat ggtagaatgc ttttttatgt   2820

gctagactat tatatttagt agtatgtcat tgtaactagc caatatcaca gcttttgaaa   2880

aattaaaaaa tcacactata ttaatatttc atatttgcca acagaaacat ggcagatagg   2940

tatcaatatg ttttcaatgc ctgatgacct ataagaagaa agtattgaaa agaagagaga   3000

ttagaactgt tagaaggagt tgaaattttc taaaagacat agtatttagt ttataattaa   3060

atgcattctt gaagtccagt gtgaatttta ttaatgctat catctcgacc aagctcaaag   3120

cctacttatt agaaacaatg aagttcacaa taggtcataa ggtctcttcc ttttctaaaa   3180

ttgaaagaca agaaatttag tgccaatatt gtacagacag aaattccatg tatgagtctc   3240

aacaaagact acctttggct aaatgtctag aagcagagaa gtaaagtgag caaaatccag   3300

tgttgaggag tcatgacagt actttgatct ttatatactc tgaagcattt cttcaaactt   3360

ttctactttt atttgtcatt gatacctgta gtaagttgac aatgtggtga aatttcaaaa   3420

ttatatgtaa cttctactag ttttactttc tcccccaagt cttttttaac tcatgatttt   3480

tacacacaca atccagaact tattatatag cctctaagtc tttattcttc acagtagata   3540

atgaaagagt cctccagtgt cttggcaaaa tgttctagta tagctggata catacagtgg   3600

agttctataa actcatacct cagtggactt aaccaaaatt gtgttagtct caattcctac   3660

cacactgagg gagcctccca aataactatt ttcttatctg cagtattcct ccagaagagc   3720

taaccagggc agggctggca tgagaagtga catctgcgtt acaaagtcta tcttcctcat   3780

aagtctgtaa agagcaattg aatcttctag ctttagcaaa cctaagccaa aggaaggaaa   3840

gccacgaaga atgcagaagt caaaccctca tgacaaagta ggcacaagtc tacaataagc   3900

taaatcagaa tttacaaata caagtgtccc aggtagcatt gactcccgtc attggagtga   3960

aatggatcaa agtttgaatt aaggcctatg gtaaggtaac attgctttgt tgtacttttg   4020

aacaagagct cctcctgatc actattacat atttttctag aaaatctaaa gttcagaaga   4080

gaatgtatca ctgctgactt ttattccaat atttggatgg agtaagtttt agggtagaat   4140

tttgttcagt ttggatttaa tcttttgaaa agtaaattcc ttgtttactg gtttgactat   4200

aattctctgt tatctttacg aggtaaaact gcaagctgac tagcatgttc tgtgaatctg   4260

ccattcctaa aaattttata aacacttgat acttttcact gataatggat cgctccaata   4320

aacatatatt gtgaaaatgc atccacaata aatggaattc cttcctgcaa aatgtctttt   4380

tctcacttat ttttatgtac aatattgata gtgagaggta tgtctattat aataaagatt   4440

atggcacagt aaaaaaaaaa aaaaaaaa                                      4468


<210>  882
<211>  538
<212>  PRT
<213>  Homosapiens

<400>  882

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Ile 
        195                 200                 205             


Lys Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys 
    210                 215                 220                 


Ser Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn 
225                 230                 235                 240 


Gly Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser 
                245                 250                 255     


Arg Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala 
            260                 265                 270         


Pro Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg 
        275                 280                 285             


Gly Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln 
    290                 295                 300                 


Glu Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg 
305                 310                 315                 320 


Arg Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala 
                325                 330                 335     


Asp Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu 
            340                 345                 350         


Ile Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro 
        355                 360                 365             


Glu Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro 
    370                 375                 380                 


Lys Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys 
385                 390                 395                 400 


Ser Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile 
                405                 410                 415     


Val Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu 
            420                 425                 430         


Gly Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro 
        435                 440                 445             


Val Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly 
    450                 455                 460                 


Asn Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr 
465                 470                 475                 480 


Ala Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr 
                485                 490                 495     


Lys Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu 
            500                 505                 510         


Arg Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser 
        515                 520                 525             


Val Asp Lys Val Thr Ser Pro Thr Lys Val 
    530                 535             


<210>  883
<211>  5233
<212>  DNA
<213>  Homosapiens

<400>  883
gatttcctga gcatgcctag ggaatgacag gcatctccac aggcaggctg catccacctt     60

ggctggggtg tcgtcattgg ctgcctatta gaaaaacgac aggacaatgc ataccaccgc    120

ctcccgactg taaacatagg ggatatgtgt tcacttagca tggacttctg ggaggggcca    180

aggaagggcg gtctggagtt ttattgaata gagcagtgtg tattcggctg cctgcctgcc    240

cgcctgcttg ctctctggct gtgctcctgc ttaaagaaat cagtccttcc tttccgactt    300

agtcctcggg aagaagtttc agactacaag gtatcattgg aacatttcaa gatcatcaaa    360

tcaaattcca cagggattgg tgaccaacca gaaggctcag acatctgatt gctgacctgt    420

ccagacatca tctggtctcc ctgaacctga aatcacacca tggatgattt tgagcgtcgc    480

agagaactta gaaggcaaaa gagggaggag atgcgactcg aagcagaaag aatcgcctac    540

cagaggaatg acgatgatga agaggaggca gcccgggaac ggcgccgccg agcccgacag    600

gaacggctgc ggcagaagca ggaggaagaa tccttgggac aggtgaccga ccaggtggag    660

gtgaatgccc agaacagtgt gcctgacgag gaggccaaga caaccaccac aaacactcaa    720

gtggaagggg atgatgaggc cgcattcctg gagcgcctgg ctcggcgtga ggaaagacgc    780

caaaaacgcc ttcaggaggc tctggagcgg cagaaggagt tcgacccaac aataacagat    840

gcaagtctgt cgctcccaag cagaagaatg caaaatgaca cagcagaaaa tgaaactacc    900

gagaaggaag aaaaaagtga aagtcgccaa gaaagatacg agatagagga aacagaaaca    960

gtcaccaagt cctaccagaa gaatgattgg agggatgctg aagaaaacaa gaaagaagac   1020

aaggaaaagg aggaggagga agaggagaag ccaaagcgag ggagcattgg agaaaatcag   1080

gtagaggtga tggtggaaga gaaaacaact gaaagccagg aggaaacagt ggtaatgtca   1140

ttaaaaaatg ggcagatcag ttcagaagag cctaaacaag aggaggagag ggaacaaggt   1200

tcagatgaga tttcccatca tgaaaagatg gaagaggaag acaaggaaag agctgaggca   1260

gagagggcaa ggttggaagc agaagaaaga gaaagaatta aagccgagca agacaaaaag   1320

atagcagatg aacgagcaag aattgaagca gaagaaaaag cagctgccca agaaagagaa   1380

aggagagagg cagaagagag ggaaaggatg agggaggaag agaaaagggc agcagaggag   1440

aggcagagga taaaggagga agagaaaagg gcagcagagg agaggcagag gataaaggag   1500

gaagagaaaa gggcagcaga ggagaggcag aggataaaag aggaagagaa aagggcagca   1560

gaggagaggc aaagggccag ggcagaggag gaagagaagg ctaaggtaga agagcagaaa   1620

cgtaacaagc agctagaaga gaaaaaacat gccatgcaag agacaaagat aaaaggggaa   1680

aaggtagaac agaaaataga agggaaatgg gtaaatgaaa agaaagcaca agaagataaa   1740

cttcagacag ctgtcctaaa gaaacaggga gaagagaagg gaactaaagt gcaagctaaa   1800

agagaaaagc tccaagaaga caagcctacc ttcaaaaaag aagagatcaa agatgaaaag   1860

attaaaaagg acaaagaacc caaagaagaa gttaagagct tcatggatcg aaagaaggga   1920

tttacagaag ttaagtcgca gaatggagaa ttcatgaccc acaaacttaa acatactgag   1980

aatactttca gccgccctgg agggagggcc agcgtggaca ccaaggaggc tgagggcgcc   2040

ccccaggtgg aagccggcaa aaggctggag gagcttcgtc gtcgtcgcgg ggagaccgag   2100

agcgaagagt tcgagaagct caaacagaag cagcaggagg cggctttgga gctggaggaa   2160

ctcaagaaaa agagggagga gagaaggaag gtcctggagg aggaagagca gaggaggaag   2220

caggaggaag ccgatcgaaa actcagagag gaggaagaga agaggaggct aaaggaagag   2280

attgaaaggc gaagagcaga agctgctgag aaacgccaga agatgccaga agatggcttg   2340

tcagatgaca agaaaccatt caagtgtttc actcctaaag gttcatctct caagatagaa   2400

gagcgagcag aatttttgaa taagtctgtg cagaaaagca gtggtgtcaa atcgacccat   2460

caagcagcaa tagtctccaa gattgacagc agactggagc agtataccag tgcaattgag   2520

ggaacaaaaa gcgcaaaacc tacaaagccg gcagcctcgg atcttcctgt tcctgctgaa   2580

ggtgtacgca acatcaagag tatgtgggag aaagggaatg tgttttcatc ccccactgca   2640

gcaggcacac caaataagga aactgctggc ttgaaggtag gggtttctag ccgcatcaat   2700

gaatggctaa ctaaaacccc agatggaaac aagtcacctg ctcccaaacc ttctgacttg   2760

agaccaggag acgtatccag caagcggaac ctctgggaaa agcaatctgt ggataaggtc   2820

acttccccca ctaaggtttg agacagttcc agaaagaacc caagctcaag acgcaggacg   2880

agctcagttg tagagggcta attcgctctg ttttgtattt atgttgattt actaaattgg   2940

gttcattatc ttttattttt caatatccca gtaaacccat gtatattatc actatattta   3000

ataatcacag tctagagatg ttcatggtaa aagtactgcc tttgcacagg agcctgtttc   3060

taaagaaacc catgctgtga aatagagact tttctactga tcatcataac tctgtatctg   3120

agcagtgata ccaaccacat ctgaagtcaa cagaagatcc aagtttaaaa ttgcctgcgg   3180

aatgtgtgca gtatctagaa aaatgaaccg tagtttttgt ttttttaaat acagaagtca   3240

tgttgtttct gcactttata ataaagcatg gaagaaatta tcttagtagg caattgtaac   3300

actttttgaa agtaacccat ttcagatttg aaatactgca ataatggttg tctttaaaaa   3360

aaaaaaagaa atgtactgtt aaggtattac tttttttcat gctgatgatt catatctaaa   3420

ttacattatt atgttagctg acagtggtac tgatttttta ggttggttgt tttgtggatt   3480

tctttagtag tgatagtagc ctgaaccaca ttttagataa ctcaattatg tatgtatgtg   3540

catacacata tacaaacaca ctaatggtag aatgcttttt tatgtgctag actattatat   3600

ttagtagtat gtcattgtaa ctagccaata tcacagcttt tgaaaaatta aaaaatcaca   3660

ctatattaat atttcatatt tgccaacaga aacatggcag ataggtatca atatgttttc   3720

aatgcctgat gacctataag aagaaagtat tgaaaagaag agagattaga actgttagaa   3780

ggagttgaaa ttttctaaaa gacatagtat ttagtttata attaaatgca ttcttgaagt   3840

ccagtgtgaa ttttattaat gctatcatct cgaccaagct caaagcctac ttattagaaa   3900

caatgaagtt cacaataggt cataaggtct cttccttttc taaaattgaa agacaagaaa   3960

tttagtgcca atattgtaca gacagaaatt ccatgtatga gtctcaacaa agactacctt   4020

tggctaaatg tctagaagca gagaagtaaa gtgagcaaaa tccagtgttg aggagtcatg   4080

acagtacttt gatctttata tactctgaag catttcttca aacttttcta cttttatttg   4140

tcattgatac ctgtagtaag ttgacaatgt ggtgaaattt caaaattata tgtaacttct   4200

actagtttta ctttctcccc caagtctttt ttaactcatg atttttacac acacaatcca   4260

gaacttatta tatagcctct aagtctttat tcttcacagt agataatgaa agagtcctcc   4320

agtgtcttgg caaaatgttc tagtatagct ggatacatac agtggagttc tataaactca   4380

tacctcagtg gacttaacca aaattgtgtt agtctcaatt cctaccacac tgagggagcc   4440

tcccaaataa ctattttctt atctgcagta ttcctccaga agagctaacc agggcagggc   4500

tggcatgaga agtgacatct gcgttacaaa gtctatcttc ctcataagtc tgtaaagagc   4560

aattgaatct tctagcttta gcaaacctaa gccaaaggaa ggaaagccac gaagaatgca   4620

gaagtcaaac cctcatgaca aagtaggcac aagtctacaa taagctaaat cagaatttac   4680

aaatacaagt gtcccaggta gcattgactc ccgtcattgg agtgaaatgg atcaaagttt   4740

gaattaaggc ctatggtaag gtaacattgc tttgttgtac ttttgaacaa gagctcctcc   4800

tgatcactat tacatatttt tctagaaaat ctaaagttca gaagagaatg tatcactgct   4860

gacttttatt ccaatatttg gatggagtaa gttttagggt agaattttgt tcagtttgga   4920

tttaatcttt tgaaaagtaa attccttgtt tactggtttg actataattc tctgttatct   4980

ttacgaggta aaactgcaag ctgactagca tgttctgtga atctgccatt cctaaaaatt   5040

ttataaacac ttgatacttt tcactgataa tggatcgctc caataaacat atattgtgaa   5100

aatgcatcca caataaatgg aattccttcc tgcaaaatgt ctttttctca cttattttta   5160

tgtacaatat tgatagtgag aggtatgtct attataataa agattatggc acagtaaaaa   5220

aaaaaaaaaa aaa                                                      5233


<210>  884
<211>  793
<212>  PRT
<213>  Homosapiens

<400>  884

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
        195                 200                 205             


Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
    210                 215                 220                 


Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
225                 230                 235                 240 


Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                245                 250                 255     


Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
            260                 265                 270         


Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
        275                 280                 285             


Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
    290                 295                 300                 


Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
305                 310                 315                 320 


Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                325                 330                 335     


Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
            340                 345                 350         


Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
        355                 360                 365             


Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
    370                 375                 380                 


Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys His Ala Met Gln 
385                 390                 395                 400 


Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                405                 410                 415     


Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
            420                 425                 430         


Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
        435                 440                 445             


Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
    450                 455                 460                 


Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
465                 470                 475                 480 


Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                485                 490                 495     


Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
            500                 505                 510         


Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
        515                 520                 525             


Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
    530                 535                 540                 


Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
545                 550                 555                 560 


Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                565                 570                 575     


Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
            580                 585                 590         


Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
        595                 600                 605             


Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
    610                 615                 620                 


Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
625                 630                 635                 640 


Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                645                 650                 655     


Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
            660                 665                 670         


Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
        675                 680                 685             


Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
    690                 695                 700                 


Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
705                 710                 715                 720 


Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                725                 730                 735     


Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
            740                 745                 750         


Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
        755                 760                 765             


Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
    770                 775                 780                 


Asp Lys Val Thr Ser Pro Thr Lys Val 
785                 790             


<210>  885
<211>  2735
<212>  DNA
<213>  Homosapiens

<400>  885
agcagaggga tcatgacggg gaaaaagtcc tcccgggaga aacggcgcaa acgtagcagt     60

caggaggcgg ccgcagcgct cgcggccccg gacatcgtac ccgcgttggc cagcggcagc    120

agtggaagca ctagcggctg cgggagcgcc gggggctgcg ggagcgtcag ctgctgtggg    180

aacgccaatt ttagtggaag tgtcaccggc ggtgggagcg gcggcagctg ttggggcggg    240

agcagcgtgg agcgcagcga gcgccggaag cggaggagta ccgactcttc cagcgtctcg    300

ggctccttgc agcaggaaac taaatatatt ttgccaactt tggaaaaaga attattcttg    360

gcagagcaca gtgaccttga agaaggtgga ctggacctga ctgtgtcatt gaaaccagtt    420

agtttctata tatcagacaa aaaagaaatg cttcagcagt gcttctgtat tataggagag    480

aaaaagttac agaagatgct tcctgatgtg ttaaagaact gttcaataga agaaattaaa    540

aaactatgcc aggaacagtt agagctcctg tctgaaaaaa aaattttgaa gattcttgag    600

ggtgacaatg gaatggactc tgatatggaa gaggaagcag atgatggttc taagatggga    660

tctgatttag tcagtcagca agacatctgt atagattctg cttcatccgt gagagagaat    720

aagcaacctg aaggtttgga attaaaacaa ggaaaagggg aagatagtga tgtactcagt    780

ataaatgcag atgcttatga cagcgacata gaaggcccat gcaacgaaga agcagctgct    840

cccgaggcac cagaaaatac agtccaaagt gaagctggtc agataaatga cctggagaaa    900

gacattgaga aaagtgtgaa tgagattcta ggactggcag agtctagccc aaacgaaccc    960

aaagcagcca ccctggctgt tcctccacca gaagatgttc aaccttctgc acagcaactg   1020

gagctgctag aacttgagat gagggcaaga gcgattaaag ccctaatgaa agctggtgat   1080

ataaaaaagc cagcctaggt atttaacttg attttgaatt ttaggtatgt ttgaacaaag   1140

ccacatcatt taattttgta tctaaaattt atttggggtc ttatatgtta tttctcatgt   1200

aacccttatt aggactcatt ttagccctaa attacctgtg gctgtttctt tttatttttt   1260

tgactacttt tatattataa atgtgtgtta ctgtcttatg aattcatggc aatatagttg   1320

gatagcctgg atactttgtt agatgagtat ttagctgtgt ctgcaaatct taaaagccat   1380

tagcaaagag tcgtggtatt tttttcttta tttttaaatg tttgggcacc aaacctaaaa   1440

gcaaaagatt gacgaagcat gtttctctta aggctacttg tattttacaa tacaatatta   1500

aattatttaa tttgagaaat ttagttttgc ttatatgcac tttttaaata tatactattt   1560

tgaagattcc ttatgtaaat gcaaatttcc tagttaaaac cgaataacag agatctgaaa   1620

tgactgagaa aaactttttt attaaaggaa ggaattaatt taaggcaatt tttaactatg   1680

tagaactaat tgcccatgtt taattatagc agacacgcca ttctaacagg tatttgatac   1740

cattggatgc attattctag gttttttctt taataaaaat ggaacaagtt ttcatttaca   1800

ttccaagctg tcaggaaatg aagaatattt tattatctag gattttatct gatgtagttg   1860

cttaaagatc tgatgtgcta taattccatg aatcagaaat aataaaatgc tatcattctg   1920

gatctgaaga cttttgatac tttttcaaaa gcaaaattaa tttcaggaac ctttgataag   1980

ttgttgttat aattaatcta attttgtata gtttttgtaa ataaattacc atccttccac   2040

aattagggat gcttttatcc ccccatcact aattgcagtt gtttgatacc aaaataaatt   2100

tacgtagaga tccttaactt aaaataaatt aattttttca aaaaacataa atctggaact   2160

gttgtttcta tatttgataa caaatacagt atattttatt tataagccat ggtctactga   2220

tactgtatga ggactttcct tatatataaa agttgcaggg attgtgtttt attagctgct   2280

ttaattatgt taattttaga gagtttttaa atggaaatag aggacattta tgaaacgctg   2340

gaattgcagt tacaaattct ttttgttgtt gttgttcctg aacatgcctt ggaataattc   2400

taccattttt tccccctcca taaatctttc taataaagca tagaaaaagc ctatatgatt   2460

ttaaatgctt ctcttaagct ggtaaacaga tttgagttat gagttcattg ttattgcttc   2520

aagatgaaaa gacagtgata taatttttct atttcaactt aaaagtaata gttaatatgc   2580

taaagtagta cagaataaac tttattgctg cttactaact acaaaatact gtagatggca   2640

tctgtatgat taaacatata aagtaaaaca ggtctgaggg ctttgtagat gattaaagtc   2700

tccaccttca tgaaaaaaaa aaaaaaaaaa aaaaa                              2735


<210>  886
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  886

Met Thr Gly Lys Lys Ser Ser Arg Glu Lys Arg Arg Lys Arg Ser Ser 
1               5                   10                  15      


Gln Glu Ala Ala Ala Ala Leu Ala Ala Pro Asp Ile Val Pro Ala Leu 
            20                  25                  30          


Ala Ser Gly Ser Ser Gly Ser Thr Ser Gly Cys Gly Ser Ala Gly Gly 
        35                  40                  45              


Cys Gly Ser Val Ser Cys Cys Gly Asn Ala Asn Phe Ser Gly Ser Val 
    50                  55                  60                  


Thr Gly Gly Gly Ser Gly Gly Ser Cys Trp Gly Gly Ser Ser Val Glu 
65                  70                  75                  80  


Arg Ser Glu Arg Arg Lys Arg Arg Ser Thr Asp Ser Ser Ser Val Ser 
                85                  90                  95      


Gly Ser Leu Gln Gln Glu Thr Lys Tyr Ile Leu Pro Thr Leu Glu Lys 
            100                 105                 110         


Glu Leu Phe Leu Ala Glu His Ser Asp Leu Glu Glu Gly Gly Leu Asp 
        115                 120                 125             


Leu Thr Val Ser Leu Lys Pro Val Ser Phe Tyr Ile Ser Asp Lys Lys 
    130                 135                 140                 


Glu Met Leu Gln Gln Cys Phe Cys Ile Ile Gly Glu Lys Lys Leu Gln 
145                 150                 155                 160 


Lys Met Leu Pro Asp Val Leu Lys Asn Cys Ser Ile Glu Glu Ile Lys 
                165                 170                 175     


Lys Leu Cys Gln Glu Gln Leu Glu Leu Leu Ser Glu Lys Lys Ile Leu 
            180                 185                 190         


Lys Ile Leu Glu Gly Asp Asn Gly Met Asp Ser Asp Met Glu Glu Glu 
        195                 200                 205             


Ala Asp Asp Gly Ser Lys Met Gly Ser Asp Leu Val Ser Gln Gln Asp 
    210                 215                 220                 


Ile Cys Ile Asp Ser Ala Ser Ser Val Arg Glu Asn Lys Gln Pro Glu 
225                 230                 235                 240 


Gly Leu Glu Leu Lys Gln Gly Lys Gly Glu Asp Ser Asp Val Leu Ser 
                245                 250                 255     


Ile Asn Ala Asp Ala Tyr Asp Ser Asp Ile Glu Gly Pro Cys Asn Glu 
            260                 265                 270         


Glu Ala Ala Ala Pro Glu Ala Pro Glu Asn Thr Val Gln Ser Glu Ala 
        275                 280                 285             


Gly Gln Ile Asn Asp Leu Glu Lys Asp Ile Glu Lys Ser Val Asn Glu 
    290                 295                 300                 


Ile Leu Gly Leu Ala Glu Ser Ser Pro Asn Glu Pro Lys Ala Ala Thr 
305                 310                 315                 320 


Leu Ala Val Pro Pro Pro Glu Asp Val Gln Pro Ser Ala Gln Gln Leu 
                325                 330                 335     


Glu Leu Leu Glu Leu Glu Met Arg Ala Arg Ala Ile Lys Ala Leu Met 
            340                 345                 350         


Lys Ala Gly Asp Ile Lys Lys Pro Ala 
        355                 360     


<210>  887
<211>  2719
<212>  DNA
<213>  Homosapiens

<400>  887
ccacgcgtcc gggctcttct cccgccgcgg cccggcgctc tccgagtcgc ccctgcggac     60

tggtctcgca cagtgcctgg gcaccgggcg ccagacagac actggccatg acgagcggcg    120

caaccaggta ccggctgagc tgctcgctcc ggggccacga gctggacgta cggggcctgg    180

tgtgctgcgc ctatccgccg ggagcctttg tgtccgtgtc ccgagaccgc accacccgcc    240

tctgggcccc agacagtcca aacaggagct ttacagaaat gcactgtatg agtggccatt    300

ccaattttgt atcttgtgta tgcatcatac cctcaagtga catctaccct catggcctaa    360

ttgccaccgg tggaaatgac cacaatatat gcattttctc actggacagt ccaatgccac    420

tttatattct aaaaggccac aaaaatactg tttgtagtct atcatctgga aaatttggga    480

cattacttag tggttcatgg gacaccactg ctaaagtctg gctgaatgac aagtgcatga    540

tgaccttgca gggtcataca gctgcagtgt gggcggtaaa gatcttacct gaacagggct    600

taatgttgac tggatcagca gacaagactg ttaaactgtg gaaggctgga agatgtgaga    660

ggactttttc agggcatgaa gactgtgtaa gaggtttggc aattttgagt gaaacagaat    720

ttctttcctg tgcaaatgat gctagtatta gaaggtggca aatcactggc gagtgtcttg    780

aagtatatta tggacataca aattatattt atagcatatc cgtttttcca aattgtagag    840

actttgtgac aacagcagag gacagatctc tgagaatctg gaaacatggg gaatgtgctc    900

aaactatccg acttccagct cagtctatat ggtgctgctg tgtgctcgac aatggtgaca    960

ttgtggttgg tgcgagtgat ggcattatta gagtgtttac agaatcagaa gatcgaacag   1020

caagtgctga agaaatcaag gcttttgaaa aagaactgtc tcacgcaacc attgattcta   1080

aaactggcga tttaggggac atcaatgctg agcagcttcc tgggagggaa catcttaatg   1140

aacctggtac tagagaagga cagactcgtc taatcagaga tggggagaaa gtcgaagcct   1200

atcagtggag tgttagtgaa gggaggtgga taaaaattgg tgatgttgtt ggctcatctg   1260

gtgctaatca gcaaacatct ggaaaagttt tatatgaagg gaaagaattt gattatgttt   1320

tctcaattga tgtcaatgaa ggtggaccat catataaatt gccatataat accagtgatg   1380

acccttggtt aactgcatac aacttcttac agaagaatga tttgaatcct atgtttctgg   1440

atcaagtagc taaatttatt attgataaca caaaaggtca aatgttggga cttgggaatc   1500

ccagcttttc agatccattt acaggtggtg gtcggtatgt tccgggctct tcgggatctt   1560

ctaacacact acccacagca gatcctttta caggtgctgg tcgttatgta ccaggttctg   1620

caagtatggg aactaccatg gccggagttg atccatttac agggaatagt gcctaccgat   1680

cagctgcatc taaaacaatg aatatttatt tccctaaaaa agaggctgtc acatttgacc   1740

aagcaaaccc tacacaaata ttaggtaaac tgaaggaact taatggaact gcacctgaag   1800

agaagaagtt aactgaggat gacttgatac ttcttgagaa gatactgtct ctaatatgta   1860

atagttcttc agaaaaaccc acagtccagc aacttcagat tttgtggaaa gctattaact   1920

gtcctgaaga tattgtcttt cctgcacttg acattcttcg gttgtcaatt aaacacccca   1980

gtgtgaatga gaacttctgc aatgaaaagg aaggggctca gttcagcagt catcttatca   2040

atcttctgaa ccctaaagga aagccagcaa accagctgct tgctctcagg actttttgca   2100

attgttttgt tggccaggca ggacaaaaac tcatgatgtc ccagagggaa tcactgatgt   2160

cccatgcaat agaactgaaa tcagggagca ataagaacat tcacattgct ctggctacat   2220

tggccctgaa ctattctgtt tgttttcata aagaccataa cattgaaggg aaagcccaat   2280

gtttgtcact aattagcaca atcttggaag tagtacaaga cctagaagcc acttttagac   2340

ttcttgtggc tcttggaaca cttatcagtg atgattcaaa tgctgtacaa ttagccaagt   2400

ctttaggtgt tgattctcaa ataaaaaagt attcctcagt atcagaacca gctaaagtaa   2460

gtgaatgctg tagatttatc ctaaatttgc tgtagcagtg gggaagaggg acggatattt   2520

ttaattgatt agtgtttttt tcctcacatt tgacatgact gataacagat aattaaaaaa   2580

agagaatacg gtggattaag taaaatttta catcttgtaa agtggtgggg aggggaaaca   2640

gaaataaaat ttttgcactg ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2700

aaaaaaaaaa aaaaaaaaa                                                2719


<210>  888
<211>  795
<212>  PRT
<213>  Homosapiens

<400>  888

Met Thr Ser Gly Ala Thr Arg Tyr Arg Leu Ser Cys Ser Leu Arg Gly 
1               5                   10                  15      


His Glu Leu Asp Val Arg Gly Leu Val Cys Cys Ala Tyr Pro Pro Gly 
            20                  25                  30          


Ala Phe Val Ser Val Ser Arg Asp Arg Thr Thr Arg Leu Trp Ala Pro 
        35                  40                  45              


Asp Ser Pro Asn Arg Ser Phe Thr Glu Met His Cys Met Ser Gly His 
    50                  55                  60                  


Ser Asn Phe Val Ser Cys Val Cys Ile Ile Pro Ser Ser Asp Ile Tyr 
65                  70                  75                  80  


Pro His Gly Leu Ile Ala Thr Gly Gly Asn Asp His Asn Ile Cys Ile 
                85                  90                  95      


Phe Ser Leu Asp Ser Pro Met Pro Leu Tyr Ile Leu Lys Gly His Lys 
            100                 105                 110         


Asn Thr Val Cys Ser Leu Ser Ser Gly Lys Phe Gly Thr Leu Leu Ser 
        115                 120                 125             


Gly Ser Trp Asp Thr Thr Ala Lys Val Trp Leu Asn Asp Lys Cys Met 
    130                 135                 140                 


Met Thr Leu Gln Gly His Thr Ala Ala Val Trp Ala Val Lys Ile Leu 
145                 150                 155                 160 


Pro Glu Gln Gly Leu Met Leu Thr Gly Ser Ala Asp Lys Thr Val Lys 
                165                 170                 175     


Leu Trp Lys Ala Gly Arg Cys Glu Arg Thr Phe Ser Gly His Glu Asp 
            180                 185                 190         


Cys Val Arg Gly Leu Ala Ile Leu Ser Glu Thr Glu Phe Leu Ser Cys 
        195                 200                 205             


Ala Asn Asp Ala Ser Ile Arg Arg Trp Gln Ile Thr Gly Glu Cys Leu 
    210                 215                 220                 


Glu Val Tyr Tyr Gly His Thr Asn Tyr Ile Tyr Ser Ile Ser Val Phe 
225                 230                 235                 240 


Pro Asn Cys Arg Asp Phe Val Thr Thr Ala Glu Asp Arg Ser Leu Arg 
                245                 250                 255     


Ile Trp Lys His Gly Glu Cys Ala Gln Thr Ile Arg Leu Pro Ala Gln 
            260                 265                 270         


Ser Ile Trp Cys Cys Cys Val Leu Asp Asn Gly Asp Ile Val Val Gly 
        275                 280                 285             


Ala Ser Asp Gly Ile Ile Arg Val Phe Thr Glu Ser Glu Asp Arg Thr 
    290                 295                 300                 


Ala Ser Ala Glu Glu Ile Lys Ala Phe Glu Lys Glu Leu Ser His Ala 
305                 310                 315                 320 


Thr Ile Asp Ser Lys Thr Gly Asp Leu Gly Asp Ile Asn Ala Glu Gln 
                325                 330                 335     


Leu Pro Gly Arg Glu His Leu Asn Glu Pro Gly Thr Arg Glu Gly Gln 
            340                 345                 350         


Thr Arg Leu Ile Arg Asp Gly Glu Lys Val Glu Ala Tyr Gln Trp Ser 
        355                 360                 365             


Val Ser Glu Gly Arg Trp Ile Lys Ile Gly Asp Val Val Gly Ser Ser 
    370                 375                 380                 


Gly Ala Asn Gln Gln Thr Ser Gly Lys Val Leu Tyr Glu Gly Lys Glu 
385                 390                 395                 400 


Phe Asp Tyr Val Phe Ser Ile Asp Val Asn Glu Gly Gly Pro Ser Tyr 
                405                 410                 415     


Lys Leu Pro Tyr Asn Thr Ser Asp Asp Pro Trp Leu Thr Ala Tyr Asn 
            420                 425                 430         


Phe Leu Gln Lys Asn Asp Leu Asn Pro Met Phe Leu Asp Gln Val Ala 
        435                 440                 445             


Lys Phe Ile Ile Asp Asn Thr Lys Gly Gln Met Leu Gly Leu Gly Asn 
    450                 455                 460                 


Pro Ser Phe Ser Asp Pro Phe Thr Gly Gly Gly Arg Tyr Val Pro Gly 
465                 470                 475                 480 


Ser Ser Gly Ser Ser Asn Thr Leu Pro Thr Ala Asp Pro Phe Thr Gly 
                485                 490                 495     


Ala Gly Arg Tyr Val Pro Gly Ser Ala Ser Met Gly Thr Thr Met Ala 
            500                 505                 510         


Gly Val Asp Pro Phe Thr Gly Asn Ser Ala Tyr Arg Ser Ala Ala Ser 
        515                 520                 525             


Lys Thr Met Asn Ile Tyr Phe Pro Lys Lys Glu Ala Val Thr Phe Asp 
    530                 535                 540                 


Gln Ala Asn Pro Thr Gln Ile Leu Gly Lys Leu Lys Glu Leu Asn Gly 
545                 550                 555                 560 


Thr Ala Pro Glu Glu Lys Lys Leu Thr Glu Asp Asp Leu Ile Leu Leu 
                565                 570                 575     


Glu Lys Ile Leu Ser Leu Ile Cys Asn Ser Ser Ser Glu Lys Pro Thr 
            580                 585                 590         


Val Gln Gln Leu Gln Ile Leu Trp Lys Ala Ile Asn Cys Pro Glu Asp 
        595                 600                 605             


Ile Val Phe Pro Ala Leu Asp Ile Leu Arg Leu Ser Ile Lys His Pro 
    610                 615                 620                 


Ser Val Asn Glu Asn Phe Cys Asn Glu Lys Glu Gly Ala Gln Phe Ser 
625                 630                 635                 640 


Ser His Leu Ile Asn Leu Leu Asn Pro Lys Gly Lys Pro Ala Asn Gln 
                645                 650                 655     


Leu Leu Ala Leu Arg Thr Phe Cys Asn Cys Phe Val Gly Gln Ala Gly 
            660                 665                 670         


Gln Lys Leu Met Met Ser Gln Arg Glu Ser Leu Met Ser His Ala Ile 
        675                 680                 685             


Glu Leu Lys Ser Gly Ser Asn Lys Asn Ile His Ile Ala Leu Ala Thr 
    690                 695                 700                 


Leu Ala Leu Asn Tyr Ser Val Cys Phe His Lys Asp His Asn Ile Glu 
705                 710                 715                 720 


Gly Lys Ala Gln Cys Leu Ser Leu Ile Ser Thr Ile Leu Glu Val Val 
                725                 730                 735     


Gln Asp Leu Glu Ala Thr Phe Arg Leu Leu Val Ala Leu Gly Thr Leu 
            740                 745                 750         


Ile Ser Asp Asp Ser Asn Ala Val Gln Leu Ala Lys Ser Leu Gly Val 
        755                 760                 765             


Asp Ser Gln Ile Lys Lys Tyr Ser Ser Val Ser Glu Pro Ala Lys Val 
    770                 775                 780                 


Ser Glu Cys Cys Arg Phe Ile Leu Asn Leu Leu 
785                 790                 795 


<210>  889
<211>  3240
<212>  DNA
<213>  Homosapiens

<400>  889
agacagtcca aacaggagct ttacagaaat gcactgtatg agtggccatt ccaattttgt     60

atcttgtgta tgcatcatac cctcaagtga catctaccct catggcctaa ttgccaccgg    120

tggaaatgac cacaatatat gcattttctc actggacagt ccaatgccac tttatattct    180

aaaaggccac aaaaatactg tttgtagtct atcatctgga aaatttggga cattacttag    240

tggttcatgg gacaccactg ctaaagtctg gctgaatgac aagtgcatga tgaccttgca    300

gggtcataca gctgcagtgt gggcggtaaa gatcttacct gaacagggct taatgttgac    360

tggatcagca gacaagactg ttaaactgtg gaaggctgga agatgtgaga ggactttttc    420

agggcatgaa gactgtgtaa gaggtttggc aattttgagt gaaacagaat ttctttcctg    480

tgcaaatgat gctagtatta gaaggtggca aatcactggc gagtgtcttg aagtatatta    540

tggacataca aattatattt atagcatatc cgtttttcca aattgtagag actttgtgac    600

aacagcagag gacagatctc tgagaatctg gaaacatggg gaatgtgctc aaactatccg    660

acttccagct cagtctatat ggtgctgctg tgtgctcgac aatggtgaca ttgtggttgg    720

tgcgagtgat ggcattatta gagtgtttac agaatcagaa gatcgaacag caagtgctga    780

agaaatcaag gcttttgaaa aagaactgtc tcacgcaacc attgattcta aaactggcga    840

tttaggggac atcaatgctg agcagcttcc tgggagggaa catcttaatg aacctggtac    900

tagagaagga cagactcgtc taatcagaga tggggagaaa gtcgaagcct atcagtggag    960

tgttagtgaa gggaggtgga taaaaattgg tgatgttgtt ggctcatctg gtgctaatca   1020

gcaaacatct ggaaaagttt tatatgaagg gaaagaattt gattatgttt tctcaattga   1080

tgtcaatgaa ggtggaccat catataaatt gccatataat accagtgatg acccttggtt   1140

aactgcatac aacttcttac agaagaatga tttgaatcct atgtttctgg atcaagtagc   1200

taaatttatt attgataaca caaaaggtca aatgttggga cttgggaatc ccagcttttc   1260

agatccattt acaggtggtg gtcggtatgt tccgggctct tcgggatctt ctaacacact   1320

acccacagca gatcctttta caggtgctgg tcgttatgta ccaggttctg caagtatggg   1380

aactaccatg gccggagttg atccatttac agggaatagt gcctaccgat cagctgcatc   1440

taaaacaatg aatatttatt tccctaaaaa agaggctgtc acatttgacc aagcaaaccc   1500

tacacaaata ttaggtaaac tgaaggaact taatggaact gcacctgaag agaagaagtt   1560

aactgaggat gacttgatac ttcttgagaa gatactgtct ctaatatgta atagttcttc   1620

agaaaaaccc acagtccagc aacttcagat tttgtggaaa gctattaact gtcctgaaga   1680

tattgtcttt cctgcacttg acattcttcg gttgtcaatt aaacacccca gtgtgaatga   1740

gaacttctgc aatgaaaagg aaggggctca gttcagcagt catcttatca atcttctgaa   1800

ccctaaagga aagccagcaa accagctgct tgctctcagg actttttgca attgttttgt   1860

tggccaggca ggacaaaaac tcatgatgtc ccagagggaa tcactgatgt cccatgcaat   1920

agaactgaaa tcagggagca ataagaacat tcacattgct ctggctacat tggccctgaa   1980

ctattctgtt tgttttcata aagaccataa cattgaaggg aaagcccaat gtttgtcact   2040

aattagcaca atcttggaag tagtacaaga cctagaagcc acttttagac ttcttgtggc   2100

tcttggaaca cttatcagtg atgattcaaa tgctgtacaa ttagccaagt ctttaggtgt   2160

tgattctcaa ataaaaaagt attcctcagt atcagaacca gctaaagtaa gtgaatgctg   2220

tagatttatc ctaaatttgc tgtagcagtg gggaagaggg acggatattt ttaattgatt   2280

agtgtttttt tcctcacatt tgacatgact gataacagat aattaaaaaa agagaatacg   2340

gtggattaag taaaatttta catcttgtaa agtggtgggg aggggaaaca gaaataaaat   2400

ttttgcactg ctgaactgtg agattttcct gtgtaatttg ggtagatttt caagagtgtg   2460

aacacaaatt taaaataagc tataatcagc aacaacacaa tgacaatgac atcttcccct   2520

taccttagcc actaagaaga caagggctgt tactcatata acttgctttt cttacttaat   2580

gtacaccaaa ctgttgttgt caattatctt ttatttaact tctccacctt cattgctaga   2640

tccttcgaac agcactgata catttcaagg tcttgtttta ggataactac tttaaaattt   2700

tttaaattat attaaattta taaaataatt tataaattca tatattaaaa caatataaga   2760

taatttcttg atttgtcatt tataaatccc taaagtatat ttgtttaatg gcctattttt   2820

ggatgaagaa aaagccagtt ggtaagctgt gttagtcatg tatcagttca gacagacgga   2880

ggtctcaatt taactccagg cttagatccc agtttccttt tgcccttcac tatttgaggt   2940

aacttcattt ttcattctag ttttgatatt tggctgttta tttttgtcat tttccattat   3000

ttcaaaggga atttggaaca tgttgaattt tatcaggtgg ttacataagc aagagtacat   3060

caaactgtat tatttgaaag tctagaacct gtcatgtgaa attactattt ttgagccctc   3120

tatgtggtcc aggcagaata gtagacacac tgatatttaa tccttaaaac ccctttaaat   3180

gagggccagt attatctctg ctttcagaag tagacataat aggatgaatc atataacaga   3240


<210>  890
<211>  738
<212>  PRT
<213>  Homosapiens

<400>  890

Met His Cys Met Ser Gly His Ser Asn Phe Val Ser Cys Val Cys Ile 
1               5                   10                  15      


Ile Pro Ser Ser Asp Ile Tyr Pro His Gly Leu Ile Ala Thr Gly Gly 
            20                  25                  30          


Asn Asp His Asn Ile Cys Ile Phe Ser Leu Asp Ser Pro Met Pro Leu 
        35                  40                  45              


Tyr Ile Leu Lys Gly His Lys Asn Thr Val Cys Ser Leu Ser Ser Gly 
    50                  55                  60                  


Lys Phe Gly Thr Leu Leu Ser Gly Ser Trp Asp Thr Thr Ala Lys Val 
65                  70                  75                  80  


Trp Leu Asn Asp Lys Cys Met Met Thr Leu Gln Gly His Thr Ala Ala 
                85                  90                  95      


Val Trp Ala Val Lys Ile Leu Pro Glu Gln Gly Leu Met Leu Thr Gly 
            100                 105                 110         


Ser Ala Asp Lys Thr Val Lys Leu Trp Lys Ala Gly Arg Cys Glu Arg 
        115                 120                 125             


Thr Phe Ser Gly His Glu Asp Cys Val Arg Gly Leu Ala Ile Leu Ser 
    130                 135                 140                 


Glu Thr Glu Phe Leu Ser Cys Ala Asn Asp Ala Ser Ile Arg Arg Trp 
145                 150                 155                 160 


Gln Ile Thr Gly Glu Cys Leu Glu Val Tyr Tyr Gly His Thr Asn Tyr 
                165                 170                 175     


Ile Tyr Ser Ile Ser Val Phe Pro Asn Cys Arg Asp Phe Val Thr Thr 
            180                 185                 190         


Ala Glu Asp Arg Ser Leu Arg Ile Trp Lys His Gly Glu Cys Ala Gln 
        195                 200                 205             


Thr Ile Arg Leu Pro Ala Gln Ser Ile Trp Cys Cys Cys Val Leu Asp 
    210                 215                 220                 


Asn Gly Asp Ile Val Val Gly Ala Ser Asp Gly Ile Ile Arg Val Phe 
225                 230                 235                 240 


Thr Glu Ser Glu Asp Arg Thr Ala Ser Ala Glu Glu Ile Lys Ala Phe 
                245                 250                 255     


Glu Lys Glu Leu Ser His Ala Thr Ile Asp Ser Lys Thr Gly Asp Leu 
            260                 265                 270         


Gly Asp Ile Asn Ala Glu Gln Leu Pro Gly Arg Glu His Leu Asn Glu 
        275                 280                 285             


Pro Gly Thr Arg Glu Gly Gln Thr Arg Leu Ile Arg Asp Gly Glu Lys 
    290                 295                 300                 


Val Glu Ala Tyr Gln Trp Ser Val Ser Glu Gly Arg Trp Ile Lys Ile 
305                 310                 315                 320 


Gly Asp Val Val Gly Ser Ser Gly Ala Asn Gln Gln Thr Ser Gly Lys 
                325                 330                 335     


Val Leu Tyr Glu Gly Lys Glu Phe Asp Tyr Val Phe Ser Ile Asp Val 
            340                 345                 350         


Asn Glu Gly Gly Pro Ser Tyr Lys Leu Pro Tyr Asn Thr Ser Asp Asp 
        355                 360                 365             


Pro Trp Leu Thr Ala Tyr Asn Phe Leu Gln Lys Asn Asp Leu Asn Pro 
    370                 375                 380                 


Met Phe Leu Asp Gln Val Ala Lys Phe Ile Ile Asp Asn Thr Lys Gly 
385                 390                 395                 400 


Gln Met Leu Gly Leu Gly Asn Pro Ser Phe Ser Asp Pro Phe Thr Gly 
                405                 410                 415     


Gly Gly Arg Tyr Val Pro Gly Ser Ser Gly Ser Ser Asn Thr Leu Pro 
            420                 425                 430         


Thr Ala Asp Pro Phe Thr Gly Ala Gly Arg Tyr Val Pro Gly Ser Ala 
        435                 440                 445             


Ser Met Gly Thr Thr Met Ala Gly Val Asp Pro Phe Thr Gly Asn Ser 
    450                 455                 460                 


Ala Tyr Arg Ser Ala Ala Ser Lys Thr Met Asn Ile Tyr Phe Pro Lys 
465                 470                 475                 480 


Lys Glu Ala Val Thr Phe Asp Gln Ala Asn Pro Thr Gln Ile Leu Gly 
                485                 490                 495     


Lys Leu Lys Glu Leu Asn Gly Thr Ala Pro Glu Glu Lys Lys Leu Thr 
            500                 505                 510         


Glu Asp Asp Leu Ile Leu Leu Glu Lys Ile Leu Ser Leu Ile Cys Asn 
        515                 520                 525             


Ser Ser Ser Glu Lys Pro Thr Val Gln Gln Leu Gln Ile Leu Trp Lys 
    530                 535                 540                 


Ala Ile Asn Cys Pro Glu Asp Ile Val Phe Pro Ala Leu Asp Ile Leu 
545                 550                 555                 560 


Arg Leu Ser Ile Lys His Pro Ser Val Asn Glu Asn Phe Cys Asn Glu 
                565                 570                 575     


Lys Glu Gly Ala Gln Phe Ser Ser His Leu Ile Asn Leu Leu Asn Pro 
            580                 585                 590         


Lys Gly Lys Pro Ala Asn Gln Leu Leu Ala Leu Arg Thr Phe Cys Asn 
        595                 600                 605             


Cys Phe Val Gly Gln Ala Gly Gln Lys Leu Met Met Ser Gln Arg Glu 
    610                 615                 620                 


Ser Leu Met Ser His Ala Ile Glu Leu Lys Ser Gly Ser Asn Lys Asn 
625                 630                 635                 640 


Ile His Ile Ala Leu Ala Thr Leu Ala Leu Asn Tyr Ser Val Cys Phe 
                645                 650                 655     


His Lys Asp His Asn Ile Glu Gly Lys Ala Gln Cys Leu Ser Leu Ile 
            660                 665                 670         


Ser Thr Ile Leu Glu Val Val Gln Asp Leu Glu Ala Thr Phe Arg Leu 
        675                 680                 685             


Leu Val Ala Leu Gly Thr Leu Ile Ser Asp Asp Ser Asn Ala Val Gln 
    690                 695                 700                 


Leu Ala Lys Ser Leu Gly Val Asp Ser Gln Ile Lys Lys Tyr Ser Ser 
705                 710                 715                 720 


Val Ser Glu Pro Ala Lys Val Ser Glu Cys Cys Arg Phe Ile Leu Asn 
                725                 730                 735     


Leu Leu 
        


<210>  891
<211>  1995
<212>  DNA
<213>  Homosapiens

<400>  891
agttagtggg taggcctgag agccgaggaa aactgagcgt gggcctcaga aagaagtcaa     60

ggcacccgcg agccgggcaa ctgccctcct tccgcgccgg cggagcgatt aaagtgaaga    120

aacaatggcc agcaatcaca aatcttcagc agctcgccct gtttcaagag gtggagttgg    180

gttaacagga aggcctcctt ctgggatacg acccctatca ggaaatattc gagtggcaac    240

tgcaatgcca cctgggacag caagaccagg ttctcgtggt tgtcccatag ggactggtgg    300

agttctgtct tctcaaatca aagttgccca tcgccctgta acacaacaag gtttgactgg    360

aatgaaaact gggacgaaag gtccccagag gcaaatttta gacaaatctt actatcttgg    420

gcttcttaga agtaaaataa gtgaacttac aactgaagtt aataaacttc agaagggaat    480

agaaatgtac aatcaagaga attcagtata tttgtcatat gaaaagaggg ctgagacttt    540

agctgttgag ataaaagagc ttcaaggaca actagcagac tacaacatgt tggtagatta    600

acttaatacc aacactgaaa tggaagaagt aatgaatggt tacaatatgc ttaaagctca    660

aaatgatcga gaaacacaaa gtttggatgt catatttact gaaagacaag cgaaagaaaa    720

acaaatcaga agtgtcgaag aagaaattga acaggaaaaa caagcaacag atgacattat    780

caaaaatatg tctcttgaaa accaagtcaa gtacctagag atgaaaacca caaatgagaa    840

actgttacag gaattagata cacttcaaca acaattggat tcacagaaca tgaaaaaaga    900

gagcctggaa gcagaaatag ctcactccca ggtgaaacag gaggcggtat tgctgcatga    960

aaaactttat gagttggagt cccatcgaga tcaaatgatt gcagaagaca aaagcatagg   1020

atctccaatg gaagagagag agaaattact taagcagatt aaagatgata atcaggaaat   1080

agccagcatg gaaagacagt taacagatac aaaagaaaag ataaatcagt ttattgaaga   1140

aattagacaa cttgacatgg atttagagga acaccaaggt gaaatgaacc agaaatacaa   1200

ggagctaaag aaaagggagg aacatatgga cacttttatt gagacttttg aggaaacaaa   1260

gaatcaggaa ctgaaacgaa aggcacagat agaagccaac attgttgcac tcttggagca   1320

ctgcagtcga aatataaatc gtatagaaca gatatcctct atcaccaatc aagagctaaa   1380

gatgatgcag gatgacctca attttaaatc tactgaagtg cagaaatcac aaagtacagc   1440

tcagaatttg acttcagaca ttcaacgtct gcagttggat ctgcagaaaa tggagcttct   1500

agaaagtaag atgactgaag aacagcattc tctaaaaagc aaaattaagc aaatgacaac   1560

tgatctggag atatataatg atttgccagc tttaaaatca tcaggtgaag aaaagataaa   1620

gaaattacat caggagagaa tgatattatc aacccacaga aatgccttta agaaaataat   1680

ggagaagcaa aacatagagt atgaggcact aaaaacacaa ttgcaagaaa atgagacaca   1740

ttctcagctt acaaatttgg agagaaagtg gcaacacctt gagcaaaata attttgcgat   1800

gaaagaattc atagcaacca agagtcaaga gagtgattac cagccaatta agaaaaatgt   1860

gaccaagcag attgcagagt acaataaaac catcgtggat gctttacata gcaccagcgg   1920

aaactgagtt taagtccact gaaagtctct aaggaagtat cctcttgctg ctaaacttgg   1980

tacaagttga ctacc                                                    1995


<210>  892
<211>  435
<212>  PRT
<213>  Homosapiens

<400>  892

Met Glu Glu Val Met Asn Gly Tyr Asn Met Leu Lys Ala Gln Asn Asp 
1               5                   10                  15      


Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr Glu Arg Gln Ala Lys 
            20                  25                  30          


Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile Glu Gln Glu Lys Gln 
        35                  40                  45              


Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Leu Glu Asn Gln Val Lys 
    50                  55                  60                  


Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu Leu Gln Glu Leu Asp 
65                  70                  75                  80  


Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met Lys Lys Glu Ser Leu 
                85                  90                  95      


Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln Glu Ala Val Leu Leu 
            100                 105                 110         


His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg Asp Gln Met Ile Ala 
        115                 120                 125             


Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu Arg Glu Lys Leu Leu 
    130                 135                 140                 


Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala Ser Met Glu Arg Gln 
145                 150                 155                 160 


Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe Ile Glu Glu Ile Arg 
                165                 170                 175     


Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly Glu Met Asn Gln Lys 
            180                 185                 190         


Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met Asp Thr Phe Ile Glu 
        195                 200                 205             


Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys Arg Lys Ala Gln Ile 
    210                 215                 220                 


Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys Ser Arg Asn Ile Asn 
225                 230                 235                 240 


Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln Glu Leu Lys Met Met 
                245                 250                 255     


Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val Gln Lys Ser Gln Ser 
            260                 265                 270         


Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg Leu Gln Leu Asp Leu 
        275                 280                 285             


Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr Glu Glu Gln His Ser 
    290                 295                 300                 


Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp Leu Glu Ile Tyr Asn 
305                 310                 315                 320 


Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Glu Lys Ile Lys Lys Leu 
                325                 330                 335     


His Gln Glu Arg Met Ile Leu Ser Thr His Arg Asn Ala Phe Lys Lys 
            340                 345                 350         


Ile Met Glu Lys Gln Asn Ile Glu Tyr Glu Ala Leu Lys Thr Gln Leu 
        355                 360                 365             


Gln Glu Asn Glu Thr His Ser Gln Leu Thr Asn Leu Glu Arg Lys Trp 
    370                 375                 380                 


Gln His Leu Glu Gln Asn Asn Phe Ala Met Lys Glu Phe Ile Ala Thr 
385                 390                 395                 400 


Lys Ser Gln Glu Ser Asp Tyr Gln Pro Ile Lys Lys Asn Val Thr Lys 
                405                 410                 415     


Gln Ile Ala Glu Tyr Asn Lys Thr Ile Val Asp Ala Leu His Ser Thr 
            420                 425                 430         


Ser Gly Asn 
        435 


<210>  893
<211>  3160
<212>  DNA
<213>  Homosapiens

<400>  893
atacgatgta ctttttttaa tgccgttgaa acagagttaa tttcctttag cacacaagtc     60

ttagagacaa aagaaaaaaa ggtctgcaac atgaaagtca caggcatcac aatcctcttt    120

tggcccctct ccatgatatt attatcagac aaaatccagt cttctaaaag agaagtccaa    180

tgtaatttta ctgaaaaaaa ttataccttg attccagcag atatcaagaa agatgttact    240

atacttgatc tcagttataa ccaaattact cttaatggta cagacacaag agttctacag    300

acatactttt tactcacaga gctctatttg attgagaaca aggttactat cttacataat    360

aacggttttg gtaacctctc cagtctagaa attttaaata tctgtagaaa ctccatctat    420

gtaattcaac agggtgcatt tttaggctta aataaactaa aacagttata tctctgccaa    480

aacaaaatag aacaactgaa tgctgatgta tttgtgcctc taagaagcct aaaacttctg    540

aatctgcaag gcaatttgat tagctatttg gatgtaccac cactatttca tctggaatta    600

ataactttat atggaaacct atggaactgc tcttgcagtc tatttaattt gcagaactgg    660

ttgaacacat caaatgtgac attagaaaat gagaacatca ccatgtgtag ctaccccaac    720

agcctgcaga gctacaatat caaaacagta cctcataagg ctgaatgcca ctcaaaattt    780

ccttcatcag taactgaaga tctttatatt cattttcagc ccatcagcaa ttcaatattt    840

aatagctctt cgaacaactt aacaagaaat tcagaacatg aacctcttgg aaaaagttgg    900

gcttttcttg ttggtgttgt tgtcactgta ctgacgactt cacttctcat ttttattgct    960

atcaaatgcc caatatggta caatattctg cttagttata atcatcatcg cctggaagag   1020

catgaagcag aaacctatga agatggtttt actggaaatc caagctctct ttcacagata   1080

ccagaaacaa actctgaaga aactacagta atatttgaac aattacattc atttgtggta   1140

gatgatgatg gatttattga agacaaatat atagatatcc atgaattatg tgaagaaaat   1200

taatttcttt caaagtttgc tttttaaagc aaagttatca gctcactcag tttagatatg   1260

gagattttgc tatgtgacat aacaaaatac agctggcagg cattcatatt aatgacaaca   1320

tacatgaata tcataaaatt atgttctttg cattatattg agcaagcagg ttcaaataca   1380

gtaactgaca ctcctcggta gttgacagtt acatagtcta caatactagc actactattc   1440

ttagcagtgc ttgggtgacc atacgaacta gtaaaaaggt ctaaattatt catgaattaa   1500

aatgaatgga ttctcatatt aacacaggta tttgacataa tatgtattaa gttatactaa   1560

tgtttcaatc agtaaagaaa taaaagttta ggatttatta atatatggaa gtcaaagtga   1620

ggaacagaga tagcttaaat aatacactaa gattgatttt atgctcccag aataaaatca   1680

tagagttgga aaatattttt ttgaaatgct tcctgaaata gcacaataaa tttcccttaa   1740

aatttcatag caatttaaag cacaagcaca atgttcaggc ataatcccta ataagtcact   1800

attgattctg gttataaaga aaggctgtca ccataatgca ggatcactac agtttaatgt   1860

catactggct tccaaagtgg gcatcacaat tatctataaa tcttgtttta aaaatacata   1920

tttctacctc tctctgggag atttttattc aaattggtct gtgctgacac taaggaatct   1980

tcatgtggtc catggacagc tatttctatc tattcagtag atagagcaat gtttcccaaa   2040

ttgtttttct agaatactaa tttccagaga gacattcaca agtatttaca gaagaagaag   2100

gaggtacatg gtcaaattac tacaggaaaa actagtagtt taaacaaggt gaaacaagat   2160

tctttttctt tttttttttt ttttttttga gacaaagtct cgcactgtct cccaggctgg   2220

actgcagcag cgcagtctca gatcactgca acctccgcct cctgggttca agcaattctt   2280

ctgactcagc ctcccgagta gctgggagta caggtgcaca ccaccatgcc tggctaattt   2340

ctgtattttt agtagagaca gggtttcacc atgttggcca ggctggtctc gaacgcctga   2400

cctcatgatc tacccgcctc ggcctcccaa agtgctggga ttacaggcat ggagcaccgt   2460

gcctggccaa gattctttac aataggattt atgtaaaact taactaagct aaactgctct   2520

ctgattattc aagagcaaag tattaaaaat ttctcgaact tacttgacaa caaaacccat   2580

tctttcagtt acatctacta agagctcgta gttcaataac attccaaaga acgtagtttg   2640

gaaaacactg gcctatcggc tgtaatagga agggtctaaa gaaaattatt tgctgagtcc   2700

tcataatcaa ttggctataa tcacaattta ataatttatc aatgcaaaca gtacattaaa   2760

aactgtagca caatctataa tttttacctt catatgcaga gaaattaaga atttacatct   2820

tttacaaata tgtgtatctc tgaaataatg aaatatattg atgggtgaaa taatatttct   2880

ggtattttct tcattataac acgtggaatg ggacagtggc tagaggtatg gatggagcaa   2940

ggtcaaatat gagctgatgg agctgggcgc taaataaggg tataatatgc tacttctgtg   3000

tatgttgtgt atggtatagt atgctatttc tgtgtatgtt caaattgttt atgtatataa   3060

taaagtttta aaaatttgta tgtacttgac aattccttag aaaaaagagg ctaaaataaa   3120

atagatctac gtcataaaaa aaaaaaaaaa aaaaaaaaaa                         3160


<210>  894
<211>  370
<212>  PRT
<213>  Homosapiens

<400>  894

Met Lys Val Thr Gly Ile Thr Ile Leu Phe Trp Pro Leu Ser Met Ile 
1               5                   10                  15      


Leu Leu Ser Asp Lys Ile Gln Ser Ser Lys Arg Glu Val Gln Cys Asn 
            20                  25                  30          


Phe Thr Glu Lys Asn Tyr Thr Leu Ile Pro Ala Asp Ile Lys Lys Asp 
        35                  40                  45              


Val Thr Ile Leu Asp Leu Ser Tyr Asn Gln Ile Thr Leu Asn Gly Thr 
    50                  55                  60                  


Asp Thr Arg Val Leu Gln Thr Tyr Phe Leu Leu Thr Glu Leu Tyr Leu 
65                  70                  75                  80  


Ile Glu Asn Lys Val Thr Ile Leu His Asn Asn Gly Phe Gly Asn Leu 
                85                  90                  95      


Ser Ser Leu Glu Ile Leu Asn Ile Cys Arg Asn Ser Ile Tyr Val Ile 
            100                 105                 110         


Gln Gln Gly Ala Phe Leu Gly Leu Asn Lys Leu Lys Gln Leu Tyr Leu 
        115                 120                 125             


Cys Gln Asn Lys Ile Glu Gln Leu Asn Ala Asp Val Phe Val Pro Leu 
    130                 135                 140                 


Arg Ser Leu Lys Leu Leu Asn Leu Gln Gly Asn Leu Ile Ser Tyr Leu 
145                 150                 155                 160 


Asp Val Pro Pro Leu Phe His Leu Glu Leu Ile Thr Leu Tyr Gly Asn 
                165                 170                 175     


Leu Trp Asn Cys Ser Cys Ser Leu Phe Asn Leu Gln Asn Trp Leu Asn 
            180                 185                 190         


Thr Ser Asn Val Thr Leu Glu Asn Glu Asn Ile Thr Met Cys Ser Tyr 
        195                 200                 205             


Pro Asn Ser Leu Gln Ser Tyr Asn Ile Lys Thr Val Pro His Lys Ala 
    210                 215                 220                 


Glu Cys His Ser Lys Phe Pro Ser Ser Val Thr Glu Asp Leu Tyr Ile 
225                 230                 235                 240 


His Phe Gln Pro Ile Ser Asn Ser Ile Phe Asn Ser Ser Ser Asn Asn 
                245                 250                 255     


Leu Thr Arg Asn Ser Glu His Glu Pro Leu Gly Lys Ser Trp Ala Phe 
            260                 265                 270         


Leu Val Gly Val Val Val Thr Val Leu Thr Thr Ser Leu Leu Ile Phe 
        275                 280                 285             


Ile Ala Ile Lys Cys Pro Ile Trp Tyr Asn Ile Leu Leu Ser Tyr Asn 
    290                 295                 300                 


His His Arg Leu Glu Glu His Glu Ala Glu Thr Tyr Glu Asp Gly Phe 
305                 310                 315                 320 


Thr Gly Asn Pro Ser Ser Leu Ser Gln Ile Pro Glu Thr Asn Ser Glu 
                325                 330                 335     


Glu Thr Thr Val Ile Phe Glu Gln Leu His Ser Phe Val Val Asp Asp 
            340                 345                 350         


Asp Gly Phe Ile Glu Asp Lys Tyr Ile Asp Ile His Glu Leu Cys Glu 
        355                 360                 365             


Glu Asn 
    370 


<210>  895
<211>  2821
<212>  DNA
<213>  Homosapiens

<400>  895
ccacgcgtcc ggtgacggac ccccgccgcc cgcggctcgg gacccctgcc taccctcctt     60

cttgcccgcc gggctgtgga actagcgcgt gccccctcgc cggcctcgac gtctcccgtc    120

cgcccctcac tcgtggcagg gcgcagctcc tggtccgtca cctgcgcgcc gccccacgcg    180

gccgggctgc gggtctaggg ggtccgcgtc tccctggctt tccaagggct aatgccgtga    240

ttctagagcg gctgggcgtc tagggcctcg cttcaaggtt actgactttt tatgatgttt    300

ggtggctatg agactataga agcatacgaa gatgatcttt atcgagatga gtcatctagt    360

gaactgagtg ttgatagtga ggtggaattt caactctata gccaaattca ttatgcccaa    420

gatcttgatg atgtcatcag ggaggaagag catgaagaaa agaactctgg gaattcggaa    480

tcttcgagta gtaaaccaaa tcagaagaag ctaatcgtcc tttcagatag tgaggtcatc    540

cagctgtcag atgggtcaga ggtcatcact ttgtctgatg aagacagtat ttatagatgt    600

aaaggaaaga atgttagagt tcaagcacaa gaaaatgccc atggtctttc ttcttctctt    660

caatctaatg agctggttga taagaaatgc aagagtgata ttgagaagcc taaatctgaa    720

gagagatcag gtgtaatccg agaggtcatg attatagagg tcagttcaag tgaagaggaa    780

gagagcacca tttcagaagg tgataatgtg gaaagctgga tgctactggg atgtgaagta    840

gatgataaag atgatgatat ccttctcaac cttgtgggat gtgaaaactc tgttactgaa    900

ggagaagatg gtataaactg gtccatcagt gacaaagaca ttgaggccca gatagctaat    960

aaccgaacac ctggaagatg gacccagcgg tactattcag ccaacaaaaa cattatctgt   1020

agaaattgtg acaaacgtgg tcatttatca aaaaactgcc ccttaccacg aaaagttcgt   1080

cgctgcttcc tgtgctccag gagaggacat ctcctgtatt cctgtccagc ccccctttgc   1140

gaatactgtc ctgtgcctaa gatgttggac cactcatgtc ttttcagaca ttcctgggat   1200

aaacagtgtg accgatgtca tatgctaggc cactatacag atgcttgcac agaaatctgg   1260

aggcagtatc acctaacgac caaacctgga ccacccaaaa agccgaagac cccttcaaga   1320

ccatcagcct tagcatattg ctatcactgc gcgcaaaaag gccattatgg acacgaatgt   1380

ccagaaagag aagtgtatga cccgtctcca gtatctccat tcatctgcta ctatgatgac   1440

aaatatgaaa ttcaggagag agaaaagaga ctaaaacaaa aaataaaagt actcaagaaa   1500

aatggggtta tcccagagcc atccaagcta ccttatataa aagcagcaaa tgagaacccc   1560

caccatgata taaggaaggg ccgtgcctca tggaaaagca acaggtggcc tcaagaaaat   1620

aaagaaacac aaaaagaaat gaagaacaag aatagaaact gggagaagca caggaaggct   1680

gacagacatc gtgaagtgga tgaggatttt cccaggggcc ccaaaaccta ctcttctcct   1740

ggcagtttta aaacccagaa gccttctaag ccctttcacc gttcatcaca ttaccacacg   1800

tcaagagaag acaagtctcc caaggaaggc aagaggggca agcagaagaa aaaggagagg   1860

tgctgggaag atgatgacaa tgataactta tttcttatta agcagagaaa aaaaaagtct   1920

taagccgtca ggcagcctct gatgtggctt ttcattgttc atttggcctt tgtgtctata   1980

accttctggc actgtgttta ttatctatga ttaaataaag tgagtttttg gttttgtttt   2040

tttaatttca gccattccta gagttactga atatccatgg agatctcaat tctctgtgtc   2100

caacaggata ttaggtaaga aagtacaaag ataaacctgg acttctccta ttccaatatg   2160

tcatctttac tcagaatcct agggataggt agaagaattc atcttttcaa gaaagtgttt   2220

taaaaatact ttggaaaaaa aactgcatca aaggtaattt atcctcaaat taaatccttg   2280

caggaagaga aattaacact aagaaaaagt catcaatatt tttcaacttt tttttttttt   2340

ttttttactt tggaaaggac aataactata aacctatatc cagattttct ttctgctgaa   2400

gctgttgtca gaatcttcct ttggacaaaa catcactagc tgactataaa aacaaaagtg   2460

tcatcattga agccctgaag aggcagggaa ttgagcttca gcaaaataca ggaaaagaac   2520

tatccagtat aaatgtcaga agacagattt cctaaacaag taaaagagac atcaaaaatt   2580

ttaacataat cacaatgaaa tcatttttta ccacttttac agcggtgttt caagcggact   2640

gtcactcaga tctgcagaga tgaatattac tcaaaaaatt tttttgttct cttgcatttt   2700

tttcaactac cgcaaagcta tacagatttt tttgtacttg tggatctttt gtacttctca   2760

taacctaatg tcagactaag aaaaataaaa tatctgagag taaaaaaaaa aaaaaaaaaa   2820

a                                                                   2821


<210>  896
<211>  542
<212>  PRT
<213>  Homosapiens

<400>  896

Met Phe Gly Gly Tyr Glu Thr Ile Glu Ala Tyr Glu Asp Asp Leu Tyr 
1               5                   10                  15      


Arg Asp Glu Ser Ser Ser Glu Leu Ser Val Asp Ser Glu Val Glu Phe 
            20                  25                  30          


Gln Leu Tyr Ser Gln Ile His Tyr Ala Gln Asp Leu Asp Asp Val Ile 
        35                  40                  45              


Arg Glu Glu Glu His Glu Glu Lys Asn Ser Gly Asn Ser Glu Ser Ser 
    50                  55                  60                  


Ser Ser Lys Pro Asn Gln Lys Lys Leu Ile Val Leu Ser Asp Ser Glu 
65                  70                  75                  80  


Val Ile Gln Leu Ser Asp Gly Ser Glu Val Ile Thr Leu Ser Asp Glu 
                85                  90                  95      


Asp Ser Ile Tyr Arg Cys Lys Gly Lys Asn Val Arg Val Gln Ala Gln 
            100                 105                 110         


Glu Asn Ala His Gly Leu Ser Ser Ser Leu Gln Ser Asn Glu Leu Val 
        115                 120                 125             


Asp Lys Lys Cys Lys Ser Asp Ile Glu Lys Pro Lys Ser Glu Glu Arg 
    130                 135                 140                 


Ser Gly Val Ile Arg Glu Val Met Ile Ile Glu Val Ser Ser Ser Glu 
145                 150                 155                 160 


Glu Glu Glu Ser Thr Ile Ser Glu Gly Asp Asn Val Glu Ser Trp Met 
                165                 170                 175     


Leu Leu Gly Cys Glu Val Asp Asp Lys Asp Asp Asp Ile Leu Leu Asn 
            180                 185                 190         


Leu Val Gly Cys Glu Asn Ser Val Thr Glu Gly Glu Asp Gly Ile Asn 
        195                 200                 205             


Trp Ser Ile Ser Asp Lys Asp Ile Glu Ala Gln Ile Ala Asn Asn Arg 
    210                 215                 220                 


Thr Pro Gly Arg Trp Thr Gln Arg Tyr Tyr Ser Ala Asn Lys Asn Ile 
225                 230                 235                 240 


Ile Cys Arg Asn Cys Asp Lys Arg Gly His Leu Ser Lys Asn Cys Pro 
                245                 250                 255     


Leu Pro Arg Lys Val Arg Arg Cys Phe Leu Cys Ser Arg Arg Gly His 
            260                 265                 270         


Leu Leu Tyr Ser Cys Pro Ala Pro Leu Cys Glu Tyr Cys Pro Val Pro 
        275                 280                 285             


Lys Met Leu Asp His Ser Cys Leu Phe Arg His Ser Trp Asp Lys Gln 
    290                 295                 300                 


Cys Asp Arg Cys His Met Leu Gly His Tyr Thr Asp Ala Cys Thr Glu 
305                 310                 315                 320 


Ile Trp Arg Gln Tyr His Leu Thr Thr Lys Pro Gly Pro Pro Lys Lys 
                325                 330                 335     


Pro Lys Thr Pro Ser Arg Pro Ser Ala Leu Ala Tyr Cys Tyr His Cys 
            340                 345                 350         


Ala Gln Lys Gly His Tyr Gly His Glu Cys Pro Glu Arg Glu Val Tyr 
        355                 360                 365             


Asp Pro Ser Pro Val Ser Pro Phe Ile Cys Tyr Tyr Asp Asp Lys Tyr 
    370                 375                 380                 


Glu Ile Gln Glu Arg Glu Lys Arg Leu Lys Gln Lys Ile Lys Val Leu 
385                 390                 395                 400 


Lys Lys Asn Gly Val Ile Pro Glu Pro Ser Lys Leu Pro Tyr Ile Lys 
                405                 410                 415     


Ala Ala Asn Glu Asn Pro His His Asp Ile Arg Lys Gly Arg Ala Ser 
            420                 425                 430         


Trp Lys Ser Asn Arg Trp Pro Gln Glu Asn Lys Glu Thr Gln Lys Glu 
        435                 440                 445             


Met Lys Asn Lys Asn Arg Asn Trp Glu Lys His Arg Lys Ala Asp Arg 
    450                 455                 460                 


His Arg Glu Val Asp Glu Asp Phe Pro Arg Gly Pro Lys Thr Tyr Ser 
465                 470                 475                 480 


Ser Pro Gly Ser Phe Lys Thr Gln Lys Pro Ser Lys Pro Phe His Arg 
                485                 490                 495     


Ser Ser His Tyr His Thr Ser Arg Glu Asp Lys Ser Pro Lys Glu Gly 
            500                 505                 510         


Lys Arg Gly Lys Gln Lys Lys Lys Glu Arg Cys Trp Glu Asp Asp Asp 
        515                 520                 525             


Asn Asp Asn Leu Phe Leu Ile Lys Gln Arg Lys Lys Lys Ser 
    530                 535                 540         


<210>  897
<211>  1235
<212>  DNA
<213>  Homosapiens

<400>  897
gcttctgtac tgccaggtcc gggtcggcgg ctgcactgcg gatgagaccg gtgcgactca     60

tgaaggtgtt cgtcacccgc aggatacccg ccgagggtag ggtcgcgctc gcccgggcgg    120

cagactgtga ggtggagcag tgggactcgg atgagcccat ccctgccaag gagctagagc    180

gaggtgtggc gggggcccac ggcctgctct gcctcctctc cgaccacgtg gacaagagga    240

tcctggatgc tgcaggggcc aatctcaaag tcatcagcac catgtctgtg ggcatcgacc    300

acttggcttt ggatgaaatc aagaagcgtg ggatccgagt tggctacacc ccagatgtcc    360

tgacagatac caccgccgaa ctcgcagtct ccctgctact taccacctgc cgccggttgc    420

cggaggccat cgaggaagtg aagaatggtg gctggacctc gtggaagccc ctctggctgt    480

gtggctatgg actcacgcag agcactgtcg gcatcatcgg gctggggcgc ataggccagg    540

ccattgctcg gcgtctgaaa ccattcggtg tccagagatt tctgtacaca gggcgccagc    600

ccaggcctga ggaagcagca gaattccagg cagagtttgt gtctacccct gagctggctg    660

cccaatctga tttcatcgtc gtggcctgct ccttaacacc tgcaaccgag ggactctgca    720

acaaggactt cttccagaag atgaaggaaa cagctgtgtt catcaacatc agcaggggcg    780

acgtcgtaaa ccaggacgac ctgtaccagg ccttggccag tggtaagatt gcagctgctg    840

gactggatgt gacgagccca gaaccactgc ctacaaacca ccctctcctg accctgaaga    900

actgtgtgat tctgccccac attggcagtg ccacccacag aacccgcaac accatgtcct    960

tgttggcagc taacaacttg ctggctggcc tgagagggga gccgatgcct agtgaactca   1020

agctgtagcc aaacagtaga gatggagggc cgggaagcaa accgtgccct ggtattgtca   1080

gacacaccca ggcttgattt ggatccacag gcagagccaa gggaaggtgt gattctctga   1140

ggaaagagtg attctgatat atgtacttgt cacattggtg ttggacacat ttgcgccaaa   1200

agtatggtaa ttctattatt aaataattct ctgag                              1235


<210>  898
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  898

Met Arg Pro Val Arg Leu Met Lys Val Phe Val Thr Arg Arg Ile Pro 
1               5                   10                  15      


Ala Glu Gly Arg Val Ala Leu Ala Arg Ala Ala Asp Cys Glu Val Glu 
            20                  25                  30          


Gln Trp Asp Ser Asp Glu Pro Ile Pro Ala Lys Glu Leu Glu Arg Gly 
        35                  40                  45              


Val Ala Gly Ala His Gly Leu Leu Cys Leu Leu Ser Asp His Val Asp 
    50                  55                  60                  


Lys Arg Ile Leu Asp Ala Ala Gly Ala Asn Leu Lys Val Ile Ser Thr 
65                  70                  75                  80  


Met Ser Val Gly Ile Asp His Leu Ala Leu Asp Glu Ile Lys Lys Arg 
                85                  90                  95      


Gly Ile Arg Val Gly Tyr Thr Pro Asp Val Leu Thr Asp Thr Thr Ala 
            100                 105                 110         


Glu Leu Ala Val Ser Leu Leu Leu Thr Thr Cys Arg Arg Leu Pro Glu 
        115                 120                 125             


Ala Ile Glu Glu Val Lys Asn Gly Gly Trp Thr Ser Trp Lys Pro Leu 
    130                 135                 140                 


Trp Leu Cys Gly Tyr Gly Leu Thr Gln Ser Thr Val Gly Ile Ile Gly 
145                 150                 155                 160 


Leu Gly Arg Ile Gly Gln Ala Ile Ala Arg Arg Leu Lys Pro Phe Gly 
                165                 170                 175     


Val Gln Arg Phe Leu Tyr Thr Gly Arg Gln Pro Arg Pro Glu Glu Ala 
            180                 185                 190         


Ala Glu Phe Gln Ala Glu Phe Val Ser Thr Pro Glu Leu Ala Ala Gln 
        195                 200                 205             


Ser Asp Phe Ile Val Val Ala Cys Ser Leu Thr Pro Ala Thr Glu Gly 
    210                 215                 220                 


Leu Cys Asn Lys Asp Phe Phe Gln Lys Met Lys Glu Thr Ala Val Phe 
225                 230                 235                 240 


Ile Asn Ile Ser Arg Gly Asp Val Val Asn Gln Asp Asp Leu Tyr Gln 
                245                 250                 255     


Ala Leu Ala Ser Gly Lys Ile Ala Ala Ala Gly Leu Asp Val Thr Ser 
            260                 265                 270         


Pro Glu Pro Leu Pro Thr Asn His Pro Leu Leu Thr Leu Lys Asn Cys 
        275                 280                 285             


Val Ile Leu Pro His Ile Gly Ser Ala Thr His Arg Thr Arg Asn Thr 
    290                 295                 300                 


Met Ser Leu Leu Ala Ala Asn Asn Leu Leu Ala Gly Leu Arg Gly Glu 
305                 310                 315                 320 


Pro Met Pro Ser Glu Leu Lys Leu 
                325             


<210>  899
<211>  4631
<212>  DNA
<213>  Homosapiens

<400>  899
gcgaactggc tggaggagct aggggactag aggcggggtg ggaggggggc gggtggaagg     60

gggaggaagt cccgtaacgg agacgctggt caggacgttc ccacctcctc tgacactgcc    120

gagtccgatc ggagaggggt caccgcctcc ttcagcgagg aggagggggg cggagcccga    180

ctcaggatca tggattttcc tggtcacttt gaacaaatct tccagcagct gaactaccag    240

agacttcatg gccagctctg tgattgtgtc attgtagtgg ggaatagaca ctttaaagcc    300

caccgctccg tgctggcagc atgcagcacg catttccgag ccctgttctc agtggcagaa    360

ggagatcaga ccatgaacat gatccagctg gatagcgagg tggtgacagc agaggccttt    420

gctgcactga ttgacatgat gtatacctcc accctcatgc tgggggagag caatgtaatg    480

gatgtcttat tggcagcctc tcacctgcat ttgaactctg ttgttaaggc atgtaaacat    540

tacttaacga caaggacgct gcccatgtct ccccccagtg agcgcgttca ggagcagagc    600

gcccgcatgc agcgctcctt tatgctacag cagctgggac taagcatcgt gagctcagcc    660

ctcaattcca gccagaatgg cgaggagcag ccagccccca tgagctcttc catgcgcagt    720

aacctggatc agcgcacgcc cttccccatg agacgccttc ataagcgcaa gcagtctgca    780

gaggagcggg ccaggcagcg cctccgaccc tccatagatg agtctgccat ttcagatgtt    840

acaccggaga atgggccttc aggggttcat tctcgggagg agttcttttc accagattct    900

ctgaaaattg tggataatcc taaagctgac ggaatgactg ataaccagga agatagtgcg    960

atcatgtttg atcagtcttt tggcactcaa gaagatgccc aggtgcccag ccagtctgat   1020

aacagtgctg gcaacatggc acagttgtcc atggcctctc gtgcaactca ggttgagact   1080

agttttgatc aggaagctgc acctgagaaa agtagttttc agtgtgaaaa ccctgaggtt   1140

ggccttggtg agaaggagca catgagagtg gtggttaaat ctgagcctct gagctcacct   1200

gagcctcagg atgaagtgag cgatgtgacc tcacaagcag aaggcagcga gtctgtggaa   1260

gtggaaggag ttgtggtcag tgccgagaag atagacctca gccctgaaag cagtgatcgg   1320

agtttttcag atccccagtc tagcacagac agggtaggtg atatccatat tttggaagtc   1380

acaaataacc tagagcataa gtccactttt agtatttcga attttcttaa caagagcaga   1440

ggaaataact ttactgcaaa tcagaacaat gatgataata ttccaaacac cactagtgac   1500

tgcaggctgg agagtgaggc cccctatttg ttgagtccag aggctgggcc tgcaggtggg   1560

ccctcctctg cccctggctc ccatgtagag aacccattta gtgaacctgc agactcccac   1620

ttcgtcaggc ctatgcagga ggtgatgggc ctgccgtgtg tgcagacttc aggctaccaa   1680

ggaggagaac agtttgggat ggacttttcc aggtctggtt tgggcctcca ctcctccttc   1740

tccagggtaa tgataggttc cccaagggga ggagccagta actttcctta ctaccgccgc   1800

atagctccca aaatgccagt tgtaacttcc gtcaggagct cacagatccc agaaaactct   1860

accagttctc agctaatgat gaatggagct acgtcctcat ttgaaaatgg ccatccttcc   1920

cagcctggcc ctccacagtt gaccagggca tctgcagatg ttctgtcaaa gtgcaagaag   1980

gccttatcag agcacaatgt tttggttgta gagggagctc gcaagtatgc ctgcaaaatc   2040

tgctgcaaaa cttttctgac tttgacagat tgcaagaagc acatccgtgt tcacacaggt   2100

gaaaagcctt acgcctgcct gaagtgtggc aagaggttta gtcagtccag ccacctgtat   2160

aagcactcaa agactacctg cctgcgctgg cagagcagca atcttcccag cactttgctc   2220

tagctgtttg tccttacaag acaacgctga ggccagttgt cagactgaat ttcttttggt   2280

aagcagttaa tgcctttggg ttcgaggctt ccagctgccc agtggctctt aaacagttta   2340

gcaactaata accggagaac taacatgtag tatttgtgct gctgcatttc tgagtgaagt   2400

gcacgtcttg ggaaagggat gcaatccctg aaaccaggtg cttccttggg gttgagtaat   2460

gcagtcagaa agtagtttgt aattgatatt aaaagtggca catttaaaaa tttaaaaatt   2520

gaagtgcaaa aaaaattttt tagcaatttt tgtaaaactg tgtagcattt aaatttccta   2580

taccttctga tgggagtatt atatccctgt atagtgatgc aaaatgcact tatgtgtaac   2640

cagtggtgat ttggtgcctg tcttaaagga aggcctttga ggacacacct gtctgccaca   2700

aatgctttaa agtgtatcat gagctagtcc taggcctcaa agtactgtat tttttatttt   2760

tacctgattt gcagtcataa acactgcact ttggtgctga cactgggtcc agagtgagca   2820

ttctcttgga ctattagatg tatatacttt tgaatacatc actgttggat agatgtttta   2880

acagtttttt ctggtttaaa aaccaaattg taaatggagt gtgtacttgt agagagtgac   2940

aaggtattgt ttgtttccct atgtgctgtt tgagcagtat tttaaccaac ttgtattaca   3000

gatgttacag ttccatgtta ggaagtcaga aaagacttgt gtttgtcttt gttctgctga   3060

tgtggagtca tgttttgtgg ggtcttccat ggcacattta cctgttgctc cgtccagatg   3120

ttgagggcca gtctaggctg acacatccta cccgaggaca agcctgttct ccatttcttc   3180

actctcccct ccccatatag caactctccc aggtttagat taccgttttc gacgacagat   3240

taaccaaaaa tgccccacac aggttttatt actgttatat actatacttt taacagtaca   3300

gaccctaaat tttattattt gttgctcccc caatctgata ccaaatgttt aaagttgttt   3360

gaaatccaaa catggtagtg ttcatgggta aatattttct aggctatgta agagttagca   3420

gcccatagca tagaagtaat caagtagcat ctgagactgt tggaggcact agggcctctc   3480

tgggccctac agcctcactt ccccagcctc accttgctgt cctctgacac tgccatcagg   3540

gctgttagtg gcacctgtat gaggccaagt gtgcgtccag gggaacagca caggttaatg   3600

cgtctcccta gaactcatga agtcagttta attcatgcat gaacatgagt tcattttatg   3660

ttttatatag ctttcttaga cataccaaac catcattcat aaatcagata aattattcag   3720

tttttgtgtt tagaaagcta agtatgtgta gctggaaaca aaaatgagcg tgttttctct   3780

cctgttaatc tagagtgtgc agttacacat gtgtggataa tttcatgttc caggggcgct   3840

tggcatctcc catggactga ttcccaggaa gaaaagccca aagggaaacc cacgattcct   3900

ttcgagtaga tgtgggaaag agcccattgg aggatatgag gtcctgtgaa attcagttgt   3960

gtgtgtggct ccttgttagc agtcatgttg acatggtgtt aggaggctcc ccatccaccc   4020

tttacatgat gtagggacca gtgtcttgtg agattaacct tgggacacag tgggttagcc   4080

tggagaaaat gagaggccct gcctggaccc agggagagga gccagtgaca caggcagagc   4140

ggtgcagccc tccttccctt ccatttggag gaggtggtgc caggagcctg cccgcttacc   4200

tctgctgaag cataagtgga ctttgctttt ggggcttatc tctgatacat gctggagccc   4260

tgcctctcca ctgctagatg gaacctggaa tctctcatct acctcttagt ctgtcagttt   4320

ctacgtgtga gaagcaagct tgtgggccag tgtccttgta catgctgtag cacttaaaaa   4380

ataattccag ggttccctgg aaaaccagtc ccagggttcc tatgatctgt agtttctacc   4440

tggattataa ctggttttgg gtacctgaat tttgattggt tagccttaat tatagtctgg   4500

cgtgatcatg tagaatcttt tctggtgaac agatcataaa gttctatcaa ggagttctat   4560

caaggcatcc atgtcagtgg tgctatgctg gttacaactt gagatttttg aaataaaaaa   4620

tttgtcatat t                                                        4631


<210>  900
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  900

Met Asp Phe Pro Gly His Phe Glu Gln Ile Phe Gln Gln Leu Asn Tyr 
1               5                   10                  15      


Gln Arg Leu His Gly Gln Leu Cys Asp Cys Val Ile Val Val Gly Asn 
            20                  25                  30          


Arg His Phe Lys Ala His Arg Ser Val Leu Ala Ala Cys Ser Thr His 
        35                  40                  45              


Phe Arg Ala Leu Phe Ser Val Ala Glu Gly Asp Gln Thr Met Asn Met 
    50                  55                  60                  


Ile Gln Leu Asp Ser Glu Val Val Thr Ala Glu Ala Phe Ala Ala Leu 
65                  70                  75                  80  


Ile Asp Met Met Tyr Thr Ser Thr Leu Met Leu Gly Glu Ser Asn Val 
                85                  90                  95      


Met Asp Val Leu Leu Ala Ala Ser His Leu His Leu Asn Ser Val Val 
            100                 105                 110         


Lys Ala Cys Lys His Tyr Leu Thr Thr Arg Thr Leu Pro Met Ser Pro 
        115                 120                 125             


Pro Ser Glu Arg Val Gln Glu Gln Ser Ala Arg Met Gln Arg Ser Phe 
    130                 135                 140                 


Met Leu Gln Gln Leu Gly Leu Ser Ile Val Ser Ser Ala Leu Asn Ser 
145                 150                 155                 160 


Ser Gln Asn Gly Glu Glu Gln Pro Ala Pro Met Ser Ser Ser Met Arg 
                165                 170                 175     


Ser Asn Leu Asp Gln Arg Thr Pro Phe Pro Met Arg Arg Leu His Lys 
            180                 185                 190         


Arg Lys Gln Ser Ala Glu Glu Arg Ala Arg Gln Arg Leu Arg Pro Ser 
        195                 200                 205             


Ile Asp Glu Ser Ala Ile Ser Asp Val Thr Pro Glu Asn Gly Pro Ser 
    210                 215                 220                 


Gly Val His Ser Arg Glu Glu Phe Phe Ser Pro Asp Ser Leu Lys Ile 
225                 230                 235                 240 


Val Asp Asn Pro Lys Ala Asp Gly Met Thr Asp Asn Gln Glu Asp Ser 
                245                 250                 255     


Ala Ile Met Phe Asp Gln Ser Phe Gly Thr Gln Glu Asp Ala Gln Val 
            260                 265                 270         


Pro Ser Gln Ser Asp Asn Ser Ala Gly Asn Met Ala Gln Leu Ser Met 
        275                 280                 285             


Ala Ser Arg Ala Thr Gln Val Glu Thr Ser Phe Asp Gln Glu Ala Ala 
    290                 295                 300                 


Pro Glu Lys Ser Ser Phe Gln Cys Glu Asn Pro Glu Val Gly Leu Gly 
305                 310                 315                 320 


Glu Lys Glu His Met Arg Val Val Val Lys Ser Glu Pro Leu Ser Ser 
                325                 330                 335     


Pro Glu Pro Gln Asp Glu Val Ser Asp Val Thr Ser Gln Ala Glu Gly 
            340                 345                 350         


Ser Glu Ser Val Glu Val Glu Gly Val Val Val Ser Ala Glu Lys Ile 
        355                 360                 365             


Asp Leu Ser Pro Glu Ser Ser Asp Arg Ser Phe Ser Asp Pro Gln Ser 
    370                 375                 380                 


Ser Thr Asp Arg Val Gly Asp Ile His Ile Leu Glu Val Thr Asn Asn 
385                 390                 395                 400 


Leu Glu His Lys Ser Thr Phe Ser Ile Ser Asn Phe Leu Asn Lys Ser 
                405                 410                 415     


Arg Gly Asn Asn Phe Thr Ala Asn Gln Asn Asn Asp Asp Asn Ile Pro 
            420                 425                 430         


Asn Thr Thr Ser Asp Cys Arg Leu Glu Ser Glu Ala Pro Tyr Leu Leu 
        435                 440                 445             


Ser Pro Glu Ala Gly Pro Ala Gly Gly Pro Ser Ser Ala Pro Gly Ser 
    450                 455                 460                 


His Val Glu Asn Pro Phe Ser Glu Pro Ala Asp Ser His Phe Val Arg 
465                 470                 475                 480 


Pro Met Gln Glu Val Met Gly Leu Pro Cys Val Gln Thr Ser Gly Tyr 
                485                 490                 495     


Gln Gly Gly Glu Gln Phe Gly Met Asp Phe Ser Arg Ser Gly Leu Gly 
            500                 505                 510         


Leu His Ser Ser Phe Ser Arg Val Met Ile Gly Ser Pro Arg Gly Gly 
        515                 520                 525             


Ala Ser Asn Phe Pro Tyr Tyr Arg Arg Ile Ala Pro Lys Met Pro Val 
    530                 535                 540                 


Val Thr Ser Val Arg Ser Ser Gln Ile Pro Glu Asn Ser Thr Ser Ser 
545                 550                 555                 560 


Gln Leu Met Met Asn Gly Ala Thr Ser Ser Phe Glu Asn Gly His Pro 
                565                 570                 575     


Ser Gln Pro Gly Pro Pro Gln Leu Thr Arg Ala Ser Ala Asp Val Leu 
            580                 585                 590         


Ser Lys Cys Lys Lys Ala Leu Ser Glu His Asn Val Leu Val Val Glu 
        595                 600                 605             


Gly Ala Arg Lys Tyr Ala Cys Lys Ile Cys Cys Lys Thr Phe Leu Thr 
    610                 615                 620                 


Leu Thr Asp Cys Lys Lys His Ile Arg Val His Thr Gly Glu Lys Pro 
625                 630                 635                 640 


Tyr Ala Cys Leu Lys Cys Gly Lys Arg Phe Ser Gln Ser Ser His Leu 
                645                 650                 655     


Tyr Lys His Ser Lys Thr Thr Cys Leu Arg Trp Gln Ser Ser Asn Leu 
            660                 665                 670         


Pro Ser Thr Leu Leu 
        675         


<210>  901
<211>  762
<212>  DNA
<213>  Homosapiens

<400>  901
atgaggcggg tgaccctgtt cctgaacggc agccccaaga acggaaaggt ggttgctgca     60

tatggaactt catgtgattt gctgtctgtg gccagcagta aactcggcat aaaagccacc    120

agtgtgtata atgggaaagg tggactgaat gatgatattg ttttgatcag ggatgatgat    180

gttttatttg tgtgtgaggg agagccattt attgatcctc agacagattc taagcctcct    240

gaaggattgc taggattcca cacagactgg ctaacattac atgttggagg gcagtacttt    300

acaactacct ggagcacttt agtgaataaa gaacctgaca ttatgctggc ccacatgttt    360

aaggacaaag gtgtctgggg aaataagcaa gatcatagag gagctttctt aattgaccaa    420

agtcctgagt actttgaacc cattttgaac tacttgcgtc atggacagct cattgtaaat    480

gatggcattg atttattggc caatttagaa ggtgctaatc tgaaaggtgt ggatatggaa    540

ggaagtcaga tgacaggaat taacctgaga gtggctacct taaaaaatgc aaagttgaag    600

aactgtagcc tcagaggagc aactctgaca ggaactgatt tagagaactg tgatctgtct    660

gggtgtgatc ttcaagaagc caacctgaga gggtccaacg tgaggggagc tagatttgaa    720

gagatgctga caccactaca catgtcgcaa agtgtcagat ga                       762


<210>  902
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  902

Met Arg Arg Val Thr Leu Phe Leu Asn Gly Ser Pro Lys Asn Gly Lys 
1               5                   10                  15      


Val Val Ala Ala Tyr Gly Thr Ser Cys Asp Leu Leu Ser Val Ala Ser 
            20                  25                  30          


Ser Lys Leu Gly Ile Lys Ala Thr Ser Val Tyr Asn Gly Lys Gly Gly 
        35                  40                  45              


Leu Asn Asp Asp Ile Val Leu Ile Arg Asp Asp Asp Val Leu Phe Val 
    50                  55                  60                  


Cys Glu Gly Glu Pro Phe Ile Asp Pro Gln Thr Asp Ser Lys Pro Pro 
65                  70                  75                  80  


Glu Gly Leu Leu Gly Phe His Thr Asp Trp Leu Thr Leu His Val Gly 
                85                  90                  95      


Gly Gln Tyr Phe Thr Thr Thr Trp Ser Thr Leu Val Asn Lys Glu Pro 
            100                 105                 110         


Asp Ile Met Leu Ala His Met Phe Lys Asp Lys Gly Val Trp Gly Asn 
        115                 120                 125             


Lys Gln Asp His Arg Gly Ala Phe Leu Ile Asp Gln Ser Pro Glu Tyr 
    130                 135                 140                 


Phe Glu Pro Ile Leu Asn Tyr Leu Arg His Gly Gln Leu Ile Val Asn 
145                 150                 155                 160 


Asp Gly Ile Asp Leu Leu Ala Asn Leu Glu Gly Ala Asn Leu Lys Gly 
                165                 170                 175     


Val Asp Met Glu Gly Ser Gln Met Thr Gly Ile Asn Leu Arg Val Ala 
            180                 185                 190         


Thr Leu Lys Asn Ala Lys Leu Lys Asn Cys Ser Leu Arg Gly Ala Thr 
        195                 200                 205             


Leu Thr Gly Thr Asp Leu Glu Asn Cys Asp Leu Ser Gly Cys Asp Leu 
    210                 215                 220                 


Gln Glu Ala Asn Leu Arg Gly Ser Asn Val Arg Gly Ala Arg Phe Glu 
225                 230                 235                 240 


Glu Met Leu Thr Pro Leu His Met Ser Gln Ser Val Arg 
                245                 250             


<210>  903
<211>  1854
<212>  DNA
<213>  Homosapiens

<400>  903
cttttccggc ccgcagcgcg gcctgggctc ccgcgtgttt aaaagtgcgc ttgtggctgc     60

tgctgtctta actcctgtgc ttggcggaca gacaggcgag atggcggcgg aggtgttgcc    120

gagtgcgagg tggcagtatt gtggggcgcc cgacgggagc cagagagctg tactggtcca    180

gttctccaac gggaagctac agagtccagg caacatgcgc tttaccttgt atgagaacaa    240

agattccacc aaccccagga agaggaatca acggatcctg gcagctgaaa cagataggct    300

ctcctatgtg ggaaacaatt ttgggactgg agccctcaaa tgcaacactt tgtgcaggca    360

ctttgtggga attttgaaca agacctctgg ccaaatggaa gtatatgatg ctgaattgtt    420

caacatgcag ccactatttt cagatgtatc agttgagagt gaactggcgc tagagagtca    480

gaccaaaact tacagagaaa agatggattc ttgtattgaa gcctttggta ccaccaaaca    540

gaagcgagct ctgaacacca ggagaatgaa cagagttggc aatgaatctt tgaatcgtgc    600

agtggctaaa gctgcagaga ctatcattga tacgaagggt gtgactgctc tggtcagcga    660

tgctatccac aatgacttgc aagatgactc cctctacctt cctccctgct atgatgatgc    720

agccaagcct gaagacgtgt ataaatttga agatcttctt tcccctgcgg agtatgaagc    780

tcttcagagc ccatctgaag ctttcaggaa cgtcacgtca gaagaaatac tgaagatgat    840

tgaggagaac agccattgca cctttgtcat agaagcgttg aagtctttgc catcagatgt    900

ggagagccga gaccgccagg cccgatgcat atggtttctg gataccctca tcaaatttcg    960

agctcatagg gtagttaagc ggaaaagtgc tctgggacct ggagttcccc acatcatcaa   1020

caccaaactg ctgaagcact ttacttgctt gacctacaac aatggcagat tacggaactt   1080

aatttcggat tctatgaagg cgaagattac tgcatatgtg atcatacttg ccttgcacat   1140

acatgacttc caaattgacc tgacagtgtt acagagggac ttgaagctca gtgagaaaag   1200

gatgatggag atagccaaag ccatgaggct gaagatctcc aaaagaaggg tgtctgtggc   1260

cgccggcagt gaagaagatc acaaactggg caccctgtcc ctcccgctgc ctccagccca   1320

gacctcagac cgcctggcaa agcggaggaa gattacctag acgcatgctt tccagacagg   1380

gcgttttggc tgcatcacag ccactggctg gtcctattca tttccatttt tatgtatgtt   1440

ttgaaaagaa aaggtccggg gatggtggct cacacctgaa atcccagcac tttgggaggc   1500

cgaggcagga agatcattga gctcaggagt ttgaaaccag tctggacaac atggggagac   1560

cccatctcta ccggaggaaa aaaaaaagag tcaggcctgg tggtgtgcgc ctgtaatccc   1620

agctactcgg gaggctgagg caggacgatt acttgagctt gggaaatcaa ggttgcagtg   1680

agctatgatt gtgtggccac actccatcct gggtcacaga gtgagacctt gtctcaaaaa   1740

agtaacataa ggaaaaaaga agccttgctt tagcacaggt atgaagccag aagccagcat   1800

ctcaactgtg cttgtcttat gcagaaatat aaagcgatgg ccaggttgga cttc         1854


<210>  904
<211>  419
<212>  PRT
<213>  Homosapiens

<400>  904

Met Ala Ala Glu Val Leu Pro Ser Ala Arg Trp Gln Tyr Cys Gly Ala 
1               5                   10                  15      


Pro Asp Gly Ser Gln Arg Ala Val Leu Val Gln Phe Ser Asn Gly Lys 
            20                  25                  30          


Leu Gln Ser Pro Gly Asn Met Arg Phe Thr Leu Tyr Glu Asn Lys Asp 
        35                  40                  45              


Ser Thr Asn Pro Arg Lys Arg Asn Gln Arg Ile Leu Ala Ala Glu Thr 
    50                  55                  60                  


Asp Arg Leu Ser Tyr Val Gly Asn Asn Phe Gly Thr Gly Ala Leu Lys 
65                  70                  75                  80  


Cys Asn Thr Leu Cys Arg His Phe Val Gly Ile Leu Asn Lys Thr Ser 
                85                  90                  95      


Gly Gln Met Glu Val Tyr Asp Ala Glu Leu Phe Asn Met Gln Pro Leu 
            100                 105                 110         


Phe Ser Asp Val Ser Val Glu Ser Glu Leu Ala Leu Glu Ser Gln Thr 
        115                 120                 125             


Lys Thr Tyr Arg Glu Lys Met Asp Ser Cys Ile Glu Ala Phe Gly Thr 
    130                 135                 140                 


Thr Lys Gln Lys Arg Ala Leu Asn Thr Arg Arg Met Asn Arg Val Gly 
145                 150                 155                 160 


Asn Glu Ser Leu Asn Arg Ala Val Ala Lys Ala Ala Glu Thr Ile Ile 
                165                 170                 175     


Asp Thr Lys Gly Val Thr Ala Leu Val Ser Asp Ala Ile His Asn Asp 
            180                 185                 190         


Leu Gln Asp Asp Ser Leu Tyr Leu Pro Pro Cys Tyr Asp Asp Ala Ala 
        195                 200                 205             


Lys Pro Glu Asp Val Tyr Lys Phe Glu Asp Leu Leu Ser Pro Ala Glu 
    210                 215                 220                 


Tyr Glu Ala Leu Gln Ser Pro Ser Glu Ala Phe Arg Asn Val Thr Ser 
225                 230                 235                 240 


Glu Glu Ile Leu Lys Met Ile Glu Glu Asn Ser His Cys Thr Phe Val 
                245                 250                 255     


Ile Glu Ala Leu Lys Ser Leu Pro Ser Asp Val Glu Ser Arg Asp Arg 
            260                 265                 270         


Gln Ala Arg Cys Ile Trp Phe Leu Asp Thr Leu Ile Lys Phe Arg Ala 
        275                 280                 285             


His Arg Val Val Lys Arg Lys Ser Ala Leu Gly Pro Gly Val Pro His 
    290                 295                 300                 


Ile Ile Asn Thr Lys Leu Leu Lys His Phe Thr Cys Leu Thr Tyr Asn 
305                 310                 315                 320 


Asn Gly Arg Leu Arg Asn Leu Ile Ser Asp Ser Met Lys Ala Lys Ile 
                325                 330                 335     


Thr Ala Tyr Val Ile Ile Leu Ala Leu His Ile His Asp Phe Gln Ile 
            340                 345                 350         


Asp Leu Thr Val Leu Gln Arg Asp Leu Lys Leu Ser Glu Lys Arg Met 
        355                 360                 365             


Met Glu Ile Ala Lys Ala Met Arg Leu Lys Ile Ser Lys Arg Arg Val 
    370                 375                 380                 


Ser Val Ala Ala Gly Ser Glu Glu Asp His Lys Leu Gly Thr Leu Ser 
385                 390                 395                 400 


Leu Pro Leu Pro Pro Ala Gln Thr Ser Asp Arg Leu Ala Lys Arg Arg 
                405                 410                 415     


Lys Ile Thr 
            


<210>  905
<211>  3181
<212>  DNA
<213>  Homosapiens

<400>  905
gcgcgaggat gtgatctcct ccatacggaa ctttctcatc tacgtggccc tcctgcgagt     60

cagtgagtgt ctcccgggct gtgactgtga gaccagcggg gagctcaccg acgggcaccc    120

cttaactcta aggggtcatc ggggccttcg aactgagctg aacgctccat ttatcttaaa    180

gaaattggac agcatatgaa gacaggacat cacatatgaa tgcacgatat gaagagcctg    240

gttacagttt cgactcctct ctgcaagtga ataggcccag aaaggtgtga ccatggaggc    300

tggtggcctc cccttggagc tgtggcgcat gatcttagcc tacttgcacc ttcccgacct    360

gggccgctgc agcctggtat gcagggcctg gtatgaactg atcctcagtc tcgacagcac    420

ccgctggcgg cagctgtgtc tgggttgcac cgagtgccgc catcccaatt ggcccaacca    480

gccagatgtg gagcctgagt cttggagaga agccttcaag cagcattacc ttgcatccaa    540

gacatggacc aagaatgcct tggacttgga gtcttccatc tgcttttctc tattccgccg    600

gaggagggaa cgacgtaccc tgagtgttgg gccaggccgt gagtttgaca gcctgggcag    660

tgccttggcc atggccagcc tgtatgaccg aattgtgctc ttcccaggtg tgtacgaaga    720

gcaaggtgaa atcatcttga aggtgcctgt ggagattgta gggcagggga agttgggtga    780

agtggccctg ctggccagca ttgatcagca ctgctcaacc acacgcctgt gcaacctcgt    840

cttcacgcca gcctggttct cacccatcat gtataagaca acatcaggtc acgtccagtt    900

tgacaactgc aactttgaga acgggcacat ccaggtccat ggcccgggta cttgccaagt    960

gaagttctgt accttcaaaa acacccatat cttcctgcac aacgtgcccc tgtgtgtcct   1020

ggaaaactgt gaatttgtgg gcagtgaaaa caactctgtg actgttgagg gtcacccatc   1080

tgcagataag aactgggcct acaagtatct actagggctt atcaagtcct cacccacttt   1140

tctccccaca gaggactctg actttttaat gtccctggac ctagagagcc gggaccaggc   1200

ctggagccca aagacctgtg acattgttat cgagggcagc cagagcccta ccagcccagc   1260

ctctagctcc ccaaagccag gctccaaggc tggctcacag gaggcagagg tgggtagtga   1320

tggtgaaagg gtggcccaga ccccggacag cagcgatgga ggcctgagtc ccagcggtga   1380

ggatgaagat gaggaccagc tgatgtacag actatcctac caagtgcagg gcccacgccc   1440

tgtattgggg ggctcatttc tgggcccacc tctaccagga gcatccattc agctgcccag   1500

ctgcctagtg ctgaactcac tgcagcagga gctgcagaag gataaggagg ccatggcact   1560

ggccaactcc gtgcagggct gcctcatccg caagtgcctc ttccgggacg ggaagggagg   1620

cgtcttcgtc tgctcccacg gcagagccaa gatggaagga aacatcttcc ggaacctgac   1680

ttacgcagtg cggtgtatac ataatagcaa gatcatcatg ctcaggaacg acatttaccg   1740

ctgccgagcg tcaggcatct ttcttcgctt ggagggcggt ggcttgattg ccggcaacaa   1800

catttaccac aatgcagagg ctggtgtaga catccggaaa aagtccaacc cactcatact   1860

gtgtaaccag atccaccatg gccttcgctc tggcattgtc gtccttggca atgggaaagg   1920

catcatccgg aacaatcaaa tcttttccaa taaggaggct ggcatttaca tcctgtacca   1980

cggaaacccc gttgtgagcg ggaaccacat cttcaagggc cgtgctgccg gcatagcagt   2040

gaatgagaac ggcaaaggcc tcatcacaga aaatgtcatc cgtgagaatc agtggggagg   2100

tgtggacatc cgccgtggag ggatccccgt tctcaggagt aacctcatct gctttggcta   2160

ttcagatggt gtggttgtgg gagacgaagg caaaggcctc atagaaggaa ataccatcta   2220

cgctaacaag ggctgtggtg tgtggatgat gtcgtccagc ctcccccatg tcaccagcaa   2280

ccacgtcagc tacaatggcc tgtatggagt ggcagtattt agccagaagg atggctccag   2340

cgagttacct cgaggccaca gggctcaaga gaacttcagc gaggatgggg acgccatcct   2400

ctgggagaca gagctggaga aggaggacga cccactgcgc cggcccatca ccatagctct   2460

tgttgagtct aacagtatta atcacaatgg agcctcagga ctctatgtcc agagcagcga   2520

ggcactgcat gtcatcacca atgtgatcca cgcgaatggg gacagaggca ttactgtggc   2580

ccagagcagc caacccaccc gagtggccaa caacagcatc tcctgcaacc ggcaaagtgg   2640

ggtcaaggtt gaggcccagt gcaaagtgga gctccggggc aatggtatct atgacaacag   2700

aggccacggc attatcacca agggcgacag caccatcgtc attgaaaacg atatcattgg   2760

caaccggggc agcgggctgc agctgctgcc caggtccgac actaaagtga gtatgtctgc   2820

atgtgtaata aagaaccgga tccactcgtt ccgggcctac ggcatcgccg tgcggggccg   2880

tgccaaggcc ctggtgcagg aaaacatcat cttccagggc aaaaccagta agaccatctt   2940

tcagcagatc tcaaacaacc gagaatgcat catgcaaaac aacaagttcc tggtcttcaa   3000

gaaaaagtct gatacgtggc gcctggtgaa cccaccagca cggccccacc ttgaaaattc   3060

tctcagacgt ccctcggcag cccacaatgg gcagaaggtg acagccatgg caacgaggat   3120

cacagcccgg gtggaaggtg gttaccacag caaccgcagt gtcttctgca ccatcctgtg   3180

a                                                                   3181


<210>  906
<211>  962
<212>  PRT
<213>  Homosapiens

<400>  906

Met Glu Ala Gly Gly Leu Pro Leu Glu Leu Trp Arg Met Ile Leu Ala 
1               5                   10                  15      


Tyr Leu His Leu Pro Asp Leu Gly Arg Cys Ser Leu Val Cys Arg Ala 
            20                  25                  30          


Trp Tyr Glu Leu Ile Leu Ser Leu Asp Ser Thr Arg Trp Arg Gln Leu 
        35                  40                  45              


Cys Leu Gly Cys Thr Glu Cys Arg His Pro Asn Trp Pro Asn Gln Pro 
    50                  55                  60                  


Asp Val Glu Pro Glu Ser Trp Arg Glu Ala Phe Lys Gln His Tyr Leu 
65                  70                  75                  80  


Ala Ser Lys Thr Trp Thr Lys Asn Ala Leu Asp Leu Glu Ser Ser Ile 
                85                  90                  95      


Cys Phe Ser Leu Phe Arg Arg Arg Arg Glu Arg Arg Thr Leu Ser Val 
            100                 105                 110         


Gly Pro Gly Arg Glu Phe Asp Ser Leu Gly Ser Ala Leu Ala Met Ala 
        115                 120                 125             


Ser Leu Tyr Asp Arg Ile Val Leu Phe Pro Gly Val Tyr Glu Glu Gln 
    130                 135                 140                 


Gly Glu Ile Ile Leu Lys Val Pro Val Glu Ile Val Gly Gln Gly Lys 
145                 150                 155                 160 


Leu Gly Glu Val Ala Leu Leu Ala Ser Ile Asp Gln His Cys Ser Thr 
                165                 170                 175     


Thr Arg Leu Cys Asn Leu Val Phe Thr Pro Ala Trp Phe Ser Pro Ile 
            180                 185                 190         


Met Tyr Lys Thr Thr Ser Gly His Val Gln Phe Asp Asn Cys Asn Phe 
        195                 200                 205             


Glu Asn Gly His Ile Gln Val His Gly Pro Gly Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Cys Thr Phe Lys Asn Thr His Ile Phe Leu His Asn Val Pro Leu 
225                 230                 235                 240 


Cys Val Leu Glu Asn Cys Glu Phe Val Gly Ser Glu Asn Asn Ser Val 
                245                 250                 255     


Thr Val Glu Gly His Pro Ser Ala Asp Lys Asn Trp Ala Tyr Lys Tyr 
            260                 265                 270         


Leu Leu Gly Leu Ile Lys Ser Ser Pro Thr Phe Leu Pro Thr Glu Asp 
        275                 280                 285             


Ser Asp Phe Leu Met Ser Leu Asp Leu Glu Ser Arg Asp Gln Ala Trp 
    290                 295                 300                 


Ser Pro Lys Thr Cys Asp Ile Val Ile Glu Gly Ser Gln Ser Pro Thr 
305                 310                 315                 320 


Ser Pro Ala Ser Ser Ser Pro Lys Pro Gly Ser Lys Ala Gly Ser Gln 
                325                 330                 335     


Glu Ala Glu Val Gly Ser Asp Gly Glu Arg Val Ala Gln Thr Pro Asp 
            340                 345                 350         


Ser Ser Asp Gly Gly Leu Ser Pro Ser Gly Glu Asp Glu Asp Glu Asp 
        355                 360                 365             


Gln Leu Met Tyr Arg Leu Ser Tyr Gln Val Gln Gly Pro Arg Pro Val 
    370                 375                 380                 


Leu Gly Gly Ser Phe Leu Gly Pro Pro Leu Pro Gly Ala Ser Ile Gln 
385                 390                 395                 400 


Leu Pro Ser Cys Leu Val Leu Asn Ser Leu Gln Gln Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Glu Ala Met Ala Leu Ala Asn Ser Val Gln Gly Cys Leu Ile 
            420                 425                 430         


Arg Lys Cys Leu Phe Arg Asp Gly Lys Gly Gly Val Phe Val Cys Ser 
        435                 440                 445             


His Gly Arg Ala Lys Met Glu Gly Asn Ile Phe Arg Asn Leu Thr Tyr 
    450                 455                 460                 


Ala Val Arg Cys Ile His Asn Ser Lys Ile Ile Met Leu Arg Asn Asp 
465                 470                 475                 480 


Ile Tyr Arg Cys Arg Ala Ser Gly Ile Phe Leu Arg Leu Glu Gly Gly 
                485                 490                 495     


Gly Leu Ile Ala Gly Asn Asn Ile Tyr His Asn Ala Glu Ala Gly Val 
            500                 505                 510         


Asp Ile Arg Lys Lys Ser Asn Pro Leu Ile Leu Cys Asn Gln Ile His 
        515                 520                 525             


His Gly Leu Arg Ser Gly Ile Val Val Leu Gly Asn Gly Lys Gly Ile 
    530                 535                 540                 


Ile Arg Asn Asn Gln Ile Phe Ser Asn Lys Glu Ala Gly Ile Tyr Ile 
545                 550                 555                 560 


Leu Tyr His Gly Asn Pro Val Val Ser Gly Asn His Ile Phe Lys Gly 
                565                 570                 575     


Arg Ala Ala Gly Ile Ala Val Asn Glu Asn Gly Lys Gly Leu Ile Thr 
            580                 585                 590         


Glu Asn Val Ile Arg Glu Asn Gln Trp Gly Gly Val Asp Ile Arg Arg 
        595                 600                 605             


Gly Gly Ile Pro Val Leu Arg Ser Asn Leu Ile Cys Phe Gly Tyr Ser 
    610                 615                 620                 


Asp Gly Val Val Val Gly Asp Glu Gly Lys Gly Leu Ile Glu Gly Asn 
625                 630                 635                 640 


Thr Ile Tyr Ala Asn Lys Gly Cys Gly Val Trp Met Met Ser Ser Ser 
                645                 650                 655     


Leu Pro His Val Thr Ser Asn His Val Ser Tyr Asn Gly Leu Tyr Gly 
            660                 665                 670         


Val Ala Val Phe Ser Gln Lys Asp Gly Ser Ser Glu Leu Pro Arg Gly 
        675                 680                 685             


His Arg Ala Gln Glu Asn Phe Ser Glu Asp Gly Asp Ala Ile Leu Trp 
    690                 695                 700                 


Glu Thr Glu Leu Glu Lys Glu Asp Asp Pro Leu Arg Arg Pro Ile Thr 
705                 710                 715                 720 


Ile Ala Leu Val Glu Ser Asn Ser Ile Asn His Asn Gly Ala Ser Gly 
                725                 730                 735     


Leu Tyr Val Gln Ser Ser Glu Ala Leu His Val Ile Thr Asn Val Ile 
            740                 745                 750         


His Ala Asn Gly Asp Arg Gly Ile Thr Val Ala Gln Ser Ser Gln Pro 
        755                 760                 765             


Thr Arg Val Ala Asn Asn Ser Ile Ser Cys Asn Arg Gln Ser Gly Val 
    770                 775                 780                 


Lys Val Glu Ala Gln Cys Lys Val Glu Leu Arg Gly Asn Gly Ile Tyr 
785                 790                 795                 800 


Asp Asn Arg Gly His Gly Ile Ile Thr Lys Gly Asp Ser Thr Ile Val 
                805                 810                 815     


Ile Glu Asn Asp Ile Ile Gly Asn Arg Gly Ser Gly Leu Gln Leu Leu 
            820                 825                 830         


Pro Arg Ser Asp Thr Lys Val Ser Met Ser Ala Cys Val Ile Lys Asn 
        835                 840                 845             


Arg Ile His Ser Phe Arg Ala Tyr Gly Ile Ala Val Arg Gly Arg Ala 
    850                 855                 860                 


Lys Ala Leu Val Gln Glu Asn Ile Ile Phe Gln Gly Lys Thr Ser Lys 
865                 870                 875                 880 


Thr Ile Phe Gln Gln Ile Ser Asn Asn Arg Glu Cys Ile Met Gln Asn 
                885                 890                 895     


Asn Lys Phe Leu Val Phe Lys Lys Lys Ser Asp Thr Trp Arg Leu Val 
            900                 905                 910         


Asn Pro Pro Ala Arg Pro His Leu Glu Asn Ser Leu Arg Arg Pro Ser 
        915                 920                 925             


Ala Ala His Asn Gly Gln Lys Val Thr Ala Met Ala Thr Arg Ile Thr 
    930                 935                 940                 


Ala Arg Val Glu Gly Gly Tyr His Ser Asn Arg Ser Val Phe Cys Thr 
945                 950                 955                 960 


Ile Leu 
        


<210>  907
<211>  1013
<212>  DNA
<213>  Homosapiens

<400>  907
gcggccacca tcttggaacg ggaggcggag cagagccgac tgggagcgac tgagcgggct     60

tccgccgccg ccatgaaccc cggatatgac tgcctgttta agctgctttt gattggcgac    120

tcaggcgtgg gcaagtcatg cctgctcctg cggtttgctg atgaccctta cacagagagc    180

tacatcagca ccatcggggt ggacttcaag atccaaacca tcgagctgga tggcaaaact    240

atcaaacttc agatctggga cacggcgggc caggaacggt tctggaccat cacttccagc    300

tactaccggg gggctcatgg cttcctcgtg gtatatgacg tcactgacca ggaatcctat    360

gccaacgtga agcagtggct gcaggagatt gaccgccatg ccagcgagaa cgtcaataag    420

ctcctggtgg gcaacaagag cgacctcacc accaagaagg tggtggacaa caccacagcc    480

aaggagtttg cagactcttt gggcatcccc ttcttggaga cgagtgccaa gaatgccacc    540

aatgtcgagc aggcgttcat gaccatggct gctgagatca aaaagcagat ggggcccgga    600

gcagcctccg ggggcgagcg gcccaatctc aagatcgaca gcacccctgt aaagccggct    660

ggcggtggtt gttgctagga ggggcactgg agtgggacag gagggggcac cttctccaaa    720

tgatgtccct ggaggggaca ggaggtgcct ccctcttcct ctcctggggc atttgagtct    780

gtggctttgg ggtgtcctgg gctccccatc tccctctggc ccatctgcct gctgccccga    840

gccgctattc tgtcagggtc cctaagggag gacactcagg acctgtggcc aggcagggcg    900

ggggcctgct ctgctgctgc ctctaggtga ctttccaaga tgccccccct acacaccttt    960

ctttggaact agggctcttc tgtcggtctc cctcccaccc ccatgtgtgc tgc          1013


<210>  908
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  908

Met Asn Pro Gly Tyr Asp Cys Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Pro 
            20                  25                  30          


Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Gln 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Trp Thr Ile Thr Ser Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala His Gly Phe Leu Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                85                  90                  95      


Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg His Ala Ser Glu 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
        115                 120                 125             


Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
    130                 135                 140                 


Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
145                 150                 155                 160 


Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Gln Met Gly Pro Gly 
                165                 170                 175     


Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
            180                 185                 190         


Val Lys Pro Ala Gly Gly Gly Cys Cys 
        195                 200     


<210>  909
<211>  2537
<212>  DNA
<213>  Homosapiens

<400>  909
gaggtggagg cgagcgaaca gagggaggga cccgcccgcc gcgccccggc cgctgggcat     60

gtgtgtccgc aggcgcccga cgctgccgat gtcccggggc tgagcagcgc ccaggtgtcc    120

cggacagtgc gtgcgagcgt gtgtgtccgc gcaggcgagc accgcgccgg ccctgagcct    180

cccgctcgct ccccacggcc gcggtgcatg ttcgcctcct gccactgtgt gccgagaggc    240

aggaggacca tgaaatgatc cactttcgga gctccagcgt caaatcgctc agccaggaga    300

tgagatgcac catccggctg ctggacgact cggagatctc ctgccacatc cagagggaaa    360

ccaaagggca gtttctcatt gaccacatct gcaactacta cagcctgctg gagaaggact    420

actttggcat tcgctatgtg gacccagaga agcaaaggca ctggcttgaa cctaacaagt    480

ccatcttcaa gcaaatgaaa actcatccac catacaccat gtgctttaga gtgaaattct    540

acccacatga acccttgaag attaaagaag agctcacaag atacctttta taccttcaga    600

ttaaaaggga catttttcat ggccacctgc tgtgctcctt ttctgatgct gcctacctgg    660

gtgcctgtat tgttcaagct gagcttggtg attacgatcc taatgagcat cctgagaatt    720

acatcagtga gtttgagatt ttccccaagc agtcacagaa gctggaaaga aaaatagtgg    780

aaattcataa aaatgaactc agggggcaga gcccaccagt tgctgaattt aacttgctcc    840

tgaaagctca cactttggaa acctacgggg tggatcctca cccatgcaag gattcaacag    900

gcacaacaac atttttagga ttcacagctg caggctttgt ggtctttcag ggaaataaga    960

gaatccattt gataaaatgg ccagatgtct gcaaattgaa gtttgaaggg aagacatttt   1020

atgtgattgg cacccagaag gagaaaaaag ccatgttggc attcaatact tcaacaccag   1080

ctgcctgcaa acatctttgg aagtgtggag tggaaaacca ggccttttat aagtatgcaa   1140

aatccagtca gatcaagact gtatcaagca gcaagatatt ttttaaagga agtagatttc   1200

gatatagtgg gaaagttgcc aaagaggtgg tggaggccag ttccaagatc cagagggagc   1260

ctcctgaggt gcacagagcc aacattactc agagccgcag ttcccactcc ttgaacaaac   1320

agctcatcat taacatggaa cccctgcagc ccctgcttcc ttcccccagc gagcaagaag   1380

aagaacttcc tctgggtgag ggtgttccat tgcctaaaga ggagaacatt tctgctccct   1440

tgatctccag ctccccagtg aaggcagccc gggagtatga agatccccct agtgaagagg   1500

aagataaaat aaaagaagaa cctttaacca tctctgaact agtgtacaac ccaagtgcca   1560

gcctgctccc cacccctgtg gatgacgatg agattgacat gctctttgac tgtccttcta   1620

ggcttgagtt ggaaagagaa gacacagatt catttgagga tctggaagca gatgaaaacg   1680

cctttttgat tgctgaagaa gaggagctga aggaggctcg ccgtgctttg tcgtggagct   1740

acgacattct gactggccat attcgggtga acccactggt caagagtttt tccaggctcc   1800

ttgtggtggg cctgggactg ctgctctttg tatttcccct gctcctcctc cttttggagt   1860

caggtattga tctctccttc ttatgcgaaa tccgccagac accagagttt gagcagtttc   1920

actatgaata ctactgtccc ctcaaggagt gggtggctgg gaaagtccac ctcatcctct   1980

acatgctggg ttgctcatga agttaatctc tcacgtgact aagggctata ttcaatgcta   2040

gtgatttctt tttttcagca aatgcctggt tctgaagggt cacggggctg tcaacaggtg   2100

ttccttactc ataattgatt attcaaacct ttaagttagc tttccataat tcactgcact   2160

taaataagtt taaatcaaat acagttattt tagttacagg ttaggaagat ggtctttaaa   2220

taaccaaaaa tatgtttatt ttttattata gtgtagacat acccttcatc tattatatca   2280

taatacatgt tacattggac tgaattagat tttcccattt ctaatagttg gcaccattat   2340

aagctataag gttcagaatc agaattttag taacaactca agagaaagtt gttgaatata   2400

atccttagtg aagacagtgt cctctaacca atgcctatac aactaaattt atgctgggtt   2460

tttggttttg tttttttaaa aatattttta tgtgttcaaa ctattttggt aaatttttag   2520

caaaaaaaaa aaaaaaa                                                  2537


<210>  910
<211>  581
<212>  PRT
<213>  Homosapiens

<400>  910

Met Ile His Phe Arg Ser Ser Ser Val Lys Ser Leu Ser Gln Glu Met 
1               5                   10                  15      


Arg Cys Thr Ile Arg Leu Leu Asp Asp Ser Glu Ile Ser Cys His Ile 
            20                  25                  30          


Gln Arg Glu Thr Lys Gly Gln Phe Leu Ile Asp His Ile Cys Asn Tyr 
        35                  40                  45              


Tyr Ser Leu Leu Glu Lys Asp Tyr Phe Gly Ile Arg Tyr Val Asp Pro 
    50                  55                  60                  


Glu Lys Gln Arg His Trp Leu Glu Pro Asn Lys Ser Ile Phe Lys Gln 
65                  70                  75                  80  


Met Lys Thr His Pro Pro Tyr Thr Met Cys Phe Arg Val Lys Phe Tyr 
                85                  90                  95      


Pro His Glu Pro Leu Lys Ile Lys Glu Glu Leu Thr Arg Tyr Leu Leu 
            100                 105                 110         


Tyr Leu Gln Ile Lys Arg Asp Ile Phe His Gly His Leu Leu Cys Ser 
        115                 120                 125             


Phe Ser Asp Ala Ala Tyr Leu Gly Ala Cys Ile Val Gln Ala Glu Leu 
    130                 135                 140                 


Gly Asp Tyr Asp Pro Asn Glu His Pro Glu Asn Tyr Ile Ser Glu Phe 
145                 150                 155                 160 


Glu Ile Phe Pro Lys Gln Ser Gln Lys Leu Glu Arg Lys Ile Val Glu 
                165                 170                 175     


Ile His Lys Asn Glu Leu Arg Gly Gln Ser Pro Pro Val Ala Glu Phe 
            180                 185                 190         


Asn Leu Leu Leu Lys Ala His Thr Leu Glu Thr Tyr Gly Val Asp Pro 
        195                 200                 205             


His Pro Cys Lys Asp Ser Thr Gly Thr Thr Thr Phe Leu Gly Phe Thr 
    210                 215                 220                 


Ala Ala Gly Phe Val Val Phe Gln Gly Asn Lys Arg Ile His Leu Ile 
225                 230                 235                 240 


Lys Trp Pro Asp Val Cys Lys Leu Lys Phe Glu Gly Lys Thr Phe Tyr 
                245                 250                 255     


Val Ile Gly Thr Gln Lys Glu Lys Lys Ala Met Leu Ala Phe Asn Thr 
            260                 265                 270         


Ser Thr Pro Ala Ala Cys Lys His Leu Trp Lys Cys Gly Val Glu Asn 
        275                 280                 285             


Gln Ala Phe Tyr Lys Tyr Ala Lys Ser Ser Gln Ile Lys Thr Val Ser 
    290                 295                 300                 


Ser Ser Lys Ile Phe Phe Lys Gly Ser Arg Phe Arg Tyr Ser Gly Lys 
305                 310                 315                 320 


Val Ala Lys Glu Val Val Glu Ala Ser Ser Lys Ile Gln Arg Glu Pro 
                325                 330                 335     


Pro Glu Val His Arg Ala Asn Ile Thr Gln Ser Arg Ser Ser His Ser 
            340                 345                 350         


Leu Asn Lys Gln Leu Ile Ile Asn Met Glu Pro Leu Gln Pro Leu Leu 
        355                 360                 365             


Pro Ser Pro Ser Glu Gln Glu Glu Glu Leu Pro Leu Gly Glu Gly Val 
    370                 375                 380                 


Pro Leu Pro Lys Glu Glu Asn Ile Ser Ala Pro Leu Ile Ser Ser Ser 
385                 390                 395                 400 


Pro Val Lys Ala Ala Arg Glu Tyr Glu Asp Pro Pro Ser Glu Glu Glu 
                405                 410                 415     


Asp Lys Ile Lys Glu Glu Pro Leu Thr Ile Ser Glu Leu Val Tyr Asn 
            420                 425                 430         


Pro Ser Ala Ser Leu Leu Pro Thr Pro Val Asp Asp Asp Glu Ile Asp 
        435                 440                 445             


Met Leu Phe Asp Cys Pro Ser Arg Leu Glu Leu Glu Arg Glu Asp Thr 
    450                 455                 460                 


Asp Ser Phe Glu Asp Leu Glu Ala Asp Glu Asn Ala Phe Leu Ile Ala 
465                 470                 475                 480 


Glu Glu Glu Glu Leu Lys Glu Ala Arg Arg Ala Leu Ser Trp Ser Tyr 
                485                 490                 495     


Asp Ile Leu Thr Gly His Ile Arg Val Asn Pro Leu Val Lys Ser Phe 
            500                 505                 510         


Ser Arg Leu Leu Val Val Gly Leu Gly Leu Leu Leu Phe Val Phe Pro 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Glu Ser Gly Ile Asp Leu Ser Phe Leu Cys 
    530                 535                 540                 


Glu Ile Arg Gln Thr Pro Glu Phe Glu Gln Phe His Tyr Glu Tyr Tyr 
545                 550                 555                 560 


Cys Pro Leu Lys Glu Trp Val Ala Gly Lys Val His Leu Ile Leu Tyr 
                565                 570                 575     


Met Leu Gly Cys Ser 
            580     


<210>  911
<211>  1630
<212>  DNA
<213>  Homosapiens

<400>  911
gcgcagaggg gcacggccct cactgccccg gccggggcga gagcggctcc gcccctcgag     60

cgccgggtag gccggggccg gcggggcccg gaaggcgacg ggaaggagcc gagcttgggt    120

tatggcggcg ccgggcgcgc tgctggtgat gggcactctc gctctgtcgc ccaggctgga    180

gtacagtggc gtgatctcgg ctcgctgcaa cctctgcctc ctgagttcgg gcgattgtca    240

tgcctcggcc tccggagtag ctggggttac aggcgtgcac cacaacaccc ggctgggttt    300

tgtattttta gttgagacgg ggttttgccg tgttggcaga gctggtcccg aactcctggc    360

ctcaggtgat ccgcctgcct cagcctccca aagtgctggg attataggcg tgagccaagg    420

gctcaaccta acttggtctt aagtgtgatt tctgctatgc acacttctgg cttcaccagc    480

catggagttt ggccgggatg gtctactcat ccgtaggctg catgtctccc tgcgcagcct    540

tcaatagaat gaactaatgg gaaaggtttc actgctctcg caacctttgg ttacatccag    600

gagcagatct cagtttggta caactgtgtc taacacctct ctgatagctt tttagtgaaa    660

gaaagaggac ctttgttagg caacagtatc cagctagaat ttaatcacat tgttctgttt    720

tcattatata cagcttttca ggtaccttct attcaagatc caccgtgggc gccctgctgg    780

catctgagct gggatggaaa ttctatgatg ctgatgatta tcacccggag gaaaatcgaa    840

ggaagatggg aaaaggcata ccgctcaatg accaggaccg gattccatgg ctctgtaact    900

tgcatgacat tttactaaga gatgtagcct ctggacagcg tgtggttcta gcctgttcag    960

ccctgaagaa aacgtacaga gacatattaa cacaaggaaa agatggtgta gctctgaagt   1020

gtgaggagtc gggaaaggaa gcaaagcagg ctgagatgca gctcctggtg gtccatctga   1080

gcgggtcgtt tgaggtcatc tctggacgct tactcaaaag agagggacat tttatgcccc   1140

ctgaattatt gcagtcccag tttgagactc tggagccccc agcagctcca gaaaacttta   1200

tccaaataag tgtggacaaa aatgtttcag agataattgc tacaattatg gaaaccctaa   1260

aaatgaaatg acaatgattt tgtatcagtg gtccaaacag aactaagcat aaatcattgt   1320

gccatcacaa acctcgttcc agccgccttg cccatactag attctaaatg tttctaaagg   1380

caaaccccaa tgtgtcaaga cagacttgtt taggtgtaat tttaggaatt atgctggttc   1440

atcaggaagc agagggggag ttttaaaagt caagcttaaa ttgaagttta aattcatcta   1500

taaccaaatc aaatgatcag aggaaattct gtaatcaatg ctggaaatcg ttacattgtt   1560

tagaacattc ttgctcatgc ctgtatttgc acaaataaat gaaacttcgc tgtcaaaaaa   1620

aaaaaaaaaa                                                          1630


<210>  912
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  912

Met Gly Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu 
1               5                   10                  15      


Cys Asn Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg 
            20                  25                  30          


Val Val Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu 
        35                  40                  45              


Thr Gln Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys 
    50                  55                  60                  


Glu Ala Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly 
65                  70                  75                  80  


Ser Phe Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe 
                85                  90                  95      


Met Pro Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro 
            100                 105                 110         


Ala Ala Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser 
        115                 120                 125             


Glu Ile Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys 
    130                 135                 140     


<210>  913
<211>  3952
<212>  DNA
<213>  Homosapiens

<400>  913
gggatgactc ggcgacgccg ccaggcgcgt tacccggcgt gctccgcgcg gcgccagcga     60

agggacgtgg gggaaggggc agggaggagg aagcggtggc tgctgcggat gtcggtgtga    120

gcgagcggcg cctgaacaca cggcggctgc cgagcgcctg acccgggcct gcgccagagc    180

ctgcaccgag ctccggggcc ccacacccgc tacggtggcc ctgcgcccgt tgctactgag    240

gcggcgtgct ctgcattctt cgctgtccag gcctgccggc tctggtgtct gctggctcct    300

ccttgctcgc ctgctccctc ctgcttgcct gagtcaccgc cgccgccgcc gccacagcca    360

tggccgagag tggtgaaagc ggcggtcctc cgggctccca ggatagcgcc gccggagccg    420

aaggtgctgg cgcccccgcg gccgctgcct ccgcggagcc caaaatcatg aaagtcaccg    480

tgaagacccc gaaggaaaag gaggaattcg ccgtgcccga gaatagctcc gtccagcagt    540

ttaaggaaga aatctctaaa cgttttaaat cacatactga ccaacttgtg ttgatatttg    600

ctggaaaaat tttgaaagat caagatacct tgagtcagca tggaattcat gatggactta    660

ctgttcacct tgtcattaaa acacaaaaca ggcctcagga tcattcagct cagcaaacaa    720

atacagctgg aagcaatgtt actacatcat caactcctaa tagtaactct acatctggtt    780

ctgctactag caaccctttt ggtttaggtg gccttggggg acttgcaggt ctgagtagct    840

tgggtttgaa tactaccaac ttctctgaac tacagagtca gatgcagcga caacttttgt    900

ctaaccctga aatgatggtc cagatcatgg aaaatccctt tgttcagagc atgctctcaa    960

atcctgacct gatgagacag ttaattatgg ccaatccaca aatgcagcag ttgatacaga   1020

gaaatccaga aattagtcat atgttgaata atccagatat aatgagacaa acgttggaac   1080

ttgccaggaa tccagcaatg atgcaggaga tgatgaggaa ccaggaccga gctttgagca   1140

acctagaaag catcccaggg ggatataatg ctttaaggcg catgtacaca gatattcagg   1200

aaccaatgct gagtgctgca caagagcagt ttggtggtaa tccatttgct tccttggtga   1260

gcaatacatc ctctggtgaa ggtagtcaac cttcccgtac agaaaataga gatccactac   1320

ccaatccatg ggctccacag acttcccaga gttcatcagc ttccagcggc actgccagca   1380

ctgtgggtgg cactactggt agtactgcca gtggcacttc tgggcagagt actactgcgc   1440

caaatttggt gcctggagta ggagctagta tgttcaacac accaggaatg cagagcttgt   1500

tgcaacaaat aactgaaaac ccacaactga tgcaaaacat gttgtctgcc ccctacatga   1560

gaagcatgat gcagtcacta agccagaatc ctgaccttgc tgcacagatg atgctgaata   1620

atcccctatt tgctggaaat cctcagcttc aagaacaaat gagacaacag ctcccaactt   1680

tcctccaaca aatgcagaat cctgatacac tatcagcaat gtcaaaccct agagcaatgc   1740

aggccttgtt acagattcag cagggtttac agacattagc aacggaagcc ccgggcctca   1800

tcccagggtt tactcctggc ttgggggcat taggaagcac tggaggctct tcgggaacta   1860

atggatctaa cgccacacct agtgaaaaca caagtcccac agcaggaacc actgaacctg   1920

gacatcagca gtttattcag cagatgctgc aggctcttgc tggagtaaat cctcagctac   1980

agaatccaga agtcagattt cagcaacaac tggaacaact cagtgcaatg ggatttttga   2040

accgtgaagc aaacttgcaa gctctaatag caacaggagg tgatatcaat gcagctattg   2100

aaaggttact gggctcccag ccatcatagc agcatttctg tatcttgaaa aaatgtaatt   2160

tatttttgat aacggctctt aaactttaaa atacctgctt tatttcattt tgactcttgg   2220

aattctgtgc tgttataaac aaacccaata tgatgcattt taaggtggag tacagtaaga   2280

tgtgtgggtt tttctgtatt tttcttttct ggaacagtgg gaattaaggc tactgcatgc   2340

atcacttctg catttattgt aattttttaa aaacatcacc ttttatagtt gggtgaccag   2400

attttgtcct gcatctgtcc agtttatttg ctttttaaac attagcctat ggtagtaatt   2460

tatgtagaat aaaagcatta aaaagaagca aatcatttgc actctataat ttgtggtaca   2520

gtattgctta ttgtgacttt ggcatgcatt tttgcaaaca atgctgtaag atttatacta   2580

ctgataattt tgttttattt gtatacaata tagagtatgc acatttggga ctgcatttct   2640

ggaaacatac tgcaataggc tctctgagca aaacacctgt aactaaaaaa gtgaagataa   2700

gaaaatactc ttaaagctga gtatttccta attgtataga atcttacagc atctttgaca   2760

aacatctccc agcaaaagtg ccggttagtc aggtttgttg aaaatacagt agaaaagctg   2820

attctggtta tctctttaag gacaattaat tgtacagaca cataatgtaa cattgtctca   2880

acattcattc acagattgac tgtaaattac cttaatcttt gtgcagactg aaggaacact   2940

gtagtatacc ccaaagtgca tttgcctagg acttctcagc ttctcccata ggtagtttaa   3000

caggcattaa aatttgtaat tgaaatgttg ctttcactga aaaagtgtct tgatgtttca   3060

gttattttta atcgccataa aaaaatagaa ctatcttttg ggtttatctg ttttctcatg   3120

cacaggcaat acacaaattt aaaatgagtt gtgagccaat tgtttctgaa gtgttttggt   3180

agttctatta agaaatagtt aaatattgtg cttttcagag cctcagagaa agggggacgg   3240

ggtggggggg tggggcagcg gaatctgtcc tggatggggc cagcttaaat aatactggca   3300

accaagattc tgttaggatt tctgtgcata tagtgtagta aagaagtatc attcaggggt   3360

gaaaaacaaa gagccgtttt aatgatgttg agtacatttg gctgttttat agcctttttc   3420

ttccctcccc caaagaattc tgtttgccta actcccaaac tgttggggtg gtacattcct   3480

ttaggaccaa ttaaaacata attgagggtc agtgatacat ttggctgact ctggttcagt   3540

attctcttag gtgattatat tctctcatgt acagttacag gaaattaaaa tgttaaagta   3600

acctaaaatg aattcagacc aataaaatca agggaaatac aagttgattg cattacttct   3660

gtatgttgct tgctattaaa aaggttaaga ggccaggtta cccaccagtc cttgcactgt   3720

tctgacactt tccccaggag gaaaacaagt acaaaggtta cggtggaggc ataagtagaa   3780

gagattgtta agaagggtat tcatgtgtct ttgctctttc tgctttatgc ctcagtttgg   3840

tttaaaaact tctgtactgg caaatggtgg tattcagtgt gggatagtgt cataactaat   3900

ttgacaattt attaatcata aaataacaat aaatctctag cttttacact tg           3952


<210>  914
<211>  589
<212>  PRT
<213>  Homosapiens

<400>  914

Met Ala Glu Ser Gly Glu Ser Gly Gly Pro Pro Gly Ser Gln Asp Ser 
1               5                   10                  15      


Ala Ala Gly Ala Glu Gly Ala Gly Ala Pro Ala Ala Ala Ala Ser Ala 
            20                  25                  30          


Glu Pro Lys Ile Met Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu 
        35                  40                  45              


Glu Phe Ala Val Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Glu 
    50                  55                  60                  


Ile Ser Lys Arg Phe Lys Ser His Thr Asp Gln Leu Val Leu Ile Phe 
65                  70                  75                  80  


Ala Gly Lys Ile Leu Lys Asp Gln Asp Thr Leu Ser Gln His Gly Ile 
                85                  90                  95      


His Asp Gly Leu Thr Val His Leu Val Ile Lys Thr Gln Asn Arg Pro 
            100                 105                 110         


Gln Asp His Ser Ala Gln Gln Thr Asn Thr Ala Gly Ser Asn Val Thr 
        115                 120                 125             


Thr Ser Ser Thr Pro Asn Ser Asn Ser Thr Ser Gly Ser Ala Thr Ser 
    130                 135                 140                 


Asn Pro Phe Gly Leu Gly Gly Leu Gly Gly Leu Ala Gly Leu Ser Ser 
145                 150                 155                 160 


Leu Gly Leu Asn Thr Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln 
                165                 170                 175     


Arg Gln Leu Leu Ser Asn Pro Glu Met Met Val Gln Ile Met Glu Asn 
            180                 185                 190         


Pro Phe Val Gln Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu 
        195                 200                 205             


Ile Met Ala Asn Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu 
    210                 215                 220                 


Ile Ser His Met Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu 
225                 230                 235                 240 


Leu Ala Arg Asn Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp 
                245                 250                 255     


Arg Ala Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu 
            260                 265                 270         


Arg Arg Met Tyr Thr Asp Ile Gln Glu Pro Met Leu Ser Ala Ala Gln 
        275                 280                 285             


Glu Gln Phe Gly Gly Asn Pro Phe Ala Ser Leu Val Ser Asn Thr Ser 
    290                 295                 300                 


Ser Gly Glu Gly Ser Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu 
305                 310                 315                 320 


Pro Asn Pro Trp Ala Pro Gln Thr Ser Gln Ser Ser Ser Ala Ser Ser 
                325                 330                 335     


Gly Thr Ala Ser Thr Val Gly Gly Thr Thr Gly Ser Thr Ala Ser Gly 
            340                 345                 350         


Thr Ser Gly Gln Ser Thr Thr Ala Pro Asn Leu Val Pro Gly Val Gly 
        355                 360                 365             


Ala Ser Met Phe Asn Thr Pro Gly Met Gln Ser Leu Leu Gln Gln Ile 
    370                 375                 380                 


Thr Glu Asn Pro Gln Leu Met Gln Asn Met Leu Ser Ala Pro Tyr Met 
385                 390                 395                 400 


Arg Ser Met Met Gln Ser Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln 
                405                 410                 415     


Met Met Leu Asn Asn Pro Leu Phe Ala Gly Asn Pro Gln Leu Gln Glu 
            420                 425                 430         


Gln Met Arg Gln Gln Leu Pro Thr Phe Leu Gln Gln Met Gln Asn Pro 
        435                 440                 445             


Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Ala Leu Leu 
    450                 455                 460                 


Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr Glu Ala Pro Gly Leu 
465                 470                 475                 480 


Ile Pro Gly Phe Thr Pro Gly Leu Gly Ala Leu Gly Ser Thr Gly Gly 
                485                 490                 495     


Ser Ser Gly Thr Asn Gly Ser Asn Ala Thr Pro Ser Glu Asn Thr Ser 
            500                 505                 510         


Pro Thr Ala Gly Thr Thr Glu Pro Gly His Gln Gln Phe Ile Gln Gln 
        515                 520                 525             


Met Leu Gln Ala Leu Ala Gly Val Asn Pro Gln Leu Gln Asn Pro Glu 
    530                 535                 540                 


Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Ser Ala Met Gly Phe Leu 
545                 550                 555                 560 


Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr Gly Gly Asp Ile 
                565                 570                 575     


Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro Ser 
            580                 585                 


<210>  915
<211>  2354
<212>  DNA
<213>  Homosapiens

<400>  915
ggaggaagcg gtggctgctg cggatgtcgg tgtgagcgag cggcgcctga acacacggcg     60

gctgccgagc gcctgacccg ggcctgcgcc agagcctgca ccgagctccg gggccccaca    120

cccgctacgg tggccctgcg cccgttgcta ctgaggcggc gtgctctgca ttcttcgctg    180

tccaggcctg ccggctctgg tgtctgctgg ctcctccttg ctcgcctgct ccctcctgct    240

tgcctgagtc accgccgccg ccgccgccac agccatggcc gagagtggtg aaagcggcgg    300

tcctccgggc tcccaggata gcgccgccgg agccgaaggt gctggcgccc ccgcggccgc    360

tgcctccgcg gagcccaaaa tcatgaaagt caccgtgaag accccgaagg aaaaggagga    420

attcgccgtg cccgagaata gctccgtcca gcagtttaag gaagaaatct ctaaacgttt    480

taaatcacat actgaccaac ttgtgttgat atttgctgga aaaattttga aagatcaaga    540

taccttgagt cagcatggaa ttcatgatgg acttactgtt caccttgtca ttaaaacaca    600

aaacaggcct caggatcatt cagctcagca aacaaataca gctggaagca atgttactac    660

atcatcaact cctaatagta actctacatc tggttctgct actagcaacc cttttggttt    720

aggtggcctt gggggacttg caggtctgag tagcttgggt ttgaatacta ccaacttctc    780

tgaactacag agtcagatgc agcgacaact tttgtctaac cctgaaatga tggtccagat    840

catggaaaat ccctttgttc agagcatgct ctcaaatcct gacctgatga gacagttaat    900

tatggccaat ccacaaatgc agcagttgat acagagaaat ccagaaatta gtcatatgtt    960

gaataatcca gatataatga gacaaacgtt ggaacttgcc aggaatccag caatgatgca   1020

ggagatgatg aggaaccagg accgagcttt gagcaaccta gaaagcatcc cagggggata   1080

taatgcttta aggcgcatgt acacagatat tcaggaacca atgctgagtg ctgcacaaga   1140

gcagtttggt ggtaatccat ttgcttcctt ggtgagcaat acatcctctg gtgaaggtag   1200

tcaaccttcc cgtacagaaa atagagatcc actacccaat ccatgggctc cacagacttc   1260

ccagagttca tcagcttcca gcggcactgc cagcactgtg ggtggcacta ctggtagtac   1320

tgccagtggc acttctgggc agagtactac tgcgccaaat ttggtgcctg gagtaggagc   1380

tagtatgttc aacacaccag gaatgcagag cttgttgcaa caaataactg aaaacccaca   1440

actgatgcaa aacatgttgt ctgcccccta catgagaagc atgatgcagt cactaagcca   1500

gaatcctgac cttgctgcac agatgcagaa tcctgataca ctatcagcaa tgtcaaaccc   1560

tagagcaatg caggccttgt tacagattca gcagggttta cagacattag caacggaagc   1620

cccgggcctc atcccagggt ttactcctgg cttgggggca ttaggaagca ctggaggctc   1680

ttcgggaact aatggatcta acgccacacc tagtgaaaac acaagtccca cagcaggaac   1740

cactgaacct ggacatcagc agtttattca gcagatgctg caggctcttg ctggagtaaa   1800

tcctcagcta cagaatccag aagtcagatt tcagcaacaa ctggaacaac tcagtgcaat   1860

gggatttttg aaccgtgaag caaacttgca agctctaata gcaacaggag gtgatatcaa   1920

tgcagctatt gaaaggttac tgggctccca gccatcatag cagcatttct gtatcttgaa   1980

aaaatgtaat ttatttttga taacggctct taaactttaa aatacctgct ttatttcatt   2040

ttgactcttg gaattctgtg ctgttataaa caaacccaat atgatgcatt ttaaggtgga   2100

gtacagtaag atgtgtgggt ttttctgtat ttttcttttc tggaacagtg ggaattaagg   2160

ctactgcatg catcacttct gcatttattg taatttttta aaaacatcac cttttatagt   2220

tgggtgacca gattttgtcc tgcatctgtc cagtttattt gctttttaaa cattagccta   2280

tggtagtaat ttatgtagaa taaaagcatt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa aaaa                                                     2354


<210>  916
<211>  561
<212>  PRT
<213>  Homosapiens

<400>  916

Met Ala Glu Ser Gly Glu Ser Gly Gly Pro Pro Gly Ser Gln Asp Ser 
1               5                   10                  15      


Ala Ala Gly Ala Glu Gly Ala Gly Ala Pro Ala Ala Ala Ala Ser Ala 
            20                  25                  30          


Glu Pro Lys Ile Met Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu 
        35                  40                  45              


Glu Phe Ala Val Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Glu 
    50                  55                  60                  


Ile Ser Lys Arg Phe Lys Ser His Thr Asp Gln Leu Val Leu Ile Phe 
65                  70                  75                  80  


Ala Gly Lys Ile Leu Lys Asp Gln Asp Thr Leu Ser Gln His Gly Ile 
                85                  90                  95      


His Asp Gly Leu Thr Val His Leu Val Ile Lys Thr Gln Asn Arg Pro 
            100                 105                 110         


Gln Asp His Ser Ala Gln Gln Thr Asn Thr Ala Gly Ser Asn Val Thr 
        115                 120                 125             


Thr Ser Ser Thr Pro Asn Ser Asn Ser Thr Ser Gly Ser Ala Thr Ser 
    130                 135                 140                 


Asn Pro Phe Gly Leu Gly Gly Leu Gly Gly Leu Ala Gly Leu Ser Ser 
145                 150                 155                 160 


Leu Gly Leu Asn Thr Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln 
                165                 170                 175     


Arg Gln Leu Leu Ser Asn Pro Glu Met Met Val Gln Ile Met Glu Asn 
            180                 185                 190         


Pro Phe Val Gln Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu 
        195                 200                 205             


Ile Met Ala Asn Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu 
    210                 215                 220                 


Ile Ser His Met Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu 
225                 230                 235                 240 


Leu Ala Arg Asn Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp 
                245                 250                 255     


Arg Ala Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu 
            260                 265                 270         


Arg Arg Met Tyr Thr Asp Ile Gln Glu Pro Met Leu Ser Ala Ala Gln 
        275                 280                 285             


Glu Gln Phe Gly Gly Asn Pro Phe Ala Ser Leu Val Ser Asn Thr Ser 
    290                 295                 300                 


Ser Gly Glu Gly Ser Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu 
305                 310                 315                 320 


Pro Asn Pro Trp Ala Pro Gln Thr Ser Gln Ser Ser Ser Ala Ser Ser 
                325                 330                 335     


Gly Thr Ala Ser Thr Val Gly Gly Thr Thr Gly Ser Thr Ala Ser Gly 
            340                 345                 350         


Thr Ser Gly Gln Ser Thr Thr Ala Pro Asn Leu Val Pro Gly Val Gly 
        355                 360                 365             


Ala Ser Met Phe Asn Thr Pro Gly Met Gln Ser Leu Leu Gln Gln Ile 
    370                 375                 380                 


Thr Glu Asn Pro Gln Leu Met Gln Asn Met Leu Ser Ala Pro Tyr Met 
385                 390                 395                 400 


Arg Ser Met Met Gln Ser Leu Ser Gln Asn Pro Asp Leu Ala Ala Gln 
                405                 410                 415     


Met Gln Asn Pro Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met 
            420                 425                 430         


Gln Ala Leu Leu Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr Glu 
        435                 440                 445             


Ala Pro Gly Leu Ile Pro Gly Phe Thr Pro Gly Leu Gly Ala Leu Gly 
    450                 455                 460                 


Ser Thr Gly Gly Ser Ser Gly Thr Asn Gly Ser Asn Ala Thr Pro Ser 
465                 470                 475                 480 


Glu Asn Thr Ser Pro Thr Ala Gly Thr Thr Glu Pro Gly His Gln Gln 
                485                 490                 495     


Phe Ile Gln Gln Met Leu Gln Ala Leu Ala Gly Val Asn Pro Gln Leu 
            500                 505                 510         


Gln Asn Pro Glu Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Ser Ala 
        515                 520                 525             


Met Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr 
    530                 535                 540                 


Gly Gly Asp Ile Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro 
545                 550                 555                 560 


Ser 
    


<210>  917
<211>  1796
<212>  DNA
<213>  Homosapiens

<400>  917
tgcagccgcg ctcacctccg cggtccgccc cggcgccccg ggacccgtta gtgcccagcc     60

tgcgggccga ccgcgaccac cgcccggcgc gagcctgccc ccagctctgc cgacacttga    120

cccagaccag tcccaacgcc cagtgcggcc gcccggggag ccgcgggaga ggcggcggcg    180

gggggaggag ggagaggagg gccgagccgg cggcacggga ggcccggttt tgaagccgct    240

tctctgcccg agttaggttt cgcccagcgc aatttctttc tctatgtact ttgcgaataa    300

gtttcggagc atcggttaac agcctatggg tgaaatttgg ctttcattca tgaatgagaa    360

attattcttg acagaagtat tttaaaagaa aaatctttac gatggcctca gcagtactta    420

gttctgttcc caccaccgct tctcgttttg ccctgttaca agtggatagt ggcagtggct    480

ctgattctga acctggaaaa ggtaaaggtc gaaatactgg aaagtctcaa actttaggaa    540

gcaagtcaac tacaaatgag aaaaaaagag agaaaagaag aaaaaagaag gaacagcaac    600

agagtgaagc aaatgagctc aggaatcttg cttttaagaa aattccccag aaatcctccc    660

atgctgtttg taacgctcaa catgatcttc cattgtcaaa cccagtacag aaggattcac    720

gagaagaaaa ttggcaagag tggagacaaa gagatgagca gctgacatct gaaatgtttg    780

aagcagatct tgagaaggca ttgttactaa gtaaactaga atatgaagag cacaaaaagg    840

agtatgaaga tgctgaaaat acttcaactc agtccaaagt tatgaataaa aaagataaaa    900

gaaagaatca tcagggaaaa gacagacctc tcacagtatc actaaaagat tttcattcgg    960

aagatcacat tagtaaaaag actgaggaat tgagttcttc tcagacttta tcacatgatg   1020

gaggattctt caatagactg gaagatgatg ttcataaaat tcttattaga gaaaaacgaa   1080

gagaacagct tacagaatat aatggaacag ataattgtac agctcatgaa cacaaccagg   1140

aagtggttct gaaagatgga agaattgaaa gactaaagtt agagcttgaa aggaaagatg   1200

ctgaaatcca gaagctgaaa aatgtaatca ctcaatggga ggcaaagtat aaggaagtaa   1260

aggcaagaaa tgcacaatta ttgaaaatgc ttcaggaagg tgaaatgaaa gataaggcag   1320

aaatacttct gcaagttgat gaatcacaaa gtatcaagaa tgagctcact attcaggtga   1380

cttcacttca tgctgcatta gaacaagaaa gatctaaagt gaaagtatta caagcagagt   1440

tagccaaata ccagggtggc agaaaaggga aaagaaactc tgaatccgac cagtgtaggt   1500

gattacatta gcctttgaag tcaacacaaa gtttaaaact tccaggattt tgcaaagttg   1560

tatatattta atgctgtgca actgctaaac tatgcagttt ttcttgaagg aactaaaagc   1620

aactagctcc ctaatggtct ataattttat ttcttttggc ttaaagtgaa aaagaagaaa   1680

tagagaattc cagcagaatt cagtggttgt ctactatcca tacttcttat cactttagtt   1740

tttcatcagt caataaaatt aatttactct tccactaaaa aaaaaaaaaa aaaaaa       1796


<210>  918
<211>  366
<212>  PRT
<213>  Homosapiens

<400>  918

Met Ala Ser Ala Val Leu Ser Ser Val Pro Thr Thr Ala Ser Arg Phe 
1               5                   10                  15      


Ala Leu Leu Gln Val Asp Ser Gly Ser Gly Ser Asp Ser Glu Pro Gly 
            20                  25                  30          


Lys Gly Lys Gly Arg Asn Thr Gly Lys Ser Gln Thr Leu Gly Ser Lys 
        35                  40                  45              


Ser Thr Thr Asn Glu Lys Lys Arg Glu Lys Arg Arg Lys Lys Lys Glu 
    50                  55                  60                  


Gln Gln Gln Ser Glu Ala Asn Glu Leu Arg Asn Leu Ala Phe Lys Lys 
65                  70                  75                  80  


Ile Pro Gln Lys Ser Ser His Ala Val Cys Asn Ala Gln His Asp Leu 
                85                  90                  95      


Pro Leu Ser Asn Pro Val Gln Lys Asp Ser Arg Glu Glu Asn Trp Gln 
            100                 105                 110         


Glu Trp Arg Gln Arg Asp Glu Gln Leu Thr Ser Glu Met Phe Glu Ala 
        115                 120                 125             


Asp Leu Glu Lys Ala Leu Leu Leu Ser Lys Leu Glu Tyr Glu Glu His 
    130                 135                 140                 


Lys Lys Glu Tyr Glu Asp Ala Glu Asn Thr Ser Thr Gln Ser Lys Val 
145                 150                 155                 160 


Met Asn Lys Lys Asp Lys Arg Lys Asn His Gln Gly Lys Asp Arg Pro 
                165                 170                 175     


Leu Thr Val Ser Leu Lys Asp Phe His Ser Glu Asp His Ile Ser Lys 
            180                 185                 190         


Lys Thr Glu Glu Leu Ser Ser Ser Gln Thr Leu Ser His Asp Gly Gly 
        195                 200                 205             


Phe Phe Asn Arg Leu Glu Asp Asp Val His Lys Ile Leu Ile Arg Glu 
    210                 215                 220                 


Lys Arg Arg Glu Gln Leu Thr Glu Tyr Asn Gly Thr Asp Asn Cys Thr 
225                 230                 235                 240 


Ala His Glu His Asn Gln Glu Val Val Leu Lys Asp Gly Arg Ile Glu 
                245                 250                 255     


Arg Leu Lys Leu Glu Leu Glu Arg Lys Asp Ala Glu Ile Gln Lys Leu 
            260                 265                 270         


Lys Asn Val Ile Thr Gln Trp Glu Ala Lys Tyr Lys Glu Val Lys Ala 
        275                 280                 285             


Arg Asn Ala Gln Leu Leu Lys Met Leu Gln Glu Gly Glu Met Lys Asp 
    290                 295                 300                 


Lys Ala Glu Ile Leu Leu Gln Val Asp Glu Ser Gln Ser Ile Lys Asn 
305                 310                 315                 320 


Glu Leu Thr Ile Gln Val Thr Ser Leu His Ala Ala Leu Glu Gln Glu 
                325                 330                 335     


Arg Ser Lys Val Lys Val Leu Gln Ala Glu Leu Ala Lys Tyr Gln Gly 
            340                 345                 350         


Gly Arg Lys Gly Lys Arg Asn Ser Glu Ser Asp Gln Cys Arg 
        355                 360                 365     


<210>  919
<211>  1109
<212>  DNA
<213>  Homosapiens

<400>  919
cggcgttctg gattcccatc gtaacttcaa ggaaaacttt cacaatgtgc ggagcccttg     60

atgtcctgca aatgaagaag aaggatgtcc ttaagttcct tgcagcagga acccacttag    120

gtggcaccaa tcttgacttc cagatgaaac agtacatcta taaaaggaaa agttatggca    180

cctacatcac aaatctgaag aggacctggg agaagcttct gctggcagct catgccattg    240

ttgccattga ataccctgct gatgtcagtg tcatattctc caggaatact ggccagaggg    300

ccgtgctgaa gtttgctgct gccactggag ccactccaat tgctggccgc ttcactcctg    360

caaccttcac taaccagatc caggcaacct tccgggagcc acggcttctt gtggttaccg    420

accccagggc tgaccaccag cctctcacgg aggcatctta tgttaaccta cctaccatcg    480

ctctgtgtaa cacagattct cctctgcact gtgtggacat tgccatccca tgcaacaaca    540

agggagctcc ctcagtgggt cagatatggt ggatgccagc tcgggaagtt ctgcacatgc    600

gtggcaccat ttcctgtgaa cacccgtggg aggtcatgcc tgatctctac ttctacagag    660

atcctgaaga gattgaaaaa gaagagcagg ctgctgctga aaaggctgtg accaaggagg    720

aatttcaggg tgagtggact gctctagctc ctgagttcac tgctactcag cctgagattg    780

cagactggtt tgaaggaaga agctttggtg tcgagtccag tagtcggagg cttcctgaga    840

agctcacggc ccagccctgt gatccagttt cctcagtctt cgcggtgtgc accactcagg    900

acgacttgcg gcttacgtcc aggacaaagg gggcttgtcc tttcttcaac gtcctactgc    960

gcaaaaacga agcccttctc aggctgcctg ccttccagga aaagctgcgc cccctcagga   1020

acctgtgccc cgcgcgcctg ccgccgccca ttcccggcgc gcacctggca gtcccgggct   1080

cgagccccgc cctgccgcca gccaggtga                                     1109


<210>  920
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  920

Met Cys Gly Ala Leu Asp Val Leu Gln Met Lys Lys Lys Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Lys Gln Tyr Ile Tyr Lys Arg Lys Ser Tyr Gly Thr Tyr Ile 
        35                  40                  45              


Thr Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala His Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Tyr Pro Ala Asp Val Ser Val Ile Phe Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Ala Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Thr Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu His Cys Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala Pro Ser Val Gly Gln Ile Trp Trp 
                165                 170                 175     


Met Pro Ala Arg Glu Val Leu His Met Arg Gly Thr Ile Ser Cys Glu 
            180                 185                 190         


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205             


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220                 


Glu Glu Phe Gln Gly Glu Trp Thr Ala Leu Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240 


Thr Gln Pro Glu Ile Ala Asp Trp Phe Glu Gly Arg Ser Phe Gly Val 
                245                 250                 255     


Glu Ser Ser Ser Arg Arg Leu Pro Glu Lys Leu Thr Ala Gln Pro Cys 
            260                 265                 270         


Asp Pro Val Ser Ser Val Phe Ala Val Cys Thr Thr Gln Asp Asp Leu 
        275                 280                 285             


Arg Leu Thr Ser Arg Thr Lys Gly Ala Cys Pro Phe Phe Asn Val Leu 
    290                 295                 300                 


Leu Arg Lys Asn Glu Ala Leu Leu Arg Leu Pro Ala Phe Gln Glu Lys 
305                 310                 315                 320 


Leu Arg Pro Leu Arg Asn Leu Cys Pro Ala Arg Leu Pro Pro Pro Ile 
                325                 330                 335     


Pro Gly Ala His Leu Ala Val Pro Gly Ser Ser Pro Ala Leu Pro Pro 
            340                 345                 350         


Ala Arg 
        


<210>  921
<211>  1506
<212>  DNA
<213>  Homosapiens

<400>  921
acccgtgggc ctgtggactg cagcctcggc gatcagagag tgcttgtgat ttcacgtatt     60

tttgctgaac tcgtaaaaga gacacttgga tggtggatta accagaacac taacattctg    120

tgaaaagttt caaattggag aatattgaat tttcacccta gtccagcagc tccgctgtca    180

cttaaataca gatgaatgaa gaccccattc ggaaagacac ctggccagcg gtccagagct    240

gatgcaggcc atgctggaag tatctgccaa catgatgaag aagaggacat cccacaaaaa    300

acatcggagc agtgtgggtc cgagcaaacc tgtttcccag ccccggcgga acatcgtagg    360

ctgcaggatt cagcatgggt ggaaagaggg gaatggccct gttacccagt ggaaagggac    420

cgttctggac caggtgcctg taaatccttc tttgtatctt ataaaatacg atggatttga    480

ctgtgtttat ggactagaac ttaataaaga tgaaagagtt tctgcgcttg aagtcctccc    540

tgatagagtt gcgacatctc gaatcagcga tgcacacttg gcagacacaa tgattggcaa    600

agcagtggaa catatgtttg agacagagga tggttctaaa gatgagtgga ggggaatggt    660

cttagcacgt gcacctgtca tgaacacatg gttttacatt acctatgaga aagaccctgt    720

cttgtacatg taccaactct tagatgatta caaagaaggc gaccttcgca ttatgcctga    780

ttccaatgat tcacctccag cagaaaggga accaggagaa gttgtggaca gcctggtagg    840

caaacaagtg gaatatgcca aagaagatgg ctcgaaaagg actggcatgg tcattcatca    900

agtagaagcc aagccctccg tctatttcat caagtttgat gatgatttcc atatttatgt    960

ctacgatttg gtgaaaacat cctagatgtc atcacaaact ctgccaaatt tgtggaacta   1020

tgaaatgtat tatttgtaga cataaagact tgattgcttt ccagtttaat gaaagcttaa   1080

atgtccctgc gaacccacaa tctctgccag cagaactggt tttgttctga atagtacaga   1140

ttgatgtgaa cacaaagcat tttgtgtaag gagaacccct ttcttttaaa agaagtctgt   1200

ctatttcgag gggagttaca ggcaagtttg gtaaaagtta agctagtatc atagtcattt   1260

aaaattgtaa tagatcttaa ccattttccc cctcacccta actctcttat tctgccgcca   1320

caatgcaagc atagtttgat gttttcgtta ttgccttttt tgagatgtat gtatctgtat   1380

ctacctatat ctatatgtgt gtatacatat ataatatata cacacagata caagtgtaca   1440

cacacacacc acacaccaca cacaccccac tggcagcttt gtggattagg atgggggtgc   1500

ggggtt                                                              1506


<210>  922
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  922

Met Gln Ala Met Leu Glu Val Ser Ala Asn Met Met Lys Lys Arg Thr 
1               5                   10                  15      


Ser His Lys Lys His Arg Ser Ser Val Gly Pro Ser Lys Pro Val Ser 
            20                  25                  30          


Gln Pro Arg Arg Asn Ile Val Gly Cys Arg Ile Gln His Gly Trp Lys 
        35                  40                  45              


Glu Gly Asn Gly Pro Val Thr Gln Trp Lys Gly Thr Val Leu Asp Gln 
    50                  55                  60                  


Val Pro Val Asn Pro Ser Leu Tyr Leu Ile Lys Tyr Asp Gly Phe Asp 
65                  70                  75                  80  


Cys Val Tyr Gly Leu Glu Leu Asn Lys Asp Glu Arg Val Ser Ala Leu 
                85                  90                  95      


Glu Val Leu Pro Asp Arg Val Ala Thr Ser Arg Ile Ser Asp Ala His 
            100                 105                 110         


Leu Ala Asp Thr Met Ile Gly Lys Ala Val Glu His Met Phe Glu Thr 
        115                 120                 125             


Glu Asp Gly Ser Lys Asp Glu Trp Arg Gly Met Val Leu Ala Arg Ala 
    130                 135                 140                 


Pro Val Met Asn Thr Trp Phe Tyr Ile Thr Tyr Glu Lys Asp Pro Val 
145                 150                 155                 160 


Leu Tyr Met Tyr Gln Leu Leu Asp Asp Tyr Lys Glu Gly Asp Leu Arg 
                165                 170                 175     


Ile Met Pro Asp Ser Asn Asp Ser Pro Pro Ala Glu Arg Glu Pro Gly 
            180                 185                 190         


Glu Val Val Asp Ser Leu Val Gly Lys Gln Val Glu Tyr Ala Lys Glu 
        195                 200                 205             


Asp Gly Ser Lys Arg Thr Gly Met Val Ile His Gln Val Glu Ala Lys 
    210                 215                 220                 


Pro Ser Val Tyr Phe Ile Lys Phe Asp Asp Asp Phe His Ile Tyr Val 
225                 230                 235                 240 


Tyr Asp Leu Val Lys Thr Ser 
                245         


<210>  923
<211>  1472
<212>  DNA
<213>  Homosapiens

<400>  923
gtgtgggcgg ggcgcagttg ggggagggtg cagagacctg agggcttgag gttgcctggc     60

tggccccgct cccagaggcg ggtgccgcgc tgtcgcccag gtatctgggg tctctggtgt    120

ctgagtgtct cattgtcggc gcgaacacaa ttgctccagc cacaggcgag gcctggccaa    180

ggtgtgggcg catctagggc aggtcttgag aggtccagcg cccggtggtg cggacagagg    240

cggggcaccg cggcgctcgc cgccgcctcc ccgcaggtga tcatcctcct gcaggtgtcc    300

tcgggtctca ggtggctgcg tgtctgcgcc atggttgaca ttctgggcga gcggcacctg    360

gtgacctgta agggcgcgac ggtggaggcc gaggcggcgc tgcagaacaa ggtggtggca    420

ctgtacttcg cggcggcccg gtgcgcgccg agccgcgact tcacgccgct gctctgcgac    480

ttctatacgg cgctggtggc cgaggcgcgg cggcccgcgc ccttcgaagt ggtcttcgtg    540

tcagccgacg gcagctgcca ggagatgctg gacttcatgc gcgagctgca tggcgcctgg    600

ctggcgctgc ccttccacga cccctaccgg caacggagtc tcgctctgtt gcccaggctg    660

gagtgcagtg gcgtgatctt agctcactgc aacctttgcc tcctgggttc aagtgattct    720

ctagccttag cctcctgagc atctgggact acagccattg ctgtgaatta cgtgagggaa    780

agatattgaa gaggagttgg acactccgag agtgcagctg ttctcccccc gcaccatccg    840

tgtcctgcat tctgcgagtc tgtgctcatt aacaatgtgc tgtgaccatg tgactcagca    900

atcctgctgc tgggtatata cccgaaagaa aggaaaagga agccagtata ttgaagaggt    960

atctgcaccc ccatgtttat tgcagcactg ttcacaacag ccaagatttg gaagcaacct   1020

aagtgtccat caacagatga atggataaag aaaacgtggt acatatacac aatggagtac   1080

tcttcagcca ttaaaaaaat gagattctgt catttgcaat aatatagatg gaaaaggagg   1140

cccttatgtg aagtgaaata agccaggcac agaaagacaa acatcacatg ttctcactta   1200

tttgtgggat ctaatgatca aaacaattga actcttggac atagagagta gaaggttggt   1260

taccagaagc tggaaaggaa agtggggttg ggaggaaggt gggaatggtt aataggtaca   1320

aaaaaataca aagaataaat aagacctaat atttgatagc acaacagtgt gactactgtc   1380

aataatcatt taattgtaca tttaaaaata actataattg cattgtttgt aacacaaaag   1440

ataaatgctt gaggagaaaa aaaaaaaaaa aa                                 1472


<210>  924
<211>  135
<212>  PRT
<213>  Homosapiens

<400>  924

Met Val Asp Ile Leu Gly Glu Arg His Leu Val Thr Cys Lys Gly Ala 
1               5                   10                  15      


Thr Val Glu Ala Glu Ala Ala Leu Gln Asn Lys Val Val Ala Leu Tyr 
            20                  25                  30          


Phe Ala Ala Ala Arg Cys Ala Pro Ser Arg Asp Phe Thr Pro Leu Leu 
        35                  40                  45              


Cys Asp Phe Tyr Thr Ala Leu Val Ala Glu Ala Arg Arg Pro Ala Pro 
    50                  55                  60                  


Phe Glu Val Val Phe Val Ser Ala Asp Gly Ser Cys Gln Glu Met Leu 
65                  70                  75                  80  


Asp Phe Met Arg Glu Leu His Gly Ala Trp Leu Ala Leu Pro Phe His 
                85                  90                  95      


Asp Pro Tyr Arg Gln Arg Ser Leu Ala Leu Leu Pro Arg Leu Glu Cys 
            100                 105                 110         


Ser Gly Val Ile Leu Ala His Cys Asn Leu Cys Leu Leu Gly Ser Ser 
        115                 120                 125             


Asp Ser Leu Ala Leu Ala Ser 
    130                 135 


<210>  925
<211>  1222
<212>  DNA
<213>  Homosapiens

<400>  925
gaaagcagga tctgtctcac catacactga gaactgtaga atatgcaagg cacatggaac     60

ttattttctt acgtataaaa gcgtgtatat gctccttata catctgtcct aatgctttcc    120

aacagtcctc actctaagcc tcaccaagac ccagatgagg aaacaaaggc acagagggat    180

aaactcagag caggaagaca gcaaggaata gcagtgaaaa gcatggtgct taatccaacc    240

ccttactcac tgctgagacc tggaaatgtg ttcatcagct acaaaacagg agagatgata    300

actcattatg tatatgtgat gataaacaga gacaatatat tgaagagctt atatgagtgg    360

cagacacggg acatgcttcc ctgtggctgg ccagcgtgtc atcttctcca tgtgtccaga    420

gaaaagcttt gcaaatcaac ctctcgatga atgatgacgg caccagtgaa atcaggggag    480

gcagaaaatc atgttagttt ggtttataat gcaagaagtt acagaacaca gagtgctcaa    540

aactaagaat gtgctagttg tataacaggg tccttcttgg gactcagcca ggattcaaac    600

tataaaggaa aatcgggtga gcaggtggga tagtcaagtg attctatttg catgaataat    660

tttgtgagat gataccttct tgtccaggaa cattgagcag tgctcgtgct gggtggattg    720

tgatgtggaa accctgggag atgtcacgtc tgacatcaac tttctcccag gtgacagctg    780

caccctctaa aggcttctca aatgacagag ctcaatgaat atagaaggga aaagtatgag    840

gatgacctat gagcacaggg tggacagtct ctgcggtggg caggcattag caaaggagag    900

accttctgta ttatgcagag tggaattttc cagaggctac atgatgagtg acgtcacgac    960

agattgagta cagagccaac tatgagaatc cagctgcctt ctattaaggt accctttctg   1020

tggatacctt caagttccag caccaaatat gaaggcgact gccatcacca gctcccaccc   1080

ctacatgagg tcaaatccct ggatggcata taacacacta gagcaattaa gaggatctaa   1140

ctaaaggtgg ggaaggaaaa atgtgtgtac agagacagga agtcatggac acagttatat   1200

tgaaagatac aatgacctcc tc                                            1222


<210>  926
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  926

Met Leu Ser Asn Ser Pro His Ser Lys Pro His Gln Asp Pro Asp Glu 
1               5                   10                  15      


Glu Thr Lys Ala Gln Arg Asp Lys Leu Arg Ala Gly Arg Gln Gln Gly 
            20                  25                  30          


Ile Ala Val Lys Ser Met Val Leu Asn Pro Thr Pro Tyr Ser Leu Leu 
        35                  40                  45              


Arg Pro Gly Asn Val Phe Ile Ser Tyr Lys Thr Gly Glu Met Ile Thr 
    50                  55                  60                  


His Tyr Val Tyr Val Met Ile Asn Arg Asp Asn Ile Leu Lys Ser Leu 
65                  70                  75                  80  


Tyr Glu Trp Gln Thr Arg Asp Met Leu Pro Cys Gly Trp Pro Ala Cys 
                85                  90                  95      


His Leu Leu His Val Ser Arg Glu Lys Leu Cys Lys Ser Thr Ser Arg 
            100                 105                 110         


<210>  927
<211>  4955
<212>  DNA
<213>  Homosapiens

<400>  927
tctcctccta ccggtcgggt gccccggggc gttccctctg ccgctgcttc tcggcgcggt     60

tcctacccgg ccgctccccg aggcgcgggc tctggcggcc tcgaccgact aggacgcccc    120

gtgcgccgcc cgcgggccgc cgcctccctg ggcgcgcggg gccagcatgg agctcttcca    180

agccaaggac cactacatcc tgcagcaggg cgagcgcgcg ctgtggtgca gccgccgcga    240

cggcggcctc cagctccgac ccgctactga tctacttctt gcctggaatc ccatttgttt    300

ggggttggta gaaggtgtta ttgggaaaat tcaacttcat tcagatcttc catggtggct    360

tattctaatt cggcagaaag cattggtggg caaactccca ggagaccatg aggtctgtaa    420

agttaccaaa attgctgtgc tctcactttc tgaaatggaa cctcaggatc ttgagctaga    480

gctctgtaag aagcatcatt ttggtattaa caaaccagag aagatcatac catctcctga    540

tgactcaaag tttctactga agacctttac gcatattaaa tccaatgtgt ctgctcctaa    600

taaaaagaaa gttaaggaaa gtaaagagaa ggagaagttg gagaggagat tacttgaaga    660

gttgctgaag atgttcatgg actcagaatc cttttattat agcttgacct atgacctgac    720

caattccgtg cagaggcaga gcactgggga gagggacggt cggcccctct ggcagaaggt    780

tgatgaccga tttttttgga ataaatacat gatacaagat cttactgaga ttggtactcc    840

agatgtggac ttttggatta tccccatgat ccaaggtttt gtgcagattg aagaacttgt    900

ggttaattat accgaatcat ctgatgatga gaaaagcagc ccagagaccc cccctcagga    960

gtccacctgt gtagatgata ttcacccacg atttctagtg gctctcattt cacgccgaag   1020

taggcacaga gcaggaatgc gctataaacg aagaggagtg gataaaaatg gaaatgttgc   1080

caattatgtg gagactgagc agttgattca tgttcataat cataccctgt catttgttca   1140

aacacgaggc tctgtgcctg tcttttggag ccaggttggg tatcgatata acccaagacc   1200

gcggctggac agaagtgaaa aggaaactgt tgcctatttc tgtgcccatt tcgaagaaca   1260

actgaacatt tacaaaaaac aggttattat taacttggta gaccaggcag gaagagagaa   1320

gattattggc gatgcttacc tgaagcaagt gttgcttttc aacaactcac acctcactta   1380

cgtttcgttt gacttccatg agcactgccg aggaatgaag tttgagaatg ttcagacact   1440

aacagatgcc atttatgaca ttattcttga tatgaagtgg tgttgggttg atgaagctgg   1500

ggtaatatgt aagcaggaag ggatttttcg tgttaattgt atggactgcc tggatcgcac   1560

caacgtggtc caagctgcca tcgcgagagt ggtcatggaa cagcagctga aaaaattagg   1620

tgtgatgccc ccggaacagc cattacctgt gaaatgtaat cgcatctacc agataatgtg   1680

ggccaataat ggtgactcca ttagcagaca gtatgctggg acagctgctc tgaagggtga   1740

ctttacaagg acaggagaaa ggaagttagc aggagttatg aaagatggag tgaactcagc   1800

aaacagatat tacctcaacc gatttaagga tgcttatagg caagctgtta tagatttgat   1860

gcaaggcatt ccagtgacag aagatcttta ttccatattt accaaggaga aagaacatga   1920

agctttgcat aaggaaaatc agagaagcca ccaggaacta attagccagc tcttacaaag   1980

ttacatgaag ttactactgc ctgatgatga gaagttccat gggggctggg ccctcattga   2040

ctgtgaccct agcctcattg atgctactca cagagacgtg gatgtgctgt tactgctttc   2100

taactctgcc tactacgtgg cctattatga tgatgaagtt gataaagtaa accagtatca   2160

acgactaagt ctagaaaacc tggaaaaaat tgaaataggc cctgaaccca ctctttttgg   2220

taagccaaag ttctcctgca tgcgactgca ctacagatac aaagaagcga gtggctattt   2280

ccacacattg cgagctgtaa tgcgtaatcc tgaagaggat ggaaaagata cccttcagtg   2340

cattgcagag atgctgcaga tcaccaagca agccatggga tcggatttac ccataattga   2400

gaagaaactt gagaggaaga gcagtaaacc tcacgaagac atcattggta tcaggtctca   2460

aaaccaaggt tctttggccc agggaaagaa ttttttaatg agcaaatttt catctctaaa   2520

tcaaaaagtg aagcagacca aatccaatgt aaatattggc aacctccgaa agctaggaaa   2580

ctttaccaaa cctgaaatga aagttaactt tctaaaacca aacttaaaag taaatctttg   2640

gaaatcagat agtagtcttg aaactatgga aaacacagga gtgatggata aggttcaggc   2700

agagtctgat ggggacatgt cttcagataa tgactcatac cactctgatg aattccttac   2760

aaattctaag tctgatgaag acaggcagct agctaactca ttagagagtg tagggccaat   2820

agattacgtt cttcctagtt gtggtattat tgcctcagcg cctcgattgg gcagtcggtc   2880

ccagtctctt agcagcacag atagtagcgt tcatgctcct tcagagatta ctgttgctca   2940

tgggagtggg cttggaaaag gccaggagtc tcctttgaag aaaagtcctt ctgctggcga   3000

cgtacacata ttgactggct ttgccaagcc tatggatatt tactgccaca gatttgtgca   3060

agatgcacag aacaaagtga cccacctatc agagaccaga tctgtgtctc agcaggctag   3120

tcaggaaaga aatcaaatga ccaatcaagt ttcaaatgaa acccaatcag aatcaacaga   3180

acagacacct tctcggccat cgcaattaga tgtctctctt tctgcaacag gcccacagtt   3240

tttgtcagtt gagccagcgc attcagttgc atctcaaaaa acccccacct ccgcttccag   3300

catgcttgaa cttgagacag ggcttcatgt aactccttct ccttcagaga gcagtagcag   3360

cagagcagtc tctccctttg ccaagattcg aagttccatg gtccaggttg ctagtattac   3420

ccaagctgga ttaacccatg ggataaactt tgcagtgtca aaagttcaga agagtcctcc   3480

agaacctgaa atcattaatc aagtccagca aaatgaactt aaaaagatgt ttatacaatg   3540

ccagacacgg ataattcaga tttagctttt agccataaga atccttccat ggcttttatt   3600

taaaaatatg aaattttcac ctcttggggt attttaattg tactgtctga acccagggat   3660

cacaaattct gttcattgga aagggtttta aacggagtcg gaacctgagt agatttccaa   3720

attttacagc caggactaca gaagtgcatc attctagaat gtgtagacct gagtagctta   3780

tacactacag agcactttgc ttatttgaaa gtaattcagc aacaggtcac tttgggatat   3840

aacctgaacc tttttttgga gtggggtggg tagactacag tagacacaag ggctggacat   3900

gcagatgctt aggggattag cgtttttcat aatttgttct gtttgtcagt tcattcctgt   3960

gtgttcttac ctctacaaag taaattacac atttagtttt tagtgacttt aacatgttac   4020

tgaagcattt gaatataaag ctattttagt tttgatggct taactgttcc ctgaggagtt   4080

gagggttatt gacactagag aaatgaattc tcatttgatc ctaattttcc ccgtattcta   4140

cttgaacaca ttaaaaatac tctgctgcct atacaatgta aacctaggag cattaagact   4200

tgtcacacag taaacctgat acatcagagg tgaataccag cacctattag gtttcatttt   4260

gctgttttca ggaatgtaag aacacccata ttggctactg gaaattctag aagtcagtca   4320

ggttttaatt tattccagga ggggcatcct cgacatctta tgtagatgat ccacaacttc   4380

aaaatttagt ctgggcctag tgcagtggct cacacctata atcccaacac tttgggaggc   4440

caggagtttt gagaccagcc tgggaaacat ctgtctctac aaaaaaatac aaaaattagc   4500

tgggcatagt ggtgcatgcc tgtgtttcta gctacgcagg aggattgctt gagcccatga   4560

gattgaggct gcagtgagct gtgatcgtgc cactgacctc cagcctgggg gacagagcaa   4620

gaccgtgtct caaaaacaat ttagtctgaa acacaattgt gctgaatctg tctgactata   4680

actctgacca cacagaacca gggctgcccc tgtaatcccc acagtaagaa agttgtatgg   4740

catattccaa caagtattgg ttcgtctggt gtctttagag ctttactctg ttgaagtgac   4800

tgattctcaa ctgaacatta tgtcgttact ttgataagca ttccactttt gttatttatt   4860

agtgctatct ttttttttta cgtgttaaat cttgtgatta ttaaaataaa gtaccattgt   4920

aatttaaagt gaaaaaaaaa aaaaaaaaaa aaaaa                              4955


<210>  928
<211>  1132
<212>  PRT
<213>  Homosapiens

<400>  928

Met Glu Leu Phe Gln Ala Lys Asp His Tyr Ile Leu Gln Gln Gly Glu 
1               5                   10                  15      


Arg Ala Leu Trp Cys Ser Arg Arg Asp Gly Gly Leu Gln Leu Arg Pro 
            20                  25                  30          


Ala Thr Asp Leu Leu Leu Ala Trp Asn Pro Ile Cys Leu Gly Leu Val 
        35                  40                  45              


Glu Gly Val Ile Gly Lys Ile Gln Leu His Ser Asp Leu Pro Trp Trp 
    50                  55                  60                  


Leu Ile Leu Ile Arg Gln Lys Ala Leu Val Gly Lys Leu Pro Gly Asp 
65                  70                  75                  80  


His Glu Val Cys Lys Val Thr Lys Ile Ala Val Leu Ser Leu Ser Glu 
                85                  90                  95      


Met Glu Pro Gln Asp Leu Glu Leu Glu Leu Cys Lys Lys His His Phe 
            100                 105                 110         


Gly Ile Asn Lys Pro Glu Lys Ile Ile Pro Ser Pro Asp Asp Ser Lys 
        115                 120                 125             


Phe Leu Leu Lys Thr Phe Thr His Ile Lys Ser Asn Val Ser Ala Pro 
    130                 135                 140                 


Asn Lys Lys Lys Val Lys Glu Ser Lys Glu Lys Glu Lys Leu Glu Arg 
145                 150                 155                 160 


Arg Leu Leu Glu Glu Leu Leu Lys Met Phe Met Asp Ser Glu Ser Phe 
                165                 170                 175     


Tyr Tyr Ser Leu Thr Tyr Asp Leu Thr Asn Ser Val Gln Arg Gln Ser 
            180                 185                 190         


Thr Gly Glu Arg Asp Gly Arg Pro Leu Trp Gln Lys Val Asp Asp Arg 
        195                 200                 205             


Phe Phe Trp Asn Lys Tyr Met Ile Gln Asp Leu Thr Glu Ile Gly Thr 
    210                 215                 220                 


Pro Asp Val Asp Phe Trp Ile Ile Pro Met Ile Gln Gly Phe Val Gln 
225                 230                 235                 240 


Ile Glu Glu Leu Val Val Asn Tyr Thr Glu Ser Ser Asp Asp Glu Lys 
                245                 250                 255     


Ser Ser Pro Glu Thr Pro Pro Gln Glu Ser Thr Cys Val Asp Asp Ile 
            260                 265                 270         


His Pro Arg Phe Leu Val Ala Leu Ile Ser Arg Arg Ser Arg His Arg 
        275                 280                 285             


Ala Gly Met Arg Tyr Lys Arg Arg Gly Val Asp Lys Asn Gly Asn Val 
    290                 295                 300                 


Ala Asn Tyr Val Glu Thr Glu Gln Leu Ile His Val His Asn His Thr 
305                 310                 315                 320 


Leu Ser Phe Val Gln Thr Arg Gly Ser Val Pro Val Phe Trp Ser Gln 
                325                 330                 335     


Val Gly Tyr Arg Tyr Asn Pro Arg Pro Arg Leu Asp Arg Ser Glu Lys 
            340                 345                 350         


Glu Thr Val Ala Tyr Phe Cys Ala His Phe Glu Glu Gln Leu Asn Ile 
        355                 360                 365             


Tyr Lys Lys Gln Val Ile Ile Asn Leu Val Asp Gln Ala Gly Arg Glu 
    370                 375                 380                 


Lys Ile Ile Gly Asp Ala Tyr Leu Lys Gln Val Leu Leu Phe Asn Asn 
385                 390                 395                 400 


Ser His Leu Thr Tyr Val Ser Phe Asp Phe His Glu His Cys Arg Gly 
                405                 410                 415     


Met Lys Phe Glu Asn Val Gln Thr Leu Thr Asp Ala Ile Tyr Asp Ile 
            420                 425                 430         


Ile Leu Asp Met Lys Trp Cys Trp Val Asp Glu Ala Gly Val Ile Cys 
        435                 440                 445             


Lys Gln Glu Gly Ile Phe Arg Val Asn Cys Met Asp Cys Leu Asp Arg 
    450                 455                 460                 


Thr Asn Val Val Gln Ala Ala Ile Ala Arg Val Val Met Glu Gln Gln 
465                 470                 475                 480 


Leu Lys Lys Leu Gly Val Met Pro Pro Glu Gln Pro Leu Pro Val Lys 
                485                 490                 495     


Cys Asn Arg Ile Tyr Gln Ile Met Trp Ala Asn Asn Gly Asp Ser Ile 
            500                 505                 510         


Ser Arg Gln Tyr Ala Gly Thr Ala Ala Leu Lys Gly Asp Phe Thr Arg 
        515                 520                 525             


Thr Gly Glu Arg Lys Leu Ala Gly Val Met Lys Asp Gly Val Asn Ser 
    530                 535                 540                 


Ala Asn Arg Tyr Tyr Leu Asn Arg Phe Lys Asp Ala Tyr Arg Gln Ala 
545                 550                 555                 560 


Val Ile Asp Leu Met Gln Gly Ile Pro Val Thr Glu Asp Leu Tyr Ser 
                565                 570                 575     


Ile Phe Thr Lys Glu Lys Glu His Glu Ala Leu His Lys Glu Asn Gln 
            580                 585                 590         


Arg Ser His Gln Glu Leu Ile Ser Gln Leu Leu Gln Ser Tyr Met Lys 
        595                 600                 605             


Leu Leu Leu Pro Asp Asp Glu Lys Phe His Gly Gly Trp Ala Leu Ile 
    610                 615                 620                 


Asp Cys Asp Pro Ser Leu Ile Asp Ala Thr His Arg Asp Val Asp Val 
625                 630                 635                 640 


Leu Leu Leu Leu Ser Asn Ser Ala Tyr Tyr Val Ala Tyr Tyr Asp Asp 
                645                 650                 655     


Glu Val Asp Lys Val Asn Gln Tyr Gln Arg Leu Ser Leu Glu Asn Leu 
            660                 665                 670         


Glu Lys Ile Glu Ile Gly Pro Glu Pro Thr Leu Phe Gly Lys Pro Lys 
        675                 680                 685             


Phe Ser Cys Met Arg Leu His Tyr Arg Tyr Lys Glu Ala Ser Gly Tyr 
    690                 695                 700                 


Phe His Thr Leu Arg Ala Val Met Arg Asn Pro Glu Glu Asp Gly Lys 
705                 710                 715                 720 


Asp Thr Leu Gln Cys Ile Ala Glu Met Leu Gln Ile Thr Lys Gln Ala 
                725                 730                 735     


Met Gly Ser Asp Leu Pro Ile Ile Glu Lys Lys Leu Glu Arg Lys Ser 
            740                 745                 750         


Ser Lys Pro His Glu Asp Ile Ile Gly Ile Arg Ser Gln Asn Gln Gly 
        755                 760                 765             


Ser Leu Ala Gln Gly Lys Asn Phe Leu Met Ser Lys Phe Ser Ser Leu 
    770                 775                 780                 


Asn Gln Lys Val Lys Gln Thr Lys Ser Asn Val Asn Ile Gly Asn Leu 
785                 790                 795                 800 


Arg Lys Leu Gly Asn Phe Thr Lys Pro Glu Met Lys Val Asn Phe Leu 
                805                 810                 815     


Lys Pro Asn Leu Lys Val Asn Leu Trp Lys Ser Asp Ser Ser Leu Glu 
            820                 825                 830         


Thr Met Glu Asn Thr Gly Val Met Asp Lys Val Gln Ala Glu Ser Asp 
        835                 840                 845             


Gly Asp Met Ser Ser Asp Asn Asp Ser Tyr His Ser Asp Glu Phe Leu 
    850                 855                 860                 


Thr Asn Ser Lys Ser Asp Glu Asp Arg Gln Leu Ala Asn Ser Leu Glu 
865                 870                 875                 880 


Ser Val Gly Pro Ile Asp Tyr Val Leu Pro Ser Cys Gly Ile Ile Ala 
                885                 890                 895     


Ser Ala Pro Arg Leu Gly Ser Arg Ser Gln Ser Leu Ser Ser Thr Asp 
            900                 905                 910         


Ser Ser Val His Ala Pro Ser Glu Ile Thr Val Ala His Gly Ser Gly 
        915                 920                 925             


Leu Gly Lys Gly Gln Glu Ser Pro Leu Lys Lys Ser Pro Ser Ala Gly 
    930                 935                 940                 


Asp Val His Ile Leu Thr Gly Phe Ala Lys Pro Met Asp Ile Tyr Cys 
945                 950                 955                 960 


His Arg Phe Val Gln Asp Ala Gln Asn Lys Val Thr His Leu Ser Glu 
                965                 970                 975     


Thr Arg Ser Val Ser Gln Gln Ala Ser Gln Glu Arg Asn Gln Met Thr 
            980                 985                 990         


Asn Gln Val Ser Asn Glu Thr Gln  Ser Glu Ser Thr Glu  Gln Thr Pro 
        995                 1000                 1005             


Ser Arg  Pro Ser Gln Leu Asp  Val Ser Leu Ser Ala  Thr Gly Pro 
    1010                 1015                 1020             


Gln Phe  Leu Ser Val Glu Pro  Ala His Ser Val Ala  Ser Gln Lys 
    1025                 1030                 1035             


Thr Pro  Thr Ser Ala Ser Ser  Met Leu Glu Leu Glu  Thr Gly Leu 
    1040                 1045                 1050             


His Val  Thr Pro Ser Pro Ser  Glu Ser Ser Ser Ser  Arg Ala Val 
    1055                 1060                 1065             


Ser Pro  Phe Ala Lys Ile Arg  Ser Ser Met Val Gln  Val Ala Ser 
    1070                 1075                 1080             


Ile Thr  Gln Ala Gly Leu Thr  His Gly Ile Asn Phe  Ala Val Ser 
    1085                 1090                 1095             


Lys Val  Gln Lys Ser Pro Pro  Glu Pro Glu Ile Ile  Asn Gln Val 
    1100                 1105                 1110             


Gln Gln  Asn Glu Leu Lys Lys  Met Phe Ile Gln Cys  Gln Thr Arg 
    1115                 1120                 1125             


Ile Ile  Gln Ile 
    1130         


<210>  929
<211>  3167
<212>  DNA
<213>  Homosapiens

<400>  929
aatatttact gcagctaaga cttcagtaaa attgggggtg gggggagggt tgacattttc     60

cgactgcctg ttacgtgcca agtgcttttt gttaaggaca taatgttttt gactggggat    120

catgtttggc tgatgtaaat attaatgcca aaataggagc taggatgaaa gtaacactgt    180

aattagtagt agaatttatt tcatattaaa atgtgtcatg acgtaatttt tatggcttgg    240

ctcaagcaac aattttcaga gtgcaccctc attgatgcta ctcacagaga cgtggatgtg    300

ctgttactgc tttctaactc tgcctactac gtggcctaat gatgatgaag ttgataaagt    360

aaaccagtat caacgactaa gtctagaaaa cctggaaaaa attgaaatag gccctgaacc    420

cactcttttt ggtaagccaa agttctcctg catgcgactg cactacagat acaaagaagc    480

gagtggctat ttccacacat tgcgagctgt aatgcgtaat cctgaagagg atggaaaaga    540

tacccttcag tgcattgcag agatgctgca gatcaccaag caagccatgg gatcggattt    600

acccataatt gagaagaaac ttgagaggaa gagcagtaaa cctcacgaag acatcattgg    660

tatcaggtct caaaaccaag gttctttggc ccagggaaag aattttttaa tgagcaaatt    720

ttcatctcta aatcaaaaag tgaagcagac caaatccaat gtaaatattg gcaacctccg    780

aaagctagga aactttacca aacctgaaat gaaagttaac tttctaaaac caaacttaaa    840

agtaaatctt tggaaatcag atagtagtct tgaaactatg gaaaacacag gagtgatgga    900

taaggttcag gcagagtctg atggggacat gtcttcagat aatgactcat accactctga    960

tgaattcctt acaaattcta agtctgatga agacaggcag ctagctaact cattagagag   1020

tgtagggcca atagattacg ttcttcctag ttgtggtatt attgcctcag cgcctcgatt   1080

gggcagtcgg tcccagtctc ttagcagcac agatagtagc gttcatgctc cttcagagat   1140

tactgttgct catgggagtg ggcttggaaa aggccaggag tctcctttga agaaaagtcc   1200

ttctgctggc gacgtacaca tattgactgg ctttgccaag cctatggata tttactgcca   1260

cagatttgtg caagatgcac agaacaaagt gacccaccta tcagagacca gatctgtgtc   1320

tcagcaggct agtcaggaaa gaaatcaaat gaccaatcaa gtttcaaatg aaacccaatc   1380

agaatcaaca gaacagacac cttctcggcc atcgcaatta gatgtctctc tttctgcaac   1440

aggcccacag tttttgtcag ttgagccagc gcattcagtt gcatctcaaa aaacccccac   1500

ctccgcttcc agcatgcttg aacttgagac agggcttcat gtaactcctt ctccttcaga   1560

gagcagtagc agcagagcag tctctccctt tgccaagatt cgaagttcca tggtccaggt   1620

tgctagtatt acccaagctg gattaaccca tgggataaac tttgcagtgt caaaagttca   1680

gaagagtcct ccagaacctg aaatcattaa tcaagtccag caaaatgaac ttaaaaagat   1740

gtttatacaa tgccagacac ggataattca gatttagctt ttagccataa gaatccttcc   1800

atggctttta tttaaaaata tgaaattttc acctcttggg gtattttaat tgtactgtct   1860

gaacccaggg atcacaaatt ctgttcattg gaaagggttt taaacggagt cggaacctga   1920

gtagatttcc aaattttaca gccaggacta cagaagtgca tcattctaga atgtgtagac   1980

ctgagtagct tatacactac agagcacttt gcttatttga aagtaattca gcaacaggtc   2040

actttgggat ataacctgaa cctttttttg gagtggggtg ggtagactac agtagacaca   2100

agggctggac atgcagatgc ttaggggatt agcgtttttc ataatttgtt ctgtttgtca   2160

gttcattcct gtgtgttctt acctctacaa agtaaattac acatttagtt tttagtgact   2220

ttaacatgtt actgaagcat ttgaatataa agctatttta gttttgatgg cttaactgtt   2280

ccctgaggag ttgagggtta ttgacactag agaaatgaat tctcatttga tcctaatttt   2340

ccccgtattc tacttgaaca cattaaaaat actctgctgc ctatacaatg taaacctagg   2400

agcattaaga cttgtcacac agtaaacctg atacatcaga ggtgaatacc agcacctatt   2460

aggtttcatt ttgctgtttt caggaatgta agaacaccca tattggctac tggaaattct   2520

agaagtcagt caggttttaa tttattccag gaggggcatc ctcgacatct tatgtagatg   2580

atccacaact tcaaaattta gtctgggcct agtgcagtgg ctcacaccta taatcccaac   2640

actttgggag gccaggagtt ttgagaccag cctgggaaac atctgtctct acaaaaaaat   2700

acaaaaatta gctgggcata gtggtgcatg cctgtgtttc tagctacgca ggaggattgc   2760

ttgagcccat gagattgagg ctgcagtgag ctgtgatcgt gccactgacc tccagcctgg   2820

gggacagagc aagaccgtgt ctcaaaaaca atttagtctg aaacacaatt gtgctgaatc   2880

tgtctgacta taactctgac cacacagaac cagggctgcc cctgtaatcc ccacagtaag   2940

aaagttgtat ggcatattcc aacaagtatt ggttcgtctg gtgtctttag agctttactc   3000

tgttgaagtg actgattctc aactgaacat tatgtcgtta ctttgataag cattccactt   3060

ttgttattta ttagtgctat cttttttttt tacgtgttaa atcttgtgat tattaaaata   3120

aagtaccatt gtaatttaaa gtgaaaaaaa aaaaaaaaaa aaaaaaa                 3167


<210>  930
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  930

Met Leu Leu Thr Glu Thr Trp Met Cys Cys Tyr Cys Phe Leu Thr Leu 
1               5                   10                  15      


Pro Thr Thr Trp Pro Asn Asp Asp Glu Val Asp Lys Val Asn Gln Tyr 
            20                  25                  30          


Gln Arg Leu Ser Leu Glu Asn Leu Glu Lys Ile Glu Ile Gly Pro Glu 
        35                  40                  45              


Pro Thr Leu Phe Gly Lys Pro Lys Phe Ser Cys Met Arg Leu His Tyr 
    50                  55                  60                  


Arg Tyr Lys Glu Ala Ser Gly Tyr Phe His Thr Leu Arg Ala Val Met 
65                  70                  75                  80  


Arg Asn Pro Glu Glu Asp Gly Lys Asp Thr Leu Gln Cys Ile Ala Glu 
                85                  90                  95      


Met Leu Gln Ile Thr Lys Gln Ala Met Gly Ser Asp Leu Pro Ile Ile 
            100                 105                 110         


Glu Lys Lys Leu Glu Arg Lys Ser Ser Lys Pro His Glu Asp Ile Ile 
        115                 120                 125             


Gly Ile Arg Ser Gln Asn Gln Gly Ser Leu Ala Gln Gly Lys Asn Phe 
    130                 135                 140                 


Leu Met Ser Lys Phe Ser Ser Leu Asn Gln Lys Val Lys Gln Thr Lys 
145                 150                 155                 160 


Ser Asn Val Asn Ile Gly Asn Leu Arg Lys Leu Gly Asn Phe Thr Lys 
                165                 170                 175     


Pro Glu Met Lys Val Asn Phe Leu Lys Pro Asn Leu Lys Val Asn Leu 
            180                 185                 190         


Trp Lys Ser Asp Ser Ser Leu Glu Thr Met Glu Asn Thr Gly Val Met 
        195                 200                 205             


Asp Lys Val Gln Ala Glu Ser Asp Gly Asp Met Ser Ser Asp Asn Asp 
    210                 215                 220                 


Ser Tyr His Ser Asp Glu Phe Leu Thr Asn Ser Lys Ser Asp Glu Asp 
225                 230                 235                 240 


Arg Gln Leu Ala Asn Ser Leu Glu Ser Val Gly Pro Ile Asp Tyr Val 
                245                 250                 255     


Leu Pro Ser Cys Gly Ile Ile Ala Ser Ala Pro Arg Leu Gly Ser Arg 
            260                 265                 270         


Ser Gln Ser Leu Ser Ser Thr Asp Ser Ser Val His Ala Pro Ser Glu 
        275                 280                 285             


Ile Thr Val Ala His Gly Ser Gly Leu Gly Lys Gly Gln Glu Ser Pro 
    290                 295                 300                 


Leu Lys Lys Ser Pro Ser Ala Gly Asp Val His Ile Leu Thr Gly Phe 
305                 310                 315                 320 


Ala Lys Pro Met Asp Ile Tyr Cys His Arg Phe Val Gln Asp Ala Gln 
                325                 330                 335     


Asn Lys Val Thr His Leu Ser Glu Thr Arg Ser Val Ser Gln Gln Ala 
            340                 345                 350         


Ser Gln Glu Arg Asn Gln Met Thr Asn Gln Val Ser Asn Glu Thr Gln 
        355                 360                 365             


Ser Glu Ser Thr Glu Gln Thr Pro Ser Arg Pro Ser Gln Leu Asp Val 
    370                 375                 380                 


Ser Leu Ser Ala Thr Gly Pro Gln Phe Leu Ser Val Glu Pro Ala His 
385                 390                 395                 400 


Ser Val Ala Ser Gln Lys Thr Pro Thr Ser Ala Ser Ser Met Leu Glu 
                405                 410                 415     


Leu Glu Thr Gly Leu His Val Thr Pro Ser Pro Ser Glu Ser Ser Ser 
            420                 425                 430         


Ser Arg Ala Val Ser Pro Phe Ala Lys Ile Arg Ser Ser Met Val Gln 
        435                 440                 445             


Val Ala Ser Ile Thr Gln Ala Gly Leu Thr His Gly Ile Asn Phe Ala 
    450                 455                 460                 


Val Ser Lys Val Gln Lys Ser Pro Pro Glu Pro Glu Ile Ile Asn Gln 
465                 470                 475                 480 


Val Gln Gln Asn Glu Leu Lys Lys Met Phe Ile Gln Cys Gln Thr Arg 
                485                 490                 495     


Ile Ile Gln Ile 
            500 


<210>  931
<211>  951
<212>  DNA
<213>  Homosapiens

<400>  931
tctcctccta ccggtcgggt gccccggggc gttccctctg ccgctgcttc tcggcgcggt     60

tcctacccgg ccgctccccg aggcgcgggc tctggcggcc tcgaccgact aggacgcccc    120

gtgcgccgcc cgcgggccgc cgcctccctg ggcgcgcggg gccagcatgg agctcttcca    180

agccaaggac cactacatcc tgcagcaggg cgagcgcgcg ctgtggtgca gccgccgcga    240

cggcggcctc cagctccgac ccgctactga tctacttctt gcctggaatc ccatttgttt    300

ggggttggta gaaggtgtta ttgggaaaat tcaacttcat tcagatcttc catggtggct    360

tattctaatt cggcagaaag cattggtggg caaactccca ggagaccatg aggtctgtaa    420

agttaccaaa attgctgtgc tctcactttc tgaaatggaa cctcaggatc ttgagctaga    480

gctctgtaag aagcatcatt ttggtattaa caaaccagag aagatcatac catctcctga    540

tgactcaaag tttctactga agacctttac gcatattaaa tccaatgtgt ctgctcctaa    600

taaaaagaaa gttaaggaaa gtaaagagaa ggagaagttg gagaggagat tacttgaaga    660

gttgctgaag atgttcatgg actcagaatc cttttattat agcttgacct atgacctgac    720

caattccgtg cagaggcaga gcactgggga gagggacggt cggcccctct ggcagaaggt    780

accactcaca gctcgtagag cagggtttgc acttgggaag aagtgatggc ctgttttggc    840

ttttgtagga aaactgaaat aatgtgtttc tgaactattg ttcctgcacc ttttctaggt    900

tgatgaccga tttttttgga ataaatacat gatacaagat cttactgaga a             951


<210>  932
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  932

Met Glu Leu Phe Gln Ala Lys Asp His Tyr Ile Leu Gln Gln Gly Glu 
1               5                   10                  15      


Arg Ala Leu Trp Cys Ser Arg Arg Asp Gly Gly Leu Gln Leu Arg Pro 
            20                  25                  30          


Ala Thr Asp Leu Leu Leu Ala Trp Asn Pro Ile Cys Leu Gly Leu Val 
        35                  40                  45              


Glu Gly Val Ile Gly Lys Ile Gln Leu His Ser Asp Leu Pro Trp Trp 
    50                  55                  60                  


Leu Ile Leu Ile Arg Gln Lys Ala Leu Val Gly Lys Leu Pro Gly Asp 
65                  70                  75                  80  


His Glu Val Cys Lys Val Thr Lys Ile Ala Val Leu Ser Leu Ser Glu 
                85                  90                  95      


Met Glu Pro Gln Asp Leu Glu Leu Glu Leu Cys Lys Lys His His Phe 
            100                 105                 110         


Gly Ile Asn Lys Pro Glu Lys Ile Ile Pro Ser Pro Asp Asp Ser Lys 
        115                 120                 125             


Phe Leu Leu Lys Thr Phe Thr His Ile Lys Ser Asn Val Ser Ala Pro 
    130                 135                 140                 


Asn Lys Lys Lys Val Lys Glu Ser Lys Glu Lys Glu Lys Leu Glu Arg 
145                 150                 155                 160 


Arg Leu Leu Glu Glu Leu Leu Lys Met Phe Met Asp Ser Glu Ser Phe 
                165                 170                 175     


Tyr Tyr Ser Leu Thr Tyr Asp Leu Thr Asn Ser Val Gln Arg Gln Ser 
            180                 185                 190         


Thr Gly Glu Arg Asp Gly Arg Pro Leu Trp Gln Lys Val Pro Leu Thr 
        195                 200                 205             


Ala Arg Arg Ala Gly Phe Ala Leu Gly Lys Lys 
    210                 215                 


<210>  933
<211>  4113
<212>  DNA
<213>  Homosapiens

<400>  933
tgaggcgcgg gaggcccgcg ccccgcggct cgctgtgcgt gggagggcgc gagcgaacgc     60

gggcgaggag cggccgagcc gctgaagagg agctgggcgc cggccgcccg gccgcgctcg    120

gcccgcggat cgcctccgcc cggtcttcgc cggccccggc ccctggcgag atgccgtgtg    180

gggaggattg gctcagccac ccgctgggaa tcgtgcaggg attcttcgcc caaaatggag    240

ttaatcctga ctgggagaag aaagtaattg agtattttaa ggaaaagctg aaggaaaata    300

atgctcctaa gtgggtacca tcactgaacg aagttcccct tcattatttg aaacctaata    360

gttttgtgaa atttcgttgc atgattcagg atatgtttga ccctgagttt tacatgggag    420

tttatgaaac ggttaaccaa aacacaaaag cacatgttct tcattttgga aaatatagag    480

atgtagcaga gtgtgggcct caacaagaac ttgatttaaa ctctccacga aataccactt    540

tggaaagaca gactttctat tgtgttccgg tgcctgggga atctacgtgg gtaaaagaag    600

cctatgttaa tgcaaaccaa gctcgagtca gtccctcaac atcctacact cctagtcgcc    660

acaagaggag ttatgaagat gatgacgata tggacctaca gcccaataag cagaaagacc    720

aacatgcagg tgccagacaa gcagggagtg ttggtggtct tcaatggtgt ggagagccaa    780

aacgtttaga aactgaagct tctactgggc aacagctgaa ctctctgaac ttgtcttctc    840

cttttgattt gaattttcca ttgccaggag agaagggccc tgcatgcctt gtgaaggttt    900

atgaagattg ggattgtttc aaagtaaatg acattcttga gctatatggc atactgtctg    960

tggatcctgt gctgagtata ctgaataatg atgaaaggga tgcctctgca ctgctggatc   1020

cgatggagtg cacagacaca gcagaggagc agagagtaca cagtcctcct gcttcattag   1080

tgccgagaat tcatgtgatc ttagcccaga agttgcaaca catcaaccca ttattgcctg   1140

cctgccttaa caaagaggag agcaaaacct gtaagtttgt ttcaagtttc atgtccgaat   1200

tgtctccagt cagagcagaa cttcttgggt tccttactca tgcccttctg ggggatagtt   1260

tggctgctga ataccttata ttacatctca tctccacagt atatacaaga agagatgtcc   1320

ttccactagg aaaatttaca gttaacttga gtggttgccc acggaatagt accttcacag   1380

aacacttgta tcgaattatt caacatcttg ttccagcatc ttttcgtctg cagatgacta   1440

tagagaacat gaaccatttg aaattcattc cccacaaaga ctacacagcc aatcgcttgg   1500

tcagtgggct cctccagctg cccagcaata cttcccttgt aatcgatgag actctcctgg   1560

aacaggggca gctggatacc ccaggtgttc ataatgtgac agccctgagc aacctcataa   1620

cgtggcagaa ggtggattat gacttcagct accatcagat ggaattcccc tgcaatatta   1680

acgttttcat tacttcggag gggaggtcac tcctcccggc agactgccag attcacttac   1740

agccccagct aattccacca aacatggagg agtacatgaa cagccttctc tcagcggtgc   1800

tgccttccgt gctgaacaaa ttccgcattt atctaactct tttgagattc ttggaatata   1860

gcatatctga tgaaataacc aaggcagttg aagatgactt tgtggaaatg cggaagaacg   1920

accctcagag catcactgct gatgatcttc accagctgct cgtggtggct cggtgtctgt   1980

ctctcagtgc tggtcagaca acgctgtcaa gagaacgatg gctgagagca aagcagctag   2040

agtctttaag aagaacgagg cttcagcagc aaaaatgtgt gaatggaaat gaactttaaa   2100

gatgtaatac ctatgaagag taatgggcaa actgtagcca cataattgta aaattcagat   2160

attcatttat accacattgt tttataggta atttctatca caaaccagtg acatttcctg   2220

aaatcaagcc tggtaacacc tgatgtttat atgatattca gtaaggactt ttaccttact   2280

gatttcatgg agcttttgaa gtttgtttta taataattat ataaattagt aatgatgtaa   2340

aaaaagtatt tgatattaaa agtttaatat tgataatgtt gctgattgta ccatttcctt   2400

agcttcagct gagtcatagg ccagactgtt gaaatgctga aatgaagaag gttgttgcag   2460

tttcaaagtc agaggaatcg tgcttcggat ttcttatgtt ttctagttct ctgtttttcc   2520

agttcacagt gggttggggt gcattcagta gtccatcttt ggggaacgga ggcgtacttg   2580

ccattgattc acatgactac atgaaattct gtactgtcat ttcccagatg tttggccaca   2640

gaaacttttt cccacttaac atttgttaac agcctgcaaa actaaacttg tacatggcag   2700

tggttcccag acttttgtat tttatggacc ggtagtaata tttccaaaaa tctggggtac   2760

tataaggttg ccaatttacc ttgccaagta atccgaataa atcactgtat tatcaccatt   2820

tttttcataa aaggaaagga caatctatct ctgaataaga ggagtccttt aaacggaatg   2880

aatgtggctt ttgggggcaa aagaaaccaa gacactacat tgtctttatt ttctcctatc   2940

ccagtgcatt tgagaaccat gcataaggga atgctgtgct acaaagctgt gcccaaatat   3000

gaaaacaaaa taggaaactt aaaaagcaat acccccttta gaaagttttt attttcttaa   3060

atgtcattga gttgctttga ttctattgga tttttggcat tttttatggg atcatcagtt   3120

ggttccaagt atgttagatc agctaacatc tgctactcca gtaacagcct cgtacaactg   3180

caggtaggtt ttctccagac caattagttt taatagagca aactaacaac agactgtagt   3240

agcatggtta tggcaaccag aatcttcaga aaggttagga cattactttt taagctgtca   3300

gtggtatcaa ataacttacc tagttggagg cagataaagg atcccttacg ttttttccta   3360

taaggcctaa attgaaattg ttaaccaagg aaacagggtc agccttgaaa aatcaaggaa   3420

ttcattgtac ctaataactg aagtaaaaat aactagttgt tcaacttttc ctaaactcaa   3480

atctattttt ataaacaaat gtaaataatg tttatattag agttgaactg gttttcattt   3540

ttataactgg tagactagac cttccttaaa cttttagaaa taaaatgaag gcttcactgg   3600

atttgtgagg ataaaataca ttttctttaa ttgtcctaga gcaaagtaca ttagtcacca   3660

tgtgtttttt gtgccaatgt aacttgtaat ttaccaaaga aaaatacata cattgcttgg   3720

tcttgcagaa aagttccctt gaaagaacct ttccaataaa taaaacgtcc caaattagca   3780

gtaccttggg ctgtttttca tgagtaagaa gattcaccat cccatgtgat ctgtgtggaa   3840

aaagaccatg tcctcttggt ggaagacatg agagagctga actgaagtgg aggaggtggt   3900

gcaagaggga ccttcctgct caaggcccgc ccaggcagcg gaatagagtg cagtgcttgg   3960

ctgcagaaac cctttgtccc tcacctatat atacacggac agtcaagttt gttgctctaa   4020

cgtaaggcac agcgttaatc ctgtatggcc aggaaactga gtagactcct gtgtaaccct   4080

gtttggaact ttgccttctt aaaatgattt ttc                                4113


<210>  934
<211>  642
<212>  PRT
<213>  Homosapiens

<400>  934

Met Pro Cys Gly Glu Asp Trp Leu Ser His Pro Leu Gly Ile Val Gln 
1               5                   10                  15      


Gly Phe Phe Ala Gln Asn Gly Val Asn Pro Asp Trp Glu Lys Lys Val 
            20                  25                  30          


Ile Glu Tyr Phe Lys Glu Lys Leu Lys Glu Asn Asn Ala Pro Lys Trp 
        35                  40                  45              


Val Pro Ser Leu Asn Glu Val Pro Leu His Tyr Leu Lys Pro Asn Ser 
    50                  55                  60                  


Phe Val Lys Phe Arg Cys Met Ile Gln Asp Met Phe Asp Pro Glu Phe 
65                  70                  75                  80  


Tyr Met Gly Val Tyr Glu Thr Val Asn Gln Asn Thr Lys Ala His Val 
                85                  90                  95      


Leu His Phe Gly Lys Tyr Arg Asp Val Ala Glu Cys Gly Pro Gln Gln 
            100                 105                 110         


Glu Leu Asp Leu Asn Ser Pro Arg Asn Thr Thr Leu Glu Arg Gln Thr 
        115                 120                 125             


Phe Tyr Cys Val Pro Val Pro Gly Glu Ser Thr Trp Val Lys Glu Ala 
    130                 135                 140                 


Tyr Val Asn Ala Asn Gln Ala Arg Val Ser Pro Ser Thr Ser Tyr Thr 
145                 150                 155                 160 


Pro Ser Arg His Lys Arg Ser Tyr Glu Asp Asp Asp Asp Met Asp Leu 
                165                 170                 175     


Gln Pro Asn Lys Gln Lys Asp Gln His Ala Gly Ala Arg Gln Ala Gly 
            180                 185                 190         


Ser Val Gly Gly Leu Gln Trp Cys Gly Glu Pro Lys Arg Leu Glu Thr 
        195                 200                 205             


Glu Ala Ser Thr Gly Gln Gln Leu Asn Ser Leu Asn Leu Ser Ser Pro 
    210                 215                 220                 


Phe Asp Leu Asn Phe Pro Leu Pro Gly Glu Lys Gly Pro Ala Cys Leu 
225                 230                 235                 240 


Val Lys Val Tyr Glu Asp Trp Asp Cys Phe Lys Val Asn Asp Ile Leu 
                245                 250                 255     


Glu Leu Tyr Gly Ile Leu Ser Val Asp Pro Val Leu Ser Ile Leu Asn 
            260                 265                 270         


Asn Asp Glu Arg Asp Ala Ser Ala Leu Leu Asp Pro Met Glu Cys Thr 
        275                 280                 285             


Asp Thr Ala Glu Glu Gln Arg Val His Ser Pro Pro Ala Ser Leu Val 
    290                 295                 300                 


Pro Arg Ile His Val Ile Leu Ala Gln Lys Leu Gln His Ile Asn Pro 
305                 310                 315                 320 


Leu Leu Pro Ala Cys Leu Asn Lys Glu Glu Ser Lys Thr Cys Lys Phe 
                325                 330                 335     


Val Ser Ser Phe Met Ser Glu Leu Ser Pro Val Arg Ala Glu Leu Leu 
            340                 345                 350         


Gly Phe Leu Thr His Ala Leu Leu Gly Asp Ser Leu Ala Ala Glu Tyr 
        355                 360                 365             


Leu Ile Leu His Leu Ile Ser Thr Val Tyr Thr Arg Arg Asp Val Leu 
    370                 375                 380                 


Pro Leu Gly Lys Phe Thr Val Asn Leu Ser Gly Cys Pro Arg Asn Ser 
385                 390                 395                 400 


Thr Phe Thr Glu His Leu Tyr Arg Ile Ile Gln His Leu Val Pro Ala 
                405                 410                 415     


Ser Phe Arg Leu Gln Met Thr Ile Glu Asn Met Asn His Leu Lys Phe 
            420                 425                 430         


Ile Pro His Lys Asp Tyr Thr Ala Asn Arg Leu Val Ser Gly Leu Leu 
        435                 440                 445             


Gln Leu Pro Ser Asn Thr Ser Leu Val Ile Asp Glu Thr Leu Leu Glu 
    450                 455                 460                 


Gln Gly Gln Leu Asp Thr Pro Gly Val His Asn Val Thr Ala Leu Ser 
465                 470                 475                 480 


Asn Leu Ile Thr Trp Gln Lys Val Asp Tyr Asp Phe Ser Tyr His Gln 
                485                 490                 495     


Met Glu Phe Pro Cys Asn Ile Asn Val Phe Ile Thr Ser Glu Gly Arg 
            500                 505                 510         


Ser Leu Leu Pro Ala Asp Cys Gln Ile His Leu Gln Pro Gln Leu Ile 
        515                 520                 525             


Pro Pro Asn Met Glu Glu Tyr Met Asn Ser Leu Leu Ser Ala Val Leu 
    530                 535                 540                 


Pro Ser Val Leu Asn Lys Phe Arg Ile Tyr Leu Thr Leu Leu Arg Phe 
545                 550                 555                 560 


Leu Glu Tyr Ser Ile Ser Asp Glu Ile Thr Lys Ala Val Glu Asp Asp 
                565                 570                 575     


Phe Val Glu Met Arg Lys Asn Asp Pro Gln Ser Ile Thr Ala Asp Asp 
            580                 585                 590         


Leu His Gln Leu Leu Val Val Ala Arg Cys Leu Ser Leu Ser Ala Gly 
        595                 600                 605             


Gln Thr Thr Leu Ser Arg Glu Arg Trp Leu Arg Ala Lys Gln Leu Glu 
    610                 615                 620                 


Ser Leu Arg Arg Thr Arg Leu Gln Gln Gln Lys Cys Val Asn Gly Asn 
625                 630                 635                 640 


Glu Leu 
        


<210>  935
<211>  4243
<212>  DNA
<213>  Homosapiens

<400>  935
gcgtgatcgg tttccggtca gtggtgtggt accgggtacc cggagacgtg tatcggacgg     60

tgggccgcag ccatggccga gagaaaacct aacggtggca gcggcggcgc ctccacttcc    120

tcatcgggca ctaacttact tttctcctcc tcggccacgg agttcagctt caatgtgccc    180

ttcatcccag tcacccaggc ctccgcttct ccggcctccc tgctcttacc gggagaggat    240

tccacagatg ttggtgagga ggacagcttc cttggtcaga cttctattca cacatctgcc    300

ccacagacat ttagttactt ctctcaggta tcaagcagca gtgatccttt tgggaatatt    360

ggacagtcac cattaacaac tgcagcaacc tcagttggac aatcaggatt ccccaagccc    420

ctgactgctc tcccttttac aactggatcc caagatgtct cgaatgcatt ttcaccatcc    480

atttcgaagg ctcaacctgg tgctccacct tcctcactga tgggaataaa ttcttatctg    540

ccttctcagc caagtagtct ccctccttca tattttggga accaacccca aggaattccc    600

caaccaggat acaatccata tcgccatacc cctggcagca gcagggctaa tccttacatt    660

gcaccacccc agctgcagca gtgccaaaca ccaggccctc ctgctcatcc tccaccttct    720

ggaccccctg ttcagatgta ccagatgcct ccaggatctt tgccaccggt tccttcttca    780

gtgcagtcac cggcacagca gcaggtacct gccagacctg gggctccctc tgttcaagtg    840

ccatctcctt ttctacttca aaaccaatat gagcctgttc agccccactg gttttactgc    900

aaggaggtag aatacaaaca actgtggatg ccttttagtg tgttcgactc tttgaatctt    960

gaagaaatct ataattcagt tcagccagat ccggagagcg tggttcttgg cacggatgga   1020

gggcgctacg atgtttacct ctatgaccga ataaggaagg ctgcctactg ggaagaggag   1080

ccagccgaag tgagacgctg tacttggttt tacaaggggg acacagatag tcgatttatt   1140

ccctatactg aggagttcag tgaaaaacta gaggctgaat ataaaaaagc tgtaaccact   1200

aatcagtggc accgaagatt agagtttcca agtggagaga caattgttat gcacaatcca   1260

aaggttattg ttcagttcca gccctcctca gtgccagatg aatggggcac cacgcaagat   1320

ggacagacaa ggcccagggt tgtaaagcgt ggaattgatg ataaccttga tgaaattccc   1380

gacggggaga tgcctcaagt tgaccatttg gtgtttgtgg tgcatggcat tggacctgtg   1440

tgtgacttac gctttaggag cattattgag tgtgtggatg attttagggt ggtttctctc   1500

aaattgctgc ggacacattt caagaaatct ttagatgacg ggaaagtaag cagagtggag   1560

ttccttccag ttcattggca tagttctttg ggtggggacg ccacaggtgt ggacaggaat   1620

attaagaaaa tcactttgcc aagtattggt cgatttcgtc actttaccaa tgaaactttg   1680

ctagatattt tattttataa cagccccacc tactgtcaga caattgtgga aaaagtagga   1740

atggagataa accatctgca tgcactcttt atgagtcgga acccagactt caaaggaggt   1800

gtctctgttg ctggtcacag tttaggttct ttaatattgt ttgacatcct gtctaatcaa   1860

aaagatttga atttatcaaa gtgccctgga cctcttgctg ttgctaatgg agttgtgaag   1920

cagctacatt ttcaggaaaa gcagatgcct gaagagccaa agctgacttt ggatgagtcg   1980

tatgaccttg ttgttgaaaa taaagaagtc ctaactttgc aagaaactct ggaagcactt   2040

agcctctctg aatattttag cacttttgaa aaggaaaaga ttgatatgga gtccctgctt   2100

atgtgtacag ttgatgacct gaaggaaatg gggatacccc ttggacccag aaagaagata   2160

gctaactttg tagaacataa agcagccaaa ctgaaaaaag cagcgtcaga aaagaaggca   2220

gtggcggcca cttctacaaa aggacaagag caaagtgccc agaagactaa agacatggct   2280

tccctcccct cagaatccaa tgagccaaag aggaaacttc cagttggtgc ttgcgtgtct   2340

tctgtgtgtg tgaattatga atcttttgaa gttggcgccg gacaggtttc tgttgcttac   2400

aactcattag attttgaacc agagatattc tttgccttgg ggtctccaat tgctatgttt   2460

ctcactattc gaggagttga taggatagat gagaattaca gccttcctac ctgtaaaggg   2520

ttcttcaata tttatcatcc gcttgatcca gtggcatata gattagaacc tatgattgtt   2580

ccagatttgg acctaaaagc tgttctcatt ccacatcaca aaggcagaaa aagacttcat   2640

ttagaattga aagagagtct ctctcgtatg ggatctgatt tgaagcaggg ttttattagc   2700

tctctcaaaa gtgcttggca gacattaaat gagtttgccc gtgctcatac gtcttcaacc   2760

cagttgcaag aagaattgga gaaggtggcc aatcagatca aagaagaaga agaaaagcaa   2820

gtagttgaag cagaaaaggt tgttgaaagt ccagattttt ccaaggatga ggactactta   2880

ggaaaggttg gaatgttaaa tggaggccgc cgaattgact acgttctcca agaaaaacca   2940

atagagagtt ttaatgaata ccttttcgct cttcagagtc acttatgcta ttgggaatct   3000

gaagatactg ctctgttact acttaaagaa atttatcgaa caatgaacat tagtccagaa   3060

cagccccagc attgatcaaa cttcagtttt actgtacttt cttgtctgca cagaaagtcc   3120

cagtacaact tccattgctg agaaaatcct cagaggactt tcccacttcg ctcctgtgat   3180

ggatgacaga agagtgattc attaacaatt gctcagccac aattctcgga tatagggatt   3240

caaaagacag gacacagaac taacacagtg aaaaaaatca gtaccacatt tggacagtat   3300

aggtgagaaa acataattat aaaaatgatg ccatgaaaaa ttccacagat cagtttagtt   3360

gtatagttgt caaagttata tgtgatatca atgaagaaat atttgtagca tgtaaacggt   3420

tatttctgtt tcttaaaaag tattgttagt gggctattaa acttggattt ttctttttat   3480

taatgcagta tgttcttttt attcaagtat gaacttgttg agaaactata gtaatatgat   3540

ttttaagaga tttatgttct acttaaaatg tgaattgtac ttctgagctg ccttaatgca   3600

aggtcattta tatttgttaa gaggaaataa tcaagatcac tcatatccca actgaatctg   3660

aggttttata aatccctcaa acgattgctg agagcctgat tgtggaaaga agtgagatgc   3720

accttatttt caagaagtcc tgggaagcgc tctcctagca cgtccatttc caggaggaga   3780

agcaagcaga tgagaggttt tccattttgt catccaaggt agctgtgcac ttgccttgtt   3840

gctgaagttc caataatgtg aaaaccaaag tagaggtttt tttcttcttc tttttgtttt   3900

ctattaattt cacttatacc aaagtgtttg aaagtatgaa atgtgttgct tctgagttat   3960

ataaggctac ttcatgacaa gactgctttg taatatttca ctttgtttta ctacaaattc   4020

agatcacttt gttttactat aaattcagat tatccaaata ttttcctaat actatgtggg   4080

aatgctgatt ttcttttgtt acgtagtgga aacattttgc attgtttaca tagttctcat   4140

ggaacatgga aatttttgaa agtgatatat gatacacatt ttttgtgtat gtattctaat   4200

tagtgtgaat aaagcagtaa cattaatgca ttttttaagc agc                     4243


<210>  936
<211>  1000
<212>  PRT
<213>  Homosapiens

<400>  936

Met Ala Glu Arg Lys Pro Asn Gly Gly Ser Gly Gly Ala Ser Thr Ser 
1               5                   10                  15      


Ser Ser Gly Thr Asn Leu Leu Phe Ser Ser Ser Ala Thr Glu Phe Ser 
            20                  25                  30          


Phe Asn Val Pro Phe Ile Pro Val Thr Gln Ala Ser Ala Ser Pro Ala 
        35                  40                  45              


Ser Leu Leu Leu Pro Gly Glu Asp Ser Thr Asp Val Gly Glu Glu Asp 
    50                  55                  60                  


Ser Phe Leu Gly Gln Thr Ser Ile His Thr Ser Ala Pro Gln Thr Phe 
65                  70                  75                  80  


Ser Tyr Phe Ser Gln Val Ser Ser Ser Ser Asp Pro Phe Gly Asn Ile 
                85                  90                  95      


Gly Gln Ser Pro Leu Thr Thr Ala Ala Thr Ser Val Gly Gln Ser Gly 
            100                 105                 110         


Phe Pro Lys Pro Leu Thr Ala Leu Pro Phe Thr Thr Gly Ser Gln Asp 
        115                 120                 125             


Val Ser Asn Ala Phe Ser Pro Ser Ile Ser Lys Ala Gln Pro Gly Ala 
    130                 135                 140                 


Pro Pro Ser Ser Leu Met Gly Ile Asn Ser Tyr Leu Pro Ser Gln Pro 
145                 150                 155                 160 


Ser Ser Leu Pro Pro Ser Tyr Phe Gly Asn Gln Pro Gln Gly Ile Pro 
                165                 170                 175     


Gln Pro Gly Tyr Asn Pro Tyr Arg His Thr Pro Gly Ser Ser Arg Ala 
            180                 185                 190         


Asn Pro Tyr Ile Ala Pro Pro Gln Leu Gln Gln Cys Gln Thr Pro Gly 
        195                 200                 205             


Pro Pro Ala His Pro Pro Pro Ser Gly Pro Pro Val Gln Met Tyr Gln 
    210                 215                 220                 


Met Pro Pro Gly Ser Leu Pro Pro Val Pro Ser Ser Val Gln Ser Pro 
225                 230                 235                 240 


Ala Gln Gln Gln Val Pro Ala Arg Pro Gly Ala Pro Ser Val Gln Val 
                245                 250                 255     


Pro Ser Pro Phe Leu Leu Gln Asn Gln Tyr Glu Pro Val Gln Pro His 
            260                 265                 270         


Trp Phe Tyr Cys Lys Glu Val Glu Tyr Lys Gln Leu Trp Met Pro Phe 
        275                 280                 285             


Ser Val Phe Asp Ser Leu Asn Leu Glu Glu Ile Tyr Asn Ser Val Gln 
    290                 295                 300                 


Pro Asp Pro Glu Ser Val Val Leu Gly Thr Asp Gly Gly Arg Tyr Asp 
305                 310                 315                 320 


Val Tyr Leu Tyr Asp Arg Ile Arg Lys Ala Ala Tyr Trp Glu Glu Glu 
                325                 330                 335     


Pro Ala Glu Val Arg Arg Cys Thr Trp Phe Tyr Lys Gly Asp Thr Asp 
            340                 345                 350         


Ser Arg Phe Ile Pro Tyr Thr Glu Glu Phe Ser Glu Lys Leu Glu Ala 
        355                 360                 365             


Glu Tyr Lys Lys Ala Val Thr Thr Asn Gln Trp His Arg Arg Leu Glu 
    370                 375                 380                 


Phe Pro Ser Gly Glu Thr Ile Val Met His Asn Pro Lys Val Ile Val 
385                 390                 395                 400 


Gln Phe Gln Pro Ser Ser Val Pro Asp Glu Trp Gly Thr Thr Gln Asp 
                405                 410                 415     


Gly Gln Thr Arg Pro Arg Val Val Lys Arg Gly Ile Asp Asp Asn Leu 
            420                 425                 430         


Asp Glu Ile Pro Asp Gly Glu Met Pro Gln Val Asp His Leu Val Phe 
        435                 440                 445             


Val Val His Gly Ile Gly Pro Val Cys Asp Leu Arg Phe Arg Ser Ile 
    450                 455                 460                 


Ile Glu Cys Val Asp Asp Phe Arg Val Val Ser Leu Lys Leu Leu Arg 
465                 470                 475                 480 


Thr His Phe Lys Lys Ser Leu Asp Asp Gly Lys Val Ser Arg Val Glu 
                485                 490                 495     


Phe Leu Pro Val His Trp His Ser Ser Leu Gly Gly Asp Ala Thr Gly 
            500                 505                 510         


Val Asp Arg Asn Ile Lys Lys Ile Thr Leu Pro Ser Ile Gly Arg Phe 
        515                 520                 525             


Arg His Phe Thr Asn Glu Thr Leu Leu Asp Ile Leu Phe Tyr Asn Ser 
    530                 535                 540                 


Pro Thr Tyr Cys Gln Thr Ile Val Glu Lys Val Gly Met Glu Ile Asn 
545                 550                 555                 560 


His Leu His Ala Leu Phe Met Ser Arg Asn Pro Asp Phe Lys Gly Gly 
                565                 570                 575     


Val Ser Val Ala Gly His Ser Leu Gly Ser Leu Ile Leu Phe Asp Ile 
            580                 585                 590         


Leu Ser Asn Gln Lys Asp Leu Asn Leu Ser Lys Cys Pro Gly Pro Leu 
        595                 600                 605             


Ala Val Ala Asn Gly Val Val Lys Gln Leu His Phe Gln Glu Lys Gln 
    610                 615                 620                 


Met Pro Glu Glu Pro Lys Leu Thr Leu Asp Glu Ser Tyr Asp Leu Val 
625                 630                 635                 640 


Val Glu Asn Lys Glu Val Leu Thr Leu Gln Glu Thr Leu Glu Ala Leu 
                645                 650                 655     


Ser Leu Ser Glu Tyr Phe Ser Thr Phe Glu Lys Glu Lys Ile Asp Met 
            660                 665                 670         


Glu Ser Leu Leu Met Cys Thr Val Asp Asp Leu Lys Glu Met Gly Ile 
        675                 680                 685             


Pro Leu Gly Pro Arg Lys Lys Ile Ala Asn Phe Val Glu His Lys Ala 
    690                 695                 700                 


Ala Lys Leu Lys Lys Ala Ala Ser Glu Lys Lys Ala Val Ala Ala Thr 
705                 710                 715                 720 


Ser Thr Lys Gly Gln Glu Gln Ser Ala Gln Lys Thr Lys Asp Met Ala 
                725                 730                 735     


Ser Leu Pro Ser Glu Ser Asn Glu Pro Lys Arg Lys Leu Pro Val Gly 
            740                 745                 750         


Ala Cys Val Ser Ser Val Cys Val Asn Tyr Glu Ser Phe Glu Val Gly 
        755                 760                 765             


Ala Gly Gln Val Ser Val Ala Tyr Asn Ser Leu Asp Phe Glu Pro Glu 
    770                 775                 780                 


Ile Phe Phe Ala Leu Gly Ser Pro Ile Ala Met Phe Leu Thr Ile Arg 
785                 790                 795                 800 


Gly Val Asp Arg Ile Asp Glu Asn Tyr Ser Leu Pro Thr Cys Lys Gly 
                805                 810                 815     


Phe Phe Asn Ile Tyr His Pro Leu Asp Pro Val Ala Tyr Arg Leu Glu 
            820                 825                 830         


Pro Met Ile Val Pro Asp Leu Asp Leu Lys Ala Val Leu Ile Pro His 
        835                 840                 845             


His Lys Gly Arg Lys Arg Leu His Leu Glu Leu Lys Glu Ser Leu Ser 
    850                 855                 860                 


Arg Met Gly Ser Asp Leu Lys Gln Gly Phe Ile Ser Ser Leu Lys Ser 
865                 870                 875                 880 


Ala Trp Gln Thr Leu Asn Glu Phe Ala Arg Ala His Thr Ser Ser Thr 
                885                 890                 895     


Gln Leu Gln Glu Glu Leu Glu Lys Val Ala Asn Gln Ile Lys Glu Glu 
            900                 905                 910         


Glu Glu Lys Gln Val Val Glu Ala Glu Lys Val Val Glu Ser Pro Asp 
        915                 920                 925             


Phe Ser Lys Asp Glu Asp Tyr Leu Gly Lys Val Gly Met Leu Asn Gly 
    930                 935                 940                 


Gly Arg Arg Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu Ser Phe 
945                 950                 955                 960 


Asn Glu Tyr Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp Glu Ser 
                965                 970                 975     


Glu Asp Thr Ala Leu Leu Leu Leu Lys Glu Ile Tyr Arg Thr Met Asn 
            980                 985                 990         


Ile Ser Pro Glu Gln Pro Gln His  
        995                 1000 


<210>  937
<211>  1116
<212>  DNA
<213>  Homosapiens

<400>  937
atggagaatg caggttctga tcttcaacag agctgcagcc ccagcaccga gctcctcgag     60

ggccctctac gaaggcagcc gcgttcctcc agagggctgt gtactctcag agacactgtg    120

ggcgctggcg ggctagagcg aggagccagg gtcacactgc accttccgaa ttctctccct    180

cttcacttcg gtcactccgg agagggccag gaagagccgc gagccgcgca ccggggccag    240

acggggatcc ttgtccctcc tgtgccacct gcgggccgtt ccatgcgcag cgacccaggg    300

tctgcaaatg gggtggtgac aagaggcgca gacagctctt ttgcgcttct tggggggctg    360

cggagagttg aagaaaccaa ggcagcggta gaggaagagg acgtggctgt ggcagcggaa    420

gagggggtca taggtcataa cgtctctcaa gatgactctt caaagaattt tccagtgact    480

gcccccattg ttcctcaatg ctcagggaag ggcccagtga aaaagacagt gtccagcaaa    540

gccacagaaa ccatccctgc tgtggaacag gagttgccgc agccccaggc tgacagaggg    600

tctggaacag aatctgacag tgatgaatca gtaccagagt ttgaggaaca ggattccaca    660

cagacaacca cacaacaagc ccagctggca gcagcagctg aaattaataa agaaccagtc    720

agcaaagcaa aacagagtca gagtgaaaag aaagcacaga aggctatgtc caaactgggt    780

cttcaacagg ttacaggggt tactagagtc actatctgga aatctaagaa tatcctcttt    840

gtcatcacaa aagcagatgt ctacaagcgc cctgctttgg atacctacat agttttgggg    900

ggaaccaaaa atgaagattt atctcagcaa gcacagctag cagctgctga gaaattcaaa    960

gttcaaggat ccttcagtga cactgtccac cttcaccctg ctcgtgactt ctgcgtcccc   1020

tgggcactga gccttggagc tctggacttc cccagtgaca gaccaggctc caggaactca   1080

gaccaggggc agcacttcag gcctccacgt tcttga                             1116


<210>  938
<211>  371
<212>  PRT
<213>  Homosapiens

<400>  938

Met Glu Asn Ala Gly Ser Asp Leu Gln Gln Ser Cys Ser Pro Ser Thr 
1               5                   10                  15      


Glu Leu Leu Glu Gly Pro Leu Arg Arg Gln Pro Arg Ser Ser Arg Gly 
            20                  25                  30          


Leu Cys Thr Leu Arg Asp Thr Val Gly Ala Gly Gly Leu Glu Arg Gly 
        35                  40                  45              


Ala Arg Val Thr Leu His Leu Pro Asn Ser Leu Pro Leu His Phe Gly 
    50                  55                  60                  


His Ser Gly Glu Gly Gln Glu Glu Pro Arg Ala Ala His Arg Gly Gln 
65                  70                  75                  80  


Thr Gly Ile Leu Val Pro Pro Val Pro Pro Ala Gly Arg Ser Met Arg 
                85                  90                  95      


Ser Asp Pro Gly Ser Ala Asn Gly Val Val Thr Arg Gly Ala Asp Ser 
            100                 105                 110         


Ser Phe Ala Leu Leu Gly Gly Leu Arg Arg Val Glu Glu Thr Lys Ala 
        115                 120                 125             


Ala Val Glu Glu Glu Asp Val Ala Val Ala Ala Glu Glu Gly Val Ile 
    130                 135                 140                 


Gly His Asn Val Ser Gln Asp Asp Ser Ser Lys Asn Phe Pro Val Thr 
145                 150                 155                 160 


Ala Pro Ile Val Pro Gln Cys Ser Gly Lys Gly Pro Val Lys Lys Thr 
                165                 170                 175     


Val Ser Ser Lys Ala Thr Glu Thr Ile Pro Ala Val Glu Gln Glu Leu 
            180                 185                 190         


Pro Gln Pro Gln Ala Asp Arg Gly Ser Gly Thr Glu Ser Asp Ser Asp 
        195                 200                 205             


Glu Ser Val Pro Glu Phe Glu Glu Gln Asp Ser Thr Gln Thr Thr Thr 
    210                 215                 220                 


Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asn Lys Glu Pro Val 
225                 230                 235                 240 


Ser Lys Ala Lys Gln Ser Gln Ser Glu Lys Lys Ala Gln Lys Ala Met 
                245                 250                 255     


Ser Lys Leu Gly Leu Gln Gln Val Thr Gly Val Thr Arg Val Thr Ile 
            260                 265                 270         


Trp Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Ala Asp Val Tyr 
        275                 280                 285             


Lys Arg Pro Ala Leu Asp Thr Tyr Ile Val Leu Gly Gly Thr Lys Asn 
    290                 295                 300                 


Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 
305                 310                 315                 320 


Val Gln Gly Ser Phe Ser Asp Thr Val His Leu His Pro Ala Arg Asp 
                325                 330                 335     


Phe Cys Val Pro Trp Ala Leu Ser Leu Gly Ala Leu Asp Phe Pro Ser 
            340                 345                 350         


Asp Arg Pro Gly Ser Arg Asn Ser Asp Gln Gly Gln His Phe Arg Pro 
        355                 360                 365             


Pro Arg Ser 
    370     


<210>  939
<211>  1485
<212>  DNA
<213>  Homosapiens

<400>  939
ggacctgcag cctcccaggt ggctgggaag aactctccaa caataaatac atttgataag     60

aaagatggct ttaaaagtgc tactagaaca agagaaaacg tttttcactc ttttagtatt    120

actaggctat ttgtcatgta aagtgacttg tgaatcagga gactgtagac agcaagaatt    180

cagggatcgg tctggaaact gtgttccctg caaccagtgt gggccaggca tggagttgtc    240

taaggaatgt ggcttcggct atggggagga tgcacagtgt gtgacgtgcc ggctgcacag    300

gttcaaggag gactggggct tccagaaatg caagccctgt ctggactgcg cagtggtgaa    360

ccgctttcag aaggcaaatt gttcagccac cagtgatgcc atctgcgggg actgcttgcc    420

aggattttat aggaagacga aacttgtcgg ctttcaagac atggagtgtg tgccttgtgg    480

agaccctcct cctccttacg aaccgcactg tgccagcaag gtcaacctcg tgaagatcgc    540

gtccacggcc tccagcccac gggacacggc gctggctgcc gttatctgca gcgctctggc    600

caccgtcctg ctggccctgc tcatcctctg tgtcatctat tgtaagagac agtttatgga    660

gaagaaaccc agctggtctc tgcggtcaca ggacattcag tacaacggct ctgagctgtc    720

gtgttttgac agacctcagc tccacgaata tgcccacaga gcctgctgcc agtgccgccg    780

tgactcagtg cagacctgcg ggccggtgcg cttgctccca tccatgtgct gtgaggaggc    840

ctgcagcccc aacccggcga ctcttggttg tggggtgcat tctgcagcca gtcttcaggc    900

aagaaacgca ggcccagccg gggagatggt gccgactttc ttcggatccc tcacgcagtc    960

catctgtggc gagttttcag atgcctggcc tctgatgcag aatcccatgg gtggtgacaa   1020

catctctttt tgtgactctt atcctgaact cactggagaa gacattcatt ctctcaatcc   1080

agaacttgaa agctcaacgt ctttggattc aaatagcagt caagatttgg ttggtggggc   1140

tgttccagtc cagtctcatt ctgaaaactt tacagcagct actgatttat ctagatataa   1200

caacacactg gtagaatcag catcaactca ggatgcacta actatgagaa gccagctaga   1260

tcaggagagt ggtgctgtca tccacccagc cactcagacg tccctccagg taaggcagcg   1320

actgggttcc ctgtgaacac agcactgact tacagtagat cagaactctg ttcccagcat   1380

aagatttggg ggaacctgat gagttttttt tttgcatctt taataatttc ttgtatgttg   1440

tagagtatgt tttaaaataa atttcaagta tttttttaaa aaact                   1485


<210>  940
<211>  423
<212>  PRT
<213>  Homosapiens

<400>  940

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Val 
                405                 410                 415     


Arg Gln Arg Leu Gly Ser Leu 
            420             


<210>  941
<211>  4283
<212>  DNA
<213>  Homosapiens

<400>  941
gggagggtaa ctacctgctg aaagtgaact ttctttgata tccatgcata tatataaact     60

cagccctgcc tttgatgttc agcaactgat tcactgatca gattacaggc atttcatctc    120

cctgctcgtc tgcctttgat ctgcatggtt aattttattt tcctggattt gaagtttcgt    180

ctgggcttgt gctgacatac atttttggga aggtagaagc atttggcaca gaagtgctgc    240

caggagaaac taagttgctg aacggaactc tccaacaata aatacatttg ataagaaaga    300

tggctttaaa agtgctacta gaacaagaga aaacgttttt cactctttta gtattactag    360

gctatttgtc atgtaaagtg acttgtgaat caggagactg tagacagcaa gaattcaggg    420

atcggtctgg aaactgtgtt ccctgcaacc agtgtgggcc aggcatggag ttgtctaagg    480

aatgtggctt cggctatggg gaggatgcac agtgtgtgac gtgccggctg cacaggttca    540

aggaggactg gggcttccag aaatgcaagc cctgtctgga ctgcgcagtg gtgaaccgct    600

ttcagaaggc aaattgttca gccaccagtg atgccatctg cggggactgc ttgccaggat    660

tttataggaa gacgaaactt gtcggctttc aagacatgga gtgtgtgcct tgtggagacc    720

ctcctcctcc ttacgaaccg cactgtgcca gcaaggtcaa cctcgtgaag atcgcgtcca    780

cggcctccag cccacgggac acggcgctgg ctgccgttat ctgcagcgct ctggccaccg    840

tcctgctggc cctgctcatc ctctgtgtca tctattgtaa gagacagttt atggagaaga    900

aacccagctg gtctctgcgg tcacaggaca ttcagtacaa cggctctgag ctgtcgtgtt    960

ttgacagacc tcagctccac gaatatgccc acagagcctg ctgccagtgc cgccgtgact   1020

cagtgcagac ctgcgggccg gtgcgcttgc tcccatccat gtgctgtgag gaggcctgca   1080

gccccaaccc ggcgactctt ggttgtgggg tgcattctgc agccagtctt caggcaagaa   1140

acgcaggccc agccggggag atggtgccga ctttcttcgg atccctcacg cagtccatct   1200

gtggcgagtt ttcagatgcc tggcctctga tgcagaatcc catgggtggt gacaacatct   1260

ctttttgtga ctcttatcct gaactcactg gagaagacat tcattctctc aatccagaac   1320

ttgaaagctc aacgtctttg gattcaaata gcagtcaaga tttggttggt ggggctgttc   1380

cagtccagtc tcattctgaa aactttacag cagctactga tttatctaga tataacaaca   1440

cactggtaga atcagcatca actcaggatg cactaactat gagaagccag ctagatcagg   1500

agagtggtgc tgtcatccac ccagccactc agacgtccct ccaggaagct taaagaacct   1560

gcttctttct gcagtagaag cgtgtgctgg aacccaaaga gtactccttt gttaggctta   1620

tggactgagc agtctggacc ttgcatggct tctggggcaa aaataaatct gaaccaaact   1680

gacggcattt gaagcctttc agccagttgc ttctgagcca gaccagctgt aagctgaaac   1740

ctcaatgaat aacaagaaaa gactccaggc cgactcatga tactctgcat ctttcctaca   1800

tgagaagctt ctctgccaca aaagtgactt caaagacgga tgggttgagc tggcagccta   1860

tgagattgtg gacatataac aagaaacaga aatgccctca tgcttatttt catggtgatt   1920

gtggttttac aagactgaag acccagagta tactttttct ttccagaaat aatttcatac   1980

cgcctatgaa atatcagata aattacctta gcttttatgt agaatgggtt caaaagtgag   2040

tgtttctatt tgagaaggac actttttcat catctaaact gattcgcata ggtggttaga   2100

atggccctca tattgcctgc ctaaatcttg ggtttattag atgaagttta ctgaatcaga   2160

ggaatcagac agaggaggat agctctttcc agaatccaca cttctgacct cagcctcggt   2220

ctcatgaaca cccgctgatc tcaggagaac acctgggcta gggaatgtgg tcgagaaagg   2280

gcagcccatt gcccagaatt aacacatatt gtagagactt gtatgcaaag gttggcatat   2340

ttatatgaaa attagttgct atagaaacat ttgttgcatc tgtccctctg cctgagctta   2400

gaaggttata gaaaaagggt atttataaac ataaatgacc ttttacttgc attgtatctt   2460

atactaaagg ctttagaaat tacaacatat caggttcccc tactactgaa gtagccttcc   2520

gtgagaacac accacatgtt aggactagaa gaaaatgcac aatttgtagg ggtttggatg   2580

aagcagctgt aactgcccta gtgtagtttg accaggacat tgtcgtgctc cttccaattg   2640

tgtaagatta gttagcacat catctcctac tttagccatc cggtgttgga tttaagagga   2700

cggtgcttct ttctattaaa gtgctccatc ccctaccatc tacacattag cattgtctct   2760

agagctaaga cagaaattaa ccccgttcag tcacaaagca gggaatggtt catttactct   2820

taatctttat gccctggaga agacctactt gaacagggca tattttttag acttctgaac   2880

atcagtatgt tcgagggtac tatgatattt tggtttggaa ttgccctgcc caagtcactg   2940

tcttttaact tttaaactga atattaaaat gtatctgtct ttcctagtat gtttttatct   3000

tctcatgtat tatccatggt tttctctgtt tgtgacagat tagtaaaatt taatgagccc   3060

tctttcttgt ggccgtttct ccatagtttt aggttttgat atgtgtttac tagcttgcct   3120

gtgtctggta catctcatga cctcaattcc ctcacctgaa ataggaaatg agaatgtttc   3180

attgtagccc caagcggtca tgtcaaccta gtgcctagtc ataattaatt gacttttcct   3240

gtattacttc tttttttaag tataaaccaa tgatcctttg gtagtcaaga actcttagga   3300

acattgcctt ttggacatgt aaaatattta ggatttgacc acacaatggc tatgaaaatg   3360

caagtagttt cctcgcgtga cctcaccatg attcacatac gtgccactgt ttgaaatctg   3420

gtctgtttgc atttctgtta tgacagagag atgatgtttg catttctgtt atgacagaga   3480

gatgatgaaa gtaggcaggg ctgtgttcct ttgtgtagcc tgtatatatt ttccatatgt   3540

agagccctga ttaacttcaa ggacaaacac tggctggaga aagccagact gatgggaatg   3600

agactttggc caaaaatccc aaaacatcat tttcaatcag tagagaagtg cttagggttg   3660

aaaattgatt tcatttgcta ctgaatttgg taaatcctgg gtaactttta tcaagatgaa   3720

gacattttac cctacctact ctagaaatat acaacaatgt tatattttac actccttgga   3780

aacatttgag gaaaaaaatg caatttgcac ttcactttgt tggaatatcc catagcactc   3840

aataaactca gctgctagag tgccgatgtc aggagggctg tgtcgggtaa tgcgtgtggc   3900

tgaatgggca taaccactgt ggcttcttgt gctgcagaag ctcgttgaca agactgagga   3960

ggatttcaag agcaaccaag taaagtcatg aattttctaa ttttgtgtat atggaatata   4020

tttttaaata gagatttttc tactttagat aatgtgttaa tattgctatt acctaggtta   4080

agcactattg tctgtgctag taagaaaaag aaaggaaaac catcattgct ttatagtagc   4140

ttatatcaat ttagatttca tcattactat tttgcatact ggaatttata aatgtgtaaa   4200

ttatcatttt cttagttttg taataccttt tttatttgtg aataaaatta tcacctggta   4260

ttcttaaaaa aaaaaaaaaa aaa                                           4283


<210>  942
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  942

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Glu 
                405                 410                 415     


Ala 
    


<210>  943
<211>  2392
<212>  DNA
<213>  Homosapiens

<400>  943
gcggagcgcg cgctcccagc gaaagcagca gggcagggat ctgcgttgga ggaagggact     60

gctctggtgc tagaatgctg tgcgtcggaa ggctgggcgg cttgggagcc agagcagcag    120

ctctgccgcc ccgccgggcg ggccggggaa gcctcgaagc cgggatccgg gcccgaaggg    180

tcagcaccag ctggtctccc gtgggcgccg ccttcaatgt caagccccag ggcagccgct    240

tggacctgtt cggcgagcgg gcgcgtcttt ttggagttcc tgagctgagt gccccagaag    300

gatttcatat tgcacaagaa aaagccttga gaaagacaga attgcttgtg gaccgtgcat    360

gttccacccc acctgggccc cagaccgtgc tgatcttcga tgagctctcg gattccttat    420

gcagagtggc cgacttggct gattttgtga aaatcgctca ccctgagcca gcattcagag    480

aagctgcgga agaagcttgt agaagtattg gcaccatggt agagaagttg aacacaaatg    540

tggatttata tcaaagtttg caaaaattac tagctgataa aaaacttgtg gattcccttg    600

atccagaaac aaggcgagtg gctgaactgt ttatgtttga ttttgaaatt agtggaatcc    660

atctagacaa acaaaagcgt aaaagagcag tggacctcaa tgttaaaatc ttggatttga    720

gtagtacatt tcttatggga accaattttc ccaacaagat tgagaagcat ctcttaccag    780

aacacattcg tcgtaacttt acatctgctg gggatcatat cataattgat ggtctccacg    840

cagaatcacc agatgacttg gtgcgagaag ctgcttataa aatttttctt tatcccaatg    900

ctggtcaatt gaaatgttta gaagaattgc tcagcagcag agatcttctg gcaaagttgg    960

tggggtattc cacgttttct cacagggctc tccaaggaac gatagctaaa aatccagaga   1020

ctgtcatgca gttccttgaa aaactatctg acaaactttc tgaaagaact ctgaaagatt   1080

ttgagatgat acgagggatg aaaatgaaac tgaatgctca aaattccgaa gtaatgccct   1140

gggacccccc ttactacagt ggtgtgattc gtgcagaaag gtataatatt gagcccagcc   1200

tatattgccc gtttttctct cttggagcat gcatggaagg cctgaatatt ttgcttaaca   1260

gactgttggg gatttcatta tatgcagagc agcctgcaaa aggagaggtg tggagcgaag   1320

atgtccgaaa actggctgtt gttcatgaat ctgaaggatt gttggggtac atttactgtg   1380

atttttttca gcgagcagac aaaccacatc aggattgcca tttcactatc cgtggaggca   1440

gactaaagga agatggagac tatcaactcc cacttgtagt tcttatgctg aatcttcccc   1500

gttcctcaag gagttctcca actttgctaa ctcctggcat gatggaaaat cttttccatg   1560

aaatgggaca tgccatgcat tcaatgctag gacgtactcg ttaccaacac gtcactggga   1620

ccaggtgccc tactgatttt gctgaggttc cttctattct gatggagtac tttgcaaatg   1680

attatcgagt agttaaccaa tttgccagac attatcagac tggacagcca ctgccaaaaa   1740

atatggtgtc tcgtctttgt gaatctaaaa aggtttgtgc tgcagctgat atgcaacttc   1800

aggtctttta tgccactctg gatcaaatct accatgggaa gcatcccctg aggaattcaa   1860

ccacagacat tctcaaggaa acacaagaga aattctatgg cctaccatat gttccaaata   1920

ctgcctggca gctgcgattc agccacctcg tggggtatgg tgctagatat tactcttacc   1980

tcatgtccag agcggtcgcc tccatggttt ggaaggagtg ttttctacag gatcctttca   2040

acagggctgc cggggagcgc tatcgcaggg agatgctggc ccacggtgga ggcagggagc   2100

ccatgctcat ggttgaaggt atgcttcaga agtgtccttc tgttgatgac ttcgtaagtg   2160

ccctcgtttc cgacttggat ctggacttcg aaactttcct catggattct gaataaaaga   2220

aacactctac acctctaatc aaggtcatgt agtaatgact ttgttataaa tgctacagct   2280

gtgagagctt gtttctgatt gtttcattgt tcgcttctgt aattctgaaa aactttaaac   2340

tggtagaact tggaataaat aatttgtttt aattaaaaaa aaaaaaaaaa aa           2392


<210>  944
<211>  713
<212>  PRT
<213>  Homosapiens

<400>  944

Met Leu Cys Val Gly Arg Leu Gly Gly Leu Gly Ala Arg Ala Ala Ala 
1               5                   10                  15      


Leu Pro Pro Arg Arg Ala Gly Arg Gly Ser Leu Glu Ala Gly Ile Arg 
            20                  25                  30          


Ala Arg Arg Val Ser Thr Ser Trp Ser Pro Val Gly Ala Ala Phe Asn 
        35                  40                  45              


Val Lys Pro Gln Gly Ser Arg Leu Asp Leu Phe Gly Glu Arg Ala Arg 
    50                  55                  60                  


Leu Phe Gly Val Pro Glu Leu Ser Ala Pro Glu Gly Phe His Ile Ala 
65                  70                  75                  80  


Gln Glu Lys Ala Leu Arg Lys Thr Glu Leu Leu Val Asp Arg Ala Cys 
                85                  90                  95      


Ser Thr Pro Pro Gly Pro Gln Thr Val Leu Ile Phe Asp Glu Leu Ser 
            100                 105                 110         


Asp Ser Leu Cys Arg Val Ala Asp Leu Ala Asp Phe Val Lys Ile Ala 
        115                 120                 125             


His Pro Glu Pro Ala Phe Arg Glu Ala Ala Glu Glu Ala Cys Arg Ser 
    130                 135                 140                 


Ile Gly Thr Met Val Glu Lys Leu Asn Thr Asn Val Asp Leu Tyr Gln 
145                 150                 155                 160 


Ser Leu Gln Lys Leu Leu Ala Asp Lys Lys Leu Val Asp Ser Leu Asp 
                165                 170                 175     


Pro Glu Thr Arg Arg Val Ala Glu Leu Phe Met Phe Asp Phe Glu Ile 
            180                 185                 190         


Ser Gly Ile His Leu Asp Lys Gln Lys Arg Lys Arg Ala Val Asp Leu 
        195                 200                 205             


Asn Val Lys Ile Leu Asp Leu Ser Ser Thr Phe Leu Met Gly Thr Asn 
    210                 215                 220                 


Phe Pro Asn Lys Ile Glu Lys His Leu Leu Pro Glu His Ile Arg Arg 
225                 230                 235                 240 


Asn Phe Thr Ser Ala Gly Asp His Ile Ile Ile Asp Gly Leu His Ala 
                245                 250                 255     


Glu Ser Pro Asp Asp Leu Val Arg Glu Ala Ala Tyr Lys Ile Phe Leu 
            260                 265                 270         


Tyr Pro Asn Ala Gly Gln Leu Lys Cys Leu Glu Glu Leu Leu Ser Ser 
        275                 280                 285             


Arg Asp Leu Leu Ala Lys Leu Val Gly Tyr Ser Thr Phe Ser His Arg 
    290                 295                 300                 


Ala Leu Gln Gly Thr Ile Ala Lys Asn Pro Glu Thr Val Met Gln Phe 
305                 310                 315                 320 


Leu Glu Lys Leu Ser Asp Lys Leu Ser Glu Arg Thr Leu Lys Asp Phe 
                325                 330                 335     


Glu Met Ile Arg Gly Met Lys Met Lys Leu Asn Ala Gln Asn Ser Glu 
            340                 345                 350         


Val Met Pro Trp Asp Pro Pro Tyr Tyr Ser Gly Val Ile Arg Ala Glu 
        355                 360                 365             


Arg Tyr Asn Ile Glu Pro Ser Leu Tyr Cys Pro Phe Phe Ser Leu Gly 
    370                 375                 380                 


Ala Cys Met Glu Gly Leu Asn Ile Leu Leu Asn Arg Leu Leu Gly Ile 
385                 390                 395                 400 


Ser Leu Tyr Ala Glu Gln Pro Ala Lys Gly Glu Val Trp Ser Glu Asp 
                405                 410                 415     


Val Arg Lys Leu Ala Val Val His Glu Ser Glu Gly Leu Leu Gly Tyr 
            420                 425                 430         


Ile Tyr Cys Asp Phe Phe Gln Arg Ala Asp Lys Pro His Gln Asp Cys 
        435                 440                 445             


His Phe Thr Ile Arg Gly Gly Arg Leu Lys Glu Asp Gly Asp Tyr Gln 
    450                 455                 460                 


Leu Pro Leu Val Val Leu Met Leu Asn Leu Pro Arg Ser Ser Arg Ser 
465                 470                 475                 480 


Ser Pro Thr Leu Leu Thr Pro Gly Met Met Glu Asn Leu Phe His Glu 
                485                 490                 495     


Met Gly His Ala Met His Ser Met Leu Gly Arg Thr Arg Tyr Gln His 
            500                 505                 510         


Val Thr Gly Thr Arg Cys Pro Thr Asp Phe Ala Glu Val Pro Ser Ile 
        515                 520                 525             


Leu Met Glu Tyr Phe Ala Asn Asp Tyr Arg Val Val Asn Gln Phe Ala 
    530                 535                 540                 


Arg His Tyr Gln Thr Gly Gln Pro Leu Pro Lys Asn Met Val Ser Arg 
545                 550                 555                 560 


Leu Cys Glu Ser Lys Lys Val Cys Ala Ala Ala Asp Met Gln Leu Gln 
                565                 570                 575     


Val Phe Tyr Ala Thr Leu Asp Gln Ile Tyr His Gly Lys His Pro Leu 
            580                 585                 590         


Arg Asn Ser Thr Thr Asp Ile Leu Lys Glu Thr Gln Glu Lys Phe Tyr 
        595                 600                 605             


Gly Leu Pro Tyr Val Pro Asn Thr Ala Trp Gln Leu Arg Phe Ser His 
    610                 615                 620                 


Leu Val Gly Tyr Gly Ala Arg Tyr Tyr Ser Tyr Leu Met Ser Arg Ala 
625                 630                 635                 640 


Val Ala Ser Met Val Trp Lys Glu Cys Phe Leu Gln Asp Pro Phe Asn 
                645                 650                 655     


Arg Ala Ala Gly Glu Arg Tyr Arg Arg Glu Met Leu Ala His Gly Gly 
            660                 665                 670         


Gly Arg Glu Pro Met Leu Met Val Glu Gly Met Leu Gln Lys Cys Pro 
        675                 680                 685             


Ser Val Asp Asp Phe Val Ser Ala Leu Val Ser Asp Leu Asp Leu Asp 
    690                 695                 700                 


Phe Glu Thr Phe Leu Met Asp Ser Glu 
705                 710             


<210>  945
<211>  1002
<212>  DNA
<213>  Homosapiens

<400>  945
atgaggatct ggtggcttct gcttgccatt gaaatctgca cagggaacat aaactcacag     60

gacacctgca ggcaagggca ccctggaatc cctgggaacc ccggtcacaa tggtctgcct    120

ggaagagatg gacgagacgg agcgaagggt gacaaaggcg atgcaggaga accaggatgt    180

cctggcagcc cggggaagga tgggacgagt ggagagaagg gagaacgagg agcagatgga    240

aaagttgaag caaaaggcat caaaggtgat caaggctcaa gaggatcccc aggaaaacat    300

ggccccaagg ggcttgcagg gcccatggga gagaaaggcc tccgaggaga gactgggcct    360

caggggcaga aggggaataa gggtgacgtg ggtcccactg gtcctgaggg gccaaggggc    420

aacattgggc ctttgggccc aactggttta ccgggcccca tgggccctat tggaaagcct    480

ggtcccaagg gagaagctgg acccacgggg ccccagggtg agccaggagt ccggggaata    540

agaggctgga aaggagatcg aggagagaaa gggaaaatcg gtgagactct agtcttgcca    600

aaaagtgctt tcactgtggg gctcacggtg ctgagcaagt ttccttcttc agatgtgccc    660

attaaatttg ataagatcct gtataatgaa ttcaaccatt atgatacagc agtggggaaa    720

ttcacgtgcc acattgctgg ggtctattac ttcacctacc acatcactgt tttctccagg    780

aatgttcagg tgtctttggt caaaaacgga gtaaaaatac tgcacaccag agatgcttac    840

gtgagctctg aggaccaggc ctctggcagc attgtcctgc agctgaagct cggggatgag    900

atgtggctgc aggtgacagg aggagagagg ttcaatggct tgtttgctga tgaggacgat    960

gacacaactt tcacagggtt ccttctgttc agcagccagt ga                      1002


<210>  946
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  946

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Cys Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Val Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Arg Asp Ala Tyr Val Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Met Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Gln 
                325                 330             


<210>  947
<211>  5075
<212>  DNA
<213>  Homosapiens

<400>  947
aaattgtttg gaaaacaagc cttggagagg aagagcagtt gggcaggtgg ccttagaagc     60

agagacagac gtccctgttg ataccactgt tgatggagaa gcactcggct ctcctccatc    120

aggggaaacc aaacctgcca ccccacctgg gatgtggcct ccccagggaa agagtagaga    180

ggctggagct ctggcagaac aggcctggca agggggctgg aggccaaggc tggtgttggg    240

gctcagatca aagccatcat gctgcatgga gcccaatcag ctgccaacac tcttggtgac    300

acagagccct cacgcctctg gtggaagaag ccagggctgg atgaagctgt ggcgtgcagc    360

ttctgcacag tctccgtgga atctctccta ctctcccgtg agcctttgga ggccttgcag    420

gagctcagcc tttcagcaga aggactgggt tcaaccgccc ctgcaggagc agctccttgg    480

cctcccaggc accagtggtt gggggctgca tcctctgtga gcctcaggtc aagcccatac    540

agtgccctag actcctccct gctctgaccc tgggcccagg agaaaggccg agcacctggc    600

cctctggaga caaggacatg gccattcctc agaggtcctt cccctgacaa gctgggcccc    660

ctgttgtggg gcgcaccact ggacatggta ggggagtggt ggcggccttg cccgaaggca    720

ggctgcggga ggggcggggc tggctcacca cagttggttg attcaagtga ggcctggggt    780

cctgctctcc ttccagcttc catctcagga tggctctcag ccccccacat tgaagaccaa    840

gaaggtgagg ggcaaaccaa gggccctgcc tatggaagct tcctgtgatg ggctgcaggt    900

agcaggggct ggagagggct gtggttgggg ccacaccagg ctcccccaac ctgagcatcc    960

tggaaggtga cagctcaccc ttggcagtgg caacccccag gccagcagcc ccatctgagg   1020

acagttgtct tcagtgccat tggctgtggc agcacagatg gggggtgtga agacctgagg   1080

ccctgcgact gtagcaccta cagccactgg agccagctct gcacaactca gacctgggtg   1140

gcgaggacat agctttgcag gtgggcagcc acatcccagg gggagcctgc aggccagtgg   1200

cagggtgggg gcaggcagag cagggtctcc ccactgttgc cgctgggctc ctgcggcttg   1260

tggagaaaga tgggtgggcc cacacatatt gctgctccct gaatctgagc ctcggtttcc   1320

ctacctgtga aacgggtacc catggcagct cagaagtgtc tggcagtggg gctgctgggg   1380

cacagtcatg ggggacccga gtcctgctct ccatgtgctc gcttccctca gtggtccctg   1440

atgccagcag aactttctcc caaaaagaga agggcgttcc tgtgagttct tgtgtggggg   1500

gtgggtcaca gagcctctcc aagtgcaggg cagggtgaag ggaggctgag gggtggttga   1560

atggccctgg gaagagctct cttgggctcc tcgtgtctgg gtggcctggg gagcatgctt   1620

ttgggcaggc ggctggcagg gctggtggct gagccactgt ggctcaggat ccccagccca   1680

ggcctgaata gggtaggcag ggagagggga gggtgagtgc atggtgcagg acagtgtgtc   1740

tcctggacag aaacagccct ggtcactcac ggccatggca tagccatggc tacaggaaag   1800

tgctgctgtg tgttgcagcc cctggggccg gctcccaatg gacacccagc agcatctccc   1860

ccactgtgct gaggggagtt gtgccagtgg ggtgctggca gcagtcctgg gaactggggg   1920

aagagccttg gcaagcccat ccctcctcgg gcatcaggga tgggctcacg tgaccaattt   1980

ctcccatgga agatgtttgg ggtgtgccca gaaaatgggg agggccctgt ggggcaggat   2040

tgtattatta aatccagaaa gtctgggctt ccatttttag cacaaggcag gcagcccacg   2100

tgccccagcc cagtggccag cctgtgtggg agaggggagt gggggccaga gggagtgagg   2160

cttctgttac tgcagccagc cagggtggcc agtgtggact ggacagcgag cactgcacca   2220

ggggcactgg tactgacctt gggccatgca cctgatgcct gtgagagtga tctctaggaa   2280

ccactgcaca agggggcaga tgaggggacc ctgacatggg acagctgagg gttacgccaa   2340

cacggggggg aaagctgtgt ccaggctcca ccggactccg ccgaggacag agcactgccc   2400

tgactctagg gtgcggggtc actgagggtt aggacagtct ggagttggga gagggccatg   2460

ctgcagctgg ggcacatccc acctgcacct ctccagatct tggagatggg acccccaccc   2520

acatgctccc caggtgggtc ccatcctggg gggtgcagga gggagctcca tgtgcccctg   2580

ctgatctgcc catctgagcc tcaggggtcc tgggcactga gagctgggct gggctcagcg   2640

ggggtatgca ttgacattgg ggacagagag gggatgctga agcgggtgct gtctgggtgg   2700

ggcctgcctg atcgacccag caggtgcacc cagcagccgg aggtgcttct agcagagtga   2760

acgccctgtc cttaggggca tgtgagctga ggctgggggc ctggagctgc agggggagga   2820

attggggaga gcagaggtcc caaagatgtc ccaaggcccc aagaccctgg tgaaggaatg   2880

gaggagccag cattggtcag cgagagggga gtgggagttg gatggcctgg ctctgggctg   2940

gacacacggt ttgcagccac agctgagctg tgctgtggag cccagttccc acctgggcat   3000

gtcctgtcct ctgaggcttc cgggagccgg acggccaccg cggtgcaggc gcgcactcaa   3060

gggctttcga ggctcactct gtcggagagg tcagagactg agtgtcgctg ctgaaggctg   3120

tggtggaccg ggctggatcg cggattctag gttagatcgc agatttggga tcgcggattg   3180

gggattggat tggggatttg gggttggatc agggatgtgg gggctggata ggggatttga   3240

ggattggatc ggggatttgg ggttggatcc tggatttggg gccgggtcgg cggtgggggg   3300

cagtgaaaag gtgacagaga gcagcccctg ctcgggagcc ggtggttggg ggtctgagaa   3360

gtcaccacca ccaagaagtt cttcggcttc gggagccgcg ggggcgagat ggcccgggct   3420

ccatagacca cgtctgcacg gttccgggta ccgaatccgg gacgcggaac agcggaaaat   3480

ccaagggcgg ctgtcaagga ccggaggtgg agcgcggcct ggagcgcagg agccggagac   3540

ctggaggccc gggacaagca gcacagaact gctctacatt tggcctgtgc cagcggccat   3600

gtggaagtgg tcactctcct ggtgaacaga caatgccaaa ttgacatctg tgacaaagaa   3660

aagagtgtgc ctttgataca ggcacaggct gtgcattgcc aagaagaggc ttgtgccatt   3720

attctgctgg aacgtggcgc caatccaaac cttaaggatg tctacagcaa cactgctctc   3780

cagtatgctg tgtatagtga gagcacatca ctggcaaaaa aactgctttc ccatgatgca   3840

aatactgaag cactggacaa ggatctcact ctgtcactca ggctggaata aagtggcaca   3900

actgtggctc actgcagcct caaccccctg agctcaggtc atcctgctac ctcagcctct   3960

tcagttgctg agactatagg ctcccacctc cactcctagc ctcagacgga gtctcactct   4020

gtcgccaggc tggagtgcag cggcatgatc tcggctcgct gcaaacctct gtctcccgag   4080

ttcacgtgat tctcctacct cagcctcccg agtagctggg actacaggcg tacgccacaa   4140

cgccaggcta attttttttt atttttggta gagacggggg tttcaccatg ttggccagga   4200

tggtctcaat ctcttgacct cgtaatctgc ctaccttggc ctcccaaagt gctgtgatta   4260

caggcgtgag ccaccgtgcc cagcccgaca tagatggttt ttttagggtt acagcgactt   4320

cttgttgaag ttgtctcaca actacctgat aaagtatttt tgatactgat tttgtaaatc   4380

accttattat taaattttca ataatatcta actctaacat acacttggaa aaatatcacc   4440

tcatacacaa ttcaccttct tttcctcatg tgtacatatt cctatttatt actgaatcca   4500

gttaaggaca cagcaggtgt tatcttcctg ccaaatagat attctgttac tagacgacag   4560

ttttagccca ccattcagtc atctgctgat aattcggcga tgcttaacaa cctgctgaag   4620

tctcaagaaa gcagtggata tgtgagtgag gctggcagtg gtcaattcta cactgaggaa   4680

cgtttccctc tttttcctct ttttttatta ggagctcaaa tcaacctcag gggtcctcag   4740

ttattcactt gcctgtccaa atctttccaa tagattcctg tctcagaata aaagaaaaat   4800

tccaatggct tttaaggccc tgtaggtaac ctcctgacct cagctgctat gagtctctct   4860

cctacttatg gcatttctac tatatgtgaa tcccacctcc cctcatttgt ctgaaaaagg   4920

tcacagataa ctacacttat cattgctgga caaagctcta tccaaatgat ggtcagtgag   4980

ccttcaaata aaaattataa gcaaattata tgtaataata gtaaattatg tataccagtg   5040

ggaaaaataa atcaaatatg gttttggtaa aattc                              5075


<210>  948
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  948

Met Ser Gln Gly Pro Lys Thr Leu Val Lys Glu Trp Arg Ser Gln His 
1               5                   10                  15      


Trp Ser Ala Arg Gly Glu Trp Glu Leu Asp Gly Leu Ala Leu Gly Trp 
            20                  25                  30          


Thr His Gly Leu Gln Pro Gln Leu Ser Cys Ala Val Glu Pro Ser Ser 
        35                  40                  45              


His Leu Gly Met Ser Cys Pro Leu Arg Leu Pro Gly Ala Gly Arg Pro 
    50                  55                  60                  


Pro Arg Cys Arg Arg Ala Leu Lys Gly Phe Arg Gly Ser Leu Cys Arg 
65                  70                  75                  80  


Arg Gly Gln Arg Leu Ser Val Ala Ala Glu Gly Cys Gly Gly Pro Gly 
                85                  90                  95      


Trp Ile Ala Asp Ser Arg Leu Asp Arg Arg Phe Gly Ile Ala Asp Trp 
            100                 105                 110         


Gly Leu Asp Trp Gly Phe Gly Val Gly Ser Gly Met Trp Gly Leu Asp 
        115                 120                 125             


Arg Gly Phe Glu Asp Trp Ile Gly Asp Leu Gly Leu Asp Pro Gly Phe 
    130                 135                 140                 


Gly Ala Gly Ser Ala Val Gly Gly Ser Glu Lys Val Thr Glu Ser Ser 
145                 150                 155                 160 


Pro Cys Ser Gly Ala Gly Gly Trp Gly Ser Glu Lys Ser Pro Pro Pro 
                165                 170                 175     


Arg Ser Ser Ser Ala Ser Gly Ala Ala Gly Ala Arg Trp Pro Gly Leu 
            180                 185                 190         


His Arg Pro Arg Leu His Gly Ser Gly Tyr Arg Ile Arg Asp Ala Glu 
        195                 200                 205             


Gln Arg Lys Ile Gln Gly Arg Leu Ser Arg Thr Gly Gly Gly Ala Arg 
    210                 215                 220                 


Pro Gly Ala Gln Glu Pro Glu Thr Trp Arg Pro Gly Thr Ser Ser Thr 
225                 230                 235                 240 


Glu Leu Leu Tyr Ile Trp Pro Val Pro Ala Ala Met Trp Lys Trp Ser 
                245                 250                 255     


Leu Ser Trp 
            


<210>  949
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  949
ggtggcgcga gcttctgaaa ctaggcggca gaggcggagc cgctgtggca ctgctgcgcc     60

tctgctgcgc ctcgggtgtc ttttgcggcg gtgggtcgcc gccgggagaa gcgtgagggg    120

acagatttgt gaccggcgcg gtttttgtca gcttactccg gccaaaaaag aactgcacct    180

ctggagcgga cttatttacc aagcattgga ggaatatcgt aggtaaaaat gcctattgga    240

tccaaagaga ggccaacatt ttttgaaatt tttaagacac gctgcaacaa agcagattta    300

ggaccaataa gtcttaattg gtttgaagaa ctttcttcag aagctccacc ctataattct    360

gaacctgcag aagaatctga acataaaaac aacaattacg aaccaaacct atttaaaact    420

ccacaaagga aaccatctta taatcagctg gcttcaactc caataatatt caaagagcaa    480

gggctgactc tgccgctgta ccaatctcct gtaaaagaat tagataaatt caaattagac    540

ttaggaagga atgttcccaa tagtagacat aaaagtcttc gcacagtgaa aactaaaatg    600

gatcaagcag atgatgtttc ctgtccactt ctaaattctt gtcttagtga aagtcctgtt    660

gttctacaat gtacacatgt aacaccacaa agagataagt cagtggtatg tgggagtttg    720

tttcatacac caaagtttgt gaagggtcgt cagacaccaa aacatatttc tgaaagtcta    780

ggagctgagg tggatcctga tatgtcttgg tcaagttctt tagctacacc acccaccctt    840

agttctactg tgctcatagt cagaaatgaa gaagcatctg aaactgtatt tcctcatgat    900

actactgcta atgtgaaaag ctatttttcc aatcatgatg aaagtctgaa gaaaaatgat    960

agatttatcg cttctgtgac agacagtgaa aacacaaatc aaagagaagc tgcaagtcat   1020

ggatttggaa aaacatcagg gaattcattt aaagtaaata gctgcaaaga ccacattgga   1080

aagtcaatgc caaatgtcct agaagatgaa gtatatgaaa cagttgtaga tacctctgaa   1140

gaagatagtt tttcattatg tttttctaaa tgtagaacaa aaaatctaca aaaagtaaga   1200

actagcaaga ctaggaaaaa aattttccat gaagcaaacg ctgatgaatg tgaaaaatct   1260

aaaaaccaag tgaaagaaaa atactcattt gtatctgaag tggaaccaaa tgatactgat   1320

ccattagatt caaatgtagc acatcagaag ccctttgaga gtggaagtga caaaatctcc   1380

aaggaagttg taccgtcttt ggcctgtgaa tggtctcaac taaccctttc aggtctaaat   1440

ggagcccaga tggagaaaat acccctattg catatttctt catgtgacca aaatatttca   1500

gaaaaagacc tattagacac agagaacaaa agaaagaaag attttcttac ttcagagaat   1560

tctttgccac gtatttctag cctaccaaaa tcagagaagc cattaaatga ggaaacagtg   1620

gtaaataaga gagatgaaga gcagcatctt gaatctcata cagactgcat tcttgcagta   1680

aagcaggcaa tatctggaac ttctccagtg gcttcttcat ttcagggtat caaaaagtct   1740

atattcagaa taagagaatc acctaaagag actttcaatg caagtttttc aggtcatatg   1800

actgatccaa actttaaaaa agaaactgaa gcctctgaaa gtggactgga aatacatact   1860

gtttgctcac agaaggagga ctccttatgt ccaaatttaa ttgataatgg aagctggcca   1920

gccaccacca cacagaattc tgtagctttg aagaatgcag gtttaatatc cactttgaaa   1980

aagaaaacaa ataagtttat ttatgctata catgatgaaa cattttataa aggaaaaaaa   2040

ataccgaaag accaaaaatc agaactaatt aactgttcag cccagtttga agcaaatgct   2100

tttgaagcac cacttacatt tgcaaatgct gattcaggtt tattgcattc ttctgtgaaa   2160

agaagctgtt cacagaatga ttctgaagaa ccaactttgt ccttaactag ctcttttggg   2220

acaattctga ggaaatgttc tagaaatgaa acatgttcta ataatacagt aatctctcag   2280

gatcttgatt ataaagaagc aaaatgtaat aaggaaaaac tacagttatt tattacccca   2340

gaagctgatt ctctgtcatg cctgcaggaa ggacagtgtg aaaatgatcc aaaaagcaaa   2400

aaagtttcag atataaaaga agaggtcttg gctgcagcat gtcacccagt acaacattca   2460

aaagtggaat acagtgatac tgactttcaa tcccagaaaa gtcttttata tgatcatgaa   2520

aatgccagca ctcttatttt aactcctact tccaaggatg ttctgtcaaa cctagtcatg   2580

atttctagag gcaaagaatc atacaaaatg tcagacaagc tcaaaggtaa caattatgaa   2640

tctgatgttg aattaaccaa aaatattccc atggaaaaga atcaagatgt atgtgcttta   2700

aatgaaaatt ataaaaacgt tgagctgttg ccacctgaaa aatacatgag agtagcatca   2760

ccttcaagaa aggtacaatt caaccaaaac acaaatctaa gagtaatcca aaaaaatcaa   2820

gaagaaacta cttcaatttc aaaaataact gtcaatccag actctgaaga acttttctca   2880

gacaatgaga ataattttgt cttccaagta gctaatgaaa ggaataatct tgctttagga   2940

aatactaagg aacttcatga aacagacttg acttgtgtaa acgaacccat tttcaagaac   3000

tctaccatgg ttttatatgg agacacaggt gataaacaag caacccaagt gtcaattaaa   3060

aaagatttgg tttatgttct tgcagaggag aacaaaaata gtgtaaagca gcatataaaa   3120

atgactctag gtcaagattt aaaatcggac atctccttga atatagataa aataccagaa   3180

aaaaataatg attacatgaa caaatgggca ggactcttag gtccaatttc aaatcacagt   3240

tttggaggta gcttcagaac agcttcaaat aaggaaatca agctctctga acataacatt   3300

aagaagagca aaatgttctt caaagatatt gaagaacaat atcctactag tttagcttgt   3360

gttgaaattg taaatacctt ggcattagat aatcaaaaga aactgagcaa gcctcagtca   3420

attaatactg tatctgcaca tttacagagt agtgtagttg tttctgattg taaaaatagt   3480

catataaccc ctcagatgtt attttccaag caggatttta attcaaacca taatttaaca   3540

cctagccaaa aggcagaaat tacagaactt tctactatat tagaagaatc aggaagtcag   3600

tttgaattta ctcagtttag aaaaccaagc tacatattgc agaagagtac atttgaagtg   3660

cctgaaaacc agatgactat cttaaagacc acttctgagg aatgcagaga tgctgatctt   3720

catgtcataa tgaatgcccc atcgattggt caggtagaca gcagcaagca atttgaaggt   3780

acagttgaaa ttaaacggaa gtttgctggc ctgttgaaaa atgactgtaa caaaagtgct   3840

tctggttatt taacagatga aaatgaagtg gggtttaggg gcttttattc tgctcatggc   3900

acaaaactga atgtttctac tgaagctctg caaaaagctg tgaaactgtt tagtgatatt   3960

gagaatatta gtgaggaaac ttctgcagag gtacatccaa taagtttatc ttcaagtaaa   4020

tgtcatgatt ctgttgtttc aatgtttaag atagaaaatc ataatgataa aactgtaagt   4080

gaaaaaaata ataaatgcca actgatatta caaaataata ttgaaatgac tactggcact   4140

tttgttgaag aaattactga aaattacaag agaaatactg aaaatgaaga taacaaatat   4200

actgctgcca gtagaaattc tcataactta gaatttgatg gcagtgattc aagtaaaaat   4260

gatactgttt gtattcataa agatgaaacg gacttgctat ttactgatca gcacaacata   4320

tgtcttaaat tatctggcca gtttatgaag gagggaaaca ctcagattaa agaagatttg   4380

tcagatttaa cttttttgga agttgcgaaa gctcaagaag catgtcatgg taatacttca   4440

aataaagaac agttaactgc tactaaaacg gagcaaaata taaaagattt tgagacttct   4500

gatacatttt ttcagactgc aagtgggaaa aatattagtg tcgccaaaga gtcatttaat   4560

aaaattgtaa atttctttga tcagaaacca gaagaattgc ataacttttc cttaaattct   4620

gaattacatt ctgacataag aaagaacaaa atggacattc taagttatga ggaaacagac   4680

atagttaaac acaaaatact gaaagaaagt gtcccagttg gtactggaaa tcaactagtg   4740

accttccagg gacaacccga acgtgatgaa aagatcaaag aacctactct gttgggtttt   4800

catacagcta gcgggaaaaa agttaaaatt gcaaaggaat ctttggacaa agtgaaaaac   4860

ctttttgatg aaaaagagca aggtactagt gaaatcacca gttttagcca tcaatgggca   4920

aagaccctaa agtacagaga ggcctgtaaa gaccttgaat tagcatgtga gaccattgag   4980

atcacagctg ccccaaagtg taaagaaatg cagaattctc tcaataatga taaaaacctt   5040

gtttctattg agactgtggt gccacctaag ctcttaagtg ataatttatg tagacaaact   5100

gaaaatctca aaacatcaaa aagtatcttt ttgaaagtta aagtacatga aaatgtagaa   5160

aaagaaacag caaaaagtcc tgcaacttgt tacacaaatc agtcccctta ttcagtcatt   5220

gaaaattcag ccttagcttt ttacacaagt tgtagtagaa aaacttctgt gagtcagact   5280

tcattacttg aagcaaaaaa atggcttaga gaaggaatat ttgatggtca accagaaaga   5340

ataaatactg cagattatgt aggaaattat ttgtatgaaa ataattcaaa cagtactata   5400

gctgaaaatg acaaaaatca tctctccgaa aaacaagata cttatttaag taacagtagc   5460

atgtctaaca gctattccta ccattctgat gaggtatata atgattcagg atatctctca   5520

aaaaataaac ttgattctgg tattgagcca gtattgaaga atgttgaaga tcaaaaaaac   5580

actagttttt ccaaagtaat atccaatgta aaagatgcaa atgcataccc acaaactgta   5640

aatgaagata tttgcgttga ggaacttgtg actagctctt caccctgcaa aaataaaaat   5700

gcagccatta aattgtccat atctaatagt aataattttg aggtagggcc acctgcattt   5760

aggatagcca gtggtaaaat cgtttgtgtt tcacatgaaa caattaaaaa agtgaaagac   5820

atatttacag acagtttcag taaagtaatt aaggaaaaca acgagaataa atcaaaaatt   5880

tgccaaacga aaattatggc aggttgttac gaggcattgg atgattcaga ggatattctt   5940

cataactctc tagataatga tgaatgtagc acgcattcac ataaggtttt tgctgacatt   6000

cagagtgaag aaattttaca acataaccaa aatatgtctg gattggagaa agtttctaaa   6060

atatcacctt gtgatgttag tttggaaact tcagatatat gtaaatgtag tatagggaag   6120

cttcataagt cagtctcatc tgcaaatact tgtgggattt ttagcacagc aagtggaaaa   6180

tctgtccagg tatcagatgc ttcattacaa aacgcaagac aagtgttttc tgaaatagaa   6240

gatagtacca agcaagtctt ttccaaagta ttgtttaaaa gtaacgaaca ttcagaccag   6300

ctcacaagag aagaaaatac tgctatacgt actccagaac atttaatatc ccaaaaaggc   6360

ttttcatata atgtggtaaa ttcatctgct ttctctggat ttagtacagc aagtggaaag   6420

caagtttcca ttttagaaag ttccttacac aaagttaagg gagtgttaga ggaatttgat   6480

ttaatcagaa ctgagcatag tcttcactat tcacctacgt ctagacaaaa tgtatcaaaa   6540

atacttcctc gtgttgataa gagaaaccca gagcactgtg taaactcaga aatggaaaaa   6600

acctgcagta aagaatttaa attatcaaat aacttaaatg ttgaaggtgg ttcttcagaa   6660

aataatcact ctattaaagt ttctccatat ctctctcaat ttcaacaaga caaacaacag   6720

ttggtattag gaaccaaagt ctcacttgtt gagaacattc atgttttggg aaaagaacag   6780

gcttcaccta aaaacgtaaa aatggaaatt ggtaaaactg aaactttttc tgatgttcct   6840

gtgaaaacaa atatagaagt ttgttctact tactccaaag attcagaaaa ctactttgaa   6900

acagaagcag tagaaattgc taaagctttt atggaagatg atgaactgac agattctaaa   6960

ctgccaagtc atgccacaca ttctcttttt acatgtcccg aaaatgagga aatggttttg   7020

tcaaattcaa gaattggaaa aagaagagga gagcccctta tcttagtggg agaaccctca   7080

atcaaaagaa acttattaaa tgaatttgac aggataatag aaaatcaaga aaaatcctta   7140

aaggcttcaa aaagcactcc agatggcaca ataaaagatc gaagattgtt tatgcatcat   7200

gtttctttag agccgattac ctgtgtaccc tttcgcacaa ctaaggaacg tcaagagata   7260

cagaatccaa attttaccgc acctggtcaa gaatttctgt ctaaatctca tttgtatgaa   7320

catctgactt tggaaaaatc ttcaagcaat ttagcagttt caggacatcc attttatcaa   7380

gtttctgcta caagaaatga aaaaatgaga cacttgatta ctacaggcag accaaccaaa   7440

gtctttgttc caccttttaa aactaaatca cattttcaca gagttgaaca gtgtgttagg   7500

aatattaact tggaggaaaa cagacaaaag caaaacattg atggacatgg ctctgatgat   7560

agtaaaaata agattaatga caatgagatt catcagttta acaaaaacaa ctccaatcaa   7620

gcagcagctg taactttcac aaagtgtgaa gaagaacctt tagatttaat tacaagtctt   7680

cagaatgcca gagatataca ggatatgcga attaagaaga aacaaaggca acgcgtcttt   7740

ccacagccag gcagtctgta tcttgcaaaa acatccactc tgcctcgaat ctctctgaaa   7800

gcagcagtag gaggccaagt tccctctgcg tgttctcata aacagctgta tacgtatggc   7860

gtttctaaac attgcataaa aattaacagc aaaaatgcag agtcttttca gtttcacact   7920

gaagattatt ttggtaagga aagtttatgg actggaaaag gaatacagtt ggctgatggt   7980

ggatggctca taccctccaa tgatggaaag gctggaaaag aagaatttta tagggctctg   8040

tgtgacactc caggtgtgga tccaaagctt atttctagaa tttgggttta taatcactat   8100

agatggatca tatggaaact ggcagctatg gaatgtgcct ttcctaagga atttgctaat   8160

agatgcctaa gcccagaaag ggtgcttctt ca                                 8192


<210>  950
<211>  3418
<212>  PRT
<213>  Homosapiens

<400>  950

Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala His Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Phe Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Ala Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210>  951
<211>  2107
<212>  DNA
<213>  Homosapiens

<400>  951
atgctcagaa tggagcagtg gacaaaggag acaaaaatcc ctgccttcat ggaacatgta     60

ttctatcaga gaaaaaaaat tctcaaggaa aaaaggcaat tttagcatct gctctgctct    120

gttctctcaa aaaataagca aaggatttca cagtgttcta ggtacttggg aatcatcagt    180

gaacaaaaca aagatcctgc ccttgtggac cttatgtgcc agaggctcct gaccaccata    240

aagatagaac tggggcttaa ccctcatcac ttctgaagct gatggaatga caattgcagc    300

atgactttcc cagggccctg attttcagca cggatgattt tttcttcagg gaagatggtg    360

cctatgagtt caatcctgac ttcctggagg aagctcatga atggaaccaa aaaagagcaa    420

gaaaagcaat gaggaatggc atatccccca ttattattga taataccaac ctccacgcct    480

gggaaatgaa gccctatgca gtcatggcac ttgaaaataa ctatgaagtt atattccgag    540

aacctgacac tcgctggaaa ttcaacgttc aagagttagc aagaagaaac attcatggtg    600

tctcaagaga aaaaatccac cgaatgaaag aacggtatga acacgatgtt acttttcaca    660

gtgtgcttca tgcagaaaag ccaagcagaa tgaacagaaa ccaggacagg aataatgcat    720

tgccttccaa caatgccaga tactggaatt cctacacaga gtttccaaac cggagggccc    780

acggtggatt tacaaatgag agctcctatc acagaagggg cggttgtcac catggatatt    840

agaggcctat cttacagcca ggcagaattt tcctaagtca gtttctactt cagtttttgt    900

tattttttgt tgcattttag tcagagctcc aattccagtg taaatagctg aactcaaaag    960

tttctgagca aagtcattat attcactttc ttcaccaaaa tttgttaaag tgcttctata   1020

tgcatggtct gatgctggga attctgcaga tttgagtaaa cagtctcttt ctctagggta   1080

agaatttgaa accaaaactt gagaacacac ccaagaatat atttacatag gttcatagat   1140

gaaataaagt gtttatatta tatataagct tcagtaccat ttgctctgaa gtgatctatt   1200

tattttttca ggaaattcat ctccatcggt aaagttggga aggtggagag aagtggtggg   1260

ggggcattgc tacttatcaa agtgccattg ctactttgat aatctatgta tctaaaaatg   1320

tgagatgtgc gactcttatg atactgattt tcctttaatg ttaatatgcc agaaagcata   1380

catctaaggg aacattgtcc ttcaaagtag acactttggg aagttatttc tttattttaa   1440

tgatgtatca ttgttaaaaa tgctgtcaaa tccttaatag ctacaggagc tactgaggga   1500

aatcagtgtc attatttaaa gtcacgcctt gtgtttttac tactttattc agcaggatta   1560

aacctgaata acttttggct gttgtgctaa tagtgtaaat aaaataagcc tgccttcata   1620

aaacactaac ttttaaaagg aataaacgac ttctaaaatt atgcctatta acatgtgtaa   1680

ttagtcggca gctcaaatgt ttgggagtgc aagaaattag gcaccccagg atataggtca   1740

tacagggata tataaaagcc atgctcatta caaaatgagc agttgatgtt ttatgtggca   1800

ttaagacaat caagtcctca caactctgga atgtcttctt atactgatgc tgaatttatg   1860

aatccaaatt aatttccaac aggttggaat cagatttaat gtgagatcat gatagacaag   1920

accacagagg acgtatgctc tatttcttgt tggccaacag cttctttcta atgttctgtg   1980

aaaaattatt ttaagtgtct tatataatgg tgcttttatg gttattaaaa attgtaaatg   2040

gtatcacatt tatatggatt tgtcattgga tctttttttg gttcaacaat aaaaaaattt   2100

aattacc                                                             2107


<210>  952
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  952

Met Arg Asn Gly Ile Ser Pro Ile Ile Ile Asp Asn Thr Asn Leu His 
1               5                   10                  15      


Ala Trp Glu Met Lys Pro Tyr Ala Val Met Ala Leu Glu Asn Asn Tyr 
            20                  25                  30          


Glu Val Ile Phe Arg Glu Pro Asp Thr Arg Trp Lys Phe Asn Val Gln 
        35                  40                  45              


Glu Leu Ala Arg Arg Asn Ile His Gly Val Ser Arg Glu Lys Ile His 
    50                  55                  60                  


Arg Met Lys Glu Arg Tyr Glu His Asp Val Thr Phe His Ser Val Leu 
65                  70                  75                  80  


His Ala Glu Lys Pro Ser Arg Met Asn Arg Asn Gln Asp Arg Asn Asn 
                85                  90                  95      


Ala Leu Pro Ser Asn Asn Ala Arg Tyr Trp Asn Ser Tyr Thr Glu Phe 
            100                 105                 110         


Pro Asn Arg Arg Ala His Gly Gly Phe Thr Asn Glu Ser Ser Tyr His 
        115                 120                 125             


Arg Arg Gly Gly Cys His His Gly Tyr 
    130                 135         


<210>  953
<211>  3273
<212>  DNA
<213>  Homosapiens

<400>  953
ttcagcaaaa caagctatcg atcagggaag atctccagtt ataatagata acactaatat     60

acaagcttgg gaaatgaagc catatgtgga agtggtaaat atgaaacatg agaaagtttt    120

tattttttat tcttgtcaat tttttcacat tctaaaattt tggctggttg gatcttgatt    180

attaaaacat ttgtcctttg ttttctaaag aggtttgttg gtttgcttag tttttaaaaa    240

aattgtgaat gatgtttttt aaggaacatg ttcatcttgt taatttttgt ttgttttttt    300

gagacggagt ctcgctctgt cacccaggct ggagtgcagt ggcaccatct tggctcactg    360

caagctccgc ctccccagtt gaagcgattc tcctgcctca gccacctgag tagctgggat    420

tataggtgcc tgcccccatg cccagctaat ttttgtattt ttagtagaga cagggtttca    480

ccgtgttggc cgggctggtc tcgaactcct gagctcagcc catctgccgt gctcagcctc    540

ccaaagtgct gggattacag gcatgagcca ccacgcccag cctcatattg ttttgacttt    600

ccttaaggat agtaatctta aggaattact attccttgag aatagtaatc aaaatttatc    660

cggttaaata gtcttaactg ttataaacca tattatttta taaagcgtca tttttcttgg    720

tcgagcaagt gtatagtatt gtcgaaatga aatttaactg tctgccttct ttttacttta    780

agaagtactt ctttgggttt ttgttttctt cctttccttt gtgtaggcca taggaaaagg    840

atacagagta gagtttcatg aacctgaaac ttggtggaaa tttgatcctg aagaattaga    900

aaagaggaat aaacatggtg tgtctcgaaa gaagattgct cagatgttgg atcgttatga    960

atatcaaatg tccatttcta ttgtaatgaa ttcagtggaa ccatcacaca aaagcacaca   1020

aagacctcct cctccacagg ggagacagag agaaagagtt ttgaagaaaa ctgggcatag   1080

gctcagcaaa accaaacaga agaggaacag aaaaagaaac aaaaagcaga acagtcagaa   1140

tagaatcatg gaggaaaact cattagaatt cttaagtgat cttacaccgg gagatcagga   1200

cccatctcag agtgaagagg aagacattga aaagaccaga agagaatcag aatatccctt   1260

cattgatggt ctacaaaatg aagtcggaga ttttgtgact ggatataaag aaaaaagatg   1320

gaaaaataaa gatcctaaag acagtttcca aaacgttatg tctatagttg aattagacaa   1380

cacaccaaag aattacctct ctaaggaagg tgataacttg tttgtaagtt tgttactgag   1440

gccaaatgaa atctccgtta cttgtccaat actgactcaa aacctttcct gtgtaacaac   1500

tgatgactgc tctggcatga aggtagaaaa gcatattaga aataggcata ccatagcatt   1560

agacacccag gacctttctg cggaaacttc atgcttattt atgaagaaga gagaaatagt   1620

agataaaaat ctctcacatg aacccattct gtgccatcaa catggaatca gaatgtcaga   1680

taaagtttta agagaggaac aagtgtatac aactaaaatc aatcactggg cttttttcac   1740

aaccaattta tctgatgaag atttacagct gggctctgac agacagccct attttggtag   1800

ctggcctgca ggacctcata agtttatatg tgaacagaga ccaaagaaag atagagcatg   1860

taagttggct ggtcctgaca gcagggggca atggattcaa atgatcttca cttcggtggc   1920

agcatcagaa ccaggaaaca atccagaaat attgacagac aaactactga taggaaatga   1980

agatttttca cctccacctg aaactatgga ttcattcata gaaacaaacc tcttcagaag   2040

ctgcttacct caaccggata taccaaagaa tgccttagaa tcaacaaaaa ataagaaaag   2100

gaggaagaaa aggattttca atttggtacc aaattttgac ttattaggac agagtcgtat   2160

cggtgtaaaa gaaagggaga aatgtgacct gttaacaaaa aaccatggac taaaaattac   2220

tttgggagaa gaaaaagata gaatttcaga aaggaacagt gaagaggaga ataaacaaaa   2280

acttatgacc tttgatcatc atccattgtg gttttacctt gatattatca aagctacccc   2340

tttaaatatt gatggacagc gttattctca ttgcctgtca tttaacagac taaggtgctc   2400

tgcatcttta tacaaaaatt atattccttc ttttgtgcta cataatttat ctagtatttg   2460

gaagccatct tttacaaaca agaaactgtt tttgactttc gaatctcaga caagagtagg   2520

taataaacta aatgatgcag ggtttatttc tccagaaatt ttacatagtc atcctgatac   2580

ttcgtgctct ttgggagtca cttctgattt tcacttttta aatgaaaggt ttgatagaaa   2640

gctgaaaaga tgggaagaac ctaaggaatt accagctgag gacagccaag acttaacaag   2700

cactgactac cgttcccttg agctaccatt atcacaaggg tttgcctttc aattagtaaa   2760

gctttttgga tctccaggcg ttccaatgga atccttgttg cctgatgact atgtggttcc   2820

ccttgactgg aagacactaa agatgatcta cttgcaatgg aagatgtcag tggagaaaag   2880

acagaagaag attggttgaa aaatgaaaat tccttgaact ttgagttctg ctgtcttcat   2940

ggtactgctg aagatcatga tcacggagaa aagtcagagt gctcagtgcc aacccaaggg   3000

attctttcca gagacgtacc cgttggatac caaaattagt ttggataatc tgttcaacca   3060

ttatatagcc tcgatgatga gagagttaca aagaacaaaa ctccagacac aaacctccaa   3120

atttttcagc agaagcactc tgcgtcgctg agctgaggtc ggctctgcga tccatacgtg   3180

gccgcaccca cacagcacgt gctgtgacga tggctgaacg gaaagtgtac actgttcctg   3240

aatattgaaa taaaacaata aacttttaat ggt                                3273


<210>  954
<211>  651
<212>  PRT
<213>  Homosapiens

<400>  954

Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile Ser Ile Val Met Asn 
1               5                   10                  15      


Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg Pro Pro Pro Pro Gln 
            20                  25                  30          


Gly Arg Gln Arg Glu Arg Val Leu Lys Lys Thr Gly His Arg Leu Ser 
        35                  40                  45              


Lys Thr Lys Gln Lys Arg Asn Arg Lys Arg Asn Lys Lys Gln Asn Ser 
    50                  55                  60                  


Gln Asn Arg Ile Met Glu Glu Asn Ser Leu Glu Phe Leu Ser Asp Leu 
65                  70                  75                  80  


Thr Pro Gly Asp Gln Asp Pro Ser Gln Ser Glu Glu Glu Asp Ile Glu 
                85                  90                  95      


Lys Thr Arg Arg Glu Ser Glu Tyr Pro Phe Ile Asp Gly Leu Gln Asn 
            100                 105                 110         


Glu Val Gly Asp Phe Val Thr Gly Tyr Lys Glu Lys Arg Trp Lys Asn 
        115                 120                 125             


Lys Asp Pro Lys Asp Ser Phe Gln Asn Val Met Ser Ile Val Glu Leu 
    130                 135                 140                 


Asp Asn Thr Pro Lys Asn Tyr Leu Ser Lys Glu Gly Asp Asn Leu Phe 
145                 150                 155                 160 


Val Ser Leu Leu Leu Arg Pro Asn Glu Ile Ser Val Thr Cys Pro Ile 
                165                 170                 175     


Leu Thr Gln Asn Leu Ser Cys Val Thr Thr Asp Asp Cys Ser Gly Met 
            180                 185                 190         


Lys Val Glu Lys His Ile Arg Asn Arg His Thr Ile Ala Leu Asp Thr 
        195                 200                 205             


Gln Asp Leu Ser Ala Glu Thr Ser Cys Leu Phe Met Lys Lys Arg Glu 
    210                 215                 220                 


Ile Val Asp Lys Asn Leu Ser His Glu Pro Ile Leu Cys His Gln His 
225                 230                 235                 240 


Gly Ile Arg Met Ser Asp Lys Val Leu Arg Glu Glu Gln Val Tyr Thr 
                245                 250                 255     


Thr Lys Ile Asn His Trp Ala Phe Phe Thr Thr Asn Leu Ser Asp Glu 
            260                 265                 270         


Asp Leu Gln Leu Gly Ser Asp Arg Gln Pro Tyr Phe Gly Ser Trp Pro 
        275                 280                 285             


Ala Gly Pro His Lys Phe Ile Cys Glu Gln Arg Pro Lys Lys Asp Arg 
    290                 295                 300                 


Ala Cys Lys Leu Ala Gly Pro Asp Ser Arg Gly Gln Trp Ile Gln Met 
305                 310                 315                 320 


Ile Phe Thr Ser Val Ala Ala Ser Glu Pro Gly Asn Asn Pro Glu Ile 
                325                 330                 335     


Leu Thr Asp Lys Leu Leu Ile Gly Asn Glu Asp Phe Ser Pro Pro Pro 
            340                 345                 350         


Glu Thr Met Asp Ser Phe Ile Glu Thr Asn Leu Phe Arg Ser Cys Leu 
        355                 360                 365             


Pro Gln Pro Asp Ile Pro Lys Asn Ala Leu Glu Ser Thr Lys Asn Lys 
    370                 375                 380                 


Lys Arg Arg Lys Lys Arg Ile Phe Asn Leu Val Pro Asn Phe Asp Leu 
385                 390                 395                 400 


Leu Gly Gln Ser Arg Ile Gly Val Lys Glu Arg Glu Lys Cys Asp Leu 
                405                 410                 415     


Leu Thr Lys Asn His Gly Leu Lys Ile Thr Leu Gly Glu Glu Lys Asp 
            420                 425                 430         


Arg Ile Ser Glu Arg Asn Ser Glu Glu Glu Asn Lys Gln Lys Leu Met 
        435                 440                 445             


Thr Phe Asp His His Pro Leu Trp Phe Tyr Leu Asp Ile Ile Lys Ala 
    450                 455                 460                 


Thr Pro Leu Asn Ile Asp Gly Gln Arg Tyr Ser His Cys Leu Ser Phe 
465                 470                 475                 480 


Asn Arg Leu Arg Cys Ser Ala Ser Leu Tyr Lys Asn Tyr Ile Pro Ser 
                485                 490                 495     


Phe Val Leu His Asn Leu Ser Ser Ile Trp Lys Pro Ser Phe Thr Asn 
            500                 505                 510         


Lys Lys Leu Phe Leu Thr Phe Glu Ser Gln Thr Arg Val Gly Asn Lys 
        515                 520                 525             


Leu Asn Asp Ala Gly Phe Ile Ser Pro Glu Ile Leu His Ser His Pro 
    530                 535                 540                 


Asp Thr Ser Cys Ser Leu Gly Val Thr Ser Asp Phe His Phe Leu Asn 
545                 550                 555                 560 


Glu Arg Phe Asp Arg Lys Leu Lys Arg Trp Glu Glu Pro Lys Glu Leu 
                565                 570                 575     


Pro Ala Glu Asp Ser Gln Asp Leu Thr Ser Thr Asp Tyr Arg Ser Leu 
            580                 585                 590         


Glu Leu Pro Leu Ser Gln Gly Phe Ala Phe Gln Leu Val Lys Leu Phe 
        595                 600                 605             


Gly Ser Pro Gly Val Pro Met Glu Ser Leu Leu Pro Asp Asp Tyr Val 
    610                 615                 620                 


Val Pro Leu Asp Trp Lys Thr Leu Lys Met Ile Tyr Leu Gln Trp Lys 
625                 630                 635                 640 


Met Ser Val Glu Lys Arg Gln Lys Lys Ile Gly 
                645                 650     


<210>  955
<211>  2825
<212>  DNA
<213>  Homosapiens

<400>  955
cggaggtgag gtttgttacc gcgattctga gaggtgggct tttagtccct ccagacctcg     60

gctttagtgc tgtctccgct tttctttcac cttcacagag gttcgtgtct tcctaaaaga    120

aggttttatt gggaggtaaa ggtcaatgcg taggggtaga gtaagatgtc ttatggtgaa    180

attgaaggta aattcttggg acctagagaa gaagtaacga gtgagccacg ctgtaaaaaa    240

ttgaagtcaa ccacagagtc gtatgttttt cacaatcata gtaatgctga ttttcacaga    300

atccaagaga aaactggaaa tgattgggtc cctgtgacca tcattgatgt cagaggacat    360

agttatttgc aggagaacaa aatcaaaact acagatttgc atagaccttt gcatgatgag    420

atgcctggta atagaccaga tgttattgaa tccattgatt cacaggtttt acaggaagca    480

cgtcctccat tagtatccgc agacgatgag atatatagca caagtaaagc atttatagga    540

cccatttaca aaccccctga gaaaaagaaa cgtaatgaag ggaggaatga ggcacatgtt    600

ctaaatggta taaatgacag aggaggacaa aaagagaaac agaaatttaa ctctgaaaaa    660

tcagagattg acaatgaatt attccagttt tacaaagaaa ttgaagagct tgaaaaggaa    720

aaagatggtt ttgagaacag ttgtaaagaa tctgaacctt ctcaggaaca atttgttcca    780

ttttatgagg gtcataataa tggtctctta aaacctgatg aagaaaagaa agatcttagt    840

aataaagcta tgccatcaca ttgtgattat cagcagaact tggggaatga gccagacaaa    900

tatccctgta atggacaagt aatacctaca ttttgtgaca cttcatttac ttctttcagg    960

cctgaatggc agtcagtata tccttttata gtgccctatg gtccccctct tcccagtttg   1020

aactatcatt taaacattca gagattcagt ggtccaccaa atccaccatc aaatattttc   1080

caagcccaag atgactctca gatacaaaat ggatattatg taaataattg tcatgttaac   1140

tggaattgca tgacttttga tcagaacaat gaatatactg actgtagtga gaataggagt   1200

agtgttcatc cctctggaaa tggctgcagt atgcaagatc gatatgtgag taatggtttc   1260

tgtgaagtca gagaaagatg ctggaaagat cattgtatgg acaagcataa tggaacagac   1320

aggtttgtga accagcagtt tcaagaggaa aagttaaata aattgcagaa gttacttatt   1380

cttttaagag gtctgcctgg ttctgggaaa acaacattgt ctcgaattct gcttggtcag   1440

aatcgtgatg gcattgtgtt cagcactgat gactattttc accatcaaga tgggtacagg   1500

tataatgtta atcaacttgg tgatgcccat gactggaacc agaacagagc aaaacaagct   1560

atcgatcagg gaagatctcc agttataata gataacacta atatacaagc ttgggaaatg   1620

aagccatatg tggaagtggc cataggaaaa ggatacagag tagagtttca tgaacctgaa   1680

acttggtgga aatttgatcc tgaagaatta gaaaagagga ataaacatgg tgtgtctcga   1740

aagaagattg ctcagatgtt ggatcgttat gaatatcaaa tgtccatttc tattgtaatg   1800

aattcagtgg aaccatcaca caaaagcaca caaagacctc ctcctccaca ggggagacag   1860

aggtggggag gctctcttgg ctcacataat cgtgtctgtg tcacaaataa tcattaaatt   1920

agctattttc agctaacaca tttgttgttg cacttgaaaa agagttagtg agcctgtctt   1980

ggagtttaag tagtttcaaa taaaaaaagg ctacagtgcc tcacaaagga tgttcccagc   2040

aagttgttta aattcccagc aagttgttaa agtgtaaata aaaatatatg aaattgtatt   2100

ttaaatgttt ttatattctc ttgttgtaat actcttggct gttatggaag cacctgagta   2160

atagagtggt gggtaggagc taggatgttt ttctacaatc gaattttaaa ctaatttatc   2220

tattttatag acactattga acagtttttt aatagttcat atctaaatct aacttttcat   2280

aaaactttac ggtttttcct tcactacctt aaatatgcaa gaaatactga cttggtatag   2340

ggtaccttag ttttctctat tcattagaca ggtaaaatta tatttcagct gattgatctg   2400

tgtgacaaaa ttatttctta gctataatca gcacatcact tagttcaaac aaaattcccc   2460

agcaaatgtt agatagtagg tatatcagtc acctggggag ttttcttcat aatatgcata   2520

ttcatcttgt aatgcataca tagttatcat cctccttctc aacccatctc cctaacccca   2580

catgcttgcc agttcttgaa gggataaagt gattctaata atgttttact tctctctgtt   2640

caatttaatg tgatataatt ctagtataaa aatattttgg acagttgctt aacatggtca   2700

taagaggatt tgtactatag aatatcttct agtactaatt tttctgtaga gcaaattata   2760

tttctctcac tggatagttt ttagatgtgt ttcttcatat aaaattaaaa actgagatgg   2820

aattc                                                               2825


<210>  956
<211>  583
<212>  PRT
<213>  Homosapiens

<400>  956

Met Ser Tyr Gly Glu Ile Glu Gly Lys Phe Leu Gly Pro Arg Glu Glu 
1               5                   10                  15      


Val Thr Ser Glu Pro Arg Cys Lys Lys Leu Lys Ser Thr Thr Glu Ser 
            20                  25                  30          


Tyr Val Phe His Asn His Ser Asn Ala Asp Phe His Arg Ile Gln Glu 
        35                  40                  45              


Lys Thr Gly Asn Asp Trp Val Pro Val Thr Ile Ile Asp Val Arg Gly 
    50                  55                  60                  


His Ser Tyr Leu Gln Glu Asn Lys Ile Lys Thr Thr Asp Leu His Arg 
65                  70                  75                  80  


Pro Leu His Asp Glu Met Pro Gly Asn Arg Pro Asp Val Ile Glu Ser 
                85                  90                  95      


Ile Asp Ser Gln Val Leu Gln Glu Ala Arg Pro Pro Leu Val Ser Ala 
            100                 105                 110         


Asp Asp Glu Ile Tyr Ser Thr Ser Lys Ala Phe Ile Gly Pro Ile Tyr 
        115                 120                 125             


Lys Pro Pro Glu Lys Lys Lys Arg Asn Glu Gly Arg Asn Glu Ala His 
    130                 135                 140                 


Val Leu Asn Gly Ile Asn Asp Arg Gly Gly Gln Lys Glu Lys Gln Lys 
145                 150                 155                 160 


Phe Asn Ser Glu Lys Ser Glu Ile Asp Asn Glu Leu Phe Gln Phe Tyr 
                165                 170                 175     


Lys Glu Ile Glu Glu Leu Glu Lys Glu Lys Asp Gly Phe Glu Asn Ser 
            180                 185                 190         


Cys Lys Glu Ser Glu Pro Ser Gln Glu Gln Phe Val Pro Phe Tyr Glu 
        195                 200                 205             


Gly His Asn Asn Gly Leu Leu Lys Pro Asp Glu Glu Lys Lys Asp Leu 
    210                 215                 220                 


Ser Asn Lys Ala Met Pro Ser His Cys Asp Tyr Gln Gln Asn Leu Gly 
225                 230                 235                 240 


Asn Glu Pro Asp Lys Tyr Pro Cys Asn Gly Gln Val Ile Pro Thr Phe 
                245                 250                 255     


Cys Asp Thr Ser Phe Thr Ser Phe Arg Pro Glu Trp Gln Ser Val Tyr 
            260                 265                 270         


Pro Phe Ile Val Pro Tyr Gly Pro Pro Leu Pro Ser Leu Asn Tyr His 
        275                 280                 285             


Leu Asn Ile Gln Arg Phe Ser Gly Pro Pro Asn Pro Pro Ser Asn Ile 
    290                 295                 300                 


Phe Gln Ala Gln Asp Asp Ser Gln Ile Gln Asn Gly Tyr Tyr Val Asn 
305                 310                 315                 320 


Asn Cys His Val Asn Trp Asn Cys Met Thr Phe Asp Gln Asn Asn Glu 
                325                 330                 335     


Tyr Thr Asp Cys Ser Glu Asn Arg Ser Ser Val His Pro Ser Gly Asn 
            340                 345                 350         


Gly Cys Ser Met Gln Asp Arg Tyr Val Ser Asn Gly Phe Cys Glu Val 
        355                 360                 365             


Arg Glu Arg Cys Trp Lys Asp His Cys Met Asp Lys His Asn Gly Thr 
    370                 375                 380                 


Asp Arg Phe Val Asn Gln Gln Phe Gln Glu Glu Lys Leu Asn Lys Leu 
385                 390                 395                 400 


Gln Lys Leu Leu Ile Leu Leu Arg Gly Leu Pro Gly Ser Gly Lys Thr 
                405                 410                 415     


Thr Leu Ser Arg Ile Leu Leu Gly Gln Asn Arg Asp Gly Ile Val Phe 
            420                 425                 430         


Ser Thr Asp Asp Tyr Phe His His Gln Asp Gly Tyr Arg Tyr Asn Val 
        435                 440                 445             


Asn Gln Leu Gly Asp Ala His Asp Trp Asn Gln Asn Arg Ala Lys Gln 
    450                 455                 460                 


Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn Thr Asn Ile 
465                 470                 475                 480 


Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile Gly Lys Gly 
                485                 490                 495     


Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys Phe Asp Pro 
            500                 505                 510         


Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg Lys Lys Ile 
        515                 520                 525             


Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile Ser Ile Val 
    530                 535                 540                 


Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg Pro Pro Pro 
545                 550                 555                 560 


Pro Gln Gly Arg Gln Arg Trp Gly Gly Ser Leu Gly Ser His Asn Arg 
                565                 570                 575     


Val Cys Val Thr Asn Asn His 
            580             


<210>  957
<211>  7444
<212>  DNA
<213>  Homosapiens

<400>  957
gctggctgcg gaaggggagg gggggggaga aggcgattgg atgcggcggc ggcggcggat     60

cccggagagc cccggagtga gcggagtagc gagtcggcaa cccggagggg tagaaatatt    120

tctgtcatgg ctcattcaaa gactaggacc aatgatggaa aaattacata tccgcctggg    180

gtcaaggaaa tatcagataa aatatctaaa gaggagatgg tgagacgatt aaagatggtt    240

gtgaaaactt ttatggatat ggaccaggac tctgaagaag aaaaggagct ttatttaaac    300

ctagctttac atcttgcttc agattttttt ctcaagcatc ctgataaaga tgttcgctta    360

ctggtagcct gctgccttgc tgatattttc aggatttatg ctcctgaagc tccttacaca    420

tcccctgata aactaaagga tatatttatg tttataacaa gacagttgaa ggggctagag    480

gatacaaaga gcccacaatt caataggtat ttttatttac ttgagaacat tgcttgggtc    540

aagtcatata acatatgctt tgagttagaa gatagcaatg aaattttcac ccagctatac    600

agaaccttat tttcagttat aaacaatggc cacaatcaga aagtccatat gcacatggta    660

gaccttatga gctctattat ttgtgaaggt gatacagtgt ctcaggagct tttggatacg    720

gttttagtaa atctggtacc tgctcataag aatttaaaca agcaagcata tgatttggca    780

aaggctttac tgaagaggac agctcaagct attgagccat atattaccaa tttttttaat    840

caggttctga tgcttgggaa aacatctatc agcgatttgt cagagcatgt ctttgactta    900

attttggagc tctacaatat tgatagtcat ttgctgctct ctgttttacc ccagcttgaa    960

tttaaattaa agagcaatga taatgaggag cgcctacaag ttgttaaact actggcaaaa   1020

atgtttgggg caaaggattc agaattggct tctcaaaaca agccactttg gcagtgctac   1080

ttgggcaggt ttaatgatat ccatgtacca atccgcctgg aatgtgtgaa atttgctagc   1140

cattgtctca tgaaccatcc tgatttagca aaagacttaa cagagtatct taaagtgagg   1200

tcacatgacc ctgaggaagc tattagacat gatgttattg tgtcaatagt tacagctgct   1260

aaaaaggata ttcttctggt caatgatcac ttacttaatt ttgtgagaga gagaacatta   1320

gacaaacgat ggagagtacg caaagaagcc atgatgggac ttgcccaaat ttataagaaa   1380

tatgctttac agtcagcagc tggaaaagat gctgcaaaac agatagcatg gatcaaagac   1440

aaattgctac atatatatta tcaaaatagt attgatgatc gactacttgt tgaacggatc   1500

tttgctcaat acatggttcc tcacaattta gaaactacag aacggatgaa atgcttatat   1560

tacttgtatg ccacactgga tttaaatgct gtgaaagcat tgaatgaaat gtggaaatgt   1620

caaaatctgc tccgacatca agtaaaggat ttgcttgact tgattaagca acccaaaaca   1680

gatgccagtg tcaaggccat attttcaaaa gtgatggtta ttacaagaaa tttacctgat   1740

cctggtaagg ctcaggattt catgaagaaa ttcacacagg tgttagaaga tgatgagaaa   1800

ataagaaagc agttagaagt acttgttagt ccaacatgct cctgcaagca ggctgaaggt   1860

tgtgtgcgtg aaataactaa gaagttgggc aaccccaaac agcctacaaa tcctttcctg   1920

gaaatgatca agtttctctt ggagaggata gcacctgtgc acatagatac cgaatctatc   1980

agtgctctta ttaaacaagt gaacaaatca atagatggaa cagcagatga tgaagatgag   2040

ggtgttccaa ctgatcaagc catcagagca ggtcttgaac tgcttaaggt actctcattt   2100

acacatccca tctcatttca ttctgctgaa acatttgaat cattactggc ttgtctgaaa   2160

atggatgatg aaaaagtagc agaagctgca ctacaaattt tcaaaaacac aggaagcaaa   2220

attgaagagg attttccaca catcagatca gccttgcttc ctgttttaca tcacaaatct   2280

aaaaaaggac ccccccgtca agccaaatat gccattcatt gtatccatgc gatattttct   2340

agtaaagaga cccagtttgc acagatattt gagcctctgc ataagagcct agatccaagc   2400

aacctggaac atctcataac accattggtt actattggtc atattgctct ccttgcacct   2460

gatcaatttg ctgctccttt gaaatctttg gtagctactt tcattgtgaa agatcttctc   2520

atgaatgatc ggcttccagg gaaaaagaca actaaacttt gggttccaga tgaagaagta   2580

tctcctgaga caatggtcaa aattcaggct attaaaatga tggttcgatg gctacttgga   2640

atgaaaaata atcacagtaa atcaggaact tctaccttaa gattgctaac aacaatattg   2700

catagtgatg gagacttgac agaacagggg aaaattagta aaccagatat gtcacgtctg   2760

agacttgctg ctgggagtgc tattgtgaag ctggcacaag aaccctgtta ccatgaaatc   2820

atcacattag aacaatatca gctatgtgca ttagctatca acgatgaatg ctatcaagta   2880

agacaagtgt ttgcccagaa acttcacaaa ggcctttccc gtttacggct tccacttgag   2940

tatatggcaa tctgtgccct ttgtgcaaaa gatcctgtaa aggagagaag agctcatgct   3000

aggcaatgtt tggtgaaaaa tataaatgta aggcgggagt atctgaagca gcatgcagct   3060

gttagtgaaa aattattgtc tcttctacca gagtatgttg ttccatatac aattcacctt   3120

ttggcacatg acccagatta tgtcaaagta caggatattg aacaacttaa agatgttaaa   3180

gaatgtcttt ggtttgttct ggaaatatta atggctaaaa atgaaaataa cagtcacgct   3240

tttatcagaa agatggtaga aaatattaaa caaacaaaag atgcccaagg accagatgat   3300

gcaaaaatga atgaaaaact gtacactgtg tgtgatgttg ccatgaatat catcatgtca   3360

aagagtacta catacagttt ggaatctcct aaagacccgg tactaccagc tcgtttcttc   3420

actcaacctg acaagaattt cagtaacacc aaaaattatc tgcctcctga aatgaaatca   3480

tttttcactc ctggaaaacc taaaacaacc aatgttctag gagctgttaa caagccactt   3540

tcatcagcag gcaagcaatc tcagaccaaa tcatcacgaa tggaaactgt aagcaatgca   3600

agcagcagct caaatccaag ctctcctgga agaataaagg ggaggcttga tagttctgaa   3660

atggatcaca gtgaaaatga agattacaca atgtcttcac ctttgccggg gaaaaaaagt   3720

gacaagagag acgactctga tcttgtaagg tctgaattgg agaagcctag aggcaggaaa   3780

aaaacgcccg tcacagaaca ggaggagaaa ttaggtatgg atgacttgac taagttggta   3840

caggaacaga aacctaaagg cagtcagcga agtcggaaaa gaggccatac ggcttcagaa   3900

tctgatgaac agcagtggcc tgaggaaaag aggctcaaag aagatatatt agaaaatgaa   3960

gatgaacaga atagtccgcc aaaaaagggt aaaagaggcc gaccaccaaa acctcttggt   4020

ggaggtacac caaaagaaga gccaacaatg aaaacttcta aaaaaggaag caaaaaaaaa   4080

tctggacctc cagcaccaga ggaggaggaa gaagaagaaa gacaaagtgg aaatacggaa   4140

cagaagtcca aaagcaaaca gcaccgagtg tcaaggagag cacagcagag agcagaatct   4200

cctgaatcta gtgcaattga atccacacag tccacaccac agaaaggacg aggaagacca   4260

tcaaaaacgc catcaccatc acaaccaaaa aaaaatgtcc gtgtaggacg ctccaaacaa   4320

gcagctacta aggaaaatga ttcaagtgaa gaagtagatg tgtttcaggg tagctctcct   4380

gtcgatgata ttccacagga agaaacagag gaggaggaag tttctacagt aaatgtacgg   4440

cggcgaagtg ctaaaaggga acggcgatga acaaatgtaa ttaataactt tctctgtgaa   4500

agctttggaa aaatcttttt tttttttttt tttttttggt caagcttgag gctgaataaa   4560

gcctttgatg cacaaaatgg gactgctgaa gagtggacag ttggacctta ctttggtgac   4620

cccatacatt tgtggtcaca tgctttagcc atacacatgg taacattgac tatggagtct   4680

tgtgaaagtg taatgtgcga tggctatgta gacataaaga agaaacttgt aaatatcttt   4740

tttctttttt ttaatgtttc tgatttctga agtgcttgta tagcttttat ctgcggcttt   4800

aaactgacag tacccgactg tttattggat ctattgattt gaaaagaatt tgttaggata   4860

gatcttaagc agtaatctgt cagtgtttgt atttgtattc tctgcaattt tactgtgaaa   4920

aaaaatttgt tttcaacaat tggtgtcatt ttcttgatgt cactatttgt tggagagtta   4980

aatggtctct tccctttgtg tatcttacct agtgtttact cctgggcacc cttaatcttc   5040

agaggtgcta aattgtctgc cattacacca gaaggatgcc tctgatagga ggacaaccat   5100

gcaaattgtg aaatagtcct gaagttcttg gattacttta cacctcagta ttgatttgtc   5160

ccagaatttt ctggcctttc atggcaatga aaattttaag aagaaagatt taaagtattt   5220

taattttaaa gagtgtgtta taaaataatg tactgaattc tttatcccat tttatcatcc   5280

tttcagtttt tattaatcta ctgtatcaat aaaattctgt aatttgaatg agtttttaat   5340

agtctagaat gttattgtgt atagatattt cctcttgaac gttatgttca gaaaatgcaa   5400

attacactat aatataaaac ctgatatata cacattagaa atattccagt tctccgtaac   5460

agtgtaaagt taatcagaaa gaaaaaattt tattgatgca gtgtgtcttt ataaagctgt   5520

tcttgaaagc caagtgtttt gtattttata gtgagttgca tgtttttgaa aaaaagtgct   5580

gaaaatggga tgtgctgttt tctgtaaatt catatttagc catagtatat gatagattgc   5640

cccataacat agtttttcat caagagttta ttattgtact ttattttgga gccaaaaaat   5700

tgattctggg gggtgggggc agcgtagaag tggtatatcc aagtatatca gctactgtag   5760

ttgtcacagt cttgtgaact ttgaatgaaa ttccactttg tccagattgg gagaagtgga   5820

aatttatttg gatttagagc aggtcttttt ttttcttcat tgtaatctgc aaaatgtaga   5880

aataaattac ttaaggcagt atcctttata cagttgtata aactgtattt tgaaccaaaa   5940

catataggtt actacttaat gcttacctaa tttcatttta gtattttagg tgctgttatg   6000

ttttttcatg gttaacacca gaggggaaaa aatcatattc taacttatta aatttatcac   6060

attgaatagt ggaacatttt catatgatac accattatgt ttaagatata tttccaagat   6120

tggttataat agatggggca tataataaag aagctactat tttggaaaat gacattttac   6180

tatttgccaa tgtatattgc aattgatgtg attatttttc ttttaaagat ttgtttgtgt   6240

ttatgaaaca gccatttatt ttttaaaaag tgttttgaat tgtgtcttaa tctctccata   6300

ttcaactatt cttcatttac aacaatagtg acaccagtaa ttatgagagg ctgtcatata   6360

tcaaagcagc tcaggtggga tcaacataca ttggttttga aatgtttcct tagctcggtt   6420

ctcccaaaca cataatttct gtttcagcag tacaaaggca tgttttaaaa tctataacat   6480

aaagaataag gaatagcttt gtatttttgt cattgattaa attgcaccag aaatgtttat   6540

ggaaatatta agaacatttt ataaaacata cgaaaaagtg attgtgaagg atttttattt   6600

gcatgattat agttaagcaa atttcatttc acatttttgt aatgctgtac agcagttcac   6660

aaaaaaatgt tcattgtaga ttttgttatg ttcaatgcca atgagtctgt aattttacga   6720

cctgtctgtt ctttttttgg gtggattacg atgtaaattt ttcttttctt tctttctttt   6780

tttttttttt tgtgtagaaa aataggtgca ataatgatca aagttttgat gtcttgagtc   6840

tccatcttag gggattatct tacgtttaag cttaacattt catgtagtaa gatttggaga   6900

gccacatact ttacagtaaa attaagtgtg tataaaacat taattgctaa caattgttag   6960

caaactattt cagtgataat gttcattttg aaaatatgta ctgtataaca ttaagaaaat   7020

atttaactcc ctgtaacaag ttccattatg aaaatcttat tcctcagtga ggttatcttg   7080

ctgcactctg tagcaaattt gtttaatcta cattataata aaatttcttg ctgcagtgca   7140

acaggaggct ttttcagtga tcttcactgt atatgtaaat tacaaatgtg gctgtaaaac   7200

ttattccagg tattaaaggt taaattgctt tctatatctt cttataactt gtaagtctga   7260

tttttaagat ttccttttgt ccacttgtaa gaatgtcagg aatttaagaa tttgtttaaa   7320

ttaggcatat ctctgccatc acatagtatt atgtcaccat aatgaacaat tgctatttaa   7380

atagataacc aattttcaga cacatttttg gatttctgtg aagttgaata aacataaaag   7440

ctaa                                                                7444


<210>  958
<211>  1447
<212>  PRT
<213>  Homosapiens

<400>  958

Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro 
1               5                   10                  15      


Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val 
            20                  25                  30          


Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp 
        35                  40                  45              


Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val 
65                  70                  75                  80  


Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro 
                85                  90                  95      


Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg 
            100                 105                 110         


Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr 
        115                 120                 125             


Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys 
    130                 135                 140                 


Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr 
145                 150                 155                 160 


Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His 
                165                 170                 175     


Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser 
            180                 185                 190         


Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys 
        195                 200                 205             


Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg 
    210                 215                 220                 


Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val 
225                 230                 235                 240 


Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Phe 
                245                 250                 255     


Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser 
            260                 265                 270         


Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu 
        275                 280                 285             


Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp 
    290                 295                 300                 


Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly 
305                 310                 315                 320 


Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe 
                325                 330                 335     


Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr 
            340                 345                 350         


Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His 
        355                 360                 365             


Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu 
    370                 375                 380                 


Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr 
                405                 410                 415     


Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln 
            420                 425                 430         


Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser 
        435                 440                 445             


Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val 
    450                 455                 460                 


Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu 
465                 470                 475                 480 


Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp 
                485                 490                 495     


Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu 
            500                 505                 510         


Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys 
        515                 520                 525             


Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp 
    530                 535                 540                 


Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala 
                565                 570                 575     


Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln 
            580                 585                 590         


Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile 
        595                 600                 605             


Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln 
    610                 615                 620                 


Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val 
625                 630                 635                 640 


Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu 
                645                 650                 655     


Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser 
            660                 665                 670         


Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala 
        675                 680                 685             


Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro 
    690                 695                 700                 


His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys 
705                 710                 715                 720 


Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile 
                725                 730                 735     


Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His 
            740                 745                 750         


Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val 
        755                 760                 765             


Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro 
    770                 775                 780                 


Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn 
785                 790                 795                 800 


Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu 
                805                 810                 815     


Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met 
            820                 825                 830         


Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr 
        835                 840                 845             


Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu 
    850                 855                 860                 


Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu 
865                 870                 875                 880 


Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His 
                885                 890                 895     


Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn 
            900                 905                 910         


Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys 
        915                 920                 925             


Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala 
    930                 935                 940                 


Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln 
945                 950                 955                 960 


Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His 
                965                 970                 975     


Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val 
            980                 985                 990         


Pro Tyr Thr Ile His Leu Leu Ala  His Asp Pro Asp Tyr  Val Lys Val 
        995                 1000                 1005             


Gln Asp  Ile Glu Gln Leu Lys  Asp Val Lys Glu Cys  Leu Trp Phe 
    1010                 1015                 1020             


Val Leu  Glu Ile Leu Met Ala  Lys Asn Glu Asn Asn  Ser His Ala 
    1025                 1030                 1035             


Phe Ile  Arg Lys Met Val Glu  Asn Ile Lys Gln Thr  Lys Asp Ala 
    1040                 1045                 1050             


Gln Gly  Pro Asp Asp Ala Lys  Met Asn Glu Lys Leu  Tyr Thr Val 
    1055                 1060                 1065             


Cys Asp  Val Ala Met Asn Ile  Ile Met Ser Lys Ser  Thr Thr Tyr 
    1070                 1075                 1080             


Ser Leu  Glu Ser Pro Lys Asp  Pro Val Leu Pro Ala  Arg Phe Phe 
    1085                 1090                 1095             


Thr Gln  Pro Asp Lys Asn Phe  Ser Asn Thr Lys Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Pro Glu  Met Lys Ser Phe Phe  Thr Pro Gly Lys Pro  Lys Thr Thr 
    1115                 1120                 1125             


Asn Val  Leu Gly Ala Val Asn  Lys Pro Leu Ser Ser  Ala Gly Lys 
    1130                 1135                 1140             


Gln Ser  Gln Thr Lys Ser Ser  Arg Met Glu Thr Val  Ser Asn Ala 
    1145                 1150                 1155             


Ser Ser  Ser Ser Asn Pro Ser  Ser Pro Gly Arg Ile  Lys Gly Arg 
    1160                 1165                 1170             


Leu Asp  Ser Ser Glu Met Asp  His Ser Glu Asn Glu  Asp Tyr Thr 
    1175                 1180                 1185             


Met Ser  Ser Pro Leu Pro Gly  Lys Lys Ser Asp Lys  Arg Asp Asp 
    1190                 1195                 1200             


Ser Asp  Leu Val Arg Ser Glu  Leu Glu Lys Pro Arg  Gly Arg Lys 
    1205                 1210                 1215             


Lys Thr  Pro Val Thr Glu Gln  Glu Glu Lys Leu Gly  Met Asp Asp 
    1220                 1225                 1230             


Leu Thr  Lys Leu Val Gln Glu  Gln Lys Pro Lys Gly  Ser Gln Arg 
    1235                 1240                 1245             


Ser Arg  Lys Arg Gly His Thr  Ala Ser Glu Ser Asp  Glu Gln Gln 
    1250                 1255                 1260             


Trp Pro  Glu Glu Lys Arg Leu  Lys Glu Asp Ile Leu  Glu Asn Glu 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ser Pro Pro  Lys Lys Gly Lys Arg  Gly Arg Pro 
    1280                 1285                 1290             


Pro Lys  Pro Leu Gly Gly Gly  Thr Pro Lys Glu Glu  Pro Thr Met 
    1295                 1300                 1305             


Lys Thr  Ser Lys Lys Gly Ser  Lys Lys Lys Ser Gly  Pro Pro Ala 
    1310                 1315                 1320             


Pro Glu  Glu Glu Glu Glu Glu  Glu Arg Gln Ser Gly  Asn Thr Glu 
    1325                 1330                 1335             


Gln Lys  Ser Lys Ser Lys Gln  His Arg Val Ser Arg  Arg Ala Gln 
    1340                 1345                 1350             


Gln Arg  Ala Glu Ser Pro Glu  Ser Ser Ala Ile Glu  Ser Thr Gln 
    1355                 1360                 1365             


Ser Thr  Pro Gln Lys Gly Arg  Gly Arg Pro Ser Lys  Thr Pro Ser 
    1370                 1375                 1380             


Pro Ser  Gln Pro Lys Lys Asn  Val Arg Val Gly Arg  Ser Lys Gln 
    1385                 1390                 1395             


Ala Ala  Thr Lys Glu Asn Asp  Ser Ser Glu Glu Val  Asp Val Phe 
    1400                 1405                 1410             


Gln Gly  Ser Ser Pro Val Asp  Asp Ile Pro Gln Glu  Glu Thr Glu 
    1415                 1420                 1425             


Glu Glu  Glu Val Ser Thr Val  Asn Val Arg Arg Arg  Ser Ala Lys 
    1430                 1435                 1440             


Arg Glu  Arg Arg 
    1445         


<210>  959
<211>  5253
<212>  DNA
<213>  Homosapiens

<400>  959
ccggagagcc ccggagtgag cggagtagcg agtcggcaac ccggaggggt agaaatattt     60

ctgtcatggc tcattcaaag actaggacca atgatggaaa aattacatat ccgcctgggg    120

tcaaggaaat atcagataaa atatctaaag aggagatggt gagacgatta aagatggttg    180

tgaaaacttt tatggatatg gaccaggact ctgaagaaga aaaggagctt tatttaaacc    240

tagctttaca tcttgcttca gatttttttc tcaagcatcc tgataaagat gttcgcttac    300

tggtagcctg ctgccttgct gatattttca ggatttatgc tcctgaagct ccttacacat    360

cccctgataa actaaaggat atatttatgt ttataacaag acagttgaag gggctagagg    420

atacaaagag cccacagttc aataggtatt tttatttgct tgagaacatt gcttgggtca    480

agtcatataa catatgcttt gagttagaag atagcaatga aattttcacc cagctataca    540

gaaccttatt ttcagttata aacaatggcc acaatcagaa agtccatatg cacatggtag    600

accttatgag ctctattatt tgtgaaggtg atacagtgtc tcaggagctt ttggatacgg    660

ttttagtaaa tctggtacct gctcataaga atttaaacaa gcaagcatat gatttggcaa    720

aggctttact gaagaggaca gctcaagcta ttgagccata tattaccaat ttttttaatc    780

aggttctgat gcttgggaaa acatctatca gcgatttgtc agagcatgtc tctgacttaa    840

ttttggagct ctacaatatt gatagtcatt tgctgctctc tgttttaccc cagcttgaat    900

ttaaattaaa gagcaatgat aatgaggagc gcctacaagt tgttaaacta ctggcgaaaa    960

tgtttggggc aaaggattca gaattggctt ctcaaaacaa gccactttgg cagtgctact   1020

tgggcaggtt taatgatatc catgtaccaa tccgcctgga atgtgtgaaa tttgctagcc   1080

attgtctcat gaaccatcct gatttagcaa aagacttaac agagtatctt aaagtgaggt   1140

cacatgaccc tgaggaagct attagacatg atgttattgt gtcaatagtt acagctgcta   1200

aaaaggatat tcttctggtc aatgatcact tacttaattt tgtgggagag agaacattag   1260

acaaacgatg gagagtacgc aaagaagcca tgatgggact tgcccaaatt tataagaaat   1320

atgctttaca gtcagcagct ggaaaagatg ctgcaaaaca gatagcatgg atcaaagaca   1380

aattgctaca tatatattat caaaatagta ttgatgatcg actacttgtt gaacggatct   1440

ttgctcaata catggttcct cacaatttag aaactacaga acggatgaaa tgcttatatt   1500

acttgtatgc cacactggat ttaaatgctg tgaaagcatt gaatgaaatg tggaaatgtc   1560

aaaatctgct ccgacatcaa gtaaaggatt tgcttgactt gattaagcaa cccaaaacag   1620

atgccagtgt caaggccata ttttcaaaag tgatggttat tacaagaagt ttacctgatc   1680

ctggtaaggc tcaggatttc atgaagaaat tcacacaggt gttagaagat gatgagaaaa   1740

taagaaagca gttagaagta cttgttagtc caacatgctc ctgcaagcag gctgaaggtt   1800

gtgtgcgtga aataactaag aagttgggca accccaaaca gcctacaaat cctttcctgg   1860

aaatgatcaa gtttctcttg gagaggatag cacctgtgca catagatacc gaatctatca   1920

gtgctcttat taaacaagtg aacaaatcaa tagatggaac agcagatgat gaagatgagg   1980

gtgttccaac tgatcaagcc atcagagcag gtcttgaact gcttaaggta ctctcattta   2040

cacatcccat ctcatttcat tctgctgaaa catttgaatc attactggcc tgtctgaaaa   2100

tggatgatga aaaagtagca gaagctgcac tacaaatttt caaaaacaca ggaagcaaaa   2160

ttgaagagga ttttccacac atcagatcag ccttgcttcc tgttttacat cacaaatcta   2220

aaaaaggacc cccccgtcaa gccaaatatg ccattcattg tatccatgcg atattttcta   2280

gtaaagaggc ccagtttgca cagatatttg agcctctgca taagagccta gatccaagca   2340

acctggaaca tctcataaca ccattggtta ctattggtca tattgctctc cttgcacctg   2400

atcaatttgc tgctcctttg aaatctttgg tagctacttt cattgtgaaa gatcttctca   2460

tgaatgatcg gcttccaggg aaaaagacaa ctaaactttg ggttccagat gaagaagtat   2520

ctcctgagac aatggtcaaa attcaggcta ttaaaatgat ggttcgatgg ctacttggaa   2580

tgaaaaataa tcacagtaaa tcaggaactt ctaccttaag attgctaaca acaatattgc   2640

atagtgatgg agacttgaca gaacagggga aaattagtaa accagatatg tcacgtctga   2700

gacttgctgc tgggagtgct attgtgaagc tggcacaaga accctgttac catgaaatca   2760

tcacattaga acaatatcag ctatgtgcat tagctatcaa cgatgaatgc tatcaagtaa   2820

gacaagtgtt tgcccagaaa cttcacaaag gcctttcccg tttacggctt ccacttgagt   2880

atatggcaat ctgtgccctt tgtgcaaaag atcctgtaaa ggagagaaga gctcatgcta   2940

ggcaatgttt ggtgaaaaat ataaatgtaa ggcgggagta tctgaagcag catgcagctg   3000

ttagtgaaaa attattgtct cttctaccag agtatgttgt tccatataca attcaccttt   3060

tggcacatga cccagattat gtcaaagtac aggatattga acaacttaaa gatgttaaag   3120

aatgtctttg gtttgttctg gaaatattaa tggctaaaaa tgaaaataac agtcacgctt   3180

ttatcagaaa gatggtagaa aatattaagc aaacaaaaga tgcccaagga ccagatgatg   3240

caaaaatgaa tgaaaaactg tacactgtgt gtgatgttgc catgaatatc atcatgtcaa   3300

agagtactac atacagtttg gaatctccta aagacccggt actaccagct cgtttcttca   3360

ctcaacctga caagaatttc agtaacacca aaaattatct gcctcctgga atgaaatcat   3420

ttttcactcc tggaaaacct aaaacaacca atgttctagg agctgttaac aagccacttt   3480

catcagcagg caagcaatct cagaccaaat catcacgaat ggaaactgta ggcaatgcaa   3540

gcagcagctc aaatccaagc tctcctggaa gaataaaggg gaggcttgat agttctgaaa   3600

tggatcacag tgaaaatgaa gattacacaa tgtcttcacc tttgccgggg aaaagaagtg   3660

acaagagaga cgactctgat cttgtaaggt ctgaattgga gaagcctaga ggcagaaaaa   3720

aaacgcccgt cacagaacgg gaggagaaat taggtatgga tgacttgact aagttggtac   3780

aggaacagag acctaaaggc agtcagcgaa gtcggaaaag aggccatacg gcttcagaat   3840

ctgatgaaca gcagtggcct gaggaaaaga ggctcaaaga agatatatta gaaaatgaag   3900

atgaacagaa tagtccgcca aaaaagggta aaagaggccg accaccaaaa cctcttggtg   3960

gaggtacacc aaaagaagag ccaacaatga aaacttctaa aaaaggaagc aaaaaaaaat   4020

ctggacctcc agcaccagag gaggaggaag aagaagaaag acaaagtgga aatacggaac   4080

agaagtccaa aagcaaacag caccgagtgt caaggagagc acagcagaga gcagaatctt   4140

ctgaatctag tgcaattgaa tccacacagt ccacaccaca gaaaggacga ggaagaccat   4200

caaaaacgcc atcaccatca caaccaaaaa aaaatgtgta agttgtaaat attacatttc   4260

aaaccaattt caaattattt tgcaaaagtt cctaaatttg taaacataca tattgctgta   4320

tttaaattcc atatatttag ccccattaca ctaggtacgg cggcgaagtg ctaaaaggga   4380

acggcgatga acaaatgtaa ttaataactt tctctgtgaa agctttggaa aaatcttttt   4440

tttttttttt tttttttggt caagcttgag gctgaataaa gcctttgatg cacaaaatgg   4500

gactgctgaa gagtggacag ttggacctta ctttggtgac cccatacatt tgtggtcaca   4560

tgctttagcc atacacatgg taacattgac tatggagtct tgtgaaagtg taatgtgcga   4620

tggctatgta gacataaaga agaaacttgt aaatatcttt tttctttttt ttaatgtttc   4680

tgatttctga agtgcttgta tagcttttat ctgcggcttt aaactgacag tacccgactg   4740

tttattggat ctattgattt gaaaagaatt tgttaggata gatcttaagc agtaatctgt   4800

cagtgtttgt atttgtattt tctgcaattt tactgtgaaa aaaaatttgt tttcaacaat   4860

tggtgtcatt ttcttgatgt cactatttgt tggagagtta aatggtctct tccctttgtg   4920

tatcttacct agtgtttact cctgggcacc cttaatcttc agaggtgcta aattgtctgc   4980

cattacacca gaaggatgcc tctgatagga ggacaaccat gcaaattgtg aaatagtcct   5040

gaagttcttg gattacttta cacctcagta ttgatttgtc ccagaatttt ctggcctttc   5100

atggcaatga aaattttaag aagaaagatt taaagtattt taattttaaa gagtgtgtta   5160

taaaataatg tactgaattc tttatcccat tttatcatcc tttcagtttt tattaatcta   5220

ctgtatcaat aaaattctgt aatttgaatg agt                                5253


<210>  960
<211>  1391
<212>  PRT
<213>  Homosapiens

<400>  960

Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro 
1               5                   10                  15      


Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val 
            20                  25                  30          


Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp 
        35                  40                  45              


Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala 
    50                  55                  60                  


Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val 
65                  70                  75                  80  


Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro 
                85                  90                  95      


Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg 
            100                 105                 110         


Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr 
        115                 120                 125             


Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys 
    130                 135                 140                 


Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr 
145                 150                 155                 160 


Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His 
                165                 170                 175     


Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser 
            180                 185                 190         


Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys 
        195                 200                 205             


Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg 
    210                 215                 220                 


Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val 
225                 230                 235                 240 


Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Ser 
                245                 250                 255     


Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser 
            260                 265                 270         


Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu 
        275                 280                 285             


Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp 
    290                 295                 300                 


Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly 
305                 310                 315                 320 


Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe 
                325                 330                 335     


Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr 
            340                 345                 350         


Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His 
        355                 360                 365             


Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu 
    370                 375                 380                 


Val Asn Asp His Leu Leu Asn Phe Val Gly Glu Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr 
                405                 410                 415     


Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln 
            420                 425                 430         


Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser 
        435                 440                 445             


Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val 
    450                 455                 460                 


Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu 
465                 470                 475                 480 


Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp 
                485                 490                 495     


Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu 
            500                 505                 510         


Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys 
        515                 520                 525             


Val Met Val Ile Thr Arg Ser Leu Pro Asp Pro Gly Lys Ala Gln Asp 
    530                 535                 540                 


Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala 
                565                 570                 575     


Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln 
            580                 585                 590         


Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile 
        595                 600                 605             


Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln 
    610                 615                 620                 


Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val 
625                 630                 635                 640 


Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu 
                645                 650                 655     


Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser 
            660                 665                 670         


Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala 
        675                 680                 685             


Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro 
    690                 695                 700                 


His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys 
705                 710                 715                 720 


Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile 
                725                 730                 735     


Phe Ser Ser Lys Glu Ala Gln Phe Ala Gln Ile Phe Glu Pro Leu His 
            740                 745                 750         


Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val 
        755                 760                 765             


Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro 
    770                 775                 780                 


Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn 
785                 790                 795                 800 


Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu 
                805                 810                 815     


Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met 
            820                 825                 830         


Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr 
        835                 840                 845             


Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu 
    850                 855                 860                 


Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu 
865                 870                 875                 880 


Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His 
                885                 890                 895     


Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn 
            900                 905                 910         


Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys 
        915                 920                 925             


Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala 
    930                 935                 940                 


Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln 
945                 950                 955                 960 


Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His 
                965                 970                 975     


Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val 
            980                 985                 990         


Pro Tyr Thr Ile His Leu Leu Ala  His Asp Pro Asp Tyr  Val Lys Val 
        995                 1000                 1005             


Gln Asp  Ile Glu Gln Leu Lys  Asp Val Lys Glu Cys  Leu Trp Phe 
    1010                 1015                 1020             


Val Leu  Glu Ile Leu Met Ala  Lys Asn Glu Asn Asn  Ser His Ala 
    1025                 1030                 1035             


Phe Ile  Arg Lys Met Val Glu  Asn Ile Lys Gln Thr  Lys Asp Ala 
    1040                 1045                 1050             


Gln Gly  Pro Asp Asp Ala Lys  Met Asn Glu Lys Leu  Tyr Thr Val 
    1055                 1060                 1065             


Cys Asp  Val Ala Met Asn Ile  Ile Met Ser Lys Ser  Thr Thr Tyr 
    1070                 1075                 1080             


Ser Leu  Glu Ser Pro Lys Asp  Pro Val Leu Pro Ala  Arg Phe Phe 
    1085                 1090                 1095             


Thr Gln  Pro Asp Lys Asn Phe  Ser Asn Thr Lys Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Pro Gly  Met Lys Ser Phe Phe  Thr Pro Gly Lys Pro  Lys Thr Thr 
    1115                 1120                 1125             


Asn Val  Leu Gly Ala Val Asn  Lys Pro Leu Ser Ser  Ala Gly Lys 
    1130                 1135                 1140             


Gln Ser  Gln Thr Lys Ser Ser  Arg Met Glu Thr Val  Gly Asn Ala 
    1145                 1150                 1155             


Ser Ser  Ser Ser Asn Pro Ser  Ser Pro Gly Arg Ile  Lys Gly Arg 
    1160                 1165                 1170             


Leu Asp  Ser Ser Glu Met Asp  His Ser Glu Asn Glu  Asp Tyr Thr 
    1175                 1180                 1185             


Met Ser  Ser Pro Leu Pro Gly  Lys Arg Ser Asp Lys  Arg Asp Asp 
    1190                 1195                 1200             


Ser Asp  Leu Val Arg Ser Glu  Leu Glu Lys Pro Arg  Gly Arg Lys 
    1205                 1210                 1215             


Lys Thr  Pro Val Thr Glu Arg  Glu Glu Lys Leu Gly  Met Asp Asp 
    1220                 1225                 1230             


Leu Thr  Lys Leu Val Gln Glu  Gln Arg Pro Lys Gly  Ser Gln Arg 
    1235                 1240                 1245             


Ser Arg  Lys Arg Gly His Thr  Ala Ser Glu Ser Asp  Glu Gln Gln 
    1250                 1255                 1260             


Trp Pro  Glu Glu Lys Arg Leu  Lys Glu Asp Ile Leu  Glu Asn Glu 
    1265                 1270                 1275             


Asp Glu  Gln Asn Ser Pro Pro  Lys Lys Gly Lys Arg  Gly Arg Pro 
    1280                 1285                 1290             


Pro Lys  Pro Leu Gly Gly Gly  Thr Pro Lys Glu Glu  Pro Thr Met 
    1295                 1300                 1305             


Lys Thr  Ser Lys Lys Gly Ser  Lys Lys Lys Ser Gly  Pro Pro Ala 
    1310                 1315                 1320             


Pro Glu  Glu Glu Glu Glu Glu  Glu Arg Gln Ser Gly  Asn Thr Glu 
    1325                 1330                 1335             


Gln Lys  Ser Lys Ser Lys Gln  His Arg Val Ser Arg  Arg Ala Gln 
    1340                 1345                 1350             


Gln Arg  Ala Glu Ser Ser Glu  Ser Ser Ala Ile Glu  Ser Thr Gln 
    1355                 1360                 1365             


Ser Thr  Pro Gln Lys Gly Arg  Gly Arg Pro Ser Lys  Thr Pro Ser 
    1370                 1375                 1380             


Pro Ser  Gln Pro Lys Lys Asn  Val 
    1385                 1390     


<210>  961
<211>  5347
<212>  DNA
<213>  Homosapiens

<400>  961
cccgcccgcg ggcaccatga cagctctgag cgctggggtt acagactgtg gttttgtgct     60

tgctcaccaa agctaacctc agcatgctca aaaggaagca gagttccagg gtggaagccc    120

agccagtcac tgactttggt cctgatgagt ctctgtcgga taatgctgac atcctctgga    180

ttaacaaacc atgggttcac tctttgctgc gcatctgtgc catcatcagc gtcatttctg    240

tttgtatgaa tacgccaatg accttcgagc actatcctcc acttcagtat gtgaccttca    300

ctttggatac attattgatg tttctctaca cggcagagat gatagcaaaa atgcacatcc    360

ggggcattgt caagggggat agttcctatg tgaaagatcg ctggtgtgtt tttgatggat    420

ttatggtctt ttgcctttgg gtttctttgg tgctacaggt gtttgaaatt gctgatatag    480

ttgatcagat gtcaccttgg ggcatgttgc ggattccacg gccactgatt atgatccgag    540

cattccggat ttatttccga tttgaactgc caaggaccag aattacaaat attttaaagc    600

gatcgggaga acaaatatgg agtgtttcca tttttctact tttctttcta cttctttatg    660

gaattttagg agttcagatg tttggaacat ttacttatca ctgtgttgta aatgacacaa    720

agccagggaa tgtaacctgg aatagtttag ctattccaga cacacactgc tcaccagagc    780

tagaagaagg ctaccagtgc ccacctggat ttaaatgcat ggaccttgaa gatctgggac    840

ttagcaggca agagctgggc tacagtggct ttaatgagat aggaactagt atattcaccg    900

tctatgaggc cgcctcacag gaaggctggg tgttcctcat gtacagagca attgacagct    960

ttccccgttg gcgttcctac ttctatttca tcactctcat tttcttcctc gcctggcttg   1020

tgaagaacgt gtttattgct gttatcattg aaacatttgc agaaatcaga gtacagtttc   1080

aacaaatgtg gggatcgaga agcagcacta cctcaacagc caccacccag atgtttcatg   1140

aagatgctgc tggaggttgg cagctggtag ctgtggatgt caacaagccc cagggacgcg   1200

ccccagcctg cctccagaaa atgatgcggt catccgtttt ccacatgttc atcctgagca   1260

tggtgaccgt ggacgtgatc gtggcggcta gcaactacta caaaggagaa aacttcagga   1320

ggcagtacga cgagttctac ctggcggagg tggcttttac agtacttttt gatttggaag   1380

cacttctgaa gatatggtgt ttgggattta ctggatatat tagctcatct ctccacaaat   1440

tcgaactact actcgtaatt ggaactactc ttcatgtata cccagatctt tatcattcac   1500

aattcacgta ctttcaggtt ctccgagtag ttcggctgat taagatttca cctgcattag   1560

aagactttgt gtacaagata tttggtcctg gaaaaaagct tgggagtttg gttgtattta   1620

ctgccagcct cttgattgtt atgtcagcaa ttagtttgca gatgttctgc tttgttgaag   1680

aactggacag atttactacg tttccgaggg catttatgtc catgttccag atcctcaccc   1740

aggaaggatg ggtggacgta atggaccaaa ctctaaatgc tgtgggacat atgtgggcac   1800

ccgtggttgc catctatttc attctctatc atctttttgc cactctgatc ctcctgagtt   1860

tgtttgttgc tgttattttg gacaacttag aacttgatga agacctaaag aagcttaaac   1920

aattaaagca aagtgaagca aatgcggaca ccaaagaaaa gctcccttta cgcctgcgaa   1980

tctttgaaaa atttccaaac agacctcaaa tggtgaaaat ctcaaagctt ccttcagatt   2040

ttacagttcc taaaatcagg gagagtttta tgaagcagtt tattgaccgc cagcaacagg   2100

acacatgttg cctcctgaga agcctcccga ccacctcttc ctcctcctgc gaccactcca   2160

aacgctcagc aattgaggac aacaaataca tcgaccaaaa acttcgcaag tctgttttca   2220

gcatcagggc aaggaacctt ctggaaaagg agaccgcagt cactaaaatc ttaagagctt   2280

gcacccgaca gcgcatgctg agcggatcat ttgaggggca gcccgcaaag gagaggtcaa   2340

tcctcagcgt gcagcatcat atccgccaag agcgcaggtc actaagacat ggatcaaaca   2400

gccagaggat cagcagggga aaatctcttg aaactttgac tcaagatcat tccaatacag   2460

tgagatatag aaatgcacaa agagaagaca gtgaaataaa gatgattcag gaaaaaaagg   2520

agcaagcaga gatgaaaagg aaagtgcaag aagaggaact cagagagaac cacccatact   2580

tcgataagcc actgttcatt gtcgggcgag aacacaggtt cagaaacttt tgccgggtgg   2640

tggtccgagc acgcttcaac gcatctaaaa cagaccctgt cacaggagct gtgaaaaata   2700

caaagtacca tcaactttat gatttgctgg gattggtcac ttacctggac tgggtcatga   2760

tcatcgtaac catctgctct tgcatttcca tgatgtttga gtccccgttt cgaagagtca   2820

tgcatgcacc tactttgcag attgctgagt atgtgtttgt gatattcatg agcattgagc   2880

ttaatctgaa gattatggca gatggcttat ttttcactcc aactgctgtc atcagggact   2940

tcggtggagt aatggacata tttatatatc ttgtgagctt gatatttctt tgttggatgc   3000

ctcaaaatgt acctgctgaa tcgggagctc agcttctaat ggtccttcgg tgcctgagac   3060

ctctgcgcat attcaaactg gtgccccaga tgaggaaagt tgttcgagaa cttttcagcg   3120

gcttcaagga aatttttttg gtctccattc ttttgctgac attaatgctc gtttttgcaa   3180

gctttggagt tcagcttttt gctggaaaac tggccaagtg caatgatccc aacattatta   3240

gaagggaaga ttgcaatggc atattcagaa ttaatgtcag tgtgtcaaag aacttaaatt   3300

taaaattgag gcctggagag aaaaaacctg gattttgggt gccccgtgtt tgggcgaatc   3360

ctcggaactt taatttcgac aatgtgggaa acgctatgct ggcgttgttt gaagttctct   3420

ccttgaaagg ctgggtggaa gtgagagatg ttattattca tcgtgtgggg ccgatccatg   3480

gaatctatat tcatgttttt gtattcctgg gttgcatgat tggactgacc ctttttgttg   3540

gagtagttat tgctaatttc aatgaaaaca aggggacggc tttgctgacc gtcgatcaga   3600

gaagatggga agacctgaag agccgactga agatcgcaca gcctcttcat ctyccgcctc   3660

gcccggataa tgatggtttt agagctaaaa tgtatgacat aacccagcat ccatttttta   3720

agaggacaat cgcattactc gtcctggccc agtcggtgtt gctctctgtc aagtgggacg   3780

tcgaggaccc ggtgacygta cctttggcaa caatgtcagt tgttttcacc ttcatctttg   3840

ttctggaggt taccatgaag atcatagcaa tgtcgcctgc tggcttctgg caaagcagaa   3900

gaaaccgata cgatctcctg gtgacgtcgc ttggcgttgt atgggtggtg cttcactttg   3960

ccctcctgaa tgcatatact tacatgatgg gcgcttgtgt gattgtattt aggtttttct   4020

ccatctgtgg aaaacatgta acgctaaaga tgctcctctt gacagtggtc gtcagcatgt   4080

acaagagctt ctttatcata gtaggcatgt ttctcttgct gctgtgttac gcttttgctg   4140

gagttgtttt atttggtact gtgaaatatg gggagaatat taacaggcat gcaaattttt   4200

cttcggctgg aaaagctatt accgtactgt tccgaattgt cacaggtgaa gactggaaca   4260

agattatgca tgactgtatg gttcagcctc cgttttgtac tccagatgaa tttacatact   4320

gggcaacaga ctgtggaaat tatgctgggg cacttatgta tttctgttca ttttatgtca   4380

tcattgccta catcatgcta aatctgcttg tagccataat tgtggagaat ttctccttgt   4440

tttattccac tgaggaggac cagcttttaa gttacaatga tcttcgccac tttcaaataa   4500

tatggaacat ggtggatgat aaaagagagg gggtgatccc cacgttccgc gtcaagttcc   4560

tgctgcggct actgcgtggg aggctggagg tggacctgga caaggacaag ctcctgttta   4620

agcacatgtg ctacgaaatg gagaggctcc acaatggcgg cgacgtcacc ttccatgatg   4680

tcctgagcat gctttcatac cggtccgtgg acatccggaa gagcttgcag ctggaggaac   4740

tcctggcgag ggagcagctg gagtacacca tagaggagga ggtggccaag cagaccatcc   4800

gcatgtggct caagaagtgc ctgaagcgca tcagagctaa acagcagcag tcgtgcagta   4860

tcatccacag cctgagagag agtcagcagc aagagctgag ccggtttctg aacccgccca   4920

gcatcgagac cacccagccc agtgaggaca cgaatgccaa cagtcaggac aacagcatgc   4980

aacctgagac aagcagccag cagcagctcc tgagccccac gctgtcggat cgaggaggaa   5040

gtcggcaaga tgcagccgac gcagggaaac cccagaggaa atttgggcag tggcgtctgc   5100

cctcagcccc aaaaccaata agccattcag tgtcctcagt caacttacgg tttggaggaa   5160

ggacaaccat gaaatctgtc gtgtgcaaaa tgaaccccat gactgacgcg gcttcctgcg   5220

gttctgaagt taagaagtgg tggacccggc agctgactgt ggagagcgac gaaagtgggg   5280

atgaccttct ggatatttag gtggatgtca atgtagatga atttctagtg gtggaaaccg   5340

ttttcta                                                             5347


<210>  962
<211>  1738
<212>  PRT
<213>  Homosapiens

<400>  962

Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr 
1               5                   10                  15      


Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp 
            20                  25                  30          


Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile 
        35                  40                  45              


Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr 
    50                  55                  60                  


Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe 
65                  70                  75                  80  


Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val 
                85                  90                  95      


Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly 
            100                 105                 110         


Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu 
        115                 120                 125             


Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile 
    130                 135                 140                 


Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe 
145                 150                 155                 160 


Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu 
                165                 170                 175     


Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr 
            180                 185                 190         


Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val 
        195                 200                 205             


Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile 
    210                 215                 220                 


Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro 
225                 230                 235                 240 


Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln 
                245                 250                 255     


Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr 
            260                 265                 270         


Val Tyr Glu Ala Ala Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg 
        275                 280                 285             


Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr 
    290                 295                 300                 


Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val 
305                 310                 315                 320 


Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp 
                325                 330                 335     


Gly Ser Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His 
            340                 345                 350         


Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys 
        355                 360                 365             


Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser 
    370                 375                 380                 


Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val 
385                 390                 395                 400 


Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp 
                405                 410                 415     


Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu 
            420                 425                 430         


Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser 
        435                 440                 445             


Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His 
    450                 455                 460                 


Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu 
465                 470                 475                 480 


Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val 
                485                 490                 495     


Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe 
            500                 505                 510         


Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe 
        515                 520                 525             


Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe 
    530                 535                 540                 


Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met 
545                 550                 555                 560 


Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val Ala 
                565                 570                 575     


Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser 
            580                 585                 590         


Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu 
        595                 600                 605             


Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys 
    610                 615                 620                 


Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg 
625                 630                 635                 640 


Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro 
                645                 650                 655     


Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln 
            660                 665                 670         


Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser Ser 
        675                 680                 685             


Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile Asp 
    690                 695                 700                 


Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu 
705                 710                 715                 720 


Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln 
                725                 730                 735     


Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser 
            740                 745                 750         


Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg 
        755                 760                 765             


His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr 
    770                 775                 780                 


Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg 
785                 790                 795                 800 


Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu 
                805                 810                 815     


Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr 
            820                 825                 830         


Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn 
        835                 840                 845             


Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp 
    850                 855                 860                 


Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp 
865                 870                 875                 880 


Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val Thr 
                885                 890                 895     


Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val 
            900                 905                 910         


Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe 
        915                 920                 925             


Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe 
    930                 935                 940                 


Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe 
945                 950                 955                 960 


Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val 
                965                 970                 975     


Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg 
            980                 985                 990         


Pro Leu Arg Ile Phe Lys Leu Val  Pro Gln Met Arg Lys  Val Val Arg 
        995                 1000                 1005             


Glu Leu  Phe Ser Gly Phe Lys  Glu Ile Phe Leu Val  Ser Ile Leu 
    1010                 1015                 1020             


Leu Leu  Thr Leu Met Leu Val  Phe Ala Ser Phe Gly  Val Gln Leu 
    1025                 1030                 1035             


Phe Ala  Gly Lys Leu Ala Lys  Cys Asn Asp Pro Asn  Ile Ile Arg 
    1040                 1045                 1050             


Arg Glu  Asp Cys Asn Gly Ile  Phe Arg Ile Asn Val  Ser Val Ser 
    1055                 1060                 1065             


Lys Asn  Leu Asn Leu Lys Leu  Arg Pro Gly Glu Lys  Lys Pro Gly 
    1070                 1075                 1080             


Phe Trp  Val Pro Arg Val Trp  Ala Asn Pro Arg Asn  Phe Asn Phe 
    1085                 1090                 1095             


Asp Asn  Val Gly Asn Ala Met  Leu Ala Leu Phe Glu  Val Leu Ser 
    1100                 1105                 1110             


Leu Lys  Gly Trp Val Glu Val  Arg Asp Val Ile Ile  His Arg Val 
    1115                 1120                 1125             


Gly Pro  Ile His Gly Ile Tyr  Ile His Val Phe Val  Phe Leu Gly 
    1130                 1135                 1140             


Cys Met  Ile Gly Leu Thr Leu  Phe Val Gly Val Val  Ile Ala Asn 
    1145                 1150                 1155             


Phe Asn  Glu Asn Lys Gly Thr  Ala Leu Leu Thr Val  Asp Gln Arg 
    1160                 1165                 1170             


Arg Trp  Glu Asp Leu Lys Ser  Arg Leu Lys Ile Ala  Gln Pro Leu 
    1175                 1180                 1185             


His Leu  Pro Pro Arg Pro Asp  Asn Asp Gly Phe Arg  Ala Lys Met 
    1190                 1195                 1200             


Tyr Asp  Ile Thr Gln His Pro  Phe Phe Lys Arg Thr  Ile Ala Leu 
    1205                 1210                 1215             


Leu Val  Leu Ala Gln Ser Val  Leu Leu Ser Val Lys  Trp Asp Val 
    1220                 1225                 1230             


Glu Asp  Pro Val Thr Val Pro  Leu Ala Thr Met Ser  Val Val Phe 
    1235                 1240                 1245             


Thr Phe  Ile Phe Val Leu Glu  Val Thr Met Lys Ile  Ile Ala Met 
    1250                 1255                 1260             


Ser Pro  Ala Gly Phe Trp Gln  Ser Arg Arg Asn Arg  Tyr Asp Leu 
    1265                 1270                 1275             


Leu Val  Thr Ser Leu Gly Val  Val Trp Val Val Leu  His Phe Ala 
    1280                 1285                 1290             


Leu Leu  Asn Ala Tyr Thr Tyr  Met Met Gly Ala Cys  Val Ile Val 
    1295                 1300                 1305             


Phe Arg  Phe Phe Ser Ile Cys  Gly Lys His Val Thr  Leu Lys Met 
    1310                 1315                 1320             


Leu Leu  Leu Thr Val Val Val  Ser Met Tyr Lys Ser  Phe Phe Ile 
    1325                 1330                 1335             


Ile Val  Gly Met Phe Leu Leu  Leu Leu Cys Tyr Ala  Phe Ala Gly 
    1340                 1345                 1350             


Val Val  Leu Phe Gly Thr Val  Lys Tyr Gly Glu Asn  Ile Asn Arg 
    1355                 1360                 1365             


His Ala  Asn Phe Ser Ser Ala  Gly Lys Ala Ile Thr  Val Leu Phe 
    1370                 1375                 1380             


Arg Ile  Val Thr Gly Glu Asp  Trp Asn Lys Ile Met  His Asp Cys 
    1385                 1390                 1395             


Met Val  Gln Pro Pro Phe Cys  Thr Pro Asp Glu Phe  Thr Tyr Trp 
    1400                 1405                 1410             


Ala Thr  Asp Cys Gly Asn Tyr  Ala Gly Ala Leu Met  Tyr Phe Cys 
    1415                 1420                 1425             


Ser Phe  Tyr Val Ile Ile Ala  Tyr Ile Met Leu Asn  Leu Leu Val 
    1430                 1435                 1440             


Ala Ile  Ile Val Glu Asn Phe  Ser Leu Phe Tyr Ser  Thr Glu Glu 
    1445                 1450                 1455             


Asp Gln  Leu Leu Ser Tyr Asn  Asp Leu Arg His Phe  Gln Ile Ile 
    1460                 1465                 1470             


Trp Asn  Met Val Asp Asp Lys  Arg Glu Gly Val Ile  Pro Thr Phe 
    1475                 1480                 1485             


Arg Val  Lys Phe Leu Leu Arg  Leu Leu Arg Gly Arg  Leu Glu Val 
    1490                 1495                 1500             


Asp Leu  Asp Lys Asp Lys Leu  Leu Phe Lys His Met  Cys Tyr Glu 
    1505                 1510                 1515             


Met Glu  Arg Leu His Asn Gly  Gly Asp Val Thr Phe  His Asp Val 
    1520                 1525                 1530             


Leu Ser  Met Leu Ser Tyr Arg  Ser Val Asp Ile Arg  Lys Ser Leu 
    1535                 1540                 1545             


Gln Leu  Glu Glu Leu Leu Ala  Arg Glu Gln Leu Glu  Tyr Thr Ile 
    1550                 1555                 1560             


Glu Glu  Glu Val Ala Lys Gln  Thr Ile Arg Met Trp  Leu Lys Lys 
    1565                 1570                 1575             


Cys Leu  Lys Arg Ile Arg Ala  Lys Gln Gln Gln Ser  Cys Ser Ile 
    1580                 1585                 1590             


Ile His  Ser Leu Arg Glu Ser  Gln Gln Gln Glu Leu  Ser Arg Phe 
    1595                 1600                 1605             


Leu Asn  Pro Pro Ser Ile Glu  Thr Thr Gln Pro Ser  Glu Asp Thr 
    1610                 1615                 1620             


Asn Ala  Asn Ser Gln Asp Asn  Ser Met Gln Pro Glu  Thr Ser Ser 
    1625                 1630                 1635             


Gln Gln  Gln Leu Leu Ser Pro  Thr Leu Ser Asp Arg  Gly Gly Ser 
    1640                 1645                 1650             


Arg Gln  Asp Ala Ala Asp Ala  Gly Lys Pro Gln Arg  Lys Phe Gly 
    1655                 1660                 1665             


Gln Trp  Arg Leu Pro Ser Ala  Pro Lys Pro Ile Ser  His Ser Val 
    1670                 1675                 1680             


Ser Ser  Val Asn Leu Arg Phe  Gly Gly Arg Thr Thr  Met Lys Ser 
    1685                 1690                 1695             


Val Val  Cys Lys Met Asn Pro  Met Thr Asp Ala Ala  Ser Cys Gly 
    1700                 1705                 1710             


Ser Glu  Val Lys Lys Trp Trp  Thr Arg Gln Leu Thr  Val Glu Ser 
    1715                 1720                 1725             


Asp Glu  Ser Gly Asp Asp Leu  Leu Asp Ile 
    1730                 1735             


<210>  963
<211>  4061
<212>  DNA
<213>  Homosapiens

<400>  963
cccacgcgtc cgcggctctc tttctcctct ctgtcctgct gtcgcctcct ctcctcactc     60

cagcctcctt ccctggctta ttctgcccag gaaagtttgg aacccccgcc ccccctcccc    120

aatcaggtca acctgactag gagtaggggg agatgtagga aggcctgaga gttcgggggg    180

gggaagctgg aagctggttt cccagaaaat ttccccccat cttctccatt tagggtggtg    240

ggaatttttt ttaatcctgt ttttgaggag gtggtaggtg tttagaaaag gatgtgggaa    300

tggaaggggt agatgagtca accctctttc aagattccaa gggtggtgtg ttacctgatc    360

cttttcgtgt gtggagttca gggggtcggg aggttggcct ttattcccac attcaaagtt    420

ggaacctccc ccaaattaag aatggagttt tagtacccac ttgtggcagg aatcctgggg    480

ggaaggggtc cttttttcct ttttcttttc ttttttccct ttttttcctt ttggcaaccc    540

acacccttcc acacacgctc accccaaaat taaacaccaa gatcctctaa cttgtttgga    600

ttgactgatg aagacataaa gctctatgtt ttttgaggtg gagtgagtgg tttttcttca    660

tttttaaatg gccaaatgac agcttgaccc agtttgcttt ccaatcaaag ggcatttatt    720

ttgaatgtct ctttgtggcg caagagccaa cgcaaaaatg atggcggctt acaatggcgg    780

tacatctgca gcagcaacag gtcaccacca ccaccatcac caccaccttc cacacctccc    840

tcctcctcac ctgcaccacc accaccaccc tcaacaccat cttcatccgg ggtcggctgc    900

cgctgtacac cctgtacagc agcacacctc ttcggcagct gcggcagccg cagcagcggc    960

tgcagctgca gccatgttaa accctgggca acaacagcca tatttcccat caccggcacc   1020

ggggcaggct cctggaccag ctgcagcagc cccagctcag gtacaggctg ccgcagctgc   1080

tacagttaag gcgcaccatc atcagcactc gcatcatcca cagcagcagc tggatattga   1140

gccggataga cctattggat atggagcctt tggtgttgtc tggtcagtaa cagatccaag   1200

agatggaaag agagtagcgc tcaaaaagat gcccaacgtc ttccagaatc tggtctcttg   1260

caaaagggtc ttccgggaat tgaagatgtt gtgttttttt aagcatgata atgtactctc   1320

tgcccttgac atactccaac ctccacacat tgactatttt gaagaaatat atgttgtcac   1380

agaattgatg cagagtgacc tacataaaat tatcgtctct cctcaaccac tcagctcaga   1440

tcatgtcaaa gtttttcttt atcagatttt gcgaggtttg aaatatctcc attcagctgg   1500

cattttacat cgagacatta agccagggaa tctccttgtg aacagcaact gtgttctaaa   1560

gatttgtgat tttggattgg ccagagtgga agaattagat gaatcccgtc atatgactca   1620

ggaagttgtt actcagtatt atcgggctcc agaaatcctg atgggcagcc gtcattacag   1680

caatgctatt gacatctggt ctgtgggatg tatctttgca gaactactag gacgaagaat   1740

attgtttcag gcacagagtc ccattcagca gttggatttg atcacggatc tgttgggcac   1800

accatcactg gaagcaatga ggacagcttg tgaaggcgct aaggcacata tactcagggg   1860

tcctcataaa cagccatctc ttcctgtact ctataccctg tctagccagg ctacacatga   1920

agctgttcat ctcctttgca ggatgttggt ctttgatcca tccaaaagaa tatccgctaa   1980

ggatgcctta gcccacccct acctagatga agggcgacta cgatatcaca catgtatgtg   2040

taaatgttgc ttttccacct ccactggaag agtttatacc agtgactttg agcctgtcac   2100

caatcccaaa tttgatgaca ctttcgagaa gaacctcagt tctgtccgac aggttaaaga   2160

aattattcat cagttcattt tggaacagca gaaaggaaac agagtgcctc tctgcatcaa   2220

ccctcagtct gctgctttta agagctttat tagttccact gttgctcagc catctgagat   2280

gcccccatct cctctggtgt gggagtgatg gtggaagata atgtactact gaagatgtaa   2340

tgtagctttc cactggagtc tgggatttgc aattctggag gttaatcatg cttgtactgt   2400

aattttacta atgaagtttt aaattaacaa ccactacttg tatgatatga ataatattta   2460

gaaatgttac tagactttta atcttgtaaa gtggttgtgc ttttagaaga aaaatatttt   2520

acccagagtt gcacatgttt tatgaattta gtgcagctgt tatggctcac ctcagaacaa   2580

aagagaattg aaccaaattt gggagtttgg ggttttatgt tttgtttttc ttttctaaaa   2640

tgaagtgaga ttgttcacac acacacacac acacacacac acacaaacac aaaggacagt   2700

catacatttt gatatttgag ccattcctaa agatttgggg ttttctaaaa ctaaagaatc   2760

taggaacctt gcctgcgacc aatcatggag ccacgtgagc tgatcgtggc tgcacctggg   2820

gggagggtag ggaggagggg catgccacct aatgatcaag ccctataatt agcttctcat   2880

tagagccgtg atggtgatgt gtgctgtcta aaatccaatg ttgtgggtag agagaatgag   2940

tttgtgacta ggagagacta aacttttgtt ttccttaccc agtataaata tatatatata   3000

tatttaatct atttttatta gaagtttttc tgctctttct tacataaaag aaccccaagc   3060

atgcatcttt catgtgtgta aataattcat ttctgggcta atttcaaaag aatcccaata   3120

ttgctgtata gaaagagaac tagcttgcac attttaggtc tgtgaaattt tgtgagactt   3180

ttcctgcact ggacagtaaa aaaataataa aagacaaaaa caaatttaaa aaaaaattta   3240

agccacaaaa aaaggcacat agggaattat gtcaaatgtg tttgtgtcct taggcaaagc   3300

tgtgggagtc ttgaaatgtc acagtagtaa ataacttatt actttttgac aagttctttt   3360

tttctgttgg aacactgaat tcttctgtgc atatgtacat atgaatacaa atcgaaggcc   3420

tctacctcct ggagttatac aacttggctt gtttacctcc acatgctgat gatgactatt   3480

tttttttttg agttcagtgt ggagacttga aacttgaatg tcccttccaa cttttatatt   3540

aaaaataaaa agacaagaaa attgaagatc atttttcacc tgtacaagga atactaatgg   3600

atcgtcttaa aattggtcta ggaaaaaacc ttggtgtgtg ttatggacaa ttaactgtta   3660

aagttattgt aagttatctg tatttagcag agtattttca acttgagtga tctgagctga   3720

atttgaagac tattaataag ttatgtttgg aagttttaac ttcaatgaag taattatttg   3780

ctgtgaaaga aacaaacatt gaattactaa acaaagatgg tgcaatatct ttgttttttt   3840

tttatgaggc tcctgagaat caacccaact gaagcatttc aattcacttg aatgagaaac   3900

gtgtttagta tcaaaagagc ccaagaagac actggtgtga aaggtacaat ctcagaggtt   3960

ggtcaattac cgtggcacac tttctggtca ctttgtacaa tgtagatttg aagtacagtg   4020

gtgaaaacat taaatgtgac atttgaaaaa aaaaaaaaaa a                       4061


<210>  964
<211>  515
<212>  PRT
<213>  Homosapiens

<400>  964

Met Ala Ala Tyr Asn Gly Gly Thr Ser Ala Ala Ala Thr Gly His His 
1               5                   10                  15      


His His His His His His Leu Pro His Leu Pro Pro Pro His Leu His 
            20                  25                  30          


His His His His Pro Gln His His Leu His Pro Gly Ser Ala Ala Ala 
        35                  40                  45              


Val His Pro Val Gln Gln His Thr Ser Ser Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Met Leu Asn Pro Gly Gln Gln Gln Pro 
65                  70                  75                  80  


Tyr Phe Pro Ser Pro Ala Pro Gly Gln Ala Pro Gly Pro Ala Ala Ala 
                85                  90                  95      


Ala Pro Ala Gln Val Gln Ala Ala Ala Ala Ala Thr Val Lys Ala His 
            100                 105                 110         


His His Gln His Ser His His Pro Gln Gln Gln Leu Asp Ile Glu Pro 
        115                 120                 125             


Asp Arg Pro Ile Gly Tyr Gly Ala Phe Gly Val Val Trp Ser Val Thr 
    130                 135                 140                 


Asp Pro Arg Asp Gly Lys Arg Val Ala Leu Lys Lys Met Pro Asn Val 
145                 150                 155                 160 


Phe Gln Asn Leu Val Ser Cys Lys Arg Val Phe Arg Glu Leu Lys Met 
                165                 170                 175     


Leu Cys Phe Phe Lys His Asp Asn Val Leu Ser Ala Leu Asp Ile Leu 
            180                 185                 190         


Gln Pro Pro His Ile Asp Tyr Phe Glu Glu Ile Tyr Val Val Thr Glu 
        195                 200                 205             


Leu Met Gln Ser Asp Leu His Lys Ile Ile Val Ser Pro Gln Pro Leu 
    210                 215                 220                 


Ser Ser Asp His Val Lys Val Phe Leu Tyr Gln Ile Leu Arg Gly Leu 
225                 230                 235                 240 


Lys Tyr Leu His Ser Ala Gly Ile Leu His Arg Asp Ile Lys Pro Gly 
                245                 250                 255     


Asn Leu Leu Val Asn Ser Asn Cys Val Leu Lys Ile Cys Asp Phe Gly 
            260                 265                 270         


Leu Ala Arg Val Glu Glu Leu Asp Glu Ser Arg His Met Thr Gln Glu 
        275                 280                 285             


Val Val Thr Gln Tyr Tyr Arg Ala Pro Glu Ile Leu Met Gly Ser Arg 
    290                 295                 300                 


His Tyr Ser Asn Ala Ile Asp Ile Trp Ser Val Gly Cys Ile Phe Ala 
305                 310                 315                 320 


Glu Leu Leu Gly Arg Arg Ile Leu Phe Gln Ala Gln Ser Pro Ile Gln 
                325                 330                 335     


Gln Leu Asp Leu Ile Thr Asp Leu Leu Gly Thr Pro Ser Leu Glu Ala 
            340                 345                 350         


Met Arg Thr Ala Cys Glu Gly Ala Lys Ala His Ile Leu Arg Gly Pro 
        355                 360                 365             


His Lys Gln Pro Ser Leu Pro Val Leu Tyr Thr Leu Ser Ser Gln Ala 
    370                 375                 380                 


Thr His Glu Ala Val His Leu Leu Cys Arg Met Leu Val Phe Asp Pro 
385                 390                 395                 400 


Ser Lys Arg Ile Ser Ala Lys Asp Ala Leu Ala His Pro Tyr Leu Asp 
                405                 410                 415     


Glu Gly Arg Leu Arg Tyr His Thr Cys Met Cys Lys Cys Cys Phe Ser 
            420                 425                 430         


Thr Ser Thr Gly Arg Val Tyr Thr Ser Asp Phe Glu Pro Val Thr Asn 
        435                 440                 445             


Pro Lys Phe Asp Asp Thr Phe Glu Lys Asn Leu Ser Ser Val Arg Gln 
    450                 455                 460                 


Val Lys Glu Ile Ile His Gln Phe Ile Leu Glu Gln Gln Lys Gly Asn 
465                 470                 475                 480 


Arg Val Pro Leu Cys Ile Asn Pro Gln Ser Ala Ala Phe Lys Ser Phe 
                485                 490                 495     


Ile Ser Ser Thr Val Ala Gln Pro Ser Glu Met Pro Pro Ser Pro Leu 
            500                 505                 510         


Val Trp Glu 
        515 


<210>  965
<211>  840
<212>  DNA
<213>  Homosapiens

<400>  965
ccagtgcgcc cttgaaactt tcctcgcctt ccacctcctg ctcatctgct tcacaagctg     60

tcgctgtggt gtcggttcgc aggtcgtggc ctctcatggc cacggtgctt ttggccctgc    120

tcgtctacct gggggcgctg gtcgacgcct accccatcaa acccgaggct cccggcgaag    180

acgccttcct ggggtagctg agccgctgct acgcctatcc tcgccactac ctcatcctgg    240

tcactcagcc gtcgtgagcg caggcgcggg gcgggcggac ggggacccct ggggctctcc    300

ccctacagcc ccgctccacc gggggcgtgg ctagatctga ccgcgcccgg ccaggccccg    360

ccctcaggta tgggaaacta ggccgcccag tcgcgcgcct ctccaaaacg ttcttcccag    420

actgcgagga ccgcctcggc aggtggcggt aaaagcgccc ccatcaagtc acataacatc    480

ctgcctccga gagcgcggtc tggccccacc ctggtccatc atcacttacg acgtctccca    540

ggcttgcctc cccggatcgg attcctttcc cttcgatccc gcaggccgga gggcgcagac    600

ctgtggtgag gacacccgag gcctcctggg agacctgcag accacgccca cctcatttac    660

atgttcactc ccgaccctgg aaacccggat ttcgcctccg gacagcggcg tctgggcagg    720

gttcgggtac tgcagtcccg cgtctggatg ccccgcgccc cctgagctgc agggctgtgt    780

gtggtccttc cctggtccca aaataaagag cggattgcac agaaacggaa aaaaaaaaaa    840


<210>  966
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  966

Met Ala Thr Val Leu Leu Ala Leu Leu Val Tyr Leu Gly Ala Leu Val 
1               5                   10                  15      


Asp Ala Tyr Pro Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Phe Leu 
            20                  25                  30          


Gly 
    


<210>  967
<211>  2445
<212>  DNA
<213>  Homosapiens

<400>  967
atgaactcag atgagcaagc tggactttct caattccttc tagagcctga aactcaaaac     60

ccagagaccc ttgaagagat ccagtcctct tagcaccagc aagaagcccc agcacagctt    120

ccacagctcc ctgaggagga acaggctgcc tctctgcctc cagagcaccc caaggaggtc    180

aactcttcct cagcccaatt aaaggcccca gctcagacaa cagagttccc tgaggagatg    240

aaaccttctg caactcagca agggactcca gctgagcctc caggtcctcc tgtggaggtt    300

gaaccttccc ccagtgagca ggagcagcca gttcagcctt ttaaacctgc ggatgtggat    360

attgccataa cttcagagtc tgccaagaag actgaatctt ctccagccca gcaggaggcc    420

ccaacccagt ctccagagga ggtggaaact tctgcaaccc aagaggaggc cacaactgat    480

cctccaggtc ctcctgtgga ggctgaccct tcccgcagtg agcaggaaca gccagcttag    540

ccctctgagt cttctgggga ggttgaatct tctccagcca agaaggagac cccagctcag    600

cctccagaac attatgaagt tacagtttca cctccaggtc accatcaagc tcagcattcc    660

ggtttgccca atgtcactgt taagcctcca gatatgcagc tcaccatagc aacagagcct    720

actgcagagg tgggaacttc tccagtctac caagagggta cagctcagct ctcagggcca    780

gttaatgatg tagaaccttc tgccacccag catgggggcc cacctctgcc tccagagtca    840

ttggaagagg ctgggccttt accagttcaa caggagactt cagttcagtc tccagaacct    900

attaaggatc agaacccctc tgcagcccag caggaggctg agcatccaca gacccctgag    960

gaggttgagt cttctctaac ccagcaggag gccccagctc agactccaga gctccttaat   1020

gaagttgtag ctcaatctcc agagcatcat gaggagaccc caactcagcc tcctaagaaa   1080

gttgtacccc aacttccagc atatcaagag gtaacagccg caacaccaga tcgggggctt   1140

accatcacgc ctgaatccac tacaaaggtt gaaccttcta cagccctgac gactacagct   1200

ccagctccaa aatgccgtga ggtgacattt ccacctccag acaaaggtca ggctcagcat   1260

tcaagcctga ctcaactcac aattccatcc cttaccataa ctacagagcc tactagaggg   1320

gagggccagg gaagtcgcat tgtgttggag gtgcagcacg cttatctgga cactagcctg   1380

acggggtggg aggtcttgac gccattccca ggattgggcg ctgcggtggc cccaacacgg   1440

ggtggggcca acctgaagca gtgtgacctg ctgatgctga agttttccca gcggcagaag   1500

cagctctgct ggagggaccc ctacctggct gagaccctgc gggacgctgc acacctgggc   1560

ctgctccagt ttcagtccca tcctgagttc catcctgagt tccagctccg tcgtgagcgc   1620

tggaactgta gcctagaggg caggatgggc ccgctcagga gaggtcatga cacaggggga   1680

ggaaaagaag gctgcgctgg aagtggaact ttagcgggaa agggggcatg gatccttagg   1740

aatataaagg gactcaggct gcccacggcg cggaacaccc gcaagctacc gtcagggatc   1800

gcgccgaccc cagccgtggg gtcacgtgac cgcccgcggc tctgtccgcc ctgccccctc   1860

cagacgcggg ctctgcgctg ctcatgcgct ctggtcgtgg ccggcctcgt gtgggtgctg   1920

ctgccgccgg agggcgccct gggcgagggg ctgcaggtgc cgcagcagtc cagggccgcc   1980

agctggctga atttaggctc gatcaagaac acaaagaaat ctaaaaacca caagaaaatt   2040

gcaaacgcca cgaacacctc cccaccgaaa gccacgaaac cccctccatg gaccaccacg   2100

aaaccccagt ggctgaacac ctcggaaccc cgaccaccaa cctcctgggg ccccaggacc   2160

tggttctact tccaggtcat ttgcacacac cagattgagt caggacttga ggggaaacac   2220

aattgtggag tcacttccat ggggtctgtg caaggcttgg tcagcatgtt gatgtatcta   2280

cggagctcag ctgtgtactg ggccatctgc tccggtgtgg tattgtcccc tgggtacaat   2340

ggctccaacg gggctccccg ggcacccagc agtggctaca gcaacagagc cacacaggtg   2400

gacaggagca ggagggagag gcagcggcat gcggcagcca tctga                   2445


<210>  968
<211>  814
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  Xaa can be any naturally occurring amino acid

<400>  968

Met Asn Ser Asp Glu Gln Ala Gly Leu Ser Gln Phe Leu Leu Glu Pro 
1               5                   10                  15      


Glu Thr Gln Asn Pro Glu Thr Leu Glu Glu Ile Gln Ser Ser Xaa His 
            20                  25                  30          


Gln Gln Glu Ala Pro Ala Gln Leu Pro Gln Leu Pro Glu Glu Glu Gln 
        35                  40                  45              


Ala Ala Ser Leu Pro Pro Glu His Pro Lys Glu Val Asn Ser Ser Ser 
    50                  55                  60                  


Ala Gln Leu Lys Ala Pro Ala Gln Thr Thr Glu Phe Pro Glu Glu Met 
65                  70                  75                  80  


Lys Pro Ser Ala Thr Gln Gln Gly Thr Pro Ala Glu Pro Pro Gly Pro 
                85                  90                  95      


Pro Val Glu Val Glu Pro Ser Pro Ser Glu Gln Glu Gln Pro Val Gln 
            100                 105                 110         


Pro Phe Lys Pro Ala Asp Val Asp Ile Ala Ile Thr Ser Glu Ser Ala 
        115                 120                 125             


Lys Lys Thr Glu Ser Ser Pro Ala Gln Gln Glu Ala Pro Thr Gln Ser 
    130                 135                 140                 


Pro Glu Glu Val Glu Thr Ser Ala Thr Gln Glu Glu Ala Thr Thr Asp 
145                 150                 155                 160 


Pro Pro Gly Pro Pro Val Glu Ala Asp Pro Ser Arg Ser Glu Gln Glu 
                165                 170                 175     


Gln Pro Ala Xaa Pro Ser Glu Ser Ser Gly Glu Val Glu Ser Ser Pro 
            180                 185                 190         


Ala Lys Lys Glu Thr Pro Ala Gln Pro Pro Glu His Tyr Glu Val Thr 
        195                 200                 205             


Val Ser Pro Pro Gly His His Gln Ala Gln His Ser Gly Leu Pro Asn 
    210                 215                 220                 


Val Thr Val Lys Pro Pro Asp Met Gln Leu Thr Ile Ala Thr Glu Pro 
225                 230                 235                 240 


Thr Ala Glu Val Gly Thr Ser Pro Val Tyr Gln Glu Gly Thr Ala Gln 
                245                 250                 255     


Leu Ser Gly Pro Val Asn Asp Val Glu Pro Ser Ala Thr Gln His Gly 
            260                 265                 270         


Gly Pro Pro Leu Pro Pro Glu Ser Leu Glu Glu Ala Gly Pro Leu Pro 
        275                 280                 285             


Val Gln Gln Glu Thr Ser Val Gln Ser Pro Glu Pro Ile Lys Asp Gln 
    290                 295                 300                 


Asn Pro Ser Ala Ala Gln Gln Glu Ala Glu His Pro Gln Thr Pro Glu 
305                 310                 315                 320 


Glu Val Glu Ser Ser Leu Thr Gln Gln Glu Ala Pro Ala Gln Thr Pro 
                325                 330                 335     


Glu Leu Leu Asn Glu Val Val Ala Gln Ser Pro Glu His His Glu Glu 
            340                 345                 350         


Thr Pro Thr Gln Pro Pro Lys Lys Val Val Pro Gln Leu Pro Ala Tyr 
        355                 360                 365             


Gln Glu Val Thr Ala Ala Thr Pro Asp Arg Gly Leu Thr Ile Thr Pro 
    370                 375                 380                 


Glu Ser Thr Thr Lys Val Glu Pro Ser Thr Ala Leu Thr Thr Thr Ala 
385                 390                 395                 400 


Pro Ala Pro Lys Cys Arg Glu Val Thr Phe Pro Pro Pro Asp Lys Gly 
                405                 410                 415     


Gln Ala Gln His Ser Ser Leu Thr Gln Leu Thr Ile Pro Ser Leu Thr 
            420                 425                 430         


Ile Thr Thr Glu Pro Thr Arg Gly Glu Gly Gln Gly Ser Arg Ile Val 
        435                 440                 445             


Leu Glu Val Gln His Ala Tyr Leu Asp Thr Ser Leu Thr Gly Trp Glu 
    450                 455                 460                 


Val Leu Thr Pro Phe Pro Gly Leu Gly Ala Ala Val Ala Pro Thr Arg 
465                 470                 475                 480 


Gly Gly Ala Asn Leu Lys Gln Cys Asp Leu Leu Met Leu Lys Phe Ser 
                485                 490                 495     


Gln Arg Gln Lys Gln Leu Cys Trp Arg Asp Pro Tyr Leu Ala Glu Thr 
            500                 505                 510         


Leu Arg Asp Ala Ala His Leu Gly Leu Leu Gln Phe Gln Ser His Pro 
        515                 520                 525             


Glu Phe His Pro Glu Phe Gln Leu Arg Arg Glu Arg Trp Asn Cys Ser 
    530                 535                 540                 


Leu Glu Gly Arg Met Gly Pro Leu Arg Arg Gly His Asp Thr Gly Gly 
545                 550                 555                 560 


Gly Lys Glu Gly Cys Ala Gly Ser Gly Thr Leu Ala Gly Lys Gly Ala 
                565                 570                 575     


Trp Ile Leu Arg Asn Ile Lys Gly Leu Arg Leu Pro Thr Ala Arg Asn 
            580                 585                 590         


Thr Arg Lys Leu Pro Ser Gly Ile Ala Pro Thr Pro Ala Val Gly Ser 
        595                 600                 605             


Arg Asp Arg Pro Arg Leu Cys Pro Pro Cys Pro Leu Gln Thr Arg Ala 
    610                 615                 620                 


Leu Arg Cys Ser Cys Ala Leu Val Val Ala Gly Leu Val Trp Val Leu 
625                 630                 635                 640 


Leu Pro Pro Glu Gly Ala Leu Gly Glu Gly Leu Gln Val Pro Gln Gln 
                645                 650                 655     


Ser Arg Ala Ala Ser Trp Leu Asn Leu Gly Ser Ile Lys Asn Thr Lys 
            660                 665                 670         


Lys Ser Lys Asn His Lys Lys Ile Ala Asn Ala Thr Asn Thr Ser Pro 
        675                 680                 685             


Pro Lys Ala Thr Lys Pro Pro Pro Trp Thr Thr Thr Lys Pro Gln Trp 
    690                 695                 700                 


Leu Asn Thr Ser Glu Pro Arg Pro Pro Thr Ser Trp Gly Pro Arg Thr 
705                 710                 715                 720 


Trp Phe Tyr Phe Gln Val Ile Cys Thr His Gln Ile Glu Ser Gly Leu 
                725                 730                 735     


Glu Gly Lys His Asn Cys Gly Val Thr Ser Met Gly Ser Val Gln Gly 
            740                 745                 750         


Leu Val Ser Met Leu Met Tyr Leu Arg Ser Ser Ala Val Tyr Trp Ala 
        755                 760                 765             


Ile Cys Ser Gly Val Val Leu Ser Pro Gly Tyr Asn Gly Ser Asn Gly 
    770                 775                 780                 


Ala Pro Arg Ala Pro Ser Ser Gly Tyr Ser Asn Arg Ala Thr Gln Val 
785                 790                 795                 800 


Asp Arg Ser Arg Arg Glu Arg Gln Arg His Ala Ala Ala Ile 
                805                 810                 


<210>  969
<211>  1951
<212>  DNA
<213>  Homosapiens

<400>  969
aagttaaggc ctttgtccgt tgaggtcagg actaggtggt ctcagccaat ggggacagag     60

cggtcacggg gaccgggttt gcgcggctcc gaggcctaac caggcagccg agcctgcctg    120

cgtcccgagg ccgccttccc gggacctctg caccctcagg tcctccgttg ggtggtgttc    180

gggcggccgc caggcttccc ggcccgccac tcccgctgcc acccaaaggc gctgcgtgcc    240

ggcggcttgg tggagtttcg tcgaggcccg gcaggcttgg gccaggagat ccagcggccg    300

ggcggggtcc cggctgagag aggccgatgc cgccgtcagt caccgagatg gggtggggac    360

gcttcaaggc ctgggtctgg ccagggggca gtcacagcag ggccctaggg taatcacttt    420

gatcaacatg acgaaggaca cttggaaact gaacaagcat cacttgacaa gcctacagaa    480

tccataagat ggatcattgc ttaatttcgg gtcttagcca gttagattta ccttcagctt    540

taacaaaaaa ttggccgtca aaacctgagt cctgtcctct tgccctcctc cccggacagc    600

atgaacttca ccacttgctc caccctctcc accaactacc agtccctggg cactgtccag    660

gcacccagct atgtgcccag ctggtcagca gtgtggccag tgtctatgca ggcatcaggg    720

gctctggttc ccggatctcc atgtcctgct tcaccagctt ccagggcagc atggggtcca    780

ggggcctgcc cgcagtgatg gccgggggtc tggcaggaat gggagtcatc cagaatgaga    840

aggaaaccat gcaaagcctc aacgaccacc tggcctccta cctggacaga gttaggagcc    900

tggataccaa gaactggaag ctggagagcc aggagcacct ggagaagaag ggaccccagg    960

tcagagactg gagccatgac ttcaagacca tcgagaacct gagggctcag atctttgcaa   1020

atactgtgga cagtgcccac attgttctgc agatcgacaa tgcctgtctt gctggtgatg   1080

actttagggt caagtatgag acagagctgg ccatgtgcca gtctgtggag agtgacatcc   1140

atgggctcca caaggtcatt gatgacacca atgtcacttg gctgcagctg gaagcagaga   1200

tcaaggctct caaggagaag ctgctcttca tgaagaagaa ccatgaagag gaagtaaagg   1260

gcctataagc ccagattgcc agctctgggt tgactgtgga ggtagatgcc cccaaatctc   1320

atgaccttgc caaaatcttg gcagacattg ggcccaatat gacgagctgg ctccgaagaa   1380

cttagaggag ctgggcaagt actggtctcc gcagattgag gagagcaccg cagttgtcac   1440

cacgcagtct gccgaggttg gagctgctga gatgacgctc acggagctga gacatacagt   1500

ccagtccttg gagatcgacc tggactccat gagcaatctg aaggccagct tggagaacag   1560

cctgagggag gtggaggcct gttacaccct gcggacggag cagctcaaca ggatcctgct   1620

gcacttggag tcagagctgg cacagacccg ggcagaggga cagcactagg cccaggagta   1680

tgaggccctg ctgaacatca aggtcaagct ggaggctgag atcgccacct accaccgcct   1740

gctggaagac agtgaggact tcaatctttc aatcttggtg atgccctgga cagcagcaac   1800

tccatgcaaa ccatccaaaa gactaccacc tgccggatat tggatggcaa agtggtgtct   1860

gagaccagtg atgccaaagt tctgatacct taagccagca gaagcagggg accctttggg   1920

gagcaggagg ccaataaaaa gttcagaggt t                                  1951


<210>  970
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  970

Met Asp His Cys Leu Ile Ser Gly Leu Ser Gln Leu Asp Leu Pro Ser 
1               5                   10                  15      


Ala Leu Thr Lys Asn Trp Pro Ser Lys Pro Glu Ser Cys Pro Leu Ala 
            20                  25                  30          


Leu Leu Pro Gly Gln His Glu Leu His His Leu Leu His Pro Leu His 
        35                  40                  45              


Gln Leu Pro Val Pro Gly His Cys Pro Gly Thr Gln Leu Cys Ala Gln 
    50                  55                  60                  


Leu Val Ser Ser Val Ala Ser Val Tyr Ala Gly Ile Arg Gly Ser Gly 
65                  70                  75                  80  


Ser Arg Ile Ser Met Ser Cys Phe Thr Ser Phe Gln Gly Ser Met Gly 
                85                  90                  95      


Ser Arg Gly Leu Pro Ala Val Met Ala Gly Gly Leu Ala Gly Met Gly 
            100                 105                 110         


Val Ile Gln Asn Glu Lys Glu Thr Met Gln Ser Leu Asn Asp His Leu 
        115                 120                 125             


Ala Ser Tyr Leu Asp Arg Val Arg Ser Leu Asp Thr Lys Asn Trp Lys 
    130                 135                 140                 


Leu Glu Ser Gln Glu His Leu Glu Lys Lys Gly Pro Gln Val Arg Asp 
145                 150                 155                 160 


Trp Ser His Asp Phe Lys Thr Ile Glu Asn Leu Arg Ala Gln Ile Phe 
                165                 170                 175     


Ala Asn Thr Val Asp Ser Ala His Ile Val Leu Gln Ile Asp Asn Ala 
            180                 185                 190         


Cys Leu Ala Gly Asp Asp Phe Arg Val Lys Tyr Glu Thr Glu Leu Ala 
        195                 200                 205             


Met Cys Gln Ser Val Glu Ser Asp Ile His Gly Leu His Lys Val Ile 
    210                 215                 220                 


Asp Asp Thr Asn Val Thr Trp Leu Gln Leu Glu Ala Glu Ile Lys Ala 
225                 230                 235                 240 


Leu Lys Glu Lys Leu Leu Phe Met Lys Lys Asn His Glu Glu Glu Val 
                245                 250                 255     


Lys Gly Leu 
            


<210>  971
<211>  2133
<212>  DNA
<213>  Homosapiens

<400>  971
tggggttcca gttgcctctc tcgggtcctg cccatgcctc ccccgctcct aacccaactt     60

tagttcggtg ttttcctcgg gctttgtctc tatcccagcc ccttctccca agcggcgggg    120

gcgaacgctt tgtttccttt aaagtcactt cttccctggg tttaaggttt cccgcgattc    180

cacctctggc cggttgtcag tgtctgaggg aagtagtctg gatgaagtgg tgtccaaagt    240

cacatgtcag catggatccg catccttttt atttgacaag tttagaaacc tgctgaagtg    300

gtatgctaag gagttcaaag acccactgct acaggagccc ccagcctggt ttaagtcctt    360

tctgttttgc gagcttgtgt ttcagctgcc tttctttccc attgcaacgt atgccttcct    420

caaaggaagc tgcaagtgga ttcgaactcc tgcaatcatc tactctgttc acaccatgac    480

aaccttaatt ccgatactct ccacatttct gtttgaggat ttctccaaag ccagtggttt    540

caagggacaa agacctgaga ctttgcatga acggttaacc cttgtgtctg tctatgcccc    600

ctacttactc atcccattca tacttttaat tttcatgttg cggagcccct actacaagta    660

tgaagagaaa agaaaaaaaa aatgaaggaa acaaccactg gcccagggta gagatgccta    720

cagggtggtt gcttgttgga tacaatacaa ggaacactgc tcagaaccca cgtcttcagc    780

agcatttgaa acactggcag caatgcacaa gagcaagatg gtgtcaggaa ccatgtcaaa    840

ccctcacctt cttccatttt tttttttttt tttaagacag tctcactctg ttgcccaggc    900

tggagtaaag ggcagtggca tgatctcggc tcactgcaac ctccgcctcc tgggctcaag    960

ccatcttcct tagcctccca agtagctaga actacaggtg tgtaccaaca cgtatggcta   1020

atttgttttg ttttttttgt gtgtgtggag acagggtttt gccatgttgc ccaggttggt   1080

ctcgaacgcc taggctcaag tgatctgccc acctcagtct ccctaagtgc tgggattaca   1140

gacgtgaacc actgggccca gcccaaacct tcaccttcta agggcactgg gatgaacgga   1200

ccgatcggct tgagggtggg caaaggggtg tgggctaggt tataaggaag tggtaccaaa   1260

taactgtgtg cctgagttcc accgcaagat tactaaaagc aggaccagac cagaaactgc   1320

taaagaacat ggcctgtttg acatgttcat gagtcacctg acccacagca tatatgcttg   1380

tgactaaacc ctccactcct gattctcaag agtgtatcac ctgtcagcaa aatgaatagt   1440

gggatatttt gggccatttt aaatgtgaaa ttttgcctct ttaatgttaa ttcaaaacta   1500

tatcaatgtt ttcttgttcc cacctctaac ccaaggaaaa aagagaaaac atactatgca   1560

aaggaagttt aaacttaagt tttccttaag ggtcagccca acaatgactt tcagtcaaat   1620

ggattaaact ggaaaatgtt tttgtttctg ttgtaaacag atcatcctag gcgaaagttt   1680

tttttgtttg tttgctttta aattagttta tttctaaatc ttagtcttcc acatttctag   1740

aggccacctg acacaagtcc ctgtatctga agtctagcat ctcaaggctg atctggaagt   1800

gtgctagtat gctccctagt ggataactta atcttttaat acagttccgt cattcccatc   1860

ttgttttcag aagagaaggt ggctacagcc aggcataaca tatccactgt gtgcatagag   1920

ggtctcttca cgttgatgct tggcattcca tcagctttct ctaagtcttt gctcaagttc   1980

aaccttaaaa tgatgttaga caacaggtcc cagtcagttc cctctatttt cacccatttt   2040

gctcacaagc catattggcc cgattagtgg tactgtctga ctcacgtgtg tgatccaaat   2100

aaaggtagct gctgaccaaa aaaaaaaaaa aaa                                2133


<210>  972
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  972

Met Thr Thr Leu Ile Pro Ile Leu Ser Thr Phe Leu Phe Glu Asp Phe 
1               5                   10                  15      


Ser Lys Ala Ser Gly Phe Lys Gly Gln Arg Pro Glu Thr Leu His Glu 
            20                  25                  30          


Arg Leu Thr Leu Val Ser Val Tyr Ala Pro Tyr Leu Leu Ile Pro Phe 
        35                  40                  45              


Ile Leu Leu Ile Phe Met Leu Arg Ser Pro Tyr Tyr Lys Tyr Glu Glu 
    50                  55                  60                  


Lys Arg Lys Lys Lys 
65                  


<210>  973
<211>  1016
<212>  DNA
<213>  Homosapiens

<400>  973
ggtaaacagg ctctgtatcc gtggcagcgg ccgtggcagg ctggctgggt accggctgtc     60

gctgacccag gagaagctgc ctgtctacat cagcctgggc tgcagcgcgc tgccgccgcg    120

gggccggcag ccatggccaa ggacatcctg ggtgaagcag ggctacactt tgatgaactg    180

aacaagctga gggtgttgga cccagaggtt acccagcaga ccatagagct gaaggaagag    240

tgcaaagact ttgtggacaa aattggccag tttcagaaaa tagttggtgg tttaattgag    300

cttgttgatc aacttgcaaa agaagcagaa aatgaaaaga tgaagagtct tgctgtgtca    360

cccaggctgg agtgcactgg tgcaatctcg gctcactgca agctctgcct ctcagattca    420

agcgattctc ccacctcacc ctcccgagta ggtgggacta caggccatcg gtgctcggaa    480

cttgctcaaa tctatagcaa agcagagaga agctcaacag cagcaacttc aagccctaat    540

agcagaaaag aaaatgcagc tagaaaggta tcgggttgaa tatgaagctt tgtgtaaagt    600

agaagcagaa caaaatgaat ttattgacca atttattttt cagaaatgaa ctgaaaattt    660

cgcttttata gtaggaaggc aaaacaaaaa aaagcctctc aaaaccaaaa aaacctctgt    720

agcattccag cggcttgacc aatgacctat gtcacaagag gtggcgtgta aggaatgcag    780

ccccctgaag acagcactac aagtctgggg gagccagttt taacatcagt gcacagctgc    840

tgctggtggc cctgcagtgt acgttctcac ctcttatgct tagttggaac taagcagttt    900

gtaaactttc atcctttttt ttgtaaattc acaaagcttt ggaaggagaa gcaataaatt    960

tttgttttca aatgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       1016


<210>  974
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  974

Met Ala Lys Asp Ile Leu Gly Glu Ala Gly Leu His Phe Asp Glu Leu 
1               5                   10                  15      


Asn Lys Leu Arg Val Leu Asp Pro Glu Val Thr Gln Gln Thr Ile Glu 
            20                  25                  30          


Leu Lys Glu Glu Cys Lys Asp Phe Val Asp Lys Ile Gly Gln Phe Gln 
        35                  40                  45              


Lys Ile Val Gly Gly Leu Ile Glu Leu Val Asp Gln Leu Ala Lys Glu 
    50                  55                  60                  


Ala Glu Asn Glu Lys Met Lys Ser Leu Ala Val Ser Pro Arg Leu Glu 
65                  70                  75                  80  


Cys Thr Gly Ala Ile Ser Ala His Cys Lys Leu Cys Leu Ser Asp Ser 
                85                  90                  95      


Ser Asp Ser Pro Thr Ser Pro Ser Arg Val Gly Gly Thr Thr Gly His 
            100                 105                 110         


Arg Cys Ser Glu Leu Ala Gln Ile Tyr Ser Lys Ala Glu Arg Ser Ser 
        115                 120                 125             


Thr Ala Ala Thr Ser Ser Pro Asn Ser Arg Lys Glu Asn Ala Ala Arg 
    130                 135                 140                 


Lys Val Ser Gly 
145             


<210>  975
<211>  3571
<212>  DNA
<213>  Homosapiens

<400>  975
cacagcttgg gactgctgag gggcaggcgg ctgcaggcta ggggcggctc ggagtccgct     60

ggccacccag ctgagaggag aggcgccccc ggggacgcac tgagattatg aggctctggc    120

ctccactggc cactcactcg tgaccctttc caccacggcg gagccttcca agcctacctc    180

ctgccgtgtg gtgatctacc tgcagcggga gatgtcgggg gacacctgcc tgtgcccagc    240

ctcaggggcc aagcccaagc tcagtggctt caagggagga gggttgggca acaagtatgt    300

ccagctcaac gtgggcggct ctctgtacta caccactgtg cgggccctga cccgccacga    360

caccatgctc aaggccatgt tcagtgggcg catggaggtg ctgaccgaca aagaaggctg    420

gatcctcata gaccgttgtg gaaagcactt tggcaccatt ttgaattacc tccgagatga    480

caccatcacc ctccctcaga accggcaaga aatcaaggaa ttgatggctg aagcaaagta    540

ttacctcatc caggggctgg tgaatatgtg ccagagtgcc ctgcaggaca agaaggactc    600

ctaccagcct gtgtgcaaca tccccatcat cacatcccta aaggaggagg agcggctcat    660

cgaatcctcc accaagcccg tggtgaagct gctgtacaac agaagcaaca acaagtattc    720

ctacaccagc aactctgacg accacctgct gaaaaacatc gagctgtttg acaagctctc    780

cctgcgcttc aacggccgcg tgctcttcat caaggatgtc attggtgacg agatctgctg    840

ctggtccttt tatggccagg gccgtaagct ggcagaggtg tgctgtacct ccatcgtgta    900

tgccacggag aagaagcaga ccaaggtgga attcccagag gcccgaatct atgaggagac    960

actcaacgtc ctactctatg agactccccg cgtccccgac aactccttgt tggaggccac   1020

aagccgtagc cgcagccagg cttcccccag tgaagatgag gagacctttg aactgcggga   1080

ccgtgtccgc cgcatccacg tcaagcgcta cagcacttac gatgaccggc agctcggcca   1140

ccagtctacc catcgcgact gaccagaccc tcagggagtc agggcacggg aggccctatc   1200

tcccatcctg tggaacccgc cccattggcc accccatgct gctgctgcct gggtctctgc   1260

tctagcaccc agaggcatga caggccctgc tcagaggtca gagggtctgg gcagaggagg   1320

gaccacattc ccctgccttg cccctgagca cttctggaga ctgcgtcctg tcctatctgc   1380

tcaccatcac ccttcctgcc cgacggagct gcttctgctc cctggggcat atggactgac   1440

ccacctcctg ctgagaacct tcccctaggc cctgtgcaga agggctactg ccccttaggc   1500

ctcagctggg ggaaaggcag ttctggtgct gtagaggccc tggtgcagaa agtgggacgt   1560

cttttttcct aaggtgttta agcacaggct tgataagttt ggtttttaaa aaataatcta   1620

ggaaatgaat aattctaaat ctagtaatga ggaaactgag catttctttt gccctccagg   1680

gtgccaagac cctacatatg acagaaccct tggcccttct ccatgcctgt gggatctgtt   1740

tctttaaagc actttgtact gttattcagg aggttgataa tctccttgac ccatgtcttt   1800

ctaccctaat ccccacttcc ctgcagaatc aatctgaggg aggggataaa gaggaagcaa   1860

taaaaaaaaa acatccgaca gagcagctct ggctttgcca gcctggccag cagctcagag   1920

tgcaccgagg agggaaggat ggctaagctg ggaccggcag tcctcacagg gtgcctgtga   1980

gaaaggacat tttaccccca catcatagtc acatcactga ctcctaggtc tagcacgact   2040

gctctttgtg attctcttga gtacccttgg cttccagcca tgctgtcctc acatacggta   2100

aagccaaaga gctgtcacat gggccagaaa catgagccac ggcaggaaga ccgtggagcc   2160

cgtgggcact gcatggtgtt ggctggcatg cccatcagct gaggacagca aactcccagc   2220

agcccctaca gaggtggcac atgcttggcc acacatctac tccctgccca caccatctat   2280

gctcttggtt ggtgctggct gggatggcgg ttctgcccag tggtgtctct gagcgcggga   2340

tgacaggagc aaccgaagca ccctgaaggc cttcactcct tgttgggtaa ctcagccatg   2400

gagatgccaa gcactagcca ggaggtgagt tcctctttag ggctttggtt ttcattcctt   2460

tttgtttggc ttggccaaac cagaattcag cttatctgaa ttattttcca aaggaatgct   2520

gtcagggagg gactgttctg ccagcctaac aaagcaacgt agccacgtat agtacccact   2580

ttctgctctt tggagagaac acaggttatc aagttcatct ctcttgacta ctcttatgat   2640

agctgatgcc acagagccta tgggcaaatg ccagacccag ggttagacac aaggacctga   2700

agtgacatga cggcgggaca ggggaaatgt gactttctaa ttaggcattt tatgttagtc   2760

acagtcttga atgtataaac agcactaaga ctctcaggtc aggtaccttg gtgatcagct   2820

actagttctt ccagccctca ttgaggtaac aagataaaga caaatccact tctttggcca   2880

aattcaggct ttggctttat gactttccca cagagactgg aatgcgtcag cctgagacca   2940

ctggcctatt ttctcagctg ccctcttgag gtcctttaac actcaaattc ccagctcccc   3000

actgaggtgt tgtgatgctt gccttttgac ctccccatcc cctttagtcc ctgcttacta   3060

ctttgacatt cacatcctca gtgtctcagt cttttttgcc gagaaagcac agtagtctgg   3120

gactgggcat ttatcttctc tgactgaaaa tctctccttg gtcttaagga aaatactaac   3180

attgaactca ctgacatgat cttagcttct ttaatcagac tttgtgactt aaaagtttgg   3240

gggttttctt tgaaagtttc cagccctatt cagaaagcaa ctcttggctg tgtgcatttt   3300

tcaactccaa gcagcccagg ggtaagtaaa caaagtatgg atgaaggtca gattttcttg   3360

tcagtttctg agaaacctgg cagcctgctg ttaacaacac aggccagtat tgggttttat   3420

tgaatttggt atgtgaccaa ggtcggccta aaggatggcg caggtcctgg gcaggaaaga   3480

atttttcctt tatcacataa ctgtaatatt tggttgctca gcataagtga tggaagcaaa   3540

cactaatttc taataaaatt gtgttaaact c                                  3571


<210>  976
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  976

Met Ser Gly Asp Thr Cys Leu Cys Pro Ala Ser Gly Ala Lys Pro Lys 
1               5                   10                  15      


Leu Ser Gly Phe Lys Gly Gly Gly Leu Gly Asn Lys Tyr Val Gln Leu 
            20                  25                  30          


Asn Val Gly Gly Ser Leu Tyr Tyr Thr Thr Val Arg Ala Leu Thr Arg 
        35                  40                  45              


His Asp Thr Met Leu Lys Ala Met Phe Ser Gly Arg Met Glu Val Leu 
    50                  55                  60                  


Thr Asp Lys Glu Gly Trp Ile Leu Ile Asp Arg Cys Gly Lys His Phe 
65                  70                  75                  80  


Gly Thr Ile Leu Asn Tyr Leu Arg Asp Asp Thr Ile Thr Leu Pro Gln 
                85                  90                  95      


Asn Arg Gln Glu Ile Lys Glu Leu Met Ala Glu Ala Lys Tyr Tyr Leu 
            100                 105                 110         


Ile Gln Gly Leu Val Asn Met Cys Gln Ser Ala Leu Gln Asp Lys Lys 
        115                 120                 125             


Asp Ser Tyr Gln Pro Val Cys Asn Ile Pro Ile Ile Thr Ser Leu Lys 
    130                 135                 140                 


Glu Glu Glu Arg Leu Ile Glu Ser Ser Thr Lys Pro Val Val Lys Leu 
145                 150                 155                 160 


Leu Tyr Asn Arg Ser Asn Asn Lys Tyr Ser Tyr Thr Ser Asn Ser Asp 
                165                 170                 175     


Asp His Leu Leu Lys Asn Ile Glu Leu Phe Asp Lys Leu Ser Leu Arg 
            180                 185                 190         


Phe Asn Gly Arg Val Leu Phe Ile Lys Asp Val Ile Gly Asp Glu Ile 
        195                 200                 205             


Cys Cys Trp Ser Phe Tyr Gly Gln Gly Arg Lys Leu Ala Glu Val Cys 
    210                 215                 220                 


Cys Thr Ser Ile Val Tyr Ala Thr Glu Lys Lys Gln Thr Lys Val Glu 
225                 230                 235                 240 


Phe Pro Glu Ala Arg Ile Tyr Glu Glu Thr Leu Asn Val Leu Leu Tyr 
                245                 250                 255     


Glu Thr Pro Arg Val Pro Asp Asn Ser Leu Leu Glu Ala Thr Ser Arg 
            260                 265                 270         


Ser Arg Ser Gln Ala Ser Pro Ser Glu Asp Glu Glu Thr Phe Glu Leu 
        275                 280                 285             


Arg Asp Arg Val Arg Arg Ile His Val Lys Arg Tyr Ser Thr Tyr Asp 
    290                 295                 300                 


Asp Arg Gln Leu Gly His Gln Ser Thr His Arg Asp 
305                 310                 315     


<210>  977
<211>  2703
<212>  DNA
<213>  Homosapiens

<400>  977
ggacgccgcg cggggcagtg tgggactggg gcggaacgcc gcccggccgc gggtcgggct     60

ctgtgtcagc agccgggcgg gcgctcgggc gggacatggc agcctgtaca gcccggcggg    120

ccctggccgt gggcagccgc tggtggtccc ggtcgctgac tggggcccgg tggccaaggc    180

cgctctgtgc ggcggccgga gctggagcct tctcgccagc gtcgaccacg acgacgcgga    240

ggcacctctc gtcccgaaac cgaccagagg gcaaagtgtt ggagacagtt ggtgtgtttg    300

aggtgccaaa acagaatgga aaatatgaga ccgggcagct tttccttcat agcatttttg    360

gctaccgagg tgtcgtcctg tttccctggc aggccagact gtatgaccgg gatgtggctt    420

ctgcagctcc agaaaaagca gagaaccctg ctggccatgg ctccaaggag gtgaaaggca    480

aaactcacac ttactatcag gtgctgattg atgctcgtga ctgcccacat atatctcaga    540

gatctcagac agaagctgtg accttcttgg ctaaccatga tgacagtcgg gccctctatg    600

ccatcccagg cttggactat gtcagccatg aagacatcct cccctacacc tccactgatc    660

aggttcccat ccaacatgaa ctctttgaaa gatttcttct gtatgaccag acaaaagcac    720

ctccttttgt ggctcgggag acgctaaggg cctggcaaga gaagaatcac ccctggctgg    780

agctctccga tgttcatcgg gaaacaactg agaacatacg tgtcactgtc atccccttct    840

acatgggcat gagggaagcc cagaattccc acgtgtactg gtggcgctac tgtatccgtt    900

tggagaacct tgacagtgat gtggtacagc tccgggagcg gcactggagg atattcagtc    960

tctctggcac cttggagaca gtgcgaggcc gaggggtagt gggcagggaa ccagtgttat   1020

ccaaggagca gcctgcgttc cagtatagca gccacgtctc actgcaggct tccagtgggc   1080

acatgtgggg cacgttccgc tttgaaagac ctgatggctc ccactttgat gttcggattc   1140

ctcccttctc cctggaaagc aataaagatg agaagacacc accctcaggc cttcactggt   1200

aggccagctg aggccccaag tgcccaggct tggtcaccgg gaagaacaac tctcatccca   1260

caattgctgc agaactcttc tctccccatc atgggccaca gtgggtctct taatttgatt   1320

gtggggttct ttttgtgggg aggggtggta taacttttct tcagaagacc catgtgggac   1380

acctccaagg ctggcctcct cataagccct gcctacacca tgttccagta aacctctcca   1440

ccaaggaact gtgttcagct gccacaggcc tggaggagtt tcctggcctg tcacgtgagg   1500

tttgatcagt aaaccagtgc acgcttggcc acccttgcca tttctgctcc cagagtctca   1560

ggctcccctt ctgacccagt gtgcgccctt gactgctttc tttgctgccc ttccagggag   1620

ctgcccccct ggtagggcat gtgcctgttt ccctctcagc ctggaggctg gctggacatc   1680

tcctagggtc actgtgcctc tcagctagtt ggcgggggtg ctggactgga ctcttgttca   1740

ctttaccttc tgccaaatgc agagagggag gccagtgtca gggtcggagt ggcctggctc   1800

ttagcactga ccgaccattg ccatttctgg cctcgctagg cccaggagag gagggaggca   1860

agccagtcgg gtttcctgga gcaatgggtg tgccagccct cagcatgact ctgccaagca   1920

tccagaccac aaatgcagga atttggctga ggagcagctt taggtatgga ttgatgacta   1980

agtcaagcta cttcctgagc ttctctcaga tttccaagag ccagagatga attgtgctgc   2040

atcttgcccc aattcttagg atttcttttc ctccgccact gcagtgattg ttagaggtag   2100

ttttcttgaa ttaatattaa atcacagttc cagcccttgt tattcttgtc cttagtcctc   2160

cagggggagc tggggttgca gggcaacagt acagtcgcgc ttacgacctg gctagaacac   2220

aaggtcagat gataaacaga agcacaggaa ctcagcccat ggccgcaagc tggtcaaggc   2280

ctgctcactg taaacatggc tctgtaccat tgagtttaac acaattttat tagaaattag   2340

tgtttgcttc catcacttat gctgagcaac caaatattac agttatgtga taaaggaaaa   2400

attctttcct gcccaggacc tgcgccatcc tttaggccga ccttggtcac ataccaaatt   2460

caataaaacc caatactggc ctgtgttgtt aacagcaggc tgccaggttt ctcagaaact   2520

gacaagaaaa tctgaccttc atccatactt tgtttactta cccctgggct gcttggagtt   2580

gaaaaatgca cacagccaag agttgctttc tgaatagggc tggaaacttt caaagaaaac   2640

ccccaaactt ttaagtcaca aagtctgatt aaagaagcta agatcaaaaa aaaaaaaaaa   2700

aaa                                                                 2703


<210>  978
<211>  368
<212>  PRT
<213>  Homosapiens

<400>  978

Met Ala Ala Cys Thr Ala Arg Arg Ala Leu Ala Val Gly Ser Arg Trp 
1               5                   10                  15      


Trp Ser Arg Ser Leu Thr Gly Ala Arg Trp Pro Arg Pro Leu Cys Ala 
            20                  25                  30          


Ala Ala Gly Ala Gly Ala Phe Ser Pro Ala Ser Thr Thr Thr Thr Arg 
        35                  40                  45              


Arg His Leu Ser Ser Arg Asn Arg Pro Glu Gly Lys Val Leu Glu Thr 
    50                  55                  60                  


Val Gly Val Phe Glu Val Pro Lys Gln Asn Gly Lys Tyr Glu Thr Gly 
65                  70                  75                  80  


Gln Leu Phe Leu His Ser Ile Phe Gly Tyr Arg Gly Val Val Leu Phe 
                85                  90                  95      


Pro Trp Gln Ala Arg Leu Tyr Asp Arg Asp Val Ala Ser Ala Ala Pro 
            100                 105                 110         


Glu Lys Ala Glu Asn Pro Ala Gly His Gly Ser Lys Glu Val Lys Gly 
        115                 120                 125             


Lys Thr His Thr Tyr Tyr Gln Val Leu Ile Asp Ala Arg Asp Cys Pro 
    130                 135                 140                 


His Ile Ser Gln Arg Ser Gln Thr Glu Ala Val Thr Phe Leu Ala Asn 
145                 150                 155                 160 


His Asp Asp Ser Arg Ala Leu Tyr Ala Ile Pro Gly Leu Asp Tyr Val 
                165                 170                 175     


Ser His Glu Asp Ile Leu Pro Tyr Thr Ser Thr Asp Gln Val Pro Ile 
            180                 185                 190         


Gln His Glu Leu Phe Glu Arg Phe Leu Leu Tyr Asp Gln Thr Lys Ala 
        195                 200                 205             


Pro Pro Phe Val Ala Arg Glu Thr Leu Arg Ala Trp Gln Glu Lys Asn 
    210                 215                 220                 


His Pro Trp Leu Glu Leu Ser Asp Val His Arg Glu Thr Thr Glu Asn 
225                 230                 235                 240 


Ile Arg Val Thr Val Ile Pro Phe Tyr Met Gly Met Arg Glu Ala Gln 
                245                 250                 255     


Asn Ser His Val Tyr Trp Trp Arg Tyr Cys Ile Arg Leu Glu Asn Leu 
            260                 265                 270         


Asp Ser Asp Val Val Gln Leu Arg Glu Arg His Trp Arg Ile Phe Ser 
        275                 280                 285             


Leu Ser Gly Thr Leu Glu Thr Val Arg Gly Arg Gly Val Val Gly Arg 
    290                 295                 300                 


Glu Pro Val Leu Ser Lys Glu Gln Pro Ala Phe Gln Tyr Ser Ser His 
305                 310                 315                 320 


Val Ser Leu Gln Ala Ser Ser Gly His Met Trp Gly Thr Phe Arg Phe 
                325                 330                 335     


Glu Arg Pro Asp Gly Ser His Phe Asp Val Arg Ile Pro Pro Phe Ser 
            340                 345                 350         


Leu Glu Ser Asn Lys Asp Glu Lys Thr Pro Pro Ser Gly Leu His Trp 
        355                 360                 365             


<210>  979
<211>  1466
<212>  DNA
<213>  Homosapiens

<400>  979
gctagatatg gcgtcctctt tgcttgcggg cgagcgattg gtgcgtgctt tgggccccgg     60

cggggagctg gagccagagc ggctaccccg aaagctgcgg gccgagcttg aggccgcgct    120

ggggaagaag cacaagggcg gtgatagctc cagtggcccc caacgcttgg tttctttccg    180

tctcatccgg gatctgcacc agcatctgag agaaagggat tccaaactat acctccatga    240

gctcctagaa ggcagtgaaa tctatctccc agaggttgtg aagcctccac ggaacccaga    300

actagttgcc cggctggaga agattaagat acagctggcc aatgaggaat ataaacggat    360

cacccgcaac gtcacttgtc aggatacaag acatggtggg actctcagcg acctgggaaa    420

gcaagtgaga tcattgaagg ctctggtcat caccatcttc aatttcattg tcacggtggt    480

tgctgccttc gtctgcactt accttggaag ccaatatatc ttcacagaaa tggcctcgcg    540

ggtgctagct gcattgatcg tcgcctctgt ggtgggtctg gccgagctgt atgtcatggt    600

gcgggcaatg gaaggcgagc tgggagaact gtaactggtg cttcatcatc aagtctagag    660

aagactttgg gggcttcagg ctccaattgg cagtcaccga ctcagtcaac ccatcagact    720

ttttgtattc agctccagtt agtcagaaga ccagcccagg ccagctgctg tttctgtggg    780

gagccctaat cttctgtgaa tttccaaagg gagcattgga ggagattgag ataacacatc    840

tttaaaacag aaagaactgg tcttggtcta tcagtacctc ttcctgaatc tggtacccat    900

ctgccttctc cagttcattc taaacactgc tgggactagg gtttttccat caggagcaaa    960

tggaatccag gccttcccag aagtagacca tactgccttg aacttgtcca tatgtacaaa   1020

ctaatcacca gctttctcca tacattttta atgcagacct gtaattgagt tcagaagcct   1080

ccaagaaaac agaaaggatc ccctttctcc agtttgtgct ggaagaggag ctgatcagag   1140

acatcaaata agagaaagat gggttgctag aggatggtag aactggaagc aaggcagcta   1200

cctttttgca aaaggaaatg gtgttaggcc ccttttccag aagataagac agactcatag   1260

agattaaatg atcactatgg tccttcttct gttaaatgga gccaaagacg cctatgttgt   1320

tctgaagtct tgtaatgttt aacttctgag aacttagatt agtggtgtga tgatagagtc   1380

tgtataacgc attgaaaagg gtatcaggct tagttattta tccaataaat atttattgta   1440

tgcagggtaa aaaaaaaaaa aaaaaa                                        1466


<210>  980
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  980

Met Ala Ser Ser Leu Leu Ala Gly Glu Arg Leu Val Arg Ala Leu Gly 
1               5                   10                  15      


Pro Gly Gly Glu Leu Glu Pro Glu Arg Leu Pro Arg Lys Leu Arg Ala 
            20                  25                  30          


Glu Leu Glu Ala Ala Leu Gly Lys Lys His Lys Gly Gly Asp Ser Ser 
        35                  40                  45              


Ser Gly Pro Gln Arg Leu Val Ser Phe Arg Leu Ile Arg Asp Leu His 
    50                  55                  60                  


Gln His Leu Arg Glu Arg Asp Ser Lys Leu Tyr Leu His Glu Leu Leu 
65                  70                  75                  80  


Glu Gly Ser Glu Ile Tyr Leu Pro Glu Val Val Lys Pro Pro Arg Asn 
                85                  90                  95      


Pro Glu Leu Val Ala Arg Leu Glu Lys Ile Lys Ile Gln Leu Ala Asn 
            100                 105                 110         


Glu Glu Tyr Lys Arg Ile Thr Arg Asn Val Thr Cys Gln Asp Thr Arg 
        115                 120                 125             


His Gly Gly Thr Leu Ser Asp Leu Gly Lys Gln Val Arg Ser Leu Lys 
    130                 135                 140                 


Ala Leu Val Ile Thr Ile Phe Asn Phe Ile Val Thr Val Val Ala Ala 
145                 150                 155                 160 


Phe Val Cys Thr Tyr Leu Gly Ser Gln Tyr Ile Phe Thr Glu Met Ala 
                165                 170                 175     


Ser Arg Val Leu Ala Ala Leu Ile Val Ala Ser Val Val Gly Leu Ala 
            180                 185                 190         


Glu Leu Tyr Val Met Val Arg Ala Met Glu Gly Glu Leu Gly Glu Leu 
        195                 200                 205             


<210>  981
<211>  2022
<212>  DNA
<213>  Homosapiens

<400>  981
caatcatgga tcaatagcta tgtttggaga aggaatttgt ggctgctcca gctactgggc     60

attttgtctg gtccagttca tgtaatctcc caacacccca tgaagcaagg ctttgttaat    120

cctattttac tgaaaatgaa ctaagactca gagagataaa gctgttgccc aatgagcctt    180

ctttctgccc tccagatcca cggtgctaat tccccttccg atgacctaat gattctgagc    240

ttggcaaagg tcttatctcc cagctcgccc aggcccagtg ttccaggaat gtgacctttg    300

ctgcagcagc cgctggaggg ggcagagggg atgggctgga ggttgagcaa acagagcagc    360

agaaaaggca gttcctcttc tccagtgccc tccttccctg tctctgcctc tccctccctt    420

cctcaggcat cagagcggag acttcaggga gaccagagcc cagcttgcca ggcactgagc    480

tagaagccct gccatggcac ccctgagacc ccttctcata ctggccctgc tggcatgggt    540

tgctctggct gaccaagagt catgcaaggg ccgctgcact gagggcttca acgtggacaa    600

gaagtgccag tgtgacgagc tctgctctta ctaccagagc tgctgcacag actatacggc    660

tgagtgcaag ccccaagtga ctcgcgggga tgtgttcact atgccggagg atgagtacac    720

ggtctatgac gatggcgagg agaaaaacaa tgccactgtc catgaacagg tggggggccc    780

ctccctgacc tctgacctcc aggcccagtc caaagggaat cctgagcaga cacctgttct    840

gaaacctgag gaagaggccc ctgcgcctga ggtgggcgcc tctaagcctg aggggataga    900

ctcaaggcct gagacccttc atccagggag acctcagccc ccagcagagg aggagctgtg    960

cagtgggaag cccttcgacg ccttcaccga cctcaagaac ggttccctct ttgccttccg   1020

agggcagtac tgctatgaac tggacgaaaa ggcagtgagg cctgggtacc ccaagctcat   1080

ccgagatgtc tggggcatcg agggccccat cgatgccgcc ttcacccgca tcaactgtca   1140

ggggaagacc tacctcttca agggtagtca gtactggcgc tttgaggatg gtgtcctgga   1200

ccctgattac ccccgaaata tctctgacgg cttcgatggc atcccggaca acgtggatgc   1260

agccttggcc ctccctgccc atagctacag tggccgggag cgggtctact tcttcaaggg   1320

gaaacagtac tgggagtacc agttccagca ccagcccagt caggaggagt gtgaaggcag   1380

ctccctgtcg gctgtgtttg aacactttgc catgatgcag cgggacagct gggaggacat   1440

cttcgagctt ctcttctggg gcagaacctc tgctggtacc agacagcccc agttcattag   1500

ccgggactgg cacggtgtgc cagggcaagt ggacgcagcc atggctggcc gcatctacat   1560

ctcaggcatg gcaccccgcc cctccttggc caagaaacaa aggtttaggc atcgcaaccg   1620

caaaggctac cgttcacaac gaggccacag ccgtggccgc aaccagaact cccgccggcc   1680

atcccgcgcc atgtggctgt ccttgttctc cagtgaggag agcaacttgg gagccaacaa   1740

ctatgatgac tacaggatgg actggcttgt gcctgccacc tgtgaaccca tccagagtgt   1800

cttcttcttc tctggagaca agtactaccg agtcaatctt cgcacacggc gagtggacac   1860

tgtggaccct ccctacccac gctccatcgc tcagtactgg ctgggctgcc cagctcctgg   1920

ccatctgtag gagtcagagc ccacatggcc gggccctctg tagctccctc ctcccatctc   1980

cttcccccag cccaataaag gtcccttagc cccgagttta aa                      2022


<210>  982
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  982

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Met 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210>  983
<211>  6862
<212>  DNA
<213>  Homosapiens

<400>  983
gccgagcggc tggcggtgcc tgggccagat gggggcggtg gcacgggccc atggtgggct     60

gcgggtggcc cgggcccgcg aaagtgtcgc cgggggcagg caccgaggtg caggacgccc    120

tggagcgcgc gctgccggag ctgcagcagg ccttgtccgc gctgaagcag gcgggcggcg    180

cgcgggccgt gggcgccggc ctggccgagg tcttccaact ggtggaggag gcctggctgc    240

tgcggccgtg ggccgcgagg tagcccaggg tctgtgcgac gccatccgcc tcgatggcgg    300

cctcgacctg ctgttgcggc tgctgcaggc gccggagttg gagacgcgtg tgcaggccgc    360

gcgcctgctg gagcagatcc tggtggctga gaaccgagac cgcgtggcgc gcattgggct    420

gggcgtgatc ctgaacctgg cgaaggaacg cgaacccgta gagctggcgc ggagcgtggc    480

aggcatcttg gagcacatgt tcaagcattc ggaggagaca tgccagaggc tggtggcggc    540

cggcggcctg gacgcggtgc tgtattggtg ccgccgcacg gaccccgcgc tgctgcgcca    600

ctgcgcgctg gcgctgggca actgcgcgct gcacgggggc caggcggtgc agcgacgcat    660

ggtagagaag cgcgcagccg agtggctctt cccgctcgcc ttctccaagg aggacgagct    720

gcttcggctg cacgcctgcc tcgcagtagc ggtgttggcg actaacaagg aggtggagcg    780

cgaggtggag cgctcgggca cgctggcgct cgtggagccg cttgtggcct cgctggaccc    840

tggccgcttc gcccgctgtc tggtggacgc cagcgacaca agccagggcc gcgggcccga    900

cgacctgcag cgcctcgtgc cgttgctcga ctctaaccgc ttggaggcgc agtgcatcgg    960

ggctttctac ctctgcgccg aggctgccat caagagcctg caaggcaaga ccaaggtgtt   1020

cagcgacatc ggcgccatcc agagcctgaa acgcctggtt tcctactcta ccaatggcac   1080

taagtcggcg ctggccaagc gcgcgctgcg cctgctgggc gaggaggtgc cacggcccat   1140

cctgccctcc gtgcccagct ggaaggaggc cgaggttcag acgtggctgc agcagatcgg   1200

tttctccaag tactgcgaga gcttccggga gcagcaggtg gatggcgacc tgcttctgcg   1260

gctcacggag gaggaactcc agaccgacct gggcatgaaa tcgggcatca cccgcaagag   1320

gttctttagg gagctcacgg agctcaagac cttcgccaac tattctacgt gcgaccgcag   1380

caacctggcg gactggctgg gcagcctgga cccgcgcttc cgtcagtaca cctacggcct   1440

ggtcagctgc ggcctggacc gctccctgct gcaccgcgtg tctgagcagc agctgctgga   1500

agactgcggc atccacctgg gcgtgcaccg cgcccgcatc ctcacggcgg ccagagaaat   1560

gctacactcc ccgctgccct gtactggtgg caaacccagt ggggacactc cagatgtctt   1620

catcagctac cgccggaact caggttccca gctggccagt ctcctgaagg tgcacctgca   1680

gctgcatggc ttcagtgtct tcattgatgt ggagaagctg gaagcaggca agttcgagga   1740

caaactcatc cagagtgtca tgggtgcccg caactttgtg ttggtgctat cacctggagc   1800

actggacaag tgcatgcaag accatgactg caaggattgg gtgcataagg agattgtgac   1860

tgctttaagc tgcggcaaga acattgtgcc catcattgat ggcttcgagt ggcctgagcc   1920

ccaggtcctg cctgaggaca tgcaggctgt gcttactttc aacggtatca agtggtccca   1980

cgaataccag gaggccacca ttgagaagat catccgcttc ctgcagggcc gctcctcccg   2040

ggactcatct gcaggctctg acaccagttt ggagggtgct gcacccatgg gtccaaccta   2100

accagtcccc agttccccag ccctgctgtg acttccattt ccatcgtcct ttctgaagga   2160

acagctcctg aaaccagtct ccctgggctg agacaacctg ggctcttctt aggaaatggc   2220

tctccctccc cctgtccccc accctcatgg cccacctcca acccactttc ctcagtatct   2280

ggagagggaa gggaagtcag gcttgggcac gggaggttag aactccccca ggccctgcca   2340

ttgggttgtc tgtctccgtc atggggaggg tccctgctca gttctggaga cactggagtt   2400

ggggtggggg tggttctgca ttcccttctc ctgctgatag cagtcagctt gaggaggatg   2460

aaggaaggca gcctcagaca ggaattaagg caatgcccag gcgggcctgg gcactgtatt   2520

ctgagcaagg gcctgggccc aggagccagc cagggatgag tgccatcatg gctctccact   2580

cagactgtgc ctggcccctg cacttacaac ttcctgccgc tctgtggcct tgccctgtaa   2640

tcactcagtg cccttagcta gcctgactaa gtcccagatc ccctacagct tccttcggtg   2700

tggtatcttt tgccacatcc agggcgaggg ttgaggcaaa ccagccctcc ctctgacttc   2760

cttgtcactg cagccagctt tgctgcactt gctggtgcac aggagcctcc tgtttgggcc   2820

tgggtctggg catggggagg ccgtgcctca aagcccaccc taccccatgc cttggtgctg   2880

tgcctcaggc tccttcctgg tctggcccag ctggcttccc cagcccctca gccatccagg   2940

gctacccact gcttactcag ggaccaggca gcccccatgg cagtaaaagc agcctagaca   3000

gaacctgcag ctctgtggaa agaggcaaag tcctgaaaag gcaaagggtt gtcacttagg   3060

gcagcttctc caactttaac atgcatccaa gtcacctggg aatgttgtta aaatcaggag   3120

atctggggtg gggcctagga ctctgcattt cttacagatt cccaggtgag ctgatgctgg   3180

tggttaaggg tagcaaatct ctaaagcacg aagccctcac aaatctttgc catttcccaa   3240

acactccgct ccatggtctc cagtcatcag agcaactcta cctggtatta tcatccccat   3300

tttacagata atgacactga ggctcagaaa ggttgaggat aagcccactt tcctgtcatt   3360

agtggcagcc ccagatccag acctaggcct cctggcaccc agtccactgg cagtggaatt   3420

gctttcctga gaatcattct gaggctgggc tattgcttct cccttgcttc aaagaatcta   3480

gcagcggggg ataggatttt gcaacaaaaa gctgacccag aggccataca gagcaggaat   3540

atcccattgc cccctcctcc actgggttca gagggtaaga aagcaccctc caataaaccc   3600

aggctccagg ccgtgggggc tgctgaaggc tctttccccg caagggccag gtgttgacac   3660

cttaaagctg gctgcgcccc cagccccact cttggctgtg ctggccaggt gactcctagt   3720

tcttggccac atcatcagaa agtcaaaggt ctcactccag gtttggggct ccttccttcc   3780

actcccctcc ctgccagagt ctgtcttggc cagtgccagc ctcgatgctt tggttttgac   3840

cccacctgat cctcctttcc tcatgcagca caagtgctca ccggggccag agccagggca   3900

tggatatgac aagcagggca gcctggacac tgccctcaca ggacagcgcc aataacaata   3960

cagtgtctga gtatctccag gggatgattt ctggctcttt gtctccaatc agtcccactc   4020

cctcctgagg tccccaaggg cagtattcag agaggtttcc tgcgttttat ttctatttgg   4080

tataccctcc actgttgtcc actgccctgt gtggccttct ggttgacctc tgcccgatct   4140

tctgtctctc tgagggaatc agagtccagc atccagcccc agctggaaca gctgaagtca   4200

caagcctcct ctaagccaag gccagtgtgt tcagaggtga ctgccaccca tactaggaca   4260

aacacagctc agatcaccag gtcaagcacc taggcctggc ttctcctgag acagaggact   4320

cagaagtggc ctttcctcca aagcctgctc agacacaggt ctgtagggcc agggtgttct   4380

gcttggctgg gctgcagctg ctacccctcg gttggggctg agtcagccag atcctccccc   4440

tacttctccc caagggccaa gaactgctca gggacattaa aggtcaaaag tccagccaca   4500

ctcattcatc ctttccccag gcccatgaag agaggcatct cattgtagaa tgtatgagga   4560

agtgggaagt atctcagaga atcagctaag tttcctaact tgtccatcca aatgtgatca   4620

ccacgattca acaatttggg gcattgctga tctagccgtt cctagtgggg cttgctcaag   4680

gttgcacagc gagtcagtag aagccctggc tggccccact tggtaccaat ccaccaggca   4740

gctcagggct cctgcccagc ccagcagctt ctgttgtcta acgtatggca ggcagactgg   4800

gagcaggaaa acagagggcc ccaaagccca aggcaccaga aggtttgttt cagtttgctg   4860

aagctgattt gtaatgattg gcactcttca gccaggggag tgggtaggcc atagccaagg   4920

atcgattccc caaccacagc aaaggcaaca ctcttcctcc agagatcacc aagcccctct   4980

tacctccctc cctccttccc aaggctggca ctaaccaggt accacattca ttgttaagga   5040

atggctgatg actgctacac gtgttgggaa cctggttggg gctgtgcagt ttgggctgga   5100

aggagagatg ccagccctcg tgctgcctct ggtccctgaa gtgtcacctc tctcaggacc   5160

tctcctctgg cctgtggggt tataagtgat ggatagcaga aagggagaac tgactcctgt   5220

cccaaatagc tcctctgcca cctgtcctgc agtgggcctg tgtgggttat gattctagat   5280

cctagacaga ggctgggtca gctgtggatg gggtggtgcc ttggtctctc ttgactacct   5340

cgtccaaaga gagcactgcc cttagacaag agttgcttgt cctgctgtgg gctgggcttc   5400

cagctgcaga cctccagttg cttggtgttc actttgctcc tcttgccctc tgtcttctgg   5460

tccaggcaga tcaggggctc tggggaaact gctggaactc gaggtgagga tcagcctttt   5520

ccagcatcct gtgagagacc agagagagag tttggatttc atgtggggaa ccctcaaggc   5580

ctgtctggag aagtgacaca ggatttactg gggtgggctg gtccaggtag ctctcctgaa   5640

cctcctcctt ccccaagctg agaagctgag agctggagga caatatccag ggacatggct   5700

ctggaaaata actttttttt tttaagagac agggtcttgc tctgttgtcc aggctggagg   5760

gcagtgacat aatcatagct cactgtaccc ttgaactcct gggctcaagt gatcctcctg   5820

cctcagcctc cttagtagct gggactacca gtgcatacca ccatgcctgg gtgatttttt   5880

aaatttttta tacagacaag gtcttgctat gttgcccagg ctgatcttga attcccgggc   5940

tcaagtggtc ctcctgcctc agcctcccac aggatcggga ttacaggcaa gagcctccac   6000

gcccggccat gaaatataat tcttaatatc atacaggaaa aagtcagcgg gtcaagctag   6060

cctgtggccc agccacaact agctgacaaa gcttcctggc cttcccttta acacagttct   6120

gctgccatag ttccatctat aaaatgggaa tggagggaaa taggggaact gggagagaga   6180

acacagcctt gccaagcagc aatgttagcc tgatccttcc tccacctagc tcgccatctc   6240

gcccttggaa aatggctcct ggaggattag gcagccatct gcaaggagag gggcaacctg   6300

ggacaagaca cccagagggt aaggattcca ggaatgaagc tgccatttct ggttgggagg   6360

agaagaggaa acttttaaga gaaagggctc cattatgagc atgggttcag ggccctgcat   6420

tacccaatca gaacagccgg gatgagcagg aggccagctc ccaggaggaa ggggaacccc   6480

ttcataaagt tcagagtggc tgggtagagt gagttgaaga tgccggaggc cgtcagcatg   6540

gccaggctat tcacacaggc cacagcagaa aagagagcac ctgtgaagaa ataaatacca   6600

tactctggag tccgaaaggg ccatattcca actctggcac caccacctca cagctgtgtg   6660

accgggagta gtcacttaac ctatgtctcc ccttcctcac cagtaaatcc tgctacatca   6720

tgtactgtga caaggattca gtaaggtcat atgtggacag tagctggcac agaggggcta   6780

ctaaacaaat ggctgctatt aaatccacat taaaagtaca tgtgatctga cagaacccag   6840

cacataaaag aaaaaaaaaa gt                                            6862


<210>  984
<211>  690
<212>  PRT
<213>  Homosapiens

<400>  984

Met Gly Ala Val Ala Arg Ala His Gly Gly Leu Arg Val Ala Arg Ala 
1               5                   10                  15      


Arg Glu Ser Val Ala Gly Gly Arg His Arg Gly Ala Gly Arg Pro Gly 
            20                  25                  30          


Ala Arg Ala Ala Gly Ala Ala Ala Gly Leu Val Arg Ala Glu Ala Gly 
        35                  40                  45              


Gly Arg Arg Ala Gly Arg Gly Arg Arg Pro Gly Arg Gly Leu Pro Thr 
    50                  55                  60                  


Gly Gly Gly Gly Leu Ala Ala Ala Ala Val Gly Arg Glu Val Ala Gln 
65                  70                  75                  80  


Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu Leu Leu 
                85                  90                  95      


Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala Ala Arg 
            100                 105                 110         


Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val Ala Arg 
        115                 120                 125             


Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu Pro Val 
    130                 135                 140                 


Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe Lys His 
145                 150                 155                 160 


Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu Asp Ala 
                165                 170                 175     


Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg His Cys 
            180                 185                 190         


Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala Val Gln 
        195                 200                 205             


Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro Leu Ala 
    210                 215                 220                 


Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu Ala Val 
225                 230                 235                 240 


Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu Arg Ser 
                245                 250                 255     


Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp Pro Gly 
            260                 265                 270         


Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln Gly Arg 
        275                 280                 285             


Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser Asn Arg 
    290                 295                 300                 


Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu Ala Ala 
305                 310                 315                 320 


Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile Gly Ala 
                325                 330                 335     


Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly Thr Lys 
            340                 345                 350         


Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu Val Gln 
    370                 375                 380                 


Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser Phe Arg 
385                 390                 395                 400 


Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu Glu Glu 
                405                 410                 415     


Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys Arg Phe 
            420                 425                 430         


Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser Thr Cys 
        435                 440                 445             


Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro Arg Phe 
    450                 455                 460                 


Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg Ser Leu 
465                 470                 475                 480 


Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly Ile His 
                485                 490                 495     


Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu Met Leu 
            500                 505                 510         


His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp Thr Pro 
        515                 520                 525             


Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu Ala Ser 
    530                 535                 540                 


Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe Ile Asp 
545                 550                 555                 560 


Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile Gln Ser 
                565                 570                 575     


Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly Ala Leu 
            580                 585                 590         


Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His Lys Glu 
        595                 600                 605             


Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile Ile Asp 
    610                 615                 620                 


Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met Gln Ala 
625                 630                 635                 640 


Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln Glu Ala 
                645                 650                 655     


Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser Arg Asp 
            660                 665                 670         


Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro Met Gly 
        675                 680                 685             


Pro Thr 
    690 


<210>  985
<211>  2096
<212>  DNA
<213>  Homosapiens

<400>  985
acagcgcaag ccccacgcca cgcgtcgctg gtcccaggca gcgagtcgct cgcgcgcccc     60

gccgcccgcc tggcgacagc tccgccgcgc acgcacatgg aggggagcgc gagccccccg    120

gaaaagcccc gcgcccgccc tgcggctgcc gtgctgtgcc ggggcccggt agagccgctg    180

gtcttcctgg ccaactttgc cttggtcctg cagggcccgc tcaccacgca gtatctgtgg    240

caccgcttca gcgccgacct cggctacaat ggcacccgcc aaaggggggg ctgcagcaac    300

cgcagcgcgg accccaccat gcaggaagtg gagaccctta cctcccactg gaccctctac    360

atgaacgtgg gcggcttcct ggtggggctc ttctcgtcca ccctgctggg agcttggagc    420

gacagtgtgg gccgccgccc gctgctagtg ctggcctcgc tgggcctgct gctccaggcc    480

ctagtgtccg tttttgtggt gcagctgcag ctccacgtcg gctacttcgt gctgggtcgc    540

atcctttgtg ccctcctcgg cgacttcggt ggccttctgg ctgctagctt tgcgtccgtg    600

gcagatgtca gctccagtcg cagccgcacc ttccggatgg ccctgctaga agccagcatc    660

ggggtggctg ggatgctggc aagcctcctc gggggccact ggctccgggc ccagggttat    720

gccaacccct tctggctggc cttggccttg ctgatagcca tgactctcta tgcagctttc    780

tgctttggtg agaccttaaa ggagccaaag tccacccggc tcttcacgtt ccgtcaccac    840

cgatccattg tccagctcta tgtggctccc gccccagaga agtccaggaa acatttagcc    900

ctctactcac tggccatctt cgtggtgatc actgtgcact ttggggccca ggacatctta    960

accctttatg aactaagcac acccctctgc tgggactcca aactaatcgg ctatggttct   1020

gcagctcagc atctccccta cctcaccagc ctgctggccc tgaagctcct gcagtactgc   1080

ctggccgatg cctgggtagc tgagatcggc ctggccttca acatcctggg gatggtggtc   1140

tttgcctttg ccactatcac gcctctcatg ttcacaggat atgggttgct tttcctgtca   1200

ttagtcatca cacctgtcat ccgggctaaa ctctccaagc tggtgagaga gacagagcag   1260

ggtgctctct tttctgctgt ggcctgtgtg aatagcctgg ccatgctgac ggcctccggc   1320

atcttcaact cactctaccc agccactctg aactttatga aggggttccc cttcctcctg   1380

ggagctggcc tcctgctcat cccggctgtt ctgattggga tgctggaaaa ggctgatcct   1440

cacctcgagt tccagcagtt tccccagagc ccctgatctg cctggaccag aagacagagg   1500

gcaagaggag caaagtgaac accaagcaac tggaggtctg cagctggaag cccagcccac   1560

agcaggacaa gcaactcttg tctaagggca gtgctctctt tggacgaggt agtcaagaga   1620

gaccaaggca ccaccccatc cacagctgac ccagcctctg tctaggatct agaatcataa   1680

cccacacagg cccactgcag gacaggtggc agaggagcta tttgggacag gagtcagttc   1740

tccctttctg ctatccatca cttataaccc cacaggccag aggagaggtc ctgagagagg   1800

tgacacttcg gggaccagag gcagcacgag ggctggcatc tctccttcca gcccaaactg   1860

cacagcccca accaggttcc caacacgtgt agcagtcatc agccattcct taacaatgaa   1920

tgtggtacct ggttagtgcc agccttggga aggagggagg gaggtaagag gggcttggtg   1980

atctctggag gaagagtgtt gcctttgctg tggttgggga atcgatcctt ggctatggcc   2040

tacccactcc cctggctgaa gagtgccaat cattacaaat cagcttcagc aaactg       2096


<210>  986
<211>  459
<212>  PRT
<213>  Homosapiens

<400>  986

Met Glu Gly Ser Ala Ser Pro Pro Glu Lys Pro Arg Ala Arg Pro Ala 
1               5                   10                  15      


Ala Ala Val Leu Cys Arg Gly Pro Val Glu Pro Leu Val Phe Leu Ala 
            20                  25                  30          


Asn Phe Ala Leu Val Leu Gln Gly Pro Leu Thr Thr Gln Tyr Leu Trp 
        35                  40                  45              


His Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln Arg Gly 
    50                  55                  60                  


Gly Cys Ser Asn Arg Ser Ala Asp Pro Thr Met Gln Glu Val Glu Thr 
65                  70                  75                  80  


Leu Thr Ser His Trp Thr Leu Tyr Met Asn Val Gly Gly Phe Leu Val 
                85                  90                  95      


Gly Leu Phe Ser Ser Thr Leu Leu Gly Ala Trp Ser Asp Ser Val Gly 
            100                 105                 110         


Arg Arg Pro Leu Leu Val Leu Ala Ser Leu Gly Leu Leu Leu Gln Ala 
        115                 120                 125             


Leu Val Ser Val Phe Val Val Gln Leu Gln Leu His Val Gly Tyr Phe 
    130                 135                 140                 


Val Leu Gly Arg Ile Leu Cys Ala Leu Leu Gly Asp Phe Gly Gly Leu 
145                 150                 155                 160 


Leu Ala Ala Ser Phe Ala Ser Val Ala Asp Val Ser Ser Ser Arg Ser 
                165                 170                 175     


Arg Thr Phe Arg Met Ala Leu Leu Glu Ala Ser Ile Gly Val Ala Gly 
            180                 185                 190         


Met Leu Ala Ser Leu Leu Gly Gly His Trp Leu Arg Ala Gln Gly Tyr 
        195                 200                 205             


Ala Asn Pro Phe Trp Leu Ala Leu Ala Leu Leu Ile Ala Met Thr Leu 
    210                 215                 220                 


Tyr Ala Ala Phe Cys Phe Gly Glu Thr Leu Lys Glu Pro Lys Ser Thr 
225                 230                 235                 240 


Arg Leu Phe Thr Phe Arg His His Arg Ser Ile Val Gln Leu Tyr Val 
                245                 250                 255     


Ala Pro Ala Pro Glu Lys Ser Arg Lys His Leu Ala Leu Tyr Ser Leu 
            260                 265                 270         


Ala Ile Phe Val Val Ile Thr Val His Phe Gly Ala Gln Asp Ile Leu 
        275                 280                 285             


Thr Leu Tyr Glu Leu Ser Thr Pro Leu Cys Trp Asp Ser Lys Leu Ile 
    290                 295                 300                 


Gly Tyr Gly Ser Ala Ala Gln His Leu Pro Tyr Leu Thr Ser Leu Leu 
305                 310                 315                 320 


Ala Leu Lys Leu Leu Gln Tyr Cys Leu Ala Asp Ala Trp Val Ala Glu 
                325                 330                 335     


Ile Gly Leu Ala Phe Asn Ile Leu Gly Met Val Val Phe Ala Phe Ala 
            340                 345                 350         


Thr Ile Thr Pro Leu Met Phe Thr Gly Tyr Gly Leu Leu Phe Leu Ser 
        355                 360                 365             


Leu Val Ile Thr Pro Val Ile Arg Ala Lys Leu Ser Lys Leu Val Arg 
    370                 375                 380                 


Glu Thr Glu Gln Gly Ala Leu Phe Ser Ala Val Ala Cys Val Asn Ser 
385                 390                 395                 400 


Leu Ala Met Leu Thr Ala Ser Gly Ile Phe Asn Ser Leu Tyr Pro Ala 
                405                 410                 415     


Thr Leu Asn Phe Met Lys Gly Phe Pro Phe Leu Leu Gly Ala Gly Leu 
            420                 425                 430         


Leu Leu Ile Pro Ala Val Leu Ile Gly Met Leu Glu Lys Ala Asp Pro 
        435                 440                 445             


His Leu Glu Phe Gln Gln Phe Pro Gln Ser Pro 
    450                 455                 


<210>  987
<211>  2723
<212>  DNA
<213>  Homosapiens

<400>  987
gggcggggcg caggagcccc ggggcggagg agccggggag gcgggaggcg ggaggcggga     60

ggtgttgggg ccgttgaagc ggcctccctc ccgcccccag ccgcccggtc tggccccagc    120

cctgtcccga cccccggcct ggcccactcc gaccctaccc ggccgaaggg ttccgctgga    180

cacgcaggcg gcctccggag cagcccaagc ccatgagggc cgcgcgcccg gccgccggtg    240

ctgacgagac ggagctcctg gcccccgagg aggagcagag gatcaatgcg gttcaagaat    300

cgattccagc ggttcatgaa ccatcgagct ccagccaatg gccgctacaa gccaacttgc    360

tatgaacatg ctgctaactg ttacacacac gcattcctca ttgttccggc catcgtgggc    420

agtgccctcc tccatcggct gtctgatgac tgctgggaaa agataacagc atggatttat    480

ggaatgggac tctgtgccct cttcatcgtt tctacagtat ttcacattgt atcatggaaa    540

aagagccact taaggacagt ggagcattgt tttcacatgt gtgatagaat ggttatctat    600

ttcttcattg ctgcttctta tgctccatgg ttaaatcttc gtgaacttgg acccctggca    660

tctcatatgc gttggtttat ctggctcatg gcagctggag gaaccattta tgtatttctc    720

taccatgaaa aatataaggt ggttgaactc tttttctatc tcacaatggg attctctcca    780

gccttggtgg tgacatcaat gaacaacacc gatggacttc aggaacttgc ctgtgggggc    840

ttaatttatt gcttgggagt tgtgttcttc aagagtgatg gcatcattcc atttgcccac    900

gccatctggc acctgtttgt ggccacggca gctgcagtgc attactacgc catttggaaa    960

tacctttacc gaagtcctac ggactttatg cggcatttat gaccaatctg tactaattct   1020

ccaaaccagt attatttcaa ttatggcact tgggagtggg gtgagagcta aacattgcac   1080

agggaaagaa aaaaaataac tgcactgact ttatatcttt tgaatataat tactgtgaaa   1140

gtataaaggc tgtgttctgg aattttctgc ctcacagcaa ataaataagg tagtgaatta   1200

attattcatt ccattccact atcatgaagg actctgaata gacttggcca actgatgttt   1260

acaaaccaga cttttatatt ttaattttac agattttact acatgatttt tctaaattac   1320

tatgtcaggt tgtaaaagtc agtgcaataa caaaccttcc tttttaagaa gaaaattgtt   1380

tctattactt tcccattcac taggtaaaga atcatggaca gaacttacac tactttttac   1440

catgtttcat cttggcataa catggttctt ttttaaatag aaactttagt tttttgtaaa   1500

tttttaaaaa aatatttcat tgatatgcat ctctgcaggt cctcattcat gttgtaaatt   1560

tttgcagcaa gcagtcaaca ttccacaaac gaacaaacat tatacctctt ctgatagttt   1620

tattaagcat ggagaaattg ccaattttta aaaactgcag ttttccaaac ttttctgcca   1680

acctcttact ctgaattcag tgctgctttg ggacatatac ttgacctagc ttggtttacc   1740

agtgatggaa aagtattttg atatcattaa ctttttcaaa agatccaact ttttctctat   1800

gcctttgcca cattctcttc agggtctctt tccacagtgg ataaatgttt tttctgtatt   1860

atgacagtat tgttgtgatg gccatctgct ggaaactcct gaagagcatt atgtattaca   1920

gtgagcagtt gtattgcctg tttggtgccc aatggttaag tcattgtcac ttagctttat   1980

attgtcagtt tgatatttat tttaaattgt ggaactagat gcataaattc acatttctgc   2040

ctttcctttg catcttctca tatattgtgt tttttttttt ttttcctaga aaaaatattt   2100

aaagcattgt ttgacaggta gaaactcatg tatctgtagt ccatgagtta tatcctggct   2160

cagtggagtg atatttatgt attattttta cttttctctc agtgtcttat attaagatta   2220

acatgttgtt aatagttgct ttgttgatta atctctcttg ttggtgtttt aataaatgaa   2280

ataggcttgc ctttagatcg ggtgctgata ttgcctgttt cctagtaatg ggctgatcaa   2340

atgatcagtg gaattcttgg tttgatgata accttattaa ttgaaatttt ttactgatgt   2400

ggctttaaaa gaggtttatt ttgtatatgt ttagaactct ctgattttga tgaattatat   2460

gggaatgaga aacagaagaa gtggtatttg ctggcgagtt aaataggcaa ggtacccagt   2520

gataacacca accaaaccac tcctatctgc atgattctga acatctggat gcctgttgtt   2580

ttactgtgta tattttattt ttaatatatt aactttgtgg attcatttaa ggtctactca   2640

aaagtaacac tgtcaaaacc actaatatgt atgtaaaaat tgtgctgtat actacaataa   2700

agttgttact tggatttgtt cca                                           2723


<210>  988
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  988

Met Arg Phe Lys Asn Arg Phe Gln Arg Phe Met Asn His Arg Ala Pro 
1               5                   10                  15      


Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr Glu His Ala Ala Asn Cys 
            20                  25                  30          


Tyr Thr His Ala Phe Leu Ile Val Pro Ala Ile Val Gly Ser Ala Leu 
        35                  40                  45              


Leu His Arg Leu Ser Asp Asp Cys Trp Glu Lys Ile Thr Ala Trp Ile 
    50                  55                  60                  


Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile Val Ser Thr Val Phe His 
65                  70                  75                  80  


Ile Val Ser Trp Lys Lys Ser His Leu Arg Thr Val Glu His Cys Phe 
                85                  90                  95      


His Met Cys Asp Arg Met Val Ile Tyr Phe Phe Ile Ala Ala Ser Tyr 
            100                 105                 110         


Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met 
        115                 120                 125             


Arg Trp Phe Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe 
    130                 135                 140                 


Leu Tyr His Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr 
145                 150                 155                 160 


Met Gly Phe Ser Pro Ala Leu Val Val Thr Ser Met Asn Asn Thr Asp 
                165                 170                 175     


Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu Gly Val 
            180                 185                 190         


Val Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala Ile Trp 
        195                 200                 205             


His Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala Ile Trp 
    210                 215                 220                 


Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu 
225                 230                 235             


<210>  989
<211>  1242
<212>  DNA
<213>  Homosapiens

<400>  989
atggacagtg aagtcctcta ttgtcgcaca tgctccatga ggacctgggg atgttctcag     60

ccagcaagga ccagcgggat ggctgcttct tcctcaagca tccctcaagt ttcactcatg    120

actgtcattg aagggtttac tgagtcccgc atcacccagg gtccactgag atctccctgc    180

tcttcagctt tggggaagat ggcctcaatt ccactcatgc ttaagccctg ccctgtgaaa    240

atccaaagtc ttcctcaagt tgtctgtgaa ttcctcaaga gggcggcggc cactggaccc    300

tcgttttggc tggggaagga aaccctgaag gtgccactgg cgctctttgc cttgaaccgg    360

cagcgccggt gtgagcggct gcggaagaac cctgctgtgc aggccggctc agtagtggtc    420

ctgcagggct aagaggagac tcagcgctac tgcacctaca ccggggtcct cttccgccag    480

gagtccttct ttcactgcgc attcggtgtc accgagccag gctgctacgg cttcatcgac    540

gctgacactg ggaagtcggc cctgtttgtg cccaggcttc ctgccagcca tgccacctgg    600

atgggaaaga tccattccaa ggagcacttc aaggagaagt atgccgtgga cgacgtccag    660

gacgcagatg agattgccat tgtcctgacg tcacagaagc cctctgtcct cctcactttg    720

cgtggcgtca acacagacag cagcagcgtc tgcagggagg cttccttcga gggcatcagc    780

aagttcaaag tcaacaacac cattcttcac ccagagatcg tttagtgccg agtgtttaag    840

acggacatag agctggaggt tctgcactac accaataaaa tctccagtga gacccactgt    900

gagacccact tctccaccgt gggagaagtg atggaattct acttggagat cgaccctgtt    960

accttgaacc tgatcatcct agttgcgagc tacgtcatct tgctcctggt cttcctcatc   1020

tcctgcgtgc tatacgactg ccgaggcaag gatcccagta aggagtacgc gcccgaggcc   1080

actctcgagg cccagccctc catccgaagg gcgccgcgtt cccgcgctcc tccccttccc   1140

ctcgccccgc ccctccccag cgaggccccg cctcgctgcc cgagcccggc gggaatgaat   1200

ggcagcgtag ccgccgcgcc gctcggggtg ccgattggct ga                      1242


<210>  990
<211>  413
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (144)..(144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (275)..(275)
<223>  Xaa can be any naturally occurring amino acid

<400>  990

Met Asp Ser Glu Val Leu Tyr Cys Arg Thr Cys Ser Met Arg Thr Trp 
1               5                   10                  15      


Gly Cys Ser Gln Pro Ala Arg Thr Ser Gly Met Ala Ala Ser Ser Ser 
            20                  25                  30          


Ser Ile Pro Gln Val Ser Leu Met Thr Val Ile Glu Gly Phe Thr Glu 
        35                  40                  45              


Ser Arg Ile Thr Gln Gly Pro Leu Arg Ser Pro Cys Ser Ser Ala Leu 
    50                  55                  60                  


Gly Lys Met Ala Ser Ile Pro Leu Met Leu Lys Pro Cys Pro Val Lys 
65                  70                  75                  80  


Ile Gln Ser Leu Pro Gln Val Val Cys Glu Phe Leu Lys Arg Ala Ala 
                85                  90                  95      


Ala Thr Gly Pro Ser Phe Trp Leu Gly Lys Glu Thr Leu Lys Val Pro 
            100                 105                 110         


Leu Ala Leu Phe Ala Leu Asn Arg Gln Arg Arg Cys Glu Arg Leu Arg 
        115                 120                 125             


Lys Asn Pro Ala Val Gln Ala Gly Ser Val Val Val Leu Gln Gly Xaa 
    130                 135                 140                 


Glu Glu Thr Gln Arg Tyr Cys Thr Tyr Thr Gly Val Leu Phe Arg Gln 
145                 150                 155                 160 


Glu Ser Phe Phe His Cys Ala Phe Gly Val Thr Glu Pro Gly Cys Tyr 
                165                 170                 175     


Gly Phe Ile Asp Ala Asp Thr Gly Lys Ser Ala Leu Phe Val Pro Arg 
            180                 185                 190         


Leu Pro Ala Ser His Ala Thr Trp Met Gly Lys Ile His Ser Lys Glu 
        195                 200                 205             


His Phe Lys Glu Lys Tyr Ala Val Asp Asp Val Gln Asp Ala Asp Glu 
    210                 215                 220                 


Ile Ala Ile Val Leu Thr Ser Gln Lys Pro Ser Val Leu Leu Thr Leu 
225                 230                 235                 240 


Arg Gly Val Asn Thr Asp Ser Ser Ser Val Cys Arg Glu Ala Ser Phe 
                245                 250                 255     


Glu Gly Ile Ser Lys Phe Lys Val Asn Asn Thr Ile Leu His Pro Glu 
            260                 265                 270         


Ile Val Xaa Cys Arg Val Phe Lys Thr Asp Ile Glu Leu Glu Val Leu 
        275                 280                 285             


His Tyr Thr Asn Lys Ile Ser Ser Glu Thr His Cys Glu Thr His Phe 
    290                 295                 300                 


Ser Thr Val Gly Glu Val Met Glu Phe Tyr Leu Glu Ile Asp Pro Val 
305                 310                 315                 320 


Thr Leu Asn Leu Ile Ile Leu Val Ala Ser Tyr Val Ile Leu Leu Leu 
                325                 330                 335     


Val Phe Leu Ile Ser Cys Val Leu Tyr Asp Cys Arg Gly Lys Asp Pro 
            340                 345                 350         


Ser Lys Glu Tyr Ala Pro Glu Ala Thr Leu Glu Ala Gln Pro Ser Ile 
        355                 360                 365             


Arg Arg Ala Pro Arg Ser Arg Ala Pro Pro Leu Pro Leu Ala Pro Pro 
    370                 375                 380                 


Leu Pro Ser Glu Ala Pro Pro Arg Cys Pro Ser Pro Ala Gly Met Asn 
385                 390                 395                 400 


Gly Ser Val Ala Ala Ala Pro Leu Gly Val Pro Ile Gly 
                405                 410             


<210>  991
<211>  2076
<212>  DNA
<213>  Homosapiens

<400>  991
cacactgagg ggacagtctg gaggcttgca gtgactcaga cacagccaat tcctccccta     60

atagcactga atcacggttc cagcggccag tggtcgcccc tcgtcaaggt ctaaggctgc    120

tgcagccccg gctcccggag gccgtttccg cgcgcacacg cgcatccata cgtacagacg    180

tgctcgggat gcgggtcccg ccggcgggta cctgggcact gcgccccatc tggactgaaa    240

tggggacacc ccttcggggg tcccaggctc ctggccgtat tgttctcctt ctcctcgtga    300

taactccgca gtggaggtgg attccgtcca agacgcccaa cgtggctccg cgtagcaatc    360

agcgctgcaa tcctggcggt tacctcagcg gcggcgtctc tctctgcgcc tcacactcgc    420

agcccgcggc cctccccaac ttagggcgtt tacaaaagaa actactccag acgcgctgca    480

aagggaggcg catgtgcccg aaagctggcg atcagacggg gggggcattc tgcatgtgtg    540

atgtttctgg gggcggtggg gagtgtgtgt cggggtcggg gggcgggggg gagtcaggca    600

gaaagacagg gacaacctcc gctatgaagg atccgcgagt cctcaaatgt aagctccgtg    660

tgactaacga cctgcactga tttggagagc gggcatgtta aaggtcacgg acaattgttg    720

ctggcttcag catgaatgcc taagtgggat gtattcttca gcaatcacgt ttaagtctga    780

ttcaccgaaa agtattgacg tgcccaccat tcatttcagt acactgtgaa aatgcacaaa    840

gaaagtatcc ccaaattcag ttaattacaa agccgtaaat gtccttgtat acacatatta    900

ttacatacat gtaggtaaca acaaagatta aaatttgaag acactttaat agctttttgg    960

taggattttg gaatgaatat cagtcctgta aacctacgtt catctgcatt cttgggtcta   1020

ttttaaagta caaacttgcg ctaacaattt ccatgtgttg aaaatggaca aggtagatca   1080

ttgaatggtg atcaagactt ccaaacccct ccacataaaa ctgttcatga cttgcttcct   1140

ttttctagcc ggtttagggc cctgtcttaa gtcacccaca tgtgatttca ctcagggcat   1200

tgtctgtcta caataatatt gtgcttttaa accatttcct ttcttacacg tttatctaca   1260

gtgcatgcga aatctgagag cgtaatttga tggatgggca aagagttaag tcctggtgtc   1320

tggtgtggca gacctagaaa atggcagctg gagggccagc atcattttgt tactgacaat   1380

tgaaacgtgt tcacattgat tgtacacaag tcactggtgg ttgttcattt gtcaatgcac   1440

tattcctagc tcactccaca cacacaaaaa aggtataaaa atcaaatgtt taatacaagt   1500

ttccatacta ttcctgtaac catatttagc attgccaaca tttcaactgt tttaatagct   1560

tcaaacactt aaagtaacca ttagggatta agggcaccgt ttgcccctgg aatggcccag   1620

gagagcttct cctattttga aaggtttacg taaattatag tatttggatg gagcaaagtc   1680

agcagtatta atggttgaat attaatggtt gattttggct acttgtttta ttttagtgat   1740

atgtgatatt ttacacatgt atggggtacg tgtatttgtt acaagcgtag aatgtgtaat   1800

gatcaagtcg gggcacttag ggtactcatc agctgggata tttattgttt ctatgcgttg   1860

ggaacatttc aagttctgtc ttctatctat tttgaaatac acaatccatt gttattaact   1920

gtagtcactg tagtctgcta tcaaatatta gaactactcc ttctatctaa ctgtatgttt   1980

gtacccattc actaacttca ttccccccca ccctctattt ataattttat aacagacaat   2040

aattttggtt aatgaaataa atgggggaaa gaaagc                             2076


<210>  992
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  992

Met Arg Val Pro Pro Ala Gly Thr Trp Ala Leu Arg Pro Ile Trp Thr 
1               5                   10                  15      


Glu Met Gly Thr Pro Leu Arg Gly Ser Gln Ala Pro Gly Arg Ile Val 
            20                  25                  30          


Leu Leu Leu Leu Val Ile Thr Pro Gln Trp Arg Trp Ile Pro Ser Lys 
        35                  40                  45              


Thr Pro Asn Val Ala Pro Arg Ser Asn Gln Arg Cys Asn Pro Gly Gly 
    50                  55                  60                  


Tyr Leu Ser Gly Gly Val Ser Leu Cys Ala Ser His Ser Gln Pro Ala 
65                  70                  75                  80  


Ala Leu Pro Asn Leu Gly Arg Leu Gln Lys Lys Leu Leu Gln Thr Arg 
                85                  90                  95      


Cys Lys Gly Arg Arg Met Cys Pro Lys Ala Gly Asp Gln Thr Gly Gly 
            100                 105                 110         


Ala Phe Cys Met Cys Asp Val Ser Gly Gly Gly Gly Glu Cys Val Ser 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Glu Ser Gly Arg Lys Thr Gly Thr Thr Ser 
    130                 135                 140                 


Ala Met Lys Asp Pro Arg Val Leu Lys Cys Lys Leu Arg Val Thr Asn 
145                 150                 155                 160 


Asp Leu His 
            


<210>  993
<211>  2242
<212>  DNA
<213>  Homosapiens

<400>  993
agtgtggaaa cgcccactga ggggcacaca gtgaggcggc cactggctct gtgtccttgg     60

ggaagcccct tctgcggtcc cctccattgt ctgcgtgaca aagtggacgt agaactcccc    120

catttcctgc ccagggcggg tgaggaccct gcacacacac ggtgtgtttg tgagctgtgc    180

agagtggggt ctccctggca atggccacag cctccagggg cgctgacacc tcccgtctaa    240

ctggtagaca gtttctgcct cttcttgttt ggggattgga gagggaagtg cgtctggatg    300

actactaaga tgaggaggct gaggcctagt gctcctagcg ggcttggtca agagcaggag    360

gcggaggtgg tggaaggctg tttccctgcg gtgacagaaa ctccatttgc accagcttac    420

attaaaaaaa gaggagggag aatatggtcg agtgacccca ggagtgatag ggagcactga    480

cggagtttct ccctgctctg gatagcagat ccgctggctc ccagcttatg atccatgaag    540

agaacgtctt ccccttgggc ttcaatttga agaatcctga agacgaccct gatggccttt    600

cgcggtccac gtgccccttc ttgcactacc gtgatggtcc tatccacgga cgccttctct    660

tgggttctgt ggttggatgc ggaggaatca tcgatcctct gtagtggaag ggaagggagg    720

acacaccaag accatgtggc cccaagagcc gtgagaggag cagaagcctg actggtgcct    780

cttacatgtc actgcagcct cggggggggc caccaggaaa acacctgaca tcctgttctc    840

tagtaatggt gtggctggaa tcattcctgt accaaataat tcacccattt aaagtgtgca    900

atccaacaat gattggtata ctcagagttc tgcaactctc accacaatca attttggaac    960

atttctatca tccctagcaa taaatactat atcttttttt tgtgtgtgtg agacagagtg   1020

tcactttgtc acccaggctg gagtgcaatg gcgtgatctc tgctccctgc aacctccacc   1080

tcccgggttc aagcaattct cctgcctcag cctcccaagt agctagctgg gactacaggc   1140

acgcaccacc acacctggct aatttttgta tttttagtag agacagggtt tcatcatgtt   1200

ggccaggatg gttttgatct cctgacttca tgatccactc gcctcagcct cccaaagtgc   1260

tgggactaca ggcgtgagcc accacgcccg gccagcaaat accgtatctg actagcactt   1320

tccatttccc tccaaccccc taatggtttc ttttcccaca ataatctaaa tgtttaagga   1380

actggtttgc taactcattt cttaatgaca agaattaagc cagcacagcc tctggtttct   1440

gacattcttt ccctacaaag tcattcatca tttatccttt tttaagggac ttccttcatc   1500

tctgtgcctt aggctcactt cctgactgtg gggatcagct cctctcacca atggtgagta   1560

gggagtacct gccgttaaac ctctgtcacc acaggagaga gatgccatgg atggatgatt   1620

ttctctctga ttcttggcat tagttcattg ggcaaaaatt cagcttccag ttaagcaccg   1680

gcccatggac cgggcttggt cctgtttccc ctggaagcac tgctgggaaa ccaagcccag   1740

ccctgcaggg cttcctcctg ctgccgccca cgccaggatc agcctcctct tgccgctgca   1800

gccccgtcgc tgcaccggtt tcatcggtct gaagtccagc tgctcctcct tggcctctgc   1860

acctcagcac aggctactgc ctctgagggg ccgcccagcc gtcgtcctcc tcacaacctc   1920

ccatgatcgt ggccctgagg tcacctttcc attggcgatg aacaatccca ttgtcactcc   1980

ccatgggtgt gcccaccgga agctgctcat gggcaggagg ggaactgttc aagctggttt   2040

ttccagcccc taccacagcg ctgggtgtgt aggtggacaa gaaagtcatt acgtatgtaa   2100

atgaggaagc gcatgaacac ctgagcgtgt gagaattcgg tggggtgaat gccactccaa   2160

atgtgtgtca aatatgatgg gactgaatgc aaatgaaagt gggtcaagga gatattcaga   2220

ataaaatgag caacttttcc tc                                            2242


<210>  994
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  994

Met Asp Arg Ala Trp Ser Cys Phe Pro Trp Lys His Cys Trp Glu Thr 
1               5                   10                  15      


Lys Pro Ser Pro Ala Gly Leu Pro Pro Ala Ala Ala His Ala Arg Ile 
            20                  25                  30          


Ser Leu Leu Leu Pro Leu Gln Pro Arg Arg Cys Thr Gly Phe Ile Gly 
        35                  40                  45              


Leu Lys Ser Ser Cys Ser Ser Leu Ala Ser Ala Pro Gln His Arg Leu 
    50                  55                  60                  


Leu Pro Leu Arg Gly Arg Pro Ala Val Val Leu Leu Thr Thr Ser His 
65                  70                  75                  80  


Asp Arg Gly Pro Glu Val Thr Phe Pro Leu Ala Met Asn Asn Pro Ile 
                85                  90                  95      


Val Thr Pro His Gly Cys Ala His Arg Lys Leu Leu Met Gly Arg Arg 
            100                 105                 110         


Gly Thr Val Gln Ala Gly Phe Ser Ser Pro Tyr His Ser Ala Gly Cys 
        115                 120                 125             


Val Gly Gly Gln Glu Ser His Tyr Val Cys Lys 
    130                 135                 


<210>  995
<211>  3816
<212>  DNA
<213>  Homosapiens

<400>  995
atggacacct gtgcgcgcct cgcggcaggg gctgctgagc acgcggatgg gtcctctgga     60

ggctgggccg ccaagaggcg gcggctgcac catctgatgc tagagaacga gaaccgcagt    120

gcgtgcccga cacaaaggga aggacagggg acactggaac aggggagacg acatggaaga    180

aatctggggg agccaaaagc cgccatgccg agaagggggt cggaggaggc gcgggagaga    240

aaagcccagg gctgtacact cgcatccctc tgctgccggc ccttcggtct ttttttctgt    300

ttcctcaagt acattttctg ctatgatgct gcaaacaggc accaggatga gtcagaccca    360

tttaagattg ttgagcctca caggtttagc gatttaatta cgtgttttgt gggatttgca    420

agctgcgtgc aatctccccg cgtgcctcag gtccacaagt ggcagtggcc cttgtctctc    480

tctggttttg tttggtggta catcaggcca gtctctggaa gcccggaatt gaggatgcaa    540

gcatgttcat gcgcgtggtg taggatcgac ggggaaggaa atcgctggag accttccgct    600

ccctcctcca cctggggctg ggccgtgaaa acaataacag agtacaccag tcatcataag    660

aagaaaaatt cacatttaaa gtttggaaag caacaggaca aaggtctgtc ttcagtggtg    720

cgtagacatg ctcgtgattg aattggaaat agttctcttt ccttctctct gacttcctaa    780

ctgaaaagct gcagcgtggg gagaaaggct gctcagaagc ctggagccag aacacgcacc    840

ccggcttttg cagggccggc tcacttggtt agaatcaaag gaaaagcctt gttatttggg    900

aagctgggcg tcctcaccaa attaggggat ttaatttgca gatatctaag gagtgctttg    960

aaatgaaaga tgaactaaaa tctgctctga ggcccgtgat ttttcaccag tgaaggactc   1020

tcttgctgct ggacatacat gaaaagcatc atctgatctg aaacgcaagt ccctgcaaga   1080

cagaggagag actttataaa cattttatac cattctatga aatcaattcg attcagggct   1140

agaattcaag aagtaatcca tgggcaagta tatctgatgg taaacccaaa cgattatatt   1200

gttaacctct tgtacttttt ttaatttttt attatttgat attattatca caaaagtcgc   1260

tggaacagga tccatgagct gcttcttcac tgcttagtgt tttcagaagc tgatggatta   1320

ttaagctcca attgaatact tgatttccaa tgattccatt aatttttctg gtttgtggta   1380

ggatttgatt tacttatttt gtactttaac acaccaataa aaaatagata ctaagaaata   1440

gtgaaatttg ttgcttcaaa ataaccctta aaatttagag tttagtgaaa ttaagcaatt   1500

caaatagaga aacgattatc cttcatttcc ttaaggcaca gaaattgaga ctaggttcaa   1560

gaaccttcat attttaaaaa ctggaaaata ctggctaagt gaggactggg cggtcatcct   1620

ccacacatgc tctgtgtgct tggagcgaag aggggaacgc actgaatgag atgaactgga   1680

aggaggtgca gcagcgaagg aaatccttct gttgggagag ttcacgtgtt taggataatc   1740

cttcgaatag gacgcaacag tgatgtgagg agaagctttg gagctgattt agattgagac   1800

agtctatcac aggctgtttg gttgcatccc tttggggcca gtctcatttt aggtctaaat   1860

atgcaggaat ggggctctgg cttccagaag tttcaggctg caaaaggctg gggccaccat   1920

ctttacagat aatccattag tttgattctc ttgggggcca ggaagaaaac caagaacact   1980

caatggacta tgggactcaa ataatccaca ggaggcgttt gtaaaggggc aaaactgtgt   2040

gtgcccagta attcttggag ctcgcaatag aggtggagaa gcagtgatgg gccccacagc   2100

agcaggggct tgggaatgac ggaaaagaac aaaatgatgg aaggacagct ggaagaaaca   2160

gggaagcttc cttttaactg gatgctgggt ctcagccttg aatagttcct ggccttcgga   2220

ggccttttct cagggagcat ggcctgggga ctccctgctt gctctgctga gctttcaggg   2280

aaggagaaat gggcaaggcc agaggcgacc atcaggtgct ccgtaggcac agaggcagaa   2340

ctcaaggttt agctttacct taagagggtg actgcaaagt gtgctccctg gaccaggggc   2400

ctcggcctca cctgggagct tgctaaaaat gcaagttgct ctcacccaga ctgaatctaa   2460

aattctgggt acagcccagc aatctctgct cacactttct ccagatgatt ctggtgcaag   2520

ctaacctttc aaaagtcctg ggtcccattc ccagaggctg tgattaagtt ggtctagggc   2580

tgtggcctag acctggggat tttggaagcc cacaggtgat tctgttgtgc agccatggtt   2640

ggcaggctgt tcacggtgct gttcaacagg tcctgctgtg ggatggaaag ggtctgtatc   2700

tgcactggcc aatgtgggag ccagccctgt ggctattgag cacttggccc ctggctagtg   2760

caactgagga gctgaatttt tcatttcatt tacttttaat taagtttaaa tagctaaatg   2820

tggctattgt ctgccttatt ggatagcaga gttctagaac cacagataaa tgtaatactg   2880

tccctttagt tgatttaaaa atccaatgcc tctgtaatcc tagcactttg ggaggccaag   2940

gtgggctgat cacgaggtca agagatcgag accattcttg ccaacatggt gaaaccccgt   3000

ctctactaaa aatacaaaaa ttagccgggc atggtggcag gcacctgtaa tcccagctac   3060

tcgggaggct gaggcaggag aatcacttga acccacgagg cggagcttgc agtgagccaa   3120

gattgcacca ctgcactcca gcctggtgac agacggagat tctgtctcaa aaaaaaatgc   3180

ctcacagagt taaatattta agttgataag aaaaatggta gtcgagtctt tgaggattat   3240

tttaaaatcc acttttggtg ataaatagat aaaaacagtg tggtagggcc cagaagttct   3300

tcctgatttc tacctgttgg agctgaattc ctcaatttta cttgtaggag aacggcttcc   3360

taaagggcac cttacccagc cattcctgca tgcaagtgtg tatgagaact gcagggggca   3420

ttatatgaaa atccaattcc tgggctctat cccagatgtt cctatccaat aggtctgggt   3480

tggggccctg gaaactgcat ttttggcaaa ccccttactg atttggatgc acaagtttca   3540

aggaacaggc actaaggatc gctgatgtag aatctgtttg tccatccagg aaagccagag   3600

tcaccacact tgagtaaatg ggttttgatg taggaaaggt ctttataatt ctttcatgaa   3660

ttcaccaaac tttaaaaact gtactatttt tggctgggct tggtggctca cgcctgtaat   3720

ctcagcactt tgggggccaa ggcgggtgga tcatgaggtc aggagatcga gaccatcctg   3780

gctaacacgg tgaaaacctg tctctacgaa aaatac                             3816


<210>  996
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  996

Met Asp Thr Cys Ala Arg Leu Ala Ala Gly Ala Ala Glu His Ala Asp 
1               5                   10                  15      


Gly Ser Ser Gly Gly Trp Ala Ala Lys Arg Arg Arg Leu His His Leu 
            20                  25                  30          


Met Leu Glu Asn Glu Asn Arg Ser Ala Cys Pro Thr Gln Arg Glu Gly 
        35                  40                  45              


Gln Gly Thr Leu Glu Gln Gly Arg Arg His Gly Arg Asn Leu Gly Glu 
    50                  55                  60                  


Pro Lys Ala Ala Met Pro Arg Arg Gly Ser Glu Glu Ala Arg Glu Arg 
65                  70                  75                  80  


Lys Ala Gln Gly Cys Thr Leu Ala Ser Leu Cys Cys Arg Pro Phe Gly 
                85                  90                  95      


Leu Phe Phe Cys Phe Leu Lys Tyr Ile Phe Cys Tyr Asp Ala Ala Asn 
            100                 105                 110         


Arg His Gln Asp Glu Ser Asp Pro Phe Lys Ile Val Glu Pro His Arg 
        115                 120                 125             


Phe Ser Asp Leu Ile Thr Cys Phe Val Gly Phe Ala Ser Cys Val Gln 
    130                 135                 140                 


Ser Pro Arg Val Pro Gln Val His Lys Trp Gln Trp Pro Leu Ser Leu 
145                 150                 155                 160 


Ser Gly Phe Val Trp Trp Tyr Ile Arg Pro Val Ser Gly Ser Pro Glu 
                165                 170                 175     


Leu Arg Met Gln Ala Cys Ser Cys Ala Trp Cys Arg Ile Asp Gly Glu 
            180                 185                 190         


Gly Asn Arg Trp Arg Pro Ser Ala Pro Ser Ser Thr Trp Gly Trp Ala 
        195                 200                 205             


Val Lys Thr Ile Thr Glu Tyr Thr Ser His His Lys Lys Lys Asn Ser 
    210                 215                 220                 


His Leu Lys Phe Gly Lys Gln Gln Asp Lys Gly Leu Ser Ser Val Val 
225                 230                 235                 240 


Arg Arg His Ala Arg Asp 
                245     


<210>  997
<211>  2337
<212>  DNA
<213>  Homosapiens

<400>  997
agcttcggat gcatcagaca caaacgctgg ataaagctgc tcattcacat aaagcaccac     60

ctgctgccgc tacctggaat atccacactg gataactcga agcttggtgg aaacagaggt    120

tggaaaaagc agaaaataaa acaaagggat ggaagatggg tgctctgaat tccatttcct    180

tagaaaccaa caagagctcc ttcagtatgt cgtggacacc ttcagttgag cacagctcag    240

gcaccgcaag gacactccgc tcatgtaagt tggccttagt aggtttttct tccatgagtg    300

aatttctatt cagagcaagt aaaacacagc ctgtgacact gtttgtcccg aatgtcaaca    360

gcgctctctg tgatcagccc gttgtacgag gtgttggaat acatgaacaa cgcaaacgga    420

atatctcgtc tctcatttct gtctttaatc attggctgcc tccactccag ttacacctgg    480

gccgtgctct gatctgcagg tttaactcca ggggaaactt cacctgtttg atgacagccg    540

tcaagtgaac cagatgttac ctctagtaag aaaggatggg caggtagagt gtgatgtctg    600

gggtgctcct gactcagggc ggcctccctg gctcccctca cccagttgga cctgggtgcc    660

cttgtcctac tcttctatag catccttggc ttttccttca tggtgcccat cacacattcc    720

agcgagacac ggatttgtgg gattatttgc accgggtgaa gttggcctgt tccactagtt    780

tcctgactcc aggagctcag agcttttgtc attctttctt cactctgtgc atgtaacaca    840

caagagacgt ttcctgaatg aagggcccct gatgctgtgg cacaaataac aaaacattgg    900

gaagtagtac gtcttgccag ccctactgct ggccctgaat gactggaacc agtgcttcaa    960

ttttaaacat ttgattgaca agttattttc agcagtttgc cctcaaaaga tgaccttgtg   1020

tcgtttactt ctaacctgat ctgggcttag cgtatctact cattccttag gtcagccaca   1080

gcctcataag cagctacgtt caatcagtcg tcacagccct gggcacagac ttctcagcaa   1140

gagtaatttt ctcacttatg ctaacaattt gacttcttca aacgcgtact cttttttttt   1200

tttttttttt ttttttgaga cggtgtctca ttatgttgcc cgggctggac ttgaactcct   1260

gggctcaagc aatcctcctg cctcagcctc cagactagct gggacataga tgcatgtcac   1320

cgtgcccagc tcaaaagcgt acttttacct acactgatga tatcaagaca tgatagaaca   1380

aaaagcatat ttcctgagtg attttttaaa aatttcaacc gcctgtacac agactgtaac   1440

accagcagtc gtgaggaagt gcttgggact tgccggttct cagacttgcc tcttgccagg   1500

gaggagaccc catctaataa caaatgtctt tccctaatga agtccagaac cagatctttc   1560

atggacctag attttacctg cagagatgtg gaacagccac agttggaaaa ccatgagtgc   1620

ttgatgttaa atgaaggcaa cactcctcaa ttctgagatt gtttatattg ttttgggaat   1680

gtaatcgttg gagaaaacat ttctcagcct ggtcacaaac cgtccctccc acaacaacaa   1740

caatggagta taagaagtac agttttacag agtattttgg gggctttctt ctcatgacaa   1800

gagtctttct tatggtacaa atagttgtgt cctttctcac agcataaaat atacacataa   1860

aatagtaaaa cgggagagac agtactgaca gtggatgaag ccaggctgac gtgactgaga   1920

ggcaagtttc aacatcagga aaaaaaacaa agaccacact tactcctcag gagatacatg   1980

ggtgatcttt caagagacca tcagaaagag gctgcttggg tcccgtccga ggagagacag   2040

aagactgagc cgtggtgtac tctattatct gacgcaacag ccttttctgc aggatattaa   2100

aggactttat aaatattaat tatctcattc atcctcatca ctttgtgaga gccgaagaca   2160

ttatagatgg ccagtcaccc atttcactaa gtatctaaag ccaccttcca cacgtaatca   2220

ttaacatttc aaaatacttt cacctcttta ttattcagag atgttgagtt tatgaaggac   2280

tcggtccttt ttggttcttt ctgccccgca ttaataaaca cctttgaatt actaaac      2337


<210>  998
<211>  130
<212>  PRT
<213>  Homosapiens

<400>  998

Met Gly Ala Leu Asn Ser Ile Ser Leu Glu Thr Asn Lys Ser Ser Phe 
1               5                   10                  15      


Ser Met Ser Trp Thr Pro Ser Val Glu His Ser Ser Gly Thr Ala Arg 
            20                  25                  30          


Thr Leu Arg Ser Cys Lys Leu Ala Leu Val Gly Phe Ser Ser Met Ser 
        35                  40                  45              


Glu Phe Leu Phe Arg Ala Ser Lys Thr Gln Pro Val Thr Leu Phe Val 
    50                  55                  60                  


Pro Asn Val Asn Ser Ala Leu Cys Asp Gln Pro Val Val Arg Gly Val 
65                  70                  75                  80  


Gly Ile His Glu Gln Arg Lys Arg Asn Ile Ser Ser Leu Ile Ser Val 
                85                  90                  95      


Phe Asn His Trp Leu Pro Pro Leu Gln Leu His Leu Gly Arg Ala Leu 
            100                 105                 110         


Ile Cys Arg Phe Asn Ser Arg Gly Asn Phe Thr Cys Leu Met Thr Ala 
        115                 120                 125             


Val Lys 
    130 


<210>  999
<211>  2584
<212>  DNA
<213>  Homosapiens

<400>  999
gcttcttccc agtctgcacg gctcgagacg gccgctcatc cctgctcccc gtgtgtccct     60

cggtcctctc tgcagctccc agccctcaac tccttacccc agtttgggca accagctgcc    120

ccgctgtttg gcccaggcct gggccatgac ggatgggtgg gcgcccgggg ccgcgagaag    180

ggcggaacgc tgtgcccagc cggagactac gctgggtggc ggcggcagcg ccgggagtct    240

gcagtgcgcg agggagaagt gagcgcacag cgcccagcga gcaggtgcct gcggcgcgga    300

gagcgcacac gctagccagc ccgcagcggc cgaaagtgac cactgttcct ggaggatttg    360

cattgctgga gaagtgcatt ctaacagtgg aattcaggcg gcgagagtcg gtcaattcac    420

cgtaccatgt ggactcccca gtgtggagca gaatctgagg actgacttgc taagaatctc    480

tgggcaccct ggatagaacc ttccctttgg ctctgagcat ggtggctcac acctgagatc    540

ccagcacttc ggaaggccga ggtgggagaa ttgcttgagg ccaggagttc gagaccagcc    600

tagttcctgg atgcaaacct tgagaaatca acttggagaa cgagctaagt ttccgttgtc    660

cagagctcag gtgctgggac aggtggcacc cagatcttcc agccatatgt ggagtcgctg    720

gtggagtctt atctctctct ccagagtgtg tccctgcagt ggaggctggc ctttcatctc    780

agcaccaggg tgcccagggc ccagttgatc caggaagttt gttgaatgaa tgagtgattg    840

gcacattctg ggcaggagac tgtctggccc agaagaatgc ctggtttccc tcagggcagg    900

gcactcccct gtgcagacag gcgggcatgg agcagaaaca gccagggtgg acgagctttt    960

cagcagcatg aaggcaacag ccgatttgtt cacagtcgag agtgaaggaa tgaatttacg   1020

agaacctgca tgaactatgt gatcatagtg ttggtggtca gactgtgagg cacaggaaga   1080

tggatcagag ggtcaaaggg gcaccatcta cagctcattt ccccgtcctc caaccaatgg   1140

gcctgcccca gacctgctcc cctgtccctg gggaggagga ggatattcca gactcacgga   1200

cctgaacctc tctgggcata tgtccagtct ctgtcctgca gagatgcctt gggcctccca   1260

tttcaacagc atccttcccc tgatgtggga aagaatttcc taatcgccct cacctctggc   1320

ttcaggtcca tgcaacacaa gccctgtttc gggcctcctg tgttcaggct cctgagcacg   1380

gcttcccttt ttgaaaccag ggaggctggt gttgcctgca gaagcatctt gtgagttgtg   1440

ggaggggcca catggaaggc cagacatggg agtgaagtgt gaagcaccag ccttcctgac   1500

ttccagaccc aggtcagcct cccgcctctc ctcctgctga atctttctga tcctgcggtt   1560

tctcctctct gaaacgggga tgctgatggt tccataatca aagtcctgtg ctgattcatt   1620

gcaatgatga ctgtttagcc ccagctgcag gaaaaaaaac cgaacagaac aaaactagac   1680

cgggtatggt agctcacgcc tgttaagtcc agcactttgg gaggctgagg caggaggatc   1740

acttgaggcc aggagtttgg gaccagcccg ggcaacatag caagacccct atctctacaa   1800

acaacaacaa tagcagcagc aaaatcccac taaaataata aaatgctcac tgtaagcaga   1860

gagtacttct ctgccctact gacttgctcc tcctactgag caggccacgt gacttgctcc   1920

aacgaatgga atgtgtgcag atatgtatgt cacatccagc cagaggcttt caatatgatt   1980

gaacctggac tcttgccctc ttgccttgca cttggagaag aatgtgctcc aggatgcttc   2040

agtagaaagt ggaaatgctg tctcccgaat ttgctgaacg atgatgttct gaggagacct   2100

gcacttgaga acaaaagtga ctactctttt gtcctaatct taaatcccat caccttggct   2160

gcaactgctg agtgctggta atgagtgttg agaggcaatc cgaggatggt gattaggtat   2220

taagcctggg caggtattaa ccgagaggtg tgtggacctt tcgctcagca ccacaagagc   2280

agatctctgc cagcaagctt atctggccat cagccaggga cagagctgca ctgtggcaaa   2340

gtgaaatgtg attttaatga ttctgagcac atggtttctg cctccagcat gctagatttg   2400

tagactggca ttttttttcc cttgggtaga ttccagatgt tgtataactt gtgcctttct   2460

aagttacagc atggtagatg gggacttgtc tttgttatga gcatgtacaa tgtgggtcgc   2520

agttaagcac tgtcaaatag cctcctaaaa gatgagtttg tgtggaataa agcactgaaa   2580

aagg                                                                2584


<210>  1000
<211>  101
<212>  PRT
<213>  Homosapiens

<400>  1000

Met Gly Gly Arg Pro Gly Pro Arg Glu Gly Arg Asn Ala Val Pro Ser 
1               5                   10                  15      


Arg Arg Leu Arg Trp Val Ala Ala Ala Ala Pro Gly Val Cys Ser Ala 
            20                  25                  30          


Arg Gly Arg Ser Glu Arg Thr Ala Pro Ser Glu Gln Val Pro Ala Ala 
        35                  40                  45              


Arg Arg Ala His Thr Leu Ala Ser Pro Gln Arg Pro Lys Val Thr Thr 
    50                  55                  60                  


Val Pro Gly Gly Phe Ala Leu Leu Glu Lys Cys Ile Leu Thr Val Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Glu Ser Val Asn Ser Pro Tyr His Val Asp Ser Pro 
                85                  90                  95      


Val Trp Ser Arg Ile 
            100     


<210>  1001
<211>  2114
<212>  DNA
<213>  Homosapiens

<400>  1001
atggaacagc ggaaccggct cggtgccctc ggatacctgc cgcctctgct gctgcatgcc     60

ctgctgctct tcgtggccga cggtgagcgc gggaactttg ctgccgctgt ggactcgggg    120

gggtctttgc tggggccgcc accgagaaga agaagaaaga gaacgaaccg ggaagcttcg    180

cggtctccag caatcccgct gtgcagcctg ggcccggagg gccaggctct ggcggtgcgg    240

ccaggggcgg gggagaagca cgagtcgccc ctgccgcccc gccccatccg gagggaagca    300

gtaggcagcc gatggccggt ccctgcctcg gccctgcagc cgcttccccg aactttgcta    360

gcccctccgg ccgtgcgcca gggagcagct gcggggtggg gggcacaagg ccagccagcc    420

agagaccgac tgcctcgctt taggttgccc caggcccccg acctacagct ggtcacgcct    480

ctctctctct ccccaccccc agctgcattc acagaagtcc ccaaagatgt gacagtacgg    540

gagggagacg acatcgaaat gccctgcgcg ttccgggcca gcggagccac ctcgtattcg    600

ctggagattc agtggtggta cctcaaggag ccaccccggg agctgctgca cgagctggcg    660

ctcagcgtgc cgggcgcccg gagcaaggct ctccccgccc tctgccactt tgaggacccc    720

agggctccca cggctgcgtt ccagaggcca ccagaaaacc gagtaccgga aagccggcag    780

gacctccagc cctcaggggc acagaggggc cacttctctg tggccgaaaa caggcccacg    840

ctgcctgtaa caaataagga tgcaactaaa atcagcgtaa gtgtggagcc cagcgcgggc    900

cgcgggagac cccttctggc cgcctcgggt cccgcagctc cctcccttag caagccgcgg    960

cggccgcgca tgtggggccg cgcaaggcct ctcgcgcctg ccagcctccg ctctgcgggc   1020

attcctccta gcaccgggag cgcgcggctg ctcgccctcg ccgcgaccgt ggcgccagct   1080

tcccgccccc tctgccccgc cctgagcatc tgctctgcgc cctccgctgc aaccctttat   1140

cctccgcctg gattgcgggt ctggaccgta cgcgtccagg gcaatgacat ctcacaccgg   1200

cttcggctgt ctgccgtgcg gctgcaggac gagggcgtgt acgagtgccg cgtgtcggac   1260

tacagcgacg acgacacgca ggagcacaag gcccaggcga tgctgcgcgt gctctcgcgc   1320

ttcgcgccgc ccaacatgca ggccgccgag gccgtgtccc acatccagag cagcggcccg   1380

cgtcgccacg gcccagccag cgccgccaac gccaacaacg cgggcgccgc gagccgtacc   1440

acctccgagc ccggccgcgg cgacaagagc ccgccgcccg ggagccctcc cgccgccatc   1500

gatcccgcag tccccgaggc cgcggcagcc tcggcggccc acacgcccac caccacagtc   1560

gcggcagctg ctgctgcctc gtcagcgtcg ccgccatcgg gacaggcggt cctgctgcgc   1620

cagaggcacg gctcgggcac cggccgtagc tacaccacag acccactctt gtccctgctc   1680

ctgttagctc tgcataagtt cctgcgcctg ctcttgggac attgacagac aagaccaacc   1740

cgagcatctc agaggccgca catgacctgc ccggggccct cggtgaggac catgtcgctg   1800

gatggacaca gagagactga gagacgcatg aaaaagtcca catggaaaat aaataaatca   1860

tatttttggg aaagttacac aaatgtagaa cacctaaaat aatgcatcta gtttccaaat   1920

aatttggagt ttggcccatg cagtctgcat gggaatcaat gatttctcta cttcaatgta   1980

gttttctttt ctacactttc cctccaagtc ttcattttgc acgaactgtt gagcagttat   2040

ctttaggata atatgtacaa atgttggggt caaagccttt tgacaaagca aaatattttt   2100

agtagattat tgtg                                                     2114


<210>  1002
<211>  574
<212>  PRT
<213>  Homosapiens

<400>  1002

Met Glu Gln Arg Asn Arg Leu Gly Ala Leu Gly Tyr Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu His Ala Leu Leu Leu Phe Val Ala Asp Gly Glu Arg Gly Asn 
            20                  25                  30          


Phe Ala Ala Ala Val Asp Ser Gly Gly Ser Leu Leu Gly Pro Pro Pro 
        35                  40                  45              


Arg Arg Arg Arg Lys Arg Thr Asn Arg Glu Ala Ser Arg Ser Pro Ala 
    50                  55                  60                  


Ile Pro Leu Cys Ser Leu Gly Pro Glu Gly Gln Ala Leu Ala Val Arg 
65                  70                  75                  80  


Pro Gly Ala Gly Glu Lys His Glu Ser Pro Leu Pro Pro Arg Pro Ile 
                85                  90                  95      


Arg Arg Glu Ala Val Gly Ser Arg Trp Pro Val Pro Ala Ser Ala Leu 
            100                 105                 110         


Gln Pro Leu Pro Arg Thr Leu Leu Ala Pro Pro Ala Val Arg Gln Gly 
        115                 120                 125             


Ala Ala Ala Gly Trp Gly Ala Gln Gly Gln Pro Ala Arg Asp Arg Leu 
    130                 135                 140                 


Pro Arg Phe Arg Leu Pro Gln Ala Pro Asp Leu Gln Leu Val Thr Pro 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Pro Pro Ala Ala Phe Thr Glu Val Pro Lys Asp 
                165                 170                 175     


Val Thr Val Arg Glu Gly Asp Asp Ile Glu Met Pro Cys Ala Phe Arg 
            180                 185                 190         


Ala Ser Gly Ala Thr Ser Tyr Ser Leu Glu Ile Gln Trp Trp Tyr Leu 
        195                 200                 205             


Lys Glu Pro Pro Arg Glu Leu Leu His Glu Leu Ala Leu Ser Val Pro 
    210                 215                 220                 


Gly Ala Arg Ser Lys Ala Leu Pro Ala Leu Cys His Phe Glu Asp Pro 
225                 230                 235                 240 


Arg Ala Pro Thr Ala Ala Phe Gln Arg Pro Pro Glu Asn Arg Val Pro 
                245                 250                 255     


Glu Ser Arg Gln Asp Leu Gln Pro Ser Gly Ala Gln Arg Gly His Phe 
            260                 265                 270         


Ser Val Ala Glu Asn Arg Pro Thr Leu Pro Val Thr Asn Lys Asp Ala 
        275                 280                 285             


Thr Lys Ile Ser Val Ser Val Glu Pro Ser Ala Gly Arg Gly Arg Pro 
    290                 295                 300                 


Leu Leu Ala Ala Ser Gly Pro Ala Ala Pro Ser Leu Ser Lys Pro Arg 
305                 310                 315                 320 


Arg Pro Arg Met Trp Gly Arg Ala Arg Pro Leu Ala Pro Ala Ser Leu 
                325                 330                 335     


Arg Ser Ala Gly Ile Pro Pro Ser Thr Gly Ser Ala Arg Leu Leu Ala 
            340                 345                 350         


Leu Ala Ala Thr Val Ala Pro Ala Ser Arg Pro Leu Cys Pro Ala Leu 
        355                 360                 365             


Ser Ile Cys Ser Ala Pro Ser Ala Ala Thr Leu Tyr Pro Pro Pro Gly 
    370                 375                 380                 


Leu Arg Val Trp Thr Val Arg Val Gln Gly Asn Asp Ile Ser His Arg 
385                 390                 395                 400 


Leu Arg Leu Ser Ala Val Arg Leu Gln Asp Glu Gly Val Tyr Glu Cys 
                405                 410                 415     


Arg Val Ser Asp Tyr Ser Asp Asp Asp Thr Gln Glu His Lys Ala Gln 
            420                 425                 430         


Ala Met Leu Arg Val Leu Ser Arg Phe Ala Pro Pro Asn Met Gln Ala 
        435                 440                 445             


Ala Glu Ala Val Ser His Ile Gln Ser Ser Gly Pro Arg Arg His Gly 
    450                 455                 460                 


Pro Ala Ser Ala Ala Asn Ala Asn Asn Ala Gly Ala Ala Ser Arg Thr 
465                 470                 475                 480 


Thr Ser Glu Pro Gly Arg Gly Asp Lys Ser Pro Pro Pro Gly Ser Pro 
                485                 490                 495     


Pro Ala Ala Ile Asp Pro Ala Val Pro Glu Ala Ala Ala Ala Ser Ala 
            500                 505                 510         


Ala His Thr Pro Thr Thr Thr Val Ala Ala Ala Ala Ala Ala Ser Ser 
        515                 520                 525             


Ala Ser Pro Pro Ser Gly Gln Ala Val Leu Leu Arg Gln Arg His Gly 
    530                 535                 540                 


Ser Gly Thr Gly Arg Ser Tyr Thr Thr Asp Pro Leu Leu Ser Leu Leu 
545                 550                 555                 560 


Leu Leu Ala Leu His Lys Phe Leu Arg Leu Leu Leu Gly His 
                565                 570                 


<210>  1003
<211>  1133
<212>  DNA
<213>  Homosapiens

<400>  1003
agagagcgcc ggaagcggtc cgagaatgaa gagtgtgatc taccatgcat tgtctcagaa     60

agaggcgaat gactccgatg tccagccttc aggagcacag cgggccgagg ccttcgtgag    120

ggccttcctg aagcgcagca cgccccgcat gagcccgcag gcccgcgagg accagctgca    180

gcgcaaggcg gtggtcctgg agtacttcac ccgccacaag cgcaaggaga agaagaagaa    240

agccaaaggc ctctctgcca ggcaaaggag ggagctgcgg ctctttgaca ttaaaccaga    300

gcagcagaga tacagccttt tcctccctct ccatgaactc tggaaacagt acatcaggga    360

cctgtgcagt gggctcaagc cagacacgca gccacagatg attcaggcca agctcttaaa    420

ggcagatctt cacggggcta ttatttcagt gacaaaatcc aaatgcccct cttatgtggg    480

tattacagga atccttctac aggaaacaaa gcacattttc aaaattatca ccaaagaaga    540

ccgcctgaaa gttatcccca agctaaactg cgtgttcact gtggaaaccg atggctttat    600

ttcctacatt tacgggagca aattccagct tcggtcaagt gaacggtctg cgaagaagtt    660

caaagcgaag ggaacgattg acctgtgaat tctttgccgt ctaaggcagt tgtttatgac    720

agctgaaaac tggacactcc ctaaatgtcc acctttcagt gaagagatag ttaagccaat    780

tccatttata gaccacctcc agccagtgac gctccgagtt gaggatgttg aacaacatgg    840

gaaggtcgca gcgtactaag tgaagaagtc agaggacaga ggaatttctc tttctaggag    900

attttcattt tgtgtgactc ccatggggag gaacagactg gcaggaagca caccggggtt    960

aacactggtt gacttgaata ggattattcg atttttaaaa atacttttcc atgttttctg   1020

agtgctctat gataaatcag ttgcatctgt gataatacaa tacatatgtg gacataaaca   1080

gggatcaaat aaaggaggta ttgctgcaaa aaaaaaaaaa aaaaaaaaaa aaa          1133


<210>  1004
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  1004

Met Lys Ser Val Ile Tyr His Ala Leu Ser Gln Lys Glu Ala Asn Asp 
1               5                   10                  15      


Ser Asp Val Gln Pro Ser Gly Ala Gln Arg Ala Glu Ala Phe Val Arg 
            20                  25                  30          


Ala Phe Leu Lys Arg Ser Thr Pro Arg Met Ser Pro Gln Ala Arg Glu 
        35                  40                  45              


Asp Gln Leu Gln Arg Lys Ala Val Val Leu Glu Tyr Phe Thr Arg His 
    50                  55                  60                  


Lys Arg Lys Glu Lys Lys Lys Lys Ala Lys Gly Leu Ser Ala Arg Gln 
65                  70                  75                  80  


Arg Arg Glu Leu Arg Leu Phe Asp Ile Lys Pro Glu Gln Gln Arg Tyr 
                85                  90                  95      


Ser Leu Phe Leu Pro Leu His Glu Leu Trp Lys Gln Tyr Ile Arg Asp 
            100                 105                 110         


Leu Cys Ser Gly Leu Lys Pro Asp Thr Gln Pro Gln Met Ile Gln Ala 
        115                 120                 125             


Lys Leu Leu Lys Ala Asp Leu His Gly Ala Ile Ile Ser Val Thr Lys 
    130                 135                 140                 


Ser Lys Cys Pro Ser Tyr Val Gly Ile Thr Gly Ile Leu Leu Gln Glu 
145                 150                 155                 160 


Thr Lys His Ile Phe Lys Ile Ile Thr Lys Glu Asp Arg Leu Lys Val 
                165                 170                 175     


Ile Pro Lys Leu Asn Cys Val Phe Thr Val Glu Thr Asp Gly Phe Ile 
            180                 185                 190         


Ser Tyr Ile Tyr Gly Ser Lys Phe Gln Leu Arg Ser Ser Glu Arg Ser 
        195                 200                 205             


Ala Lys Lys Phe Lys Ala Lys Gly Thr Ile Asp Leu 
    210                 215                 220 


<210>  1005
<211>  2094
<212>  DNA
<213>  Homosapiens

<400>  1005
tgaccgctga gggtgactgt gctgtgaggc ccgccggagg caccagaagg cacaagcctc     60

ccactgcccc tttccccgcc aagtcccgca ggtctcgcag tcgcgggcgc ccccacccca    120

cccctgccca aggccagggt cgcagtccca ccgggtgacg gcagtcgcgc tccgcgtggg    180

gcagcggcga gcggaaaggg aagccgggcg gggccagggg gtcaaacacg ggcgacagtc    240

ccgcccagcc ccggacctgc agcgcgcaca agctcgggcg ccctccgagc gccgcgccca    300

agccccgccc ctcccgcttc ccgggctccg attggccgag ccaccgcggg ggcgtgtccg    360

gcggagctgg ccgggacccg ggcggagcgg gcggggaccc gggctactgc ggtgtggact    420

cgagggctgg gcgcggggcc ggcgcagaag ccgccagctg gagacgatgg tggaccactt    480

ggccaacacg gagatcaaca gccagcgcat cgcggcagtg gagagctgct tcggggcctc    540

ggggcagccg ctggcgctgc caggccgagt gctgctgggc gagggcgtgc tgaccaaaga    600

gtgccgcaag aaggccaagc cgcgcatctt cttcctcttt aacgacatcc tggtgtatgg    660

cagcatcgtg ctcaacaagc gcaagtaccg cagccagcac atcatccccc tggaggaggt    720

cacactggag ctgttgccgg agacgctgca ggccaagaac cgctggatga tcaagacggc    780

caagaagtcc tttgtggtgt cggccgcctc cgctacggag cgccaggaat ggattagcca    840

catcgaggag tgcgtgcggc ggcaactgaa ggccacgggc cgcccgccca gcacggagca    900

cgcggcaccc tggatccccg acaaggccac ggacatctgc atgcgctgca cgcagacgcg    960

cttctctgcc ctcacgaggc gccaccactg ccgcaagtgc ggcttcgtgg tctgcgctga   1020

gtgctcgcgc cagcgcttcc tgctcccgcg cctgtccccc aagcccgtgc gcgtctgcag   1080

cctctgctac cgcgaactgg ccgcccagca gcggcaggag gaggcggagg agcagggcgc   1140

ggggtcccca aggcagccag cccacctggc ccggcccatc tgcggagcgt ccagtggaga   1200

tgacgatgac tccgacgagg acaaggaggg cagcagggac ggggactggc ccagcagcgt   1260

ggagttctac gcctcggggg tggcctggtc tgctttccac agctgacccc gggcctgcag   1320

aacatctgtc cccaagccag ctccactgcc caggccccca agagggcagc tccagaagct   1380

gcccagggct ccgggacccc atcccatggt ggcaggtgca gcggtgggga gtggctcttt   1440

ctggactccc agtgcctttt tgctggacac tgtgtcctta tggcttcact gcaggtaatg   1500

cctttccctt caggaagccc cagaacaccc acaggtcttg gtaacaaacg ccaccttaca   1560

ctctgcaggc tgcagcggca gctccagatg gcctcctgag ctggacgacc ccaggtctcc   1620

agacatctag ggaccagagc aggtttggga acacagaggg aagacaggat gggagtgtag   1680

ccacagaacc cacctgcacc ctgacaggca caccccactg aagagcctga gtcccaggag   1740

gcctcctgga agcccaggac tgcccaccca ccacgctggt gcccaccgcc ttggccagcc   1800

aagccctgcc gatcagacat gtgggctccc cgaagcccag ccagagactg ccgtgctgtg   1860

ggtgccacca ggcccaggga ctgcagcctg agctccccga ggcccagggc agccgggtga   1920

ggactctgtc ctgtgtcacc tctctccagg tgtccagctg tctcatgcct ttttgtcctg   1980

tcctcagctc tccgtgtggt cagcgaaacc attgttttct gttaggactc agttgcaaga   2040

acagaaaccc tgccccccct taataataaa aaagaaagtt tattggaaaa aaaa         2094


<210>  1006
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  1006

Met Val Asp His Leu Ala Asn Thr Glu Ile Asn Ser Gln Arg Ile Ala 
1               5                   10                  15      


Ala Val Glu Ser Cys Phe Gly Ala Ser Gly Gln Pro Leu Ala Leu Pro 
            20                  25                  30          


Gly Arg Val Leu Leu Gly Glu Gly Val Leu Thr Lys Glu Cys Arg Lys 
        35                  40                  45              


Lys Ala Lys Pro Arg Ile Phe Phe Leu Phe Asn Asp Ile Leu Val Tyr 
    50                  55                  60                  


Gly Ser Ile Val Leu Asn Lys Arg Lys Tyr Arg Ser Gln His Ile Ile 
65                  70                  75                  80  


Pro Leu Glu Glu Val Thr Leu Glu Leu Leu Pro Glu Thr Leu Gln Ala 
                85                  90                  95      


Lys Asn Arg Trp Met Ile Lys Thr Ala Lys Lys Ser Phe Val Val Ser 
            100                 105                 110         


Ala Ala Ser Ala Thr Glu Arg Gln Glu Trp Ile Ser His Ile Glu Glu 
        115                 120                 125             


Cys Val Arg Arg Gln Leu Lys Ala Thr Gly Arg Pro Pro Ser Thr Glu 
    130                 135                 140                 


His Ala Ala Pro Trp Ile Pro Asp Lys Ala Thr Asp Ile Cys Met Arg 
145                 150                 155                 160 


Cys Thr Gln Thr Arg Phe Ser Ala Leu Thr Arg Arg His His Cys Arg 
                165                 170                 175     


Lys Cys Gly Phe Val Val Cys Ala Glu Cys Ser Arg Gln Arg Phe Leu 
            180                 185                 190         


Leu Pro Arg Leu Ser Pro Lys Pro Val Arg Val Cys Ser Leu Cys Tyr 
        195                 200                 205             


Arg Glu Leu Ala Ala Gln Gln Arg Gln Glu Glu Ala Glu Glu Gln Gly 
    210                 215                 220                 


Ala Gly Ser Pro Arg Gln Pro Ala His Leu Ala Arg Pro Ile Cys Gly 
225                 230                 235                 240 


Ala Ser Ser Gly Asp Asp Asp Asp Ser Asp Glu Asp Lys Glu Gly Ser 
                245                 250                 255     


Arg Asp Gly Asp Trp Pro Ser Ser Val Glu Phe Tyr Ala Ser Gly Val 
            260                 265                 270         


Ala Trp Ser Ala Phe His Ser 
        275                 


<210>  1007
<211>  1506
<212>  DNA
<213>  Homosapiens

<400>  1007
gcggggctgg ggagctgggc ggggagcccg gggcctgcca ggcccgggct gcagccgcgt     60

ctgatcgccg agcgcgccgc gtagacctcc gctcccccag gcccgccacg atgactatca    120

tggtggagga catcatgaag ctgctgtgct ccctttctgg ggagaggaag atgaaggcgg    180

ctgtcaagca ctctgggaag ggtgccctgg tcacaggggc catggccttc gtcgggggtt    240

tggtgggcgg cccaccggga ctcgccgttg ggggggctgt cggggggctg ttaggtgcct    300

ggatgacaag tggacagttt aagccggttc ctcagatcct aatggagctg ccccctgccg    360

agcaacagag gctctttaac gaagccgcag ccatcatcag gccctgcagc agcagctgct    420

ggccatgctg gtgaactacg tcaccaagga gctgcgggcc gagatccagt atgatgacta    480

ggccgcacct ccggggaggt ggggggcccc tttaaatgac tctgtgattc tgaagaggtg    540

gcttgggagt tgggagaagc ccagcggatg ccccctgggg aatctccaca tcatcagtgt    600

attactagta atgtcccgct ggagaggcca ccgctgtgca gtgtcatgtt ccagaaatta    660

ctgatgaagc agcatgtgtt ggtggcatgt gcactggcct gccatgacag ccctctgact    720

ggccccccag tgaagagtaa aggcctgcct gccgcaggct tcggaggcgt ctgctgagtc    780

ctctcacccg catgggtctg gggaagtgat cacgctcagc cgacggtctg accacacttc    840

atcctccccc cggggccttc tcatcttggg agatgactcc tcttcagagc acctgctgca    900

ggactggatc ccacccccct gcaggtcctg gggtctcagg gccttggagc agcccatgct    960

ggaatcatgt ttacctccta gtgcaaccgt cccctaccca gggactgtcg aatggcccca   1020

cggaggggac gggcggcctg ctgagtgaag ccacaaatac cgagtggact tgaccccggc   1080

ccccactagg ctgcacacct agactcgccc tgccagggcc tcgctcttcc catctgaaaa   1140

gtcctggtag ttcttgaggt ttacttctca aatgaaatat ttttagtaaa aagtacaggt   1200

atatctcgga gatattgtgg gttcagttcc agaccacctc ggtaaagcca acatcacaat   1260

aaagcaagga agcgcattgt tttagtttcc cagtgcatct aagtcatgtt tactgcatat   1320

tgcagtccac taaatgtgca atagcattat gtctaacaaa tatacaaacc ttaatttaaa   1380

aatatttact gttcaaaatg ctgacacaga aacgcaaagt gagcacatgc tgttggaaaa   1440

tggtgccaaa tagacttgcc tgatgccagg ctgctacaaa ccttcaattt aaaaaaaaaa   1500

aaaaaa                                                              1506


<210>  1008
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  1008

Met Thr Ile Met Val Glu Asp Ile Met Lys Leu Leu Cys Ser Leu Ser 
1               5                   10                  15      


Gly Glu Arg Lys Met Lys Ala Ala Val Lys His Ser Gly Lys Gly Ala 
            20                  25                  30          


Leu Val Thr Gly Ala Met Ala Phe Val Gly Gly Leu Val Gly Gly Pro 
        35                  40                  45              


Pro Gly Leu Ala Val Gly Gly Ala Val Gly Gly Leu Leu Gly Ala Trp 
    50                  55                  60                  


Met Thr Ser Gly Gln Phe Lys Pro Val Pro Gln Ile Leu Met Glu Leu 
65                  70                  75                  80  


Pro Pro Ala Glu Gln Gln Arg Leu Phe Asn Glu Ala Ala Ala Ile Ile 
                85                  90                  95      


Arg Pro Cys Ser Ser Ser Cys Trp Pro Cys Trp 
            100                 105         


<210>  1009
<211>  1916
<212>  DNA
<213>  Homosapiens

<400>  1009
cggggagccc ggggcctgcc aggcccgggc tgcagccgcg tctgatcgcc gagcgcgccg     60

cgtagacctc cgctccccca gggggggctg tcggggggct gttaggtgcc tggatgacaa    120

gtggacagtt taagccggtt cctcagatcc taatggagct gccccctgcc gagcaacaga    180

ggctctttaa cgaagccgca gccatcatca ggcacctgga gtggacggac gccgtgcagc    240

tgaccgcgct ggtcatgggc agcgaggccc tgcagcagca gctgctggcc atgctggtga    300

actacgtcac caaggagctg cgggccgaga tccagtatga tgactaggcc gcacctccgg    360

ggaggtgggg ggccccttta aatgactctg tgattctgaa gaggtggctt gggagttggg    420

agaagcccag cggatgcccc ctggggaatc tccacatcat cagtgtatta ctagtaatgt    480

cccgctggag aggccaccgc tgtgcagtgt catgttccag aaattactga tgaagcagca    540

tgtgttggtg gcatgtgcac tggcctgcca tgacagccct ctgactggcc ccccagtgaa    600

gagtaaaggc ctgcctgccg caggcttcgg aggcgtctgc tgagtcctct cacccgcatg    660

ggtctgggga agtgatcacg ctcagccgac ggtctgacca cacttcatcc tccccccggg    720

gccttctcat cttgggagat gactcctctt cagagcacct gctgcaggac tggatcccac    780

ccccctgcag gtcctggggt ctcagggcct tggagcagcc catgctggaa tcatgtttac    840

ctcctagtgc aaccgtcccc tacccaggga ctgtcgaatg gccccacgga ggggacgggc    900

ggcctgctga gtgaagccac aaataccgag tggacttgac cccggccccc actaggctgc    960

acacctagac tcgccctgcc agggcctcgc tcttcccatc tgaaaagtcc tggtagttct   1020

tgaggtttac ttctcaaatg aaatattttt agtaaaaagt acaggtatat ctcggagata   1080

ttgtgggttc agttccagac cacctcggta aagccaacat cacaataaag caaggaagcg   1140

cattgtttta gtttcccagt gcatctaagt catgtttact gcatattgca gtccactaaa   1200

tgtgcaatag cattatgtct aacaaatgta caaaccttaa tttaaaaata tttactgttc   1260

aaaatgctga cacagaaacg caaagtgagc acatgctgtt ggaaaatggt gccaaataga   1320

cttgcctgat gccaggctgc tacaaacctt caatttaaaa aaaaaacaca gtattcacaa   1380

agcatagtag aatgaggtat gcctgtattg ctctttctga agtggtgtga tataaaccat   1440

ctctaagaaa tgtttctacc ctaaagattt ccccagtaca gtcagctctc cgtaactgtg   1500

gtctccacat ttagatccaa ccagccttgg ataggaaata tttgaaaaaa gaaattgcat   1560

tggtactgaa cacgtacaga cctttttttc ttgccattat tccctaaaca atatggtgta   1620

gcatatttac atagcattta tattgtattt ggtattataa gaaatctaga gatgatttaa   1680

attatacagg aaggtgtgcg taggttacgt gcaaacgcta tgccattgcc catcagggac   1740

ttgagcatcc tcagatgtcg gtgtctgagg gttgaggttg cagtcctgga acccatcccc   1800

catggatact gaggcatagc tgtactgtgt gttttcactt tgctttcaga actacgactt   1860

gaatgtgatc gattacaata aatgtttttc taaaaaaaaa aaaaaaaaaa aaaaaa       1916


<210>  1010
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  1010

Met Thr Ser Gly Gln Phe Lys Pro Val Pro Gln Ile Leu Met Glu Leu 
1               5                   10                  15      


Pro Pro Ala Glu Gln Gln Arg Leu Phe Asn Glu Ala Ala Ala Ile Ile 
            20                  25                  30          


Arg His Leu Glu Trp Thr Asp Ala Val Gln Leu Thr Ala Leu Val Met 
        35                  40                  45              


Gly Ser Glu Ala Leu Gln Gln Gln Leu Leu Ala Met Leu Val Asn Tyr 
    50                  55                  60                  


Val Thr Lys Glu Leu Arg Ala Glu Ile Gln Tyr Asp Asp 
65                  70                  75          


<210>  1011
<211>  3785
<212>  DNA
<213>  Homosapiens

<400>  1011
gcggcggcgg cggcggcggc ggcagcggcg gccaagcggc caggttggcg gccggggctc     60

cgggccgcgc gaggccacgg ccacgccgcg ccgctgcgca caaccaacga ggcagagcgc    120

cgcccggcgc gagactgcgg ccgaagcgtg gggcgcgcgt gcggaggacc aggcgcggcg    180

cggctgcggc tgagagtgga gcctttcagg ctggcatgga gagcttaagg ggcaactgaa    240

ggagacacac tggccaagcg cggagttctg cttacttcag tcctgctgag atactctctc    300

agtccgctcg caccgaagga agctgccttg ggatcagagc agacataaag ctagaaaaat    360

ttcaagacag aaacagtctc cgccagtcaa gaaaccctca aaagtatttt gccatggata    420

tagaagatga agaaaacatg agttccagca gcactgatgt gaaggaaaac cgcaatctgg    480

acaacgtgtc ccccaaggat ggcagcacac ctgggcctgg cgagggctct cagctctcca    540

atgggggtgg tggtggcccc ggcagaaagc ggcccctgga ggagggcagc aatggccact    600

ccaagtaccg cctgaagaaa aggaggaaaa caccagggcc cgtcctcccc aagaacgccc    660

tgatgcagct gaatgagatc aagcctggtt tgcagtacac actcctgtcc cagactgggc    720

ccgtgcacgc gcctttgttt gtcatgtctg tggaggtgaa tggccaggtt tttgagggct    780

ctggtcccac aaagaaaaag gcaaaactcc atgctgctga gaaggccttg aggtctttcg    840

ttcagtttcc taatgcctct gaggcccacc tggccatggg gaggaccctg tctgtcaaca    900

cggacttcac atctgaccag gccgacttcc ctgacacgct cttcaatggt tttgaaactc    960

ctgacaaggc ggagcctccc ttttacgtgg gctccaatgg ggatgactcc ttcagttcca   1020

gcggggacct cagcttgtct gcttccccgg tgcctgccag cctagcccag cctcctctcc   1080

ctgtcttacc accattccca cccccgagtg ggaagaatcc cgtgatgatc ttgaacgaac   1140

tgcgcccagg actcaagtat gacttcctct ccgagagcgg ggagagccat gccaagagct   1200

tcgtcatgtc tgtggtcgtg gatggtcagt tctttgaagg ctcggggaga aacaagaagc   1260

ttgccaaggc ccgggctgcg cagtctgccc tggccgccat ttttaacttg cacttggatc   1320

agacgccatc tcgccagcct attcccagtg agggtcttca gctgcattta ccgcaggttt   1380

tagctgacgc tgtctcacgc ctggtcctgg gtaagtttgg tgacctgacc gacaacttct   1440

cctcccctca cgctcgcaga aaagtgctgg ctggagtcgt catgacaaca ggcacagatg   1500

ttaaagatgc caaggtgata agtgtttcta caggaacaaa atgtattaat ggtgaataca   1560

tgagtgatcg tggccttgca ttaaatgact gccatgcaga aataatatct cggagatcct   1620

tgctcagatt tctttataca caacttgagc tttacttaaa taacaaagat gatcaaaaaa   1680

gatccatctt tcagaaatca gagcgagggg ggtttaggct gaaggagaat gtccagtttc   1740

atctgtacat cagcacctct ccctgtggag atgccagaat cttctcacca catgagccaa   1800

tcctggaaga accagcagat agacacccaa atcgtaaagc aagaggacag ctacggacca   1860

aaatagagtc tggtgagggg acgattccag tgcgctccaa tgcgagcatc caaacgtggg   1920

acggggtgct gcaaggggag cggctgctca ccatgtcctg cagtgacaag attgcacgct   1980

ggaacgtggt gggcatccag ggatccctgc tcagcatttt cgtggagccc atttacttct   2040

cgagcatcat cctgggcagc ctttaccacg gggaccacct ttccagggcc atgtaccagc   2100

ggatctccaa catagaggac ctgccacctc tctacaccct caacaagcct ttgctcagtg   2160

gcatcagcaa tgcagaagca cggcagccag ggaaggcccc caacttcagt gtcaactgga   2220

cggtaggcga ctccgctatt gaggtcatca acgccacgac tgggaaggat gagctgggcc   2280

gcgcgtcccg cctgtgtaag cacgcgttgt actgtcgctg gatgcgtgtg cacggcaagg   2340

ttccctccca cttactacgc tccaagatta ccaagcccaa cgtgtaccat gagtccaagc   2400

tggcggcaaa ggagtaccag gccgccaagg cgcgtctgtt cacagccttc atcaaggcgg   2460

ggctgggggc ctgggtggag aagcccaccg agcaggacca gttctcactc acgccctgac   2520

ccgggcagac atgatggggg gtgcaggggg ctgtgggcat ccagcgtcat cctccagaac   2580

ctcacatctg aactgggggc aggtgcatac cttggggagg gagtaggggg acacggggga   2640

ccaccaggtg tccacggttg tccccagcat ctcacatcag acctggggca ggtgcgcagt   2700

gtggggaggg gatggggtgc gtcagggccc agcatcgccg cctggcatct ctctgccgca   2760

gcatttcccc ttctgaaccg tccagtgact gctttcaatc tcggtttacg tttagaaatt   2820

gagttctact gagtagggct tccttaagtt taggaaaata gaaattactt tgtgtgaaat   2880

tcttgaataa ataatttatt cagagctagg aatgtggttt ataaaatagg aagtaattgt   2940

gtcaggtcac ttttatgcca cattatttta attgcaaaaa agcatctata tatggaggag   3000

ggtgggaaaa tagaggtagg aaatagtagc ctaaaggaaa tcgccacacg tctgtctaaa   3060

cttaggtctc ttttctccgt aggtacctcc ctgggtagtt ccacacacta ggttgtaaca   3120

gtctctccct gaggagcaga ctcccagcat ggtgtagcgt ggccctgtca tgcacatggg   3180

gtcccgcagc agtgactgtg tgtcctgcag aggcgtgacc caggcccctg tagccctcag   3240

cctcctctag aagcttctgt actccttgta ggatcagatc atggaaaact tttctcagtt   3300

tacttctaag taatcacaga taatacatgg ccagtaatcc caggctggcc attcattcag   3360

gttttttaaa ggatatttaa cttttatgga ctagaaggaa tcacgagggc tactgcacaa   3420

tacatggcct aagttccctc tgttccttcc tctgaatcga atggatgtgg gtgaccgccc   3480

gaaggccttc acaggatgga agtagaatga tttcagtaga tactcattct tggaaaatgc   3540

catagtttta aattattgtt tccagcttta tcaaagacat gtttgaaaaa taaaaagcat   3600

ccaagtgaga gctggtgaga ccacgtgctg ctggcgtagt gtaggccaga cattgacagt   3660

cctgacggga gctcagggct gcccagcgcc cagcgtgcac gggacggccc cacgacagag   3720

ggagtcagcc cgggaggtca ggagcgcggc gggcgagggc cctgtgtgga ccacctccac   3780

caagc                                                               3785


<210>  1012
<211>  701
<212>  PRT
<213>  Homosapiens

<400>  1012

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu 
465                 470                 475                 480 


Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn 
                485                 490                 495     


Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu 
            500                 505                 510         


Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile 
        515                 520                 525             


Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser 
    530                 535                 540                 


Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met 
545                 550                 555                 560 


Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu 
                565                 570                 575     


Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro 
            580                 585                 590         


Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala 
        595                 600                 605             


Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala 
    610                 615                 620                 


Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His 
625                 630                 635                 640 


Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn 
                645                 650                 655     


Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys 
            660                 665                 670         


Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val 
        675                 680                 685             


Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro 
    690                 695                 700     


<210>  1013
<211>  5035
<212>  DNA
<213>  Homosapiens

<400>  1013
gcggcggcgg cggcggcggc ggcagcggcg gccaagcggc caggttggcg gccggggctc     60

cgggccgcgc gaggccacgg ccacgccgcg ccgctgcgca caaccaacga ggcagagcgc    120

cgcccggcgc gagactgcgg ccgaagcgtg gggcgcgcgt gcggaggacc aggcgcggcg    180

cggctgcggc tgagagtgga gcctttcagg ctggcatgga gagcttaagg ggcaactgaa    240

ggagacacac tggccaagcg cggagttctg cttacttcag tcctgctgag atactctctc    300

agtccgctcg caccgaagga agctgccttg ggatcagagc agacataaag ctagaaaaat    360

ttcaagacag aaacagtctc cgccagtcaa gaaaccctca aaagtatttt gccatggata    420

tagaagatga agaaaacatg agttccagca gcactgatgt gaaggaaaac cgcaatctgg    480

acaacgtgtc ccccaaggat ggcagcacac ctgggcctgg cgagggctct cagctctcca    540

atgggggtgg tggtggcccc ggcagaaagc ggcccctgga ggagggcagc aatggccact    600

ccaagtaccg cctgaagaaa aggaggaaaa caccagggcc cgtcctcccc aagaacgccc    660

tgatgcagct gaatgagatc aagcctggtt tgcagtacac actcctgtcc cagactgggc    720

ccgtgcacgc gcctttgttt gtcatgtctg tggaggtgaa tggccaggtt tttgagggct    780

ctggtcccac aaagaaaaag gcaaaactcc atgctgctga gaaggccttg aggtctttcg    840

ttcagtttcc taatgcctct gaggcccacc tggccatggg gaggaccctg tctgtcaaca    900

cggacttcac atctgaccag gccgacttcc ctgacacgct cttcaatggt tttgaaactc    960

ctgacaaggc ggagcctccc ttttacgtgg gctccaatgg ggatgactcc ttcagttcca   1020

gcggggacct cagcttgtct gcttccccgg tgcctgccag cctagcccag cctcctctcc   1080

ctgtcttacc accattccca cccccgagtg ggaagaatcc cgtgatgatc ttgaacgaac   1140

tgcgcccagg actcaagtat gacttcctct ccgagagcgg ggagagccat gccaagagct   1200

tcgtcatgtc tgtggtcgtg gatggtcagt tctttgaagg ctcggggaga aacaagaagc   1260

ttgccaaggc ccgggctgcg cagtctgccc tggccgccat ttttaacttg cacttggatc   1320

agacgccatc tcgccagcct attcccagtg agggtcttca gctgcattta ccgcaggttt   1380

tagctgacgc tgtctcacgc ctggtcctgg gtaagtttgg tgacctgacc gacaacttct   1440

cctcccctca cgctcgcaga aaagtgctgg ctggagtcgt catgacaaca ggcacagatg   1500

ttaaagatgc caaggtgata agtgtttcta caggaacaaa atgtattaat ggtgaataca   1560

tgagtgatcg tggccttgca ttaaatgact gccatgcaga aataatatct cggagatcct   1620

tgctcagatt tctttataca caacttgagc tttacttaaa taacaaagat gatcaaaaaa   1680

gatccatctt tcagaaatca gagcgagggg ggtttaggct gaaggagaat gtccagtttc   1740

atctgtacat cagcacctct ccctgtggag atgccagaat cttctcacca catgagccaa   1800

tcctggaagg gtctcgctct tacacccagg ctggagtgca gtggtgcaat catggctcac   1860

tgcagcctcg acctcctggg ctcttaagcg atccttccac ctcaaccttc caaggagctg   1920

ggactacaga accagcagat agacacccaa atcgtaaagc aagaggacag ctacggacca   1980

aaatagagtc tggtgagggg acgattccag tgcgctccaa tgcgagcatc caaacgtggg   2040

acggggtgct gcaaggggag cggctgctca ccatgtcctg cagtgacaag attgcacgct   2100

ggaacgtggt gggcatccag ggatccctgc tcagcatttt cgtggagccc atttacttct   2160

cgagcatcat cctgggcagc ctttaccacg gggaccacct ttccagggcc atgtaccagc   2220

ggatctccaa catagaggac ctgccacctc tctacaccct caacaagcct ttgctcagtg   2280

gcatcagcaa tgcagaagca cggcagccag ggaaggcccc caacttcagt gtcaactgga   2340

cggtaggcga ctccgctatt gaggtcatca acgccacgac tgggaaggat gagctgggcc   2400

gcgcgtcccg cctgtgtaag cacgcgttgt actgtcgctg gatgcgtgtg cacggcaagg   2460

ttccctccca cttactacgc tccaagatta ccaagcccaa cgtgtaccat gagtccaagc   2520

tggcggcaaa ggagtaccag gccgccaagg cgcgtctgtt cacagccttc atcaaggcgg   2580

ggctgggggc ctgggtggag aagcccaccg agcaggacca gttctcactc acgccctgac   2640

ccgggcagac atgatggggg gtgcaggggg ctgtgggcat ccagcgtcat cctccagaac   2700

ctcacatctg aactgggggc aggtgcatac cttggggagg gagtaggggg acacggggga   2760

ccaccaggtg tccacggttg tccccagcat ctcacatcag acctggggca ggtgcgcagt   2820

gtggggaggg gatggggtgc gtcagggccc agcatcgccg cctggcatct ctctgccgca   2880

gcatttcccc ttctgaaccg tccagtgact gctttcaatc tcggtttacg tttagaaatt   2940

gagttctact gagtagggct tccttaagtt taggaaaata gaaattactt tgtgtgaaat   3000

tcttgaataa ataatttatt cagagctagg aatgtggttt ataaaatagg aagtaattgt   3060

gtcaggtcac ttttatgcca cattatttta attgcaaaaa agcatctata tatggaggag   3120

ggtgggaaaa tagaggtagg aaatagtagc ctaaaggaaa tcgccacacg tctgtctaaa   3180

cttaggtctc ttttctccgt aggtacctcc ctgggtagtt ccacacacta ggttgtaaca   3240

gtctctccct gaggagcaga ctcccagcat ggtgtagcgt ggccctgtca tgcacatggg   3300

gtcccgcagc agtgactgtg tgtcctgcag aggcgtgacc caggcccctg tagccctcag   3360

cctcctctag aagcttctgt actccttgta ggatcagatc atggaaaact tttctcagtt   3420

tacttctaag taatcacaga taatacatgg ccagtaatcc caggctggcc attcattcag   3480

gttttttaaa ggatatttaa cttttatgga ctagaaggaa tcacgagggc tactgcacaa   3540

tacatggcct aagttccctc tgttccttcc tctgaatcga atggatgtgg gtgaccgccc   3600

gaaggccttc acaggatgga agtagaatga tttcagtaga tactcattct tggaaaatgc   3660

catagtttta aattattgtt tccagcttta tcaaagacat gtttgaaaaa taaaaagcat   3720

ccaagtgaga gctggtgaga ccacgtgctg ctggcgtagt gtaggccaga cattgacagt   3780

cctgacggga gctcagggct gcccagcgcc cagcgtgcac gggacggccc cacgacagag   3840

ggagtcagcc cgggaggtca ggagcgcggc gggcgagggc cctgtgtgga ccacctccac   3900

caagctcaga gatttgcaac caggtgcctt gttgcctccg ctcaggatga aagaggagct   3960

gagagaagtg ctctgcctgc cagtgcagtg cccagctcca aggctctaga gggtgttcag   4020

gtacactgag gaggggacgg ctccgtcttc acattgtgca cagatctgag gatgggatta   4080

gcgaagctgt ggagactgca catccggacc tgcccatgtc tcaaaacaaa cacatgtaca   4140

gtggctcttt ttccttctca aacactttac cccagaagca ggtggtctgc cccaggcata   4200

aagaaggaaa attggccatc tttcccacct ctaaattctg taaaattata gacttgctca   4260

aaagattcct ttttatcatc cccacgctgt gtaagtggaa agggcattgt gttccgtgtg   4320

tgtccagttt acagcgtctc tgccccctag cgtgttttgt gacaatctcc cctgggtgag   4380

gagtgggtgc acccagcccc gaggccagtg gttgctcggg gccttccgtg tgagttctag   4440

tgttcacttg atgccgggga atagaattag agaaaactct gacctgccgg gttccaggga   4500

ctggtggagg tggatggcag gtccgactcg accatgactt agttgtaagg gtgtgtcggc   4560

tttttcagtc tcatgtgaaa atcctcctgt ctctggcagc actgtctgca ctttcttgtt   4620

tactgtttga agggacgagt accaagccac aaggaacact tcttttggcc acagcataag   4680

ctgatggtat gtaaggaacc gatgggccat taaacatgaa ctgaacggtt aaaagcacag   4740

tctatggaac gctaatggag tcagccccta aagctgtttg ctttttcagg ctttggatta   4800

catgctttta atttgatttt agaatctgga cactttctat gaatgtaatt cggctgagaa   4860

acatgttgct gagatgcaat cctcagtgtt ctctgtatgt aaatctgtgt atacaccaca   4920

cgttacaact gcatgagctt cctctcgcac aagaccagct ggaactgagc atgagacgct   4980

gtcaaataca gacaaaggat ttgagatgtt ctcaataaaa agaaaatgtt tcact        5035


<210>  1014
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  1014

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
465                 470                 475                 480 


Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
                485                 490                 495     


Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
            500                 505                 510         


Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu 
        515                 520                 525             


Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
    530                 535                 540                 


Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
545                 550                 555                 560 


Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
                565                 570                 575     


Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
            580                 585                 590         


Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
        595                 600                 605             


Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
    610                 615                 620                 


Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
625                 630                 635                 640 


Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
                645                 650                 655     


Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
            660                 665                 670         


Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
        675                 680                 685             


Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
    690                 695                 700                 


Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile 
705                 710                 715                 720 


Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln 
                725                 730                 735     


Phe Ser Leu Thr Pro 
            740     


<210>  1015
<211>  3564
<212>  DNA
<213>  Homosapiens

<400>  1015
gcggcggcgg cggcggcggc ggcagcggcg gccaagcggc caggttggcg gccggggctc     60

cgggccgcgc gaggccacgg ccacgccgcg ccgctgcgca caaccaacga ggcagagcgc    120

cgcccggcgc gagactgcgg ccgaagcgtg gggcgcgcgt gcggaggacc aggcgcggcg    180

cggctgcggc tgagagtgga gcctttcagg ctggcatgga gagcttaagg ggcaactgaa    240

ggagacacac tggccaagcg cggagttctg cttacttcag tcctgctgag atactctctc    300

agtccgctcg caccgaagga agctgccttg ggatcagagc agacataaag ctagaaaaat    360

ttcaagacag aaacagtctc cgccagtcaa gaaaccctca aaagtatttt gccatggata    420

tagaagatga agaaaacatg agttccagca gcactgatgt gaaggaaaac cgcaatctgg    480

acaacgtgtc ccccaaggat ggcagcacac ctgggcctgg cgagggctct cagctctcca    540

atgggggtgg tggtggcccc ggcagaaagc ggcccctgga ggagggcagc aatggccact    600

ccaagtaccg cctgaagaaa aggaggaaaa caccagggcc cgtcctcccc aagaacgccc    660

tgatgcagct gaatgagatc aagcctggtt tgcagtacac actcctgtcc cagactgggc    720

ccgtgcacgc gcctttgttt gtcatgtctg tggaggtgaa tggccaggtt tttgagggct    780

ctggtcccac aaagaaaaag gcaaaactcc atgctgctga gaaggccttg aggtctttcg    840

ttcagtttcc taatgcctct gaggcccacc tggccatggg gaggaccctg tctgtcaaca    900

cggacttcac atctgaccag gccgacttcc ctgacacgct cttcaatggt tttgaaactc    960

ctgacaaggc ggagcctccc ttttacgtgg gctccaatgg ggatgactcc ttcagttcca   1020

gcggggacct cagcttgtct gcttccccgg tgcctgccag cctagcccag cctcctctcc   1080

ctgtcttacc accattccca cccccgagtg ggaagaatcc cgtgatgatc ttgaacgaac   1140

tgcgcccagg actcaagtat gacttcctct ccgagagcgg ggagagccat gccaagagct   1200

tcgtcatgtc tgtggtcgtg gatggtcagt tctttgaagg ctcggggaga aacaagaagc   1260

ttgccaaggc ccgggctgcg cagtctgccc tggccgccat ttttaacttg cacttggatc   1320

agacgccatc tcgccagcct attcccagtg agggtcttca gctgcattta ccgcaggttt   1380

tagctgacgc tgtctcacgc ctggtcctgg gtaagtttgg tgacctgacc gacaacttct   1440

cctcccctca cgctcgcaga aaagtgctgg ctggagtcgt catgacaaca ggcacagatg   1500

ttaaagatgc caaggtgata agtgtttcta caggaacaaa atgtattaat ggtgaataca   1560

tgagtgatcg tggccttgca ttaaatgact gccatgcaga aataatatct cggagatcct   1620

tgctcagatt tctttataca caacttgagc tttacttaaa taacaaagat gatcaaaaaa   1680

gatccatctt tcagaaatca gagcgagggg ggtttaggct gaaggagaat gtccagtttc   1740

atctgtacat cagcacctct ccctgtggag atgccagaat cttctcacca catgagccaa   1800

tcctggaagg gtctcgctct tacacccagg ctggagtgca gtggtgcaat catggctcac   1860

tgcagcctcg acctcctggg ctcttaagcg atccttccac ctcaaccttc caaggagctg   1920

ggactacaga accagcagat agacacccaa atcgtaaagc aagaggacag ctacggacca   1980

aaatagagtc tggtgagggg acgattccag tgcgctccaa tgcgagcatc caaacgtggg   2040

acggggtgct gcaaggggag cggctgctca ccatgtcctg cagtgacaag attgcacgct   2100

ggaacgtggt gggcatccag ggatccctgc tcagcatttt cgtggagccc atttacttct   2160

cgagcatcat cctgggcagc ctttaccacg gggaccacct ttccagggcc atgtaccagc   2220

ggatctccaa catagaggac ctgccacctc tctacaccct caacaagcct ttgctcagtg   2280

gcatcagcaa tgcagaagca cggcagccag ggaaggcccc caacttcagt gtcaactgga   2340

cggtaggcga ctccgctatt gaggtcatca acgccacgac tgggaaggat gagctgggcc   2400

gcgcgtcccg cctgtgtaag cacgcgttgt actgtcgctg gatgcgtgtg cacggcaagg   2460

ttccctccca cttactacgc tccaagatta ccaagcccaa cgtgtaccat gagtccaagc   2520

tggcggcaaa ggagtaccag gccgccaagg tacactgagg aggggacggc tccgtcttca   2580

cattgtgcac agatctgagg atgggattag cgaagctgtg gagactgcac atccggacct   2640

gcccatgtct caaaacaaac acatgtacag tggctctttt tccttctcaa acactttacc   2700

ccagaagcag gtggtctgcc ccaggcataa agaaggaaaa ttggccatct ttcccacctc   2760

taaattctgt aaaattatag acttgctcaa aagattcctt tttatcatcc ccacgctgtg   2820

taagtggaaa gggcattgtg ttccgtgtgt gtccagttta cagcgtctct gccccctagc   2880

gtgttttgtg acaatctccc ctgggtgagg agtgggtgca cccagccccg aggccagtgg   2940

ttgctcgggg ccttccgtgt gagttctagt gttcacttga tgccggggaa tagaattaga   3000

gaaaactctg acctgccggg ttccagggac tggtggaggt ggatggcagg tccgactcga   3060

ccatgactta gttgtaaggg tgtgtcggct ttttcagtct catgtgaaaa tcctcctgtc   3120

tctggcagca ctgtctgcac tttcttgttt actgtttgaa gggacgagta ccaagccaca   3180

aggaacactt cttttggcca cagcataagc tgatggtatg taaggaaccg atgggccatt   3240

aaacatgaac tgaacggtta aaagcacagt ctatggaacg ctaatggagt cagcccctaa   3300

agctgtttgc tttttcaggc tttggattac atgcttttaa tttgatttta gaatctggac   3360

actttctatg aatgtaattc ggctgagaaa catgttgctg agatgcaatc ctcagtgttc   3420

tctgtatgta aatctgtgta tacaccacac gttacaactg catgagcttc ctctcgcaca   3480

agaccagctg gaactgagca tgagacgctg tcaaatacag acaaaggatt tgagatgttc   3540

tcaataaaaa gaaaatgttt cact                                          3564


<210>  1016
<211>  714
<212>  PRT
<213>  Homosapiens

<400>  1016

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
465                 470                 475                 480 


Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
                485                 490                 495     


Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
            500                 505                 510         


Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu 
        515                 520                 525             


Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
    530                 535                 540                 


Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
545                 550                 555                 560 


Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
                565                 570                 575     


Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
            580                 585                 590         


Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
        595                 600                 605             


Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
    610                 615                 620                 


Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
625                 630                 635                 640 


Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
                645                 650                 655     


Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
            660                 665                 670         


Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
        675                 680                 685             


Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
    690                 695                 700                 


Ala Lys Glu Tyr Gln Ala Ala Lys Val His 
705                 710                 


<210>  1017
<211>  2874
<212>  DNA
<213>  Homosapiens

<400>  1017
agtgcgtggc cgcccggggc catggcgaca ctcagcttcg tcttcctgct gctgggggca     60

gtgtcctggc ctccggcttc tgcctccggc caggagttct ggcccggaca atcggcggcc    120

gatattctgt cgggggcggc ttcccgcaga cggtatcttc tgtatgacgt caaccccccg    180

gaaggcttca acctgcgcag ggatgtctat atccgaatcg cctctctcct gaagactctg    240

ctgaagacgg aggagtgggt gcttgtcctg cctccatggg gccgcctcta tcactggcag    300

agtcctgaca tccaccaggt ccggattccc tggtctgagt tttttgatct tccaagtctc    360

aataaaaaca tccccgtcat cgagtatgag cagttcatcg cagaatctgg tgggcccttt    420

attgaccagg tttacgtcct gcaaagttac gcagaggggt ggaaagaagg gacctgggaa    480

gagaaggtgg acgagcggcc gtgtattgat cagctcctgt actcccagga caagcacgag    540

tactacagag gatggttttg gggttatgag gagaccaggg gtctaaacgt ctcctgtctg    600

tccgtccagg gctcagcctc catcgtggcg cccctgctgc tgagaaacac atcagcccgg    660

tccgtgatgt tagacagagc cgagaaccta cttcacgacc actatggagg gaaagaatac    720

tgggataccc gtcgcagcat ggtgtttgcc aggcacctgc gggaggtggg agacgagttc    780

aggagcagac atctcaactc cacggacgac gcagacagga tccccttcca ggaggactgg    840

atgaagatga aggtcaagct gggctccgcg ctagggggcc cctacctggg agtccacctg    900

agaagaaaag atttcatctg gggtcacaga caggatgtac ccagtctgga aggggccgtg    960

aggaagatcc gcagcctcat gaagacccac cggctggaca aggtgtttgt ggccacagat   1020

gccgtcagaa aggaatatga agagctaaaa aagctgttac ccgagatggt gaggtttgaa   1080

cccacgtggg aggagctgga gctctacaag gacggaggcg ttgcgattat tgaccagtgg   1140

atctgcgcac acgccaggtt ttttattggc acctcagtct caacattttc ttttcggatt   1200

catgaggaaa gagaaatcct ggggttggac cccaagacga cgtacaacag gttctgcgga   1260

gaccaagaga aggcgtgtga gcaacccacc cactggaaga tcacctactg aggaggatcc   1320

tccagggccg ctccccggac ccgacaggcg cgggtggatg caggttctgt cgccgtggag   1380

tcaccgtcta ctgccagccg ggagctgggc ggacaggacc gtccctcgca gggtcccagg   1440

cccagaagag gccccacgcc tctagagctg ggctccgtcc tcggcgttgc cagccgccat   1500

ggctgatgaa gaggctccgc tgctctcggg ggtggcggtt gttttcaggc agcgtctgtg   1560

aacccacagc tcggttgcca gcagtgcccg cgtggtgacc cagaagcagg agtgtttgtc   1620

aggctcccgc tctggccttt ccagccacct ttcatgtctt catattttaa gtgcattgag   1680

gatagatgca ggcgggtgag ctgccctccg tcaggtggac ccgggctgac atttccctgg   1740

gagctggtgc aaggagaagc gtcattttaa atgtctgcag agcgaccagg ggcctcatga   1800

atctctccgt tgccctccgc gcagcaggag gctgcctgtg tgtttcctcc tgggatgcgt   1860

gcaaggcaga cctggtgctg caaaggaaag ggcctgaggc ctcagggagc cccgtggagg   1920

gatgacagtt caggccctac tgctggcacg tcagagcact gggaagtttt tcagtgacgt   1980

ctctggggca ctcagtggat tgtctgtagg aaacttgcag ctctgctcct cacaccaggc   2040

ccggctggcc acccaccctc gcccccactg gccacccctc cctcgccccg actgccccgc   2100

cccaccctca ccccgactgc cccgccctcg cccggctggc cgtccctgcc ctcgccccgg   2160

ctggcaggtg cacatggggc ctccaggtct gccattcgct attgagaact agaaatgagg   2220

aaggacagtt acgctaactc caaaaggctg tctaggatga gctgctttat cagggagctc   2280

cttgtaccca ttttacagaa atcattttta ggtctttgtg ccaccaccac gaggggcatc   2340

tgcaaagagg gcaacgctag acacagaatc cgtggaaggt gcagcagtgc ctcaggggtc   2400

ctcagggtca gggagccccc ctcaccctct tggcccgtta ccctttgtga ctttccacca   2460

tggtgtcgtg tgaccctcag tcaggttggt gggggctgag tcctcactga gcagccactt   2520

tccacatctg ctagaggaac agtgacatgg acacctgtga cagagagagg acagttagga   2580

gggacagaca gctcttcctt tcggagcctg gctagtctag gacatcacct tgctgtgtct   2640

tctcaagctt ttaaaattga ccctgaacgt gtgacagggt cctatggtgt tactcaaagc   2700

tgtgcagggt aaatgatgac atatttattc tttttccatt tgttctagaa acagtgcctt   2760

tttcatcagt tgcattttcc aggctgagag ctgtataaaa cattttggac tgtgaccatg   2820

taccttcctt tttaagaaaa ataaactgct ttatggaagt tggtaaaaaa aaaa         2874


<210>  1018
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  1018

Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly Ala Val Ser Trp 
1               5                   10                  15      


Pro Pro Ala Ser Ala Ser Gly Gln Glu Phe Trp Pro Gly Gln Ser Ala 
            20                  25                  30          


Ala Asp Ile Leu Ser Gly Ala Ala Ser Arg Arg Arg Tyr Leu Leu Tyr 
        35                  40                  45              


Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg Asp Val Tyr Ile 
    50                  55                  60                  


Arg Ile Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr Glu Glu Trp Val 
65                  70                  75                  80  


Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp Gln Ser Pro Asp 
                85                  90                  95      


Ile His Gln Val Arg Ile Pro Trp Ser Glu Phe Phe Asp Leu Pro Ser 
            100                 105                 110         


Leu Asn Lys Asn Ile Pro Val Ile Glu Tyr Glu Gln Phe Ile Ala Glu 
        115                 120                 125             


Ser Gly Gly Pro Phe Ile Asp Gln Val Tyr Val Leu Gln Ser Tyr Ala 
    130                 135                 140                 


Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val Asp Glu Arg Pro 
145                 150                 155                 160 


Cys Ile Asp Gln Leu Leu Tyr Ser Gln Asp Lys His Glu Tyr Tyr Arg 
                165                 170                 175     


Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu Asn Val Ser Cys 
            180                 185                 190         


Leu Ser Val Gln Gly Ser Ala Ser Ile Val Ala Pro Leu Leu Leu Arg 
        195                 200                 205             


Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala Glu Asn Leu Leu 
    210                 215                 220                 


His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr Arg Arg Ser Met 
225                 230                 235                 240 


Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu Phe Arg Ser Arg 
                245                 250                 255     


His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu Asp 
            260                 265                 270         


Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu Gly Gly Pro Tyr 
        275                 280                 285             


Leu Gly Val His Leu Arg Arg Lys Asp Phe Ile Trp Gly His Arg Gln 
    290                 295                 300                 


Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys Ile Arg Ser Leu Met 
305                 310                 315                 320 


Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr Asp Ala Val Arg 
                325                 330                 335     


Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu Met Val Arg Phe 
            340                 345                 350         


Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp Gly Gly Val Ala 
        355                 360                 365             


Ile Ile Asp Gln Trp Ile Cys Ala His Ala Arg Phe Phe Ile Gly Thr 
    370                 375                 380                 


Ser Val Ser Thr Phe Ser Phe Arg Ile His Glu Glu Arg Glu Ile Leu 
385                 390                 395                 400 


Gly Leu Asp Pro Lys Thr Thr Tyr Asn Arg Phe Cys Gly Asp Gln Glu 
                405                 410                 415     


Lys Ala Cys Glu Gln Pro Thr His Trp Lys Ile Thr Tyr 
            420                 425                 


<210>  1019
<211>  4828
<212>  DNA
<213>  Homosapiens

<400>  1019
agtgcgtggc cgcccggggc catggcgaca ctcagcttcg tcttcctgct gctgggggca     60

gtgtcctggc ctccggcttc tgcctccggc caggagttct ggcccggaca atcggcggcc    120

gatattctgt cgggggcggc ttcccgcaga cggtatcttc tgtatgacgt caaccccccg    180

gaaggcttca acctgcgcag ggatgtctat atccgaatcg cctctctcct gaagactctg    240

ctgaagacgg aggagtgggt gcttgtcctg cctccatggg gccgcctcta tcactggcag    300

agtcctgaca tccaccaggt ccggattccc tggtctgagt tttttgatct tccaagtctc    360

aataaaaaca tccccgtcat cgagtatgag cagttcatcg cagaatctgg tgggcccttt    420

attgaccagg tttacgtcct gcaaagttac gcagaggggt ggaaagaagg gacctgggaa    480

gagaaggtgg acgagcggcc gtgtattgat cagctcctgt actcccagga caagcacgag    540

tactacagag gatggttttg gggttatgag gagaccaggg gtctaaacgt ctcctgtctg    600

tccgtccagg gctcagcctc catcgtggcg cccctgctgc tgagaaacac atcagcccgg    660

tccgtgatgt tagacagagc cgagaaccta cttcacgacc actatggagg gaaagaatac    720

tgggataccc gtcgcagcat ggtgtttgcc aggcacctgc gggaggtggg agacgagttc    780

aggagcagac atctcaactc cacggacgac gcagacagga tccccttcca ggaggactgg    840

atgaagatga aggtcaagct gggctccgcg ctagggggcc cctacctggg agtccacctg    900

agaagaaaag atttcatctg gggtcacaga caggatgtac ccagtctgga aggggccgtg    960

aggaagatcc gcagcctcat gaagacccac cggctggaca aggtgtttgt ggccacagat   1020

gccgtcagaa aggaatatga agagctaaaa aagctgttac ccgagatggt gaggtttgaa   1080

cccacgtggg aggagctgga gctctacaag gacggaggcg ttgcgattat tgaccagtgg   1140

atctgcgcac acgccaggtg cctgcccacg tcactgtcgg ccgagagcgg gtcgggtggc   1200

tttcaaaggt tcttctgtcc caagtactcg gtgtcagagc agatggtcgc ctgtgttcac   1260

agtggtcatt tccatactgt ttgcctcctc gtctgagtct cctgtagcat ctggttcagt   1320

gtttccctgg gctgaagtta attgttcatc ttgccccttt agttctcatg cacagaattc   1380

ctccatagca ggctgttggc atagctggcc tcgtctcaga acctcttctt gtgtcgcatt   1440

ttcccatcat tcccggtttc tgcccctgtc tgccccctgc cctgagagtt gcccgtgccc   1500

tggacttggg catgtccttg ttgctgtgtt gttgagcatc cgtgagcgtc cccgaggccg   1560

ggagcgtggg ccctcgtgtg atcattctcg tggggctgcc atgagcgtcc ccaaggctgg   1620

gagcatgggc cctcgtgtga tcgttcttgt ggggctgccg tgagcgtccc cgaggccggg   1680

agcgtgggcc ctcgtgtgat cattctcgtg gggctgccgt gagcgtccca gaggccggga   1740

gcgtgggccc tgcgtgcagt cattcctctg gggttgctgt gggaggtacg cctgggcctc   1800

tgttcctcca aagacctgcc tgcccatctg cataggagat gaaggctggg gttagggtga   1860

aacggtttga gttaaatgga aaatgaaagt agagggaatg atcttccccg tggttagcac   1920

tgtgcacacg cgtgcgtctc tgtgggttag tctgtctctc tcctgcccga ggaatgctga   1980

gcgccctgag ccggtgcctc ttcacacatc tgctatttcc tgtggtgttc tgggcatggt   2040

gtgtaagacc cacagaggct ccgggtgatg ctgtctgctg ggtgtgggtc cctttccctg   2100

ttaagcagac aggatgcagc gctgacttct taggtcaggg cggaggtgtg caggagccca   2160

gtcacgagct cacccctgct tctcaggtgt ggccttggga ttttgactgc gaccttggcg   2220

gtgctgtctc cgcagcccag gaagcctgct gtggggaggc ttcgcactga gctctcagcc   2280

tcctgccctc agctgcgcga agcgctcggc ccagctcact gaagctgccc tgcctccggg   2340

ccggcgcggc ctgctctggc aggcccctgt gtgtggggtg gtgagggtct ccccaccagt   2400

gctgcacccc gcagcagcat acaggcctgt gtggcctgct ggccctgtgg ctctgtgtac   2460

agcgctgtgc atgttacatt tgctctggaa acatctctgg ggtttgcttg ttcacgaagt   2520

tcatgaagtg ccgctggaga gccagagacc agctgcgcag gagccggagg aacgggcagg   2580

ccgctgacct gaggtctgga gaaacccctg gagaagggtg tccccaccag cccatacagc   2640

gtgtgtgtgg agggggcctt gacctccgtg atgtctactg tgcctcagga taaggacccg   2700

ccatgccctg gctagacagt gtgtggttag taggaatctc tcattgttca ccatgtgacc   2760

cccaggaggt attcgacctg cactggcgtg cctggcctgg gatttggtga cggagaggag   2820

ggctcccagg gggacatgcg gtgggacagg agcgtggcgg ctgctgactg tggggtgtgg   2880

atggggctgc agcaccaggc agagcccctc agggcgccga tgtcgagggc acctgagcga   2940

ggggtgccag caagggggcg gccggctggt gggtgctcgg gggacggccg tgttggttcc   3000

atgtaactgt ggaactcatt tcactcagct gctcctctca gttctccctg actctggaac   3060

ctctgtgacc ccagttctcc ctgactctgg aacctctgtg atcctttgca ggttttttat   3120

tggcacctca gtctcaacat tttcttttcg gattcatgag gaaagagaaa tcctggggtt   3180

ggaccccaag acgacgtaca acaggttctg cggagaccaa gagaaggcgt gtgagcaacc   3240

cacccactgg aagatcacct actgaggagg atcctccagg gccgctcccc ggacccgaca   3300

ggcgcgggtg gatgcaggtt ctgtcgccgt ggagtcaccg tctactgcca gccgggagct   3360

gggcggacag gaccgtccct cgcagggtcc caggcccaga agaggcccca cgcctctaga   3420

gctgggctcc gtcctcggcg ttgccagccg ccatggctga tgaagaggct ccgctgctct   3480

cgggggtggc ggttgttttc aggcagcgtc tgtgaaccca cagctcggtt gccagcagtg   3540

cccgcgtggt gacccagaag caggagtgtt tgtcaggctc ccgctctggc ctttccagcc   3600

acctttcatg tcttcatatt ttaagtgcat tgaggataga tgcaggcggg tgagctgccc   3660

tccgtcaggt ggacccgggc tgacatttcc ctgggagctg gtgcaaggag aagcgtcatt   3720

ttaaatgtct gcagagcgac caggggcctc atgaatctct ccgttgccct ccgcgcagca   3780

ggaggctgcc tgtgtgtttc ctcctgggat gcgtgcaagg cagacctggt gctgcaaagg   3840

aaagggcctg aggcctcagg gagccccgtg gagggatgac agttcaggcc ctactgctgg   3900

cacgtcagag cactgggaag tttttcagtg acgtctctgg ggcactcagt ggattgtctg   3960

taggaaactt gcagctctgc tcctcacacc aggcccggct ggccacccac cctcgccccc   4020

actggccacc cctccctcgc cccgactgcc ccgccccacc ctcaccccga ctgccccgcc   4080

ctcgcccggc tggccgtccc tgccctcgcc ccggctggca ggtgcacatg gggcctccag   4140

gtctgccatt cgctattgag aactagaaat gaggaaggac agttacgcta actccaaaag   4200

gctgtctagg atgagctgct ttatcaggga gctccttgta cccattttac agaaatcatt   4260

tttaggtctt tgtgccacca ccacgagggg catctgcaaa gagggcaacg ctagacacag   4320

aatccgtgga aggtgcagca gtgcctcagg ggtcctcagg gtcagggagc ccccctcacc   4380

ctcttggccc gttacccttt gtgactttcc accatggtgt cgtgtgaccc tcagtcaggt   4440

tggtgggggc tgagtcctca ctgagcagcc actttccaca tctgctagag gaacagtgac   4500

atggacacct gtgacagaga gaggacagtt aggagggaca gacagctctt cctttcggag   4560

cctggctagt ctaggacatc accttgctgt gtcttctcaa gcttttaaaa ttgaccctga   4620

acgtgtgaca gggtcctatg gtgttactca aagctgtgca gggtaaatga tgacatattt   4680

attctttttc catttgttct agaaacagtg cctttttcat cagttgcatt ttccaggctg   4740

agagctgtat aaaacatttt ggactgtgac catgtacctt cctttttaag aaaaataaac   4800

tgctttatgg aagttggtaa aaaaaaaa                                      4828


<210>  1020
<211>  424
<212>  PRT
<213>  Homosapiens

<400>  1020

Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly Ala Val Ser Trp 
1               5                   10                  15      


Pro Pro Ala Ser Ala Ser Gly Gln Glu Phe Trp Pro Gly Gln Ser Ala 
            20                  25                  30          


Ala Asp Ile Leu Ser Gly Ala Ala Ser Arg Arg Arg Tyr Leu Leu Tyr 
        35                  40                  45              


Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg Asp Val Tyr Ile 
    50                  55                  60                  


Arg Ile Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr Glu Glu Trp Val 
65                  70                  75                  80  


Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp Gln Ser Pro Asp 
                85                  90                  95      


Ile His Gln Val Arg Ile Pro Trp Ser Glu Phe Phe Asp Leu Pro Ser 
            100                 105                 110         


Leu Asn Lys Asn Ile Pro Val Ile Glu Tyr Glu Gln Phe Ile Ala Glu 
        115                 120                 125             


Ser Gly Gly Pro Phe Ile Asp Gln Val Tyr Val Leu Gln Ser Tyr Ala 
    130                 135                 140                 


Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val Asp Glu Arg Pro 
145                 150                 155                 160 


Cys Ile Asp Gln Leu Leu Tyr Ser Gln Asp Lys His Glu Tyr Tyr Arg 
                165                 170                 175     


Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu Asn Val Ser Cys 
            180                 185                 190         


Leu Ser Val Gln Gly Ser Ala Ser Ile Val Ala Pro Leu Leu Leu Arg 
        195                 200                 205             


Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala Glu Asn Leu Leu 
    210                 215                 220                 


His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr Arg Arg Ser Met 
225                 230                 235                 240 


Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu Phe Arg Ser Arg 
                245                 250                 255     


His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu Asp 
            260                 265                 270         


Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu Gly Gly Pro Tyr 
        275                 280                 285             


Leu Gly Val His Leu Arg Arg Lys Asp Phe Ile Trp Gly His Arg Gln 
    290                 295                 300                 


Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys Ile Arg Ser Leu Met 
305                 310                 315                 320 


Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr Asp Ala Val Arg 
                325                 330                 335     


Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu Met Val Arg Phe 
            340                 345                 350         


Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp Gly Gly Val Ala 
        355                 360                 365             


Ile Ile Asp Gln Trp Ile Cys Ala His Ala Arg Cys Leu Pro Thr Ser 
    370                 375                 380                 


Leu Ser Ala Glu Ser Gly Ser Gly Gly Phe Gln Arg Phe Phe Cys Pro 
385                 390                 395                 400 


Lys Tyr Ser Val Ser Glu Gln Met Val Ala Cys Val His Ser Gly His 
                405                 410                 415     


Phe His Thr Val Cys Leu Leu Val 
            420                 


<210>  1021
<211>  3080
<212>  DNA
<213>  Homosapiens

<400>  1021
agtgcgtggc cgcccggggc catggcgaca ctcagcttcg tcttcctgct gctgggggca     60

gtgtcctggc ctccggcttc tgcctccggc caggagttct ggcccggaca atcggcggcc    120

gatattctgt cgggggcggc ttcccgcaga cggtatcttc tgtatgacgt caaccccccg    180

gaaggcttca acctgcgcag ggatgtctat atccgaatcg cctctctcct gaagactctg    240

ctgaagacgg aggagtgggt gcttgtcctg cctccatggg gccgcctcta tcactggcag    300

agtcctgaca tccaccaggt ccggattccc tggtctgagt tttttgatct tccaagtctc    360

aataaaaaca tccccgtcat cgagtatgag cagttcatcg cagaatctgg tgggcccttt    420

attgaccagg tttacgtcct gcaaagttac gcagaggggt ggaaagaagg gacctgggaa    480

gagaaggtgg acgagcggcc gtgtattgat cagctcctgt actcccagga caagcacgag    540

tactacagag gatggttttg gggttatgag gagaccaggg gtctaaacgt ctcctgtctg    600

tccgtccagg gctcagcctc catcgtggcg cccctgctgc tgagaaacac atcagcccgg    660

tccgtgatgt tagacagagc cgagaaccta cttcacgacc actatggagg gaaagaatac    720

tgggataccc gtcgcagcat ggtgtttgcc aggcacctgc gggaggtggg agacgagttc    780

aggagcagac atctcaactc cacggacgac gcagacagga tccccttcca ggaggactgg    840

atgaagatga aggtcaagct gggctccgcg ctagggggcc cctacctggg agtccacctg    900

agaagaaaag atttcatctg gggtcacaga caggatgtac ccagtctgga aggggccgtg    960

aggaagatcc gcagcctcat gaagacccac cggctggaca aggtgtttgt ggccacagat   1020

gccgtcagaa aggaatatga agagctaaaa aagctgttac ccgagatggt gaggtttgaa   1080

cccacgtggg aggagctgga gctctacaag gacggaggcg ttgcgattat tgaccagtgg   1140

atctgcgcac acgccagttc atgaagtgcc gctggagagc cagagaccag ctgcgcagga   1200

gccggaggaa cgggcaggcc gctgacctga ggtctggaga aacccctgga gaagggtgtc   1260

cccaccagcc catacagcgt gtgtgtggag ggggccttga cctccgtgat gtctactgtg   1320

cctcaggata aggacccgcc atgccctggc tagacagtgt gtggtttttt attggcacct   1380

cagtctcaac attttctttt cggattcatg aggaaagaga aatcctgggg ttggacccca   1440

agacgacgta caacaggttc tgcggagacc aagagaaggc gtgtgagcaa cccacccact   1500

ggaagatcac ctactgagga ggatcctcca gggccgctcc ccggacccga caggcgcggg   1560

tggatgcagg ttctgtcgcc gtggagtcac cgtctactgc cagccgggag ctgggcggac   1620

aggaccgtcc ctcgcagggt cccaggccca gaagaggccc cacgcctcta gagctgggct   1680

ccgtcctcgg cgttgccagc cgccatggct gatgaagagg ctccgctgct ctcgggggtg   1740

gcggttgttt tcaggcagcg tctgtgaacc cacagctcgg ttgccagcag tgcccgcgtg   1800

gtgacccaga agcaggagtg tttgtcaggc tcccgctctg gcctttccag ccacctttca   1860

tgtcttcata ttttaagtgc attgaggata gatgcaggcg ggtgagctgc cctccgtcag   1920

gtggacccgg gctgacattt ccctgggagc tggtgcaagg agaagcgtca ttttaaatgt   1980

ctgcagagcg accaggggcc tcatgaatct ctccgttgcc ctccgcgcag caggaggctg   2040

cctgtgtgtt tcctcctggg atgcgtgcaa ggcagacctg gtgctgcaaa ggaaagggcc   2100

tgaggcctca gggagccccg tggagggatg acagttcagg ccctactgct ggcacgtcag   2160

agcactggga agtttttcag tgacgtctct ggggcactca gtggattgtc tgtaggaaac   2220

ttgcagctct gctcctcaca ccaggcccgg ctggccaccc accctcgccc ccactggcca   2280

cccctccctc gccccgactg ccccgcccca ccctcacccc gactgccccg ccctcgcccg   2340

gctggccgtc cctgccctcg ccccggctgg caggtgcaca tggggcctcc aggtctgcca   2400

ttcgctattg agaactagaa atgaggaagg acagttacgc taactccaaa aggctgtcta   2460

ggatgagctg ctttatcagg gagctccttg tacccatttt acagaaatca tttttaggtc   2520

tttgtgccac caccacgagg ggcatctgca aagagggcaa cgctagacac agaatccgtg   2580

gaaggtgcag cagtgcctca ggggtcctca gggtcaggga gcccccctca ccctcttggc   2640

ccgttaccct ttgtgacttt ccaccatggt gtcgtgtgac cctcagtcag gttggtgggg   2700

gctgagtcct cactgagcag ccactttcca catctgctag aggaacagtg acatggacac   2760

ctgtgacaga gagaggacag ttaggaggga cagacagctc ttcctttcgg agcctggcta   2820

gtctaggaca tcaccttgct gtgtcttctc aagcttttaa aattgaccct gaacgtgtga   2880

cagggtccta tggtgttact caaagctgtg cagggtaaat gatgacatat ttattctttt   2940

tccatttgtt ctagaaacag tgcctttttc atcagttgca ttttccaggc tgagagctgt   3000

ataaaacatt ttggactgtg accatgtacc ttccttttta agaaaaataa actgctttat   3060

ggaagttggt aaaaaaaaaa                                               3080


<210>  1022
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  1022

Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly Ala Val Ser Trp 
1               5                   10                  15      


Pro Pro Ala Ser Ala Ser Gly Gln Glu Phe Trp Pro Gly Gln Ser Ala 
            20                  25                  30          


Ala Asp Ile Leu Ser Gly Ala Ala Ser Arg Arg Arg Tyr Leu Leu Tyr 
        35                  40                  45              


Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg Asp Val Tyr Ile 
    50                  55                  60                  


Arg Ile Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr Glu Glu Trp Val 
65                  70                  75                  80  


Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp Gln Ser Pro Asp 
                85                  90                  95      


Ile His Gln Val Arg Ile Pro Trp Ser Glu Phe Phe Asp Leu Pro Ser 
            100                 105                 110         


Leu Asn Lys Asn Ile Pro Val Ile Glu Tyr Glu Gln Phe Ile Ala Glu 
        115                 120                 125             


Ser Gly Gly Pro Phe Ile Asp Gln Val Tyr Val Leu Gln Ser Tyr Ala 
    130                 135                 140                 


Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val Asp Glu Arg Pro 
145                 150                 155                 160 


Cys Ile Asp Gln Leu Leu Tyr Ser Gln Asp Lys His Glu Tyr Tyr Arg 
                165                 170                 175     


Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu Asn Val Ser Cys 
            180                 185                 190         


Leu Ser Val Gln Gly Ser Ala Ser Ile Val Ala Pro Leu Leu Leu Arg 
        195                 200                 205             


Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala Glu Asn Leu Leu 
    210                 215                 220                 


His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr Arg Arg Ser Met 
225                 230                 235                 240 


Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu Phe Arg Ser Arg 
                245                 250                 255     


His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu Asp 
            260                 265                 270         


Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu Gly Gly Pro Tyr 
        275                 280                 285             


Leu Gly Val His Leu Arg Arg Lys Asp Phe Ile Trp Gly His Arg Gln 
    290                 295                 300                 


Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys Ile Arg Ser Leu Met 
305                 310                 315                 320 


Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr Asp Ala Val Arg 
                325                 330                 335     


Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu Met Val Arg Phe 
            340                 345                 350         


Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp Gly Gly Val Ala 
        355                 360                 365             


Ile Ile Asp Gln Trp Ile Cys Ala His Ala Ser Ser 
    370                 375                 380 


<210>  1023
<211>  1179
<212>  DNA
<213>  Homosapiens

<400>  1023
acatcaatca acagtgttta ctaaaacagc aatacagaat tacaacattt tatgggaaag     60

tgtcccattc attataacaa aaactttgtg gatttcataa aaatccacaa aatactcaag    120

aacaaaccaa gaaatgagca catcggacat caaagaaatc ttaaaaattt tgccaaagct    180

ctaaattcgt tgagagctgg aatccatttt caagtagtag gactctaagt cacatgaatg    240

tcaattttcc aaactgtccc cataaactcc gtgcatccct taaaactccc gcaggactgc    300

tgtgggtctt gacactgctt ctaaacttga catgggagag gaaacgtgta ggacccgctg    360

aggaatgctt ctgaacggcc tcggggaggg agcctgctgt aaagctgtca cagttaatgc    420

cagtgctact gtgcagaaag agaactcagc ccgtgagtcc ttgaaaccag ccctccgaac    480

ataaataagc agccgggttc agtgaagcac atgacgcagg cttcacctct gccagcgttt    540

ccatcccaga aagtcctgcg ggacagattc tcacagtccc cagtgagccc catccatgac    600

ccctgctcgc cccccacgtt tcccagatga cggcagctgg agagccttcc tccgacagcg    660

gccccaggcc acggagaggc ggccccgcag agagcggatg tttgtgaagc tcctcttgga    720

gggaaagctg cccccaacgc tgaacactcc cgtctcaagg cacagacagg ggagcggtca    780

caagccggcc agtccctttt acagccaaaa tcgggggctc agaacattct ttaatgattt    840

ccgagccacc gagtgcactg ggcggccccg tctctgtttt cattccctga gatgtggtgc    900

tttctctcct ggagccccgt gttggggacg cttcaaccgc aggccttgcc tccctcccac    960

agtgctgagg aaggacaggc cctcccttcc ccaggaaagg ccaggctgga ggagcccagg   1020

tgtgggggga agttctgagc tggcattgtc acccccgggt ctagtatccc cacagagtgg   1080

accctggccc tgagcccagg ctgtgcctcc cctatgtgca gccgctggga tgtgtccagg   1140

gcagcacagg aggcaggtgc ccaggtactc ccctaggca                          1179


<210>  1024
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  1024

Met Thr Pro Ala Arg Pro Pro Arg Phe Pro Asp Asp Gly Ser Trp Arg 
1               5                   10                  15      


Ala Phe Leu Arg Gln Arg Pro Gln Ala Thr Glu Arg Arg Pro Arg Arg 
            20                  25                  30          


Glu Arg Met Phe Val Lys Leu Leu Leu Glu Gly Lys Leu Pro Pro Thr 
        35                  40                  45              


Leu Asn Thr Pro Val Ser Arg His Arg Gln Gly Ser Gly His Lys Pro 
    50                  55                  60                  


Ala Ser Pro Phe Tyr Ser Gln Asn Arg Gly Leu Arg Thr Phe Phe Asn 
65                  70                  75                  80  


Asp Phe Arg Ala Thr Glu Cys Thr Gly Arg Pro Arg Leu Cys Phe His 
                85                  90                  95      


Ser Leu Arg Cys Gly Ala Phe Ser Pro Gly Ala Pro Cys Trp Gly Arg 
            100                 105                 110         


Phe Asn Arg Arg Pro Cys Leu Pro Pro Thr Val Leu Arg Lys Asp Arg 
        115                 120                 125             


Pro Ser Leu Pro Gln Glu Arg Pro Gly Trp Arg Ser Pro Gly Val Gly 
    130                 135                 140                 


Gly Ser Ser Glu Leu Ala Leu Ser Pro Pro Gly Leu Val Ser Pro Gln 
145                 150                 155                 160 


Ser Gly Pro Trp Pro 
                165 


<210>  1025
<211>  2321
<212>  DNA
<213>  Homosapiens

<400>  1025
gcaccctggc tgctcgcatc tgcaggaagc atggtggggc tgggcggtcc caggctgccg     60

tggccccttt gtgctgctgt aagaaggtac ctgtgactgg gtgactcata aggagcagaa    120

atgtactgct cacagctctg gagtctggga agtctgaaac cagggccccg gcaggtttgg    180

tgtttggcga ggactgctct ctgcttccaa ggtggtcccc ttgttactgt gtcctctcat    240

agcagaaggc aggagggcaa aaggggcctg gccagtcaga cagccctttc gtaaggctct    300

aatcctaccc ttgacggtgg aaccctcacg gcctaaccct cccgaaggcc tcacctctga    360

acactgttgc gctggggatt aagtttcaac atggatttcg gaggaacaca gacattgaaa    420

ccacagcagt gccatcgctc ccaggctgag acccaccttg gctctctgcc cctagcatct    480

cctccctggc ccctggagag acacaggaga aggagagaag ggctattctg taggaatcac    540

aaggccgagt ggactctcac ctgagggagg gcacctgcag cttggctggc cccagggatc    600

tgtgggcacg gagcatgtgg ctgggtgcct atcaccttct tccccacttt accctgggca    660

tccagcccct ggaccatgac tgccaggcac ggagcaggtg tggaggagtg tcagcatgat    720

gaaattcacc cacaccacgg ctgccacaga tggacagcct cacggagagg tgccgcccac    780

agcccctcgc tgccctgggt ccagctgatg ctcagctcca tggtccggcc gctgctggtg    840

gcggtgttgg cccaagggtg atgctctcct ccctctgccg ggaacacccc tggcaaggac    900

gctgcccacc catccccgca catggaaagg aggtgaggca gctgcggcat cttcacagaa    960

cacgtccccc cgacacgcac caagacatgg ctcgaggccc gggcctccca cacacccatg   1020

ggcttccagc acgtccttcc cacgtcagac accagacaga gccggtgcag gtggcttcca   1080

ggtggcatgt cccttcggat gggctctgcc gtccctgtca tgtgcaccag ctgctgcatc   1140

cacccttagt gccagctctg ggggcctaag caggagctca gggacatgga gaccgtggag   1200

aggaggcatt cactgtgggg tgtcccaagg ctgggcacca aggcaggacc tccgtgtgcc   1260

ccgaatgccg gcttccctgg agactgcagc cagcggggat ctctcacatc agcctcccaa   1320

gaccaccgtg aggggggcgc ttaggagcag aaacacccag gccgagcagg atgagcaggt   1380

gaagctgccc aacgcagggg acgggacgca gaggcgattc acgagcctgg ggctccagca   1440

gcagccaggc ggatcccgcc acacctttcg ctctcagcta ccagtctgcc tgccaccatc   1500

accttcccgc gtgtgagtgg ggccctggtt ccccaagcag ccgctgactc ccggacgcct   1560

gctggccagg ccccggtcat gagtgcatcc ggggaaggct tcgggcctac aggaacggaa   1620

ggaaaagcca tccagcctcc ctgaccctcc acacggaagc tgaggggttc cccatacacc   1680

ggctgccggg gactgcctcg actctggttt tggcagagac aggccctgct gtgtccgtca   1740

tctctgatgg aagtgacagc catttcccct gcagacaggc cagagcggcc tatccacgct   1800

ccacggtgtg aggccagtgg tggcgtcccc agggccacag cccagcgagg gtgaggtggg   1860

ggagcgtcct ggctgagggc tggccgcctc ccgcgtgctc tggggaacaa tgcttccgca   1920

ccacccccgc cccttcctgg cttctgtgaa actgaacatc tccaagtaaa tattttcact   1980

gctaagcaca ggcagcactt cgaggcttcg tgacgaagac gtggaatgct tgaccctcac   2040

ctctcacctc tcacctctgc aggtcctggg cgcagacttc accttctgga ccttctccta   2100

tccggaaagt atgtggctca cacggtggtg caaggagcct tgggctgggc agctgctggc   2160

ctggatccga gtcctgccct ggtgaaagtg ctgattactt tacatacttc tacatctgca   2220

gaaccaggtg attgatcctc aaagcccagc cagctccagc aagctctggt acctgcaacc   2280

acgggccgcc ctgtgcccgg cccaccttcc tcgaaccgtg t                       2321


<210>  1026
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  1026

Met Asp Ser Leu Thr Glu Arg Cys Arg Pro Gln Pro Leu Ala Ala Leu 
1               5                   10                  15      


Gly Pro Ala Asp Ala Gln Leu His Gly Pro Ala Ala Ala Gly Gly Gly 
            20                  25                  30          


Val Gly Pro Arg Val Met Leu Ser Ser Leu Cys Arg Glu His Pro Trp 
        35                  40                  45              


Gln Gly Arg Cys Pro Pro Ile Pro Ala His Gly Lys Glu Val Arg Gln 
    50                  55                  60                  


Leu Arg His Leu His Arg Thr Arg Pro Pro Asp Thr His Gln Asp Met 
65                  70                  75                  80  


Ala Arg Gly Pro Gly Leu Pro His Thr His Gly Leu Pro Ala Arg Pro 
                85                  90                  95      


Ser His Val Arg His Gln Thr Glu Pro Val Gln Val Ala Ser Arg Trp 
            100                 105                 110         


His Val Pro Ser Asp Gly Leu Cys Arg Pro Cys His Val His Gln Leu 
        115                 120                 125             


Leu His Pro Pro Leu Val Pro Ala Leu Gly Ala 
    130                 135                 


<210>  1027
<211>  858
<212>  DNA
<213>  Homosapiens

<400>  1027
atgggagggc ctggtgtccc gacaatgccc tgggcccaac tcctcggccc ccaggagaac     60

ccagaggagg gctgggccct cccactccag ggactcggct tttctatgct ctcctattta    120

aacagacata gtgtctgtgc tatgctgggc cccaagggta agtcacagag gcctgaaatc    180

gaggatgagg ccgagcggag cctgggcaat ccaaacttca tcccattgac caacgacgag    240

ctggaattcc acaggacagt ctgtggccac cagaaaatcc tccatggcct ctgccacagg    300

ctctgtctga ctgtggagca gatggatgtt tccgcgaaca cagtacaaca agcaaaaacc    360

tgtaccaaca ctaaattcat ttttcatcct aacactcacc tagagattat tttggatttt    420

ctacaaacac aatgcacttc ctgccgtgct tgtgttggga aatctgccag aacccacagg    480

agggaaagtc taatgaaagc acgcgcctgc tggaaaacga accgggcttt tgaaaagaga    540

ggggctgcgt ttgtgctgac acgagcaaga gacctgtatt gccttaacac tcccagcaat    600

gaccacctgc aagcttgcgc tgcgactccc gtccgaagac atgcgggcca gtatgagcgg    660

agaggttccc agcaccgtca caagaccctg tgctattatt ttagactcac ctgtggctgt    720

tgacaacacc acacacatga aatgatgctc accagaatca aaatactcag ctaaacaaag    780

aattgtgttg gtcatgaaat tattaccagg agggataaaa ctccagggtg agccattaaa    840

gaatctgaat tcaattca                                                  858


<210>  1028
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  1028

Met Gly Gly Pro Gly Val Pro Thr Met Pro Trp Ala Gln Leu Leu Gly 
1               5                   10                  15      


Pro Gln Glu Asn Pro Glu Glu Gly Trp Ala Leu Pro Leu Gln Gly Leu 
            20                  25                  30          


Gly Phe Ser Met Leu Ser Tyr Leu Asn Arg His Ser Val Cys Ala Met 
        35                  40                  45              


Leu Gly Pro Lys Gly Lys Ser Gln Arg Pro Glu Ile Glu Asp Glu Ala 
    50                  55                  60                  


Glu Arg Ser Leu Gly Asn Pro Asn Phe Ile Pro Leu Thr Asn Asp Glu 
65                  70                  75                  80  


Leu Glu Phe His Arg Thr Val Cys Gly His Gln Lys Ile Leu His Gly 
                85                  90                  95      


Leu Cys His Arg Leu Cys Leu Thr Val Glu Gln Met Asp Val Ser Ala 
            100                 105                 110         


Asn Thr Val Gln Gln Ala Lys Thr Cys Thr Asn Thr Lys Phe Ile Phe 
        115                 120                 125             


His Pro Asn Thr His Leu Glu Ile Ile Leu Asp Phe Leu Gln Thr Gln 
    130                 135                 140                 


Cys Thr Ser Cys Arg Ala Cys Val Gly Lys Ser Ala Arg Thr His Arg 
145                 150                 155                 160 


Arg Glu Ser Leu Met Lys Ala Arg Ala Cys Trp Lys Thr Asn Arg Ala 
                165                 170                 175     


Phe Glu Lys Arg Gly Ala Ala Phe Val Leu Thr Arg Ala Arg Asp Leu 
            180                 185                 190         


Tyr Cys Leu Asn Thr Pro Ser Asn Asp His Leu Gln Ala Cys Ala Ala 
        195                 200                 205             


Thr Pro Val Arg Arg His Ala Gly Gln Tyr Glu Arg Arg Gly Ser Gln 
    210                 215                 220                 


His Arg His Lys Thr Leu Cys Tyr Tyr Phe Arg Leu Thr Cys Gly Cys 
225                 230                 235                 240 


<210>  1029
<211>  5910
<212>  DNA
<213>  Homosapiens

<400>  1029
agctccagcc gcactgcccc gatggctccc tacccctgtg gctgccacat cctgctgctg     60

ctcttctgct gcctggcggc tgcccgggcc aacctgctga acctgaactg gctttggttc    120

aataatgagg acaccagcca cgcagctacc acgatccctg agccccaggg gcccctgcct    180

gtgcagccca cagcagatac caccacacac gtgacccccc ggaatggttc cacagagcca    240

gcgacagccc ctggcagccc tgagccaccc tcagagctgc tggaagatgg ccaggacacc    300

cccacttctg ccgagagccc ggacgcgcca gaggagaaca ttgccggtgt cggagccgag    360

atcctgaacg tggccaaagg catccggagc ttcgtccagc tgtggaatga cactgtcccc    420

actgagagct tggccagggc ggaaaccctg gtcctggaga ctcctgtggg cccccttgcc    480

ctcgctgggc cttccagcac cccccaggag aatgggacca ctctctggcc cagccgtggc    540

attcctagct ctccgggcgc ccacacaacc gaggctggca ccttgcctgc acccacccca    600

tcgcctccgt ccctgggcag gccctgggca ccactcacgg ggccctcagt gccaccacca    660

tcttcagagc gcatcagcga ggaggtgggg ctgctgcagc tccttgggga ccccccgccc    720

cagcaggtca cccagacgga tgaccccgac gtcgggctgg cctacgtctt tgggccagat    780

gccaacagtg gccaagtggc ccggtaccac ttccccagcc tcttcttccg tgacttctca    840

ctgctgttcc acatccggcc agccacagag ggcccagggg tgctgttcgc catcacggac    900

tcggcgcagg ccatggtctt gctgggcgtg aagctctctg gggtgcagga cgggcaccag    960

gacatctccc tgctctacac agaacctggt gcaggccaga cccacacagc cgccagcttc   1020

cggctccccg ccttcgtcgg ccagtggaca cacttagccc tcagtgtggc aggtggcttt   1080

gtggccctct acgtggactg tgaggagttc cagagaatgc cgcttgctcg gtcctcacgg   1140

ggcctggagc tggagcctgg cgccgggctc ttcgtggctc aggcgggggg agcggaccct   1200

gacaagttcc agggggtgat cgctgagctg aaggtgcgca gggaccccca ggtgagcccc   1260

atgcactgcc tggacgagga aggcgatgac tcagatgggg cattcggaga ctctggcagc   1320

gggctcgggg acgcccggga gcttctcagg gaggagacgg gcgcggccct aaaacccagg   1380

ctccccgcgc caccccccgt caccacgcca cccttggctg gaggcagcag cacggaagat   1440

tccagaagtg aagaagtcga ggagcagacc acggtggctt cgttaggagc tcagacactt   1500

cctggctcag attctgtctc cacgtgggac gggagtgtcc ggacccctgg gggccgcgtg   1560

aaagagggcg gcctgaaggg gcagaaaggg gagccaggtg ttccgggccc acctggccgg   1620

gcaggccccc caggatcccc atgcctacct ggtcccccgg gtctcccgtg cccagtgagt   1680

cccctgggtc ctgcaggccc agcgttgcaa actgtccccg gaccacaagg acccccaggg   1740

cctccgggga gggacggcac ccctggaagg gacggcgagc cgggcgaccc cggtgaagac   1800

ggaaagccgg gcgacaccgg gccacaaggc ttccctggga ctccagggga tgtaggtccc   1860

aagggagaca agggagaccc tggggttgga gagagagggc ccccaggacc ccaagggcct   1920

ccagggcccc caggaccctc cttcagacac gacaagctga ccttcattga catggaggga   1980

tctggctttg ggggcgatct ggaggccctg cggggtcctc gaggcttccc tggacctccc   2040

ggaccccccg gtgtcccagg cctgcccggc gagccaggcc gctttggggt gaacagctcc   2100

gacgtcccag gacccgccgg ccttcctggt gtgcctgggc gcgagggtcc ccccgggttt   2160

cctggcctcc cgggaccccc aggccctccg ggaagagagg ggcccccagg aaggactggg   2220

cagaaaggca gcctgggtga agcaggcgcc ccaggacata aggggagcaa gggagccccc   2280

ggtcctgctg gtgctcgtgg ggagagcggc ctggcaggag cccccggacc tgctggacca   2340

ccaggccccc ctgggccccc tgggccccca ggaccaggac tccccgctgg atttgatgac   2400

atggaaggct ccggggggcc cttctggtca acagcccgaa gcgctgatgg gccacaggga   2460

cctcccggcc tgccgggact taagggggat cctggcgtgc ctgggctgcc gggggcgaag   2520

ggagaagttg gagcagatgg aatccccggg ttccccggcc tccctggcag agagggcatt   2580

gctgggcccc aggggccaaa gggagacaga ggcagccggg gagaaaaggg agatccaggg   2640

aaggacggag tcgggcagcc gggcctccct ggcccccccg gacccccggg acctgtggtc   2700

tacgtgtcgg agcaggacgg atccgtcctg agcgtgccgg gacctgaggg ccggccgggt   2760

ttcgcaggct ttcccggacc tgcaggaccc aagggcaacc tgggctctaa gggcgaacga   2820

ggctccccgg gacccaaggg tgagaagggt gaaccgggca gcatcttcag ccccgacggc   2880

ggtgccctgg gccctgccca gaaaggagcc aagggagagc cgggcttccg aggacccccg   2940

ggtccatacg gacggccggg gtacaaggga gagattggct ttcctggacg gccgggtcgc   3000

cccgggatga acggattgaa aggagagaaa ggggagccgg gagatgccag ccttggattt   3060

ggcatgaggg gaatgcccgg ccccccagga cctccagggc ccccaggccc tccagggact   3120

cctgtttacg acagcaatgt gtttgctgag tccagccgcc ccgggcctcc aggattgcca   3180

gggaatcagg gccctccagg acccaagggc gccaaaggag aagtgggccc ccccggacca   3240

ccagggcagt ttccgtttga ctttcttcag ttggaggctg aaatgaaggg ggagaaggga   3300

gaccgaggtg atgcaggaca gaaaggcgaa aggggggagc ccgggggcgg cggtttcttc   3360

ggctccagcc tgcccggccc ccccggcccc ccaggcccac gtggctaccc tgggattcca   3420

ggtcccaagg gagagagcat ccggggccag cccggcccac ctggacctca gggacccccc   3480

ggcatcggct acgaggggcg ccagggccct cccggccccc caggcccccc agggccccct   3540

tcatttcctg gccctcacag gcagactatc agcgttcccg gccctccggg cccccctggg   3600

ccccctgggc cccctggaac catgggcgcc tcctcagggg tgaggctctg ggctacacgc   3660

caggccatgc tgggccaggt gcacgaggtt cccgagggct ggctcatctt cgtggccgag   3720

caggaggagc tctacgtccg cgtgcagaac gggttccgga aggtccagct ggaggcccgg   3780

acaccactcc cacgagggac ggacaatgaa gtggccgcct tgcagccccc cgtggtgcag   3840

ctgcacgaca gcaaccccta cccgcggcgg gagcaccccc accccaccgc gcggccctgg   3900

cgggcagatg acatcctggc cagcccccct cgcctgcccg agccccagcc ctaccccgga   3960

gccccgcacc acagctccta cgtgcacctg cggccggcgc gacccacaag cccacccgcc   4020

cacagccacc gcgacttcca gccggtgctc cacctggttg cgctcaacag ccccctgtca   4080

ggcggcatgc ggggcatccg cggggccgac ttccagtgct tccagcaggc gcgggccgtg   4140

gggctggcgg gcaccttccg cgccttcctg tcctcgcgcc tgcaggacct gtacagcatc   4200

gtgcgccgtg ccgaccgcgc agccgtgccc atcgtcaacc tcaaggacga gctgctgttt   4260

cccagctggg aggctctgtt ctcaggctct gagggtccgc tgaagcccgg ggcacgcatc   4320

ttctcctttg acggcaagga cgtcctgagg caccccacct ggccccagaa gagcgtgtgg   4380

catggctcgg accccaacgg gcgcaggctg accgagagct actgtgagac gtggcggacg   4440

gaggctccct cggccacggg ccaggcctcc tcgctgctgg ggggcaggct cctggggcag   4500

agtgccgcga gctgccatca cgcctacatc gtgctctgca ttgagaacag cttcatgact   4560

gcctccaagt agccaccgcc tggatgcgga tggccggaga ggaccggcgg ctcggaggaa   4620

gcccccaccg tgggcaggga gcggccggcc agcccctggc cccaggacct ggctgccata   4680

ctttcctgta tagttcacgt ttcatgtaat cctcaagaaa taaaaggaag ccaaagagtg   4740

tattttttta aaagtttaaa acagaagcct gatgctgaca ttcacctgcc ccaactctcc   4800

cctgacctgt gagcccagct gggtcaggca gggtgcagta tcatgccctg tgcaacctct   4860

tggcctgatc agaccacggc tcgatttctc caggatttcc tgctttggga agccgtgctc   4920

gccccagcag gtgctgactt catctcccac ctagcagcac cgttctgtgc acaaaaccca   4980

gacctgttag cagacaggcc ccgtgaggca atgggagctg aggccacact cagcacaagg   5040

ccatctgggc tcctccaggg tgtgtgctcg ccctgcggta gatgggaggg aggctcaggt   5100

ccctggggct agggggagcc ccttctgctc agctctgggc cattctccac agcaacccca   5160

ggctgaagca ggttcccaag ctcagaggcg cactgtgacc cccagctccg gcctgtcctc   5220

caacaccaag cacagcagcc tggggctggc ctcccaaatg agccatgaga tgatacatcc   5280

aaagcagaca gctccaccct ggccgagtcc aagctgggag attcaaggga cccatgagtt   5340

ggggtctggc agcctcccat ccagggcccc catctcatgc ccctggctgg gacgtggctc   5400

agccagcact tgtccagctg agcgccagga tggaacacgg ccacatcaaa gaggctgagg   5460

ctggcacagg acatgcggta gccagcacac agggcagtga gggagggctg tcatctgtgc   5520

actgcccatg gacaggctgg ctccagatgc agggcagtca ttggctgtct cctaggaaac   5580

ccatatcctt accctccttg ggactgaagg ggaaccccgg ggtgcccaca ggccgccctg   5640

cgggtgaaca aagcagccac gaggtgcaac aaggtcctct gtcagtcaca gccacccctg   5700

agatccggca acatcaaccc gagtcattcg ttctgtggag ggacaagtgg actcagggca   5760

gcgccaggct gaccacagca cagccaacac gcacctgcct caggactgcg acgaaaccgg   5820

tggggctggt tctgtaattg tgtgtgatgt gaagccaatt cagacaggca aataaaagtg   5880

accttttaca ctgaaaaaaa aaaaaaaaaa                                    5910


<210>  1030
<211>  1516
<212>  PRT
<213>  Homosapiens

<400>  1030

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Phe Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 
    530                 535                 540                 


Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 
            580                 585                 590         


Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 
        595                 600                 605             


Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 
    610                 615                 620                 


Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 
625                 630                 635                 640 


Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 
                645                 650                 655     


Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 
            660                 665                 670         


Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 
    690                 695                 700                 


Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 
                725                 730                 735     


Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 
        755                 760                 765             


Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 
785                 790                 795                 800 


Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 
            820                 825                 830         


Lys Gly Glu Val Gly Ala Asp Gly Ile Pro Gly Phe Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 
    850                 855                 860                 


Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 
                885                 890                 895     


Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 
            900                 905                 910         


Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 
        915                 920                 925             


Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 
    930                 935                 940                 


Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 
945                 950                 955                 960 


Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 
                965                 970                 975     


Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 
            980                 985                 990         


Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 
        995                 1000                 1005             


Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 
    1025                 1030                 1035             


Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 
    1055                 1060                 1065             


Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 
    1085                 1090                 1095             


Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 
    1100                 1105                 1110             


Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly 
    1115                 1120                 1125             


Tyr Pro  Gly Ile Pro Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu 
    1145                 1150                 1155             


Gly Arg  Gln Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1160                 1165                 1170             


Ser Phe  Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1190                 1195                 1200             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1205                 1210                 1215             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1220                 1225                 1230             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1235                 1240                 1245             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1250                 1255                 1260             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1265                 1270                 1275             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1280                 1285                 1290             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1295                 1300                 1305             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1310                 1315                 1320             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1325                 1330                 1335             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1340                 1345                 1350             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1355                 1360                 1365             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1370                 1375                 1380             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1385                 1390                 1395             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1400                 1405                 1410             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1415                 1420                 1425             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1430                 1435                 1440             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1445                 1450                 1455             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1460                 1465                 1470             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1475                 1480                 1485             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1490                 1495                 1500             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1505                 1510                 1515     


<210>  1031
<211>  5781
<212>  DNA
<213>  Homosapiens

<400>  1031
agctccagcc gcactgcccc gatggctccc tacccctgtg gctgccacat cctgctgctg     60

ctcttctgct gcctggcggc tgcccgggcc aacctgctga acctgaactg gctttggttc    120

aataatgagg acaccagcca cgcagctacc acgatccctg agccccaggg gcccctgcct    180

gtgcagccca cagcagatac caccacacac gtgacccccc ggaatggttc cacagagcca    240

gcgacagccc ctggcagccc tgagccaccc tcagagctgc tggaagatgg ccaggacacc    300

cccacttctg ccgagagccc ggacgcgcca gaggagaaca ttgccggtgt cggagccgag    360

atcctgaacg tggccaaagg catccggagc ttcgtccagc tgtggaatga cactgtcccc    420

actgagagct tggccagggc ggaaaccctg gtcctggaga ctcctgtggg cccccttgcc    480

ctcgctgggc cttccagcac cccccaggag aatgggacca ctctctggcc cagccgtggc    540

attcctagct ctccgggcgc ccacacaacc gaggctggca ccttgcctgc acccacccca    600

tcgcctccgt ccctgggcag gccctgggca ccactcacgg ggccctcagt gccaccacca    660

tcttcagagc gcatcagcga ggaggtgggg ctgctgcagc tccttgggga ccccccgccc    720

cagcaggtca cccagacgga tgaccccgac gtcgggctgg cctacgtctt tgggccagat    780

gccaacagtg gccaagtggc ccggtaccac ttccccagcc tcttcttccg tgacttctca    840

ctgctgttcc acatccggcc agccacagag ggcccagggg tgctgttcgc catcacggac    900

tcggcgcagg ccatggtctt gctgggcgtg aagctctctg gggtgcagga cgggcaccag    960

gacatctccc tgctctacac agaacctggt gcaggccaga cccacacagc cgccagcttc   1020

cggctccccg ccttcgtcgg ccagtggaca cacttagccc tcagtgtggc aggtggcttt   1080

gtggccctct acgtggactg tgaggagttc cagagaatgc cgcttgctcg gtcctcacgg   1140

ggcctggagc tggagcctgg cgccgggctc ttcgtggctc aggcgggggg agcggaccct   1200

gacaagttcc agggggtgat cgctgagctg aaggtgcgca gggaccccca ggtgagcccc   1260

atgcactgcc tggacgagga aggcgatgac tcagatgggg cattcggaga ctctggcagc   1320

gggctcgggg acgcccggga gcttctcagg gaggagacgg gcgcggccct aaaacccagg   1380

ctccccgcgc caccccccgt caccacgcca cccttggctg gaggcagcag cacggaagat   1440

tccagaagtg aagaagtcga ggagcagacc acggtggctt cgttaggagc tcagacactt   1500

cctggctcag attctgtctc cacgtgggac gggagtgtcc ggacccctgg gggccgcgtg   1560

aaagagggcg gcctgaaggg gcagaaaggg gagccaggtg ttccggcagg gcctccgggg   1620

agggacggca cccctggaag ggacggcgag ccgggcgacc ccggtgaaga cggaaagccg   1680

ggcgacaccg ggccacaagg cttccctggg actccagggg atgtaggtcc caagggagac   1740

aagggagacc ctggggttgg agagagaggg cccccaggac cccaagggcc tccagggccc   1800

ccaggaccct ccttcagaca cgacaagctg accttcattg acatggaggg atctggcttt   1860

gggggcgatc tggaggccct gcggggtcct cgaggcttcc ctggacctcc cggacccccc   1920

ggtgtcccag gcctgcccgg cgagccaggc cgctttgggg tgaacagctc cgacgtccca   1980

ggacccgccg gccttcctgg tgtgcctggg cgcgagggtc cccccgggtt tcctggcctc   2040

ccgggacccc caggccctcc gggaagagag gggcccccag gaaggactgg gcagaaaggc   2100

agcctgggtg aagcaggcgc cccaggacat aaggggagca agggagcccc cggtcctgct   2160

ggtgctcgtg gggagagcgg cctggcagga gcccccggac ctgctggacc accaggcccc   2220

cctgggcccc ctgggccccc aggaccagga ctccccgctg gatttgatga catggaaggc   2280

tccggggggc ccttctggtc aacagcccga agcgctgatg ggccacaggg acctcccggc   2340

ctgccgggac ttaaggggga tcctggcgtg cctgggctgc cgggggcgaa gggagaagtt   2400

ggagcagatg gaatccccgg gttccccggc ctccctggca gagagggcat tgctgggccc   2460

caggggccaa agggagacag aggcagccgg ggagaaaagg gagatccagg gaaggacgga   2520

gtcgggcagc cgggcctccc tggccccccc ggacccccgg gacctgtggt ctacgtgtcg   2580

gagcaggacg gatccgtcct gagcgtgccg ggacctgagg gccggccggg tttcgcaggc   2640

tttcccggac ctgcaggacc caagggcaac ctgggctcta agggcgaacg aggctccccg   2700

ggacccaagg gtgagaaggg tgaaccgggc agcatcttca gccccgacgg cggtgccctg   2760

ggccctgccc agaaaggagc caagggagag ccgggcttcc gaggaccccc gggtccatac   2820

ggacggccgg ggtacaaggg agagattggc tttcctggac ggccgggtcg ccccgggatg   2880

aacggattga aaggagagaa aggggagccg ggagatgcca gccttggatt tggcatgagg   2940

ggaatgcccg gccccccagg acctccaggg cccccaggcc ctccagggac tcctgtttac   3000

gacagcaatg tgtttgctga gtccagccgc cccgggcctc caggattgcc agggaatcag   3060

ggccctccag gacccaaggg cgccaaagga gaagtgggcc cccccggacc accagggcag   3120

tttccgtttg actttcttca gttggaggct gaaatgaagg gggagaaggg agaccgaggt   3180

gatgcaggac agaaaggcga aaggggggag cccgggggcg gcggtttctt cggctccagc   3240

ctgcccggcc cccccggccc cccaggccca cgtggctacc ctgggattcc aggtcccaag   3300

ggagagagca tccggggcca gcccggccca cctggacctc agggaccccc cggcatcggc   3360

tacgaggggc gccagggccc tcccggcccc ccaggccccc cagggccccc ttcatttcct   3420

ggccctcaca ggcagactat cagcgttccc ggccctccgg gcccccctgg gccccctggg   3480

ccccctggaa ccatgggcgc ctcctcaggg gtgaggctct gggctacacg ccaggccatg   3540

ctgggccagg tgcacgaggt tcccgagggc tggctcatct tcgtggccga gcaggaggag   3600

ctctacgtcc gcgtgcagaa cgggttccgg aaggtccagc tggaggcccg gacaccactc   3660

ccacgaggga cggacaatga agtggccgcc ttgcagcccc ccgtggtgca gctgcacgac   3720

agcaacccct acccgcggcg ggagcacccc caccccaccg cgcggccctg gcgggcagat   3780

gacatcctgg ccagcccccc tcgcctgccc gagccccagc cctaccccgg agccccgcac   3840

cacagctcct acgtgcacct gcggccggcg cgacccacaa gcccacccgc ccacagccac   3900

cgcgacttcc agccggtgct ccacctggtt gcgctcaaca gccccctgtc aggcggcatg   3960

cggggcatcc gcggggccga cttccagtgc ttccagcagg cgcgggccgt ggggctggcg   4020

ggcaccttcc gcgccttcct gtcctcgcgc ctgcaggacc tgtacagcat cgtgcgccgt   4080

gccgaccgcg cagccgtgcc catcgtcaac ctcaaggacg agctgctgtt tcccagctgg   4140

gaggctctgt tctcaggctc tgagggtccg ctgaagcccg gggcacgcat cttctccttt   4200

gacggcaagg acgtcctgag gcaccccacc tggccccaga agagcgtgtg gcatggctcg   4260

gaccccaacg ggcgcaggct gaccgagagc tactgtgaga cgtggcggac ggaggctccc   4320

tcggccacgg gccaggcctc ctcgctgctg gggggcaggc tcctggggca gagtgccgcg   4380

agctgccatc acgcctacat cgtgctctgc attgagaaca gcttcatgac tgcctccaag   4440

tagccaccgc ctggatgcgg atggccggag aggaccggcg gctcggagga agcccccacc   4500

gtgggcaggg agcggccggc cagcccctgg ccccaggacc tggctgccat actttcctgt   4560

atagttcacg tttcatgtaa tcctcaagaa ataaaaggaa gccaaagagt gtattttttt   4620

aaaagtttaa aacagaagcc tgatgctgac attcacctgc cccaactctc ccctgacctg   4680

tgagcccagc tgggtcaggc agggtgcagt atcatgccct gtgcaacctc ttggcctgat   4740

cagaccacgg ctcgatttct ccaggatttc ctgctttggg aagccgtgct cgccccagca   4800

ggtgctgact tcatctccca cctagcagca ccgttctgtg cacaaaaccc agacctgtta   4860

gcagacaggc cccgtgaggc aatgggagct gaggccacac tcagcacaag gccatctggg   4920

ctcctccagg gtgtgtgctc gccctgcggt agatgggagg gaggctcagg tccctggggc   4980

tagggggagc cccttctgct cagctctggg ccattctcca cagcaacccc aggctgaagc   5040

aggttcccaa gctcagaggc gcactgtgac ccccagctcc ggcctgtcct ccaacaccaa   5100

gcacagcagc ctggggctgg cctcccaaat gagccatgag atgatacatc caaagcagac   5160

agctccaccc tggccgagtc caagctggga gattcaaggg acccatgagt tggggtctgg   5220

cagcctccca tccagggccc ccatctcatg cccctggctg ggacgtggct cagccagcac   5280

ttgtccagct gagcgccagg atggaacacg gccacatcaa agaggctgag gctggcacag   5340

gacatgcggt agccagcaca cagggcagtg agggagggct gtcatctgtg cactgcccat   5400

ggacaggctg gctccagatg cagggcagtc attggctgtc tcctaggaaa cccatatcct   5460

taccctcctt gggactgaag gggaaccccg gggtgcccac aggccgccct gcgggtgaac   5520

aaagcagcca cgaggtgcaa caaggtcctc tgtcagtcac agccacccct gagatccggc   5580

aacatcaacc cgagtcattc gttctgtgga gggacaagtg gactcagggc agcgccaggc   5640

tgaccacagc acagccaaca cgcacctgcc tcaggactgc gacgaaaccg gtggggctgg   5700

ttctgtaatt gtgtgtgatg tgaagccaat tcagacaggc aaataaaagt gaccttttac   5760

actgaaaaaa aaaaaaaaaa a                                             5781


<210>  1032
<211>  1473
<212>  PRT
<213>  Homosapiens

<400>  1032

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Phe Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Ala Gly Pro Pro Gly Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro 
    530                 535                 540                 


Gly Asp Pro Gly Glu Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly 
545                 550                 555                 560 


Phe Pro Gly Thr Pro Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp 
                565                 570                 575     


Pro Gly Val Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
            580                 585                 590         


Pro Pro Gly Pro Ser Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met 
        595                 600                 605             


Glu Gly Ser Gly Phe Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg 
    610                 615                 620                 


Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Pro Gly Arg Phe Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala 
                645                 650                 655     


Gly Leu Pro Gly Val Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly 
            660                 665                 670         


Leu Pro Gly Pro Pro Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg 
        675                 680                 685             


Thr Gly Gln Lys Gly Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys 
    690                 695                 700                 


Gly Ser Lys Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly 
705                 710                 715                 720 


Leu Ala Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro 
                725                 730                 735     


Pro Gly Pro Pro Gly Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu 
            740                 745                 750         


Gly Ser Gly Gly Pro Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro 
        755                 760                 765             


Gln Gly Pro Pro Gly Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro 
    770                 775                 780                 


Gly Leu Pro Gly Ala Lys Gly Glu Val Gly Ala Asp Gly Ile Pro Gly 
785                 790                 795                 800 


Phe Pro Gly Leu Pro Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro 
                805                 810                 815     


Lys Gly Asp Arg Gly Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp 
            820                 825                 830         


Gly Val Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro 
        835                 840                 845             


Val Val Tyr Val Ser Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly 
    850                 855                 860                 


Pro Glu Gly Arg Pro Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro 
865                 870                 875                 880 


Lys Gly Asn Leu Gly Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys 
                885                 890                 895     


Gly Glu Lys Gly Glu Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala 
            900                 905                 910         


Leu Gly Pro Ala Gln Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly 
        915                 920                 925             


Pro Pro Gly Pro Tyr Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe 
    930                 935                 940                 


Pro Gly Arg Pro Gly Arg Pro Gly Met Asn Gly Leu Lys Gly Glu Lys 
945                 950                 955                 960 


Gly Glu Pro Gly Asp Ala Ser Leu Gly Phe Gly Met Arg Gly Met Pro 
                965                 970                 975     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Pro Val 
            980                 985                 990         


Tyr Asp Ser Asn Val Phe Ala Glu  Ser Ser Arg Pro Gly  Pro Pro Gly 
        995                 1000                 1005             


Leu Pro  Gly Asn Gln Gly Pro  Pro Gly Pro Lys Gly  Ala Lys Gly 
    1010                 1015                 1020             


Glu Val  Gly Pro Pro Gly Pro  Pro Gly Gln Phe Pro  Phe Asp Phe 
    1025                 1030                 1035             


Leu Gln  Leu Glu Ala Glu Met  Lys Gly Glu Lys Gly  Asp Arg Gly 
    1040                 1045                 1050             


Asp Ala  Gly Gln Lys Gly Glu  Arg Gly Glu Pro Gly  Gly Gly Gly 
    1055                 1060                 1065             


Phe Phe  Gly Ser Ser Leu Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1070                 1075                 1080             


Arg Gly  Tyr Pro Gly Ile Pro  Gly Pro Lys Gly Glu  Ser Ile Arg 
    1085                 1090                 1095             


Gly Gln  Pro Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Ile Gly 
    1100                 1105                 1110             


Tyr Glu  Gly Arg Gln Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly 
    1115                 1120                 1125             


Pro Pro  Ser Phe Pro Gly Pro  His Arg Gln Thr Ile  Ser Val Pro 
    1130                 1135                 1140             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Thr Met 
    1145                 1150                 1155             


Gly Ala  Ser Ser Gly Val Arg  Leu Trp Ala Thr Arg  Gln Ala Met 
    1160                 1165                 1170             


Leu Gly  Gln Val His Glu Val  Pro Glu Gly Trp Leu  Ile Phe Val 
    1175                 1180                 1185             


Ala Glu  Gln Glu Glu Leu Tyr  Val Arg Val Gln Asn  Gly Phe Arg 
    1190                 1195                 1200             


Lys Val  Gln Leu Glu Ala Arg  Thr Pro Leu Pro Arg  Gly Thr Asp 
    1205                 1210                 1215             


Asn Glu  Val Ala Ala Leu Gln  Pro Pro Val Val Gln  Leu His Asp 
    1220                 1225                 1230             


Ser Asn  Pro Tyr Pro Arg Arg  Glu His Pro His Pro  Thr Ala Arg 
    1235                 1240                 1245             


Pro Trp  Arg Ala Asp Asp Ile  Leu Ala Ser Pro Pro  Arg Leu Pro 
    1250                 1255                 1260             


Glu Pro  Gln Pro Tyr Pro Gly  Ala Pro His His Ser  Ser Tyr Val 
    1265                 1270                 1275             


His Leu  Arg Pro Ala Arg Pro  Thr Ser Pro Pro Ala  His Ser His 
    1280                 1285                 1290             


Arg Asp  Phe Gln Pro Val Leu  His Leu Val Ala Leu  Asn Ser Pro 
    1295                 1300                 1305             


Leu Ser  Gly Gly Met Arg Gly  Ile Arg Gly Ala Asp  Phe Gln Cys 
    1310                 1315                 1320             


Phe Gln  Gln Ala Arg Ala Val  Gly Leu Ala Gly Thr  Phe Arg Ala 
    1325                 1330                 1335             


Phe Leu  Ser Ser Arg Leu Gln  Asp Leu Tyr Ser Ile  Val Arg Arg 
    1340                 1345                 1350             


Ala Asp  Arg Ala Ala Val Pro  Ile Val Asn Leu Lys  Asp Glu Leu 
    1355                 1360                 1365             


Leu Phe  Pro Ser Trp Glu Ala  Leu Phe Ser Gly Ser  Glu Gly Pro 
    1370                 1375                 1380             


Leu Lys  Pro Gly Ala Arg Ile  Phe Ser Phe Asp Gly  Lys Asp Val 
    1385                 1390                 1395             


Leu Arg  His Pro Thr Trp Pro  Gln Lys Ser Val Trp  His Gly Ser 
    1400                 1405                 1410             


Asp Pro  Asn Gly Arg Arg Leu  Thr Glu Ser Tyr Cys  Glu Thr Trp 
    1415                 1420                 1425             


Arg Thr  Glu Ala Pro Ser Ala  Thr Gly Gln Ala Ser  Ser Leu Leu 
    1430                 1435                 1440             


Gly Gly  Arg Leu Leu Gly Gln  Ser Ala Ala Ser Cys  His His Ala 
    1445                 1450                 1455             


Tyr Ile  Val Leu Cys Ile Glu  Asn Ser Phe Met Thr  Ala Ser Lys 
    1460                 1465                 1470             


<210>  1033
<211>  5398
<212>  DNA
<213>  Homosapiens

<400>  1033
cgcggcggag gaggcagcat cccgcggcgc tgacggtcct ggggagagca tggcgccgag     60

gtgcccctgg ccatggccgc ggcggcggcg cctcctggac gtgctcgcgc ccctggtcct    120

gctgctcggg gtccgcgcgg cctccgcgga gccagagcgc atcagcgagg aggtggggct    180

gctgcagctc cttggggacc ccccgcccca gcaggtcacc cagacggatg accccgacgt    240

cgggctggcc tacgtctttg ggccagatgc caacagtggc caagtggccc ggtaccactt    300

ccccagcctc ttcttccgtg acttctcact gctgttccac atccggccag ccacagaggg    360

cccaggggtg ctgttcgcca tcacggactc ggcgcaggcc atggtcttgc tgggcgtgaa    420

gctctctggg gtgcaggacg ggcaccagga catctccctg ctctacacag aacctggtgc    480

aggccagacc cacacagccg ccagcttccg gctccccgcc ttcgtcggcc agtggacaca    540

cttagccctc agtgtggcag gtggctttgt ggccctctac gtggactgtg aggagttcca    600

gagaatgccg cttgctcggt cctcacgggg cctggagctg gagcctggcg ccgggctctt    660

cgtggctcag gcggggggag cggaccctga caagttccag ggggtgatcg ctgagctgaa    720

ggtgcgcagg gacccccagg tgagccccat gcactgcctg gacgaggaag gcgatgactc    780

agatggggca ttcggagact ctggcagcgg gctcggggac gcccgggagc ttctcaggga    840

ggagacgggc gcggccctaa aacccaggct ccccgcgcca ccccccgtca ccacgccacc    900

cttggctgga ggcagcagca cggaagattc cagaagtgaa gaagtcgagg agcagaccac    960

ggtggcttcg ttaggagctc agacacttcc tggctcagat tctgtctcca cgtgggacgg   1020

gagtgtccgg acccctgggg gccgcgtgaa agagggcggc ctgaaggggc agaaagggga   1080

gccaggtgtt ccgggcccac ctggccgggc aggcccccca ggatccccat gcctacctgg   1140

tcccccgggt ctcccgtgcc cagtgagtcc cctgggtcct gcaggcccag cgttgcaaac   1200

tgtccccgga ccacaaggac ccccagggcc tccggggagg gacggcaccc ctggaaggga   1260

cggcgagccg ggcgaccccg gtgaagacgg aaagccgggc gacaccgggc cacaaggctt   1320

ccctgggact ccaggggatg taggtcccaa gggagacaag ggagaccctg gggttggaga   1380

gagagggccc ccaggacccc aagggcctcc agggccccca ggaccctcct tcagacacga   1440

caagctgacc ttcattgaca tggagggatc tggctttggg ggcgatctgg aggccctgcg   1500

gggtcctcga ggcttccctg gacctcccgg accccccggt gtcccaggcc tgcccggcga   1560

gccaggccgc tttggggtga acagctccga cgtcccagga cccgccggcc ttcctggtgt   1620

gcctgggcgc gagggtcccc ccgggtttcc tggcctcccg ggacccccag gccctccggg   1680

aagagagggg cccccaggaa ggactgggca gaaaggcagc ctgggtgaag caggcgcccc   1740

aggacataag gggagcaagg gagcccccgg tcctgctggt gctcgtgggg agagcggcct   1800

ggcaggagcc cccggacctg ctggaccacc aggcccccct gggccccctg ggcccccagg   1860

accaggactc cccgctggat ttgatgacat ggaaggctcc ggggggccct tctggtcaac   1920

agcccgaagc gctgatgggc cacagggacc tcccggcctg ccgggactta agggggatcc   1980

tggcgtgcct gggctgccgg gggcgaaggg agaagttgga gcagatggaa tccccgggtt   2040

ccccggcctc cctggcagag agggcattgc tgggccccag gggccaaagg gagacagagg   2100

cagccgggga gaaaagggag atccagggaa ggacggagtc gggcagccgg gcctccctgg   2160

cccccccgga cccccgggac ctgtggtcta cgtgtcggag caggacggat ccgtcctgag   2220

cgtgccggga cctgagggcc ggccgggttt cgcaggcttt cccggacctg caggacccaa   2280

gggcaacctg ggctctaagg gcgaacgagg ctccccggga cccaagggtg agaagggtga   2340

accgggcagc atcttcagcc ccgacggcgg tgccctgggc cctgcccaga aaggagccaa   2400

gggagagccg ggcttccgag gacccccggg tccatacgga cggccggggt acaagggaga   2460

gattggcttt cctggacggc cgggtcgccc cgggatgaac ggattgaaag gagagaaagg   2520

ggagccggga gatgccagcc ttggatttgg catgagggga atgcccggcc ccccaggacc   2580

tccagggccc ccaggccctc cagggactcc tgtttacgac agcaatgtgt ttgctgagtc   2640

cagccgcccc gggcctccag gattgccagg gaatcagggc cctccaggac ccaagggcgc   2700

caaaggagaa gtgggccccc ccggaccacc agggcagttt ccgtttgact ttcttcagtt   2760

ggaggctgaa atgaaggggg agaagggaga ccgaggtgat gcaggacaga aaggcgaaag   2820

gggggagccc gggggcggcg gtttcttcgg ctccagcctg cccggccccc ccggcccccc   2880

aggcccacgt ggctaccctg ggattccagg tcccaaggga gagagcatcc ggggccagcc   2940

cggcccacct ggacctcagg gaccccccgg catcggctac gaggggcgcc agggccctcc   3000

cggcccccca ggccccccag ggcccccttc atttcctggc cctcacaggc agactatcag   3060

cgttcccggc cctccgggcc cccctgggcc ccctgggccc cctggaacca tgggcgcctc   3120

ctcaggggtg aggctctggg ctacacgcca ggccatgctg ggccaggtgc acgaggttcc   3180

cgagggctgg ctcatcttcg tggccgagca ggaggagctc tacgtccgcg tgcagaacgg   3240

gttccggaag gtccagctgg aggcccggac accactccca cgagggacgg acaatgaagt   3300

ggccgccttg cagccccccg tggtgcagct gcacgacagc aacccctacc cgcggcggga   3360

gcacccccac cccaccgcgc ggccctggcg ggcagatgac atcctggcca gcccccctcg   3420

cctgcccgag ccccagccct accccggagc cccgcaccac agctcctacg tgcacctgcg   3480

gccggcgcga cccacaagcc cacccgccca cagccaccgc gacttccagc cggtgctcca   3540

cctggttgcg ctcaacagcc ccctgtcagg cggcatgcgg ggcatccgcg gggccgactt   3600

ccagtgcttc cagcaggcgc gggccgtggg gctggcgggc accttccgcg ccttcctgtc   3660

ctcgcgcctg caggacctgt acagcatcgt gcgccgtgcc gaccgcgcag ccgtgcccat   3720

cgtcaacctc aaggacgagc tgctgtttcc cagctgggag gctctgttct caggctctga   3780

gggtccgctg aagcccgggg cacgcatctt ctcctttgac ggcaaggacg tcctgaggca   3840

ccccacctgg ccccagaaga gcgtgtggca tggctcggac cccaacgggc gcaggctgac   3900

cgagagctac tgtgagacgt ggcggacgga ggctccctcg gccacgggcc aggcctcctc   3960

gctgctgggg ggcaggctcc tggggcagag tgccgcgagc tgccatcacg cctacatcgt   4020

gctctgcatt gagaacagct tcatgactgc ctccaagtag ccaccgcctg gatgcggatg   4080

gccggagagg accggcggct cggaggaagc ccccaccgtg ggcagggagc ggccggccag   4140

cccctggccc caggacctgg ctgccatact ttcctgtata gttcacgttt catgtaatcc   4200

tcaagaaata aaaggaagcc aaagagtgta tttttttaaa agtttaaaac agaagcctga   4260

tgctgacatt cacctgcccc aactctcccc tgacctgtga gcccagctgg gtcaggcagg   4320

gtgcagtatc atgccctgtg caacctcttg gcctgatcag accacggctc gatttctcca   4380

ggatttcctg ctttgggaag ccgtgctcgc cccagcaggt gctgacttca tctcccacct   4440

agcagcaccg ttctgtgcac aaaacccaga cctgttagca gacaggcccc gtgaggcaat   4500

gggagctgag gccacactca gcacaaggcc atctgggctc ctccagggtg tgtgctcgcc   4560

ctgcggtaga tgggagggag gctcaggtcc ctggggctag ggggagcccc ttctgctcag   4620

ctctgggcca ttctccacag caaccccagg ctgaagcagg ttcccaagct cagaggcgca   4680

ctgtgacccc cagctccggc ctgtcctcca acaccaagca cagcagcctg gggctggcct   4740

cccaaatgag ccatgagatg atacatccaa agcagacagc tccaccctgg ccgagtccaa   4800

gctgggagat tcaagggacc catgagttgg ggtctggcag cctcccatcc agggccccca   4860

tctcatgccc ctggctggga cgtggctcag ccagcacttg tccagctgag cgccaggatg   4920

gaacacggcc acatcaaaga ggctgaggct ggcacaggac atgcggtagc cagcacacag   4980

ggcagtgagg gagggctgtc atctgtgcac tgcccatgga caggctggct ccagatgcag   5040

ggcagtcatt ggctgtctcc taggaaaccc atatccttac cctccttggg actgaagggg   5100

aaccccgggg tgcccacagg ccgccctgcg ggtgaacaaa gcagccacga ggtgcaacaa   5160

ggtcctctgt cagtcacagc cacccctgag atccggcaac atcaacccga gtcattcgtt   5220

ctgtggaggg acaagtggac tcagggcagc gccaggctga ccacagcaca gccaacacgc   5280

acctgcctca ggactgcgac gaaaccggtg gggctggttc tgtaattgtg tgtgatgtga   5340

agccaattca gacaggcaaa taaaagtgac cttttacact gaaaaaaaaa aaaaaaaa     5398


<210>  1034
<211>  1336
<212>  PRT
<213>  Homosapiens

<400>  1034

Met Ala Pro Arg Cys Pro Trp Pro Trp Pro Arg Arg Arg Arg Leu Leu 
1               5                   10                  15      


Asp Val Leu Ala Pro Leu Val Leu Leu Leu Gly Val Arg Ala Ala Ser 
            20                  25                  30          


Ala Glu Pro Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu 
        35                  40                  45              


Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val 
    50                  55                  60                  


Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala 
65                  70                  75                  80  


Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe 
                85                  90                  95      


His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr 
            100                 105                 110         


Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val 
        115                 120                 125             


Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala 
    130                 135                 140                 


Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly 
145                 150                 155                 160 


Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu 
                165                 170                 175     


Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser 
            180                 185                 190         


Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala 
        195                 200                 205             


Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys 
    210                 215                 220                 


Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu 
225                 230                 235                 240 


Gly Asp Asp Ser Asp Gly Ala Phe Gly Asp Ser Gly Ser Gly Leu Gly 
                245                 250                 255     


Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro 
            260                 265                 270         


Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly 
        275                 280                 285             


Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr 
    290                 295                 300                 


Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser 
305                 310                 315                 320 


Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly 
                325                 330                 335     


Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly 
            340                 345                 350         


Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu 
        355                 360                 365             


Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr 
    370                 375                 380                 


Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr 
385                 390                 395                 400 


Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro 
                405                 410                 415     


Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 
            420                 425                 430         


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro 
        435                 440                 445             


Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu 
465                 470                 475                 480 


Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro 
                485                 490                 495     


Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser 
            500                 505                 510         


Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu 
        515                 520                 525             


Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
    530                 535                 540                 


Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu 
545                 550                 555                 560 


Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala 
                565                 570                 575     


Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro Gly Pro Ala Gly 
            580                 585                 590         


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Leu Pro 
        595                 600                 605             


Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro Phe Trp Ser Thr 
    610                 615                 620                 


Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly Leu Pro Gly Leu 
625                 630                 635                 640 


Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala Lys Gly Glu Val 
                645                 650                 655     


Gly Ala Asp Gly Ile Pro Gly Phe Pro Gly Leu Pro Gly Arg Glu Gly 
            660                 665                 670         


Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly Ser Arg Gly Glu 
        675                 680                 685             


Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly Leu Pro Gly 
    690                 695                 700                 


Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser Glu Gln Asp Gly 
705                 710                 715                 720 


Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro Gly Phe Ala Gly 
                725                 730                 735     


Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly Ser Lys Gly Glu 
            740                 745                 750         


Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu Pro Gly Ser Ile 
        755                 760                 765             


Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln Lys Gly Ala Lys 
    770                 775                 780                 


Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly 
785                 790                 795                 800 


Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg Pro Gly Met 
                805                 810                 815     


Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala Ser Leu Gly 
            820                 825                 830         


Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
        835                 840                 845             


Gly Pro Pro Gly Thr Pro Val Tyr Asp Ser Asn Val Phe Ala Glu Ser 
    850                 855                 860                 


Ser Arg Pro Gly Pro Pro Gly Leu Pro Gly Asn Gln Gly Pro Pro Gly 
865                 870                 875                 880 


Pro Lys Gly Ala Lys Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Gln 
                885                 890                 895     


Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met Lys Gly Glu Lys 
            900                 905                 910         


Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg Gly Glu Pro Gly 
        915                 920                 925             


Gly Gly Gly Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro 
    930                 935                 940                 


Gly Pro Arg Gly Tyr Pro Gly Ile Pro Gly Pro Lys Gly Glu Ser Ile 
945                 950                 955                 960 


Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Gly 
                965                 970                 975     


Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            980                 985                 990         


Pro Ser Phe Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
        995                 1000                 1005             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1010                 1015                 1020             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1025                 1030                 1035             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1040                 1045                 1050             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1055                 1060                 1065             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1070                 1075                 1080             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1085                 1090                 1095             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1100                 1105                 1110             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1115                 1120                 1125             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1130                 1135                 1140             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1145                 1150                 1155             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1160                 1165                 1170             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1175                 1180                 1185             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1190                 1195                 1200             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1205                 1210                 1215             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1220                 1225                 1230             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1235                 1240                 1245             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1250                 1255                 1260             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1265                 1270                 1275             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1280                 1285                 1290             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1295                 1300                 1305             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1310                 1315                 1320             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1325                 1330                 1335     


<210>  1035
<211>  2341
<212>  DNA
<213>  Homosapiens

<400>  1035
actgactggc ccccgagccc ggggcatctg agaaacctcc tgcgaatggc tacagaggaa     60

attttcaggt gcgagagatc tgaagaaagt tctggaaccc gcgcctggac cggtttggac    120

cctcagtgga aacacatcaa agagaaggaa aaccagctgg ggaaggatcc tggcagcggt    180

ggctcagggt gctgggcgga ggccccgttt ttcaccaacc gacggctggg agagcccgtg    240

ccacccactg tgccctgaga cccgcacagg acggcgactc acagatgcct tttgctgccc    300

tgcccgggtc ctggcacggc gcgaggtgcg tcaggccagg cagccacgca aaggccccgg    360

ctcctggctt ctgccatcta ttctgtcctg caactctatc ctggagcctc ccatcccttc    420

aaaagctgca ggaagaggcc tgcaggcaag agaagaggac tgcaggagtg agcaatttaa    480

gaaatggaag gccgaggttt tccaatctaa ttaacagcat gacaagccag gatgggctgc    540

tgacccgcgt ggagccttgc acagccagaa acgcggtgtc ctgctccgct cctgagacgc    600

cagggctgtc actgcaacac agcccccaac acttccacac gggcggactc tggctctcca    660

ggcaccgcag tgccctctcc ttcccttccc agctctcctg aggcctgtgg ttctgggagt    720

ctctgccccg tgcaagcgtg accgtggccc tcctcccatg tccagccgca ccaggccctg    780

ggatcccaga tctggcttca cctttgcaag gggctcaaag caagcaccta tgggggtggg    840

ggcggcaaag ccatctggcc aaggtccctt ctctagagtg cctgtctgtc cgtctgtcct    900

tgaggagcct gaggagtgca gggcaggaca ggcaggcacc agctgacccg gtaccgggca    960

gggaccagtg caggacctcg aggcagggct gggtggggtg ggggtggcca gagtctcctg   1020

gctcggagca gacacgggtg agtggcacag accgtcctca caccctcctg ggacagaggt   1080

aggaatccgt gaccaggaca gacacaggca ggactgggag aggcagagca ggtgcctgag   1140

cttggccacg cacagcttcc aatgaggttg ggccatccac agctccccaa ggttccccgc   1200

cactgttcac cccaccccag cacagccgag agctgtggtt tctcctccca tggagtcctg   1260

catggctgcc cactgcaggc ccagcccaag ggcaccgcct tctccaggct gccttccctg   1320

cacatgccac acctccagcc ccagaaggtt ctgaggaggg gaggagctgg ggcccccact   1380

cgccctcctg ttgccaggat acaggcccag gaaaaaatgc cacagtgctg gattaatgtc   1440

tagacaacgt gacctttccc ctggttctct agatataatt gggacccaaa ttgtccggtg   1500

tcatgagctg acagcaggga tgaaggaggg gtctgttctc ggtgccccga ggggactccg   1560

ggagagggag agggcagccc actacctgcg tgggggctgc agggggacga gccagggtcg   1620

cccacaaagg cgctttctgt ggaggggacg tcacctcttc catcagcgat gacgcagctc   1680

tgagatcaca gtgtcctcgc agtggctccc gttaactccc tgctgcccgt cctgccaggc   1740

tggtgccacg agaccctcgg ggctgggccg tgggacaggt gcctgcccag ccctgcaaac   1800

acatccagca ggtgtcgagg gctgccaagc acagacttct gctgccagcc atgcacagtg   1860

ccagctgcga cagcaacgcc tctgccagga gactcggagg agaccggccc tgacgctcct   1920

gtcgggggga gctgctgcac actcaggcag gatgcagggg tcctgagggg gaccctcggc   1980

tcacccacgg ctcccgtggc cggtctggtc ctggtattta tctcaacttc attgttgtcc   2040

agaagctgct ttttattatt tgtgaccgtg aaaggatgga aacaaattcc tgttttgagt   2100

caaagctacc tgcgtccacc gggccacaga gcggggacac ggccgtaatg tggagtcagt   2160

aagccaaggt tgtgagaaga ttctcaggag gggggtccag ggagggagaa ctgagggctg   2220

gggttccggg ggacatttta ctttttattc caggcagcgc tgtactggct ggggcctcaa   2280

atgctgaata atgctcctgt tggacttcag taattttaaa aaataaaact gtttaaaaat   2340

c                                                                   2341


<210>  1036
<211>  138
<212>  PRT
<213>  Homosapiens

<400>  1036

Met Pro Phe Ala Ala Leu Pro Gly Ser Trp His Gly Ala Arg Cys Val 
1               5                   10                  15      


Arg Pro Gly Ser His Ala Lys Ala Pro Ala Pro Gly Phe Cys His Leu 
            20                  25                  30          


Phe Cys Pro Ala Thr Leu Ser Trp Ser Leu Pro Ser Leu Gln Lys Leu 
        35                  40                  45              


Gln Glu Glu Ala Cys Arg Gln Glu Lys Arg Thr Ala Gly Val Ser Asn 
    50                  55                  60                  


Leu Arg Asn Gly Arg Pro Arg Phe Ser Asn Leu Ile Asn Ser Met Thr 
65                  70                  75                  80  


Ser Gln Asp Gly Leu Leu Thr Arg Val Glu Pro Cys Thr Ala Arg Asn 
                85                  90                  95      


Ala Val Ser Cys Ser Ala Pro Glu Thr Pro Gly Leu Ser Leu Gln His 
            100                 105                 110         


Ser Pro Gln His Phe His Thr Gly Gly Leu Trp Leu Ser Arg His Arg 
        115                 120                 125             


Ser Ala Leu Ser Phe Pro Ser Gln Leu Ser 
    130                 135             


<210>  1037
<211>  1286
<212>  DNA
<213>  Homosapiens

<400>  1037
ggcgccgcgg acgctgctgg agtcgcctgg caacgatgtc gcctggcaac tgaataggtt     60

ggccagtggc gcgggctact ggaagcagaa agggctgcgg aggcagtgag tggtttctgc    120

agagcttcat ttggaaaggc ctctgtagtt ggggaaagat ggcccattcc cagaactcct    180

tggagcttcc cattaacatc aatgccaccc agattaccac tgcctatggc catcgggccc    240

tgcccaagct gaaggaggag ctgcagtcag aggacctcca gacgaggcag aaagccctca    300

tggccttgtg tgacctcatg catgaccccg agtgtatcta caaggccatg aacataggct    360

gtatggagaa cctgaaagct ttgctgaagg atagcaacag tatggtgcgc ataaagacca    420

ccgaggtgct ccacatcacg gcaagccata gcgtgggcag atacgccttt ctagagcacg    480

acatcgtcct tgccctgtcc ttcctgctga atgaccccag cccagtctgc cgggggaacc    540

tgtacaaggc atacatgcag ctggtccagg tgcctagagg ggcccaagag atcatcagca    600

aaggtctgat ttcctcactg gtatggaagc tgcaggtgga ggtggaggag gaggagttcc    660

aggagttcat cctggacaca ctggtcctct gcctgcagga ggatgccacc gaggccctgg    720

gcagcaatgt ggtgcttgtc ctgaagcaga agctcctcag cgccaaccag aacatccgca    780

gcaaggccgc ccgtgcgctc cttaatgtca gcatatctcg agagggcaag aaacaggtgt    840

gtcattttga cgtcatcccc atcctggtcc atctgctgaa agacccagtg gagcatgtga    900

agtctaacgc tgccggtgcc ctgatgttcg ccacagtgat cactgaaggg aagtatgcgg    960

ccctggaggc acaagccatc ggcctgctcc tggagctgct gcactccccc atgaccatag   1020

cgcgcctgaa tgccaccaag gcccttacca tgctggcaga ggcccccgag ggccgcaagg   1080

ccctgcagac gcacgtgccc actttccgtg ccatggaggt ggagacttac gaaaagcctc   1140

aagtggccga agccttacag cgggcagccc ggatcgccat cagtgtcatc gagttcaaac   1200

cctgagccct tcattcacct ctgtgagtga ataaatgtgc taagtctctt taaaaaaaaa   1260

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1286


<210>  1038
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  1038

Met Ala His Ser Gln Asn Ser Leu Glu Leu Pro Ile Asn Ile Asn Ala 
1               5                   10                  15      


Thr Gln Ile Thr Thr Ala Tyr Gly His Arg Ala Leu Pro Lys Leu Lys 
            20                  25                  30          


Glu Glu Leu Gln Ser Glu Asp Leu Gln Thr Arg Gln Lys Ala Leu Met 
        35                  40                  45              


Ala Leu Cys Asp Leu Met His Asp Pro Glu Cys Ile Tyr Lys Ala Met 
    50                  55                  60                  


Asn Ile Gly Cys Met Glu Asn Leu Lys Ala Leu Leu Lys Asp Ser Asn 
65                  70                  75                  80  


Ser Met Val Arg Ile Lys Thr Thr Glu Val Leu His Ile Thr Ala Ser 
                85                  90                  95      


His Ser Val Gly Arg Tyr Ala Phe Leu Glu His Asp Ile Val Leu Ala 
            100                 105                 110         


Leu Ser Phe Leu Leu Asn Asp Pro Ser Pro Val Cys Arg Gly Asn Leu 
        115                 120                 125             


Tyr Lys Ala Tyr Met Gln Leu Val Gln Val Pro Arg Gly Ala Gln Glu 
    130                 135                 140                 


Ile Ile Ser Lys Gly Leu Ile Ser Ser Leu Val Trp Lys Leu Gln Val 
145                 150                 155                 160 


Glu Val Glu Glu Glu Glu Phe Gln Glu Phe Ile Leu Asp Thr Leu Val 
                165                 170                 175     


Leu Cys Leu Gln Glu Asp Ala Thr Glu Ala Leu Gly Ser Asn Val Val 
            180                 185                 190         


Leu Val Leu Lys Gln Lys Leu Leu Ser Ala Asn Gln Asn Ile Arg Ser 
        195                 200                 205             


Lys Ala Ala Arg Ala Leu Leu Asn Val Ser Ile Ser Arg Glu Gly Lys 
    210                 215                 220                 


Lys Gln Val Cys His Phe Asp Val Ile Pro Ile Leu Val His Leu Leu 
225                 230                 235                 240 


Lys Asp Pro Val Glu His Val Lys Ser Asn Ala Ala Gly Ala Leu Met 
                245                 250                 255     


Phe Ala Thr Val Ile Thr Glu Gly Lys Tyr Ala Ala Leu Glu Ala Gln 
            260                 265                 270         


Ala Ile Gly Leu Leu Leu Glu Leu Leu His Ser Pro Met Thr Ile Ala 
        275                 280                 285             


Arg Leu Asn Ala Thr Lys Ala Leu Thr Met Leu Ala Glu Ala Pro Glu 
    290                 295                 300                 


Gly Arg Lys Ala Leu Gln Thr His Val Pro Thr Phe Arg Ala Met Glu 
305                 310                 315                 320 


Val Glu Thr Tyr Glu Lys Pro Gln Val Ala Glu Ala Leu Gln Arg Ala 
                325                 330                 335     


Ala Arg Ile Ala Ile Ser Val Ile Glu Phe Lys Pro 
            340                 345             


<210>  1039
<211>  3225
<212>  DNA
<213>  Homosapiens

<400>  1039
gagggcgccg cggccccgtg ctcgccgccc cgccccgccc cgccctgccc ggagcagctc     60

ggcagatgct ctgtgctgcg gcccggaggt gaagggctgg atgcacagtg ggagccggag    120

gcggggggct gcagggagca caccagcgac cggccctcca accctccagc cactcagcaa    180

catcgccaca gcaaccagca accagacggc agcagccgag gcaaacacaa gcggacggct    240

tcccaccgtc gccgaggaca gggaatgact acggcaaatc aggccacttt gccaactagg    300

gaggtggagt gtcactagtg gggaggggcg gccaccgccc gctgcacaga gcgccatgcc    360

ggctggagaa gaggcgctgg ggcaggggct gcagtgtggc tcggcctcac ccccctgctg    420

gcactgagtg cctccagggc agctgggctc ttgtctgcct ggtctcagtg tcccctgtgg    480

caagagggag aggtgcccca tcccgtgctc cttgtctggg cccgctgctg ccagaccatg    540

ggatgtcggc aaagctcaga ggaaaaagaa gcagcccggc ggtcccggag aattgaccgc    600

cacctgcgct cagagagcca gcggcaacgc cgcgaaatca agctgctcct gctgggcacc    660

agcaactcag gcaagagcac catcgtcaaa cagatgaaga tcatccacag cggcggcttc    720

aacctggagg cctgcaagga gtacaagccc ctcatcatct acaatgccat cgactcgctg    780

acccgcatca tccgggccct ggccgccctc aggatcgact tccacaaccc cgaccgcgcc    840

tacgacgctg tgcagctctt tgcgctgacg ggccccgctg agagcaaggg cgagatcaca    900

cccgagctgc tgggtgtcat gcgacggctc tgggccgacc caggggcaca ggcctgcttc    960

agccgctcca gcgagtacca cctggaggac aacgcggcct actacctgaa cgacctggag   1020

cgcatcgccg cagctgacta tatccccact gtcgaggaca tcctgcgctc ccgggacatg   1080

accacgggca ttgtggagaa caagttcacc ttcaaggagc tcaccttcaa gatggtggac   1140

gtgggggggc agaggtcaga gcgcaaaaag tggatccact gcttcgaggg cgtcacagcc   1200

atcatcttct gtgtggagct cagcggctac gacctgaaac tctacgagga taaccagaca   1260

agtcggatgg cagagagctt gcgcctcttt gactccatct gcaacaacaa ctggttcatc   1320

aacacctcac tcatcctctt cctgaacaag aaggacctgc tggcagagaa gatccgccgc   1380

atcccgctca ccatctgctt tcccgagtac aagggccaga acacgtacga ggaggccgct   1440

gtctacatcc agcggcagtt tgaagacctg aaccgcaaca aggagaccaa ggagatctac   1500

tcccacttca cctgcgccac cgacaccagt aacatccagt ttgtcttcga cgcggtgaca   1560

gacgtcatca tacagaacaa tctcaagtac attggccttt gctgaggagc tgggcccggg   1620

gcccgcctgc ctatggtgaa acccacgggg tgtcatgccc caacgcgtgc tagagaggcc   1680

caatccaggg gcagaaaaca gggggcctaa agaatgtccc ccaccccttg gcctctgcct   1740

ccttggcccc acatttctgc aaacataaat atttacggat agattgctag gtagatagac   1800

acacacacat gcacacacac acatctggag atggcaaaat cctctaaaat gtcgaggtct   1860

cttgaagact tgagaagctg tcacaaggtc actacaagcc caacctgccc cttcactttg   1920

ccttcctgag ttggccccac tccacttggg ggtctgcatt ggattgttag ggataggcag   1980

cagggctgag gcaaggtagg ccaactgcac ccctgtcgcc tggaggaggg ccagctcgct   2040

gcccgagctc tggcctaggg accttgccgc tgaccaagag ggaggaccag tgcagggtct   2100

gtgcaccttc cctgctggcc tgcacacagc tgctcagcac cactttcatt ctggacctgg   2160

gaccttagga gccgggtgac agcactaacc agacctccag ccactcacag ctctttttaa   2220

aaaacagctt caaaatatgc agcaaaaacc aatacaacaa aacgagtggc acgatttatt   2280

tcaaactagg ccagctggga ttccagcttt tcttctacta gtctgatgtt ttataaatca   2340

aaacctggtt ttccttctct gacatttttt ttttgttttg ttttttggtt tttttttttt   2400

tttggccaaa tctcgtggtg tttcgcagaa aaaaatccag aaaatttcaa atgcagttga   2460

gtattctttt ttaaatgcag attttcaaaa catatttttt ttcaggtggt cttttttgtg   2520

tctggcttgc tgagtgtaaa agttgttatc tggacgatct gtctctctgc tccaaagaaa   2580

ttttggagtg agtggcagtc ctgcgccagc ctcgcgggac acgtgttgta cataagcctc   2640

tgcagtgtcc tcttgttaat ggtggggttt tctgctttgt ttttatttaa gaaaataaac   2700

acgacatatt taaagaaggt tctttcacct gggagcaaat gaacaatagc taagtgtctt   2760

ggtatttaaa gagtaaatta tttgtggctt tgctgagtga aggaagggga gcaaggggtg   2820

gtgcccctgg tcccagcatg ccccgcgcct gagactggct ggaaatgctc tgactcctgt   2880

gaaggcacag ccagcgttgt ggcctgaggg aggccctgct gggaccctga tctgggcctt   2940

cctgtcccag ggcctatggg caactgcgtt gaaaggacgt tcgccaaggg ccgtgtgtaa   3000

atacgaactg cgccatggag aggagaggca ctgccggagc ccttgccaga tctccctccc   3060

tctctccgtg cagtagctgt gtgtccgagg tcagtgtgcg gaatcacagc caaggacgtg   3120

aagagatgta cgggggaaag agaagctggg gattggatga aagtcaaagg ttgtctactt   3180

taagaaaata aaataccctg aatggagcac aaaaaaaaaa aaaaa                   3225


<210>  1040
<211>  355
<212>  PRT
<213>  Homosapiens

<400>  1040

Met Gly Cys Arg Gln Ser Ser Glu Glu Lys Glu Ala Ala Arg Arg Ser 
1               5                   10                  15      


Arg Arg Ile Asp Arg His Leu Arg Ser Glu Ser Gln Arg Gln Arg Arg 
            20                  25                  30          


Glu Ile Lys Leu Leu Leu Leu Gly Thr Ser Asn Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Ser Gly Gly Phe Asn Leu Glu 
    50                  55                  60                  


Ala Cys Lys Glu Tyr Lys Pro Leu Ile Ile Tyr Asn Ala Ile Asp Ser 
65                  70                  75                  80  


Leu Thr Arg Ile Ile Arg Ala Leu Ala Ala Leu Arg Ile Asp Phe His 
                85                  90                  95      


Asn Pro Asp Arg Ala Tyr Asp Ala Val Gln Leu Phe Ala Leu Thr Gly 
            100                 105                 110         


Pro Ala Glu Ser Lys Gly Glu Ile Thr Pro Glu Leu Leu Gly Val Met 
        115                 120                 125             


Arg Arg Leu Trp Ala Asp Pro Gly Ala Gln Ala Cys Phe Ser Arg Ser 
    130                 135                 140                 


Ser Glu Tyr His Leu Glu Asp Asn Ala Ala Tyr Tyr Leu Asn Asp Leu 
145                 150                 155                 160 


Glu Arg Ile Ala Ala Ala Asp Tyr Ile Pro Thr Val Glu Asp Ile Leu 
                165                 170                 175     


Arg Ser Arg Asp Met Thr Thr Gly Ile Val Glu Asn Lys Phe Thr Phe 
            180                 185                 190         


Lys Glu Leu Thr Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Glu Leu Ser Gly Tyr Asp Leu Lys Leu Tyr Glu Asp Asn Gln 
225                 230                 235                 240 


Thr Ser Arg Met Ala Glu Ser Leu Arg Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Asn Trp Phe Ile Asn Thr Ser Leu Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Leu Ala Glu Lys Ile Arg Arg Ile Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Lys Gly Gln Asn Thr Tyr Glu Glu Ala Ala Val Tyr Ile 
    290                 295                 300                 


Gln Arg Gln Phe Glu Asp Leu Asn Arg Asn Lys Glu Thr Lys Glu Ile 
305                 310                 315                 320 


Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Ser Asn Ile Gln Phe Val 
                325                 330                 335     


Phe Asp Ala Val Thr Asp Val Ile Ile Gln Asn Asn Leu Lys Tyr Ile 
            340                 345                 350         


Gly Leu Cys 
        355 


<210>  1041
<211>  3822
<212>  DNA
<213>  Homosapiens

<400>  1041
ctgccagccc cgcccagact ccaggcaggt tctcgttgct atggtgatcg ccggtgcaag     60

ctggatgctt ggacgcgccg ctgccagtcc aacgcagacc ccgcccacga cgtcgacgat    120

tcgtgtagcc cgcaggtccc gcgtggctct cgttgccatg gtgatcgccg ccgctggctc    180

aggcggacca ggccgcgcgg agccccagct ttcacagcca tcgctggact gtggaagaat    240

gaggtcctcc ctgacacctt tggggccccc tgtgagccgc gaccgtgtca tcgccagctt    300

ccctaagtgg tacacgccgg aagcctgttt gcagctcagg gagcacttcc acgggcaggt    360

cagcgctgcc tgccaacgca ggaacacggg gactgtcggg ctcaaactct ccaaggtggt    420

ggtggttggc gatctctacg tggggaagac cagcctcatc cacaggtttt gcaagaatgt    480

ttttgatcga gactacaagg ccaccattgg ggtggacttt gaaattgagc gctttgagat    540

tgctgggatt ccctatagcc tccagatctg ggacacagct gggcaggaga agttcaagtg    600

catcgcatct gcctactacc ggggtgccca ggtgatcatc acggcctttg acctcactga    660

cgtgcagacc ctggagcata ccaggcagtg gttggaggat gctctgaggg agaacgaggc    720

aggctcctgc ttcatcttcc tcgtgggaac caagaaggac cttctgtcag gggccgcatg    780

tgagcaggcc gaagcagacg ctgtgcacct ggccagggag atgcaggccg agtactggtc    840

agtgtcggcc aagactggcg agaacgtgaa ggcattcttc agccgcgtag ccgccctggc    900

attcgagcag tcggtgctgc aggacctgga gaggcagagc agtgcccggc tccaggtcgg    960

caatggagac ctaatccaaa tggaagggag tccgcccgag acccaggaga gcaagaggcc   1020

ctccagcctg ggctgctgct aactggggcc tgcgtggaag gcctccgctc cctgcacaca   1080

cacggacagg aatttccgtg actgtggtgt ggagactgga gcccaagctc tgcagcgtgt   1140

cgccctcaag ctgtaggccc atgttccagt ccctccaccc acccaccggg ctcagctcca   1200

gggcacagtc acttgtccgt tgcaggttgg gcactagaaa aggcccccac tggctgcctg   1260

ggagccccac accaccgggc cagtgcaggc actgtggtga tcccataaaa ggccagtcca   1320

tttgcagggt catcagacag tcacctttgg cctcaagagg cctcagaact gcaaactcct   1380

gcgtcggtct atactactcg gccatggccc acatcagcag tcaaccctgc actctttccc   1440

agcgatcttg gatgtgtccc caggatccgt cacagtgttc caggcaacct ggacttgtca   1500

aagtcagcac ctgaaggaga ggccacctgc cattccccct gggagttttc tgttgtcagc   1560

aggacttatg gttctgggtc tcagagcttc aggcctcact gtccttctgc cacggatgct   1620

caaggttcct gggcagacca gcacctctgg aggacaatgg acaaaatgtc tcttagacct   1680

gttctggctg aagggctatc tctggcacct ctgagatccc taggtcctgc cctcctggtc   1740

cgtgggccag gatgtgcaga acaaccactc aggcctttct ggcccacctg gacagtgcat   1800

ttacctgtgt gctgcgggag gcagactgca cagctgtcct agggtaactc actctgcagc   1860

ccttgaacat ggcactgccc tcctctggca ctcatgctgg gcctgtgccc actgctgcct   1920

ctccatccct ctctcattgg cctatacatc tcttaggacc tttgtaatgg tgtccatgca   1980

cctttagagg acttcagagg ccctgccaag tctagcatgt tcctgtctcc aacaccgcct   2040

cctgcacatg cagagcagac agaaataccc cacacattcc ccagcctctc tgcccagtat   2100

gctcatccac agggttttct cactgctatg aaccagcccc acagccccag gcccctgtca   2160

cctggctatg cccactcatc ccacccgtct cgtgctgttg cttcccgtag atggcgagca   2220

ccttgcaggc agccttctga tcagtactgc tctcctaggg cctggcacac tgcagctgcc   2280

ctgtaaatgt tcagctcagc gattgccaaa taccagttag ggaagaacac tggcatcttt   2340

ttctattcat tcccccttca acatattttt tgtagttttt tatataaatg actttttttt   2400

ttttttgaga tggagtttca cccttgttgc ccaggctgga gtgcaatggc gtaatctcgg   2460

ctcagtgcaa cctctgcctc ccaggttgaa gcgattctcc tgcctcagcc tcccaagtag   2520

ctgggattac aggcatgcac caccatgcct ggctaatttt gtatttttag tagagatggg   2580

gtttctccat gttggtcagg ctgctctcgg actcctgatc tcaggtgacc tgcccacctc   2640

ggcctcccga agtgctggga ttacaagggt gagccaccat gcccggccat aaatgatttt   2700

attcattttt atgttttctt ttgggcggcg ggatggagtc tctgtcaccc aggctggcgt   2760

gcaatggcac gatcttggct cactgcaagc ttccccttcc gggttcatgc cattctcctg   2820

cctcagcctc ccgagtagct gggactacag gcacgtgtga ccatgccggg ctaatttttt   2880

atatttttag tagagagagg tttcaccgtg ttagccagga tggtctcgat gatctgacct   2940

cgtgatctgc ccgcctcggc ctcccaaagt gctgggatta caggcctgag ccaccgcgtc   3000

cggcctccat aaatgacttt taaaggggtt gtatgtttag tgtgaacaaa gacagtacaa   3060

agcatataaa atacaaggtg aaagcccccc ccccgccaca ttagctgcgc ccctgaagtg   3120

tctccagcag aagagatgga tgaatggaag gacacacaga tggacagaga gcaggaaaga   3180

ctgttagctc tgctaacagt caggactatt ccttctggac tctgtgcctt tgcctgcaca   3240

gctagtgttg atggcttgtt tgttgttttc accagagtga gctccttctg gacatactgc   3300

ctggcagcct gccttcctag ggagctggcg ccaaggcctc tccctgatgg cacacaagga   3360

gcctccttcc tgtagcagcg cccagttttc atgtggatgg attgtagttc atttgaccct   3420

ccccatccgc gggccatccg gcttgtgtcc agcttttagc tcttgccaat ggtgctgcag   3480

tggccattct tgtagttata gctttgcgta ctcaggaagg cccttctccc gactgcggcc   3540

cccagcctgg tccactaaat gcagcctgtg gtcgggcaga cagcattggg gtccattagg   3600

aagaccaggt ttgctgggca taagcttcac aggacgggag aacctgccca tggtggactg   3660

tcgttctcca cagctccctt cccttgcccc ttcgggcctc caggatatgt ttgcgggggt   3720

gggtgtggtg tccagctgtt accagcttct gagctagagc tgtactgcct cacgtacacc   3780

cccacctctg taaatggtcc ttgattaaat cgtcctcata tt                      3822


<210>  1042
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  1042

Met Val Ile Ala Gly Ala Ser Trp Met Leu Gly Arg Ala Ala Ala Ser 
1               5                   10                  15      


Pro Thr Gln Thr Pro Pro Thr Thr Ser Thr Ile Arg Val Ala Arg Arg 
            20                  25                  30          


Ser Arg Val Ala Leu Val Ala Met Val Ile Ala Ala Ala Gly Ser Gly 
        35                  40                  45              


Gly Pro Gly Arg Ala Glu Pro Gln Leu Ser Gln Pro Ser Leu Asp Cys 
    50                  55                  60                  


Gly Arg Met Arg Ser Ser Leu Thr Pro Leu Gly Pro Pro Val Ser Arg 
65                  70                  75                  80  


Asp Arg Val Ile Ala Ser Phe Pro Lys Trp Tyr Thr Pro Glu Ala Cys 
                85                  90                  95      


Leu Gln Leu Arg Glu His Phe His Gly Gln Val Ser Ala Ala Cys Gln 
            100                 105                 110         


Arg Arg Asn Thr Gly Thr Val Gly Leu Lys Leu Ser Lys Val Val Val 
        115                 120                 125             


Val Gly Asp Leu Tyr Val Gly Lys Thr Ser Leu Ile His Arg Phe Cys 
    130                 135                 140                 


Lys Asn Val Phe Asp Arg Asp Tyr Lys Ala Thr Ile Gly Val Asp Phe 
145                 150                 155                 160 


Glu Ile Glu Arg Phe Glu Ile Ala Gly Ile Pro Tyr Ser Leu Gln Ile 
                165                 170                 175     


Trp Asp Thr Ala Gly Gln Glu Lys Phe Lys Cys Ile Ala Ser Ala Tyr 
            180                 185                 190         


Tyr Arg Gly Ala Gln Val Ile Ile Thr Ala Phe Asp Leu Thr Asp Val 
        195                 200                 205             


Gln Thr Leu Glu His Thr Arg Gln Trp Leu Glu Asp Ala Leu Arg Glu 
    210                 215                 220                 


Asn Glu Ala Gly Ser Cys Phe Ile Phe Leu Val Gly Thr Lys Lys Asp 
225                 230                 235                 240 


Leu Leu Ser Gly Ala Ala Cys Glu Gln Ala Glu Ala Asp Ala Val His 
                245                 250                 255     


Leu Ala Arg Glu Met Gln Ala Glu Tyr Trp Ser Val Ser Ala Lys Thr 
            260                 265                 270         


Gly Glu Asn Val Lys Ala Phe Phe Ser Arg Val Ala Ala Leu Ala Phe 
        275                 280                 285             


Glu Gln Ser Val Leu Gln Asp Leu Glu Arg Gln Ser Ser Ala Arg Leu 
    290                 295                 300                 


Gln Val Gly Asn Gly Asp Leu Ile Gln Met Glu Gly Ser Pro Pro Glu 
305                 310                 315                 320 


Thr Gln Glu Ser Lys Arg Pro Ser Ser Leu Gly Cys Cys 
                325                 330             


<210>  1043
<211>  4739
<212>  DNA
<213>  Homosapiens

<400>  1043
ggggagatag gtaggagtag cgtggtaagg gcgatgagtg tgggccgggc gggagtgcgg     60

cgagagccgg ctggctgagc ttagcgtccg aggaggcggc ggcggcggcg gcggcagcgg    120

cggcggcggg gctgtggggc ggtgcggaag cgagaggcga ggagcgcgcg ggccgtggcc    180

agagtctggc ggcggcctgg cggagcggag agcagcgccc gcgcctcgcc gtgcggagga    240

gccccgcaca caatagcggc gcgcgcagcc cgcgcccttc cccccggcgc gccccgcccc    300

gcgcgccgag cgccccgctc cgcctcacct gccaccaggg agtgggcggg cattgttcgc    360

cgccgccgcc gccgcgcggg gccatggggg ccgcccggcg cccggggccg ggcctggcga    420

ggccgccgcg ccgccgctga gacgggcccc gcgcgcagcc cggcggcgca ggtaaggccg    480

gccgcgccat ggtggacccg gtgggcttcg cggaggcgtg gaaggcgcag ttcccggact    540

cagagccccc gcgcatggag ctgcgctcag tgggcgacat cgagcaggag ctggagcgct    600

gcaaggcctc cattcggcgc ctggagcagg aggtgaacca ggagcgcttc cgcatgatct    660

acctgcagac gttgctggcc aaggaaaaga agagctatga ccggcagcga tggggcttcc    720

ggcgcgcggc gcaggccccc gacggcgcct ccgagccccg agcgtccgcg tcgcgcccgc    780

agccagcgcc cgccgacgga gccgacccgc cgcccgccga ggagcccgag gcccggcccg    840

acggcgaggg ttctccgggt aaggccaggc ccgggaccgc ccgcaggccc ggggcagccg    900

cgtcggggga acgggacgac cggggacccc ccgccagcgt ggcggcgctc aggtccaact    960

tcgagcggat ccgcaagggc catggccagc ccggggcgga cgccgagaag cccttctacg   1020

tgaacgtcga gtttcaccac gagcgcggcc tggtgaaggt caacgacaaa gaggtgtcgg   1080

accgcatcag ctccctgggc agccaggcca tgcagatgga gcgcaaaaag tcccagcacg   1140

gcgcgggctc gagcgtgggg gatgcatcca ggccccctta ccggggacgc tcctcggaga   1200

gcagctgcgg cgtcgacggc gactacgagg acgccgagtt gaacccccgc ttcctgaagg   1260

acaacctgat cgacgccaat ggcggtagca ggcccccttg gccgcccctg gagtaccagc   1320

cctaccagag catctacgtc gggggcatga tggaagggga gggcaagggc ccgctcctgc   1380

gcagccagag cacctctgag caggagaagc gccttacctg gccccgcagg tcctactccc   1440

cccggagttt tgaggattgc ggaggcggct ataccccgga ctgcagctcc aatgagaacc   1500

tcacctccag cgaggaggac ttctcctctg gccagtccag ccgcgtgtcc ccaagcccca   1560

ccacctaccg catgttccgg gacaaaagcc gctctccctc gcagaactcg caacagtcct   1620

tcgacagcag cagtcccccc acgccgcagt gccataagcg gcaccggcac tgcccggttg   1680

tcgtgtccga ggccaccatc gtgggcgtcc gcaagaccgg gcagatctgg cccaacgatg   1740

gcgagggcgc cttccatgga gacgcagatg gctcgttcgg aacaccacct ggatacggct   1800

gcgctgcaga ccgggcagag gagcagcgcc ggcaccaaga tgggctgccc tacattgatg   1860

actcgccctc ctcatcgccc cacctcagca gcaagggcag gggcagccgg gatgcgctgg   1920

tctcgggagc cctggagtcc actaaagcga gtgagctgga cttggaaaag ggcttggaga   1980

tgagaaaatg ggtcctgtcg ggaatcctgg ctagcgagga gacttacctg agccacctgg   2040

aggcactgct gctgcccatg aagcctttga aagccgctgc caccacctct cagccggtgc   2100

tgacgagtca gcagatcgag accatcttct tcaaagtgcc tgagctctac gagatccaca   2160

aggagttcta tgatgggctc ttcccccgcg tgcagcagtg gagccaccag cagcgggtgg   2220

gcgacctctt ccagaagctg gccagccagc tgggtgtgta ccgggccttc gtggacaact   2280

acggagttgc catggaaatg gctgagaagt gctgtcaggc caatgctcag tttgcagaaa   2340

tctccgagaa cctgagagcc agaagcaaca aagatgccaa ggatccaacg accaagaact   2400

ctctggaaac tctgctctac aagcctgtgg accgtgtgac gaggagcacg ctggtcctcc   2460

atgacttgct gaagcacact cctgccagcc accctgacca ccccttgctg caggacgccc   2520

tccgcatctc acagaacttc ctgtccagca tcaatgagga gatcacaccc cgacggcagt   2580

ccatgacggt gaagaaggga gagcaccggc agctgctgaa ggacagcttc atggtggagc   2640

tggtggaggg ggcccgcaag ctgcgccacg tcttcctgtt caccgagctg cttctctgca   2700

ccaagctcaa gaagcagagc ggaggcaaaa cgcagcagta tgactgcaaa tggtacattc   2760

cgctcacgga tctcagcttc cagatggtgg atgaactgga ggcagtgccc aacatccccc   2820

tggtgcccga tgaggagctg gacgctttga agatcaagat ctcccagatc aagagtgaca   2880

tccagagaga gaagagggcg aacaagggca gcaaggctac ggagaggctg aagaagaagc   2940

tgtcggagca ggagtcactg ctgctgctta tgtctcccag catggccttc agggtgcaca   3000

gccgcaacgg caagagttac acgttcctga tctcctctga ctatgagcgt gcagagtgga   3060

gggagaacat ccgggagcag cagaagaagt gtttcagaag cttctccctg acatccgtgg   3120

agctgcagat gctgaccaac tcgtgtgtga aactccagac tgtccacagc attccgctga   3180

ccatcaataa ggaagatgat gagtctccgg ggctctatgg gtttctgaat gtcatcgtcc   3240

actcagccac tggatttaag cagagttcaa atctgtactg caccctggag gtggattcct   3300

ttgggtattt tgtgaataaa gcaaagacgc gcgtctacag ggacacagct gagccaaact   3360

ggaacgagga atttgagata gagctggagg gctcccagac cctgaggata ctgtgctatg   3420

aaaagtgtta caacaagacg aagatcccca aggaggacgg cgagagcacg gacagactca   3480

tggggaaggg ccaggtccag ctggacccgc aggccctgca ggacagagac tggcagcgca   3540

ccgtcatcgc catgaatggg atcgaagtaa agctctcggt caagttcaac agcagggagt   3600

tcagcttgaa gaggatgccg tcccgaaaac agacaggggt cttcggagtc aagattgctg   3660

tggtcaccaa gagagagagg tccaaggtgc cctacatcgt gcgccagtgc gtggaggaga   3720

tcgagcgccg aggcatggag gaggtgggca tctaccgcgt gtccggtgtg gccacggaca   3780

tccaggcact gaaggcagcc ttcgacgtca ataacaagga tgtgtcggtg atgatgagcg   3840

agatggacgt gaacgccatc gcaggcacgc tgaagctgta cttccgtgag ctgcccgagc   3900

ccctcttcac tgacgagttc taccccaact tcgcagaggg catcgctctt tcagacccgg   3960

ttgcaaagga gagctgcatg ctcaacctgc tgctgtccct gccggaggcc aacctgctca   4020

ccttcctttt ccttctggac cacctgaaaa gggtggcaga gaaggaggca gtcaataaga   4080

tgtccctgca caacctcgcc acggtctttg gccccacgct gctccggccc tccgagaagg   4140

agagcaagct ccctgccaac cccagccagc ctatcaccat gactgacagc tggtccttgg   4200

aggtcatgtc ccaggtccag gtgctgctgt acttcctgca gctggaggcc atccctgccc   4260

cggacagcaa gagacagagc atcctgttct ccaccgaagt ctaaaggtcc cagtccatct   4320

cctggaggca gacagatggc ctggaaacct ctggctaatc gggccatccg tagagcggga   4380

accttcctga ggtgtccttg ggccaccccc aagtgttggg ccatctgcca agagacagcg   4440

acccaaagcc gaaggacagg tggcctgggc agatctcgcc caggtctggg agccccaggc   4500

tggcctcaga ctgtggtttt ttatgtggcc acccgagggc gccccaagcc agttcatctc   4560

agagtccagg cctgaccctg ggagacaggg tgaagggagt gatttttatg aacttaactt   4620

agagtctaaa agatttctac tggatcactt gtcaagatgc gccctctctg gggagaaggg   4680

aacgtgaccg gattccctca ctgttgtatc ttgaataaac gctgctgctt catcctgtg    4739


<210>  1044
<211>  1271
<212>  PRT
<213>  Homosapiens

<400>  1044

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Glu Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Asn 
        915                 920                 925             


Leu Tyr Cys Thr Leu Glu Val Asp Ser Phe Gly Tyr Phe Val Asn Lys 
    930                 935                 940                 


Ala Lys Thr Arg Val Tyr Arg Asp Thr Ala Glu Pro Asn Trp Asn Glu 
945                 950                 955                 960 


Glu Phe Glu Ile Glu Leu Glu Gly Ser Gln Thr Leu Arg Ile Leu Cys 
                965                 970                 975     


Tyr Glu Lys Cys Tyr Asn Lys Thr Lys Ile Pro Lys Glu Asp Gly Glu 
            980                 985                 990         


Ser Thr Asp Arg Leu Met Gly Lys  Gly Gln Val Gln Leu  Asp Pro Gln 
        995                 1000                 1005             


Ala Leu  Gln Asp Arg Asp Trp  Gln Arg Thr Val Ile  Ala Met Asn 
    1010                 1015                 1020             


Gly Ile  Glu Val Lys Leu Ser  Val Lys Phe Asn Ser  Arg Glu Phe 
    1025                 1030                 1035             


Ser Leu  Lys Arg Met Pro Ser  Arg Lys Gln Thr Gly  Val Phe Gly 
    1040                 1045                 1050             


Val Lys  Ile Ala Val Val Thr  Lys Arg Glu Arg Ser  Lys Val Pro 
    1055                 1060                 1065             


Tyr Ile  Val Arg Gln Cys Val  Glu Glu Ile Glu Arg  Arg Gly Met 
    1070                 1075                 1080             


Glu Glu  Val Gly Ile Tyr Arg  Val Ser Gly Val Ala  Thr Asp Ile 
    1085                 1090                 1095             


Gln Ala  Leu Lys Ala Ala Phe  Asp Val Asn Asn Lys  Asp Val Ser 
    1100                 1105                 1110             


Val Met  Met Ser Glu Met Asp  Val Asn Ala Ile Ala  Gly Thr Leu 
    1115                 1120                 1125             


Lys Leu  Tyr Phe Arg Glu Leu  Pro Glu Pro Leu Phe  Thr Asp Glu 
    1130                 1135                 1140             


Phe Tyr  Pro Asn Phe Ala Glu  Gly Ile Ala Leu Ser  Asp Pro Val 
    1145                 1150                 1155             


Ala Lys  Glu Ser Cys Met Leu  Asn Leu Leu Leu Ser  Leu Pro Glu 
    1160                 1165                 1170             


Ala Asn  Leu Leu Thr Phe Leu  Phe Leu Leu Asp His  Leu Lys Arg 
    1175                 1180                 1185             


Val Ala  Glu Lys Glu Ala Val  Asn Lys Met Ser Leu  His Asn Leu 
    1190                 1195                 1200             


Ala Thr  Val Phe Gly Pro Thr  Leu Leu Arg Pro Ser  Glu Lys Glu 
    1205                 1210                 1215             


Ser Lys  Leu Pro Ala Asn Pro  Ser Gln Pro Ile Thr  Met Thr Asp 
    1220                 1225                 1230             


Ser Trp  Ser Leu Glu Val Met  Ser Gln Val Gln Val  Leu Leu Tyr 
    1235                 1240                 1245             


Phe Leu  Gln Leu Glu Ala Ile  Pro Ala Pro Asp Ser  Lys Arg Gln 
    1250                 1255                 1260             


Ser Ile  Leu Phe Ser Thr Glu  Val 
    1265                 1270     


<210>  1045
<211>  4714
<212>  DNA
<213>  Homosapiens

<400>  1045
ggggggaggg tggcggctcg atgggggagc cgccccaggg ggcccccccg ccctgtgccc     60

acggcgcggc ccctttaagg aggcccgcct ggctccgctc catcgcgcat cgcggccgcc    120

tccccccggc cctcccttcc tgcggcgcag agtgcgggcc gggcgggagt gcggcgagcc    180

ggctggctta gcgtccgagg aggcggcggc ggcggcggcg gcagcggcgg cggcggggct    240

ggtggggcgg tgcggaagcg agaggcgagg agcgcgcggg ccgtggccag agtctggcgg    300

cggcctggcg gagcggagag cagcgcccgc gcctcgccgt gcggaggagc cccgcacaca    360

atagcggcgc gcgcagcccg cgcccttccc cccggcgcgc cccgccccgc gcgccgagcg    420

ccccgctccg cctcacctgc caccagggag tgggcgggca ttgttcgccg ccgccgccgc    480

cgcgcggggc catgggggcc gcccggcgcc cggggccggg cctggcgagg ccgccgcgcc    540

gccgctgaga cgggccccgc gcgcagcccg gcggcgcagg taaggccggc cgcgccatgg    600

tggacccggt gggcttcgcg gaggcgtgga aggcgcagtt cccggactca gagcccccgc    660

gcatggagct gcgctcagtg ggcgacatcg agcaggagct ggagcgctgc aaggcctcca    720

ttcggcgcct ggagcaggag gtgaaccagg agcgcttccg catgatctac ctgcagacgt    780

tgctggccaa ggaaaagaag agctatgacc ggcagcgatg gggcttccgg cgcgcggcgc    840

aggcccccga cggcgcctcc gagccccgag cgtccgcgtc gcgcccgcag ccagcgcccg    900

ccgacggagc cgacccgccg cccgccgagg agcccgaggc ccggcccgac ggcgagggtt    960

ctccgggtaa ggccaggccc gggaccgccc gcaggcccgg ggcagccgcg tcgggggaac   1020

gggacgaccg gggacccccc gccagcgtgg cggcgctcag gtccaacttc gagcggatcc   1080

ggaagggcca tggccagccc ggggcggacg ccgagaagcc cttctacgtg aacgtcgagt   1140

ttcaccacga gcgcggcctg gtgaaggtca acgacaaaga ggtgtcggac cgcatcagct   1200

cccttggcag ccaggccatg cagatggagc gcaaaaagtc ccagcacggc gcgggctcga   1260

gcgtggggga tgcatccagg cccccttacc ggggacgctc ctcggagagc agctgcggcg   1320

tcgacggcga ctacgaggac gccgagttga acccccgctt cctgaaggac aacctgatcg   1380

acgccaatgg cggtagcagg cccccttggc cgcccctgga gtaccagccc taccagagca   1440

tctacgtcgg gggcatcatg gaaggggagg gcaagggccc gctcctgcgc agccagagca   1500

cctctgagca ggagaagcgc cttacctggc cccgcaggtc ctactccccc cggagttttg   1560

aggattgcgg aggcggctat accccggact gcagctccaa tgagaacctc acctccagcg   1620

aggaggactt ctcctctggc cagtccagcc gcgtgtcccc aagccccacc acctaccgca   1680

tgttccggga caaaagccgc tctccctcgc agaactcgca acagtccttc gacagcagca   1740

gtccccccac gccgcagtgc cataagcggc accggcactg cccggttgtc gtgtccgagg   1800

ccaccatcgt gggcgtccgc aagaccgggc agatctggcc caacgatgac gagggcgcct   1860

tccatggaga cgcagatggc tcgttcggaa caccacctgg atacggctgc gctgcagacc   1920

gggcagagga gcagcgccgg caccaagatg ggctgcccta cattgatgac tcgccctcct   1980

catcgcccca cctcagcagc aagggcaggg gcagccggga tgcgctggtc tcgggagccc   2040

tgaagtccac taaagcgagt gagctggact tggaaaaggg cttggagatg agaaaatggg   2100

tcctgtcggg aatcctggct agcgaggaga cttacctgag ccacctggag gcactgctgc   2160

tgcccatgaa gcctttgaaa gccgctgcca ccacctctca gccggtgctg acgagtcagc   2220

agatcgagac catcttcttc aaagtgcctg agctctacga gatccacaag gagtcctatg   2280

atgggctctt cccccgcgtg cagcagtgga gccaccagca gcgggtgggc gacctcttcc   2340

agaagctggc cagccagctg ggtgtgtacc gggccttcgt ggacaactac ggagttgcca   2400

tggaaatggc tgagaagtgc tgtcaggcca atgctcagtt tgcagaaatc tccgagaacc   2460

tgagagccag aagcaacaaa gatgccaagg atccaacgac caagaactct ctggaaactc   2520

tgctctacaa gcctgtggac cgtgtgacga ggagcacgct ggtcctccat gacttgctga   2580

agcacactcc tgccagccac cctgaccacc ccttgctgca ggacgccctc cgcatctcac   2640

agaacttcct gtccagcatc aatgaggaga tcacaccccg acggcagtcc atgacggtga   2700

agaagggaga gcaccggcag ctgctgaagg acagcttcat ggtggagctg gtggaggggg   2760

cccgcaagct gcggcacgtc ttcctgttca ccgacctgct tctctgcacc aagctcaaga   2820

agcagagcgg aggcaaaacg cagcagtatg actgcaaatg gtacattccg ctcacggatc   2880

tcagcttcca gatggtggat gaactggagg cagtgcccaa catccccctg gtgcccgatg   2940

aggagctgga cgctttgaag atcaagatct cccagatcaa gagtgacatc cagagagaga   3000

agagggcgaa caagggcagc aaggctacgg agaggctgaa gaagaagctg tcggagcagg   3060

agtcactgct gctgcttatg tctcccagca tggccttcag ggtgcacagc cgcaacggca   3120

agagttacac gttcctgatc tcctctgact atgagcgtgc agagtggagg gagaacatcc   3180

gggagcagca gaagaagtgt ttcagaagct tctccctgac atccgtggag ctgcagatgc   3240

tgaccaactc gtgtgtgaaa ctccagactg tccacagcat tccgctgacc atcaataagg   3300

aagatgatga gtctccgggg ctctatgggt ttctgaatgt catcgtccac tcagccactg   3360

gatttaagca gagttcaaat ctgtactgca ccctggaggt ggattccttt gggtattttg   3420

tgaataaagc aaagacgcgc gtctacaggg acacagctga gccaaactgg aacgagctgg   3480

acccgcaggc cctgcaggac agagactggc agcgcaccgt catcgccatg aatgggatcg   3540

aagtaaagct ctcggtcaag ttcaacagca gggagttcag cttgaagagg atgccgtccc   3600

gaaaacagac aggggtcttc ggagtcaaga ttgctgtggt caccaagaga gagaggtcca   3660

aggtgcccta catcgtgcgc cagtgcgtgg aggagatcga gcgccgaggc atggaggagg   3720

tgggcatcta ccgcgtgtcc ggtgtggcca cggacatcca ggcactgaag gcagccttcg   3780

acgtcaataa caaggatgtg tcggtgatga tgagcgagat ggacgtgaac gccatcgcag   3840

gcacgctgaa gctgtacttc cgtgagctgc ccgagcccct cttcactgac gagttctacc   3900

ccaacttcgc agagggcatc gctctttcag acccggttgc aaaggagagc tgcatgctca   3960

acctgctgct gtccctgccg gaggccaacc tgctcacctt ccttttcctt ctggaccacc   4020

tgaaaagggt ggcagagaag gaggcagtca ataagatgtc cctgcacaac ctcgccacgg   4080

tctttggccc cacgctgctc cggccctccg agaaggagag caagctccct gccaacccca   4140

gccagcctat caccatgact gacagctggt ccttggaggt catgtcccag gtccaggtgc   4200

tgctgtactt cctgcagctg gaggccatcc ctgccccgga cagcaagaga cagagcatcc   4260

tgttctccac cgaagtctaa aggtcccagt ccatctcctg gaggcagaca gatggcctgg   4320

aaacctctgg ctaatcgggc catccgtaga gcgggaacct tcctgaggtg tccttgggcc   4380

acccccaagt gttgggccat ctgccaagag acagcgaccc aaagccgaag gacaggtggc   4440

ctgggcagat ctgcccaggt ctgggagccc caagctggcc tcagactgtg gttttttatg   4500

tggccacccg agggcgcccc aagccagttc atctcggagt ccaggcctga ccctgggaga   4560

cagggtgaag ggagtgattt ttatgaactt aacttagagt ctaaaagatt tctactggat   4620

cacttgtcaa gatgcgccct ctctggggag aagggaacgt gaccggattc cctcactgtt   4680

gtatcttgaa taaacgctgc tgcttcaaaa aaaa                               4714


<210>  1046
<211>  1227
<212>  PRT
<213>  Homosapiens

<400>  1046

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Ile Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Asp Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Lys Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Ser 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Ser Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Asn 
        915                 920                 925             


Leu Tyr Cys Thr Leu Glu Val Asp Ser Phe Gly Tyr Phe Val Asn Lys 
    930                 935                 940                 


Ala Lys Thr Arg Val Tyr Arg Asp Thr Ala Glu Pro Asn Trp Asn Glu 
945                 950                 955                 960 


Leu Asp Pro Gln Ala Leu Gln Asp Arg Asp Trp Gln Arg Thr Val Ile 
                965                 970                 975     


Ala Met Asn Gly Ile Glu Val Lys Leu Ser Val Lys Phe Asn Ser Arg 
            980                 985                 990         


Glu Phe Ser Leu Lys Arg Met Pro  Ser Arg Lys Gln Thr  Gly Val Phe 
        995                 1000                 1005             


Gly Val  Lys Ile Ala Val Val  Thr Lys Arg Glu Arg  Ser Lys Val 
    1010                 1015                 1020             


Pro Tyr  Ile Val Arg Gln Cys  Val Glu Glu Ile Glu  Arg Arg Gly 
    1025                 1030                 1035             


Met Glu  Glu Val Gly Ile Tyr  Arg Val Ser Gly Val  Ala Thr Asp 
    1040                 1045                 1050             


Ile Gln  Ala Leu Lys Ala Ala  Phe Asp Val Asn Asn  Lys Asp Val 
    1055                 1060                 1065             


Ser Val  Met Met Ser Glu Met  Asp Val Asn Ala Ile  Ala Gly Thr 
    1070                 1075                 1080             


Leu Lys  Leu Tyr Phe Arg Glu  Leu Pro Glu Pro Leu  Phe Thr Asp 
    1085                 1090                 1095             


Glu Phe  Tyr Pro Asn Phe Ala  Glu Gly Ile Ala Leu  Ser Asp Pro 
    1100                 1105                 1110             


Val Ala  Lys Glu Ser Cys Met  Leu Asn Leu Leu Leu  Ser Leu Pro 
    1115                 1120                 1125             


Glu Ala  Asn Leu Leu Thr Phe  Leu Phe Leu Leu Asp  His Leu Lys 
    1130                 1135                 1140             


Arg Val  Ala Glu Lys Glu Ala  Val Asn Lys Met Ser  Leu His Asn 
    1145                 1150                 1155             


Leu Ala  Thr Val Phe Gly Pro  Thr Leu Leu Arg Pro  Ser Glu Lys 
    1160                 1165                 1170             


Glu Ser  Lys Leu Pro Ala Asn  Pro Ser Gln Pro Ile  Thr Met Thr 
    1175                 1180                 1185             


Asp Ser  Trp Ser Leu Glu Val  Met Ser Gln Val Gln  Val Leu Leu 
    1190                 1195                 1200             


Tyr Phe  Leu Gln Leu Glu Ala  Ile Pro Ala Pro Asp  Ser Lys Arg 
    1205                 1210                 1215             


Gln Ser  Ile Leu Phe Ser Thr  Glu Val 
    1220                 1225         


<210>  1047
<211>  474
<212>  DNA
<213>  Homosapiens

<400>  1047
atgaagctgg gccagtactc ccggcctccg ccatttcgga ctgggagctc cgtggcgcag     60

gcactgaagg cggcggcagg gccagaggct cagcggctcc cagacctgct gaaaatgact    120

gaatataaac ttgcggtagt tggagctggt ggcgtaagca aaagtgtctt gacgatacag    180

ctaattcaga atcattttgt ggaccaatat gatccaacaa tagagaattc ctacaggaag    240

caagtagtaa ttgatggaga aacctgtctc ttggatattc ttgacacaac aggtcaagaa    300

gagtacaatg caatgaggac caatatgcac aattatagaa aacaaattaa aagatttaag    360

gactctgaag atgtgcctat ggtcctagta ggaaataaat gtgatttgcc ttctagaaca    420

gtagacacaa aaggctcagg acttagcaag gagttaggga attcccttta ttga          474


<210>  1048
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  1048

Met Lys Leu Gly Gln Tyr Ser Arg Pro Pro Pro Phe Arg Thr Gly Ser 
1               5                   10                  15      


Ser Val Ala Gln Ala Leu Lys Ala Ala Ala Gly Pro Glu Ala Gln Arg 
            20                  25                  30          


Leu Pro Asp Leu Leu Lys Met Thr Glu Tyr Lys Leu Ala Val Val Gly 
        35                  40                  45              


Ala Gly Gly Val Ser Lys Ser Val Leu Thr Ile Gln Leu Ile Gln Asn 
    50                  55                  60                  


His Phe Val Asp Gln Tyr Asp Pro Thr Ile Glu Asn Ser Tyr Arg Lys 
65                  70                  75                  80  


Gln Val Val Ile Asp Gly Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr 
                85                  90                  95      


Thr Gly Gln Glu Glu Tyr Asn Ala Met Arg Thr Asn Met His Asn Tyr 
            100                 105                 110         


Arg Lys Gln Ile Lys Arg Phe Lys Asp Ser Glu Asp Val Pro Met Val 
        115                 120                 125             


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
    130                 135                 140                 


Gly Ser Gly Leu Ser Lys Glu Leu Gly Asn Ser Leu Tyr 
145                 150                 155         


<210>  1049
<211>  583
<212>  DNA
<213>  Homosapiens

<400>  1049
acagagaaaa agagaaaaca acaacaaaaa tgaagcaaga gtaaactgcc aactccaact     60

gcctttctgg aaggcctaat ttgaagatgt ctgaaattct gtatcactgg ctcccagaca    120

tatcatgttt atttgtacat cacacctttg cccacctctg ctcagtggac ctccagccta    180

aaatgcctcc cttgttcctc tgtctcactt cagctgttat tgaagtctcc tggtacaatg    240

tgacatttcc agcgtcttgt tttccaatca gatcagtggc tctcagtgga ccaactgata    300

aggaacattt ggaaaatgtt acgatgattg agggctgtac tggtatttgg tgggcaggga    360

atgacaatgt cctgtgatgt atccatcata atggaaaatt atctgatgtc ttgggcaaat    420

aacagcagtc ctgccagaca aaatgaaggt gaaaaattca tttataattg cctaagttca    480

gagcttctct ctgttttaca tacaagtaca agaaatgttt ggcacagttt taatgtatac    540

tgaattatag gaatccaatt acaatatatt ttgcttaaca tag                      583


<210>  1050
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  1050

Met Ser Glu Ile Leu Tyr His Trp Leu Pro Asp Ile Ser Cys Leu Phe 
1               5                   10                  15      


Val His His Thr Phe Ala His Leu Cys Ser Val Asp Leu Gln Pro Lys 
            20                  25                  30          


Met Pro Pro Leu Phe Leu Cys Leu Thr Ser Ala Val Ile Glu Val Ser 
        35                  40                  45              


Trp Tyr Asn Val Thr Phe Pro Ala Ser Cys Phe Pro Ile Arg Ser Val 
    50                  55                  60                  


Ala Leu Ser Gly Pro Thr Asp Lys Glu His Leu Glu Asn Val Thr Met 
65                  70                  75                  80  


Ile Glu Gly Cys Thr Gly Ile Trp Trp Ala Gly Asn Asp Asn Val Leu 
                85                  90                  95      


<210>  1051
<211>  3167
<212>  DNA
<213>  Homosapiens

<400>  1051
aaaccttcgg cggccggcgc tgtgcggcgg gcgcggttgc gcgcggcttg gggcaaatac     60

ttctcaccac tgcatgaatg gacatttgaa agtgccatag ccaaacactt gcaagcatgg    120

agacctcatc aatgctttcc tcattgaatg atgagtgtaa atctgacaac tacattgagc    180

ctcactacaa ggaatggtat cgagtagcca ttgatattct gattgaacac gggttagaag    240

cataccaaga atttcttgtc caggaacgag tttcagactt tcttgctgag gaagaaatta    300

attatatttt gaaaaatgtc cagaaagttg cacaaagcac agcacatggt actgatgatt    360

cctgtgatga taccttatct tcagggacct actggcctgt tgagtctgat gtggaagctc    420

caaatcttga cttaggctgg ccatatgtga tgcccggact cttagggggc acccatatag    480

atctcctttt tcatccacca agagcacatc tacttacgat aaaagaaact attcggaaga    540

tgataaaaga agcaagaaag gtcattgctt tagtgatgga tatatttaca gatgtggaca    600

ttttcaaaga aatcgttgag gcatcaactc gaggagtatc tgtttacatt ctgcttgatg    660

agtccaattt taatcatttt ctaaatatga ctgagaaaca aggttgttca gttcagcgtc    720

tcaggaatat tcgagtgcga acagtaaaag gccaagatta tctttcaaaa acaggggcaa    780

aattccatgg aaaaatggaa cagaaatttt tgttagttga ctgccagaaa gtgatgtacg    840

gttcttacag ttatatgtgg tcatttgaga aagctcacct cagcatggtt cagataatta    900

caggacaact tgttgagtcc tttgatgaag aatttagaac tctctatgcc agatcctgtg    960

tccctagttc atttgctcag gaagaatcag caagggtgaa gcatggaaaa gccctctggg   1020

aaaatggcac ttaccagcat tcggtgtctt cattagcatc tgtttccagc cagagaaacc   1080

tttttggtag acaagacaag attcataaac tagattccag ttacttcaaa aacagaggga   1140

tatatacttt aaatgaacat gacaaatata acataagaag tcacggatac aaacctcatt   1200

ttgttcctaa ctttaatggt ccaaacgcaa tacgtcagtt tcaacccaat cagataaatg   1260

aaaattggaa aaggcatagt tatgctgggg aacagccaga aacagtgcca tacctcctgc   1320

ttaatagggc tctgaataga accaataatc cacctggtaa ttggaaaaag ccatctgata   1380

gtctcagtgt ggcgtcctca tcacgggaag gctatgtaag ccaccacaac acacctgccc   1440

agagttttgc caatcggctt gcgcagagaa aaacaacaaa tcttgcagac aggaattcaa   1500

atgttcggag gtcttttaat gggacagata accatatccg ctttttgcaa caacgaatgc   1560

caacccttga acataccaca aagtcattcc tacgtaactg gagaattgaa tcctacttaa   1620

atgatcattc agaagctaca ccggactcaa atggatcagc tttaggtgac cgatttgagg   1680

gctatgataa tcctgagaat ttgaaggcca atgcccttta tactcattct cggcttcgtt   1740

cctctttagt atttaaaccc actttacctg agcaaaagga agttaacagt tgtacaactg   1800

gctcctcaaa ttcaactatc attggttctc agggaagtga gacacctaaa gaggtcccag   1860

acacccctac gaatgtacag catttgacag acaaaccctt gccagaatca atccccaagc   1920

tcccattgca gtcagaggca ccaaaaatgc acaccttgca ggttcctgaa aaccactcag   1980

tagccttaaa ccaaactaca aatggccata ctgaatcaaa taactatata tataaaacct   2040

tgggtgtaaa taagcagaca gaaaatctaa agaatcaaca gactgagaat ctacttaaaa   2100

ggcgaagttt cccgttattt gacaactcaa aagccaactt agatcctgga aatagtaagc   2160

attatgtata tagtacactt accaggaatc gagttagaca accagaaaag cccaaagaag   2220

atttgctgaa aagttctaaa agcatgcaca atgtgactca taacttggag gaggatgagg   2280

aggaagttac caagagaaac tctccaagtg gcactactac caaatcagtt tccattgctg   2340

ctttacttga tgtgaataaa gaggaatcta acaaagaact tgcttcaaag aaggaagtta   2400

agggttcccc aagttttttg aaaaaggggt ctcagaagtt aaggtcatta cttagcctta   2460

ccccagataa gaaagaaaat ctatccaaaa ataaagcacc tgccttttat agattgtgta   2520

gtagctctga cacattagtt tctgagggtg aagaaaatca aaaaccaaag aaatcagaca   2580

caaaagttga ttcatctcct agaagaaagc attcttcctc atcgaattct caaggcagca   2640

tccacaagag taaggaagat gtaacagtta gcccatctca agagataaat gctccaccag   2700

atgaaaataa aagaacacct tctccaggtc cagttgaaag caagttcttg gaaagggcag   2760

gagatgcctc tgccccaaga tttaacactg aacagatcca ataccgagat tcaagggaga   2820

ttaatgcagt tgttacccct gaaagaagac ctacttcttc tccaaggcca acgtccagtg   2880

agcttctacg atctcattca actgatcggc gtgtttacag tcgttttgag ccgttttgta   2940

agattgagag ctctattcag ccaacaagca acatgccaaa taccagtata aatcgcccag   3000

aaataaaatc tgcgactatg ggcaacagtt atggcaggtc tagtccattg cttaattaca   3060

acactggtgt ttatcgctca tatcaaccca atgagaacaa gtttcgagga tttatgcaaa   3120

agtttggaaa ctttatacac aaaaataaat agctattaaa atgcaaa                 3167


<210>  1052
<211>  1011
<212>  PRT
<213>  Homosapiens

<400>  1052

Met Glu Thr Ser Ser Met Leu Ser Ser Leu Asn Asp Glu Cys Lys Ser 
1               5                   10                  15      


Asp Asn Tyr Ile Glu Pro His Tyr Lys Glu Trp Tyr Arg Val Ala Ile 
            20                  25                  30          


Asp Ile Leu Ile Glu His Gly Leu Glu Ala Tyr Gln Glu Phe Leu Val 
        35                  40                  45              


Gln Glu Arg Val Ser Asp Phe Leu Ala Glu Glu Glu Ile Asn Tyr Ile 
    50                  55                  60                  


Leu Lys Asn Val Gln Lys Val Ala Gln Ser Thr Ala His Gly Thr Asp 
65                  70                  75                  80  


Asp Ser Cys Asp Asp Thr Leu Ser Ser Gly Thr Tyr Trp Pro Val Glu 
                85                  90                  95      


Ser Asp Val Glu Ala Pro Asn Leu Asp Leu Gly Trp Pro Tyr Val Met 
            100                 105                 110         


Pro Gly Leu Leu Gly Gly Thr His Ile Asp Leu Leu Phe His Pro Pro 
        115                 120                 125             


Arg Ala His Leu Leu Thr Ile Lys Glu Thr Ile Arg Lys Met Ile Lys 
    130                 135                 140                 


Glu Ala Arg Lys Val Ile Ala Leu Val Met Asp Ile Phe Thr Asp Val 
145                 150                 155                 160 


Asp Ile Phe Lys Glu Ile Val Glu Ala Ser Thr Arg Gly Val Ser Val 
                165                 170                 175     


Tyr Ile Leu Leu Asp Glu Ser Asn Phe Asn His Phe Leu Asn Met Thr 
            180                 185                 190         


Glu Lys Gln Gly Cys Ser Val Gln Arg Leu Arg Asn Ile Arg Val Arg 
        195                 200                 205             


Thr Val Lys Gly Gln Asp Tyr Leu Ser Lys Thr Gly Ala Lys Phe His 
    210                 215                 220                 


Gly Lys Met Glu Gln Lys Phe Leu Leu Val Asp Cys Gln Lys Val Met 
225                 230                 235                 240 


Tyr Gly Ser Tyr Ser Tyr Met Trp Ser Phe Glu Lys Ala His Leu Ser 
                245                 250                 255     


Met Val Gln Ile Ile Thr Gly Gln Leu Val Glu Ser Phe Asp Glu Glu 
            260                 265                 270         


Phe Arg Thr Leu Tyr Ala Arg Ser Cys Val Pro Ser Ser Phe Ala Gln 
        275                 280                 285             


Glu Glu Ser Ala Arg Val Lys His Gly Lys Ala Leu Trp Glu Asn Gly 
    290                 295                 300                 


Thr Tyr Gln His Ser Val Ser Ser Leu Ala Ser Val Ser Ser Gln Arg 
305                 310                 315                 320 


Asn Leu Phe Gly Arg Gln Asp Lys Ile His Lys Leu Asp Ser Ser Tyr 
                325                 330                 335     


Phe Lys Asn Arg Gly Ile Tyr Thr Leu Asn Glu His Asp Lys Tyr Asn 
            340                 345                 350         


Ile Arg Ser His Gly Tyr Lys Pro His Phe Val Pro Asn Phe Asn Gly 
        355                 360                 365             


Pro Asn Ala Ile Arg Gln Phe Gln Pro Asn Gln Ile Asn Glu Asn Trp 
    370                 375                 380                 


Lys Arg His Ser Tyr Ala Gly Glu Gln Pro Glu Thr Val Pro Tyr Leu 
385                 390                 395                 400 


Leu Leu Asn Arg Ala Leu Asn Arg Thr Asn Asn Pro Pro Gly Asn Trp 
                405                 410                 415     


Lys Lys Pro Ser Asp Ser Leu Ser Val Ala Ser Ser Ser Arg Glu Gly 
            420                 425                 430         


Tyr Val Ser His His Asn Thr Pro Ala Gln Ser Phe Ala Asn Arg Leu 
        435                 440                 445             


Ala Gln Arg Lys Thr Thr Asn Leu Ala Asp Arg Asn Ser Asn Val Arg 
    450                 455                 460                 


Arg Ser Phe Asn Gly Thr Asp Asn His Ile Arg Phe Leu Gln Gln Arg 
465                 470                 475                 480 


Met Pro Thr Leu Glu His Thr Thr Lys Ser Phe Leu Arg Asn Trp Arg 
                485                 490                 495     


Ile Glu Ser Tyr Leu Asn Asp His Ser Glu Ala Thr Pro Asp Ser Asn 
            500                 505                 510         


Gly Ser Ala Leu Gly Asp Arg Phe Glu Gly Tyr Asp Asn Pro Glu Asn 
        515                 520                 525             


Leu Lys Ala Asn Ala Leu Tyr Thr His Ser Arg Leu Arg Ser Ser Leu 
    530                 535                 540                 


Val Phe Lys Pro Thr Leu Pro Glu Gln Lys Glu Val Asn Ser Cys Thr 
545                 550                 555                 560 


Thr Gly Ser Ser Asn Ser Thr Ile Ile Gly Ser Gln Gly Ser Glu Thr 
                565                 570                 575     


Pro Lys Glu Val Pro Asp Thr Pro Thr Asn Val Gln His Leu Thr Asp 
            580                 585                 590         


Lys Pro Leu Pro Glu Ser Ile Pro Lys Leu Pro Leu Gln Ser Glu Ala 
        595                 600                 605             


Pro Lys Met His Thr Leu Gln Val Pro Glu Asn His Ser Val Ala Leu 
    610                 615                 620                 


Asn Gln Thr Thr Asn Gly His Thr Glu Ser Asn Asn Tyr Ile Tyr Lys 
625                 630                 635                 640 


Thr Leu Gly Val Asn Lys Gln Thr Glu Asn Leu Lys Asn Gln Gln Thr 
                645                 650                 655     


Glu Asn Leu Leu Lys Arg Arg Ser Phe Pro Leu Phe Asp Asn Ser Lys 
            660                 665                 670         


Ala Asn Leu Asp Pro Gly Asn Ser Lys His Tyr Val Tyr Ser Thr Leu 
        675                 680                 685             


Thr Arg Asn Arg Val Arg Gln Pro Glu Lys Pro Lys Glu Asp Leu Leu 
    690                 695                 700                 


Lys Ser Ser Lys Ser Met His Asn Val Thr His Asn Leu Glu Glu Asp 
705                 710                 715                 720 


Glu Glu Glu Val Thr Lys Arg Asn Ser Pro Ser Gly Thr Thr Thr Lys 
                725                 730                 735     


Ser Val Ser Ile Ala Ala Leu Leu Asp Val Asn Lys Glu Glu Ser Asn 
            740                 745                 750         


Lys Glu Leu Ala Ser Lys Lys Glu Val Lys Gly Ser Pro Ser Phe Leu 
        755                 760                 765             


Lys Lys Gly Ser Gln Lys Leu Arg Ser Leu Leu Ser Leu Thr Pro Asp 
    770                 775                 780                 


Lys Lys Glu Asn Leu Ser Lys Asn Lys Ala Pro Ala Phe Tyr Arg Leu 
785                 790                 795                 800 


Cys Ser Ser Ser Asp Thr Leu Val Ser Glu Gly Glu Glu Asn Gln Lys 
                805                 810                 815     


Pro Lys Lys Ser Asp Thr Lys Val Asp Ser Ser Pro Arg Arg Lys His 
            820                 825                 830         


Ser Ser Ser Ser Asn Ser Gln Gly Ser Ile His Lys Ser Lys Glu Asp 
        835                 840                 845             


Val Thr Val Ser Pro Ser Gln Glu Ile Asn Ala Pro Pro Asp Glu Asn 
    850                 855                 860                 


Lys Arg Thr Pro Ser Pro Gly Pro Val Glu Ser Lys Phe Leu Glu Arg 
865                 870                 875                 880 


Ala Gly Asp Ala Ser Ala Pro Arg Phe Asn Thr Glu Gln Ile Gln Tyr 
                885                 890                 895     


Arg Asp Ser Arg Glu Ile Asn Ala Val Val Thr Pro Glu Arg Arg Pro 
            900                 905                 910         


Thr Ser Ser Pro Arg Pro Thr Ser Ser Glu Leu Leu Arg Ser His Ser 
        915                 920                 925             


Thr Asp Arg Arg Val Tyr Ser Arg Phe Glu Pro Phe Cys Lys Ile Glu 
    930                 935                 940                 


Ser Ser Ile Gln Pro Thr Ser Asn Met Pro Asn Thr Ser Ile Asn Arg 
945                 950                 955                 960 


Pro Glu Ile Lys Ser Ala Thr Met Gly Asn Ser Tyr Gly Arg Ser Ser 
                965                 970                 975     


Pro Leu Leu Asn Tyr Asn Thr Gly Val Tyr Arg Ser Tyr Gln Pro Asn 
            980                 985                 990         


Glu Asn Lys Phe Arg Gly Phe Met  Gln Lys Phe Gly Asn  Phe Ile His 
        995                 1000                 1005             


Lys Asn  Lys 
    1010     


<210>  1053
<211>  7259
<212>  DNA
<213>  Homosapiens

<400>  1053
gtcactttta tttgggggtg tggacagctg ctttcccagg ggagtacttc ttacagtggg     60

atttcaagac aagatcggcc tgaagaaaaa ttatatttgt atatttttta aaaagtggga    120

actttgaggc tcagagacag agcagaagac agaacctggt cttctgattc cctgtgttct    180

gcttttttca ttgttccact ggacgctcat cagagggaag atctttttcc tcaattgatt    240

ccaacaatgt ctcacccatc ttggctgcca cccaaaagca ctggtgagcc cctcggccat    300

gtgcctgcac ggatggagac cacccattcc tttgggaacc ccagcatttc agtgtctaca    360

caacagccac ccaaaaagtt tgccccggta gttgctccaa aacctaagta caacccatac    420

aaacaacctg gaggtgaggg tgattttctt ccacccccac ctccacctct agatgattcc    480

agtgcccttc catctatctc tggaaacttt cctcctccac cacctcttga tgaagaggct    540

ttcaaagtac aggggaatcc cggaggcaag acacttgagg agaggcgctc cagcctggac    600

gctgagattg actccttgac cagcatcttg gctgaccttg agtgcagctc cccctataag    660

cctcggcctc cacagagctc cactggttca acagcctctc ctccagtttc gaccccagtc    720

acaggacaca agagaatggt catcccgaac caaccccctc taacagcaac caagaagtct    780

acattgaaac cacagcctgc accccaggct ggacccatcc ctgtggctcc aatcggaaca    840

ctcaaacccc agcctcagcc agtcccagcc tcctacacca cggcctccac ttcttcaagg    900

cctaccttta atgtgcaggt gaagtcagcc cagcccagcc ctcattatat ggctgcccct    960

tcatcaggac aaatttatgg ctcagggccc cagggctata acactcagcc agttcctgtc   1020

tctgggcagt gtccacctcc ttcaacacgg ggaggcatgg attatgccta cattccacca   1080

ccaggacttc agccggagcc tgggtatggg tatgccccca accagggacg ctattatgaa   1140

ggctactatg cagcagggcc aggctatggg ggcagaaatg actctgaccc tacctatggt   1200

caacaaggtc acccaaatac ctggaaacgg gaaccagggt acactcctcc tggagcaggg   1260

aaccagaacc ctcctgggat gtatccagtc actggtccca agaagaccta tatcacagat   1320

cctgtttcag ccccctgtgc gccaccattg cagccaaagg gtggccattc agggcaactg   1380

gggccttcgt cagttgcccc ttcattccgc ccagaggatg agcttgagca cctgaccaaa   1440

aagatgctgt atgacatgga aaatccacct gctgacgaat actttggccg ctgtgctcgc   1500

tgtggagaaa acgtagttgg ggaaggtaca ggatgcactg ccatggatca ggtcttccac   1560

gtggattgtt ttacctgcat catctgcaac aacaagctcc gagggcagcc attctatgct   1620

gtggaaaaga aagcatactg cgagccctgc tacattaata ctctggagca gtgcaatgtg   1680

tgttccaagc ccatcatgga gcggattctc cgagccaccg ggaaggccta tcatcctcac   1740

tgtttcacct gcgtgatgtg ccaccgcagc ctggatggga tcccattcac tgtggatgct   1800

ggcgggctca ttcactgcat tgaggacttc cacaagaaat ttgccccgcg atgttctgtg   1860

tgcaaggagc ctattatgcc agccccgggc caggaggaga ctgtccgtat tgtggctttg   1920

gatcgagatt tccatgttca ctgctaccga tgcgaggatt gcggtggtct cctgtctgaa   1980

ggagataacc aaggctgcta ccccttggat gggcacatcc tctgcaagac ctgcaactct   2040

gcccgcatca gggtgttgac cgccaaggcg agcactgacc tttagattca gtcacctgtt   2100

cagccggcac tgagaagaac gaacacaaga aaaagataag aaatactaga gtaaaggcca   2160

tcaaactacg cgatagtctc tgttcttcat ctgctattaa ccttgcctta gaaacacata   2220

aattatgaga ttttttttaa aagttgttac caaatacaca tttcacattg aatcatgtag   2280

gatcttgatg ggcctttgtt cccaaggact tccacatttt tgcacagatt atgctccatc   2340

ccattcactt ctgcattcct gtaactttta atccctatgt ttgtctcact tttcatctgg   2400

ttgaatggct tttcttagtg tggtatttgc tgtcacatag tttttcctgg gtgagtctgc   2460

caactcacag gtgcttttag gcttgaaatc tccatcctat catttccgtt ttgcctgtga   2520

ctgtaaagag tagccattct tttcccatgt attgaagagg atattcttct cttgctttat   2580

actactcacg tccttgggga gggaaatgca caattttttt ttgttaggct gtaaagaatt   2640

taagctgtaa attacataag ttagaacaag cccaaattta atttgcaacc atcagaattc   2700

agaatctata gtgaccagtg atcaaggcta attggaaaag agttatcggc ccatagctaa   2760

taagtagtga cagacaacca agcttcaata tttttctaaa gaaattacag gtgggatatg   2820

ctagaaaagg cattttgggg ttatgtttaa aaaaacatta ttgtcccaca atattacctt   2880

aagatttttc ttttccgcac tacctgaaca ttgtaataca gacaaacttg atttcttcta   2940

gaagataaca ttttcaatac tgtcccactt ctcatcttaa aaatattgtc atgtttattc   3000

taatatccaa cacaactatc aaaattgcct ttttctctag aggatgaagg ctgtgaaaaa   3060

accgttcaaa ttctcttctt tttctttttt attaccaggt ccattttgcc tgacaattgc   3120

aaatcagagc atacaaaata aaactgtgca gttttgtttg gtttactttc aaaagagtag   3180

aaagcttgaa aagattctga aaccacagtt tcattattct cataatcctt ctgcaactga   3240

aattacatat tgcaggagac attttcatat catcaatgtg acatttacac cacactttca   3300

aagacaatca ctgaaacaaa aattgtcttt atgagctaaa aatatgcaga atctctgcct   3360

agaatcttta ttcaaacttt tattagccag tgaaacactt gcttgccaac tgccaagcca   3420

tacttattaa gttcgaacat gtttcactta aggagagaca cctagcttag tcatggcaag   3480

ttgccatttt gtaaactaag gattttggac tgagatttct taaatctttc ttcaaatctc   3540

ccacaagtat atacttttaa attatggagt attttaagtc tacaaaaagg tataaataat   3600

aatataatga attcctatat acctaatacc cagtttaaga caccaaatat aacaagtata   3660

attacatcct ccaatgtacc gtttccttat tccacagata tctttttcat tattgtgaag   3720

tgatgttcag atttctagtt ttttttctag tttttaattt taacatcaga actgaaataa   3780

aaaattatgg atacgtgttt tgaattgcaa actattcctc aggaattcca attaaattta   3840

ttttacttga ataggaatga tcataaaagt gattcttttt ttgtgactag aaattcttaa   3900

gccgatggtc actatagctc atccttaatg tatggctcat ttgcttttgt cactaaacgg   3960

ttttgtgtta gaaccaccaa aattatagct tttaagagct tcctttgacc actgtctttt   4020

tcttacccta gttctcttat ctttgatcgt atatttctca taatgtgaaa tatgatgaga   4080

ttcacttagg ggcagcatgt tagttttggg aggcaatgtc aactgtgtct ctgaattcct   4140

gtcttccaaa ttgaagccag accatgctga tgacctcaag tagcactgac tatttgacaa   4200

tagggctgat aatgtaatcg gcttgaattt tgacttagta actttttatg taatactttc   4260

ggagaaattc tctttaggac aaagcagaga gtccaattta ttgagggata gattgtatct   4320

cttaaagtgg tcatattatt attaattttg ccaaaagaag aagaatttat tgaatattta   4380

tactataaaa tgcagtaaca ttctacttgc ttattacatt taaatccttg tgtaactgaa   4440

tgtttacatg tcaagaggaa aagctgtaag aaaatgctgt cacagaccca tccctgtggc   4500

atcgtcagca gaatactgct tgcttacaat ctttattatg cattcttata acataacctc   4560

agagtatctt taccaaaggt ttttaaagta aatctctttt taagatagac ttattctttt   4620

ataataatga atgtgcactc atacatatgt agaaacattt agatttagag tttttttttt   4680

ctttcacaag gtataataag gaaaggatcc tacaatattt tattctaggg tttcttaaat   4740

atatgattta tattactgtc ttttctatta atcatttgat ttaaacaatg ccaagtcact   4800

cttttttagt tgcatgaaat tttgcctgca acagagagaa aaagattgta ttactttaat   4860

gattataatc atactgtctg ctgatataat atcataattg ttgtggttta aatacataaa   4920

tagtagaaaa atcagagtct ataacagaaa gtttgtaaaa atatactgat tttgaaaagt   4980

atcaggaata taaatatttg gtaattctgt gtaacaagag agacatggaa aaggaaaaaa   5040

atccactata tcatgggctc tgcagaacat atcaaaatag gatttcttaa atttttcaac   5100

ccccagacca tactgactca acatggagtc tcactggcca agaaaattgc ctttaaaact   5160

cgaaaataag gccaggtgtg gtgactcaca cttgtaatcc cagcaatttg ggaggctgag   5220

acaggaggat tgcctgaggc caggagtttg acaccagcct gggcaacata gtgagacctt   5280

gtctctacaa aaaataaaat aaaataaaaa ccaaattagc cagacatggt ggcatgcgct   5340

tgtttaaaaa aacaaataaa taaataatcg actcaaaaat aagtcatgtg tcccagcata   5400

aggcatcagg ttgttagatg ctggcatctc tgcagctcaa agatgtgggt tctttttctt   5460

gtcattaaca cattgttatt tctgtaggag caacttctct gatcaaaatt acttttctgg   5520

gtatgtgctg attaaggggg tggacttatc aacactataa ttgttcccta tgaaagattc   5580

cacagagatg tttatggtga ggtttaaagg atatgaaact ctacatttaa acaagtattt   5640

tatatttggg tacagaggaa gaaagagagg gctttttcca tggggctata gtagagagtt   5700

agtggaatat agacaggact ctgaaaacac aacttccagc cattttttta gttagtaaaa   5760

atcctattaa tgtgaaccag ccaggaataa cagtgttatt tctattggat atggtttggg   5820

cttctcttgt caaatctgtg tcggctgccc cctgatcctt ccattatcaa gttttgaagg   5880

gtgttgggga aattatggca gctgctaggg agatcaggga aacactgatg taacctcaaa   5940

gcctctcacc attcctcttg gcttggaaag gctttatttt ttcatataca tttctagaaa   6000

tattgctatt ctaccttagt atttcacatt tgtagttcaa acaagcgatt gtccatctgt   6060

tgcctagagc tatagtacat gtgtgttatg aatgaaatat gacagcatgt tccatacccc   6120

tgctttagcc atctgtggga aaccagcaaa ctgaaaaaga cacctctgca aaatgtgcct   6180

caagtccatt tcttgggatc gctcgtttgg tgcactctcg tgggagacaa tcagagaaca   6240

acatatactt gtgccttatt ttcaaagaat ctatttacac tactatgaat attccactga   6300

agagtcaatg atgtaaatga taaccaccaa atctcaaaaa tatactcacc aaaaagtaaa   6360

aaagtaaaaa aaaaaaaaaa agaaagaaag aaaagaaaga gagagaagtc aacttttcat   6420

cttaatatat tctagtagta tttatttttt ccttgtcttg gaagtatctc ataggtcttt   6480

aaatgagtaa aacattttta tgccagaagg tgatataatg gatgttagtg ttttttattt   6540

gattttacag tagttttagt cagataatga ggacagagac ttcaacttga ttctttacca   6600

ccattcagca tattttttaa ttgtcttcat tgtatttgct taatagtggt ccagacaagt   6660

tcaaaacttg ttctcagtga ggcattaata tggtgcaacc atgaatattt caggccaagt   6720

tattcacttg acagataact agaatgaaac ttttctcatg aggctgttgt ttggttagca   6780

tagccttatt tcaaacctta aaaagttacc tgactgaagc tactatgact tggtaaggat   6840

tcttcctctc ttgctttctt cctcccttcc tttcttcctc ttccttcctc ctcttcttat   6900

tttctttcct actttccatc ctacctatta gtgttgctgt acttggattt tttgtaaatt   6960

aaatcaatgc attatgattt tagggaatta tgattatatt cataagggga aggctaccag   7020

aaaatatatg tggcatccat aaaatcttct tttatagggg catatttttt aggttgtatt   7080

tattcgtaaa gtgaaatgag ataatagagt ctttctgttt catgttaatg aattttcatc   7140

agggactgag gtcatagatt cttggaaaat tcatttgtga ctgatctagt tttctcagct   7200

gtatgcaaag taatctttca aagactaggt taagattttt tttttaagtc tgaagcaat    7259


<210>  1054
<211>  612
<212>  PRT
<213>  Homosapiens

<400>  1054

Met Ser His Pro Ser Trp Leu Pro Pro Lys Ser Thr Gly Glu Pro Leu 
1               5                   10                  15      


Gly His Val Pro Ala Arg Met Glu Thr Thr His Ser Phe Gly Asn Pro 
            20                  25                  30          


Ser Ile Ser Val Ser Thr Gln Gln Pro Pro Lys Lys Phe Ala Pro Val 
        35                  40                  45              


Val Ala Pro Lys Pro Lys Tyr Asn Pro Tyr Lys Gln Pro Gly Gly Glu 
    50                  55                  60                  


Gly Asp Phe Leu Pro Pro Pro Pro Pro Pro Leu Asp Asp Ser Ser Ala 
65                  70                  75                  80  


Leu Pro Ser Ile Ser Gly Asn Phe Pro Pro Pro Pro Pro Leu Asp Glu 
                85                  90                  95      


Glu Ala Phe Lys Val Gln Gly Asn Pro Gly Gly Lys Thr Leu Glu Glu 
            100                 105                 110         


Arg Arg Ser Ser Leu Asp Ala Glu Ile Asp Ser Leu Thr Ser Ile Leu 
        115                 120                 125             


Ala Asp Leu Glu Cys Ser Ser Pro Tyr Lys Pro Arg Pro Pro Gln Ser 
    130                 135                 140                 


Ser Thr Gly Ser Thr Ala Ser Pro Pro Val Ser Thr Pro Val Thr Gly 
145                 150                 155                 160 


His Lys Arg Met Val Ile Pro Asn Gln Pro Pro Leu Thr Ala Thr Lys 
                165                 170                 175     


Lys Ser Thr Leu Lys Pro Gln Pro Ala Pro Gln Ala Gly Pro Ile Pro 
            180                 185                 190         


Val Ala Pro Ile Gly Thr Leu Lys Pro Gln Pro Gln Pro Val Pro Ala 
        195                 200                 205             


Ser Tyr Thr Thr Ala Ser Thr Ser Ser Arg Pro Thr Phe Asn Val Gln 
    210                 215                 220                 


Val Lys Ser Ala Gln Pro Ser Pro His Tyr Met Ala Ala Pro Ser Ser 
225                 230                 235                 240 


Gly Gln Ile Tyr Gly Ser Gly Pro Gln Gly Tyr Asn Thr Gln Pro Val 
                245                 250                 255     


Pro Val Ser Gly Gln Cys Pro Pro Pro Ser Thr Arg Gly Gly Met Asp 
            260                 265                 270         


Tyr Ala Tyr Ile Pro Pro Pro Gly Leu Gln Pro Glu Pro Gly Tyr Gly 
        275                 280                 285             


Tyr Ala Pro Asn Gln Gly Arg Tyr Tyr Glu Gly Tyr Tyr Ala Ala Gly 
    290                 295                 300                 


Pro Gly Tyr Gly Gly Arg Asn Asp Ser Asp Pro Thr Tyr Gly Gln Gln 
305                 310                 315                 320 


Gly His Pro Asn Thr Trp Lys Arg Glu Pro Gly Tyr Thr Pro Pro Gly 
                325                 330                 335     


Ala Gly Asn Gln Asn Pro Pro Gly Met Tyr Pro Val Thr Gly Pro Lys 
            340                 345                 350         


Lys Thr Tyr Ile Thr Asp Pro Val Ser Ala Pro Cys Ala Pro Pro Leu 
        355                 360                 365             


Gln Pro Lys Gly Gly His Ser Gly Gln Leu Gly Pro Ser Ser Val Ala 
    370                 375                 380                 


Pro Ser Phe Arg Pro Glu Asp Glu Leu Glu His Leu Thr Lys Lys Met 
385                 390                 395                 400 


Leu Tyr Asp Met Glu Asn Pro Pro Ala Asp Glu Tyr Phe Gly Arg Cys 
                405                 410                 415     


Ala Arg Cys Gly Glu Asn Val Val Gly Glu Gly Thr Gly Cys Thr Ala 
            420                 425                 430         


Met Asp Gln Val Phe His Val Asp Cys Phe Thr Cys Ile Ile Cys Asn 
        435                 440                 445             


Asn Lys Leu Arg Gly Gln Pro Phe Tyr Ala Val Glu Lys Lys Ala Tyr 
    450                 455                 460                 


Cys Glu Pro Cys Tyr Ile Asn Thr Leu Glu Gln Cys Asn Val Cys Ser 
465                 470                 475                 480 


Lys Pro Ile Met Glu Arg Ile Leu Arg Ala Thr Gly Lys Ala Tyr His 
                485                 490                 495     


Pro His Cys Phe Thr Cys Val Met Cys His Arg Ser Leu Asp Gly Ile 
            500                 505                 510         


Pro Phe Thr Val Asp Ala Gly Gly Leu Ile His Cys Ile Glu Asp Phe 
        515                 520                 525             


His Lys Lys Phe Ala Pro Arg Cys Ser Val Cys Lys Glu Pro Ile Met 
    530                 535                 540                 


Pro Ala Pro Gly Gln Glu Glu Thr Val Arg Ile Val Ala Leu Asp Arg 
545                 550                 555                 560 


Asp Phe His Val His Cys Tyr Arg Cys Glu Asp Cys Gly Gly Leu Leu 
                565                 570                 575     


Ser Glu Gly Asp Asn Gln Gly Cys Tyr Pro Leu Asp Gly His Ile Leu 
            580                 585                 590         


Cys Lys Thr Cys Asn Ser Ala Arg Ile Arg Val Leu Thr Ala Lys Ala 
        595                 600                 605             


Ser Thr Asp Leu 
    610         


<210>  1055
<211>  4052
<212>  DNA
<213>  Homosapiens

<400>  1055
gaggcaagtg aggagagaag atgctgtagc gtcctcaccg gctgccagca gggaaatggt     60

ccaggagtgc tgggtgtgag cctcccttct cctcaagccg gagactgcgg ttgtcattga    120

tcaattgaag aagcaaggac ccgaaatcac agacattagc aatgatgtgt gaagtgatgc    180

ccacgattaa tgaggacacc ccaatgagcc aaagggggtc ccaaagcagt ggctcggact    240

cagactccca ttttgagcag ctgatggtga atatgctaga tgaaagggat cgtcttctag    300

acacccttcg ggagacccag gaaagcctct cacttgccca gcaaagactt caggatgtca    360

tctatgaccg agactcactc cagagacagc tcaattcagc cctgccacag gatatcgaat    420

ccctaacagg agggctggct ggttctaagg gggctgatcc accggaattt gctgcactga    480

caaaagaatt aaatgcctgc agggaacaac ttctagaaaa ggaagaagaa atctctgaac    540

ttaaagctga aagaaacaac acaagactat tactggagca tttggagtgc cttgtgtcac    600

gacatgaaag atcactaaga atgacggtgg taaaacggca agcccagtct ccctcaggag    660

tatccagtga agttgaagtt ctcaaggcac tgaaatcttt gtttgagcac cacaaggcct    720

tggatgaaaa ggtaagggag cgactgaggg tttctttaga aagagtctct gcactggaag    780

aagaactagc tgctgctaat caggagattg ttgccttgcg tgaacaaaat gttcatatac    840

aaagaaaaat ggcatcaagc gagggatcca cagagtcaga acatcttgaa gggatggaac    900

ctggacagaa agtccatgag aagcgtttgt ccaatggttc tatagactca accgatgaaa    960

ctagtcaaat agttgaacta caagaattgc ttgaaaagca aaactatgaa atggcccaga   1020

tgaaagaacg tttagcagcc ctttcttccc gagtgggaga ggtggaacag gaagcagaga   1080

cagcaagaaa ggatctcatt aaaacagaag aaatgaacac caagtatcaa agggacatta   1140

gggaggccat ggcacaaaag gaagatatgg aagaaagaat tacaaccctt gaaaagcgtt   1200

acctcagtgc tcagagagaa tctacctcca tacatgacat gaatgataaa ctagaaaatg   1260

agttagcaaa taaagaagct atcctgcggc agatggaaga gaaaaacaga cagttacaag   1320

aacgtcttga gctagctgaa caaaagttgc agcagaccat gagaaaggct gaaaccttgc   1380

ctgaagtaga ggctgaactg gctcagagaa ttgcagccct aaccaaggct gaagagagac   1440

atggaaatat tgaagaacgt atgagacatt tagagggtca acttgaagag aagaatcaag   1500

aacttcaaag agctaggcaa agagagaaaa tgaatgagga gcataacaag agattatcgg   1560

atacggttga tagacttctg actgaatcca atgaacgcct acaactacac ttaaaggaaa   1620

gaatggctgc tctagaagaa aagaatgttt taattcaaga atcagaaact ttcagaaaga   1680

atcttgaaga atctttacat gataaggaaa gattagcaga agaaattgaa aagctgagat   1740

ctgaacttga ccaattgaaa atgagaactg gctctttaat tgaacccaca ataccaagaa   1800

ctcatctaga cacctcagct gagttgcggt actcagtggg atccctagtg gacagccagt   1860

ctgattacag aacaactaaa gtaataagaa gaccaaggag aggccgcatg ggtgtgcgaa   1920

gagatgagcc aaaggtgaaa tctcttgggg atcacgagtg gaatagaact caacagattg   1980

gagtactaag cagccaccct tttgaaagtg acactgaaat gtctgatatt gatgatgatg   2040

acagagaaac aatttttagc tcaatggatc ttctctctcc aagtggtcat tccgatgccc   2100

agacgctagc catgatgctt caggaacaat tggatgccat caacaaagaa atcaggctaa   2160

ttcaggaaga aaaagaatct acagagttgc gtgctgaaga aattgaaaat agagtggcta   2220

gtgtgagcct cgaaggcctg aatttggcaa gggtccaccc aggtacctcc attactgcct   2280

ctgttacagc ttcatcgctg gccagttcat ctccccccag tggacactca actccaaagc   2340

tcacccctcg aagccctgcc agggaaatgg atcggatggg agtcatgaca ctgccaagtg   2400

atctgaggaa acatcggaga aagattgcag ttgtggaaga agatggtcga gaggacaaag   2460

caacaattaa atgtgaaact tctcctcctc ctacccctag agccctcaga atgactcaca   2520

ctctcccttc ttcctaccac aatgatgctc gaagtagttt atctgtctct cttgagccag   2580

aaagcctcgg gcttggtagt gccaacagca gccaagactc tcttcacaaa gcccccaaga   2640

agaaaggaat caagtcttca ataggacgtt tgtttggtaa aaaagaaaaa gctcgacttg   2700

ggcagctccg aggctttatg gagactgaag ctgcagctca ggagtccctg gggttaggca   2760

aactcggaac tcaagctgag aaggatcgaa gactaaagaa aaagcatgaa cttcttgaag   2820

aagctcggag aaagggatta ccttttgccc agtgggatgg gccaactgtg gtcgcatggc   2880

tagagctttg gttgggaatg cctgcgtggt acgtggcagc ctgccgagcc aacgtgaaga   2940

gtggtgccat catgtctgct ttatctgaca ctgagatcca gagagaaatt ggaatcagca   3000

atccactgca tcgcttaaaa cttcgattag caatccagga gatggtttcc ctaacaagtc   3060

cttcagctcc tccaacatct cgaactcctt caggcaacgt ttgggtgact catgaagaaa   3120

tggaaaatct tgcagctcca gcaaaaacga aagaatctga ggaaggaagc tgggcccagt   3180

gtccggtttt tctacagacc ctggcttatg gagatatgaa tcatgagtgg attggaaatg   3240

aatggcttcc cagcttgggg ttacctcagt acagaagtta ctttatggaa tgcttggtag   3300

atgcaagaat gttagatcac ctaacaaaaa aagatctccg tgtccattta aaaatggtgg   3360

atagtttcca tcgaacaagt ttacaatatg gaattatgtg cttaaagagg ttgaattatg   3420

acagaaaaga actagaaaga agacgggaag caagccaaca tgaaataaaa gacgtgttgg   3480

tgtggagcaa tgaccgagtt attcgctgga tacaagcaat tggacttcga gaatatgcaa   3540

ataatatact tgagagcggt gtgcatggct cacttatagc cctggatgaa aactttgact   3600

acagcagctt agctttatta ttacagattc caacacagaa cacccaggca aggcagattc   3660

ttgaaagaga atacaataac ctcttggccc tgggaactga aaggcgactg gatgaaagtg   3720

atgacaagaa cttcagacgt ggatcaacct ggagaaggca gtttcctcct cgtgaagtac   3780

atggaatcag catgatgcct gggtcctcag aaacattacc agctggattt aggttaacca   3840

caacctctgg gcagtcaaga aaaatgacaa cagatgttgc ttcatcaaga ctgcagaggt   3900

tagacaactc cactgttcgc acatactcat gttgaccagc cactcaaagg aggcagcact   3960

gacctgctat ggcgtctttt cagtctactc tacctaaagt gcactaccat ctaagaagac   4020

gagcagtgaa aacctttgtg aaaactgaat tc                                 4052


<210>  1056
<211>  1257
<212>  PRT
<213>  Homosapiens

<400>  1056

Met Met Cys Glu Val Met Pro Thr Ile Asn Glu Asp Thr Pro Met Ser 
1               5                   10                  15      


Gln Arg Gly Ser Gln Ser Ser Gly Ser Asp Ser Asp Ser His Phe Glu 
            20                  25                  30          


Gln Leu Met Val Asn Met Leu Asp Glu Arg Asp Arg Leu Leu Asp Thr 
        35                  40                  45              


Leu Arg Glu Thr Gln Glu Ser Leu Ser Leu Ala Gln Gln Arg Leu Gln 
    50                  55                  60                  


Asp Val Ile Tyr Asp Arg Asp Ser Leu Gln Arg Gln Leu Asn Ser Ala 
65                  70                  75                  80  


Leu Pro Gln Asp Ile Glu Ser Leu Thr Gly Gly Leu Ala Gly Ser Lys 
                85                  90                  95      


Gly Ala Asp Pro Pro Glu Phe Ala Ala Leu Thr Lys Glu Leu Asn Ala 
            100                 105                 110         


Cys Arg Glu Gln Leu Leu Glu Lys Glu Glu Glu Ile Ser Glu Leu Lys 
        115                 120                 125             


Ala Glu Arg Asn Asn Thr Arg Leu Leu Leu Glu His Leu Glu Cys Leu 
    130                 135                 140                 


Val Ser Arg His Glu Arg Ser Leu Arg Met Thr Val Val Lys Arg Gln 
145                 150                 155                 160 


Ala Gln Ser Pro Ser Gly Val Ser Ser Glu Val Glu Val Leu Lys Ala 
                165                 170                 175     


Leu Lys Ser Leu Phe Glu His His Lys Ala Leu Asp Glu Lys Val Arg 
            180                 185                 190         


Glu Arg Leu Arg Val Ser Leu Glu Arg Val Ser Ala Leu Glu Glu Glu 
        195                 200                 205             


Leu Ala Ala Ala Asn Gln Glu Ile Val Ala Leu Arg Glu Gln Asn Val 
    210                 215                 220                 


His Ile Gln Arg Lys Met Ala Ser Ser Glu Gly Ser Thr Glu Ser Glu 
225                 230                 235                 240 


His Leu Glu Gly Met Glu Pro Gly Gln Lys Val His Glu Lys Arg Leu 
                245                 250                 255     


Ser Asn Gly Ser Ile Asp Ser Thr Asp Glu Thr Ser Gln Ile Val Glu 
            260                 265                 270         


Leu Gln Glu Leu Leu Glu Lys Gln Asn Tyr Glu Met Ala Gln Met Lys 
        275                 280                 285             


Glu Arg Leu Ala Ala Leu Ser Ser Arg Val Gly Glu Val Glu Gln Glu 
    290                 295                 300                 


Ala Glu Thr Ala Arg Lys Asp Leu Ile Lys Thr Glu Glu Met Asn Thr 
305                 310                 315                 320 


Lys Tyr Gln Arg Asp Ile Arg Glu Ala Met Ala Gln Lys Glu Asp Met 
                325                 330                 335     


Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg Tyr Leu Ser Ala Gln Arg 
            340                 345                 350         


Glu Ser Thr Ser Ile His Asp Met Asn Asp Lys Leu Glu Asn Glu Leu 
        355                 360                 365             


Ala Asn Lys Glu Ala Ile Leu Arg Gln Met Glu Glu Lys Asn Arg Gln 
    370                 375                 380                 


Leu Gln Glu Arg Leu Glu Leu Ala Glu Gln Lys Leu Gln Gln Thr Met 
385                 390                 395                 400 


Arg Lys Ala Glu Thr Leu Pro Glu Val Glu Ala Glu Leu Ala Gln Arg 
                405                 410                 415     


Ile Ala Ala Leu Thr Lys Ala Glu Glu Arg His Gly Asn Ile Glu Glu 
            420                 425                 430         


Arg Met Arg His Leu Glu Gly Gln Leu Glu Glu Lys Asn Gln Glu Leu 
        435                 440                 445             


Gln Arg Ala Arg Gln Arg Glu Lys Met Asn Glu Glu His Asn Lys Arg 
    450                 455                 460                 


Leu Ser Asp Thr Val Asp Arg Leu Leu Thr Glu Ser Asn Glu Arg Leu 
465                 470                 475                 480 


Gln Leu His Leu Lys Glu Arg Met Ala Ala Leu Glu Glu Lys Asn Val 
                485                 490                 495     


Leu Ile Gln Glu Ser Glu Thr Phe Arg Lys Asn Leu Glu Glu Ser Leu 
            500                 505                 510         


His Asp Lys Glu Arg Leu Ala Glu Glu Ile Glu Lys Leu Arg Ser Glu 
        515                 520                 525             


Leu Asp Gln Leu Lys Met Arg Thr Gly Ser Leu Ile Glu Pro Thr Ile 
    530                 535                 540                 


Pro Arg Thr His Leu Asp Thr Ser Ala Glu Leu Arg Tyr Ser Val Gly 
545                 550                 555                 560 


Ser Leu Val Asp Ser Gln Ser Asp Tyr Arg Thr Thr Lys Val Ile Arg 
                565                 570                 575     


Arg Pro Arg Arg Gly Arg Met Gly Val Arg Arg Asp Glu Pro Lys Val 
            580                 585                 590         


Lys Ser Leu Gly Asp His Glu Trp Asn Arg Thr Gln Gln Ile Gly Val 
        595                 600                 605             


Leu Ser Ser His Pro Phe Glu Ser Asp Thr Glu Met Ser Asp Ile Asp 
    610                 615                 620                 


Asp Asp Asp Arg Glu Thr Ile Phe Ser Ser Met Asp Leu Leu Ser Pro 
625                 630                 635                 640 


Ser Gly His Ser Asp Ala Gln Thr Leu Ala Met Met Leu Gln Glu Gln 
                645                 650                 655     


Leu Asp Ala Ile Asn Lys Glu Ile Arg Leu Ile Gln Glu Glu Lys Glu 
            660                 665                 670         


Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Asn Arg Val Ala Ser Val 
        675                 680                 685             


Ser Leu Glu Gly Leu Asn Leu Ala Arg Val His Pro Gly Thr Ser Ile 
    690                 695                 700                 


Thr Ala Ser Val Thr Ala Ser Ser Leu Ala Ser Ser Ser Pro Pro Ser 
705                 710                 715                 720 


Gly His Ser Thr Pro Lys Leu Thr Pro Arg Ser Pro Ala Arg Glu Met 
                725                 730                 735     


Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu Arg Lys His Arg 
            740                 745                 750         


Arg Lys Ile Ala Val Val Glu Glu Asp Gly Arg Glu Asp Lys Ala Thr 
        755                 760                 765             


Ile Lys Cys Glu Thr Ser Pro Pro Pro Thr Pro Arg Ala Leu Arg Met 
    770                 775                 780                 


Thr His Thr Leu Pro Ser Ser Tyr His Asn Asp Ala Arg Ser Ser Leu 
785                 790                 795                 800 


Ser Val Ser Leu Glu Pro Glu Ser Leu Gly Leu Gly Ser Ala Asn Ser 
                805                 810                 815     


Ser Gln Asp Ser Leu His Lys Ala Pro Lys Lys Lys Gly Ile Lys Ser 
            820                 825                 830         


Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Ala Arg Leu Gly Gln 
        835                 840                 845             


Leu Arg Gly Phe Met Glu Thr Glu Ala Ala Ala Gln Glu Ser Leu Gly 
    850                 855                 860                 


Leu Gly Lys Leu Gly Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys 
865                 870                 875                 880 


Lys His Glu Leu Leu Glu Glu Ala Arg Arg Lys Gly Leu Pro Phe Ala 
                885                 890                 895     


Gln Trp Asp Gly Pro Thr Val Val Ala Trp Leu Glu Leu Trp Leu Gly 
            900                 905                 910         


Met Pro Ala Trp Tyr Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly 
        915                 920                 925             


Ala Ile Met Ser Ala Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly 
    930                 935                 940                 


Ile Ser Asn Pro Leu His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu 
945                 950                 955                 960 


Met Val Ser Leu Thr Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Pro 
                965                 970                 975     


Ser Gly Asn Val Trp Val Thr His Glu Glu Met Glu Asn Leu Ala Ala 
            980                 985                 990         


Pro Ala Lys Thr Lys Glu Ser Glu  Glu Gly Ser Trp Ala  Gln Cys Pro 
        995                 1000                 1005             


Val Phe  Leu Gln Thr Leu Ala  Tyr Gly Asp Met Asn  His Glu Trp 
    1010                 1015                 1020             


Ile Gly  Asn Glu Trp Leu Pro  Ser Leu Gly Leu Pro  Gln Tyr Arg 
    1025                 1030                 1035             


Ser Tyr  Phe Met Glu Cys Leu  Val Asp Ala Arg Met  Leu Asp His 
    1040                 1045                 1050             


Leu Thr  Lys Lys Asp Leu Arg  Val His Leu Lys Met  Val Asp Ser 
    1055                 1060                 1065             


Phe His  Arg Thr Ser Leu Gln  Tyr Gly Ile Met Cys  Leu Lys Arg 
    1070                 1075                 1080             


Leu Asn  Tyr Asp Arg Lys Glu  Leu Glu Arg Arg Arg  Glu Ala Ser 
    1085                 1090                 1095             


Gln His  Glu Ile Lys Asp Val  Leu Val Trp Ser Asn  Asp Arg Val 
    1100                 1105                 1110             


Ile Arg  Trp Ile Gln Ala Ile  Gly Leu Arg Glu Tyr  Ala Asn Asn 
    1115                 1120                 1125             


Ile Leu  Glu Ser Gly Val His  Gly Ser Leu Ile Ala  Leu Asp Glu 
    1130                 1135                 1140             


Asn Phe  Asp Tyr Ser Ser Leu  Ala Leu Leu Leu Gln  Ile Pro Thr 
    1145                 1150                 1155             


Gln Asn  Thr Gln Ala Arg Gln  Ile Leu Glu Arg Glu  Tyr Asn Asn 
    1160                 1165                 1170             


Leu Leu  Ala Leu Gly Thr Glu  Arg Arg Leu Asp Glu  Ser Asp Asp 
    1175                 1180                 1185             


Lys Asn  Phe Arg Arg Gly Ser  Thr Trp Arg Arg Gln  Phe Pro Pro 
    1190                 1195                 1200             


Arg Glu  Val His Gly Ile Ser  Met Met Pro Gly Ser  Ser Glu Thr 
    1205                 1210                 1215             


Leu Pro  Ala Gly Phe Arg Leu  Thr Thr Thr Ser Gly  Gln Ser Arg 
    1220                 1225                 1230             


Lys Met  Thr Thr Asp Val Ala  Ser Ser Arg Leu Gln  Arg Leu Asp 
    1235                 1240                 1245             


Asn Ser  Thr Val Arg Thr Tyr  Ser Cys 
    1250                 1255         


<210>  1057
<211>  3226
<212>  DNA
<213>  Homosapiens

<400>  1057
tcccgctcct gcggctcagc gtggtggcct cccctcgccc gccaccccgg caactttctc     60

tgcccgctcc cgcgtgtggg ggctgccgtg ccgggggcta actgggggca gcctctggag    120

aacggcttca gagtcccgga gacgcccgcc acccgcagcc tgcccgcggt gggcctgccg    180

tcggatctcg gcaccctctc ctcccctctc cccgaaccat gaccgagatg agcgagaagg    240

agaacgaacc ggatgacgcg gccacccaca gccccccagg gaccgtctcc gccctccagg    300

aaaccaagct ccagcgattc aagcgctccc tctccctcaa gaccatcctc cgaagtaaga    360

gcttggagaa cttcttcctt cgctcgggct ctgagctcaa gtgccccacc gaggtgctgc    420

tgacgccccc aaccccactg ccccctccct ccccaccacc cacagcctcg gacaggggcc    480

tggctacccc atccccctcc ccatgcccag tcccacgccc cctggcagcg ctcaaaccag    540

tgaggctgca cagcttccag gaacatgtct tcaagcgagc tagcccttgt gagctgtgcc    600

accagctcat cgtaggaaac tccaaacagg gcttgcgatg taagatgtgc aaagtcagcg    660

tccacctctg gtgctctgag gagatctccc accagcaatg cccaggcaag acgtccacct    720

ccttccgccg caacttcagt tcccctctcc tggtgcatga gccgccacca gtctgtgcca    780

caagcaaaga gtccccaccc actggggaca gtgggaaggt ggaccctgtc tacgagaccc    840

tgcgctatgg cacctccctg gcactgatga accgctccag tttcagcagc acctctgagt    900

ccccgacaag gagcctgagt gagcgggatg agctgaccga ggatggggaa ggcagcatcc    960

gcagctctga ggaggggcct ggtgacagtg catctccagt attcacagcc ccagcagaga   1020

gtgaagggcc aggaccagag gagaagagtc ctggacagca gctccccaaa gccaccctgc   1080

ggaaggatgt ggggcccatg tactcctacg ttgcactcta caagtttctg ccccaggaga   1140

acaatgatct ggctctgcag cctggagatc ggatcatgct ggtggatgac tctaacgagg   1200

actggtggaa gggcaagatc ggcgaccggg ttggcttctt cccagctaat tttgtgcaac   1260

gggtgaggcc aggcgagaat gtttggcgct gctgccaacc cttctccggg aacaaggaac   1320

agggttacat gagcctcaag gagaaccaga tctgcgtggg cgtgggcaga agcaaggatg   1380

ctgacggctt catccgcgtc agcagtggca agaagcgggg cctggtgcca gtcgacgccc   1440

tgactgagat ctgagaggag ccaagggaac ccagatgaca cccttgccca tgcctggacc   1500

ttgcttctgg ccagggaggg gatcaggccc ccttgtccac tccataccct tcctccctct   1560

gtccctctcc taggtgccac ttaccgtggc ttaggagcct tttgtactgg ggaagatttt   1620

atttcttggg tggggtgccc tgagtgggtt gatcctctgg gacttggcgg ggatggggtg   1680

gggtgggagg gaatgaggaa gctacaggta ggtccaccca acgcccaggc accccagtct   1740

acttgctggg ctgagtccag ccctggggaa gattcctggg gaatttattt gctgcttctc   1800

ccagccttcc cctgcccaca ccacctgcgc atgcctggca caaccctctc cccacagagc   1860

ctctgcttgg gtctatgtgt gtgtgaccgt gcatctgctc ctttgcaagt ggggtcttgg   1920

gagcaggcct ttttgtgtcc tcggccctcc acccttggtg gggaggggac ccaggaccat   1980

aggaaggtcc tgagtccacc tcctggtctc cacctctgtc attccgtcaa ttctcaggaa   2040

agttttgcag gaatctctcc cgttacttga aacctgggcg gacagatgag gggaaggctg   2100

aggtccctgg aaggtgtaac aaatcagaga ctatctgttc aagtagaaaa cccaagagct   2160

ggccaggtgt ggtggctcat gcctgtaatc ccagcacttt gggaggctga ggtgggcaga   2220

tcacctgagg tcaggagttc aagaccagcc tggccaacat ggtgaaaccc cctctctact   2280

aaaagtacga aacttagcca ggcatgatgg gggtctgcct gtaatgccag ctactccaga   2340

ggctgaggca agagaatcac ttgaacccgg gaggcggagg tttcagtgag ccgagattgc   2400

accattgcac cccagcctgg gcaacagagc gagactccgt ctcaaaaaaa aaaaaagaaa   2460

gaaagaaaag gaaacccaag agctgcctgg acacacggaa acccaactga gaacaaaatc   2520

ctggcccgtg cttggtcaaa gcaaacccat ttcactgtca ggacccccgg tcacacagga   2580

accacccgcc aggggagcct gtgactgtca gttcctgtcc caggctttgc ccggccgccc   2640

caggaaccca accctctggg ctgacctttc tcctgcttct ctccaggctc tgcaggggac   2700

agggcaggtg ctgcaggagc ccctttgctg gctttatctg ctcccttgtt ctggacacag   2760

agccctggga aaaagagggg gtggaagaca gacaaggaag gtggaatgtt ctgttttggc   2820

caccaggaaa tggggtgggg tgggcataca cagagaggac ccctctctta atacagctgc   2880

ttttctcggt gccaacctcc ctcccccaag ctcagatcct cctcttatgc ccttgattgt   2940

gccagcccat gccaccccca tcctgggcac agttacaccc tcccatgcag tgggagaaac   3000

acagaccctc gtacccaaag gcccctgccc cacttctccc ccacaaagcg gggtctcaag   3060

ccacactgcc ctgtttgctg ccatgaggcc ccccccccca gcaatatccc aggggcgggc   3120

ccaatgccca ctgtacatga ggctgcatga tgggtctggg gccttgctga ttccccagac   3180

ccctaattaa atgtttcttg tcccagccca aaaaaaaaaa aaaaaa                  3226


<210>  1058
<211>  411
<212>  PRT
<213>  Homosapiens

<400>  1058

Met Thr Glu Met Ser Glu Lys Glu Asn Glu Pro Asp Asp Ala Ala Thr 
1               5                   10                  15      


His Ser Pro Pro Gly Thr Val Ser Ala Leu Gln Glu Thr Lys Leu Gln 
            20                  25                  30          


Arg Phe Lys Arg Ser Leu Ser Leu Lys Thr Ile Leu Arg Ser Lys Ser 
        35                  40                  45              


Leu Glu Asn Phe Phe Leu Arg Ser Gly Ser Glu Leu Lys Cys Pro Thr 
    50                  55                  60                  


Glu Val Leu Leu Thr Pro Pro Thr Pro Leu Pro Pro Pro Ser Pro Pro 
65                  70                  75                  80  


Pro Thr Ala Ser Asp Arg Gly Leu Ala Thr Pro Ser Pro Ser Pro Cys 
                85                  90                  95      


Pro Val Pro Arg Pro Leu Ala Ala Leu Lys Pro Val Arg Leu His Ser 
            100                 105                 110         


Phe Gln Glu His Val Phe Lys Arg Ala Ser Pro Cys Glu Leu Cys His 
        115                 120                 125             


Gln Leu Ile Val Gly Asn Ser Lys Gln Gly Leu Arg Cys Lys Met Cys 
    130                 135                 140                 


Lys Val Ser Val His Leu Trp Cys Ser Glu Glu Ile Ser His Gln Gln 
145                 150                 155                 160 


Cys Pro Gly Lys Thr Ser Thr Ser Phe Arg Arg Asn Phe Ser Ser Pro 
                165                 170                 175     


Leu Leu Val His Glu Pro Pro Pro Val Cys Ala Thr Ser Lys Glu Ser 
            180                 185                 190         


Pro Pro Thr Gly Asp Ser Gly Lys Val Asp Pro Val Tyr Glu Thr Leu 
        195                 200                 205             


Arg Tyr Gly Thr Ser Leu Ala Leu Met Asn Arg Ser Ser Phe Ser Ser 
    210                 215                 220                 


Thr Ser Glu Ser Pro Thr Arg Ser Leu Ser Glu Arg Asp Glu Leu Thr 
225                 230                 235                 240 


Glu Asp Gly Glu Gly Ser Ile Arg Ser Ser Glu Glu Gly Pro Gly Asp 
                245                 250                 255     


Ser Ala Ser Pro Val Phe Thr Ala Pro Ala Glu Ser Glu Gly Pro Gly 
            260                 265                 270         


Pro Glu Glu Lys Ser Pro Gly Gln Gln Leu Pro Lys Ala Thr Leu Arg 
        275                 280                 285             


Lys Asp Val Gly Pro Met Tyr Ser Tyr Val Ala Leu Tyr Lys Phe Leu 
    290                 295                 300                 


Pro Gln Glu Asn Asn Asp Leu Ala Leu Gln Pro Gly Asp Arg Ile Met 
305                 310                 315                 320 


Leu Val Asp Asp Ser Asn Glu Asp Trp Trp Lys Gly Lys Ile Gly Asp 
                325                 330                 335     


Arg Val Gly Phe Phe Pro Ala Asn Phe Val Gln Arg Val Arg Pro Gly 
            340                 345                 350         


Glu Asn Val Trp Arg Cys Cys Gln Pro Phe Ser Gly Asn Lys Glu Gln 
        355                 360                 365             


Gly Tyr Met Ser Leu Lys Glu Asn Gln Ile Cys Val Gly Val Gly Arg 
    370                 375                 380                 


Ser Lys Asp Ala Asp Gly Phe Ile Arg Val Ser Ser Gly Lys Lys Arg 
385                 390                 395                 400 


Gly Leu Val Pro Val Asp Ala Leu Thr Glu Ile 
                405                 410     


<210>  1059
<211>  1632
<212>  DNA
<213>  Homosapiens

<400>  1059
atgattttat ggaaatacag aaggctctta cgcaagtgcc tgacatactt cccggctgtg     60

gcatctggga cagccaggtc cccaggggct ggagaaggcc cccccacacc ccctgctgcc    120

tccagcccct ggagcttggg acactggcat ggagccaccc tcccactgcc cgtggcactg    180

tccctaactc gccctggtgt cctgaagcca ctgctcctgt cctctagtct attcccctta    240

cccacccaca aagcatctgt taccaaggta gaggccccag gtgaggggcc agtgggtgca    300

gcccaacccc acgctgagct gtttcacagc cggccctgcc ccctctccaa gatgctgttt    360

tggcacaacc agccggagca tctatggccc agtcctgggg acctataccc tgggcccccc    420

agcagcctgc tcagggagcc cctgcccttg ccctacttga agcaggagga gctgcccaac    480

atccctggca cggagctgcc ctgccccatg ttctagtacg tgctctgtgc agccacctcg    540

ccagccgtga agcagcagga ggagaccctc acctacctga accaggatgt gccactgtcc    600

gtgggagtga tagaacccca agtgctgctc tcacaactca acatggtgga gtttcactgg    660

gacccaacaa agaggacatc tctcttcctg cagttcacac ctcggaagaa aggtggagag    720

aaaggcatcc ctttccgcct ccagatcgac accttcaggc ccagtgacaa ggggctgccg    780

ctagaccacc tgcactcagc tggctgcctc atcaaggtgt ttaaggtaca ggcagcaatg    840

gggcccattt tcctctctct cagggctgtc acctggcctc gccggctcac aaaggagcgg    900

aaactgaaaa tggaccgtga gaagatggag aaacagcccc tgcatgagag ggacaagtat    960

cagaccgcct gcgagagcac tgtcttcttg gaggtgtgtg tgttggggcg agagcaggag   1020

gggagagttg gagaaaagat cctcacgtgt tcgccatggc cggagtcccc tgcaaggccc   1080

cggccacctc tcagctctct ggctctgacc tctccccact cctgcaggct cttgtcccca   1140

gaaaggctct gttcctcacc accattcgct ctggatacct tggggtgtag cccagttgag   1200

gatctgaacc aaaaagcccc catctcagag acacagcaat ggttgcatca gcactggttc   1260

tccagctact gccggatgct ggccaacttc actggtctgg atctgctgaa gcttacatgc   1320

caggacctta tccaaatctg cggggctgct gatgggatcc gccttttcaa tactcttaga   1380

gccaggtgct ggacactgcc aaccagggtc cccttcccac tgtagtggcc cttactaact   1440

tagctagcag gtaggaatct agtcctcttt ttccatacag aaaaccactt tttttttttt   1500

ttttttttcc tgagatggag tttcgctctt ttgcccaggc tggagtgaag tggtgaagtg   1560

gcacgatctc agttaccgca ccaggcccag aaaaccactt ttatattaaa cagtaaacgc   1620

tttcttaaaa ga                                                       1632


<210>  1060
<211>  474
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (172)..(172)
<223>  Xaa can be any naturally occurring amino acid

<400>  1060

Met Ile Leu Trp Lys Tyr Arg Arg Leu Leu Arg Lys Cys Leu Thr Tyr 
1               5                   10                  15      


Phe Pro Ala Val Ala Ser Gly Thr Ala Arg Ser Pro Gly Ala Gly Glu 
            20                  25                  30          


Gly Pro Pro Thr Pro Pro Ala Ala Ser Ser Pro Trp Ser Leu Gly His 
        35                  40                  45              


Trp His Gly Ala Thr Leu Pro Leu Pro Val Ala Leu Ser Leu Thr Arg 
    50                  55                  60                  


Pro Gly Val Leu Lys Pro Leu Leu Leu Ser Ser Ser Leu Phe Pro Leu 
65                  70                  75                  80  


Pro Thr His Lys Ala Ser Val Thr Lys Val Glu Ala Pro Gly Glu Gly 
                85                  90                  95      


Pro Val Gly Ala Ala Gln Pro His Ala Glu Leu Phe His Ser Arg Pro 
            100                 105                 110         


Cys Pro Leu Ser Lys Met Leu Phe Trp His Asn Gln Pro Glu His Leu 
        115                 120                 125             


Trp Pro Ser Pro Gly Asp Leu Tyr Pro Gly Pro Pro Ser Ser Leu Leu 
    130                 135                 140                 


Arg Glu Pro Leu Pro Leu Pro Tyr Leu Lys Gln Glu Glu Leu Pro Asn 
145                 150                 155                 160 


Ile Pro Gly Thr Glu Leu Pro Cys Pro Met Phe Xaa Tyr Val Leu Cys 
                165                 170                 175     


Ala Ala Thr Ser Pro Ala Val Lys Gln Gln Glu Glu Thr Leu Thr Tyr 
            180                 185                 190         


Leu Asn Gln Asp Val Pro Leu Ser Val Gly Val Ile Glu Pro Gln Val 
        195                 200                 205             


Leu Leu Ser Gln Leu Asn Met Val Glu Phe His Trp Asp Pro Thr Lys 
    210                 215                 220                 


Arg Thr Ser Leu Phe Leu Gln Phe Thr Pro Arg Lys Lys Gly Gly Glu 
225                 230                 235                 240 


Lys Gly Ile Pro Phe Arg Leu Gln Ile Asp Thr Phe Arg Pro Ser Asp 
                245                 250                 255     


Lys Gly Leu Pro Leu Asp His Leu His Ser Ala Gly Cys Leu Ile Lys 
            260                 265                 270         


Val Phe Lys Val Gln Ala Ala Met Gly Pro Ile Phe Leu Ser Leu Arg 
        275                 280                 285             


Ala Val Thr Trp Pro Arg Arg Leu Thr Lys Glu Arg Lys Leu Lys Met 
    290                 295                 300                 


Asp Arg Glu Lys Met Glu Lys Gln Pro Leu His Glu Arg Asp Lys Tyr 
305                 310                 315                 320 


Gln Thr Ala Cys Glu Ser Thr Val Phe Leu Glu Val Cys Val Leu Gly 
                325                 330                 335     


Arg Glu Gln Glu Gly Arg Val Gly Glu Lys Ile Leu Thr Cys Ser Pro 
            340                 345                 350         


Trp Pro Glu Ser Pro Ala Arg Pro Arg Pro Pro Leu Ser Ser Leu Ala 
        355                 360                 365             


Leu Thr Ser Pro His Ser Cys Arg Leu Leu Ser Pro Glu Arg Leu Cys 
    370                 375                 380                 


Ser Ser Pro Pro Phe Ala Leu Asp Thr Leu Gly Cys Ser Pro Val Glu 
385                 390                 395                 400 


Asp Leu Asn Gln Lys Ala Pro Ile Ser Glu Thr Gln Gln Trp Leu His 
                405                 410                 415     


Gln His Trp Phe Ser Ser Tyr Cys Arg Met Leu Ala Asn Phe Thr Gly 
            420                 425                 430         


Leu Asp Leu Leu Lys Leu Thr Cys Gln Asp Leu Ile Gln Ile Cys Gly 
        435                 440                 445             


Ala Ala Asp Gly Ile Arg Leu Phe Asn Thr Leu Arg Ala Arg Cys Trp 
    450                 455                 460                 


Thr Leu Pro Thr Arg Val Pro Phe Pro Leu 
465                 470                 


<210>  1061
<211>  2423
<212>  DNA
<213>  Homosapiens

<400>  1061
gagagccgag ctagcgacga gcagtcgttg cggccgccgg cgccgcggga ggtggtggag     60

gcctagccgg agccgagagg tctcttgttc ccgtcccacg gtcccggcgt cacccctccg    120

gcgcccagtc cccgtcccgg aactcccggg cctgtcctgg gcccccggtc tgtgcactcc    180

gctcgccgca gcgcccggcc cgggccgcac ccgccggccc catgaggagg gacgtgaacg    240

gagtgaccaa gagcaggttt gagatgttct caaatagtga tgaagctgta atcaataaaa    300

aacttcccaa agaactcctg ttacggatat tttcttttct agatgttgtt accctgtgcc    360

gctgtgctca ggtctccagg gcctggaatg ttctggctct ggatggcagt aactggcagc    420

gaattgacct atttgatttc cagagggata ttgagggccg agtagtggag aatatttcaa    480

aacgatgtgg gggcttttta cgaaagttaa gtcttcgtgg atgtcttgga gtgggagaca    540

atgcattaag aacctttgca caaaactgca ggaacattga agtactgaat ctaaatgggt    600

gtacaaagac aacagacgct acatgtacta gccttagcaa gttctgttcc aaactcaggc    660

accttgactt ggcttcctgt acatcaataa caaacatgtc tctaaaagct ctgagtgagg    720

gatgtccact gttggagcag ttgaacattt cctggtgtga ccaagtaacc aaggatggca    780

ttcaagcact agtgaggggc tgtgggggtc tcaaggcctt attcttaaaa ggctgcacgc    840

agctagaaga tgaagctctc aagtacatag gtgcacactg ccctgaactg gtgactttga    900

acttgcagac ttgcttgcaa atcacagatg aaggtctcat tactatatgc agagggtgcc    960

ataagttaca atccctttgt gcctctggct gctccaacat cacagatgcc atcctgaatg   1020

ctctaggtca gaactgccca cggcttagaa tattggaagt ggcaagatgt tctcaattaa   1080

cagatgtggg ctttaccact ctagccagga attgccatga acttgaaaag atggacctgg   1140

aagagtgtgt tcagataaca gatagcacat taatccaact ttctatacac tgtcctcgac   1200

ttcaagtatt gagtctgtct cactgtgagc tgatcacaga tgatggaatt cgtcacctgg   1260

ggaatggggc ctgcgcccat gaccagctgg aggtgattga gctggacaac tgcccactaa   1320

tcacagatgc atccctggag cacttgaaga gctgtcatag ccttgagcgg atagaactct   1380

atgactgcca gcaaatcaca cgggctggaa tcaagagact caggacccat ttacccaata   1440

ttaaagtcca cgcctacttc gcacctgtca ctccaccccc atcagtaggg ggcagcagac   1500

agcgcttctg cagatgctgc atcatcctat gacaatggag gtggtcaacc ttggcgaact   1560

gagtatttaa tgacacttct agagctaccg tggagtctct ccagtggaag caaccccagt   1620

gttctgagca agggttacaa agtgagggag ggcagtgtcc agatccccag agccacacat   1680

acatacacat acacaccctt acccccatcc actctagctt tgtgaccatg ggactgaagt   1740

ttgtgatggc ttttttatca agtagattgg taaaatttaa ccattcctgt tgaggtgccc   1800

ataagaaaat cataggccaa gatagggagg ggcattccag caaaccccgt gttaatgcta   1860

ctgtggtttt taaatttttg tctaggggtt tctttgggga ttttagaaca gcatctgctg   1920

tcctccgggg tcaagaaaag catggaaaga caatatatga tgtacccagg gaccagaaag   1980

aaaatttctt tgcatcttag aaatggtaga cattcattgt gactaaagag cttctatgct   2040

tccttgtttc catgccaaca tgctgagcat gctcacaaag aaggctcgtc cattcctcct   2100

gtgttttagt atttggccca gaggtttcct aaatggttgc cttgaaatca ctgtggtcca   2160

aatgtaattc ttacacactc aaattatcac tgtctgtagc acacttgtgc acctgtctta   2220

cattctctgt tgctcccccc cacactcttg ctcagtctgt cacctgttca gtctgcttac   2280

tcactcaatt gttacccttt tgctgttgtc gtgtttacag tttgcatttt gaatgattag   2340

ttgggattac caaacatttt ttaaaaagat attatcaata aatatttttt taattctaaa   2400

ttttaaaaaa aaaaaaaaaa aaa                                           2423


<210>  1062
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  1062

Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe Glu Met Phe 
1               5                   10                  15      


Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys Glu Leu 
            20                  25                  30          


Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys Arg Cys 
        35                  40                  45              


Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu Gly Arg 
65                  70                  75                  80  


Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg Lys Leu 
                85                  90                  95      


Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg Thr Phe 
            100                 105                 110         


Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly Cys Thr 
        115                 120                 125             


Lys Thr Thr Asp Ala Thr Cys Thr Ser Leu Ser Lys Phe Cys Ser Lys 
    130                 135                 140                 


Leu Arg His Leu Asp Leu Ala Ser Cys Thr Ser Ile Thr Asn Met Ser 
145                 150                 155                 160 


Leu Lys Ala Leu Ser Glu Gly Cys Pro Leu Leu Glu Gln Leu Asn Ile 
                165                 170                 175     


Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu Val Arg 
            180                 185                 190         


Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr Gln Leu 
        195                 200                 205             


Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu Leu Val 
    210                 215                 220                 


Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly Leu Ile 
225                 230                 235                 240 


Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala Ser Gly 
                245                 250                 255     


Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln Asn Cys 
            260                 265                 270         


Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu Thr Asp 
        275                 280                 285             


Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met 
    290                 295                 300                 


Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile Gln Leu 
305                 310                 315                 320 


Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His Cys Glu 
                325                 330                 335     


Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala Cys Ala 
            340                 345                 350         


His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu Ile Thr 
        355                 360                 365             


Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu Arg Ile 
    370                 375                 380                 


Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys Arg Leu 
385                 390                 395                 400 


Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala Pro Val 
                405                 410                 415     


Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys Arg Cys 
            420                 425                 430         


Cys Ile Ile Leu 
        435     


<210>  1063
<211>  5809
<212>  DNA
<213>  Homosapiens

<400>  1063
gggaagatgg cggcggcctc gagcaccctt ctcttcttgc cgccggggac ttcagattga     60

tccttcccgg gaagagtagg gactgctggt gccctgcgtc ccgggatccc gagccaactt    120

gtttcctccg ttagtggtgg ggaagggctt atccttttgt ggcggatcta gcttctcctc    180

gccttcagga tgaaagctca gggggaaacc gaggagtcag aaaagctgag taagatgagt    240

tctctcctgg aacggctcca tgcaaaattt aaccaaaata gaccctggag tgaaaccatt    300

aagcttgtgc gtcaagtcat ggagaagagg gttgtgatga gttctggagg gcatcaacat    360

ttggtcagct gtttggagac attgcagaag gctctcaaag taacatcttt accagcaatg    420

actgatcgtt tggagtccat agcaagacag aatggactgg gctctcatct cagtgccagt    480

ggcactgaat gttacatcac gtcagatatg ttctatgtgg aagtgcagtt agatcctgca    540

ggacagcttt gtgatgtaaa agtggctcac catggggaga atcctgtgag ctgtccggag    600

cttgtacagc agctaaggga aaaaaatttt gatgaatttt ctaagcacct taagggcctt    660

gttaatctgt ataaccttcc aggggacaac aaactgaaga ctaaaatgta cttggctctc    720

caatccttag aacaagatct ttctaaaatg gcaattatgt actggaaagc aactaatgct    780

ggtcccttgg ataagattct tcatggaagt gttggctatc tcacaccaag gagtgggggt    840

catttaatga acctgaagta ctatgtctct ccttctgacc tactggatga caagactgca    900

tctcccatca ttttgcatga gaataatgtt tctcgatctt tgggcatgaa tgcatcagtg    960

acaattgaag gaacatctgc tgtgtacaaa ctcccaattg caccattaat tatggggtca   1020

catccagttg acaataaatg gaccccttcc ttctcctcaa tcaccagtgc caacagtgtt   1080

gatcttcctg cctgtttctt cttgaaattt ccccagccaa tcccagtatc tagagcattt   1140

gttcagaaac tgcagaactg cacaggaatt ccattgtttg aaactcaacc aacttatgca   1200

cccctgtatg aactgatcac tcagtttgag ctatcaaagg accctgaccc catacctttg   1260

aatcacaaca tgagatttta tgctgctctt cctggtcagc agcactgcta tttcctcaac   1320

aaggatgctc ctcttccaga tggccgaagt ctacagggaa cccttgttag caaaatcacc   1380

tttcagcacc ctggccgagt tcctcttatc ctaaatctga tcagacacca agtggcctat   1440

aacaccctca ttggaagctg tgtcaaaaga actattctga aagaagattc tcctgggctt   1500

ctccaatttg aagtgtgtcc tctctcagag tctcgtttca gcgtatcttt tcagcaccct   1560

gtgaatgact ccctggtgtg tgtggtaatg gatgtgcagg actcaacaca tgtgagctgt   1620

aaactctaca aagggctgtc ggatgcactg atctgcacag atgacttcat tgccaaagtt   1680

gttcaaagat gtatgtccat ccctgtgacg atgagggcta ttcggaggaa agctgaaacc   1740

attcaagccg acaccccagc actgtccctc attgcagaga cagttgaaga catggtgaaa   1800

aagaacctgc ccccggctag cagcccaggg tatggcatga ccacaggcaa caacccaatg   1860

agtggtacca ctacaccaac caacaccttt ccggggggtc ccattaccac cttgtttaat   1920

atgagcatga gcatcaaaga tcggcatgag tcggtgggcc atggggagga cttcagcaag   1980

gtgtctcaga acccaattct taccagtttg ttgcaaatca cagggaacgg ggggtctacc   2040

attggctcga gtccgacccc tcctcatcac acgccgccac ctgtctcttc gatggccggc   2100

aacaccaaga accacccgat gctcatgaac cttcttaaag ataatcctgc ccaggatttc   2160

tcaacccttt atggaagcag ccctttagaa aggcagaact cctcttccgg ctcaccccgc   2220

atggaaatat gctcggggag caacaagacc aagaaaaaga agtcatcaag attaccacct   2280

gagaaaccaa agcaccagac tgaagatgac tttcagaggg agctattttc aatggatgtt   2340

gactcacaga accctatctt tgatgtcaac atgacagctg acacgctgga tacgccacac   2400

atcactccag ctccaagcca gtgtagcact cccccaacaa cttacccaca accagtacct   2460

cacccccaac ccagtattca aaggatggtc cgactatcca gttcagacag cattggccca   2520

gatgtaactg acatcctttc agacattgca gaagaagctt ctaaacttcc cagcactagt   2580

gatgattgcc cagccattgg cacccctctt cgagattctt caagctctgg gcattctcag   2640

agtaccctgt ttgactctga tgtctttcaa actaacaata atgaaaatcc atacactgat   2700

ccagctgatc ttattgcaga tgctgctgga agccccagta gtgactctcc taccaatcat   2760

ttttttcatg atggagtaga tttcaatcct gatttattga acagccagag ccaaagtggt   2820

tttggagaag aatattttga tgaaagcagc caaagtgggg ataatgatga tttcaaagga   2880

tttgcatctc aggcactaaa tactttgggg gtgccaatgc ttggaggtga taatggggag   2940

accaagttta agggcaataa ccaagccgac acagttgatt tcagtattat ttcagtagcc   3000

ggcaaagctt tagctcctgc agatcttatg gagcatcaca gtggtagtca gggtccttta   3060

ctgaccactg gggacttagg gaaagaaaag actcaaaaga gggtaaagga aggcaatggc   3120

accagtaata gtactctctc ggggcccgga ttagacagca aaccagggaa gcgcagtcgg   3180

accccttcta atgatgggaa aagcaaagat aagcctccaa agcggaagaa ggcagacact   3240

gagggaaagt ctccatctca tagttcttct aacagacctt ttaccccacc taccagtaca   3300

ggtggatcta aatcgccagg cagtgcagga agatctcaga ctcccccagg tgttgccaca   3360

ccacccattc ccaaaatcac tattcagatt cctaagggaa cagtgatggt gggcaagcct   3420

tcctctcaca gtcagtatac cagcagtggt tctgtgtctt cctcaggcag caaaagccac   3480

catagccatt cttcctcctc ttcctcatct gcttccacct cagggaagat gaaaagcagt   3540

aaatcagaag gttcatcaag ttccaagtta agtagcagta tgtattctag ccaggggtct   3600

tctggatcta gccagtccaa aaattcatcc cagtctgggg ggaagccagg ctcctctccc   3660

ataaccaagc atggactgag cagtggctct agcagcacca agatgaaacc tcaaggaaag   3720

ccatcatcac ttatgaatcc ttctttaagt aaaccaaaca tatccccttc tcattcaagg   3780

ccacctggag gctctgacaa gcttgcctct ccaatgaagc ctgttcctgg aactcctcca   3840

tcctctaaag ccaagtcccc tatcagttca ggttctggtg gttctcatat gtctggaact   3900

agttcaagct ctggcatgaa gtcatcttca gggttaggat cctcaggctc gttgtcccag   3960

aaaactcccc catcatctaa ttcctgtacg gcatcttcct cctccttttc ctcaagtggc   4020

tcttccatgt catcctctca gaaccagcat gggagttcta aaggaaaatc tcccagcaga   4080

aacaagaagc cgtccttgac agctgtcata gataaactga agcatggggt tgtcaccagt   4140

ggccctgggg gtgaagaccc actggacggc cagatggggg tgagcacaaa ttcttccagc   4200

catcctatgt cctccaaaca taacatgtca ggaggagagt ttcagggcaa gcgtgagaaa   4260

agtgataaag acaaatcaaa ggtttccacc tccgggagtt cagtggattc ttctaagaag   4320

acctcagagt caaaaaatgt ggggagcaca ggtgtggcaa aaattatcat cagtaagcat   4380

gatggaggct cccctagcat taaagccaaa gtgactttgc agaaacctgg ggaaagtagt   4440

ggagaagggc ttaggcctca aatggcttct tctaaaaact atggctctcc actcatcagt   4500

ggttccactc caaagcatga gcgtggctct cccagccata gtaagtcacc agcatatacc   4560

ccccagaatc tggacagtga aagtgagtca ggctcctcca tagcagagaa atcttatcag   4620

aatagtccca gctcagacga tggtatccga ccacttccag aatacagcac agagaaacat   4680

aagaagcaca aaaaggaaaa gaagaaagta aaagacaaag atagggaccg agaccgggac   4740

aaagaccgag acaagaaaaa atctcatagc atcaagccag agagttggtc caaatcaccc   4800

atctcttcag accagtcctt gtctatgaca agtaacacaa tcttatctgc agacagaccc   4860

tcaaggctca gcccagactt tatgattggg gaggaagatg atgatcttat ggatgtggcc   4920

ctgattggga attaggaacc ttatttccta aaagaaacag ggccagagga aaaaaaacta   4980

ttgataagtt tataggcaaa ccaccataag gggtgagtca gacaggtctg atttggttaa   5040

gaatcctaaa tggcatggct ttgacatcaa gctgggtgaa ttagaaaggc atatccagac   5100

cctattaaag aaaccacagg gtttgattct ggttaccagg aagtcttctt tgttcctgtg   5160

ccagaaagaa agttaaaata cttgcttaag aaagggaggg gggtgggagg ggtgtaggga   5220

gagggaaggg agggaaacag ttttgtggga aatattcata tatattttct tctccctttt   5280

tccattttta ggccatgttt taaactcatt ttagtgcatg tatatgaagg gctgggcaga   5340

aaatgaaaaa gcaatacatt ccttgatgca tttgcatgaa ggttgttcaa ctttgtttga   5400

ggtagttgtc cgtttgagtc atgggcaaat gaaggacttt ggtcattttg gacacttaag   5460

taatgtttgg tgtctgtttc ttaggagtga ctgggggagg gaagattatt ttagctattt   5520

atttgtaata ttttaaccct ttatctgttt gtttttatac agtgtttcgt tctaaatcta   5580

tgaggtttag ggttcaaaat gatggaaggc cgaagagcaa ggcttatatg gtggtaggga   5640

gcttatagct tgtgctaata ctgtagcatc aagcccaagc aaattagtca gagcccgcct   5700

ttagagttaa atataataga aaaaccaaaa tgatattttt attttaggag ggtttaaata   5760

gggttcagag atcataggaa tattaggagt tacctctctg tggaggtat               5809


<210>  1064
<211>  1581
<212>  PRT
<213>  Homosapiens

<400>  1064

Met Lys Ala Gln Gly Glu Thr Glu Glu Ser Glu Lys Leu Ser Lys Met 
1               5                   10                  15      


Ser Ser Leu Leu Glu Arg Leu His Ala Lys Phe Asn Gln Asn Arg Pro 
            20                  25                  30          


Trp Ser Glu Thr Ile Lys Leu Val Arg Gln Val Met Glu Lys Arg Val 
        35                  40                  45              


Val Met Ser Ser Gly Gly His Gln His Leu Val Ser Cys Leu Glu Thr 
    50                  55                  60                  


Leu Gln Lys Ala Leu Lys Val Thr Ser Leu Pro Ala Met Thr Asp Arg 
65                  70                  75                  80  


Leu Glu Ser Ile Ala Arg Gln Asn Gly Leu Gly Ser His Leu Ser Ala 
                85                  90                  95      


Ser Gly Thr Glu Cys Tyr Ile Thr Ser Asp Met Phe Tyr Val Glu Val 
            100                 105                 110         


Gln Leu Asp Pro Ala Gly Gln Leu Cys Asp Val Lys Val Ala His His 
        115                 120                 125             


Gly Glu Asn Pro Val Ser Cys Pro Glu Leu Val Gln Gln Leu Arg Glu 
    130                 135                 140                 


Lys Asn Phe Asp Glu Phe Ser Lys His Leu Lys Gly Leu Val Asn Leu 
145                 150                 155                 160 


Tyr Asn Leu Pro Gly Asp Asn Lys Leu Lys Thr Lys Met Tyr Leu Ala 
                165                 170                 175     


Leu Gln Ser Leu Glu Gln Asp Leu Ser Lys Met Ala Ile Met Tyr Trp 
            180                 185                 190         


Lys Ala Thr Asn Ala Gly Pro Leu Asp Lys Ile Leu His Gly Ser Val 
        195                 200                 205             


Gly Tyr Leu Thr Pro Arg Ser Gly Gly His Leu Met Asn Leu Lys Tyr 
    210                 215                 220                 


Tyr Val Ser Pro Ser Asp Leu Leu Asp Asp Lys Thr Ala Ser Pro Ile 
225                 230                 235                 240 


Ile Leu His Glu Asn Asn Val Ser Arg Ser Leu Gly Met Asn Ala Ser 
                245                 250                 255     


Val Thr Ile Glu Gly Thr Ser Ala Val Tyr Lys Leu Pro Ile Ala Pro 
            260                 265                 270         


Leu Ile Met Gly Ser His Pro Val Asp Asn Lys Trp Thr Pro Ser Phe 
        275                 280                 285             


Ser Ser Ile Thr Ser Ala Asn Ser Val Asp Leu Pro Ala Cys Phe Phe 
    290                 295                 300                 


Leu Lys Phe Pro Gln Pro Ile Pro Val Ser Arg Ala Phe Val Gln Lys 
305                 310                 315                 320 


Leu Gln Asn Cys Thr Gly Ile Pro Leu Phe Glu Thr Gln Pro Thr Tyr 
                325                 330                 335     


Ala Pro Leu Tyr Glu Leu Ile Thr Gln Phe Glu Leu Ser Lys Asp Pro 
            340                 345                 350         


Asp Pro Ile Pro Leu Asn His Asn Met Arg Phe Tyr Ala Ala Leu Pro 
        355                 360                 365             


Gly Gln Gln His Cys Tyr Phe Leu Asn Lys Asp Ala Pro Leu Pro Asp 
    370                 375                 380                 


Gly Arg Ser Leu Gln Gly Thr Leu Val Ser Lys Ile Thr Phe Gln His 
385                 390                 395                 400 


Pro Gly Arg Val Pro Leu Ile Leu Asn Leu Ile Arg His Gln Val Ala 
                405                 410                 415     


Tyr Asn Thr Leu Ile Gly Ser Cys Val Lys Arg Thr Ile Leu Lys Glu 
            420                 425                 430         


Asp Ser Pro Gly Leu Leu Gln Phe Glu Val Cys Pro Leu Ser Glu Ser 
        435                 440                 445             


Arg Phe Ser Val Ser Phe Gln His Pro Val Asn Asp Ser Leu Val Cys 
    450                 455                 460                 


Val Val Met Asp Val Gln Asp Ser Thr His Val Ser Cys Lys Leu Tyr 
465                 470                 475                 480 


Lys Gly Leu Ser Asp Ala Leu Ile Cys Thr Asp Asp Phe Ile Ala Lys 
                485                 490                 495     


Val Val Gln Arg Cys Met Ser Ile Pro Val Thr Met Arg Ala Ile Arg 
            500                 505                 510         


Arg Lys Ala Glu Thr Ile Gln Ala Asp Thr Pro Ala Leu Ser Leu Ile 
        515                 520                 525             


Ala Glu Thr Val Glu Asp Met Val Lys Lys Asn Leu Pro Pro Ala Ser 
    530                 535                 540                 


Ser Pro Gly Tyr Gly Met Thr Thr Gly Asn Asn Pro Met Ser Gly Thr 
545                 550                 555                 560 


Thr Thr Pro Thr Asn Thr Phe Pro Gly Gly Pro Ile Thr Thr Leu Phe 
                565                 570                 575     


Asn Met Ser Met Ser Ile Lys Asp Arg His Glu Ser Val Gly His Gly 
            580                 585                 590         


Glu Asp Phe Ser Lys Val Ser Gln Asn Pro Ile Leu Thr Ser Leu Leu 
        595                 600                 605             


Gln Ile Thr Gly Asn Gly Gly Ser Thr Ile Gly Ser Ser Pro Thr Pro 
    610                 615                 620                 


Pro His His Thr Pro Pro Pro Val Ser Ser Met Ala Gly Asn Thr Lys 
625                 630                 635                 640 


Asn His Pro Met Leu Met Asn Leu Leu Lys Asp Asn Pro Ala Gln Asp 
                645                 650                 655     


Phe Ser Thr Leu Tyr Gly Ser Ser Pro Leu Glu Arg Gln Asn Ser Ser 
            660                 665                 670         


Ser Gly Ser Pro Arg Met Glu Ile Cys Ser Gly Ser Asn Lys Thr Lys 
        675                 680                 685             


Lys Lys Lys Ser Ser Arg Leu Pro Pro Glu Lys Pro Lys His Gln Thr 
    690                 695                 700                 


Glu Asp Asp Phe Gln Arg Glu Leu Phe Ser Met Asp Val Asp Ser Gln 
705                 710                 715                 720 


Asn Pro Ile Phe Asp Val Asn Met Thr Ala Asp Thr Leu Asp Thr Pro 
                725                 730                 735     


His Ile Thr Pro Ala Pro Ser Gln Cys Ser Thr Pro Pro Thr Thr Tyr 
            740                 745                 750         


Pro Gln Pro Val Pro His Pro Gln Pro Ser Ile Gln Arg Met Val Arg 
        755                 760                 765             


Leu Ser Ser Ser Asp Ser Ile Gly Pro Asp Val Thr Asp Ile Leu Ser 
    770                 775                 780                 


Asp Ile Ala Glu Glu Ala Ser Lys Leu Pro Ser Thr Ser Asp Asp Cys 
785                 790                 795                 800 


Pro Ala Ile Gly Thr Pro Leu Arg Asp Ser Ser Ser Ser Gly His Ser 
                805                 810                 815     


Gln Ser Thr Leu Phe Asp Ser Asp Val Phe Gln Thr Asn Asn Asn Glu 
            820                 825                 830         


Asn Pro Tyr Thr Asp Pro Ala Asp Leu Ile Ala Asp Ala Ala Gly Ser 
        835                 840                 845             


Pro Ser Ser Asp Ser Pro Thr Asn His Phe Phe His Asp Gly Val Asp 
    850                 855                 860                 


Phe Asn Pro Asp Leu Leu Asn Ser Gln Ser Gln Ser Gly Phe Gly Glu 
865                 870                 875                 880 


Glu Tyr Phe Asp Glu Ser Ser Gln Ser Gly Asp Asn Asp Asp Phe Lys 
                885                 890                 895     


Gly Phe Ala Ser Gln Ala Leu Asn Thr Leu Gly Val Pro Met Leu Gly 
            900                 905                 910         


Gly Asp Asn Gly Glu Thr Lys Phe Lys Gly Asn Asn Gln Ala Asp Thr 
        915                 920                 925             


Val Asp Phe Ser Ile Ile Ser Val Ala Gly Lys Ala Leu Ala Pro Ala 
    930                 935                 940                 


Asp Leu Met Glu His His Ser Gly Ser Gln Gly Pro Leu Leu Thr Thr 
945                 950                 955                 960 


Gly Asp Leu Gly Lys Glu Lys Thr Gln Lys Arg Val Lys Glu Gly Asn 
                965                 970                 975     


Gly Thr Ser Asn Ser Thr Leu Ser Gly Pro Gly Leu Asp Ser Lys Pro 
            980                 985                 990         


Gly Lys Arg Ser Arg Thr Pro Ser  Asn Asp Gly Lys Ser  Lys Asp Lys 
        995                 1000                 1005             


Pro Pro  Lys Arg Lys Lys Ala  Asp Thr Glu Gly Lys  Ser Pro Ser 
    1010                 1015                 1020             


His Ser  Ser Ser Asn Arg Pro  Phe Thr Pro Pro Thr  Ser Thr Gly 
    1025                 1030                 1035             


Gly Ser  Lys Ser Pro Gly Ser  Ala Gly Arg Ser Gln  Thr Pro Pro 
    1040                 1045                 1050             


Gly Val  Ala Thr Pro Pro Ile  Pro Lys Ile Thr Ile  Gln Ile Pro 
    1055                 1060                 1065             


Lys Gly  Thr Val Met Val Gly  Lys Pro Ser Ser His  Ser Gln Tyr 
    1070                 1075                 1080             


Thr Ser  Ser Gly Ser Val Ser  Ser Ser Gly Ser Lys  Ser His His 
    1085                 1090                 1095             


Ser His  Ser Ser Ser Ser Ser  Ser Ser Ala Ser Thr  Ser Gly Lys 
    1100                 1105                 1110             


Met Lys  Ser Ser Lys Ser Glu  Gly Ser Ser Ser Ser  Lys Leu Ser 
    1115                 1120                 1125             


Ser Ser  Met Tyr Ser Ser Gln  Gly Ser Ser Gly Ser  Ser Gln Ser 
    1130                 1135                 1140             


Lys Asn  Ser Ser Gln Ser Gly  Gly Lys Pro Gly Ser  Ser Pro Ile 
    1145                 1150                 1155             


Thr Lys  His Gly Leu Ser Ser  Gly Ser Ser Ser Thr  Lys Met Lys 
    1160                 1165                 1170             


Pro Gln  Gly Lys Pro Ser Ser  Leu Met Asn Pro Ser  Leu Ser Lys 
    1175                 1180                 1185             


Pro Asn  Ile Ser Pro Ser His  Ser Arg Pro Pro Gly  Gly Ser Asp 
    1190                 1195                 1200             


Lys Leu  Ala Ser Pro Met Lys  Pro Val Pro Gly Thr  Pro Pro Ser 
    1205                 1210                 1215             


Ser Lys  Ala Lys Ser Pro Ile  Ser Ser Gly Ser Gly  Gly Ser His 
    1220                 1225                 1230             


Met Ser  Gly Thr Ser Ser Ser  Ser Gly Met Lys Ser  Ser Ser Gly 
    1235                 1240                 1245             


Leu Gly  Ser Ser Gly Ser Leu  Ser Gln Lys Thr Pro  Pro Ser Ser 
    1250                 1255                 1260             


Asn Ser  Cys Thr Ala Ser Ser  Ser Ser Phe Ser Ser  Ser Gly Ser 
    1265                 1270                 1275             


Ser Met  Ser Ser Ser Gln Asn  Gln His Gly Ser Ser  Lys Gly Lys 
    1280                 1285                 1290             


Ser Pro  Ser Arg Asn Lys Lys  Pro Ser Leu Thr Ala  Val Ile Asp 
    1295                 1300                 1305             


Lys Leu  Lys His Gly Val Val  Thr Ser Gly Pro Gly  Gly Glu Asp 
    1310                 1315                 1320             


Pro Leu  Asp Gly Gln Met Gly  Val Ser Thr Asn Ser  Ser Ser His 
    1325                 1330                 1335             


Pro Met  Ser Ser Lys His Asn  Met Ser Gly Gly Glu  Phe Gln Gly 
    1340                 1345                 1350             


Lys Arg  Glu Lys Ser Asp Lys  Asp Lys Ser Lys Val  Ser Thr Ser 
    1355                 1360                 1365             


Gly Ser  Ser Val Asp Ser Ser  Lys Lys Thr Ser Glu  Ser Lys Asn 
    1370                 1375                 1380             


Val Gly  Ser Thr Gly Val Ala  Lys Ile Ile Ile Ser  Lys His Asp 
    1385                 1390                 1395             


Gly Gly  Ser Pro Ser Ile Lys  Ala Lys Val Thr Leu  Gln Lys Pro 
    1400                 1405                 1410             


Gly Glu  Ser Ser Gly Glu Gly  Leu Arg Pro Gln Met  Ala Ser Ser 
    1415                 1420                 1425             


Lys Asn  Tyr Gly Ser Pro Leu  Ile Ser Gly Ser Thr  Pro Lys His 
    1430                 1435                 1440             


Glu Arg  Gly Ser Pro Ser His  Ser Lys Ser Pro Ala  Tyr Thr Pro 
    1445                 1450                 1455             


Gln Asn  Leu Asp Ser Glu Ser  Glu Ser Gly Ser Ser  Ile Ala Glu 
    1460                 1465                 1470             


Lys Ser  Tyr Gln Asn Ser Pro  Ser Ser Asp Asp Gly  Ile Arg Pro 
    1475                 1480                 1485             


Leu Pro  Glu Tyr Ser Thr Glu  Lys His Lys Lys His  Lys Lys Glu 
    1490                 1495                 1500             


Lys Lys  Lys Val Lys Asp Lys  Asp Arg Asp Arg Asp  Arg Asp Lys 
    1505                 1510                 1515             


Asp Arg  Asp Lys Lys Lys Ser  His Ser Ile Lys Pro  Glu Ser Trp 
    1520                 1525                 1530             


Ser Lys  Ser Pro Ile Ser Ser  Asp Gln Ser Leu Ser  Met Thr Ser 
    1535                 1540                 1545             


Asn Thr  Ile Leu Ser Ala Asp  Arg Pro Ser Arg Leu  Ser Pro Asp 
    1550                 1555                 1560             


Phe Met  Ile Gly Glu Glu Asp  Asp Asp Leu Met Asp  Val Ala Leu 
    1565                 1570                 1575             


Ile Gly  Asn 
    1580     


<210>  1065
<211>  5515
<212>  DNA
<213>  Homosapiens

<400>  1065
cttttttccc ttcttcaggt caggggaaag ggaatgccca attcagagag acatgggggc     60

aagaaggacg ggagtggagg agcttctgga actttgcagc cgtcatcggg aggcggcagc    120

tctaacagca gagagcgtca ccgcttggta tcgaagcaca agcggcataa gtccaaacac    180

tccaaagaca tggggttggt gacccccgaa gcagcatccc tgggcacagt tatcaaacct    240

ttggtggagt atgatgatat cagctctgat tccgacacct tctccgatga catggccttc    300

aaactagacc gaagggagaa cgacgaacgt cgtggatcag atcggagcga ccgcctgcac    360

aaacatcgtc accaccagca caggcgttcc cgggacttac taaaagctaa acagaccgaa    420

aaagaaaaaa gccaagaagt ctccagcaag tcgggatcga tgaaggaccg gatatcggga    480

agttcaaagc gttcgaatga ggagactgat gactatggga aggcgcaggt agccaaaagc    540

agcagcaagg aatccaggtc atccaagctc cacaaggaga agaccaggaa agaacgggag    600

ctgaagtctg ggcacaaaga ccggagtaaa agtcatcgaa aaagggaaac acccaaaagt    660

tacaaaacag tggacagccc aaaacggaga tccaggagcc cccacaggaa gtggtctgac    720

agctccaaac aagatgatag cccctcggga gcttcttatg gccaagatta tgaccttagt    780

ccctcacgat ctcatacctc gagcaattat gactcctaca agaaaagtcc tggaagtacc    840

tcgagaaggc agtcggtcag tcccccttac aaggagcctt cggcctacca gtccagcacc    900

cggtcaccga gcccctacag taggcgacag agatctgtca gtccctatag caggagacgg    960

tcgtccagct acgaaagaag tggctcttac agcgggcgat cgcccagtcc ctatggtcga   1020

aggcggtcca gcagcccttt cctgagcaag cggtctctga gtcggagtcc actccccagt   1080

aggaaatcca tgaagtccag aagtagaagt cctgcatatt caagacattc atcttctcat   1140

agtaaaaaga agagatccag ttcacgcagt cgtcattcca gtatctcacc tgtcaggctt   1200

ccacttaatt ccagtctggg agctgaactc agtaggaaaa agaaggaaag agcagctgct   1260

gctgctgcag caaagatgga tggaaaggag tccaagggtt cacctgtatt tttgcctaga   1320

aaagagaaca gttcagtaga ggctaaggat tcaggtttgg agtctaaaaa gttacccaga   1380

agtgtaaaat tggaaaaatc tgccccagat actgaactgg tgaatgtaac acatctaaac   1440

acagaggtaa aaaattcttc agatacaggg aaagtaaagt tggatgagaa ctccgagaag   1500

catcttgtta aagatttgaa agcacaggga acaagagact ctaaacccat agcactgaaa   1560

gaggagattg ttactccaaa ggagacagaa acatcagaaa aggagacccc tccacctctt   1620

cccacaattg cttctccccc accccctcta ccaactacta cccctccacc tcagacaccc   1680

cctttgccac ctttgcctcc aataccagct cttccacagc aaccacctct gcctccttct   1740

cagccagcat ttagtcaggt tcctgcttcc agtacttcaa ctttgccccc ttctactcac   1800

tcaaagacat ctgctgtgtc ctctcaggca aattctcagc cccctgtaca ggtttctgtg   1860

aagactcaag tatctgtaac agctgctatt ccacacctga aaacttcaac gttgcctcct   1920

ttgcccctcc cacccttatt acctggaggt gatgacatgg atagtccaaa agaaactctt   1980

ccttcaaaac ctgtgaagaa agagaaggaa cagaggacac gtcacttact cacagacctt   2040

cctctccctc cagagctccc tggtggagat ctgtctcccc cagactctcc agaaccaaag   2100

gcaatcacac cacctcagca accatataaa aagagaccaa aaatttgttg tcctcgttat   2160

ggagaaagaa gacaaacaga aagcgactgg gggaaacgct gtgtggacaa gtttgacatt   2220

attgggatta ttggagaagg aacctatggc caagtatata aagccaggga caaagacaca   2280

ggagaactag tggctctgaa gaaggtgaga ctagacaatg agaaagaggg cttcccaatc   2340

acagccattc gtgaaatcaa aatccttcgt cagttaatcc accgaagtgt tgttaacatg   2400

aaggaaattg tcacagataa acaagatgca ctggatttca agaaggacaa aggtgccttt   2460

taccttgtat ttgagtatat ggaccatgac ttaatgggac tgctagaatc tggtttggtg   2520

cacttttctg aggaccatat caagtcgttc atgaaacagc taatggaagg attggaatac   2580

tgtcacaaaa agaatttcct gcatcgggat attaagtgtt ctaacatttt gctgaataac   2640

agtgggcaaa tcaaactagc agattttgga cttgctcggc tctataactc tgaagagagt   2700

cgcccttaca caaacaaagt cattactttg tggtaccgac ctccagaact actgctagga   2760

gaggaacgtt acacaccagc catagatgtt tggagctgtg gatgtattct tggggaacta   2820

ttcacaaaga agcctatttt tcaagccaat ctggaactgg ctcagctaga actgatcagc   2880

cgactttgtg gtagcccttg tccagctgtg tggcctgatg ttatcaaact gccctacttc   2940

aacaccatga aaccgaagaa gcaatatcga aggcgtctac gagaagaatt ctctttcatt   3000

ccttctgcag cacttgattt attggaccac atgctgacac tagatcctag taagcggtgc   3060

acagctgaac agaccctaca gagcgacttc cttaaagatg tcgaactcag caaaatggct   3120

cctccagacc tcccccactg gcaggattgc catgagttgt ggagtaagaa acggcgacgt   3180

cagcgacaaa gtggtgttgt agtcgaagag ccacctccat ccaaaacttc tcgaaaagaa   3240

actacctcag ggacaagtac tgagcctgtg aagaacagca gcccagcacc acctcagcct   3300

gctcctggca aggtggagtc tggggctggg gatgcaatag gccttgctga catcacacaa   3360

cagctgaatc aaagtgaatt ggcagtgtta ttaaacctgc tgcagagcca aaccgacctg   3420

agcatccctc aaatggcaca gctgcttaac atccactcca acccagagat gcagcagcag   3480

ctggaagccc tgaaccaatc catcagtgcc ctgacggaag ctacttccca gcagcaggac   3540

tcagagacca tggccccaga ggagtctttg aaggaagcac cctctgcccc agtgatcctg   3600

ccttcagcag aacagatgac ccttgaagct tcaagcacac cagctgacat gcagaatata   3660

ttggcagttc tcttgagtca gctgatgaaa acccaagagc cagcaggcag tctggaggaa   3720

aacaacagtg acaagaacag tgggccacag gggccccgaa gaactcccac aatgccacag   3780

gaggaggcag cagcatgtcc tcctcacatt cttccaccag agaagaggcc ccctgagccc   3840

cccggacctc caccgccgcc acctccaccc cctctggttg aaggcgatct ttccagcgcc   3900

ccccaggagt tgaacccagc cgtgacagcc gccttgctgc aacttttatc ccagcctgaa   3960

gcagagcctc ctggccacct gccacatgag caccaggcct tgagaccaat ggagtactcc   4020

acccgacccc gtccaaacag gacttatgga aacactgatg ggcctgaaac agggttcagt   4080

gccattgaca ctgatgaacg aaactctggt ccagccttga cagaatcctt ggtccagacc   4140

ctggtgaaga acaggacctt ctcaggctct ctgagccacc ttggggagtc cagcagttac   4200

cagggcacag ggtcagtgca gtttccaggg gaccaggacc tccgttttgc cagggtcccc   4260

ttagcgttac acccggtggt cgggcaacca ttcctgaagg ctgagggaag cagcaattct   4320

gtggtacatg cagagaccaa attgcaaaac tatggggagc tggggccagg aaccactggg   4380

gccagcagct caggagcagg ccttcactgg gggggcccaa ctcagtcttc tgcttatgga   4440

aaactctatc gggggcctac aagagtccca ccaagagggg gaagagggag aggagttcct   4500

tactaaccca gagacttcag tgtcctgaaa gattcctttc ctatccatcc ttccatccag   4560

ttctctgaat ctttaatgaa atcatttgcc agagcgaggt aatcatctgc atttggctac   4620

tgcaaagctg tccgttgtat tccttgctca cttgctacta gcaggcgact taggaaataa   4680

tgatgttggc accagttccc cctggatggg ctatagccag aacatttact tcaactctac   4740

cttagtagat acaagtagag aatatggaga ggatcattac attgaaaagt aaatgtttta   4800

ttagttcatt gcctgcactt actggtcgga agagagaaag aacagtttca gtattgagat   4860

ggctcaggag aggctctttg atttttaaag ttttggggtg gggggttgtg tgtggtttct   4920

ttcttttgaa ttttaattta ggtgttttgg gtttttttcc tttaaagaga atagtgttca   4980

caaaatttga gctgctcttt ggcttttgct ataagggaaa cagagtggcc tggctgattt   5040

gaataaatgt ttctttcctc tccaccatct cacattttgc ttttaagtga acactttttc   5100

cccattgagc atcttgaaca tacttttttt ccaaataaat tactcatcct taaagtttac   5160

tccactttga caaaagatac gcccttctcc ctgcacataa agcaggttgt agaacgtggc   5220

attcttgggc aagtaggtag actttaccca gtctctttcc ttttttgctg atgtgtgctc   5280

tctctctctc tttctctctc tctctctctc tctctctctc tctgtctgtc tcgcttgctc   5340

gctctcgctg tttctctctc tttgaggcat ttgtttggaa aaaatcgttg agatgcccaa   5400

gaacctggga taattcttta ctttttttga aataaaggaa aggaaattca aaaaaaaaaa   5460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        5515


<210>  1066
<211>  1490
<212>  PRT
<213>  Homosapiens

<400>  1066

Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly 
1               5                   10                  15      


Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser 
            20                  25                  30          


Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys 
        35                  40                  45              


His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly 
    50                  55                  60                  


Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser 
65                  70                  75                  80  


Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn 
                85                  90                  95      


Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg 
            100                 105                 110         


His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr 
        115                 120                 125             


Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys 
    130                 135                 140                 


Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp 
145                 150                 155                 160 


Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser 
                165                 170                 175     


Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser 
            180                 185                 190         


Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys 
        195                 200                 205             


Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His 
    210                 215                 220                 


Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala 
225                 230                 235                 240 


Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser 
                245                 250                 255     


Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg 
            260                 265                 270         


Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser 
        275                 280                 285             


Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro 
    290                 295                 300                 


Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser 
305                 310                 315                 320 


Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe 
                325                 330                 335     


Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser 
            340                 345                 350         


Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser 
        355                 360                 365             


His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile 
    370                 375                 380                 


Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser 
385                 390                 395                 400 


Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp 
                405                 410                 415     


Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn 
            420                 425                 430         


Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro 
        435                 440                 445             


Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn 
    450                 455                 460                 


Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys 
465                 470                 475                 480 


Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys 
                485                 490                 495     


Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile 
            500                 505                 510         


Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro 
        515                 520                 525             


Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro 
    530                 535                 540                 


Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu 
545                 550                 555                 560 


Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val 
                565                 570                 575     


Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr 
            580                 585                 590         


Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser 
        595                 600                 605             


Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr 
    610                 615                 620                 


Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Gly Asp 
625                 630                 635                 640 


Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys 
                645                 650                 655     


Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro 
            660                 665                 670         


Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro 
        675                 680                 685             


Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile 
    690                 695                 700                 


Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly 
705                 710                 715                 720 


Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly 
                725                 730                 735     


Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp Thr Gly Glu Leu 
            740                 745                 750         


Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro 
        755                 760                 765             


Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg 
    770                 775                 780                 


Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu 
785                 790                 795                 800 


Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met 
                805                 810                 815     


Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser 
            820                 825                 830         


Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu 
        835                 840                 845             


Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn 
    850                 855                 860                 


Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu 
865                 870                 875                 880 


Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val 
                885                 890                 895     


Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg 
            900                 905                 910         


Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu 
        915                 920                 925             


Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln 
    930                 935                 940                 


Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp 
945                 950                 955                 960 


Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys 
                965                 970                 975     


Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala 
            980                 985                 990         


Ala Leu Asp Leu Leu Asp His Met  Leu Thr Leu Asp Pro  Ser Lys Arg 
        995                 1000                 1005             


Cys Thr  Ala Glu Gln Thr Leu  Gln Ser Asp Phe Leu  Lys Asp Val 
    1010                 1015                 1020             


Glu Leu  Ser Lys Met Ala Pro  Pro Asp Leu Pro His  Trp Gln Asp 
    1025                 1030                 1035             


Cys His  Glu Leu Trp Ser Lys  Lys Arg Arg Arg Gln  Arg Gln Ser 
    1040                 1045                 1050             


Gly Val  Val Val Glu Glu Pro  Pro Pro Ser Lys Thr  Ser Arg Lys 
    1055                 1060                 1065             


Glu Thr  Thr Ser Gly Thr Ser  Thr Glu Pro Val Lys  Asn Ser Ser 
    1070                 1075                 1080             


Pro Ala  Pro Pro Gln Pro Ala  Pro Gly Lys Val Glu  Ser Gly Ala 
    1085                 1090                 1095             


Gly Asp  Ala Ile Gly Leu Ala  Asp Ile Thr Gln Gln  Leu Asn Gln 
    1100                 1105                 1110             


Ser Glu  Leu Ala Val Leu Leu  Asn Leu Leu Gln Ser  Gln Thr Asp 
    1115                 1120                 1125             


Leu Ser  Ile Pro Gln Met Ala  Gln Leu Leu Asn Ile  His Ser Asn 
    1130                 1135                 1140             


Pro Glu  Met Gln Gln Gln Leu  Glu Ala Leu Asn Gln  Ser Ile Ser 
    1145                 1150                 1155             


Ala Leu  Thr Glu Ala Thr Ser  Gln Gln Gln Asp Ser  Glu Thr Met 
    1160                 1165                 1170             


Ala Pro  Glu Glu Ser Leu Lys  Glu Ala Pro Ser Ala  Pro Val Ile 
    1175                 1180                 1185             


Leu Pro  Ser Ala Glu Gln Met  Thr Leu Glu Ala Ser  Ser Thr Pro 
    1190                 1195                 1200             


Ala Asp  Met Gln Asn Ile Leu  Ala Val Leu Leu Ser  Gln Leu Met 
    1205                 1210                 1215             


Lys Thr  Gln Glu Pro Ala Gly  Ser Leu Glu Glu Asn  Asn Ser Asp 
    1220                 1225                 1230             


Lys Asn  Ser Gly Pro Gln Gly  Pro Arg Arg Thr Pro  Thr Met Pro 
    1235                 1240                 1245             


Gln Glu  Glu Ala Ala Ala Cys  Pro Pro His Ile Leu  Pro Pro Glu 
    1250                 1255                 1260             


Lys Arg  Pro Pro Glu Pro Pro  Gly Pro Pro Pro Pro  Pro Pro Pro 
    1265                 1270                 1275             


Pro Pro  Leu Val Glu Gly Asp  Leu Ser Ser Ala Pro  Gln Glu Leu 
    1280                 1285                 1290             


Asn Pro  Ala Val Thr Ala Ala  Leu Leu Gln Leu Leu  Ser Gln Pro 
    1295                 1300                 1305             


Glu Ala  Glu Pro Pro Gly His  Leu Pro His Glu His  Gln Ala Leu 
    1310                 1315                 1320             


Arg Pro  Met Glu Tyr Ser Thr  Arg Pro Arg Pro Asn  Arg Thr Tyr 
    1325                 1330                 1335             


Gly Asn  Thr Asp Gly Pro Glu  Thr Gly Phe Ser Ala  Ile Asp Thr 
    1340                 1345                 1350             


Asp Glu  Arg Asn Ser Gly Pro  Ala Leu Thr Glu Ser  Leu Val Gln 
    1355                 1360                 1365             


Thr Leu  Val Lys Asn Arg Thr  Phe Ser Gly Ser Leu  Ser His Leu 
    1370                 1375                 1380             


Gly Glu  Ser Ser Ser Tyr Gln  Gly Thr Gly Ser Val  Gln Phe Pro 
    1385                 1390                 1395             


Gly Asp  Gln Asp Leu Arg Phe  Ala Arg Val Pro Leu  Ala Leu His 
    1400                 1405                 1410             


Pro Val  Val Gly Gln Pro Phe  Leu Lys Ala Glu Gly  Ser Ser Asn 
    1415                 1420                 1425             


Ser Val  Val His Ala Glu Thr  Lys Leu Gln Asn Tyr  Gly Glu Leu 
    1430                 1435                 1440             


Gly Pro  Gly Thr Thr Gly Ala  Ser Ser Ser Gly Ala  Gly Leu His 
    1445                 1450                 1455             


Trp Gly  Gly Pro Thr Gln Ser  Ser Ala Tyr Gly Lys  Leu Tyr Arg 
    1460                 1465                 1470             


Gly Pro  Thr Arg Val Pro Pro  Arg Gly Gly Arg Gly  Arg Gly Val 
    1475                 1480                 1485             


Pro Tyr  
    1490 


<210>  1067
<211>  2019
<212>  DNA
<213>  Homosapiens

<400>  1067
agagatgcca cactcgctcc gcggttcgca tggcgctctg aagacgccgg cgcccgccgc     60

cttgaggagc cgctgccccc gctccctgaa gatgggggaa caatgaaata agcgagaaga    120

tccctcttct cccccctctc tctcttgccc cctccccccc tcccctcccc tctccccttg    180

actcctctcc gaggcaccat gctgacccgc ctgttcagcg agcccggcct tctctcggac    240

gtgcccaagt tcgccagctg gggcgacggc gaagacgacg agccgaggag cgacaagggc    300

gacgcgccgc caccgccacc gcctgcgccc gggccagggg ctccggggcc agcccgggcg    360

gccaagccag tccctctccg tggagaagag gggacggagg ccacgttggc cgaggtcaag    420

gaggaaggcg agctgggggg agaggaggag gaggaagagg aggaggaaga aggactggac    480

gaggcggagg gcgagcggcc caagaagggc gggcccaaga agcgcaagat gaccaaggcg    540

cgcttggagc gctccaagct tcggcggcag aaggcgaacg cgcgggagcg caaccgcatg    600

cacgacctga acgcagccct ggacaacctg cgcaaggtgg tgccctgcta ctccaagacg    660

cagaagctgt ccaagatcga gacgctgcgc ctagccaaga actatatctg ggcgctctcg    720

gagatcctgc gctccggcaa gcggccagac ctagtgtcct acgtgcagac tctgtgcaag    780

ggtctgtcgc agcccaccac caatctggtg gccggctgtc tgcagctcaa ctctcgcaac    840

ttcctcacgg agcaaggcgc cgacggtgcc ggccgcttcc acggctcggg cggcccgttc    900

gccatgcacc cctacccgta cccgtgctcg cgcctggcgg gcgcacagtg ccaggcggcc    960

ggcggcctgg gcggcggcgc ggcgcacgcc ctgcggaccc acggctactg cgcagcctac   1020

gagacgctgt atgcggcggc aggcggtggc ggcgcgagcc cggactacaa cagctccgag   1080

tacgagggcc cgctcagccc cccgctctgt ctcaatggca acttctcact caagcaggac   1140

tcctcgcccg accacgagaa aagctaccac tactctatgc actactcggc gctgcccggt   1200

tcgcggccca cgggccacgg gctagtcttc ggctcgtcgg ctgtgcgcgg gggcgtccac   1260

tcggagaatc tcttgtctta cgatatgcac cttcaccacg accggggccc catgtacgag   1320

gagctcaatg cgttttttca taactgagac ttcgcgccgg ctcccttctt tttcttttgc   1380

ctttgcccgc cccccctgtc cccagccccc agagcgcagg gacaccccca tcctaccccg   1440

gcgccgggcg cggggagcgg gccaccggtc ctgccgctct cctggggcag cgcagtcctg   1500

ttacctgtgg gtggcctgtc ccaggggcct cgcttccccc aggggactcg ccttctctct   1560

ccgcaagggg ttccctcctc ctctctccca aggagtgctt ctccagggac ctctctccgg   1620

gggctccctg gaggcacccc tcccccattc ccaatatctt cgctgaggtt tcctcctccc   1680

cctcctccct gcaggcccaa ggcgttggta agggggcagc tgagcaatgg aacgcgtttc   1740

cccctctcat tattatttta aaaacagaca cccagctgcc gaggcaaaaa ggagccaggc   1800

gctccctctt tcttgaagag ggtagaagtt agggcgccgg agcccgggcc tggaacgccc   1860

tcacccccaa cctccagtct ccgcgttttg cgattttaat tttggcggga ggggaagtgg   1920

attgagagga aagagagagg ccaagacaat ttgtaactag aatccgtttt tcccttttcc   1980

tttttttaaa caaacaaaca tacaaaaaaa aaaaaaaaa                          2019


<210>  1068
<211>  382
<212>  PRT
<213>  Homosapiens

<400>  1068

Met Leu Thr Arg Leu Phe Ser Glu Pro Gly Leu Leu Ser Asp Val Pro 
1               5                   10                  15      


Lys Phe Ala Ser Trp Gly Asp Gly Glu Asp Asp Glu Pro Arg Ser Asp 
            20                  25                  30          


Lys Gly Asp Ala Pro Pro Pro Pro Pro Pro Ala Pro Gly Pro Gly Ala 
        35                  40                  45              


Pro Gly Pro Ala Arg Ala Ala Lys Pro Val Pro Leu Arg Gly Glu Glu 
    50                  55                  60                  


Gly Thr Glu Ala Thr Leu Ala Glu Val Lys Glu Glu Gly Glu Leu Gly 
65                  70                  75                  80  


Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Leu Asp Glu Ala 
                85                  90                  95      


Glu Gly Glu Arg Pro Lys Lys Gly Gly Pro Lys Lys Arg Lys Met Thr 
            100                 105                 110         


Lys Ala Arg Leu Glu Arg Ser Lys Leu Arg Arg Gln Lys Ala Asn Ala 
        115                 120                 125             


Arg Glu Arg Asn Arg Met His Asp Leu Asn Ala Ala Leu Asp Asn Leu 
    130                 135                 140                 


Arg Lys Val Val Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile 
145                 150                 155                 160 


Glu Thr Leu Arg Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile 
                165                 170                 175     


Leu Arg Ser Gly Lys Arg Pro Asp Leu Val Ser Tyr Val Gln Thr Leu 
            180                 185                 190         


Cys Lys Gly Leu Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu 
        195                 200                 205             


Gln Leu Asn Ser Arg Asn Phe Leu Thr Glu Gln Gly Ala Asp Gly Ala 
    210                 215                 220                 


Gly Arg Phe His Gly Ser Gly Gly Pro Phe Ala Met His Pro Tyr Pro 
225                 230                 235                 240 


Tyr Pro Cys Ser Arg Leu Ala Gly Ala Gln Cys Gln Ala Ala Gly Gly 
                245                 250                 255     


Leu Gly Gly Gly Ala Ala His Ala Leu Arg Thr His Gly Tyr Cys Ala 
            260                 265                 270         


Ala Tyr Glu Thr Leu Tyr Ala Ala Ala Gly Gly Gly Gly Ala Ser Pro 
        275                 280                 285             


Asp Tyr Asn Ser Ser Glu Tyr Glu Gly Pro Leu Ser Pro Pro Leu Cys 
    290                 295                 300                 


Leu Asn Gly Asn Phe Ser Leu Lys Gln Asp Ser Ser Pro Asp His Glu 
305                 310                 315                 320 


Lys Ser Tyr His Tyr Ser Met His Tyr Ser Ala Leu Pro Gly Ser Arg 
                325                 330                 335     


Pro Thr Gly His Gly Leu Val Phe Gly Ser Ser Ala Val Arg Gly Gly 
            340                 345                 350         


Val His Ser Glu Asn Leu Leu Ser Tyr Asp Met His Leu His His Asp 
        355                 360                 365             


Arg Gly Pro Met Tyr Glu Glu Leu Asn Ala Phe Phe His Asn 
    370                 375                 380         


<210>  1069
<211>  1841
<212>  DNA
<213>  Homosapiens

<400>  1069
agctgggacc ggagggtgag cccggcagag gcagagacac acgcggagag gaggagaggc     60

tgagggaggg aggtggagaa ggacgggaga ggcagagaga ggagacacgc agagacactc    120

aggaggggag agacaccgag acgcagagac actcaggagg ggagagacac cgagacgcag    180

agacacccag gccggggagc gcgagggagc gaggcacaga cctggctcag cgagcgcggg    240

gggcgagccc cgagtcccga gagcctgggg gcgcgcccag cccgggcgcc gaccctcctc    300

ccgctcccgc gccctcccct cggcgggcac ggtattttta tccgtgcgcg aacagccctc    360

ctcctcctct cgccgcacag cccgccgcct gcgcggggga gcccagcaca gaccgccgcc    420

gggaccccga gtcgcgcacc ccagccccac cgcccacccc gcgcgccatg gaccccaagg    480

accgcaagaa gatccagttc tcggtgcccg cgccccctag ccagctcgac ccccgccagg    540

tggagatgat ccggcgcagg agaccaacgc ctgccatgct gttccggctc tcagagcact    600

cctcaccaga ggaggaagcc tccccccacc agagagcctc aggagagggg caccatctca    660

agtcgaagag acccaacccc tgtgcctaca caccaccttc gctgaaagct gtgcagcgca    720

ttgctgagtc tcacctgcag tctatcagca atttgaatga gaaccaggcc tcagaggagg    780

aggatgagct gggggagctt cgggagctgg gttatccaag agaggaagat gaggaggaag    840

aggaggatga tgaagaagag gaagaagaag aggacagcca ggctgaagtc ctgaaggtca    900

tcaggcagtc tgctgggcaa aagacaacct gtggccaggg tctggaaggg ccctgggagc    960

gcccaccccc tctggatgag tccgagagag atggaggctc tgaggaccaa gtggaagacc   1020

cagcactaag tgagcctggg gaggaacctc agcgcccttc cccctctgag cctggcacat   1080

aggcacccag cctgcatctc ccaggaggaa gtggagggga catcgctgtt ccccagaaac   1140

ccactctatc ctcaccctgt tttgtgctct tcccctcgcc tgctagggct gcggcttctg   1200

acttctagaa gactaaggct ggtctgtgtt tgcttgtttg cccacctttg gctgataccc   1260

agagaacctg ggcacttgct gcctgatgcc cacccctgcc agtcattcct ccattcaccc   1320

agcgggaggt gggatgtgag acagcccaca ttggaaaatc cagaaaaccg ggaacaggga   1380

tttgcccttc acaattctac tccccagatc ctctcccctg gacacaggag acccacaggg   1440

caggacccta agatctgggg aaaggaggtc ctgagaacct tgaggtaccc ttagatcctt   1500

ttctacccac tttcctatgg aggattccaa gtcaccactt ctctcaccgg cttctaccag   1560

ggtccaggac taaggcgttt ttctccatag cctcaacatt ttgggaatct tcccttaatc   1620

acccttgctc ctcctgggtg cctggaagat ggactggcag agacctcttt gttgcgtttt   1680

gtgctttgat gccaggaatg ccgcctagtt tatgtccccg gtggggcaca cagcgggggg   1740

cgccaggttt tccttgtccc ccagctgctc tgcccctttc cccttcttcc ctgactccag   1800

gcctgaaccc ctcccgtgct gtaataaatc tttgtaaata a                       1841


<210>  1070
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  1070

Met Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro 
1               5                   10                  15      


Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu 
        35                  40                  45              


Glu Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu 
    50                  55                  60                  


Lys Ser Lys Arg Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys 
65                  70                  75                  80  


Ala Val Gln Arg Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu 
                85                  90                  95      


Asn Glu Asn Gln Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg 
            100                 105                 110         


Glu Leu Gly Tyr Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val 
    130                 135                 140                 


Ile Arg Gln Ser Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Trp Glu Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly 
                165                 170                 175     


Gly Ser Glu Asp Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu 
            180                 185                 190         


Glu Pro Gln Arg Pro Ser Pro Ser Glu Pro Gly Thr 
        195                 200                 


<210>  1071
<211>  1529
<212>  DNA
<213>  Homosapiens

<400>  1071
attcacttct cacaaggact gggtgaagag ttctgcagcc ttacagagac tggaaaagaa     60

gcccaaacca aggcccccag agaggtcccc caggcccctt tgggtccctg agcctcagct    120

ggaggtgggg ggtgcctgca gtgcgctggc tcagtctcct tctgaaaagc tggatccagc    180

ttgtttgaag cccttgagct gatcttagat ccggcgcagg agaccaacgc ctgccatgct    240

gttccggctc tcagagcact cctcaccaga ggaggaagcc tccccccacc agagagcctc    300

aggagagggg caccatctca agtcgaagag acccaacccc tgtgcctaca caccaccttc    360

gctgaaagct gtgcagcgca ttgctgagtc tcacctgcag tctatcagca atttgaatga    420

gaaccaggcc tcagaggagg aggatgagct gggggagctt cgggagctgg gttatccaag    480

agaggaagat gaggaggaag aggaggatga tgaagaagag gaagaagaag aggacagcca    540

ggctgaagtc ctgaaggtca tcaggcagtc tgctgggcaa aagacaacct gtggccaggg    600

tctggaaggg ccctgggagc gcccaccccc tctggatgag tccgagagag atggaggctc    660

tgaggaccaa gtggaagacc cagcactaag tgagcctggg gaggaacctc agcgcccttc    720

cccctctgag cctggcacat aggcacccag cctgcatctc ccaggaggaa gtggagggga    780

catcgctgtt ccccagaaac ccactctatc ctcaccctgt tttgtgctct tcccctcgcc    840

tgctagggct gcggcttctg acttctagaa gactaaggct ggtctgtgtt tgcttgtttg    900

cccacctttg gctgataccc agagaacctg ggcacttgct gcctgatgcc cacccctgcc    960

agtcattcct ccattcaccc agcgggaggt gggatgtgag acagcccaca ttggaaaatc   1020

cagaaaaccg ggaacaggga tttgcccttc acaattctac tccccagatc ctctcccctg   1080

gacacaggag acccacaggg caggacccta agatctgggg aaaggaggtc ctgagaacct   1140

tgaggtaccc ttagatcctt ttctacccac tttcctatgg aggattccaa gtcaccactt   1200

ctctcaccgg cttctaccag ggtccaggac taaggcgttt ttctccatag cctcaacatt   1260

ttgggaatct tcccttaatc acccttgctc ctcctgggtg cctggaagat ggactggcag   1320

agacctcttt gttgcgtttt gtgctttgat gccaggaatg ccgcctagtt tatgtccccg   1380

gtggggcaca cagcgggggg cgccaggttt tccttgtccc ccagctgctc tgcccctttc   1440

cccttcttcc ctgactccag gcctgaaccc ctcccgtgct gtaataaatc tttgtaaata   1500

acaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     1529


<210>  1072
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  1072

Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu Glu Glu Ala Ser 
1               5                   10                  15      


Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu Lys Ser Lys Arg 
            20                  25                  30          


Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys Ala Val Gln Arg 
        35                  40                  45              


Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu Asn Glu Asn Gln 
    50                  55                  60                  


Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg Glu Leu Gly Tyr 
65                  70                  75                  80  


Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val Ile Arg Gln Ser 
            100                 105                 110         


Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu Gly Pro Trp Glu 
        115                 120                 125             


Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly Gly Ser Glu Asp 
    130                 135                 140                 


Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu Glu Pro Gln Arg 
145                 150                 155                 160 


Pro Ser Pro Ser Glu Pro Gly Thr 
                165             


<210>  1073
<211>  2073
<212>  DNA
<213>  Homosapiens

<400>  1073
ggcgctactg aggccgcgga gccggactgc ggttggggcg ggaagagccg gggccgtggc     60

tgacatggag cagccctgct gctgaggccg cgccctcccc gccctgaggt gggggcccac    120

caggatgagc aagctgccca gggagctgac ccgagacttg gagcgcagcc tgcctgccgt    180

ggcctccctg ggctcctcac tgtcccacag ccagagcctc tcctcgcacc tccttccgcc    240

gcctgagaag cgaagggcca tctctgatgt ccgccgcacc ttctgtctct tcgtcacctt    300

cgacctgctc ttcatctccc tgctctggat catcgaactg aataccaaca caggcatccg    360

taagaacttg gagcaggaga tcatccagta caactttaaa acttccttct tcgacatctt    420

tgtcctggcc ttcttccgct tctctggact gctcctaggc tatgccgtgc tgcggctccg    480

gcactggtgg gtgattgcgg tcacgacgct ggtgtccagt gcattcctca ttgtcaaggt    540

catcctctct gagctgctca gcaaaggggc atttggctac ctgctcccca tcgtctcttt    600

tgtcctcgcc tggttggaga cctggttcct tgacttcaaa gtcctacccc aggaagctga    660

agaggagcga tggtatcttg ccgcccaggt tgctgttgcc cgtggacccc tgctgttctc    720

cggtgctctg tccgagggac agttctattc acccccagaa tcctttgcag cgtctgacaa    780

tgaatcagat gaagaagttg ctgggaagaa aagtttctct gctcaggagc gggagtacat    840

ccgccagggg aaggaggcca cggcagtggt ggaccagatc ttggcccagg aagagaactg    900

gaagtttgag aagaataatg aatatgggga caccgtgtac accattgaag ttccctttca    960

cggcaagacg tttatcctga agaccttcct gccctgtcct gcggagctcg tgtaccagga   1020

ggtgatcctg cagcccgaga ggatggtgct gtggaacaag acagtgactg cctgccagat   1080

cctgcagcga gtggaagaca acaccctcat ctcctatgac gtgtctgcag gggctgcggg   1140

cggcgtggtc tccccaaggg acttcgtgaa tgtccggcgc attgagcggc gcagggaccg   1200

atacttgtca tcagggatcg ccacctcaca cagtgccaag cccccgacgc acaaatatgt   1260

ccggggagag aatggccctg ggggcttcat cgtgctcaag tcggccagta acccccgtgt   1320

ttgcaccttt gtctggattc ttaatacaga tctcaagggc cgcctgcccc ggtacctcat   1380

ccaccagagc ctcgcggcca ccatgtttga atttgccttt cacctgcgac agcgcatcag   1440

cgagctgggg gcccgggcgt gactgtgccc cctcccaccc tgcgggccag ggtcctgtcg   1500

ccaccacttc cagagccaga aagggtgcca gttgggctcg cactgcccac atgggacctg   1560

gccccaggct gtcaccctcc accgagccac gcagtgcctg gagttgactg actgagcagg   1620

ctgtggggtg gagcactgga ctccggggcc ccactggctg gaggaagtgg ggtctggcct   1680

gttgatgttt acatggcgcc ctgcctcctg gaggaccaga ttgctctgcc ccaccttgcc   1740

agggcagggt ctgggctggg cacctgactt ggctggggag gaccagggcc ctgggcaggg   1800

cagggcagcc tgtcacccgt gtgaagatga aggggctctt catctgcctg cgctctcgtc   1860

ggttttttta ggattattga aagagtctgg gacccttgtt ggggagtggg tggcaggtgg   1920

gggtgggctg ctggccatga atctctgcct ctcccaggct gtccccctcc tcccagggcc   1980

tcctggggga cctttgtatt aagccaatta aaaacatgaa tttaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                2073


<210>  1074
<211>  445
<212>  PRT
<213>  Homosapiens

<400>  1074

Met Ser Lys Leu Pro Arg Glu Leu Thr Arg Asp Leu Glu Arg Ser Leu 
1               5                   10                  15      


Pro Ala Val Ala Ser Leu Gly Ser Ser Leu Ser His Ser Gln Ser Leu 
            20                  25                  30          


Ser Ser His Leu Leu Pro Pro Pro Glu Lys Arg Arg Ala Ile Ser Asp 
        35                  40                  45              


Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu Phe Ile 
    50                  55                  60                  


Ser Leu Leu Trp Ile Ile Glu Leu Asn Thr Asn Thr Gly Ile Arg Lys 
65                  70                  75                  80  


Asn Leu Glu Gln Glu Ile Ile Gln Tyr Asn Phe Lys Thr Ser Phe Phe 
                85                  90                  95      


Asp Ile Phe Val Leu Ala Phe Phe Arg Phe Ser Gly Leu Leu Leu Gly 
            100                 105                 110         


Tyr Ala Val Leu Arg Leu Arg His Trp Trp Val Ile Ala Val Thr Thr 
        115                 120                 125             


Leu Val Ser Ser Ala Phe Leu Ile Val Lys Val Ile Leu Ser Glu Leu 
    130                 135                 140                 


Leu Ser Lys Gly Ala Phe Gly Tyr Leu Leu Pro Ile Val Ser Phe Val 
145                 150                 155                 160 


Leu Ala Trp Leu Glu Thr Trp Phe Leu Asp Phe Lys Val Leu Pro Gln 
                165                 170                 175     


Glu Ala Glu Glu Glu Arg Trp Tyr Leu Ala Ala Gln Val Ala Val Ala 
            180                 185                 190         


Arg Gly Pro Leu Leu Phe Ser Gly Ala Leu Ser Glu Gly Gln Phe Tyr 
        195                 200                 205             


Ser Pro Pro Glu Ser Phe Ala Ala Ser Asp Asn Glu Ser Asp Glu Glu 
    210                 215                 220                 


Val Ala Gly Lys Lys Ser Phe Ser Ala Gln Glu Arg Glu Tyr Ile Arg 
225                 230                 235                 240 


Gln Gly Lys Glu Ala Thr Ala Val Val Asp Gln Ile Leu Ala Gln Glu 
                245                 250                 255     


Glu Asn Trp Lys Phe Glu Lys Asn Asn Glu Tyr Gly Asp Thr Val Tyr 
            260                 265                 270         


Thr Ile Glu Val Pro Phe His Gly Lys Thr Phe Ile Leu Lys Thr Phe 
        275                 280                 285             


Leu Pro Cys Pro Ala Glu Leu Val Tyr Gln Glu Val Ile Leu Gln Pro 
    290                 295                 300                 


Glu Arg Met Val Leu Trp Asn Lys Thr Val Thr Ala Cys Gln Ile Leu 
305                 310                 315                 320 


Gln Arg Val Glu Asp Asn Thr Leu Ile Ser Tyr Asp Val Ser Ala Gly 
                325                 330                 335     


Ala Ala Gly Gly Val Val Ser Pro Arg Asp Phe Val Asn Val Arg Arg 
            340                 345                 350         


Ile Glu Arg Arg Arg Asp Arg Tyr Leu Ser Ser Gly Ile Ala Thr Ser 
        355                 360                 365             


His Ser Ala Lys Pro Pro Thr His Lys Tyr Val Arg Gly Glu Asn Gly 
    370                 375                 380                 


Pro Gly Gly Phe Ile Val Leu Lys Ser Ala Ser Asn Pro Arg Val Cys 
385                 390                 395                 400 


Thr Phe Val Trp Ile Leu Asn Thr Asp Leu Lys Gly Arg Leu Pro Arg 
                405                 410                 415     


Tyr Leu Ile His Gln Ser Leu Ala Ala Thr Met Phe Glu Phe Ala Phe 
            420                 425                 430         


His Leu Arg Gln Arg Ile Ser Glu Leu Gly Ala Arg Ala 
        435                 440                 445 


<210>  1075
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  1075
aatgaggagt gatcatggct acctcagagc tgagctgcga ggtgtcggag gagaactgtg     60

agcgccggga ggccttctgg gcagaatgga aggatctgac actgtccaca cggcccgagg    120

agggctgctc cctgcatgag gaggacaccc agagacatga gacctaccac cagcaggggc    180

agtgccaggt gctggtgcag cgctcgccct ggctgatgat gcggatgggc atcctcggcc    240

gtgggctgca ggagtaccag ctgccctacc agcgggtact gccgctgccc atcttcaccc    300

ctgccaagat gggcgccacc aaggaggagc gtgaggacac ccccatccag cttcaggagc    360

tgctggcgct ggagacagcc ctgggtggcc agtgtgtgga ccgccaggag gtggctgaga    420

tcacaaagca gctgccccct gtggtgcctg tcagcaagcc cggtgccctt cgtcgctccc    480

tgtcccgctc catgtcccag gaagcacaga gaggctgaga gggactgtga cttgggctcc    540

gctgtgcccg ccctgggctg ggcccttcct ggctaggact gtggagggga gctgctggcc    600

atggctgctt tgtagtttgc ccagagttgg gggctagggg aggggggagc cagaggccag    660

gatgcctgag ccccctgagt tcccaaaggg agggtggcag agacagtggg cactaagggt    720

ggagagttgg gggccagcac agctgaggac cctcagcccc aggagaaggg acaaaaggta    780

ctggtgaggg caagaggtgc ctgggaggag tggccctgat ccaggaaaat gtgaggggaa    840

tctggaacgc tctaggcaga agaagctggg agggaggggg aggtgaaaag ggcagaggca    900

aggatggtgg ggcccccagc accctctgtt agtgccgcaa taaatgctca atcatgtgcc    960

aga                                                                  963


<210>  1076
<211>  167
<212>  PRT
<213>  Homosapiens

<400>  1076

Met Ala Thr Ser Glu Leu Ser Cys Glu Val Ser Glu Glu Asn Cys Glu 
1               5                   10                  15      


Arg Arg Glu Ala Phe Trp Ala Glu Trp Lys Asp Leu Thr Leu Ser Thr 
            20                  25                  30          


Arg Pro Glu Glu Gly Cys Ser Leu His Glu Glu Asp Thr Gln Arg His 
        35                  40                  45              


Glu Thr Tyr His Gln Gln Gly Gln Cys Gln Val Leu Val Gln Arg Ser 
    50                  55                  60                  


Pro Trp Leu Met Met Arg Met Gly Ile Leu Gly Arg Gly Leu Gln Glu 
65                  70                  75                  80  


Tyr Gln Leu Pro Tyr Gln Arg Val Leu Pro Leu Pro Ile Phe Thr Pro 
                85                  90                  95      


Ala Lys Met Gly Ala Thr Lys Glu Glu Arg Glu Asp Thr Pro Ile Gln 
            100                 105                 110         


Leu Gln Glu Leu Leu Ala Leu Glu Thr Ala Leu Gly Gly Gln Cys Val 
        115                 120                 125             


Asp Arg Gln Glu Val Ala Glu Ile Thr Lys Gln Leu Pro Pro Val Val 
    130                 135                 140                 


Pro Val Ser Lys Pro Gly Ala Leu Arg Arg Ser Leu Ser Arg Ser Met 
145                 150                 155                 160 


Ser Gln Glu Ala Gln Arg Gly 
                165         


<210>  1077
<211>  1212
<212>  DNA
<213>  Homosapiens

<400>  1077
ggacgattgc cgctgcagcc gccgccccac tcacctccgg tgtgtctgca gcccggacac     60

taagggagat ggatgaatgg gtggggagga tgcggcgcac atggccccgg gcggctcggc    120

ggtcagctgc cgcccccaca gcggaccggt cggggcgggg gtcgggcggt agaaaaaagg    180

gccgcgaggc gagcggggca ctgggcggac cgcggcggca gcatgagcgg cgcagaccgt    240

agccccaatg cgggcgcagc ccctgactcg gccccgggcc aggcggcggt ggcttcggcc    300

taccagcgct tcgagccgcg cgcctacctc cgcaacaact acgcgccccc tcgcggggac    360

ctgtgcaacc cgaacggcgt cgggccgtgg aagctgcgct gcttggcgca gaccttcgcc    420

accggtgaag tgtccggacg caccctcatc gacattggtt caggccccac cgtgtaccag    480

ctgctcagtg cctgcagcca ctttgaggac atcaccatga cagatttcct ggaggtcaac    540

cgccaggagc tggggcgctg gctgcaggag gagccggggg ccttcaactg gagcatgtac    600

agccaacatg cctgcctcat tgagggcaag ggggaatgct ggcaggataa ggagcgccag    660

ctgcgagcca gggtgaaacg ggtcctgccc atcgacgtgc accagcccca gcccctgggt    720

gctgggagcc cagctcccct gcctgctgac gccctggtct ctgccttctg cttggaggct    780

gtgagcccag atcttgccag ctttcagcgg gccctggacc acatcaccac gctgctgagg    840

cctggggggc acctcctcct catcggggcc ctggaggagt cgtggtacct ggctggggag    900

gccaggctga cggtggtgcc agtgtctgag gaggaggtga gggaggccct ggtgcgtagt    960

ggctacaagg tccgggacct ccgcacctat atcatgcctg cccaccttca gacaggcgta   1020

gatgatgtca agggcgtctt cttcgcctgg gctcagaagg ttgggctgtg agggctgtac   1080

ctggtgccct gtggccccca cccacctgga ttccctgttc tttgaagtgg cacctaataa   1140

agaaataata ccctgccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1200

aaaaaaaaaa aa                                                       1212


<210>  1078
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  1078

Met Ser Gly Ala Asp Arg Ser Pro Asn Ala Gly Ala Ala Pro Asp Ser 
1               5                   10                  15      


Ala Pro Gly Gln Ala Ala Val Ala Ser Ala Tyr Gln Arg Phe Glu Pro 
            20                  25                  30          


Arg Ala Tyr Leu Arg Asn Asn Tyr Ala Pro Pro Arg Gly Asp Leu Cys 
        35                  40                  45              


Asn Pro Asn Gly Val Gly Pro Trp Lys Leu Arg Cys Leu Ala Gln Thr 
    50                  55                  60                  


Phe Ala Thr Gly Glu Val Ser Gly Arg Thr Leu Ile Asp Ile Gly Ser 
65                  70                  75                  80  


Gly Pro Thr Val Tyr Gln Leu Leu Ser Ala Cys Ser His Phe Glu Asp 
                85                  90                  95      


Ile Thr Met Thr Asp Phe Leu Glu Val Asn Arg Gln Glu Leu Gly Arg 
            100                 105                 110         


Trp Leu Gln Glu Glu Pro Gly Ala Phe Asn Trp Ser Met Tyr Ser Gln 
        115                 120                 125             


His Ala Cys Leu Ile Glu Gly Lys Gly Glu Cys Trp Gln Asp Lys Glu 
    130                 135                 140                 


Arg Gln Leu Arg Ala Arg Val Lys Arg Val Leu Pro Ile Asp Val His 
145                 150                 155                 160 


Gln Pro Gln Pro Leu Gly Ala Gly Ser Pro Ala Pro Leu Pro Ala Asp 
                165                 170                 175     


Ala Leu Val Ser Ala Phe Cys Leu Glu Ala Val Ser Pro Asp Leu Ala 
            180                 185                 190         


Ser Phe Gln Arg Ala Leu Asp His Ile Thr Thr Leu Leu Arg Pro Gly 
        195                 200                 205             


Gly His Leu Leu Leu Ile Gly Ala Leu Glu Glu Ser Trp Tyr Leu Ala 
    210                 215                 220                 


Gly Glu Ala Arg Leu Thr Val Val Pro Val Ser Glu Glu Glu Val Arg 
225                 230                 235                 240 


Glu Ala Leu Val Arg Ser Gly Tyr Lys Val Arg Asp Leu Arg Thr Tyr 
                245                 250                 255     


Ile Met Pro Ala His Leu Gln Thr Gly Val Asp Asp Val Lys Gly Val 
            260                 265                 270         


Phe Phe Ala Trp Ala Gln Lys Val Gly Leu 
        275                 280         


<210>  1079
<211>  2708
<212>  DNA
<213>  Homosapiens

<400>  1079
atactcctaa gctcctcccc cggcggcgag ccagggagaa aggatggccg gcctggcggc     60

gcggttggtc ctgctagctg gggcagcggc gctggcgagc ggctcccagg gcgaccgtga    120

gccggtgtac cgcgactgcg tactgcagtg cgaagagcag aactgctctg ggggcgctct    180

gaatcacttc cgctcccgcc agccaatcta catgagtcta gcaggctgga cctgtcggga    240

cgactgtaag tatgagtgta tgtgggtcac cgttgggctc tacctccagg aaggtcacaa    300

agtgcctcag ttccatggca agtggccctt ctcccggttc ctgttctttc aagagccggc    360

atcggccgtg gcctcgtttc tcaatggcct ggccagcctg gtgatgctct gccgctaccg    420

caccttcgtg ccagcctcct cccccatgta ccacacctgt gtggccttcg cctgggtgtc    480

cctcaatgca tggttctggt ccacagtttt ccacaccagg gacactgacc tcacagagaa    540

aatggactac ttctgtgcct ccactgtcat cctacactca atctacctgt gctgcgtcag    600

gaccgtgggg ctgcagcacc cagctgtggt cagtgccttc cgggctctcc tgctgctcat    660

gctgaccgtg cacgtctcct acctgagcct catccgcttc gactatggct acaacctggt    720

ggccaacgtg gctattggcc tggtcaacgt ggtgtggtgg ctggcctggt gcctgtggaa    780

ccagcggcgg ctgcctcacg tgcgcaagtg cgtggtggtg gtcttgctgc tgcaggggct    840

gtccctgctc gagctgcttg acttcccacc gctcttctgg gtcctggatg cccatgccat    900

ctggcacatc agcaccatcc ctgtccacgt cctctttttc agctttctgg aagatgacag    960

cctgtacctg ctgaaggaat cagaggacaa gttcaagctg gactgaagac cttggagcga   1020

gtctgcccca gtggggatcc tgcccccgcc ctgctggcct cccttctccc ctcaaccctt   1080

gagatgattt tctcttttca acttcttgaa cttggacatg aaggatgtgg gcccagaatc   1140

atgtggccag cccaccccct gttggccctc accagccttg gagtctgttc tagggaaggc   1200

ctcccagcat ctgggactcg agagtgggca gcccctctac ctcctggagc tgaactgggg   1260

tggaactgag tgtgctctta gctctaccgg gaggacagct gcctgtttcc tccccatcag   1320

cctcctcccc acatccccag ctgcctggct gggtcctgaa gccctctgtc tacctgggag   1380

accagggacc acaggcctta gggatacagg gggtcccctt ctgttaccac cccccaccct   1440

cctccaggac accactaggt ggtgctggat gcttgttctt tggccagcca aggttcacgg   1500

cgattctccc catgggatct tgagggacca agctgctggg attgggaagg agtttcaccc   1560

tgaccattgc cctagccagg ttcccaggag gcctcaccat actccctttc agggccaggg   1620

ctccagcaag cccagggcaa ggatcctgtg ctgctgtctg gttgagagcc tgccaccgtg   1680

tgtcgggagt gtgggccagg ctgagtgcat aggtgacagg gccgtgagca tgggcctggg   1740

tgtgtgtgag ctcaggccta ggtgcgcagt gtggagacgg gtgttgtcgg ggaagaggtg   1800

tggcttcaaa gtgtgtgtgt gcagggggtg ggtgtgttag cgtgggttag gggaacgtgt   1860

gtgcgcgtgc tggtgggcat gtgagatgag tgactgccgg tgaatgtgtc cacagttgag   1920

aggttggagc aggatgaggg aatcctgtca ccatcaataa tcacttgtgg agcgccagct   1980

ctgcccaagg cgccacctgg gcggacagcc aggagctctc catggccagg ctgcctgtgt   2040

gcatgttccc tgtctggtgc ccctttgccc gcctcctgca aacctcacag ggtccccaca   2100

caacagtgcc ctccagaagc agcccctcgg aggcagagga aggaaaatgg ggatggctgg   2160

ggctctctcc atcctccttt tctccttgcc ttcgcatggc tggccttccc ctccaaaacc   2220

tccattcccc tgctgccagc ccctttgcca tagcctgatt ttggggagga ggaaggggcg   2280

atttgaggga gaaggggaga aagcttatgg ctgggtctgg tttcttccct tcccagaggg   2340

tcttactgtt ccagggtggc cccagggcag gcaggggcca cactatgcct gcgccctggt   2400

aaaggtgacc cctgccattt accagcagcc ctggcatgtt cctgccccac aggaatagaa   2460

tggagggagc tccagaaact ttccatccca aaggcagtct ccgtggttga agcagactgg   2520

atttttgctc tgcccctgac cccttgtccc tctttgaggg aggggagcta tgctaggact   2580

ccaacctcag ggactcgggt ggcctgcgct agcttctttt gatactgaaa acttttaagg   2640

tgggagggtg gcaagggatg tgcttaataa atcaattcca agcctcaaaa aaaaaaaaaa   2700

aaaaaaaa                                                            2708


<210>  1080
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  1080

Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 
1               5                   10                  15      


Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 
            20                  25                  30          


Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 
        35                  40                  45              


Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 
    50                  55                  60                  


Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 
65                  70                  75                  80  


Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Trp Pro Phe 
                85                  90                  95      


Ser Arg Phe Leu Phe Phe Gln Glu Pro Ala Ser Ala Val Ala Ser Phe 
            100                 105                 110         


Leu Asn Gly Leu Ala Ser Leu Val Met Leu Cys Arg Tyr Arg Thr Phe 
        115                 120                 125             


Val Pro Ala Ser Ser Pro Met Tyr His Thr Cys Val Ala Phe Ala Trp 
    130                 135                 140                 


Val Ser Leu Asn Ala Trp Phe Trp Ser Thr Val Phe His Thr Arg Asp 
145                 150                 155                 160 


Thr Asp Leu Thr Glu Lys Met Asp Tyr Phe Cys Ala Ser Thr Val Ile 
                165                 170                 175     


Leu His Ser Ile Tyr Leu Cys Cys Val Arg Thr Val Gly Leu Gln His 
            180                 185                 190         


Pro Ala Val Val Ser Ala Phe Arg Ala Leu Leu Leu Leu Met Leu Thr 
        195                 200                 205             


Val His Val Ser Tyr Leu Ser Leu Ile Arg Phe Asp Tyr Gly Tyr Asn 
    210                 215                 220                 


Leu Val Ala Asn Val Ala Ile Gly Leu Val Asn Val Val Trp Trp Leu 
225                 230                 235                 240 


Ala Trp Cys Leu Trp Asn Gln Arg Arg Leu Pro His Val Arg Lys Cys 
                245                 250                 255     


Val Val Val Val Leu Leu Leu Gln Gly Leu Ser Leu Leu Glu Leu Leu 
            260                 265                 270         


Asp Phe Pro Pro Leu Phe Trp Val Leu Asp Ala His Ala Ile Trp His 
        275                 280                 285             


Ile Ser Thr Ile Pro Val His Val Leu Phe Phe Ser Phe Leu Glu Asp 
    290                 295                 300                 


Asp Ser Leu Tyr Leu Leu Lys Glu Ser Glu Asp Lys Phe Lys Leu Asp 
305                 310                 315                 320 


<210>  1081
<211>  4816
<212>  DNA
<213>  Homosapiens

<400>  1081
gttcccggat ttttgtgggc gcctgccccg cccctcgtcc ccctgctgtg tccatatatc     60

gaggcgatag ggttaaggga aggcggacgc ctgatgggtt aatgagcaaa ctgaagtgtt    120

ttccatgatc ttttttgagt cgcaattgaa gtaccacctc ccgagggtga ttgcttcccc    180

atgcggggta gaacctttgc tgtcctgttc accactctac ctccagcaca gaatttggct    240

tatgcctact caatgtgaag atgatgagga tgaaaacctt tgtgatgatc cacttccact    300

taatgaatgg tggcaaagca aagctatatt caagaccaca tgcaaagcta ctccctgagc    360

aaagagtcac agataaaacg ggggcaccag tagaatggcc aggacaaacg cagtgcagca    420

cagagactca gaccctggca gccatgcctg cgcaggcagt gatgagagtg acatgtactg    480

ttgtggacat gcacaaaagt gagtgtgcac cggcacagac atgaagctgc ggctccctgc    540

cagtcccgag acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca    600

gggaaacctg gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat    660

ccaggaggtg cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca    720

gaggctgcgg attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct    780

agacaatgga gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct    840

gcgggagctg cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg    900

gaacccccag ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa    960

ccagctggct ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc   1020

gatgtgtaag ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg   1080

cactgtctgt gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca   1140

tgagcagtgt gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca   1200

cttcaaccac agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga   1260

cacgtttgag tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac   1320

tgcctgtccc tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct   1380

gcacaaccaa gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc   1440

ctgtgcccga gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac   1500

cagtgccaat atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct   1560

gccggagagc tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct   1620

ccaagtgttt gagactctgg aagagatcac aggttaccta tacatctcag catggccgga   1680

cagcctgcct gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca   1740

caatggcgcc tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc   1800

actgagggaa ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt   1860

gcacacggtg ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc   1920

caaccggcca gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg   1980

agggcactgc tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg   2040

ccaggagtgc gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc   2100

caggcactgt ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt   2160

tggaccggag gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt   2220

ggcccgctgc cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc   2280

agatgaggag ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct   2340

ggatgacaag ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc   2400

ggtggttggc attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg   2460

acggcagcag aagatccgga agtacacgat gcggagactg ctgcaggaaa cggagctggt   2520

ggagccgctg acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga   2580

gacggagctg aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg   2640

catctggatc cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga   2700

aaacacatcc cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggctggtgt   2760

gggctcccca tatgtctccc gccttctggg catctgcctg acatccacgg tgcagctggt   2820

gacacagctt atgccctatg gctgcctctt agaccatgtc cgggaaaacc gcggacgcct   2880

gggctcccag gacctgctga actggtgtat gcagattgcc aaggggatga gctacctgga   2940

ggatgtgcgg ctcgtacaca gggacttggc cgctcggaac gtgctggtca agagtcccaa   3000

ccatgtcaaa attacagact tcgggctggc tcggctgctg gacattgacg agacagagta   3060

ccatgcagat gggggcaagg tgcccatcaa gtggatggcg ctggagtcca ttctccgccg   3120

gcggttcacc caccagagtg atgtgtggag ttatggtgtg actgtgtggg agctgatgac   3180

ttttggggcc aaaccttacg atgggatccc agcccgggag atccctgacc tgctggaaaa   3240

gggggagcgg ctgccccagc cccccatctg caccattgat gtctacatga tcatggtcaa   3300

atgttggatg attgactctg aatgtcggcc aagattccgg gagttggtgt ctgaattctc   3360

ccgcatggcc agggaccccc agcgctttgt ggtcatccag aatgaggact tgggcccagc   3420

cagtcccttg gacagcacct tctaccgctc actgctggag gacgatgaca tgggggacct   3480

ggtggatgct gaggagtatc tggtacccca gcagggcttc ttctgtccag accctgcccc   3540

gggcgctggg ggcatggtcc accacaggca ccgcagctca tctaccagga gtggcggtgg   3600

ggacctgaca ctagggctgg agccctctga agaggaggcc cccaggtctc cactggcacc   3660

ctccgaaggg gctggctccg atgtatttga tggtgacctg ggaatggggg cagccaaggg   3720

gctgcaaagc ctccccacac atgaccccag ccctctacag cggtacagtg aggaccccac   3780

agtacccctg ccctctgaga ctgatggcta cgttgccccc ctgacctgca gcccccagcc   3840

tgaatatgtg aaccagccag atgttcggcc ccagccccct tcgccccgag agggccctct   3900

gcctgctgcc cgacctgctg gtgccactct ggaaaggccc aagactctct ccccagggaa   3960

gaatggggtc gtcaaagacg tttttgcctt tgggggtgcc gtggagaacc ccgagtactt   4020

gacaccccag ggaggagctg cccctcagcc ccaccctcct cctgccttca gcccagcctt   4080

cgacaacctc tattactggg accaggaccc accagagcgg ggggctccac ccagcacctt   4140

caaagggaca cctacggcag agaacccaga gtacctgggt ctggacgtgc cagtgtgaac   4200

cagaaggcca agtccgcaga agccctgatg tgtcctcagg gagcagggaa ggcctgactt   4260

ctgctggcat caagaggtgg gagggccctc cgaccacttc caggggaacc tgccatgcca   4320

ggaacctgtc ctaaggaacc ttccttcctg cttgagttcc cagatggctg gaaggggtcc   4380

agcctcgttg gaagaggaac agcactgggg agtctttgtg gattctgagg ccctgcccaa   4440

tgagactcta gggtccagtg gatgccacag cccagcttgg ccctttcctt ccagatcctg   4500

ggtactgaaa gccttaggga agctggcctg agaggggaag cggccctaag ggagtgtcta   4560

agaacaaaag cgacccattc agagactgtc cctgaaacct agtactgccc cccatgagga   4620

aggaacagca atggtgtcag tatccaggct ttgtacagag tgcttttctg tttagttttt   4680

actttttttg ttttgttttt ttaaagatga aataaagacc cagggggaga atgggtgttg   4740

tatggggagg caagtgtggg gggtccttct ccacacccac tttgtccatt tgcaaatata   4800

ttttggaaaa cagcta                                                   4816


<210>  1082
<211>  1225
<212>  PRT
<213>  Homosapiens

<400>  1082

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  1083
<211>  4624
<212>  DNA
<213>  Homosapiens

<400>  1083
ggaggaggtg gaggaggagg gctgcttgag gaagtataag aatgaagttg tgaagctgag     60

attcccctcc attgggaccg gagaaaccag gggagccccc cgggcagccg cgcgcccctt    120

cccacggggc cctttactgc gccgcgcgcc cggcccccac ccctcgcagc accccgcgcc    180

ccgcgccctc ccagccgggt ccagccggag ccatggggcc ggagccgcag tgagcaccat    240

ggagctggcg gccttgtgcc gctgggggct cctcctcgcc ctcttgcccc ccggagccgc    300

gagcacccaa gtgtgcaccg gcacagacat gaagctgcgg ctccctgcca gtcccgagac    360

ccacctggac atgctccgcc acctctacca gggctgccag gtggtgcagg gaaacctgga    420

actcacctac ctgcccacca atgccagcct gtccttcctg caggatatcc aggaggtgca    480

gggctacgtg ctcatcgctc acaaccaagt gaggcaggtc ccactgcaga ggctgcggat    540

tgtgcgaggc acccagctct ttgaggacaa ctatgccctg gccgtgctag acaatggaga    600

cccgctgaac aataccaccc ctgtcacagg ggcctcccca ggaggcctgc gggagctgca    660

gcttcgaagc ctcacagaga tcttgaaagg aggggtcttg atccagcgga acccccagct    720

ctgctaccag gacacgattt tgtggaagga catcttccac aagaacaacc agctggctct    780

cacactgata gacaccaacc gctctcgggc ctgccacccc tgttctccga tgtgtaaggg    840

ctcccgctgc tggggagaga gttctgagga ttgtcagagc ctgacgcgca ctgtctgtgc    900

cggtggctgt gcccgctgca aggggccact gcccactgac tgctgccatg agcagtgtgc    960

tgccggctgc acgggcccca agcactctga ctgcctggcc tgcctccact tcaaccacag   1020

tggcatctgt gagctgcact gcccagccct ggtcacctac aacacagaca cgtttgagtc   1080

catgcccaat cccgagggcc ggtatacatt cggcgccagc tgtgtgactg cctgtcccta   1140

caactacctt tctacggacg tgggatcctg caccctcgtc tgccccctgc acaaccaaga   1200

ggtgacagca gaggatggaa cacagcggtg tgagaagtgc agcaagccct gtgcccgagt   1260

gtgctatggt ctgggcatgg agcacttgcg agaggtgagg gcagttacca gtgccaatat   1320

ccaggagttt gctggctgca agaagatctt tgggagcctg gcatttctgc cggagagctt   1380

tgatggggac ccagcctcca acactgcccc gctccagcca gagcagctcc aagtgtttga   1440

gactctggaa gagatcacag gttacctata catctcagca tggccggaca gcctgcctga   1500

cctcagcgtc ttccagaacc tgcaagtaat ccggggacga attctgcaca atggcgccta   1560

ctcgctgacc ctgcaagggc tgggcatcag ctggctgggg ctgcgctcac tgagggaact   1620

gggcagtgga ctggccctca tccaccataa cacccacctc tgcttcgtgc acacggtgcc   1680

ctgggaccag ctctttcgga acccgcacca agctctgctc cacactgcca accggccaga   1740

ggacgagtgt gtgggcgagg gcctggcctg ccaccagctg tgcgcccgag ggcactgctg   1800

gggtccaggg cccacccagt gtgtcaactg cagccagttc cttcggggcc aggagtgcgt   1860

ggaggaatgc cgagtactgc aggggctccc cagggagtat gtgaatgcca ggcactgttt   1920

gccgtgccac cctgagtgtc agccccagaa tggctcagtg acctgttttg gaccggaggc   1980

tgaccagtgt gtggcctgtg cccactataa ggaccctccc ttctgcgtgg cccgctgccc   2040

cagcggtgtg aaacctgacc tctcctacat gcccatctgg aagtttccag atgaggaggg   2100

cgcatgccag ccttgcccca tcaactgcac ccactcctgt gtggacctgg atgacaaggg   2160

ctgccccgcc gagcagagag ccagccctct gacgtccatc atctctgcgg tggttggcat   2220

tctgctggtc gtggtcttgg gggtggtctt tgggatcctc atcaagcgac ggcagcagaa   2280

gatccggaag tacacgatgc ggagactgct gcaggaaacg gagctggtgg agccgctgac   2340

acctagcgga gcgatgccca accaggcgca gatgcggatc ctgaaagaga cggagctgag   2400

gaaggtgaag gtgcttggat ctggcgcttt tggcacagtc tacaagggca tctggatccc   2460

tgatggggag aatgtgaaaa ttccagtggc catcaaagtg ttgagggaaa acacatcccc   2520

caaagccaac aaagaaatct tagacgaagc atacgtgatg gctggtgtgg gctccccata   2580

tgtctcccgc cttctgggca tctgcctgac atccacggtg cagctggtga cacagcttat   2640

gccctatggc tgcctcttag accatgtccg ggaaaaccgc ggacgcctgg gctcccagga   2700

cctgctgaac tggtgtatgc agattgccaa ggggatgagc tacctggagg atgtgcggct   2760

cgtacacagg gacttggccg ctcggaacgt gctggtcaag agtcccaacc atgtcaaaat   2820

tacagacttc gggctggctc ggctgctgga cattgacgag acagagtacc atgcagatgg   2880

gggcaaggtg cccatcaagt ggatggcgct ggagtccatt ctccgccggc ggttcaccca   2940

ccagagtgat gtgtggagtt atggtgtgac tgtgtgggag ctgatgactt ttggggccaa   3000

accttacgat gggatcccag cccgggagat ccctgacctg ctggaaaagg gggagcggct   3060

gccccagccc cccatctgca ccattgatgt ctacatgatc atggtcaaat gttggatgat   3120

tgactctgaa tgtcggccaa gattccggga gttggtgtct gaattctccc gcatggccag   3180

ggacccccag cgctttgtgg tcatccagaa tgaggacttg ggcccagcca gtcccttgga   3240

cagcaccttc taccgctcac tgctggagga cgatgacatg ggggacctgg tggatgctga   3300

ggagtatctg gtaccccagc agggcttctt ctgtccagac cctgccccgg gcgctggggg   3360

catggtccac cacaggcacc gcagctcatc taccaggagt ggcggtgggg acctgacact   3420

agggctggag ccctctgaag aggaggcccc caggtctcca ctggcaccct ccgaaggggc   3480

tggctccgat gtatttgatg gtgacctggg aatgggggca gccaaggggc tgcaaagcct   3540

ccccacacat gaccccagcc ctctacagcg gtacagtgag gaccccacag tacccctgcc   3600

ctctgagact gatggctacg ttgcccccct gacctgcagc ccccagcctg aatatgtgaa   3660

ccagccagat gttcggcccc agcccccttc gccccgagag ggccctctgc ctgctgcccg   3720

acctgctggt gccactctgg aaaggcccaa gactctctcc ccagggaaga atggggtcgt   3780

caaagacgtt tttgcctttg ggggtgccgt ggagaacccc gagtacttga caccccaggg   3840

aggagctgcc cctcagcccc accctcctcc tgccttcagc ccagccttcg acaacctcta   3900

ttactgggac caggacccac cagagcgggg ggctccaccc agcaccttca aagggacacc   3960

tacggcagag aacccagagt acctgggtct ggacgtgcca gtgtgaacca gaaggccaag   4020

tccgcagaag ccctgatgtg tcctcaggga gcagggaagg cctgacttct gctggcatca   4080

agaggtggga gggccctccg accacttcca ggggaacctg ccatgccagg aacctgtcct   4140

aaggaacctt ccttcctgct tgagttccca gatggctgga aggggtccag cctcgttgga   4200

agaggaacag cactggggag tctttgtgga ttctgaggcc ctgcccaatg agactctagg   4260

gtccagtgga tgccacagcc cagcttggcc ctttccttcc agatcctggg tactgaaagc   4320

cttagggaag ctggcctgag aggggaagcg gccctaaggg agtgtctaag aacaaaagcg   4380

acccattcag agactgtccc tgaaacctag tactgccccc catgaggaag gaacagcaat   4440

ggtgtcagta tccaggcttt gtacagagtg cttttctgtt tagtttttac tttttttgtt   4500

ttgttttttt aaagatgaaa taaagaccca gggggagaat gggtgttgta tggggaggca   4560

agtgtggggg gtccttctcc acacccactt tgtccatttg caaatatatt ttggaaaaca   4620

gcta                                                                4624


<210>  1084
<211>  1255
<212>  PRT
<213>  Homosapiens

<400>  1084

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  1085
<211>  781
<212>  DNA
<213>  Homosapiens

<400>  1085
gtcacacccg gaagcagggg cccgagcgga gccggccgcg atgagcgggg agccggggca     60

gacgtccgta gcgccccctc ccgaggaggt cgagccgggc agtggggtcc gcatcgtggt    120

ggagtactgt gaaccctgcg gcttcgaggc gacctacctg gagctggcca gtgctgtgaa    180

ggagcagtat ccgggcatcg agatcgagtc gcgcctcggg ggcacaggtg cctttgagat    240

agagataaat ggacagctgg tgttctccaa gctggagaat gggggctttc cctatgagaa    300

agatctcatt gaggccatcc gaagagccag taatggagaa accctagaaa agatcaccaa    360

cagccgtcct ccctgcgtca tcctgtgact gcacaggact ctgggttcct gctctgttct    420

ggggtccaaa ccttggtctc cctttggtcc tgctgggagc tccccctgcc tctttcccct    480

acttagctcc ttagcaaaga gaccctggcc tccactttgc cctttgggta caaagaagga    540

atagaagatt ccgtggcctt gggggcagga gagagacact ctccatgaac acttctccag    600

ccacctcata cccccttccc agggtaagtg cccacgaaag cccagtccac tcttcgcctc    660

ggtaatacct gtctgatgcc acagatttta tttattctcc cctaacccag ggcaatgtca    720

gctattggca gtaaagtggc gctacaaaca ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa    780

a                                                                    781


<210>  1086
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  1086

Met Ser Gly Glu Pro Gly Gln Thr Ser Val Ala Pro Pro Pro Glu Glu 
1               5                   10                  15      


Val Glu Pro Gly Ser Gly Val Arg Ile Val Val Glu Tyr Cys Glu Pro 
            20                  25                  30          


Cys Gly Phe Glu Ala Thr Tyr Leu Glu Leu Ala Ser Ala Val Lys Glu 
        35                  40                  45              


Gln Tyr Pro Gly Ile Glu Ile Glu Ser Arg Leu Gly Gly Thr Gly Ala 
    50                  55                  60                  


Phe Glu Ile Glu Ile Asn Gly Gln Leu Val Phe Ser Lys Leu Glu Asn 
65                  70                  75                  80  


Gly Gly Phe Pro Tyr Glu Lys Asp Leu Ile Glu Ala Ile Arg Arg Ala 
                85                  90                  95      


Ser Asn Gly Glu Thr Leu Glu Lys Ile Thr Asn Ser Arg Pro Pro Cys 
            100                 105                 110         


Val Ile Leu 
        115 


<210>  1087
<211>  2116
<212>  DNA
<213>  Homosapiens

<400>  1087
cgtctccctc cctgaagacg tggtcccagc cgggtgtcct gacgctcggg gttcaggaca     60

agggcacaca actggttccg ttaagcccct ctcttgctca gacgccatgg agctggatct    120

gtctccacct catcttagca gctctccgga agacctttgc ccagcccctg ggacccctcc    180

tgggactccc cggccccctg atacccctct gcctgaggag gtaaagaggt cccagcctct    240

cctcatccca accaccggca ggaaacttcg agaggaggag aggcgtgcca cctccctccc    300

ctctatcccc aaccccttcc ctgagctctg cagtcctccc tcacagagcc caattctcgg    360

gggcccctcc agtgcaaggg ggctgctccc ccgcgatgcc agccgccccc atgtagtaaa    420

ggtgtacagt gaggatgggg cctgcaggtc tgtggaggtg gcagcaggtg ccacagctcg    480

ccacgtgtgt gaaatgctgg tgcagcgagc tcacgccttg agcgacgaga cctgggggct    540

ggtggagtgc cacccccacc tagcactgga gcggggtttg gaggaccacg agtccgtggt    600

ggaagtgcag gctgcctggc ccgtgggcgg agatagccgc ttcgtcttcc ggaaaaactt    660

cgccaagtac gaactgttca agagctcccc acactccctg ttcccagaaa aaatggtctc    720

cagctgtctc gatgcacaca ctggtatatc ccatgaagac ctcatccaga acttcctgaa    780

tgctggcagc tttcctgaga tccagggctt tctgcagctg cggggttcag gacggaagct    840

ttggaaacgc tttttctgct tcttgcgccg atctggcctc tattactcca ccaagggcac    900

ctctaaggat ccgaggcacc tgcagtacgt ggcagatgtg aacgagtcca acgtgtacgt    960

ggtgacgcag ggccgcaagc tctacgggat gcccactgac ttcggtttct gtgtcaagcc   1020

caacaagctt cgaaatggcc acaaggggct tcggatcttc tgcagtgaag atgagcagag   1080

ccgcacctgc tggctggctg ccttccgcct cttcaagtac ggggtgcagc tgtacaagaa   1140

ttaccagcag gcacagtctc gccatctgca tccatcttgt ttgggctccc cacccttgag   1200

aagtgcctca gataataccc tggtggccat ggacttctct ggccatgctg ggcgtgtcat   1260

tgagaacccc cgggaggctc tgagtgtggc cctggaggag gcccaggcct ggaggaagaa   1320

gacaaaccac cgcctcagcc tgcccatgcc agcctccggc acgagcctca gtgcagccat   1380

ccaccgcacc caactctggt tccacgggcg catttcccgt gaggagagcc agcggcttat   1440

tggacagcag ggcttggtag acggcctgtt cctggtccgg gagagtcagc ggaaccccca   1500

gggctttgtc ctctctttgt gccacctgca gaaagtgaag cattatctca tcctgccgag   1560

cgaggaggag ggccgcctgt acttcagcat ggatgatggc cagacccgct tcactgacct   1620

gctgcagctc gtggagttcc accagctgaa ccgcggcatc ctgccgtgct tgctgcgcca   1680

ttgctgcacg cgggtggccc tctgaccagg ccgtggactg gctcatgcct cagcccgcct   1740

tcaggctgcc cgccgcccct ccacccatcc agtggactct ggggcgcggc cacaggggac   1800

gggatgagga gcgggagggt tccgccactc cagttttctc ctctgcttct ttgcctccct   1860

cagatagaaa acagccccca ctccagtcca ctcctgaccc ctctcctcaa gggaaggcct   1920

tgggtggccc cctctccttc tcctagctct ggaggtgctg ctctagggca gggaattatg   1980

ggagaagtgg gggcagccca ggcggtttca cgccccacac tttgtacaga ccgagaggcc   2040

agttgatctg ctctgtttta tactagtgac aataaagatt attttttgat acaaaaaaaa   2100

aaaaaaaaaa aaaaaa                                                   2116


<210>  1088
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  1088

Met Glu Leu Asp Leu Ser Pro Pro His Leu Ser Ser Ser Pro Glu Asp 
1               5                   10                  15      


Leu Cys Pro Ala Pro Gly Thr Pro Pro Gly Thr Pro Arg Pro Pro Asp 
            20                  25                  30          


Thr Pro Leu Pro Glu Glu Val Lys Arg Ser Gln Pro Leu Leu Ile Pro 
        35                  40                  45              


Thr Thr Gly Arg Lys Leu Arg Glu Glu Glu Arg Arg Ala Thr Ser Leu 
    50                  55                  60                  


Pro Ser Ile Pro Asn Pro Phe Pro Glu Leu Cys Ser Pro Pro Ser Gln 
65                  70                  75                  80  


Ser Pro Ile Leu Gly Gly Pro Ser Ser Ala Arg Gly Leu Leu Pro Arg 
                85                  90                  95      


Asp Ala Ser Arg Pro His Val Val Lys Val Tyr Ser Glu Asp Gly Ala 
            100                 105                 110         


Cys Arg Ser Val Glu Val Ala Ala Gly Ala Thr Ala Arg His Val Cys 
        115                 120                 125             


Glu Met Leu Val Gln Arg Ala His Ala Leu Ser Asp Glu Thr Trp Gly 
    130                 135                 140                 


Leu Val Glu Cys His Pro His Leu Ala Leu Glu Arg Gly Leu Glu Asp 
145                 150                 155                 160 


His Glu Ser Val Val Glu Val Gln Ala Ala Trp Pro Val Gly Gly Asp 
                165                 170                 175     


Ser Arg Phe Val Phe Arg Lys Asn Phe Ala Lys Tyr Glu Leu Phe Lys 
            180                 185                 190         


Ser Ser Pro His Ser Leu Phe Pro Glu Lys Met Val Ser Ser Cys Leu 
        195                 200                 205             


Asp Ala His Thr Gly Ile Ser His Glu Asp Leu Ile Gln Asn Phe Leu 
    210                 215                 220                 


Asn Ala Gly Ser Phe Pro Glu Ile Gln Gly Phe Leu Gln Leu Arg Gly 
225                 230                 235                 240 


Ser Gly Arg Lys Leu Trp Lys Arg Phe Phe Cys Phe Leu Arg Arg Ser 
                245                 250                 255     


Gly Leu Tyr Tyr Ser Thr Lys Gly Thr Ser Lys Asp Pro Arg His Leu 
            260                 265                 270         


Gln Tyr Val Ala Asp Val Asn Glu Ser Asn Val Tyr Val Val Thr Gln 
        275                 280                 285             


Gly Arg Lys Leu Tyr Gly Met Pro Thr Asp Phe Gly Phe Cys Val Lys 
    290                 295                 300                 


Pro Asn Lys Leu Arg Asn Gly His Lys Gly Leu Arg Ile Phe Cys Ser 
305                 310                 315                 320 


Glu Asp Glu Gln Ser Arg Thr Cys Trp Leu Ala Ala Phe Arg Leu Phe 
                325                 330                 335     


Lys Tyr Gly Val Gln Leu Tyr Lys Asn Tyr Gln Gln Ala Gln Ser Arg 
            340                 345                 350         


His Leu His Pro Ser Cys Leu Gly Ser Pro Pro Leu Arg Ser Ala Ser 
        355                 360                 365             


Asp Asn Thr Leu Val Ala Met Asp Phe Ser Gly His Ala Gly Arg Val 
    370                 375                 380                 


Ile Glu Asn Pro Arg Glu Ala Leu Ser Val Ala Leu Glu Glu Ala Gln 
385                 390                 395                 400 


Ala Trp Arg Lys Lys Thr Asn His Arg Leu Ser Leu Pro Met Pro Ala 
                405                 410                 415     


Ser Gly Thr Ser Leu Ser Ala Ala Ile His Arg Thr Gln Leu Trp Phe 
            420                 425                 430         


His Gly Arg Ile Ser Arg Glu Glu Ser Gln Arg Leu Ile Gly Gln Gln 
        435                 440                 445             


Gly Leu Val Asp Gly Leu Phe Leu Val Arg Glu Ser Gln Arg Asn Pro 
    450                 455                 460                 


Gln Gly Phe Val Leu Ser Leu Cys His Leu Gln Lys Val Lys His Tyr 
465                 470                 475                 480 


Leu Ile Leu Pro Ser Glu Glu Glu Gly Arg Leu Tyr Phe Ser Met Asp 
                485                 490                 495     


Asp Gly Gln Thr Arg Phe Thr Asp Leu Leu Gln Leu Val Glu Phe His 
            500                 505                 510         


Gln Leu Asn Arg Gly Ile Leu Pro Cys Leu Leu Arg His Cys Cys Thr 
        515                 520                 525             


Arg Val Ala Leu 
    530         


<210>  1089
<211>  2260
<212>  DNA
<213>  Homosapiens

<400>  1089
ttttagtttc cttgggcctg gaatctggac acacagggct cccccccgcc tctgacttct     60

ctgtccgaag tcgggacacc ctcctaccac ctgtagagaa gcgggagtgg atctgaaata    120

aaatccagga atctgggggt tcctagacgg agccagactt cggaacgggt gtcctgctac    180

tcctgctggg gctcctccag gacaagggca cacaactggt tccgttaagc ccctctcttg    240

ctcagacgcc atggagctgg atctgtctcc acctcatctt agcagctctc cggaagacct    300

ttgcccagcc cctgggaccc ctcctgggac tccccggccc cctgataccc ctctgcctga    360

ggaggtaaag aggtcccagc ctctcctcat cccaaccacc ggcaggaaac ttcgagagga    420

ggagaggcgt gccacctccc tcccctctat ccccaacccc ttccctgagc tctgcagtcc    480

tccctcacag agcccaattc tcgggggccc ctccagtgca agggggctgc tcccccgcga    540

tgccagccgc ccccatgtag taaaggtgta cagtgaggat ggggcctgca ggtctgtgga    600

ggtggcagca ggtgccacag ctcgccacgt gtgtgaaatg ctggtgcagc gagctcacgc    660

cttgagcgac gagacctggg ggctggtgga gtgccacccc cacctagcac tggagcgggg    720

tttggaggac cacgagtccg tggtggaagt gcaggctgcc tggcccgtgg gcggagatag    780

ccgcttcgtc ttccggaaaa acttcgccaa gtacgaactg ttcaagagct ccccacactc    840

cctgttccca gaaaaaatgg tctccagctg tctcgatgca cacactggta tatcccatga    900

agacctcatc cagaacttcc tgaatgctgg cagctttcct gagatccagg gctttctgca    960

gctgcggggt tcaggacgga agctttggaa acgctttttc tgcttcttgc gccgatctgg   1020

cctctattac tccaccaagg gcacctctaa ggatccgagg cacctgcagt acgtggcaga   1080

tgtgaacgag tccaacgtgt acgtggtgac gcagggccgc aagctctacg ggatgcccac   1140

tgacttcggt ttctgtgtca agcccaacaa gcttcgaaat ggccacaagg ggcttcggat   1200

cttctgcagt gaagatgagc agagccgcac ctgctggctg gctgccttcc gcctcttcaa   1260

gtacggggtg cagctgtaca agaattacca gcaggcacag tctcgccatc tgcatccatc   1320

ttgtttgggc tccccaccct tgagaagtgc ctcagataat accctggtgg ccatggactt   1380

ctctggccat gctgggcgtg tcattgagaa cccccgggag gctctgagtg tggccctgga   1440

ggaggcccag gcctggagga agaagacaaa ccaccgcctc agcctgccca tgccagcctc   1500

cggcacgagc ctcagtgcag ccatccaccg cacccaactc tggttccacg ggcgcatttc   1560

ccgtgaggag agccagcggc ttattggaca gcagggcttg gtagacggcc tgttcctggt   1620

ccgggagagt cagcggaacc cccagggctt tgtcctctct ttgtgccacc tgcagaaagt   1680

gaagcattat ctcatcctgc cgagcgagga ggagggccgc ctgtacttca gcatggatga   1740

tggccagacc cgcttcactg acctgctgca gctcgtggag ttccaccagc tgaaccgcgg   1800

catcctgccg tgcttgctgc gccattgctg cacgcgggtg gccctctgac caggccgtgg   1860

actggctcat gcctcagccc gccttcaggc tgcccgccgc ccctccaccc atccagtgga   1920

ctctggggcg cggccacagg ggacgggatg aggagcggga gggttccgcc actccagttt   1980

tctcctctgc ttctttgcct ccctcagata gaaaacagcc cccactccag tccactcctg   2040

acccctctcc tcaagggaag gccttgggtg gccccctctc cttctcctag ctctggaggt   2100

gctgctctag ggcagggaat tatgggagaa gtgggggcag cccaggcggt ttcacgcccc   2160

acactttgta cagaccgaga ggccagttga tctgctctgt tttatactag tgacaataaa   2220

gattattttt tgatacaaaa aaaaaaaaaa aaaaaaaaaa                         2260


<210>  1090
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  1090

Met Glu Leu Asp Leu Ser Pro Pro His Leu Ser Ser Ser Pro Glu Asp 
1               5                   10                  15      


Leu Cys Pro Ala Pro Gly Thr Pro Pro Gly Thr Pro Arg Pro Pro Asp 
            20                  25                  30          


Thr Pro Leu Pro Glu Glu Val Lys Arg Ser Gln Pro Leu Leu Ile Pro 
        35                  40                  45              


Thr Thr Gly Arg Lys Leu Arg Glu Glu Glu Arg Arg Ala Thr Ser Leu 
    50                  55                  60                  


Pro Ser Ile Pro Asn Pro Phe Pro Glu Leu Cys Ser Pro Pro Ser Gln 
65                  70                  75                  80  


Ser Pro Ile Leu Gly Gly Pro Ser Ser Ala Arg Gly Leu Leu Pro Arg 
                85                  90                  95      


Asp Ala Ser Arg Pro His Val Val Lys Val Tyr Ser Glu Asp Gly Ala 
            100                 105                 110         


Cys Arg Ser Val Glu Val Ala Ala Gly Ala Thr Ala Arg His Val Cys 
        115                 120                 125             


Glu Met Leu Val Gln Arg Ala His Ala Leu Ser Asp Glu Thr Trp Gly 
    130                 135                 140                 


Leu Val Glu Cys His Pro His Leu Ala Leu Glu Arg Gly Leu Glu Asp 
145                 150                 155                 160 


His Glu Ser Val Val Glu Val Gln Ala Ala Trp Pro Val Gly Gly Asp 
                165                 170                 175     


Ser Arg Phe Val Phe Arg Lys Asn Phe Ala Lys Tyr Glu Leu Phe Lys 
            180                 185                 190         


Ser Ser Pro His Ser Leu Phe Pro Glu Lys Met Val Ser Ser Cys Leu 
        195                 200                 205             


Asp Ala His Thr Gly Ile Ser His Glu Asp Leu Ile Gln Asn Phe Leu 
    210                 215                 220                 


Asn Ala Gly Ser Phe Pro Glu Ile Gln Gly Phe Leu Gln Leu Arg Gly 
225                 230                 235                 240 


Ser Gly Arg Lys Leu Trp Lys Arg Phe Phe Cys Phe Leu Arg Arg Ser 
                245                 250                 255     


Gly Leu Tyr Tyr Ser Thr Lys Gly Thr Ser Lys Asp Pro Arg His Leu 
            260                 265                 270         


Gln Tyr Val Ala Asp Val Asn Glu Ser Asn Val Tyr Val Val Thr Gln 
        275                 280                 285             


Gly Arg Lys Leu Tyr Gly Met Pro Thr Asp Phe Gly Phe Cys Val Lys 
    290                 295                 300                 


Pro Asn Lys Leu Arg Asn Gly His Lys Gly Leu Arg Ile Phe Cys Ser 
305                 310                 315                 320 


Glu Asp Glu Gln Ser Arg Thr Cys Trp Leu Ala Ala Phe Arg Leu Phe 
                325                 330                 335     


Lys Tyr Gly Val Gln Leu Tyr Lys Asn Tyr Gln Gln Ala Gln Ser Arg 
            340                 345                 350         


His Leu His Pro Ser Cys Leu Gly Ser Pro Pro Leu Arg Ser Ala Ser 
        355                 360                 365             


Asp Asn Thr Leu Val Ala Met Asp Phe Ser Gly His Ala Gly Arg Val 
    370                 375                 380                 


Ile Glu Asn Pro Arg Glu Ala Leu Ser Val Ala Leu Glu Glu Ala Gln 
385                 390                 395                 400 


Ala Trp Arg Lys Lys Thr Asn His Arg Leu Ser Leu Pro Met Pro Ala 
                405                 410                 415     


Ser Gly Thr Ser Leu Ser Ala Ala Ile His Arg Thr Gln Leu Trp Phe 
            420                 425                 430         


His Gly Arg Ile Ser Arg Glu Glu Ser Gln Arg Leu Ile Gly Gln Gln 
        435                 440                 445             


Gly Leu Val Asp Gly Leu Phe Leu Val Arg Glu Ser Gln Arg Asn Pro 
    450                 455                 460                 


Gln Gly Phe Val Leu Ser Leu Cys His Leu Gln Lys Val Lys His Tyr 
465                 470                 475                 480 


Leu Ile Leu Pro Ser Glu Glu Glu Gly Arg Leu Tyr Phe Ser Met Asp 
                485                 490                 495     


Asp Gly Gln Thr Arg Phe Thr Asp Leu Leu Gln Leu Val Glu Phe His 
            500                 505                 510         


Gln Leu Asn Arg Gly Ile Leu Pro Cys Leu Leu Arg His Cys Cys Thr 
        515                 520                 525             


Arg Val Ala Leu 
    530         


<210>  1091
<211>  2320
<212>  DNA
<213>  Homosapiens

<400>  1091
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg     60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg    120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg    180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag    240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg    300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta    360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact    420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc    480

atactggtga acgcccattc cagtgtaatc agtgtggggc atcttttact cagaaaggta    540

acctcctccg ccacattaaa ctgcacacag gggaaaaacc ttttaagtgt cacctctgca    600

actatgcatg ccaaagaaga gatgcgctca cggggcatct taggacacat tctgcaagtg    660

cggaggcaag acacatcaaa gcagagatgg gaagtgaaag agctctcgta ctggacagat    720

tagcaagcaa tgtggcaaaa cgaaaaagct caatgcctca gaaattcatt ggtgagaagc    780

gccactgctt tgatgtcaac tataattcaa gttacatgta tgagaaagag agtgagctca    840

tacagacccg catgatggac caagccatca ataacgccat cagctatctt ggcgccgaag    900

ccctgcgccc cttggtccag acaccgcctg ctcccacctc ggagatggtt ccagttatca    960

gcagcatgta tcccatagcc ctcacccggg ctgagatgtc aaacggtgcc cctcaagagc   1020

tggaaaagaa aagcatccac cttccagaga agagcgtgcc ttctgagaga ggcctctctc   1080

ccaacaatag tggccacgac tccacggaca ctgacagcaa ccatgaagaa cgccagaatc   1140

acatctatca gcaaaatcac atggtcctgt ctcgggcccg caatgggatg ccacttctga   1200

aggaggttcc ccgctcttac gaactcctca agcccccgcc catctgccca agagactccg   1260

tcaaagtgat caacaaggaa ggggaggtga tggatgtgta tcggtgtgac cactgccgcg   1320

tcctcttcct ggactatgtg atgttcacga ttcacatggg ctgccacggc ttccgtgacc   1380

ctttcgagtg taacatgtgt ggatatcgaa gccatgatcg gtatgagttc tcgtctcaca   1440

tagccagagg agaacacaga gccctgctga agtgaatatc tggtctcagg gattgctcct   1500

atgtattcag catcgtttct aaaaaccaat gacctcgcct aacagattgc tctcaaaaca   1560

tactcagttc caaacttctt ttcataccat ttttagctgt gttcacaggg gtagccaggg   1620

aaacactgtc ttccttcaga aattattcgc aggtctagca tattattact tttgtgaaac   1680

ctttgttttc ccatcaggga cttgaatttt atggaattta aaagccaaaa aggtatttgg   1740

tcattatctt ctacagcagt ggaatgagtg gtcccggaga tgtgctatat gaaacattct   1800

ttctgagata tatcaaccac acgtggaaaa gcctttcagt catacatgca aatccacaaa   1860

gaggaagagc tgaccagctg accttgctgg gaagcctcac ccttctgccc ttcacaggct   1920

gaagggttaa gatctaatct ccctaatcta aatgacagtc taagagtaag taaaagaaca   1980

gccataaaat aagtatctgt tacgagtaac tgaagacccc attctccaag catcagatcc   2040

atttcctatc acaacatttt taaaaaatgt catctgatgg cacttctgct tctgtccttt   2100

accttcccat ctccagtgaa aagctgagct gctttgggct aaaccagttg tctatagaag   2160

aaaatctatg ccagaagaac tcatggtttt aaatatagac catcatcgaa actccagaaa   2220

tttatccact gtggatgatg acatcgcttt cctttggtca aggttggcag agcaagggta   2280

taaaggggga aattgtttgg cagcaccaac agaaaacaaa                         2320


<210>  1092
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  1092

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Ala Ser Ala Glu Ala Arg His Ile Lys Ala Glu 
        195                 200                 205             


Met Gly Ser Glu Arg Ala Leu Val Leu Asp Arg Leu Ala Ser Asn Val 
    210                 215                 220                 


Ala Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Ile Gly Glu Lys Arg 
225                 230                 235                 240 


His Cys Phe Asp Val Asn Tyr Asn Ser Ser Tyr Met Tyr Glu Lys Glu 
                245                 250                 255     


Ser Glu Leu Ile Gln Thr Arg Met Met Asp Gln Ala Ile Asn Asn Ala 
            260                 265                 270         


Ile Ser Tyr Leu Gly Ala Glu Ala Leu Arg Pro Leu Val Gln Thr Pro 
        275                 280                 285             


Pro Ala Pro Thr Ser Glu Met Val Pro Val Ile Ser Ser Met Tyr Pro 
    290                 295                 300                 


Ile Ala Leu Thr Arg Ala Glu Met Ser Asn Gly Ala Pro Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Lys Ser Ile His Leu Pro Glu Lys Ser Val Pro Ser Glu Arg 
                325                 330                 335     


Gly Leu Ser Pro Asn Asn Ser Gly His Asp Ser Thr Asp Thr Asp Ser 
            340                 345                 350         


Asn His Glu Glu Arg Gln Asn His Ile Tyr Gln Gln Asn His Met Val 
        355                 360                 365             


Leu Ser Arg Ala Arg Asn Gly Met Pro Leu Leu Lys Glu Val Pro Arg 
    370                 375                 380                 


Ser Tyr Glu Leu Leu Lys Pro Pro Pro Ile Cys Pro Arg Asp Ser Val 
385                 390                 395                 400 


Lys Val Ile Asn Lys Glu Gly Glu Val Met Asp Val Tyr Arg Cys Asp 
                405                 410                 415     


His Cys Arg Val Leu Phe Leu Asp Tyr Val Met Phe Thr Ile His Met 
            420                 425                 430         


Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly Tyr 
        435                 440                 445             


Arg Ser His Asp Arg Tyr Glu Phe Ser Ser His Ile Ala Arg Gly Glu 
    450                 455                 460                 


His Arg Ala Leu Leu Lys 
465                 470 


<210>  1093
<211>  2152
<212>  DNA
<213>  Homosapiens

<400>  1093
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg     60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg    120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg    180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag    240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg    300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta    360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact    420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc    480

atactgcaag tgcggaggca agacacatca aagcagagat gggaagtgaa agagctctcg    540

tactggacag attagcaagc aatgtggcaa aacgaaaaag ctcaatgcct cagaaattca    600

ttggtgagaa gcgccactgc tttgatgtca actataattc aagttacatg tatgagaaag    660

agagtgagct catacagacc cgcatgatgg accaagccat caataacgcc atcagctatc    720

ttggcgccga agccctgcgc cccttggtcc agacaccgcc tgctcccacc tcggagatgg    780

ttccagttat cagcagcatg tatcccatag ccctcacccg ggctgagatg tcaaacggtg    840

cccctcaaga gctggaaaag aaaagcatcc accttccaga gaagagcgtg ccttctgaga    900

gaggcctctc tcccaacaat agtggccacg actccacgga cactgacagc aaccatgaag    960

aacgccagaa tcacatctat cagcaaaatc acatggtcct gtctcgggcc cgcaatggga   1020

tgccacttct gaaggaggtt ccccgctctt acgaactcct caagcccccg cccatctgcc   1080

caagagactc cgtcaaagtg atcaacaagg aaggggaggt gatggatgtg tatcggtgtg   1140

accactgccg cgtcctcttc ctggactatg tgatgttcac gattcacatg ggctgccacg   1200

gcttccgtga ccctttcgag tgtaacatgt gtggatatcg aagccatgat cggtatgagt   1260

tctcgtctca catagccaga ggagaacaca gagccctgct gaagtgaata tctggtctca   1320

gggattgctc ctatgtattc agcatcgttt ctaaaaacca atgacctcgc ctaacagatt   1380

gctctcaaaa catactcagt tccaaacttc ttttcatacc atttttagct gtgttcacag   1440

gggtagccag ggaaacactg tcttccttca gaaattattc gcaggtctag catattatta   1500

cttttgtgaa acctttgttt tcccatcagg gacttgaatt ttatggaatt taaaagccaa   1560

aaaggtattt ggtcattatc ttctacagca gtggaatgag tggtcccgga gatgtgctat   1620

atgaaacatt ctttctgaga tatatcaacc acacgtggaa aagcctttca gtcatacatg   1680

caaatccaca aagaggaaga gctgaccagc tgaccttgct gggaagcctc acccttctgc   1740

ccttcacagg ctgaagggtt aagatctaat ctccctaatc taaatgacag tctaagagta   1800

agtaaaagaa cagccataaa ataagtatct gttacgagta actgaagacc ccattctcca   1860

agcatcagat ccatttccta tcacaacatt tttaaaaaat gtcatctgat ggcacttctg   1920

cttctgtcct ttaccttccc atctccagtg aaaagctgag ctgctttggg ctaaaccagt   1980

tgtctataga agaaaatcta tgccagaaga actcatggtt ttaaatatag accatcatcg   2040

aaactccaga aatttatcca ctgtggatga tgacatcgct ttcctttggt caaggttggc   2100

agagcaaggg tataaagggg gaaattgttt ggcagcacca acagaaaaca aa           2152


<210>  1094
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  1094

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Ala Ser Ala 
    130                 135                 140                 


Glu Ala Arg His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val 
145                 150                 155                 160 


Leu Asp Arg Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro 
                165                 170                 175     


Gln Lys Phe Ile Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr Asn 
            180                 185                 190         


Ser Ser Tyr Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg Met 
        195                 200                 205             


Met Asp Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala 
    210                 215                 220                 


Leu Arg Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val 
225                 230                 235                 240 


Pro Val Ile Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu Met 
                245                 250                 255     


Ser Asn Gly Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu Pro 
            260                 265                 270         


Glu Lys Ser Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Gly 
        275                 280                 285             


His Asp Ser Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn His 
    290                 295                 300                 


Ile Tyr Gln Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly Met 
305                 310                 315                 320 


Pro Leu Leu Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro Pro 
                325                 330                 335     


Pro Ile Cys Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly Glu 
            340                 345                 350         


Val Met Asp Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu Asp 
        355                 360                 365             


Tyr Val Met Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro 
    370                 375                 380                 


Phe Glu Cys Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe 
385                 390                 395                 400 


Ser Ser His Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys 
                405                 410                 


<210>  1095
<211>  2203
<212>  DNA
<213>  Homosapiens

<400>  1095
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg     60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg    120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg    180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag    240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg    300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta    360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact    420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc    480

atactggtga acgcccattc cagtgtaatc agtgtggggc atcttttact cagaaaggta    540

acctcctccg ccacattaaa ctgcacacag gggaaaaacc ttttaagtgt cacctctgca    600

actatgcatg ccaaagaaga gatgcgctca cggggcatct taggacacat tctggtgaga    660

agcgccactg ctttgatgtc aactataatt caagttacat gtatgagaaa gagagtgagc    720

tcatacagac ccgcatgatg gaccaagcca tcaataacgc catcagctat cttggcgccg    780

aagccctgcg ccccttggtc cagacaccgc ctgctcccac ctcggagatg gttccagtta    840

tcagcagcat gtatcccata gccctcaccc gggctgagat gtcaaacggt gcccctcaag    900

agctggaaaa gaaaagcatc caccttccag agaagagcgt gccttctgag agaggcctct    960

ctcccaacaa tagtggccac gactccacgg acactgacag caaccatgaa gaacgccaga   1020

atcacatcta tcagcaaaat cacatggtcc tgtctcgggc ccgcaatggg atgccacttc   1080

tgaaggaggt tccccgctct tacgaactcc tcaagccccc gcccatctgc ccaagagact   1140

ccgtcaaagt gatcaacaag gaaggggagg tgatggatgt gtatcggtgt gaccactgcc   1200

gcgtcctctt cctggactat gtgatgttca cgattcacat gggctgccac ggcttccgtg   1260

accctttcga gtgtaacatg tgtggatatc gaagccatga tcggtatgag ttctcgtctc   1320

acatagccag aggagaacac agagccctgc tgaagtgaat atctggtctc agggattgct   1380

cctatgtatt cagcatcgtt tctaaaaacc aatgacctcg cctaacagat tgctctcaaa   1440

acatactcag ttccaaactt cttttcatac catttttagc tgtgttcaca ggggtagcca   1500

gggaaacact gtcttccttc agaaattatt cgcaggtcta gcatattatt acttttgtga   1560

aacctttgtt ttcccatcag ggacttgaat tttatggaat ttaaaagcca aaaaggtatt   1620

tggtcattat cttctacagc agtggaatga gtggtcccgg agatgtgcta tatgaaacat   1680

tctttctgag atatatcaac cacacgtgga aaagcctttc agtcatacat gcaaatccac   1740

aaagaggaag agctgaccag ctgaccttgc tgggaagcct cacccttctg cccttcacag   1800

gctgaagggt taagatctaa tctccctaat ctaaatgaca gtctaagagt aagtaaaaga   1860

acagccataa aataagtatc tgttacgagt aactgaagac cccattctcc aagcatcaga   1920

tccatttcct atcacaacat ttttaaaaaa tgtcatctga tggcacttct gcttctgtcc   1980

tttaccttcc catctccagt gaaaagctga gctgctttgg gctaaaccag ttgtctatag   2040

aagaaaatct atgccagaag aactcatggt tttaaatata gaccatcatc gaaactccag   2100

aaatttatcc actgtggatg atgacatcgc tttcctttgg tcaaggttgg cagagcaagg   2160

gtataaaggg ggaaattgtt tggcagcacc aacagaaaac aaa                     2203


<210>  1096
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  1096

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr 
        195                 200                 205             


Asn Ser Ser Tyr Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg 
    210                 215                 220                 


Met Met Asp Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu 
225                 230                 235                 240 


Ala Leu Arg Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met 
                245                 250                 255     


Val Pro Val Ile Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu 
            260                 265                 270         


Met Ser Asn Gly Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu 
        275                 280                 285             


Pro Glu Lys Ser Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser 
    290                 295                 300                 


Gly His Asp Ser Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn 
305                 310                 315                 320 


His Ile Tyr Gln Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly 
                325                 330                 335     


Met Pro Leu Leu Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro 
            340                 345                 350         


Pro Pro Ile Cys Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly 
        355                 360                 365             


Glu Val Met Asp Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu 
    370                 375                 380                 


Asp Tyr Val Met Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp 
385                 390                 395                 400 


Pro Phe Glu Cys Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu 
                405                 410                 415     


Phe Ser Ser His Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys 
            420                 425                 430     


<210>  1097
<211>  2437
<212>  DNA
<213>  Homosapiens

<400>  1097
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg     60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg    120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg    180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag    240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg    300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta    360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact    420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc    480

atactggtga acgcccattc cagtgtaatc agtgtggggc atcttttact cagaaaggta    540

acctcctccg ccacattaaa ctgcacacag gggaaaaacc ttttaagtgt cacctctgca    600

actatgcatg ccaaagaaga gatgcgctca cggggcatct taggacacat tctgtggaga    660

aaccctacaa atgtgagttt tgtggaagga gttacaagca gagaagttcc cttgaggagc    720

acaaggagcg ctgccgtaca tttcttcaga gcactgaccc aggggacact gcaagtgcgg    780

aggcaagaca catcaaagca gagatgggaa gtgaaagagc tctcgtactg gacagattag    840

caagcaatgt ggcaaaacga aaaagctcaa tgcctcagaa attcattggt gagaagcgcc    900

actgctttga tgtcaactat aattcaagtt acatgtatga gaaagagagt gagctcatac    960

agacccgcat gatggaccaa gccatcaata acgccatcag ctatcttggc gccgaagccc   1020

tgcgcccctt ggtccagaca ccgcctgctc ccacctcgga gatggttcca gttatcagca   1080

gcatgtatcc catagccctc acccgggctg agatgtcaaa cggtgcccct caagagctgg   1140

aaaagaaaag catccacctt ccagagaaga gcgtgccttc tgagagaggc ctctctccca   1200

acaatagtgg ccacgactcc acggacactg acagcaacca tgaagaacgc cagaatcaca   1260

tctatcagca aaatcacatg gtcctgtctc gggcccgcaa tgggatgcca cttctgaagg   1320

aggttccccg ctcttacgaa ctcctcaagc ccccgcccat ctgcccaaga gactccgtca   1380

aagtgatcaa caaggaaggg gaggtgatgg atgtgtatcg gtgtgaccac tgccgcgtcc   1440

tcttcctgga ctatgtgatg ttcacgattc acatgggctg ccacggcttc cgtgaccctt   1500

tcgagtgtaa catgtgtgga tatcgaagcc atgatcggta tgagttctcg tctcacatag   1560

ccagaggaga acacagagcc ctgctgaagt gaatatctgg tctcagggat tgctcctatg   1620

tattcagcat cgtttctaaa aaccaatgac ctcgcctaac agattgctct caaaacatac   1680

tcagttccaa acttcttttc ataccatttt tagctgtgtt cacaggggta gccagggaaa   1740

cactgtcttc cttcagaaat tattcgcagg tctagcatat tattactttt gtgaaacctt   1800

tgttttccca tcagggactt gaattttatg gaatttaaaa gccaaaaagg tatttggtca   1860

ttatcttcta cagcagtgga atgagtggtc ccggagatgt gctatatgaa acattctttc   1920

tgagatatat caaccacacg tggaaaagcc tttcagtcat acatgcaaat ccacaaagag   1980

gaagagctga ccagctgacc ttgctgggaa gcctcaccct tctgcccttc acaggctgaa   2040

gggttaagat ctaatctccc taatctaaat gacagtctaa gagtaagtaa aagaacagcc   2100

ataaaataag tatctgttac gagtaactga agaccccatt ctccaagcat cagatccatt   2160

tcctatcaca acatttttaa aaaatgtcat ctgatggcac ttctgcttct gtcctttacc   2220

ttcccatctc cagtgaaaag ctgagctgct ttgggctaaa ccagttgtct atagaagaaa   2280

atctatgcca gaagaactca tggttttaaa tatagaccat catcgaaact ccagaaattt   2340

atccactgtg gatgatgaca tcgctttcct ttggtcaagg ttggcagagc aagggtataa   2400

agggggaaat tgtttggcag caccaacaga aaacaaa                            2437


<210>  1098
<211>  509
<212>  PRT
<213>  Homosapiens

<400>  1098

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly 
        195                 200                 205             


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
    210                 215                 220                 


Arg Thr Phe Leu Gln Ser Thr Asp Pro Gly Asp Thr Ala Ser Ala Glu 
225                 230                 235                 240 


Ala Arg His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val Leu 
                245                 250                 255     


Asp Arg Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln 
            260                 265                 270         


Lys Phe Ile Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr Asn Ser 
        275                 280                 285             


Ser Tyr Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg Met Met 
    290                 295                 300                 


Asp Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala Leu 
305                 310                 315                 320 


Arg Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val Pro 
                325                 330                 335     


Val Ile Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu Met Ser 
            340                 345                 350         


Asn Gly Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu Pro Glu 
        355                 360                 365             


Lys Ser Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Gly His 
    370                 375                 380                 


Asp Ser Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn His Ile 
385                 390                 395                 400 


Tyr Gln Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly Met Pro 
                405                 410                 415     


Leu Leu Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro Pro Pro 
            420                 425                 430         


Ile Cys Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly Glu Val 
        435                 440                 445             


Met Asp Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu Asp Tyr 
    450                 455                 460                 


Val Met Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe 
465                 470                 475                 480 


Glu Cys Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe Ser 
                485                 490                 495     


Ser His Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys 
            500                 505                 


<210>  1099
<211>  2269
<212>  DNA
<213>  Homosapiens

<400>  1099
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg     60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg    120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg    180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag    240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg    300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta    360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact    420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc    480

atactgtgga gaaaccctac aaatgtgagt tttgtggaag gagttacaag cagagaagtt    540

cccttgagga gcacaaggag cgctgccgta catttcttca gagcactgac ccaggggaca    600

ctgcaagtgc ggaggcaaga cacatcaaag cagagatggg aagtgaaaga gctctcgtac    660

tggacagatt agcaagcaat gtggcaaaac gaaaaagctc aatgcctcag aaattcattg    720

gtgagaagcg ccactgcttt gatgtcaact ataattcaag ttacatgtat gagaaagaga    780

gtgagctcat acagacccgc atgatggacc aagccatcaa taacgccatc agctatcttg    840

gcgccgaagc cctgcgcccc ttggtccaga caccgcctgc tcccacctcg gagatggttc    900

cagttatcag cagcatgtat cccatagccc tcacccgggc tgagatgtca aacggtgccc    960

ctcaagagct ggaaaagaaa agcatccacc ttccagagaa gagcgtgcct tctgagagag   1020

gcctctctcc caacaatagt ggccacgact ccacggacac tgacagcaac catgaagaac   1080

gccagaatca catctatcag caaaatcaca tggtcctgtc tcgggcccgc aatgggatgc   1140

cacttctgaa ggaggttccc cgctcttacg aactcctcaa gcccccgccc atctgcccaa   1200

gagactccgt caaagtgatc aacaaggaag gggaggtgat ggatgtgtat cggtgtgacc   1260

actgccgcgt cctcttcctg gactatgtga tgttcacgat tcacatgggc tgccacggct   1320

tccgtgaccc tttcgagtgt aacatgtgtg gatatcgaag ccatgatcgg tatgagttct   1380

cgtctcacat agccagagga gaacacagag ccctgctgaa gtgaatatct ggtctcaggg   1440

attgctccta tgtattcagc atcgtttcta aaaaccaatg acctcgccta acagattgct   1500

ctcaaaacat actcagttcc aaacttcttt tcataccatt tttagctgtg ttcacagggg   1560

tagccaggga aacactgtct tccttcagaa attattcgca ggtctagcat attattactt   1620

ttgtgaaacc tttgttttcc catcagggac ttgaatttta tggaatttaa aagccaaaaa   1680

ggtatttggt cattatcttc tacagcagtg gaatgagtgg tcccggagat gtgctatatg   1740

aaacattctt tctgagatat atcaaccaca cgtggaaaag cctttcagtc atacatgcaa   1800

atccacaaag aggaagagct gaccagctga ccttgctggg aagcctcacc cttctgccct   1860

tcacaggctg aagggttaag atctaatctc cctaatctaa atgacagtct aagagtaagt   1920

aaaagaacag ccataaaata agtatctgtt acgagtaact gaagacccca ttctccaagc   1980

atcagatcca tttcctatca caacattttt aaaaaatgtc atctgatggc acttctgctt   2040

ctgtccttta ccttcccatc tccagtgaaa agctgagctg ctttgggcta aaccagttgt   2100

ctatagaaga aaatctatgc cagaagaact catggtttta aatatagacc atcatcgaaa   2160

ctccagaaat ttatccactg tggatgatga catcgctttc ctttggtcaa ggttggcaga   2220

gcaagggtat aaagggggaa attgtttggc agcaccaaca gaaaacaaa               2269


<210>  1100
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  1100

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Val Glu Lys 
    130                 135                 140                 


Pro Tyr Lys Cys Glu Phe Cys Gly Arg Ser Tyr Lys Gln Arg Ser Ser 
145                 150                 155                 160 


Leu Glu Glu His Lys Glu Arg Cys Arg Thr Phe Leu Gln Ser Thr Asp 
                165                 170                 175     


Pro Gly Asp Thr Ala Ser Ala Glu Ala Arg His Ile Lys Ala Glu Met 
            180                 185                 190         


Gly Ser Glu Arg Ala Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala 
        195                 200                 205             


Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Ile Gly Glu Lys Arg His 
    210                 215                 220                 


Cys Phe Asp Val Asn Tyr Asn Ser Ser Tyr Met Tyr Glu Lys Glu Ser 
225                 230                 235                 240 


Glu Leu Ile Gln Thr Arg Met Met Asp Gln Ala Ile Asn Asn Ala Ile 
                245                 250                 255     


Ser Tyr Leu Gly Ala Glu Ala Leu Arg Pro Leu Val Gln Thr Pro Pro 
            260                 265                 270         


Ala Pro Thr Ser Glu Met Val Pro Val Ile Ser Ser Met Tyr Pro Ile 
        275                 280                 285             


Ala Leu Thr Arg Ala Glu Met Ser Asn Gly Ala Pro Gln Glu Leu Glu 
    290                 295                 300                 


Lys Lys Ser Ile His Leu Pro Glu Lys Ser Val Pro Ser Glu Arg Gly 
305                 310                 315                 320 


Leu Ser Pro Asn Asn Ser Gly His Asp Ser Thr Asp Thr Asp Ser Asn 
                325                 330                 335     


His Glu Glu Arg Gln Asn His Ile Tyr Gln Gln Asn His Met Val Leu 
            340                 345                 350         


Ser Arg Ala Arg Asn Gly Met Pro Leu Leu Lys Glu Val Pro Arg Ser 
        355                 360                 365             


Tyr Glu Leu Leu Lys Pro Pro Pro Ile Cys Pro Arg Asp Ser Val Lys 
    370                 375                 380                 


Val Ile Asn Lys Glu Gly Glu Val Met Asp Val Tyr Arg Cys Asp His 
385                 390                 395                 400 


Cys Arg Val Leu Phe Leu Asp Tyr Val Met Phe Thr Ile His Met Gly 
                405                 410                 415     


Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly Tyr Arg 
            420                 425                 430         


Ser His Asp Arg Tyr Glu Phe Ser Ser His Ile Ala Arg Gly Glu His 
        435                 440                 445             


Arg Ala Leu Leu Lys 
    450             


<210>  1101
<211>  2320
<212>  DNA
<213>  Homosapiens

<400>  1101
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg     60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg    120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg    180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag    240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg    300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta    360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact    420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc    480

atactggtga acgcccattc cagtgtaatc agtgtggggc atcttttact cagaaaggta    540

acctcctccg ccacattaaa ctgcacacag gggaaaaacc ttttaagtgt cacctctgca    600

actatgcatg ccaaagaaga gatgcgctca cggggcatct taggacacat tctgtggaga    660

aaccctacaa atgtgagttt tgtggaagga gttacaagca gagaagttcc cttgaggagc    720

acaaggagcg ctgccgtaca tttcttcaga gcactgaccc aggggacact ggtgagaagc    780

gccactgctt tgatgtcaac tataattcaa gttacatgta tgagaaagag agtgagctca    840

tacagacccg catgatggac caagccatca ataacgccat cagctatctt ggcgccgaag    900

ccctgcgccc cttggtccag acaccgcctg ctcccacctc ggagatggtt ccagttatca    960

gcagcatgta tcccatagcc ctcacccggg ctgagatgtc aaacggtgcc cctcaagagc   1020

tggaaaagaa aagcatccac cttccagaga agagcgtgcc ttctgagaga ggcctctctc   1080

ccaacaatag tggccacgac tccacggaca ctgacagcaa ccatgaagaa cgccagaatc   1140

acatctatca gcaaaatcac atggtcctgt ctcgggcccg caatgggatg ccacttctga   1200

aggaggttcc ccgctcttac gaactcctca agcccccgcc catctgccca agagactccg   1260

tcaaagtgat caacaaggaa ggggaggtga tggatgtgta tcggtgtgac cactgccgcg   1320

tcctcttcct ggactatgtg atgttcacga ttcacatggg ctgccacggc ttccgtgacc   1380

ctttcgagtg taacatgtgt ggatatcgaa gccatgatcg gtatgagttc tcgtctcaca   1440

tagccagagg agaacacaga gccctgctga agtgaatatc tggtctcagg gattgctcct   1500

atgtattcag catcgtttct aaaaaccaat gacctcgcct aacagattgc tctcaaaaca   1560

tactcagttc caaacttctt ttcataccat ttttagctgt gttcacaggg gtagccaggg   1620

aaacactgtc ttccttcaga aattattcgc aggtctagca tattattact tttgtgaaac   1680

ctttgttttc ccatcaggga cttgaatttt atggaattta aaagccaaaa aggtatttgg   1740

tcattatctt ctacagcagt ggaatgagtg gtcccggaga tgtgctatat gaaacattct   1800

ttctgagata tatcaaccac acgtggaaaa gcctttcagt catacatgca aatccacaaa   1860

gaggaagagc tgaccagctg accttgctgg gaagcctcac ccttctgccc ttcacaggct   1920

gaagggttaa gatctaatct ccctaatcta aatgacagtc taagagtaag taaaagaaca   1980

gccataaaat aagtatctgt tacgagtaac tgaagacccc attctccaag catcagatcc   2040

atttcctatc acaacatttt taaaaaatgt catctgatgg cacttctgct tctgtccttt   2100

accttcccat ctccagtgaa aagctgagct gctttgggct aaaccagttg tctatagaag   2160

aaaatctatg ccagaagaac tcatggtttt aaatatagac catcatcgaa actccagaaa   2220

tttatccact gtggatgatg acatcgcttt cctttggtca aggttggcag agcaagggta   2280

taaaggggga aattgtttgg cagcaccaac agaaaacaaa                         2320


<210>  1102
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  1102

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly 
        195                 200                 205             


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
    210                 215                 220                 


Arg Thr Phe Leu Gln Ser Thr Asp Pro Gly Asp Thr Gly Glu Lys Arg 
225                 230                 235                 240 


His Cys Phe Asp Val Asn Tyr Asn Ser Ser Tyr Met Tyr Glu Lys Glu 
                245                 250                 255     


Ser Glu Leu Ile Gln Thr Arg Met Met Asp Gln Ala Ile Asn Asn Ala 
            260                 265                 270         


Ile Ser Tyr Leu Gly Ala Glu Ala Leu Arg Pro Leu Val Gln Thr Pro 
        275                 280                 285             


Pro Ala Pro Thr Ser Glu Met Val Pro Val Ile Ser Ser Met Tyr Pro 
    290                 295                 300                 


Ile Ala Leu Thr Arg Ala Glu Met Ser Asn Gly Ala Pro Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Lys Ser Ile His Leu Pro Glu Lys Ser Val Pro Ser Glu Arg 
                325                 330                 335     


Gly Leu Ser Pro Asn Asn Ser Gly His Asp Ser Thr Asp Thr Asp Ser 
            340                 345                 350         


Asn His Glu Glu Arg Gln Asn His Ile Tyr Gln Gln Asn His Met Val 
        355                 360                 365             


Leu Ser Arg Ala Arg Asn Gly Met Pro Leu Leu Lys Glu Val Pro Arg 
    370                 375                 380                 


Ser Tyr Glu Leu Leu Lys Pro Pro Pro Ile Cys Pro Arg Asp Ser Val 
385                 390                 395                 400 


Lys Val Ile Asn Lys Glu Gly Glu Val Met Asp Val Tyr Arg Cys Asp 
                405                 410                 415     


His Cys Arg Val Leu Phe Leu Asp Tyr Val Met Phe Thr Ile His Met 
            420                 425                 430         


Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly Tyr 
        435                 440                 445             


Arg Ser His Asp Arg Tyr Glu Phe Ser Ser His Ile Ala Arg Gly Glu 
    450                 455                 460                 


His Arg Ala Leu Leu Lys 
465                 470 


<210>  1103
<211>  1426
<212>  DNA
<213>  Homosapiens

<400>  1103
gttgcgacgg acgggtaggg gaggcgaccc cggcgttctg ctccgcactg tggaggaggt     60

ggggaggtgt tgggccaggg ctgaggtagg agggagtctg tccctcgacg cctcctgcga    120

cgccagcccc tgagcgatga tgcgaacgtg cgtcctactc tccgcggtgc tctggtgcct    180

cacaggagtc caatgcccgc gttttacctt attcaataag aagggcttca tttatggcaa    240

gacaggacag ccagacaaaa tatatgtaga gttacatcaa aatagtccag tccttatctg    300

tatggatttt aagctttcta aaaaagaaat agtggacccc acctacttat ggattgggcc    360

taatgaaaag acgttaacag gaaataatag aataaatata actgaaactg gacagctgat    420

ggtgaaagat tttttggagc ctttgtctgg actttacaca tgtactcttt cttataagac    480

tgttaaagca gaaactcaag aagaaaaaac agtcaaaaag agatatgact ttatggtctt    540

tgcctatcgg gaacctgatt attcatatca gatggctgta cgttttacca caaggtcttg    600

tatagggaga tacaatgatg tattctttag agtgctgaag aaaatcttgg atagtctaat    660

ttctgatttg tcatgccatg tcatagagcc atcatataaa tgccattctg ttgaaattcc    720

agaacatggc ctcatacatg agctatttat agcatttcaa gttaatcctt ttgcgccggg    780

gtggaaaggt gcttgcaatg gatctgttga ctgtgaagat accactaatc ataatatcct    840

ccaggcaaga gatcgaatag aagacttttt tcggagccaa gcatatattt tctaccataa    900

ctttaataaa actctaccag caatgcattt tgtggaccac agtttgcaag tagtacgtct    960

ggatagctgt cgaccaggct ttggaaaaaa tgaacgtcta cacagtaatt gcgctagctg   1020

ttgtgtggtt tgtagtcctg cgacttttag tcctgatgtt aatgtaactt gtcagacctg   1080

cgtttccgtc cttacctatg gagctaaatc ttgcccacaa acttcaaaca aaaatcagca   1140

atatgaagat tagaggtgaa agcattgtta cttacttgtg gaagtcgggg acataagatg   1200

attttcacat cccagagcat catagatagt tccattaagt aaaatcagta agaccaaacc   1260

actggaaaac atgcattttg gaaactttaa aataaatggt taacatggca tttctaagaa   1320

ggcatttaat ccagtatctc tagtgtacaa aggaaacttg aagttttaat ggattatttt   1380

taatgaaatg ttttattgtt tacaaacggt atgttgctgt gtacct                  1426


<210>  1104
<211>  338
<212>  PRT
<213>  Homosapiens

<400>  1104

Met Met Arg Thr Cys Val Leu Leu Ser Ala Val Leu Trp Cys Leu Thr 
1               5                   10                  15      


Gly Val Gln Cys Pro Arg Phe Thr Leu Phe Asn Lys Lys Gly Phe Ile 
            20                  25                  30          


Tyr Gly Lys Thr Gly Gln Pro Asp Lys Ile Tyr Val Glu Leu His Gln 
        35                  40                  45              


Asn Ser Pro Val Leu Ile Cys Met Asp Phe Lys Leu Ser Lys Lys Glu 
    50                  55                  60                  


Ile Val Asp Pro Thr Tyr Leu Trp Ile Gly Pro Asn Glu Lys Thr Leu 
65                  70                  75                  80  


Thr Gly Asn Asn Arg Ile Asn Ile Thr Glu Thr Gly Gln Leu Met Val 
                85                  90                  95      


Lys Asp Phe Leu Glu Pro Leu Ser Gly Leu Tyr Thr Cys Thr Leu Ser 
            100                 105                 110         


Tyr Lys Thr Val Lys Ala Glu Thr Gln Glu Glu Lys Thr Val Lys Lys 
        115                 120                 125             


Arg Tyr Asp Phe Met Val Phe Ala Tyr Arg Glu Pro Asp Tyr Ser Tyr 
    130                 135                 140                 


Gln Met Ala Val Arg Phe Thr Thr Arg Ser Cys Ile Gly Arg Tyr Asn 
145                 150                 155                 160 


Asp Val Phe Phe Arg Val Leu Lys Lys Ile Leu Asp Ser Leu Ile Ser 
                165                 170                 175     


Asp Leu Ser Cys His Val Ile Glu Pro Ser Tyr Lys Cys His Ser Val 
            180                 185                 190         


Glu Ile Pro Glu His Gly Leu Ile His Glu Leu Phe Ile Ala Phe Gln 
        195                 200                 205             


Val Asn Pro Phe Ala Pro Gly Trp Lys Gly Ala Cys Asn Gly Ser Val 
    210                 215                 220                 


Asp Cys Glu Asp Thr Thr Asn His Asn Ile Leu Gln Ala Arg Asp Arg 
225                 230                 235                 240 


Ile Glu Asp Phe Phe Arg Ser Gln Ala Tyr Ile Phe Tyr His Asn Phe 
                245                 250                 255     


Asn Lys Thr Leu Pro Ala Met His Phe Val Asp His Ser Leu Gln Val 
            260                 265                 270         


Val Arg Leu Asp Ser Cys Arg Pro Gly Phe Gly Lys Asn Glu Arg Leu 
        275                 280                 285             


His Ser Asn Cys Ala Ser Cys Cys Val Val Cys Ser Pro Ala Thr Phe 
    290                 295                 300                 


Ser Pro Asp Val Asn Val Thr Cys Gln Thr Cys Val Ser Val Leu Thr 
305                 310                 315                 320 


Tyr Gly Ala Lys Ser Cys Pro Gln Thr Ser Asn Lys Asn Gln Gln Tyr 
                325                 330                 335     


Glu Asp 
        


<210>  1105
<211>  2191
<212>  DNA
<213>  Homosapiens

<400>  1105
gccgttgcga cggacgggta ggggaggcga ccccggcgtt ctgctccgca ctgtggagga     60

ggtggggagg tgttgggcca gggctgaggt aggagggagt ctgtccctcg acgcctcctg    120

cgacgccagc ccctgagcga tgatgcgaac gtgcgtccta ctctccgcgg tgctctggtg    180

cctcacagga gacaaaatat atgtagagtt acatcaaaat agtccagtcc ttatctgtat    240

ggattttaag ctttctaaaa aagaaatagt ggaccccacc tacttatgga ttgggcctaa    300

tgaaaagacg ttaacaggaa ataatagaat aaatataact gaaactggac agctgatggt    360

gaaagatttt ttggagcctt tgtctggact ttacacatgt actctttctt ataagactgt    420

taaagcagaa actcaagaag aaaaaacagt caaaaagaga tatgacttta tggtctttgc    480

ctatcgggaa cctgattatt catatcagat ggctgtacgt tttaccacaa ggtcttgtat    540

agggagatac aatgatgtat tctttagagt gctgaagaaa atcttggata gtctaatttc    600

tgatttgtca tgccatgtca tagagccatc atataaatgc cattctgttg aaattccaga    660

acatggcctc atacatgagc tatttatagc atttcaagtt aatccttttg cgccggggtg    720

gaaaggtgct tgcaatggat ctgttgactg tgaagatacc actaatcata atatcctcca    780

ggcaagagat cgaatagaag acttttttcg gagccaagca tatattttct accataactt    840

taataaaact ctaccagcaa tgcattttgt ggaccacagt ttgcaagtag tacgtctgga    900

tagctgtcga ccaggctttg gaaaaaatga acgtctacac agtaattgcg ctagctgttg    960

tgtggtttgt agtcctgcga cttttagtcc tgatgttaat gtaacttgtc agacctgcgt   1020

ttccgtcctt acctatggag ctaaatcttg cccacaaact tcaaacaaaa atcagcaata   1080

tgaagattag aggtgaaagc attgttactt acttgtggaa gtcggggaca taagatgatt   1140

ttcacatccc agagcatcat agatagttcc attaagtaaa atcagtaaga ccaaaccact   1200

ggaaaacatg cattttggaa actttaaaat aaatggttaa catggcattt ctaagaaggc   1260

atttaatcca gtatctctag tgtacaaagg aaacttgaag ttttaatgga ttatttttaa   1320

tgaaatgttt tattgtttac aaacggtatg ttgctgtgta cctaagagta tagtaaggtc   1380

aagaagagta tcaaagtata ataaaataaa aattgtatac tctccatata tttatttgtt   1440

tggaatcact cttgtgtgat ataaaggcgt gtatattatc tttgtattag aaccaaaaaa   1500

gttatttatt ttggtcccta tgattttatt ttttaagata aattaatata ctgtattttt   1560

taaagtatag gtttaggttt acagaataat agagcagata atatatagag ttccatacac   1620

ccactgcacc ccataccctc attcctcctt acacaatttc tcctattatt aagatggtgc   1680

attagtgtgg cacatttgtt acaaatgatg aaccaatatt aatttattat taattatagc   1740

ccatagttca cattaagatt cattgtgttg taaggttatg tgggttttga caaattcata   1800

atggcatgtg tgcaccattg cagtctcata cagaatagtt tcaccaccct caaaatcctg   1860

tgcttcactt atttatccct cccgccgtgc cctggcaacc actgatcttt ttactgtctc   1920

tacagttttg ccttttccaa aatgtcatgt agttggttgg agttatgcag tatgtagact   1980

ttttagactg gcttctttca cttagcaata tgcatttaag gttcctccat gtctttttgt   2040

gacttgatag ctcatttttt attgctgaat aatgttcatt gtatggatat agcatagtat   2100

gtttatccat tcgcccatta aaggaaatct tgattgcttc cagttttcag tgattaaaaa   2160

taaagccgct ataaacaaaa aaaaaaaaaa a                                  2191


<210>  1106
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  1106

Met Arg Thr Cys Val Leu Leu Ser Ala Val Leu Trp Cys Leu Thr Gly 
1               5                   10                  15      


Asp Lys Ile Tyr Val Glu Leu His Gln Asn Ser Pro Val Leu Ile Cys 
            20                  25                  30          


Met Asp Phe Lys Leu Ser Lys Lys Glu Ile Val Asp Pro Thr Tyr Leu 
        35                  40                  45              


Trp Ile Gly Pro Asn Glu Lys Thr Leu Thr Gly Asn Asn Arg Ile Asn 
    50                  55                  60                  


Ile Thr Glu Thr Gly Gln Leu Met Val Lys Asp Phe Leu Glu Pro Leu 
65                  70                  75                  80  


Ser Gly Leu Tyr Thr Cys Thr Leu Ser Tyr Lys Thr Val Lys Ala Glu 
                85                  90                  95      


Thr Gln Glu Glu Lys Thr Val Lys Lys Arg Tyr Asp Phe Met Val Phe 
            100                 105                 110         


Ala Tyr Arg Glu Pro Asp Tyr Ser Tyr Gln Met Ala Val Arg Phe Thr 
        115                 120                 125             


Thr Arg Ser Cys Ile Gly Arg Tyr Asn Asp Val Phe Phe Arg Val Leu 
    130                 135                 140                 


Lys Lys Ile Leu Asp Ser Leu Ile Ser Asp Leu Ser Cys His Val Ile 
145                 150                 155                 160 


Glu Pro Ser Tyr Lys Cys His Ser Val Glu Ile Pro Glu His Gly Leu 
                165                 170                 175     


Ile His Glu Leu Phe Ile Ala Phe Gln Val Asn Pro Phe Ala Pro Gly 
            180                 185                 190         


Trp Lys Gly Ala Cys Asn Gly Ser Val Asp Cys Glu Asp Thr Thr Asn 
        195                 200                 205             


His Asn Ile Leu Gln Ala Arg Asp Arg Ile Glu Asp Phe Phe Arg Ser 
    210                 215                 220                 


Gln Ala Tyr Ile Phe Tyr His Asn Phe Asn Lys Thr Leu Pro Ala Met 
225                 230                 235                 240 


His Phe Val Asp His Ser Leu Gln Val Val Arg Leu Asp Ser Cys Arg 
                245                 250                 255     


Pro Gly Phe Gly Lys Asn Glu Arg Leu His Ser Asn Cys Ala Ser Cys 
            260                 265                 270         


Cys Val Val Cys Ser Pro Ala Thr Phe Ser Pro Asp Val Asn Val Thr 
        275                 280                 285             


Cys Gln Thr Cys Val Ser Val Leu Thr Tyr Gly Ala Lys Ser Cys Pro 
    290                 295                 300                 


Gln Thr Ser Asn Lys Asn Gln Gln Tyr Glu Asp 
305                 310                 315 


<210>  1107
<211>  2573
<212>  DNA
<213>  Homosapiens

<400>  1107
agaaagttgt gcgcagggac tgggggcggg cggccaggca ggagaggacc ccgccggacc     60

agccgccctg aacgctgcgc ccggcgccct ggacctgatc ctgcgaatcc gcgctttcgg    120

tgcgagggac ctggctagcc gctgcctccc tccctacctc tgggtgacac caggtttggg    180

ggattttttt gaccaggcga aagtgggagt cgctggcgtc ctggccatga acacagcctc    240

gcgttcttct cagcctggga aggaccttct gcctctgtaa ctcgtccctg ccgcaagcca    300

gacaggactg gcacccgcgc cgctgggcac ccgccaccct tgtggcttct ctttgagtcc    360

cctctttttg ttcctgctcc gtggtttagc tggtggtgct tgagtttggg gtgagaattt    420

attattatta ttattttttg ccttgaggtg tgaatgtgag ggtttgatga ctttcagatg    480

tctaggaacc agagtgggtg caggggcccc aggcagggct gattcttggg cggaggagag    540

tagggtaaag ggttctgcat gagctcctta aaggacaaag gtaacagagc cagcgagaga    600

gctcgagggg agactttgac ttcaagccac agaattggtg gaagtgtgcg cgccgccgcc    660

gccgtcgctc ctgcagcgct gtcgacctag ccgctagcat cttcccgagc accgggatcc    720

cggggtagga ggcgacgcgg gcgagcacca gcgccagccg gctgcggctg cccacacggc    780

tcaccatggg ctccgggcgc cgggcgctgt ccgcggtgcc ggccgtgctg ctggtcctca    840

cgctgccggg gctgcccgtc tgggcacaga acgacacgga gcccatcgtg ctggagggca    900

agtgtctggt ggtgtgcgac tcgaacccgg ccacggactc caagggctcc tcttcctccc    960

cgctggggat atcggtccgg gcggccaact ccaaggtcgc cttctcggcg gtgcggagca   1020

ccaaccacga gccatccgag atgagcaaca agacgcgcat catttacttc gatcagatcc   1080

tggtgaatgt gggtaatttt ttcacattgg agtctgtctt tgtagcacca agaaaaggaa   1140

tttacagttt cagttttcac gtgattaaag tctaccagag ccaaactatc caggttaact   1200

tgatgttaaa tggaaaacca gtaatatctg cctttgcggg ggacaaagat gttactcgtg   1260

aagctgccac gaatggtgtc ctgctctacc tagataaaga ggataaggtt tacctaaaac   1320

tggagaaagg taatttggtt ggaggctggc agtattccac gttttctggc tttctggtgt   1380

tccccctata ggattcaatt tctccatgat gttcatccag gtgagggatg acccactcct   1440

gagttattgg aagatcattt tttcatcatt ggattgatgt cttttattgg tttctcatgg   1500

gtggatatgg attctaagga ttctagcctg tctgaaccaa tacaaaattt cacagattat   1560

ttgtgtgtgt ctgtttcagt atatttggat tgggactcta agcagataat acctatgctt   1620

aaatgtaaca gtcaaaagct gtctgcaaga cttattctga atttcatttc ctgggattac   1680

tgaattagtt acagatgtgg aattttattt gtttagtttt aaaagactgg caaccaggtc   1740

taaggattag aaaactctaa agttctgact tcaatcaacg gttagtgtga tactgccaaa   1800

gaactgtata ctgtgttaat atattgatta tatttgtttt tattcctttg gaattagttt   1860

gtttggttct tgtaaaaaac ttggattttt tttttcagta actggtatta tgttttctct   1920

taaaataagg taatgaatgg cttgcccaca aatttacctt gactacgata tcatcgacat   1980

gacttctctc aaaaaaaaag aatgcttcat agttgtattt taattgtata tgtgaaagag   2040

tcatattttc caagttatat tttctaagaa gaagaataga tcataaatct gacaaggaaa   2100

aagttgctta cccaaaatct aagtgctcaa tccctgagcc tcagcaaaac agctcccctc   2160

cgagggaaat cttatacttt attgctcaac tttaattaaa atgattgata ataaccactt   2220

tattaaaaac ctaaggtttt ttttttttcc gtagacatga ccactttatt aactggtggt   2280

gggatgctgt tgtttctaat tatacctatt tttcaaggct tctgttgtat ttgaagtatc   2340

atctggtttt gccttaactc tttaaattgt atatatttat ctgtttagct aatattaaat   2400

tcaaatatcc catatctaaa tttagtgcaa tatcttgtct tttgtatagg tcatatgaat   2460

tcataaaatt atttatgtct gttatagaat aaagattaat atatgttaaa aaaaaaaaaa   2520

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagaaa aaaaaaaaaa aaa          2573


<210>  1108
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1108

Met Gly Ser Gly Arg Arg Ala Leu Ser Ala Val Pro Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Thr Leu Pro Gly Leu Pro Val Trp Ala Gln Asn Asp Thr Glu 
            20                  25                  30          


Pro Ile Val Leu Glu Gly Lys Cys Leu Val Val Cys Asp Ser Asn Pro 
        35                  40                  45              


Ala Thr Asp Ser Lys Gly Ser Ser Ser Ser Pro Leu Gly Ile Ser Val 
    50                  55                  60                  


Arg Ala Ala Asn Ser Lys Val Ala Phe Ser Ala Val Arg Ser Thr Asn 
65                  70                  75                  80  


His Glu Pro Ser Glu Met Ser Asn Lys Thr Arg Ile Ile Tyr Phe Asp 
                85                  90                  95      


Gln Ile Leu Val Asn Val Gly Asn Phe Phe Thr Leu Glu Ser Val Phe 
            100                 105                 110         


Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser Phe His Val Ile Lys 
        115                 120                 125             


Val Tyr Gln Ser Gln Thr Ile Gln Val Asn Leu Met Leu Asn Gly Lys 
    130                 135                 140                 


Pro Val Ile Ser Ala Phe Ala Gly Asp Lys Asp Val Thr Arg Glu Ala 
145                 150                 155                 160 


Ala Thr Asn Gly Val Leu Leu Tyr Leu Asp Lys Glu Asp Lys Val Tyr 
                165                 170                 175     


Leu Lys Leu Glu Lys Gly Asn Leu Val Gly Gly Trp Gln Tyr Ser Thr 
            180                 185                 190         


Phe Ser Gly Phe Leu Val Phe Pro Leu 
        195                 200     


<210>  1109
<211>  845
<212>  DNA
<213>  Homosapiens

<400>  1109
ggggggcatc agcgatggcg gctgcgtcgg ggtcggttct gcagcgctgt atcgtgtcgc     60

cggcagggag gcatagcgcc tctctgatct tcctgcatgg ctcaggtgat tctggacaag    120

gattaagaat gtggatcaag caggttttaa atcaagattt aacattccaa cacataaaaa    180

ttatttatcc aacagctcct cccagatcat atactcctat gaaaggagga atctccaatg    240

tatggtttga cagatttaaa ataaccaatg actgcccaga acaccttgaa tcaattgatg    300

tcatgtgtca agtgcttact gatttgattg atgaagaagt aaaaagtggc atcaagaaga    360

acaggatatt aataggagga ttctctatgg gaggatgcat ggcaatgcat ttagcatata    420

gaaatcatca agatgtggca ggagtatttg ctctttctag ttttctgaat aaagcatctg    480

ctgtttacca ggctcttcag aagagtaatg gtgtacttcc tgaattattt cagtgtcatg    540

gtactgcaga tgagttagtt cttcattctt gggcagaaga gacaaactca atgttaaaat    600

ctctaggagt gaccacgaag tttcatagtt ttccaaatgt ttaccatgag ctaagcaaaa    660

ctgagttaga catattgaag ttatggattc ttacaaagct gccaggagaa atggaaaaac    720

aaaaatgaat gaatcaagag tgatttgtta atgtaagtgt aatgtctttg tgaaaagtga    780

tttttactgc caaattataa tgataattaa aatattaaaa aaaaaaaaaa aaaaaaaaaa    840

aaaaa                                                                845


<210>  1110
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  1110

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg 
65                  70                  75                  80  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
                85                  90                  95      


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
            100                 105                 110         


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
        115                 120                 125             


Met Ala Met His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
    130                 135                 140                 


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
145                 150                 155                 160 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
                165                 170                 175     


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
            180                 185                 190         


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
        195                 200                 205             


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
    210                 215                 220                 


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
225                 230                 235         


<210>  1111
<211>  1887
<212>  DNA
<213>  Homosapiens

<400>  1111
caagaatata tattgaatct tttccaacgt tatgttgatg aaggtttaca ttttatcaat     60

aaaaagtgca gccaagcaat tccacaagtg gacatcagca aagttactac actctgttgc    120

ttattggagt ccttgatact tgggaaagat ggagttaact tggcaatgga acaaacaaaa    180

ttgaacacta tactatgtca gacttttgta ttctgttatt tgtggtcttt gggtggaaac    240

ctaactgaaa actactatga ttcttttgat acatttatta gaacacaatt tgatgataat    300

cctgatgcca ggcttcccaa ttctggtgat ctgtggagca ttcatatgga ctttgacacc    360

aaacggctgg atccctggga acgaatcata cctactttca aatacaaccg agatgttcca    420

ttttttgaaa tgcttgtccc cacaactgac acagtgcgct atgggtatct aatggaaaaa    480

ctactggcag tcaagcattc cgtgttgttt actggaataa ctggagtggg caagtctgtg    540

attgcaaaag gattgctaaa taaaattcaa gaatcagctg gctatgtccc tgtttatctg    600

aatttttctg ctcaaacttc atctgcaagg acacaagaga tcattgagtc aaaactggag    660

agaaaaagaa aaaatattct aggagcaccg ggaaacaaac gaattgtgat ttttgttgat    720

gatttaaaca tgcccagact ggatcgctat ggctctcagc ctccgattga attacttcgg    780

cagtatcaag attttggggg attttatgac agaaacaaac tgttttggaa agaaatacag    840

gatgtaacaa tcatatcggc atgtgcacct ccaggcggtg gccgcaaccc tgtgactccc    900

cgcttcatca gacacttcag catgctgtgc ctcccaatgc cctcagagca cagtctgaaa    960

cagatttttc aggccatctt aaatggtttc ctgagtgact ttccaccagc tgtaaagcaa   1020

actgcatcaa gcattgtaga agcctcagtt gagatttata acaaaatgag tgttgacctc   1080

ctgccaacac ccgccaagtc ccattatgtc tttaacttga gggacttatc caaatgtgtg   1140

caagacaaac attttggaat tgcaattgac ctggaatatt ttttgaataa gcccatcata   1200

tttggagatt tcattaagtt tggagcagat aaagctgatc ggatttatga tgacatgcct   1260

gatatagaga aaactgcaaa tgttctacag gactatcttg atgattataa tctcacaaat   1320

cccaaagaag taaagttggt gttcttccag gatgctatag aacatgtttc aaggattgct   1380

cggatgatac gtcaagaaag aggcaatgcc ctgcttgttg gagtaggagg cacaggaaag   1440

cagtcactca cgagacttgc agctcatata tgcggttaca aatgtttgca gattgaactc   1500

agccggggat ataattatga tagttttcat gaagacctga ggaagttgta caaaatggct   1560

ggtgtagaag acaagaatat ggttttcctt ttcactgaca cccagattgt agtggaggag   1620

ttcctagaag atataaataa catcctgaac tcaggtgaag tgcctaattt atttgaaaag   1680

gatgaactgg agcaggtttt agcggccacc agaccaagag caaaagaagt aggaatttct   1740

gaggggaaca gagacgaggt aggatgtgcc agagtagtta tgtggcttta tcacaaaaac   1800

gtttcttcac cttttattta accattcatt gattgcctga aggggtccat gaataaaatt   1860

tttttcaata taaaaaaaaa aaaaaaa                                       1887


<210>  1112
<211>  551
<212>  PRT
<213>  Homosapiens

<400>  1112

Met Glu Gln Thr Lys Leu Asn Thr Ile Leu Cys Gln Thr Phe Val Phe 
1               5                   10                  15      


Cys Tyr Leu Trp Ser Leu Gly Gly Asn Leu Thr Glu Asn Tyr Tyr Asp 
            20                  25                  30          


Ser Phe Asp Thr Phe Ile Arg Thr Gln Phe Asp Asp Asn Pro Asp Ala 
        35                  40                  45              


Arg Leu Pro Asn Ser Gly Asp Leu Trp Ser Ile His Met Asp Phe Asp 
    50                  55                  60                  


Thr Lys Arg Leu Asp Pro Trp Glu Arg Ile Ile Pro Thr Phe Lys Tyr 
65                  70                  75                  80  


Asn Arg Asp Val Pro Phe Phe Glu Met Leu Val Pro Thr Thr Asp Thr 
                85                  90                  95      


Val Arg Tyr Gly Tyr Leu Met Glu Lys Leu Leu Ala Val Lys His Ser 
            100                 105                 110         


Val Leu Phe Thr Gly Ile Thr Gly Val Gly Lys Ser Val Ile Ala Lys 
        115                 120                 125             


Gly Leu Leu Asn Lys Ile Gln Glu Ser Ala Gly Tyr Val Pro Val Tyr 
    130                 135                 140                 


Leu Asn Phe Ser Ala Gln Thr Ser Ser Ala Arg Thr Gln Glu Ile Ile 
145                 150                 155                 160 


Glu Ser Lys Leu Glu Arg Lys Arg Lys Asn Ile Leu Gly Ala Pro Gly 
                165                 170                 175     


Asn Lys Arg Ile Val Ile Phe Val Asp Asp Leu Asn Met Pro Arg Leu 
            180                 185                 190         


Asp Arg Tyr Gly Ser Gln Pro Pro Ile Glu Leu Leu Arg Gln Tyr Gln 
        195                 200                 205             


Asp Phe Gly Gly Phe Tyr Asp Arg Asn Lys Leu Phe Trp Lys Glu Ile 
    210                 215                 220                 


Gln Asp Val Thr Ile Ile Ser Ala Cys Ala Pro Pro Gly Gly Gly Arg 
225                 230                 235                 240 


Asn Pro Val Thr Pro Arg Phe Ile Arg His Phe Ser Met Leu Cys Leu 
                245                 250                 255     


Pro Met Pro Ser Glu His Ser Leu Lys Gln Ile Phe Gln Ala Ile Leu 
            260                 265                 270         


Asn Gly Phe Leu Ser Asp Phe Pro Pro Ala Val Lys Gln Thr Ala Ser 
        275                 280                 285             


Ser Ile Val Glu Ala Ser Val Glu Ile Tyr Asn Lys Met Ser Val Asp 
    290                 295                 300                 


Leu Leu Pro Thr Pro Ala Lys Ser His Tyr Val Phe Asn Leu Arg Asp 
305                 310                 315                 320 


Leu Ser Lys Cys Val Gln Asp Lys His Phe Gly Ile Ala Ile Asp Leu 
                325                 330                 335     


Glu Tyr Phe Leu Asn Lys Pro Ile Ile Phe Gly Asp Phe Ile Lys Phe 
            340                 345                 350         


Gly Ala Asp Lys Ala Asp Arg Ile Tyr Asp Asp Met Pro Asp Ile Glu 
        355                 360                 365             


Lys Thr Ala Asn Val Leu Gln Asp Tyr Leu Asp Asp Tyr Asn Leu Thr 
    370                 375                 380                 


Asn Pro Lys Glu Val Lys Leu Val Phe Phe Gln Asp Ala Ile Glu His 
385                 390                 395                 400 


Val Ser Arg Ile Ala Arg Met Ile Arg Gln Glu Arg Gly Asn Ala Leu 
                405                 410                 415     


Leu Val Gly Val Gly Gly Thr Gly Lys Gln Ser Leu Thr Arg Leu Ala 
            420                 425                 430         


Ala His Ile Cys Gly Tyr Lys Cys Leu Gln Ile Glu Leu Ser Arg Gly 
        435                 440                 445             


Tyr Asn Tyr Asp Ser Phe His Glu Asp Leu Arg Lys Leu Tyr Lys Met 
    450                 455                 460                 


Ala Gly Val Glu Asp Lys Asn Met Val Phe Leu Phe Thr Asp Thr Gln 
465                 470                 475                 480 


Ile Val Val Glu Glu Phe Leu Glu Asp Ile Asn Asn Ile Leu Asn Ser 
                485                 490                 495     


Gly Glu Val Pro Asn Leu Phe Glu Lys Asp Glu Leu Glu Gln Val Leu 
            500                 505                 510         


Ala Ala Thr Arg Pro Arg Ala Lys Glu Val Gly Ile Ser Glu Gly Asn 
        515                 520                 525             


Arg Asp Glu Val Gly Cys Ala Arg Val Val Met Trp Leu Tyr His Lys 
    530                 535                 540                 


Asn Val Ser Ser Pro Phe Ile 
545                 550     


<210>  1113
<211>  2901
<212>  DNA
<213>  Homosapiens

<400>  1113
atgaaagggg aaagagaaag gaccagggaa ggttcagaag caattcaggg ctctggcaat     60

gggcagccag aggacagcgc tggaacttca ctttacccct cttgcggtca cacgaggtgg    120

gcggcggccc cggcagggtt tgggcgggag aaacgcggtt cgggactccg ctgccgccta    180

ggcgcggggc tgacctgcgg gggtggggtg gggggaggga ggaggatgag tccctggagc    240

tggttcctgc tgcagaccct ctgcctcctg cccacgggcg cagcttcgcg gcgcggggcg    300

cccggcaccg ccaactgcga gctcaagccc caaccgactt ccgcggctgg gctttcacct    360

agcaccgcgg cgctccttgc tcgctctcct ctccgtgccc tcgggttccc ctttcccgcg    420

ggggcgcagc ccgcaggctc caagcgactc agtgccctgg cctttgccct ccgccagccc    480

aagggcgtcc gagagagcct ctggggtctc gccagccatt ttcgcgagct ttcgggggac    540

ggatccgcca gggacaaagc agaggacggc caaatagagc cgatcctgga gctccgggct    600

gggaagacgc acggtgttcg cctctgtaag gcgtcgcggg gctgcggacg gccctctacc    660

aaggcaggag gcgcggcagc tggagagggg agtctgcacc aggcatggtt tcaaactctg    720

ttgcggtgtg gccgcttcat gcttgttaga caaggcagga gtccatctcc tcacaagaaa    780

gcacattgcc tttcacttct gcaaaaccta ttaccgactg gtaattatga cgactgggca    840

ttccactgca ccattgttga tgtcatgagt gtggcagcca tcaagattca gcccacagac    900

tgggaagtcc ccaggatctc tttaatggtt ccagaaagtt ctctggctaa agattggctt    960

cgagggcaga agcagaagca aagcgagctg aattccttct tgtggaccat taagcgagac   1020

ccaccatctt acttctttgg cacaatccat gtcccgtaca cccgagtttg ggacttcatc   1080

cccgacaact ctaaggaggc tttcctgcag agcagcattg tgtactttga gttggatctc   1140

acagacccct ataccatctc agctctcacc agctgtcaga tgctgccaca gggcgagaac   1200

ctccaagatg tgctccccag ggacatctac tgccgcctca agcgccacct ggagtatgtc   1260

aagctcatga tgcccttgtg gatgacccca gaccagcgcg gcaaggggct ctacgcagac   1320

tacctcttca atgctattgc cggaaactgg gagcgcaaga ggcctgtctg ggtgatgctc   1380

atggtcaact ccctgactga agtggacatt aagtcccgtg gagtgcctgt cttagacctg   1440

ttccttgccc aggaggctga gcggctgagg aaacagactg gggcagtgga aaaggtggaa   1500

gagcagtgcc atccattgaa tgggttgaac ttttcacagg gagctgtcac tctgcacaat   1560

ggagataaag gtctcatcac tgggcctttg gctgctccta cattgggcat atgggtcatc   1620

tttgcagttg tcacattcct gctgccctct ggggaaagcc tggtggctct tgctgaggtg   1680

ctggaagcac ctccagactt ggttgctgct acactaagag agcctgctgc agtgcctgtg   1740

tctacctgtg ctgccacccc tgttgtcctt tgccaggctt cacaggttta tgactgtaga   1800

agaaaaacac tacgactggc ggaagcatgc tggcccattc tgccaacacc tcaacagccc   1860

acatcccttc tggcgagaga acaacagtcc ttgtacccca ggtgtgttca gctgattcat   1920

gtgagaggga tgggaaggat gggaacacag tatggtctag agggtaccaa gacagaagag   1980

gctattgtgc agaaccttgg ggagacgcct tccagagaga ctggaggtgc ctctgccaga   2040

gaaaaggagg aggtcatctt tgctttgaac cagaccctcc tgcagcagga aagcctgcga   2100

gcaggcagtc ttcagatccc ctacacgacg gaggatctca tcaaacacta taactgcggg   2160

gacctcagct ccgtcatcct cagccatgac agctcccagg ttcccaattt tattaatgcc   2220

acgctaccac ctcaggagcg catcactgct caggagattg acagctactt acgccgggag   2280

ctgatctaca agcggaatga gagaataggg aagcgggtga aggccctttt ggaggagttc   2340

cctgacaaag gcttcttctt tgcctttgga gctggtcatt tcatgggcaa caacacagtg   2400

ctggatgttt tgcggcgtga aggctatgag gtagaacacg cccctgctgg acgacccatc   2460

cacaaaggga agagtaaaaa gacctccaca cggcccactc tgtccaccat ctttgctcca   2520

aaagtcccta ccctggaagt accggcacca gaagccgtat cctcagggca ctcaacgctg   2580

cctccccttg tgtcccggcc tggaagtgcc gacacgccca gtgaggccga acagaggttc   2640

cggaagaagc ggaggcggtc acagcggagg ccgcgactcc ggcaattcag cgatctgtgg   2700

gtccgcctgg aggagagtga catagtcccg caactccagg tccctgtcct ggacaggcac   2760

atctccactg aactgcggct ccctcgccgt gggcattccc accacagcca gatggtggcc   2820

agcagtgcct gcctgtctct ctggactcct gtgttctggg tgctggtgct ggctttccaa   2880

acagagacac ccctcctgta a                                             2901


<210>  1114
<211>  966
<212>  PRT
<213>  Homosapiens

<400>  1114

Met Lys Gly Glu Arg Glu Arg Thr Arg Glu Gly Ser Glu Ala Ile Gln 
1               5                   10                  15      


Gly Ser Gly Asn Gly Gln Pro Glu Asp Ser Ala Gly Thr Ser Leu Tyr 
            20                  25                  30          


Pro Ser Cys Gly His Thr Arg Trp Ala Ala Ala Pro Ala Gly Phe Gly 
        35                  40                  45              


Arg Glu Lys Arg Gly Ser Gly Leu Arg Cys Arg Leu Gly Ala Gly Leu 
    50                  55                  60                  


Thr Cys Gly Gly Gly Val Gly Gly Gly Arg Arg Met Ser Pro Trp Ser 
65                  70                  75                  80  


Trp Phe Leu Leu Gln Thr Leu Cys Leu Leu Pro Thr Gly Ala Ala Ser 
                85                  90                  95      


Arg Arg Gly Ala Pro Gly Thr Ala Asn Cys Glu Leu Lys Pro Gln Pro 
            100                 105                 110         


Thr Ser Ala Ala Gly Leu Ser Pro Ser Thr Ala Ala Leu Leu Ala Arg 
        115                 120                 125             


Ser Pro Leu Arg Ala Leu Gly Phe Pro Phe Pro Ala Gly Ala Gln Pro 
    130                 135                 140                 


Ala Gly Ser Lys Arg Leu Ser Ala Leu Ala Phe Ala Leu Arg Gln Pro 
145                 150                 155                 160 


Lys Gly Val Arg Glu Ser Leu Trp Gly Leu Ala Ser His Phe Arg Glu 
                165                 170                 175     


Leu Ser Gly Asp Gly Ser Ala Arg Asp Lys Ala Glu Asp Gly Gln Ile 
            180                 185                 190         


Glu Pro Ile Leu Glu Leu Arg Ala Gly Lys Thr His Gly Val Arg Leu 
        195                 200                 205             


Cys Lys Ala Ser Arg Gly Cys Gly Arg Pro Ser Thr Lys Ala Gly Gly 
    210                 215                 220                 


Ala Ala Ala Gly Glu Gly Ser Leu His Gln Ala Trp Phe Gln Thr Leu 
225                 230                 235                 240 


Leu Arg Cys Gly Arg Phe Met Leu Val Arg Gln Gly Arg Ser Pro Ser 
                245                 250                 255     


Pro His Lys Lys Ala His Cys Leu Ser Leu Leu Gln Asn Leu Leu Pro 
            260                 265                 270         


Thr Gly Asn Tyr Asp Asp Trp Ala Phe His Cys Thr Ile Val Asp Val 
        275                 280                 285             


Met Ser Val Ala Ala Ile Lys Ile Gln Pro Thr Asp Trp Glu Val Pro 
    290                 295                 300                 


Arg Ile Ser Leu Met Val Pro Glu Ser Ser Leu Ala Lys Asp Trp Leu 
305                 310                 315                 320 


Arg Gly Gln Lys Gln Lys Gln Ser Glu Leu Asn Ser Phe Leu Trp Thr 
                325                 330                 335     


Ile Lys Arg Asp Pro Pro Ser Tyr Phe Phe Gly Thr Ile His Val Pro 
            340                 345                 350         


Tyr Thr Arg Val Trp Asp Phe Ile Pro Asp Asn Ser Lys Glu Ala Phe 
        355                 360                 365             


Leu Gln Ser Ser Ile Val Tyr Phe Glu Leu Asp Leu Thr Asp Pro Tyr 
    370                 375                 380                 


Thr Ile Ser Ala Leu Thr Ser Cys Gln Met Leu Pro Gln Gly Glu Asn 
385                 390                 395                 400 


Leu Gln Asp Val Leu Pro Arg Asp Ile Tyr Cys Arg Leu Lys Arg His 
                405                 410                 415     


Leu Glu Tyr Val Lys Leu Met Met Pro Leu Trp Met Thr Pro Asp Gln 
            420                 425                 430         


Arg Gly Lys Gly Leu Tyr Ala Asp Tyr Leu Phe Asn Ala Ile Ala Gly 
        435                 440                 445             


Asn Trp Glu Arg Lys Arg Pro Val Trp Val Met Leu Met Val Asn Ser 
    450                 455                 460                 


Leu Thr Glu Val Asp Ile Lys Ser Arg Gly Val Pro Val Leu Asp Leu 
465                 470                 475                 480 


Phe Leu Ala Gln Glu Ala Glu Arg Leu Arg Lys Gln Thr Gly Ala Val 
                485                 490                 495     


Glu Lys Val Glu Glu Gln Cys His Pro Leu Asn Gly Leu Asn Phe Ser 
            500                 505                 510         


Gln Gly Ala Val Thr Leu His Asn Gly Asp Lys Gly Leu Ile Thr Gly 
        515                 520                 525             


Pro Leu Ala Ala Pro Thr Leu Gly Ile Trp Val Ile Phe Ala Val Val 
    530                 535                 540                 


Thr Phe Leu Leu Pro Ser Gly Glu Ser Leu Val Ala Leu Ala Glu Val 
545                 550                 555                 560 


Leu Glu Ala Pro Pro Asp Leu Val Ala Ala Thr Leu Arg Glu Pro Ala 
                565                 570                 575     


Ala Val Pro Val Ser Thr Cys Ala Ala Thr Pro Val Val Leu Cys Gln 
            580                 585                 590         


Ala Ser Gln Val Tyr Asp Cys Arg Arg Lys Thr Leu Arg Leu Ala Glu 
        595                 600                 605             


Ala Cys Trp Pro Ile Leu Pro Thr Pro Gln Gln Pro Thr Ser Leu Leu 
    610                 615                 620                 


Ala Arg Glu Gln Gln Ser Leu Tyr Pro Arg Cys Val Gln Leu Ile His 
625                 630                 635                 640 


Val Arg Gly Met Gly Arg Met Gly Thr Gln Tyr Gly Leu Glu Gly Thr 
                645                 650                 655     


Lys Thr Glu Glu Ala Ile Val Gln Asn Leu Gly Glu Thr Pro Ser Arg 
            660                 665                 670         


Glu Thr Gly Gly Ala Ser Ala Arg Glu Lys Glu Glu Val Ile Phe Ala 
        675                 680                 685             


Leu Asn Gln Thr Leu Leu Gln Gln Glu Ser Leu Arg Ala Gly Ser Leu 
    690                 695                 700                 


Gln Ile Pro Tyr Thr Thr Glu Asp Leu Ile Lys His Tyr Asn Cys Gly 
705                 710                 715                 720 


Asp Leu Ser Ser Val Ile Leu Ser His Asp Ser Ser Gln Val Pro Asn 
                725                 730                 735     


Phe Ile Asn Ala Thr Leu Pro Pro Gln Glu Arg Ile Thr Ala Gln Glu 
            740                 745                 750         


Ile Asp Ser Tyr Leu Arg Arg Glu Leu Ile Tyr Lys Arg Asn Glu Arg 
        755                 760                 765             


Ile Gly Lys Arg Val Lys Ala Leu Leu Glu Glu Phe Pro Asp Lys Gly 
    770                 775                 780                 


Phe Phe Phe Ala Phe Gly Ala Gly His Phe Met Gly Asn Asn Thr Val 
785                 790                 795                 800 


Leu Asp Val Leu Arg Arg Glu Gly Tyr Glu Val Glu His Ala Pro Ala 
                805                 810                 815     


Gly Arg Pro Ile His Lys Gly Lys Ser Lys Lys Thr Ser Thr Arg Pro 
            820                 825                 830         


Thr Leu Ser Thr Ile Phe Ala Pro Lys Val Pro Thr Leu Glu Val Pro 
        835                 840                 845             


Ala Pro Glu Ala Val Ser Ser Gly His Ser Thr Leu Pro Pro Leu Val 
    850                 855                 860                 


Ser Arg Pro Gly Ser Ala Asp Thr Pro Ser Glu Ala Glu Gln Arg Phe 
865                 870                 875                 880 


Arg Lys Lys Arg Arg Arg Ser Gln Arg Arg Pro Arg Leu Arg Gln Phe 
                885                 890                 895     


Ser Asp Leu Trp Val Arg Leu Glu Glu Ser Asp Ile Val Pro Gln Leu 
            900                 905                 910         


Gln Val Pro Val Leu Asp Arg His Ile Ser Thr Glu Leu Arg Leu Pro 
        915                 920                 925             


Arg Arg Gly His Ser His His Ser Gln Met Val Ala Ser Ser Ala Cys 
    930                 935                 940                 


Leu Ser Leu Trp Thr Pro Val Phe Trp Val Leu Val Leu Ala Phe Gln 
945                 950                 955                 960 


Thr Glu Thr Pro Leu Leu 
                965     


<210>  1115
<211>  482
<212>  DNA
<213>  Homosapiens

<400>  1115
gcgggcgccg ctcttttgtt tcttgctgca gcaacgcgag tgggagcacc aggatctcgg     60

gctcggaacg agactgcacg gattgtttta agaaaatggc agacaaacca gacatggggg    120

aaatcgccag cttcgataag gccaagctga agaaaacgga gacgcaggag aagaacaccc    180

tgccgaccaa agagaccatt gagcaggaga agcggagtga aatttcctaa gatcctggag    240

gatttcctac ccccgtcctc ttcgagaccc cagtcgtgat gtggaggaag agccacctgc    300

aagatggaca cgagccacaa gctgcactgt gaacctgggc actccgcgcc gatgccaccg    360

gcctgtgggt ctctgaaggg accccccccc aatcggactg ccaaattctc cggtttgccc    420

cgggatatta tagaaaatta tttgtatgaa taatgaaaat aaaacacacc tcgtggcatg    480

gc                                                                   482


<210>  1116
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  1116

Met Ala Asp Lys Pro Asp Met Gly Glu Ile Ala Ser Phe Asp Lys Ala 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Thr Leu Pro Thr Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Arg Ser Glu Ile Ser 
        35                  40                  


<210>  1117
<211>  937
<212>  DNA
<213>  Homosapiens

<400>  1117
cttcttctcc gagaaaacac caaatggcgg atgacgccgg tgcagcgggg gggcccagag     60

ccctggtggc catgggatag ggaaccgcgg tggcttccac ggaggtttcg gcagtggcat    120

ccggggccgg ggtcgcggga gtggacgggg ccgtgccgag gccgcggagc tcgcggaggc    180

aaggccgagg ataaggagtg gatgcctgtc accaagctgg gccgcttggt caaggacatg    240

aagatcaagt ccctggagga gatctatctc ttctccctgc ccattaagga atctgagatc    300

attgatttct tcctggggga ctctctcaag gatgaggttt tgaagattat gccggtgcag    360

aagcagaccc gtgccggcca gcgcaccagg ttcaaggcgt ttgttgctat cggagactac    420

aatggccatg tcggtctggg tgttaagtgc tccaaggagg tggccacagc catccgtggg    480

gccatcatcc tggccaagct ctccattgtc cccgtgcgca gaggctactg ggggaacaag    540

atcggcaagc cccacaccgt cccttgcaag gtgacaggcc gctgcggctc tgtgctggtg    600

cgcctcatcc ctgcacccag gggcactggc atcgtctccg cacctgtgcc caagaagctg    660

ctcatgatgg ctggtatcga tgactgctac acctcagccc ggggctgcac tgccaccctg    720

ggcaacttcg ccaaggccac ctttgatgcc atctctaaga cctacagcta cctgaccccc    780

gacctctgga aggagactgt atttaccaag tctccctatc aggaattcac tgaccacctc    840

gtcaagaccc acaccagagt ctcggtgcag cggacccagg cttcagatgt ggctacaaca    900

tagggttttt atacaagaaa aataaagtga attaagc                             937


<210>  1118
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  1118

Met Thr Pro Val Gln Arg Gly Gly Pro Glu Pro Trp Trp Pro Trp Asp 
1               5                   10                  15      


Arg Glu Pro Arg Trp Leu Pro Arg Arg Phe Arg Gln Trp His Pro Gly 
            20                  25                  30          


Pro Gly Ser Arg Glu Trp Thr Gly Pro Cys Arg Gly Arg Gly Ala Arg 
        35                  40                  45              


Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr Lys Leu Gly 
    50                  55                  60                  


Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu Ile Tyr Leu 
65                  70                  75                  80  


Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe Phe Leu Gly 
                85                  90                  95      


Asp Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val Gln Lys Gln 
            100                 105                 110         


Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val Ala Ile Gly 
        115                 120                 125             


Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser Lys Glu Val 
    130                 135                 140                 


Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu Ser Ile Val 
145                 150                 155                 160 


Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys Pro His Thr 
                165                 170                 175     


Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu Val Arg Leu 
            180                 185                 190         


Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro Val Pro Lys 
        195                 200                 205             


Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr Ser Ala Arg 
    210                 215                 220                 


Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr Phe Asp Ala 
225                 230                 235                 240 


Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp Lys Glu Thr 
                245                 250                 255     


Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His Leu Val Lys 
            260                 265                 270         


Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Ser Asp Val Ala 
        275                 280                 285             


Thr Thr 
    290 


<210>  1119
<211>  2390
<212>  DNA
<213>  Homosapiens

<400>  1119
ggatttgcgg agcgccgcgc cgctgccggg agccggcagg cccgagagtg accggagtca     60

cggcgggcgc cggcggagct gcggcgtcgg acccgcctcc tggaggagct cagccccgac    120

caggcccggc cccattcccg ccccgcgccg cctccccgcc gccgccgccg ccgccgccgc    180

gggagcgctc ccctgcccac cccgcccccg cggccgagcc cgggagtcga gtgggagtcg    240

gccggccggc gcgggcagcg ccgggacccc gcgggggaca ctgcagccgg agcccgggag    300

gggccgcgcc gccaccgtct gaactaggat gtcccgacat gaaggtgtca gctgtgatgc    360

atgtttaaaa ggaaattttc gaggtcgcag atataagtgt ttaatttgct acgattacga    420

tctttgtgca tcttgttatg aaagtggtgc aacaacaaca aggcatacaa ctgaccaccc    480

aatgcagtgc atattaacaa gggtagattt tgatttatac tatggtgggg aagctttctc    540

tgtagagcag ccacagtctt ttacttgtcc ctattgtgga aaaatgggct atacggagac    600

atctcttcaa gaacatgtta cttctgaaca tgcagaaaca tcaacagaag tgatttgtcc    660

aatatgtgca gcgttacctg gaggcgatcc taatcatgtc acggatgact ttgcagctca    720

tcttacactt gaacacagag cccctagaga tttagatgaa tcgagtggtg ttcgacatgt    780

acgtagaatg tttcaccctg gccggggatt aggaggtcct cgtgctcgta gatcaaacat    840

gcactttact agcagttcta ctggtggact ttcttcttct cagagttcat attctccaag    900

caatagggaa gccatggatc ctatagctga gcttttatct cagttatcag gagtgagacg    960

ttctgcagga ggacagctta attcctctgg cccttccgct tctcagttac aacaactgca   1020

gatgcagctg cagctagaac ggcagcatgc ccaggcagca cggcaacaac tggagaccgc   1080

acgcaacgca acccggcgta ctaacacaag cagtgtcacc actacaatca cacaatccac   1140

agcaacaacc aacatagcta atacagaaag cagtcagcag actctacaga attcccagtt   1200

tcttttaaca aggttgaatg atcctaaaat gtctgaaacg gagcgccagt ccatggaaag   1260

cgagcgtgca gaccgcagcc tgtttgtcca agagctcctt ctgtccactt tagtgcgtga   1320

agagagctca tcctcagatg aggatgatcg gggggagatg gcagattttg gtgctatggg   1380

ctgtgtagat attatgcctt tagatgttgc tttagaaaac ctaaatttaa aagagagtaa   1440

taaaggaaat gagcctccac cacctcctct ttgatgacat cccaattcgc agacaatgtc   1500

ctctgtgctg tatttgccaa tgaaagtgga caacaactat cttgggtttg tttggtgatt   1560

gtaatttcag gtctgtcact cttgttacat tgtgtacatt caaaaggaag agagaaaata   1620

tatatgataa tcatttccac ttaactaatt tttacttcta gcaggtaaat gtaggtagca   1680

gtgcaggggt gatctctgct tcctgtacct tgacatgcaa aaggctctcc taatactcca   1740

cattcaaact gaagaggaaa attgaaatct ctaatgaagc tgctgtgtgt atttatgaat   1800

attaatgaat aaaaactgct tggatggttt accttaacta ctgcatgagg ttttttgcag   1860

cgtgcatgag ttttagtgac cttgttattt aagaagttaa atacaaggag taaaacttaa   1920

aaaaaaaata caaagcccaa agctttccca aacattattc aatggttaca cgacgaagta   1980

gcttttgaat aatgtctgcc tgaatcacct ttctttgtgt gcctcctacg cacaaagcca   2040

gctctgcagt ggaatctggg gattatagcc gggtgtggca ctccgccctg tgtgactgtc   2100

ctgtcgccct gttagtcatc ttgcctgtgt ggagctcagc ctgtctcttt aactcatctg   2160

tagaagacac accagtaaag ctactgttgg aatctgctgc aggggccttt gtgtgcccta   2220

aaaacaaatc ctgttcatgt ttgtttaaag tttttacttt ttgtggttgt ttaaaatttt   2280

ttcaattgtt aaatatgttt tattcaggtg tagatgaatt tcatttattg actgttcaac   2340

agagttaacc tgaattatgt tgtctttgtt tttaaaaatc tcacattctc              2390


<210>  1120
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  1120

Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys Gly Asn 
1               5                   10                  15      


Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr Asp Leu 
            20                  25                  30          


Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His Thr Thr 
        35                  40                  45              


Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp Leu Tyr 
    50                  55                  60                  


Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe Thr Cys 
65                  70                  75                  80  


Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln Glu His 
                85                  90                  95      


Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys Pro Ile 
            100                 105                 110         


Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp Asp Phe 
        115                 120                 125             


Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu Asp Glu 
    130                 135                 140                 


Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly Arg Gly 
145                 150                 155                 160 


Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr Ser Ser 
                165                 170                 175     


Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro Ser Asn 
            180                 185                 190         


Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu Ser Gly 
        195                 200                 205             


Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro Ser Ala 
    210                 215                 220                 


Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg Gln His 
225                 230                 235                 240 


Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala Thr Arg 
                245                 250                 255     


Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser Thr Ala 
            260                 265                 270         


Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu Gln Asn 
        275                 280                 285             


Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser Glu Thr 
    290                 295                 300                 


Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu Phe Val 
305                 310                 315                 320 


Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser Ser Ser 
                325                 330                 335     


Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met Gly Cys 
            340                 345                 350         


Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn Leu Lys 
        355                 360                 365             


Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu 
    370                 375                 380     


<210>  1121
<211>  3267
<212>  DNA
<213>  Homosapiens

<400>  1121
ggtcaccgcc cggctgcggg gccagtggca ggagcgccac gcaccgccag ccgcaggggg     60

cgtgggatgg gggcggccgg ggaggggggc gcccacactg actagagcca accgcgcact    120

tcaaaagggt gtcggtgccg cgctcccctc ccgcggcccg ggaacttcaa agcgggccgt    180

gctgccccgg ctgcctcgct ctgctctggg gcctcgcagc cccggcgcgg ccgcctggtg    240

gcgatgaccc gggcgctctg ctcagcgctc cgccaggctc tcctgctgct cgcagcggcc    300

gccgagctct cgccaggact gaagtgtgta tgtcttttgt gtgattcttc aaactttacc    360

tgccaaacag aaggagcatg ttgggcatca gtcatgctaa ccaatggaaa agagcaggtg    420

atcaaatcct gtgtctccct tccagaactg aatgctcaag tcttctgtca tagttccaac    480

aatgttacca aaaccgaatg ctgcttcaca gatttttgca acaacataac actgcacctt    540

ccaacagcat caccaaatgc cccaaaactt ggacccatgg agctggccat cattattact    600

gtgcctgttt gcctcctgtc catagctgcg atgctgacag tatgggcatg ccagggtcga    660

cagtgctcct acaggaagaa aaagagacca aatgtggagg aaccactctc tgagtgcaat    720

ctggtaaatg ctggaaaaac tctgaaagat ctgatttatg atgtgaccgc ctctggatct    780

ggctctggtc tacctctgtt ggttcaaagg acaattgcaa ggacgattgt gcttcaggaa    840

atagtaggaa aaggtagatt tggtgaggtg tggcatggaa gatggtgtgg ggaagatgtg    900

gctgtgaaaa tattctcctc cagagatgaa agatattggt ttcgtgaggc agaaatttac    960

cagacggtca tgctgcgaca tgaaaacatc cttggtttca ttgctgctga caacaaagat   1020

aatggaactt ggactcaact ttggctggta tctgaatatc atgaacaggg ctccttatat   1080

gactatttga atagaaatat agtgaccatg gctggaatga tcaagctggc gctctcaatt   1140

gctagtggtc tggcacacct tcatatggag attgttggta cacaaggtaa acctgctatt   1200

gctcatcgag acataaaatc aaagaatatc ttagtaaaaa agtgtgaaac ttgtgccata   1260

gcggacttag ggttggctgt gaagcatgat tcaatactga acactatcga catacctcag   1320

aatcctaaag tgggaaccaa gaggtatatg gctcctgaaa tgcttgatga tacaatgaat   1380

gtgaatatct ttgagtcctt caaacgagct gacatctatt ctgttggtct ggtttactgg   1440

gaaatagccc ggaggtgttc agtcggagga attgttgagg agtaccaatt gccttattat   1500

gacatggtgc cttcagatcc ctcgatagag gaaatgagaa aggttgtttg tgaccagaag   1560

tttcgaccaa gtatcccaaa ccagtggcaa agttgtgaag cactccgagt catggggaga   1620

ataatgcgtg agtgttggta tgccaacgga gcggcccgcc taactgctct tcgtattaag   1680

aagactatat ctcaactttg tgtcaaagaa gactgcaaag cctaatgatg ataattatgt   1740

taaaaagaaa tctctcatag ctttcttttc cattttcccc tttatgtgaa tgtttttgcc   1800

attttttttt tgttctacct caaagataag acagtacagt atttaagtgc ccataaggca   1860

gcatgaaaag ataactctaa agttaagcat gggcaggagt tgacttcatc caatctctat   1920

gttatgttta attttatttt gaaagcaaca cctcaactca tctttttatt taataaggaa   1980

gaaatatatt acaaaagtat aaaataagct ctataaaaat gttatagtca ttaagttttt   2040

attttacttg aaccaagagc acatgaatga acaggaaaag atgtaaaaac atttttttct   2100

gagatgaaaa catattaatt aaacatgcaa attagagcat gctatcttta ggtgatgcaa   2160

tctatgtttc ccccttttta agttagcagg actttttaaa aataaatatt gctctaaact   2220

ttaatatatc gaacgtgaga gtggagctgc ttagtggaag atgtaagtga ggtgggtgtc   2280

ccatgtgctt ggtctcccct tctgctgttc tcctgttctt cataatccac tactgcagca   2340

gtccctgaac cactaaactt gttcctttca tttacaaaag agatacctga catcctgaga   2400

cactgagaaa tgtcctgaag tcacacagct aatggcagaa ctggcactag gtccaaatct   2460

tgtgataatg aacaccgtaa ggttagctag cttcctactt tcccttgaat agtgcttttc   2520

tccctatgta atatctttta ttatgatatt tgtggtttag aaggcatatt gagttatttt   2580

gcagaatcat aatggacccg cacaaaatct cagaaccata tctgttgaca ttttttctca   2640

tagaaatatc atggttaccc catttgttaa tgagcattaa tgttttctga acacttccaa   2700

agattaatca aacataaata ttcattgtct gaaaatgtct ttaagataca attcagaggt   2760

ccctatttcc tttgtacata cacacttaga aagaaaagac agaaaaggaa gaggaaggaa   2820

ggaaatattt tgagaatata ttgagaagaa ttaagaaaac tcttcaatga agtgttaaca   2880

accaaaccct acagacggta tcagaaacag caaatagata ttcctctacc ctttcacagt   2940

gagtgagtga gtacagaaga atgctcatga tagttttgcc ttcattctac tttctgtgga   3000

cacagagtaa tgaatattta atgggacatt aaatatgccc ttcaaatcta taattttact   3060

ttggtaaacg agatttaaca tgatgtcttt tatgctccta aaacatcttt tttcaaactc   3120

cattccttag aacattcttc tactgagatg atccaagacc aaaagtgttc tttggtactt   3180

gcttataaag tgatagtaca tgttagcata taatgtattt tgaagagtga agtaaatgct   3240

attgataaca gaaaaaaaaa aaaaaaa                                       3267


<210>  1122
<211>  493
<212>  PRT
<213>  Homosapiens

<400>  1122

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met 
            100                 105                 110         


Glu Leu Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala 
        115                 120                 125             


Ala Met Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg 
    130                 135                 140                 


Lys Lys Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu 
145                 150                 155                 160 


Val Asn Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            180                 185                 190         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        195                 200                 205             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    210                 215                 220                 


Ser Ser Arg Asp Glu Arg Tyr Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
225                 230                 235                 240 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                245                 250                 255     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            260                 265                 270         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        275                 280                 285             


Met Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    290                 295                 300                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
305                 310                 315                 320 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                325                 330                 335     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            340                 345                 350         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        355                 360                 365             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    370                 375                 380                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
385                 390                 395                 400 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                405                 410                 415     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            420                 425                 430         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        435                 440                 445             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    450                 455                 460                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
465                 470                 475                 480 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                485                 490             


<210>  1123
<211>  2952
<212>  DNA
<213>  Homosapiens

<400>  1123
gaagcgaata gcgttttcag agatattggg cggctcaagg gtcttactct gtcgcccagt     60

ctgtaatgca gtgctgtgac catagcccac tgcagcctcc acctcccagg ctcaagcagt    120

ccttcccccc tcgccctcat gaatagctgg gactacagcc tggagcattg gtaagcgtca    180

cactgccaaa gtgagagctg ctggagaact cataatccca ggaacgcctc ttctactctc    240

cgagtacccc agtgaccaga gtgagagaag ctctgaacga gggcacgcgg cttgaaggac    300

tgtgggcaga tgtgaccaag agcctgcatt aagttgtaca atggtagatg gagtgatgat    360

tcttcctgtg cttatcatga ttgctctccc ctcccctagt atggaagatg agaagcccaa    420

ggtcaacccc aaactctaca tgtgtgtgtg tgaaggtctc tcctgcggta atgaggacca    480

ctgtgaaggc cagcagtgct tttcctcact gagcatcaac gatggcttcc acgtctacca    540

gaaaggctgc ttccaggttt atgagcaggg aaagatgacc tgtaagaccc cgccgtcccc    600

tggccaagct gtggagtgct gccaagggga ctggtgtaac aggaacatca cggcccagct    660

gcccactaaa ggaaaatcct tccctggaac acagaatttc cacttggagg ttggcctcat    720

tattctctct gtagtgttcg cagtatgtct tttagcctgc ctgctgggag ttgctctccg    780

aaaatttaaa aggcgcaacc aagaacgcct caatccccga gacgtggagt atggcactat    840

cgaagggctc atcaccacca atgttggaga cagcacttta gcagatttat tggatcattc    900

gtgtacatca ggaagtggct ctggtcttcc ttttctggta caaagaacag tggctcgcca    960

gattacactg ttggagtgtg tcgggaaagg caggtatggt gaggtgtgga ggggcagctg   1020

gcaaggggaa aatgttgccg tgaagatctt ctcctcccgt gatgagaagt catggttcag   1080

ggaaacggaa ttgtacaaca ctgtgatgct gaggcatgaa aatatcttag gtttcattgc   1140

ttcagacatg acatcaagac actccagtac ccagctgtgg ttaattacac attatcatga   1200

aatgggatcg ttgtacgact atcttcagct tactactctg gatacagtta gctgccttcg   1260

aatagtgctg tccatagcta gtggtcttgc acatttgcac atagagatat ttgggaccca   1320

agggaaacca gccattgccc atcgagattt aaagagcaaa aatattctgg ttaagaagaa   1380

tggacagtgt tgcatagcag atttgggcct ggcagtcatg cattcccaga gcaccaatca   1440

gcttgatgtg gggaacaatc cccgtgtggg caccaagcgc tacatggccc ccgaagttct   1500

agatgaaacc atccaggtgg attgtttcga ttcttataaa agggtcgata tttgggcctt   1560

tggacttgtt ttgtgggaag tggccaggcg gatggtgagc aatggtatag tggaggatta   1620

caagccaccg ttctacgatg tggttcccaa tgacccaagt tttgaagata tgaggaaggt   1680

agtctgtgtg gatcaacaaa ggccaaacat acccaacaga tggttctcag acccgacatt   1740

aacctctctg gccaagctaa tgaaagaatg ctggtatcaa aatccatccg caagactcac   1800

agcactgcgt atcaaaaaga ctttgaccaa aattgataat tccctcgaca aattgaaaac   1860

tgactgttga cattttcata gtgtcaagaa ggaagatttg acgttgttgt cattgtccag   1920

ctgggaccta atgctggcct gactggttgt cagaatggaa tccatctgtc tccctcccca   1980

aatggctgct ttgacaaggc agacgtcgta cccagccatg tgttggggag acatcaaaac   2040

caccctaacc tcgctcgatg actgtgaact gggcatttca cgaactgttc acactgcaga   2100

gactaatgtt ggacagacac tgttgcaaag gtagggactg gaggaacaca gagaaatcct   2160

aaaagagatc tgggcattaa gtcagtggct ttgcatagct ttcacaagtc tcctagacac   2220

tccccacggg aaactcaagg aggtggtgaa tttttaatca gcaatattgc ctgtgcttct   2280

cttctttatt gcactaggaa ttctttgcat tccttacttg cactgttact cttaatttta   2340

aagacccaac ttgccaaaat gttggctgcg tactccactg gtctgtcttt ggataatagg   2400

aattcaattt ggcaaaacaa aatgtaatgt cagactttgc tgcattttac acatgtgctg   2460

atgtttacaa tgatgccgaa cattaggaat tgtttataca caactttgca aattatttat   2520

tacttgtgca cttagtagtt tttacaaaac tgctttgtgc atatgttaaa gcttattttt   2580

atgtggtctt atgattttat tacagaaatg tttttaacac tatactctaa aatggacatt   2640

ttcttttatt atcagttaaa atcacatttt aagtgcttca catttgtatg tgtgtagact   2700

gtaacttttt ttcagttcat atgcagaacg tatttagcca ttacccacgt gacaccaccg   2760

aatatattat cgatttagaa gcaaagattt cagtagaatt ttagtcctga acgctacggg   2820

gaaaatgcat tttcttcaga attatccatt acgtgcattt aaactctgcc agaaaaaaat   2880

aactattttg ttttaatcta ctttttgtat ttagtagtta tttgtataaa ttaaataaac   2940

tgttttcaag tc                                                       2952


<210>  1124
<211>  509
<212>  PRT
<213>  Homosapiens

<400>  1124

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  1125
<211>  645
<212>  DNA
<213>  Homosapiens

<400>  1125
atggcggcgg aggcagggcg cgcggccgca ctcccgcctt tcctcagcgc tgatccaaag     60

aggattcagg gacctgcagg accgctaggt gtaggaccgc taaggtcgtc tctgctcggc    120

gccggggctt gggccgagga aagacgctgg ggtcgcgccc ctgaaggccg cctgagcgcg    180

gtttacttca gccggtattc tgcactcagc gccgcctgcc cacggccttc tctttgtttt    240

accagcagca gctggctaat ggaggccgcc gtccagtgtg gaggccgctt cttagcgttg    300

gctcttggcg ttcctgtgtc cagcggagaa tgtcttcatc gccggcttgg ctctccttcc    360

gcgccaactc ctatcctggg gcatttggga aatgcttcct ctggaggagg ggtgccattc    420

ccaggggtag agcccggcct ggggactgac ctgctaggtc agtctgttgg cagaatactc    480

aggtcaacct atttccccca ccggtggcat cttggacagc tgtagtacct cggcgcactc    540

aacatacaga ccctttcctc tgcacaagga tgcctcccat tgtccttcca gtgccaacca    600

ccttcttccc tctccattgc cctgatgcct ggcaaccact aagct                    645


<210>  1126
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  1126

Met Ala Ala Glu Ala Gly Arg Ala Ala Ala Leu Pro Pro Phe Leu Ser 
1               5                   10                  15      


Ala Asp Pro Lys Arg Ile Gln Gly Pro Ala Gly Pro Leu Gly Val Gly 
            20                  25                  30          


Pro Leu Arg Ser Ser Leu Leu Gly Ala Gly Ala Trp Ala Glu Glu Arg 
        35                  40                  45              


Arg Trp Gly Arg Ala Pro Glu Gly Arg Leu Ser Ala Val Tyr Phe Ser 
    50                  55                  60                  


Arg Tyr Ser Ala Leu Ser Ala Ala Cys Pro Arg Pro Ser Leu Cys Phe 
65                  70                  75                  80  


Thr Ser Ser Ser Trp Leu Met Glu Ala Ala Val Gln Cys Gly Gly Arg 
                85                  90                  95      


Phe Leu Ala Leu Ala Leu Gly Val Pro Val Ser Ser Gly Glu Cys Leu 
            100                 105                 110         


His Arg Arg Leu Gly Ser Pro Ser Ala Pro Thr Pro Ile Leu Gly His 
        115                 120                 125             


Leu Gly Asn Ala Ser Ser Gly Gly Gly Val Pro Phe Pro Gly Val Glu 
    130                 135                 140                 


Pro Gly Leu Gly Thr Asp Leu Leu Gly Gln Ser Val Gly Arg Ile Leu 
145                 150                 155                 160 


Arg Ser Thr Tyr Phe Pro His Arg Trp His Leu Gly Gln Leu 
                165                 170                 


<210>  1127
<211>  5411
<212>  DNA
<213>  Homosapiens

<400>  1127
gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc     60

ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc    120

tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc    180

gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc    240

cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc    300

gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg    360

ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg    420

gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc    480

tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa    540

tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa    600

aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt    660

ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga    720

aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt    780

gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct    840

ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa    900

gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt    960

gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat   1020

ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc   1080

cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga   1140

cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg   1200

ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc   1260

aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt   1320

gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac   1380

ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc   1440

cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga   1500

cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc   1560

ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct   1620

aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt   1680

tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt   1740

ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag   1800

cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga   1860

aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct   1920

ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat   1980

cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt   2040

cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa   2100

ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc   2160

gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt   2220

cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact   2280

ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa   2340

cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga   2400

gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga   2460

ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc   2520

cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt   2580

cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat   2640

ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc   2700

aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc   2760

ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct   2820

ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt   2880

tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt   2940

gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct   3000

ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct   3060

cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt   3120

ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct   3180

ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa   3240

gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga   3300

cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct   3360

ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct   3420

tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc   3480

attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag   3540

ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct   3600

cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga   3660

aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag   3720

ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta   3780

agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc   3840

tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac   3900

aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc   3960

cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac   4020

caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt   4080

atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag   4140

aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa   4200

ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat   4260

gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact   4320

ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag   4380

ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa   4440

tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat   4500

attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc   4560

tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct   4620

ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca   4680

catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc   4740

aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca   4800

ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa   4860

aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag   4920

tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat   4980

ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc   5040

ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag   5100

aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa   5160

atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg   5220

cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca   5280

tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt   5340

atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca   5400

aaagaacata t                                                        5411


<210>  1128
<211>  1366
<212>  PRT
<213>  Homosapiens

<400>  1128

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  1129
<211>  3883
<212>  DNA
<213>  Homosapiens

<400>  1129
gaggccgccg agtcggccgc ggccgaggag gggcaggcgg aggtcggggg cgccgcggcc     60

gcggggtcag gttccccggc gggaggcgca ggtggcggcc tggggagctg gcggccgctc    120

ctcgcctggc tgcagcggcg gcagccccag tgctgcccct gtgcggcgcc cctttcccgc    180

tccgccgcgc actgttgtca tggaggaacc agatggcggc tctggcctac aacctgggca    240

agcgggagat caaccactac ttcagcgtga ggagcgccaa ggtgctggcg ctggtggccg    300

tgctgctgct cgcagcgtgc cacctcgcct cccgccgcta ccgaggcaat gattcgtgtg    360

aataccttct ctcaagtggc agatttcttg gagagaaagt ttggcaacct cacagttgta    420

tgatgcataa atacaaaatc agtgaagcaa agaactgcct tgtagataaa catattgcat    480

ttattggaga ttccagaatt cgtcaattgt tttattcttt tgtaaaaata attaatcccc    540

aattcaaaga agaaggaaat aagcatgaaa acattccttt tgaagacaag actgcatcag    600

ttaaagtgga ttttctgtgg catcctgaag ttaatggttc tatgaaacag tgtatcaaag    660

tgtggactga ggattccatt gcaaagccac atgtgattgt agcaggagct gccacatggt    720

ccatcaagat tcacaatggt agcagtgaag cgctttctca atataaaatg aacatcacct    780

ccatagcacc acttttagaa aaattggcaa agactagtga tgtttattgg gtcttacaag    840

atcctgttta tgaagatcta ttaagtgaaa ataggaagat gatcactaat gagaagatag    900

atgcttacaa tgaagctgca gtcagtattt tgaatagtag caccagaaat tctaaatcaa    960

atgttaagat gttcagtgtt tccaaattaa ttgctcaaga aaccatcatg gaatctttgg   1020

atggcttaca tcttcctgaa tcgagcagag aaactactgc aatgattctt atgaatgtgt   1080

attgcaataa gattttgaag cctgtagatg ggtcctgttg tcaacctcgg cctcctgtta   1140

ctctcataca gaagctagct gcttgttttt tcactttatc tattatcgga tatttaattt   1200

tttacataat tcatcgtaat gctcatcgga agaataagcc gtgtactgat ttggaaagtg   1260

gagaggaaaa gaaaaatatt atcaataccc ctgtgtcttc attagaaata cttttacaat   1320

ctttctgcaa acttggcctg attatggcat atttctatat gtgtgacagt gcaaatctgt   1380

tcatgaagga aaacaaattt tatacacatt catctttctt tattccaatt atctacattt   1440

tggttttggg agtattttat aatgaaaata ctaaagagac taaagtatta aatagagaac   1500

aaacagacga atggaaaggc tggatgcaac ttgtgatttt gatttatcac atttctggag   1560

caagtacatt tttgcctgta tacatgcaca ttcgagttct ggttgctgca tatttatttc   1620

agacagggta tgggcatttc tcatactttt ggataaaagg agattttgga atctacagag   1680

tatgtcaggt tttatttcgt ctcaatttcc tggtagtggt gttatgtata gtaatggatc   1740

gaccttatca attctattac tttgtcccct tggtcactgt atggttcatg gtcatatatg   1800

ttactttagc actatggcca caaataatcc aaaaaaaagc aaacggaaat tgtttctggc   1860

attttggctt actgttgaaa ctaggctttt tgctgttatt catatgtttt ttggcatatt   1920

ctcagggtgc atttgagaag atcttttctc tttggccatt gtccaagtgt tttgaactga   1980

aagggaatgt atatgaatgg tggttcagat ggaggttaga ccgttatgta gttttccacg   2040

gaatgctgtt tgcttttatt tatctggcct tgcagaagcg tcaaatactt tctgaaggaa   2100

agggtgaacc tcttttttca aacaaaattt caaattttct gttgtttatt tcagtagttt   2160

ctttcttgac ctattccatc tgggctagca gttgtaaaaa caaagcagag tgcaatgaac   2220

tccatccgtc tgtttctgtg gtacagattt tagccttcat cctaataaga aacatccctg   2280

gatatgcccg ttcagtttac agttcatttt ttgcttggtt tggaaaaatt tcattagagc   2340

tatttatttg ccagtatcac atatggctgg cagcggacac aaggggtatc ttggtactga   2400

tacctggaaa ccctatgctc aacatcattg tcagcacttt catatttgtt tgtgtggcac   2460

atgaaatttc tcagatcact aatgatcttg cacagattat tattcctaaa gataactcat   2520

ctctcttgaa aaggttggca tgtatagctg catttttttg tggactcctc atcttatcat   2580

ccattcaaga taaatcaaaa cattaggttc caaaaattct aaaaaaccta aactcttcag   2640

gctacctttg tgtgtctcta gaagagaaaa gcatctatct ggagatataa atgtgtatgt   2700

aaatataaac gtttgtggca agaggacagt tctgtgacat ctgttgaaca tatgtggttg   2760

tatatattgg aaatgtacat atccaatatg aaatactaaa acaaacaaac aaacaaaaaa   2820

ccagaatgca ttgtatagga ttgcatgtga agtcttttct actgaatcta tatttccatt   2880

tgtaagtgat tttaagttaa catatgaagg cagggaaatg attacctttc cagtaaaaag   2940

tatagataat ttaattaact tagtgacacc accaagtgtt ttgatataac taaatttgtg   3000

gtaataagac tgtctgcacc tgtattcatt gtggaacttc ctctttcatt ggaaactttc   3060

ttactcaaga atgacggcag tattgttttc ttatatgtgc aatgaagtgg aatgataaac   3120

agtatgcctt taatttatat gtgttcttgt tctgatgttg tttcctgaaa tgatttttct   3180

tcctaactgt ggttttcggg tatgcaagcc taaatctttg tacactttgt ctcacagaat   3240

agttctgagg ctccatgaca gggttttgtc attgttgatg ttattgttgc ttcgttttat   3300

aaaaaagcca aaattttttt ttccaatcca aacgttcacc tgtttccttt cctcaagcta   3360

taccagtgta ataccagtta ccctgtggat ccatttaata tgttatcccc actaattaat   3420

tttcgtatat tatttccaat atttggaaag ctctttatag ccatttggta tttcctatta   3480

cccacctcct attttaaata tttatcagtc taaacttgtg cagtgtagta aacatgcaag   3540

ttgttatgat tgagctgtat taccataagt agaattttaa gtaaactggt gaatttgggc   3600

catagatgtt tttgcttttt gtttgatttt tttttacaag ctaactgtta gaggtataca   3660

tttatttatc tgttgtacag atttgattat gattttaatg tttgaaagat tgcacttgtt   3720

tgcttttact atatgtgggg taaaatatat tttctgttca cagtatatga aaatatggag   3780

taatttaaac agtaaataaa cattctgtgg atgcttaaaa aaaaaaaaaa aaaaaaaaaa   3840

aaaaaaaaaa aaaaaaaaaa aaaaagaaaa aaaaaaaaaa aaa                     3883


<210>  1130
<211>  797
<212>  PRT
<213>  Homosapiens

<400>  1130

Met Ala Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr 
1               5                   10                  15      


Phe Ser Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu 
            20                  25                  30          


Leu Ala Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser 
        35                  40                  45              


Cys Glu Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp 
    50                  55                  60                  


Gln Pro His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys 
65                  70                  75                  80  


Asn Cys Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile 
                85                  90                  95      


Arg Gln Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys 
            100                 105                 110         


Glu Glu Gly Asn Lys His Glu Asn Ile Pro Phe Glu Asp Lys Thr Ala 
        115                 120                 125             


Ser Val Lys Val Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met 
    130                 135                 140                 


Lys Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His 
145                 150                 155                 160 


Val Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly 
                165                 170                 175     


Ser Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala 
            180                 185                 190         


Pro Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu 
        195                 200                 205             


Gln Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile 
    210                 215                 220                 


Thr Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu 
225                 230                 235                 240 


Asn Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val 
                245                 250                 255     


Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu 
            260                 265                 270         


His Leu Pro Glu Ser Ser Arg Glu Thr Thr Ala Met Ile Leu Met Asn 
        275                 280                 285             


Val Tyr Cys Asn Lys Ile Leu Lys Pro Val Asp Gly Ser Cys Cys Gln 
    290                 295                 300                 


Pro Arg Pro Pro Val Thr Leu Ile Gln Lys Leu Ala Ala Cys Phe Phe 
305                 310                 315                 320 


Thr Leu Ser Ile Ile Gly Tyr Leu Ile Phe Tyr Ile Ile His Arg Asn 
                325                 330                 335     


Ala His Arg Lys Asn Lys Pro Cys Thr Asp Leu Glu Ser Gly Glu Glu 
            340                 345                 350         


Lys Lys Asn Ile Ile Asn Thr Pro Val Ser Ser Leu Glu Ile Leu Leu 
        355                 360                 365             


Gln Ser Phe Cys Lys Leu Gly Leu Ile Met Ala Tyr Phe Tyr Met Cys 
    370                 375                 380                 


Asp Ser Ala Asn Leu Phe Met Lys Glu Asn Lys Phe Tyr Thr His Ser 
385                 390                 395                 400 


Ser Phe Phe Ile Pro Ile Ile Tyr Ile Leu Val Leu Gly Val Phe Tyr 
                405                 410                 415     


Asn Glu Asn Thr Lys Glu Thr Lys Val Leu Asn Arg Glu Gln Thr Asp 
            420                 425                 430         


Glu Trp Lys Gly Trp Met Gln Leu Val Ile Leu Ile Tyr His Ile Ser 
        435                 440                 445             


Gly Ala Ser Thr Phe Leu Pro Val Tyr Met His Ile Arg Val Leu Val 
    450                 455                 460                 


Ala Ala Tyr Leu Phe Gln Thr Gly Tyr Gly His Phe Ser Tyr Phe Trp 
465                 470                 475                 480 


Ile Lys Gly Asp Phe Gly Ile Tyr Arg Val Cys Gln Val Leu Phe Arg 
                485                 490                 495     


Leu Asn Phe Leu Val Val Val Leu Cys Ile Val Met Asp Arg Pro Tyr 
            500                 505                 510         


Gln Phe Tyr Tyr Phe Val Pro Leu Val Thr Val Trp Phe Met Val Ile 
        515                 520                 525             


Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln Lys Lys Ala Asn 
    530                 535                 540                 


Gly Asn Cys Phe Trp His Phe Gly Leu Leu Leu Lys Leu Gly Phe Leu 
545                 550                 555                 560 


Leu Leu Phe Ile Cys Phe Leu Ala Tyr Ser Gln Gly Ala Phe Glu Lys 
                565                 570                 575     


Ile Phe Ser Leu Trp Pro Leu Ser Lys Cys Phe Glu Leu Lys Gly Asn 
            580                 585                 590         


Val Tyr Glu Trp Trp Phe Arg Trp Arg Leu Asp Arg Tyr Val Val Phe 
        595                 600                 605             


His Gly Met Leu Phe Ala Phe Ile Tyr Leu Ala Leu Gln Lys Arg Gln 
    610                 615                 620                 


Ile Leu Ser Glu Gly Lys Gly Glu Pro Leu Phe Ser Asn Lys Ile Ser 
625                 630                 635                 640 


Asn Phe Leu Leu Phe Ile Ser Val Val Ser Phe Leu Thr Tyr Ser Ile 
                645                 650                 655     


Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn Glu Leu His Pro 
            660                 665                 670         


Ser Val Ser Val Val Gln Ile Leu Ala Phe Ile Leu Ile Arg Asn Ile 
        675                 680                 685             


Pro Gly Tyr Ala Arg Ser Val Tyr Ser Ser Phe Phe Ala Trp Phe Gly 
    690                 695                 700                 


Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His Ile Trp Leu Ala 
705                 710                 715                 720 


Ala Asp Thr Arg Gly Ile Leu Val Leu Ile Pro Gly Asn Pro Met Leu 
                725                 730                 735     


Asn Ile Ile Val Ser Thr Phe Ile Phe Val Cys Val Ala His Glu Ile 
            740                 745                 750         


Ser Gln Ile Thr Asn Asp Leu Ala Gln Ile Ile Ile Pro Lys Asp Asn 
        755                 760                 765             


Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala Phe Phe Cys Gly 
    770                 775                 780                 


Leu Leu Ile Leu Ser Ser Ile Gln Asp Lys Ser Lys His 
785                 790                 795         


<210>  1131
<211>  1658
<212>  DNA
<213>  Homosapiens

<400>  1131
aagctgggag ggaagaagaa agggagggga ggggagaatc gaggacggac ggcctagcca     60

ggccaagaat gcaattgccc cggtggtggg agctgggaga cccctgtgct tggacgggac    120

agggtcgggg gacacgcagg atgagccccg cgaccactgg cacattcttg ctgacagtgt    180

acagtatttt ctccaaggta cactccgatc ggaatgtata cccatcagca ggtgtcctct    240

ttgttcatgt tttggaaaga gaatatttta agggggaatt tccaccttac ccaaaacctg    300

gcgagattag taatgatccc ataacattta atacaaattt aatgggttac ccagaccgac    360

ctggatggct tcgatatatc caaaggacac catatagtga tggagtccta tatgggtccc    420

caacagctga aaatgtgggg aagccaacaa tcattgagat aactgcctac aacaggcgca    480

cctttgagac tgcaaggcat aatttgataa ttaatataat gtctgcagaa gacttcccgt    540

tgccatatca agcagaattc ttcattaaga atatgaatgt agaagaaatg ttggccagtg    600

aggttcttgg agactttctt ggcgcagtga aaaatgtgtg gcagccagag cgcctgaacg    660

ccataaacat cacatcggcc ctagacaggg gtggcagggt gccacttccc attaatgacc    720

tgaaggaggg cgtttatgtc atggttggtg cagatgtccc gttttcttct tgtttacgag    780

aagttgaaaa tccacagaat caattgagat gtagtcaaga aatggagcct gtaataacat    840

gtgataaaaa atttcgtact caattttaca ttgactggtg caaaatttca ttggttgata    900

aaacaaagca agtgtccacc tatcaggaag tgattcgtgg agaggggatt ttacctgatg    960

gtggagaata caaaccccct tctgattctt tgaaaagcag agactattac acggatttcc   1020

taattacact ggctgtgccc tcggcagtgg cactggtcct ttttctaata cttgcttata   1080

tcatgtgctg ccgacgggaa ggcgtggaaa agagaaacat gcaaacacca gacatccaac   1140

tggtccatca cagtgctatt cagaaatcta ccaaggagct tcgagacatg tccaagaata   1200

gagagatagc atggcccctg tcaacgcttc ctgtgttcca ccctgtgact ggggaaatca   1260

tacctccttt acacacagac aactatgata gcacaaacat gccattgatg caaacgcagc   1320

agaacttgcc acatcagact cagattcccc aacagcagac tacaggtaaa tggtatccct   1380

gaagaaagaa aactgactga agcaatgaat ttataatcag acaatatagc agttacatca   1440

catttctttt ctcttccaat aatgcatgag cttttctggc atatgttatg catgttggca   1500

gtattaagtg tataccaaat aatacaacat aactttcatt ttactaatgt atttttttgt   1560

acttaaagca tttttgacaa tttgtaaaac attgatgact ttatatttgt tacaataaaa   1620

gttgatcttt aaaataaata ttattaatga aaaaaaag                           1658


<210>  1132
<211>  437
<212>  PRT
<213>  Homosapiens

<400>  1132

Met Gln Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr 
1               5                   10                  15      


Gly Gln Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr 
            20                  25                  30          


Phe Leu Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg 
        35                  40                  45              


Asn Val Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg 
    50                  55                  60                  


Glu Tyr Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile 
65                  70                  75                  80  


Ser Asn Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp 
                85                  90                  95      


Arg Pro Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly 
            100                 105                 110         


Val Leu Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile 
        115                 120                 125             


Ile Glu Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His 
    130                 135                 140                 


Asn Leu Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr 
145                 150                 155                 160 


Gln Ala Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala 
                165                 170                 175     


Ser Glu Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln 
            180                 185                 190         


Pro Glu Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly 
        195                 200                 205             


Gly Arg Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val 
    210                 215                 220                 


Met Val Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu 
225                 230                 235                 240 


Asn Pro Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile 
                245                 250                 255     


Thr Cys Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys 
            260                 265                 270         


Ile Ser Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val 
        275                 280                 285             


Ile Arg Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro 
    290                 295                 300                 


Ser Asp Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr 
305                 310                 315                 320 


Leu Ala Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala 
                325                 330                 335     


Tyr Ile Met Cys Cys Arg Arg Glu Gly Val Glu Lys Arg Asn Met Gln 
            340                 345                 350         


Thr Pro Asp Ile Gln Leu Val His His Ser Ala Ile Gln Lys Ser Thr 
        355                 360                 365             


Lys Glu Leu Arg Asp Met Ser Lys Asn Arg Glu Ile Ala Trp Pro Leu 
    370                 375                 380                 


Ser Thr Leu Pro Val Phe His Pro Val Thr Gly Glu Ile Ile Pro Pro 
385                 390                 395                 400 


Leu His Thr Asp Asn Tyr Asp Ser Thr Asn Met Pro Leu Met Gln Thr 
                405                 410                 415     


Gln Gln Asn Leu Pro His Gln Thr Gln Ile Pro Gln Gln Gln Thr Thr 
            420                 425                 430         


Gly Lys Trp Tyr Pro 
        435         


<210>  1133
<211>  6661
<212>  DNA
<213>  Homosapiens

<400>  1133
atgtgccaca aactgacgga tgggcgcttc agtggcgcta caatccagaa cgaggagcag     60

cgatatagga gctgcagaca gaaaactgaa ttgcgcttta catgcgctgc aaaatctgag    120

ctgcagaaga gtagcactac aaaaaacgct acaaaaacga tgcgattagc cagcccgaca    180

acagcgcttc attgcgctgc gaggcacatg aactgcagag gtttttttag aggcactagt    240

ggacctttgg gaatcggatg ttttggtgga tacaaaattg gtgctgttgg tttggcctct    300

gaaaataagc gggttttgaa aacaaaaaaa agaaggagtg gaagaggggg ccaggatcca    360

ggcctccatc cccacagaag tgaagctaca gctgggaggt ctcctcccac cccaaccgtc    420

accctgggtc ccgactgccc acctcctcct cctccccctc cccccaacaa caacaacaac    480

aacaactcca agcacaccgg ccataagagt gcgtgtgtcc ccaacatgac cgaacgaaga    540

agggacgagc tctctgaaga gatcaacaac ttaagagaga aggtcatgaa gcagtcggag    600

gagaacaaca acctgcagag ccaggtgcag aagctcacag aggagaacac cacccttcga    660

gagcaagtgg aacccacccc tgaggatgag gatgatgaca tcgagctccg cggtgctgca    720

gcagctgctg ccccaccccc tccaatagag gaagagtgcc cagaagacct cccagagaag    780

ttcgatggca acccagacat gctggctcct ttcatggccc agtgccagat cttcatggaa    840

aagagcacca gggatttctc agttgatcgt gtccgtgtct gcttcgtgac aagcatgatg    900

accggccgtg ctgcccgttg ggcctcagca aagctggagc gctcccacta cctgatgcac    960

aactacccag ctttcatgat ggaaatgaag catgtctttg aagaccctca gaggcgagag   1020

gttgccaaac gcaagatcag acgcctgcgc caaggcatgg ggtctgtcat cgactactcc   1080

aatgctttcc agatgattgc ccaggacctg gattggaacg agcctgcgct gattgaccag   1140

taccacgagg gcctcagcga ccacattcag gaggagctct cccacctcga ggtcgccaag   1200

tcgctgtctg ctctgattgg gcagtgcatt cacattgaga gaaggctggc cagggctgct   1260

gcagctcgca agccacgctc gccaccccgg gcgctggtgt tgcctcacat tgcaagccac   1320

caccaggtag atccaaccga gccggtggga ggtgcccgca tgcgcctgac gcaggaagaa   1380

aaagaaagac gcagaaagct gaacctgtgc ctctactgtg gaacaggagg tcactacgct   1440

gacaattgtc ctgccaaggc ctcaaagtct tcgccggcgg gaaactcccc ggccccgctg   1500

tagagggacc ttcagcgacc gggccagaaa taataaggtc cccacaagat gatgcctcat   1560

ctccacactt gcaagtgatg ctccagattc atcttccggg cagacacacc ctgttcgtcc   1620

gagccatgat cgattctggt gcttctggca acttcattga tcacgaatat gttgctcaaa   1680

atggaattcc tctaagaatc aaggactggc caatacttgt ggaagcaatt gatgggcgcc   1740

ccatagcatc gggcccagtt gtccacgaaa ctcacgacct gatagttgac ctgggagatc   1800

accgagaggt gctgtcattt gatgtgactc agtctccatt cttccctgtc gtcctagggg   1860

ttcgctggct gagcacacat gatcccaata tcacatggag cactcgatct atcgtctttg   1920

attctgaata ctgccgctac cactgccgga tgtattctcc aataccacca tcgctcccac   1980

caccagcacc acaaccgcca ctctattatc cagtagatgg atacagagtt taccaaccag   2040

tgaggtatta ctatgtccag aatgtgtaca ctccagtaga tgagcacgtc tacccagatc   2100

accgcctggt tgaccctcac atagaaatga tacctggagc acacagtatt cccagtggac   2160

atgtgtattc actgtccgaa cctgaaatgg cagctcttcg agattttgtg gcaagaaatg   2220

taaaagatgg gctaattact ccaacgattg cacctaatgg agcccaagtt ctccaggtga   2280

agagggggtg gaaactgcaa gtttcttatg attgccgagc tccaaacaat tttactatcc   2340

agaatcagta tcctcgccta tctattccaa atttagaaga ccaagcacac ctggcaacgt   2400

acactgaatt cgtacctcaa atacctggat accaaacata ccccacatat gccgcgtacc   2460

cgacctaccc agtaggattc gcctggtacc cagtgggacg agacggacaa ggaagatcac   2520

tatatgtacc tgtgatgatc acttggaatc cacactggta ccgccagcct ccggtaccac   2580

agtacccgcc gccacagccg ccgcctccac caccaccacc gccgccgcct ccatcttaca   2640

gtaccctgta aatacctgtc atgtccttca ggatctctgc cctcaaaatt tattcctgtt   2700

cagcttctca atcagtgact gtgtgctaaa ttttaggcta ctgtatcttc aggccacctg   2760

aggcacatcc tctctgaaac ggctatggaa ggttagggcc actctggact ggcacacatc   2820

ctaaagcacc aaaagacctt caacattttc tgagagcaac agagtatttg ccaataaatg   2880

atctctcatt tttccacctt gactgccaat ctaactaaaa taattaataa gtttactttc   2940

cagccagtcc tggaagtctg ggttttacct gccaaaacct ccatcaccat ctaaattata   3000

ggctgccaaa tttgctgttt aacatttaca gagaagctga tacaaacgca ggaaatgctg   3060

atttctttat ggagggggag acgaggagga ggaggacatg acttttcttg cggtttcggt   3120

accctctttt taaatcactg gaggactgag gccttattaa ggaagccaaa attatcggtg   3180

cagtgtggaa aggcttccgt gatcctctcg ctgcaccctt agaaacttca ccgtcttcaa   3240

actccatttc catggttctg ttaattctca aggagcagca actcgactgg ttctcccagg   3300

agcaggaaaa acccttgtga catgaaacat ctcaggcctg aaaagaaagt gctctctcag   3360

atggactctt gcatgttaag actatgtctt cacatcatgg tgcaaatcac atgtacccaa   3420

tgactccggc tttgacacaa caccttacca tcatcatgcc atgatggctt ccacaaagca   3480

ttaaacctgg taaccagaga ttactggtgg ctccagcgtt gttagatgtt catgaaatgt   3540

gaccacctct caatcacctt tgagggctaa agagtagcac atcaaaagga ctccaaaatc   3600

ccatacccaa ctcttaagag atttgtcctg gtacttcaga aagaattttc atgagtgttc   3660

ttaattggct ggaaaagcac cagctgacgt tttggaagaa tctatccatg tgtctgcctc   3720

catatgcatc tgggcatttc atcttcagtc ccctcattag actgtagcat taggatgtgt   3780

ggagagagga gaaatgattt agcacccaga ttcacactcc tatgcctgga agggggacat   3840

ctttgaagaa gaggaattag ggctgtggac actgtcttga ggatgtggac ttccttagtg   3900

agctccacat tacttgatgg taaccacttc aaaaggatca gaatccacgt aatgaaaaag   3960

gtccctctag aggatggagc tgatgtgaag ctgccaatgg atgaaaagcc tcagaaagca   4020

actcaaagga ctcaaagcaa cggacaacac aagagttgtc ttcagcccag tgacacctct   4080

gatgtcccct ggaagctttg tgctaacctg ggactgcctg acttccttta gcctggtccc   4140

ttgctactac cttgaactgt tttatctaac ctctcttttt ctgtttaatt ctttgctact   4200

gccattgacc ctgctgcagg atttgtgtca ttttcctgcc tggttgctga gactccattt   4260

tgctgccaca cacagagatg taagaggcag gctttaattg ccaaagcaca gtttgagcag   4320

tagaaaacaa catggtgtat atctcaaatt gcctgacatg aagaggagtc taacggtgaa   4380

gtttcacttt tcatcagcat catctttcac atgttcatta tcatctgctc ttattcttgc   4440

atgtttaaac acttaaaatt tttagtataa tttttagtgt gttttgaagt ggtgactagg   4500

ctttcaaaaa cttccattga attacaaagc actatccagt tcttattgtt aaactaagta   4560

aaaatgataa gtaacatagt gtaaaatatt cctttactgt gaacttctta caatgctgtg   4620

aatgagaggc tcctcagaac tggagcattt gtataataat tcatcctgtt catcttcaat   4680

tttaacatca tatataattt caattctatc aattgggcct ttaaaaatca tataaaagga   4740

tataaaattt gaaaagagaa acctaattgg ctatttaatc caaaacaact ttttttttcc   4800

ttcaatggaa tcagaaagct tgtcaatcac tcatgtgttt tagagtaatt acttttaaaa   4860

tggtgcattt gtgcttctga actattttga agagtcactt ctgtttacct caagtatcaa   4920

ttcatcctcc atacatttga attcaagttg tttttttgtc aaatttacag ttgtcaattg   4980

atcttcaagc tgcagggtgc ctagaaatgg gccgttgtct gtagccctgg catgtgcaca   5040

cggacatttg ccaccactgc aagcaaaagt ctggagaagt tcaccaacga caagaacgat   5100

tagggaaaat atgctgctgt gggttaacaa ctcagaaagt ccctgatcca catttggctg   5160

tttactaaag cttgtgatta actttttggc agtgtgtact atgctctatt gctatatatg   5220

ctatctataa atgtagatgt taaggataag taattctaaa tttattattc tatagttttg   5280

aagtttggtt aagtttcctt tcactcaatt gatttatttt gttgttaatc aaatttatgt   5340

taattggatc ctttaaattt tttttggcat tttccaacaa aaatggcttt attcataaga   5400

aaggaaaaaa atcaatggaa tttgatatct aaagaagtta gaaagggagc aaaataaaaa   5460

acataaagga gatagatgaa ttagtaagca aatcagtagt cgagtttttc aaactggcaa   5520

aattaattaa ttgactttta gcccaaattt acattgttaa ttaaatcaag aaggaagaag   5580

atctaagagc tcccattgat aggcaagcct agagagaact agctaaattt atcatgctag   5640

gatattgaaa cacagaaagt ttacatacat ttatgaaggg tcaatttagt ttggacagtg   5700

aggtatttgt cttagtggaa aaaaggagaa ttagtctgat caaatcgtga agtaatacag   5760

tgaacttgca ggtgcacaaa ataagagggc cacatctata tggtgcagtc tggaattctg   5820

tttaagtttg taggtacctc ttggacttct gaattgatcc agttgtcatc caccacagac   5880

atctcacatc agatacagac agttccaaga ttgacaacag agaacaacct gctggaaaga   5940

cctgggcaga aatggagagc cctgcgggaa ccatgctaca ttttcatcta aagagagaat   6000

gcacatctga tgagactgaa agttctttgt tgttttagat tgtagaatgg tattgaattg   6060

gtctgtggaa aattgcattg cttttatttc tttgtgtaat caagtttaag taatagggga   6120

tatataatca taagcatttt agggtgggag ggactattaa gtaattttaa gtgggtgggg   6180

ttatttagaa tgttagaata atattatgta ttagatatcg ctataagtgg acatgcgtac   6240

ttacttgtaa ccctttaccc tataattgct atccttaaag atttcaaata aactcggagg   6300

gaactgcagg gagaccaact tatttagagc gaattggaca tggataaaaa ccccagtggg   6360

agaaagttca aaggtgatta gattaataat ttaatagagg atgagtgacc tctgataaat   6420

tactgctaga atgaacttgt caatgatgga tggtaaattt tcatggaagt tataaaagtg   6480

ataaataaaa acccttgctt ttacccctgt cagtagccct cctcctacca ctgaacccca   6540

ttgcccctac ccctccttct aactttattg ctgtattctc ttcactctat atttctctct   6600

atttgctaat attgcattgc tgttacaata aaaattcaat aaagatttag tggttaagtg   6660

c                                                                   6661


<210>  1134
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  1134

Met Cys His Lys Leu Thr Asp Gly Arg Phe Ser Gly Ala Thr Ile Gln 
1               5                   10                  15      


Asn Glu Glu Gln Arg Tyr Arg Ser Cys Arg Gln Lys Thr Glu Leu Arg 
            20                  25                  30          


Phe Thr Cys Ala Ala Lys Ser Glu Leu Gln Lys Ser Ser Thr Thr Lys 
        35                  40                  45              


Asn Ala Thr Lys Thr Met Arg Leu Ala Ser Pro Thr Thr Ala Leu His 
    50                  55                  60                  


Cys Ala Ala Arg His Met Asn Cys Arg Gly Phe Phe Arg Gly Thr Ser 
65                  70                  75                  80  


Gly Pro Leu Gly Ile Gly Cys Phe Gly Gly Tyr Lys Ile Gly Ala Val 
                85                  90                  95      


Gly Leu Ala Ser Glu Asn Lys Arg Val Leu Lys Thr Lys Lys Arg Arg 
            100                 105                 110         


Ser Gly Arg Gly Gly Gln Asp Pro Gly Leu His Pro His Arg Ser Glu 
        115                 120                 125             


Ala Thr Ala Gly Arg Ser Pro Pro Thr Pro Thr Val Thr Leu Gly Pro 
    130                 135                 140                 


Asp Cys Pro Pro Pro Pro Pro Pro Pro Pro Pro Asn Asn Asn Asn Asn 
145                 150                 155                 160 


Asn Asn Ser Lys His Thr Gly His Lys Ser Ala Cys Val Pro Asn Met 
                165                 170                 175     


Thr Glu Arg Arg Arg Asp Glu Leu Ser Glu Glu Ile Asn Asn Leu Arg 
            180                 185                 190         


Glu Lys Val Met Lys Gln Ser Glu Glu Asn Asn Asn Leu Gln Ser Gln 
        195                 200                 205             


Val Gln Lys Leu Thr Glu Glu Asn Thr Thr Leu Arg Glu Gln Val Glu 
    210                 215                 220                 


Pro Thr Pro Glu Asp Glu Asp Asp Asp Ile Glu Leu Arg Gly Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Pro Pro Pro Pro Ile Glu Glu Glu Cys Pro Glu Asp 
                245                 250                 255     


Leu Pro Glu Lys Phe Asp Gly Asn Pro Asp Met Leu Ala Pro Phe Met 
            260                 265                 270         


Ala Gln Cys Gln Ile Phe Met Glu Lys Ser Thr Arg Asp Phe Ser Val 
        275                 280                 285             


Asp Arg Val Arg Val Cys Phe Val Thr Ser Met Met Thr Gly Arg Ala 
    290                 295                 300                 


Ala Arg Trp Ala Ser Ala Lys Leu Glu Arg Ser His Tyr Leu Met His 
305                 310                 315                 320 


Asn Tyr Pro Ala Phe Met Met Glu Met Lys His Val Phe Glu Asp Pro 
                325                 330                 335     


Gln Arg Arg Glu Val Ala Lys Arg Lys Ile Arg Arg Leu Arg Gln Gly 
            340                 345                 350         


Met Gly Ser Val Ile Asp Tyr Ser Asn Ala Phe Gln Met Ile Ala Gln 
        355                 360                 365             


Asp Leu Asp Trp Asn Glu Pro Ala Leu Ile Asp Gln Tyr His Glu Gly 
    370                 375                 380                 


Leu Ser Asp His Ile Gln Glu Glu Leu Ser His Leu Glu Val Ala Lys 
385                 390                 395                 400 


Ser Leu Ser Ala Leu Ile Gly Gln Cys Ile His Ile Glu Arg Arg Leu 
                405                 410                 415     


Ala Arg Ala Ala Ala Ala Arg Lys Pro Arg Ser Pro Pro Arg Ala Leu 
            420                 425                 430         


Val Leu Pro His Ile Ala Ser His His Gln Val Asp Pro Thr Glu Pro 
        435                 440                 445             


Val Gly Gly Ala Arg Met Arg Leu Thr Gln Glu Glu Lys Glu Arg Arg 
    450                 455                 460                 


Arg Lys Leu Asn Leu Cys Leu Tyr Cys Gly Thr Gly Gly His Tyr Ala 
465                 470                 475                 480 


Asp Asn Cys Pro Ala Lys Ala Ser Lys Ser Ser Pro Ala Gly Asn Ser 
                485                 490                 495     


Pro Ala Pro Leu 
            500 


<210>  1135
<211>  360
<212>  DNA
<213>  Homosapiens

<400>  1135
atggcagttg gcaagaacaa gtgctttatg aaaggcagca aaaagggagc caagaagaaa     60

gtgattgatc aattttctaa gaaagattgg tatgatgtga aagcacttgc tatgttcaat    120

ataagaaata ttggaaagac gccatcacca ggacccaagg aaccaaaatt gcatctgatg    180

gtctcaaggg tcatgtgttt gaaaaaagta aaaatgctga agaagcccaa gtttgaattg    240

ggaaagctca tggagcttca tggtgacagc agtagttctg gaaaagccat tggggatgag    300

acaggtgcta aagttgaacg agctgaggga tatgaaccac cagtccaaga atctgtttaa    360


<210>  1136
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  1136

Met Ala Val Gly Lys Asn Lys Cys Phe Met Lys Gly Ser Lys Lys Gly 
1               5                   10                  15      


Ala Lys Lys Lys Val Ile Asp Gln Phe Ser Lys Lys Asp Trp Tyr Asp 
            20                  25                  30          


Val Lys Ala Leu Ala Met Phe Asn Ile Arg Asn Ile Gly Lys Thr Pro 
        35                  40                  45              


Ser Pro Gly Pro Lys Glu Pro Lys Leu His Leu Met Val Ser Arg Val 
    50                  55                  60                  


Met Cys Leu Lys Lys Val Lys Met Leu Lys Lys Pro Lys Phe Glu Leu 
65                  70                  75                  80  


Gly Lys Leu Met Glu Leu His Gly Asp Ser Ser Ser Ser Gly Lys Ala 
                85                  90                  95      


Ile Gly Asp Glu Thr Gly Ala Lys Val Glu Arg Ala Glu Gly Tyr Glu 
            100                 105                 110         


Pro Pro Val Gln Glu Ser Val 
        115                 


<210>  1137
<211>  1530
<212>  DNA
<213>  Homosapiens

<400>  1137
actcaatgtc ggaacgttcc gaagatgacg tcggagcgtt ctcgaatccc gtgtctctcg     60

gctgctgctg ccgaaggaac agggaaaaag caacaagaag gaagagcaat ggcgacactg    120

gatcgcaaag tgcccagtcc ggaggcgttt ctgggcaaac cctggtcctc ctggatcgac    180

gccgccaaat tacactgctc cgacaatgta gatttagaag aggctggaaa agagggtgga    240

aaaagcaggg aggttatgag gcttaataaa gaagatatgc acttatttgg ccattaccca    300

gcacatgacg acttctatct cgtagtgtgc agtgcctgta accaggtcgt caagccacag    360

gttttccagt cgcactgcgg gagaaagcaa gacaacagga gaaatgaagg catctccagg    420

agtggaccag agagcagcca agccatagag aagcatcagg tgtgagaatg gaaaacgcag    480

aagagacgta caacttctga aagatctcag aggactggca ttgtctggag acggcttcct    540

ggaagaggag actccagcag agccctgaag tgtggacaag cttccattca ctgcaaattc    600

gtgagcacac tctggtgtca ggatctagta aggaaatggg cttgagcaga gcagggggta    660

cctgtggggt tcttctcttc attttcacca ccacaaagct ggtctaagct gccatcaatt    720

cccacctgga caactgcaaa agccttccag ctgttcctgc ttccactctt gctcctctac    780

aattcattct gcacgcagaa gtcagaatca aaatcaaagt tcatcatgtc attctcttga    840

cttgtggctt ccctttgctc ttaagctaaa agtaaaaatc attatcatgg ctacaaagtc    900

ttgtgtggtc tgggccacat cctgtgccag gctccctttc attgtctata ttccagtcaa    960

gctggccttc aaaatttcag cacattgggt ctttctgcca caggcccttg cacatacatg   1020

cttttccctc tgtacatgtg attttctttc atccccgctt tccaaagcta actctgactc   1080

atccttcaga ctgcatctta atgattactt ccttctggaa gactccccta attttcacaa   1140

ctagatgagc tctcccttat atgttgaaaa caagtatttc ttgtgtgaac agaaatgttt   1200

aatgtctgcc ttcccaactc agccacaagc tctgtgagga tggggactca gtctttgcat   1260

ccctcagagc ctagcatagt ctcagttaat acgtgatagc tggagcgtga catttcatta   1320

ggaacagtga ggctagttga gaaattatac ctcaccagta tataggagag taccattagg   1380

aattcttaat gggatgaaaa cctgaattca tgtctagacc ctgccacctg ctggctgtgc   1440

tgttttaaat aaattgcaga tcctctcaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500

aaaaaaaaaa aaagaaaaaa aaaaaaaaaa                                    1530


<210>  1138
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  1138

Met Thr Ser Glu Arg Ser Arg Ile Pro Cys Leu Ser Ala Ala Ala Ala 
1               5                   10                  15      


Glu Gly Thr Gly Lys Lys Gln Gln Glu Gly Arg Ala Met Ala Thr Leu 
            20                  25                  30          


Asp Arg Lys Val Pro Ser Pro Glu Ala Phe Leu Gly Lys Pro Trp Ser 
        35                  40                  45              


Ser Trp Ile Asp Ala Ala Lys Leu His Cys Ser Asp Asn Val Asp Leu 
    50                  55                  60                  


Glu Glu Ala Gly Lys Glu Gly Gly Lys Ser Arg Glu Val Met Arg Leu 
65                  70                  75                  80  


Asn Lys Glu Asp Met His Leu Phe Gly His Tyr Pro Ala His Asp Asp 
                85                  90                  95      


Phe Tyr Leu Val Val Cys Ser Ala Cys Asn Gln Val Val Lys Pro Gln 
            100                 105                 110         


Val Phe Gln Ser His Cys Gly Arg Lys Gln Asp Asn Arg Arg Asn Glu 
        115                 120                 125             


Gly Ile Ser Arg Ser Gly Pro Glu Ser Ser Gln Ala Ile Glu Lys His 
    130                 135                 140                 


Gln Val 
145     


<210>  1139
<211>  3811
<212>  DNA
<213>  Homosapiens

<400>  1139
actggaaaac tttgggtgtg agacgggatt caggctgtgg ctaatgtgct ggaagcacgc     60

acagttgtga ccatcaagta tgcaggaagc aatcattctc ctggctctcc tgggtgccat    120

gtcaggggga gaagcactac acctaatcct cttacctgct acaggcaatg tggcagagaa    180

ttctccacct gggacttcag tgcacaagtt ttctgtgaag ttatcagcat cattgtcacc    240

tgtgatccca ggatttcccc agatagtcaa ctcaaatccc ctcactgaag cttttagggt    300

gaattggctg tcaggcacct actttgaggt tgtcaccact gggatggaac aactagattt    360

tgaaacagga ccaaacatat ttgatttgca gatttatgtg aaggatgagg ttggtgtcac    420

agacctgcaa gtcctgactg tccaggtaac agatgtgaac gagccacctc agtttcaagg    480

caacttggca gaaggtctac acctctacat agtagaaaga gcaaaccctg gattcattta    540

ccaggttgag gccttcgatc cagaagacac aagccgaaac attcccctca gttatttcct    600

gatttctccc ccaaagagct tcagaatgtc tgctaatggc accctcttct ccacaacaga    660

attggacttt gaagcaggac acagaagttt ccatctcatc gtggaggtga gggacagtgg    720

aggcctcaaa gcctccacag agctccaggt gaacatcgtg aacctcaacg acgaagtccc    780

tcgctttacc agcccgacac gagtgtacac agtcctggag gaactgagtc caggaaccat    840

cgtggccaat atcacagcgg aggatcctga tgatgaaggt tttcccagcc acctcctcta    900

cagcattacc actgttagca aatatttcat gataaatcag ttgactggta caatccaagt    960

ggcccaaagg atagaccgag atgcaggtga attgagacaa aatcccacca tttccctgga   1020

agttctagtg aaggacagac catatggggg tcaggagaat cgcatccaga taaccttcat   1080

tgtggaagac gtcaacgaca atcctgccac atgccaaaag ttcaccttca gcattatggt   1140

gccggaaaga acagccaagg ggacgttgct tcttgaccta aacaagttct gctttgatga   1200

tgacagtgag gcaccaaaca acagattcaa cttcaccatg ccatctggag tggggagcgg   1260

cagcagattt ttacaggatc cagctggctc tgggaagatt gtgctgattg gtgatctaga   1320

ctacgaaaat ccaagtaacc tagcagccgg caataaatat acggtgataa tccaggtgca   1380

ggatgtggcc cccccttact ataaaaataa cgtctacgtt tatatcctaa caagcccaga   1440

aaatgagttt cctctcattt ttgataggcc atcctatgta tttgatgtgt cagaaagaag   1500

gcccgccaga acccgagtgg gacaggtgcg agccactgat aaagacctcc cccagagcag   1560

cctcctgtac tccatctcca ctggaggggc cagcctccag tatccaaatg tattttggat   1620

taatcccaag acaggagaac tccagctggt aactaaagtg gactgtgaaa caacccccat   1680

ctatattctc agaatccagg ccaccaacaa cgaagacaca agctctgtca ctgttactgt   1740

gaacatcctt gaagaaaatg atgaaaagcc aatttgtact ccaaactctt atttcctggc   1800

cctcccagtg gatctgaaag ttggcacaaa tattcagaat ttcaagctga catgtaccga   1860

ccttgattcc agccccagat ctttccgtta ttccattggc ccaggtaacg tcaacaatca   1920

tttcaccttc tctcccaatg ctggttccaa tgtcacacgc ctgctgctta cgtctcgctt   1980

tgactatgct ggtgggtttg ataagatctg ggactacaag ctacttgtct acgtaactga   2040

tgacaacttg atgtctgaca ggaagaaagc ggaggctctt gttgagacag gaacagtgac   2100

actgagtatt aaagtcattc cccacccaac cactatcatc accacgaccc ccaggcccag   2160

ggtcacctat caggtcctga ggaaaaacgt ttactctcca tctgcatggt acgtgccgtt   2220

tgtcatcact ttgggctcca tattgcttct gggtctcctc gtgtacctgg tcgtcctatt   2280

ggccaaagcc atccacagac actgcccctg caagactggg aagaacaagg aacctctgac   2340

aaagaaagga gaaacgaaga ctgcagagag agacgtcgtg gtggaaacta tccagatgaa   2400

cactatcttt gatggagaag ccatagatcc agtgaccggg gaaacatatg aattcaactc   2460

aaaaactgga gccagaaagt ggaaagatcc actaacccaa atgccaaaat ggaaagagtc   2520

cagccaccag ggagctgccc cacgcagagt cactgctggg gaagggatgg ggtcactgag   2580

aagtgccaac tgggaagaag atgagctgag tggcaaagcg tgggctgagg atgctggtct   2640

gggttccaga aatgagggtg gcaagctggg caacccaaag aacagaaatc cagccttcat   2700

gaacagggct taccccaaac cacacccagg aaagtaaacg gggtctaagg aggggcctgt   2760

caatcactga gatgctgcct caccctaaat tctatgggga tggtgtgggc atggtgtagg   2820

ggggaaaatg tgggctgagg ggattcagac atccagggtc aaacatggga tgtttgacaa   2880

atttttaaac aaatagaaag gggtttgatc acatagttgc gtgttctgaa atgatacagg   2940

aacattttct atcagatttc agaactacct gtgcttctga taagcaagac tgttaacttt   3000

ggggtgtgga attgttgtgt ttcttctttg cattgactgc taggaagctc tattctgttc   3060

accatagaaa gtttgtagga attcctgaca taaatagtga agactatcct tacatctggt   3120

ttccacctta ttttcctgcc ctcgttttaa catcacccag atttcttcag ttataaatat   3180

gccatacacc tttgtaagtc acctcaaatc ttcttcaaaa gaagcagaac agtgaaaaaa   3240

acagatgagt aagttaagag ttggtcatct ggaaagaaga aaactcagta ggcaccttct   3300

tttgtttttt cttgtggtgt ccggatcagc atcctgcatg tgagattcat ccacgttgtc   3360

ctgtctagca gtagttcagt tctcttcatg gttatgtctg gtttcattct atgattatat   3420

cacaatttat ctattctaca cttgggtggc agctgcttca gatttttact tttaaaaaat   3480

atacttaaaa gtgaactaca ggcagggcat gatggctcat gcctgtaatg ccagcacttt   3540

gccaaggtgg gcagatcacc taaggtcagg agttcaagat cagcctggcc tagatggcaa   3600

aaccctgtct ctactaaaaa atacaaaaat tagcttggtg tggtggtggg cacatgtaat   3660

cccagctact tgggaggctg aggtagggag aactgcttaa acctgagagg tggaggttac   3720

agtgagttga gattgtgcca ctgcactcta gcctgggtga caaagcaaga ctccatctca   3780

gaaaaaaaaa ataaaagtga attacaacac t                                  3811


<210>  1140
<211>  885
<212>  PRT
<213>  Homosapiens

<400>  1140

Met Gln Glu Ala Ile Ile Leu Leu Ala Leu Leu Gly Ala Met Ser Gly 
1               5                   10                  15      


Gly Glu Ala Leu His Leu Ile Leu Leu Pro Ala Thr Gly Asn Val Ala 
            20                  25                  30          


Glu Asn Ser Pro Pro Gly Thr Ser Val His Lys Phe Ser Val Lys Leu 
        35                  40                  45              


Ser Ala Ser Leu Ser Pro Val Ile Pro Gly Phe Pro Gln Ile Val Asn 
    50                  55                  60                  


Ser Asn Pro Leu Thr Glu Ala Phe Arg Val Asn Trp Leu Ser Gly Thr 
65                  70                  75                  80  


Tyr Phe Glu Val Val Thr Thr Gly Met Glu Gln Leu Asp Phe Glu Thr 
                85                  90                  95      


Gly Pro Asn Ile Phe Asp Leu Gln Ile Tyr Val Lys Asp Glu Val Gly 
            100                 105                 110         


Val Thr Asp Leu Gln Val Leu Thr Val Gln Val Thr Asp Val Asn Glu 
        115                 120                 125             


Pro Pro Gln Phe Gln Gly Asn Leu Ala Glu Gly Leu His Leu Tyr Ile 
    130                 135                 140                 


Val Glu Arg Ala Asn Pro Gly Phe Ile Tyr Gln Val Glu Ala Phe Asp 
145                 150                 155                 160 


Pro Glu Asp Thr Ser Arg Asn Ile Pro Leu Ser Tyr Phe Leu Ile Ser 
                165                 170                 175     


Pro Pro Lys Ser Phe Arg Met Ser Ala Asn Gly Thr Leu Phe Ser Thr 
            180                 185                 190         


Thr Glu Leu Asp Phe Glu Ala Gly His Arg Ser Phe His Leu Ile Val 
        195                 200                 205             


Glu Val Arg Asp Ser Gly Gly Leu Lys Ala Ser Thr Glu Leu Gln Val 
    210                 215                 220                 


Asn Ile Val Asn Leu Asn Asp Glu Val Pro Arg Phe Thr Ser Pro Thr 
225                 230                 235                 240 


Arg Val Tyr Thr Val Leu Glu Glu Leu Ser Pro Gly Thr Ile Val Ala 
                245                 250                 255     


Asn Ile Thr Ala Glu Asp Pro Asp Asp Glu Gly Phe Pro Ser His Leu 
            260                 265                 270         


Leu Tyr Ser Ile Thr Thr Val Ser Lys Tyr Phe Met Ile Asn Gln Leu 
        275                 280                 285             


Thr Gly Thr Ile Gln Val Ala Gln Arg Ile Asp Arg Asp Ala Gly Glu 
    290                 295                 300                 


Leu Arg Gln Asn Pro Thr Ile Ser Leu Glu Val Leu Val Lys Asp Arg 
305                 310                 315                 320 


Pro Tyr Gly Gly Gln Glu Asn Arg Ile Gln Ile Thr Phe Ile Val Glu 
                325                 330                 335     


Asp Val Asn Asp Asn Pro Ala Thr Cys Gln Lys Phe Thr Phe Ser Ile 
            340                 345                 350         


Met Val Pro Glu Arg Thr Ala Lys Gly Thr Leu Leu Leu Asp Leu Asn 
        355                 360                 365             


Lys Phe Cys Phe Asp Asp Asp Ser Glu Ala Pro Asn Asn Arg Phe Asn 
    370                 375                 380                 


Phe Thr Met Pro Ser Gly Val Gly Ser Gly Ser Arg Phe Leu Gln Asp 
385                 390                 395                 400 


Pro Ala Gly Ser Gly Lys Ile Val Leu Ile Gly Asp Leu Asp Tyr Glu 
                405                 410                 415     


Asn Pro Ser Asn Leu Ala Ala Gly Asn Lys Tyr Thr Val Ile Ile Gln 
            420                 425                 430         


Val Gln Asp Val Ala Pro Pro Tyr Tyr Lys Asn Asn Val Tyr Val Tyr 
        435                 440                 445             


Ile Leu Thr Ser Pro Glu Asn Glu Phe Pro Leu Ile Phe Asp Arg Pro 
    450                 455                 460                 


Ser Tyr Val Phe Asp Val Ser Glu Arg Arg Pro Ala Arg Thr Arg Val 
465                 470                 475                 480 


Gly Gln Val Arg Ala Thr Asp Lys Asp Leu Pro Gln Ser Ser Leu Leu 
                485                 490                 495     


Tyr Ser Ile Ser Thr Gly Gly Ala Ser Leu Gln Tyr Pro Asn Val Phe 
            500                 505                 510         


Trp Ile Asn Pro Lys Thr Gly Glu Leu Gln Leu Val Thr Lys Val Asp 
        515                 520                 525             


Cys Glu Thr Thr Pro Ile Tyr Ile Leu Arg Ile Gln Ala Thr Asn Asn 
    530                 535                 540                 


Glu Asp Thr Ser Ser Val Thr Val Thr Val Asn Ile Leu Glu Glu Asn 
545                 550                 555                 560 


Asp Glu Lys Pro Ile Cys Thr Pro Asn Ser Tyr Phe Leu Ala Leu Pro 
                565                 570                 575     


Val Asp Leu Lys Val Gly Thr Asn Ile Gln Asn Phe Lys Leu Thr Cys 
            580                 585                 590         


Thr Asp Leu Asp Ser Ser Pro Arg Ser Phe Arg Tyr Ser Ile Gly Pro 
        595                 600                 605             


Gly Asn Val Asn Asn His Phe Thr Phe Ser Pro Asn Ala Gly Ser Asn 
    610                 615                 620                 


Val Thr Arg Leu Leu Leu Thr Ser Arg Phe Asp Tyr Ala Gly Gly Phe 
625                 630                 635                 640 


Asp Lys Ile Trp Asp Tyr Lys Leu Leu Val Tyr Val Thr Asp Asp Asn 
                645                 650                 655     


Leu Met Ser Asp Arg Lys Lys Ala Glu Ala Leu Val Glu Thr Gly Thr 
            660                 665                 670         


Val Thr Leu Ser Ile Lys Val Ile Pro His Pro Thr Thr Ile Ile Thr 
        675                 680                 685             


Thr Thr Pro Arg Pro Arg Val Thr Tyr Gln Val Leu Arg Lys Asn Val 
    690                 695                 700                 


Tyr Ser Pro Ser Ala Trp Tyr Val Pro Phe Val Ile Thr Leu Gly Ser 
705                 710                 715                 720 


Ile Leu Leu Leu Gly Leu Leu Val Tyr Leu Val Val Leu Leu Ala Lys 
                725                 730                 735     


Ala Ile His Arg His Cys Pro Cys Lys Thr Gly Lys Asn Lys Glu Pro 
            740                 745                 750         


Leu Thr Lys Lys Gly Glu Thr Lys Thr Ala Glu Arg Asp Val Val Val 
        755                 760                 765             


Glu Thr Ile Gln Met Asn Thr Ile Phe Asp Gly Glu Ala Ile Asp Pro 
    770                 775                 780                 


Val Thr Gly Glu Thr Tyr Glu Phe Asn Ser Lys Thr Gly Ala Arg Lys 
785                 790                 795                 800 


Trp Lys Asp Pro Leu Thr Gln Met Pro Lys Trp Lys Glu Ser Ser His 
                805                 810                 815     


Gln Gly Ala Ala Pro Arg Arg Val Thr Ala Gly Glu Gly Met Gly Ser 
            820                 825                 830         


Leu Arg Ser Ala Asn Trp Glu Glu Asp Glu Leu Ser Gly Lys Ala Trp 
        835                 840                 845             


Ala Glu Asp Ala Gly Leu Gly Ser Arg Asn Glu Gly Gly Lys Leu Gly 
    850                 855                 860                 


Asn Pro Lys Asn Arg Asn Pro Ala Phe Met Asn Arg Ala Tyr Pro Lys 
865                 870                 875                 880 


Pro His Pro Gly Lys 
                885 


<210>  1141
<211>  2149
<212>  DNA
<213>  Homosapiens

<400>  1141
gcgccagccc cgcctgccct tcctcgccac cgggctgctc tggtctcgtc ggtcccctcc     60

tccgccccgt cgtcctgact ctctctccct cctttcctca gaggatgtcc ggcttccaga    120

tcaacctcaa cccgctcaag gagccactcg gcttcatcaa ggtcctcgag tggattgctt    180

ctatctttgc ttttgccacc tgtggaggtt ttaagggcca aacagaaatt caagtgaatt    240

gtcctcctgc agttactgag aataaaactg ttacagctac ttttggttat ccattcaggt    300

tgaatgaggc atcatttcag ccacctccag gtgtaaacat atgtgatgta aattggaaag    360

attacgtcct cataggcgat tactcttctt ctgcacaatt ctatgttacc tttgcagtct    420

ttgtgttcct gtactgcatt gctgcccttc tgctttatgt tggctacacg agtctgtatc    480

tggatagtcg taaacttcct atgatagact ttgttgttac acttgttgcc acttttttgt    540

ggttggtgag cacttcagcc tgggctaaag ctctgacaga tattaaaata gctactggtc    600

acaatattat tgatgaactt ccgccttgta agaagaaagc agtactgtgt tactttggct    660

ctgtgaccag tatgggatcc ctaaatgtat ctgtgatatt tggctttcta aatatgatac    720

tctggggagg aaatgcttgg tttgtgtaca aggagaccag cctacacagt ccatcaaata    780

catctgcccc tcatagccaa ggaggtattc cacctcctac cggaatataa ttaaagggag    840

aaatacactg tatgaagtat atgttgatac tatgacatgt tgccaacacc ttgagaagca    900

ttatttgttt ctaataaaag taatggcttt gtcaatatat tggtgggttt aaaactttgc    960

tgctttttta cataaagcct gtgcctttcc tagaaagtta agatgtaaat gtattctcac   1020

atgtaaattt gaaagttcag gggtctatta tgaaatgata cacattttta aatgaaccat   1080

aatttttttc actaagctgt ttgccttcca aagtgtttac accttaagcc ttaacatgta   1140

tcttcattca gaaaacagtt atattgtcat accatagtag gaagaaaaac ctttatttgg   1200

aatatacact actgtaagtt tgtacagatc atatacctac cacctgtctt tgcttaaaga   1260

gccttgatta cataaatatg taggaaaaaa catattgagt tcaaaattta tatctaacat   1320

tgtttatgtt atgatttttt tttaattgca aagactaggt gtatattttt ttctgttttt   1380

ctaaatgacc cgtggtactt aataggtgta ctaaaattgt gttgggagca gggatttgga   1440

aatttctgag agatgtgtag ttaatttagt aattctgttt catgagatat gatctgttat   1500

gctagtggtt taataggctt gctatgtaag tagaacgtgg ctcaactaga tatctttata   1560

tgtatgggca ttactcttag tgatatttgt ttcctgtcct ttgttgctca tgctgtttaa   1620

gtgcaggctg agacccagcc tctttgtaag tacagtaaaa taatccaccg ttttttacag   1680

accctagtca aagggttaaa aaaattaaga ttgctttcca tgtttgaaat ttaccattga   1740

gagtcaatga agttgctatt ttgagtttag cattgatatt gtgaaaataa gtgcaatttg   1800

gatttcatgt ttcttaatat tcattcttgt ttcacaaatg aatgattaag gaattatgca   1860

tcataaagga acctaagtga ggtatatgat gagtgtattg tctttgcaca cacatatagg   1920

tatattctga atacaagctt attcacattt tgcttcctaa tctttttgtt gtacagggat   1980

tcaggtttct tattcttaca acatgattgt ttatatgtga agcacatctt gctgttgcct   2040

tatttttgat gcttttattc atgacaagaa ttgtcaatat aagaatgtat atcttttttg   2100

caaccaattt aataaaggag ttgaaagaaa aaaaaaaaaa aaaaaaaaa               2149


<210>  1142
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  1142

Met Ser Gly Phe Gln Ile Asn Leu Asn Pro Leu Lys Glu Pro Leu Gly 
1               5                   10                  15      


Phe Ile Lys Val Leu Glu Trp Ile Ala Ser Ile Phe Ala Phe Ala Thr 
            20                  25                  30          


Cys Gly Gly Phe Lys Gly Gln Thr Glu Ile Gln Val Asn Cys Pro Pro 
        35                  40                  45              


Ala Val Thr Glu Asn Lys Thr Val Thr Ala Thr Phe Gly Tyr Pro Phe 
    50                  55                  60                  


Arg Leu Asn Glu Ala Ser Phe Gln Pro Pro Pro Gly Val Asn Ile Cys 
65                  70                  75                  80  


Asp Val Asn Trp Lys Asp Tyr Val Leu Ile Gly Asp Tyr Ser Ser Ser 
                85                  90                  95      


Ala Gln Phe Tyr Val Thr Phe Ala Val Phe Val Phe Leu Tyr Cys Ile 
            100                 105                 110         


Ala Ala Leu Leu Leu Tyr Val Gly Tyr Thr Ser Leu Tyr Leu Asp Ser 
        115                 120                 125             


Arg Lys Leu Pro Met Ile Asp Phe Val Val Thr Leu Val Ala Thr Phe 
    130                 135                 140                 


Leu Trp Leu Val Ser Thr Ser Ala Trp Ala Lys Ala Leu Thr Asp Ile 
145                 150                 155                 160 


Lys Ile Ala Thr Gly His Asn Ile Ile Asp Glu Leu Pro Pro Cys Lys 
                165                 170                 175     


Lys Lys Ala Val Leu Cys Tyr Phe Gly Ser Val Thr Ser Met Gly Ser 
            180                 185                 190         


Leu Asn Val Ser Val Ile Phe Gly Phe Leu Asn Met Ile Leu Trp Gly 
        195                 200                 205             


Gly Asn Ala Trp Phe Val Tyr Lys Glu Thr Ser Leu His Ser Pro Ser 
    210                 215                 220                 


Asn Thr Ser Ala Pro His Ser Gln Gly Gly Ile Pro Pro Pro Thr Gly 
225                 230                 235                 240 


Ile 
    


<210>  1143
<211>  2183
<212>  DNA
<213>  Homosapiens

<400>  1143
gagcgcacgc gtacacgcgt gcgcagggga agaccgagtg ccaggggctg aaccgcaggg     60

aagggggcgc ggcgcacgca gtatggcgcc caacatctac ttggttcgcc agcggatcag    120

tcgactcggc cagaggatgt ccggcttcca gatcaacctc aacccgctca aggagccact    180

cggcttcatc aaggtcctcg agtggattgc ttctatcttt gcttttgcca cctgtggagg    240

ttttaagggc caaacagaaa ttcaagtgaa ttgtcctcct gcagttactg agaataaaac    300

tgttacagct acttttggtt atccattcag gttgaatgag gcatcatttc agccacctcc    360

aggtgtaaac atatgtgatg taaattggaa agattacgtc ctcataggcg attactcttc    420

ttctgcacaa ttctatgtta cctttgcagt ctttgtgttc ctgtactgca ttgctgccct    480

tctgctttat gttggctaca cgagtctgta tctggatagt cgtaaacttc ctatgataga    540

ctttgttgtt acacttgttg ccactttttt gtggttggtg agcacttcag cctgggctaa    600

agctctgaca gatattaaaa tagctactgg tcacaatatt attgatgaac ttccgccttg    660

taagaagaaa gcagtactgt gttactttgg ctctgtgacc agtatgggat ccctaaatgt    720

atctgtgata tttggctttc taaatatgat actctgggga ggaaatgctt ggtttgtgta    780

caaggagacc agcctacaca gtccatcaaa tacatctgcc cctcatagcc aaggaggtat    840

tccacctcct accggaatat aattaaaggg agaaatacac tgtatgaagt atatgttgat    900

actatgacat gttgccaaca ccttgagaag cattatttgt ttctaataaa agtaatggct    960

ttgtcaatat attggtgggt ttaaaacttt gctgcttttt tacataaagc ctgtgccttt   1020

cctagaaagt taagatgtaa atgtattctc acatgtaaat ttgaaagttc aggggtctat   1080

tatgaaatga tacacatttt taaatgaacc ataatttttt tcactaagct gtttgccttc   1140

caaagtgttt acaccttaag ccttaacatg tatcttcatt cagaaaacag ttatattgtc   1200

ataccatagt aggaagaaaa acctttattt ggaatataca ctactgtaag tttgtacaga   1260

tcatatacct accacctgtc tttgcttaaa gagccttgat tacataaata tgtaggaaaa   1320

aacatattga gttcaaaatt tatatctaac attgtttatg ttatgatttt tttttaattg   1380

caaagactag gtgtatattt ttttctgttt ttctaaatga cccgtggtac ttaataggtg   1440

tactaaaatt gtgttgggag cagggatttg gaaatttctg agagatgtgt agttaattta   1500

gtaattctgt ttcatgagat atgatctgtt atgctagtgg tttaataggc ttgctatgta   1560

agtagaacgt ggctcaacta gatatcttta tatgtatggg cattactctt agtgatattt   1620

gtttcctgtc ctttgttgct catgctgttt aagtgcaggc tgagacccag cctctttgta   1680

agtacagtaa aataatccac cgttttttac agaccctagt caaagggtta aaaaaattaa   1740

gattgctttc catgtttgaa atttaccatt gagagtcaat gaagttgcta ttttgagttt   1800

agcattgata ttgtgaaaat aagtgcaatt tggatttcat gtttcttaat attcattctt   1860

gtttcacaaa tgaatgatta aggaattatg catcataaag gaacctaagt gaggtatatg   1920

atgagtgtat tgtctttgca cacacatata ggtatattct gaatacaagc ttattcacat   1980

tttgcttcct aatctttttg ttgtacaggg attcaggttt cttattctta caacatgatt   2040

gtttatatgt gaagcacatc ttgctgttgc cttatttttg atgcttttat tcatgacaag   2100

aattgtcaat ataagaatgt atatcttttt tgcaaccaat ttaataaagg agttgaaaga   2160

aaaaaaaaaa aaaaaaaaaa aaa                                           2183


<210>  1144
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  1144

Met Ala Pro Asn Ile Tyr Leu Val Arg Gln Arg Ile Ser Arg Leu Gly 
1               5                   10                  15      


Gln Arg Met Ser Gly Phe Gln Ile Asn Leu Asn Pro Leu Lys Glu Pro 
            20                  25                  30          


Leu Gly Phe Ile Lys Val Leu Glu Trp Ile Ala Ser Ile Phe Ala Phe 
        35                  40                  45              


Ala Thr Cys Gly Gly Phe Lys Gly Gln Thr Glu Ile Gln Val Asn Cys 
    50                  55                  60                  


Pro Pro Ala Val Thr Glu Asn Lys Thr Val Thr Ala Thr Phe Gly Tyr 
65                  70                  75                  80  


Pro Phe Arg Leu Asn Glu Ala Ser Phe Gln Pro Pro Pro Gly Val Asn 
                85                  90                  95      


Ile Cys Asp Val Asn Trp Lys Asp Tyr Val Leu Ile Gly Asp Tyr Ser 
            100                 105                 110         


Ser Ser Ala Gln Phe Tyr Val Thr Phe Ala Val Phe Val Phe Leu Tyr 
        115                 120                 125             


Cys Ile Ala Ala Leu Leu Leu Tyr Val Gly Tyr Thr Ser Leu Tyr Leu 
    130                 135                 140                 


Asp Ser Arg Lys Leu Pro Met Ile Asp Phe Val Val Thr Leu Val Ala 
145                 150                 155                 160 


Thr Phe Leu Trp Leu Val Ser Thr Ser Ala Trp Ala Lys Ala Leu Thr 
                165                 170                 175     


Asp Ile Lys Ile Ala Thr Gly His Asn Ile Ile Asp Glu Leu Pro Pro 
            180                 185                 190         


Cys Lys Lys Lys Ala Val Leu Cys Tyr Phe Gly Ser Val Thr Ser Met 
        195                 200                 205             


Gly Ser Leu Asn Val Ser Val Ile Phe Gly Phe Leu Asn Met Ile Leu 
    210                 215                 220                 


Trp Gly Gly Asn Ala Trp Phe Val Tyr Lys Glu Thr Ser Leu His Ser 
225                 230                 235                 240 


Pro Ser Asn Thr Ser Ala Pro His Ser Gln Gly Gly Ile Pro Pro Pro 
                245                 250                 255     


Thr Gly Ile 
            


<210>  1145
<211>  2100
<212>  DNA
<213>  Homosapiens

<400>  1145
agcgcggggc aggaggagta cctcggccaa gaaaattatg catgcgttag ggaagctctg     60

agagaatggc tgtggaagct ctccactgtg gtttgaatcc acggggtatt gatcaccctg    120

cccatgctga aggtattaaa ctgcaaattg aaggtgaagg tgtggaatct caatccatta    180

aaaataaaaa tttccagaag gtgcctgacc agaaaggaac tcccaagcga ctgcaggcag    240

aagctgagac ggctaagtca gctacggtga agctatctaa accggtggct ctatggaccc    300

agcaggatgt ctgcaagtgg ttgaagaaac attgtccgaa tcagtatcag atctacagtg    360

agtcattcaa acagcatgac ataactgggc gagccctgct gagacttact gacaaaaagc    420

tcgagcgaat ggggattgcc caggagaacc tccggcagca catcttacaa caggtgctcc    480

agctgaaggt gcgagaagaa gtcagaaatc tacagttact cacacaaggt accctattgc    540

ttcctgatgg gtggatggat ggggagatta gaagaaaggc caccttacta ttaggacaga    600

caggagtcag ggagaatttg ttattgtttc ttcacagaat ttccatcata gaaaatagta    660

tacagattta agattacttc cctttgaaaa cttttctcat agctcactag ggagaaggat    720

gcacaaataa gtaatggatg agcaaacaga attacctgag ctaacttcaa ggtggtcacg    780

tacagttgta tggattgtgt actgcacaac cccagagaat accagtcaca tcaatcaggg    840

tacgattgca ctcactagag ttgtataatg tgcagcctgc acaactgtac agtccagctg    900

tagctatctt cacctgcgcc aattgtgagg gcgctttagc atttgagtga ttcaatagtt    960

acgatgacca gtgatataag tggagttttt gttgtatttt tgttttgctt ttcaccggtt   1020

agtgggagaa aaacatttta gatatgtatt actatacatg aatgtattat acacacacac   1080

tttagagatt gtaagaaccc catttagctt cttgaaagtg gaataatttt tataatagac   1140

tatagtgaat ctaaaactac actgttaaga gtatataatt cttaacagga attataaata   1200

acttcaatat gatgagagca cttaagatct caataactgt ggaagtgaca aaataaagct   1260

agaattcgaa gaaagcctta agttacacta tatgtaactg atatgtctac atgagatttg   1320

gatgctatca accttcattg gctataaact ttgtttgttt tattttagcg tccattgtac   1380

atcgttttaa atgaaaggat gataaaatat gtgtttttga gagccttgag tatttgtcat   1440

tctgcagaat attgtaattg catgcatacc gatattggag aaatctgggt cagccaagtt   1500

tcatgttatt gcatttagat taacctagta atagtccatt tgcctagagg aaataatgtg   1560

ctccctgaaa gatgactatt ctagaaggat aaatatagat ttcaagtgat cgtaaaatag   1620

tattgtttgt ctcatatgca ttatttgcat tttgtcctca gagatttcca atggtgaatt   1680

tactggtata ctaagtgatt taaatttgaa tgtgaaatac tgataggctt ttaagcttct   1740

tttaagaagt agatagaaat acgaagatta tgataagaaa gtctgtcaca gtgctatttg   1800

gaaaacggaa aatttacaag caacctagag gtccagcaat gtgaaaagaa tcaagtaatt   1860

ctgcttaaat tcataagatt cagtataatg cccagttatt aaaattacat ctttaaagaa   1920

tacatgacaa catgggaaat tacgtaagtc atacaaggtg ggaggaaagg tcatgtgtaa   1980

aattgtatgc ataatataag cccaattttg taaaaaccat atattcttat atgtacagaa   2040

aaaaaggact gcaagtaaat atgccaacca ttttaataaa ggatctctct ggattgtggg   2100


<210>  1146
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1146

Met Ala Val Glu Ala Leu His Cys Gly Leu Asn Pro Arg Gly Ile Asp 
1               5                   10                  15      


His Pro Ala His Ala Glu Gly Ile Lys Leu Gln Ile Glu Gly Glu Gly 
            20                  25                  30          


Val Glu Ser Gln Ser Ile Lys Asn Lys Asn Phe Gln Lys Val Pro Asp 
        35                  40                  45              


Gln Lys Gly Thr Pro Lys Arg Leu Gln Ala Glu Ala Glu Thr Ala Lys 
    50                  55                  60                  


Ser Ala Thr Val Lys Leu Ser Lys Pro Val Ala Leu Trp Thr Gln Gln 
65                  70                  75                  80  


Asp Val Cys Lys Trp Leu Lys Lys His Cys Pro Asn Gln Tyr Gln Ile 
                85                  90                  95      


Tyr Ser Glu Ser Phe Lys Gln His Asp Ile Thr Gly Arg Ala Leu Leu 
            100                 105                 110         


Arg Leu Thr Asp Lys Lys Leu Glu Arg Met Gly Ile Ala Gln Glu Asn 
        115                 120                 125             


Leu Arg Gln His Ile Leu Gln Gln Val Leu Gln Leu Lys Val Arg Glu 
    130                 135                 140                 


Glu Val Arg Asn Leu Gln Leu Leu Thr Gln Gly Thr Leu Leu Leu Pro 
145                 150                 155                 160 


Asp Gly Trp Met Asp Gly Glu Ile Arg Arg Lys Ala Thr Leu Leu Leu 
                165                 170                 175     


Gly Gln Thr Gly Val Arg Glu Asn Leu Leu Leu Phe Leu His Arg Ile 
            180                 185                 190         


Ser Ile Ile Glu Asn Ser Ile Gln Ile 
        195                 200     


<210>  1147
<211>  473
<212>  DNA
<213>  Homosapiens

<400>  1147
ctctcttcgg tccgtacctc caagatgaca aagaaaagaa ggaacaacgg tcacaccaaa     60

aagggccgcg gccacgtgca gcctattcgc tgcactaact gtgcccgatg catgcccaag    120

gacaaggcca ttaagaaatt catcattcga aacatagtgg aggccgcagc aatcagggac    180

atttctgaag cgagcgtctt cgatgccaat gagcttccca agctgtatgt gaagctacct    240

tactgtgtga gttgtgcaat tcacagcaaa gtagtcagga atcgatctca tgaagcccgc    300

aaggaccgaa cacccccacc ttgatttaga cctgtgggtg ctgccccacg tcccccacca    360

aagcccatgt aaggagctga gttcttaaag actgaagata gactattctc tggagaaaaa    420

taaaatggaa attgtactta aaaaaaaaaa gcaaacttac acaaaaaaac atg           473


<210>  1148
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  1148

Met Thr Lys Lys Arg Arg Asn Asn Gly His Thr Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Met Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Ile Ile Arg Asn Ile Val Glu Ala Ala 
        35                  40                  45              


Ala Ile Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Asn Glu Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu Pro Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser His Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro 
            


<210>  1149
<211>  3783
<212>  DNA
<213>  Homosapiens

<400>  1149
cccgcgagcg tccatccatc tgtccggccg actgtccagc gaaaggggct ccaggccggg     60

cgcacgtcga cccgggggac cgaggccagg agaggggcca agagcgcggc tgacccttgc    120

gggccggggc aggggacggt ggccgcggcc atgcagtcct gtgccagggc gtgggggctg    180

cgcctgggcc gcggggtcgg gggcggccgc cgcctggctg ggggatcggg gccgtgctgg    240

gcgccgcgga gccgggacag cagcagtggc ggcggggaca gcgccgcggc tggggcctcg    300

cgcctcctgg agcgccttct gcccagacac gacgacttcg ctcggaggca catcggccct    360

ggggacaaag accagagaga gatgctgcag accttggggc tggcgagcat tgatgaattg    420

atcgagaaga cggtccctgc caacatccgt ttgaaaagac ccttgaaaat ggaagaccct    480

gtttgtgaaa atgaaatcct tgcaactctg catgccattt caagcaaaaa ccagatctgg    540

agatcgtata ttggcatggg ctattataac tgctcagtgc cacagacgat tttgcggaac    600

ttactggaga actcaggatg gatcacccag tatactccat accagcctga ggtgtctcag    660

gggaggctgg agagtttact caactaccag accatggtgt gtgacatcac aggcctggac    720

atggccaatg catccctgct ggatgagggg actgcagccg cagaggcact gcagctgtgc    780

tacagacaca acaagaggag gaaatttctc gttgatcccc gttgccaccc acagacaata    840

gctgttgtcc agactcgagc caaatatact ggagtcctca ctgagctgaa gttaccctgt    900

gaaatggact tcagtggaaa agatgtcagt ggagtgttgt tccagtaccc agacacggag    960

gggaaggtgg aagactttac ggaactcgtg gagagagctc atcagagtgg gagcctggcc   1020

tgctgtgcta ctgacctttt agctttgtgc atcttgaggc cacctggaga atttggggta   1080

gacatcgccc tgggcagctc ccagagattt ggagtgccac tgggctatgg gggaccccat   1140

gcagcatttt ttgctgtccg agaaagcttg gtgagaatga tgcctggaag aatggtgggg   1200

gtaacaagag atgccactgg gaaagaagtg tatcgtcttg ctcttcaaac cagggagcaa   1260

cacattcgga gagacaaggc taccagcaac atctgtacag ctcaggccct cttggcgaat   1320

atggctgcca tgtttcgaat ctaccatggt tcccatgggc tggagcatat tgctaggagg   1380

gtacataatg ccactttgat tttgtcagaa ggtctcaagc gagcagggca tcaactccag   1440

catgacctgt tctttgatac cttgaagatt cattgtggct gctcagtgaa ggaggtcttg   1500

ggcagggcgg ctcagcggca gatcaatttt cggctttttg aggatggcac acttggtatt   1560

tctcttgatg aaacagtcaa tgaaaaagat ctggacgatt tgttgtggat ctttggttgt   1620

gagtcatctg cagaactggt tgctgaaagc atgggagagg agtgcagagg tattccaggg   1680

tctgtgttca agaggaccag cccgttcctc acccatcaag tgttcaacag ctaccactct   1740

gaaacaaaca ttgtccggta catgaagaaa ctggaaaata aagacatttc ccttgttcac   1800

agcatgattc cactgggatc ctgcaccatg aaactgaaca gttcgtctga actcgcacct   1860

atcacatgga aagaatttgc aaacatccac ccctttgtgc ctctggatca agctcaagga   1920

tatcagcagc ttttccgaga gcttgagaag gatttgtgtg aactcacagg ttatgaccag   1980

gtctgtttcc agccaaacag cggagcccag ggagaatatg ctggactggc cactatccga   2040

gcctacttaa accagaaagg agaggggcac agaacggttt gcctcattcc gaaatcagca   2100

catgggacca acccagcaag tgcccacatg gcaggcatga agattcagcc tgtggaggtg   2160

gataaatatg ggaatatcga tgcagttcac ctcaaggcca tggtggataa gcacaaggag   2220

aacctagcag ctatcatgat tacataccca tccaccaatg gggtgtttga agagaacatc   2280

agtgacgtgt gtgacctcat ccatcaacat ggaggacagg tctacctaga cggggcaaat   2340

atgaatgctc aggtgggaat ctgtcgccct ggagacttcg ggtctgatgt ctcgcaccta   2400

aatcttcaca agaccttctg cattccccac ggaggaggtg gtcctggcat ggggcccatc   2460

ggagtgaaga aacatctcgc cccgtttttg cccaatcatc ccgtcatttc actaaagcgg   2520

aatgaggatg cctgtcctgt gggaaccgtc agtgcggccc catggggctc cagttccatc   2580

ttgcccattt cctgggctta tatcaagatg atgggaggca agggtcttaa acaagccacg   2640

gaaactgcga tattaaatgc caactacatg gccaagcgat tagaaacaca ctacagaatt   2700

cttttcaggg gtgcaagagg ttatgtgggt catgaattta ttttggacac gagacccttc   2760

aaaaagtctg caaatattga ggctgtggat gtggccaaga gactccagga ttatggattt   2820

cacgccccta ccatgtcctg gcctgtggca gggaccctca tggtggagcc cactgagtcg   2880

gaggacaagg cagagctgga cagattctgt gatgccatga tcagcattcg gcaggaaatt   2940

gctgacattg aggagggccg catcgacccc agggtcaatc cgctgaagat gtctccacac   3000

tccctgacct gcgttacatc ttcccactgg gaccggcctt attccagaga ggtggcagca   3060

ttcccactcc ccttcatgaa accagagaac aaattctggc caacgattgc ccggattgat   3120

gacatatatg gagatcagca cctggtttgt acctgcccac ccatggaagt ttatgagtct   3180

ccattttctg aacaaaagag ggcgtcttct tagtcctctc tccctaagtt taaaggactg   3240

atttgatgcc tctccccaga gcatttgata agcaagaaag atttcatctc ccaccccagc   3300

ctcaagtagg agttttatat actgtgtata tctctgtaat ctctgtcaag gtaaatgtaa   3360

atacagtagc tggagggagt cgaagctgat ggttggaaga cggatttgct ttggtattct   3420

gcttccacat gtgccagttg cctggattgg gagccatttt gtgttttgcg tagaaagttt   3480

taggaacttt aacttttaat gtggcaagtt tgcagatgtc atagaggcta tcctggagac   3540

ttaatagaca tttttttgtt ccaaaagagt ccatgtggac tgtgccatct gtgggaaatc   3600

ccagggcaaa tgtttacatt ttgtataccc tgaagaactc tttttcctct aatatgccta   3660

atctgtaatc acatttctga gtgttttcct ctttttctgt gtgaggtttt tttttttttt   3720

aatctgcatt tattagtatt ctaataaaag cattttgatc ggaaaaaaaa aaaaaaaaaa   3780

aaa                                                                 3783


<210>  1150
<211>  1020
<212>  PRT
<213>  Homosapiens

<400>  1150

Met Gln Ser Cys Ala Arg Ala Trp Gly Leu Arg Leu Gly Arg Gly Val 
1               5                   10                  15      


Gly Gly Gly Arg Arg Leu Ala Gly Gly Ser Gly Pro Cys Trp Ala Pro 
            20                  25                  30          


Arg Ser Arg Asp Ser Ser Ser Gly Gly Gly Asp Ser Ala Ala Ala Gly 
        35                  40                  45              


Ala Ser Arg Leu Leu Glu Arg Leu Leu Pro Arg His Asp Asp Phe Ala 
    50                  55                  60                  


Arg Arg His Ile Gly Pro Gly Asp Lys Asp Gln Arg Glu Met Leu Gln 
65                  70                  75                  80  


Thr Leu Gly Leu Ala Ser Ile Asp Glu Leu Ile Glu Lys Thr Val Pro 
                85                  90                  95      


Ala Asn Ile Arg Leu Lys Arg Pro Leu Lys Met Glu Asp Pro Val Cys 
            100                 105                 110         


Glu Asn Glu Ile Leu Ala Thr Leu His Ala Ile Ser Ser Lys Asn Gln 
        115                 120                 125             


Ile Trp Arg Ser Tyr Ile Gly Met Gly Tyr Tyr Asn Cys Ser Val Pro 
    130                 135                 140                 


Gln Thr Ile Leu Arg Asn Leu Leu Glu Asn Ser Gly Trp Ile Thr Gln 
145                 150                 155                 160 


Tyr Thr Pro Tyr Gln Pro Glu Val Ser Gln Gly Arg Leu Glu Ser Leu 
                165                 170                 175     


Leu Asn Tyr Gln Thr Met Val Cys Asp Ile Thr Gly Leu Asp Met Ala 
            180                 185                 190         


Asn Ala Ser Leu Leu Asp Glu Gly Thr Ala Ala Ala Glu Ala Leu Gln 
        195                 200                 205             


Leu Cys Tyr Arg His Asn Lys Arg Arg Lys Phe Leu Val Asp Pro Arg 
    210                 215                 220                 


Cys His Pro Gln Thr Ile Ala Val Val Gln Thr Arg Ala Lys Tyr Thr 
225                 230                 235                 240 


Gly Val Leu Thr Glu Leu Lys Leu Pro Cys Glu Met Asp Phe Ser Gly 
                245                 250                 255     


Lys Asp Val Ser Gly Val Leu Phe Gln Tyr Pro Asp Thr Glu Gly Lys 
            260                 265                 270         


Val Glu Asp Phe Thr Glu Leu Val Glu Arg Ala His Gln Ser Gly Ser 
        275                 280                 285             


Leu Ala Cys Cys Ala Thr Asp Leu Leu Ala Leu Cys Ile Leu Arg Pro 
    290                 295                 300                 


Pro Gly Glu Phe Gly Val Asp Ile Ala Leu Gly Ser Ser Gln Arg Phe 
305                 310                 315                 320 


Gly Val Pro Leu Gly Tyr Gly Gly Pro His Ala Ala Phe Phe Ala Val 
                325                 330                 335     


Arg Glu Ser Leu Val Arg Met Met Pro Gly Arg Met Val Gly Val Thr 
            340                 345                 350         


Arg Asp Ala Thr Gly Lys Glu Val Tyr Arg Leu Ala Leu Gln Thr Arg 
        355                 360                 365             


Glu Gln His Ile Arg Arg Asp Lys Ala Thr Ser Asn Ile Cys Thr Ala 
    370                 375                 380                 


Gln Ala Leu Leu Ala Asn Met Ala Ala Met Phe Arg Ile Tyr His Gly 
385                 390                 395                 400 


Ser His Gly Leu Glu His Ile Ala Arg Arg Val His Asn Ala Thr Leu 
                405                 410                 415     


Ile Leu Ser Glu Gly Leu Lys Arg Ala Gly His Gln Leu Gln His Asp 
            420                 425                 430         


Leu Phe Phe Asp Thr Leu Lys Ile His Cys Gly Cys Ser Val Lys Glu 
        435                 440                 445             


Val Leu Gly Arg Ala Ala Gln Arg Gln Ile Asn Phe Arg Leu Phe Glu 
    450                 455                 460                 


Asp Gly Thr Leu Gly Ile Ser Leu Asp Glu Thr Val Asn Glu Lys Asp 
465                 470                 475                 480 


Leu Asp Asp Leu Leu Trp Ile Phe Gly Cys Glu Ser Ser Ala Glu Leu 
                485                 490                 495     


Val Ala Glu Ser Met Gly Glu Glu Cys Arg Gly Ile Pro Gly Ser Val 
            500                 505                 510         


Phe Lys Arg Thr Ser Pro Phe Leu Thr His Gln Val Phe Asn Ser Tyr 
        515                 520                 525             


His Ser Glu Thr Asn Ile Val Arg Tyr Met Lys Lys Leu Glu Asn Lys 
    530                 535                 540                 


Asp Ile Ser Leu Val His Ser Met Ile Pro Leu Gly Ser Cys Thr Met 
545                 550                 555                 560 


Lys Leu Asn Ser Ser Ser Glu Leu Ala Pro Ile Thr Trp Lys Glu Phe 
                565                 570                 575     


Ala Asn Ile His Pro Phe Val Pro Leu Asp Gln Ala Gln Gly Tyr Gln 
            580                 585                 590         


Gln Leu Phe Arg Glu Leu Glu Lys Asp Leu Cys Glu Leu Thr Gly Tyr 
        595                 600                 605             


Asp Gln Val Cys Phe Gln Pro Asn Ser Gly Ala Gln Gly Glu Tyr Ala 
    610                 615                 620                 


Gly Leu Ala Thr Ile Arg Ala Tyr Leu Asn Gln Lys Gly Glu Gly His 
625                 630                 635                 640 


Arg Thr Val Cys Leu Ile Pro Lys Ser Ala His Gly Thr Asn Pro Ala 
                645                 650                 655     


Ser Ala His Met Ala Gly Met Lys Ile Gln Pro Val Glu Val Asp Lys 
            660                 665                 670         


Tyr Gly Asn Ile Asp Ala Val His Leu Lys Ala Met Val Asp Lys His 
        675                 680                 685             


Lys Glu Asn Leu Ala Ala Ile Met Ile Thr Tyr Pro Ser Thr Asn Gly 
    690                 695                 700                 


Val Phe Glu Glu Asn Ile Ser Asp Val Cys Asp Leu Ile His Gln His 
705                 710                 715                 720 


Gly Gly Gln Val Tyr Leu Asp Gly Ala Asn Met Asn Ala Gln Val Gly 
                725                 730                 735     


Ile Cys Arg Pro Gly Asp Phe Gly Ser Asp Val Ser His Leu Asn Leu 
            740                 745                 750         


His Lys Thr Phe Cys Ile Pro His Gly Gly Gly Gly Pro Gly Met Gly 
        755                 760                 765             


Pro Ile Gly Val Lys Lys His Leu Ala Pro Phe Leu Pro Asn His Pro 
    770                 775                 780                 


Val Ile Ser Leu Lys Arg Asn Glu Asp Ala Cys Pro Val Gly Thr Val 
785                 790                 795                 800 


Ser Ala Ala Pro Trp Gly Ser Ser Ser Ile Leu Pro Ile Ser Trp Ala 
                805                 810                 815     


Tyr Ile Lys Met Met Gly Gly Lys Gly Leu Lys Gln Ala Thr Glu Thr 
            820                 825                 830         


Ala Ile Leu Asn Ala Asn Tyr Met Ala Lys Arg Leu Glu Thr His Tyr 
        835                 840                 845             


Arg Ile Leu Phe Arg Gly Ala Arg Gly Tyr Val Gly His Glu Phe Ile 
    850                 855                 860                 


Leu Asp Thr Arg Pro Phe Lys Lys Ser Ala Asn Ile Glu Ala Val Asp 
865                 870                 875                 880 


Val Ala Lys Arg Leu Gln Asp Tyr Gly Phe His Ala Pro Thr Met Ser 
                885                 890                 895     


Trp Pro Val Ala Gly Thr Leu Met Val Glu Pro Thr Glu Ser Glu Asp 
            900                 905                 910         


Lys Ala Glu Leu Asp Arg Phe Cys Asp Ala Met Ile Ser Ile Arg Gln 
        915                 920                 925             


Glu Ile Ala Asp Ile Glu Glu Gly Arg Ile Asp Pro Arg Val Asn Pro 
    930                 935                 940                 


Leu Lys Met Ser Pro His Ser Leu Thr Cys Val Thr Ser Ser His Trp 
945                 950                 955                 960 


Asp Arg Pro Tyr Ser Arg Glu Val Ala Ala Phe Pro Leu Pro Phe Met 
                965                 970                 975     


Lys Pro Glu Asn Lys Phe Trp Pro Thr Ile Ala Arg Ile Asp Asp Ile 
            980                 985                 990         


Tyr Gly Asp Gln His Leu Val Cys  Thr Cys Pro Pro Met  Glu Val Tyr 
        995                 1000                 1005             


Glu Ser  Pro Phe Ser Glu Gln  Lys Arg Ala Ser Ser  
    1010                 1015                 1020 


<210>  1151
<211>  4239
<212>  DNA
<213>  Homosapiens

<400>  1151
aattcggcac gagaacagct gtcacctagt gcggaacaag tctcccaaat ttcccaaatc     60

tccctgggcc ggaggccact gtcttctctt cctcctccac cgagtcgtgc tctcgcccca    120

acccgcgcgc cagacactgc cctaaccatc atggaggtgg ccgaggtgga aagtcctctg    180

aaccccagct gtaagataat gaccttcaga ccctccatgg aggagttccg ggagttcaac    240

aaataccttg catacatgga gtctaaagga gcccatcgtg cgggtcttgc aaaggtgatt    300

cctcctaagg agtggaagcc aagacagtgc tatgatgaca ttgataattt gctcattcca    360

gcaccaattc agcagatggt cacagggcag tcaggactgt tcactcagta caacatccag    420

aaaaaagcga tgactgtgaa ggagttcagg cagctggcca acagtggcaa atattgtact    480

ccaagatact tggattacga agatttggag cgcaagtact ggaagaactt aacttttgtg    540

gcacctatct atggtgcaga tattaatggg agcatatatg atgagggtgt ggatgaatgg    600

aacatagctc gcatcaatac agtcttggat gtggttgaag aagagtgtgg catttctatt    660

gagggtgtaa ataccccata tctctatttt ggcatgtgga agaccacgtt tgcatggcac    720

accgaagaca tggacctcta tagcattaat tatctccact ttggagagcc caagtcttgg    780

tatgctatac ctccggagca tggaaaacga cttgaaagac tagctcaagg ttttttccca    840

agcagctccc aagggtgtga tgcatttctt cgccacaaga tgacattgat ttctccatca    900

gtattgaaga aatatggtat tccctttgac aagataaccc aggaggctgg agaattcatg    960

atcactttcc catatggcta ccatgctggt tttaatcatg gtttcaactg tgcagaatct   1020

acaaattttg ctactgtcag atggattgac tatggaaaag ttgccaaatt gtgcacttgc   1080

aggaaagaca tggtgaagat ttcaatggat atctttgtga ggaaatttca gccagacaga   1140

tatcagcttt ggaaacaagg aaaggatata tacaccattg atcacacgaa gcctactcca   1200

gcatccaccc ctgaagtaaa agcatggctg cagaggagga ggaaagtaag aaaagcatcc   1260

cgaagcttcc agtgtgctag gtctacctct aaaaggccta aggctgatga ggaagaggaa   1320

gtgtcagatg aagtcgatgg ggcagaggtc cctaaccccg actcagtcac agatgacctc   1380

aaggtcagtg aaaagtcaga agcagcagtg aagctgagga acacagaagc atcttcagaa   1440

gaagagtcat ctgctagcag gatgcaggtg gagcagaatt tatcagatca tatcaaactc   1500

tcaggaaaca gctgcttaag tacatctgta acagaagaca taaaaactga ggatgacaaa   1560

gcttatgcat atagaagtgt accttctata tccagtgagg ctgatgattc cattccattg   1620

tctactggct atgagaagcc cgagaaatca gacccatccg agctttcatg gccaaagtca   1680

cctgagtcat gctcatcagt ggcagagagt aatggtgtgt taacagaggg agaagagagt   1740

gatgtggaga gccatgggaa tggccttgaa cctggggaaa tcccagcggt ccccagtgga   1800

gagagaaata gcttcaaagt ccccagtata gcagagggag agaacaaaac ctctaagagt   1860

tggcgccatc cacttagcag gcctccagca agatctccga tgactcttgt gaagcagcag   1920

gcgccaagtg atgaagaatt gcctgaggtt ctgtccattg aggaggaagt ggaagaaaca   1980

gagtcttggg cgaaacctct catccacctt tggcagacga agtcccctaa cttcgcagct   2040

gagcaagagt ataatgcaac agtggccagg atgaagccac actgtgccat ctgcactctg   2100

ctcatgccgt accacaagcc agatagcagc aatgaagaaa atgatgctag atgggagaca   2160

aaattagatg aagtcgttac atcggaggga aagactaagc ccctcatacc agagatgtgt   2220

tttatttata gtgaagaaaa tatagaatat tctccaccca atgccttcct tgaagaggat   2280

ggaacaagtc tccttatttc ctgtgcaaag tgctgcgtac gggttcatgc aagttgttat   2340

ggtattcctt ctcatgagat ctgtgatgga tggctgtgtg cccggtgcaa aagaaatgcg   2400

tggacagcag aatgctgtct ctgcaatttg agaggaggtg ctcttaagca aacgaagaac   2460

aataggtggg cccatgtcat gtgcgccgtt gcggtcccag aagttcgatt cactaatgtc   2520

ccagaaagga cacaaataga tgtaggcaga atacctttac agaggttaaa attgaaatgc   2580

atcttctgca gacaccgggt taagagggtc tctggagcct gcatccagtg ttcctacggt   2640

cgctgcccgg cctccttcca tgtcacttgt gcccatgctg ctggggtact gatggagcct   2700

gatgattggc cttatgtggt gaacattaca tgctttcgac ataaggtcaa ccccaacgtg   2760

aagtccaagg cttgcgagaa ggtcatttcc gtgggtcaaa cggtcatcac gaagcatcgg   2820

aacacccggt attacagttg cagagtgatg gctgtgacat cgcagacctt ctatgaggtc   2880

atgtttgatg atggctcctt tagcagagac acatttcctg aggatatcgt gagccgagac   2940

tgtctgaagc tgggcccacc tgctgaggga gaagtcgtcc aagtcaagtg gcccgatggc   3000

aaactctatg gagcaaaata ttttggatca aatattgccc acatgtacca ggttgagttt   3060

gaagatggat cccagatagc aatgaagaga gaggacatct acactttaga tgaagagtta   3120

cccaagagag tgaaagctcg attttccaca gcctctgaca tgcgatttga agacacgttt   3180

tatggagcag acattatcca aggggagaga aagagacaaa gagtgctgag ctccaggttt   3240

aagaatgaat atgtggccga ccctgtatac cgcacttttt tgaagagctc tttccagaag   3300

aagtgccaga agagacagta gtctgcatac atcgctgcag gccacagagc agcttgggtt   3360

ggaaaagaga agatgaaggg acatccttgg ggctgtgccg tgagatttgc tggcataggt   3420

gacagggtgt gtctctgaca gtggtaaatc gggtttccag agtttggtca ccaaaaatac   3480

aaaatacaca caatgaattg gacgcagcaa tctgaaatca tctctagtct tgctttcact   3540

tgtgagcagt tgtcttctat gatcccaaag aagttttcta agtgaaagga aatactagtg   3600

aatcacccac aaggaaaagc cactgccaca gaggaggcgg gtccccttgt gcggcttagg   3660

gccctgtcag gaaacacacg gggacctctc tctctagctc cagcaggtgg cacctcggta   3720

cccagcgggt agggcgataa tttatatatt ttccacagtc agggaaggac tctcacttat   3780

ttgtttcaaa ttgcagtttt tataaaacat ttttaaaaca caaatggcat gtatgctaat   3840

gagatttacc cgtgtgctat ctgtatttcc cttgtacaga acttttacat ttttgaatat   3900

tcctattact tttgattgtg tctgatggga actgagttgt tggcctttgt gaaatgaaat   3960

ttttggctct tgagaaagaa ttcttatgaa ttgttatgcg aattttatat atttaaagag   4020

ggagatctgg ggctgttatt tttaaacact ttttttcata atacatattc cgagtagata   4080

tttataaaat atatgtttct ttcattatgt gtttgtaaaa ttagagttta aataaatatg   4140

ctttgatgca tagttttgaa ctaatgtaac atgatttttc ttttttaaaa cagcctgaaa   4200

atgtactagt gtttaaaaat aaagatttcc attttctcc                          4239


<210>  1152
<211>  1056
<212>  PRT
<213>  Homosapiens

<400>  1152

Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile 
1               5                   10                  15      


Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr 
            20                  25                  30          


Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys 
        35                  40                  45              


Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile 
    50                  55                  60                  


Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln 
65                  70                  75                  80  


Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val 
                85                  90                  95      


Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg 
            100                 105                 110         


Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr 
        115                 120                 125             


Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp 
    130                 135                 140                 


Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Ile Asn Thr Val Leu Asp 
145                 150                 155                 160 


Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro 
                165                 170                 175     


Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu 
            180                 185                 190         


Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys 
        195                 200                 205             


Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu 
    210                 215                 220                 


Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu 
225                 230                 235                 240 


Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly 
                245                 250                 255     


Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr 
            260                 265                 270         


Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala 
        275                 280                 285             


Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val 
    290                 295                 300                 


Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp 
305                 310                 315                 320 


Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln 
                325                 330                 335     


Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser 
            340                 345                 350         


Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys 
        355                 360                 365             


Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val 
385                 390                 395                 400 


Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser 
                405                 410                 415     


Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu 
            420                 425                 430         


Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile 
        435                 440                 445             


Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile 
    450                 455                 460                 


Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile 
465                 470                 475                 480 


Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Thr Gly Tyr Glu Lys 
                485                 490                 495     


Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu 
            500                 505                 510         


Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu 
        515                 520                 525             


Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile 
    530                 535                 540                 


Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile 
545                 550                 555                 560 


Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser 
                565                 570                 575     


Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro 
            580                 585                 590         


Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu 
        595                 600                 605             


Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys 
    610                 615                 620                 


Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg 
625                 630                 635                 640 


Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys 
                645                 650                 655     


Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu 
            660                 665                 670         


Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu 
        675                 680                 685             


Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn 
    690                 695                 700                 


Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys 
705                 710                 715                 720 


Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu 
                725                 730                 735     


Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr 
            740                 745                 750         


Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr 
        755                 760                 765             


Lys Asn Asn Arg Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu 
    770                 775                 780                 


Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg 
785                 790                 795                 800 


Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile Phe Cys Arg His Arg 
                805                 810                 815     


Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys Ser Tyr Gly Arg Cys 
            820                 825                 830         


Pro Ala Ser Phe His Val Thr Cys Ala His Ala Ala Gly Val Leu Met 
        835                 840                 845             


Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile Thr Cys Phe Arg His 
    850                 855                 860                 


Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys Glu Lys Val Ile Ser 
865                 870                 875                 880 


Val Gly Gln Thr Val Ile Thr Lys His Arg Asn Thr Arg Tyr Tyr Ser 
                885                 890                 895     


Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe Tyr Glu Val Met Phe 
            900                 905                 910         


Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro Glu Asp Ile Val Ser 
        915                 920                 925             


Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu Gly Glu Val Val Gln 
    930                 935                 940                 


Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala Lys Tyr Phe Gly Ser 
945                 950                 955                 960 


Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln Ile 
                965                 970                 975     


Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp Glu Glu Leu Pro Lys 
            980                 985                 990         


Arg Val Lys Ala Arg Phe Ser Thr  Ala Ser Asp Met Arg  Phe Glu Asp 
        995                 1000                 1005             


Thr Phe  Tyr Gly Ala Asp Ile  Ile Gln Gly Glu Arg  Lys Arg Gln 
    1010                 1015                 1020             


Arg Val  Leu Ser Ser Arg Phe  Lys Asn Glu Tyr Val  Ala Asp Pro 
    1025                 1030                 1035             


Val Tyr  Arg Thr Phe Leu Lys  Ser Ser Phe Gln Lys  Lys Cys Gln 
    1040                 1045                 1050             


Lys Arg  Gln 
    1055     


<210>  1153
<211>  2016
<212>  DNA
<213>  Homosapiens

<400>  1153
atgagtgtga gctcgtgagt gggcgccgcc gccaccgccc ccgccgccgt cgtctcggta     60

gcagccttcg ccacgccggg gtcttcagct ccactggggc catgtcagag cgagaagagc    120

ggcggtttgt ggagatccct cgggagtctg tccggctcat ggcggagagc acgggcctgg    180

agctgagcga tgaggtggcg gcgctgctcg cagaggacgt gtgctatcgt ctgagagagg    240

ccacgcagaa tagctctcag ttcatgaagc acaccaaacg ccggaagctg acggttgagg    300

acttcaacag ggccctcaga tggagcagcg tggaggctgt gtgtggttac ggatcacagg    360

aggcactgcc catgcgcccc gccagggagg gtgaactcta ctttcctgag gatcgagagg    420

tgaacctggt ggagctggcc ctggctacca acatccccaa aggctgtgct gagacagctg    480

tcagagttca tgtctcctac ctggatggca aagggaacct ggcacctcaa ggatcggtgc    540

ccagtgctgt gtcttcactg acagatgacc ttctcaagta ctatcaccag gtgactcgtg    600

ctgtgctagg ggatgatccg caactgatga aggttgcact ccaggacttg cagacgaact    660

ccaagattgg ggcactcctg ccttactttg tttatgtggt cagtggggtg aaatctgtaa    720

gccatgacct ggagcaactg caccggctgc tgcaggtggc acggagccta tttcgtaatc    780

cgcacctgtg cttggggccc tatgtccgct gtctggtggg cagtgtcctc tactgtgtcc    840

tggagccact ggctgcctcc atcaaccccc tgaatgacca ctggactctg cgggatgggg    900

ctgccctcct gctcagccac atcttctgga ctcatgggga ccttgtaagt ggcctctatc    960

agcatatcct gctatccctg cagaagatcc tggcagatcc tgtgcggccg ctctgctgcc   1020

actatggagc cgtggtgggg ctgcatgctc ttggctggaa ggcagtagaa cgagtcctgt   1080

acccacacct gtccacctac tggacaaact tgcaggctgt gctggatgat tattcagtat   1140

ctaatgccca ggtcaaagca gatggacaca aagtctatgg agccattctg gtggcggtag   1200

agcgactgct gaagatgaag gcccaggcag cagagcccaa caggggtggc ccaggtggca   1260

gggggtgccg gcgcctggac gacctgccat gggacagcct tctctttcaa gagtcgtcct   1320

ccgggggcgg tgcagaaccc agctttgggt ccggcctccc gctgccgcca gggggcgcgg   1380

ggccggagga cccttctctt tcggtgaccc tggccgacat ctaccgggag ctctacgcct   1440

tcttcggtga cagcttggcc acacgctttg gcaccggcca gcctgcaccc acggctccgc   1500

ggccgcccgg ggacaagaag gagccggcgg cagccccgga ctcggtgcgg aagatgccgc   1560

agctgacggc aagcgccata gtcagcccgc acggcgacga gagcccccgg ggcagcggcg   1620

gaggcggccc cgcgtcggcc tctgggcccg ccgcctctga gagcaggccc ttgccgcgcg   1680

tgcatcgggc gcgcggggca ccccggcagc agggccccgg gaccggcacc cgcgacgttt   1740

tccagaagag ccgtttcgcc ccgcgcggcg ccccgcactt tcgtttcatc atagccgggc   1800

ggcaggctgg gaggcgctgc cgcgggcgcc ttttccagac tgccttcccc gcgccgtacg   1860

ggcctagccc ggcctcgcgc tacgtgcaga aactgcccat gatcggccgt accagccgcc   1920

ccgcccgccg gtgggcgctc tcggactact cgctgtactt gccgctctga gtcagtggcc   1980

ccttcgttcc ttgtaaataa atcccgcccc cggaaa                             2016


<210>  1154
<211>  622
<212>  PRT
<213>  Homosapiens

<400>  1154

Met Ser Glu Arg Glu Glu Arg Arg Phe Val Glu Ile Pro Arg Glu Ser 
1               5                   10                  15      


Val Arg Leu Met Ala Glu Ser Thr Gly Leu Glu Leu Ser Asp Glu Val 
            20                  25                  30          


Ala Ala Leu Leu Ala Glu Asp Val Cys Tyr Arg Leu Arg Glu Ala Thr 
        35                  40                  45              


Gln Asn Ser Ser Gln Phe Met Lys His Thr Lys Arg Arg Lys Leu Thr 
    50                  55                  60                  


Val Glu Asp Phe Asn Arg Ala Leu Arg Trp Ser Ser Val Glu Ala Val 
65                  70                  75                  80  


Cys Gly Tyr Gly Ser Gln Glu Ala Leu Pro Met Arg Pro Ala Arg Glu 
                85                  90                  95      


Gly Glu Leu Tyr Phe Pro Glu Asp Arg Glu Val Asn Leu Val Glu Leu 
            100                 105                 110         


Ala Leu Ala Thr Asn Ile Pro Lys Gly Cys Ala Glu Thr Ala Val Arg 
        115                 120                 125             


Val His Val Ser Tyr Leu Asp Gly Lys Gly Asn Leu Ala Pro Gln Gly 
    130                 135                 140                 


Ser Val Pro Ser Ala Val Ser Ser Leu Thr Asp Asp Leu Leu Lys Tyr 
145                 150                 155                 160 


Tyr His Gln Val Thr Arg Ala Val Leu Gly Asp Asp Pro Gln Leu Met 
                165                 170                 175     


Lys Val Ala Leu Gln Asp Leu Gln Thr Asn Ser Lys Ile Gly Ala Leu 
            180                 185                 190         


Leu Pro Tyr Phe Val Tyr Val Val Ser Gly Val Lys Ser Val Ser His 
        195                 200                 205             


Asp Leu Glu Gln Leu His Arg Leu Leu Gln Val Ala Arg Ser Leu Phe 
    210                 215                 220                 


Arg Asn Pro His Leu Cys Leu Gly Pro Tyr Val Arg Cys Leu Val Gly 
225                 230                 235                 240 


Ser Val Leu Tyr Cys Val Leu Glu Pro Leu Ala Ala Ser Ile Asn Pro 
                245                 250                 255     


Leu Asn Asp His Trp Thr Leu Arg Asp Gly Ala Ala Leu Leu Leu Ser 
            260                 265                 270         


His Ile Phe Trp Thr His Gly Asp Leu Val Ser Gly Leu Tyr Gln His 
        275                 280                 285             


Ile Leu Leu Ser Leu Gln Lys Ile Leu Ala Asp Pro Val Arg Pro Leu 
    290                 295                 300                 


Cys Cys His Tyr Gly Ala Val Val Gly Leu His Ala Leu Gly Trp Lys 
305                 310                 315                 320 


Ala Val Glu Arg Val Leu Tyr Pro His Leu Ser Thr Tyr Trp Thr Asn 
                325                 330                 335     


Leu Gln Ala Val Leu Asp Asp Tyr Ser Val Ser Asn Ala Gln Val Lys 
            340                 345                 350         


Ala Asp Gly His Lys Val Tyr Gly Ala Ile Leu Val Ala Val Glu Arg 
        355                 360                 365             


Leu Leu Lys Met Lys Ala Gln Ala Ala Glu Pro Asn Arg Gly Gly Pro 
    370                 375                 380                 


Gly Gly Arg Gly Cys Arg Arg Leu Asp Asp Leu Pro Trp Asp Ser Leu 
385                 390                 395                 400 


Leu Phe Gln Glu Ser Ser Ser Gly Gly Gly Ala Glu Pro Ser Phe Gly 
                405                 410                 415     


Ser Gly Leu Pro Leu Pro Pro Gly Gly Ala Gly Pro Glu Asp Pro Ser 
            420                 425                 430         


Leu Ser Val Thr Leu Ala Asp Ile Tyr Arg Glu Leu Tyr Ala Phe Phe 
        435                 440                 445             


Gly Asp Ser Leu Ala Thr Arg Phe Gly Thr Gly Gln Pro Ala Pro Thr 
    450                 455                 460                 


Ala Pro Arg Pro Pro Gly Asp Lys Lys Glu Pro Ala Ala Ala Pro Asp 
465                 470                 475                 480 


Ser Val Arg Lys Met Pro Gln Leu Thr Ala Ser Ala Ile Val Ser Pro 
                485                 490                 495     


His Gly Asp Glu Ser Pro Arg Gly Ser Gly Gly Gly Gly Pro Ala Ser 
            500                 505                 510         


Ala Ser Gly Pro Ala Ala Ser Glu Ser Arg Pro Leu Pro Arg Val His 
        515                 520                 525             


Arg Ala Arg Gly Ala Pro Arg Gln Gln Gly Pro Gly Thr Gly Thr Arg 
    530                 535                 540                 


Asp Val Phe Gln Lys Ser Arg Phe Ala Pro Arg Gly Ala Pro His Phe 
545                 550                 555                 560 


Arg Phe Ile Ile Ala Gly Arg Gln Ala Gly Arg Arg Cys Arg Gly Arg 
                565                 570                 575     


Leu Phe Gln Thr Ala Phe Pro Ala Pro Tyr Gly Pro Ser Pro Ala Ser 
            580                 585                 590         


Arg Tyr Val Gln Lys Leu Pro Met Ile Gly Arg Thr Ser Arg Pro Ala 
        595                 600                 605             


Arg Arg Trp Ala Leu Ser Asp Tyr Ser Leu Tyr Leu Pro Leu 
    610                 615                 620         


<210>  1155
<211>  881
<212>  DNA
<213>  Homosapiens

<400>  1155
gcgccatggc gctgtcctgg ctgcagcgcg tcgagcttgc gctctttgct gccgccttcc     60

tgtgcggggc cgtggcggcc gcggcgatga ctcggaccca gggctccttc agtggtagat    120

gtcccctgta tggtgtggcc accctgaatg gctcctccct ggccttatcc cgtccctcag    180

caccatccct gtgctacttt gtagctgggg cctctggcct cttggccctc tactgcctcc    240

tgcttttgct cttctggatc tacagcagct gcatcgagga ctcccacaga ggtgctatag    300

ggctgcgcat tgcactggcc atctcagcta tagccgtctt cctggtcttg gtgtctgcct    360

gtatccttcg atttggcacc aggtctctct gcaactccat catctccttg aacactacaa    420

ttagctgttc tgaagcccag aaaattccat ggacaccccc tggaactgct ctgcagtttt    480

actccaacct acacaatgct gaaacctctt cttgggtgaa tttggtattg tggtgtgtgg    540

tcttggtgct ccaggtcgtg cagtggaagt ctgaagccac cccataccgg cctctggaga    600

ggggtgaccc tgagtggagc tctgagacag atgctctcgt tgggtcacgc ctttcccatt    660

cctgaagaat aagcggagtg cttcctgcag ccgaagactc catgcccaag tgcctgtaat    720

cccccccctc aaggccctgt ttatgttggg agtcttagtt ttcctttcgt tggggggtgg    780

gggggaaaca taatgacagg cccccctcca cctcttcctg cagctgtttt tgtaccaaaa    840

tattatatta ctgtcttcat cttaaaaaaa aaaaaaaaaa a                        881


<210>  1156
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  1156

Met Ala Leu Ser Trp Leu Gln Arg Val Glu Leu Ala Leu Phe Ala Ala 
1               5                   10                  15      


Ala Phe Leu Cys Gly Ala Val Ala Ala Ala Ala Met Thr Arg Thr Gln 
            20                  25                  30          


Gly Ser Phe Ser Gly Arg Cys Pro Leu Tyr Gly Val Ala Thr Leu Asn 
        35                  40                  45              


Gly Ser Ser Leu Ala Leu Ser Arg Pro Ser Ala Pro Ser Leu Cys Tyr 
    50                  55                  60                  


Phe Val Ala Gly Ala Ser Gly Leu Leu Ala Leu Tyr Cys Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Trp Ile Tyr Ser Ser Cys Ile Glu Asp Ser His Arg Gly 
                85                  90                  95      


Ala Ile Gly Leu Arg Ile Ala Leu Ala Ile Ser Ala Ile Ala Val Phe 
            100                 105                 110         


Leu Val Leu Val Ser Ala Cys Ile Leu Arg Phe Gly Thr Arg Ser Leu 
        115                 120                 125             


Cys Asn Ser Ile Ile Ser Leu Asn Thr Thr Ile Ser Cys Ser Glu Ala 
    130                 135                 140                 


Gln Lys Ile Pro Trp Thr Pro Pro Gly Thr Ala Leu Gln Phe Tyr Ser 
145                 150                 155                 160 


Asn Leu His Asn Ala Glu Thr Ser Ser Trp Val Asn Leu Val Leu Trp 
                165                 170                 175     


Cys Val Val Leu Val Leu Gln Val Val Gln Trp Lys Ser Glu Ala Thr 
            180                 185                 190         


Pro Tyr Arg Pro Leu Glu Arg Gly Asp Pro Glu Trp Ser Ser Glu Thr 
        195                 200                 205             


Asp Ala Leu Val Gly Ser Arg Leu Ser His Ser 
    210                 215                 


<210>  1157
<211>  839
<212>  DNA
<213>  Homosapiens

<400>  1157
atgttgtatt tcgtgttctg cgtgctggat tggaagcccc accccggaag tcggctggcc     60

atggcggcgc cttggaggcg atggcccacg gggctgctag ccgtgctgcg gcccctgctc    120

acctgccggc ccctgcaagg cacgacgctg caacgggatg tgctgctctt tgagcatgat    180

cggggccgct tcttcaccat cctcgggctg ttctgcgcgg gccagggcgt cttctgggct    240

tccatggctg tggcagccgt gtcccggccc ccggttccgg tgcagcctct ggatgcggag    300

gtcccaaatc gtggcccctt cgacctgcgc tccgcgctct ggcgctacgg tctggccgtc    360

ggctgcggcg ccatcggagc cctcgtactc ggtgctggtc ttctcttctc tctccggtct    420

gtgcgctcag tggtgcttcg agctggaggg cagcaggtga ccctcaccac tcatgccccc    480

tttggcttgg gggcccattt cacagttcct ttgaagcagg tatcttgcat ggcccaccgg    540

ggtgaagtcc ctgccatgct acctctgaaa gtcaaaggcc gacgcttcta tttcctcttg    600

gacaaaactg gacacttccc taacacaaaa ctctttgaca atactgtggg tgcctaccgg    660

agcttgtgaa gaaatgacct caagtcactc acctctccaa gaggaggata aaaactgaac    720

cttggggagc caggtgtgtt ggttcacacc tgttgtaatc ccagcacttt gggagggtga    780

ggcaggagca ctgctcgagc ccaggctggg caacatagcg agaccttgtc tctatttac     839


<210>  1158
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  1158

Met Leu Tyr Phe Val Phe Cys Val Leu Asp Trp Lys Pro His Pro Gly 
1               5                   10                  15      


Ser Arg Leu Ala Met Ala Ala Pro Trp Arg Arg Trp Pro Thr Gly Leu 
            20                  25                  30          


Leu Ala Val Leu Arg Pro Leu Leu Thr Cys Arg Pro Leu Gln Gly Thr 
        35                  40                  45              


Thr Leu Gln Arg Asp Val Leu Leu Phe Glu His Asp Arg Gly Arg Phe 
    50                  55                  60                  


Phe Thr Ile Leu Gly Leu Phe Cys Ala Gly Gln Gly Val Phe Trp Ala 
65                  70                  75                  80  


Ser Met Ala Val Ala Ala Val Ser Arg Pro Pro Val Pro Val Gln Pro 
                85                  90                  95      


Leu Asp Ala Glu Val Pro Asn Arg Gly Pro Phe Asp Leu Arg Ser Ala 
            100                 105                 110         


Leu Trp Arg Tyr Gly Leu Ala Val Gly Cys Gly Ala Ile Gly Ala Leu 
        115                 120                 125             


Val Leu Gly Ala Gly Leu Leu Phe Ser Leu Arg Ser Val Arg Ser Val 
    130                 135                 140                 


Val Leu Arg Ala Gly Gly Gln Gln Val Thr Leu Thr Thr His Ala Pro 
145                 150                 155                 160 


Phe Gly Leu Gly Ala His Phe Thr Val Pro Leu Lys Gln Val Ser Cys 
                165                 170                 175     


Met Ala His Arg Gly Glu Val Pro Ala Met Leu Pro Leu Lys Val Lys 
            180                 185                 190         


Gly Arg Arg Phe Tyr Phe Leu Leu Asp Lys Thr Gly His Phe Pro Asn 
        195                 200                 205             


Thr Lys Leu Phe Asp Asn Thr Val Gly Ala Tyr Arg Ser Leu 
    210                 215                 220         


<210>  1159
<211>  2307
<212>  DNA
<213>  Homosapiens

<400>  1159
gtgctttgct gtataaatgc ggtggcgccc ggcgtaggga cacttcggtc ctgagcgctt     60

gggagttagg ttgtttgccg gcgtagcggc cagcgcctga gcccgccctt gatcttcgct    120

gtggcatggc ggacgagggg aagtcgtaca gcgaacacga tgatgaacgc gttaatttcc    180

ctcaaagaaa gaagaaaggc cggggtccct tccggtggaa atatggtgaa ggaaaccgta    240

ggtctggaag aggcggttct ggtattcggt cttcccgcct tgaggaagat gatggagatg    300

tggcaatgag tgatgcccag gatggtcccc gagtacgata caacccctat accacccgac    360

ctaaccgtcg gggtgatact tggcatgatc gagatcgcat tcatgttact gtgcggagag    420

acagagctcc tccagagaga ggaggggctg gcaccagcca ggatgggacc tcaaagaact    480

ggttcaagat tacaattcct tatggcagaa agtatgacaa ggcatggctc ctgagcatga    540

ttcagagcaa gtgcagtgtg cccttcaccc ctattgagtt tcactatgag aatacacggg    600

cccagttctt cgttgaagac gccagtactg cctctgcatt gaaggctgtc aactataaga    660

ttttggatcg ggagaaccga aggatatcta tcatcatcaa ctcttctgct ccaccccaca    720

ctatactgaa tgaactgaag ccagaacaag tagaacagct aaagctgatc atgagcaaac    780

gatacgatgg ctcccaacaa gcccttgacc tcaaaggcct ccgttcagac ccagatttgg    840

tggcccagaa cattgacgtt gtcctgaatc gcagaagctg tatggcagct accctgagga    900

tcattgaaga gaacatccct gagctattgt ccttgaactt gagcaacaac aggctgtaca    960

ggctggatga catgtctagc attgttcaga aggcacccaa cctgaagatc ctaaaccttt   1020

ctggaaatga attgaagtct gagcgggaat tggacaagat aaaggggctg aagctagaag   1080

agctctggct cgatggaaac tccctgtgtg acaccttccg agaccagtcc acctacatca   1140

gcgccattcg cgaacgattt cccaagttac tacgcctgga tggccatgag ctacccccac   1200

caattgcctt tgatgttgaa gcccccacga cgttaccgcc ctgcaaggga agctattttg   1260

gaacagaaaa cttgaagagt ctggtcttgc acttcctgca acagtactat gcaatttacg   1320

actctggaga ccgacaaggg ctcctggatg cctaccatga tggggcctgc tgttccctga   1380

gcattccttt cattcctcag aaccctgccc gaagcagctt agccgagtat ttcaaggata   1440

gcagaaatgt gaagaagctt aaagacccta ccttgcggtt ccggctgctg aagcacacgc   1500

gtctcaacgt tgttgccttc ctcaatgagt tgcccaaaac ccagcacgac gtcaattcct   1560

tcgtggtaga cataagcgcc cagacaagca cattgctgtg tttttctgtc aatggagtct   1620

tcaaggaagt ggacggaaag tcccgggatt ctttgcgagc cttcacccgg acattcattg   1680

ctgttcctgc tagcaattca gggctatgta ttgtaaatga tgagctattt gtgcggaatg   1740

ccagttctga agagatccaa agagccttcg ctatgcctgc acccacgcct tcctccagcc   1800

cggtgcccac cctctctcca gagcagcagg aaatgttgca agcattctct acccagtctg   1860

gcatgaacct cgagtggtcc cagaagtgcc ttcaggacaa caactgggac tacaccagat   1920

ctgcccaggc cttcactcat ctcaaggcca agggcgagat cccagaagtg gcattcatga   1980

agtgatcgta gtcatgcctc agaagcagtc ccccctgtaa atagtccttg gatattaccg   2040

tctggttgtc gtctgtcatc tcctcctgtc tggcccgagg ccgccccgtg actgtgaccg   2100

agggagggag ggctgcctga tccctctcct cgcctgcctt ctggaagact tcagaagatt   2160

gagcctcact ggtgccagga agccaaagct tactttgtag aactgacact aaactacccg   2220

aaggacttag gtgctttgtg tacttaaccc caggacctcc ttacttttta atataaagag   2280

tgatgttgta aaaaaaaaaa aaaaaaa                                       2307


<210>  1160
<211>  619
<212>  PRT
<213>  Homosapiens

<400>  1160

Met Ala Asp Glu Gly Lys Ser Tyr Ser Glu His Asp Asp Glu Arg Val 
1               5                   10                  15      


Asn Phe Pro Gln Arg Lys Lys Lys Gly Arg Gly Pro Phe Arg Trp Lys 
            20                  25                  30          


Tyr Gly Glu Gly Asn Arg Arg Ser Gly Arg Gly Gly Ser Gly Ile Arg 
        35                  40                  45              


Ser Ser Arg Leu Glu Glu Asp Asp Gly Asp Val Ala Met Ser Asp Ala 
    50                  55                  60                  


Gln Asp Gly Pro Arg Val Arg Tyr Asn Pro Tyr Thr Thr Arg Pro Asn 
65                  70                  75                  80  


Arg Arg Gly Asp Thr Trp His Asp Arg Asp Arg Ile His Val Thr Val 
                85                  90                  95      


Arg Arg Asp Arg Ala Pro Pro Glu Arg Gly Gly Ala Gly Thr Ser Gln 
            100                 105                 110         


Asp Gly Thr Ser Lys Asn Trp Phe Lys Ile Thr Ile Pro Tyr Gly Arg 
        115                 120                 125             


Lys Tyr Asp Lys Ala Trp Leu Leu Ser Met Ile Gln Ser Lys Cys Ser 
    130                 135                 140                 


Val Pro Phe Thr Pro Ile Glu Phe His Tyr Glu Asn Thr Arg Ala Gln 
145                 150                 155                 160 


Phe Phe Val Glu Asp Ala Ser Thr Ala Ser Ala Leu Lys Ala Val Asn 
                165                 170                 175     


Tyr Lys Ile Leu Asp Arg Glu Asn Arg Arg Ile Ser Ile Ile Ile Asn 
            180                 185                 190         


Ser Ser Ala Pro Pro His Thr Ile Leu Asn Glu Leu Lys Pro Glu Gln 
        195                 200                 205             


Val Glu Gln Leu Lys Leu Ile Met Ser Lys Arg Tyr Asp Gly Ser Gln 
    210                 215                 220                 


Gln Ala Leu Asp Leu Lys Gly Leu Arg Ser Asp Pro Asp Leu Val Ala 
225                 230                 235                 240 


Gln Asn Ile Asp Val Val Leu Asn Arg Arg Ser Cys Met Ala Ala Thr 
                245                 250                 255     


Leu Arg Ile Ile Glu Glu Asn Ile Pro Glu Leu Leu Ser Leu Asn Leu 
            260                 265                 270         


Ser Asn Asn Arg Leu Tyr Arg Leu Asp Asp Met Ser Ser Ile Val Gln 
        275                 280                 285             


Lys Ala Pro Asn Leu Lys Ile Leu Asn Leu Ser Gly Asn Glu Leu Lys 
    290                 295                 300                 


Ser Glu Arg Glu Leu Asp Lys Ile Lys Gly Leu Lys Leu Glu Glu Leu 
305                 310                 315                 320 


Trp Leu Asp Gly Asn Ser Leu Cys Asp Thr Phe Arg Asp Gln Ser Thr 
                325                 330                 335     


Tyr Ile Ser Ala Ile Arg Glu Arg Phe Pro Lys Leu Leu Arg Leu Asp 
            340                 345                 350         


Gly His Glu Leu Pro Pro Pro Ile Ala Phe Asp Val Glu Ala Pro Thr 
        355                 360                 365             


Thr Leu Pro Pro Cys Lys Gly Ser Tyr Phe Gly Thr Glu Asn Leu Lys 
    370                 375                 380                 


Ser Leu Val Leu His Phe Leu Gln Gln Tyr Tyr Ala Ile Tyr Asp Ser 
385                 390                 395                 400 


Gly Asp Arg Gln Gly Leu Leu Asp Ala Tyr His Asp Gly Ala Cys Cys 
                405                 410                 415     


Ser Leu Ser Ile Pro Phe Ile Pro Gln Asn Pro Ala Arg Ser Ser Leu 
            420                 425                 430         


Ala Glu Tyr Phe Lys Asp Ser Arg Asn Val Lys Lys Leu Lys Asp Pro 
        435                 440                 445             


Thr Leu Arg Phe Arg Leu Leu Lys His Thr Arg Leu Asn Val Val Ala 
    450                 455                 460                 


Phe Leu Asn Glu Leu Pro Lys Thr Gln His Asp Val Asn Ser Phe Val 
465                 470                 475                 480 


Val Asp Ile Ser Ala Gln Thr Ser Thr Leu Leu Cys Phe Ser Val Asn 
                485                 490                 495     


Gly Val Phe Lys Glu Val Asp Gly Lys Ser Arg Asp Ser Leu Arg Ala 
            500                 505                 510         


Phe Thr Arg Thr Phe Ile Ala Val Pro Ala Ser Asn Ser Gly Leu Cys 
        515                 520                 525             


Ile Val Asn Asp Glu Leu Phe Val Arg Asn Ala Ser Ser Glu Glu Ile 
    530                 535                 540                 


Gln Arg Ala Phe Ala Met Pro Ala Pro Thr Pro Ser Ser Ser Pro Val 
545                 550                 555                 560 


Pro Thr Leu Ser Pro Glu Gln Gln Glu Met Leu Gln Ala Phe Ser Thr 
                565                 570                 575     


Gln Ser Gly Met Asn Leu Glu Trp Ser Gln Lys Cys Leu Gln Asp Asn 
            580                 585                 590         


Asn Trp Asp Tyr Thr Arg Ser Ala Gln Ala Phe Thr His Leu Lys Ala 
        595                 600                 605             


Lys Gly Glu Ile Pro Glu Val Ala Phe Met Lys 
    610                 615                 


<210>  1161
<211>  1792
<212>  DNA
<213>  Homosapiens

<400>  1161
gtgacgtggc cgcttccagt ctttggtcgg gtttcggcgg cttcagtgct cggggaggag     60

gcagtgacgg ccggtgagat tggaagtggc ggcggcggca ggcggcagag gggagtccga    120

ggttatgcgt ctcaatgatc ccgcggaaac gctacgggtc taagaacacg gatcagggtg    180

tctacctggg tctctcaaag acacaggtcc tgtcccctgc aactgctggc agtagcagca    240

gcgacatcgc ccctctgccc cccccagtga ccctcgtccc tccccctccc gacaccatgt    300

cctgccggga tcggacccag gagtttctgt ctgcctgcaa gtcgctgcag acccgtcaga    360

atggaatcca gacaaataag ccagctttgc gtgctgtccg acaacgcagt gaattcaccc    420

tcatggccaa gcgcattggg aaagacctta gcaacacatt tgccaagctg gagaagctga    480

caatcttggc aaagcgcaag tccctctttg atgataaagc agtggaaatt gaagagctaa    540

catatatcat caaacaggac atcaatagcc tcaacaaaca aattgctcag ctccaggatt    600

tcgtgagagc caagggcagc cagagtggcc ggcacctgca gacccactcc aacaccattg    660

tggtctcctt gcagtcgaaa ctggcttcta tgtccaatga cttcaaatcg gttttagaag    720

tgaggacaga gaacctgaag cagcagagga gccggagaga gcagttctcc cgggcacctg    780

tgtcagccct gccccttgcc cctaaccacc tgggcggtgg tgctgtggtt ctgggggcag    840

agtcccatgc ctccaaggat gtcgccatcg acatgatgga ctctcggacc agccagcagc    900

tgcagctcat tgacgagcag gattcctaca tccagagtcg ggcagacacc atgcagaaca    960

ttgagtcgac aattgttgag ttgggctcca tctttcagca gttggcacac atggttaagg   1020

aacaggagga aaccattcag aggatcgacg agaacgtgct aggagcccag ctggacgttg   1080

aggccgccca ttcagagatc ctcaagtact tccagtctgt cacctccaac cggtggctca   1140

tggtcaaaat cttcctcatc ctcattgtct tcttcatcat ctttgtggtc ttccttgctt   1200

gaaccctctc tactctgagg cactctgttg gggtttggga ccctcctggg aaggcaagtg   1260

gccagtgctg ccactgagcc tgtgcagggt acttgggaga aaggccctgt ttccctggaa   1320

ctgctaagaa tgaccactgc ccctgatccc ccaccccttg cctctggcca ccctgtcttc   1380

cccccaccac cctcaggcct atgaaacaca cagggttcta gatttgaact ctgctgtgaa   1440

gtgactggaa gggagcagag gccagctggg ggccagtggg ggaggttgtt tccactagga   1500

gatttttata aaccctctcc agcctctccc aaaggaagcg ttggcagcaa agggagatga   1560

tgcccttacc caccttcctg tgagtgaaga gaggaagcag ccccagggac caattttccc   1620

aattgacctc tttcttcctc tttcaccatg tgaggcaggg agccctgagc ccttcagctg   1680

cctgcacaac ccctgacatt ggctgctggt gactcaatct gccaaatgtg ctgcagctcg   1740

ttttctccca attacagcaa gactgtcagc ctcaaaaaaa aaaaaaaaaa aa           1792


<210>  1162
<211>  301
<212>  PRT
<213>  Homosapiens

<400>  1162

Met Ser Cys Arg Asp Arg Thr Gln Glu Phe Leu Ser Ala Cys Lys Ser 
1               5                   10                  15      


Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr Asn Lys Pro Ala Leu Arg 
            20                  25                  30          


Ala Val Arg Gln Arg Ser Glu Phe Thr Leu Met Ala Lys Arg Ile Gly 
        35                  40                  45              


Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu Glu Lys Leu Thr Ile Leu 
    50                  55                  60                  


Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys Ala Val Glu Ile Glu Glu 
65                  70                  75                  80  


Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn Ser Leu Asn Lys Gln Ile 
                85                  90                  95      


Ala Gln Leu Gln Asp Phe Val Arg Ala Lys Gly Ser Gln Ser Gly Arg 
            100                 105                 110         


His Leu Gln Thr His Ser Asn Thr Ile Val Val Ser Leu Gln Ser Lys 
        115                 120                 125             


Leu Ala Ser Met Ser Asn Asp Phe Lys Ser Val Leu Glu Val Arg Thr 
    130                 135                 140                 


Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg Glu Gln Phe Ser Arg Ala 
145                 150                 155                 160 


Pro Val Ser Ala Leu Pro Leu Ala Pro Asn His Leu Gly Gly Gly Ala 
                165                 170                 175     


Val Val Leu Gly Ala Glu Ser His Ala Ser Lys Asp Val Ala Ile Asp 
            180                 185                 190         


Met Met Asp Ser Arg Thr Ser Gln Gln Leu Gln Leu Ile Asp Glu Gln 
        195                 200                 205             


Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr Met Gln Asn Ile Glu Ser 
    210                 215                 220                 


Thr Ile Val Glu Leu Gly Ser Ile Phe Gln Gln Leu Ala His Met Val 
225                 230                 235                 240 


Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile Asp Glu Asn Val Leu Gly 
                245                 250                 255     


Ala Gln Leu Asp Val Glu Ala Ala His Ser Glu Ile Leu Lys Tyr Phe 
            260                 265                 270         


Gln Ser Val Thr Ser Asn Arg Trp Leu Met Val Lys Ile Phe Leu Ile 
        275                 280                 285             


Leu Ile Val Phe Phe Ile Ile Phe Val Val Phe Leu Ala 
    290                 295                 300     


<210>  1163
<211>  1366
<212>  DNA
<213>  Homosapiens

<400>  1163
tagtaatacc agctgtaatc ccagctactt gggaggctga ggcagaagaa tcgcttgaac     60

ccgggaggcg gaggttgagc aactacactg cgctgcatcg gactcgacgc ccgctggtga    120

cgcacacgct gcgccggaag tgtgaactgt ctgcctccag gctttgtcat ggcggctgct    180

gctgcacgct ggaaccatgt gtgggtcggc accgagactg ggatcttgaa aggggtaaat    240

cttcagcgaa aacaggcggc gaacctcacg gccggaggac agccgcggcg cgaggaggca    300

gtgagcgccc tgtgttgggg caccggcggc gagacccaga tgctggtggg ctgcgcggac    360

aggacggtga agcacttcag caccgaggat ggcatattcc agggtcagag acactgcccg    420

ggcggggagg gcatgttccg tggcctcgcc caggccgacg gcaccctcat cacatgtgtg    480

gattctggga ttctcagagt ctggcatgac aaggacaagg acacatcctc tgacccactc    540

ctggaactga gagtgggccc tggggtgtgt aggatgcgcc aagacccagc acacccccat    600

gtggttgcca caggtgggaa agagaatgct ttgaagatat gggacctgca gggctctgag    660

gaacctgtgt tcagggccaa gaacgtgcgg aatgactggc tggacttgcg ggttcccatc    720

tgggaccagg acatacagtt tctcccagga tcacagaagc ttgtcacctg cacagggtac    780

caccaggtcc gtgtttatga tccagcatcc ccccagcgcc ggccagtcct agagaccacc    840

tatggagagt actcactaac agccatgacc ctcactccgg gaggcaactc agtgattgtg    900

ggaaacactc atgggcagct ggcagaaatt gaccttcggc aagggcgtct actgggctgt    960

ctgaaggggc tggcaggcag tgtgcgtggg ttgcagtgcc acccttcaaa gcctctacta   1020

gcctcctgtg gcttggacag agtcttgagg atacacggga cccagaatcc acggggtctg   1080

gagcataagg tttatctcaa gtctcaattg aactgcctcc tcttgtcagg cagggacaac   1140

tgggaggatg agccccaaga gcctcaagaa cccaacaagg tgcccctaga agacacagag   1200

acagatgaac tttgggcatc cttggaggca gctgccaagc ggaagctctc gggtttggag   1260

cagccccaag gagctctcca aacgagacgg agaaagaaga agcggcctgg gtccaccagc   1320

ccctgacgcc cctgtgccca ctttgtaaat aaactgctga acaccc                  1366


<210>  1164
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  1164

Met Ala Ala Ala Ala Ala Arg Trp Asn His Val Trp Val Gly Thr Glu 
1               5                   10                  15      


Thr Gly Ile Leu Lys Gly Val Asn Leu Gln Arg Lys Gln Ala Ala Asn 
            20                  25                  30          


Leu Thr Ala Gly Gly Gln Pro Arg Arg Glu Glu Ala Val Ser Ala Leu 
        35                  40                  45              


Cys Trp Gly Thr Gly Gly Glu Thr Gln Met Leu Val Gly Cys Ala Asp 
    50                  55                  60                  


Arg Thr Val Lys His Phe Ser Thr Glu Asp Gly Ile Phe Gln Gly Gln 
65                  70                  75                  80  


Arg His Cys Pro Gly Gly Glu Gly Met Phe Arg Gly Leu Ala Gln Ala 
                85                  90                  95      


Asp Gly Thr Leu Ile Thr Cys Val Asp Ser Gly Ile Leu Arg Val Trp 
            100                 105                 110         


His Asp Lys Asp Lys Asp Thr Ser Ser Asp Pro Leu Leu Glu Leu Arg 
        115                 120                 125             


Val Gly Pro Gly Val Cys Arg Met Arg Gln Asp Pro Ala His Pro His 
    130                 135                 140                 


Val Val Ala Thr Gly Gly Lys Glu Asn Ala Leu Lys Ile Trp Asp Leu 
145                 150                 155                 160 


Gln Gly Ser Glu Glu Pro Val Phe Arg Ala Lys Asn Val Arg Asn Asp 
                165                 170                 175     


Trp Leu Asp Leu Arg Val Pro Ile Trp Asp Gln Asp Ile Gln Phe Leu 
            180                 185                 190         


Pro Gly Ser Gln Lys Leu Val Thr Cys Thr Gly Tyr His Gln Val Arg 
        195                 200                 205             


Val Tyr Asp Pro Ala Ser Pro Gln Arg Arg Pro Val Leu Glu Thr Thr 
    210                 215                 220                 


Tyr Gly Glu Tyr Ser Leu Thr Ala Met Thr Leu Thr Pro Gly Gly Asn 
225                 230                 235                 240 


Ser Val Ile Val Gly Asn Thr His Gly Gln Leu Ala Glu Ile Asp Leu 
                245                 250                 255     


Arg Gln Gly Arg Leu Leu Gly Cys Leu Lys Gly Leu Ala Gly Ser Val 
            260                 265                 270         


Arg Gly Leu Gln Cys His Pro Ser Lys Pro Leu Leu Ala Ser Cys Gly 
        275                 280                 285             


Leu Asp Arg Val Leu Arg Ile His Gly Thr Gln Asn Pro Arg Gly Leu 
    290                 295                 300                 


Glu His Lys Val Tyr Leu Lys Ser Gln Leu Asn Cys Leu Leu Leu Ser 
305                 310                 315                 320 


Gly Arg Asp Asn Trp Glu Asp Glu Pro Gln Glu Pro Gln Glu Pro Asn 
                325                 330                 335     


Lys Val Pro Leu Glu Asp Thr Glu Thr Asp Glu Leu Trp Ala Ser Leu 
            340                 345                 350         


Glu Ala Ala Ala Lys Arg Lys Leu Ser Gly Leu Glu Gln Pro Gln Gly 
        355                 360                 365             


Ala Leu Gln Thr Arg Arg Arg Lys Lys Lys Arg Pro Gly Ser Thr Ser 
    370                 375                 380                 


Pro 
385 


<210>  1165
<211>  2408
<212>  DNA
<213>  Homosapiens

<400>  1165
cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg     60

accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc    120

ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg    180

ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc    240

ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg    300

ctggtgtcca gggtctcagc gcgggggacg actcagagtt ggggtctcac tgtgttgccc    360

agactggtct cgaactcttg gcctcaggtg atcctcttcc ctcagcttcc cagaatgccg    420

agatgataga gacggggtct gactgtgtta cccaggctgg tcttcaactc ttggcctcaa    480

gtgatcctcc tgccttagct tccaagaatg ctgaggttac agaaacgggg tttcaccatg    540

ttagccaggc tgatattgaa ttcctgacct caattgatcc gactgcctcg gcctccggaa    600

gtgctgggat tacaggcacc atgagccagg acaccgaggt ggatatgaag gaggtggagc    660

tgaatgagtt agagcccgag aagcagccga tgaacgcggc gtctggggcg gccatgtccc    720

tggcgggagc cgagaagaat ggtctggtga agatcaaggt ggcggaagac gaggcggagg    780

cggcagccgc ggctaagttc acgggcctgt ccaaggagga gctgctgaag gtggcaggca    840

gccccggctg ggtacgcacc cgctgggcac tgctgctgct cttctggctc ggctggctcg    900

gcatgcttgc tggtgccgtg gtcataatcg tgcgagcgcc gcgttgtcgc gagctaccgg    960

cgcagaagtg gtggcacacg ggcgccctct accgcatcgg cgaccttcag gccttccagg   1020

gccacggcgc gggcaacctg gcgggtctga aggggcgtct cgattacctg agctctctga   1080

aggtgaaggg ccttgtgctg ggtccaattc acaagaacca gaaggatgat gtcgctcaga   1140

ctgacttgct gcagatcgac cccaattttg gctccaagga agattttgac agtctcttgc   1200

aatcggctaa aaaaaagagc atccgtgtca ttctggacct tactcccaac taccggggtg   1260

agaactcgtg gttctccact caggttgaca ctgtggccac caaggtgaag gatgctctgg   1320

agttttggct gcaagctggc gtggatgggt tccaggttcg ggacatagag aatctgaagg   1380

atgcatcctc attcttggct gagtggcaaa atatcaccaa gggcttcagt gaagacaggc   1440

tcttgattgc ggggactaac tcctccgacc ttcagcagat cctgagccta ctcgaatcca   1500

acaaagactt gctgttgact agctcatacc tgtctgattc tggttctact ggggagcata   1560

caaaatccct agtcacacag tatttgaatg ccactggcaa tcgctggtgc agctggagtt   1620

tgtctcaggc aaggctcctg acttccttct tgccggctca acttctccga ctctaccagc   1680

tgatgctctt caccctgcca gggacccctg ttttcagcta cggggatgag attggcctgg   1740

atgcagctgc ccttcctgga cagcctatgg aggctccagt catgctgtgg gatgagtcca   1800

gcttccctga catcccaggg gctgtaagtg ccaacatgac tgtgaagggc cagagtgaag   1860

accctggctc cctcctttcc ttgttccggc ggctgagtga ccagcggagt aaggagcgct   1920

ccctactgca tggggacttc cacgcgttct ccgctgggcc tggactcttc tcctatatcc   1980

gccactggga ccagaatgag cgttttctgg tagtgcttaa ctttggggat gtgggcctct   2040

cggctggact gcaggcctcc gacctgcctg ccagcgccag cctgccagcc aaggctgacc   2100

tcctgctcag cacccagcca ggccgtgagg agggctcccc tcttgagctg gaacgcctga   2160

aactggagcc tcacgaaggg ctgctgctcc gcttccccta cgcggcctga cttcagcctg   2220

acatggaccc actacccttc tcctttcctt cccaggccct ttggcttctg atttttctct   2280

tttttaaaaa caaacaaaca aactgttgca gattatgagt gaacccccaa atagggtgtt   2340

ttctgccttc aaataaaagt cacccctgca tggtgaagtc ttccctctgc ttctctcaaa   2400

aaaaaaaa                                                            2408


<210>  1166
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  1166

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Glu Thr Gly Phe His His Val Ser Gln Ala Asp Ile Glu 
            100                 105                 110         


Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser Ala Gly 
        115                 120                 125             


Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val 
    130                 135                 140                 


Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser 
145                 150                 155                 160 


Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys 
                165                 170                 175     


Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe 
            180                 185                 190         


Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly 
        195                 200                 205             


Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp 
    210                 215                 220                 


Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg 
225                 230                 235                 240 


Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr 
                245                 250                 255     


Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu 
            260                 265                 270         


Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys 
        275                 280                 285             


Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala 
    290                 295                 300                 


Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp 
305                 310                 315                 320 


Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile 
                325                 330                 335     


Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr 
            340                 345                 350         


Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp 
        355                 360                 365             


Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu 
    370                 375                 380                 


Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly 
385                 390                 395                 400 


Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu 
                405                 410                 415     


Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr 
            420                 425                 430         


Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser 
        435                 440                 445             


Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp 
    450                 455                 460                 


Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu 
465                 470                 475                 480 


Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val 
                485                 490                 495     


Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly 
            500                 505                 510         


Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro 
        515                 520                 525             


Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser 
    530                 535                 540                 


Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln 
545                 550                 555                 560 


Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser 
                565                 570                 575     


Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu 
            580                 585                 590         


Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly 
        595                 600                 605             


Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala 
    610                 615                 620                 


Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu 
625                 630                 635                 640 


Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg 
                645                 650                 655     


Phe Pro Tyr Ala Ala 
            660     


<210>  1167
<211>  2222
<212>  DNA
<213>  Homosapiens

<400>  1167
cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg     60

accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc    120

ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg    180

ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc    240

ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg    300

ctggtgtcca gggtctcagc gcgggggacg actcagagac ggggtctgac tgtgttaccc    360

aggctggtct tcaactcttg gcctcaagtg atcctcctgc cttagcttcc aagaatgctg    420

aggttacagg caccatgagc caggacaccg aggtggatat gaaggaggtg gagctgaatg    480

agttagagcc cgagaagcag ccgatgaacg cggcgtctgg ggcggccatg tccctggcgg    540

gagccgagaa gaatggtctg gtgaagatca aggtggcgga agacgaggcg gaggcggcag    600

ccgcggctaa gttcacgggc ctgtccaagg aggagctgct gaaggtggca ggcagccccg    660

gctgggtacg cacccgctgg gcactgctgc tgctcttctg gctcggctgg ctcggcatgc    720

ttgctggtgc cgtggtcata atcgtgcgag cgccgcgttg tcgcgagcta ccggcgcaga    780

agtggtggca cacgggcgcc ctctaccgca tcggcgacct tcaggccttc cagggccacg    840

gcgcgggcaa cctggcgggt ctgaaggggc gtctcgatta cctgagctct ctgaaggtga    900

agggccttgt gctgggtcca attcacaaga accagaagga tgatgtcgct cagactgact    960

tgctgcagat cgaccccaat tttggctcca aggaagattt tgacagtctc ttgcaatcgg   1020

ctaaaaaaaa gagcatccgt gtcattctgg accttactcc caactaccgg ggtgagaact   1080

cgtggttctc cactcaggtt gacactgtgg ccaccaaggt gaaggatgct ctggagtttt   1140

ggctgcaagc tggcgtggat gggttccagg ttcgggacat agagaatctg aaggatgcat   1200

cctcattctt ggctgagtgg caaaatatca ccaagggctt cagtgaagac aggctcttga   1260

ttgcggggac taactcctcc gaccttcagc agatcctgag cctactcgaa tccaacaaag   1320

acttgctgtt gactagctca tacctgtctg attctggttc tactggggag catacaaaat   1380

ccctagtcac acagtatttg aatgccactg gcaatcgctg gtgcagctgg agtttgtctc   1440

aggcaaggct cctgacttcc ttcttgccgg ctcaacttct ccgactctac cagctgatgc   1500

tcttcaccct gccagggacc cctgttttca gctacgggga tgagattggc ctggatgcag   1560

ctgcccttcc tggacagcct atggaggctc cagtcatgct gtgggatgag tccagcttcc   1620

ctgacatccc aggggctgta agtgccaaca tgactgtgaa gggccagagt gaagaccctg   1680

gctccctcct ttccttgttc cggcggctga gtgaccagcg gagtaaggag cgctccctac   1740

tgcatgggga cttccacgcg ttctccgctg ggcctggact cttctcctat atccgccact   1800

gggaccagaa tgagcgtttt ctggtagtgc ttaactttgg ggatgtgggc ctctcggctg   1860

gactgcaggc ctccgacctg cctgccagcg ccagcctgcc agccaaggct gacctcctgc   1920

tcagcaccca gccaggccgt gaggagggct cccctcttga gctggaacgc ctgaaactgg   1980

agcctcacga agggctgctg ctccgcttcc cctacgcggc ctgacttcag cctgacatgg   2040

acccactacc cttctccttt ccttcccagg ccctttggct tctgattttt ctctttttta   2100

aaaacaaaca aacaaactgt tgcagattat gagtgaaccc ccaaataggg tgttttctgc   2160

cttcaaataa aagtcacccc tgcatggtga agtcttccct ctgcttctct caaaaaaaaa   2220

aa                                                                  2222


<210>  1168
<211>  599
<212>  PRT
<213>  Homosapiens

<400>  1168

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 
        35                  40                  45              


Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 
    50                  55                  60                  


Ala Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 
65                  70                  75                  80  


Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 
                85                  90                  95      


Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 
            100                 105                 110         


Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 
        115                 120                 125             


Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 
    130                 135                 140                 


Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 
145                 150                 155                 160 


Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 
                165                 170                 175     


Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 
            180                 185                 190         


Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 
        195                 200                 205             


Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 
    210                 215                 220                 


Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 
225                 230                 235                 240 


Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 
                245                 250                 255     


Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 
            260                 265                 270         


Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 
        275                 280                 285             


Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 
    290                 295                 300                 


Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 
305                 310                 315                 320 


Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 
                325                 330                 335     


Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 
            340                 345                 350         


Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 
        355                 360                 365             


Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 
    370                 375                 380                 


Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 
385                 390                 395                 400 


Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 
                405                 410                 415     


Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 
            420                 425                 430         


Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 
        435                 440                 445             


Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 
    450                 455                 460                 


Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 
465                 470                 475                 480 


Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 
                485                 490                 495     


Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 
            500                 505                 510         


Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 
        515                 520                 525             


Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 
    530                 535                 540                 


Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 
545                 550                 555                 560 


Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 
                565                 570                 575     


Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 
            580                 585                 590         


Leu Arg Phe Pro Tyr Ala Ala 
        595                 


<210>  1169
<211>  2318
<212>  DNA
<213>  Homosapiens

<400>  1169
cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg     60

accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc    120

ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg    180

ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc    240

ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg    300

ctggtgtcca gggtctcagc gcgggggacg actcagagac ggggtctgac tgtgttaccc    360

aggctggtct tcaactcttg gcctcaagtg atcctcctgc cttagcttcc aagaatgctg    420

aggttacagt agaaacgggg tttcaccatg ttagccaggc tgatattgaa ttcctgacct    480

caattgatcc gactgcctcg gcctccggaa gtgctgggat tacaggcacc atgagccagg    540

acaccgaggt ggatatgaag gaggtggagc tgaatgagtt agagcccgag aagcagccga    600

tgaacgcggc gtctggggcg gccatgtccc tggcgggagc cgagaagaat ggtctggtga    660

agatcaaggt ggcggaagac gaggcggagg cggcagccgc ggctaagttc acgggcctgt    720

ccaaggagga gctgctgaag gtggcaggca gccccggctg ggtacgcacc cgctgggcac    780

tgctgctgct cttctggctc ggctggctcg gcatgcttgc tggtgccgtg gtcataatcg    840

tgcgagcgcc gcgttgtcgc gagctaccgg cgcagaagtg gtggcacacg ggcgccctct    900

accgcatcgg cgaccttcag gccttccagg gccacggcgc gggcaacctg gcgggtctga    960

aggggcgtct cgattacctg agctctctga aggtgaaggg ccttgtgctg ggtccaattc   1020

acaagaacca gaaggatgat gtcgctcaga ctgacttgct gcagatcgac cccaattttg   1080

gctccaagga agattttgac agtctcttgc aatcggctaa aaaaaagagc atccgtgtca   1140

ttctggacct tactcccaac taccggggtg agaactcgtg gttctccact caggttgaca   1200

ctgtggccac caaggtgaag gatgctctgg agttttggct gcaagctggc gtggatgggt   1260

tccaggttcg ggacatagag aatctgaagg atgcatcctc attcttggct gagtggcaaa   1320

atatcaccaa gggcttcagt gaagacaggc tcttgattgc ggggactaac tcctccgacc   1380

ttcagcagat cctgagccta ctcgaatcca acaaagactt gctgttgact agctcatacc   1440

tgtctgattc tggttctact ggggagcata caaaatccct agtcacacag tatttgaatg   1500

ccactggcaa tcgctggtgc agctggagtt tgtctcaggc aaggctcctg acttccttct   1560

tgccggctca acttctccga ctctaccagc tgatgctctt caccctgcca gggacccctg   1620

ttttcagcta cggggatgag attggcctgg atgcagctgc ccttcctgga cagcctatgg   1680

aggctccagt catgctgtgg gatgagtcca gcttccctga catcccaggg gctgtaagtg   1740

ccaacatgac tgtgaagggc cagagtgaag accctggctc cctcctttcc ttgttccggc   1800

ggctgagtga ccagcggagt aaggagcgct ccctactgca tggggacttc cacgcgttct   1860

ccgctgggcc tggactcttc tcctatatcc gccactggga ccagaatgag cgttttctgg   1920

tagtgcttaa ctttggggat gtgggcctct cggctggact gcaggcctcc gacctgcctg   1980

ccagcgccag cctgccagcc aaggctgacc tcctgctcag cacccagcca ggccgtgagg   2040

agggctcccc tcttgagctg gaacgcctga aactggagcc tcacgaaggg ctgctgctcc   2100

gcttccccta cgcggcctga cttcagcctg acatggaccc actacccttc tcctttcctt   2160

cccaggccct ttggcttctg atttttctct tttttaaaaa caaacaaaca aactgttgca   2220

gattatgagt gaacccccaa atagggtgtt ttctgccttc aaataaaagt cacccctgca   2280

tggtgaagtc ttccctctgc ttctctcaaa aaaaaaaa                           2318


<210>  1170
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  1170

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly 
        35                  40                  45              


Leu Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn 
    50                  55                  60                  


Ala Glu Val Thr Val Glu Thr Gly Phe His His Val Ser Gln Ala Asp 
65                  70                  75                  80  


Ile Glu Phe Leu Thr Ser Ile Asp Pro Thr Ala Ser Ala Ser Gly Ser 
                85                  90                  95      


Ala Gly Ile Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys 
            100                 105                 110         


Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala 
        115                 120                 125             


Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu 
    130                 135                 140                 


Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser 
                165                 170                 175     


Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu 
            180                 185                 190         


Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala 
        195                 200                 205             


Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala 
    210                 215                 220                 


Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly 
225                 230                 235                 240 


Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys 
                245                 250                 255     


Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp 
            260                 265                 270         


Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys 
        275                 280                 285             


Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg 
    290                 295                 300                 


Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe 
305                 310                 315                 320 


Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu 
                325                 330                 335     


Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu 
            340                 345                 350         


Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr 
        355                 360                 365             


Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser 
    370                 375                 380                 


Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu 
385                 390                 395                 400 


Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr 
                405                 410                 415     


Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys 
            420                 425                 430         


Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala 
        435                 440                 445             


Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr 
    450                 455                 460                 


Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu 
465                 470                 475                 480 


Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser 
                485                 490                 495     


Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly 
            500                 505                 510         


Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser 
        515                 520                 525             


Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala 
    530                 535                 540                 


Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln 
545                 550                 555                 560 


Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser 
                565                 570                 575     


Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala 
            580                 585                 590         


Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser 
        595                 600                 605             


Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu 
    610                 615                 620                 


Leu Arg Phe Pro Tyr Ala Ala 
625                 630     


<210>  1171
<211>  2129
<212>  DNA
<213>  Homosapiens

<400>  1171
cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg     60

accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc    120

ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg    180

ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc    240

ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg    300

ctggtgtcca gggtctcagc gcgggggacg actcaggcac catgagccag gacaccgagg    360

tggatatgaa ggaggtggag ctgaatgagt tagagcccga gaagcagccg atgaacgcgg    420

cgtctggggc ggccatgtcc ctggcgggag ccgagaagaa tggtctggtg aagatcaagg    480

tggcggaaga cgaggcggag gcggcagccg cggctaagtt cacgggcctg tccaaggagg    540

agctgctgaa ggtggcaggc agccccggct gggtacgcac ccgctgggca ctgctgctgc    600

tcttctggct cggctggctc ggcatgcttg ctggtgccgt ggtcataatc gtgcgagcgc    660

cgcgttgtcg cgagctaccg gcgcagaagt ggtggcacac gggcgccctc taccgcatcg    720

gcgaccttca ggccttccag ggccacggcg cgggcaacct ggcgggtctg aaggggcgtc    780

tcgattacct gagctctctg aaggtgaagg gccttgtgct gggtccaatt cacaagaacc    840

agaaggatga tgtcgctcag actgacttgc tgcagatcga ccccaatttt ggctccaagg    900

aagattttga cagtctcttg caatcggcta aaaaaaagag catccgtgtc attctggacc    960

ttactcccaa ctaccggggt gagaactcgt ggttctccac tcaggttgac actgtggcca   1020

ccaaggtgaa ggatgctctg gagttttggc tgcaagctgg cgtggatggg ttccaggttc   1080

gggacataga gaatctgaag gatgcatcct cattcttggc tgagtggcaa aatatcacca   1140

agggcttcag tgaagacagg ctcttgattg cggggactaa ctcctccgac cttcagcaga   1200

tcctgagcct actcgaatcc aacaaagact tgctgttgac tagctcatac ctgtctgatt   1260

ctggttctac tggggagcat acaaaatccc tagtcacaca gtatttgaat gccactggca   1320

atcgctggtg cagctggagt ttgtctcagg caaggctcct gacttccttc ttgccggctc   1380

aacttctccg actctaccag ctgatgctct tcaccctgcc agggacccct gttttcagct   1440

acggggatga gattggcctg gatgcagctg cccttcctgg acagcctatg gaggctccag   1500

tcatgctgtg ggatgagtcc agcttccctg acatcccagg ggctgtaagt gccaacatga   1560

ctgtgaaggg ccagagtgaa gaccctggct ccctcctttc cttgttccgg cggctgagtg   1620

accagcggag taaggagcgc tccctactgc atggggactt ccacgcgttc tccgctgggc   1680

ctggactctt ctcctatatc cgccactggg accagaatga gcgttttctg gtagtgctta   1740

actttgggga tgtgggcctc tcggctggac tgcaggcctc cgacctgcct gccagcgcca   1800

gcctgccagc caaggctgac ctcctgctca gcacccagcc aggccgtgag gagggctccc   1860

ctcttgagct ggaacgcctg aaactggagc ctcacgaagg gctgctgctc cgcttcccct   1920

acgcggcctg acttcagcct gacatggacc cactaccctt ctcctttcct tcccaggccc   1980

tttggcttct gatttttctc ttttttaaaa acaaacaaac aaactgttgc agattatgag   2040

tgaaccccca aatagggtgt tttctgcctt caaataaaag tcacccctgc atggtgaagt   2100

cttccctctg cttctctcaa aaaaaaaaa                                     2129


<210>  1172
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  1172

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met 
        35                  40                  45              


Lys Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn 
    50                  55                  60                  


Ala Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly 
65                  70                  75                  80  


Leu Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala 
                85                  90                  95      


Ala Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly 
            100                 105                 110         


Ser Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp 
        115                 120                 125             


Leu Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg 
    130                 135                 140                 


Ala Pro Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly 
145                 150                 155                 160 


Ala Leu Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala 
                165                 170                 175     


Gly Asn Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu 
            180                 185                 190         


Lys Val Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp 
        195                 200                 205             


Asp Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser 
    210                 215                 220                 


Lys Glu Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile 
225                 230                 235                 240 


Arg Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp 
                245                 250                 255     


Phe Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu 
            260                 265                 270         


Glu Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile 
        275                 280                 285             


Glu Asn Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile 
    290                 295                 300                 


Thr Lys Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser 
305                 310                 315                 320 


Ser Asp Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu 
                325                 330                 335     


Leu Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His 
            340                 345                 350         


Thr Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp 
        355                 360                 365             


Cys Ser Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro 
    370                 375                 380                 


Ala Gln Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly 
385                 390                 395                 400 


Thr Pro Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala 
                405                 410                 415     


Leu Pro Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser 
            420                 425                 430         


Ser Phe Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys 
        435                 440                 445             


Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu 
    450                 455                 460                 


Ser Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His 
465                 470                 475                 480 


Ala Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp 
                485                 490                 495     


Gln Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu 
            500                 505                 510         


Ser Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro 
        515                 520                 525             


Ala Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly 
    530                 535                 540                 


Ser Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu 
545                 550                 555                 560 


Leu Leu Arg Phe Pro Tyr Ala Ala 
                565             


<210>  1173
<211>  1997
<212>  DNA
<213>  Homosapiens

<400>  1173
agtccccgag gttccacctt aaggggcggg ccggggcggg gctccgctgc cccttcccag     60

aggccgcgcc tgctgctgag cagatgcagt agccgaaact gcgcggaggc acagaggccg    120

gggagagcgt tctgggtccg agggtccagg taggggttga gccaccatct gaccgcaagc    180

tgcgtcgtgt cgccggttct gcaggcacca tgagccagga caccgaggtg gatatgaagg    240

aggtggagct gaatgagtta gagcccgaga agcagccgat gaacgcggcg tctggggcgg    300

ccatgtccct ggcgggagcc gagaagaatg gtctggtgaa gatcaaggtg gcggaagacg    360

aggcggaggc ggcagccgcg gctaagttca cgggcctgtc caaggaggag ctgctgaagg    420

tggcaggcag ccccggctgg gtacgcaccc gctgggcact gctgctgctc ttctggctcg    480

gctggctcgg catgcttgct ggtgccgtgg tcataatcgt gcgagcgccg cgttgtcgcg    540

agctaccggc gcagaagtgg tggcacacgg gcgccctcta ccgcatcggc gaccttcagg    600

ccttccaggg ccacggcgcg ggcaacctgg cgggtctgaa ggggcgtctc gattacctga    660

gctctctgaa ggtgaagggc cttgtgctgg gtccaattca caagaaccag aaggatgatg    720

tcgctcagac tgacttgctg cagatcgacc ccaattttgg ctccaaggaa gattttgaca    780

gtctcttgca atcggctaaa aaaaagagca tccgtgtcat tctggacctt actcccaact    840

accggggtga gaactcgtgg ttctccactc aggttgacac tgtggccacc aaggtgaagg    900

atgctctgga gttttggctg caagctggcg tggatgggtt ccaggttcgg gacatagaga    960

atctgaagga tgcatcctca ttcttggctg agtggcaaaa tatcaccaag ggcttcagtg   1020

aagacaggct cttgattgcg gggactaact cctccgacct tcagcagatc ctgagcctac   1080

tcgaatccaa caaagacttg ctgttgacta gctcatacct gtctgattct ggttctactg   1140

gggagcatac aaaatcccta gtcacacagt atttgaatgc cactggcaat cgctggtgca   1200

gctggagttt gtctcaggca aggctcctga cttccttctt gccggctcaa cttctccgac   1260

tctaccagct gatgctcttc accctgccag ggacccctgt tttcagctac ggggatgaga   1320

ttggcctgga tgcagctgcc cttcctggac agcctatgga ggctccagtc atgctgtggg   1380

atgagtccag cttccctgac atcccagggg ctgtaagtgc caacatgact gtgaagggcc   1440

agagtgaaga ccctggctcc ctcctttcct tgttccggcg gctgagtgac cagcggagta   1500

aggagcgctc cctactgcat ggggacttcc acgcgttctc cgctgggcct ggactcttct   1560

cctatatccg ccactgggac cagaatgagc gttttctggt agtgcttaac tttggggatg   1620

tgggcctctc ggctggactg caggcctccg acctgcctgc cagcgccagc ctgccagcca   1680

aggctgacct cctgctcagc acccagccag gccgtgagga gggctcccct cttgagctgg   1740

aacgcctgaa actggagcct cacgaagggc tgctgctccg cttcccctac gcggcctgac   1800

ttcagcctga catggaccca ctacccttct cctttccttc ccaggccctt tggcttctga   1860

tttttctctt ttttaaaaac aaacaaacaa actgttgcag attatgagtg aacccccaaa   1920

tagggtgttt tctgccttca aataaaagtc acccctgcat ggtgaagtct tccctctgct   1980

tctctcaaaa aaaaaaa                                                  1997


<210>  1174
<211>  529
<212>  PRT
<213>  Homosapiens

<400>  1174

Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 
            100                 105                 110         


Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 
        115                 120                 125             


Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys 
    130                 135                 140                 


Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu 
145                 150                 155                 160 


Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu 
                165                 170                 175     


Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu 
            180                 185                 190         


Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr 
        195                 200                 205             


Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr 
    210                 215                 220                 


Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly 
225                 230                 235                 240 


Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser 
                245                 250                 255     


Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp 
            260                 265                 270         


Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu 
        275                 280                 285             


Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln 
305                 310                 315                 320 


Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln 
                325                 330                 335     


Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr 
            340                 345                 350         


Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly 
        355                 360                 365             


Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu 
    370                 375                 380                 


Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly 
385                 390                 395                 400 


Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly 
                405                 410                 415     


Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu 
            420                 425                 430         


Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly 
        435                 440                 445             


Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val 
    450                 455                 460                 


Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser 
465                 470                 475                 480 


Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu 
                485                 490                 495     


Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg 
            500                 505                 510         


Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala 
        515                 520                 525             


Ala 
    


<210>  1175
<211>  2315
<212>  DNA
<213>  Homosapiens

<400>  1175
cctgaacttg cggcgcgaaa aaggcgcgca tgcgtcctac gggagcgtgc tggctcaccg     60

accgcattgc ggcttggttt tctcacccag tgcatgtggc aggagcggtg agatcactgc    120

ctcacggcga tcctggactg acggtcacga ctgcctaccc tctaaccctg ttctgagctg    180

ccccttgccc acacacccca aacctgtgtg caggatccgc ctccatggag ctacagcctc    240

ctgaagcctc gatcgccgtc gtgtcgattc cgcgccagtt gcctggctca cattcggagg    300

ctggtgtcca gggtctcagc gcgggggacg actcagagtt ggggtctcac tgtgttgccc    360

agactggtct cgaactcttg gcctcaggtg atcctcttcc ctcagcttcc cagaatgccg    420

agatgataga gacggggtct gactgtgtta cccaggctgg tcttcaactc ttggcctcaa    480

gtgatcctcc tgccttagct tccaagaatg ctgaggttac aggcaccatg agccaggaca    540

ccgaggtgga tatgaaggag gtggagctga atgagttaga gcccgagaag cagccgatga    600

acgcggcgtc tggggcggcc atgtccctgg cgggagccga gaagaatggt ctggtgaaga    660

tcaaggtggc ggaagacgag gcggaggcgg cagccgcggc taagttcacg ggcctgtcca    720

aggaggagct gctgaaggtg gcaggcagcc ccggctgggt acgcacccgc tgggcactgc    780

tgctgctctt ctggctcggc tggctcggca tgcttgctgg tgccgtggtc ataatcgtgc    840

gagcgccgcg ttgtcgcgag ctaccggcgc agaagtggtg gcacacgggc gccctctacc    900

gcatcggcga ccttcaggcc ttccagggcc acggcgcggg caacctggcg ggtctgaagg    960

ggcgtctcga ttacctgagc tctctgaagg tgaagggcct tgtgctgggt ccaattcaca   1020

agaaccagaa ggatgatgtc gctcagactg acttgctgca gatcgacccc aattttggct   1080

ccaaggaaga ttttgacagt ctcttgcaat cggctaaaaa aaagagcatc cgtgtcattc   1140

tggaccttac tcccaactac cggggtgaga actcgtggtt ctccactcag gttgacactg   1200

tggccaccaa ggtgaaggat gctctggagt tttggctgca agctggcgtg gatgggttcc   1260

aggttcggga catagagaat ctgaaggatg catcctcatt cttggctgag tggcaaaata   1320

tcaccaaggg cttcagtgaa gacaggctct tgattgcggg gactaactcc tccgaccttc   1380

agcagatcct gagcctactc gaatccaaca aagacttgct gttgactagc tcatacctgt   1440

ctgattctgg ttctactggg gagcatacaa aatccctagt cacacagtat ttgaatgcca   1500

ctggcaatcg ctggtgcagc tggagtttgt ctcaggcaag gctcctgact tccttcttgc   1560

cggctcaact tctccgactc taccagctga tgctcttcac cctgccaggg acccctgttt   1620

tcagctacgg ggatgagatt ggcctggatg cagctgccct tcctggacag cctatggagg   1680

ctccagtcat gctgtgggat gagtccagct tccctgacat cccaggggct gtaagtgcca   1740

acatgactgt gaagggccag agtgaagacc ctggctccct cctttccttg ttccggcggc   1800

tgagtgacca gcggagtaag gagcgctccc tactgcatgg ggacttccac gcgttctccg   1860

ctgggcctgg actcttctcc tatatccgcc actgggacca gaatgagcgt tttctggtag   1920

tgcttaactt tggggatgtg ggcctctcgg ctggactgca ggcctccgac ctgcctgcca   1980

gcgccagcct gccagccaag gctgacctcc tgctcagcac ccagccaggc cgtgaggagg   2040

gctcccctct tgagctggaa cgcctgaaac tggagcctca cgaagggctg ctgctccgct   2100

tcccctacgc ggcctgactt cagcctgaca tggacccact acccttctcc tttccttccc   2160

aggccctttg gcttctgatt tttctctttt ttaaaaacaa acaaacaaac tgttgcagat   2220

tatgagtgaa cccccaaata gggtgttttc tgccttcaaa taaaagtcac ccctgcatgg   2280

tgaagtcttc cctctgcttc tctcaaaaaa aaaaa                              2315


<210>  1176
<211>  630
<212>  PRT
<213>  Homosapiens

<400>  1176

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 
            100                 105                 110         


Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 
        115                 120                 125             


Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 
    130                 135                 140                 


Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 
                165                 170                 175     


Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 
            180                 185                 190         


Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 
        195                 200                 205             


Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 
    210                 215                 220                 


Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 
225                 230                 235                 240 


Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 
                245                 250                 255     


Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 
            260                 265                 270         


Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 
        275                 280                 285             


Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 
    290                 295                 300                 


Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 
305                 310                 315                 320 


Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 
                325                 330                 335     


Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 
            340                 345                 350         


Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 
        355                 360                 365             


Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 
    370                 375                 380                 


Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 
385                 390                 395                 400 


Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 
                405                 410                 415     


Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 
            420                 425                 430         


Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 
        435                 440                 445             


Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 
    450                 455                 460                 


Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 
                485                 490                 495     


Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 
            500                 505                 510         


Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 
        515                 520                 525             


Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 
    530                 535                 540                 


Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 
545                 550                 555                 560 


Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 
                565                 570                 575     


Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 
            580                 585                 590         


Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 
        595                 600                 605             


Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 
    610                 615                 620                 


Arg Phe Pro Tyr Ala Ala 
625                 630 


<210>  1177
<211>  2863
<212>  DNA
<213>  Homosapiens

<400>  1177
tggggctcaa attgggtgcc ctggtgaagg aggggggcac actccagaac ctagtccaac     60

cccagacgct gcctgaggct tccctccagc tcccctccct tccttttctc cctttcctcc    120

ctccctctct ttccctttct ccctccccgc taaggctggc gtgccagggg gtgggacatg    180

ccaatcactg gctgtgcctc tcccgctgcc agcacagggc gcagctcccc ctgggagcca    240

ggtgtttggg tccctggaga cgccgcaggc ccccagggag gcagtggggc tgaggaccct    300

acagacccct cttcagcccc gtggtgatga ctttcccctg aggaagccct gtagcgtgcc    360

tggaggaagg ggctctccaa ccccagcccc acctagccac catgaacact tcagccccac    420

ctgctgtcag ccccaacatc accgtcctgg caccaggaaa gggtccctgg caagtggcct    480

tcattgggat caccacgggc ctcctgtcgc tagccacagt gacaggcaac ctgctggtac    540

tcatctcttt caaggtcaac acggagctca agacagtcaa taactacttc ctgctgagcc    600

tggcctgtgc tgacctcatc atcggtacct tctccatgaa cctctatacc acgtacctgc    660

tcatgggcca ctgggctctg ggcacgctgg cttgtgacct ctggctggcc ctggactatg    720

tggccagcaa tgcctccgtc atgaatctgc tgctcatcag ctttgaccgc tacttctccg    780

tgactcggcc cctgagctac cgtgccaagc gcacaccccg ccgggcagct ctgatgatcg    840

gcctggcctg gctggtttcc tttgtgctct gggccccagc catcctcttc tggcagtacc    900

tggtagggga gcggacagtg ctagctgggc agtgctacat ccagttcctc tcccagccca    960

tcatcacctt tggcacagcc atggctgcct tctacctccc tgtcacagtc atgtgcacgc   1020

tctactggcg catctaccgg gagacagaga accgagcacg ggagctggca gcccttcagg   1080

gctccgagac gccaggcaaa gggggtggca gcagcagcag ctcagagagg tctcagccag   1140

gggctgaggg ctcaccagag actcctccag gccgctgctg tcgctgctgc cgggccccca   1200

ggctgctgca ggcctacagc tggaaggaag aagaggaaga ggacgaaggc tccatggagt   1260

ccctcacatc ctcagaggga gaggagcctg gctccgaagt ggtgatcaag atgccaatgg   1320

tggaccccga ggcacaggcc cccaccaagc agcccccacg gagctcccca aatacagtca   1380

agaggccgac taagaaaggg cgtgatcgag ctggcaaggg ccagaagccc cgtggaaagg   1440

agcagctggc caagcggaag accttctcgc tggtcaagga gaagaaggcg gctcggaccc   1500

tgagtgccat cctcctggcc ttcatcctca cctggacacc gtacaacatc atggtgctgg   1560

tgtccacctt ctgcaaggac tgtgttcccg agaccctgtg ggagctgggc tactggctgt   1620

gctacgtcaa cagcaccatc aaccccatgt gctacgcact ctgcaacaaa gccttccggg   1680

acacctttcg cctgctgctg ctttgccgct gggacaagag acgctggcgc aagatcccca   1740

agcgccctgg ctccgtgcac cgcactccct cccgccaatg ctgatagtcc cctctcctgc   1800

atccctccac cccagtcccc gggaaaggcc ggtgggaaga gggcaggggc tgcatcctca   1860

gccccagggc cctgctcagg cctcacctgg cttcccagga ccctgggtca ccttcctggg   1920

cagcccagag agaccctgcc aactttccag acttcgctat tcccaggcag ggagggaaac   1980

ccggggaact ggtttttctg ttccctgctg ggtgggaatg cgctcttcac caggaagaag   2040

gcccgggagg aggatccggg ctttggactc cttgtttgcc tttaggcagg aagtcaggag   2100

ccagcagggc gggccaggag aaagaaggct taacattaag tattccttgg cccagcagcg   2160

gcccagattg cggtgtgaga tggtgccccc tggggggcac agccagaaac tgaactggcc   2220

gctgggagaa aagccagatg acagggagct ggggaatccc ctcgcttcat aggcagagcc   2280

cgcccacctg ggccctaggc atactctcca ggattgtcca caaatgtcct cagagggtcc   2340

ctaggtgggt caactccaag gcaaatgtcc aagcatcagc aagacaatga cactggaagg   2400

gtccggcttg gctagtcaca tatcaagtcc cgaggcagca acaggaccag gagccaggtg   2460

tcctgactgt cctacaatat cattttcctg ggagtgggag tcaagtgtgc ctgctatcca   2520

gccgcaaatc cataccccct gccccagaga agcctcagtc cctccctcct ggctcacagc   2580

caccacctgg atggatctgc tccatgcaga tctagccagg cctcccgcat gctgcctgcc   2640

tccggccctg ccccacacag gcctggccca gccagcaggt tctctcctgt gagctcccca   2700

atccaaccca tgcatggcct cccagccacc cggatctcca ggcccagcct ggccccaaat   2760

gttctttcct ttcatcctca gcaagtgctg agtctgtgaa taaagccaca taaccagcgg   2820

gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                     2863


<210>  1178
<211>  460
<212>  PRT
<213>  Homosapiens

<400>  1178

Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys 
    450                 455                 460 


<210>  1179
<211>  2196
<212>  DNA
<213>  Homosapiens

<400>  1179
aaaaactgcc catgcaaggg tcaggtctcc agcagaccct gaaagctgag ctgccctgac     60

ccccaaagtg aggagaagct gcaagggaaa agggagggac agatcaggga gaccggggaa    120

gaaggaggag cagccaagga ggctgctgtc cccccacaga gcagctcgga ctcagctccc    180

ggagcaaccc agctgcggag gcaacggcag tgctgctcct ccagcgaagg acagcaggca    240

ggcagacaga cagaggtcct gggactggaa ggcctcagcc cccagccact gggctgggcc    300

tggcccaatg gcctttaatg acctcctgca gcaggtgggg ggtgtcggcc gcttccagca    360

gatccaggtc accctggtgg tcctccccct gctcctgatg gcttctcaca acaccctgca    420

gaacttcact gctgccatcc ctacccacca ctgccgcccg cctgccgatg ccaacctcag    480

caagaacggg gggctggagg tctggctgcc ccgggacagg caggggcagc ctgagtcctg    540

cctccgcttc acctccccgc agtggggact gccctttctc aatggcacag aagccaatgg    600

cacaggggcc acagagccct gcaccgatgg ctggatctat gacaacagca ccttcccatc    660

taccatcgtg actgagtggg accttgtgtg ctctcacagg gccctacgcc agctggccca    720

gtccttgtac atggtggggg tgctgctcgg agccatggtg ttcggctacc ttgcagacag    780

gctaggccgc cggaaggtac tcatcttgaa ctacctgcag acagctgtgt cagggacctg    840

cgcagccttc gcacccaact tccccatcta ctgcgccttc cggctcctct cgggcatggc    900

tctggctggc atctccctca actgcatgac actgaatgtg gagtggatgc ccattcacac    960

acgggcctgc gtgggcacct tgattggcta tgtctacagc ctgggccagt tcctcctggc   1020

tggtgtggcc tacgctgtgc cccactggcg ccacctgcag ctactggtct ctgcgccttt   1080

ttttgccttc ttcatctact cctggttctt cattgagtcg gcccgctggc actcctcctc   1140

cgggaggctg gacctcaccc tgagggccct gcagagagtc gcccggatca atgggaagcg   1200

ggaagaagga gccaaattga gtatggaggt actccgggcc agtctgcaga aggagctgac   1260

catgggcaaa ggccaggcat cggccatgga gctgctgcgc tgccccaccc tccgccacct   1320

cttcctctgc ctctccatgc tgtggtttgc cactagcttt gcatactatg ggctggtcat   1380

ggacctgcag ggctttggag tcagcatcta cctaatccag gtgatctttg gtgctgtgga   1440

cctgcctgcc aagcttgtgg gcttccttgt catcaactcc ctgggtcgcc ggcctgccca   1500

gatggctgca ctgctgctgg caggcatctg catcctgctc aatggggtga taccccagga   1560

ccagtccatt gtccgaacct ctcttgctgt gctggggaag ggttgtctgg ctgcctcctt   1620

caactgcatc ttcctgtata ctggggaact gtatcccaca atgatccggc agacaggcat   1680

gggaatgggc agcaccatgg cccgagtggg cagcatcgtg agcccactgg tgagcatgac   1740

tgccgagctc tacccctcca tgcctctctt catctacggt gctgttcctg tggccgccag   1800

cgctgtcact gtcctcctgc cagagaccct gggccagcca ctgccagaca cggtgcagga   1860

cctggagagc aggtgggccc ccactcagaa agaagcaggg atatatccca ggaaagggaa   1920

acagacgcga cagcaacaag agcaccagaa gtatatggtc ccactgcagg cctcagcaca   1980

agagaagaat ggactctgag gactgagaag gggccttaca gaaccctaaa gggagggaag   2040

gtcctacagg tctccggcca cccacacaag gaggaggaag aggaaatggt gacccaagtg   2100

tgggggttgt ggttcaggaa agcatcttcc caggggtcca cctcccttta taaaccccac   2160

cagaaccaca tcattaaaag gtttgactgc gcacca                             2196


<210>  1180
<211>  563
<212>  PRT
<213>  Homosapiens

<400>  1180

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Gln Thr Gly Met Gly Met Gly Ser Thr Met 
    450                 455                 460                 


Ala Arg Val Gly Ser Ile Val Ser Pro Leu Val Ser Met Thr Ala Glu 
465                 470                 475                 480 


Leu Tyr Pro Ser Met Pro Leu Phe Ile Tyr Gly Ala Val Pro Val Ala 
                485                 490                 495     


Ala Ser Ala Val Thr Val Leu Leu Pro Glu Thr Leu Gly Gln Pro Leu 
            500                 505                 510         


Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Trp Ala Pro Thr Gln Lys 
        515                 520                 525             


Glu Ala Gly Ile Tyr Pro Arg Lys Gly Lys Gln Thr Arg Gln Gln Gln 
    530                 535                 540                 


Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser Ala Gln Glu Lys 
545                 550                 555                 560 


Asn Gly Leu 
            


<210>  1181
<211>  2064
<212>  DNA
<213>  Homosapiens

<400>  1181
aaaaactgcc catgcaaggg tcaggtctcc agcagaccct gaaagctgag ctgccctgac     60

ccccaaagtg aggagaagct gcaagggaaa agggagggac agatcaggga gaccggggaa    120

gaaggaggag cagccaagga ggctgctgtc cccccacaga gcagctcgga ctcagctccc    180

ggagcaaccc agctgcggag gcaacggcag tgctgctcct ccagcgaagg acagcaggca    240

ggcagacaga cagaggtcct gggactggaa ggcctcagcc cccagccact gggctgggcc    300

tggcccaatg gcctttaatg acctcctgca gcaggtgggg ggtgtcggcc gcttccagca    360

gatccaggtc accctggtgg tcctccccct gctcctgatg gcttctcaca acaccctgca    420

gaacttcact gctgccatcc ctacccacca ctgccgcccg cctgccgatg ccaacctcag    480

caagaacggg gggctggagg tctggctgcc ccgggacagg caggggcagc ctgagtcctg    540

cctccgcttc acctccccgc agtggggact gccctttctc aatggcacag aagccaatgg    600

cacaggggcc acagagccct gcaccgatgg ctggatctat gacaacagca ccttcccatc    660

taccatcgtg actgagtggg accttgtgtg ctctcacagg gccctacgcc agctggccca    720

gtccttgtac atggtggggg tgctgctcgg agccatggtg ttcggctacc ttgcagacag    780

gctaggccgc cggaaggtac tcatcttgaa ctacctgcag acagctgtgt cagggacctg    840

cgcagccttc gcacccaact tccccatcta ctgcgccttc cggctcctct cgggcatggc    900

tctggctggc atctccctca actgcatgac actgaatgtg gagtggatgc ccattcacac    960

acgggcctgc gtgggcacct tgattggcta tgtctacagc ctgggccagt tcctcctggc   1020

tggtgtggcc tacgctgtgc cccactggcg ccacctgcag ctactggtct ctgcgccttt   1080

ttttgccttc ttcatctact cctggttctt cattgagtcg gcccgctggc actcctcctc   1140

cgggaggctg gacctcaccc tgagggccct gcagagagtc gcccggatca atgggaagcg   1200

ggaagaagga gccaaattga gtatggaggt actccgggcc agtctgcaga aggagctgac   1260

catgggcaaa ggccaggcat cggccatgga gctgctgcgc tgccccaccc tccgccacct   1320

cttcctctgc ctctccatgc tgtggtttgc cactagcttt gcatactatg ggctggtcat   1380

ggacctgcag ggctttggag tcagcatcta cctaatccag gtgatctttg gtgctgtgga   1440

cctgcctgcc aagcttgtgg gcttccttgt catcaactcc ctgggtcgcc ggcctgccca   1500

gatggctgca ctgctgctgg caggcatctg catcctgctc aatggggtga taccccagga   1560

ccagtccatt gtccgaacct ctcttgctgt gctggggaag ggttgtctgg ctgcctcctt   1620

caactgcatc ttcctgtata ctggggaact gtatcccaca atgatccgcg ctgtcactgt   1680

cctcctgcca gagaccctgg gccagccact gccagacacg gtgcaggacc tggagagcag   1740

gtgggccccc actcagaaag aagcagggat atatcccagg aaagggaaac agacgcgaca   1800

gcaacaagag caccagaagt atatggtccc actgcaggcc tcagcacaag agaagaatgg   1860

actctgagga ctgagaaggg gccttacaga accctaaagg gagggaaggt cctacaggtc   1920

tccggccacc cacacaagga ggaggaagag gaaatggtga cccaagtgtg ggggttgtgg   1980

ttcaggaaag catcttccca ggggtccacc tccctttata aaccccacca gaaccacatc   2040

attaaaaggt ttgactgcgc acca                                          2064


<210>  1182
<211>  519
<212>  PRT
<213>  Homosapiens

<400>  1182

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Ala Val Thr Val Leu Leu Pro Glu Thr Leu 
    450                 455                 460                 


Gly Gln Pro Leu Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Trp Ala 
465                 470                 475                 480 


Pro Thr Gln Lys Glu Ala Gly Ile Tyr Pro Arg Lys Gly Lys Gln Thr 
                485                 490                 495     


Arg Gln Gln Gln Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser 
            500                 505                 510         


Ala Gln Glu Lys Asn Gly Leu 
        515                 


<210>  1183
<211>  2131
<212>  DNA
<213>  Homosapiens

<400>  1183
aaaaactgcc catgcaaggg tcaggtctcc agcagaccct gaaagctgag ctgccctgac     60

ccccaaagtg aggagaagct gcaagggaaa agggagggac agatcaggga gaccggggaa    120

gaaggaggag cagccaagga ggctgctgtc cccccacaga gcagctcgga ctcagctccc    180

ggagcaaccc agctgcggag gcaacggcag tgctgctcct ccagcgaagg acagcaggca    240

ggcagacaga cagaggtcct gggactggaa ggcctcagcc cccagccact gggctgggcc    300

tggcccaatg gcctttaatg acctcctgct cctgatggct tctcacaaca ccctgcagaa    360

cttcactgct gccatcccta cccaccactg ccgcccgcct gccgatgcca acctcagcaa    420

gaacgggggg ctggaggtct ggctgccccg ggacaggcag gggcagcctg agtcctgcct    480

ccgcttcacc tccccgcagt ggggactgcc ctttctcaat ggcacagaag ccaatggcac    540

aggggccaca gagccctgca ccgatggctg gatctatgac aacagcacct tcccatctac    600

catcgtgact gagtgggacc ttgtgtgctc tcacagggcc ctacgccagc tggcccagtc    660

cttgtacatg gtgggggtgc tgctcggagc catggtgttc ggctaccttg cagacaggct    720

aggccgccgg aaggtactca tcttgaacta cctgcagaca gctgtgtcag ggacctgcgc    780

agccttcgca cccaacttcc ccatctactg cgccttccgg ctcctctcgg gcatggctct    840

ggctggcatc tccctcaact gcatgacact gaatgtggag tggatgccca ttcacacacg    900

ggcctgcgtg ggcaccttga ttggctatgt ctacagcctg ggccagttcc tcctggctgg    960

tgtggcctac gctgtgcccc actggcgcca cctgcagcta ctggtctctg cgcctttttt   1020

tgccttcttc atctactcct ggttcttcat tgagtcggcc cgctggcact cctcctccgg   1080

gaggctggac ctcaccctga gggccctgca gagagtcgcc cggatcaatg ggaagcggga   1140

agaaggagcc aaattgagta tggaggtact ccgggccagt ctgcagaagg agctgaccat   1200

gggcaaaggc caggcatcgg ccatggagct gctgcgctgc cccaccctcc gccacctctt   1260

cctctgcctc tccatgctgt ggtttgccac tagctttgca tactatgggc tggtcatgga   1320

cctgcagggc tttggagtca gcatctacct aatccaggtg atctttggtg ctgtggacct   1380

gcctgccaag cttgtgggct tccttgtcat caactccctg ggtcgccggc ctgcccagat   1440

ggctgcactg ctgctggcag gcatctgcat cctgctcaat ggggtgatac cccaggacca   1500

gtccattgtc cgaacctctc ttgctgtgct ggggaagggt tgtctggctg cctccttcaa   1560

ctgcatcttc ctgtatactg gggaactgta tcccacaatg atccggcaga caggcatggg   1620

aatgggcagc accatggccc gagtgggcag catcgtgagc ccactggtga gcatgactgc   1680

cgagctctac ccctccatgc ctctcttcat ctacggtgct gttcctgtgg ccgccagcgc   1740

tgtcactgtc ctcctgccag agaccctggg ccagccactg ccagacacgg tgcaggacct   1800

ggagagcagg aaagggaaac agacgcgaca gcaacaagag caccagaagt atatggtccc   1860

actgcaggcc tcagcacaag agaagaatgg actctgagga ctgagaaggg gccttacaga   1920

accctaaagg gagggaaggt cctacaggtc tccggccacc cacacaagga ggaggaagag   1980

gaaatggtga cccaagtgtg ggggttgtgg ttcaggaaag catcttccca ggggtccacc   2040

tccctttata aaccccacca gaaccacatc attaaaaggt ttgactgcgc accaaaaaaa   2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  2131


<210>  1184
<211>  529
<212>  PRT
<213>  Homosapiens

<400>  1184

Met Ala Phe Asn Asp Leu Leu Leu Leu Met Ala Ser His Asn Thr Leu 
1               5                   10                  15      


Gln Asn Phe Thr Ala Ala Ile Pro Thr His His Cys Arg Pro Pro Ala 
            20                  25                  30          


Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu Val Trp Leu Pro Arg 
        35                  40                  45              


Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg Phe Thr Ser Pro Gln 
    50                  55                  60                  


Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala Asn Gly Thr Gly Ala 
65                  70                  75                  80  


Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp Asn Ser Thr Phe Pro 
                85                  90                  95      


Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys Ser His Arg Ala Leu 
            100                 105                 110         


Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly Val Leu Leu Gly Ala 
        115                 120                 125             


Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly Arg Arg Lys Val Leu 
    130                 135                 140                 


Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly Thr Cys Ala Ala Phe 
145                 150                 155                 160 


Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg Leu Leu Ser Gly Met 
                165                 170                 175     


Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr Leu Asn Val Glu Trp 
            180                 185                 190         


Met Pro Ile His Thr Arg Ala Cys Val Gly Thr Leu Ile Gly Tyr Val 
        195                 200                 205             


Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val Ala Tyr Ala Val Pro 
    210                 215                 220                 


His Trp Arg His Leu Gln Leu Leu Val Ser Ala Pro Phe Phe Ala Phe 
225                 230                 235                 240 


Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala Arg Trp His Ser Ser 
                245                 250                 255     


Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu Gln Arg Val Ala Arg 
            260                 265                 270         


Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu Ser Met Glu Val Leu 
        275                 280                 285             


Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly Lys Gly Gln Ala Ser 
    290                 295                 300                 


Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg His Leu Phe Leu Cys 
305                 310                 315                 320 


Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala Tyr Tyr Gly Leu Val 
                325                 330                 335     


Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr Leu Ile Gln Val Ile 
            340                 345                 350         


Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val Gly Phe Leu Val Ile 
        355                 360                 365             


Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala Ala Leu Leu Leu Ala 
    370                 375                 380                 


Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro Gln Asp Gln Ser Ile 
385                 390                 395                 400 


Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly Cys Leu Ala Ala Ser 
                405                 410                 415     


Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu Tyr Pro Thr Met Ile 
            420                 425                 430         


Arg Gln Thr Gly Met Gly Met Gly Ser Thr Met Ala Arg Val Gly Ser 
        435                 440                 445             


Ile Val Ser Pro Leu Val Ser Met Thr Ala Glu Leu Tyr Pro Ser Met 
    450                 455                 460                 


Pro Leu Phe Ile Tyr Gly Ala Val Pro Val Ala Ala Ser Ala Val Thr 
465                 470                 475                 480 


Val Leu Leu Pro Glu Thr Leu Gly Gln Pro Leu Pro Asp Thr Val Gln 
                485                 490                 495     


Asp Leu Glu Ser Arg Lys Gly Lys Gln Thr Arg Gln Gln Gln Glu His 
            500                 505                 510         


Gln Lys Tyr Met Val Pro Leu Gln Ala Ser Ala Gln Glu Lys Asn Gly 
        515                 520                 525             


Leu 
    


<210>  1185
<211>  2194
<212>  DNA
<213>  Homosapiens

<400>  1185
aaaaactgcc catgcaaggg tcaggtctcc agcagaccct gaaagctgag ctgccctgac     60

ccccaaagtg aggagaagct gcaagggaaa agggagggac agatcaggga gaccggggaa    120

gaaggaggag cagccaagga ggctgctgtc cccccacaga gcagctcgga ctcagctccc    180

ggagcaaccc agctgcggag gcaacggcag tgctgctcct ccagcgaagg acagcaggca    240

ggcagacaga cagaggtcct gggactggaa ggcctcagcc cccagccact gggctgggcc    300

tggcccaatg gcctttaatg acctcctgca gcaggtgggg ggtgtcggcc gcttccagca    360

gatccaggtc accctggtgg tcctccccct gctcctgatg gcttctcaca acaccctgca    420

gaacttcact gctgccatcc ctacccacca ctgccgcccg cctgccgatg ccaacctcag    480

caagaacggg gggctggagg tctggctgcc ccgggacagg caggggcagc ctgagtcctg    540

cctccgcttc acctccccgc agtggggact gccctttctc aatggcacag aagccaatgg    600

cacaggggcc acagagccct gcaccgatgg ctggatctat gacaacagca ccttcccatc    660

taccatcgtg actgagtggg accttgtgtg ctctcacagg gccctacgcc agctggccca    720

gtccttgtac atggtggggg tgctgctcgg agccatggtg ttcggctacc ttgcagacag    780

gctaggccgc cggaaggtac tcatcttgaa ctacctgcag acagctgtgt cagggacctg    840

cgcagccttc gcacccaact tccccatcta ctgcgccttc cggctcctct cgggcatggc    900

tctggctggc atctccctca actgcatgac actgaatgtg gagtggatgc ccattcacac    960

acgggcctgc gtgggcacct tgattggcta tgtctacagc ctgggccagt tcctcctggc   1020

tggtgtggcc tacgctgtgc cccactggcg ccacctgcag ctactggtct ctgcgccttt   1080

ttttgccttc ttcatctact cctggttctt cattgagtcg gcccgctggc actcctcctc   1140

cgggaggctg gacctcaccc tgagggccct gcagagagtc gcccggatca atgggaagcg   1200

ggaagaagga gccaaattga gtatggaggt actccgggcc agtctgcaga aggagctgac   1260

catgggcaaa ggccaggcat cggccatgga gctgctgcgc tgccccaccc tccgccacct   1320

cttcctctgc ctctccatgc tgtggtttgc cactagcttt gcatactatg ggctggtcat   1380

ggacctgcag ggctttggag tcagcatcta cctaatccag gtgatctttg gtgctgtgga   1440

cctgcctgcc aagcttgtgg gcttccttgt catcaactcc ctgggtcgcc ggcctgccca   1500

gatggctgca ctgctgctgg caggcatctg catcctgctc aatggggtga taccccagga   1560

ccagtccatt gtccgaacct ctcttgctgt gctggggaag ggttgtctgg ctgcctcctt   1620

caactgcatc ttcctgtata ctggggaact gtatcccaca atgatccggc agacaggcat   1680

gggaatgggc agcaccatgg cccgagtggg cagcatcgtg agcccactgg tgagcatgac   1740

tgccgagctc tacccctcca tgcctctctt catctacggt gctgttcctg tggccgccag   1800

cgctgtcact gtcctcctgc cagagaccct gggccagcca ctgccagaca cggtgcagga   1860

cctggagagc aggaaaggga aacagacgcg acagcaacaa gagcaccaga agtatatggt   1920

cccactgcag gcctcagcac aagagaagaa tggactctga ggactgagaa ggggccttac   1980

agaaccctaa agggagggaa ggtcctacag gtctccggcc acccacacaa ggaggaggaa   2040

gaggaaatgg tgacccaagt gtgggggttg tggttcagga aagcatcttc ccaggggtcc   2100

acctcccttt ataaacccca ccagaaccac atcattaaaa ggtttgactg cgcaccaaaa   2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               2194


<210>  1186
<211>  550
<212>  PRT
<213>  Homosapiens

<400>  1186

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Gln Thr Gly Met Gly Met Gly Ser Thr Met 
    450                 455                 460                 


Ala Arg Val Gly Ser Ile Val Ser Pro Leu Val Ser Met Thr Ala Glu 
465                 470                 475                 480 


Leu Tyr Pro Ser Met Pro Leu Phe Ile Tyr Gly Ala Val Pro Val Ala 
                485                 490                 495     


Ala Ser Ala Val Thr Val Leu Leu Pro Glu Thr Leu Gly Gln Pro Leu 
            500                 505                 510         


Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Lys Gly Lys Gln Thr Arg 
        515                 520                 525             


Gln Gln Gln Glu His Gln Lys Tyr Met Val Pro Leu Gln Ala Ser Ala 
    530                 535                 540                 


Gln Glu Lys Asn Gly Leu 
545                 550 


<210>  1187
<211>  2025
<212>  DNA
<213>  Homosapiens

<400>  1187
aaaaactgcc catgcaaggg tcaggtctcc agcagaccct gaaagctgag ctgccctgac     60

ccccaaagtg aggagaagct gcaagggaaa agggagggac agatcaggga gaccggggaa    120

gaaggaggag cagccaagga ggctgctgtc cccccacaga gcagctcgga ctcagctccc    180

ggagcaaccc agctgcggag gcaacggcag tgctgctcct ccagcgaagg acagcaggca    240

ggcagacaga cagaggtcct gggactggaa ggcctcagcc cccagccact gggctgggcc    300

tggcccaatg gcctttaatg acctcctgca gcaggtgggg ggtgtcggcc gcttccagca    360

gatccaggtc accctggtgg tcctccccct gctcctgatg gcttctcaca acaccctgca    420

gaacttcact gctgccatcc ctacccacca ctgccgcccg cctgccgatg ccaacctcag    480

caagaacggg gggctggagg tctggctgcc ccgggacagg caggggcagc ctgagtcctg    540

cctccgcttc acctccccgc agtggggact gccctttctc aatggcacag aagccaatgg    600

cacaggggcc acagagccct gcaccgatgg ctggatctat gacaacagca ccttcccatc    660

taccatcgtg actgagtggg accttgtgtg ctctcacagg gccctacgcc agctggccca    720

gtccttgtac atggtggggg tgctgctcgg agccatggtg ttcggctacc ttgcagacag    780

gctaggccgc cggaaggtac tcatcttgaa ctacctgcag acagctgtgt cagggacctg    840

cgcagccttc gcacccaact tccccatcta ctgcgccttc cggctcctct cgggcatggc    900

tctggctggc atctccctca actgcatgac actgaatgtg gagtggatgc ccattcacac    960

acgggcctgc gtgggcacct tgattggcta tgtctacagc ctgggccagt tcctcctggc   1020

tggtgtggcc tacgctgtgc cccactggcg ccacctgcag ctactggtct ctgcgccttt   1080

ttttgccttc ttcatctact cctggttctt cattgagtcg gcccgctggc actcctcctc   1140

cgggaggctg gacctcaccc tgagggccct gcagagagtc gcccggatca atgggaagcg   1200

ggaagaagga gccaaattga gtatggaggt actccgggcc agtctgcaga aggagctgac   1260

catgggcaaa ggccaggcat cggccatgga gctgctgcgc tgccccaccc tccgccacct   1320

cttcctctgc ctctccatgc tgtggtttgc cactagcttt gcatactatg ggctggtcat   1380

ggacctgcag ggctttggag tcagcatcta cctaatccag gtgatctttg gtgctgtgga   1440

cctgcctgcc aagcttgtgg gcttccttgt catcaactcc ctgggtcgcc ggcctgccca   1500

gatggctgca ctgctgctgg caggcatctg catcctgctc aatggggtga taccccagga   1560

ccagtccatt gtccgaacct ctcttgctgt gctggggaag ggttgtctgg ctgcctcctt   1620

caactgcatc ttcctgtata ctggggaact gtatcccaca atgatccgcg ctgtcactgt   1680

cctcctgcca gagaccctgg gccagccact gccagacacg gtgcaggacc tggagagcag   1740

gaaagggaaa cagacgcgac agcaacaaga gcaccagaag tatatggtcc cactgcaggc   1800

ctcagcacaa gagaagaatg gactctgagg actgagaagg ggccttacag aaccctaaag   1860

ggagggaagg tcctacaggt ctccggccac ccacacaagg aggaggaaga ggaaatggtg   1920

acccaagtgt gggggttgtg gttcaggaaa gcatcttccc aggggtccac ctccctttat   1980

aaaccccacc agaaccacat cattaaaagg tttgactgcg cacca                   2025


<210>  1188
<211>  506
<212>  PRT
<213>  Homosapiens

<400>  1188

Met Ala Phe Asn Asp Leu Leu Gln Gln Val Gly Gly Val Gly Arg Phe 
1               5                   10                  15      


Gln Gln Ile Gln Val Thr Leu Val Val Leu Pro Leu Leu Leu Met Ala 
            20                  25                  30          


Ser His Asn Thr Leu Gln Asn Phe Thr Ala Ala Ile Pro Thr His His 
        35                  40                  45              


Cys Arg Pro Pro Ala Asp Ala Asn Leu Ser Lys Asn Gly Gly Leu Glu 
    50                  55                  60                  


Val Trp Leu Pro Arg Asp Arg Gln Gly Gln Pro Glu Ser Cys Leu Arg 
65                  70                  75                  80  


Phe Thr Ser Pro Gln Trp Gly Leu Pro Phe Leu Asn Gly Thr Glu Ala 
                85                  90                  95      


Asn Gly Thr Gly Ala Thr Glu Pro Cys Thr Asp Gly Trp Ile Tyr Asp 
            100                 105                 110         


Asn Ser Thr Phe Pro Ser Thr Ile Val Thr Glu Trp Asp Leu Val Cys 
        115                 120                 125             


Ser His Arg Ala Leu Arg Gln Leu Ala Gln Ser Leu Tyr Met Val Gly 
    130                 135                 140                 


Val Leu Leu Gly Ala Met Val Phe Gly Tyr Leu Ala Asp Arg Leu Gly 
145                 150                 155                 160 


Arg Arg Lys Val Leu Ile Leu Asn Tyr Leu Gln Thr Ala Val Ser Gly 
                165                 170                 175     


Thr Cys Ala Ala Phe Ala Pro Asn Phe Pro Ile Tyr Cys Ala Phe Arg 
            180                 185                 190         


Leu Leu Ser Gly Met Ala Leu Ala Gly Ile Ser Leu Asn Cys Met Thr 
        195                 200                 205             


Leu Asn Val Glu Trp Met Pro Ile His Thr Arg Ala Cys Val Gly Thr 
    210                 215                 220                 


Leu Ile Gly Tyr Val Tyr Ser Leu Gly Gln Phe Leu Leu Ala Gly Val 
225                 230                 235                 240 


Ala Tyr Ala Val Pro His Trp Arg His Leu Gln Leu Leu Val Ser Ala 
                245                 250                 255     


Pro Phe Phe Ala Phe Phe Ile Tyr Ser Trp Phe Phe Ile Glu Ser Ala 
            260                 265                 270         


Arg Trp His Ser Ser Ser Gly Arg Leu Asp Leu Thr Leu Arg Ala Leu 
        275                 280                 285             


Gln Arg Val Ala Arg Ile Asn Gly Lys Arg Glu Glu Gly Ala Lys Leu 
    290                 295                 300                 


Ser Met Glu Val Leu Arg Ala Ser Leu Gln Lys Glu Leu Thr Met Gly 
305                 310                 315                 320 


Lys Gly Gln Ala Ser Ala Met Glu Leu Leu Arg Cys Pro Thr Leu Arg 
                325                 330                 335     


His Leu Phe Leu Cys Leu Ser Met Leu Trp Phe Ala Thr Ser Phe Ala 
            340                 345                 350         


Tyr Tyr Gly Leu Val Met Asp Leu Gln Gly Phe Gly Val Ser Ile Tyr 
        355                 360                 365             


Leu Ile Gln Val Ile Phe Gly Ala Val Asp Leu Pro Ala Lys Leu Val 
    370                 375                 380                 


Gly Phe Leu Val Ile Asn Ser Leu Gly Arg Arg Pro Ala Gln Met Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Ala Gly Ile Cys Ile Leu Leu Asn Gly Val Ile Pro 
                405                 410                 415     


Gln Asp Gln Ser Ile Val Arg Thr Ser Leu Ala Val Leu Gly Lys Gly 
            420                 425                 430         


Cys Leu Ala Ala Ser Phe Asn Cys Ile Phe Leu Tyr Thr Gly Glu Leu 
        435                 440                 445             


Tyr Pro Thr Met Ile Arg Ala Val Thr Val Leu Leu Pro Glu Thr Leu 
    450                 455                 460                 


Gly Gln Pro Leu Pro Asp Thr Val Gln Asp Leu Glu Ser Arg Lys Gly 
465                 470                 475                 480 


Lys Gln Thr Arg Gln Gln Gln Glu His Gln Lys Tyr Met Val Pro Leu 
                485                 490                 495     


Gln Ala Ser Ala Gln Glu Lys Asn Gly Leu 
            500                 505     


<210>  1189
<211>  2207
<212>  DNA
<213>  Homosapiens

<400>  1189
agcttgttag agctgagctg ccctactaca gcagctgccg gcccctagga cagagcaggg     60

acctcaacta cactgatcac cagccccatc ggatccagac ccggccacca gctctggctc    120

gtcttgcccc agtgccatga ccttctcgga gatcctggac cgtgtgggaa gcatgggcca    180

tttccagttc ctgcatgtag ccatactggg cctcccgatc ctcaacatgg ccaaccacaa    240

cctgctgcag atcttcacag ccgccacccc tgtccaccac tgtcgcccgc cccacaatgc    300

ctccacaggg ccttgggtgc tccccatggg cccaaatggg aagcctgaga ggtgcctccg    360

ttttgtacat ccgcccaatg ccagcctgcc caatgacacc cagagggcca tggagccatg    420

cctggatggc tgggtctaca acagcaccaa ggactccatt gtgacagagt gggacttggt    480

gtgcaactcc aacaaactga aggagatggc ccagtctatc ttcatggcag gtatactgat    540

tggagggctc gtgcttggag acctgtctga caggtttggc cgcaggccca tcctgacctg    600

cagctacctg ctgctggcag ccagcggctc cggtgcagcc ttcagcccca ccttccccat    660

ctacatggtc ttccgcttcc tgtgtggctt tggcatctca ggcattaccc tgagcaccgt    720

catcttgaat gtggaatggg tgcctacccg gatgcgggcc atcatgtcga cagcactcgg    780

gtactgctac acctttggcc agttcattct gcccggcctg gcctacgcca tcccccagtg    840

gcgttggctg cagttaactg tgtccattcc cttcttcgtc ttcttcctat catcctggtg    900

gacaccagag tccatacgct ggttggtctt gtctggaaag tcctcgaagg ccctgaagat    960

actccggcgg gtggctgtct tcaatggcaa gaaggaagag ggagaaaggc tcagcttgga   1020

ggagctcaaa ctcaacctgc agaaggagat ctccttggcc aaggccaagt acaccgcaag   1080

tgacctgttc cggataccca tgctgcgccg catgaccttc tgtctttccc tggcctggtt   1140

tgctaccggt tttgcctact atagtttggc tatgggtgtg gaagaatttg gagtcaacct   1200

ctacatcctc cagatcatct ttggtggggt cgatgtccca gccaagttca tcaccatcct   1260

ctccttaagc tacctgggcc ggcataccac tcaggccgct gccctgctcc tggcaggagg   1320

ggccatcttg gctctcacct ttgtgccctt ggacttgcag accgtgagga cagtattggc   1380

tgtgtttggg aagggatgcc tatccagctc cttcagctgc ctcttcctct acacaagtga   1440

attatacccc acagtcatca ggcaaacagg tatgggcgta agtaacctgt ggacccgcgt   1500

gggaagcatg gtgtccccgc tggtgaaaat cacgggtgag gtacagccct tcatccccaa   1560

tatcatctac gggatcaccg ccctcctcgg gggcagtgct gccctcttcc tgcctgagac   1620

cctgaatcag cccttgccag agactatcga agacctggaa aactggtccc tgcgggcaaa   1680

gaagccaaag caggagccag aggtggaaaa ggcctcccag aggatccctc tacagcctca   1740

cggaccaggc ctgggctcca gctgaggaca acggaacccc ctttccctgc cctccagaga   1800

ctgatcctag ccaggcacct taggagtata gggaggcccc atataggtcc atcctcctag   1860

gatgaagcct tctgagagct tggtgaaggt gtctccatca ccaccaccag agcctcctgc   1920

ccagccctgg ccagttcaaa ggttcagcca tccctgccct tgttctccct gcaacccagg   1980

ccctgccatt cttctgtcta gcccttcccc actggccacc ttcccccact gtcccggtcc   2040

tcttcccctg aggtcccctg atatcccctg gctcagtcct aacaagactg agtcttaaca   2100

agatgagaag tcctcccctt cttgcctccc acacttttct ttgatgggag gtttcaataa   2160

acagcgataa gaactctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2207


<210>  1190
<211>  542
<212>  PRT
<213>  Homosapiens

<400>  1190

Met Thr Phe Ser Glu Ile Leu Asp Arg Val Gly Ser Met Gly His Phe 
1               5                   10                  15      


Gln Phe Leu His Val Ala Ile Leu Gly Leu Pro Ile Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Leu Leu Gln Ile Phe Thr Ala Ala Thr Pro Val His His 
        35                  40                  45              


Cys Arg Pro Pro His Asn Ala Ser Thr Gly Pro Trp Val Leu Pro Met 
    50                  55                  60                  


Gly Pro Asn Gly Lys Pro Glu Arg Cys Leu Arg Phe Val His Pro Pro 
65                  70                  75                  80  


Asn Ala Ser Leu Pro Asn Asp Thr Gln Arg Ala Met Glu Pro Cys Leu 
                85                  90                  95      


Asp Gly Trp Val Tyr Asn Ser Thr Lys Asp Ser Ile Val Thr Glu Trp 
            100                 105                 110         


Asp Leu Val Cys Asn Ser Asn Lys Leu Lys Glu Met Ala Gln Ser Ile 
        115                 120                 125             


Phe Met Ala Gly Ile Leu Ile Gly Gly Leu Val Leu Gly Asp Leu Ser 
    130                 135                 140                 


Asp Arg Phe Gly Arg Arg Pro Ile Leu Thr Cys Ser Tyr Leu Leu Leu 
145                 150                 155                 160 


Ala Ala Ser Gly Ser Gly Ala Ala Phe Ser Pro Thr Phe Pro Ile Tyr 
                165                 170                 175     


Met Val Phe Arg Phe Leu Cys Gly Phe Gly Ile Ser Gly Ile Thr Leu 
            180                 185                 190         


Ser Thr Val Ile Leu Asn Val Glu Trp Val Pro Thr Arg Met Arg Ala 
        195                 200                 205             


Ile Met Ser Thr Ala Leu Gly Tyr Cys Tyr Thr Phe Gly Gln Phe Ile 
    210                 215                 220                 


Leu Pro Gly Leu Ala Tyr Ala Ile Pro Gln Trp Arg Trp Leu Gln Leu 
225                 230                 235                 240 


Thr Val Ser Ile Pro Phe Phe Val Phe Phe Leu Ser Ser Trp Trp Thr 
                245                 250                 255     


Pro Glu Ser Ile Arg Trp Leu Val Leu Ser Gly Lys Ser Ser Lys Ala 
            260                 265                 270         


Leu Lys Ile Leu Arg Arg Val Ala Val Phe Asn Gly Lys Lys Glu Glu 
        275                 280                 285             


Gly Glu Arg Leu Ser Leu Glu Glu Leu Lys Leu Asn Leu Gln Lys Glu 
    290                 295                 300                 


Ile Ser Leu Ala Lys Ala Lys Tyr Thr Ala Ser Asp Leu Phe Arg Ile 
305                 310                 315                 320 


Pro Met Leu Arg Arg Met Thr Phe Cys Leu Ser Leu Ala Trp Phe Ala 
                325                 330                 335     


Thr Gly Phe Ala Tyr Tyr Ser Leu Ala Met Gly Val Glu Glu Phe Gly 
            340                 345                 350         


Val Asn Leu Tyr Ile Leu Gln Ile Ile Phe Gly Gly Val Asp Val Pro 
        355                 360                 365             


Ala Lys Phe Ile Thr Ile Leu Ser Leu Ser Tyr Leu Gly Arg His Thr 
    370                 375                 380                 


Thr Gln Ala Ala Ala Leu Leu Leu Ala Gly Gly Ala Ile Leu Ala Leu 
385                 390                 395                 400 


Thr Phe Val Pro Leu Asp Leu Gln Thr Val Arg Thr Val Leu Ala Val 
                405                 410                 415     


Phe Gly Lys Gly Cys Leu Ser Ser Ser Phe Ser Cys Leu Phe Leu Tyr 
            420                 425                 430         


Thr Ser Glu Leu Tyr Pro Thr Val Ile Arg Gln Thr Gly Met Gly Val 
        435                 440                 445             


Ser Asn Leu Trp Thr Arg Val Gly Ser Met Val Ser Pro Leu Val Lys 
    450                 455                 460                 


Ile Thr Gly Glu Val Gln Pro Phe Ile Pro Asn Ile Ile Tyr Gly Ile 
465                 470                 475                 480 


Thr Ala Leu Leu Gly Gly Ser Ala Ala Leu Phe Leu Pro Glu Thr Leu 
                485                 490                 495     


Asn Gln Pro Leu Pro Glu Thr Ile Glu Asp Leu Glu Asn Trp Ser Leu 
            500                 505                 510         


Arg Ala Lys Lys Pro Lys Gln Glu Pro Glu Val Glu Lys Ala Ser Gln 
        515                 520                 525             


Arg Ile Pro Leu Gln Pro His Gly Pro Gly Leu Gly Ser Ser 
    530                 535                 540         


<210>  1191
<211>  972
<212>  DNA
<213>  Homosapiens

<400>  1191
atgctgtctc tagcaccaag aggtgtggac cccaagttcc tgaagaatat gcgctttgcc     60

aagaagcaca tcaagaaggg cctaaagaag atgcaggtca acaatgccaa ggccatgagt    120

gcacatgcca aggctatcaa ggccctcata aagcccaagg aagttaagct caagatccca    180

aagagtgggc tcgggcagtg ccagccaaag gccaagggtc aaaccaaggc ccaggctgca    240

gctccagctt cagttccagc tcaggctccc aaaggtgccc aagcccctac aaagacttca    300

gagtggatat ctctgtctac caagcttgtg agatccacca tgaagaagga gttggatgca    360

gtccgaatta aaacatccat tttttccctg ttccgtgcac ccaaattgcg aatgagagtc    420

ttcggcctgt gctttgtgag attcgcaatc actgtaccct tttatggcct gatactcaac    480

ttgcagcact tagggagcaa tgtctccctg ttccagattc tctgtggagc tgtcacattc    540

acagccagat gtgtttccct tttgacactg aatcatatgg gtcgtcgaat aagccagata    600

ttgttcacgt tcccggtggg acttttcatt ctggtcaaca cctttttgcc ccaagaaatg    660

cagatcctgc gtgtggtttt agcaactttg ggaattggta gtgtttctgc tgctagcaac    720

agtgcttctg tccaccacaa cgagctcgtc cccaccatat tgaggtcaac agttgcagga    780

atcaatgcag tgtccggtag gactggggca gcactggctc ctctgttgat gaccttaatg    840

gcgtattctc cccacctacc ctggatttcc tatggagtct tccccatcct tgctgtccct    900

gttatcctcc tccttccaga aaccagggat ctacctcttc ctaacaccat ccaggatgtg    960

gaaaatgagt ga                                                        972


<210>  1192
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  1192

Met Leu Ser Leu Ala Pro Arg Gly Val Asp Pro Lys Phe Leu Lys Asn 
1               5                   10                  15      


Met Arg Phe Ala Lys Lys His Ile Lys Lys Gly Leu Lys Lys Met Gln 
            20                  25                  30          


Val Asn Asn Ala Lys Ala Met Ser Ala His Ala Lys Ala Ile Lys Ala 
        35                  40                  45              


Leu Ile Lys Pro Lys Glu Val Lys Leu Lys Ile Pro Lys Ser Gly Leu 
    50                  55                  60                  


Gly Gln Cys Gln Pro Lys Ala Lys Gly Gln Thr Lys Ala Gln Ala Ala 
65                  70                  75                  80  


Ala Pro Ala Ser Val Pro Ala Gln Ala Pro Lys Gly Ala Gln Ala Pro 
                85                  90                  95      


Thr Lys Thr Ser Glu Trp Ile Ser Leu Ser Thr Lys Leu Val Arg Ser 
            100                 105                 110         


Thr Met Lys Lys Glu Leu Asp Ala Val Arg Ile Lys Thr Ser Ile Phe 
        115                 120                 125             


Ser Leu Phe Arg Ala Pro Lys Leu Arg Met Arg Val Phe Gly Leu Cys 
    130                 135                 140                 


Phe Val Arg Phe Ala Ile Thr Val Pro Phe Tyr Gly Leu Ile Leu Asn 
145                 150                 155                 160 


Leu Gln His Leu Gly Ser Asn Val Ser Leu Phe Gln Ile Leu Cys Gly 
                165                 170                 175     


Ala Val Thr Phe Thr Ala Arg Cys Val Ser Leu Leu Thr Leu Asn His 
            180                 185                 190         


Met Gly Arg Arg Ile Ser Gln Ile Leu Phe Thr Phe Pro Val Gly Leu 
        195                 200                 205             


Phe Ile Leu Val Asn Thr Phe Leu Pro Gln Glu Met Gln Ile Leu Arg 
    210                 215                 220                 


Val Val Leu Ala Thr Leu Gly Ile Gly Ser Val Ser Ala Ala Ser Asn 
225                 230                 235                 240 


Ser Ala Ser Val His His Asn Glu Leu Val Pro Thr Ile Leu Arg Ser 
                245                 250                 255     


Thr Val Ala Gly Ile Asn Ala Val Ser Gly Arg Thr Gly Ala Ala Leu 
            260                 265                 270         


Ala Pro Leu Leu Met Thr Leu Met Ala Tyr Ser Pro His Leu Pro Trp 
        275                 280                 285             


Ile Ser Tyr Gly Val Phe Pro Ile Leu Ala Val Pro Val Ile Leu Leu 
    290                 295                 300                 


Leu Pro Glu Thr Arg Asp Leu Pro Leu Pro Asn Thr Ile Gln Asp Val 
305                 310                 315                 320 


Glu Asn Glu 
            


<210>  1193
<211>  2958
<212>  DNA
<213>  Homosapiens

<400>  1193
aacgcggcct gaattcccgg cgccggcccc agctcctctg ccgctgccgc catgctcgac     60

ttcttcacca ttttctccaa gggcgggctt gtgctctggt gcttccaggg cgttagcgac    120

tcatgcaccg gacccgttaa cgcgttgatt cgttccgtgc tgctgcagga acggggaggt    180

aacaactcct tcacccatga ggcactcaca ctcaagtata aactggacaa ccagtttgag    240

ctggtgtttg tggttggttt tcagaagatc ctgacactga catatgtaga caaattgata    300

gatgacgtgc atcggctgtt tcgggacaag taccgcacag agatccaaca gcaaagtgct    360

ttaagtttat taaatggcac ttttgatttc caaaatgact tcctgcggct ccttcgtgaa    420

gcagaggaga gcagtaagat ccgtgctccc actaccatga agaaatttga agattctgaa    480

aaggccaaga aacctgtgag gtccatgatt gagacacggg gggaaaagcc caaggaaaaa    540

gcaaagaata gcaaaaaaaa gggggccaag aaggaaggtt ctgatggtcc tttggctacc    600

agcaaaccag tccctgcaga aaagtcaggt cttccagtgg gtcctgagaa cggagtagaa    660

ctttccaaag aggagctgat ccgcaggaag cgcgaggagt tcattcagaa gcatgggagg    720

ggtatggaga agtccaacaa gtccacgaag tcagatgctc caaaggagaa gggcaaaaaa    780

gcaccccggg tgtgggaact gggtggctgt gctaacaaag aagtgttgga ttacagtact    840

cccaccacca atggaacccc tgaggctgcc ttgtctgagg acatcaacct gattcgaggg    900

actgggtctg gggggcagct tcaggatctg gactgcagca gctctgatga cgaaggggct    960

gctcaaaact ctaccaaacc tagtgcgacc aagggaacac tgggtggcat gtttggtatg   1020

ctgaagggcc ttgtgggttc aaagagcttg agtcgtgaag acatggaatc tgtgctggac   1080

aagatgcgtg atcatctcat tgctaagaac gtggctgcag acattgccgt ccagctctgt   1140

gaatctgttg ccaacaagtt ggaagggaag gtgatgggga cgttcagcac ggtgacttcc   1200

acagtaaagc aagccctaca ggagtccctg gtgcagattc tgcagccaca gcgtcgtgta   1260

gacatgctcc gggacatcat ggatgcccag cgtcgccagc gcccttatgt cgtcaccttc   1320

tgcggcgtta atggagtggg gaaatctact aatcttgcca agatttcctt ctggttgtta   1380

gagaatggct tcagtgtcct cattgctgcc tgtgatacat ttcgtgctgg ggccgtggag   1440

cagctgcgta cacacacccg gcgtttgagt gccctacacc ctccagagaa gcatggtggc   1500

cgcaccatgg tgcagttgtt tgaaaagggc tatggcaagg atgctgctgg cattgccatg   1560

gaagccattg cttttgcacg taaccaaggc tttgacgtgg tgctggtgga cacggcaggc   1620

cgcatgcaag acaatgcccc tctgatgact gccctggcca aactcattac tgtcaataca   1680

cctgatttgg tgctgtttgt aggagaagcc ttagtaggca atgaagccgt ggaccagctg   1740

gtcaagttca acagagcctt ggctgaccat tctatggctc agacacctcg gctcattgat   1800

ggcattgttc ttaccaaatt tgataccatt gatgacaagg tgggagctgc tatttctatg   1860

acgtacatca caagcaaacc catcgtcttt gtgggcaccg gccagaccta ctgtgaccta   1920

cgcagcctca atgccaaggc tgtggtggct gccctcatga aggcttaacg tggctcttgc   1980

ccaataccaa atcgccgctt tccccacaag cccttcttcc tgtatcaaga atgtgcttta   2040

gagtatgtga gcaacctgtc ttcagtgtag tacaaaggca gagtgagggg gcttgtggct   2100

ccttccaacc ccactccccg ttcagcacag ccgccatttg caaggaaggc ctaatcatgt   2160

tacaatcact gcccactgac cctctcccag cgggcctccc ccttcctact caggcacccc   2220

cttcactctg cctacagact cagtcttatt acagctttga ccaatggttg gaacccaaca   2280

ccagagcttt gctaataatt agtgtggtca agagccgtct gagcctaatg agtcccagct   2340

gcattaggtt aagagactct tccagagcca gcgccaggtc ttgaatggca cctctcccta   2400

ggatacacag cctgcaggtc cccaggacct ggatgacacc cgcctcactg tggcagtgta   2460

ttgcctgtta attgctgcta attctaattc tgatgatgac tcctactcca ttgtttaccc   2520

caaagcatca gctaggctgg agtgatttgt tacaaatgag caaaagatga gtccttgctt   2580

ccctcagaaa taaaagtagc tcagctgcag cgttgcattg ggcttcttgg cctcccaact   2640

cttcccactc ccagaatcca gaagtaagct ctgcatgttc cccttcctgg gaggaaacca   2700

attgtcagaa ggatgtatga tgaccccctc ccctcccatc cttcacctcc taagcagtcc   2760

tggcttttcc tcatcactcc cctctacagt gcctggtaga caagtgctac attgaagaac   2820

acaaacctct tgttaagact tgtcctgtag cttgatatta cagatgtgct attagtgcaa   2880

taaggtgaag gctgtctgcc cagagaaata agtaatttat ataagaaaat aaatttcata   2940

aataaaaaaa aaaaaaaa                                                 2958


<210>  1194
<211>  638
<212>  PRT
<213>  Homosapiens

<400>  1194

Met Leu Asp Phe Phe Thr Ile Phe Ser Lys Gly Gly Leu Val Leu Trp 
1               5                   10                  15      


Cys Phe Gln Gly Val Ser Asp Ser Cys Thr Gly Pro Val Asn Ala Leu 
            20                  25                  30          


Ile Arg Ser Val Leu Leu Gln Glu Arg Gly Gly Asn Asn Ser Phe Thr 
        35                  40                  45              


His Glu Ala Leu Thr Leu Lys Tyr Lys Leu Asp Asn Gln Phe Glu Leu 
    50                  55                  60                  


Val Phe Val Val Gly Phe Gln Lys Ile Leu Thr Leu Thr Tyr Val Asp 
65                  70                  75                  80  


Lys Leu Ile Asp Asp Val His Arg Leu Phe Arg Asp Lys Tyr Arg Thr 
                85                  90                  95      


Glu Ile Gln Gln Gln Ser Ala Leu Ser Leu Leu Asn Gly Thr Phe Asp 
            100                 105                 110         


Phe Gln Asn Asp Phe Leu Arg Leu Leu Arg Glu Ala Glu Glu Ser Ser 
        115                 120                 125             


Lys Ile Arg Ala Pro Thr Thr Met Lys Lys Phe Glu Asp Ser Glu Lys 
    130                 135                 140                 


Ala Lys Lys Pro Val Arg Ser Met Ile Glu Thr Arg Gly Glu Lys Pro 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Asn Ser Lys Lys Lys Gly Ala Lys Lys Glu Gly 
                165                 170                 175     


Ser Asp Gly Pro Leu Ala Thr Ser Lys Pro Val Pro Ala Glu Lys Ser 
            180                 185                 190         


Gly Leu Pro Val Gly Pro Glu Asn Gly Val Glu Leu Ser Lys Glu Glu 
        195                 200                 205             


Leu Ile Arg Arg Lys Arg Glu Glu Phe Ile Gln Lys His Gly Arg Gly 
    210                 215                 220                 


Met Glu Lys Ser Asn Lys Ser Thr Lys Ser Asp Ala Pro Lys Glu Lys 
225                 230                 235                 240 


Gly Lys Lys Ala Pro Arg Val Trp Glu Leu Gly Gly Cys Ala Asn Lys 
                245                 250                 255     


Glu Val Leu Asp Tyr Ser Thr Pro Thr Thr Asn Gly Thr Pro Glu Ala 
            260                 265                 270         


Ala Leu Ser Glu Asp Ile Asn Leu Ile Arg Gly Thr Gly Ser Gly Gly 
        275                 280                 285             


Gln Leu Gln Asp Leu Asp Cys Ser Ser Ser Asp Asp Glu Gly Ala Ala 
    290                 295                 300                 


Gln Asn Ser Thr Lys Pro Ser Ala Thr Lys Gly Thr Leu Gly Gly Met 
305                 310                 315                 320 


Phe Gly Met Leu Lys Gly Leu Val Gly Ser Lys Ser Leu Ser Arg Glu 
                325                 330                 335     


Asp Met Glu Ser Val Leu Asp Lys Met Arg Asp His Leu Ile Ala Lys 
            340                 345                 350         


Asn Val Ala Ala Asp Ile Ala Val Gln Leu Cys Glu Ser Val Ala Asn 
        355                 360                 365             


Lys Leu Glu Gly Lys Val Met Gly Thr Phe Ser Thr Val Thr Ser Thr 
    370                 375                 380                 


Val Lys Gln Ala Leu Gln Glu Ser Leu Val Gln Ile Leu Gln Pro Gln 
385                 390                 395                 400 


Arg Arg Val Asp Met Leu Arg Asp Ile Met Asp Ala Gln Arg Arg Gln 
                405                 410                 415     


Arg Pro Tyr Val Val Thr Phe Cys Gly Val Asn Gly Val Gly Lys Ser 
            420                 425                 430         


Thr Asn Leu Ala Lys Ile Ser Phe Trp Leu Leu Glu Asn Gly Phe Ser 
        435                 440                 445             


Val Leu Ile Ala Ala Cys Asp Thr Phe Arg Ala Gly Ala Val Glu Gln 
    450                 455                 460                 


Leu Arg Thr His Thr Arg Arg Leu Ser Ala Leu His Pro Pro Glu Lys 
465                 470                 475                 480 


His Gly Gly Arg Thr Met Val Gln Leu Phe Glu Lys Gly Tyr Gly Lys 
                485                 490                 495     


Asp Ala Ala Gly Ile Ala Met Glu Ala Ile Ala Phe Ala Arg Asn Gln 
            500                 505                 510         


Gly Phe Asp Val Val Leu Val Asp Thr Ala Gly Arg Met Gln Asp Asn 
        515                 520                 525             


Ala Pro Leu Met Thr Ala Leu Ala Lys Leu Ile Thr Val Asn Thr Pro 
    530                 535                 540                 


Asp Leu Val Leu Phe Val Gly Glu Ala Leu Val Gly Asn Glu Ala Val 
545                 550                 555                 560 


Asp Gln Leu Val Lys Phe Asn Arg Ala Leu Ala Asp His Ser Met Ala 
                565                 570                 575     


Gln Thr Pro Arg Leu Ile Asp Gly Ile Val Leu Thr Lys Phe Asp Thr 
            580                 585                 590         


Ile Asp Asp Lys Val Gly Ala Ala Ile Ser Met Thr Tyr Ile Thr Ser 
        595                 600                 605             


Lys Pro Ile Val Phe Val Gly Thr Gly Gln Thr Tyr Cys Asp Leu Arg 
    610                 615                 620                 


Ser Leu Asn Ala Lys Ala Val Val Ala Ala Leu Met Lys Ala 
625                 630                 635             


<210>  1195
<211>  1967
<212>  DNA
<213>  Homosapiens

<400>  1195
agcgaggcag cagtgcagct ttcagagggt ccgggctcag aggggttatg attcggaggg     60

ttctgccgca cggcatgggc cggggcctct tgacccggag gccaggcacg cgcagaggag    120

gcttttctct ggactgggat ggaaaggtgt ctgagattaa gaagaagatc aagtcgatcc    180

tgcctggaag gtcctgtgat ctactgcaag acaccagcca cctgcctccc gagcactcgg    240

atgtggtgat cgtgggaggt ggggtgcttg gcttgtctgt ggcctattgg ctgaagaagc    300

tggagagcag acgaggtgct attcgagtgc tagtggtgga acgggaccac acgtattcac    360

aggcctccac tgggctctca gtaggtggga tttgtcagca gttctcattg cctgagaaca    420

tccagctctc cctcttttca gccagctttc tacggaacat caatgagtac ctggccgtag    480

tcgatgctcc tcccctggac ctccggttca acccctcggg ctacctcttg ctggcttcag    540

aaaaggatgc tgcagccatg gagagcaacg tgaaagtgca gaggcaggag ggagccaaag    600

tttctctgat gtctcctgat cagcttcgga acaagtttcc ctggataaac acagagggag    660

tggctttggc gtcttatggg atggaggacg aaggttggtt tgacccctgg tgtctgctcc    720

aggggcttcg gcgaaaggtc cagtccttgg gagtcctttt ctgccaggga gaggtgacac    780

gttttgtctc ttcatctcaa cgcatgttga ccacagatga caaagcggtg gtcttgaaaa    840

ggatccatga agtccatgtg aagatggacc gcagcctgga gtaccagcct gtggaatgcg    900

ccattgtgat caacgcagcc ggagcctggt ctgcgcaaat cgcagcactg gctggtgttg    960

gagaggggcc gcctggcacc ctgcagggca ccaagctacc tgtggagccg aggaaaaggt   1020

atgtgtatgt gtggcactgc ccccagggac caggcctaga gactccgctt gttgcagaca   1080

ccagtggagc ctattttcgc cgggaaggat taggtagcaa ctacctaggt ggtcgtagcc   1140

ccactgagca ggaagaaccg gacccggcga acctggaagt ggaccatgat ttcttccagg   1200

acaaggtgtg gccccatttg gccctgaggg tcccagcttt tgagactctg aaggttcaga   1260

gcgcctgggc cggctattac gactacaaca cctttgacca gaatggcgtg gtgggccccc   1320

acccgctagt tgtcaacatg tactttgcta ctggcttcag tggtcacggg ctccagcagg   1380

cccctggcat tgggcgagct gtagcagaga tggtactgaa gggcaggttc cagaccatcg   1440

acctgagccc cttcctcttt acccgctttt acttgggaga gaagatccag gagaacaaca   1500

tcatctgagc atgtgtgctc tgcactggct ccactggctt gcatcctggc tgtgttcaca   1560

gccttgtttg ctgcttccat cttccccagt actgtgccag gccttctccc cctccccagt   1620

gtcctctcct ctcaggcagg ccattgcacc catatggctg ggcaggcaca ggcagtgagg   1680

ccgaggccaa tagcgagtga tgagcgggat cctaggactg atctgtagcc catgctgatg   1740

tcacccacca gggcaatcca tctggaggcc tgagcaccct ggcccaggac tggcttcatc   1800

ctggcactga ccaggaaaga ctgcctctga ccctcttagc agacagagcc caggcatggg   1860

agcactctgg ggcagcctgg ctcaggttta ttgattttcg tctgtttacc ctatccatta   1920

atcaatacat gtaattaact ccttccctcc aaaaaaaaaa aaaaaaa                 1967


<210>  1196
<211>  486
<212>  PRT
<213>  Homosapiens

<400>  1196

Met Ile Arg Arg Val Leu Pro His Gly Met Gly Arg Gly Leu Leu Thr 
1               5                   10                  15      


Arg Arg Pro Gly Thr Arg Arg Gly Gly Phe Ser Leu Asp Trp Asp Gly 
            20                  25                  30          


Lys Val Ser Glu Ile Lys Lys Lys Ile Lys Ser Ile Leu Pro Gly Arg 
        35                  40                  45              


Ser Cys Asp Leu Leu Gln Asp Thr Ser His Leu Pro Pro Glu His Ser 
    50                  55                  60                  


Asp Val Val Ile Val Gly Gly Gly Val Leu Gly Leu Ser Val Ala Tyr 
65                  70                  75                  80  


Trp Leu Lys Lys Leu Glu Ser Arg Arg Gly Ala Ile Arg Val Leu Val 
                85                  90                  95      


Val Glu Arg Asp His Thr Tyr Ser Gln Ala Ser Thr Gly Leu Ser Val 
            100                 105                 110         


Gly Gly Ile Cys Gln Gln Phe Ser Leu Pro Glu Asn Ile Gln Leu Ser 
        115                 120                 125             


Leu Phe Ser Ala Ser Phe Leu Arg Asn Ile Asn Glu Tyr Leu Ala Val 
    130                 135                 140                 


Val Asp Ala Pro Pro Leu Asp Leu Arg Phe Asn Pro Ser Gly Tyr Leu 
145                 150                 155                 160 


Leu Leu Ala Ser Glu Lys Asp Ala Ala Ala Met Glu Ser Asn Val Lys 
                165                 170                 175     


Val Gln Arg Gln Glu Gly Ala Lys Val Ser Leu Met Ser Pro Asp Gln 
            180                 185                 190         


Leu Arg Asn Lys Phe Pro Trp Ile Asn Thr Glu Gly Val Ala Leu Ala 
        195                 200                 205             


Ser Tyr Gly Met Glu Asp Glu Gly Trp Phe Asp Pro Trp Cys Leu Leu 
    210                 215                 220                 


Gln Gly Leu Arg Arg Lys Val Gln Ser Leu Gly Val Leu Phe Cys Gln 
225                 230                 235                 240 


Gly Glu Val Thr Arg Phe Val Ser Ser Ser Gln Arg Met Leu Thr Thr 
                245                 250                 255     


Asp Asp Lys Ala Val Val Leu Lys Arg Ile His Glu Val His Val Lys 
            260                 265                 270         


Met Asp Arg Ser Leu Glu Tyr Gln Pro Val Glu Cys Ala Ile Val Ile 
        275                 280                 285             


Asn Ala Ala Gly Ala Trp Ser Ala Gln Ile Ala Ala Leu Ala Gly Val 
    290                 295                 300                 


Gly Glu Gly Pro Pro Gly Thr Leu Gln Gly Thr Lys Leu Pro Val Glu 
305                 310                 315                 320 


Pro Arg Lys Arg Tyr Val Tyr Val Trp His Cys Pro Gln Gly Pro Gly 
                325                 330                 335     


Leu Glu Thr Pro Leu Val Ala Asp Thr Ser Gly Ala Tyr Phe Arg Arg 
            340                 345                 350         


Glu Gly Leu Gly Ser Asn Tyr Leu Gly Gly Arg Ser Pro Thr Glu Gln 
        355                 360                 365             


Glu Glu Pro Asp Pro Ala Asn Leu Glu Val Asp His Asp Phe Phe Gln 
    370                 375                 380                 


Asp Lys Val Trp Pro His Leu Ala Leu Arg Val Pro Ala Phe Glu Thr 
385                 390                 395                 400 


Leu Lys Val Gln Ser Ala Trp Ala Gly Tyr Tyr Asp Tyr Asn Thr Phe 
                405                 410                 415     


Asp Gln Asn Gly Val Val Gly Pro His Pro Leu Val Val Asn Met Tyr 
            420                 425                 430         


Phe Ala Thr Gly Phe Ser Gly His Gly Leu Gln Gln Ala Pro Gly Ile 
        435                 440                 445             


Gly Arg Ala Val Ala Glu Met Val Leu Lys Gly Arg Phe Gln Thr Ile 
    450                 455                 460                 


Asp Leu Ser Pro Phe Leu Phe Thr Arg Phe Tyr Leu Gly Glu Lys Ile 
465                 470                 475                 480 


Gln Glu Asn Asn Ile Ile 
                485     


<210>  1197
<211>  2195
<212>  DNA
<213>  Homosapiens

<400>  1197
gcccgcgcag tccgcgcagc cctcatcgca actgggcccg cgcgcagatc caccaaagag     60

aaagcagccc tgtgccagtt gctctgccag cctttcacag gagaagtgtc actagaatac    120

tacagccccc acaggctctg ctccacagaa acttaaggct gaaagagtgt ccgccatcag    180

ggacatcctc tgtcactacg gtgggaaaag aacatggcct tacataggaa gtccttctaa    240

agagctgcct gccagctgcc cttccccaga tcccgaatat cctcctggcc aggtggagca    300

gagaacagtt cctcagctgg tcatgctgag ctcataccct gatggctgct ccatgaggtc    360

aagactgggt ctcctccctc ctcccccttc accaatgcct ggtctcacgg ggctagtttt    420

gacccccacg ctatggcatc atcgacctcc ctcccagctc ctggctctcg gcctaagaag    480

cctctaggca agatggctga ctggttcagg cagaccctgc tgaagaagcc caagaagagg    540

cccaactccc cagaaagcac ctccagcgat gcttcacagc ctacctcaca ggacagccca    600

ctacccccaa gcctcagctc agtcacgtct cccagcctgc cacccacaca tgcgagtgac    660

agtggcagta gtcgctggag caaagactat gacgtctgcg tgtgccacag tgaggaagac    720

ctggtggccg cccaggacct ggtctcctac ttggaaggca gcactgccag cctgcgctgc    780

ttcctgcaac tccgggatgc aaccccaggc ggcgctatag tgtccgagct gtgccaggca    840

ctgagcagta gtcactgccg ggtgctgctc atcacgccgg gcttccttca ggacccctgg    900

tgcaagtacc agatgctgca ggccctgacc gaggctccag gggccgaggg ctgcaccatc    960

cccctgctgt cgggcctcag cagagctgcc tacccacctg agctccgatt catgtactac   1020

gtcgatggca ggggccctga tggtggcttt cgtcaagtca aagaagctgt catgcgttat   1080

ctgcagacac tcagttgaca cttgttatat catgggaccc cggaaattgg agtgaagcta   1140

gaaacagaaa acccatgcag ggcctcggac tccccaagaa ggccatgagg aagccagaaa   1200

ttggaggtgg taggaagtgg tactgatcaa tgatggccag caggactcat ctcctgccta   1260

actggacagg aagcctggca cccacttctg tcttcccctg gaactgggca ctggcgtaca   1320

ctggtatccc tcctaaagaa gtgactcacc tgactgatca gcaagaagcc tagattgcag   1380

gcctcaccat ggatggtctt cctagttgcc tggggaaacc ctggaatggg catcaggaga   1440

aagcaacaag aatccagtcc ttcacactca cactactctg ttcctcttcc cagagacatc   1500

gattcacccc aaagtgctgg gattacaggc gtgaagcacc acgcccagcc tgaaataata   1560

ttttaccttt tactttgtgc tttttgtgtt ttactcagga agtcctcccc tacatctgtt   1620

ttcttctgta tttcttttca tatttaggtc tttaatccac ctggattttt tgtttgggtt   1680

tttgttgttc tttagtcaaa gatccaattc ttttttctat ttaaataacc atcattgact   1740

gactagtcca tccttacccc acccctactg attatgatgt cactgctgtc acatattgtc   1800

atacgtgggg ggctgttact gggttctcca gtctcctccc tttactttat ctgtttgtgt   1860

atccctgtgc tggtgccaca ctgcctcgtt cactgatgtt tttaataagc ctgcaccatt   1920

tgtatgtcaa ttcttcctgc tcttcttatc catcaaaaat cactttaact tttcttgttc   1980

ctttactctt ccatataaat tgtttattca accatcaggt tccaggaaaa agcctgttag   2040

tattttcatt ggacttacat ggaatttgta gattttgaaa aaacagatat ttttatgagt   2100

cttcctattc ataaaaatag tatgtctcca tttacttatg tctttaagtg tatttcagta   2160

aagctttcta tcttttcaaa aaaaaaaaaa aaaaa                              2195


<210>  1198
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  1198

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu Ser 
    210                 215                 220     


<210>  1199
<211>  1199
<212>  DNA
<213>  Homosapiens

<400>  1199
gcccgcgcag tccgcgcagc cctcatcgca actgggcccg cgcgcagatc caccaaagag     60

aaagcagccc tgtgccagtt gctctgccag cctttcacag gagaagtgtc actagaatac    120

tacagccccc acaggctctg ctccacagaa acttaaggct gaaagagtgt ccgccatcag    180

ggacatcctc tgtcactacg gtgggaaaag aacatggcct tacataggaa gtccttctaa    240

agagctgcct gccagctgcc cttccccaga tcccgaatat cctcctggcc aggtggagca    300

gagaacagtt cctcagctgg tcatgctgag ctcataccct gatggctgct ccatgaggtc    360

aagactgggt ctcctccctc ctcccccttc accaatgcct ggtctcacgg ggctagtttt    420

gacccccacg ctatggcatc atcgacctcc ctcccagctc ctggctctcg gcctaagaag    480

cctctaggca agatggctga ctggttcagg cagaccctgc tgaagaagcc caagaagagg    540

cccaactccc cagaaagcac ctccagcgat gcttcacagc ctacctcaca ggacagccca    600

ctacccccaa gcctcagctc agtcacgtct cccagcctgc cacccacaca tgcgagtgac    660

agtggcagta gtcgctggag caaagactat gacgtctgcg tgtgccacag tgaggaagac    720

ctggtggccg cccaggacct ggtctcctac ttggaaggca gcactgccag cctgcgctgc    780

ttcctgcaac tccgggatgc aaccccaggc ggcgctatag tgtccgagct gtgccaggca    840

ctgagcagta gtcactgccg ggtgctgctc atcacgccgg gcttccttca ggacccctgg    900

tgcaagtacc agatgctgca ggccctgacc gaggctccag gggccgaggg ctgcaccatc    960

cccctgctgt cgggcctcag cagagctgcc tacccacctg agctccgatt catgtactac   1020

gtcgatggca ggggccctga tggtggcttt cgtcaagtca aagaagctgt catgcgttgt   1080

aagctactac aggagggaga aggggaacgg gattcagcta cagtatctga tctactttga   1140

cttttaggag acagccctgt agcctagtag ttcaaagcgc agcttctgga aaaggctgt    1199


<210>  1200
<211>  235
<212>  PRT
<213>  Homosapiens

<400>  1200

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Cys Lys Leu Leu Gln Glu Gly Glu Gly 
    210                 215                 220                 


Glu Arg Asp Ser Ala Thr Val Ser Asp Leu Leu 
225                 230                 235 


<210>  1201
<211>  1508
<212>  DNA
<213>  Homosapiens

<400>  1201
gggcgtcttc ggctcccacc ccggggcgtg ggcctggggg tccctcttca ctgcgcagcc     60

acctctagcc cgccgctttc gggactctca gccttctttt cccttccctg agggccggcc    120

ggcaccacaa cggggccaaa ggcagtaact cggttgaaag gcgcgccctg ggacaggtca    180

gcgggctccg ccatgcgcgg cacgcatccc gcaggagcgg gtgccagagc agggtaggcc    240

gggagttagc agcccagcca ggccgctgga ctcgggctag gggcggggcc agcgcagggg    300

gcgcaggcgc acaccgcctc cgcggcagca tggcggacgc agctcctcaa ctaggcaaga    360

ggaagcgcga attggacgtg gaggaggccc acgccgccag cacagaggaa aaggaggcag    420

gagttggaaa tggtacctgt gctcctgtcc gcttaccgtt ctccggcttc agactgcaga    480

aggtgctgag ggagtctgcg cgggacaaaa tcattttcct acacgggaag gtgaatgagg    540

cctctgggga tggggatgga gaggatgccg ttgtgatcct ggagaagacg ccatttcagg    600

tggaacaggt ggctcagctc ctgacgggca gccctgagct ccaattgcag ttctccaatg    660

atatctacag cacctatcac ttgttccctc caagacaact gaatgatgta aagacgaccg    720

tggtttaccc tgccacagag aaacacctgc agaagtacct gcgccaggac ctccgcctga    780

tccgagagac gggagatgac tacaggaata ttactttacc ccacctggag tcccagagcc    840

tcagcatcca gtgggtgtat aacattctcg acaagaaggc tgaagcggac cggattgttt    900

tcgagaaccc agatccctct gatggttttg tcctcatccc tgacctcaag tggaaccaac    960

agcagctcga tgacttgtac ttgatcgcca tctgccatcg ccggggcatc agatccctac   1020

gcgaccttac tccggagcac ttgccgctgc tcaggaacat cctccaccag gggcaggagg   1080

ccatcctgca gcgctaccgg atgaagggag accatctgcg agtatacctg cactacctgc   1140

cctcctacta ccacctgcat gtgcacttca ccgccctggg cttcgaggcc cccggctcag   1200

gcgtggagcg ggcccacctg ctggctgagg tgatcgagaa cttggagtgt gaccctaggc   1260

actaccagca gcgcacgctc accttcgccc tcagggctga cgaccccctg ctcaagctct   1320

tgcaggaggc tcagcaaagc tgaattaact caggcagaag agcacagatg tgtgggattg   1380

ggggaggagt ggggacaaga ttttttatct ccaagtgaat tttctaaaaa tgtattttat   1440

accggcttat tcctagtatt gaataaacta gcgggctcaa aaaaaaaaaa aaaaaaaaaa   1500

aaaaaaaa                                                            1508


<210>  1202
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  1202

Met Ala Asp Ala Ala Pro Gln Leu Gly Lys Arg Lys Arg Glu Leu Asp 
1               5                   10                  15      


Val Glu Glu Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val 
            20                  25                  30          


Gly Asn Gly Thr Cys Ala Pro Val Arg Leu Pro Phe Ser Gly Phe Arg 
        35                  40                  45              


Leu Gln Lys Val Leu Arg Glu Ser Ala Arg Asp Lys Ile Ile Phe Leu 
    50                  55                  60                  


His Gly Lys Val Asn Glu Ala Ser Gly Asp Gly Asp Gly Glu Asp Ala 
65                  70                  75                  80  


Val Val Ile Leu Glu Lys Thr Pro Phe Gln Val Glu Gln Val Ala Gln 
                85                  90                  95      


Leu Leu Thr Gly Ser Pro Glu Leu Gln Leu Gln Phe Ser Asn Asp Ile 
            100                 105                 110         


Tyr Ser Thr Tyr His Leu Phe Pro Pro Arg Gln Leu Asn Asp Val Lys 
        115                 120                 125             


Thr Thr Val Val Tyr Pro Ala Thr Glu Lys His Leu Gln Lys Tyr Leu 
    130                 135                 140                 


Arg Gln Asp Leu Arg Leu Ile Arg Glu Thr Gly Asp Asp Tyr Arg Asn 
145                 150                 155                 160 


Ile Thr Leu Pro His Leu Glu Ser Gln Ser Leu Ser Ile Gln Trp Val 
                165                 170                 175     


Tyr Asn Ile Leu Asp Lys Lys Ala Glu Ala Asp Arg Ile Val Phe Glu 
            180                 185                 190         


Asn Pro Asp Pro Ser Asp Gly Phe Val Leu Ile Pro Asp Leu Lys Trp 
        195                 200                 205             


Asn Gln Gln Gln Leu Asp Asp Leu Tyr Leu Ile Ala Ile Cys His Arg 
    210                 215                 220                 


Arg Gly Ile Arg Ser Leu Arg Asp Leu Thr Pro Glu His Leu Pro Leu 
225                 230                 235                 240 


Leu Arg Asn Ile Leu His Gln Gly Gln Glu Ala Ile Leu Gln Arg Tyr 
                245                 250                 255     


Arg Met Lys Gly Asp His Leu Arg Val Tyr Leu His Tyr Leu Pro Ser 
            260                 265                 270         


Tyr Tyr His Leu His Val His Phe Thr Ala Leu Gly Phe Glu Ala Pro 
        275                 280                 285             


Gly Ser Gly Val Glu Arg Ala His Leu Leu Ala Glu Val Ile Glu Asn 
    290                 295                 300                 


Leu Glu Cys Asp Pro Arg His Tyr Gln Gln Arg Thr Leu Thr Phe Ala 
305                 310                 315                 320 


Leu Arg Ala Asp Asp Pro Leu Leu Lys Leu Leu Gln Glu Ala Gln Gln 
                325                 330                 335     


Ser 
    


<210>  1203
<211>  2289
<212>  DNA
<213>  Homosapiens

<400>  1203
agaaagggcg gggtggagga gggggaaggg cgggggtgat gccgcgcggt cgcaggcttg     60

ggatggtgtt cgcgcctccg agacccggac agaggcaagc aggggcgccg tgggtgccag    120

agaggcggaa gaggaggcct gatggggtca gcacagtgtt tccggagccc cacgtatcaa    180

cagcccagtg ccgggagcgc caggggctcc aaggaaacta tcagacccat tccctgtccc    240

caggaagctt accatccagc ggcacagaga aggctcacca tggactccat tcaagaacga    300

ggcaggatag gatgtgaata agtgcaaggt gtgagtgact gacagtaagt gcaagggggt    360

tcagagaagt ggcagctcca agcctgcttc tgctgaagct ggagggctta tctgtcaaga    420

acccccaact caggaagctc tgctccaagt gagctgagta aggagagtct gcctccaagt    480

tgttcctctg caggtgactg tgctccatgc taaatcattc cttgcacggg cagaagctgt    540

ttggcattgc accagtgtct gattttgttt gaatatggtg cctttggctt aatcagtcag    600

acatgcattc aacaactatt tatttattta tttatttatt tatttattta ttattttgag    660

acagagtctc gctctgtcgc caggcggagg ttgcagtgag ccgagattga gccactgcac    720

tccagcctgg caacagagtg agactgtctc aaaaagtaaa taaatagaaa ctcttggttc    780

catgcgtagt ctagcatttt gtagcacttc taatcacgaa gttattttta atatttgttt    840

ggtctgttat acaaaatgta gactggatgg cttataaact acagaaatct ctcacagttc    900

tgtaggctag aaagtctaag atgaagatgc cagcagcctg cttcctggtt catacaaggt    960

catcttctca ctgtaacctc acagtgagag gaagggccta ggggtgactc tgggatctct   1020

tttatgaggc actaatccca ttaatggggg ccccccaccc tcatggccta atcacctccc   1080

aaaggcccca cgattgcctt gggtgttagg atttccacat atgaatttta ggggaacaca   1140

gacgttcagg ccatagcaaa tatcttgccc aaatatctct agttccatcc ttttggtcac   1200

tctcagacca gaacatttac tgagtgatta ctatgtccca caaaattctt atttaaccct   1260

cagaaaaacc gtctggggga agcattgtta tcactcctat ttcatgagca gttatgtaac   1320

ttgccccaga taagacttgg ttatggcaca gattctgtgt tggagccttc agaccactct   1380

acttcccaag caggggagga acagaacatt aaagattttc ttggccttgg ctttcatttc   1440

ttcatcgtgg ttctgaaagg aaaattggct acagtcttaa atgtatgtgt gggcccacgc   1500

tagaagctca gctctcagtg ccagccacac tgagccctgg tctccctaac ttccgggcct   1560

ttactctgct tgtcattggg ctgataacca agatccagcc tagagcacaa gaagacaaac   1620

gctgcgtgat ctcgtgtgta gaacctaaca aagtggaact cacagaagca gagagtagaa   1680

tggtggttgc ctgttggaat ggggagatgg tcagagaatg caaactttca gttggatggg   1740

aggaagaagt tccagagatc tattgtgcca catggtgaca atagttaata acaatgtact   1800

gggcgggggg tggtggccta cgcctgtaat cccagcactt tgggaagctg aggcagacag   1860

atcacttgag gtcaggagtt ctagaccagc ttgtccaaca tggtgaaacc ccgtctctac   1920

tataaaacta caaaattagc caggtgtggt ggtgtgcgcc tgtaatctca gctacttggg   1980

aggctgaatc gcttgaaccc aggaggtgga ggttgcagtg agtcgagact gcgccactgc   2040

cctccagcct gggtgacaca gtgagactct gtttcaaaaa aacaaaaaaa gcaatgtact   2100

gtatacttga aaattgctca cagagatttt aaatgttctc accattacaa aatgataaat   2160

atgtgacata atgcatatgt taattagccc gatttagtga ttccacagtg tatacatata   2220

acaaaacatg ttgtacacca taaatgtata ctatttttat ttgccaatta aatatatttt   2280

tttaaagtt                                                           2289


<210>  1204
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  1204

Met Pro Arg Gly Arg Arg Leu Gly Met Val Phe Ala Pro Pro Arg Pro 
1               5                   10                  15      


Gly Gln Arg Gln Ala Gly Ala Pro Trp Val Pro Glu Arg Arg Lys Arg 
            20                  25                  30          


Arg Pro Asp Gly Val Ser Thr Val Phe Pro Glu Pro His Val Ser Thr 
        35                  40                  45              


Ala Gln Cys Arg Glu Arg Gln Gly Leu Gln Gly Asn Tyr Gln Thr His 
    50                  55                  60                  


Ser Leu Ser Pro Gly Ser Leu Pro Ser Ser Gly Thr Glu Lys Ala His 
65                  70                  75                  80  


His Gly Leu His Ser Arg Thr Arg Gln Asp Arg Met 
                85                  90          


<210>  1205
<211>  1766
<212>  DNA
<213>  Homosapiens

<400>  1205
cggtcaggtc cagcacttgg gagctgactg tgctggaggt gacaggcttt gcggggtccg     60

cctgtgtgca ggagtcgcaa ggtcgctgag caggacccaa aggtggcccg aggcagccgg    120

gatgacagct ctccccagga atcctgctgc ctgctgagaa acatggtcag caagtcccgc    180

tggaagctcc tggccatgtt ggctctggtc ctggtcgtca tggtgtggta ttccatctcc    240

cgggaagaca gtttttattt tcccatccca gagaagaagg agccgtgcct ccagggtgag    300

gcagagagca aggcctctaa gctctttggc aactactccc gggatcagcc catcttcctg    360

cggcttgagg attatttctg ggtcaagacg ccatctgctt acgagctgcc ctatgggacc    420

aaggggagtg aggatctgct cctccgggtg ctagccatca ccagctcctc catccccaag    480

aacatccaga gcctcaggtg ccgccgctgt gtggtcgtgg ggaacgggca ccggctgcgg    540

aacagctcac tgggagatgc catcaacaag tacgatgtgg tcatcagatt gaacaatgcc    600

ccagtggctg gctatgaggg tgacgtgggc tccaagacca ccatgcgtct cttctaccct    660

gaatctgccc acttcgaccc caaagtagaa aacaacccag acacactcct cgtcctggta    720

gctttcaagg caatggactt ccactggatt gagaccatcc tgagtgataa gaagcgggtg    780

cgaaagggtt tctggaaaca gcctcccctc atctgggatg tcaatcctaa acagattcgg    840

attctcaacc ccttcttcat ggagattgca gctgacaaac tgctgagcct gccaatgcaa    900

cagccacgga agattaagca gaagcccacc acgggcctgt tggccatcac gctggccctc    960

cacctctgtg acttggtgca cattgccggc tttggctacc cagacgccta caacaagaag   1020

cagaccattc actactatga gcagatcacg ctcaagtcca tggcggggtc aggccataat   1080

gtctcccaag aggccctggc cattaagcgg atgctggaga tgggagctat caagaacctc   1140

acgtccttct gacctgggca agagctgtag cctgtcggtt gcctactctg ctgtctgggt   1200

gacccccatg cgtggctgtg ggggtggctg gtgccagtat gacccacttg gactcacccc   1260

ctcttgggga gggagttctg ggcctggcca ggtctgagat gaggccatgc ccctggctgc   1320

tcttatggag ccgagatcca gtcagggtgg gggcgctgga gccgtgggag cccggccagg   1380

gcagggggct cgtcgctgtg gcaccccctc tctgccagca ccaagagatt atttaatggg   1440

ctatttaatt aaggggtagg aaggtgctgt gggctggtcc cacacatcca ggaaagaggc   1500

cagtagagaa ttctgcccac tttttataaa aacttacagc gatggcccca ccaaggccta   1560

gacacggcac tggcctccca ggagggcagg ggcattggga atgggtgggt gccctccaga   1620

gaggggctgc tacctcccag caggcatggg aagagcactg gtgtgggggt tccaccgaga   1680

aggggacctc atctagaaaa gaggttacaa acctaccatt aaactatttt tcctaaaacg   1740

gaaaaaaaaa aaaaaaaaaa aaaaaa                                        1766


<210>  1206
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  1206

Met Val Ser Lys Ser Arg Trp Lys Leu Leu Ala Met Leu Ala Leu Val 
1               5                   10                  15      


Leu Val Val Met Val Trp Tyr Ser Ile Ser Arg Glu Asp Ser Phe Tyr 
            20                  25                  30          


Phe Pro Ile Pro Glu Lys Lys Glu Pro Cys Leu Gln Gly Glu Ala Glu 
        35                  40                  45              


Ser Lys Ala Ser Lys Leu Phe Gly Asn Tyr Ser Arg Asp Gln Pro Ile 
    50                  55                  60                  


Phe Leu Arg Leu Glu Asp Tyr Phe Trp Val Lys Thr Pro Ser Ala Tyr 
65                  70                  75                  80  


Glu Leu Pro Tyr Gly Thr Lys Gly Ser Glu Asp Leu Leu Leu Arg Val 
                85                  90                  95      


Leu Ala Ile Thr Ser Ser Ser Ile Pro Lys Asn Ile Gln Ser Leu Arg 
            100                 105                 110         


Cys Arg Arg Cys Val Val Val Gly Asn Gly His Arg Leu Arg Asn Ser 
        115                 120                 125             


Ser Leu Gly Asp Ala Ile Asn Lys Tyr Asp Val Val Ile Arg Leu Asn 
    130                 135                 140                 


Asn Ala Pro Val Ala Gly Tyr Glu Gly Asp Val Gly Ser Lys Thr Thr 
145                 150                 155                 160 


Met Arg Leu Phe Tyr Pro Glu Ser Ala His Phe Asp Pro Lys Val Glu 
                165                 170                 175     


Asn Asn Pro Asp Thr Leu Leu Val Leu Val Ala Phe Lys Ala Met Asp 
            180                 185                 190         


Phe His Trp Ile Glu Thr Ile Leu Ser Asp Lys Lys Arg Val Arg Lys 
        195                 200                 205             


Gly Phe Trp Lys Gln Pro Pro Leu Ile Trp Asp Val Asn Pro Lys Gln 
    210                 215                 220                 


Ile Arg Ile Leu Asn Pro Phe Phe Met Glu Ile Ala Ala Asp Lys Leu 
225                 230                 235                 240 


Leu Ser Leu Pro Met Gln Gln Pro Arg Lys Ile Lys Gln Lys Pro Thr 
                245                 250                 255     


Thr Gly Leu Leu Ala Ile Thr Leu Ala Leu His Leu Cys Asp Leu Val 
            260                 265                 270         


His Ile Ala Gly Phe Gly Tyr Pro Asp Ala Tyr Asn Lys Lys Gln Thr 
        275                 280                 285             


Ile His Tyr Tyr Glu Gln Ile Thr Leu Lys Ser Met Ala Gly Ser Gly 
    290                 295                 300                 


His Asn Val Ser Gln Glu Ala Leu Ala Ile Lys Arg Met Leu Glu Met 
305                 310                 315                 320 


Gly Ala Ile Lys Asn Leu Thr Ser Phe 
                325                 


<210>  1207
<211>  2337
<212>  DNA
<213>  Homosapiens

<400>  1207
atgaaaccct tccagctcga tctgctcttc gtctgcttct tcctcttcag tcaagagctg     60

ggcctccaga agagaggatg ctgtctggtg ctgggctaca tggccaagga caagtttcgg    120

agaatgaatg aaggccaagt ctattccttc agccagcagc cccaggacca ggtggtggtg    180

tcgggacagc cagtgacgct actttgcgcc atccccgaat acgatggctt cgttctgtgg    240

atcaaggacg gcttggctct gggtgtgggc agggacctct caagttaccc acagtacctg    300

gtggtaggga accacctgtc aggggagcac cacctgaaga tcctgcgggc agagctgcaa    360

gacgatgcgg tgtacgagtg ccaggccatc caggccgcca tccgctcccg ccccgcacgc    420

ctcacagtcc tggtgccgcc tgatgatccc gtcatcctgg ggggccctgt gatcagcctg    480

cgtgcggggg accctctcaa cctcacctgc cacgcagaca atgccaagcc tgcagcctcc    540

atcatctggt tgcgaaaggg agaggtcatc aatggggcca cctactccaa gaccctgctt    600

cgggacggca agcgggagag catcgtcagc accctcttca tctcccctgg tgacgtggag    660

aatggccaga gcatcgtgtg tcgtgccacc aacaaagcca tccccggagg aaaggagacg    720

tcggtcacca ttgacatcca gcaccctcca ctggtcaacc tctcggtgga gccacagcca    780

gtgctggagg acaacgtcgt cactttccac tgctctgcaa aggccaaccc agctgtcacc    840

cagtacaggt gggccaagcg gggccagatc atcaaggagg catctggaga ggtgtacagg    900

accacagtgg actacacgta cttctcagag cccgtctcct gtgaggtgac caacgccctg    960

ggcagcacca acctcagccg cacggttgac gtctactttg ggccccggat gaccacagaa   1020

ccccaatcct tgctcgtgga tctgggctct gatgccatct tcagctgcgc ctggaccggc   1080

aacccatccc tgaccatcgt ctggatgaag cggggctccg gagtggtcct gagcaatgag   1140

aagaccctga ccctcaaatc cgtgcgccag gaggacgcgg gcaagtacgt gtgccgggct   1200

gtggtgcccc gtgtgggagc cggggagaga gaggtgaccc tgaccgtcaa tggacccccc   1260

atcatctcca gcacccagac ccagcacgcc ctccacggcg agaagggcca gatcaagtgc   1320

ttcatccgga gcacgccgcc gccggaccgc atcgcctggt cctggaagga gaacgttctg   1380

gagtcgggca catcggggcg ctatacggtg gagaccatca gcaccgagga gggcgtcatc   1440

tccaccctga ccatcagcaa catcgtgcgg gccgacttcc agaccatcta caactgcacg   1500

gcctggaaca gcttcggctc cgacactgag atcatccggc tcaaggagca aggttcggaa   1560

atgaagtcgg gagccgggct ggaagcagag tctgtgccga tggccgtcat cattggggtg   1620

gccgtaggag ctggtgtggc cttcctcgtc cttatggcaa ccatcgtggc gttctgctgt   1680

gcccgttccc agagaaatct caaaggtgtt gtgtcagcca aaaatgatat ccgagtggaa   1740

attgtccaca aggaaccagc ctctggtcgg gagggtgagg agcactccac catcaagcag   1800

ctgatgatgg accggggtga attccagcaa gactcagtcc tgaaacagct ggaggtcctc   1860

aaagaagagg agaaagagtt tcagaacctg aaggacccca ccaatggcta ctacagcgtc   1920

aacaccttca aagagcacca ctcaaccccg accatctccc tctccagctg ccagcccgac   1980

ctgcgtcctg cgggcaagca gcgtgtgccc acaggcatgt ccttcaccaa catctacagc   2040

accctgagcg gccagggccg cctctacgac tacgggcagc ggtttgtgct gggcatgggc   2100

agctcgtcca tcgagctttg tgagcgggag ttccagagag gctccctcag cgacagcagc   2160

tccttcctgg acacgcagtg tgacagcagc gtcagcagca gcggcaagca ggatggctat   2220

gtgcagttcg acaaggccag caaggcttct gcttcctcct cccaccactc ccagtcctcg   2280

tcccagaact ctgaccccag tcgacccctg cagcggcgga tgcagactca cgtctaa      2337


<210>  1208
<211>  778
<212>  PRT
<213>  Homosapiens

<400>  1208

Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe Phe Leu Phe 
1               5                   10                  15      


Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cys Leu Val Leu Gly 
            20                  25                  30          


Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly Gln Val Tyr 
        35                  40                  45              


Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser Gly Gln Pro 
    50                  55                  60                  


Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe Val Leu Trp 
65                  70                  75                  80  


Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu Ser Ser Tyr 
                85                  90                  95      


Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu His His Leu 
            100                 105                 110         


Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr Glu Cys Gln 
        115                 120                 125             


Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu Thr Val Leu 
    130                 135                 140                 


Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val Ile Ser Leu 
145                 150                 155                 160 


Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp Asn Ala Lys 
                165                 170                 175     


Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val Ile Asn Gly 
            180                 185                 190         


Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg Glu Ser Ile 
        195                 200                 205             


Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn Gly Gln Ser 
    210                 215                 220                 


Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly Lys Glu Thr 
225                 230                 235                 240 


Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn Leu Ser Val 
                245                 250                 255     


Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe His Cys Ser 
            260                 265                 270         


Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala Lys Arg Gly 
        275                 280                 285             


Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr Thr Val Asp 
    290                 295                 300                 


Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr Asn Ala Leu 
305                 310                 315                 320 


Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe Gly Pro Arg 
                325                 330                 335     


Met Thr Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly Ser Asp Ala 
            340                 345                 350         


Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr Ile Val Trp 
        355                 360                 365             


Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys Thr Leu Thr 
    370                 375                 380                 


Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val Cys Arg Ala 
385                 390                 395                 400 


Val Val Pro Arg Val Gly Ala Gly Glu Arg Glu Val Thr Leu Thr Val 
                405                 410                 415     


Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His Ala Leu His 
            420                 425                 430         


Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr Pro Pro Pro 
        435                 440                 445             


Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu Ser Gly Thr 
    450                 455                 460                 


Ser Gly Arg Tyr Thr Val Glu Thr Ile Ser Thr Glu Glu Gly Val Ile 
465                 470                 475                 480 


Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe Gln Thr Ile 
                485                 490                 495     


Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr Glu Ile Ile 
            500                 505                 510         


Arg Leu Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala Gly Leu Glu 
        515                 520                 525             


Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala Val Gly Ala 
    530                 535                 540                 


Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala Phe Cys Cys 
545                 550                 555                 560 


Ala Arg Ser Gln Arg Asn Leu Lys Gly Val Val Ser Ala Lys Asn Asp 
                565                 570                 575     


Ile Arg Val Glu Ile Val His Lys Glu Pro Ala Ser Gly Arg Glu Gly 
            580                 585                 590         


Glu Glu His Ser Thr Ile Lys Gln Leu Met Met Asp Arg Gly Glu Phe 
        595                 600                 605             


Gln Gln Asp Ser Val Leu Lys Gln Leu Glu Val Leu Lys Glu Glu Glu 
    610                 615                 620                 


Lys Glu Phe Gln Asn Leu Lys Asp Pro Thr Asn Gly Tyr Tyr Ser Val 
625                 630                 635                 640 


Asn Thr Phe Lys Glu His His Ser Thr Pro Thr Ile Ser Leu Ser Ser 
                645                 650                 655     


Cys Gln Pro Asp Leu Arg Pro Ala Gly Lys Gln Arg Val Pro Thr Gly 
            660                 665                 670         


Met Ser Phe Thr Asn Ile Tyr Ser Thr Leu Ser Gly Gln Gly Arg Leu 
        675                 680                 685             


Tyr Asp Tyr Gly Gln Arg Phe Val Leu Gly Met Gly Ser Ser Ser Ile 
    690                 695                 700                 


Glu Leu Cys Glu Arg Glu Phe Gln Arg Gly Ser Leu Ser Asp Ser Ser 
705                 710                 715                 720 


Ser Phe Leu Asp Thr Gln Cys Asp Ser Ser Val Ser Ser Ser Gly Lys 
                725                 730                 735     


Gln Asp Gly Tyr Val Gln Phe Asp Lys Ala Ser Lys Ala Ser Ala Ser 
            740                 745                 750         


Ser Ser His His Ser Gln Ser Ser Ser Gln Asn Ser Asp Pro Ser Arg 
        755                 760                 765             


Pro Leu Gln Arg Arg Met Gln Thr His Val 
    770                 775             


<210>  1209
<211>  780
<212>  DNA
<213>  Homosapiens

<400>  1209
atggtgggat ctctaacgct gcgaattctg gaaactgagc tggaggcctt tggcaacctc     60

catagcaaca agatgaagac ccacattgct tctggaagag tctttcagaa accagctgct    120

ccaaccactg gcttctggaa tgttttcaat cttcagtctc ccgctccaga ctttgacttt    180

gctcggtgga cttttgtgat tagccgcaaa ctagacccaa acctagctga tccgactgct    240

ggccagttct tccccccatt ccacagccct ccatcaacag ctatcccagc tgatccgact    300

gccggccagc tcttcccccc attccacagc cctccatcaa cagatatccc agctgatccg    360

actgccggcc agctcttccc cccattccac agccctccat caacagatat cccagctgat    420

ccgactgccg gccagctctt cccaccattc cacagccctc catcaacaga caccccactg    480

atccgactgc cggccagctc ttccaccatt ccacagccct ccatcaacag ataccccact    540

gatccgactg ccggccagct cttcccacca ttccacagcc ctccatcaac agatatccca    600

gctgatccga ctgccggcca gctcttcccc ccattccaca gccctccatc aacagatatc    660

ccagctgatc cgactgccgg ccagctcttc cccccattcc acagccctcc atcaacagat    720

atcccagctg atccgactgc cggccagctc ttccaccatt ccacagccct ccatcaatag    780


<210>  1210
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  1210

Met Val Gly Ser Leu Thr Leu Arg Ile Leu Glu Thr Glu Leu Glu Ala 
1               5                   10                  15      


Phe Gly Asn Leu His Ser Asn Lys Met Lys Thr His Ile Ala Ser Gly 
            20                  25                  30          


Arg Val Phe Gln Lys Pro Ala Ala Pro Thr Thr Gly Phe Trp Asn Val 
        35                  40                  45              


Phe Asn Leu Gln Ser Pro Ala Pro Asp Phe Asp Phe Ala Arg Trp Thr 
    50                  55                  60                  


Phe Val Ile Ser Arg Lys Leu Asp Pro Asn Leu Ala Asp Pro Thr Ala 
65                  70                  75                  80  


Gly Gln Phe Phe Pro Pro Phe His Ser Pro Pro Ser Thr Ala Ile Pro 
                85                  90                  95      


Ala Asp Pro Thr Ala Gly Gln Leu Phe Pro Pro Phe His Ser Pro Pro 
            100                 105                 110         


Ser Thr Asp Ile Pro Ala Asp Pro Thr Ala Gly Gln Leu Phe Pro Pro 
        115                 120                 125             


Phe His Ser Pro Pro Ser Thr Asp Ile Pro Ala Asp Pro Thr Ala Gly 
    130                 135                 140                 


Gln Leu Phe Pro Pro Phe His Ser Pro Pro Ser Thr Asp Thr Pro Leu 
145                 150                 155                 160 


Ile Arg Leu Pro Ala Ser Ser Ser Thr Ile Pro Gln Pro Ser Ile Asn 
                165                 170                 175     


Arg Tyr Pro Thr Asp Pro Thr Ala Gly Gln Leu Phe Pro Pro Phe His 
            180                 185                 190         


Ser Pro Pro Ser Thr Asp Ile Pro Ala Asp Pro Thr Ala Gly Gln Leu 
        195                 200                 205             


Phe Pro Pro Phe His Ser Pro Pro Ser Thr Asp Ile Pro Ala Asp Pro 
    210                 215                 220                 


Thr Ala Gly Gln Leu Phe Pro Pro Phe His Ser Pro Pro Ser Thr Asp 
225                 230                 235                 240 


Ile Pro Ala Asp Pro Thr Ala Gly Gln Leu Phe His His Ser Thr Ala 
                245                 250                 255     


Leu His Gln 
            


<210>  1211
<211>  3105
<212>  DNA
<213>  Homosapiens

<400>  1211
ccacctgcca ggagcacgtc ccgccggcag tcgcaggagc cctgggagcc gccgccatgg     60

gaatgtccaa atcacacagt ttctttggtt atcccctgag catcttcttc atcgtggtca    120

atgagttttg cgaaagattt tcctactatg gaatgcgagc aatcctgatt ctgtacttca    180

caaatttcat cagctgggat gataacctgt ccaccgccat ctaccatacg tttgtggctc    240

tgtgctacct gacgccaatt ctcggagctc ttatcgccga ctcgtggctg ggaaagttca    300

agaccattgt gtcgctctcc attgtctaca caattggaca agcagtcacc tcagtaagct    360

ccattaatga cctcacagac cacaaccatg atggcacccc cgacagcctt cctgtgcacg    420

tggtgctgtc cttgatcggc ctggccctga tagctctcgg gactggagga atcaaaccct    480

gtgtgtctgc gtttggtgga gatcagtttg aagagggcca ggagaaacaa agaaacagat    540

ttttttccat cttttacttg gctattaatg ctggaagttt gctttccaca atcatcacac    600

ccatgctcag agttcaacaa tgtggaattc acagtaaaca agcttgttac ccactggcct    660

ttggggttcc tgctgctctc atggctgtag ccctgattgt gtttgtcctt ggcagtggga    720

tgtacaagaa gttcaagcca cagggcaaca tcatgggtaa agtggccaag tgcatcggtt    780

ttgccatcaa aaatagattt aggcatcgga gtaaggcatt tcccaagagg gagcactggc    840

tggactgggc taaagagaaa tacgatgagc ggctcatctc ccaaattaag atggttacga    900

gggtgatgtt cctgtatatt ccactcccaa tgttctgggc cttgtttgac cagcagggct    960

ccaggtggac actgcaggca acaactatgt ccgggaaaat cggagctctt gaaattcagc   1020

ccgatcagat gcagaccgtg aacgccatcc tgatcgtgat catggtcccg atcttcgatg   1080

ctgtgctgta ccctctcatt gcaaaatgtg gcttcaattt cacctccttg aagaagatgg   1140

cagttggcat ggtcctggcc tccatggcct ttgtggtggc tgccatcgtg caggtggaaa   1200

tcgataaaac tcttccagtc ttccccaaag gaaacgaagt ccaaattaaa gttttgaata   1260

taggaaacaa taccatgaat atatctcttc ctggagagat ggtgacactt ggcccaatgt   1320

ctcaaacaaa tgcatttatg acttttgatg taaacaaact gacaaggata aacatttctt   1380

ctcctggatc accagtcact gctgtaactg acgacttcaa gcagggccaa cgccacacgc   1440

ttctagtgtg ggcccccaat cactaccagg tggtaaagga tggtcttaac cagaagccag   1500

aaaaagggga aaatggaatc agatttgtaa atacttttaa cgagctcatc accatcacaa   1560

tgagtgggaa agtttatgca aacatcagca gctacaatgc cagcacatac cagttttttc   1620

cttctggcat aaaaggcttc acaataagct caacagagat tccgccacaa tgtcaaccta   1680

atttcaatac tttctacctt gaatttggta gtgcttatac ctatatagtc caaaggaaga   1740

atgacagctg ccctgaagtg aaggtgtttg aagatatttc agccaacaca gttaacatgg   1800

ctctgcaaat cccgcagtat tttcttctca cctgtggcga agtggtcttc tctgtcacgg   1860

gattggaatt ctcatattct caggctcctt ccaacatgaa gtcggtgctt caggcaggat   1920

ggctgctgac cgtggctgtt ggcaacatca ttgtgctcat cgtggcaggg gcaggccagt   1980

tcagcaaaca gtgggccgag tacattctat ttgccgcgtt gcttctggtc gtctgtgtaa   2040

tttttgccat catggctcgg ttctatactt acatcaaccc agcggagatc gaagctcaat   2100

ttgatgagga tgaaaagaaa aacagactgg aaaagagtaa cccatatttc atgtcagggg   2160

ccaattcaca gaaacagatg tgaaggtcag gaggcaagtg gaggatggac tgggcccgca   2220

gatgccctga cctctgcccc caggtagcag gacactccat tggatggccc ctgatgagga   2280

agacttcaga attgggaact aaaccatgaa tgctattttc ttttttcttt ttcttttctt   2340

tttttttttt ttttttttga gacagagttt tgctcttgtt gtccaggctg gagtgcaatg   2400

gcacgatctc agctcactgc aacctccgcc tcccaggttc aagtaattct cctgcctcag   2460

cctcccgagt ggctgggatt agcggcatgc accaccacgc ccagctattt ttgtattttt   2520

agtagagatg gggtttcacc atgttaacca ggatggtctc gatctcttga cctggtgatc   2580

tgcccacctc ggcctgccaa agtgctggga ttacaggctt gagctaccgc gcccggccgt   2640

gaacgctatt ttctaagcag ccagcagtga atctaaaact ctggaagaag tcttctgttt   2700

gaaaggctta tttaagccac acgtacacac actgtcttag agtactgtga gcccacccca   2760

cattggtcat cttccctatc acacaaatga tgttattttg gactagctta attttgaaat   2820

ggtaacaaag tttcctattc catactgttc atttctaata ctcttacgaa aactattcta   2880

aaggaggcag gagccaaggc caaaagtgaa cgtacaggtt taaaatggct gtgataaggg   2940

ccagctggta ttaactgata actttacctt tgggtttttg ttattttgtt tttctagtcc   3000

ctacctgtgt ttaaattatg gataactcga aagacaggct caggtgaagg ccgagtaatg   3060

attttttttg aagtttcaat ggtgtgaaat aaatttctgt tctta                   3105


<210>  1212
<211>  708
<212>  PRT
<213>  Homosapiens

<400>  1212

Met Gly Met Ser Lys Ser His Ser Phe Phe Gly Tyr Pro Leu Ser Ile 
1               5                   10                  15      


Phe Phe Ile Val Val Asn Glu Phe Cys Glu Arg Phe Ser Tyr Tyr Gly 
            20                  25                  30          


Met Arg Ala Ile Leu Ile Leu Tyr Phe Thr Asn Phe Ile Ser Trp Asp 
        35                  40                  45              


Asp Asn Leu Ser Thr Ala Ile Tyr His Thr Phe Val Ala Leu Cys Tyr 
    50                  55                  60                  


Leu Thr Pro Ile Leu Gly Ala Leu Ile Ala Asp Ser Trp Leu Gly Lys 
65                  70                  75                  80  


Phe Lys Thr Ile Val Ser Leu Ser Ile Val Tyr Thr Ile Gly Gln Ala 
                85                  90                  95      


Val Thr Ser Val Ser Ser Ile Asn Asp Leu Thr Asp His Asn His Asp 
            100                 105                 110         


Gly Thr Pro Asp Ser Leu Pro Val His Val Val Leu Ser Leu Ile Gly 
        115                 120                 125             


Leu Ala Leu Ile Ala Leu Gly Thr Gly Gly Ile Lys Pro Cys Val Ser 
    130                 135                 140                 


Ala Phe Gly Gly Asp Gln Phe Glu Glu Gly Gln Glu Lys Gln Arg Asn 
145                 150                 155                 160 


Arg Phe Phe Ser Ile Phe Tyr Leu Ala Ile Asn Ala Gly Ser Leu Leu 
                165                 170                 175     


Ser Thr Ile Ile Thr Pro Met Leu Arg Val Gln Gln Cys Gly Ile His 
            180                 185                 190         


Ser Lys Gln Ala Cys Tyr Pro Leu Ala Phe Gly Val Pro Ala Ala Leu 
        195                 200                 205             


Met Ala Val Ala Leu Ile Val Phe Val Leu Gly Ser Gly Met Tyr Lys 
    210                 215                 220                 


Lys Phe Lys Pro Gln Gly Asn Ile Met Gly Lys Val Ala Lys Cys Ile 
225                 230                 235                 240 


Gly Phe Ala Ile Lys Asn Arg Phe Arg His Arg Ser Lys Ala Phe Pro 
                245                 250                 255     


Lys Arg Glu His Trp Leu Asp Trp Ala Lys Glu Lys Tyr Asp Glu Arg 
            260                 265                 270         


Leu Ile Ser Gln Ile Lys Met Val Thr Arg Val Met Phe Leu Tyr Ile 
        275                 280                 285             


Pro Leu Pro Met Phe Trp Ala Leu Phe Asp Gln Gln Gly Ser Arg Trp 
    290                 295                 300                 


Thr Leu Gln Ala Thr Thr Met Ser Gly Lys Ile Gly Ala Leu Glu Ile 
305                 310                 315                 320 


Gln Pro Asp Gln Met Gln Thr Val Asn Ala Ile Leu Ile Val Ile Met 
                325                 330                 335     


Val Pro Ile Phe Asp Ala Val Leu Tyr Pro Leu Ile Ala Lys Cys Gly 
            340                 345                 350         


Phe Asn Phe Thr Ser Leu Lys Lys Met Ala Val Gly Met Val Leu Ala 
        355                 360                 365             


Ser Met Ala Phe Val Val Ala Ala Ile Val Gln Val Glu Ile Asp Lys 
    370                 375                 380                 


Thr Leu Pro Val Phe Pro Lys Gly Asn Glu Val Gln Ile Lys Val Leu 
385                 390                 395                 400 


Asn Ile Gly Asn Asn Thr Met Asn Ile Ser Leu Pro Gly Glu Met Val 
                405                 410                 415     


Thr Leu Gly Pro Met Ser Gln Thr Asn Ala Phe Met Thr Phe Asp Val 
            420                 425                 430         


Asn Lys Leu Thr Arg Ile Asn Ile Ser Ser Pro Gly Ser Pro Val Thr 
        435                 440                 445             


Ala Val Thr Asp Asp Phe Lys Gln Gly Gln Arg His Thr Leu Leu Val 
    450                 455                 460                 


Trp Ala Pro Asn His Tyr Gln Val Val Lys Asp Gly Leu Asn Gln Lys 
465                 470                 475                 480 


Pro Glu Lys Gly Glu Asn Gly Ile Arg Phe Val Asn Thr Phe Asn Glu 
                485                 490                 495     


Leu Ile Thr Ile Thr Met Ser Gly Lys Val Tyr Ala Asn Ile Ser Ser 
            500                 505                 510         


Tyr Asn Ala Ser Thr Tyr Gln Phe Phe Pro Ser Gly Ile Lys Gly Phe 
        515                 520                 525             


Thr Ile Ser Ser Thr Glu Ile Pro Pro Gln Cys Gln Pro Asn Phe Asn 
    530                 535                 540                 


Thr Phe Tyr Leu Glu Phe Gly Ser Ala Tyr Thr Tyr Ile Val Gln Arg 
545                 550                 555                 560 


Lys Asn Asp Ser Cys Pro Glu Val Lys Val Phe Glu Asp Ile Ser Ala 
                565                 570                 575     


Asn Thr Val Asn Met Ala Leu Gln Ile Pro Gln Tyr Phe Leu Leu Thr 
            580                 585                 590         


Cys Gly Glu Val Val Phe Ser Val Thr Gly Leu Glu Phe Ser Tyr Ser 
        595                 600                 605             


Gln Ala Pro Ser Asn Met Lys Ser Val Leu Gln Ala Gly Trp Leu Leu 
    610                 615                 620                 


Thr Val Ala Val Gly Asn Ile Ile Val Leu Ile Val Ala Gly Ala Gly 
625                 630                 635                 640 


Gln Phe Ser Lys Gln Trp Ala Glu Tyr Ile Leu Phe Ala Ala Leu Leu 
                645                 650                 655     


Leu Val Val Cys Val Ile Phe Ala Ile Met Ala Arg Phe Tyr Thr Tyr 
            660                 665                 670         


Ile Asn Pro Ala Glu Ile Glu Ala Gln Phe Asp Glu Asp Glu Lys Lys 
        675                 680                 685             


Asn Arg Leu Glu Lys Ser Asn Pro Tyr Phe Met Ser Gly Ala Asn Ser 
    690                 695                 700                 


Gln Lys Gln Met 
705             


<210>  1213
<211>  7522
<212>  DNA
<213>  Homosapiens

<400>  1213
gcggccgggc cgggccgcgg gagcaggcgg aggcggaggc ggcgggggca ggaggatgtc     60

gcagccgccg ctgctccccg cctcggcgga gactcggaag ttcacccggg cgctgagtaa    120

gccgggcacg gcggccgagc tgcggcagag cgtgtctgag gtggtgcgcg gctccgtgct    180

cctggcaaag ccaaagctaa ttgagccact cgactatgaa aatgtcatcg tccagaagaa    240

gactcagatc ctgaacgact gtttacggga gatgctgctc ttcccttacg atgactttca    300

gacggccatc ctgagacgac agggtcgata catatgctca acagtgcctg cgaaggcgga    360

agaggaagca cagagcttgt ttgttacaga gtgcatcaaa acctataact ctgactggca    420

tcttgtgaac tataaatatg aagattactc aggagagttt cgacagcttc cgaacaaagt    480

ggtcaagttg gataaacttc cagttcatgt ctatgaagtt gacgaggagg tcgacaaaga    540

tgaggatgct gcctcccttg gttcccagaa gggtgggatc accaagcatg gctggctgta    600

caaaggcaac atgaacagtg ccatcagcgt gaccatgagg tcatttaaga gacgattttt    660

ccacctgatt caacttggcg atggatccta taatttgaat ttttataaag atgaaaagat    720

ctccaaagaa ccaaaaggat caatatttct ggattcctgt atgggtgtcg ttcagaacaa    780

caaagtcagg cgttttgctt ttgagctcaa gatgcaggac aaaagtagtt atctcttggc    840

agcagacagt gaagtggaaa tggaagaatg gatcacaatt ctaaataaga tcctccagct    900

caactttgaa gctgcaatgc aagaaaagcg aaatggcgac tctcacgaag atgatgaaca    960

aagcaaattg gaaggttctg gttccggttt agatagctac ctgccggaac ttgccaagag   1020

tgcaagagaa gcagaaatca aactgaaaag tgaaagcaga gtcaaacttt tttatttgga   1080

cccagatgcc cagaagcttg acttctcatc agctgagcca gaagtgaagt catttgaaga   1140

gaagtttgga aaaaggatcc ttgtcaagtg caatgattta tctttcaatt tgcaatgctg   1200

tgttgccgaa aatgaagaag gacccactac aaatgttgaa cctttctttg ttactctatc   1260

cctgtttgac ataaaataca accggaagat ttctgccgat ttccacgtag acctgaacca   1320

tttctcagtg aggcaaatgc tcgccaccac gtccccggcg ctgatgaatg gcagtgggca   1380

gagcccatct gtcctcaagg gcatccttca tgaagccgcc atgcagtatc cgaagcaggg   1440

aatattttca gtcacttgtc ctcatccaga tatatttctt gtggccagaa ttgaaaaagt   1500

ccttcagggg agcatcacac attgcgctga gccatatatg aaaagttcag actcttctaa   1560

ggtggcccag aaggtgctga agaatgccaa gcaggcatgc caaagactag gacagtatag   1620

aatgccattt gcttgggcag caaggacatt gtttaaggat gcatctggaa atcttgacaa   1680

aaatgccaga ttttctgcca tctacaggca agacagcaat aagctatcca atgatgacat   1740

gctcaagtta cttgcagact ttcggaaacc tgagaagatg gctaagctcc cagtgatttt   1800

aggcaatcta gacattacaa ttgataatgt ttcctcagac ttccctaatt atgttaattc   1860

atcatacatt cccacaaaac aatttgaaac ctgcagtaaa actcccatca cgtttgaagt   1920

ggaggaattt gtgccctgca taccaaaaca cactcagcct tacaccatct acaccaatca   1980

cctttacgtt tatcctaagt acttgaaata cgacagtcag aagtcttttg ccaaggctag   2040

aaatattgcg atttgcattg aattcaaaga ttcagatgag gaagactctc agccccttaa   2100

gtgcatttat ggcagacctg gtgggccagt tttcacaaga agcgcctttg ctgcagtttt   2160

acaccatcac caaaacccag aattttatga tgagattaaa atagagttgc ccactcagct   2220

gcatgaaaag caccacctgt tgctcacatt cttccatgtc agctgtgaca actcaagtaa   2280

aggaagcacg aagaagaggg atgtcgttga aacccaagtt ggctactcct ggcttcccct   2340

cctgaaagac ggaagggtgg tgacaagcga gcagcacatc ccggtctcgg cgaaccttcc   2400

ttcgggctat cttggctacc aggagcttgg gatgggcagg cattatggtc cggaaattaa   2460

atgggtagat ggaggcaagc cactgctgaa aatttccact catctggttt ctacagtgta   2520

tactcaggat cagcatttac ataatttttt ccagtactgt cagaaaaccg aatctggagc   2580

ccaagcctta ggaaacgaac ttgtaaagta ccttaagagt ctgcatgcga tggaaggcca   2640

cgtgatgatc gccttcttgc ccactatcct aaaccagctg ttccgagtcc tcaccagagc   2700

cacacaggaa gaagtcgcgg ttaacgtgac tcgggtcatt attcatgtgg ttgcccagtg   2760

ccatgaggaa ggattggaga gccacttgag gtcatatgtt aagtacgcgt ataaggctga   2820

gccatatgtt gcctctgaat acaagacagt gcatgaagaa ctgaccaaat ccatgaccac   2880

gattctcaag ccttctgccg atttcctcac cagcaacaaa ctactgaagt actcatggtt   2940

tttctttgat gtactgatca aatctatggc tcagcatttg atagagaact ccaaagttaa   3000

gttgctgcga aaccagagat ttcctgcatc ctatcatcat gcagtggaaa ccgttgtaaa   3060

tatgctgatg ccacacatca ctcagaagtt tcgagataat ccagaggcat ctaagaacgc   3120

gaatcatagc cttgctgtct tcatcaagag atgtttcacc ttcatggaca ggggctttgt   3180

cttcaagcag atcaacaact acattagctg ttttgctcct ggagacccaa agaccctctt   3240

tgaatacaag tttgaatttc tccgtgtagt gtgcaaccat gaacattata ttccgttgaa   3300

cttaccaatg ccatttggaa aaggcaggat tcaaagatac caagacctcc agcttgacta   3360

ctcattaaca gatgagttct gcagaaacca cttcttggtg ggactgttac tgagggaggt   3420

ggggacagcc ctccaggagt tccgggaggt ccgtctgatc gccatcagtg tgctcaagaa   3480

cctgctgata aagcattctt ttgatgacag atatgcttca aggagccatc aggcaaggat   3540

agccaccctc tacctgcctc tgtttggtct gctgattgaa aacgtccagc ggatcaatgt   3600

gagggatgtg tcacccttcc ctgtgaacgc gggcatgact gtgaaggatg aatccctggc   3660

tctaccagct gtgaatccgc tggtgacgcc gcagaaggga agcaccctgg acaacagcct   3720

gcacaaggac ctgctgggcg ccatctccgg cattgcttct ccatatacaa cctcaactcc   3780

aaacatcaac agtgtgagaa atgctgattc gagaggatct ctcataagca cagattcggg   3840

taacagcctt ccagaaagga atagtgagaa gagcaattcc ctggataagc accaacaaag   3900

tagcacattg ggaaattccg tggttcgctg tgataaactt gaccagtctg agattaagag   3960

cctactgatg tgtttcctct acatcttaaa gagcatgtct gatgatgctt tgtttacata   4020

ttggaacaag gcttcaacat ctgaacttat ggattttttt acaatatctg aagtctgcct   4080

gcaccagttc cagtacatgg ggaagcgata catagccaga acaggaatga tgcatgccag   4140

attgcagcag ctgggcagcc tggataactc tctcactttt aaccacagct atggccactc   4200

ggacgcagat gttctgcacc agtcattact tgaagccaac attgctactg aggtttgcct   4260

gacagctctg gacacgcttt ctctatttac attggcgttt aagaaccagc tcctggccga   4320

ccatggacat aatcctctca tgaaaaaagt ttttgatgtc tacctgtgtt ttcttcaaaa   4380

acatcagtct gaaacggctt taaaaaatgt cttcactgcc ttaaggtcct taatttataa   4440

gtttccctca acattctatg aagggagagc ggacatgtgt gcggctctgt gttacgagat   4500

tctcaagtgc tgtaactcca agctgagctc catcaggacg gaggcctccc agctgctcta   4560

cttcctgatg aggaacaact ttgattacac tggaaagaag tcctttgtcc ggacacattt   4620

gcaagtcatc atatctgtca gccagctgat agcagacgtt gttggcattg ggggaaccag   4680

attccagcag tccctgtcca tcatcaacaa ctgtgccaac agtgaccggc ttattaagca   4740

caccagcttc tcctctgatg tgaaggactt aaccaaaagg atacgcacgg tgctaatggc   4800

caccgcccag atgaaggagc atgagaacga cccagagatg ctggtggacc tccagtacag   4860

cctggccaaa tcctatgcca gcacgcccga gctcaggaag acgtggctcg acagcatggc   4920

caggatccat gtcaaaaatg gcgatctctc agaggcagca atgtgctatg tccacgtaac   4980

agccctagtg gcagaatatc tcacacggaa agaagcagtc cagtgggagc cgccccttct   5040

cccccacagc catagcgcct gcctgaggag gagccgggga ggcgtgttta gacaaggatg   5100

caccgccttc agggtcatta ccccaaacat cgacgaggag gcctccatga tggaagacgt   5160

ggggatgcag gatgtccatt tcaacgagga tgtgctgatg gagctccttg agcagtgcgc   5220

agatggactc tggaaagccg agcgctacga gctcattgcc gacatctaca aacttatcat   5280

ccccatttat gagaagcgga gggattttga gaggctggcc catctgtatg acacgctgca   5340

ccgggcctac agcaaagtga ccgaggtcat gcactcgggc cgcaggcttc tggggaccta   5400

cttccgggta gccttcttcg ggcaggcagc gcaataccag tttacagaca gtgaaacaga   5460

tgtggaggga ttctttgaag atgaagatgg aaaggagtat atttacaagg aacccaaact   5520

cacaccgctg tcggaaattt ctcagagact ccttaaactg tactcggata aatttggttc   5580

tgaaaatgtc aaaatgatac aggattctgg caaggtcaac cctaaggatc tggattctaa   5640

gtatgcctac atccaggtga ctcacgtcat ccccttcttt gacgaaaaag agttgcaaga   5700

aaggaaaaca gagtttgaga gatcccacaa catccgccgc ttcatgtttg agatgccatt   5760

tacgcagacc gggaagaggc agggcggggt ggaagagcag tgcaaacggc gcaccatcct   5820

gacagccata cactgcttcc cttatgtgaa gaagcgcatc cctgtcatgt accagcacca   5880

cactgacctg aaccccatcg aggtggccat tgacgagatg agtaagaagg tggcggagct   5940

ccggcagctg tgctcctcgg ccgaggtgga catgatcaaa ctgcagctca aactccaggg   6000

cagcgtgagt gttcaggtca atgctggccc actagcatat gcgcgagctt tcttagatga   6060

tacaaacaca aagcgatatc ctgacaataa agtgaagctg cttaaggaag ttttcaggca   6120

atttgtggaa gcttgcggtc aagccttagc ggtaaacgaa cgtctgatta aagaagacca   6180

gctcgagtat caggaagaaa tgaaagccaa ctacagggaa atggcgaagg agctttctga   6240

aatcatgcat gagcagctgg gatgatctgc cccctggagg agaagacgag cgtcttaccg   6300

aattcccttc acatcttcaa cgccatcagt gggactccaa caagcacaat ggttcacggg   6360

atgaccagct cgtcttcggt cgtgtgatta catctcatgg cccgtgtgtg gggacttgct   6420

ttgtcatttg caaactcagg atgctttcca aagccaatca ctggggagac cgagcacagg   6480

gaggaccagg ggaaggggag agaaaggaaa taaagaacaa cgttatttct taacagactt   6540

tctataggag ttgtaagaag gtgcacatat ttttttaaat ctcactggca atattcaaag   6600

ttttcattgt gtcttaacaa aggtgtggta gacactcttg agctggactt agattttatt   6660

cttccttgca gagtagtgtt agaatagatg gcctacagaa aaaaaaggtt ctgggatcta   6720

catggcaggg agggctgcac tgacattgat gcctggggga ccttttgcct cgaggctgag   6780

ctggaaaatc ttgaaaatat tttttttttc ctgtggcaca ttcaggttga atacaagaac   6840

tatttttgtg actagttttt gatgacctaa gggaactgac cattgtaatt tttgtaccag   6900

tgaaccagga gatttagtgc ttttatattc atttccttgc atttaagaaa atatgaaagc   6960

ttaaggaatt atgtgagctt aaaactagtc aagcagttta gaaccaaagg cctatattaa   7020

taaccgcaac tatgctgaaa agtacaaagt agtacagtat attgttatgt acatatcatt   7080

gttaatacag tcctggcatt ctgtacatat atgtattaca tttctacatt tttaatactc   7140

acatgggctt atgcattaag tttaattgtg ataaatttgt gctgttccag tatatgcaat   7200

acactttaat gttttattct tgtacataaa aatgtgcaat atggagatgt atacagtctt   7260

tactatatta ggtttataaa cagttttaag aatttcatcc ttttgccaaa atggtggagt   7320

atgtaattgg taaatcataa atcctgtggt gaatggtggt gtactttaaa gctgtcacca   7380

tgttatattt tcttttaaga cattaattta gtaattttat atttgggaaa ataaaggttt   7440

ttaattttat ttaactggaa tcactgccct gctgtaatta aacattctgt accacatctg   7500

tattaaaaag acattgctga cc                                            7522


<210>  1214
<211>  2069
<212>  PRT
<213>  Homosapiens

<400>  1214

Met Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe 
1               5                   10                  15      


Thr Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser 
            20                  25                  30          


Val Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu 
        35                  40                  45              


Ile Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln 
    50                  55                  60                  


Ile Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp 
65                  70                  75                  80  


Phe Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr 
                85                  90                  95      


Val Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu 
            100                 105                 110         


Cys Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr 
        115                 120                 125             


Glu Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys 
    130                 135                 140                 


Leu Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp 
145                 150                 155                 160 


Lys Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr 
                165                 170                 175     


Lys His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val 
            180                 185                 190         


Thr Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly 
        195                 200                 205             


Asp Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys 
    210                 215                 220                 


Glu Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln 
225                 230                 235                 240 


Asn Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys 
                245                 250                 255     


Ser Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp 
            260                 265                 270         


Ile Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met 
        275                 280                 285             


Gln Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys 
    290                 295                 300                 


Leu Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala 
305                 310                 315                 320 


Lys Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val 
                325                 330                 335     


Lys Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser 
            340                 345                 350         


Ala Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile 
        355                 360                 365             


Leu Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala 
    370                 375                 380                 


Glu Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr 
385                 390                 395                 400 


Leu Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe 
                405                 410                 415     


His Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr 
            420                 425                 430         


Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys 
        435                 440                 445             


Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe 
    450                 455                 460                 


Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu 
465                 470                 475                 480 


Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys 
                485                 490                 495     


Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys 
            500                 505                 510         


Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala 
        515                 520                 525             


Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala 
    530                 535                 540                 


Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp 
545                 550                 555                 560 


Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala 
                565                 570                 575     


Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val 
            580                 585                 590         


Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys 
        595                 600                 605             


Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu 
    610                 615                 620                 


Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr 
625                 630                 635                 640 


Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys 
                645                 650                 655     


Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp 
            660                 665                 670         


Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro 
        675                 680                 685             


Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His 
    690                 695                 700                 


His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr 
705                 710                 715                 720 


Gln Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser 
                725                 730                 735     


Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu 
            740                 745                 750         


Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val 
        755                 760                 765             


Val Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly 
    770                 775                 780                 


Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu 
785                 790                 795                 800 


Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His 
                805                 810                 815     


Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe 
            820                 825                 830         


Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu 
        835                 840                 845             


Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met 
    850                 855                 860                 


Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr 
865                 870                 875                 880 


Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile 
                885                 890                 895     


His Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg 
            900                 905                 910         


Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu 
        915                 920                 925             


Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu 
    930                 935                 940                 


Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser 
945                 950                 955                 960 


Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile 
                965                 970                 975     


Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser 
            980                 985                 990         


Tyr His His Ala Val Glu Thr Val  Val Asn Met Leu Met  Pro His Ile 
        995                 1000                 1005             


Thr Gln  Lys Phe Arg Asp Asn  Pro Glu Ala Ser Lys  Asn Ala Asn 
    1010                 1015                 1020             


His Ser  Leu Ala Val Phe Ile  Lys Arg Cys Phe Thr  Phe Met Asp 
    1025                 1030                 1035             


Arg Gly  Phe Val Phe Lys Gln  Ile Asn Asn Tyr Ile  Ser Cys Phe 
    1040                 1045                 1050             


Ala Pro  Gly Asp Pro Lys Thr  Leu Phe Glu Tyr Lys  Phe Glu Phe 
    1055                 1060                 1065             


Leu Arg  Val Val Cys Asn His  Glu His Tyr Ile Pro  Leu Asn Leu 
    1070                 1075                 1080             


Pro Met  Pro Phe Gly Lys Gly  Arg Ile Gln Arg Tyr  Gln Asp Leu 
    1085                 1090                 1095             


Gln Leu  Asp Tyr Ser Leu Thr  Asp Glu Phe Cys Arg  Asn His Phe 
    1100                 1105                 1110             


Leu Val  Gly Leu Leu Leu Arg  Glu Val Gly Thr Ala  Leu Gln Glu 
    1115                 1120                 1125             


Phe Arg  Glu Val Arg Leu Ile  Ala Ile Ser Val Leu  Lys Asn Leu 
    1130                 1135                 1140             


Leu Ile  Lys His Ser Phe Asp  Asp Arg Tyr Ala Ser  Arg Ser His 
    1145                 1150                 1155             


Gln Ala  Arg Ile Ala Thr Leu  Tyr Leu Pro Leu Phe  Gly Leu Leu 
    1160                 1165                 1170             


Ile Glu  Asn Val Gln Arg Ile  Asn Val Arg Asp Val  Ser Pro Phe 
    1175                 1180                 1185             


Pro Val  Asn Ala Gly Met Thr  Val Lys Asp Glu Ser  Leu Ala Leu 
    1190                 1195                 1200             


Pro Ala  Val Asn Pro Leu Val  Thr Pro Gln Lys Gly  Ser Thr Leu 
    1205                 1210                 1215             


Asp Asn  Ser Leu His Lys Asp  Leu Leu Gly Ala Ile  Ser Gly Ile 
    1220                 1225                 1230             


Ala Ser  Pro Tyr Thr Thr Ser  Thr Pro Asn Ile Asn  Ser Val Arg 
    1235                 1240                 1245             


Asn Ala  Asp Ser Arg Gly Ser  Leu Ile Ser Thr Asp  Ser Gly Asn 
    1250                 1255                 1260             


Ser Leu  Pro Glu Arg Asn Ser  Glu Lys Ser Asn Ser  Leu Asp Lys 
    1265                 1270                 1275             


His Gln  Gln Ser Ser Thr Leu  Gly Asn Ser Val Val  Arg Cys Asp 
    1280                 1285                 1290             


Lys Leu  Asp Gln Ser Glu Ile  Lys Ser Leu Leu Met  Cys Phe Leu 
    1295                 1300                 1305             


Tyr Ile  Leu Lys Ser Met Ser  Asp Asp Ala Leu Phe  Thr Tyr Trp 
    1310                 1315                 1320             


Asn Lys  Ala Ser Thr Ser Glu  Leu Met Asp Phe Phe  Thr Ile Ser 
    1325                 1330                 1335             


Glu Val  Cys Leu His Gln Phe  Gln Tyr Met Gly Lys  Arg Tyr Ile 
    1340                 1345                 1350             


Ala Arg  Thr Gly Met Met His  Ala Arg Leu Gln Gln  Leu Gly Ser 
    1355                 1360                 1365             


Leu Asp  Asn Ser Leu Thr Phe  Asn His Ser Tyr Gly  His Ser Asp 
    1370                 1375                 1380             


Ala Asp  Val Leu His Gln Ser  Leu Leu Glu Ala Asn  Ile Ala Thr 
    1385                 1390                 1395             


Glu Val  Cys Leu Thr Ala Leu  Asp Thr Leu Ser Leu  Phe Thr Leu 
    1400                 1405                 1410             


Ala Phe  Lys Asn Gln Leu Leu  Ala Asp His Gly His  Asn Pro Leu 
    1415                 1420                 1425             


Met Lys  Lys Val Phe Asp Val  Tyr Leu Cys Phe Leu  Gln Lys His 
    1430                 1435                 1440             


Gln Ser  Glu Thr Ala Leu Lys  Asn Val Phe Thr Ala  Leu Arg Ser 
    1445                 1450                 1455             


Leu Ile  Tyr Lys Phe Pro Ser  Thr Phe Tyr Glu Gly  Arg Ala Asp 
    1460                 1465                 1470             


Met Cys  Ala Ala Leu Cys Tyr  Glu Ile Leu Lys Cys  Cys Asn Ser 
    1475                 1480                 1485             


Lys Leu  Ser Ser Ile Arg Thr  Glu Ala Ser Gln Leu  Leu Tyr Phe 
    1490                 1495                 1500             


Leu Met  Arg Asn Asn Phe Asp  Tyr Thr Gly Lys Lys  Ser Phe Val 
    1505                 1510                 1515             


Arg Thr  His Leu Gln Val Ile  Ile Ser Val Ser Gln  Leu Ile Ala 
    1520                 1525                 1530             


Asp Val  Val Gly Ile Gly Gly  Thr Arg Phe Gln Gln  Ser Leu Ser 
    1535                 1540                 1545             


Ile Ile  Asn Asn Cys Ala Asn  Ser Asp Arg Leu Ile  Lys His Thr 
    1550                 1555                 1560             


Ser Phe  Ser Ser Asp Val Lys  Asp Leu Thr Lys Arg  Ile Arg Thr 
    1565                 1570                 1575             


Val Leu  Met Ala Thr Ala Gln  Met Lys Glu His Glu  Asn Asp Pro 
    1580                 1585                 1590             


Glu Met  Leu Val Asp Leu Gln  Tyr Ser Leu Ala Lys  Ser Tyr Ala 
    1595                 1600                 1605             


Ser Thr  Pro Glu Leu Arg Lys  Thr Trp Leu Asp Ser  Met Ala Arg 
    1610                 1615                 1620             


Ile His  Val Lys Asn Gly Asp  Leu Ser Glu Ala Ala  Met Cys Tyr 
    1625                 1630                 1635             


Val His  Val Thr Ala Leu Val  Ala Glu Tyr Leu Thr  Arg Lys Glu 
    1640                 1645                 1650             


Ala Val  Gln Trp Glu Pro Pro  Leu Leu Pro His Ser  His Ser Ala 
    1655                 1660                 1665             


Cys Leu  Arg Arg Ser Arg Gly  Gly Val Phe Arg Gln  Gly Cys Thr 
    1670                 1675                 1680             


Ala Phe  Arg Val Ile Thr Pro  Asn Ile Asp Glu Glu  Ala Ser Met 
    1685                 1690                 1695             


Met Glu  Asp Val Gly Met Gln  Asp Val His Phe Asn  Glu Asp Val 
    1700                 1705                 1710             


Leu Met  Glu Leu Leu Glu Gln  Cys Ala Asp Gly Leu  Trp Lys Ala 
    1715                 1720                 1725             


Glu Arg  Tyr Glu Leu Ile Ala  Asp Ile Tyr Lys Leu  Ile Ile Pro 
    1730                 1735                 1740             


Ile Tyr  Glu Lys Arg Arg Asp  Phe Glu Arg Leu Ala  His Leu Tyr 
    1745                 1750                 1755             


Asp Thr  Leu His Arg Ala Tyr  Ser Lys Val Thr Glu  Val Met His 
    1760                 1765                 1770             


Ser Gly  Arg Arg Leu Leu Gly  Thr Tyr Phe Arg Val  Ala Phe Phe 
    1775                 1780                 1785             


Gly Gln  Ala Ala Gln Tyr Gln  Phe Thr Asp Ser Glu  Thr Asp Val 
    1790                 1795                 1800             


Glu Gly  Phe Phe Glu Asp Glu  Asp Gly Lys Glu Tyr  Ile Tyr Lys 
    1805                 1810                 1815             


Glu Pro  Lys Leu Thr Pro Leu  Ser Glu Ile Ser Gln  Arg Leu Leu 
    1820                 1825                 1830             


Lys Leu  Tyr Ser Asp Lys Phe  Gly Ser Glu Asn Val  Lys Met Ile 
    1835                 1840                 1845             


Gln Asp  Ser Gly Lys Val Asn  Pro Lys Asp Leu Asp  Ser Lys Tyr 
    1850                 1855                 1860             


Ala Tyr  Ile Gln Val Thr His  Val Ile Pro Phe Phe  Asp Glu Lys 
    1865                 1870                 1875             


Glu Leu  Gln Glu Arg Lys Thr  Glu Phe Glu Arg Ser  His Asn Ile 
    1880                 1885                 1890             


Arg Arg  Phe Met Phe Glu Met  Pro Phe Thr Gln Thr  Gly Lys Arg 
    1895                 1900                 1905             


Gln Gly  Gly Val Glu Glu Gln  Cys Lys Arg Arg Thr  Ile Leu Thr 
    1910                 1915                 1920             


Ala Ile  His Cys Phe Pro Tyr  Val Lys Lys Arg Ile  Pro Val Met 
    1925                 1930                 1935             


Tyr Gln  His His Thr Asp Leu  Asn Pro Ile Glu Val  Ala Ile Asp 
    1940                 1945                 1950             


Glu Met  Ser Lys Lys Val Ala  Glu Leu Arg Gln Leu  Cys Ser Ser 
    1955                 1960                 1965             


Ala Glu  Val Asp Met Ile Lys  Leu Gln Leu Lys Leu  Gln Gly Ser 
    1970                 1975                 1980             


Val Ser  Val Gln Val Asn Ala  Gly Pro Leu Ala Tyr  Ala Arg Ala 
    1985                 1990                 1995             


Phe Leu  Asp Asp Thr Asn Thr  Lys Arg Tyr Pro Asp  Asn Lys Val 
    2000                 2005                 2010             


Lys Leu  Leu Lys Glu Val Phe  Arg Gln Phe Val Glu  Ala Cys Gly 
    2015                 2020                 2025             


Gln Ala  Leu Ala Val Asn Glu  Arg Leu Ile Lys Glu  Asp Gln Leu 
    2030                 2035                 2040             


Glu Tyr  Gln Glu Glu Met Lys  Ala Asn Tyr Arg Glu  Met Ala Lys 
    2045                 2050                 2055             


Glu Leu  Ser Glu Ile Met His  Glu Gln Leu Gly 
    2060                 2065                 


<210>  1215
<211>  2498
<212>  DNA
<213>  Homosapiens

<400>  1215
accagcaccc cgcccagagc agtgccgctg cccaaatcct cgcaggcagc tcatcaacgc     60

aattgcaact ccggctggag ccccggacct gcaagcctgg gtgtccgtgg gtccgtctgc    120

ccagccatct gctggtggca cctctccctc ctgccgcctc cctcggtgaa ccccaccttg    180

cagaagtgca gctcgcccgg agcagcccag gagctcagca tgcgtccccc aggcttcagg    240

aacttcttgc tgctggcgtc ctcccttctc tttgctgggt tgtcagctgt tcctcaaagc    300

ttctcgccat ctctgaggag ctggccgggc gccgcctgca ggctgtcccg ggccgagtcg    360

gagcgacgct gccgcgcacc tgggcagccc ccgggggccg cgctgtgcca cggccggggc    420

cgctgcgact gcggcgtctg catctgccac gtgactgagc cgggcatgtt cttcgggccc    480

ctgtgtgagt gccatgagtg ggtgtgcgag acctacgacg ggagcacctg tgcaggccat    540

ggtaagtgtg actgtggcaa gtgcaagtgt gaccagggat ggtatgggga tgcttgccag    600

tacccaacta actgtgactt gacaaagaag aaaagtaacc aaatgtgcaa gaattcacaa    660

gacatcatct gctctaatgc aggtacatgt cactgtggca ggtgtaagtg tgataattca    720

gatggaagtg gacttgtgta tggtaaattt tgtgagtgtg acgatagaga atgcatagac    780

gatgaaacag aagaaatatg tggaggccat gggaagtgtt actgtggaaa ctgctactgc    840

aaggctggtt ggcatggaga taaatgtgaa ttccagtgcg atatcacccc ctgggaaagc    900

aagcgaagat gcacgtctcc agatggcaaa atctgcagta acagagggac ttgtgtatgt    960

ggtgaatgta cctgtcacga tgttgatccg actggggact ggggagatat tcatggggac   1020

acctgtgaat gtgatgagag ggactgtaga gctgtctatg accgatattc tgatgacttc   1080

tgttcaggtc atggacagtg taattgcgga agatgtgact gcaaagcagg ctggtatggg   1140

aagaagtgtg agcacccaca gtcctgcacg ctgtcagctg aggagagcat caggaagtgc   1200

cagggaagct cggatctgcc ttgctctggg aggggtaaat gtgaatgtgg caaatgcacc   1260

tgctatcctc caggagatcg ccgggtgtat ggcaagactt gtgagtgtga tgatcgccgc   1320

tgtgaagacc tcgatggtgt ggtctgtgga ggccacggca catgttcctg tggtcgctgt   1380

gtttgtgaga gaggatggtt tggaaagctc tgccaacatc cgcggaagtg taacatgacg   1440

gaagaacaaa gcaagaatct gtgtgaatca gcagatggca tattgtgctc ggggaagggt   1500

tcttgtcatt gtgggaagtg catttgttct gctgaagagt ggtatatttc tggggagttc   1560

tgtgactgtg atgacagaga ctgcgacaaa catgatggtc tcatttgtac agggaatgga   1620

atatgtagct gtggaaactg tgaatgctgg gatggatgga atggaaatgc atgtgaaatc   1680

tggcttggct cagaatatcc ttaacaatta catgagagag gtctggattc ttattttttc   1740

tgggccatta gaacatataa atgcgaagga aaccatgtat attcaccact aggacaggtt   1800

aaaaagacca ttgtatgttt ttctatttct gaattacgaa tgaaatccga gtacctatta   1860

gaaatgagtt atgcaaattt agatgcaaat aacattagaa aaaaaagatt cttccataat   1920

taacataagt ggttcctaac gagagcaatt tttccaccca aaagtcattt ggcaacatct   1980

acagacaatt ttgattgtca cactgggtcg ggtaggaagg tatgctgcag acatttggtg   2040

ggtagaggcc agggatgctg ctgagcatcc cgcagtgtac aggacagccc ccaaacaagg   2100

aattatccag ccccaaatgc caatagggct cagactgaga aacattgagt tatatggcta   2160

ttagaaatcc acattcttac acaagaaaga ccatattaga atctaaggaa aacatgcata   2220

ttcacattaa ttaatcgatc agatttttcc agaattccgt atcagtcacc attttaatat   2280

ggggacaatg aagacaagca cacaggaggt agaatatcag agtggggctg gatcaagggc   2340

aaaaactggt cattaagtca tctgacatta aatcatttag ccactaagtt atttgtgtac   2400

tctcacttta aactcaccaa agaagattct cttaaagaaa ttatgaaaaa tgtacaattt   2460

aacattttaa ataaatagtg acagaagttg tttaaaaa                           2498


<210>  1216
<211>  494
<212>  PRT
<213>  Homosapiens

<400>  1216

Met Arg Pro Pro Gly Phe Arg Asn Phe Leu Leu Leu Ala Ser Ser Leu 
1               5                   10                  15      


Leu Phe Ala Gly Leu Ser Ala Val Pro Gln Ser Phe Ser Pro Ser Leu 
            20                  25                  30          


Arg Ser Trp Pro Gly Ala Ala Cys Arg Leu Ser Arg Ala Glu Ser Glu 
        35                  40                  45              


Arg Arg Cys Arg Ala Pro Gly Gln Pro Pro Gly Ala Ala Leu Cys His 
    50                  55                  60                  


Gly Arg Gly Arg Cys Asp Cys Gly Val Cys Ile Cys His Val Thr Glu 
65                  70                  75                  80  


Pro Gly Met Phe Phe Gly Pro Leu Cys Glu Cys His Glu Trp Val Cys 
                85                  90                  95      


Glu Thr Tyr Asp Gly Ser Thr Cys Ala Gly His Gly Lys Cys Asp Cys 
            100                 105                 110         


Gly Lys Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala Cys Gln Tyr 
        115                 120                 125             


Pro Thr Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln Met Cys Lys 
    130                 135                 140                 


Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys His Cys Gly 
145                 150                 155                 160 


Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val Tyr Gly Lys 
                165                 170                 175     


Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu Thr Glu Glu 
            180                 185                 190         


Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys Tyr Cys Lys 
        195                 200                 205             


Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp Ile Thr Pro 
    210                 215                 220                 


Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys Ile Cys Ser 
225                 230                 235                 240 


Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His Asp Val Asp 
                245                 250                 255     


Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys Glu Cys Asp 
            260                 265                 270         


Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp Asp Phe Cys 
        275                 280                 285             


Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys Ala Gly 
    290                 295                 300                 


Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu Ser Ala 
305                 310                 315                 320 


Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro Cys Ser 
                325                 330                 335     


Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro Pro Gly 
            340                 345                 350         


Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg Arg Cys 
        355                 360                 365             


Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys Ser Cys 
    370                 375                 380                 


Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys Gln His 
385                 390                 395                 400 


Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu Cys Glu 
                405                 410                 415     


Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His Cys Gly 
            420                 425                 430         


Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu Phe Cys 
        435                 440                 445             


Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile Cys Thr 
    450                 455                 460                 


Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp Gly Trp 
465                 470                 475                 480 


Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
                485                 490                 


<210>  1217
<211>  3721
<212>  DNA
<213>  Homosapiens

<400>  1217
atgaccgccg ctattctcca gataggaacc tggtgtcaag atacaaatac gtgtgctgac     60

gctgcgagtg tggtgtttaa aggtgatcac ggtcagctcc aggaaatcca ggtgggaaaa    120

cttaaagaga aagcccccaa gcatgttggc ttttctgttc tcctgtgctg gatcgtgtgc    180

atgttggtaa acatcatctt tcccatgtat gtgactggca aatggaacta cacaaacatc    240

acagtgaacg aggatttggg atactgttct gggggaggca acaacaaaat cgcacagaca    300

ctgcgtgcaa tgttgttatc attccctgat gtgttgtgtc tggggctcat gctctgggtc    360

agcagctcca tggtttgcat cctgcacagg cacaagcagc gggtccagca cattgatagg    420

agcgatctct cccccagagc ctccccagag aacagagcta cgcagagcat cctcatcctg    480

ggtctattga cattcaggga tgtggccata gaattctctc aggaagagtg gaagtgcctg    540

gaccctgctc agaggactct atacagggac gtgatgctgg agaattatag gaacctggtc    600

tccctgggtg aggataactt ccctccagaa gtggggatat gtcacactgg caagaaacct    660

tacaagtgta atgattgtgg caagaccttc agtcaggagt taacccttac atgccatcat    720

agacttcata ctggagagaa acattacaag tgcagtgagt gtggcaagac cttcagtcga    780

aattcagccc ttgtaattca taaggcaatt catactggag agaaatctta caagtgtaat    840

gaatgtggca agaccttcag tcaaacgtca taccttgtgt accatcgtag acttcatact    900

ggagagaaac cttacaaatg tgaagaatgt gacaaagctt tcagtttcaa atcaaacctt    960

gaaagacata ggaaaattca tactggagag aaaccttaca agtgtaatga atgcagcagg   1020

acctttagtc ggaagtcatc ccttacacgc catcgtagac ttcatactgg agagaaacct   1080

tataagtgta atgattgtgg caagaccttc agtcagatgt catcccttgt ataccatcgt   1140

agacttcata ctggagagaa accttacaaa tgtgaagaat gtgatgaagc tttcagtttc   1200

aaatcgaacc ttgaaagaca taggagaatt catactggag agaaacctta caagtgtaat   1260

gattgtggca agaccttcag tcagacatca tcccttgtat accatcgtag acttcatact   1320

ggagagaaac cttacaaatg tgaagaatgt gatgaagctt tcagtttcaa atcaaacctt   1380

gaaagacata ggataattca tactggagag aaactttaca agtgtaatga atgtggcaag   1440

acctttagtc ggaagtcatc ccttacacgc cattgtagac ttcatactgg agagaaacct   1500

taccagtgta atgagtgtgg caaagccttt cgtgggcagt cagcacttat ttaccatcaa   1560

gcaatccatg gtatagggaa actttacaaa tgtaatgatt gtcaccaagt ctttagtaat   1620

gctacaacca ttgcaaatca ttggagaatc cataatgaag agagatcgta caagtgtaat   1680

agatgtggca aatttttcag acatcgttca taccttgcag ttcattggcg aactcatagt   1740

ggagagaaac cttacaaatg tgaagaatgt gatgaagctt tcagtttcaa atcaaacctt   1800

caaagacata ggagaattca tactggagag aaaccttaca ggtgtaatga atgtggcaag   1860

acctttagtc ggaagtcata ccttacatgc catcgtagac ttcatactgg agagaaacct   1920

tacaagtgta atgagtgtgg caagaccttc ggtcgaaatt cagcccttat aattcacaag   1980

gcaattcata ctggagagaa accttacaag tgtaatgagt gtggcaaggc cttcagtcag   2040

aagtcatccc ttacatgcca tcttagactt catactggag agaaacctta caaatgtgaa   2100

gaatgtgaca aagttttcag tcgcaaatca agccttgaaa aacacaggag aattcatact   2160

ggagagaaac catacaaatg taaggtttgt gacaaagctt ttgggcgtga ttcacacctg   2220

gcacaacata ctagaattca cactggagag aaaccttaca agtgtaatga atgtggcaag   2280

aacttccgtc acaattcagc ccttgtaatt cataaggcaa ttcatagtgg agagaaacct   2340

tacaagtgta atgagtgtgg caagaccttc cgtcacaatt cagcccttga aattcataag   2400

gcaattcata ctggagaaaa accttacaag tgtagtgaat gtggcaaggt ttttaataga   2460

aaagcaaacc tttcacgtca tcatagactt catactggag agaaacctta caagtgtaat   2520

aaatgtggta aggtttttaa tcaacaagca caccttgcat gtcatcatag aattcatact   2580

ggagagaaac cttacaagtg taatgagtgt ggcaaaacct tccgtcacaa ttcagtcctt   2640

gtaattcata agacaattca tactggagag aaaccttaca agtgtaatga atgtggcaag   2700

gtttttaatc gaaaagcaaa acttgcacgt catcatagaa ttcatactgg aaagaaacat   2760

tagaaatatg aagaatgtga caaagtttac agttgtaaat caagtcttga aagacaggag   2820

aattcatact ggagagaaag cttacaaatg taagagtttg tgacaagaat cttgggcgtg   2880

attcacacct ggcccaacaa actagaagtc acactggaga gaaaccttac aagtgtactg   2940

agtgtggcaa agcctttagt gggcagtcaa cacttattca ccatcaggca atccatggta   3000

tagggaaact ttactaatgt aatgattatc acaaagtctt cagtaacact acaaccgttt   3060

caaatcattg gagaatccat aatgagagat tttgaaagtg taataaatgt ggcaaatttt   3120

tcagacattg ttcatacctt gcagttcatc ggtgaactca tgctggagag aaaccttaca   3180

aatgtcatga ttgtggcaag gtcttcagtc tagcttcatc ttatgcaaaa caggagactt   3240

catacaggag acaaacttca caagtatgat gattgcagca aagcctttac ttcacgttca   3300

cacctaatta gacatcagag aatccatact ggacagaaat cttacaaatg tcatcagtgt   3360

ggcaaggtct tcagtctgag atcacccctt aaggaacatc agaaaattca tttttgagat   3420

gattgttcca aatgcaatga gtatagcaaa ccatcaagca ttaattggca ttagagtcaa   3480

ttcagcattg acttgagttt gaattgactt aacattgagt tcaagcatta attgacatta   3540

aagtgtttat gttaagaaga ttgggccagg cggggtggct cacgcctgta atcccagcac   3600

tttgggaggc caagaccaat agatcacttg aggtcaggag tttgagacca gactggccaa   3660

cagacatgag tcacttttcc caccctgtat tttgtttctt taataaaaac tgttacgggt   3720

t                                                                   3721


<210>  1218
<211>  920
<212>  PRT
<213>  Homosapiens

<400>  1218

Met Thr Ala Ala Ile Leu Gln Ile Gly Thr Trp Cys Gln Asp Thr Asn 
1               5                   10                  15      


Thr Cys Ala Asp Ala Ala Ser Val Val Phe Lys Gly Asp His Gly Gln 
            20                  25                  30          


Leu Gln Glu Ile Gln Val Gly Lys Leu Lys Glu Lys Ala Pro Lys His 
        35                  40                  45              


Val Gly Phe Ser Val Leu Leu Cys Trp Ile Val Cys Met Leu Val Asn 
    50                  55                  60                  


Ile Ile Phe Pro Met Tyr Val Thr Gly Lys Trp Asn Tyr Thr Asn Ile 
65                  70                  75                  80  


Thr Val Asn Glu Asp Leu Gly Tyr Cys Ser Gly Gly Gly Asn Asn Lys 
                85                  90                  95      


Ile Ala Gln Thr Leu Arg Ala Met Leu Leu Ser Phe Pro Asp Val Leu 
            100                 105                 110         


Cys Leu Gly Leu Met Leu Trp Val Ser Ser Ser Met Val Cys Ile Leu 
        115                 120                 125             


His Arg His Lys Gln Arg Val Gln His Ile Asp Arg Ser Asp Leu Ser 
    130                 135                 140                 


Pro Arg Ala Ser Pro Glu Asn Arg Ala Thr Gln Ser Ile Leu Ile Leu 
145                 150                 155                 160 


Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Gln Glu Glu 
                165                 170                 175     


Trp Lys Cys Leu Asp Pro Ala Gln Arg Thr Leu Tyr Arg Asp Val Met 
            180                 185                 190         


Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu Gly Glu Asp Asn Phe Pro 
        195                 200                 205             


Pro Glu Val Gly Ile Cys His Thr Gly Lys Lys Pro Tyr Lys Cys Asn 
    210                 215                 220                 


Asp Cys Gly Lys Thr Phe Ser Gln Glu Leu Thr Leu Thr Cys His His 
225                 230                 235                 240 


Arg Leu His Thr Gly Glu Lys His Tyr Lys Cys Ser Glu Cys Gly Lys 
                245                 250                 255     


Thr Phe Ser Arg Asn Ser Ala Leu Val Ile His Lys Ala Ile His Thr 
            260                 265                 270         


Gly Glu Lys Ser Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln 
        275                 280                 285             


Thr Ser Tyr Leu Val Tyr His Arg Arg Leu His Thr Gly Glu Lys Pro 
    290                 295                 300                 


Tyr Lys Cys Glu Glu Cys Asp Lys Ala Phe Ser Phe Lys Ser Asn Leu 
305                 310                 315                 320 


Glu Arg His Arg Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn 
                325                 330                 335     


Glu Cys Ser Arg Thr Phe Ser Arg Lys Ser Ser Leu Thr Arg His Arg 
            340                 345                 350         


Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Asp Cys Gly Lys 
        355                 360                 365             


Thr Phe Ser Gln Met Ser Ser Leu Val Tyr His Arg Arg Leu His Thr 
    370                 375                 380                 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asp Glu Ala Phe Ser Phe 
385                 390                 395                 400 


Lys Ser Asn Leu Glu Arg His Arg Arg Ile His Thr Gly Glu Lys Pro 
                405                 410                 415     


Tyr Lys Cys Asn Asp Cys Gly Lys Thr Phe Ser Gln Thr Ser Ser Leu 
            420                 425                 430         


Val Tyr His Arg Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
        435                 440                 445             


Glu Cys Asp Glu Ala Phe Ser Phe Lys Ser Asn Leu Glu Arg His Arg 
    450                 455                 460                 


Ile Ile His Thr Gly Glu Lys Leu Tyr Lys Cys Asn Glu Cys Gly Lys 
465                 470                 475                 480 


Thr Phe Ser Arg Lys Ser Ser Leu Thr Arg His Cys Arg Leu His Thr 
                485                 490                 495     


Gly Glu Lys Pro Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Arg Gly 
            500                 505                 510         


Gln Ser Ala Leu Ile Tyr His Gln Ala Ile His Gly Ile Gly Lys Leu 
        515                 520                 525             


Tyr Lys Cys Asn Asp Cys His Gln Val Phe Ser Asn Ala Thr Thr Ile 
    530                 535                 540                 


Ala Asn His Trp Arg Ile His Asn Glu Glu Arg Ser Tyr Lys Cys Asn 
545                 550                 555                 560 


Arg Cys Gly Lys Phe Phe Arg His Arg Ser Tyr Leu Ala Val His Trp 
                565                 570                 575     


Arg Thr His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asp Glu 
            580                 585                 590         


Ala Phe Ser Phe Lys Ser Asn Leu Gln Arg His Arg Arg Ile His Thr 
        595                 600                 605             


Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys Gly Lys Thr Phe Ser Arg 
    610                 615                 620                 


Lys Ser Tyr Leu Thr Cys His Arg Arg Leu His Thr Gly Glu Lys Pro 
625                 630                 635                 640 


Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Gly Arg Asn Ser Ala Leu 
                645                 650                 655     


Ile Ile His Lys Ala Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn 
            660                 665                 670         


Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Ser Leu Thr Cys His Leu 
        675                 680                 685             


Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asp Lys 
    690                 695                 700                 


Val Phe Ser Arg Lys Ser Ser Leu Glu Lys His Arg Arg Ile His Thr 
705                 710                 715                 720 


Gly Glu Lys Pro Tyr Lys Cys Lys Val Cys Asp Lys Ala Phe Gly Arg 
                725                 730                 735     


Asp Ser His Leu Ala Gln His Thr Arg Ile His Thr Gly Glu Lys Pro 
            740                 745                 750         


Tyr Lys Cys Asn Glu Cys Gly Lys Asn Phe Arg His Asn Ser Ala Leu 
        755                 760                 765             


Val Ile His Lys Ala Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Asn 
    770                 775                 780                 


Glu Cys Gly Lys Thr Phe Arg His Asn Ser Ala Leu Glu Ile His Lys 
785                 790                 795                 800 


Ala Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys 
                805                 810                 815     


Val Phe Asn Arg Lys Ala Asn Leu Ser Arg His His Arg Leu His Thr 
            820                 825                 830         


Gly Glu Lys Pro Tyr Lys Cys Asn Lys Cys Gly Lys Val Phe Asn Gln 
        835                 840                 845             


Gln Ala His Leu Ala Cys His His Arg Ile His Thr Gly Glu Lys Pro 
    850                 855                 860                 


Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Arg His Asn Ser Val Leu 
865                 870                 875                 880 


Val Ile His Lys Thr Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn 
                885                 890                 895     


Glu Cys Gly Lys Val Phe Asn Arg Lys Ala Lys Leu Ala Arg His His 
            900                 905                 910         


Arg Ile His Thr Gly Lys Lys His 
        915                 920 


<210>  1219
<211>  3453
<212>  DNA
<213>  Homosapiens

<400>  1219
gctggaatta caggcatgag ccactgcacc cggctgttag tgaattctta ttcattataa     60

tgctgcatat ttttttgacc tcatacatca gaaggtatct cttccaaatg cacaatgaag    120

gagttctcat caacagcaca aggcaataca gaagtgatcc acacagggac attgcaaaga    180

catgaacgtc atcacattgg agatttttcc ttccaggaaa ttgagaaaga tattcataac    240

tttgagtttc agtggcaaga agatgaaaga aatggccatg aagcacccat gacaaaaatc    300

aaaaaattga tgggtagtac agagcaatat gatcacaggc atgctggaaa caagcctatt    360

aaatatcagc ttggatcaag ctttcattca catctgtctg aactccacat atttcagccc    420

aaagggaaaa ttaataatca agtggagaag tctatcaacg atgcttcctc ggtttcaaca    480

gcccaaagaa tttcttgtag gcccaaaacc catatatcta ataactatgg ggataatttt    540

ctgaattatt cattactcac acaaagacag gaagtacgca tgagagaaaa atctttccaa    600

tgtattgaga gtggcaaagc ctttaattat agctcactct taaggaaaca tcagattatt    660

catctaggag agaaacaata taaatgtgat gtatgtgaca aggtctttat tcggaagcga    720

taccttgcac gccatcgtag atgtcacact ggtgagaaac cttacaagtg taatgagtgt    780

ggcaagtcct tcagtcagat gtcatccctt acatatcatc atcgacttca tactggagag    840

aaaccttaca aatgtgaaga atgtgacaaa gctttcagac acaattcagc ccttcaaaga    900

cataggagaa ttcatactgg agagaaacca cataagtgta atgagtgtgg caagaccttt    960

agtcagaagt cataccttgc atgccatcgt agcattcata ctggaaagaa accttacgaa   1020

tgtgaagaat gtgacaaagc tttcagtttc aaatcaaacc ttgaaagtca taggataact   1080

catactggag agaaaccata caagtgtaat gattgtggca agaccttcag tcatatgtca   1140

acccttacat gccatcgtag acttcatact ggagagaaac cttacaagtg tgaagaatgt   1200

gatgaagctt tccgtttcaa atcaagtctt gaaagacata ggagaattca taatggagag   1260

aaactgtaca aatgtaatga gtgtggcaag accttcagtc aggagttatc ccttacctgc   1320

cattgtagac ttcatagtgg agagaaacct tgcaagtgtg gagaatgtga caaggcttac   1380

agtttcaaat aaaatcttga aatacgtcag aaaattcata ctggagagaa atgttataag   1440

tgtaatgatt gtggcaagat cttcagtcat acgtcatcca ttgtatacca tcataaattt   1500

catagtggag agaaacctta caaatgtgaa gaatgtgatg aagctttcag tttcaaatca   1560

aaccttgaaa gacataggag aattcacact ggtgagaaac cttacaggtg taataggtgt   1620

ggcaagacct tcagtcatac atcatccctt acatgccatc atagacttca tactggagag   1680

aaaccttaca aatgtgaaga atgtgatgaa actttcagat acaaatcaaa tcttgaaaga   1740

cataggagaa ttcataatgg agagaaaccg tacaagtgta atgagtgtgg caagaccttc   1800

agtcagaagt catgccttac acgccatcat agacttcata ctggaaataa atcttataag   1860

tgtaatgagt gtggcaagac cttcagtaag gagttaacac atgccatcat agacgtcata   1920

ctggagagaa accttagaag tgcaatgagt gtggcaaaac ctttcatagg cagtcagcgc   1980

ttatttacca tcaagcaatc catggcagag ggaaacttta caaatgtaat gattgtcacc   2040

acgtcttcag taatgctaca actattgcaa atcattggag aatccataat aaagagagac   2100

cttacaagtg tgataaatgt gacaaatttt tcagacatcg ttcatacctt gcagttcacg   2160

ggcgaactca tgctggagag aaaccttaca aatgtgaaga atgtgataaa gctttcagat   2220

tcaaatcaaa ccttgaaagt cataggagaa ttcatactag agagaaacct tacaagtgta   2280

atgagtgtgg taagatgttc agtcaaaatt cggcccttgt aattcataag gcaattcata   2340

ctggagagaa accttacaag tgtaatgaat gtggcaaggt ttttaatcgc aaagcaaagc   2400

ttgcatgtca tcatagactt catactggag agaacgcttg caagtgtaat aaatgtggcg   2460

aggtttttaa tcaacaagca caccttgcac gtcatcatag aactcatact ggagagaaac   2520

attacaagtg taatgagtgt ggcaagacct actctcacaa ttcagtcctt gtaattcata   2580

agacaattca cactggggag aaaccttaca agtgtaatga gtgtggcaaa accttccatc   2640

acaattcagt ccttgtaatt cataaaacaa ttcatactgg agagaaacaa gcgtaatgaa   2700

tgtggcgagg ttttcaatca acaagcacac gttgcacgtc atcatagaat tcatactgga   2760

gagaaacctt agaaatgtga agaatgtgac aaagtttaca gtcgcaaatc aaacctcgaa   2820

agacaggaga attcatactg gagagaaacc ataaaaatgt aagagttttt gacaaggctt   2880

tcggacgtga ttcacacctg gcacaacatc ccagagttca cactggagag aaaccttaca   2940

agtgtaatga gtgtgtcaaa gcctttagtg ggcagtcaac acttattcac catcaggcaa   3000

tccgtagtgt agggaaactt gactaacgta atgattctca caacgtcttc agtaatgcta   3060

caaccattgt aaatcactgg agaagccata atgaagagag atcttacaaa tgtaataatt   3120

gtggcaaatt tttcagacat cgttcataca ttgccgttca ttggcgaact catgctggag   3180

agaaatctta caatgtcatg attgtggcaa ggtcttcagt caagcttcat cttttgcaaa   3240

acaggagaat tcatacagga gagaaacctc acaagtgtga tgatcgtggc aaagccttta   3300

cttcacattc tcacctcatt agacatcaga gaatccatac tggacagaaa tcttacaaat   3360

gtcatcagtg tggcaaggtc ttcagtccga cttcactcct tgcagaatat cagaaaattc   3420

atttttcagg taattgttcc caatgcaatg aat                                3453


<210>  1220
<211>  425
<212>  PRT
<213>  Homosapiens

<400>  1220

Met Lys Glu Phe Ser Ser Thr Ala Gln Gly Asn Thr Glu Val Ile His 
1               5                   10                  15      


Thr Gly Thr Leu Gln Arg His Glu Arg His His Ile Gly Asp Phe Ser 
            20                  25                  30          


Phe Gln Glu Ile Glu Lys Asp Ile His Asn Phe Glu Phe Gln Trp Gln 
        35                  40                  45              


Glu Asp Glu Arg Asn Gly His Glu Ala Pro Met Thr Lys Ile Lys Lys 
    50                  55                  60                  


Leu Met Gly Ser Thr Glu Gln Tyr Asp His Arg His Ala Gly Asn Lys 
65                  70                  75                  80  


Pro Ile Lys Tyr Gln Leu Gly Ser Ser Phe His Ser His Leu Ser Glu 
                85                  90                  95      


Leu His Ile Phe Gln Pro Lys Gly Lys Ile Asn Asn Gln Val Glu Lys 
            100                 105                 110         


Ser Ile Asn Asp Ala Ser Ser Val Ser Thr Ala Gln Arg Ile Ser Cys 
        115                 120                 125             


Arg Pro Lys Thr His Ile Ser Asn Asn Tyr Gly Asp Asn Phe Leu Asn 
    130                 135                 140                 


Tyr Ser Leu Leu Thr Gln Arg Gln Glu Val Arg Met Arg Glu Lys Ser 
145                 150                 155                 160 


Phe Gln Cys Ile Glu Ser Gly Lys Ala Phe Asn Tyr Ser Ser Leu Leu 
                165                 170                 175     


Arg Lys His Gln Ile Ile His Leu Gly Glu Lys Gln Tyr Lys Cys Asp 
            180                 185                 190         


Val Cys Asp Lys Val Phe Ile Arg Lys Arg Tyr Leu Ala Arg His Arg 
        195                 200                 205             


Arg Cys His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
    210                 215                 220                 


Ser Phe Ser Gln Met Ser Ser Leu Thr Tyr His His Arg Leu His Thr 
225                 230                 235                 240 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asp Lys Ala Phe Arg His 
                245                 250                 255     


Asn Ser Ala Leu Gln Arg His Arg Arg Ile His Thr Gly Glu Lys Pro 
            260                 265                 270         


His Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser Tyr Leu 
        275                 280                 285             


Ala Cys His Arg Ser Ile His Thr Gly Lys Lys Pro Tyr Glu Cys Glu 
    290                 295                 300                 


Glu Cys Asp Lys Ala Phe Ser Phe Lys Ser Asn Leu Glu Ser His Arg 
305                 310                 315                 320 


Ile Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Asp Cys Gly Lys 
                325                 330                 335     


Thr Phe Ser His Met Ser Thr Leu Thr Cys His Arg Arg Leu His Thr 
            340                 345                 350         


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asp Glu Ala Phe Arg Phe 
        355                 360                 365             


Lys Ser Ser Leu Glu Arg His Arg Arg Ile His Asn Gly Glu Lys Leu 
    370                 375                 380                 


Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Glu Leu Ser Leu 
385                 390                 395                 400 


Thr Cys His Cys Arg Leu His Ser Gly Glu Lys Pro Cys Lys Cys Gly 
                405                 410                 415     


Glu Cys Asp Lys Ala Tyr Ser Phe Lys 
            420                 425 


<210>  1221
<211>  2044
<212>  DNA
<213>  Homosapiens

<400>  1221
cccaccgccg cgggattgac ttctaaagac tcttggtatg tgaggaagaa acctggaaga     60

ggaagaggaa agcaaaggag tcagggatgg ctcttcctca gggtctattg acattcaggg    120

atgtggccat agaattctct caggaggagt ggaaatgcct ggaccctgct cagaggactc    180

tatacaggga cgtgatgctg gagaattata ggaacctggt ctccctggag ttgtcagggg    240

agtgtccatt ggcagcacct gcctcctgag tgtctcccag gccatcacca tcagccccag    300

gagctcaggt gggcagagct taaagggaac gcccccaagc acgctggctc ctgtgtgttc    360

ctcagctggc tcctccctgg tcaatatcat tgttctcatg cacgtgaccg gcaagtggag    420

caacaaaaat accacgaaga caaaagatct gggatactgt tctgctgctg atcacgaggg    480

caccagagag tcgctgacgc ggcactgctg tccttccctg atgtgatctg cctggggctc    540

atgctctggg gcagcagctc catcgtttgc atcctgcaca ggcacaagcg gcgggtccag    600

cacattcata ggaccagcgt gtcccccaca tcctcccctg agtccggagc taccaaaacc    660

atcctcctgg agcaggaaag gacaaggagt ccccgaagct gacactgagt tcatggggtt    720

gagctgacag cggccaacag gctgtgatgg gatctcactc tgtcggccag gctggaatgc    780

aatggtgcca acttggctca gtgcaacctc cccaccccgg gctccaacaa tcctcccatc    840

tcagcctctg aagtagctgg gactacaggc gttatctcct gtccggggaa gaggtgggcc    900

tctctccgtc gtgggaggag ctctgaactt ctccttcatc cagggatggg ccccagggac    960

ccaccagtgg ggctgggaga agcccccctc agcaggaaga cagaggtgcc tgggtggccg   1020

aggcctggaa ggtctgcacc atggtgcaca gaggccccgg agctgggtga ggccagaaag   1080

ctgctctggg gtcagcgggg aatgtgcctg ctgaatctgt acctgagcta cgtcttcaca   1140

aatggcctca gacctagagt gcagggagat cccctggctt ttctgaagtg gtggcaggtg   1200

gtctcctggg tagcaggatc tgggctgctt acttccctta cccagtgagg gcccgcgggg   1260

agctcttaag ttgggcatca tggggctgcg tgatgtggct gctgtgccca catcagaggg   1320

tttttgtttc ttttccaaag tcaagctgca ctaatctaga ccagggatcc ccacccctgg   1380

gctgcagacc ggtccccatg ggtggcctgt taggaactgg accgcacagc aggaggtgag   1440

cagtgggtga gtgcgcgtga ccacctgagc tctgccttct gtgagatcag cagcgccact   1500

gcatctcaga ggaatgccaa ccctactgtg aactgtgcat gcgagggatc tgggttgcat   1560

gctctttatg agatcaaact aatgcctgat gatctcaggt ggaacagttt aatcctgaaa   1620

ccatcccccc atctgtggaa aaactgcctt ccactaaacc agtccctggt gccaaaaaca   1680

ctgggaaccg ctaatctaga cagttctctg ctaaggaagc acgtggttga gaagcatcag   1740

aatcgttccc acggaccatg ctccggagtc tcagcaggct cctgcagtgt gtttatccgt   1800

gcatcatgaa ggaccctcat acggctgacg tgccttggct gatgcgaata acactgcagc   1860

aagcgtggca gtgcagatag ctcttggaaa tacccatttc cttcagacgc atactcagag   1920

gtaggattgc tggattgttt ggtcattttg atttttaaaa ttaaaaagaa ttttaattct   1980

catattgttt tgagtaaaat taaattataa cttgtaaggc aaaaaaaaaa aaaaaaaaaa   2040

aaaa                                                                2044


<210>  1222
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  1222

Met Ala Leu Pro Gln Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Gln Glu Glu Trp Lys Cys Leu Asp Pro Ala Gln Arg Thr Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu Glu 
        35                  40                  45              


Leu Ser Gly Glu Cys Pro Leu Ala Ala Pro Ala Ser 
    50                  55                  60  


<210>  1223
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1223
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgcccc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag gtgcctccac ccagaattct aacactgtgg agccagagaa   2400

gcaggtggac aacaccgtga agatggctgg cgtgatcgct ggcctcctca tgttcatcat   2460

cattctcctg ggcgtgatgc tcaccatcaa aaggagaaga aatgcttatt cctactccta   2520

ttacttgtcc caaaggaagc tggccaagaa gcagaaggag acccagagtg gagcccagag   2580

ggagatgggg cctgtggcct ctgccgacaa acccaccacc aagctcagcg ccagccgcaa   2640

tgatgaaggc ttctcttcta gttctcagga cgtcaacgga ttcacagatg gcagccgcgg   2700

ggagctttcc cagcccaccc tcacgatcca gactcatccc taccgcacct gtgaccctgt   2760

ggagatgagc tacccccggg accagttcca acccgccatc cgggtggctg acttgctgca   2820

gcacatcacg cagatgaaga gaggccaggg ctacgggttc aaggaggaat acgaggcctt   2880

accagagggg cagacagctt cgtgggacac agccaaggag gatgaaaacc gcaataagaa   2940

tcgatatggg aacatcatat cctacgacca ttcccgggtg aggctgctgg tgctggatgg   3000

agacccgcac tctgactaca tcaatgccaa ctacattgac ggataccatc gacctcggca   3060

ctacattgcg actcaaggtc cgatgcagga gactgtaaag gacttttgga gaatgatctg   3120

gcaggagaac tccgccagca tcgtcatggt cacaaacctg gtggaagtgg gcagggtgaa   3180

atgtgtgcga tactggccag atgacacgga ggtctacgga gacattaaag tcaccctgat   3240

tgaaacagag cccctggcag aatacgtcat acgcaccttc acagtccaga agaaaggcta   3300

ccatgagatc cgggagctcc gcctcttcca cttcaccagc tggcctgacc acggcgttcc   3360

ctgctatgcc actggccttc tgggcttcgt ccgccaggtc aagttcctca accccccgga   3420

agctgggccc atagtggtcc actgcagtgc tggggctggg cggactggct gcttcattgc   3480

cattgacacc atgcttgaca tggccgagaa tgaaggggtg gtggacatct tcaactgcgt   3540

gcgtgagctc cgggcccaaa gggtcaacct ggtacagaca gaggagcaat atgtgtttgt   3600

gcacgatgcc atcctggaag cgtgcctctg tggcaacact gccatccctg tgtgtgagtt   3660

ccgttctctc tactacaata tcagcaggct ggacccccag acaaactcca gccaaatcaa   3720

agatgaattt cagaccctca acattgtgac accccgtgtg cggcccgagg actgcagcat   3780

tgggctcctg ccccggaacc atgataagaa tcgaagtatg gacgtgctgc ctctggaccg   3840

ctgcctgccc ttccttatct cagtggacgg agaatccagc aattacatca acgcagcact   3900

gatggatagc cacaagcagc ctgccgcctt cgtggtcacc cagcaccctc tacccaacac   3960

cgtggcagac ttctggaggc tggtgttcga ttacaactgc tcctctgtgg tgatgctgaa   4020

tgagatggac actgcccagt tctgtatgca gtactggcct gagaagacct ccgggtgcta   4080

tgggcccatc caggtggagt tcgtctccgc agacatcgac gaggacatca tccacagaat   4140

attccgcatc tgtaacatgg cccggccaca ggatggttat cgtatagtcc agcacctcca   4200

gtacattggc tggcctgcct accgggacac gcccccctcc aagcgctctc tgctcaaagt   4260

ggtccgacga ctggagaagt ggcaggagca gtatgacggg agggagggac gtactgtggt   4320

ccactgccta aatgggggag gccgtagtgg aaccttctgt gccatctgca gtgtgtgtga   4380

gatgatccag cagcaaaaca tcattgacgt gttccacatc gtgaaaacac tgcgtaacaa   4440

caaatccaac atggtggaga ccctggaaca gtataaattt gtatacgagg tggcactgga   4500

atatttaagc tccttttagc tcaatgggat ggggaacctg ccggagtcca gaggctgctg   4560

tgaccaagcc cccttttgtg tgaatggcag taactgggct caggagctct gaggtggcac   4620

cctgcctgac tccaaggaga agactggtgg ccctgtgttc cacggggggc tctgcacctt   4680

ctgaggggtc tcctgttgcc gtgggagatg ctgctccaaa aggcccaggc ttccttttca   4740

acctaaccag ccacagccaa gggcccaagc agaagtacac ccacaagcaa ggccttggat   4800

ttctggctcc cagaccacct gcttttgttc tgagtttgtg gatctcttgg caagccaact   4860

gtgcaggtgc tggggagtgg gaggctcccc tgccctcctt ctccttagga gtggaggaga   4920

tgtgtgttct gctcctctac gtcatggaaa agattgaggc tcttgggggt cactgctctg   4980

ctgccccctg caacctcctt caggggcctc tggcaccaga catttgcagt ctggaccagt   5040

gtgaccttac gatgttccct aggccacaag agaggccccc catcctcaca cctaacctgc   5100

atggggcttc gcccacaacc attctgtacc ccttccccag cctgggcctt gaccgtccag   5160

cattcactgg ccggccagct gtgtccacag cagtttttga taaaggtgtt ctttgctttt   5220

ttgtgtggtc agtgggaggg ggtggaactg cagggaactt ctctgctcct ccttgtcttt   5280

gtaaaaaggg accacctccc tggggcaggg cttgggctga cctgtaggat gtaacccctg   5340

tgtttctttg gtggtagctt tctttggaag agacaaacaa gataagattt gattattttc   5400

caaagtgtat gtgaaaagaa actttctttt ggagggtgta aaatcttagt ctcttatgtc   5460

aaaaagaagg gggcggggga gtttgagtat gtacctctaa gacaaatctc tcgggccttt   5520

tattttttcc tggcaatgtc cttaaaagct cccaccctgg gacagcatgc cactgagcaa   5580

ggagagatgg gtgagcctga agatggtccc tttggtttct ggggcaaata gagcaccagc   5640

tttgtgcata atttggatgt ccaaatttga actccttcct aaagaaaccc agcagccacc   5700

ttgaaaaagg ccattgtgga gcccattata ctttgattta aaataggcca agagaatcag   5760

gcctggagat ctagggtctt gtccaaagtg tgagtgagtc aatgagaggg aaccaacatt   5820

tgctaagtct ctactgtatg ccagggatca tgcttggcac tttccatagg acatttcaca   5880

cagtccttag aacccccagg agagagctac tgacttgtta tcatctccat ttgatcatct   5940

cctccaatga ggaaacccac gcaccttcct tagtaatgaa atcctgggtt ccaaaggggc   6000

aggtaatggc aatgagactt ctccgtgctg ttttcttcat cttctctaag ccaagcaatt   6060

attttatgga gggaaaataa ggccagaaac ttctgagcag ataactccac aaatggaaat   6120

ttagtacttt cttcctgatg ccagttcttc tgggaagcgc agaatttcag atatatttta   6180

gtaacacatt cccagctccc caggaaagcc agtctcatct aatttcttag tcagtaaaaa   6240

caattccctg ttccttcagg ctatgaatgg accagccagg gaaactctcg accttgatct   6300

ctagccagtg cttaggccca atatctgaca gcctcaggtg ggctgggacc taggaagctc   6360

catcttgaag gctggtctag ccccagacag ggcatgaggg gcagagaatt caagaaggta   6420

cagctttggc cctcaagagc ccactgtatg ctggggaaat ggaaccatgg tgcagtagtg   6480

tggagtggat gagtgttcca tgagcctagg agcaagaaag tctcttcggc ctcgggcttc   6540

ctggagaagg ggacgtccat tcctgctggg tcttaacaag cataaaaagg aaaaaaagga   6600

aactcaggca aagggatcca tatgtgcaat ggcaaagaaa tgtgaaaagg cattgggaga   6660

agcagtctgg gggaggccag cccagtgcgg gcacagcaca acacggggag cagcaagaga   6720

tgagccaggg tccaggagac agatgcccat cgcgagtaca gactttgtcc tattggcaac   6780

aaggagtcca tggagcttta gagagatgca ctcagcttcg tgttggccaa gactccttct   6840

gggccaatgg ggctgcctct tttcctttca tcagacactg tgaaaacatt cccttaagcg   6900

tgcacttttt aatatcacat ctatttgtct gtctgctcat tgttttgttg ctggaactaa   6960

atatgcaatg gatcatgaga ctcagattct atgagaaacc cagggtctct gctttaccac   7020

ggagcagggt caccaaccca gatctccagg cccatgagga tggaacatga aaggagccga   7080

caaaagttgc ttccattggc atgggctctg gagctgtcca gaagtccagg gacaccagac   7140

ttgatcaagg aagggctgtc actttagagg ttcaaaagga agtgcctcaa agcaaaggca   7200

agcaaaggaa ccccacgatg aacttgctct tttcctttga tgagcctctc cccaggtgta   7260

tttcagcaga ccccggggac ccacccccac tgggcctgct ggcctccctc ggctccagcc   7320

caatgcccca gctggccttc cccagcctgc aaggagcctg tagcatggca aatctgcctg   7380

ctgtatgcta ttttcttaga tcttggtaca tccagacagg atgagggtgg agggagagct   7440

atttaacaca aatcctaaga tttttttctg ctcaggaagg ggtgaaatag ctggcagata   7500

caaaagacag tggcttttat cattttaaat ggtaggaatt taaggtgtga cttcagggag   7560

aaacaaactt gcaaaaaaaa aaaatctcag gccatgttgg ggtaacccag caagggccag   7620

tgatgatttc ccccagctca tccccttatt ttcccacaac ccaaccattc tctaaagcag   7680

gacagtgaat aggtcttagg ccagtgcaca caggaagaaa ttgaggctta tggatgggga   7740

tgacttccct aagatcccat gggacaagga tgtggcaagg cttggatgag atggggcacc   7800

agtgcccagg aatttgaaca ttttccttta cccaggaaat ctccggagcc aacaccacca   7860

cccccagggg gtctccccac cccaccccat ttacagggtg agctcagcct gtcatgagca   7920

gaggaaaata ttattaatgc tctctgagtc tttacaacag gagctcttac ctcatagatg   7980

tgggctctgt ttggggaaga tgcaaggaag taatgagaag cccaggaaat ttctccacct   8040

gtgtttatgg cctaaatagc ttcaggatgt atcttagctg cactccaaca ttgcatcctt   8100

tctggggtga agaatctggg ccaaccaggg gtccttgggc ctctagaagg ccacagtagg   8160

cctctctttg tgggaatgga aggggacagt tt                                 8192


<210>  1224
<211>  1444
<212>  PRT
<213>  Homosapiens

<400>  1224

Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu 
                725                 730                 735     


Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala 
            740                 745                 750         


Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile 
        755                 760                 765             


Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Ser Gln Arg 
    770                 775                 780                 


Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu 
785                 790                 795                 800 


Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala 
                805                 810                 815     


Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly 
            820                 825                 830         


Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile 
        835                 840                 845             


Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro 
    850                 855                 860                 


Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His 
865                 870                 875                 880 


Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr 
                885                 890                 895     


Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu 
            900                 905                 910         


Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp 
        915                 920                 925             


His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp 
    930                 935                 940                 


Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr 
945                 950                 955                 960 


Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg 
                965                 970                 975     


Met Ile Trp Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu 
            980                 985                 990         


Val Glu Val Gly Arg Val Lys Cys  Val Arg Tyr Trp Pro  Asp Asp Thr 
        995                 1000                 1005             


Glu Val  Tyr Gly Asp Ile Lys  Val Thr Leu Ile Glu  Thr Glu Pro 
    1010                 1015                 1020             


Leu Ala  Glu Tyr Val Ile Arg  Thr Phe Thr Val Gln  Lys Lys Gly 
    1025                 1030                 1035             


Tyr His  Glu Ile Arg Glu Leu  Arg Leu Phe His Phe  Thr Ser Trp 
    1040                 1045                 1050             


Pro Asp  His Gly Val Pro Cys  Tyr Ala Thr Gly Leu  Leu Gly Phe 
    1055                 1060                 1065             


Val Arg  Gln Val Lys Phe Leu  Asn Pro Pro Glu Ala  Gly Pro Ile 
    1070                 1075                 1080             


Val Val  His Cys Ser Ala Gly  Ala Gly Arg Thr Gly  Cys Phe Ile 
    1085                 1090                 1095             


Ala Ile  Asp Thr Met Leu Asp  Met Ala Glu Asn Glu  Gly Val Val 
    1100                 1105                 1110             


Asp Ile  Phe Asn Cys Val Arg  Glu Leu Arg Ala Gln  Arg Val Asn 
    1115                 1120                 1125             


Leu Val  Gln Thr Glu Glu Gln  Tyr Val Phe Val His  Asp Ala Ile 
    1130                 1135                 1140             


Leu Glu  Ala Cys Leu Cys Gly  Asn Thr Ala Ile Pro  Val Cys Glu 
    1145                 1150                 1155             


Phe Arg  Ser Leu Tyr Tyr Asn  Ile Ser Arg Leu Asp  Pro Gln Thr 
    1160                 1165                 1170             


Asn Ser  Ser Gln Ile Lys Asp  Glu Phe Gln Thr Leu  Asn Ile Val 
    1175                 1180                 1185             


Thr Pro  Arg Val Arg Pro Glu  Asp Cys Ser Ile Gly  Leu Leu Pro 
    1190                 1195                 1200             


Arg Asn  His Asp Lys Asn Arg  Ser Met Asp Val Leu  Pro Leu Asp 
    1205                 1210                 1215             


Arg Cys  Leu Pro Phe Leu Ile  Ser Val Asp Gly Glu  Ser Ser Asn 
    1220                 1225                 1230             


Tyr Ile  Asn Ala Ala Leu Met  Asp Ser His Lys Gln  Pro Ala Ala 
    1235                 1240                 1245             


Phe Val  Val Thr Gln His Pro  Leu Pro Asn Thr Val  Ala Asp Phe 
    1250                 1255                 1260             


Trp Arg  Leu Val Phe Asp Tyr  Asn Cys Ser Ser Val  Val Met Leu 
    1265                 1270                 1275             


Asn Glu  Met Asp Thr Ala Gln  Phe Cys Met Gln Tyr  Trp Pro Glu 
    1280                 1285                 1290             


Lys Thr  Ser Gly Cys Tyr Gly  Pro Ile Gln Val Glu  Phe Val Ser 
    1295                 1300                 1305             


Ala Asp  Ile Asp Glu Asp Ile  Ile His Arg Ile Phe  Arg Ile Cys 
    1310                 1315                 1320             


Asn Met  Ala Arg Pro Gln Asp  Gly Tyr Arg Ile Val  Gln His Leu 
    1325                 1330                 1335             


Gln Tyr  Ile Gly Trp Pro Ala  Tyr Arg Asp Thr Pro  Pro Ser Lys 
    1340                 1345                 1350             


Arg Ser  Leu Leu Lys Val Val  Arg Arg Leu Glu Lys  Trp Gln Glu 
    1355                 1360                 1365             


Gln Tyr  Asp Gly Arg Glu Gly  Arg Thr Val Val His  Cys Leu Asn 
    1370                 1375                 1380             


Gly Gly  Gly Arg Ser Gly Thr  Phe Cys Ala Ile Cys  Ser Val Cys 
    1385                 1390                 1395             


Glu Met  Ile Gln Gln Gln Asn  Ile Ile Asp Val Phe  His Ile Val 
    1400                 1405                 1410             


Lys Thr  Leu Arg Asn Asn Lys  Ser Asn Met Val Glu  Thr Leu Glu 
    1415                 1420                 1425             


Gln Tyr  Lys Phe Val Tyr Glu  Val Ala Leu Glu Tyr  Leu Ser Ser 
    1430                 1435                 1440             


Phe 
    


<210>  1225
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1225
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgcccc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag caccaatggg cagcgcccag gtgaccccgg ggactccact   2400

ctgcctcctc accacaggtg cctccaccca gaattctaac actgtggagc cagagaagca   2460

ggtggacaac accgtgaaga tggctggcgt gatcgctggc ctcctcatgt tcatcatcat   2520

tctcctgggc gtgatgctca ccatcaaaag gagaagaaat gcttattcct actcctatta   2580

cttgtcccaa aggaagctgg ccaagaagca gaaggagacc cagagtggag cccagaggga   2640

gatggggcct gtggcctctg ccgacaaacc caccaccaag ctcagcgcca gccgcaatga   2700

tgaaggcttc tcttctagtt ctcaggacgt caacggattc acagatggca gccgcgggga   2760

gctttcccag cccaccctca cgatccagac tcatccctac cgcacctgtg accctgtgga   2820

gatgagctac ccccgggacc agttccaacc cgccatccgg gtggctgact tgctgcagca   2880

catcacgcag atgaagagag gccagggcta cgggttcaag gaggaatacg aggccttacc   2940

agaggggcag acagcttcgt gggacacagc caaggaggat gaaaaccgca ataagaatcg   3000

atatgggaac atcatatcct acgaccattc ccgggtgagg ctgctggtgc tggatggaga   3060

cccgcactct gactacatca atgccaacta cattgacgga taccatcgac ctcggcacta   3120

cattgcgact caaggtccga tgcaggagac tgtaaaggac ttttggagaa tgatctggca   3180

ggagaactcc gccagcatcg tcatggtcac aaacctggtg gaagtgggca gggtgaaatg   3240

tgtgcgatac tggccagatg acacggaggt ctacggagac attaaagtca ccctgattga   3300

aacagagccc ctggcagaat acgtcatacg caccttcaca gtccagaaga aaggctacca   3360

tgagatccgg gagctccgcc tcttccactt caccagctgg cctgaccacg gcgttccctg   3420

ctatgccact ggccttctgg gcttcgtccg ccaggtcaag ttcctcaacc ccccggaagc   3480

tgggcccata gtggtccact gcagtgctgg ggctgggcgg actggctgct tcattgccat   3540

tgacaccatg cttgacatgg ccgagaatga aggggtggtg gacatcttca actgcgtgcg   3600

tgagctccgg gcccaaaggg tcaacctggt acagacagag gagcaatatg tgtttgtgca   3660

cgatgccatc ctggaagcgt gcctctgtgg caacactgcc atccctgtgt gtgagttccg   3720

ttctctctac tacaatatca gcaggctgga cccccagaca aactccagcc aaatcaaaga   3780

tgaatttcag accctcaaca ttgtgacacc ccgtgtgcgg cccgaggact gcagcattgg   3840

gctcctgccc cggaaccatg ataagaatcg aagtatggac gtgctgcctc tggaccgctg   3900

cctgcccttc cttatctcag tggacggaga atccagcaat tacatcaacg cagcactgat   3960

ggatagccac aagcagcctg ccgccttcgt ggtcacccag caccctctac ccaacaccgt   4020

ggcagacttc tggaggctgg tgttcgatta caactgctcc tctgtggtga tgctgaatga   4080

gatggacact gcccagttct gtatgcagta ctggcctgag aagacctccg ggtgctatgg   4140

gcccatccag gtggagttcg tctccgcaga catcgacgag gacatcatcc acagaatatt   4200

ccgcatctgt aacatggccc ggccacagga tggttatcgt atagtccagc acctccagta   4260

cattggctgg cctgcctacc gggacacgcc cccctccaag cgctctctgc tcaaagtggt   4320

ccgacgactg gagaagtggc aggagcagta tgacgggagg gagggacgta ctgtggtcca   4380

ctgcctaaat gggggaggcc gtagtggaac cttctgtgcc atctgcagtg tgtgtgagat   4440

gatccagcag caaaacatca ttgacgtgtt ccacatcgtg aaaacactgc gtaacaacaa   4500

atccaacatg gtggagaccc tggaacagta taaatttgta tacgaggtgg cactggaata   4560

tttaagctcc ttttagctca atgggatggg gaacctgccg gagtccagag gctgctgtga   4620

ccaagccccc ttttgtgtga atggcagtaa ctgggctcag gagctctgag gtggcaccct   4680

gcctgactcc aaggagaaga ctggtggccc tgtgttccac ggggggctct gcaccttctg   4740

aggggtctcc tgttgccgtg ggagatgctg ctccaaaagg cccaggcttc cttttcaacc   4800

taaccagcca cagccaaggg cccaagcaga agtacaccca caagcaaggc cttggatttc   4860

tggctcccag accacctgct tttgttctga gtttgtggat ctcttggcaa gccaactgtg   4920

caggtgctgg ggagtgggag gctcccctgc cctccttctc cttaggagtg gaggagatgt   4980

gtgttctgct cctctacgtc atggaaaaga ttgaggctct tgggggtcac tgctctgctg   5040

ccccctgcaa cctccttcag gggcctctgg caccagacat ttgcagtctg gaccagtgtg   5100

accttacgat gttccctagg ccacaagaga ggccccccat cctcacacct aacctgcatg   5160

gggcttcgcc cacaaccatt ctgtacccct tccccagcct gggccttgac cgtccagcat   5220

tcactggccg gccagctgtg tccacagcag tttttgataa aggtgttctt tgcttttttg   5280

tgtggtcagt gggagggggt ggaactgcag ggaacttctc tgctcctcct tgtctttgta   5340

aaaagggacc acctccctgg ggcagggctt gggctgacct gtaggatgta acccctgtgt   5400

ttctttggtg gtagctttct ttggaagaga caaacaagat aagatttgat tattttccaa   5460

agtgtatgtg aaaagaaact ttcttttgga gggtgtaaaa tcttagtctc ttatgtcaaa   5520

aagaaggggg cgggggagtt tgagtatgta cctctaagac aaatctctcg ggccttttat   5580

tttttcctgg caatgtcctt aaaagctccc accctgggac agcatgccac tgagcaagga   5640

gagatgggtg agcctgaaga tggtcccttt ggtttctggg gcaaatagag caccagcttt   5700

gtgcataatt tggatgtcca aatttgaact ccttcctaaa gaaacccagc agccaccttg   5760

aaaaaggcca ttgtggagcc cattatactt tgatttaaaa taggccaaga gaatcaggcc   5820

tggagatcta gggtcttgtc caaagtgtga gtgagtcaat gagagggaac caacatttgc   5880

taagtctcta ctgtatgcca gggatcatgc ttggcacttt ccataggaca tttcacacag   5940

tccttagaac ccccaggaga gagctactga cttgttatca tctccatttg atcatctcct   6000

ccaatgagga aacccacgca ccttccttag taatgaaatc ctgggttcca aaggggcagg   6060

taatggcaat gagacttctc cgtgctgttt tcttcatctt ctctaagcca agcaattatt   6120

ttatggaggg aaaataaggc cagaaacttc tgagcagata actccacaaa tggaaattta   6180

gtactttctt cctgatgcca gttcttctgg gaagcgcaga atttcagata tattttagta   6240

acacattccc agctccccag gaaagccagt ctcatctaat ttcttagtca gtaaaaacaa   6300

ttccctgttc cttcaggcta tgaatggacc agccagggaa actctcgacc ttgatctcta   6360

gccagtgctt aggcccaata tctgacagcc tcaggtgggc tgggacctag gaagctccat   6420

cttgaaggct ggtctagccc cagacagggc atgaggggca gagaattcaa gaaggtacag   6480

ctttggccct caagagccca ctgtatgctg gggaaatgga accatggtgc agtagtgtgg   6540

agtggatgag tgttccatga gcctaggagc aagaaagtct cttcggcctc gggcttcctg   6600

gagaagggga cgtccattcc tgctgggtct taacaagcat aaaaaggaaa aaaaggaaac   6660

tcaggcaaag ggatccatat gtgcaatggc aaagaaatgt gaaaaggcat tgggagaagc   6720

agtctggggg aggccagccc agtgcgggca cagcacaaca cggggagcag caagagatga   6780

gccagggtcc aggagacaga tgcccatcgc gagtacagac tttgtcctat tggcaacaag   6840

gagtccatgg agctttagag agatgcactc agcttcgtgt tggccaagac tccttctggg   6900

ccaatggggc tgcctctttt cctttcatca gacactgtga aaacattccc ttaagcgtgc   6960

actttttaat atcacatcta tttgtctgtc tgctcattgt tttgttgctg gaactaaata   7020

tgcaatggat catgagactc agattctatg agaaacccag ggtctctgct ttaccacgga   7080

gcagggtcac caacccagat ctccaggccc atgaggatgg aacatgaaag gagccgacaa   7140

aagttgcttc cattggcatg ggctctggag ctgtccagaa gtccagggac accagacttg   7200

atcaaggaag ggctgtcact ttagaggttc aaaaggaagt gcctcaaagc aaaggcaagc   7260

aaaggaaccc cacgatgaac ttgctctttt cctttgatga gcctctcccc aggtgtattt   7320

cagcagaccc cggggaccca cccccactgg gcctgctggc ctccctcggc tccagcccaa   7380

tgccccagct ggccttcccc agcctgcaag gagcctgtag catggcaaat ctgcctgctg   7440

tatgctattt tcttagatct tggtacatcc agacaggatg agggtggagg gagagctatt   7500

taacacaaat cctaagattt ttttctgctc aggaaggggt gaaatagctg gcagatacaa   7560

aagacagtgg cttttatcat tttaaatggt aggaatttaa ggtgtgactt cagggagaaa   7620

caaacttgca aaaaaaaaaa atctcaggcc atgttggggt aacccagcaa gggccagtga   7680

tgatttcccc cagctcatcc ccttattttc ccacaaccca accattctct aaagcaggac   7740

agtgaatagg tcttaggcca gtgcacacag gaagaaattg aggcttatgg atggggatga   7800

cttccctaag atcccatggg acaaggatgt ggcaaggctt ggatgagatg gggcaccagt   7860

gcccaggaat ttgaacattt tcctttaccc aggaaatctc cggagccaac accaccaccc   7920

ccagggggtc tccccacccc accccattta cagggtgagc tcagcctgtc atgagcagag   7980

gaaaatatta ttaatgctct ctgagtcttt acaacaggag ctcttacctc atagatgtgg   8040

gctctgtttg gggaagatgc aaggaagtaa tgagaagccc aggaaatttc tccacctgtg   8100

tttatggcct aaatagcttc aggatgtatc ttagctgcac tccaacattg catcctttct   8160

ggggtgaaga atctgggcca accaggggtc ct                                 8192


<210>  1226
<211>  1463
<212>  PRT
<213>  Homosapiens

<400>  1226

Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Ala Pro Met Gly Ser Ala Gln Val Thr Pro Gly 
                725                 730                 735     


Thr Pro Leu Cys Leu Leu Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn 
            740                 745                 750         


Thr Val Glu Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly 
        755                 760                 765             


Val Ile Ala Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met 
    770                 775                 780                 


Leu Thr Ile Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu 
785                 790                 795                 800 


Ser Gln Arg Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala 
                805                 810                 815     


Gln Arg Glu Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys 
            820                 825                 830         


Leu Ser Ala Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp 
        835                 840                 845             


Val Asn Gly Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr 
    850                 855                 860                 


Leu Thr Ile Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met 
865                 870                 875                 880 


Ser Tyr Pro Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu 
                885                 890                 895     


Leu Gln His Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys 
            900                 905                 910         


Glu Glu Tyr Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr 
        915                 920                 925             


Ala Lys Glu Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile 
    930                 935                 940                 


Ser Tyr Asp His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro 
945                 950                 955                 960 


His Ser Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro 
                965                 970                 975     


Arg His Tyr Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp 
            980                 985                 990         


Phe Trp Arg Met Ile Trp Gln Glu  Asn Ser Ala Ser Ile  Val Met Val 
        995                 1000                 1005             


Thr Asn  Leu Val Glu Val Gly  Arg Val Lys Cys Val  Arg Tyr Trp 
    1010                 1015                 1020             


Pro Asp  Asp Thr Glu Val Tyr  Gly Asp Ile Lys Val  Thr Leu Ile 
    1025                 1030                 1035             


Glu Thr  Glu Pro Leu Ala Glu  Tyr Val Ile Arg Thr  Phe Thr Val 
    1040                 1045                 1050             


Gln Lys  Lys Gly Tyr His Glu  Ile Arg Glu Leu Arg  Leu Phe His 
    1055                 1060                 1065             


Phe Thr  Ser Trp Pro Asp His  Gly Val Pro Cys Tyr  Ala Thr Gly 
    1070                 1075                 1080             


Leu Leu  Gly Phe Val Arg Gln  Val Lys Phe Leu Asn  Pro Pro Glu 
    1085                 1090                 1095             


Ala Gly  Pro Ile Val Val His  Cys Ser Ala Gly Ala  Gly Arg Thr 
    1100                 1105                 1110             


Gly Cys  Phe Ile Ala Ile Asp  Thr Met Leu Asp Met  Ala Glu Asn 
    1115                 1120                 1125             


Glu Gly  Val Val Asp Ile Phe  Asn Cys Val Arg Glu  Leu Arg Ala 
    1130                 1135                 1140             


Gln Arg  Val Asn Leu Val Gln  Thr Glu Glu Gln Tyr  Val Phe Val 
    1145                 1150                 1155             


His Asp  Ala Ile Leu Glu Ala  Cys Leu Cys Gly Asn  Thr Ala Ile 
    1160                 1165                 1170             


Pro Val  Cys Glu Phe Arg Ser  Leu Tyr Tyr Asn Ile  Ser Arg Leu 
    1175                 1180                 1185             


Asp Pro  Gln Thr Asn Ser Ser  Gln Ile Lys Asp Glu  Phe Gln Thr 
    1190                 1195                 1200             


Leu Asn  Ile Val Thr Pro Arg  Val Arg Pro Glu Asp  Cys Ser Ile 
    1205                 1210                 1215             


Gly Leu  Leu Pro Arg Asn His  Asp Lys Asn Arg Ser  Met Asp Val 
    1220                 1225                 1230             


Leu Pro  Leu Asp Arg Cys Leu  Pro Phe Leu Ile Ser  Val Asp Gly 
    1235                 1240                 1245             


Glu Ser  Ser Asn Tyr Ile Asn  Ala Ala Leu Met Asp  Ser His Lys 
    1250                 1255                 1260             


Gln Pro  Ala Ala Phe Val Val  Thr Gln His Pro Leu  Pro Asn Thr 
    1265                 1270                 1275             


Val Ala  Asp Phe Trp Arg Leu  Val Phe Asp Tyr Asn  Cys Ser Ser 
    1280                 1285                 1290             


Val Val  Met Leu Asn Glu Met  Asp Thr Ala Gln Phe  Cys Met Gln 
    1295                 1300                 1305             


Tyr Trp  Pro Glu Lys Thr Ser  Gly Cys Tyr Gly Pro  Ile Gln Val 
    1310                 1315                 1320             


Glu Phe  Val Ser Ala Asp Ile  Asp Glu Asp Ile Ile  His Arg Ile 
    1325                 1330                 1335             


Phe Arg  Ile Cys Asn Met Ala  Arg Pro Gln Asp Gly  Tyr Arg Ile 
    1340                 1345                 1350             


Val Gln  His Leu Gln Tyr Ile  Gly Trp Pro Ala Tyr  Arg Asp Thr 
    1355                 1360                 1365             


Pro Pro  Ser Lys Arg Ser Leu  Leu Lys Val Val Arg  Arg Leu Glu 
    1370                 1375                 1380             


Lys Trp  Gln Glu Gln Tyr Asp  Gly Arg Glu Gly Arg  Thr Val Val 
    1385                 1390                 1395             


His Cys  Leu Asn Gly Gly Gly  Arg Ser Gly Thr Phe  Cys Ala Ile 
    1400                 1405                 1410             


Cys Ser  Val Cys Glu Met Ile  Gln Gln Gln Asn Ile  Ile Asp Val 
    1415                 1420                 1425             


Phe His  Ile Val Lys Thr Leu  Arg Asn Asn Lys Ser  Asn Met Val 
    1430                 1435                 1440             


Glu Thr  Leu Glu Gln Tyr Lys  Phe Val Tyr Glu Val  Ala Leu Glu 
    1445                 1450                 1455             


Tyr Leu  Ser Ser Phe 
    1460             


<210>  1227
<211>  5611
<212>  DNA
<213>  Homosapiens

<400>  1227
gcgcgaccgt cccgggggtg gggccgggcg cagcggcgag aggaggcgaa ggtggctgcg     60

gtagcagcag cgcggcagcc tcggacccag cccggagcgc agggcggccg ctgcaggtcc    120

ccgctcccct ccccgtgcgt ccgcccatgg ccgccgccgg gcagctgtgc ttgctctacc    180

tgtcggcggg gctcctgtcc cggctcggcg cagccttcaa cttggacact cgggaggaca    240

acgtgatccg gaaatatgga gaccccggga gcctcttcgg cttctcgctg gccatgcact    300

ggcaactgca gcccgaggac aagcggctgt tgctcgtggg ggccccgcgc ggagaagcgc    360

ttccactgca gagagccaac agaacgggag ggctgtacag ctgcgacatc accgcccggg    420

ggccatgcac gcggatcgag tttgataacg atgctgaccc cacgtcagaa agcaaggaag    480

atcagtggat gggggtcacc gtccagagcc aaggtccagg gggcaaggtc gtgacatgtg    540

ctcaccgata tgaaaaaagg cagcatgtta atacgaagca ggaatcccga gacatctttg    600

ggcggtgtta tgtcctgagt cagaatctca ggattgaaga cgatatggat gggggagatt    660

ggagcttttg tgatgggcga ttgagaggcc atgagaaatt tggctcttgc cagcaaggtg    720

tagcagctac ttttactaaa gactttcatt acattgtatt tggagccccg ggtacttata    780

actggaaagg gattgttcgt gtagagcaaa agaataacac tttttttgac atgaacatct    840

ttgaagatgg gccttatgaa gttggtggag agactgagca tgatgaaagt ctcgttcctg    900

ttcctgctaa cagttactta ggtttttctt tggactcagg gaaaggtatt gtttctaaag    960

atgagatcac ttttgtatct ggtgctccca gagccaatca cagtggagcc gtggttttgc   1020

tgaagagaga catgaagtct gcacatctcc tccctgagca catattcgat ggagaaggtc   1080

tggcctcttc atttggctat gatgtggcgg tggtggacct caacaaggat gggtggcaag   1140

atatagttat tggagcccca cagtattttg atagagatgg agaagttgga ggtgcagtgt   1200

atgtctacat gaaccagcaa ggcagatgga ataatgtgaa gccaattcgt cttaatggaa   1260

ccaaagattc tatgtttggc attgcagtaa aaaatattgg agatattaat caagatggct   1320

acccagatat tgcagttgga gctccgtatg atgacttggg aaaggttttt atctatcatg   1380

gatctgcaaa tggaataaat accaaaccaa cacaggttct caagggtata tcaccttatt   1440

ttggatattc aattgctgga aacatggacc ttgatcgaaa ttcctaccct gatgttgctg   1500

ttggttccct ctcagattca gtaactattt tcagatcccg gcctgtgatt aatattcaga   1560

aaaccatcac agtaactcct aacagaattg acctccgcca gaaaacagcg tgtggggcgc   1620

ctagtgggat atgcctccag gttaaatcct gttttgaata tactgctaac cccgctggtt   1680

ataatccttc aatatcaatt gtgggcacac ttgaagctga aaaagaaaga agaaaatctg   1740

ggctatcctc aagagttcag tttcgaaacc aaggttctga gcccaaatat actcaagaac   1800

taactctgaa gaggcagaaa cagaaagtgt gcatggagga aaccctgtgg ctacaggata   1860

atatcagaga taaactgcgt cccattccca taactgcctc agtggagatc caagagccaa   1920

gctctcgtag gcgagtgaat tcacttccag aagttcttcc aattctgaat tcagatgaac   1980

ccaagacagc tcatattgat gttcacttct taaaagaggg atgtggagac gacaatgtat   2040

gtaacagcaa ccttaaacta gaatataaat tttgcacccg agaaggaaat caagacaaat   2100

tttcttattt accaattcaa aaaggtgtac cagaactagt tctaaaagat cagaaggata   2160

ttgctttaga aataacagtg acaaacagcc cttccaaccc aaggaatccc acaaaagatg   2220

gcgatgacgc ccatgaggct aaactgattg caacgtttcc agacacttta acctattctg   2280

catatagaga actgagggct ttccctgaga aacagttgag ttgtgttgcc aaccagaatg   2340

gctcgcaagc tgactgtgag ctcggaaatc cttttaaaag aaattcaaat gtcacttttt   2400

atttggtttt aagtacaact gaagtcacct ttgacacccc atatctggat attaatctga   2460

agttagaaac aacaagcaat caagataatt tggctccaat tacagctaaa gcaaaagtgg   2520

ttattgaact gcttttatcg gtctcgggag ttgctaaacc ttcccaggtg tattttggag   2580

gtacagttgt tggcgagcaa gctatgaaat ctgaagatga agtgggaagt ttaatagagt   2640

atgaattcag ggtaataaac ttaggtaaac ctcttacaaa cctcggcaca gcaaccttga   2700

acattcagtg gccaaaagaa attagcaatg ggaaatggtt gctttatttg gtgaaagtag   2760

aatccaaagg attggaaaag gtaacttgtg agccacaaaa ggagataaac tccctgaacc   2820

taacggagtc tcacaactca agaaagaaac gggaaattac tgaaaaacag atagatgata   2880

acagaaaatt ttctttattt gctgaaagaa aataccagac tcttaactgt agcgtgaacg   2940

tgaactgtgt gaacatcaga tgcccgctgc gggggctgga cagcaaggcg tctcttattt   3000

tgcgctcgag gttatggaac agcacatttc tagaggaata ttccaaactg aactacttgg   3060

acattctcat gcgagccttc attgatgtga ctgctgctgc cgaaaatatc aggctgccaa   3120

atgcaggcac tcaggttcga gtgactgtgt ttccctcaaa gactgtagct cagtattcgg   3180

gagtaccttg gtggatcatc ctagtggcta ttctcgctgg gatcttgatg cttgctttat   3240

tagtgtttat actatggaag tgtggtttct tcaagagaaa taagaaagat cattatgatg   3300

ccacatatca caaggctgag atccatgctc agccatctga taaagagagg cttacttctg   3360

atgcatagta ttgatctact tctgtaattg tgtggattct ttaaacgctc taggtacgat   3420

gacagtgttc cccgatacca tgctgtaagg atccggaaag aagagcgaga gatcaaagat   3480

gaaaagtata ttgataacct tgaaaaaaaa cagtggatca caaagtggaa cagaaatgaa   3540

agctactcat agcgggggcc taaaaaaaaa aaagcttcac agtacccaaa ctgctttttc   3600

caactcagaa attcaatttg gatttaaaag cctgctcaat ccctgaggac tgatttcaga   3660

gtgactacac acagtacgaa cctacagttt taactgtgga tattgttacg tagcctaagg   3720

ctcctgtttt gcacagccaa atttaaaact gttggaatgg atttttcttt aactgccgta   3780

atttaacttt ctgggttgcc tttgtttttg gcgtggctga cttacatcat gtgttgggga   3840

agggcctgcc cagttgcact caggtgacat cctccagata gtgtagctga ggaggcacct   3900

acactcacct gcactaacag agtggccgtc ctaacctcgg gcctgctgcg cagacgtcca   3960

tcacgttagc tgtcccacat cacaagacta tgccattggg gtagttgtgt ttcaacggaa   4020

agtgctgtct taaactaaat gtgcaataga aggtgatgtt gccatcctac cgtcttttcc   4080

tgtttcctag ctgtgtgaat acctgctcac gtcaaatgca tacaagtttc attctccctt   4140

tcactaaaaa cacacaggtg caacagactt gaatgctagt tatacttatt tgtatatggt   4200

atttattttt tcttttcttt acaaaccatt ttgttattga ctaacaggcc aaagagtctc   4260

cagtttaccc ttcaggttgg tttaatcaat cagaattaga attagagcat gggagggtca   4320

tcactatgac ctaaattatt tactgcaaaa agaaaatctt tataaatgta ccagagagag   4380

ttgttttaat aacttatcta taaactataa cctctccttc atgacagcct ccaccccaca   4440

acccaaaagg tttaagaaat agaattataa ctgtaaagat gtttatttca ggcattggat   4500

attttttact ttagaagcct gcataatgtt tctggattta catactgtaa cattcaggaa   4560

ttcttggaga agatgggttt attcactgaa ctctagtgcg gtttactcac tgctgcaaat   4620

actgtatatt caggacttga aagaaatggt gaatgcctat ggaactagtg gatccaaact   4680

gatccagtat aagactactg aatctgctac caaaacagtt aatcagtgag tcgagtgttc   4740

tattttttgt tttgtttcct cccctatctg tattcccaaa aattactttg gggctaattt   4800

aacaagaact ttaaattgtg ttttaattgt aaaaatggca gggggtggaa ttattactct   4860

atacattcaa cagagactga atagatatga aagctgattt tttttaatta ccatgcttca   4920

caatgttaag ttatatgggg agcaacagca aacaggtgct aatttgtttt ggatatagta   4980

taagcagtgt ctgtgttttg aaagaataga acacagtttg tagtgccact gttgttttgg   5040

ggggggcttt ttttcttttt ccggaaaatc cttaaacctt aagatactaa ggacgttgtt   5100

ttggttgtac ttggaattct tagtcacaaa atatattttg tttacaaaaa tttctgtaaa   5160

acaggttata acagtgttta aagtctcagt ttcttgcttg gggaacttgt gtccctaatg   5220

tgttagattg ctagattgct aaggagctga tacttgacag ttttttagac ctgtgttact   5280

aaaaaaaaga tgaatgtcgg aaaagggtgt tgggagggtg gtcaacaaag aaacaaagat   5340

gttatggtgt ttagacttat ggttgttaaa aatgtcatct caagtcaagt cactggtctg   5400

tttgcatttg atacattttt gtactaacta gcattgtaaa attatttcat gattagaaat   5460

tacctgtgga tatttgtata aaagtgtgaa ataaattttt tataaaagtg ttcattgttt   5520

cgtaacacag cattgtatat gtgaagcaaa ctctaaaatt ataaatgaca acctgaatta   5580

tctatttcat caaaaaaaaa aaaaaaaaaa a                                  5611


<210>  1228
<211>  1073
<212>  PRT
<213>  Homosapiens

<400>  1228

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Asn  Lys Lys Asp His Tyr  Asp Ala Thr 
    1040                 1045                 1050             


Tyr His  Lys Ala Glu Ile His  Ala Gln Pro Ser Asp  Lys Glu Arg 
    1055                 1060                 1065             


Leu Thr  Ser Asp Ala 
    1070             


<210>  1229
<211>  4576
<212>  DNA
<213>  Homosapiens

<400>  1229
gatccccgcc cctgctgccc gccacgtccc tcacgtacca ctcggcagag gcgcggggaa     60

acctggcgta ctggctgtgg cttctctagc gggactcggc atgaggctgg cgcggctgct    120

tcgcggagcc gccttggccg gcccgggccc ggggctgcgc gccgccggct tcagccgcag    180

cttcagctcg gactcgggct ccagcccggc gtccgagcgc ggcgttccgg gccaggtgga    240

cttctacgcg cgcttctcgc cgtccccgct ctccatgaag cagttcctgg acttcggatc    300

agtgaatgct tgtgaaaaga cctcatttat gtttctgcgg caagagttgc ctgtcagact    360

ggcaaatata atgaaagaaa taagtctcct tccagataat cttctcagga caccatccgt    420

tcaattggta caaagctggt atatccagag tcttcaggag cttcttgatt ttaaggacaa    480

aagtgctgag gatgctaaag ctatttatga ctttacagat actgtgatac ggatcagaaa    540

ccgacacaat gatgtcattc ccacaatggc ccagggtgtg attgaataca aggagagctt    600

tggggtggat cctgtcacca gccagaatgt tcagtacttt ttggatcgat tctacatgag    660

tcgcatttca attagaatgt tactcaatca gcactcttta ttgtttggtg gaaaaggcaa    720

aggaagtcca tctcatcgaa aacacattgg aagcataaat ccaaactgca atgtacttga    780

agttattaaa gatggctatg aaaatgctag gcgtctgtgt gatttgtatt atattaactc    840

tcccgaacta gaacttgaag aactaaatgc aaaatcacca ggacagccaa tacaagtggt    900

ttatgtacca tcccatctct atcacatggt gtttgaactt ttcaagaatg caatgagagc    960

cactatggaa caccatgcca acagaggtgt ttacccccct attcaagttc atgtcacgct   1020

gggtaatgag gatttgactg tgaagatgag tgaccgagga ggtggcgttc ctttgaggaa   1080

aattgacaga cttttcaact acatgtattc aactgcacca agacctcgtg ttgagacctc   1140

ccgcgcagtg cctctggctg gttttggtta tggattgccc atatcacgtc tttacgcaca   1200

atacttccaa ggagacctga agctgtattc cctagagggt tacgggacag atgcagttat   1260

ctacattaag gctctgtcaa cagactcaat agaaagactc ccagtgtata acaaagctgc   1320

ctggaagcat tacaacacca accacgaggc tgatgactgg tgcgtcccca gcagagaacc   1380

caaagacatg acgacgttcc gcagtgccta gacacacttg ggacatcgga aaatccaaat   1440

gtggcttttg tattaaattt ggaaggtatg gtgttcagaa ctatattata ccaagtactt   1500

tatttatcgt tttcacaaaa ctatttgagt agaataaatg gaaactgaat tccatttgtg   1560

cccgttaaac ctcctaaagg atgaaattgc acctatttta cacttatatt ttcacagtta   1620

attgaacata tttttaaaca actgtagttt tgggcaactt ttcactttgt ggtagacttc   1680

agaagtgtgg aaatcttcgg gtttctatag gaaactagtt tttttttttt aagaaatact   1740

ttcatttatg tttgctagaa acattttcta aatgatagtg attagctggt tagccatctt   1800

cctgttattt ggaggagttc tgccatcttt tattcggtag tgacagctgt aatatggtct   1860

tcatgtttat cagtgacttg actacaagta aagcagaaaa cagttggcct gtaatcacag   1920

aaccagccac ccttcggcgt ctacatgcat tgtcttagct ctgaggttaa tttaccattt   1980

ttaaatttta ttgtaaagaa gtgtaatgac tagctctctg tggatctatg ccaaaatcat   2040

gggccatctt ttctaagtgt acttctgatt aatgcaaggg gaaattttta tactgaaaac   2100

aaacaaacaa actagcagct actaaaatag agaagaaatt gagggcaaag taatatgtct   2160

ccaaaactga actgattgct tgttgagatt acctagaaag cttttggaaa aaaatagagc   2220

ttttctgcat cctactccag atacactgaa tcggaatccc tagggctaga gcctagaaat   2280

ctcacttttt aaaatgcttc caaggtaagt ctgatgccta ccctaggttg ggaaccactc   2340

tttcaaagta aacagtgatg acacagcatt tgctaaagta acatctgtag gttttggttt   2400

ccacctattt aaagtcagat ttatagactc gaggagacag aaactgaatc ccacacctgg   2460

tgcaattaga agcataatta gaagcagaag aacaaaatgc cacgtaacca aagcatcaga   2520

gccatcattg cacgtgtctt tttttctttt ttcttttttt tttttcaaga cagggtctcg   2580

ctcttttgcc caggatggag tacagtggca tggtcaaggc tcactgcagc ttcaatcttc   2640

tgggctcaag taatccttcc acctcagcct cccatatagc tggaactaca gttgtgcact   2700

accacaccca gctaattttt tgatttcttg tggagatgag gtctcagtat gttcccaggc   2760

tagtgttgaa ctcctgagct caagaaatcc tcctgcctga gtctctgaaa gtgctgggat   2820

tacaggcgtg agccaccaca catggcctat tgcacaagtc ttgacaaaca acatatattt   2880

tctaaaacta tccagatttc attatcaggg aaaagtttgc ttaggtttat tacagcagtc   2940

cttggcattt gtatggtaat ttgtacttta caaatacttt gatatattat aactctattg   3000

gtctttgaaa caaagcgata cagtgtaggt ggtatcattc tctttctcac tcagtgtggc   3060

ccagagttgc tcagaattgg agcagagcct gagacgtatc tgcagatcct gtcatcagct   3120

ggcaagtcca ggagactgtg tcatttagag actgtgttgt tagttatccc tcaacatctt   3180

ctaaggtggc aggaaataat attggaaata acattttaaa gtaaaaattt taaagtttaa   3240

agaagagttt tgccacttaa acaggggagc tttgtctgga aaatacactg agttgaaaca   3300

cttcatcctt ggaaggatta tataagatga acagttgtga taaatgtgta gattagaggg   3360

atgtgaatgg gcagttagtc cagtgccctc atttaagagg ccaagatcct gattcagagg   3420

aggcatcctt tgcccagagc tgcttagcta atctgaccaa atgttgggaa aaatgtctca   3480

cctaacccac tattccttaa ttatggattt tgtgaaaaac aatagaacat gttaatgagt   3540

aatttatatt agttcgatgt attacaattt tttagcttta aattacagtt ttcttataat   3600

gttgaaatgt tttagaatcc tttgaatcta agtatttgtt tcctaaatga aacatttgta   3660

caacatttga tgtttttact tatgaaatat tctcctcccc caagaaaatt taaacttttt   3720

ctctctattt aaaagctaag aaatgtttta aaggaaaaat gaaattatct tcctttagct   3780

tatttttaag gtaaaacagc tttttactct gttattgtgg taatggacag aatattacat   3840

acaaaaatat tctgggagag ctttttccta gttggtttta aatcattgtg ccacctgaaa   3900

ggtttttaga ttttatagga gctaatttgt ccaccagcat taatgtaaca cagtgtagtt   3960

atgaaaatat attgaaggac aggaagtgga cacgaagtga tttttgtaac ctgagcagtt   4020

aatgaatgtg ccaacatttt ctaggaaggg acagcaagaa tattctgctc tgtagttaaa   4080

atactggctg gcttttgatg tcttcatgct taattgtgat cactttcttg cactgtgatg   4140

tttttacgtg aatatgttga agtagaagtc taccatatta ttttataaaa tgttttctgt   4200

atggcaataa actgaaaaca tggatcaacc cttcttttga aaataaactg agtcaattta   4260

gccttttaaa aatatagtca tctcttttaa atagaatcct cttccaccat caaggctcaa   4320

cattttgtaa gcatccaaaa aattggtaat tagggggctt gcactaaatt tcactatctt   4380

cagtagagag gaactgtttg gaacttagat ttccaatgtg tatattctaa tggagaaagc   4440

aagaggtaga gtttgtatgt ttgacttacc ttagattttt attttccata catactgcaa   4500

atgattgact tgttgcataa atgaagatct tctgttgtgt gcttttcaaa cactgtaaat   4560

aaatttgaaa tttgaa                                                   4576


<210>  1230
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  1230

Met Arg Leu Ala Arg Leu Leu Arg Gly Ala Ala Leu Ala Gly Pro Gly 
1               5                   10                  15      


Pro Gly Leu Arg Ala Ala Gly Phe Ser Arg Ser Phe Ser Ser Asp Ser 
            20                  25                  30          


Gly Ser Ser Pro Ala Ser Glu Arg Gly Val Pro Gly Gln Val Asp Phe 
        35                  40                  45              


Tyr Ala Arg Phe Ser Pro Ser Pro Leu Ser Met Lys Gln Phe Leu Asp 
    50                  55                  60                  


Phe Gly Ser Val Asn Ala Cys Glu Lys Thr Ser Phe Met Phe Leu Arg 
65                  70                  75                  80  


Gln Glu Leu Pro Val Arg Leu Ala Asn Ile Met Lys Glu Ile Ser Leu 
                85                  90                  95      


Leu Pro Asp Asn Leu Leu Arg Thr Pro Ser Val Gln Leu Val Gln Ser 
            100                 105                 110         


Trp Tyr Ile Gln Ser Leu Gln Glu Leu Leu Asp Phe Lys Asp Lys Ser 
        115                 120                 125             


Ala Glu Asp Ala Lys Ala Ile Tyr Asp Phe Thr Asp Thr Val Ile Arg 
    130                 135                 140                 


Ile Arg Asn Arg His Asn Asp Val Ile Pro Thr Met Ala Gln Gly Val 
145                 150                 155                 160 


Ile Glu Tyr Lys Glu Ser Phe Gly Val Asp Pro Val Thr Ser Gln Asn 
                165                 170                 175     


Val Gln Tyr Phe Leu Asp Arg Phe Tyr Met Ser Arg Ile Ser Ile Arg 
            180                 185                 190         


Met Leu Leu Asn Gln His Ser Leu Leu Phe Gly Gly Lys Gly Lys Gly 
        195                 200                 205             


Ser Pro Ser His Arg Lys His Ile Gly Ser Ile Asn Pro Asn Cys Asn 
    210                 215                 220                 


Val Leu Glu Val Ile Lys Asp Gly Tyr Glu Asn Ala Arg Arg Leu Cys 
225                 230                 235                 240 


Asp Leu Tyr Tyr Ile Asn Ser Pro Glu Leu Glu Leu Glu Glu Leu Asn 
                245                 250                 255     


Ala Lys Ser Pro Gly Gln Pro Ile Gln Val Val Tyr Val Pro Ser His 
            260                 265                 270         


Leu Tyr His Met Val Phe Glu Leu Phe Lys Asn Ala Met Arg Ala Thr 
        275                 280                 285             


Met Glu His His Ala Asn Arg Gly Val Tyr Pro Pro Ile Gln Val His 
    290                 295                 300                 


Val Thr Leu Gly Asn Glu Asp Leu Thr Val Lys Met Ser Asp Arg Gly 
305                 310                 315                 320 


Gly Gly Val Pro Leu Arg Lys Ile Asp Arg Leu Phe Asn Tyr Met Tyr 
                325                 330                 335     


Ser Thr Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu 
            340                 345                 350         


Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr Ala Gln Tyr 
        355                 360                 365             


Phe Gln Gly Asp Leu Lys Leu Tyr Ser Leu Glu Gly Tyr Gly Thr Asp 
    370                 375                 380                 


Ala Val Ile Tyr Ile Lys Ala Leu Ser Thr Asp Ser Ile Glu Arg Leu 
385                 390                 395                 400 


Pro Val Tyr Asn Lys Ala Ala Trp Lys His Tyr Asn Thr Asn His Glu 
                405                 410                 415     


Ala Asp Asp Trp Cys Val Pro Ser Arg Glu Pro Lys Asp Met Thr Thr 
            420                 425                 430         


Phe Arg Ser Ala 
        435     


<210>  1231
<211>  1157
<212>  DNA
<213>  Homosapiens

<400>  1231
ccatcccggc atactttgcg ccgtgcacag gcaagccctg gtgcgcattg gccccttcgg     60

ccgccgtcgg ccggtagtta ctatggaaac ccagctgcca tcgctatgtc tctgcaaaag    120

acccctccga cccgagtgtt cgtggaactg gttccctggg ctgaccggag ccgggagaac    180

aacctggcct cagggagaga gacgctaccg ggcttacgcc accccctctc ctcaacacaa    240

gcccaaactg ctacccgcga ggtgcaagta agcggcacct cagaagtgtc tgcgggccct    300

gaccgggcgc aggtggtggt gcgagtgagc agcaccaagg aggcggcagc cgaggccaaa    360

aagagcgttt gtcgccgtct agattacatc acgcagagcc tccagcagca gggcgtgcag    420

gcagaaaata taactgtgac aaaggatttt aggagagtgg aaaatgctta tcacatggaa    480

gcagaggtct gcattacatt tactgaattt ggaaaaatgc aaaatatttg taactttctt    540

gttgaaaagc tagatagctc tgttgtcatc agcccacccc agttctatca tactccaggt    600

tctgttgaga atcttcgacg gcaagcctgt cttgttgctg ttgagaatgc gtggcgcaaa    660

gctcaagaag tctgtaacct tgttggccaa accttaggaa aacctttact aatcaaagaa    720

gaagaaacaa aagaatggga aggccaaata gatgatcacc agtcatccag actctcaagt    780

tcattaactg tacaacaaaa aatcaaaagt gcaacaatac atgctgcttc aaaagtattt    840

ataacttttg aggtaaaggg aaaagagaag agaaaaaagc acctttgaaa ttccaaacaa    900

attatattgt acttgtatct ttttacctat ttttatactt tttataatgt ttacgtttgt    960

cctgaatata tatatatata tatatatata tatatatatg gtataggaga taagctattt   1020

ctttccaaaa tctataaatc tttgaatata gtcccacaga atacttatgt tcactttcta   1080

tttttaaaag actactctga aaaacactct tggataataa atgtattatg tgcatactta   1140

tatactgaca gttcata                                                  1157


<210>  1232
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  1232

Met Ser Leu Gln Lys Thr Pro Pro Thr Arg Val Phe Val Glu Leu Val 
1               5                   10                  15      


Pro Trp Ala Asp Arg Ser Arg Glu Asn Asn Leu Ala Ser Gly Arg Glu 
            20                  25                  30          


Thr Leu Pro Gly Leu Arg His Pro Leu Ser Ser Thr Gln Ala Gln Thr 
        35                  40                  45              


Ala Thr Arg Glu Val Gln Val Ser Gly Thr Ser Glu Val Ser Ala Gly 
    50                  55                  60                  


Pro Asp Arg Ala Gln Val Val Val Arg Val Ser Ser Thr Lys Glu Ala 
65                  70                  75                  80  


Ala Ala Glu Ala Lys Lys Ser Val Cys Arg Arg Leu Asp Tyr Ile Thr 
                85                  90                  95      


Gln Ser Leu Gln Gln Gln Gly Val Gln Ala Glu Asn Ile Thr Val Thr 
            100                 105                 110         


Lys Asp Phe Arg Arg Val Glu Asn Ala Tyr His Met Glu Ala Glu Val 
        115                 120                 125             


Cys Ile Thr Phe Thr Glu Phe Gly Lys Met Gln Asn Ile Cys Asn Phe 
    130                 135                 140                 


Leu Val Glu Lys Leu Asp Ser Ser Val Val Ile Ser Pro Pro Gln Phe 
145                 150                 155                 160 


Tyr His Thr Pro Gly Ser Val Glu Asn Leu Arg Arg Gln Ala Cys Leu 
                165                 170                 175     


Val Ala Val Glu Asn Ala Trp Arg Lys Ala Gln Glu Val Cys Asn Leu 
            180                 185                 190         


Val Gly Gln Thr Leu Gly Lys Pro Leu Leu Ile Lys Glu Glu Glu Thr 
        195                 200                 205             


Lys Glu Trp Glu Gly Gln Ile Asp Asp His Gln Ser Ser Arg Leu Ser 
    210                 215                 220                 


Ser Ser Leu Thr Val Gln Gln Lys Ile Lys Ser Ala Thr Ile His Ala 
225                 230                 235                 240 


Ala Ser Lys Val Phe Ile Thr Phe Glu Val Lys Gly Lys Glu Lys Arg 
                245                 250                 255     


Lys Lys His Leu 
            260 


<210>  1233
<211>  4546
<212>  DNA
<213>  Homosapiens

<400>  1233
taccagtttg aatacatggc ccagcacctg gtgtttgcca actgcattcc tttgatccta     60

aagttcttca atcaaaacat catgtcctac atcactgcca agaacagcat ttctgtcctg    120

aatgaaagtg gcgcgccgcc cctgacgtta cccggatcgg agaggttgga attcagatta    180

cggctgcgat tcgggtgtct cggaccccgg tgtgcaccgg accacgggga ggcggctcca    240

aaggcgcggt gaacgttggt gagggagggc agctctgcgc cccaagagat ggctcacaac    300

aagatcccgc cgcggtggct gaactgtccc cggcgcggcc agccggtggc aggaagattc    360

ttacctctga agacaatatt aggaccaaga tatgatagtc aagttgctga agaaaatcgg    420

ttccatccca gcatgctctc aaattaccta aagagcctaa aggttaaaat gggcttgttg    480

gtggacctga caaatacttc aaggttctat gaccgaaatg acatagaaaa agaaggaatc    540

aaatatataa aacttcagtg taaaggacat ggtgagtgcc ctaccactga gaatactgag    600

acctttattc gtctgtgtga gcggtttaat gaaagaaatc cgcctgaact tataggtgtt    660

cattgtactc atggcttcaa tcgcactggt ttcctcatat gtgccttttt ggtggagaaa    720

atggattgga gtatcgaagc agcagttgct acttttgccc aagccagacc accaggaatc    780

tacaagggtg attatttgaa ggaacttttt cgtcggtatg gtgacataga ggaagcacca    840

cccccacctc tattgccaga ttggtgtttt gaggatgatg aagacgaaga tgaggatgag    900

gatggaaaga aggaatcaga acccgggtca agtgcttctt ttggcaaaag gagaaaagaa    960

cggttaaaac tgggcgctat tttcttggaa ggtgttactg ttaaaggtgt aactcaagta   1020

acaacacaac caaagttagg agaggtacag cagaagtgtc atcaattctg tggctgggaa   1080

gggtctggat tccctggagc acagcctgtt tccatggaca agcaaaatat taaactttta   1140

gacctgaagc catacaaagt aagctggaaa gcagatggta ctcggtacat gatgttgatt   1200

gatggcacaa atgaagtttt tatgattgat agagacaatt cagtatttca tgtttcaaat   1260

ctggaatttc catttcgtaa agatcttcgt atgcatttat caaatactct cttggatggc   1320

gagatgatta ttgacagagt aaatggacag gctgttccta gatatttgat atatgacata   1380

attaaattca attcacagcc cgttggagat tgtgatttta atgttcgtct gcagtgtata   1440

gaacgagaaa ttataagtcc tcgacacgaa aaaatgaaga ctgggctcat tgacaaaaca   1500

caggaaccat ttagcgtcag aaataagccg ttttttgaca tctgtacttc aagaaagcta   1560

cttgaaggaa attttgccaa agaagtgagc catgaaatgg atggacttat ttttcagcct   1620

actggaaaat acaaacctgg tcgatgtgat gatattttga aatggaagcc tcccagtctg   1680

aattctgtgg attttcgtct aaaaataacc agaatgggag gagaagggtt acttcctccg   1740

aatgttggcc tcctgtatgt tggaggttat gaaagaccct ttgcacaaat caaggtgaca   1800

aaagagctga aacagtatga caacaaaatt atagaatgca aatttgagaa caacagctgg   1860

gtcttcatga gacagagaac agacaaaagt tttcctaatg cctacaacac tgccatggct   1920

gtgtgtaaca gcatctcaaa ccctgtcacc aaggagatgc tgtttgagtt catcgacaga   1980

tgtactgcag cttctcaagg acagaagcga aaacatcatc tggaccctga cacggagctc   2040

atgccaccac cacctcccaa aagaccacgc cctttaacct aagacctgcc tgtgacttga   2100

gggttaagaa gaaagaggaa tgaggaaaaa acgctgttgc ccatttttgt cgccgagaaa   2160

ttgaaaaacg actgtggctt gatgttgata cacatttgaa atttttttta aaaaaaaaga   2220

attatcgtag ccagcctgta aatacttgat gcattcgttt cctcagtgct gcaatacatc   2280

atggacttaa acatcttatt tatctgataa actcagcctt accttgtgga atctgaagat   2340

tgaaatatcc aaaggtttaa acaagatgga aatcaatgaa aaagaggcct tgtttatata   2400

tgggtagctt cacatttaat ttataaagtt aacaatctgg aaactgtgag cccataaaac   2460

agtatttttt agaagttgtg ttacaactgt agcaaatttt ccttttaaaa aatccaggca   2520

atggcattaa acattcttgc tatcatttac catggatttc ctacatttct gagatccctg   2580

tattcaaaaa caaatgacag ggttgttaag ttgtactata ttaaacaact tggtctggtt   2640

tatatcattt taacaagttt tttggaaatg taaaagaaaa aagtaaagct ccatttttgt   2700

gaattgcatt gtttctaaag gaagtatttt gagtattttc atctgtttgt attgtttcga   2760

ctatgatatc agatatccag tgtgtccatt ctggcagtgg ttttgagtta cttcatggaa   2820

cttggacata caccaccagg tcctttatgt gttgttctcc tgggagactt ctttttttaa   2880

atgccaggct acttctgctt tacctcagtg gtatcagcac attgttaatt acgttaaaac   2940

acacaactca ctgtgatcta tgggagtgat atcaaataca aacgatgttg tgttccttct   3000

ctcgaacaaa acagcaaagg gaatgccagc taacttcttt gattagaagg taatgtcatg   3060

gaatagaatg ctgtcaccag aaaatgctct cccactgcta gataaatgca gaggcaaagt   3120

gtagacatct gtaggaacta aatatcaagg aaatcaagac atttattttc aaagcgagaa   3180

ttctatctac attctattct gcggatgtta tttctgttat acatctgaat tttaaaatgt   3240

ttactgatag ataatggatt taaagggcgg ctaattgatt gtctgccatt gttgataaac   3300

tgttctaatt ggtttgtgaa agaactctga gaattagcta aatggaggct agtgtattta   3360

tttttagagg tacatgtttt aagtaaatgt atttaaaaca aattttcatg gtctgaattg   3420

tatatgtaaa tgcatatctg tgtaagtata tgcaagtgta tattctttct actgatttca   3480

gtcagacacg aaatccaact gaattacccg gtagactgaa tatctgacgg gatttctata   3540

tggacatagc acagatgaac caaaaatgta tttatattca cctgagtttt aatgttttta   3600

aacaaagttt tctcctgcag tgcttttcta tatgaaatag ttgagtcaag cttgggcttt   3660

tttcttcgtt gttcccaagt catgtaatgt atagtgaatt tatccaaaac gccattgtaa   3720

cgttttttac tagagtgttt ttgcacattt gggcgctaaa gggattaaaa caactgatgc   3780

cacaatgact attgaaggag ggaaaattct caaggttcca tagtatcttt acaaaatgga   3840

ttaaaaaaaa atgcctatgc aacttcaaat agtctgatgc ctgcttcccc aggacgagtg   3900

actcttccac ggtgtgctgc tttccctccg agcctgtgga aaggcagagc ccttttgcag   3960

atacgaaagc aagcttttgc caatgatctt taatggagtt aaaatgttta tggtaattgt   4020

aacctttcaa atgagttacg tgaaaagagc atctcacttt taatacaccc agatattttc   4080

ttcaagtctt tgcgcatttt tagcaggact taattttcct aaatttattc tttcctttca   4140

attatagtga catagagtag ttggccttat aagtagatcc catttagccc ctgaacataa   4200

taccatctgc agtattataa aagtcattta gaaggtcagg gggataatct agaggcagga   4260

ttttggacat tgtgaaggaa atgtgctcct tctcagctca cttcaataac tattttctga   4320

gactgaagtt ttttagacaa gaataagaaa actttgcttt cttcagttat cacatgtgaa   4380

agcttttgct ttttgttagg aaaaggtgtg gatgactcta ctgcgtggat ggttacattt   4440

gctttccgtg aaatgctcag aaaatgtcag gacattcctt ttccaattgt gtgtcagtgc   4500

gtattgtaat aaaactactg atggaattcc ggaaaaaaaa aaaaaa                  4546


<210>  1234
<211>  597
<212>  PRT
<213>  Homosapiens

<400>  1234

Met Ala His Asn Lys Ile Pro Pro Arg Trp Leu Asn Cys Pro Arg Arg 
1               5                   10                  15      


Gly Gln Pro Val Ala Gly Arg Phe Leu Pro Leu Lys Thr Ile Leu Gly 
            20                  25                  30          


Pro Arg Tyr Asp Ser Gln Val Ala Glu Glu Asn Arg Phe His Pro Ser 
        35                  40                  45              


Met Leu Ser Asn Tyr Leu Lys Ser Leu Lys Val Lys Met Gly Leu Leu 
    50                  55                  60                  


Val Asp Leu Thr Asn Thr Ser Arg Phe Tyr Asp Arg Asn Asp Ile Glu 
65                  70                  75                  80  


Lys Glu Gly Ile Lys Tyr Ile Lys Leu Gln Cys Lys Gly His Gly Glu 
                85                  90                  95      


Cys Pro Thr Thr Glu Asn Thr Glu Thr Phe Ile Arg Leu Cys Glu Arg 
            100                 105                 110         


Phe Asn Glu Arg Asn Pro Pro Glu Leu Ile Gly Val His Cys Thr His 
        115                 120                 125             


Gly Phe Asn Arg Thr Gly Phe Leu Ile Cys Ala Phe Leu Val Glu Lys 
    130                 135                 140                 


Met Asp Trp Ser Ile Glu Ala Ala Val Ala Thr Phe Ala Gln Ala Arg 
145                 150                 155                 160 


Pro Pro Gly Ile Tyr Lys Gly Asp Tyr Leu Lys Glu Leu Phe Arg Arg 
                165                 170                 175     


Tyr Gly Asp Ile Glu Glu Ala Pro Pro Pro Pro Leu Leu Pro Asp Trp 
            180                 185                 190         


Cys Phe Glu Asp Asp Glu Asp Glu Asp Glu Asp Glu Asp Gly Lys Lys 
        195                 200                 205             


Glu Ser Glu Pro Gly Ser Ser Ala Ser Phe Gly Lys Arg Arg Lys Glu 
    210                 215                 220                 


Arg Leu Lys Leu Gly Ala Ile Phe Leu Glu Gly Val Thr Val Lys Gly 
225                 230                 235                 240 


Val Thr Gln Val Thr Thr Gln Pro Lys Leu Gly Glu Val Gln Gln Lys 
                245                 250                 255     


Cys His Gln Phe Cys Gly Trp Glu Gly Ser Gly Phe Pro Gly Ala Gln 
            260                 265                 270         


Pro Val Ser Met Asp Lys Gln Asn Ile Lys Leu Leu Asp Leu Lys Pro 
        275                 280                 285             


Tyr Lys Val Ser Trp Lys Ala Asp Gly Thr Arg Tyr Met Met Leu Ile 
    290                 295                 300                 


Asp Gly Thr Asn Glu Val Phe Met Ile Asp Arg Asp Asn Ser Val Phe 
305                 310                 315                 320 


His Val Ser Asn Leu Glu Phe Pro Phe Arg Lys Asp Leu Arg Met His 
                325                 330                 335     


Leu Ser Asn Thr Leu Leu Asp Gly Glu Met Ile Ile Asp Arg Val Asn 
            340                 345                 350         


Gly Gln Ala Val Pro Arg Tyr Leu Ile Tyr Asp Ile Ile Lys Phe Asn 
        355                 360                 365             


Ser Gln Pro Val Gly Asp Cys Asp Phe Asn Val Arg Leu Gln Cys Ile 
    370                 375                 380                 


Glu Arg Glu Ile Ile Ser Pro Arg His Glu Lys Met Lys Thr Gly Leu 
385                 390                 395                 400 


Ile Asp Lys Thr Gln Glu Pro Phe Ser Val Arg Asn Lys Pro Phe Phe 
                405                 410                 415     


Asp Ile Cys Thr Ser Arg Lys Leu Leu Glu Gly Asn Phe Ala Lys Glu 
            420                 425                 430         


Val Ser His Glu Met Asp Gly Leu Ile Phe Gln Pro Thr Gly Lys Tyr 
        435                 440                 445             


Lys Pro Gly Arg Cys Asp Asp Ile Leu Lys Trp Lys Pro Pro Ser Leu 
    450                 455                 460                 


Asn Ser Val Asp Phe Arg Leu Lys Ile Thr Arg Met Gly Gly Glu Gly 
465                 470                 475                 480 


Leu Leu Pro Pro Asn Val Gly Leu Leu Tyr Val Gly Gly Tyr Glu Arg 
                485                 490                 495     


Pro Phe Ala Gln Ile Lys Val Thr Lys Glu Leu Lys Gln Tyr Asp Asn 
            500                 505                 510         


Lys Ile Ile Glu Cys Lys Phe Glu Asn Asn Ser Trp Val Phe Met Arg 
        515                 520                 525             


Gln Arg Thr Asp Lys Ser Phe Pro Asn Ala Tyr Asn Thr Ala Met Ala 
    530                 535                 540                 


Val Cys Asn Ser Ile Ser Asn Pro Val Thr Lys Glu Met Leu Phe Glu 
545                 550                 555                 560 


Phe Ile Asp Arg Cys Thr Ala Ala Ser Gln Gly Gln Lys Arg Lys His 
                565                 570                 575     


His Leu Asp Pro Asp Thr Glu Leu Met Pro Pro Pro Pro Pro Lys Arg 
            580                 585                 590         


Pro Arg Pro Leu Thr 
        595         


<210>  1235
<211>  2061
<212>  DNA
<213>  Homosapiens

<400>  1235
tgttccgcga tcttctcagg ctctcctagc agcatccatc gccgccaccc tatcttcact     60

ggcttcacct tctccttctc tcttcgttgc tgagcgacaa gcttcctagc gctatgactg    120

tcgtctccgt cccgcagcgg gagccgctcg tcctgggtgg ccgccttgcg ccgcttggct    180

tttcctcccg aggttacttt ggggccctcc cgatggtgac cacggctccg cctcctttac    240

cccggatccc ggacccccgg gcactgcccc cgaccctctt cctccctcat ttcctagggg    300

gagatggccc gtgtctgacc ccccagcctc gcgctccagc agctctgccc aaccgcagcc    360

tcgccgtggc gggaggcact cctcgggcag cgccgaagaa gcggcgaaag aagaaggtgc    420

gggccagccc cgcagggcag ctgcccagcc gcttccacca gtaccagcag caccggccga    480

gtctggaggg cggccggagc cccgcgaccg gcccgagcgg agcgcaggag gtcccgggcc    540

cggccgccgc cttggccccg agtcctgcag ccgcagccgg cacggaggga gccagccccg    600

accttgcccc gctgcggccc gcggctcccg gccaaacccc cctcaggaaa gaggttttaa    660

aatcaaagat gggaaaatcg gagaaaattg cccttcccca tggccagctt gttcatggta    720

tacacttgta tgagcaacca aagataaaca gacagaaaag caaatataac ttgccactaa    780

ccaagatcac ctctgcaaaa agaaatgaaa acaacttttg gcaggattct gtttcatctg    840

acagaattca gaagcaggaa aaaaagcctt ttaaaaatac cgagaacatt aaaaattcgc    900

atttgaagaa atcagcattt ctaactgaag tgagccaaaa ggaaaattat gctggggcaa    960

agtttagtga tccaccttct cctagtgttc ttccaaagcc tcctagtcac tggatgggaa   1020

gcactgttga aaattccaac caaaacaggg agctgatggc agtacactta aaaaccctcc   1080

tcaaagttca aacttagatt tcagatttca gtatgtgtgt aaaacataat ttttcccata   1140

tccctggact cttgagaaaa ttggtacaga aatggaaatt tgccttgttg caacatacaa   1200

ttgcaaaaga tgagtttaaa aaattacata caaacagctt gtattatatt ttatattttg   1260

taaatactgt ataccatgta ttatgtgtat attgttcata cttgagaggt atattatagt   1320

tttgttatga aagtatgtat tttgccctgc ccacattgca ggtgttttgt atatatacaa   1380

tggataaatt ttaagtgtgt gctaaggcac atggaagacc gattttattt gcacaaggta   1440

ctgagatttt tttcaagaaa cagctgtcaa atctcaaggt gaagatctaa atgtgaacag   1500

tttactaatg cactactgaa gtttaaatct gtggcacaat caatgtaagc atggggtttg   1560

tttctctaaa ttgatttgta atctgaaatt actgaacaac tcctattccc atttttgcta   1620

aactcaattt ctggttttgg tatatatcca ttccagctta atgcctctaa ttttaatgcc   1680

aacaaaattg gttgtaatca aattttaaaa taataataat ttggcccccc cttttaaaat   1740

agtcttgact ctttgtgtgt gactgtttct catgtttgaa tgtgtgacta ggagatgatt   1800

ttgtgtggtt ggattttttt gacttctact ttactggctg agtgtgagcc gccatgcctg   1860

gccataatct acattttctt accaggagca gcattgaggt ttttgagcat agtacttgac   1920

tactctagag gctgagacgg gagcatctct tgagcctgag aagtggagat tgcaattgag   1980

ctaggatcag gccactgcac tccagcctgg gtaacagacg ctgtctcaaa aaaaaggcca   2040

agagaaagta agggagacag a                                             2061


<210>  1236
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1236

Met Thr Val Val Ser Val Pro Gln Arg Glu Pro Leu Val Leu Gly Gly 
1               5                   10                  15      


Arg Leu Ala Pro Leu Gly Phe Ser Ser Arg Gly Tyr Phe Gly Ala Leu 
            20                  25                  30          


Pro Met Val Thr Thr Ala Pro Pro Pro Leu Pro Arg Ile Pro Asp Pro 
        35                  40                  45              


Arg Ala Leu Pro Pro Thr Leu Phe Leu Pro His Phe Leu Gly Gly Asp 
    50                  55                  60                  


Gly Pro Cys Leu Thr Pro Gln Pro Arg Ala Pro Ala Ala Leu Pro Asn 
65                  70                  75                  80  


Arg Ser Leu Ala Val Ala Gly Gly Thr Pro Arg Ala Ala Pro Lys Lys 
                85                  90                  95      


Arg Arg Lys Lys Lys Val Arg Ala Ser Pro Ala Gly Gln Leu Pro Ser 
            100                 105                 110         


Arg Phe His Gln Tyr Gln Gln His Arg Pro Ser Leu Glu Gly Gly Arg 
        115                 120                 125             


Ser Pro Ala Thr Gly Pro Ser Gly Ala Gln Glu Val Pro Gly Pro Ala 
    130                 135                 140                 


Ala Ala Leu Ala Pro Ser Pro Ala Ala Ala Ala Gly Thr Glu Gly Ala 
145                 150                 155                 160 


Ser Pro Asp Leu Ala Pro Leu Arg Pro Ala Ala Pro Gly Gln Thr Pro 
                165                 170                 175     


Leu Arg Lys Glu Val Leu Lys Ser Lys Met Gly Lys Ser Glu Lys Ile 
            180                 185                 190         


Ala Leu Pro His Gly Gln Leu Val His Gly Ile His Leu Tyr Glu Gln 
        195                 200                 205             


Pro Lys Ile Asn Arg Gln Lys Ser Lys Tyr Asn Leu Pro Leu Thr Lys 
    210                 215                 220                 


Ile Thr Ser Ala Lys Arg Asn Glu Asn Asn Phe Trp Gln Asp Ser Val 
225                 230                 235                 240 


Ser Ser Asp Arg Ile Gln Lys Gln Glu Lys Lys Pro Phe Lys Asn Thr 
                245                 250                 255     


Glu Asn Ile Lys Asn Ser His Leu Lys Lys Ser Ala Phe Leu Thr Glu 
            260                 265                 270         


Val Ser Gln Lys Glu Asn Tyr Ala Gly Ala Lys Phe Ser Asp Pro Pro 
        275                 280                 285             


Ser Pro Ser Val Leu Pro Lys Pro Pro Ser His Trp Met Gly Ser Thr 
    290                 295                 300                 


Val Glu Asn Ser Asn Gln Asn Arg Glu Leu Met Ala Val His Leu Lys 
305                 310                 315                 320 


Thr Leu Leu Lys Val Gln Thr 
                325         


<210>  1237
<211>  1012
<212>  DNA
<213>  Homosapiens

<400>  1237
agcgggctta ggccgagggg tgggggtcgc gccgggggcc ggcggagctc ctgtggtggt     60

agcagcggta gcgggagacg gagcgagtcc agcggccgcg ggcagacccg gagggaacgg    120

aggaagcggt catgtctcgc tacacgaggc cccccaacac ctccctgttc atcaggaacg    180

tcgcggacgc caccaggcct gaggacttgc gccgtgagtt tggtcgatat ggccctatag    240

tagacgttta cattccactt gacttctaca ctcgccgccc aagaggattt gcttatgttc    300

aatttgaaga tgttcgaggt gctgaagatg ctctttataa cctcaataga aagtgggtat    360

gtggccgtca gattgaaata cagtttgcac aaggtgatcg caaaacacca ggccaaatga    420

aatcaaaaga acgtcatcct tgttctccaa gtgatcacag gagatcaaga agccccagcc    480

aaagaagaac tcgaagtaga agttcttcat ggggaagaaa taggaggcgg tcagacagcc    540

ttaaagagtc tcgacacagg cgattttctt atagcaagtc taaatctcgt tccaaatcat    600

taccaaggcg gtctacctca gcaaggcagt caagaactcc aagaaggaat tttggctcta    660

gaggacggtc aaggtccaag tccttacaaa agaggtccaa gtcaatagga aaatcacagt    720

caagttcacc tcaaaagcag actagctcag gaacaaaatc aagatcacat ggaagacatt    780

ctgactcaat agcaagatcc ccgtgtaaat ctcccaaagg gtataccaat tctgaaacta    840

aagtacaaac agcaaagcat tctcattttc ggtcacattc cagatctcga agttatcgtc    900

ataaaaacag ttggtgaaca gcaacagaaa gagcaccacg ccgtctttaa tataagttat    960

taaactctca ttatgttaaa taaaaattct ttaaggcaaa aaaaaaaaaa aa           1012


<210>  1238
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  1238

Met Ser Arg Tyr Thr Arg Pro Pro Asn Thr Ser Leu Phe Ile Arg Asn 
1               5                   10                  15      


Val Ala Asp Ala Thr Arg Pro Glu Asp Leu Arg Arg Glu Phe Gly Arg 
            20                  25                  30          


Tyr Gly Pro Ile Val Asp Val Tyr Ile Pro Leu Asp Phe Tyr Thr Arg 
        35                  40                  45              


Arg Pro Arg Gly Phe Ala Tyr Val Gln Phe Glu Asp Val Arg Gly Ala 
    50                  55                  60                  


Glu Asp Ala Leu Tyr Asn Leu Asn Arg Lys Trp Val Cys Gly Arg Gln 
65                  70                  75                  80  


Ile Glu Ile Gln Phe Ala Gln Gly Asp Arg Lys Thr Pro Gly Gln Met 
                85                  90                  95      


Lys Ser Lys Glu Arg His Pro Cys Ser Pro Ser Asp His Arg Arg Ser 
            100                 105                 110         


Arg Ser Pro Ser Gln Arg Arg Thr Arg Ser Arg Ser Ser Ser Trp Gly 
        115                 120                 125             


Arg Asn Arg Arg Arg Ser Asp Ser Leu Lys Glu Ser Arg His Arg Arg 
    130                 135                 140                 


Phe Ser Tyr Ser Lys Ser Lys Ser Arg Ser Lys Ser Leu Pro Arg Arg 
145                 150                 155                 160 


Ser Thr Ser Ala Arg Gln Ser Arg Thr Pro Arg Arg Asn Phe Gly Ser 
                165                 170                 175     


Arg Gly Arg Ser Arg Ser Lys Ser Leu Gln Lys Arg Ser Lys Ser Ile 
            180                 185                 190         


Gly Lys Ser Gln Ser Ser Ser Pro Gln Lys Gln Thr Ser Ser Gly Thr 
        195                 200                 205             


Lys Ser Arg Ser His Gly Arg His Ser Asp Ser Ile Ala Arg Ser Pro 
    210                 215                 220                 


Cys Lys Ser Pro Lys Gly Tyr Thr Asn Ser Glu Thr Lys Val Gln Thr 
225                 230                 235                 240 


Ala Lys His Ser His Phe Arg Ser His Ser Arg Ser Arg Ser Tyr Arg 
                245                 250                 255     


His Lys Asn Ser Trp 
            260     


<210>  1239
<211>  4708
<212>  DNA
<213>  Homosapiens

<400>  1239
gggtcctgga ggcctctggg cgcgtgcgcg ggcggtcgct acctgcggcc gagccaggga     60

gcgagagggc gcagagggca gcgggcttgg gcagcatgag gcccggaggg gagcggcccg    120

tggaaggggg cgcgtgcaat ggccgctccg agctggagct actgaagctg cgctcggcgg    180

agtgcatcga cgaggcggcc gagcggctgg gggccctgag ccgcgcgatc tggagccagc    240

ccgagctggc ctacgaggag caccatgccc accgcgtgct gacgcacttc ttcgagcggg    300

agccgcccgc ggcctcctgg gcagtgcagc cgcactacca gctgcccacg gccttccgcg    360

ccgagtggga gccgccggag gcccgggcac cgagcgccac gccacgcccg ctgcacctgg    420

gcttcctctg cgagtacgac gcgctgcccg gcatcggcca cgcctgcggc cacaacctca    480

tcgctgaggt cggggcggcg gccgcgctgg gcgtgagggg ggccttagag ggcctcccca    540

ggccgcctcc gcccgtgaag gtagttgtcc tgggaacccc tgcagaagaa gatggtggtg    600

gcaaaattga tttaattgaa gcaggggctt ttacaaatct tgatgttgtt tttatggccc    660

acccatcaca agagaatgct gcttatctac cagatatggc tgaacatgat gtgactgtga    720

aatactatgg aaaagcatct cattctgctt cttatccctg ggaaggatta aatgcattag    780

atgctgctgt gctggcctat aacaatctgt ctgtgttcag acagcaaatg aaaccaacct    840

ggagagttca tggtataata aaaaatggtg gtgtaaaacc caatatcatt ccctcttatt    900

ctgaattaat ctattacttc cgtgcaccct caatgaaaga acttcaagtt ttgaccaaaa    960

aggcagaaga ttgcttcaga gctgcagctt tggcttcagg gtgcacagtg gaaattaaag   1020

gtggagcaca tgattattac aatgttcttc ccaataagag cctatggaaa gcctatatgg   1080

aaaatggaag aaagctagga atagagttca tttcagaaga tacaatgttg aatggccctt   1140

caggatctac ggattttgga aatgttagtt ttgtggttcc tggaattcat ccatattttc   1200

acattggatc taatgccttg aatcatactg aacagtacac tgaagctgct gggtcacagg   1260

aagctcagtt ctacactctg cggacggcca aagctctggc aatgacggca ctggatgtta   1320

tttttaaacc agagttactg gaaggaatca gagaggactt taaactgaaa cttcaagaag   1380

aacagtttgt aaatgcagta gaataaaaga cttaggggcc acttataaat caagaagacg   1440

tgatgatttt tttcttttaa tctcttttaa tgaaggcatg cttgtttttt aatcttaaag   1500

gagtaaaatt ctttttacct gataagtgag gacagggtgt ggagaaaaca tattaattac   1560

ctcatatcta aagtgaaaat ttttgcaaat ccgtacttga taggattatg atattacagg   1620

agctggtatg tgatgccatt ctttcttttt ttttaccccg caaccactca ccttcacagt   1680

agtgatacca tttcttaacc tggaggatac atggcatcat ttttataaaa tatgttagta   1740

aacctttttg taagccttaa atgttatgtg tatttttaaa agcttaagag atttcaaacc   1800

ttatattcag aattgacacc catgagagtg ttttgtggta tagggtggta aacttgttct   1860

ctaatcgtat attaattcct ctaccagatt gtatatttga agccagtgtc tttccttttt   1920

ttgttttaag atagagcctc gctctgttgc ccaggctgaa gtgtagtggc acaatctcgg   1980

ctcactgcaa cctctgcctc ccaggttcaa gtgattctcc tgcctcagcc taccaagtag   2040

ctgggattac aggtgtgtgg caccatgccc agctaatttt tgtattttta gtagagacgg   2100

catttcacca tgttggccag gctggtctcg aactcctgac ctcaggtgat gcacctgcct   2160

cggcctccta aagtgctggg attacaggca tgagccaccg cacccggcct gccagtgtct   2220

ttttaataca catgtgtgtt ggtattttta aattgttaca gtatctagca tattgcttac   2280

tctgaatatt cagtactttt tgaataagca aatattgctt ccttgcttgg aatcatcaga   2340

gtttaaagta gcttcgtgga tggaccatga tcctaagatg agttttaatt ttgtgtttac   2400

agtcatctct tgtacaacgt ggagaagaaa agatatactt actactttgc ttcaggtaca   2460

cataagaaaa cctctttttt aaaaaaattt ttattttttt acataataga gacaggggct   2520

cgctgtagct tccaggctgg cctcaaactc ctgggctcaa gcaatcctcc tgtcttggcc   2580

tcccaaagtg ttgggatttc aggtatgaga caccacacct gcccattttt gtttggtttt   2640

ttaatgggca ggttcttgct ctcccaggct ggagtgcagt ggtgtaatca cagctcactg   2700

cagtctcgaa ctcctggact caagcagtcc tcccacctca gcctcctaaa gcactgggat   2760

tacaggcttg aggcactgca cctggccctg accatttttt aaaaaggtta ggcttagtgc   2820

aaagtttaaa attatatgat tcttaaaata ctgaattagt ttctaaacta aactagaggt   2880

ataggtggac ctgcttgagg tatctttgtt tttatggaac atttttatta catgccttta   2940

taatttttca ttgttcacac cctgtactga aacctttttc tcaaatacca actcttggct   3000

atgttaaatt tgtagacttt aaaagatgtt atctaaatta atggtttaaa tatacaaatt   3060

gaaaatattt tctttttagt ggcaatttta aaagcaggcc ttaatatggg acctgctttt   3120

aaagtaaaat atgtggtact atgaattact aaattgctat ataccatgta atagtgagta   3180

tagctaatat ttagtatgcc ttttaaaaat tttggactgc ttttcggttt taacaaattc   3240

tccacatgtg aactactcaa gaaattttcc ctttttaatt gcctctatag cactcataag   3300

agctagggca ttaggataaa ctagaatatt ttatgtttat gaatacttgt ataaacttaa   3360

aagtgttttg atttcccaca atttcccaaa ggaatgttta tttattaaga gttgtgttga   3420

taatttaact gttacaattt cagcagttga attcagtgaa cactggttga ggagtgccta   3480

tttctaagca ctgggtgtaa gaagaaaaga cacttgcaaa ggaagagcta agattaacat   3540

aatttctttg gtttttctat tgcttgttat tattatgtaa aaactgggtg gcagttcaca   3600

aggaagattg ttgtaacaga agagtgacaa ccaatagttt tttgatcatt aaatcaaatt   3660

ttgtaaacag tggcaggagc gtggacttaa aacaaggctt gcttatttgg ttttgtcaaa   3720

gttttacgaa aatatatgat atatatttat actaaaacta tataatcctt agatttagga   3780

aagcaatcag ttaatgtctt tagcacacta aagcagtatt aaacacaggt acaagttgga   3840

aattgtagaa aactgaaaga aaacaagaca aaatgtctat ggtagggaat aaaagagttt   3900

aagatattat gtaaaattat gtgtattttc ttctctttta cataaattgt ttgtgaaaag   3960

tgtgctcaac ttttttacaa gagtgatatt aacttggatt tatttttcaa tataatttgg   4020

agaccctttg ttatccaaat aaaattgatg agtttctgtg cctgtaaaaa aaaaaaaaaa   4080

aaaaagaaaa gaaaagacac tgttgcatgc cccagaaagc ttgtggtggg tggtaagttc   4140

tcacgagatt tatttatctg agcaacattg ggactgaggg aacatctgaa agctaccatc   4200

ttgaaaattt ttgaggaagt gtttctgaaa tatttaaaaa tacttaagtc agtcattttg   4260

aacaaaagaa attgatacaa taagtttttt tttttaagga tgattgtcta attttgtaat   4320

atgttgtttt ttaaaaacct gtctgatggt gttttataca tttctaactt tttacctgag   4380

ttatctcttt agtcttttgg aaaataccct acacaatact aacctttaaa actatcaaat   4440

ttttgttata agataaatgt tatctttgta ctagatagca accctttata aggttgtaag   4500

gtataataaa ctgcttattt ttttacatac ttcatatcaa gcattttgca gtccaattat   4560

atagttgagg atggtgtatt ttgatatgta tgaagttaat attttcaagt aagcaatcag   4620

tctactacca tcagattata agcttttttg taataatagg tacataaaat gtgtatgaaa   4680

aatctacaat aaacatgttt atctgata                                      4708


<210>  1240
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  1240

Met Arg Pro Gly Gly Glu Arg Pro Val Glu Gly Gly Ala Cys Asn Gly 
1               5                   10                  15      


Arg Ser Glu Leu Glu Leu Leu Lys Leu Arg Ser Ala Glu Cys Ile Asp 
            20                  25                  30          


Glu Ala Ala Glu Arg Leu Gly Ala Leu Ser Arg Ala Ile Trp Ser Gln 
        35                  40                  45              


Pro Glu Leu Ala Tyr Glu Glu His His Ala His Arg Val Leu Thr His 
    50                  55                  60                  


Phe Phe Glu Arg Glu Pro Pro Ala Ala Ser Trp Ala Val Gln Pro His 
65                  70                  75                  80  


Tyr Gln Leu Pro Thr Ala Phe Arg Ala Glu Trp Glu Pro Pro Glu Ala 
                85                  90                  95      


Arg Ala Pro Ser Ala Thr Pro Arg Pro Leu His Leu Gly Phe Leu Cys 
            100                 105                 110         


Glu Tyr Asp Ala Leu Pro Gly Ile Gly His Ala Cys Gly His Asn Leu 
        115                 120                 125             


Ile Ala Glu Val Gly Ala Ala Ala Ala Leu Gly Val Arg Gly Ala Leu 
    130                 135                 140                 


Glu Gly Leu Pro Arg Pro Pro Pro Pro Val Lys Val Val Val Leu Gly 
145                 150                 155                 160 


Thr Pro Ala Glu Glu Asp Gly Gly Gly Lys Ile Asp Leu Ile Glu Ala 
                165                 170                 175     


Gly Ala Phe Thr Asn Leu Asp Val Val Phe Met Ala His Pro Ser Gln 
            180                 185                 190         


Glu Asn Ala Ala Tyr Leu Pro Asp Met Ala Glu His Asp Val Thr Val 
        195                 200                 205             


Lys Tyr Tyr Gly Lys Ala Ser His Ser Ala Ser Tyr Pro Trp Glu Gly 
    210                 215                 220                 


Leu Asn Ala Leu Asp Ala Ala Val Leu Ala Tyr Asn Asn Leu Ser Val 
225                 230                 235                 240 


Phe Arg Gln Gln Met Lys Pro Thr Trp Arg Val His Gly Ile Ile Lys 
                245                 250                 255     


Asn Gly Gly Val Lys Pro Asn Ile Ile Pro Ser Tyr Ser Glu Leu Ile 
            260                 265                 270         


Tyr Tyr Phe Arg Ala Pro Ser Met Lys Glu Leu Gln Val Leu Thr Lys 
        275                 280                 285             


Lys Ala Glu Asp Cys Phe Arg Ala Ala Ala Leu Ala Ser Gly Cys Thr 
    290                 295                 300                 


Val Glu Ile Lys Gly Gly Ala His Asp Tyr Tyr Asn Val Leu Pro Asn 
305                 310                 315                 320 


Lys Ser Leu Trp Lys Ala Tyr Met Glu Asn Gly Arg Lys Leu Gly Ile 
                325                 330                 335     


Glu Phe Ile Ser Glu Asp Thr Met Leu Asn Gly Pro Ser Gly Ser Thr 
            340                 345                 350         


Asp Phe Gly Asn Val Ser Phe Val Val Pro Gly Ile His Pro Tyr Phe 
        355                 360                 365             


His Ile Gly Ser Asn Ala Leu Asn His Thr Glu Gln Tyr Thr Glu Ala 
    370                 375                 380                 


Ala Gly Ser Gln Glu Ala Gln Phe Tyr Thr Leu Arg Thr Ala Lys Ala 
385                 390                 395                 400 


Leu Ala Met Thr Ala Leu Asp Val Ile Phe Lys Pro Glu Leu Leu Glu 
                405                 410                 415     


Gly Ile Arg Glu Asp Phe Lys Leu Lys Leu Gln Glu Glu Gln Phe Val 
            420                 425                 430         


Asn Ala Val Glu 
        435     


<210>  1241
<211>  2475
<212>  DNA
<213>  Homosapiens

<400>  1241
ctctctacac agaatcggct gttgagtgtg ctctcagtgg agctttggtt ttagctgttc     60

tctgacaaag agcttgttct gagctgcaca tctcgtcctc tttgttcagc ctcaggcttc    120

aagcattgaa tcctaaatat tctccagctg ggaatcagac aagggcagaa atgaagaacc    180

cagaagccca gcaggatgtt tcagtttccc agggatttcg catgttgttt tacacgatga    240

aacccagtga aacttcattc caaacattag aagaggtgcc tgattatgta aaaaaggcaa    300

ctccattttt catttctttg atgctgcttg aacttgttgt cagctggatt ctcaaaggaa    360

agccaccagg tcgcctggat gatgctttaa cgtcaatctc agctggtgtt ctgtctcgac    420

ttccaagtct atttttcagg agcattgaac tgaccagtta tatttatatc tgggagaact    480

acaggctgtt caatttgcct tgggattctc catggacttg gtattcagcc ttcttaggag    540

ttgactttgg ctactactgg ttccatcgta tggctcatga agttaatatt atgtgggccg    600

gacaccaaac acatcatagt tctgaagact ataacttatc cacagcactg agacagtctg    660

tcctccagat atatacttcc tggattttct actctcccct ggccctcttc ataccccctt    720

cagtatatgc tgttcatctt caattcaatc ttctttacca attttggatc catacagagg    780

tcatcaataa ccttggtcct ttggaactga ttcttaatac tcctagccat catagggttc    840

atcatggcag aaatcgttat tgcatagaca aaaattatgc tggtgttctt attatttggg    900

ataaaatttt tgggacattt gaagcagaaa atgaaaaagt tgtatatggc ttaacacatc    960

ccattaatac atttgaacca atcaaagtgc agttccatca cttattttcc atatggacta   1020

cattctgggc cacacctgga ttcttcaata agttttctgt catatttaag ggaccgggat   1080

ggggtccagg taaaccaaga cttggtctca gtgaagaaat tccagaggtc accggcaaag   1140

aagttccctt ctcatcatct tcatctcagc tattaaagat atatacagtt gtacagtttg   1200

ctctgatgtt ggcattttat gaagagacct ttgcagatac agctgcactg tcgcaagtta   1260

ctctccttct gagggtttgc ttcattatcc tgaccttgac ttccattgga tttcttctgg   1320

atcaaagacc caaggcagct attatggaaa ctctccgttg cttgatgttc ttaatgctgt   1380

accgatttgg tcacctgaag cctcttgtcc cttcattgtc atctgctttt gagattgttt   1440

tttccatttg cattgctttc tggggagtta gaagcatgaa acaactcacc tctcaccctt   1500

ggaaataacc tgaatttgta cataattctc ttcttttaat gagttgtcca cacgcatatt   1560

atgactgcat attaaaatgt aattatttta tgtaatgctt atatgaacta tttcttcaat   1620

gaaaagtaaa attacttatt tactattgtt tgcctttcac atttgttatt ttctattaaa   1680

aattaaagtc agttttggtt acttcccccc tttactacaa ttaaaaaaag atttcaaata   1740

taatgatgtt atattaactg atagccttat atgacaagta taaaaagaag ggatgaaact   1800

taaaaacagt aaaaacaaga aggaatattg cctttacatc aatttgaaaa caatgtttcc   1860

tttgatgttt gctaaaatta tgcatagata catgtttgta gtcataaaaa tgtattacat   1920

tggttgtctt cctaaggcca cagttacctt tgcaatccat ataacctaag aagctgcatt   1980

ccagaaaaag acatcactga ggccaggcgc ggtggctcac ccctgtaatc ccagcacttt   2040

gtggggctga ggtgggcgga tcatgaggtc cagagataga gaccatcctg gccaacatgg   2100

tgaagtcctg tctctactaa aaatataaaa atttagctgg acatggtggt gtgcgcctgt   2160

agtcccagct actctggagg ctgaggcagg agaatcgctt gaacctggga ggcagaagtt   2220

ggagtgagtg gagattgcac cactgcactc cagcctgggc gacagagcga gactccgtct   2280

caaagaaaaa agacatcact gaaagaaaaa tgaacagaat ttgtcagaat tagttttttc   2340

aacaggttac tttgtcatac atttctctaa tatgcttggt caatttgttt tggcagactg   2400

ggcagcatgc agcaattctg cattatttaa agttatcaga acaatgttaa ttctctaaat   2460

aaaattaccc aaggt                                                    2475


<210>  1242
<211>  445
<212>  PRT
<213>  Homosapiens

<400>  1242

Met Lys Asn Pro Glu Ala Gln Gln Asp Val Ser Val Ser Gln Gly Phe 
1               5                   10                  15      


Arg Met Leu Phe Tyr Thr Met Lys Pro Ser Glu Thr Ser Phe Gln Thr 
            20                  25                  30          


Leu Glu Glu Val Pro Asp Tyr Val Lys Lys Ala Thr Pro Phe Phe Ile 
        35                  40                  45              


Ser Leu Met Leu Leu Glu Leu Val Val Ser Trp Ile Leu Lys Gly Lys 
    50                  55                  60                  


Pro Pro Gly Arg Leu Asp Asp Ala Leu Thr Ser Ile Ser Ala Gly Val 
65                  70                  75                  80  


Leu Ser Arg Leu Pro Ser Leu Phe Phe Arg Ser Ile Glu Leu Thr Ser 
                85                  90                  95      


Tyr Ile Tyr Ile Trp Glu Asn Tyr Arg Leu Phe Asn Leu Pro Trp Asp 
            100                 105                 110         


Ser Pro Trp Thr Trp Tyr Ser Ala Phe Leu Gly Val Asp Phe Gly Tyr 
        115                 120                 125             


Tyr Trp Phe His Arg Met Ala His Glu Val Asn Ile Met Trp Ala Gly 
    130                 135                 140                 


His Gln Thr His His Ser Ser Glu Asp Tyr Asn Leu Ser Thr Ala Leu 
145                 150                 155                 160 


Arg Gln Ser Val Leu Gln Ile Tyr Thr Ser Trp Ile Phe Tyr Ser Pro 
                165                 170                 175     


Leu Ala Leu Phe Ile Pro Pro Ser Val Tyr Ala Val His Leu Gln Phe 
            180                 185                 190         


Asn Leu Leu Tyr Gln Phe Trp Ile His Thr Glu Val Ile Asn Asn Leu 
        195                 200                 205             


Gly Pro Leu Glu Leu Ile Leu Asn Thr Pro Ser His His Arg Val His 
    210                 215                 220                 


His Gly Arg Asn Arg Tyr Cys Ile Asp Lys Asn Tyr Ala Gly Val Leu 
225                 230                 235                 240 


Ile Ile Trp Asp Lys Ile Phe Gly Thr Phe Glu Ala Glu Asn Glu Lys 
                245                 250                 255     


Val Val Tyr Gly Leu Thr His Pro Ile Asn Thr Phe Glu Pro Ile Lys 
            260                 265                 270         


Val Gln Phe His His Leu Phe Ser Ile Trp Thr Thr Phe Trp Ala Thr 
        275                 280                 285             


Pro Gly Phe Phe Asn Lys Phe Ser Val Ile Phe Lys Gly Pro Gly Trp 
    290                 295                 300                 


Gly Pro Gly Lys Pro Arg Leu Gly Leu Ser Glu Glu Ile Pro Glu Val 
305                 310                 315                 320 


Thr Gly Lys Glu Val Pro Phe Ser Ser Ser Ser Ser Gln Leu Leu Lys 
                325                 330                 335     


Ile Tyr Thr Val Val Gln Phe Ala Leu Met Leu Ala Phe Tyr Glu Glu 
            340                 345                 350         


Thr Phe Ala Asp Thr Ala Ala Leu Ser Gln Val Thr Leu Leu Leu Arg 
        355                 360                 365             


Val Cys Phe Ile Ile Leu Thr Leu Thr Ser Ile Gly Phe Leu Leu Asp 
    370                 375                 380                 


Gln Arg Pro Lys Ala Ala Ile Met Glu Thr Leu Arg Cys Leu Met Phe 
385                 390                 395                 400 


Leu Met Leu Tyr Arg Phe Gly His Leu Lys Pro Leu Val Pro Ser Leu 
                405                 410                 415     


Ser Ser Ala Phe Glu Ile Val Phe Ser Ile Cys Ile Ala Phe Trp Gly 
            420                 425                 430         


Val Arg Ser Met Lys Gln Leu Thr Ser His Pro Trp Lys 
        435                 440                 445 


<210>  1243
<211>  3186
<212>  DNA
<213>  Homosapiens

<400>  1243
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac     60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct    120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg    180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc    240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta    300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa    360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt    420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg    480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa    540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc    600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc    660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca    720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag    780

gatgatttcc cccttcgaaa aactgcctct gagcccaact tgaaggtgcg gtccaggtta    840

aaacagaaag tggcagagag gagaagcagc cccttactca ggcggaagga tggaaatgtt    900

gtcacttcat tcaagaagcg aatgtttgag gtgacagaat cctcagtcag tagcagttct    960

ccaggctctg gtcccagttc accaaacaat gggccaactg gaagtgttac tgaaaatgag   1020

acttcggttt tgccccctac ccctcatgcc gagcaaatgg tttcacagca acgcattcta   1080

attcatgaag attccatgaa cctgctaagt ctttatacct ctccttcttt gcccaacatt   1140

accttggggc ttcccgcagt gccatcccag ctcaatgctt cgaattcact caaagaaaag   1200

cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc   1260

agcatcccgg catcttccag ccaccctcat gttactttag agggaaagcc acccaacagc   1320

agccaccagg ctctcctgca gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt   1380

cttgtagctg gtggagttcc cttacatcct cagtctccct tggcaacaaa agagagaatt   1440

tcacctggca ttagaggtac ccacaaattg ccccgtcaca gacccctgaa ccgaacccag   1500

tctgcacctt tgcctcagag cacgttggct cagctggtca ttcaacagca acaccagcaa   1560

ttcttggaga agcagaagca ataccagcag cagatccaca tgaacaaact gctttcgaaa   1620

tctattgaac aactgaagca accaggcagt caccttgagg aagcagagga agagcttcag   1680

ggggaccagg cgatgcagga agacagagcg ccctctagtg gcaacagcac taggagcgac   1740

agcagtgctt gtgtggatga cacactggga caagttgggg ctgtgaaggt caaggaggaa   1800

ccagtggaca gtgatgaaga tgctcagatc caggaaatgg aatctgggga gcaggctgct   1860

tttatgcaac agcctttcct ggaacccacg cacacacgtg cgctctctgt gcgccaagct   1920

ccgctggctg cggttggcat ggatggatta gagaaacacc gtctcgtctc caggactcac   1980

tcttcccctg ctgcctctgt tttacctcac ccagcaatgg accgccccct ccagcctggc   2040

tctgcaactg gaattgccta tgaccccttg atgctgaaac accagtgcgt ttgtggcaat   2100

tccaccaccc accctgagca tgctggacga atacagagta tctggtcacg actgcaagaa   2160

actgggctgc taaataaatg tgagcgaatt caaggtcgaa aagccagcct ggaggaaata   2220

cagcttgttc attctgaaca tcactcactg ttgtatggca ccaaccccct ggacggacag   2280

aagctggacc ccaggatact cctaggtgat gactctcaaa agtttttttc ctcattacct   2340

tgtggtggac ttggggtgga cagtgacacc atttggaatg agctacactc gtccggtgct   2400

gcacgcatgg ctgttggctg tgtcatcgag ctggcttcca aagtggcctc aggagagctg   2460

aagaatgggt ttgctgttgt gaggccccct ggccatcacg ctgaagaatc cacagccatg   2520

gggttctgct tttttaattc agttgcaatt accgccaaat acttgagaga ccaactaaat   2580

ataagcaaga tattgattgt agatctggat gttcaccatg gaaacggtac ccagcaggcc   2640

ttttatgctg accccagcat cctgtacatt tcactccatc gctatgatga agggaacttt   2700

ttccctggca gtggagcccc aaatgaggtt ggaacaggcc ttggagaagg gtacaatata   2760

aatattgcct ggacaggtgg ccttgatcct cccatgggag atgttgagta ccttgaagca   2820

ttcaggacca tcgtgaagcc tgtggccaaa gagtttgatc cagacatggt cttagtatct   2880

gctggatttg atgcattgga aggccacacc cctcctctag gagggtacaa agtgacggca   2940

aaatgttttg gtcatttgac gaagcaattg atgacattgg ctgatggacg tgtggtgttg   3000

gctctagaag gaggacatga tctcacagcc atctgtgatg catcagaagc ctgtgtaaat   3060

gcccttctag gaaatgagct ggagccactt gcagaagata ttctccacca aagcccgaat   3120

atgaatgctg ttatttcttt acagaagatc attgaaattc aaagtatgtc tttaaagttc   3180

tcttaa                                                              3186


<210>  1244
<211>  1011
<212>  PRT
<213>  Homosapiens

<400>  1244

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Pro Phe 
                565                 570                 575     


Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln Ala Pro Leu 
            580                 585                 590         


Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu Val Ser Arg 
        595                 600                 605             


Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro Ala Met Asp 
    610                 615                 620                 


Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr Asp Pro Leu 
625                 630                 635                 640 


Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr His Pro Glu 
                645                 650                 655     


His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly 
            660                 665                 670         


Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala Ser Leu Glu 
        675                 680                 685             


Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu Tyr Gly Thr 
    690                 695                 700                 


Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu Leu Gly Asp 
705                 710                 715                 720 


Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly Leu Gly Val 
                725                 730                 735     


Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly Ala Ala Arg 
            740                 745                 750         


Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val Ala Ser Gly 
        755                 760                 765             


Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala 
    770                 775                 780                 


Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile 
785                 790                 795                 800 


Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys Ile Leu Ile 
                805                 810                 815     


Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr 
            820                 825                 830         


Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr Asp Glu Gly 
        835                 840                 845             


Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Gly Thr Gly Leu 
    850                 855                 860                 


Gly Glu Gly Tyr Asn Ile Asn Ile Ala Trp Thr Gly Gly Leu Asp Pro 
865                 870                 875                 880 


Pro Met Gly Asp Val Glu Tyr Leu Glu Ala Phe Arg Thr Ile Val Lys 
                885                 890                 895     


Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu Val Ser Ala Gly 
            900                 905                 910         


Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly Gly Tyr Lys Val 
        915                 920                 925             


Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu Met Thr Leu Ala 
    930                 935                 940                 


Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala 
945                 950                 955                 960 


Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu Leu Gly Asn Glu 
                965                 970                 975     


Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro Asn Met Asn 
            980                 985                 990         


Ala Val Ile Ser Leu Gln Lys Ile  Ile Glu Ile Gln Ser  Met Ser Leu 
        995                 1000                 1005             


Lys Phe  Ser 
    1010     


<210>  1245
<211>  2790
<212>  DNA
<213>  Homosapiens

<400>  1245
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac     60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct    120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg    180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc    240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta    300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa    360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt    420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg    480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa    540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc    600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc    660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca    720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag    780

gatgatttcc cccttcgaaa aactgcctct gagcccaact tgaaggtgcg gtccaggtta    840

aaacagaaag tggcagagag gagaagcagc cccttactca ggcggaagga tggaaatgtt    900

gtcacttcat tcaagaagcg aatgtttgag gtgacagaat cctcagtcag tagcagttct    960

ccaggctctg gtcccagttc accaaacaat gggccaactg gaagtgttac tgaaaatgag   1020

acttcggttt tgccccctac ccctcatgcc gagcaaatgg tttcacagca acgcattcta   1080

attcatgaag attccatgaa cctgctaagt ctttatacct ctccttcttt gcccaacatt   1140

accttggggc ttcccgcagt gccatcccag ctcaatgctt cgaattcact caaagaaaag   1200

cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc   1260

agcatcccgg catcttccag ccaccctcat gttactttag agggaaagcc acccaacagc   1320

agccaccagg ctctcctgca gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt   1380

cttgtagctg gtggagttcc cttacatcct cagtctccct tggcaacaaa agagagaatt   1440

tcacctggca ttagaggtac ccacaaattg ccccgtcaca gacccctgaa ccgaacccag   1500

tctgcacctt tgcctcagag cacgttggct cagctggtca ttcaacagca acaccagcaa   1560

ttcttggaga agcagaagca ataccagcag cagatccaca tgaacaaact gctttcgaaa   1620

tctattgaac aactgaagca accaggcagt caccttgagg aagcagagga agagcttcag   1680

ggggaccagg cgatgcagga agacagagcg ccctctagtg gcaacagcac taggagcgac   1740

agcagtgctt gtgtggatga cacactggga caagttgggg ctgtgaaggt caaggaggaa   1800

ccagtggaca gtgatgaaga tgctcagatc caggaaatgg aatctgggga gcaggctgct   1860

tttatgcaac agcctttcct ggaacccacg cacacacgtg cgctctctgt gcgccaagct   1920

ccgctggctg cggttggcat ggatggatta gagaaacacc gtctcgtctc caggactcac   1980

tcttcccctg ctgcctctgt tttacctcac ccagcaatgg accgccccct ccagcctggc   2040

tctgcaactg gaattgccta tgaccccttg atgctgaaac accagtgcgt ttgtggcaat   2100

tccaccaccc accctgagca tgctggacga atacagagta tctggtcacg actgcaagaa   2160

actgggctgc taaataaatg tgagcgaatt caaggtcgaa aagccagcct ggaggaaata   2220

cagcttgttc attctgaaca tcactcactg ttgtatggca ccaaccccct ggacggacag   2280

aagctggacc ccaggatact cctaggtgat gactctcaaa agtttttttc ctcattacct   2340

tgtggtggac ttggggtgga cagtgacacc atttggaatg agctacactc gtccggtgct   2400

gcacgcatgg ctgttggctg tgtcatcgag ctggcttcca aagtggcctc aggagagctg   2460

aagaatgggt ttgctgttgt gaggccccct ggccatcacg ctgaagaatc cacagccatg   2520

gggttctgct tttttaattc agttgcaatt accgccaaat acttgagaga ccaactaaat   2580

ataagcaaga tattgattgt agatctggat gttcaccatg gaaacggtac ccagcaggcc   2640

ttttatgctg accccagcat cctgtacatt tcactccatc gctatgatga agggaacttt   2700

ttccctggca gtggagcccc aaatgaggtt cggtttattt ctttagagcc ccacttttat   2760

ttgtatcttt caggtaattg cattgcatga                                    2790


<210>  1246
<211>  879
<212>  PRT
<213>  Homosapiens

<400>  1246

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Pro Phe 
                565                 570                 575     


Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln Ala Pro Leu 
            580                 585                 590         


Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu Val Ser Arg 
        595                 600                 605             


Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro Ala Met Asp 
    610                 615                 620                 


Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr Asp Pro Leu 
625                 630                 635                 640 


Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr His Pro Glu 
                645                 650                 655     


His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly 
            660                 665                 670         


Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala Ser Leu Glu 
        675                 680                 685             


Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu Tyr Gly Thr 
    690                 695                 700                 


Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu Leu Gly Asp 
705                 710                 715                 720 


Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly Leu Gly Val 
                725                 730                 735     


Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly Ala Ala Arg 
            740                 745                 750         


Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val Ala Ser Gly 
        755                 760                 765             


Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala 
    770                 775                 780                 


Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile 
785                 790                 795                 800 


Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys Ile Leu Ile 
                805                 810                 815     


Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr 
            820                 825                 830         


Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr Asp Glu Gly 
        835                 840                 845             


Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Arg Phe Ile Ser 
    850                 855                 860                 


Leu Glu Pro His Phe Tyr Leu Tyr Leu Ser Gly Asn Cys Ile Ala 
865                 870                 875                 


<210>  1247
<211>  4659
<212>  DNA
<213>  Homosapiens

<400>  1247
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac     60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct    120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg    180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc    240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta    300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa    360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt    420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg    480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa    540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc    600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc    660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca    720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag    780

gatgatttcc cccttcgaaa aactgcctct gagcccaact tgaaggtgcg gtccaggtta    840

aaacagaaag tggcagagag gagaagcagc cccttactca ggcggaagga tggaaatgtt    900

gtcacttcat tcaagaagcg aatgtttgag gtgacagaat cctcagtcag tagcagttct    960

ccaggctctg gtcccagttc accaaacaat gggccaactg gaagtgttac tgaaaatgag   1020

acttcggttt tgccccctac ccctcatgcc gagcaaatgg tttcacagca acgcattcta   1080

attcatgaag attccatgaa cctgctaagt ctttatacct ctccttcttt gcccaacatt   1140

accttggggc ttcccgcagt gccatcccag ctcaatgctt cgaattcact caaagaaaag   1200

cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc   1260

agcatcccgg catcttccag ccaccctcat gttactttag agggaaagcc acccaacagc   1320

agccaccagg ctctcctgca gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt   1380

cttgtagctg gtggagttcc cttacatcct cagtctccct tggcaacaaa agagagaatt   1440

tcacctggca ttagaggtac ccacaaattg ccccgtcaca gacccctgaa ccgaacccag   1500

tctgcacctt tgcctcagag cacgttggct cagctggtca ttcaacagca acaccagcaa   1560

ttcttggaga agcagaagca ataccagcag cagatccaca tgaacaaact gctttcgaaa   1620

tctattgaac aactgaagca accaggcagt caccttgagg aagcagagga agagcttcag   1680

ggggaccagg cgatgcagga agacagagcg ccctctagtg gcaacagcac taggagcgac   1740

agcagtgctt gtgtggatga cacactggga caagttgggg ctgtgaaggt caaggaggaa   1800

ccagtggaca gtgatgaaga tgctcagatc caggaaatgg aatctgggga gcaggctgct   1860

tttatgcaac agcctttcct ggaacccacg cacacacgtg cgctctctgt gcgccaagct   1920

ccgctggctg cggttggcat ggatggatta gagaaacacc gtctcgtctc caggactcac   1980

tcttcccctg ctgcctctgt tttacctcac ccagcaatgg accgccccct ccagcctggc   2040

tctgcaactg gaattgccta tgaccccttg atgctgaaac accagtgcgt ttgtggcaat   2100

tccaccaccc accctgagca tgctggacga atacagagta tctggtcacg actgcaagaa   2160

actgggctgc taaataaatg tgagcgaatt caaggtcgaa aagccagcct ggaggaaata   2220

cagcttgttc attctgaaca tcactcactg ttgtatggca ccaaccccct ggacggacag   2280

aagctggacc ccaggatact cctaggtgat gactctcaaa agtttttttc ctcattacct   2340

tgtggtggac ttggggtgga cagtgacacc atttggaatg agctacactc gtccggtgct   2400

gcacgcatgg ctgttggctg tgtcatcgag ctggcttcca aagtggcctc aggagagctg   2460

aagaatgggt ttgctgttgt gaggccccct ggccatcacg ctgaagaatc cacagccatg   2520

gggttctgct tttttaattc agttgcaatt accgccaaat acttgagaga ccaactaaat   2580

ataagcaaga tattgattgt agatctggat gttcaccatg gaaacggtac ccagcaggcc   2640

ttttatgctg accccagcat cctgtacatt tcactccatc gctatgatga agggaacttt   2700

ttccctggca gtggagcccc aaatgaggtt ggaacaggcc ttggagaagg gtacaatata   2760

aatattgcct ggacaggtgg ccttgatcct cccatgggag atgttgagta ccttgaagca   2820

ttcaggacca tcgtgaagcc tgtggccaaa gagtttgatc cagacatggt cttagtatct   2880

gctggatttg atgcattgga aggccacacc cctcctctag gagggtacaa agtgacggca   2940

aaatgttttg gtcatttgac gaagcaattg atgacattgg ctgatggacg tgtggtgttg   3000

gctctagaag gaggacatga tctcacagcc atctgtgatg catcagaagc ctgtgtaaat   3060

gcccttctag gaaatgagct ggagccactt gcagaagata ttctccacca aagcccgaat   3120

atgaatgctg ttatttcttt acagaagatc attgaaattc aaagcaagta ttggaagtca   3180

gtaaggatgg tggctgtgcc aaggggctgt gctctggctg gtgctcagtt gcaagaggag   3240

acagagaccg tttctgccct ggcctcccta acagtggatg tggaacagcc ctttgctcag   3300

gaagacagca gaactgctgg tgagcctatg gaagaggagc cagccttgtg aagtgccaag   3360

tccccctctg atatttcctg tgtgtgacat cattgtgtat ccccccaccc cagtaccctc   3420

agacatgtct tgtctgctgc ctgggtggca cagattcaat ggaacataaa cactgggcac   3480

aaaattctga acagcagctt cacttgttct ttggatggac ttgaaagggc attaaagatt   3540

ccttaaacgt aaccgctgtg attctagagt tacagtaaac cacgattgga agaaactgct   3600

tccagcatgc ttttaatatg ctgggtgacc cactcctaga caccaagttt gaactagaaa   3660

cattcagtac agcactagat attgttaatt tcagaagcta tgacagccag tgaaattttg   3720

ggcaaaacct gagacatagt cattcctgac attctgatca gctttttttg gggtaatttg   3780

tttttcaaac agtcttaact tgtttacaag atttgctttt agctatgaac ggatcgtaat   3840

tccacccaga atgtaatgtt tcttgtttgt ttgttttgtt ttgttagggt ttttttctca   3900

actttaacac acagttcaac tgttcctagt aaaagttcaa gatggaggaa ctagcatgag   3960

gcttttttca gtatctcgaa gtccaaatgc caaaggaacc tcacacactg tttgtaatgg   4020

tgcaatattt tatatcactt ttttttaaac atccccaaca tctttgtgtt ctcacacaca   4080

ggcaatttgc aatgttgcaa ttgtgttgga gaatgaagtc cccccacctc ccagccacac   4140

acacatcctt tgttctcatg acagtaggtc tgagcaaatg ttccaccaag cattttcagt   4200

gtctttgaaa agcacgtaac ttttcaaagg tggtcttaat ttgttgcata tctatcaagg   4260

acttattcac tcacctttcc ttttctgccc tctatcaatt gatttcttct tacctttcat   4320

cattcattcc ttcctttaga aaaactgaag attacccata atctcctctt attacttgag   4380

ggccttgact atttagttta ttttgtttac tttacaggtt aacacagttg ttttgtctga   4440

ttgcatttta ttaactgtga agccgttgaa atgaatatca cttaagcaac gttgctaaat   4500

ttctatgtgt ttgaaatgtg ttaatgaagg cactgcttat ttgtagtcac cttgaactga   4560

cttaacctag aagctgtgcc ttcttgtgaa aaaaaaaaaa aacaaaaaca aaaaacagcc   4620

tttaaacaag tttccttagt gtcaaaagtt aaaaataaa                          4659


<210>  1248
<211>  1066
<212>  PRT
<213>  Homosapiens

<400>  1248

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Pro Phe 
                565                 570                 575     


Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln Ala Pro Leu 
            580                 585                 590         


Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu Val Ser Arg 
        595                 600                 605             


Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro Ala Met Asp 
    610                 615                 620                 


Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr Asp Pro Leu 
625                 630                 635                 640 


Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr His Pro Glu 
                645                 650                 655     


His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly 
            660                 665                 670         


Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala Ser Leu Glu 
        675                 680                 685             


Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu Tyr Gly Thr 
    690                 695                 700                 


Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu Leu Gly Asp 
705                 710                 715                 720 


Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly Leu Gly Val 
                725                 730                 735     


Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly Ala Ala Arg 
            740                 745                 750         


Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val Ala Ser Gly 
        755                 760                 765             


Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala 
    770                 775                 780                 


Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile 
785                 790                 795                 800 


Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys Ile Leu Ile 
                805                 810                 815     


Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr 
            820                 825                 830         


Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr Asp Glu Gly 
        835                 840                 845             


Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Gly Thr Gly Leu 
    850                 855                 860                 


Gly Glu Gly Tyr Asn Ile Asn Ile Ala Trp Thr Gly Gly Leu Asp Pro 
865                 870                 875                 880 


Pro Met Gly Asp Val Glu Tyr Leu Glu Ala Phe Arg Thr Ile Val Lys 
                885                 890                 895     


Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu Val Ser Ala Gly 
            900                 905                 910         


Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly Gly Tyr Lys Val 
        915                 920                 925             


Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu Met Thr Leu Ala 
    930                 935                 940                 


Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala 
945                 950                 955                 960 


Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu Leu Gly Asn Glu 
                965                 970                 975     


Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro Asn Met Asn 
            980                 985                 990         


Ala Val Ile Ser Leu Gln Lys Ile  Ile Glu Ile Gln Ser  Lys Tyr Trp 
        995                 1000                 1005             


Lys Ser  Val Arg Met Val Ala  Val Pro Arg Gly Cys  Ala Leu Ala 
    1010                 1015                 1020             


Gly Ala  Gln Leu Gln Glu Glu  Thr Glu Thr Val Ser  Ala Leu Ala 
    1025                 1030                 1035             


Ser Leu  Thr Val Asp Val Glu  Gln Pro Phe Ala Gln  Glu Asp Ser 
    1040                 1045                 1050             


Arg Thr  Ala Gly Glu Pro Met  Glu Glu Glu Pro Ala  Leu 
    1055                 1060                 1065     


<210>  1249
<211>  4238
<212>  DNA
<213>  Homosapiens

<400>  1249
ggggaagaga ggcacagaca cagataggag aagggcaccg gctggagcca cttgcaggac     60

tgagggtttt tgcaacaaaa ccctagcagc ctgaagaact ctaagccaga tggggtggct    120

ggacgagagc agctcttggc tcagcaaaga atgcacagta tgatcagctc agtggatgtg    180

aagtcagaag ttcctgtggg cctggagccc atctcacctt tagacctaag gacagacctc    240

aggatgatga tgcccgtggt ggaccctgtt gtccgtgaga agcaattgca gcaggaatta    300

cttcttatcc agcagcagca acaaatccag aagcagcttc tgatagcaga gtttcagaaa    360

cagcatgaga acttgacacg gcagcaccag gctcagcttc aggagcatat caaggaactt    420

ctagccataa aacagcaaca agaactccta gaaaaggagc agaaactgga gcagcagagg    480

caagaacagg aagtagagag gcatcgcaga gaacagcagc ttcctcctct cagaggcaaa    540

gatagaggac gagaaagggc agtggcaagt acagaagtaa agcagaagct tcaagagttc    600

ctactgagta aatcagcaac gaaagacact ccaactaatg gaaaaaatca ttccgtgagc    660

cgccatccca agctctggta cacggctgcc caccacacat cattggatca aagctctcca    720

ccccttagtg gaacatctcc atcctacaag tacacattac caggagcaca agatgcaaag    780

gatgatttcc cccttcgaaa aactgcctct gagcccaact tgaaggtgcg gtccaggtta    840

aaacagaaag tggcagagag gagaagcagc cccttactca ggcggaagga tggaaatgtt    900

gtcacttcat tcaagaagcg aatgtttgag gtgacagaat cctcagtcag tagcagttct    960

ccaggctctg gtcccagttc accaaacaat gggccaactg gaagtgttac tgaaaatgag   1020

acttcggttt tgccccctac ccctcatgcc gagcaaatgg tttcacagca acgcattcta   1080

attcatgaag attccatgaa cctgctaagt ctttatacct ctccttcttt gcccaacatt   1140

accttggggc ttcccgcagt gccatcccag ctcaatgctt cgaattcact caaagaaaag   1200

cagaagtgtg agacgcagac gcttaggcaa ggtgttcctc tgcctgggca gtatggaggc   1260

agcatcccgg catcttccag ccaccctcat gttactttag agggaaagcc acccaacagc   1320

agccaccagg ctctcctgca gcatttatta ttgaaagaac aaatgcgaca gcaaaagctt   1380

cttgtagctg gtggagttcc cttacatcct cagtctccct tggcaacaaa agagagaatt   1440

tcacctggca ttagaggtac ccacaaattg ccccgtcaca gacccctgaa ccgaacccag   1500

tctgcacctt tgcctcagag cacgttggct cagctggtca ttcaacagca acaccagcaa   1560

ttcttggaga agcagaagca ataccagcag cagatccaca tgaacaaact gctttcgaaa   1620

tctattgaac aactgaagca accaggcagt caccttgagg aagcagagga agagcttcag   1680

ggggaccagg cgatgcagga agacagagcg ccctctagtg gcaacagcac taggagcgac   1740

agcagtgctt gtgtggatga cacactggga caagttgggg ctgtgaaggt caaggaggaa   1800

ccagtggaca gtgatgaaga tgctcagatc caggaaatgg aatctgggga gcaggctgct   1860

tttatgcaac aggtaatagg caaagattta gctccaggat ttgtaattaa agtcattatc   1920

tgaacatgaa atgcattgca ggtttggtaa atggatatga tttcctatca gtttatattt   1980

ctctatgatt tgagttcagt gtttaaggat tctacctaat gcagatatat gtatatatct   2040

atatagaggt ctttctatat actgatctct atatagatat caatgtttca ttgaaaatcc   2100

actggtaagg aaatacctgt tatactaaaa ttatgataca taatatctga gcagttaata   2160

ggctttaaat ttatcccaaa gcctgctaca ccaattactt ctaaagaaaa caaattcact   2220

gttattttga gtttatgtgt tgagatcagt gactgctgga tagtctccca gtctgatcaa   2280

tgaagcattc gattagtttt tgattttttg caacatctag aatttaattt tcacatcact   2340

gtacataatg tatcatacta tagtcttgaa cactgttaaa ggtagtctgc cccttccttc   2400

ctctctcttt ttttagttaa gtagaaatgt tctggtcacc atgccagtag tcctaggtta   2460

ttgtgtaggt tgcaattgaa catattagga atacaggtgg ttttaaatat atagatgcaa   2520

attgcagcac tactttaaat attagattat gtctcacata gcactgctca ttttactttt   2580

attttgtgta atttgatgac actgtctatc aaaaaagagc aaatgaagca gatgcaaatg   2640

ttagtgagaa gtaatgtgca gcattatggt ccaatcagat acaatattgt gtctacaatt   2700

gcaaaaaaca cagtaacagg atgaatatta tctgatatca agtcaaaatc agtttgaaaa   2760

gaaggtgtat catattttat attgtcacta gaatctctta agtataattc cataatgaca   2820

tgggcatata ccgtaacatt ctggcaaata acaattagaa aagataggtt taacaaaaaa   2880

atttacttgt atataatgca ccttcaggag gactatgtcc tttgatgcta taaaatacaa   2940

acaactttga aggcaacaga agacactgtt tattcaagtc agttctttgt caggttcctg   3000

ctgttctcct acagaaaagt gattctgtga gggtgaacag gaaatgcctt gtggaaacag   3060

gaagtccaag tgattcatgt actgaggaat gtaggaaaaa aaatctgagg atagtgcttt   3120

actctttctg tttttaaagg gcactctatg aattgattta ttgtctaaga aaataacacc   3180

acaagtaggg aaattgttac ggaagctttt cactggaaca tttccttcat attccctttt   3240

gatatgttta ccttgtttta taggtttact tttgttaagc tagttaaagg ttcgttgtat   3300

taagacccct ttaatatgga taatccaaat tgacctagaa tctttgtgag gttttttcta   3360

ttaaaatatt tatatttcta aatccgaggt atttcaaggt gtagtatcct atttcaaagg   3420

agatatagca gttttgccaa atgtagacat tgttcaactg tatgttattg gcacgtgttg   3480

tttacatttt gctgtgacat ttaaaaatat ttctttaaaa atgttactgc taaagataca   3540

ttatcctttt ttaaaaagtc tccattcaaa ttaaattaac ataactagaa gttagaaagt   3600

ttaaaagttt tccacataat gaaagtcctt ctgataattt gacaaatagc tataatagga   3660

acactcccta tcaccaacat attttggtta gtatattcct tcatattaaa atgacttttt   3720

gtcagttgtt ttgcattaaa aatatggcat gcctaagata aaattgtata ttttttccat   3780

ctcataaata ttcattttct tcaaagtctt ttttcaatct cataaaaaag ggatagtgca   3840

tcttttaaaa tacattttat ttggggagga acatgtggct gagcagactt ttgtataata   3900

ttacttcaaa gatatgtaat cacaaacaaa aaaaactatt ttttataatg tcatttgaga   3960

gagtttcatc agtacagttg gtggacgtta attgtttgaa tttgatagtc tttgaattta   4020

atcaagaaac tacctggaac cagtgaaaag gaaagctgga cttaaataat cttagaatta   4080

attgataaat gtctctttta aaatctactg tatttattat aatttacacc cttgaaggtg   4140

atctcttgtt ttgtgttgta aatatattgt ttgtatgttt cccttcttgc cttctgttat   4200

aagtctcttc ctttctcaaa taaagttttt tttaaaag                           4238


<210>  1250
<211>  590
<212>  PRT
<213>  Homosapiens

<400>  1250

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln 
                85                  90                  95      


Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu 
            100                 105                 110         


Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg 
        115                 120                 125             


Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys 
    130                 135                 140                 


Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr 
145                 150                 155                 160 


Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp 
                165                 170                 175     


Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu 
            180                 185                 190         


Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp 
        195                 200                 205             


Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu 
    210                 215                 220                 


Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys 
                245                 250                 255     


Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly 
            260                 265                 270         


Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu 
        275                 280                 285             


Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val 
    290                 295                 300                 


Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser 
305                 310                 315                 320 


Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala 
                325                 330                 335     


Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys 
            340                 345                 350         


Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr 
        355                 360                 365             


Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu 
    370                 375                 380                 


Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu 
385                 390                 395                 400 


Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val 
                405                 410                 415     


Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro 
            420                 425                 430         


Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg 
        435                 440                 445             


Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile 
    450                 455                 460                 


Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln 
465                 470                 475                 480 


Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys 
                485                 490                 495     


Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp 
            500                 505                 510         


Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg 
        515                 520                 525             


Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala 
    530                 535                 540                 


Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile 
545                 550                 555                 560 


Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Val Ile 
                565                 570                 575     


Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val Ile Ile 
            580                 585                 590 


<210>  1251
<211>  3210
<212>  DNA
<213>  Homosapiens

<400>  1251
atgcacagta tgatcagctc agtggatgtg aagtcagaag ttcctgtggg cctggagccc     60

atctcacctt tagacctaag gacagacctc aggatgatga tgcccgtggt ggaccctgtt    120

gtccgtgaga agcaattgca gcaggaatta cttcttatcc agcagcagca acaaatccag    180

aagcagcttc tgatagcaga gtttcagaaa cagcatgaga acttgacacg gcagcaccag    240

gctcagcttc aggagcatat caagttgcaa caggaacttc tagccataaa acagcaacaa    300

gaactcctag aaaaggagca gaaactggag cagcagaggc aagaacagga agtagagagg    360

catcgcagag aacagcagct tcctcctctc agaggcaaag atagaggacg agaaagggca    420

gtggcaagta cagaagtaaa gcagaagctt caagagttcc tactgagtaa atcagcaacg    480

aaagacactc caactaatgg aaaaaatcat tccgtgagcc gccatcccaa gctctggtac    540

acggctgccc accacacatc attggatcaa agctctccac cccttagtgg aacatctcca    600

tcctacaagt acacattacc aggagcacaa gatgcaaagg atgatttccc ccttcgaaaa    660

actgcctctg agcccaactt gaaggtgcgg tccaggttaa aacagaaagt ggcagagagg    720

agaagcagcc ccttactcag gcggaaggat ggaaatgttg tcacttcatt caagaagcga    780

atgtttgagg tgacagaatc ctcagtcagt agcagttctc caggctctgg tcccagttca    840

ccaaacaatg ggccaactgg aagtgttact gaaaatgaga cttcggtttt gccccctacc    900

cctcatgccg agcaaatggt ttcacagcaa cgcattctaa ttcatgaaga ttccatgaac    960

ctgctaagtc tttatacctc tccttctttg cccaacatta ccttggggct tcccgcagtg   1020

ccatcccagc tcaatgcttc gaattcactc aaagaaaagc agaagtgtga gacgcagacg   1080

cttaggcaag gtgttcctct gcctgggcag tatggaggca gcatcccggc atcttccagc   1140

caccctcatg ttactttaga gggaaagcca cccaacagca gccaccaggc tctcctgcag   1200

catttattat tgaaagaaca aatgcgacag caaaagcttc ttgtagctgg tggagttccc   1260

ttacatcctc agtctccctt ggcaacaaaa gagagaattt cacctggcat tagaggtacc   1320

cacaaattgc cccgtcacag acccctgaac cgaacccagt ctgcaccttt gcctcagagc   1380

acgttggctc agctggtcat tcaacagcaa caccagcaat tcttggagaa gcagaagcaa   1440

taccagcagc agatccacat gaacaaactg ctttcgaaat ctattgaaca actgaagcaa   1500

ccaggcagtc accttgagga agcagaggaa gagcttcagg gggaccaggc gatgcaggaa   1560

gacagagcgc cctctagtgg caacagcact aggagcgaca gcagtgcttg tgtggatgac   1620

acactgggac aagttggggc tgtgaaggtc aaggaggaac cagtggacag tgatgaagat   1680

gctcagatcc aggaaatgga atctggggag caggctgctt ttatgcaaca gcctttcctg   1740

gaacccacgc acacacgtgc gctctctgtg cgccaagctc cgctggctgc ggttggcatg   1800

gatggattag agaaacaccg tctcgtctcc aggactcact cttcccctgc tgcctctgtt   1860

ttacctcacc cagcaatgga ccgccccctc cagcctggct ctgcaactgg aattgcctat   1920

gaccccttga tgctgaaaca ccagtgcgtt tgtggcaatt ccaccaccca ccctgagcat   1980

gctggacgaa tacagagtat ctggtcacga ctgcaagaaa ctgggctgct aaataaatgt   2040

gagcgaattc aaggtcgaaa agccagcctg gaggaaatac agcttgttca ttctgaacat   2100

cactcactgt tgtatggcac caaccccctg gacggacaga agctggaccc caggatactc   2160

ctaggtgatg actctcaaaa gtttttttcc tcattacctt gtggtggact tggggtggac   2220

agtgacacca tttggaatga gctacactcg tccggtgctg cacgcatggc tgttggctgt   2280

gtcatcgagc tggcttccaa agtggcctca ggagagctga agaatgggtt tgctgttgtg   2340

aggccccctg gccatcacgc tgaagaatcc acagccatgg ggttctgctt ttttaattca   2400

gttgcaatta ccgccaaata cttgagagac caactaaata taagcaagat attgattgta   2460

gatctggatg ttcaccatgg aaacggtacc cagcaggcct tttatgctga ccccagcatc   2520

ctgtacattt cactccatcg ctatgatgaa gggaactttt tccctggcag tggagcccca   2580

aatgaggttg gaacaggcct tggagaaggg tacaatataa atattgcctg gacaggtggc   2640

cttgatcctc ccatgggaga tgttgagtac cttgaagcat tcaggaccat cgtgaagcct   2700

gtggccaaag agtttgatcc agacatggtc ttagtatctg ctggatttga tgcattggaa   2760

ggccacaccc ctcctctagg agggtacaaa gtgacggcaa aatgttttgg tcatttgacg   2820

aagcaattga tgacattggc tgatggacgt gtggtgttgg ctctagaagg aggacatgat   2880

ctcacagcca tctgtgatgc atcagaagcc tgtgtaaatg cccttctagg aaatgagctg   2940

gagccacttg cagaagatat tctccaccaa agcccgaata tgaatgctgt tatttcttta   3000

cagaagatca ttgaaattca aagcaagtat tggaagtcag taaggatggt ggctgtgcca   3060

aggggctgtg ctctggctgg tgctcagttg caagaggaga cagagaccgt ttctgccctg   3120

gcctccctaa cagtggatgt ggaacagccc tttgctcagg aagacagcag aactgctggt   3180

gagcctatgg aagaggagcc agccttgtga                                    3210


<210>  1252
<211>  1069
<212>  PRT
<213>  Homosapiens

<400>  1252

Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val 
1               5                   10                  15      


Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met 
            20                  25                  30          


Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln 
        35                  40                  45              


Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu 
    50                  55                  60                  


Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln 
65                  70                  75                  80  


Ala Gln Leu Gln Glu His Ile Lys Leu Gln Gln Glu Leu Leu Ala Ile 
                85                  90                  95      


Lys Gln Gln Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln 
            100                 105                 110         


Arg Gln Glu Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro 
        115                 120                 125             


Pro Leu Arg Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr 
    130                 135                 140                 


Glu Val Lys Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr 
145                 150                 155                 160 


Lys Asp Thr Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro 
                165                 170                 175     


Lys Leu Trp Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser 
            180                 185                 190         


Pro Pro Leu Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly 
        195                 200                 205             


Ala Gln Asp Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu 
    210                 215                 220                 


Pro Asn Leu Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg 
225                 230                 235                 240 


Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser 
                245                 250                 255     


Phe Lys Lys Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser 
            260                 265                 270         


Ser Pro Gly Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser 
        275                 280                 285             


Val Thr Glu Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu 
    290                 295                 300                 


Gln Met Val Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn 
305                 310                 315                 320 


Leu Leu Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly 
                325                 330                 335     


Leu Pro Ala Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu 
            340                 345                 350         


Lys Gln Lys Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro 
        355                 360                 365             


Gly Gln Tyr Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val 
    370                 375                 380                 


Thr Leu Glu Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln 
385                 390                 395                 400 


His Leu Leu Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala 
                405                 410                 415     


Gly Gly Val Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg 
            420                 425                 430         


Ile Ser Pro Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro 
        435                 440                 445             


Leu Asn Arg Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln 
    450                 455                 460                 


Leu Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln 
465                 470                 475                 480 


Tyr Gln Gln Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu 
                485                 490                 495     


Gln Leu Lys Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu 
            500                 505                 510         


Gln Gly Asp Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn 
        515                 520                 525             


Ser Thr Arg Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln 
    530                 535                 540                 


Val Gly Ala Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp 
545                 550                 555                 560 


Ala Gln Ile Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln 
                565                 570                 575     


Gln Pro Phe Leu Glu Pro Thr His Thr Arg Ala Leu Ser Val Arg Gln 
            580                 585                 590         


Ala Pro Leu Ala Ala Val Gly Met Asp Gly Leu Glu Lys His Arg Leu 
        595                 600                 605             


Val Ser Arg Thr His Ser Ser Pro Ala Ala Ser Val Leu Pro His Pro 
    610                 615                 620                 


Ala Met Asp Arg Pro Leu Gln Pro Gly Ser Ala Thr Gly Ile Ala Tyr 
625                 630                 635                 640 


Asp Pro Leu Met Leu Lys His Gln Cys Val Cys Gly Asn Ser Thr Thr 
                645                 650                 655     


His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln 
            660                 665                 670         


Glu Thr Gly Leu Leu Asn Lys Cys Glu Arg Ile Gln Gly Arg Lys Ala 
        675                 680                 685             


Ser Leu Glu Glu Ile Gln Leu Val His Ser Glu His His Ser Leu Leu 
    690                 695                 700                 


Tyr Gly Thr Asn Pro Leu Asp Gly Gln Lys Leu Asp Pro Arg Ile Leu 
705                 710                 715                 720 


Leu Gly Asp Asp Ser Gln Lys Phe Phe Ser Ser Leu Pro Cys Gly Gly 
                725                 730                 735     


Leu Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Leu His Ser Ser Gly 
            740                 745                 750         


Ala Ala Arg Met Ala Val Gly Cys Val Ile Glu Leu Ala Ser Lys Val 
        755                 760                 765             


Ala Ser Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly 
    770                 775                 780                 


His His Ala Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser 
785                 790                 795                 800 


Val Ala Ile Thr Ala Lys Tyr Leu Arg Asp Gln Leu Asn Ile Ser Lys 
                805                 810                 815     


Ile Leu Ile Val Asp Leu Asp Val His His Gly Asn Gly Thr Gln Gln 
            820                 825                 830         


Ala Phe Tyr Ala Asp Pro Ser Ile Leu Tyr Ile Ser Leu His Arg Tyr 
        835                 840                 845             


Asp Glu Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asn Glu Val Gly 
    850                 855                 860                 


Thr Gly Leu Gly Glu Gly Tyr Asn Ile Asn Ile Ala Trp Thr Gly Gly 
865                 870                 875                 880 


Leu Asp Pro Pro Met Gly Asp Val Glu Tyr Leu Glu Ala Phe Arg Thr 
                885                 890                 895     


Ile Val Lys Pro Val Ala Lys Glu Phe Asp Pro Asp Met Val Leu Val 
            900                 905                 910         


Ser Ala Gly Phe Asp Ala Leu Glu Gly His Thr Pro Pro Leu Gly Gly 
        915                 920                 925             


Tyr Lys Val Thr Ala Lys Cys Phe Gly His Leu Thr Lys Gln Leu Met 
    930                 935                 940                 


Thr Leu Ala Asp Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp 
945                 950                 955                 960 


Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Asn Ala Leu Leu 
                965                 970                 975     


Gly Asn Glu Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro 
            980                 985                 990         


Asn Met Asn Ala Val Ile Ser Leu  Gln Lys Ile Ile Glu  Ile Gln Ser 
        995                 1000                 1005             


Lys Tyr  Trp Lys Ser Val Arg  Met Val Ala Val Pro  Arg Gly Cys 
    1010                 1015                 1020             


Ala Leu  Ala Gly Ala Gln Leu  Gln Glu Glu Thr Glu  Thr Val Ser 
    1025                 1030                 1035             


Ala Leu  Ala Ser Leu Thr Val  Asp Val Glu Gln Pro  Phe Ala Gln 
    1040                 1045                 1050             


Glu Asp  Ser Arg Thr Ala Gly  Glu Pro Met Glu Glu  Glu Pro Ala 
    1055                 1060                 1065             


Leu 
    


<210>  1253
<211>  1669
<212>  DNA
<213>  Homosapiens

<400>  1253
gaggtataag agcctccaag tctgcagctc tcgcccaact cccagacacc tcgcgggctc     60

tgcagcaccg gcaccgtttc caggaggcct ggcggggtgt gcgtccagcc gttgggcgct    120

ttctttttgg acctcggggc catccacacc gtcccctccc cctcccgcct ccctccccgc    180

ctcccccgcg cgccctcccc gcggaggtcc ctcccgtccg tcctcctgct ctctcctccg    240

cgggccgcat cgcccgggcc ggcgccgcgc gcgggggaag ctggcgggct gaggcgcccc    300

gctcttctcc tctgccccgg gcccgcgagg ccacgcgtcg ccgctcgaga gatgatgcag    360

gacgtgtcca gctcgccagt ctcgccggcc gacgacagcc tgagcaacag cgaggaagag    420

ccagaccggc agcagccgcc gagcggcaag cgcgggggac gcaagcggcg cagcagcagg    480

cgcagcgcgg gcggcggcgc ggggcccggc ggagccgcgg gtgggggcgt cggaggcggc    540

gacgagccgg gcagcccggc ccagggcaag cgcggcaaga agtctgcggg ctgtggcggc    600

ggcggcggcg cgggcggcgg cggcggcagc agcagcggcg gcgggagtcc gcagtcttac    660

gaggagctgc agacgcagcg ggtcatggcc aacgtgcggg agcgccagcg cacccagtcg    720

ctgaacgagg cgttcgccgc gctgcggaag atcatcccca cgctgccctc ggacaagctg    780

agcaagattc agaccctcaa gctggcggcc aggtacatcg acttcctcta ccaggtcctc    840

cagagcgacg agctggactc caagatggca agctgcagct atgtggctca cgagcggctc    900

agctacgcct tctcggtctg gaggatggag ggggcctggt ccatgtccgc gtcccactag    960

caggcggagc cccccacccc ctcagcaggg ccggagacct agatgtcatt gtttccagag   1020

aaggagaaaa tggacagtct agagactctg gagctggata actaaaaata aaaatatatg   1080

ccaaagattt tcttggaaat tagaagagca aaatccaaat tcaaagaaac agggcgtggg   1140

gcgcactttt aaaagagaaa gcgagacagg cccgtggaca gtgattccca gacgggcagc   1200

ggcaccatcc tcacacctct gcattctgat agaagtctga acagttgttt gtgttttttt   1260

tttttttttt tttgacgaag aatgttttta tttttatttt tttcatgcat gcattctcaa   1320

gaggtcgtgc caatcagcca ctgaaaggaa aggcatcact atggactttc tctattttaa   1380

aatggtaaca atcagaggaa ctataagaac acctttagaa ataaaaatac tgggatcaaa   1440

ctggcctgca aaaccatagt cagttaattc tttttttcat ccttcctctg aggggaaaaa   1500

caaaaaaaaa cttaaaatac aaaaaacaac attctattta tttattgagg acccatggta   1560

aaatgcaaat agatccggtg tctaaatgca ttcatatttt tatgattgtt ttgtaaatat   1620

ctttgtatat ttttctgcaa taaataaata taaaaaattt agagaaaaa               1669


<210>  1254
<211>  202
<212>  PRT
<213>  Homosapiens

<400>  1254

Met Met Gln Asp Val Ser Ser Ser Pro Val Ser Pro Ala Asp Asp Ser 
1               5                   10                  15      


Leu Ser Asn Ser Glu Glu Glu Pro Asp Arg Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Lys Arg Gly Gly Arg Lys Arg Arg Ser Ser Arg Arg Ser Ala Gly Gly 
        35                  40                  45              


Gly Ala Gly Pro Gly Gly Ala Ala Gly Gly Gly Val Gly Gly Gly Asp 
    50                  55                  60                  


Glu Pro Gly Ser Pro Ala Gln Gly Lys Arg Gly Lys Lys Ser Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Ser Ser Gly 
                85                  90                  95      


Gly Gly Ser Pro Gln Ser Tyr Glu Glu Leu Gln Thr Gln Arg Val Met 
            100                 105                 110         


Ala Asn Val Arg Glu Arg Gln Arg Thr Gln Ser Leu Asn Glu Ala Phe 
        115                 120                 125             


Ala Ala Leu Arg Lys Ile Ile Pro Thr Leu Pro Ser Asp Lys Leu Ser 
    130                 135                 140                 


Lys Ile Gln Thr Leu Lys Leu Ala Ala Arg Tyr Ile Asp Phe Leu Tyr 
145                 150                 155                 160 


Gln Val Leu Gln Ser Asp Glu Leu Asp Ser Lys Met Ala Ser Cys Ser 
                165                 170                 175     


Tyr Val Ala His Glu Arg Leu Ser Tyr Ala Phe Ser Val Trp Arg Met 
            180                 185                 190         


Glu Gly Ala Trp Ser Met Ser Ala Ser His 
        195                 200         


<210>  1255
<211>  640
<212>  DNA
<213>  Homosapiens

<400>  1255
accagcaacc tcgcccctcc ctgcggaaaa ccgatgagag gcagggccaa gccgaagcga     60

tggcggccta tccggagagc tgcgtggaca ctacggtgct ggacttcgtc gcagacctgt    120

ccctggcctc cccgagacgc cctctcctct gcgacttcgc acccggggtc tccttggggg    180

acccagccct tgcgctccga gagggaagac ccaggaggat ggcgcggttt gaagaggggg    240

acccagaaga agaggagtgc gaagtggacc agggggacgg agaagaggag gaggaagagg    300

agcgcggaag aggtgtctcc ctattaggcc gccccaagag gaaaagggtg atcacctacg    360

cccagcgcca ggccgccaac atccgcgaaa ggaagcggat gttcaacctc aacgaggcct    420

ttgaccagct gcggaggaag gtgcccacgt ttgcttacga gaaaaggctg tcccggatcg    480

agaccctccg cctggccatc gtctatatct ccttcatgac cgagctcttg gagagctgtg    540

agaagaagga aagcggctga gcctggtgtg gagagtctgc ccttcctcgt ctggtagtgc    600

tggggtgtgt caggaccggg cactgggtga ggctaaaggg                          640


<210>  1256
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  1256

Met Ala Ala Tyr Pro Glu Ser Cys Val Asp Thr Thr Val Leu Asp Phe 
1               5                   10                  15      


Val Ala Asp Leu Ser Leu Ala Ser Pro Arg Arg Pro Leu Leu Cys Asp 
            20                  25                  30          


Phe Ala Pro Gly Val Ser Leu Gly Asp Pro Ala Leu Ala Leu Arg Glu 
        35                  40                  45              


Gly Arg Pro Arg Arg Met Ala Arg Phe Glu Glu Gly Asp Pro Glu Glu 
    50                  55                  60                  


Glu Glu Cys Glu Val Asp Gln Gly Asp Gly Glu Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Arg Gly Arg Gly Val Ser Leu Leu Gly Arg Pro Lys Arg Lys Arg 
                85                  90                  95      


Val Ile Thr Tyr Ala Gln Arg Gln Ala Ala Asn Ile Arg Glu Arg Lys 
            100                 105                 110         


Arg Met Phe Asn Leu Asn Glu Ala Phe Asp Gln Leu Arg Arg Lys Val 
        115                 120                 125             


Pro Thr Phe Ala Tyr Glu Lys Arg Leu Ser Arg Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Ile Val Tyr Ile Ser Phe Met Thr Glu Leu Leu Glu Ser Cys 
145                 150                 155                 160 


Glu Lys Lys Glu Ser Gly 
                165     


<210>  1257
<211>  5616
<212>  DNA
<213>  Homosapiens

<400>  1257
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat   1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt   1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat   1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa   1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc   1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg   1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag   1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc   1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac   1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga   2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac   2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg   2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg   2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg   2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct   2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg   2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt   2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa   2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg   2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc   2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt   2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg   2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg   2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc   2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg   2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc   3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata   3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc   3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac   3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac   3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc   3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg   3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt   3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact   3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc   3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg   3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat   3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc   3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc   3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta   3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc   3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac   3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta   4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac   4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat   4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg   4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag   4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag   4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt   4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta   4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga   4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta   4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt   4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag   4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc   4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt   4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg   4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca   4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc   4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc   5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag   5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg   5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc   5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg   5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg   5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc   5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca   5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca   5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa   5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                             5616


<210>  1258
<211>  1210
<212>  PRT
<213>  Homosapiens

<400>  1258

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  1259
<211>  2239
<212>  DNA
<213>  Homosapiens

<400>  1259
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat   1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt   1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat   1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa   1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc   1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg   1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag   1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc   1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac   1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga   2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac   2100

ctgtgccatc caaactgcac ctacgggtcc taataaatct tcactgtctg actttagtct   2160

cccactaaaa ctgcatttcc tttctacaat ttcaatttct ccctttgctt caaataaagt   2220

cctgacacta ttcatttga                                                2239


<210>  1260
<211>  628
<212>  PRT
<213>  Homosapiens

<400>  1260

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  1261
<211>  1595
<212>  DNA
<213>  Homosapiens

<400>  1261
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca caggtttgag ctgaattatc acatgaatat aaatgggaaa tcagtgtttt   1500

agagagagaa cttttcgaca tatttcctgt tcccttggaa taaaaacatt tcttctgaaa   1560

ttttaccgtt aaaaaaaaaa aaaaaaaaaa aaaaa                              1595


<210>  1262
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  1262

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  1263
<211>  2865
<212>  DNA
<213>  Homosapiens

<400>  1263
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat   1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt   1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat   1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa   1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc   1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg   1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag   1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc   1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac   1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga   2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac   2100

ctgtgccatc caaactgcac ctacgggcca ggaaatgaga gtctcaaagc catgttattc   2160

tgccttttta aactatcatc ctgtaatcaa agtaatgatg gcagcgtgtc ccaccagagc   2220

gggagcccag ctgctcagga gtcatgctta ggatggatcc cttctcttct gccgtcagag   2280

tttcagctgg gttggggtgg atgcagccac ctccatgcct ggccttctgc atctgtgatc   2340

atcacggcct cctcctgcca ctgagcctca tgccttcacg tgtctgttcc ccccgctttt   2400

cctttctgcc acccctgcac gtgggccgcc aggttcccaa gagtatccta cccatttcct   2460

tccttccact ccctttgcca gtgcctctca ccccaactag tagctaacca tcacccccag   2520

gactgacctc ttcctcctcg ctgccagatg attgttcaaa gcacagaatt tgtcagaaac   2580

ctgcagggac tccatgctgc cagccttctc cgtaattagc atggccccag tccatgcttc   2640

tagccttggt tccttctgcc cctctgtttg aaattctaga gccagctgtg ggacaattat   2700

ctgtgtcaaa agccagatgt gaaaacatct caataacaaa ctggctgctt tgttcaatgc   2760

tagaacaacg cctgtcacag agtagaaact caaaaatatt tgctgagtga atgaacaaat   2820

gaataaatgc ataataaata attaaccacc aatccaacat ccaga                   2865


<210>  1264
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  1264

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  1265
<211>  4353
<212>  DNA
<213>  Homosapiens

<400>  1265
gggctggcgc agcaggggcc ggtgaaatgc aggctgacga cggcgcgcca ggggctgagc     60

tcgccccggt cggcgacgcg cacacacctt gagtgacagc gacctcttct ctacaggttt    120

tccccgcggg agcgtggccc tagcgggcgt tcggttttct ttggaaatcg cggagggggc    180

tggccgggcg cagcgatccc caccccggga ctccagcccc ggccgtgcgc gtcgccgcgg    240

acgggctctg cgggccacgg ggaaggtgcg aggaggcgcg agcaggctgt gagccgctgg    300

gcgctcccgc gagcccgctc ctctccgtcg ggagcagggc aaaggcgcca ggaacagggc    360

agaggcacag cgcccaccgc ctctgcggcc gcctgatgtg cgagcagccc gcgacgaggc    420

agtgcacgct cagacgcccc gctcctcccg ccagcgcgcg gcctcgctcc tcctagagga    480

cgctctctgc gcgggccctc ggaggaggcg gcggcggggc gagctgcagc gccgggacag    540

gaggtttgtc cccgcccgcg cgccgtaccg cggcggagat gggcgagacc atgtcaaaga    600

ggctgaagct ccacctggga ggggaggcag aaatggagga acgggcgttc gtcaacccct    660

tcccggacta cgaggccgcc gccggggcgc tgctcgcctc cggagcggcc gaagagacag    720

gctgtgttcg tcccccggcg accacggatg agcccggcct cccttttcat caggacggga    780

agatcattca taatttcata agacggatcc agaccaaaat taaagatctt ctgcagcaaa    840

tggaagaagg gctgaagaca gctgatcccc atgactgctc tgcttatact ggctggacag    900

gcatagccct tttgtacctg cagttgtacc gggtcacatg tgaccaaacc tacctgctcc    960

gatccctgga ttacgtaaaa agaacacttc ggaatctgaa tggccgcagg gtcaccttcc   1020

tctgtgggga tgctggcccc ctggctgttg gagctgtgat ttatcacaaa ctcagaagtg   1080

actgtgagtc ccaggaatgt gtcacaaaac ttttgcagct ccagagatcg gttgtctgcc   1140

aagaatcaga ccttcctgat gagctgcttt atggacgggc aggttatctg tatgccttac   1200

tgtacctgaa cacagagata ggtccaggca ccgtgtgtga gtcagctatt aaagaggtag   1260

tcaatgctat tattgaatcg ggtaagactt tgtcaaggga agaaagaaaa acggagcgct   1320

gcccgctgtt gtaccagtgg caccggaagc agtacgttgg agcagcccat ggcatggctg   1380

gaatttacta tatgttaatg cagccggcag caaaagtgga ccaagaaacc ttgacagaaa   1440

tggtgaaacc cagtattgat tatgtgcgcc acaaaaaatt ccgatctggg aattacccat   1500

catcattaag caatgaaaca gaccggctgg tgcactggtg ccacggcgcc ccgggggtca   1560

tccacatgct catgcaggcg tacaaggtct ttaaggagga gaagtacttg aaagaggcca   1620

tggagtgtag cgatgtgatt tggcagcgag gtttgctgcg gaagggctac gggatatgcc   1680

atgggactgc tggcaacggc tattccttcc tgtcccttta ccgtctcacg caggataaga   1740

agtacctcta ccgagcttgc aagtttgcag agtggtgtct agattacgga gcacacgggt   1800

gccgcattcc tgacagaccc tattcgctct ttgaaggcat ggctggcgct attcactttc   1860

tctctgatgt cctgggacca gagacatcac ggtttccagc atttgaactt gactcttcga   1920

agagggatta aaaggtgcaa aaagacaact aaaataccca tttggaccaa aagccaccag   1980

attgcttagt gcctgacaca gaaacaactg ggaatcctga aagagaagca gacaccgtca   2040

caggcccctc tggttagact agcatgagtg accgaagcca tccatcaaca ttttctaaca   2100

gcaccctcat caatataaaa tatgacttct tcacatacag attctctgta gtgtttgcat   2160

gtttcttggt gtttgttgtc tccaggtgta agctgtttta aatggaaggc ccttctattc   2220

ctgagggctc agagctgacc atgcatgaat gtatggcagt gtccactttt ctgtataaaa   2280

tgtataaagt ggggtttctt ccatattgac aaatgaggga acaggtggtg tctatcttgt   2340

atatcagaaa gattatctag ggtctatcct agtgataata cattgtcagc cttttctgtg   2400

gcaccttcca gatgagaatg agggagcgac cactccaagg acggacagga ccagcagttc   2460

tgcaggggcg tgctggggtg gtttgggagt gcacagctga acgcttcccg tttggatttt   2520

acactcacct tcgtgtttta aagaagcctc agagtgcatt gcagctctgt cagggcccca   2580

ttcccagcag aggcttcagg tgctttgtgt agagtccagg gcagctggag ctttgttggg   2640

gagacttctg gacccaaagg gagctttccc aagaagcctt tgatggccac actgtaggca   2700

gcagtgacta agcactggca gttccagaac atttacccag gtatatgtta ctaaaacagg   2760

ctccacctca gtttatcaac attataagtt actgttctaa gaaaagtaaa tacagttcca   2820

gatgggttat tgcagattaa cagaaagaca ctcaactgga ctcatgtccc tgcaattaaa   2880

cttacttcaa ccttttggaa agttatcaaa atctaaattt ggaatgaatg catttcctat   2940

tttttgtcta cttttgggtg ataaaaagta ctagccctta tttatagata tgagaaacat   3000

aatgttctaa ccaacaacat tatggtattt gtgtgacttt tatttgaaaa aatgtgagca   3060

gtaatttggg ttagcctacc ttcattaatt ctatcacata gatttcagtt tttagaaggg   3120

tttctgtcat catggaagag gtggtctggg actaggtact tctcgtcttg tgagctaagg   3180

cttgtgtcat gaaagacaag aggcctctct taacagccca gtccttgtct gcagggggag   3240

gcctgagcat ttcccagccc cagtgtccac acctctcaga aaagagaaaa aagaatgtca   3300

gtttaggaga aaagcttcct ttttacttgt gtggttatgt gtggggctgg cacccgaaat   3360

gtgtgacatt cagcttctaa acgatgcctg gagagtctgt ttgctgcaga cacccttgct   3420

cctgagtcat tattttcttt catgttagat tgatgacttc tgtgaataga aatcatcctg   3480

atcctatttt acctggcctc cagggcctgt tgatgggctt tgcaggcagt ccagcagccc   3540

acacctgcag gcaggatgct gtcgtcaatg agctgagggt agctgctttg ctgaagacct   3600

cacacgatgt ccaatctcat ccaaataaca ttgttcccat cctccccacc caccacatca   3660

aaacataaca catcacagca ctcagtagag gtcctgcctc cccatttctc aagggaagcc   3720

agtaggcaac acagccagca cggtgctctc cagggcagcc cctctcagac gaggaggcag   3780

cgggtgcagc caggtgtctg cagagcagcc acaaaggtgg cctaggatgc gggtgtctcc   3840

ccaggtgagt ccatccacac acgtttgaaa aacactatta gtctttctaa cacactgagg   3900

gaaagattaa aatctgtgga ataaaggagg agattttatt tacagatttt tttaaaagcc   3960

acctgggttg acaccttcct acttatccac tagatgtcat cagaggtgct gttccgtggt   4020

tctgcattaa cccctgcctc atgtctgtaa catgtgacag taattccagc tcggtccctc   4080

caggcaaagg agaaacggga cttacttcac aggacagagg attgacagaa gtcagtttaa   4140

gataagtgtt tgaatcagat ttcagtacat ctcattcatt tcttagattt gtattcacaa   4200

ttgtgttctc taaaatgtgt ctaaatttta aaaatatgta catgcataat gtcattttaa   4260

aatctgaagg aaagaatttg aagtccacaa aaagtgtttg aggttctttg gttttgttag   4320

taaaagccag ttctgtggtg atgacctatg gaa                                4353


<210>  1266
<211>  450
<212>  PRT
<213>  Homosapiens

<400>  1266

Met Gly Glu Thr Met Ser Lys Arg Leu Lys Leu His Leu Gly Gly Glu 
1               5                   10                  15      


Ala Glu Met Glu Glu Arg Ala Phe Val Asn Pro Phe Pro Asp Tyr Glu 
            20                  25                  30          


Ala Ala Ala Gly Ala Leu Leu Ala Ser Gly Ala Ala Glu Glu Thr Gly 
        35                  40                  45              


Cys Val Arg Pro Pro Ala Thr Thr Asp Glu Pro Gly Leu Pro Phe His 
    50                  55                  60                  


Gln Asp Gly Lys Ile Ile His Asn Phe Ile Arg Arg Ile Gln Thr Lys 
65                  70                  75                  80  


Ile Lys Asp Leu Leu Gln Gln Met Glu Glu Gly Leu Lys Thr Ala Asp 
                85                  90                  95      


Pro His Asp Cys Ser Ala Tyr Thr Gly Trp Thr Gly Ile Ala Leu Leu 
            100                 105                 110         


Tyr Leu Gln Leu Tyr Arg Val Thr Cys Asp Gln Thr Tyr Leu Leu Arg 
        115                 120                 125             


Ser Leu Asp Tyr Val Lys Arg Thr Leu Arg Asn Leu Asn Gly Arg Arg 
    130                 135                 140                 


Val Thr Phe Leu Cys Gly Asp Ala Gly Pro Leu Ala Val Gly Ala Val 
145                 150                 155                 160 


Ile Tyr His Lys Leu Arg Ser Asp Cys Glu Ser Gln Glu Cys Val Thr 
                165                 170                 175     


Lys Leu Leu Gln Leu Gln Arg Ser Val Val Cys Gln Glu Ser Asp Leu 
            180                 185                 190         


Pro Asp Glu Leu Leu Tyr Gly Arg Ala Gly Tyr Leu Tyr Ala Leu Leu 
        195                 200                 205             


Tyr Leu Asn Thr Glu Ile Gly Pro Gly Thr Val Cys Glu Ser Ala Ile 
    210                 215                 220                 


Lys Glu Val Val Asn Ala Ile Ile Glu Ser Gly Lys Thr Leu Ser Arg 
225                 230                 235                 240 


Glu Glu Arg Lys Thr Glu Arg Cys Pro Leu Leu Tyr Gln Trp His Arg 
                245                 250                 255     


Lys Gln Tyr Val Gly Ala Ala His Gly Met Ala Gly Ile Tyr Tyr Met 
            260                 265                 270         


Leu Met Gln Pro Ala Ala Lys Val Asp Gln Glu Thr Leu Thr Glu Met 
        275                 280                 285             


Val Lys Pro Ser Ile Asp Tyr Val Arg His Lys Lys Phe Arg Ser Gly 
    290                 295                 300                 


Asn Tyr Pro Ser Ser Leu Ser Asn Glu Thr Asp Arg Leu Val His Trp 
305                 310                 315                 320 


Cys His Gly Ala Pro Gly Val Ile His Met Leu Met Gln Ala Tyr Lys 
                325                 330                 335     


Val Phe Lys Glu Glu Lys Tyr Leu Lys Glu Ala Met Glu Cys Ser Asp 
            340                 345                 350         


Val Ile Trp Gln Arg Gly Leu Leu Arg Lys Gly Tyr Gly Ile Cys His 
        355                 360                 365             


Gly Thr Ala Gly Asn Gly Tyr Ser Phe Leu Ser Leu Tyr Arg Leu Thr 
    370                 375                 380                 


Gln Asp Lys Lys Tyr Leu Tyr Arg Ala Cys Lys Phe Ala Glu Trp Cys 
385                 390                 395                 400 


Leu Asp Tyr Gly Ala His Gly Cys Arg Ile Pro Asp Arg Pro Tyr Ser 
                405                 410                 415     


Leu Phe Glu Gly Met Ala Gly Ala Ile His Phe Leu Ser Asp Val Leu 
            420                 425                 430         


Gly Pro Glu Thr Ser Arg Phe Pro Ala Phe Glu Leu Asp Ser Ser Lys 
        435                 440                 445             


Arg Asp 
    450 


<210>  1267
<211>  1495
<212>  DNA
<213>  Homosapiens

<400>  1267
atgacacgag aacaatacat actagcaacc caacagaata acctgccaag gactgagaat     60

gcacaacttt acccagtggg aatttatgga tggcgaaaga ggtgcttata cttctttgtc    120

cttctgctgt tggttaccat gatagttaac ttagccatga caatatggat attgaaagtt    180

atgaatttca ctgtggatgg tatgggaaat ctgagagtca ccaagaaggg aatccgactt    240

gaaggtatat ctgagtttct acttccattg tatgtgaaag aaattcattc tcgaaaggat    300

agtccgctgg tcttacagtc tgacaggaat gtcacagtga atgcaagaaa tcacatgggg    360

cagttaaccg gacagctgac cataggagct gatgctgtgg aagctcagtg taaaagattt    420

gaagtgagag ccagtgaaga tggcagggtg ctgttttctg cagatgaaga tgagattacc    480

attggggctg aaaagctgaa agttacaggc actgaaggag ccgtatttgg gcactctgtg    540

gagacgccgc acatcagagc agagccatcc caagatctca ggcttgaatc acccaccaga    600

tccttgatca tggaagctcc ccgtggggtc caggtgagtg ctgctgcagg agacttcaag    660

gccacctgca ggaaggagct ccatctgcaa tctacagaag gggagatatt tttaaatgca    720

gagacaatca agctgggaaa tctaccaact ggctccttct catcttcttc acccagctcc    780

tcaagttctc gacagacagt gtatgaactc tgcgtctgcc ccaatggcaa actttacctt    840

tctccagcag gagtaggttc cacttgtcag tccagtagca acatctgcct gtggagctga    900

agtgactgat ttctcctcac accagaatag ccttttgttc ctgtccgtct gcttcacagt    960

tctgctcggt ttcccttgtg atcagtccag agcttcttcg aatggtccac agagcaactt   1020

ccagtgtgag cagggattcg ccaccacctt ctcttgtgat ttactgtact gctcaacaca   1080

gagggtgtga ttgacacagc agtggaaaaa gcgtcgtcag caggaaaact ggatcatgac   1140

ttttgctcga aagggagaat aacataggtg cctttgctac gcgaagtgaa gcacacagtt   1200

ttagattttt gcaggacctg gatatgaact gcacatatat acattacata aatgaaattc   1260

ccagtatcca atggcaagat gaaatggtta accctgtaag aaaacttatt ctacattctg   1320

aaagcacaat tttccattca tctttttgga tgtaaacttt tatccccgac ttttaaaatt   1380

ttaaagcatt atgtaatgct tgctttacta aaatttaaat tcaatacatg gtttttaaca   1440

aaacagaaca aaacaaaaca atacagaatc tctccctgaa aaaaaaaaaa aaaaa        1495


<210>  1268
<211>  299
<212>  PRT
<213>  Homosapiens

<400>  1268

Met Thr Arg Glu Gln Tyr Ile Leu Ala Thr Gln Gln Asn Asn Leu Pro 
1               5                   10                  15      


Arg Thr Glu Asn Ala Gln Leu Tyr Pro Val Gly Ile Tyr Gly Trp Arg 
            20                  25                  30          


Lys Arg Cys Leu Tyr Phe Phe Val Leu Leu Leu Leu Val Thr Met Ile 
        35                  40                  45              


Val Asn Leu Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr 
    50                  55                  60                  


Val Asp Gly Met Gly Asn Leu Arg Val Thr Lys Lys Gly Ile Arg Leu 
65                  70                  75                  80  


Glu Gly Ile Ser Glu Phe Leu Leu Pro Leu Tyr Val Lys Glu Ile His 
                85                  90                  95      


Ser Arg Lys Asp Ser Pro Leu Val Leu Gln Ser Asp Arg Asn Val Thr 
            100                 105                 110         


Val Asn Ala Arg Asn His Met Gly Gln Leu Thr Gly Gln Leu Thr Ile 
        115                 120                 125             


Gly Ala Asp Ala Val Glu Ala Gln Cys Lys Arg Phe Glu Val Arg Ala 
    130                 135                 140                 


Ser Glu Asp Gly Arg Val Leu Phe Ser Ala Asp Glu Asp Glu Ile Thr 
145                 150                 155                 160 


Ile Gly Ala Glu Lys Leu Lys Val Thr Gly Thr Glu Gly Ala Val Phe 
                165                 170                 175     


Gly His Ser Val Glu Thr Pro His Ile Arg Ala Glu Pro Ser Gln Asp 
            180                 185                 190         


Leu Arg Leu Glu Ser Pro Thr Arg Ser Leu Ile Met Glu Ala Pro Arg 
        195                 200                 205             


Gly Val Gln Val Ser Ala Ala Ala Gly Asp Phe Lys Ala Thr Cys Arg 
    210                 215                 220                 


Lys Glu Leu His Leu Gln Ser Thr Glu Gly Glu Ile Phe Leu Asn Ala 
225                 230                 235                 240 


Glu Thr Ile Lys Leu Gly Asn Leu Pro Thr Gly Ser Phe Ser Ser Ser 
                245                 250                 255     


Ser Pro Ser Ser Ser Ser Ser Arg Gln Thr Val Tyr Glu Leu Cys Val 
            260                 265                 270         


Cys Pro Asn Gly Lys Leu Tyr Leu Ser Pro Ala Gly Val Gly Ser Thr 
        275                 280                 285             


Cys Gln Ser Ser Ser Asn Ile Cys Leu Trp Ser 
    290                 295                 


<210>  1269
<211>  3740
<212>  DNA
<213>  Homosapiens

<400>  1269
aggaagcctc aagacgcgga gcagcggcag gaaggagccc ccggcagccc ggaggagcat     60

gggcaccttg cgggatttac agtacgcgct ccaggagaag atcgaggagc tgaggcagcg    120

ggatgctctc atcgacgagc tggagctgga gttggatcag aaggacgaac tgatccagaa    180

gctgcagaac gagctggaca agtaccgctc ggtgatccga ccagccaccc agcaggcgca    240

gaagcagagc gcgagcacct tgcagggcga gccgcgcacc aagcggcagg cgatctccgc    300

cgagcccacc gccttcgaca tccaggatct cagccatgtg accctgccct tctaccccaa    360

gagcccacag tccaaggatc ttataaagga agctatcctt gacaatgact ttatgaagaa    420

cttggagctg tcgcagatcc aggagattgt ggattgtatg tacccggtgg agtatggcaa    480

ggacagttgc atcatcaaag aaggagacgt ggggtcactg gtgtatgtca tggaagatgg    540

taaggttgaa gttacaaaag aaggtgtgaa gttgtgtacc atgggtccag gaaaagtgtt    600

tggggaattg gctattcttt acaactgtac ccggacagcg accgtcaaga ctcttgtaaa    660

tgtaaaactc tgggccattg atcgacaatg ttttcaaaca ataatgatga ggacaggact    720

catcaagcat accgagtata tggaattttt aaaaagcgtt ccaacattcc agagccttcc    780

tgaagagatc ctcagcaagc ttgctgatgt ccttgaagag acccactatg aaaatggaga    840

atatattatc aggcaaggtg caagagggga caccttcttt atcatcagca aaggaacggt    900

aaatgtcact cgtgaagact caccgagtga agacccagtc tttcttagaa ctttaggaaa    960

aggagactgg tttggagaga aagccttgca gggggaagat gtgagaacag caaacgtaat   1020

tgctgcagaa gctgtaacct gccttgtgat tgacagagac tcttttaaac atttgattgg   1080

agggctggat gatgtttcta ataaagcata tgaagatgca gaagctaaag caaaatatga   1140

agctgaagcg gctttcttcg ccaacctgaa gctgtctgat ttcaacatca ttgataccct   1200

tggagttgga ggtttcggac gagtagaact ggtccagttg aaaagtgaag aatccaaaac   1260

gtttgcaatg aagattctca agaaacgtca cattgtggac acaagacagc aggagcacat   1320

ccgctcagag aagcagatca tgcagggggc tcattccgat ttcatagtga gactgtacag   1380

aacatttaag gacagcaaat atttgtatat gttgatggaa gcttgtctag gtggagagct   1440

ctggaccatt ctcagggata gaggttcgtt tgaagattct acaaccagat tttacacagc   1500

atgtgtggta gaagcttttg cctatctgca ttccaaagga atcatttaca gggacctcaa   1560

gccagaaaat ctcatcctag atcaccgagg ttatgccaaa ctggttgatt ttggctttgc   1620

aaagaaaata ggatttggaa agaaaacatg gactttttgt gggactccag agtatgtagc   1680

cccagagatc atcctgaaca aaggccatga catttcagcc gactactggt cactgggaat   1740

cctaatgtat gaactcctga ctggcagccc acctttctca ggcccagatc ctatgaaaac   1800

ctataacatc atattgaggg ggattgacat gatagaattt ccaaagaaga ttgccaaaaa   1860

tgctgctaat ttaattaaaa aactatgcag ggacaatcca tcagaaagat tagggaattt   1920

gaaaaatgga gtaaaagaca ttcaaaagca caaatggttt gagggcttta actgggaagg   1980

cttaagaaaa ggtaccttga cacctcctat aataccaagt gttgcatcac ccacagacac   2040

aagtaatttt gacagtttcc ctgaggacaa cgatgaacca ccacctgatg acaactcagg   2100

atgggatata gacttctaat gtatttctct tacctgcttc tgccttgctg aagacagctt   2160

tttctgagac acagctgcca gcaaacctga gggaaagaga gaagattagt gctcggggtc   2220

accatgatgc ctttgatcga tgctgctcca gtaactacag tggcattagg acttatcgct   2280

tagatgacaa tagtgctctt tacatgtttt ctgtttgaac ctaaaatagc agttgacatg   2340

gtggtcctga agcaaagcct ttcaccagta aagagatgtt ttctattgtt gcaatgacct   2400

tgctttgctc tgattataat ttgaaagact gtaggaaaca cttcaatgta gtataagagt   2460

ctgtaccttg ctggaatatt caagaagatg aaagaataat atattgggta caatagatta   2520

ctatggtaca gaaactgggc tattcccttt cttcaagtga aggctgtggg atctattaca   2580

gctgcaggcc ggtgtatata ccatacaaaa gaggaccaca catctgttgg tcacagagtt   2640

catgtcacac cagtgctaga agtttcatga ttttatttcc cagcagtgct gatgacaaga   2700

ctgaatgtta ccttttcttt ctgacagatt ttaaaaattg atatgataaa agcacaactg   2760

ctatagattc tgctgagacc tctcatagta ggtatatatg agttttcaca gaagactgaa   2820

aaataatgca tgatatttgt ttgttttttt tgataaattg gcatgacaga gtggggaaaa   2880

aaagcaattc acaaaaccat ttcatatttt ttaaaatatt gtgcttaaag atggtcctgg   2940

aagtaaatga ctagcagcca attggtttta cttaacatac cctcaaactg aggcttaaag   3000

tattcccttt tataaaaata aatgcttggg gtagggtgga gtggggaggg attaaaaccc   3060

atccaaaaaa taaataaaaa ctatataggt gctatgtata tctttcatct gtaaatgtca   3120

gtgtctgaac agcaacacaa attcaaatca ttatacgtgt agccagaaac tcaagcattt   3180

tcactaaagt tattaaacca aactcctgtc caatttgact tatacaacat agtcagtcta   3240

gagttgagag acaaaggtaa ttataaacct atttgaacta gcttcttgtc ttaggcctga   3300

accaaaaaac aacaaacaaa caaaaaacaa gaatgaaaaa cagaaataaa agaagtagaa   3360

aagacaaaga aagaaagccc aaagtcaaag ttgttaatat ttacaggttt accagatctg   3420

gaacattact tatttgaggt cagagaacaa aacaagaacc tggccaggtg ttgattacct   3480

tttagtgaat aagctgagtc catatacttg tctaactaag aaagcagtac agaggaaaac   3540

aggaacctga tttttttaaa ataaatttta aataaaatag aattactaca attctgcaat   3600

ttcatactac ctaaaaaaga ctagatttga aaatgtcaag ctgatttact ttattcacat   3660

ggagaaaaga atccacaaat taaactgagt ccttcactgg catgccagtt gactattatt   3720

agctgtcata agtaaccccg                                               3740


<210>  1270
<211>  686
<212>  PRT
<213>  Homosapiens

<400>  1270

Met Gly Thr Leu Arg Asp Leu Gln Tyr Ala Leu Gln Glu Lys Ile Glu 
1               5                   10                  15      


Glu Leu Arg Gln Arg Asp Ala Leu Ile Asp Glu Leu Glu Leu Glu Leu 
            20                  25                  30          


Asp Gln Lys Asp Glu Leu Ile Gln Lys Leu Gln Asn Glu Leu Asp Lys 
        35                  40                  45              


Tyr Arg Ser Val Ile Arg Pro Ala Thr Gln Gln Ala Gln Lys Gln Ser 
    50                  55                  60                  


Ala Ser Thr Leu Gln Gly Glu Pro Arg Thr Lys Arg Gln Ala Ile Ser 
65                  70                  75                  80  


Ala Glu Pro Thr Ala Phe Asp Ile Gln Asp Leu Ser His Val Thr Leu 
                85                  90                  95      


Pro Phe Tyr Pro Lys Ser Pro Gln Ser Lys Asp Leu Ile Lys Glu Ala 
            100                 105                 110         


Ile Leu Asp Asn Asp Phe Met Lys Asn Leu Glu Leu Ser Gln Ile Gln 
        115                 120                 125             


Glu Ile Val Asp Cys Met Tyr Pro Val Glu Tyr Gly Lys Asp Ser Cys 
    130                 135                 140                 


Ile Ile Lys Glu Gly Asp Val Gly Ser Leu Val Tyr Val Met Glu Asp 
145                 150                 155                 160 


Gly Lys Val Glu Val Thr Lys Glu Gly Val Lys Leu Cys Thr Met Gly 
                165                 170                 175     


Pro Gly Lys Val Phe Gly Glu Leu Ala Ile Leu Tyr Asn Cys Thr Arg 
            180                 185                 190         


Thr Ala Thr Val Lys Thr Leu Val Asn Val Lys Leu Trp Ala Ile Asp 
        195                 200                 205             


Arg Gln Cys Phe Gln Thr Ile Met Met Arg Thr Gly Leu Ile Lys His 
    210                 215                 220                 


Thr Glu Tyr Met Glu Phe Leu Lys Ser Val Pro Thr Phe Gln Ser Leu 
225                 230                 235                 240 


Pro Glu Glu Ile Leu Ser Lys Leu Ala Asp Val Leu Glu Glu Thr His 
                245                 250                 255     


Tyr Glu Asn Gly Glu Tyr Ile Ile Arg Gln Gly Ala Arg Gly Asp Thr 
            260                 265                 270         


Phe Phe Ile Ile Ser Lys Gly Thr Val Asn Val Thr Arg Glu Asp Ser 
        275                 280                 285             


Pro Ser Glu Asp Pro Val Phe Leu Arg Thr Leu Gly Lys Gly Asp Trp 
    290                 295                 300                 


Phe Gly Glu Lys Ala Leu Gln Gly Glu Asp Val Arg Thr Ala Asn Val 
305                 310                 315                 320 


Ile Ala Ala Glu Ala Val Thr Cys Leu Val Ile Asp Arg Asp Ser Phe 
                325                 330                 335     


Lys His Leu Ile Gly Gly Leu Asp Asp Val Ser Asn Lys Ala Tyr Glu 
            340                 345                 350         


Asp Ala Glu Ala Lys Ala Lys Tyr Glu Ala Glu Ala Ala Phe Phe Ala 
        355                 360                 365             


Asn Leu Lys Leu Ser Asp Phe Asn Ile Ile Asp Thr Leu Gly Val Gly 
    370                 375                 380                 


Gly Phe Gly Arg Val Glu Leu Val Gln Leu Lys Ser Glu Glu Ser Lys 
385                 390                 395                 400 


Thr Phe Ala Met Lys Ile Leu Lys Lys Arg His Ile Val Asp Thr Arg 
                405                 410                 415     


Gln Gln Glu His Ile Arg Ser Glu Lys Gln Ile Met Gln Gly Ala His 
            420                 425                 430         


Ser Asp Phe Ile Val Arg Leu Tyr Arg Thr Phe Lys Asp Ser Lys Tyr 
        435                 440                 445             


Leu Tyr Met Leu Met Glu Ala Cys Leu Gly Gly Glu Leu Trp Thr Ile 
    450                 455                 460                 


Leu Arg Asp Arg Gly Ser Phe Glu Asp Ser Thr Thr Arg Phe Tyr Thr 
465                 470                 475                 480 


Ala Cys Val Val Glu Ala Phe Ala Tyr Leu His Ser Lys Gly Ile Ile 
                485                 490                 495     


Tyr Arg Asp Leu Lys Pro Glu Asn Leu Ile Leu Asp His Arg Gly Tyr 
            500                 505                 510         


Ala Lys Leu Val Asp Phe Gly Phe Ala Lys Lys Ile Gly Phe Gly Lys 
        515                 520                 525             


Lys Thr Trp Thr Phe Cys Gly Thr Pro Glu Tyr Val Ala Pro Glu Ile 
    530                 535                 540                 


Ile Leu Asn Lys Gly His Asp Ile Ser Ala Asp Tyr Trp Ser Leu Gly 
545                 550                 555                 560 


Ile Leu Met Tyr Glu Leu Leu Thr Gly Ser Pro Pro Phe Ser Gly Pro 
                565                 570                 575     


Asp Pro Met Lys Thr Tyr Asn Ile Ile Leu Arg Gly Ile Asp Met Ile 
            580                 585                 590         


Glu Phe Pro Lys Lys Ile Ala Lys Asn Ala Ala Asn Leu Ile Lys Lys 
        595                 600                 605             


Leu Cys Arg Asp Asn Pro Ser Glu Arg Leu Gly Asn Leu Lys Asn Gly 
    610                 615                 620                 


Val Lys Asp Ile Gln Lys His Lys Trp Phe Glu Gly Phe Asn Trp Glu 
625                 630                 635                 640 


Gly Leu Arg Lys Gly Thr Leu Thr Pro Pro Ile Ile Pro Ser Val Ala 
                645                 650                 655     


Ser Pro Thr Asp Thr Ser Asn Phe Asp Ser Phe Pro Glu Asp Asn Asp 
            660                 665                 670         


Glu Pro Pro Pro Asp Asp Asn Ser Gly Trp Asp Ile Asp Phe 
        675                 680                 685     


<210>  1271
<211>  4127
<212>  DNA
<213>  Homosapiens

<400>  1271
agacgcctcg aagaatccgc tatcggctgt ctgcacaacc ggaatcatgt cgagtttggc     60

ggtgagagac ccggcaatgg atcgatcact gcgttccgtg ttcgtgggga acattccata    120

tgaggcaact gaggagcagt taaaggacat tttctcggag gttggttctg ttgtcagttt    180

ccggctggta tacgatagag agacgggaaa acccaagggc tatggcttct gcgaatacca    240

agaccaggag accgcgctta gtgccatgcg gaacctcaat gggcgggagt tcagtgggag    300

agcgcttcgg gtggacaatg ctgccagtga aaagaataag gaggagttaa agagccttgg    360

gcctgcagcg cccattattg actcacccta tggggatccc atcgatccag aagatgcccc    420

tgaatcgatt accagagcag tagccagtct ccccccggag cagatgtttg agctgatgaa    480

gcagatgaag ctctgtgtcc aaaacagcca ccaggaagct cgaaacatgt tacttcaaaa    540

tccacaactg gcttatgcac tgttgcaggc acaagtagtg atgagaatca tggatccaga    600

gattgctctg aaaattctgc atcggaagat acatgtcaca ccactgatcc caggcaaatc    660

tcagtctgtg tctgtctctg gccctggccc tggccctggc cctgggctct gcccaggacc    720

taatgttctg ctgaaccagc agaatcctcc agctcctcag cctcagcatt tggctagaag    780

acctgtgaag gacattcctc ctctgatgca gactcctatc cagggtggaa ttccagctcc    840

agggccaata ccagctgcag ttcccggagc tggtcctggt tccttaactc ctggaggagc    900

aatgcagccc caacttggaa tgccaggggt tggcccagtg cctttagagc ggggacaagt    960

gcagatgtca gatcctagag ctcctatacc tcgcggaccc gtgactcctg gtggtctgcc   1020

tcctcgagga ctgttaggag atgctccaaa tgacccacgt ggagggactt tgctttcagt   1080

cactggagaa gtggagccca gaggttatct gggtccaccc catcagggtc cccccatgca   1140

tcatgcctct ggtcatgaca ctcgtggccc ttcctcacat gagatgaggg gagggccatt   1200

aggagatccc agactgctaa ttggagagcc cagaggcccc atgatagatc aaaggggtct   1260

acctatggat ggtagaggtg gtagagattc tcgagcgatg gagactcgtg ccatggaaac   1320

tgaggtctta gagacacgtg taatggagag gagaggaatg gagacctgtg cgatggaaac   1380

cagagggatg gaagcaaggg gcatggatgc aagaggattg gagatgaggg gccctgtccc   1440

cagttcaaga ggccctatga ctggtggaat tcagggtcct ggtcccatta atataggggc   1500

aggtggccct cctcagggac ccagacaggt cccaggcatt tcaggggtgg ggaatcctgg   1560

agctggtatg cagggtacag gcatacaagg aacaggcatg cagggagcag gcatacaagg   1620

aggagggatg cagggggcag gcatacaagg agtcagtata caaggaggag gtatacaagg   1680

aggaggtata cagggggcaa gcaagcaagg tggaagccag cctagcagtt ttagtcctgg   1740

gcagagccag gtcactccac aggatcagga gaaggcagct ttgatcatgc aggttcttca   1800

actgactgca gatcagattg ccatgctgcc ccctgagcaa aggcagagta tcctgatttt   1860

aaaggaacaa atccagaaat ccactggagc gtcttgaaag gttttagaaa atatttggct   1920

gtagtctcaa attttattct gtagcatgga gaatgggtgc aaaaagctga cttctgtatc   1980

cccacacttg gattagggtt tccctcctcc tagaacctaa tcttattttt tgttcttttt   2040

ctttctttct gttttccttt tttttttaat tgagggtggg gggaggaggg agtgcgtctg   2100

ttcactttaa gttactttaa aataactctg aacatgatta tattatgcca aataagatta   2160

caaagaataa gcagcaatat tgaagcatct acagtatgtt aactacattt tttaaatgtc   2220

gagtaaaact tcgtgaaaac tgctcataaa gactaaaagt tgacctgtta aaacgttaat   2280

gtactaagat agttttaaga tttttggttg tataacaaaa taaaagttta cccaaaagta   2340

taagatacat tttttggtaa accatttaaa atacaaaatc ctattttgga ggcaatagga   2400

taagcattgt cttagtgttt tagaattatt tttgaaacag agttaacagg ataaggttac   2460

acttgtatta gaattgtttt tttctaaagt tatgttacct gaaaaatcaa ggagtgcacc   2520

tgatttactg ttgcttcatt tatcccatcc ttcagagacc agcaaggttc tgccaggccc   2580

caagcatctg agcatgatga ttttgctgtg acaattctaa gatcaaccag gttacttaag   2640

tccgctctga tgaaacccag tctctcaata ccttcctatt tctcaatagt ctttaagccc   2700

taaatctgag tcagtaattc tctaaaaatc cttcccaaaa atcagtgtct agggactggt   2760

tgatctagat gagttataaa tggtatttga cttttcataa gtagtggaag gtttcactaa   2820

gtaaagatct gagtttcttg gtatctgacg tttgtataca gatggtgtcc atttgctcaa   2880

ccagacagga gttaacttgt attagaattg ttttttctaa agttatgtta cctgagaaat   2940

taaggactgc acctggttta atgttgcttc acttatccca ccctacagag accagcaagg   3000

ttctgccagg cctcgagcat ccaagcatga ttttgctgtg acaaatctaa aatcaaccag   3060

gctacttaag tctgctctga tgaaacccaa taatctctca ataccttcct atttctcaat   3120

agtctttaaa ccctaaatct gagtcagtaa ttctcttaca tccttcccaa aaatcagtgt   3180

ctagggacta gttgatctgg atgagttata catgatattt gacttttcat aagtagtgga   3240

aggtttcact aagtaaaact ctcagtttct tggtatctgg ctttcttata cagatggtgt   3300

ccatttgctc caccagacag gagttaaaaa cctttaaaga gcatttaaca tgccttttag   3360

ttttcttatt tcataatcta cttttctatc attaatcatc ttaccaggaa taatcaaggc   3420

ccaggtaggt agaagttttt atatagcctg aatactcact tgacttactg ctcattttac   3480

tttttgcatg gaatacagcc atttagtcct aatatacata ccaatgagac aattaaaaat   3540

tggttggaag atggagctta tcacattgtg ctactacgac tttatttttt cttgaaaata   3600

aagccttgag gatgtgaaca taaatgttgg tatcataaaa caagtagtaa taaaagcata   3660

aattatcaaa tatcaggtga tcttactatg gagaagaaaa accaatatct agttacagat   3720

gaaaaaatgt ttaatacaaa gagctgaaaa tgtagaaatt gagttatctt ccctttgcaa   3780

aatttttaca ctttaaatta gtaattcttt gtttgcaagg ttttcatccc tatgctgttg   3840

ttttctacta cctgttttac tcttgttcat actgctactt tcccatgttt cctatatgcc   3900

tcccctatat tggagaggat aactcgcgtt tacatatgtg atagttatgc ttaatactaa   3960

ttcacagagt tggctcgatc attttgagat tctagttgct ttatctcaaa gctttcactg   4020

aagggctgta actgaaaatt attaaatgtt agtctttagt caaatctctg cattgtttca   4080

tgcagaaaat aaagatacaa ttaaggctga aaaaaaaaaa aaaaaaa                 4127


<210>  1272
<211>  616
<212>  PRT
<213>  Homosapiens

<400>  1272

Met Ser Ser Leu Ala Val Arg Asp Pro Ala Met Asp Arg Ser Leu Arg 
1               5                   10                  15      


Ser Val Phe Val Gly Asn Ile Pro Tyr Glu Ala Thr Glu Glu Gln Leu 
            20                  25                  30          


Lys Asp Ile Phe Ser Glu Val Gly Ser Val Val Ser Phe Arg Leu Val 
        35                  40                  45              


Tyr Asp Arg Glu Thr Gly Lys Pro Lys Gly Tyr Gly Phe Cys Glu Tyr 
    50                  55                  60                  


Gln Asp Gln Glu Thr Ala Leu Ser Ala Met Arg Asn Leu Asn Gly Arg 
65                  70                  75                  80  


Glu Phe Ser Gly Arg Ala Leu Arg Val Asp Asn Ala Ala Ser Glu Lys 
                85                  90                  95      


Asn Lys Glu Glu Leu Lys Ser Leu Gly Pro Ala Ala Pro Ile Ile Asp 
            100                 105                 110         


Ser Pro Tyr Gly Asp Pro Ile Asp Pro Glu Asp Ala Pro Glu Ser Ile 
        115                 120                 125             


Thr Arg Ala Val Ala Ser Leu Pro Pro Glu Gln Met Phe Glu Leu Met 
    130                 135                 140                 


Lys Gln Met Lys Leu Cys Val Gln Asn Ser His Gln Glu Ala Arg Asn 
145                 150                 155                 160 


Met Leu Leu Gln Asn Pro Gln Leu Ala Tyr Ala Leu Leu Gln Ala Gln 
                165                 170                 175     


Val Val Met Arg Ile Met Asp Pro Glu Ile Ala Leu Lys Ile Leu His 
            180                 185                 190         


Arg Lys Ile His Val Thr Pro Leu Ile Pro Gly Lys Ser Gln Ser Val 
        195                 200                 205             


Ser Val Ser Gly Pro Gly Pro Gly Pro Gly Pro Gly Leu Cys Pro Gly 
    210                 215                 220                 


Pro Asn Val Leu Leu Asn Gln Gln Asn Pro Pro Ala Pro Gln Pro Gln 
225                 230                 235                 240 


His Leu Ala Arg Arg Pro Val Lys Asp Ile Pro Pro Leu Met Gln Thr 
                245                 250                 255     


Pro Ile Gln Gly Gly Ile Pro Ala Pro Gly Pro Ile Pro Ala Ala Val 
            260                 265                 270         


Pro Gly Ala Gly Pro Gly Ser Leu Thr Pro Gly Gly Ala Met Gln Pro 
        275                 280                 285             


Gln Leu Gly Met Pro Gly Val Gly Pro Val Pro Leu Glu Arg Gly Gln 
    290                 295                 300                 


Val Gln Met Ser Asp Pro Arg Ala Pro Ile Pro Arg Gly Pro Val Thr 
305                 310                 315                 320 


Pro Gly Gly Leu Pro Pro Arg Gly Leu Leu Gly Asp Ala Pro Asn Asp 
                325                 330                 335     


Pro Arg Gly Gly Thr Leu Leu Ser Val Thr Gly Glu Val Glu Pro Arg 
            340                 345                 350         


Gly Tyr Leu Gly Pro Pro His Gln Gly Pro Pro Met His His Ala Ser 
        355                 360                 365             


Gly His Asp Thr Arg Gly Pro Ser Ser His Glu Met Arg Gly Gly Pro 
    370                 375                 380                 


Leu Gly Asp Pro Arg Leu Leu Ile Gly Glu Pro Arg Gly Pro Met Ile 
385                 390                 395                 400 


Asp Gln Arg Gly Leu Pro Met Asp Gly Arg Gly Gly Arg Asp Ser Arg 
                405                 410                 415     


Ala Met Glu Thr Arg Ala Met Glu Thr Glu Val Leu Glu Thr Arg Val 
            420                 425                 430         


Met Glu Arg Arg Gly Met Glu Thr Cys Ala Met Glu Thr Arg Gly Met 
        435                 440                 445             


Glu Ala Arg Gly Met Asp Ala Arg Gly Leu Glu Met Arg Gly Pro Val 
    450                 455                 460                 


Pro Ser Ser Arg Gly Pro Met Thr Gly Gly Ile Gln Gly Pro Gly Pro 
465                 470                 475                 480 


Ile Asn Ile Gly Ala Gly Gly Pro Pro Gln Gly Pro Arg Gln Val Pro 
                485                 490                 495     


Gly Ile Ser Gly Val Gly Asn Pro Gly Ala Gly Met Gln Gly Thr Gly 
            500                 505                 510         


Ile Gln Gly Thr Gly Met Gln Gly Ala Gly Ile Gln Gly Gly Gly Met 
        515                 520                 525             


Gln Gly Ala Gly Ile Gln Gly Val Ser Ile Gln Gly Gly Gly Ile Gln 
    530                 535                 540                 


Gly Gly Gly Ile Gln Gly Ala Ser Lys Gln Gly Gly Ser Gln Pro Ser 
545                 550                 555                 560 


Ser Phe Ser Pro Gly Gln Ser Gln Val Thr Pro Gln Asp Gln Glu Lys 
                565                 570                 575     


Ala Ala Leu Ile Met Gln Val Leu Gln Leu Thr Ala Asp Gln Ile Ala 
            580                 585                 590         


Met Leu Pro Pro Glu Gln Arg Gln Ser Ile Leu Ile Leu Lys Glu Gln 
        595                 600                 605             


Ile Gln Lys Ser Thr Gly Ala Ser 
    610                 615     


<210>  1273
<211>  1166
<212>  DNA
<213>  Homosapiens

<400>  1273
tcgggtatga ggctgggact aagccaaggg attcaggtgt ggtgccggtg ggaactgagg     60

aagcgcccaa ggaaatgaaa cacgatttcc aaaatgaact taatctttca tgagaaactg    120

aggatagaga tgtcaataag cagccactgt ttccacctcc ccacctgaag agctaggagg    180

acaactacaa agagcctgac tgccttctcg gaatgaggag agaggaaaac agcaacagta    240

tcagttttca agatggcagc atctatgcat ggtcagccca gtccttctct agaagatgca    300

aaactcagaa gaccaatggt catagaaatc atagaaaaaa attttgacta tcttagaaaa    360

gaaatgacac aaaatatata tcaaatggcg acatttggaa caacagctgg tttctctgga    420

atattctcaa acttcctgtt cagacgctgc ttcaaggtta aacatgatgc tttgaagaca    480

tatgcatcat tggctacact tccatttttg tctactgttg ttactgacaa gctttttgta    540

attgatgctt tgtattcaga taatataagc aaggaaaact gtgttttcag aagctcactg    600

attggcatag tttgtggtgt tttctatccc agttctttgg cttttactaa aaatggacgc    660

ctggcaacca agtatcatac cgttccactg ccaccaaaag gaagggtttt aatccattgg    720

atgacgcttt gtcaaacaca aatgaaatta atggcgattc ctctagtctt tcagattatg    780

tttggaatat taaatggtct ataccattat gcagtatttg aagagacact tgagaaaact    840

atacatgaag agtaaccaaa aaaatgaatg gttgctaact tagcaaaatg aagtttctat    900

aaagaggact caggcattgc tgaaagagtt aaaagtaact gtgaacaaat aatttgttct    960

gtgccttttg cctggtatat agcaaatact caaaaaatat tcaataattc aatcaataaa   1020

tataagtttc atcttacacg taagatacag gtcttatctc ctgatggtgt gtccattttg   1080

cctggtatat aacagataat aaatatccag tgtcaataaa aaaaaaaaaa aaaaaaaaaa   1140

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1166


<210>  1274
<211>  200
<212>  PRT
<213>  Homosapiens

<400>  1274

Met Ala Ala Ser Met His Gly Gln Pro Ser Pro Ser Leu Glu Asp Ala 
1               5                   10                  15      


Lys Leu Arg Arg Pro Met Val Ile Glu Ile Ile Glu Lys Asn Phe Asp 
            20                  25                  30          


Tyr Leu Arg Lys Glu Met Thr Gln Asn Ile Tyr Gln Met Ala Thr Phe 
        35                  40                  45              


Gly Thr Thr Ala Gly Phe Ser Gly Ile Phe Ser Asn Phe Leu Phe Arg 
    50                  55                  60                  


Arg Cys Phe Lys Val Lys His Asp Ala Leu Lys Thr Tyr Ala Ser Leu 
65                  70                  75                  80  


Ala Thr Leu Pro Phe Leu Ser Thr Val Val Thr Asp Lys Leu Phe Val 
                85                  90                  95      


Ile Asp Ala Leu Tyr Ser Asp Asn Ile Ser Lys Glu Asn Cys Val Phe 
            100                 105                 110         


Arg Ser Ser Leu Ile Gly Ile Val Cys Gly Val Phe Tyr Pro Ser Ser 
        115                 120                 125             


Leu Ala Phe Thr Lys Asn Gly Arg Leu Ala Thr Lys Tyr His Thr Val 
    130                 135                 140                 


Pro Leu Pro Pro Lys Gly Arg Val Leu Ile His Trp Met Thr Leu Cys 
145                 150                 155                 160 


Gln Thr Gln Met Lys Leu Met Ala Ile Pro Leu Val Phe Gln Ile Met 
                165                 170                 175     


Phe Gly Ile Leu Asn Gly Leu Tyr His Tyr Ala Val Phe Glu Glu Thr 
            180                 185                 190         


Leu Glu Lys Thr Ile His Glu Glu 
        195                 200 


<210>  1275
<211>  773
<212>  DNA
<213>  Homosapiens

<400>  1275
cccaggtaat ttgagcaaag gccacagtga actccggcgt ggctgaggaa ggaggaggca     60

cccacaggct gctgggagga gagcataagg ctcaaaatgg aaaatcataa atccaataat    120

aaggaaaaca taacaattgt tgatatatcc agaaaaatta accagcttcc agaagcagaa    180

aggaatctac ttgaaaatgg atcggtttat gttggattaa atgctgctct ttgtggcctc    240

atagcaaaca gtctttttcg acgcatcttg aatgtgacaa aggctcgcat agctgctggc    300

ttaccaatgg cagggatacc ttttcttaca acagacttaa cttacagatg ttttgtaagt    360

tttcctttga atacaggtga tttggattgt gaaacctgta ccataacacg gagtggactg    420

actggtcttg ttattggtgg tctataccct gttttcttgg ctatacctgt aaatggtggt    480

ctagcagcca ggtatcaatc agctctgtta ccacacaaag ggaacatctt aagttactgg    540

attagaactt ctaagcctgt ctttagaaag atgttatttc ctattttgct ccagactatg    600

ttttcagcat accttgggtc tgaacaatat aaactactta taaaggccct tcagttatct    660

gaacctggca aagaaattca ctgattttaa acaaatatgt aaacaaaaat aaaatggtaa    720

aaacagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa           773


<210>  1276
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  1276

Met Glu Asn His Lys Ser Asn Asn Lys Glu Asn Ile Thr Ile Val Asp 
1               5                   10                  15      


Ile Ser Arg Lys Ile Asn Gln Leu Pro Glu Ala Glu Arg Asn Leu Leu 
            20                  25                  30          


Glu Asn Gly Ser Val Tyr Val Gly Leu Asn Ala Ala Leu Cys Gly Leu 
        35                  40                  45              


Ile Ala Asn Ser Leu Phe Arg Arg Ile Leu Asn Val Thr Lys Ala Arg 
    50                  55                  60                  


Ile Ala Ala Gly Leu Pro Met Ala Gly Ile Pro Phe Leu Thr Thr Asp 
65                  70                  75                  80  


Leu Thr Tyr Arg Cys Phe Val Ser Phe Pro Leu Asn Thr Gly Asp Leu 
                85                  90                  95      


Asp Cys Glu Thr Cys Thr Ile Thr Arg Ser Gly Leu Thr Gly Leu Val 
            100                 105                 110         


Ile Gly Gly Leu Tyr Pro Val Phe Leu Ala Ile Pro Val Asn Gly Gly 
        115                 120                 125             


Leu Ala Ala Arg Tyr Gln Ser Ala Leu Leu Pro His Lys Gly Asn Ile 
    130                 135                 140                 


Leu Ser Tyr Trp Ile Arg Thr Ser Lys Pro Val Phe Arg Lys Met Leu 
145                 150                 155                 160 


Phe Pro Ile Leu Leu Gln Thr Met Phe Ser Ala Tyr Leu Gly Ser Glu 
                165                 170                 175     


Gln Tyr Lys Leu Leu Ile Lys Ala Leu Gln Leu Ser Glu Pro Gly Lys 
            180                 185                 190         


Glu Ile His 
        195 


<210>  1277
<211>  2952
<212>  DNA
<213>  Homosapiens

<400>  1277
ggcgcggtcg agtcatcgca gggcctcacc gcttcgttct cccgtccctc cccgcgcctt     60

ggctcgacta gccaagtgag gcgggaggcg actcggacct ttccctgcat ttcgtttcgg    120

ccagtgccgg ggctacccgc cctggggcct gggatccttg gggcccgtga gccactctta    180

gcggccgggg ctaccgcggc ccgccgtggc cctcatgagg catagctgac caagctgctg    240

gcagcctcgg gcagcaactc cccaacccgc agtgagagcc cggagccggc tgcaacttgt    300

tcgctgccct ctgacctgac ccgggctgca gcgggggagg aggagacggc ggcggcgatc    360

tcccggccgc aagcagcagt ttggcgacga aggagagttg gaagccggga gggggagccg    420

cggcggcgtg gccgtgcgcg cgccctcccc cgaggagatg gaggaggagg cgatcgccag    480

cctcccgggg gaagagacgg aggatatgga ctttctgtct gggctggaac tggcggatct    540

cctggacccc aggcaaccgg actggcacct ggaccccggg cttagctcgc cggggcctct    600

ctcctcgtct ggcggaggct cggatagcgg cggcctgtgg agaggggacg atgacgatga    660

ggccgcggct gctgaaatgc agcgcttctc tgacctgctg caaaggctgt taaacggtat    720

cggaggctgc agcagcagca gtgacagtgg cagcgccgaa aagaggcgga gaaagtcccc    780

aggaggaggc ggcggtggcg gcagcggtaa cgacaacaac caggcggcga caaagagtcc    840

ccggaaggcg gcggcggccg ctgcccgcct taatcgactg aagaagaagg agtacgtgat    900

ggggctggag agtcgagtcc ggggtctggc agccgagaac caggagctgc gggccgagaa    960

tcgggagctg ggcaaacgcg tacaggcact gcaggaggag agtcgctacc tacgggcagt   1020

cttagccaac gagactggac tggctcgctt gctgagccgg ctgagcggcg tgggactgcg   1080

gctgaccacc tcgctcttca gagactcgcc cgccggtgac cacgactacg ctctgccagt   1140

gggaaagcag aagcaggacc tgctggaaga ggacgactcg gcgggaggag tctgtctcca   1200

tgtggacaag gataaggtgt cggtggagtt ctgctcggcg tgcgcccgga aggcgtcgtc   1260

ttctcttaaa atgtagggtc aagtaatctg ctctttatcc gcgtttaccc ctttcaactc   1320

ccttacacca tgtcaaactt accttagtgg gacatcttca ccggacacat ttcagaggag   1380

agaaaaaaag taatattgaa tcttaaagtg tttagctaaa agcatgaatg tgacacagta   1440

accaactcct aatgataaca tgtgactatt aaatctctct gacagtttct tttttaggtg   1500

atttccttcc tgccaggctc cgttgtaggg gttacagaac agtcgttccc gcctcacaac   1560

ctgtggatac agctgttggg gcagaagaga cgggaccagc tgctggccac atttcctgct   1620

ttattttaaa aggtagtata agaatgagga aaaagaggta atatcagggc ttctgctgtt   1680

ttttattttt aacatgttca taattaaaaa gtattttcca gcagtccaaa gatgtaagtt   1740

atcttacaca taatatgttt tattttgtta tttggttatg aaaatggaat ccttgttctt   1800

gcacaactgt aaatgttttg ttgctagata atacgatttg agacctgaat tggtctttgg   1860

tttccagtgc atcacagcat attttgtaaa atcatgtact actgcacttg agcatgaatg   1920

ggtagtagcc aaactcacaa attggagtga tgaacctgct tatacctaag ggcaggagca   1980

agcccctcac aatgcagctg catgggtttt tagtgcctac tgaattatat atatatatac   2040

atatatatat atatatataa accaaaagta gttggaaaga ttatttgaaa tgactaactt   2100

tgtgctatct ttatgaaata tgttaaatgt agcttttttg aaacagaagc cttgaattga   2160

aatttaacta atacttgaac attttgtata tatttctttg tatataattt tgtgcagtac   2220

caatgacaaa aatatggtgt cataataaaa ccaggtttgt tgatctttta gttatgggct   2280

caaagaattt attcatctct aacatgatat tggaaaataa tggatgaaaa taggaaaaat   2340

gattgttaat gctgactgtg ggtcttaaaa ggttctggaa agcagtaagt tcatttttct   2400

aaaaactata acattctgtt ggagtatttt cttccttacg tcaatacttt tcctgcatta   2460

tttgaaattg tgggctgggg agaaacagta gtcaaagctt tctgaattga gatactttga   2520

aattccaagt gtagattttt agaatgtcat tttataaatg gccgtttttg gaattacttg   2580

ataagaactt ttgaaaatgg aaggattagt atggcctatt tttaaagctg ctttgttagg   2640

ttccttatgt tttattaact gtcttttctc agtttccatt tcattttttt ttttctagtt   2700

ttggtgactt agtgattttg tcatttttta catcaacttc atggtcttgt ttttacatgg   2760

taattgcatg tacttaggat ctatctaata ggggctttaa ataaatttgg tcatatttat   2820

gtgtaagcac attttactgt aaatgtttgg gtttctgaat ttaaacagat ctgtttattt   2880

cagtatgtag taaacaatat cttaaagtgt ccgattcact acttgttaat taaaaaagtt   2940

atgattaatg tg                                                       2952


<210>  1278
<211>  272
<212>  PRT
<213>  Homosapiens

<400>  1278

Met Glu Glu Glu Ala Ile Ala Ser Leu Pro Gly Glu Glu Thr Glu Asp 
1               5                   10                  15      


Met Asp Phe Leu Ser Gly Leu Glu Leu Ala Asp Leu Leu Asp Pro Arg 
            20                  25                  30          


Gln Pro Asp Trp His Leu Asp Pro Gly Leu Ser Ser Pro Gly Pro Leu 
        35                  40                  45              


Ser Ser Ser Gly Gly Gly Ser Asp Ser Gly Gly Leu Trp Arg Gly Asp 
    50                  55                  60                  


Asp Asp Asp Glu Ala Ala Ala Ala Glu Met Gln Arg Phe Ser Asp Leu 
65                  70                  75                  80  


Leu Gln Arg Leu Leu Asn Gly Ile Gly Gly Cys Ser Ser Ser Ser Asp 
                85                  90                  95      


Ser Gly Ser Ala Glu Lys Arg Arg Arg Lys Ser Pro Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Asn Asp Asn Asn Gln Ala Ala Thr Lys Ser Pro 
        115                 120                 125             


Arg Lys Ala Ala Ala Ala Ala Ala Arg Leu Asn Arg Leu Lys Lys Lys 
    130                 135                 140                 


Glu Tyr Val Met Gly Leu Glu Ser Arg Val Arg Gly Leu Ala Ala Glu 
145                 150                 155                 160 


Asn Gln Glu Leu Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg Val Gln 
                165                 170                 175     


Ala Leu Gln Glu Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala Asn Glu 
            180                 185                 190         


Thr Gly Leu Ala Arg Leu Leu Ser Arg Leu Ser Gly Val Gly Leu Arg 
        195                 200                 205             


Leu Thr Thr Ser Leu Phe Arg Asp Ser Pro Ala Gly Asp His Asp Tyr 
    210                 215                 220                 


Ala Leu Pro Val Gly Lys Gln Lys Gln Asp Leu Leu Glu Glu Asp Asp 
225                 230                 235                 240 


Ser Ala Gly Gly Val Cys Leu His Val Asp Lys Asp Lys Val Ser Val 
                245                 250                 255     


Glu Phe Cys Ser Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu Lys Met 
            260                 265                 270         


<210>  1279
<211>  2428
<212>  DNA
<213>  Homosapiens

<400>  1279
gttacttcat agcattctga agacctgtcc accaattaca gggctcctta ctggaaaaac     60

caactgctgg ggagtgccaa gagaccctag caacaccctg cagcgtttga aatctgaggg    120

gaaaagactg tagtcagccc ttagtggatg agagcgccta tgctccagaa acagcaggct    180

cccaggatgg acaccccgcc ccctgaagaa cgcttagaga agcaaaatga aaaactgaac    240

aaccaggaag aggagacgga gtttaaggaa ctggacggtc tgagggaagc cttggcaaac    300

ctccggggac tgtcagagga ggagaggagc gagaaggcta tgcttcgctc ccgcattgaa    360

gagcagtccc agctcatctg catcctgaag cggaggtcag atgaggccct ggagcgctgc    420

cagatcctag agctgctcaa tgcagagctg gaggagaaga tgatgcagga ggctgagaag    480

ctcaaggccc agggtgagta cagtcggaaa ctagaggaac gctttatgac cctagcagcc    540

aaccacgagt tgatgctccg cttcaaggat gaatacaaga gtgagaacat caagctgagg    600

gaggagaatg agaagctgag gctggagaat agcagcctct tcagccaggc tctgaaggat    660

gaggaggcga aagtattaca gctcacagtc cggtgtgagg ccctcactgg ggagctagaa    720

acgctgaagg agaggtgtgc tcaggatgcc tgccaggcac aggcgcgcga gaaggagctg    780

ctggagctac agagccagca ggcctgcacc cacaccaagg agacagaaca gctgcgcagc    840

cagctgcaga ccctcaagca gcagcaccag caggctgtgg agcagatagc taaggcagag    900

gagacacaca gcagcctgag ccaggagctg caggccaggc tgcagaccgt cactagagag    960

aaagaggagt tgctgcagct gtccattgaa aggggcaaag tgcttcagaa caaacaggca   1020

gagatctgcc agcttgagga aaagttggag atagcaaatg aagacaggaa gcatgcgctg   1080

gagcggtttg agcaagaggc agtggctgtg gacagcaact tgagagtcag ggagcttcag   1140

cgcaaagtag atgggatcca gaaggcctac gatgaactca ggctgcagtc tgaagccttc   1200

aaaaagcaca gcttggatct tttaagcaag gagagagaac tcaatggcaa actccgccat   1260

ctctctccat agggaagttt ctgcttcctc tggcctgcaa ttcagaattc aaatatttgc   1320

gtcttagcat tatggcaaga gtaaagatga tatcccattt attatacttt caagcacaaa   1380

aggcaactca aagaaaagct actttactat gatattgttg ttattattgt aaagccatta   1440

ttaattttca tttctacacc tagaatacac aagatttgcc agatttcctt ctgtgcctta   1500

gaaatcttaa atttactagt agtatcttct cctacccata agttattaat tctcaacctc   1560

agatatcttc atttatgtta ggattttaaa ttagcagctt ctatgattta agtcaatcta   1620

agtgcagtga gatgtgccat tgtgaaaaat aattagcaca attacccact gtagatagtt   1680

aggcttatag tctcccatag ttgagattgt aagcaaacat gtatcagcat aatagcatga   1740

atgctttgca gaaaaaaaaa agtgtctgac tttattttat tttgcgctag cttggaaaat   1800

gattgagatc aagttcttta acaaagaagg tcaattttat tctgtatgag caatatgatt   1860

caaataagtt atacaaaaca acttttattt tttctgcaag cttagataat attccatttt   1920

ttggttttct ctttaaaaag aggatttaga tgtgcaataa tgcaaatatc agtagcttaa   1980

tttaatattg cacgatatgc taatagacaa ttagacaatt tggggtaaca aatcatagca   2040

gacgtgatct atagagtaac tcagaaattg ttttgtttct attagcatat tttttgtaat   2100

taagattttc cttttttaaa aaaatctaag ctgaacgtgt gtatgtatgc ttgcagcatt   2160

tttgtagtaa tacctacatt ttgtaagaat agttataaaa acatgatata tatatatgta   2220

aagttcttaa aaaagttctc aaaggtagtt atattttctt atcttcctgt aattaggtat   2280

tgatatataa acattattat gaatacctct caaaatagat tgtaatgtaa tatttttctc   2340

acccattttg ctgaaggcta ccaagttaca taatgaattt acttaaaaaa tatgacttgg   2400

tgccttttta gtaaaaccat ttccaagc                                      2428


<210>  1280
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  1280

Met Arg Ala Pro Met Leu Gln Lys Gln Gln Ala Pro Arg Met Asp Thr 
1               5                   10                  15      


Pro Pro Pro Glu Glu Arg Leu Glu Lys Gln Asn Glu Lys Leu Asn Asn 
            20                  25                  30          


Gln Glu Glu Glu Thr Glu Phe Lys Glu Leu Asp Gly Leu Arg Glu Ala 
        35                  40                  45              


Leu Ala Asn Leu Arg Gly Leu Ser Glu Glu Glu Arg Ser Glu Lys Ala 
    50                  55                  60                  


Met Leu Arg Ser Arg Ile Glu Glu Gln Ser Gln Leu Ile Cys Ile Leu 
65                  70                  75                  80  


Lys Arg Arg Ser Asp Glu Ala Leu Glu Arg Cys Gln Ile Leu Glu Leu 
                85                  90                  95      


Leu Asn Ala Glu Leu Glu Glu Lys Met Met Gln Glu Ala Glu Lys Leu 
            100                 105                 110         


Lys Ala Gln Gly Glu Tyr Ser Arg Lys Leu Glu Glu Arg Phe Met Thr 
        115                 120                 125             


Leu Ala Ala Asn His Glu Leu Met Leu Arg Phe Lys Asp Glu Tyr Lys 
    130                 135                 140                 


Ser Glu Asn Ile Lys Leu Arg Glu Glu Asn Glu Lys Leu Arg Leu Glu 
145                 150                 155                 160 


Asn Ser Ser Leu Phe Ser Gln Ala Leu Lys Asp Glu Glu Ala Lys Val 
                165                 170                 175     


Leu Gln Leu Thr Val Arg Cys Glu Ala Leu Thr Gly Glu Leu Glu Thr 
            180                 185                 190         


Leu Lys Glu Arg Cys Ala Gln Asp Ala Cys Gln Ala Gln Ala Arg Glu 
        195                 200                 205             


Lys Glu Leu Leu Glu Leu Gln Ser Gln Gln Ala Cys Thr His Thr Lys 
    210                 215                 220                 


Glu Thr Glu Gln Leu Arg Ser Gln Leu Gln Thr Leu Lys Gln Gln His 
225                 230                 235                 240 


Gln Gln Ala Val Glu Gln Ile Ala Lys Ala Glu Glu Thr His Ser Ser 
                245                 250                 255     


Leu Ser Gln Glu Leu Gln Ala Arg Leu Gln Thr Val Thr Arg Glu Lys 
            260                 265                 270         


Glu Glu Leu Leu Gln Leu Ser Ile Glu Arg Gly Lys Val Leu Gln Asn 
        275                 280                 285             


Lys Gln Ala Glu Ile Cys Gln Leu Glu Glu Lys Leu Glu Ile Ala Asn 
    290                 295                 300                 


Glu Asp Arg Lys His Ala Leu Glu Arg Phe Glu Gln Glu Ala Val Ala 
305                 310                 315                 320 


Val Asp Ser Asn Leu Arg Val Arg Glu Leu Gln Arg Lys Val Asp Gly 
                325                 330                 335     


Ile Gln Lys Ala Tyr Asp Glu Leu Arg Leu Gln Ser Glu Ala Phe Lys 
            340                 345                 350         


Lys His Ser Leu Asp Leu Leu Ser Lys Glu Arg Glu Leu Asn Gly Lys 
        355                 360                 365             


Leu Arg His Leu Ser Pro 
    370                 


<210>  1281
<211>  4759
<212>  DNA
<213>  Homosapiens

<400>  1281
ctaaaagaaa gaatggatga acccaatgca gaacaggtct ataatccctc tcagtttgag     60

aatttgagaa agttttggga cttagaagct aattcaaaca gtaaggataa tgacaagaat    120

attaccacca caagccaaaa aaattctgca ccttttaata ggcagaaaca caaggaattc    180

agcgacatta aattatcagg taaaaatacc catgaagcag aggtgcttct aagcccaaaa    240

aaagttatgg caagagagga aatggagaaa ttaaattcaa agggcatact ccaggtgcta    300

ccagatgaaa tcacatttcc tttgagtcca cttagaaagt atacttatca gttgccagga    360

aatgagtcat caaaggaaaa tgtggaaaag aatacggaag ggattgttac tccagtgttt    420

aaggaagaaa aggattactc agaacaagag attcaagaat ccataataaa aaccaatgtt    480

ttgtctaaag actgcaaaga cacttttaat gacagcttgc agaaactgct ttcagaaacc    540

tcaacaccag caattcaacc ctctggtgga aaagttcatg gaaaacaagt gcttgaacca    600

agtgtttctg aaaataggac atggcctcaa aaaacagatt ttgctgatac tgaggaagaa    660

gtcaaaggac ctgagaagat cattaatgag catgttgaca aaacagtagt tcatccaaag    720

gttaaacgga actctttgac tgctagtcta gacaaactcc tgaaggaagc aactggaact    780

tcaccctctc ccttgcaagc caagttggcg cccgttatca ctggaaccaa ctctaagctg    840

gaagagggga gattttttgg aaaagggata gaacagagtc acaatacttc agctgataag    900

agagaaatac tagctccttt tccagtgaga gatgaaactt ttggaaatac agctctcctc    960

aagaaagctg aaagtggtga gtgccagcta agcacacaga atttgattca gatggctgca   1020

gaagattctc atccattgga tccaacttcc cagctttcca gaaagggttc ttttggggat   1080

gtggccagcc ctccccaaga tatgcttttt ccccaggatg ctcatcttgt tccccaggct   1140

agggtacacc cttctcaaac ggaaatttcg gagactgtag agaaagtcat tcttccaccc   1200

agacctgtat tgaatgatgt aagtgctgca ttacagaagc tgtgtggaga agtatggtta   1260

agttatccag ctggaaggga agtaggtcct ggagaagtga acccagaatt tcctgaagca   1320

gtacagccag tatgtagccc cctaaatcct ccaggagtga tatcaccatg ggctacgatg   1380

gacaccatag ttccagacag gaaggatttt tattcctcca atgtagttcc tgataaaact   1440

catgaagttg gatcttattt agctgcccaa atgtctccat cagaccagac gcttagctca   1500

tttgcttcca ttgttgctca atatggcaaa ggcctccctc aggaagtgga agaaattgtg   1560

agggaaacaa ttgttcaacc caaatcagag ttcctcgaat tcagtgctgg cttagaaaaa   1620

ctactgaagg aagaaactga aaccttcccc tcaaaatatg aaagtgatac agggaatctt   1680

tctccatcaa agttaatagg tagtacagag gagcccaggc gagccacttc tgaatgccat   1740

cctgaggaat taaaagaaac agtagaaaag gccgaggctc cgttaataac tgagagtgct   1800

tttgatgctg gttttgagaa acttcttaaa gaaataactg aagctcctcc ttatcagccc   1860

caggtgtcag tgagagaaga aactcacgag aaggagtcct cacagtcaga gcagaccagg   1920

ttcttgggga cagtgcccca tttttacagg gcagcctcac agacctctga aatgaaggat   1980

aaaagtaatg gtttggaatc tcaagtcaac caatgtgata aaatgttggg aggagacgca   2040

cttgtgactg atttattggt agatttttgt ggttccagaa gtggagttga gatccctaga   2100

accccacaac tttatgtggc tcatgaaata gggaccatta aaactgtaac ccccccagag   2160

gacagggaca gtgaaagtgg ggttgcaggg ggacaaggga ctcttcagga acctggcttt   2220

ggagaggctt ctgaagcaat tagtgtgtcc agaaataggc aacccattcc tctcctgatg   2280

aacaaagaaa actctacaaa aacaagtaaa gttgaattga ctctagcatc gccatatatg   2340

aaacaagaga aagaggaaga aaaagaaggt ttctctgagt ctgatttttc agatggaaac   2400

accagttcta atgcagagag ctggagaaat ccttccagtt cagaagaaga acccagtcct   2460

gttttgaaaa ctttggaaag gagtgccgct aggaaaatgc cttccaaaag tctagaagac   2520

atttcatcag attcatcaaa tcaagcaaaa gtagataatc agccagaaga attagtgcgt   2580

agtgctgaag atgtttccac agtgcctaca caacctgata atccattttc tcaccctgac   2640

aaactcaaaa ggatgagcaa gtctgttcca gcatttctcc aagatgagag tgatgacaga   2700

gaaacagata cagcatcaga aagcagttac cagctcagca gacacaagaa gagcccgagc   2760

tctttaacca atcttagcag ctcctctggc atgacgtcct tgtcttctgt gagtggcagt   2820

gtgatgagtg tttatagtgg agactttggc aatctggaag ttaaaggaaa tattcagttt   2880

gcaattgaat atgtggagtc actgaaggag ttgcatgttt ttgtggccca gtgtaaggac   2940

ttagcagcag cggatgtaaa aaaacagcgt tcagacccat atgtaaaggc ctatttgcta   3000

ccagacaaag gcaaaatggg caagaagaaa acactcgtag tgaagaaaac cttgaatcct   3060

gtgtataacg aaatactgcg gtataaaatt gaaaaacaaa tcttaaagac acagaaattg   3120

aacctgtcca tttggcatcg ggatacattt aagcgcaata gtttcctagg ggaggtggaa   3180

cttgatttgg aaacatggga ctgggataac aaacagaata aacaattgag atggtaccct   3240

ctgaagcgga agacagcacc agttgccctt gaagcagaaa acagaggtga aatgaaacta   3300

gctctccagt atgtcccaga gccagtccct ggtaaaaagc ttcctacaac tggagaagtg   3360

cacatctggg tgaaggaatg ccttgatcta ccactgctaa ggggaagtca tctaaattct   3420

tttgttaaat gtaccatcct tccagataca agtaggaaaa gtcgccagaa gacaagagct   3480

gtagggaaaa ccaccaaccc tatcttcaac cacactatgg tgtatgatgg gttcaggcct   3540

gaagatctga tggaagcctg tgtagagctt actgtctggg accattacaa attaaccaac   3600

caatttttgg gaggtcttcg tattggcttt ggaacaggta aaagttatgg gactgaagtg   3660

gactggatgg actctacttc agaggaagtt gctctctggg agaagatggt aaactccccc   3720

aatacttgga ttgaagcaac actgcctctc agaatgcttt tgattgccaa gatttccaaa   3780

tgagcccaaa ttccactggc tcctccactg aaaactacta aaccggtgga atctgatctt   3840

gaaaatctga gtaggtggac aaatatcctc actttctatc tattgcacct aaggaatact   3900

acacagcatg taaaagtcaa tctgcatgtg cttctttgat tacaaggccc aagggattta   3960

aatataacaa aatgtgtaat ttgtgactct aatattaaat aagatatttg aacaagctag   4020

gaaaattgaa tttctgctgc tgcttcaaag aaaaagctgc cccagagcat taaacatggg   4080

gtattgttaa gaagcaaaat gttcttgttt gccatcatgt gtttcacacc acaattctgt   4140

gccacagtta agagggtctg gtacccttgc aggacctttg taggttgtgg gaaaaagtcg   4200

cagaaagata ctcaaagtgg agcagggaat ggagacagac atcagtgatg ataaaaaaaa   4260

aaatggacct taagaaacta tttactctgt aatctctaat aaaatatgga attccatatt   4320

agggcaatga gactgaaact actggtgttt ttctgccttg agaaaacaaa cagttaaaac   4380

aagcctcaaa tgtattttag tgccacccac tggccatagg tacaattcag ttgttggctt   4440

gttttgactt aattctaaaa taggtctcaa gcctgtattt ttatgagttt atttttttaa   4500

aaccctgcat atatatgatt gtttttctta taactttact atatgaaagc agcataagag   4560

tagtcacaaa catgttttgc aacaaagttt taattagaat gtaagttgct cagttatact   4620

gttcttctta tgtatgtaaa attttcgtat tttgtaaaaa cccttagaat aaattatcat   4680

ttgatttaaa ttgtattaga aaattagcgt gacttctcat tttaaataaa atattttagg   4740

aattctaaac atctaaaaa                                                4759


<210>  1282
<211>  1256
<212>  PRT
<213>  Homosapiens

<400>  1282

Met Asp Glu Pro Asn Ala Glu Gln Val Tyr Asn Pro Ser Gln Phe Glu 
1               5                   10                  15      


Asn Leu Arg Lys Phe Trp Asp Leu Glu Ala Asn Ser Asn Ser Lys Asp 
            20                  25                  30          


Asn Asp Lys Asn Ile Thr Thr Thr Ser Gln Lys Asn Ser Ala Pro Phe 
        35                  40                  45              


Asn Arg Gln Lys His Lys Glu Phe Ser Asp Ile Lys Leu Ser Gly Lys 
    50                  55                  60                  


Asn Thr His Glu Ala Glu Val Leu Leu Ser Pro Lys Lys Val Met Ala 
65                  70                  75                  80  


Arg Glu Glu Met Glu Lys Leu Asn Ser Lys Gly Ile Leu Gln Val Leu 
                85                  90                  95      


Pro Asp Glu Ile Thr Phe Pro Leu Ser Pro Leu Arg Lys Tyr Thr Tyr 
            100                 105                 110         


Gln Leu Pro Gly Asn Glu Ser Ser Lys Glu Asn Val Glu Lys Asn Thr 
        115                 120                 125             


Glu Gly Ile Val Thr Pro Val Phe Lys Glu Glu Lys Asp Tyr Ser Glu 
    130                 135                 140                 


Gln Glu Ile Gln Glu Ser Ile Ile Lys Thr Asn Val Leu Ser Lys Asp 
145                 150                 155                 160 


Cys Lys Asp Thr Phe Asn Asp Ser Leu Gln Lys Leu Leu Ser Glu Thr 
                165                 170                 175     


Ser Thr Pro Ala Ile Gln Pro Ser Gly Gly Lys Val His Gly Lys Gln 
            180                 185                 190         


Val Leu Glu Pro Ser Val Ser Glu Asn Arg Thr Trp Pro Gln Lys Thr 
        195                 200                 205             


Asp Phe Ala Asp Thr Glu Glu Glu Val Lys Gly Pro Glu Lys Ile Ile 
    210                 215                 220                 


Asn Glu His Val Asp Lys Thr Val Val His Pro Lys Val Lys Arg Asn 
225                 230                 235                 240 


Ser Leu Thr Ala Ser Leu Asp Lys Leu Leu Lys Glu Ala Thr Gly Thr 
                245                 250                 255     


Ser Pro Ser Pro Leu Gln Ala Lys Leu Ala Pro Val Ile Thr Gly Thr 
            260                 265                 270         


Asn Ser Lys Leu Glu Glu Gly Arg Phe Phe Gly Lys Gly Ile Glu Gln 
        275                 280                 285             


Ser His Asn Thr Ser Ala Asp Lys Arg Glu Ile Leu Ala Pro Phe Pro 
    290                 295                 300                 


Val Arg Asp Glu Thr Phe Gly Asn Thr Ala Leu Leu Lys Lys Ala Glu 
305                 310                 315                 320 


Ser Gly Glu Cys Gln Leu Ser Thr Gln Asn Leu Ile Gln Met Ala Ala 
                325                 330                 335     


Glu Asp Ser His Pro Leu Asp Pro Thr Ser Gln Leu Ser Arg Lys Gly 
            340                 345                 350         


Ser Phe Gly Asp Val Ala Ser Pro Pro Gln Asp Met Leu Phe Pro Gln 
        355                 360                 365             


Asp Ala His Leu Val Pro Gln Ala Arg Val His Pro Ser Gln Thr Glu 
    370                 375                 380                 


Ile Ser Glu Thr Val Glu Lys Val Ile Leu Pro Pro Arg Pro Val Leu 
385                 390                 395                 400 


Asn Asp Val Ser Ala Ala Leu Gln Lys Leu Cys Gly Glu Val Trp Leu 
                405                 410                 415     


Ser Tyr Pro Ala Gly Arg Glu Val Gly Pro Gly Glu Val Asn Pro Glu 
            420                 425                 430         


Phe Pro Glu Ala Val Gln Pro Val Cys Ser Pro Leu Asn Pro Pro Gly 
        435                 440                 445             


Val Ile Ser Pro Trp Ala Thr Met Asp Thr Ile Val Pro Asp Arg Lys 
    450                 455                 460                 


Asp Phe Tyr Ser Ser Asn Val Val Pro Asp Lys Thr His Glu Val Gly 
465                 470                 475                 480 


Ser Tyr Leu Ala Ala Gln Met Ser Pro Ser Asp Gln Thr Leu Ser Ser 
                485                 490                 495     


Phe Ala Ser Ile Val Ala Gln Tyr Gly Lys Gly Leu Pro Gln Glu Val 
            500                 505                 510         


Glu Glu Ile Val Arg Glu Thr Ile Val Gln Pro Lys Ser Glu Phe Leu 
        515                 520                 525             


Glu Phe Ser Ala Gly Leu Glu Lys Leu Leu Lys Glu Glu Thr Glu Thr 
    530                 535                 540                 


Phe Pro Ser Lys Tyr Glu Ser Asp Thr Gly Asn Leu Ser Pro Ser Lys 
545                 550                 555                 560 


Leu Ile Gly Ser Thr Glu Glu Pro Arg Arg Ala Thr Ser Glu Cys His 
                565                 570                 575     


Pro Glu Glu Leu Lys Glu Thr Val Glu Lys Ala Glu Ala Pro Leu Ile 
            580                 585                 590         


Thr Glu Ser Ala Phe Asp Ala Gly Phe Glu Lys Leu Leu Lys Glu Ile 
        595                 600                 605             


Thr Glu Ala Pro Pro Tyr Gln Pro Gln Val Ser Val Arg Glu Glu Thr 
    610                 615                 620                 


His Glu Lys Glu Ser Ser Gln Ser Glu Gln Thr Arg Phe Leu Gly Thr 
625                 630                 635                 640 


Val Pro His Phe Tyr Arg Ala Ala Ser Gln Thr Ser Glu Met Lys Asp 
                645                 650                 655     


Lys Ser Asn Gly Leu Glu Ser Gln Val Asn Gln Cys Asp Lys Met Leu 
            660                 665                 670         


Gly Gly Asp Ala Leu Val Thr Asp Leu Leu Val Asp Phe Cys Gly Ser 
        675                 680                 685             


Arg Ser Gly Val Glu Ile Pro Arg Thr Pro Gln Leu Tyr Val Ala His 
    690                 695                 700                 


Glu Ile Gly Thr Ile Lys Thr Val Thr Pro Pro Glu Asp Arg Asp Ser 
705                 710                 715                 720 


Glu Ser Gly Val Ala Gly Gly Gln Gly Thr Leu Gln Glu Pro Gly Phe 
                725                 730                 735     


Gly Glu Ala Ser Glu Ala Ile Ser Val Ser Arg Asn Arg Gln Pro Ile 
            740                 745                 750         


Pro Leu Leu Met Asn Lys Glu Asn Ser Thr Lys Thr Ser Lys Val Glu 
        755                 760                 765             


Leu Thr Leu Ala Ser Pro Tyr Met Lys Gln Glu Lys Glu Glu Glu Lys 
    770                 775                 780                 


Glu Gly Phe Ser Glu Ser Asp Phe Ser Asp Gly Asn Thr Ser Ser Asn 
785                 790                 795                 800 


Ala Glu Ser Trp Arg Asn Pro Ser Ser Ser Glu Glu Glu Pro Ser Pro 
                805                 810                 815     


Val Leu Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys 
            820                 825                 830         


Ser Leu Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp 
        835                 840                 845             


Asn Gln Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Val Ser Thr Val 
    850                 855                 860                 


Pro Thr Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg 
865                 870                 875                 880 


Met Ser Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Ser Asp Asp Arg 
                885                 890                 895     


Glu Thr Asp Thr Ala Ser Glu Ser Ser Tyr Gln Leu Ser Arg His Lys 
            900                 905                 910         


Lys Ser Pro Ser Ser Leu Thr Asn Leu Ser Ser Ser Ser Gly Met Thr 
        915                 920                 925             


Ser Leu Ser Ser Val Ser Gly Ser Val Met Ser Val Tyr Ser Gly Asp 
    930                 935                 940                 


Phe Gly Asn Leu Glu Val Lys Gly Asn Ile Gln Phe Ala Ile Glu Tyr 
945                 950                 955                 960 


Val Glu Ser Leu Lys Glu Leu His Val Phe Val Ala Gln Cys Lys Asp 
                965                 970                 975     


Leu Ala Ala Ala Asp Val Lys Lys Gln Arg Ser Asp Pro Tyr Val Lys 
            980                 985                 990         


Ala Tyr Leu Leu Pro Asp Lys Gly  Lys Met Gly Lys Lys  Lys Thr Leu 
        995                 1000                 1005             


Val Val  Lys Lys Thr Leu Asn  Pro Val Tyr Asn Glu  Ile Leu Arg 
    1010                 1015                 1020             


Tyr Lys  Ile Glu Lys Gln Ile  Leu Lys Thr Gln Lys  Leu Asn Leu 
    1025                 1030                 1035             


Ser Ile  Trp His Arg Asp Thr  Phe Lys Arg Asn Ser  Phe Leu Gly 
    1040                 1045                 1050             


Glu Val  Glu Leu Asp Leu Glu  Thr Trp Asp Trp Asp  Asn Lys Gln 
    1055                 1060                 1065             


Asn Lys  Gln Leu Arg Trp Tyr  Pro Leu Lys Arg Lys  Thr Ala Pro 
    1070                 1075                 1080             


Val Ala  Leu Glu Ala Glu Asn  Arg Gly Glu Met Lys  Leu Ala Leu 
    1085                 1090                 1095             


Gln Tyr  Val Pro Glu Pro Val  Pro Gly Lys Lys Leu  Pro Thr Thr 
    1100                 1105                 1110             


Gly Glu  Val His Ile Trp Val  Lys Glu Cys Leu Asp  Leu Pro Leu 
    1115                 1120                 1125             


Leu Arg  Gly Ser His Leu Asn  Ser Phe Val Lys Cys  Thr Ile Leu 
    1130                 1135                 1140             


Pro Asp  Thr Ser Arg Lys Ser  Arg Gln Lys Thr Arg  Ala Val Gly 
    1145                 1150                 1155             


Lys Thr  Thr Asn Pro Ile Phe  Asn His Thr Met Val  Tyr Asp Gly 
    1160                 1165                 1170             


Phe Arg  Pro Glu Asp Leu Met  Glu Ala Cys Val Glu  Leu Thr Val 
    1175                 1180                 1185             


Trp Asp  His Tyr Lys Leu Thr  Asn Gln Phe Leu Gly  Gly Leu Arg 
    1190                 1195                 1200             


Ile Gly  Phe Gly Thr Gly Lys  Ser Tyr Gly Thr Glu  Val Asp Trp 
    1205                 1210                 1215             


Met Asp  Ser Thr Ser Glu Glu  Val Ala Leu Trp Glu  Lys Met Val 
    1220                 1225                 1230             


Asn Ser  Pro Asn Thr Trp Ile  Glu Ala Thr Leu Pro  Leu Arg Met 
    1235                 1240                 1245             


Leu Leu  Ile Ala Lys Ile Ser  Lys 
    1250                 1255     


<210>  1283
<211>  2447
<212>  DNA
<213>  Homosapiens

<400>  1283
acagaagaat agagaggctg ttgcagcccc gtgctttctc ctgctgctgg ccgattgctt     60

gctctgaact aaccctctaa cccttgggag tctgtgtgca gcagtgatgt gagctgcatc    120

cgggctgaaa tgggagctcc cgctatggca ctggctcaag gagctaatct aaagagaaaa    180

tcaagcaaaa gtagataatc agccagaaga attagtgcgt agtgctgaag atgatgagaa    240

accagatcag aagccagtta caaatgaatg cgtaccaaga atttccacag tgcctacaca    300

acctgataat ccattttctc accctgacaa actcaaaagg atgagcaagt ctgttccagc    360

atttctccaa gatgagagtg atgacagaga aacagataca gcatcagaaa gcagttacca    420

gctcagcaga cacaagaaga gcccgagctc tttaaccaat cttagcagct cctctggcat    480

gacgtccttg tcttctgtga gtggcagtgt gatgagtgtt tatagtggag actttggcaa    540

tctggaagtt aaaggaaata ttcagtttgc aattgaatat gtggagtcac tgaaggagtt    600

gcatgttttt gtggcccagt gtaaggactt agcagcagcg gatgtaaaaa aacagcgttc    660

agacccatat gtaaaggcct atttgctacc agacaaaggc aaaatgggca agaagaaaac    720

actcgtagtg aagaaaacct tgaatcctgt gtataacgaa atactgcggt ataaaattga    780

aaaacaaatc ttaaagacac agaaattgaa cctgtccatt tggcatcggg atacatttaa    840

gcgcaatagt ttcctagggg aggtggaact tgatttggaa acatgggact gggataacaa    900

acagaataaa caattgagat ggtaccctct gaagcggaag acagcaccag ttgcccttga    960

agcagaaaac agaggtgaaa tgaaactagc tctccagtat gtcccagagc cagtccctgg   1020

taaaaagctt cctacaactg gagaagtgca catctgggtg aaggaatgcc ttgatctacc   1080

actgctaagg ggaagtcatc taaattcttt tgttaaatgt accatccttc cagatacaag   1140

taggaaaagt cgccagaaga caagagctgt agggaaaacc accaacccta tcttcaacca   1200

cactatggtg tatgatgggt tcaggcctga agatctgatg gaagcctgtg tagagcttac   1260

tgtctgggac cattacaaat taaccaacca atttttggga ggtcttcgta ttggctttgg   1320

aacaggtaaa agttatggga ctgaagtgga ctggatggac tctacttcag aggaagttgc   1380

tctctgggag aagatggtaa actcccccaa tacttggatt gaagcaacac tgcctctcag   1440

aatgcttttg attgccaaga tttccaaatg agcccaaatt ccactggctc ctccactgaa   1500

aactactaaa ccggtggaat ctgatcttga aaatctgagt aggtggacaa atatcctcac   1560

tttctatcta ttgcacctaa ggaatactac acagcatgta aaagtcaatc tgcatgtgct   1620

tctttgatta caaggcccaa gggatttaaa tataacaaaa tgtgtaattt gtgactctaa   1680

tattaaataa gatatttgaa caagctagga aaattgaatt tctgctgctg cttcaaagaa   1740

aaagctgccc cagagcatta aacatggggt attgttaaga agcaaaatgt tcttgtttgc   1800

catcatgtgt ttcacaccac aattctgtgc cacagttaag agggtctggt acccttgcag   1860

gacctttgta ggttgtggga aaaagtcgca gaaagatact caaagtggag cagggaatgg   1920

agacagacat cagtgatgat aaaaaaaaaa atggacctta agaaactatt tactctgtaa   1980

tctctaataa aatatggaat tccatattag ggcaatgaga ctgaaactac tggtgttttt   2040

ctgccttgag aaaacaaaca gttaaaacaa gcctcaaatg tattttagtg ccacccactg   2100

gccataggta caattcagtt gttggcttgt tttgacttaa ttctaaaata ggtctcaagc   2160

ctgtattttt atgagtttat ttttttaaaa ccctgcatat atatgattgt ttttcttata   2220

actttactat atgaaagcag cataagagta gtcacaaaca tgttttgcaa caaagtttta   2280

attagaatgt aagttgctca gttatactgt tcttcttatg tatgtaaaat tttcgtattt   2340

tgtaaaaacc cttagaataa attatcattt gatttaaatt gtattagaaa attagcgtga   2400

cttctcattt taaataaaat attttaggaa ttctaaacat ctaaaaa                 2447


<210>  1284
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  1284

Met Ser Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Ser Asp Asp Arg 
1               5                   10                  15      


Glu Thr Asp Thr Ala Ser Glu Ser Ser Tyr Gln Leu Ser Arg His Lys 
            20                  25                  30          


Lys Ser Pro Ser Ser Leu Thr Asn Leu Ser Ser Ser Ser Gly Met Thr 
        35                  40                  45              


Ser Leu Ser Ser Val Ser Gly Ser Val Met Ser Val Tyr Ser Gly Asp 
    50                  55                  60                  


Phe Gly Asn Leu Glu Val Lys Gly Asn Ile Gln Phe Ala Ile Glu Tyr 
65                  70                  75                  80  


Val Glu Ser Leu Lys Glu Leu His Val Phe Val Ala Gln Cys Lys Asp 
                85                  90                  95      


Leu Ala Ala Ala Asp Val Lys Lys Gln Arg Ser Asp Pro Tyr Val Lys 
            100                 105                 110         


Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met Gly Lys Lys Lys Thr Leu 
        115                 120                 125             


Val Val Lys Lys Thr Leu Asn Pro Val Tyr Asn Glu Ile Leu Arg Tyr 
    130                 135                 140                 


Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln Lys Leu Asn Leu Ser Ile 
145                 150                 155                 160 


Trp His Arg Asp Thr Phe Lys Arg Asn Ser Phe Leu Gly Glu Val Glu 
                165                 170                 175     


Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn Lys Gln Asn Lys Gln Leu 
            180                 185                 190         


Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala Pro Val Ala Leu Glu Ala 
        195                 200                 205             


Glu Asn Arg Gly Glu Met Lys Leu Ala Leu Gln Tyr Val Pro Glu Pro 
    210                 215                 220                 


Val Pro Gly Lys Lys Leu Pro Thr Thr Gly Glu Val His Ile Trp Val 
225                 230                 235                 240 


Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg Gly Ser His Leu Asn Ser 
                245                 250                 255     


Phe Val Lys Cys Thr Ile Leu Pro Asp Thr Ser Arg Lys Ser Arg Gln 
            260                 265                 270         


Lys Thr Arg Ala Val Gly Lys Thr Thr Asn Pro Ile Phe Asn His Thr 
        275                 280                 285             


Met Val Tyr Asp Gly Phe Arg Pro Glu Asp Leu Met Glu Ala Cys Val 
    290                 295                 300                 


Glu Leu Thr Val Trp Asp His Tyr Lys Leu Thr Asn Gln Phe Leu Gly 
305                 310                 315                 320 


Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys Ser Tyr Gly Thr Glu Val 
                325                 330                 335     


Asp Trp Met Asp Ser Thr Ser Glu Glu Val Ala Leu Trp Glu Lys Met 
            340                 345                 350         


Val Asn Ser Pro Asn Thr Trp Ile Glu Ala Thr Leu Pro Leu Arg Met 
        355                 360                 365             


Leu Leu Ile Ala Lys Ile Ser Lys 
    370                 375     


<210>  1285
<211>  2407
<212>  DNA
<213>  Homosapiens

<400>  1285
gtttttaaaa ttaactttgt tttgtatttg gttcaactcc ttgctagttc tctctctata     60

taatttataa aaactgcatg ttgctaatct catgatcctg tgcatgtgga ctactctgcc    120

tttaactttt ttacaaaaac atgtttgttc atagattaaa taaaagtatg ttttcaactt    180

aatgtctaat gttttctgac aattgtaaga ataattttga aatggaaatg ctgctgttta    240

gtttccacag tgcctacaca acctgataat ccattttctc accctgacaa actcaaaagg    300

atgagcaagt ctgttccagc atttctccaa gatgagagtg atgacagaga aacagataca    360

gcatcagaaa gcagttacca gctcagcaga cacaagaaga gcccgagctc tttaaccaat    420

cttagcagct cctctggcat gacgtccttg tcttctgtga gtggcagtgt gatgagtgtt    480

tatagtggag actttggcaa tctggaagtt aaaggaaata ttcagtttgc aattgaatat    540

gtggagtcac tgaaggagtt gcatgttttt gtggcccagt gtaaggactt agcagcagcg    600

gatgtaaaaa aacagcgttc agacccatat gtaaaggcct atttgctacc agacaaaggc    660

aaaatgggca agaagaaaac actcgtagtg aagaaaacct tgaatcctgt gtataacgaa    720

atactgcggt ataaaattga aaaacaaatc ttaaagacac agaaattgaa cctgtccatt    780

tggcatcggg atacatttaa gcgcaatagt ttcctagggg aggtggaact tgatttggaa    840

acatgggact gggataacaa acagaataaa caattgagat ggtaccctct gaagcggaag    900

acagcaccag ttgcccttga agcagaaaac agaggtgaaa tgaaactagc tctccagtat    960

gtcccagagc cagtccctgg taaaaagctt cctacaactg gagaagtgca catctgggtg   1020

aaggaatgcc ttgatctacc actgctaagg ggaagtcatc taaattcttt tgttaaatgt   1080

accatccttc cagatacaag taggaaaagt cgccagaaga caagagctgt agggaaaacc   1140

accaacccta tcttcaacca cactatggtg tatgatgggt tcaggcctga agatctgatg   1200

gaagcctgtg tagagcttac tgtctgggac cattacaaat taaccaacca atttttggga   1260

ggtcttcgta ttggctttgg aacaggtaaa agttatggga ctgaagtgga ctggatggac   1320

tctacttcag aggaagttgc tctctgggag aagatggtaa actcccccaa tacttggatt   1380

gaagcaacac tgcctctcag aatgcttttg attgccaaga tttccaaatg agcccaaatt   1440

ccactggctc ctccactgaa aactactaaa ccggtggaat ctgatcttga aaatctgagt   1500

aggtggacaa atatcctcac tttctatcta ttgcacctaa ggaatactac acagcatgta   1560

aaagtcaatc tgcatgtgct tctttgatta caaggcccaa gggatttaaa tataacaaaa   1620

tgtgtaattt gtgactctaa tattaaataa gatatttgaa caagctagga aaattgaatt   1680

tctgctgctg cttcaaagaa aaagctgccc cagagcatta aacatggggt attgttaaga   1740

agcaaaatgt tcttgtttgc catcatgtgt ttcacaccac aattctgtgc cacagttaag   1800

agggtctggt acccttgcag gacctttgta ggttgtggga aaaagtcgca gaaagatact   1860

caaagtggag cagggaatgg agacagacat cagtgatgat aaaaaaaaaa atggacctta   1920

agaaactatt tactctgtaa tctctaataa aatatggaat tccatattag ggcaatgaga   1980

ctgaaactac tggtgttttt ctgccttgag aaaacaaaca gttaaaacaa gcctcaaatg   2040

tattttagtg ccacccactg gccataggta caattcagtt gttggcttgt tttgacttaa   2100

ttctaaaata ggtctcaagc ctgtattttt atgagtttat ttttttaaaa ccctgcatat   2160

atatgattgt ttttcttata actttactat atgaaagcag cataagagta gtcacaaaca   2220

tgttttgcaa caaagtttta attagaatgt aagttgctca gttatactgt tcttcttatg   2280

tatgtaaaat tttcgtattt tgtaaaaacc cttagaataa attatcattt gatttaaatt   2340

gtattagaaa attagcgtga cttctcattt taaataaaat attttaggaa ttctaaacat   2400

ctaaaaa                                                             2407


<210>  1286
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  1286

Met Ser Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Ser Asp Asp Arg 
1               5                   10                  15      


Glu Thr Asp Thr Ala Ser Glu Ser Ser Tyr Gln Leu Ser Arg His Lys 
            20                  25                  30          


Lys Ser Pro Ser Ser Leu Thr Asn Leu Ser Ser Ser Ser Gly Met Thr 
        35                  40                  45              


Ser Leu Ser Ser Val Ser Gly Ser Val Met Ser Val Tyr Ser Gly Asp 
    50                  55                  60                  


Phe Gly Asn Leu Glu Val Lys Gly Asn Ile Gln Phe Ala Ile Glu Tyr 
65                  70                  75                  80  


Val Glu Ser Leu Lys Glu Leu His Val Phe Val Ala Gln Cys Lys Asp 
                85                  90                  95      


Leu Ala Ala Ala Asp Val Lys Lys Gln Arg Ser Asp Pro Tyr Val Lys 
            100                 105                 110         


Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met Gly Lys Lys Lys Thr Leu 
        115                 120                 125             


Val Val Lys Lys Thr Leu Asn Pro Val Tyr Asn Glu Ile Leu Arg Tyr 
    130                 135                 140                 


Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln Lys Leu Asn Leu Ser Ile 
145                 150                 155                 160 


Trp His Arg Asp Thr Phe Lys Arg Asn Ser Phe Leu Gly Glu Val Glu 
                165                 170                 175     


Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn Lys Gln Asn Lys Gln Leu 
            180                 185                 190         


Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala Pro Val Ala Leu Glu Ala 
        195                 200                 205             


Glu Asn Arg Gly Glu Met Lys Leu Ala Leu Gln Tyr Val Pro Glu Pro 
    210                 215                 220                 


Val Pro Gly Lys Lys Leu Pro Thr Thr Gly Glu Val His Ile Trp Val 
225                 230                 235                 240 


Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg Gly Ser His Leu Asn Ser 
                245                 250                 255     


Phe Val Lys Cys Thr Ile Leu Pro Asp Thr Ser Arg Lys Ser Arg Gln 
            260                 265                 270         


Lys Thr Arg Ala Val Gly Lys Thr Thr Asn Pro Ile Phe Asn His Thr 
        275                 280                 285             


Met Val Tyr Asp Gly Phe Arg Pro Glu Asp Leu Met Glu Ala Cys Val 
    290                 295                 300                 


Glu Leu Thr Val Trp Asp His Tyr Lys Leu Thr Asn Gln Phe Leu Gly 
305                 310                 315                 320 


Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys Ser Tyr Gly Thr Glu Val 
                325                 330                 335     


Asp Trp Met Asp Ser Thr Ser Glu Glu Val Ala Leu Trp Glu Lys Met 
            340                 345                 350         


Val Asn Ser Pro Asn Thr Trp Ile Glu Ala Thr Leu Pro Leu Arg Met 
        355                 360                 365             


Leu Leu Ile Ala Lys Ile Ser Lys 
    370                 375     


<210>  1287
<211>  3985
<212>  DNA
<213>  Homosapiens

<400>  1287
aacaagcgac ctgtttggca aggaatacag catccttctg agagcctctt ctcgacacta     60

tcccacagac caggacttcc tcatgggaaa gagcacttag gatcttgcta tcagctgccc    120

taaacttttg ctgagccaaa ataagacttt gatgcagaac tgaacaagat atttcatttt    180

tgtgtgtttt aatcttcctg gttgcagtct tagttgttca gccctgagaa ttttgagcca    240

catttgttgc tattattttt gcatgcactt ttcaaaatga ttgacttaag cttcctgact    300

gaagaggaac aagaggccat catgaaggtt ttgcagcggg atgctgctct gaagagggcc    360

gaagaagaga gagtcagaca tttgcctgaa aaaattaagg atgaccagca gctgaagaat    420

atgagtggcc aatggtttta tgaagccaag gcaaaaaggc acagggacaa aatccatggc    480

gcagatatca tcagagcatc tatgagaaag aagaggcccc agatagcagc tgagcagagt    540

aaagacagag aaaatggggc aaaggaaagc tgggtgaata atgtcaacaa agatgctttc    600

cttcctccag agctggctgg cgttgtagaa gagccagaag aagatgcagc accagcaagc    660

ccgagttcca gtgtggtaaa tccagcttcc agtgtgattg atatgtccca ggaaaacaca    720

aggaaaccaa atgtgtctcc agagaagagg aagaatccgt ttaatagctc caagttgcca    780

gaaggtcact catcacaaca aactaaaaat gaacagtcaa aaaatggaag aactggttta    840

tttcagactt caaaagagga tgaattgtca gagtcaaaag aaaagtcaac tgtcgcagat    900

acttcaatcc aaaagttaga gaaatcaaag cagactttgc caggcctttc aaatgggtcc    960

caaatcaagg ctccaatccc caaagccagg aagatgatct acaaatcaac tgatttaaac   1020

aaagatgata accagtcttt tcctagacaa aggacagact ccctgaaagc gagaggggct   1080

ccgagaggga tcctcaagcg caactccagt tccagtagca cagactcaga aacccttcgt   1140

tataatcaca actttgaacc caaaagcaaa attgtgtcac ctggcctaac catccatgag   1200

agaatttctg agaaggagca ttctttagaa gacaactctt ccccaaactc cctggagcca   1260

ttaaagcatg tgagattctc tgcagtgaag gatgagcttc cacagagtcc tgggctaatc   1320

catggtcggg aagtaggaga atttagtgtt ttagaatctg acagattgaa aaatggaatg   1380

gaagatgcag gggacacaga agagtttcag agtgacccta agccttctca atacagaaag   1440

ccttcgcttt ttcatcaatc aacctcaagc ccatatgtat caaaaagtga aacacatcag   1500

ccaatgactt ctggttcttt tccaattaat gggctgcatt ctcattcaga agttttaact   1560

gcaagaccac agtctatgga gaattcacca accatcaatg aacccaaaga taaatcatca   1620

gaattaacaa ggcttgaatc tgtattaccc agaagccctg ctgatgaact gtctcattgt   1680

gttgagcctg agccatctca ggtgccaggt ggcagttcta gagaccgtca gcaaggttca   1740

gaagaagaac ccagtcctgt tttgaaaact ttggaaagga gtgccgctag gaaaatgcct   1800

tccaaaagtc tagaagacat ttcatcagat tcatcaaatc aagcaaaagt agataatcag   1860

ccagaagaat tagtgcgtag tgctgaagat gatgagaaac cagatcagaa gccagttaca   1920

aatgaatgcg taccaagaat ttccacagtg cctacacaac ctgataatcc attttctcac   1980

cctgacaaac tcaaaaggat gagcaagtct gttccagcat ttctccaaga tgaggtgagt   2040

ggcagtgtga tgagtgttta tagtggagac tttggcaatc tggaagttaa aggaaatatt   2100

cagtttgcaa ttgaatatgt ggagtcactg aaggagttgc atgtttttgt ggcccagtgt   2160

aaggacttag cagcagcgga tgtaaaaaaa cagcgttcag acccatatgt aaaggcctat   2220

ttgctaccag acaaaggcaa aatgggcaag aagaaaacac tcgtagtgaa gaaaaccttg   2280

aatcctgtgt ataacgaaat actgcggtat aaaattgaaa aacaaatctt aaagacacag   2340

aaattgaacc tgtccatttg gcatcgggat acatttaagc gcaatagttt cctaggggag   2400

gtggaacttg atttggaaac atgggactgg gataacaaac agaataaaca attgagatgg   2460

taccctctga agcggaagac agcaccagtt gcccttgaag cagaaaacag aggtgaaatg   2520

aaactagctc tccagtatgt cccagagcca gtccctggta aaaagcttcc tacaactgga   2580

gaagtgcaca tctgggtgaa ggaatgcctt gatctaccac tgctaagggg aagtcatcta   2640

aattcttttg ttaaatgtac catccttcca gatacaagta ggaaaagtcg ccagaagaca   2700

agagctgtag ggaaaaccac caaccctatc ttcaaccaca ctatggtgta tgatgggttc   2760

aggcctgaag atctgatgga agcctgtgta gagcttactg tctgggacca ttacaaatta   2820

accaaccaat ttttgggagg tcttcgtatt ggctttggaa caggtaaaag ttatgggact   2880

gaagtggact ggatggactc tacttcagag gaagttgctc tctgggagaa gatggtaaac   2940

tcccccaata cttggattga agcaacactg cctctcagaa tgcttttgat tgccaagatt   3000

tccaaatgag cccaaattcc actggctcct ccactgaaaa ctactaaacc ggtggaatct   3060

gatcttgaaa atctgagtag gtggacaaat atcctcactt tctatctatt gcacctaagg   3120

aatactacac agcatgtaaa agtcaatctg catgtgcttc tttgattaca aggcccaagg   3180

gatttaaata taacaaaatg tgtaatttgt gactctaata ttaaataaga tatttgaaca   3240

agctaggaaa attgaatttc tgctgctgct tcaaagaaaa agctgcccca gagcattaaa   3300

catggggtat tgttaagaag caaaatgttc ttgtttgcca tcatgtgttt cacaccacaa   3360

ttctgtgcca cagttaagag ggtctggtac ccttgcagga cctttgtagg ttgtgggaaa   3420

aagtcgcaga aagatactca aagtggagca gggaatggag acagacatca gtgatgataa   3480

aaaaaaaaat ggaccttaag aaactattta ctctgtaatc tctaataaaa tatggaattc   3540

catattaggg caatgagact gaaactactg gtgtttttct gccttgagaa aacaaacagt   3600

taaaacaagc ctcaaatgta ttttagtgcc acccactggc cataggtaca attcagttgt   3660

tggcttgttt tgacttaatt ctaaaatagg tctcaagcct gtatttttat gagtttattt   3720

ttttaaaacc ctgcatatat atgattgttt ttcttataac tttactatat gaaagcagca   3780

taagagtagt cacaaacatg ttttgcaaca aagttttaat tagaatgtaa gttgctcagt   3840

tatactgttc ttcttatgta tgtaaaattt tcgtattttg taaaaaccct tagaataaat   3900

tatcatttga tttaaattgt attagaaaat tagcgtgact tctcatttta aataaaatat   3960

tttaggaatt ctaaacatct aaaaa                                         3985


<210>  1288
<211>  910
<212>  PRT
<213>  Homosapiens

<400>  1288

Met Ile Asp Leu Ser Phe Leu Thr Glu Glu Glu Gln Glu Ala Ile Met 
1               5                   10                  15      


Lys Val Leu Gln Arg Asp Ala Ala Leu Lys Arg Ala Glu Glu Glu Arg 
            20                  25                  30          


Val Arg His Leu Pro Glu Lys Ile Lys Asp Asp Gln Gln Leu Lys Asn 
        35                  40                  45              


Met Ser Gly Gln Trp Phe Tyr Glu Ala Lys Ala Lys Arg His Arg Asp 
    50                  55                  60                  


Lys Ile His Gly Ala Asp Ile Ile Arg Ala Ser Met Arg Lys Lys Arg 
65                  70                  75                  80  


Pro Gln Ile Ala Ala Glu Gln Ser Lys Asp Arg Glu Asn Gly Ala Lys 
                85                  90                  95      


Glu Ser Trp Val Asn Asn Val Asn Lys Asp Ala Phe Leu Pro Pro Glu 
            100                 105                 110         


Leu Ala Gly Val Val Glu Glu Pro Glu Glu Asp Ala Ala Pro Ala Ser 
        115                 120                 125             


Pro Ser Ser Ser Val Val Asn Pro Ala Ser Ser Val Ile Asp Met Ser 
    130                 135                 140                 


Gln Glu Asn Thr Arg Lys Pro Asn Val Ser Pro Glu Lys Arg Lys Asn 
145                 150                 155                 160 


Pro Phe Asn Ser Ser Lys Leu Pro Glu Gly His Ser Ser Gln Gln Thr 
                165                 170                 175     


Lys Asn Glu Gln Ser Lys Asn Gly Arg Thr Gly Leu Phe Gln Thr Ser 
            180                 185                 190         


Lys Glu Asp Glu Leu Ser Glu Ser Lys Glu Lys Ser Thr Val Ala Asp 
        195                 200                 205             


Thr Ser Ile Gln Lys Leu Glu Lys Ser Lys Gln Thr Leu Pro Gly Leu 
    210                 215                 220                 


Ser Asn Gly Ser Gln Ile Lys Ala Pro Ile Pro Lys Ala Arg Lys Met 
225                 230                 235                 240 


Ile Tyr Lys Ser Thr Asp Leu Asn Lys Asp Asp Asn Gln Ser Phe Pro 
                245                 250                 255     


Arg Gln Arg Thr Asp Ser Leu Lys Ala Arg Gly Ala Pro Arg Gly Ile 
            260                 265                 270         


Leu Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg 
        275                 280                 285             


Tyr Asn His Asn Phe Glu Pro Lys Ser Lys Ile Val Ser Pro Gly Leu 
    290                 295                 300                 


Thr Ile His Glu Arg Ile Ser Glu Lys Glu His Ser Leu Glu Asp Asn 
305                 310                 315                 320 


Ser Ser Pro Asn Ser Leu Glu Pro Leu Lys His Val Arg Phe Ser Ala 
                325                 330                 335     


Val Lys Asp Glu Leu Pro Gln Ser Pro Gly Leu Ile His Gly Arg Glu 
            340                 345                 350         


Val Gly Glu Phe Ser Val Leu Glu Ser Asp Arg Leu Lys Asn Gly Met 
        355                 360                 365             


Glu Asp Ala Gly Asp Thr Glu Glu Phe Gln Ser Asp Pro Lys Pro Ser 
    370                 375                 380                 


Gln Tyr Arg Lys Pro Ser Leu Phe His Gln Ser Thr Ser Ser Pro Tyr 
385                 390                 395                 400 


Val Ser Lys Ser Glu Thr His Gln Pro Met Thr Ser Gly Ser Phe Pro 
                405                 410                 415     


Ile Asn Gly Leu His Ser His Ser Glu Val Leu Thr Ala Arg Pro Gln 
            420                 425                 430         


Ser Met Glu Asn Ser Pro Thr Ile Asn Glu Pro Lys Asp Lys Ser Ser 
        435                 440                 445             


Glu Leu Thr Arg Leu Glu Ser Val Leu Pro Arg Ser Pro Ala Asp Glu 
    450                 455                 460                 


Leu Ser His Cys Val Glu Pro Glu Pro Ser Gln Val Pro Gly Gly Ser 
465                 470                 475                 480 


Ser Arg Asp Arg Gln Gln Gly Ser Glu Glu Glu Pro Ser Pro Val Leu 
                485                 490                 495     


Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys Ser Leu 
            500                 505                 510         


Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp Asn Gln 
        515                 520                 525             


Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Asp Glu Lys Pro Asp Gln 
    530                 535                 540                 


Lys Pro Val Thr Asn Glu Cys Val Pro Arg Ile Ser Thr Val Pro Thr 
545                 550                 555                 560 


Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg Met Ser 
                565                 570                 575     


Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Val Ser Gly Ser Val Met 
            580                 585                 590         


Ser Val Tyr Ser Gly Asp Phe Gly Asn Leu Glu Val Lys Gly Asn Ile 
        595                 600                 605             


Gln Phe Ala Ile Glu Tyr Val Glu Ser Leu Lys Glu Leu His Val Phe 
    610                 615                 620                 


Val Ala Gln Cys Lys Asp Leu Ala Ala Ala Asp Val Lys Lys Gln Arg 
625                 630                 635                 640 


Ser Asp Pro Tyr Val Lys Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met 
                645                 650                 655     


Gly Lys Lys Lys Thr Leu Val Val Lys Lys Thr Leu Asn Pro Val Tyr 
            660                 665                 670         


Asn Glu Ile Leu Arg Tyr Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln 
        675                 680                 685             


Lys Leu Asn Leu Ser Ile Trp His Arg Asp Thr Phe Lys Arg Asn Ser 
    690                 695                 700                 


Phe Leu Gly Glu Val Glu Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn 
705                 710                 715                 720 


Lys Gln Asn Lys Gln Leu Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala 
                725                 730                 735     


Pro Val Ala Leu Glu Ala Glu Asn Arg Gly Glu Met Lys Leu Ala Leu 
            740                 745                 750         


Gln Tyr Val Pro Glu Pro Val Pro Gly Lys Lys Leu Pro Thr Thr Gly 
        755                 760                 765             


Glu Val His Ile Trp Val Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg 
    770                 775                 780                 


Gly Ser His Leu Asn Ser Phe Val Lys Cys Thr Ile Leu Pro Asp Thr 
785                 790                 795                 800 


Ser Arg Lys Ser Arg Gln Lys Thr Arg Ala Val Gly Lys Thr Thr Asn 
                805                 810                 815     


Pro Ile Phe Asn His Thr Met Val Tyr Asp Gly Phe Arg Pro Glu Asp 
            820                 825                 830         


Leu Met Glu Ala Cys Val Glu Leu Thr Val Trp Asp His Tyr Lys Leu 
        835                 840                 845             


Thr Asn Gln Phe Leu Gly Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys 
    850                 855                 860                 


Ser Tyr Gly Thr Glu Val Asp Trp Met Asp Ser Thr Ser Glu Glu Val 
865                 870                 875                 880 


Ala Leu Trp Glu Lys Met Val Asn Ser Pro Asn Thr Trp Ile Glu Ala 
                885                 890                 895     


Thr Leu Pro Leu Arg Met Leu Leu Ile Ala Lys Ile Ser Lys 
            900                 905                 910 


<210>  1289
<211>  4807
<212>  DNA
<213>  Homosapiens

<400>  1289
ctaaaagaaa gaatggatga acccaatgca gaacaggtct ataatccctc tcagtttgag     60

aatttgagaa agttttggga cttagaagct aattcaaaca gtaaggataa tgacaagaat    120

attaccacca caagccaaaa aaattctgca ccttttaata ggcagaaaca caaggaattc    180

agcgacatta aattatcagg taaaaatacc catgaagcag aggtgcttct aagcccaaaa    240

aaagttatgg caagagagga aatggagaaa ttaaattcaa agggcatact ccaggtgcta    300

ccagatgaaa tcacatttcc tttgagtcca cttagaaagt atacttatca gttgccagga    360

aatgagtcat caaaggaaaa tgtggaaaag aatacggaag ggattgttac tccagtgttt    420

aaggaagaaa aggattactc agaacaagag attcaagaat ccataataaa aaccaatgtt    480

ttgtctaaag actgcaaaga cacttttaat gacagcttgc agaaactgct ttcagaaacc    540

tcaacaccag caattcaacc ctctggtgga aaagttcatg gaaaacaagt gcttgaacca    600

agtgtttctg aaaataggac atggcctcaa aaaacagatt ttgctgatac tgaggaagaa    660

gtcaaaggac ctgagaagat cattaatgag catgttgaca aaacagtagt tcatccaaag    720

gttaaacgga actctttgac tgctagtcta gacaaactcc tgaaggaagc aactggaact    780

tcaccctctc ccttgcaagc caagttggcg cccgttatca ctggaaccaa ctctaagctg    840

gaagagggga gattttttgg aaaagggata gaacagagtc acaatacttc agctgataag    900

agagaaatac tagctccttt tccagtgaga gatgaaactt ttggaaatac agctctcctc    960

aagaaagctg aaagtggtga gtgccagcta agcacacaga atttgattca gatggctgca   1020

gaagattctc atccattgga tccaacttcc cagctttcca gaaagggttc ttttggggat   1080

gtggccagcc ctccccaaga tatgcttttt ccccaggatg ctcatcttgt tccccaggct   1140

agggtacacc cttctcaaac ggaaatttcg gagactgtag agaaagtcat tcttccaccc   1200

agacctgtat tgaatgatgt aagtgctgca ttacagaagc tgtgtggaga agtatggtta   1260

agttatccag ctggaaggga agtaggtcct ggagaagtga acccagaatt tcctgaagca   1320

gtacagccag tatgtagccc cctaaatcct ccaggagtga tatcaccatg ggctacgatg   1380

gacaccatag ttccagacag gaaggatttt tattcctcca atgtagttcc tgataaaact   1440

catgaagttg gatcttattt agctgcccaa atgtctccat cagaccagac gcttagctca   1500

tttgcttcca ttgttgctca atatggcaaa ggcctccctc aggaagtgga agaaattgtg   1560

agggaaacaa ttgttcaacc caaatcagag ttcctcgaat tcagtgctgg cttagaaaaa   1620

ctactgaagg aagaaactga aaccttcccc tcaaaatatg aaagtgatac agggaatctt   1680

tctccatcaa agttaatagg tagtacagag gagcccaggc gagccacttc tgaatgccat   1740

cctgaggaat taaaagaaac agtagaaaag gccgaggctc cgttaataac tgagagtgct   1800

tttgatgctg gttttgagaa acttcttaaa gaaataactg aagctcctcc ttatcagccc   1860

caggtgtcag tgagagaaga aactcacgag aaggagtcct cacagtcaga gcagaccagg   1920

ttcttgggga cagtgcccca tttttacagg gcagcctcac agacctctga aatgaaggat   1980

aaaagtaatg gtttggaatc tcaagtcaac caatgtgata aaatgttggg aggagacgca   2040

cttgtgactg atttattggt agatttttgt ggttccagaa gtggagttga gatccctaga   2100

accccacaac tttatgtggc tcatgaaata gggaccatta aaactgtaac ccccccagag   2160

gacagggaca gtgaaagtgg ggttgcaggg ggacaaggga ctcttcagga acctggcttt   2220

ggagaggctt ctgaagcaat tagtgtgtcc agaaataggc aacccattcc tctcctgatg   2280

aacaaagaaa actctacaaa aacaagtaaa gttgaattga ctctagcatc gccatatatg   2340

aaacaagaga aagaggaaga aaaagaaggt ttctctgagt ctgatttttc agatggaaac   2400

accagttcta atgcagagag ctggagaaat ccttccagtt cagaagaaga acccagtcct   2460

gttttgaaaa ctttggaaag gagtgccgct aggaaaatgc cttccaaaag tctagaagac   2520

atttcatcag attcatcaaa tcaagcaaaa gtagataatc agccagaaga attagtgcgt   2580

agtgctgaag atgatgagaa accagatcag aagccagtta caaatgaatg cgtaccaaga   2640

atttccacag tgcctacaca acctgataat ccattttctc accctgacaa actcaaaagg   2700

atgagcaagt ctgttccagc atttctccaa gatgagagtg atgacagaga aacagataca   2760

gcatcagaaa gcagttacca gctcagcaga cacaagaaga gcccgagctc tttaaccaat   2820

cttagcagct cctctggcat gacgtccttg tcttctgtga gtggcagtgt gatgagtgtt   2880

tatagtggag actttggcaa tctggaagtt aaaggaaata ttcagtttgc aattgaatat   2940

gtggagtcac tgaaggagtt gcatgttttt gtggcccagt gtaaggactt agcagcagcg   3000

gatgtaaaaa aacagcgttc agacccatat gtaaaggcct atttgctacc agacaaaggc   3060

aaaatgggca agaagaaaac actcgtagtg aagaaaacct tgaatcctgt gtataacgaa   3120

atactgcggt ataaaattga aaaacaaatc ttaaagacac agaaattgaa cctgtccatt   3180

tggcatcggg atacatttaa gcgcaatagt ttcctagggg aggtggaact tgatttggaa   3240

acatgggact gggataacaa acagaataaa caattgagat ggtaccctct gaagcggaag   3300

acagcaccag ttgcccttga agcagaaaac agaggtgaaa tgaaactagc tctccagtat   3360

gtcccagagc cagtccctgg taaaaagctt cctacaactg gagaagtgca catctgggtg   3420

aaggaatgcc ttgatctacc actgctaagg ggaagtcatc taaattcttt tgttaaatgt   3480

accatccttc cagatacaag taggaaaagt cgccagaaga caagagctgt agggaaaacc   3540

accaacccta tcttcaacca cactatggtg tatgatgggt tcaggcctga agatctgatg   3600

gaagcctgtg tagagcttac tgtctgggac cattacaaat taaccaacca atttttggga   3660

ggtcttcgta ttggctttgg aacaggtaaa agttatggga ctgaagtgga ctggatggac   3720

tctacttcag aggaagttgc tctctgggag aagatggtaa actcccccaa tacttggatt   3780

gaagcaacac tgcctctcag aatgcttttg attgccaaga tttccaaatg agcccaaatt   3840

ccactggctc ctccactgaa aactactaaa ccggtggaat ctgatcttga aaatctgagt   3900

aggtggacaa atatcctcac tttctatcta ttgcacctaa ggaatactac acagcatgta   3960

aaagtcaatc tgcatgtgct tctttgatta caaggcccaa gggatttaaa tataacaaaa   4020

tgtgtaattt gtgactctaa tattaaataa gatatttgaa caagctagga aaattgaatt   4080

tctgctgctg cttcaaagaa aaagctgccc cagagcatta aacatggggt attgttaaga   4140

agcaaaatgt tcttgtttgc catcatgtgt ttcacaccac aattctgtgc cacagttaag   4200

agggtctggt acccttgcag gacctttgta ggttgtggga aaaagtcgca gaaagatact   4260

caaagtggag cagggaatgg agacagacat cagtgatgat aaaaaaaaaa atggacctta   4320

agaaactatt tactctgtaa tctctaataa aatatggaat tccatattag ggcaatgaga   4380

ctgaaactac tggtgttttt ctgccttgag aaaacaaaca gttaaaacaa gcctcaaatg   4440

tattttagtg ccacccactg gccataggta caattcagtt gttggcttgt tttgacttaa   4500

ttctaaaata ggtctcaagc ctgtattttt atgagtttat ttttttaaaa ccctgcatat   4560

atatgattgt ttttcttata actttactat atgaaagcag cataagagta gtcacaaaca   4620

tgttttgcaa caaagtttta attagaatgt aagttgctca gttatactgt tcttcttatg   4680

tatgtaaaat tttcgtattt tgtaaaaacc cttagaataa attatcattt gatttaaatt   4740

gtattagaaa attagcgtga cttctcattt taaataaaat attttaggaa ttctaaacat   4800

ctaaaaa                                                             4807


<210>  1290
<211>  1272
<212>  PRT
<213>  Homosapiens

<400>  1290

Met Asp Glu Pro Asn Ala Glu Gln Val Tyr Asn Pro Ser Gln Phe Glu 
1               5                   10                  15      


Asn Leu Arg Lys Phe Trp Asp Leu Glu Ala Asn Ser Asn Ser Lys Asp 
            20                  25                  30          


Asn Asp Lys Asn Ile Thr Thr Thr Ser Gln Lys Asn Ser Ala Pro Phe 
        35                  40                  45              


Asn Arg Gln Lys His Lys Glu Phe Ser Asp Ile Lys Leu Ser Gly Lys 
    50                  55                  60                  


Asn Thr His Glu Ala Glu Val Leu Leu Ser Pro Lys Lys Val Met Ala 
65                  70                  75                  80  


Arg Glu Glu Met Glu Lys Leu Asn Ser Lys Gly Ile Leu Gln Val Leu 
                85                  90                  95      


Pro Asp Glu Ile Thr Phe Pro Leu Ser Pro Leu Arg Lys Tyr Thr Tyr 
            100                 105                 110         


Gln Leu Pro Gly Asn Glu Ser Ser Lys Glu Asn Val Glu Lys Asn Thr 
        115                 120                 125             


Glu Gly Ile Val Thr Pro Val Phe Lys Glu Glu Lys Asp Tyr Ser Glu 
    130                 135                 140                 


Gln Glu Ile Gln Glu Ser Ile Ile Lys Thr Asn Val Leu Ser Lys Asp 
145                 150                 155                 160 


Cys Lys Asp Thr Phe Asn Asp Ser Leu Gln Lys Leu Leu Ser Glu Thr 
                165                 170                 175     


Ser Thr Pro Ala Ile Gln Pro Ser Gly Gly Lys Val His Gly Lys Gln 
            180                 185                 190         


Val Leu Glu Pro Ser Val Ser Glu Asn Arg Thr Trp Pro Gln Lys Thr 
        195                 200                 205             


Asp Phe Ala Asp Thr Glu Glu Glu Val Lys Gly Pro Glu Lys Ile Ile 
    210                 215                 220                 


Asn Glu His Val Asp Lys Thr Val Val His Pro Lys Val Lys Arg Asn 
225                 230                 235                 240 


Ser Leu Thr Ala Ser Leu Asp Lys Leu Leu Lys Glu Ala Thr Gly Thr 
                245                 250                 255     


Ser Pro Ser Pro Leu Gln Ala Lys Leu Ala Pro Val Ile Thr Gly Thr 
            260                 265                 270         


Asn Ser Lys Leu Glu Glu Gly Arg Phe Phe Gly Lys Gly Ile Glu Gln 
        275                 280                 285             


Ser His Asn Thr Ser Ala Asp Lys Arg Glu Ile Leu Ala Pro Phe Pro 
    290                 295                 300                 


Val Arg Asp Glu Thr Phe Gly Asn Thr Ala Leu Leu Lys Lys Ala Glu 
305                 310                 315                 320 


Ser Gly Glu Cys Gln Leu Ser Thr Gln Asn Leu Ile Gln Met Ala Ala 
                325                 330                 335     


Glu Asp Ser His Pro Leu Asp Pro Thr Ser Gln Leu Ser Arg Lys Gly 
            340                 345                 350         


Ser Phe Gly Asp Val Ala Ser Pro Pro Gln Asp Met Leu Phe Pro Gln 
        355                 360                 365             


Asp Ala His Leu Val Pro Gln Ala Arg Val His Pro Ser Gln Thr Glu 
    370                 375                 380                 


Ile Ser Glu Thr Val Glu Lys Val Ile Leu Pro Pro Arg Pro Val Leu 
385                 390                 395                 400 


Asn Asp Val Ser Ala Ala Leu Gln Lys Leu Cys Gly Glu Val Trp Leu 
                405                 410                 415     


Ser Tyr Pro Ala Gly Arg Glu Val Gly Pro Gly Glu Val Asn Pro Glu 
            420                 425                 430         


Phe Pro Glu Ala Val Gln Pro Val Cys Ser Pro Leu Asn Pro Pro Gly 
        435                 440                 445             


Val Ile Ser Pro Trp Ala Thr Met Asp Thr Ile Val Pro Asp Arg Lys 
    450                 455                 460                 


Asp Phe Tyr Ser Ser Asn Val Val Pro Asp Lys Thr His Glu Val Gly 
465                 470                 475                 480 


Ser Tyr Leu Ala Ala Gln Met Ser Pro Ser Asp Gln Thr Leu Ser Ser 
                485                 490                 495     


Phe Ala Ser Ile Val Ala Gln Tyr Gly Lys Gly Leu Pro Gln Glu Val 
            500                 505                 510         


Glu Glu Ile Val Arg Glu Thr Ile Val Gln Pro Lys Ser Glu Phe Leu 
        515                 520                 525             


Glu Phe Ser Ala Gly Leu Glu Lys Leu Leu Lys Glu Glu Thr Glu Thr 
    530                 535                 540                 


Phe Pro Ser Lys Tyr Glu Ser Asp Thr Gly Asn Leu Ser Pro Ser Lys 
545                 550                 555                 560 


Leu Ile Gly Ser Thr Glu Glu Pro Arg Arg Ala Thr Ser Glu Cys His 
                565                 570                 575     


Pro Glu Glu Leu Lys Glu Thr Val Glu Lys Ala Glu Ala Pro Leu Ile 
            580                 585                 590         


Thr Glu Ser Ala Phe Asp Ala Gly Phe Glu Lys Leu Leu Lys Glu Ile 
        595                 600                 605             


Thr Glu Ala Pro Pro Tyr Gln Pro Gln Val Ser Val Arg Glu Glu Thr 
    610                 615                 620                 


His Glu Lys Glu Ser Ser Gln Ser Glu Gln Thr Arg Phe Leu Gly Thr 
625                 630                 635                 640 


Val Pro His Phe Tyr Arg Ala Ala Ser Gln Thr Ser Glu Met Lys Asp 
                645                 650                 655     


Lys Ser Asn Gly Leu Glu Ser Gln Val Asn Gln Cys Asp Lys Met Leu 
            660                 665                 670         


Gly Gly Asp Ala Leu Val Thr Asp Leu Leu Val Asp Phe Cys Gly Ser 
        675                 680                 685             


Arg Ser Gly Val Glu Ile Pro Arg Thr Pro Gln Leu Tyr Val Ala His 
    690                 695                 700                 


Glu Ile Gly Thr Ile Lys Thr Val Thr Pro Pro Glu Asp Arg Asp Ser 
705                 710                 715                 720 


Glu Ser Gly Val Ala Gly Gly Gln Gly Thr Leu Gln Glu Pro Gly Phe 
                725                 730                 735     


Gly Glu Ala Ser Glu Ala Ile Ser Val Ser Arg Asn Arg Gln Pro Ile 
            740                 745                 750         


Pro Leu Leu Met Asn Lys Glu Asn Ser Thr Lys Thr Ser Lys Val Glu 
        755                 760                 765             


Leu Thr Leu Ala Ser Pro Tyr Met Lys Gln Glu Lys Glu Glu Glu Lys 
    770                 775                 780                 


Glu Gly Phe Ser Glu Ser Asp Phe Ser Asp Gly Asn Thr Ser Ser Asn 
785                 790                 795                 800 


Ala Glu Ser Trp Arg Asn Pro Ser Ser Ser Glu Glu Glu Pro Ser Pro 
                805                 810                 815     


Val Leu Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys 
            820                 825                 830         


Ser Leu Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp 
        835                 840                 845             


Asn Gln Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Asp Glu Lys Pro 
    850                 855                 860                 


Asp Gln Lys Pro Val Thr Asn Glu Cys Val Pro Arg Ile Ser Thr Val 
865                 870                 875                 880 


Pro Thr Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg 
                885                 890                 895     


Met Ser Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Ser Asp Asp Arg 
            900                 905                 910         


Glu Thr Asp Thr Ala Ser Glu Ser Ser Tyr Gln Leu Ser Arg His Lys 
        915                 920                 925             


Lys Ser Pro Ser Ser Leu Thr Asn Leu Ser Ser Ser Ser Gly Met Thr 
    930                 935                 940                 


Ser Leu Ser Ser Val Ser Gly Ser Val Met Ser Val Tyr Ser Gly Asp 
945                 950                 955                 960 


Phe Gly Asn Leu Glu Val Lys Gly Asn Ile Gln Phe Ala Ile Glu Tyr 
                965                 970                 975     


Val Glu Ser Leu Lys Glu Leu His Val Phe Val Ala Gln Cys Lys Asp 
            980                 985                 990         


Leu Ala Ala Ala Asp Val Lys Lys  Gln Arg Ser Asp Pro  Tyr Val Lys 
        995                 1000                 1005             


Ala Tyr  Leu Leu Pro Asp Lys  Gly Lys Met Gly Lys  Lys Lys Thr 
    1010                 1015                 1020             


Leu Val  Val Lys Lys Thr Leu  Asn Pro Val Tyr Asn  Glu Ile Leu 
    1025                 1030                 1035             


Arg Tyr  Lys Ile Glu Lys Gln  Ile Leu Lys Thr Gln  Lys Leu Asn 
    1040                 1045                 1050             


Leu Ser  Ile Trp His Arg Asp  Thr Phe Lys Arg Asn  Ser Phe Leu 
    1055                 1060                 1065             


Gly Glu  Val Glu Leu Asp Leu  Glu Thr Trp Asp Trp  Asp Asn Lys 
    1070                 1075                 1080             


Gln Asn  Lys Gln Leu Arg Trp  Tyr Pro Leu Lys Arg  Lys Thr Ala 
    1085                 1090                 1095             


Pro Val  Ala Leu Glu Ala Glu  Asn Arg Gly Glu Met  Lys Leu Ala 
    1100                 1105                 1110             


Leu Gln  Tyr Val Pro Glu Pro  Val Pro Gly Lys Lys  Leu Pro Thr 
    1115                 1120                 1125             


Thr Gly  Glu Val His Ile Trp  Val Lys Glu Cys Leu  Asp Leu Pro 
    1130                 1135                 1140             


Leu Leu  Arg Gly Ser His Leu  Asn Ser Phe Val Lys  Cys Thr Ile 
    1145                 1150                 1155             


Leu Pro  Asp Thr Ser Arg Lys  Ser Arg Gln Lys Thr  Arg Ala Val 
    1160                 1165                 1170             


Gly Lys  Thr Thr Asn Pro Ile  Phe Asn His Thr Met  Val Tyr Asp 
    1175                 1180                 1185             


Gly Phe  Arg Pro Glu Asp Leu  Met Glu Ala Cys Val  Glu Leu Thr 
    1190                 1195                 1200             


Val Trp  Asp His Tyr Lys Leu  Thr Asn Gln Phe Leu  Gly Gly Leu 
    1205                 1210                 1215             


Arg Ile  Gly Phe Gly Thr Gly  Lys Ser Tyr Gly Thr  Glu Val Asp 
    1220                 1225                 1230             


Trp Met  Asp Ser Thr Ser Glu  Glu Val Ala Leu Trp  Glu Lys Met 
    1235                 1240                 1245             


Val Asn  Ser Pro Asn Thr Trp  Ile Glu Ala Thr Leu  Pro Leu Arg 
    1250                 1255                 1260             


Met Leu  Leu Ile Ala Lys Ile  Ser Lys 
    1265                 1270         


<210>  1291
<211>  2450
<212>  DNA
<213>  Homosapiens

<400>  1291
acagaagaat agagaggctg ttgcagcccc gtgctttctc ctgctgctgg ccgattgctt     60

gctctgaact aaccctctaa cccttgggag tctgtgtgca gcagtgatgt gagctgcatc    120

cgggctgaaa tgggagctcc cgctatggca ctggctcaag gagctaatct aaagagaaag    180

tattttgggg aagacatctt ggttgcaccc ctcattgcat cttgactaat tgcttccaac    240

tccgggggct tccagggaca atctcattgt tcttttctct ccaagggtca gccatgttaa    300

ccatttgtta atttcttctg aacagatcaa gcaaaagtag ataatcagcc agaagaatta    360

gtgcgtagtg ctgaagatga gtgatgacag agaaacagat acagcatcag aaagcagtta    420

ccagctcagc agacacaaga agagcccgag ctctttaacc aatcttagca gctcctctgg    480

catgacgtcc ttgtcttctg tgagtggcag tgtgatgagt gtttatagtg gagactttgg    540

caatctggaa gttaaaggaa atattcagtt tgcaattgaa tatgtggagt cactgaagga    600

gttgcatgtt tttgtggccc agtgtaagga cttagcagca gcggatgtaa aaaaacagcg    660

ttcagaccca tatgtaaagg cctatttgct accagacaaa ggcaaaatgg gcaagaagaa    720

aacactcgta gtgaagaaaa ccttgaatcc tgtgtataac gaaatactgc ggtataaaat    780

tgaaaaacaa atcttaaaga cacagaaatt gaacctgtcc atttggcatc gggatacatt    840

taagcgcaat agtttcctag gggaggtgga acttgatttg gaaacatggg actgggataa    900

caaacagaat aaacaattga gatggtaccc tctgaagcgg aagacagcac cagttgccct    960

tgaagcagaa aacagaggtg aaatgaaact agctctccag tatgtcccag agccagtccc   1020

tggtaaaaag cttcctacaa ctggagaagt gcacatctgg gtgaaggaat gccttgatct   1080

accactgcta aggggaagtc atctaaattc ttttgttaaa tgtaccatcc ttccagatac   1140

aagtaggaaa agtcgccaga agacaagagc tgtagggaaa accaccaacc ctatcttcaa   1200

ccacactatg gtgtatgatg ggttcaggcc tgaagatctg atggaagcct gtgtagagct   1260

tactgtctgg gaccattaca aattaaccaa ccaatttttg ggaggtcttc gtattggctt   1320

tggaacaggt aaaagttatg ggactgaagt ggactggatg gactctactt cagaggaagt   1380

tgctctctgg gagaagatgg taaactcccc caatacttgg attgaagcaa cactgcctct   1440

cagaatgctt ttgattgcca agatttccaa atgagcccaa attccactgg ctcctccact   1500

gaaaactact aaaccggtgg aatctgatct tgaaaatctg agtaggtgga caaatatcct   1560

cactttctat ctattgcacc taaggaatac tacacagcat gtaaaagtca atctgcatgt   1620

gcttctttga ttacaaggcc caagggattt aaatataaca aaatgtgtaa tttgtgactc   1680

taatattaaa taagatattt gaacaagcta ggaaaattga atttctgctg ctgcttcaaa   1740

gaaaaagctg ccccagagca ttaaacatgg ggtattgtta agaagcaaaa tgttcttgtt   1800

tgccatcatg tgtttcacac cacaattctg tgccacagtt aagagggtct ggtacccttg   1860

caggaccttt gtaggttgtg ggaaaaagtc gcagaaagat actcaaagtg gagcagggaa   1920

tggagacaga catcagtgat gataaaaaaa aaaatggacc ttaagaaact atttactctg   1980

taatctctaa taaaatatgg aattccatat tagggcaatg agactgaaac tactggtgtt   2040

tttctgcctt gagaaaacaa acagttaaaa caagcctcaa atgtatttta gtgccaccca   2100

ctggccatag gtacaattca gttgttggct tgttttgact taattctaaa ataggtctca   2160

agcctgtatt tttatgagtt tattttttta aaaccctgca tatatatgat tgtttttctt   2220

ataactttac tatatgaaag cagcataaga gtagtcacaa acatgttttg caacaaagtt   2280

ttaattagaa tgtaagttgc tcagttatac tgttcttctt atgtatgtaa aattttcgta   2340

ttttgtaaaa acccttagaa taaattatca tttgatttaa attgtattag aaaattagcg   2400

tgacttctca ttttaaataa aatattttag gaattctaaa catctaaaaa              2450


<210>  1292
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  1292

Met Ser Asp Asp Arg Glu Thr Asp Thr Ala Ser Glu Ser Ser Tyr Gln 
1               5                   10                  15      


Leu Ser Arg His Lys Lys Ser Pro Ser Ser Leu Thr Asn Leu Ser Ser 
            20                  25                  30          


Ser Ser Gly Met Thr Ser Leu Ser Ser Val Ser Gly Ser Val Met Ser 
        35                  40                  45              


Val Tyr Ser Gly Asp Phe Gly Asn Leu Glu Val Lys Gly Asn Ile Gln 
    50                  55                  60                  


Phe Ala Ile Glu Tyr Val Glu Ser Leu Lys Glu Leu His Val Phe Val 
65                  70                  75                  80  


Ala Gln Cys Lys Asp Leu Ala Ala Ala Asp Val Lys Lys Gln Arg Ser 
                85                  90                  95      


Asp Pro Tyr Val Lys Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met Gly 
            100                 105                 110         


Lys Lys Lys Thr Leu Val Val Lys Lys Thr Leu Asn Pro Val Tyr Asn 
        115                 120                 125             


Glu Ile Leu Arg Tyr Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln Lys 
    130                 135                 140                 


Leu Asn Leu Ser Ile Trp His Arg Asp Thr Phe Lys Arg Asn Ser Phe 
145                 150                 155                 160 


Leu Gly Glu Val Glu Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn Lys 
                165                 170                 175     


Gln Asn Lys Gln Leu Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala Pro 
            180                 185                 190         


Val Ala Leu Glu Ala Glu Asn Arg Gly Glu Met Lys Leu Ala Leu Gln 
        195                 200                 205             


Tyr Val Pro Glu Pro Val Pro Gly Lys Lys Leu Pro Thr Thr Gly Glu 
    210                 215                 220                 


Val His Ile Trp Val Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg Gly 
225                 230                 235                 240 


Ser His Leu Asn Ser Phe Val Lys Cys Thr Ile Leu Pro Asp Thr Ser 
                245                 250                 255     


Arg Lys Ser Arg Gln Lys Thr Arg Ala Val Gly Lys Thr Thr Asn Pro 
            260                 265                 270         


Ile Phe Asn His Thr Met Val Tyr Asp Gly Phe Arg Pro Glu Asp Leu 
        275                 280                 285             


Met Glu Ala Cys Val Glu Leu Thr Val Trp Asp His Tyr Lys Leu Thr 
    290                 295                 300                 


Asn Gln Phe Leu Gly Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys Ser 
305                 310                 315                 320 


Tyr Gly Thr Glu Val Asp Trp Met Asp Ser Thr Ser Glu Glu Val Ala 
                325                 330                 335     


Leu Trp Glu Lys Met Val Asn Ser Pro Asn Thr Trp Ile Glu Ala Thr 
            340                 345                 350         


Leu Pro Leu Arg Met Leu Leu Ile Ala Lys Ile Ser Lys 
        355                 360                 365 


<210>  1293
<211>  2346
<212>  DNA
<213>  Homosapiens

<400>  1293
aaaatgcagg gcgcagcagc cgctgcagtg gagccggtag gcctggccgg cgggctgaaa     60

ggaagtgcga gctgtccgcc cagggccggg tatccgcccc tgcaggctgt ggaggggatg    120

tcaggagact ggctggcctc ttttcttggc ccccgactcc ttccagtctg acactgaaga    180

ctttataagc ttccccccga ccaccctcca cgggctccac tctccacggg cctgggcttg    240

cgccgcttcg agatcagcct gggggtcgcg ccctcctggt cttgtccacg aagcgccgtt    300

cttgggccgt taggagctgc tgggaagggc tctgataggc ccactcctct tctccaccca    360

ggagatgaga aggagggcag gcctttttaa tctgatcaga atgttaaccc atctctccgc    420

cttgcggtag aacccctgga tacattattt gccctctcga aaggcaggct ctgaatttga    480

ttcaggtata tttcttcata gctaaccagc acaatggaaa actcagggaa agcaaataaa    540

aaggatacac atgacgggcc accaaaagaa attaaactgc ctaccagtga agcacttcta    600

gactatcaat gtcaaataaa ggaagatgcc gtggagcaat tcatgtttca aataaagaca    660

cttaggaaaa agaaccaaaa atatcatgaa agaaatagcc gcttaaaaga agaacagatt    720

tggcacatac ggcatctact aaaggaactg agtgaagaga aggcagaggg attgccagtt    780

gtaacaagag aggatgttga agaagcgatg aaggaaaaat ggaagtttga aagagaccag    840

gaaaaaaact tgagagatat gcgcatgcaa ataagtaatg ctgagaaact atttcttgag    900

aaactcagtg aaaaggaata ttgggaggag tacaagaatg tagggagtga acgacatgct    960

aaactcatta cctccttaca aaatgacatc aacacagtta aagagaatgc agagaaaatg   1020

tcagaacact ataaaatcac tctggaagat actagaaaga aaataatcaa ggaaactttg   1080

ttgcaactgg accaaaagaa ggaatgggcc acacagaatg ctgtaaagct cattgacaag   1140

ggcagttatc tagagatctg ggagaatgac tggctcaaaa aagaggttgc aattcacagg   1200

aaggaagttg aagaattaaa aaatgctatt catgaactgg aagcagaaaa tttggtgctt   1260

attgatcaac tatccaactg tagacttgtg gatctcaaga tacccaggta tccagtgcta   1320

cattcctgtc ccacctctaa tcctcgtcat ctgctgctgc tgcctttgga atcatgtcta   1380

atctctgcca ggcgttgctg gcgactatat cttacccaag ctgctggact agaagtgcca   1440

cctgaagaaa tgtctttgga attgccagaa acacatatag aagagaagtc agaattgcaa   1500

cccacagaag tagaaagtag agacttgatg tcctcatcag atgagagcac tatcttacat   1560

cttagtcatg aaaatagcat cgaagatctc cagtatgtga agatagataa agaggaaaac   1620

tcaggcacag agtttgggga cactgatatg aagtacttac tatatgagga tgagaaggat   1680

ttcaaggatt atgtaaactt gggccccctg ggagtgaagc ttatgagtgt ggagagcaag   1740

aaaatgccca ttcattttca agagaaggaa attccagtca aactctataa agatgtcagg   1800

agcccagaaa gccacatcac atataagatg atgaagtctt ttctctaaga cggaaagctg   1860

caaaggaaac acaacttttc cttataaatg ttctttggga actgaagtat atccgttgcc   1920

cattttactt acactttggc tcatttttaa accagctgtt atttctaaag gtcatattta   1980

catttaaaat caaaggtatt cagctattca tttacttgca tggtatgagt gaccaaaacg   2040

gaagcacgct ttgtatttct acactgaagt attcagaagc atgacagtgg gttcaaggta   2100

gtctctgagg ttccttttca cacacaaaaa attcactgat taatctgtga ttccagtatg   2160

aaatagttcc attagaaatg tttctaagaa aaacttagaa gtttgcatag cattgtctac   2220

acatctttcc ctctgaggat gctcaatgtg atagacagcc agtctataat gcaagccaat   2280

tctccgtagt ttaaccctgt gtattagtct gttctcatgc tgctaataaa gacataattg   2340

aaactg                                                              2346


<210>  1294
<211>  444
<212>  PRT
<213>  Homosapiens

<400>  1294

Met Glu Asn Ser Gly Lys Ala Asn Lys Lys Asp Thr His Asp Gly Pro 
1               5                   10                  15      


Pro Lys Glu Ile Lys Leu Pro Thr Ser Glu Ala Leu Leu Asp Tyr Gln 
            20                  25                  30          


Cys Gln Ile Lys Glu Asp Ala Val Glu Gln Phe Met Phe Gln Ile Lys 
        35                  40                  45              


Thr Leu Arg Lys Lys Asn Gln Lys Tyr His Glu Arg Asn Ser Arg Leu 
    50                  55                  60                  


Lys Glu Glu Gln Ile Trp His Ile Arg His Leu Leu Lys Glu Leu Ser 
65                  70                  75                  80  


Glu Glu Lys Ala Glu Gly Leu Pro Val Val Thr Arg Glu Asp Val Glu 
                85                  90                  95      


Glu Ala Met Lys Glu Lys Trp Lys Phe Glu Arg Asp Gln Glu Lys Asn 
            100                 105                 110         


Leu Arg Asp Met Arg Met Gln Ile Ser Asn Ala Glu Lys Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Ser Glu Lys Glu Tyr Trp Glu Glu Tyr Lys Asn Val Gly 
    130                 135                 140                 


Ser Glu Arg His Ala Lys Leu Ile Thr Ser Leu Gln Asn Asp Ile Asn 
145                 150                 155                 160 


Thr Val Lys Glu Asn Ala Glu Lys Met Ser Glu His Tyr Lys Ile Thr 
                165                 170                 175     


Leu Glu Asp Thr Arg Lys Lys Ile Ile Lys Glu Thr Leu Leu Gln Leu 
            180                 185                 190         


Asp Gln Lys Lys Glu Trp Ala Thr Gln Asn Ala Val Lys Leu Ile Asp 
        195                 200                 205             


Lys Gly Ser Tyr Leu Glu Ile Trp Glu Asn Asp Trp Leu Lys Lys Glu 
    210                 215                 220                 


Val Ala Ile His Arg Lys Glu Val Glu Glu Leu Lys Asn Ala Ile His 
225                 230                 235                 240 


Glu Leu Glu Ala Glu Asn Leu Val Leu Ile Asp Gln Leu Ser Asn Cys 
                245                 250                 255     


Arg Leu Val Asp Leu Lys Ile Pro Arg Tyr Pro Val Leu His Ser Cys 
            260                 265                 270         


Pro Thr Ser Asn Pro Arg His Leu Leu Leu Leu Pro Leu Glu Ser Cys 
        275                 280                 285             


Leu Ile Ser Ala Arg Arg Cys Trp Arg Leu Tyr Leu Thr Gln Ala Ala 
    290                 295                 300                 


Gly Leu Glu Val Pro Pro Glu Glu Met Ser Leu Glu Leu Pro Glu Thr 
305                 310                 315                 320 


His Ile Glu Glu Lys Ser Glu Leu Gln Pro Thr Glu Val Glu Ser Arg 
                325                 330                 335     


Asp Leu Met Ser Ser Ser Asp Glu Ser Thr Ile Leu His Leu Ser His 
            340                 345                 350         


Glu Asn Ser Ile Glu Asp Leu Gln Tyr Val Lys Ile Asp Lys Glu Glu 
        355                 360                 365             


Asn Ser Gly Thr Glu Phe Gly Asp Thr Asp Met Lys Tyr Leu Leu Tyr 
    370                 375                 380                 


Glu Asp Glu Lys Asp Phe Lys Asp Tyr Val Asn Leu Gly Pro Leu Gly 
385                 390                 395                 400 


Val Lys Leu Met Ser Val Glu Ser Lys Lys Met Pro Ile His Phe Gln 
                405                 410                 415     


Glu Lys Glu Ile Pro Val Lys Leu Tyr Lys Asp Val Arg Ser Pro Glu 
            420                 425                 430         


Ser His Ile Thr Tyr Lys Met Met Lys Ser Phe Leu 
        435                 440                 


<210>  1295
<211>  3734
<212>  DNA
<213>  Homosapiens

<400>  1295
cctgttcctc ttaccctgcc cggctccagc tgaccaggga aggggtgggc tgaactgagg     60

cgggggcaag ggagtgcccg acatcttgtc cgactccgcg ggtgacacga gccggttctc    120

tctggactgg tggcagcgcg cggccccgaa ccgcgcccca ggccggcagg cggggaagga    180

gccggtgggg gtagggggtg cggtgggggg tggggaccct ccggctcttg ggggtcccag    240

tccccgccgg ctgctgagcg ggtggggtgg tggaggagct gcagagatgt ccggccagag    300

cctgacggac cgaatcactg ccgcccagca cagtgtcacc ggctctgccg tatccaagac    360

agtatgcaag gccacgaccc acgagatcat ggggcccaag aaaaagcacc tggactactt    420

aattcagtgc acaaatgaga tgaatgtgaa catcccacag ttggcagaca gtttatttga    480

aagaactact aatagtagtt gggtggtggt cttcaaatct ctcattacaa ctcatcattt    540

gatggtgtat ggaaatgagc gttttattca gtatttggct tcaagaaaca cgttgtttaa    600

cttaagcaat tttttggata aaagtggatt gcaaggatat gacatgtcta catttattag    660

gcggtatagt agatatttaa atgagaaagc agtttcatac agacaagttg catttgattt    720

cacaaaagtg aagagagggg ctgatggagt tatgagaaca atgaacacag aaaaactcct    780

aaaaactgta ccaattattc agaatcagat ggatgcactt cttgatttta atgttaatag    840

caatgaactt acaaatgggg taataaatgc tgccttcatg ctcctgttca aagatgccat    900

tagactgttt gcagcataca atgaaggaat tattaatttg ttggaaaaat attttgatat    960

gaaaaagaac caatgcaaag aaggtcttga catctataag aagttcctaa ctaggatgac   1020

aagaatctca gagttcctca aagttgcaga gcaagttgga attgacagag gtgatatacc   1080

agacctttca caggccccta gcagtcttct tgatgctttg gaacaacatt tagcttcctt   1140

ggaaggaaag aaaatcaaag attctacagc tgcaagcagg gcaactacac tttccaatgc   1200

agtgtcttcc ctggcaagca ctggtctatc tctgaccaaa gtggatgaaa gggaaaagca   1260

ggcagcatta gaggaagaac aggcacgttt gaaagcttta aaggaacagc gcctaaaaga   1320

acttgcaaag aaacctcata cctctttaac aactgcagcc tctcctgtat ccacctcagc   1380

aggagggata atgactgcac cagccattga catattttct acccctagtt cttctaacag   1440

cacatcaaag ctgcccaatg atctgcttga tttgcagcag ccaacttttc acccatctgt   1500

acatcctatg tcaactgctt ctcaggtagc aagtacatgg ggaggattca ctccttctcc   1560

agttgcacag ccacaccctt cagctggcct taatgttgac tttgaatctg tgtttggaaa   1620

taaatctaca aatgttattg tagattctgg gggctttgat gaactaggtg gacttctcaa   1680

accaacagtg gcctctcaga accagaacct tcctgttgcc aaactcccac ctagcaagtt   1740

agtatctgat gacttggatt catctttagc caaccttgtg ggcaatcttg gcatcggaaa   1800

tggaaccact aagaatgatg taaattggag tcaaccaggt gaaaagaagt taactggggg   1860

atctaactgg caaccaaagg ttgcaccaac aaccgcttgg aatgctgcaa caatgaatgg   1920

catgcatttt ccacaatacg caccccctgt aatggcctat cctgctacta caccaacagg   1980

catgatagga tatggaattc ctccacaaat gggaagtgtt cctgtaatga cgcaaccaac   2040

cttaatatac agccagcctg tcatgagacc tccaaacccc tttggccctg tatcaggagc   2100

acagatacag tttatgtaac ttgatggaag aaaatggaat tactccaaaa agacaagtgc   2160

tcaagcagca aaatccttac ttccagcaaa atccaaactg ctgtctctta aatctcttaa   2220

actctcttct tccattagaa tgctacaagt aactcagtga aggcccatga aggaaattgg   2280

gactagttta taggagaacg tatcaataca gtttataaag ccaagaattg ctatgattta   2340

agactaagat ctgtcttttt ggtgactaac ccttcaattc tttcaactcc tgttaatacc   2400

cataatcagt aacctatcaa gaaaagccct tatttggaaa gtgtgaaatt tgtatttgga   2460

aaagctgcct ggagagaaga actgtgtcct ttactgtatt tcaacaggac tcttttgggg   2520

gatcaaaatt aaaattccta attatgcatt atctttcttt tctccagtcc tcacaaatac   2580

agaaacaata actgaaatta acttttcttt ttttaaaaaa aattatattc agtttgcagt   2640

agacattcct taagtatttg tatttattta tgattatcaa ttttacataa cattaatatt   2700

gtatcagacc tccttatgaa aatgagtatg gatgtgcaca gtatgtttga tttttatcca   2760

caagaatgaa tctgattcag aatgcttttc tcagctgaca tacagagcac taaatatttt   2820

aaggcaagtc cataggtctg aatctcttaa gaattctcgg cctctgtggg atttagggaa   2880

gcattataaa tgcattaatc cttatagtca attctgtgcc taggattttg ccagggaaca   2940

gttcactgac taggaaaagc actacatttt aaattcagca ttagtgcatt gggaaggatc   3000

tttactgctt tgtgcttggc atgtcattat tttccatttg acattagggc ctttccaaaa   3060

tgaatgtgag gaattgcttt cacttcaaga ctttccttct tttcactaaa actctagaag   3120

gtgttacaag ggggagggaa ggggggcaaa gtccttgaac attttctttg gctcgtgcca   3180

tgttatgatc atataccttt taaataaggg gaaatagtat ctttaaagtt aatgtctagc   3240

caagagttta gtaaacgaag aattaaactg cactgttgat cggtgctttg tgtaaataca   3300

tctttaacat ttgggtggag aggggcctta agaaggacag ttcattgtag gaaagcaatt   3360

ctgtacatga gtttaagcat tcttgttgca ttgtctctgc agattctatt tttgtttaca   3420

atattaaaat gtatgttagc aaaatgggtg gattttcaaa taaaatgcag cttccacaaa   3480

agttttgtta tggtattctg gtctgagatg cattttcatt tttcctttct ctttttatta   3540

tcaatattgt catttttccc taataaaata tacccaggtg attatatttg ttgatctaat   3600

aacatggaag gtttgtttta tatgaatttt caaaaagatg tctctttaca ctttttgtta   3660

ccttgtagac tcttattgat aaatgcaact acttattaaa attgttcact ttttgtcttt   3720

tgaaaaaaaa aaaa                                                     3734


<210>  1296
<211>  610
<212>  PRT
<213>  Homosapiens

<400>  1296

Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser 
1               5                   10                  15      


Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His 
            20                  25                  30          


Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys 
        35                  40                  45              


Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe 
    50                  55                  60                  


Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile 
65                  70                  75                  80  


Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr 
                85                  90                  95      


Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys 
            100                 105                 110         


Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser 
        115                 120                 125             


Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp 
    130                 135                 140                 


Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn 
145                 150                 155                 160 


Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp 
                165                 170                 175     


Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val 
            180                 185                 190         


Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe 
        195                 200                 205             


Ala Ala Tyr Asn Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp 
    210                 215                 220                 


Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe 
225                 230                 235                 240 


Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln 
                245                 250                 255     


Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser 
            260                 265                 270         


Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys 
        275                 280                 285             


Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn 
    290                 295                 300                 


Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp 
305                 310                 315                 320 


Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys 
                325                 330                 335     


Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr 
            340                 345                 350         


Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile 
        355                 360                 365             


Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn 
    370                 375                 380                 


Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr 
385                 390                 395                 400 


Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser 
                405                 410                 415     


Thr Trp Gly Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His Pro Ser 
            420                 425                 430         


Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys Ser Thr 
        435                 440                 445             


Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly Leu Leu 
    450                 455                 460                 


Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala Lys Leu 
465                 470                 475                 480 


Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu Ala Asn 
                485                 490                 495     


Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn Asp Val 
            500                 505                 510         


Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser Asn Trp 
        515                 520                 525             


Gln Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr Met Asn 
    530                 535                 540                 


Gly Met His Phe Pro Gln Tyr Ala Pro Pro Val Met Ala Tyr Pro Ala 
545                 550                 555                 560 


Thr Thr Pro Thr Gly Met Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly 
                565                 570                 575     


Ser Val Pro Val Met Thr Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val 
            580                 585                 590         


Met Arg Pro Pro Asn Pro Phe Gly Pro Val Ser Gly Ala Gln Ile Gln 
        595                 600                 605             


Phe Met 
    610 


<210>  1297
<211>  3860
<212>  DNA
<213>  Homosapiens

<400>  1297
cctgttcctc ttaccctgcc cggctccagc tgaccaggga aggggtgggc tgaactgagg     60

cgggggcaag ggagtgcccg acatcttgtc cgactccgcg ggtgacacga gccggttctc    120

tctggactgg tggcagcgcg cggccccgaa ccgcgcccca ggccggcagg cggggaagga    180

gccggtgggg gtagggggtg cggtgggggg tggggaccct ccggctcttg ggggtcccag    240

tccccgccgg ctgctgagcg ggtggggtgg tggaggagct gcagagatgt ccggccagag    300

cctgacggac cgaatcactg ccgcccagca cagtgtcacc ggctctgccg tatccaagac    360

agtatgcaag gccacgaccc acgagatcat ggggcccaag aaaaagcacc tggactactt    420

aattcagtgc acaaatgaga tgaatgtgaa catcccacag ttggcagaca gtttatttga    480

aagaactact aatagtagtt gggtggtggt cttcaaatct ctcattacaa ctcatcattt    540

gatggtgtat ggaaatgagc gttttattca gtatttggct tcaagaaaca cgttgtttaa    600

cttaagcaat tttttggata aaagtggatt gcaaggatat gacatgtcta catttattag    660

gcggtatagt agatatttaa atgagaaagc agtttcatac agacaagttg catttgattt    720

cacaaaagtg aagagagggg ctgatggagt tatgagaaca atgaacacag aaaaactcct    780

aaaaactgta ccaattattc agaatcagat ggatgcactt cttgatttta atgttaatag    840

caatgaactt acaaatgggg taataaatgc tgccttcatg ctcctgttca aagatgccat    900

tagactgttt gcagcataca atgaaggaat tattaatttg ttggaaaaat attttgatat    960

gaaaaagaac caatgcaaag aaggtcttga catctataag aagttcctaa ctaggatgac   1020

aagaatctca gagttcctca aagttgcaga gcaagttgga attgacagag gtgatatacc   1080

agacctttca caggccccta gcagtcttct tgatgctttg gaacaacatt tagcttcctt   1140

ggaaggaaag aaaatcaaag attctacagc tgcaagcagg gcaactacac tttccaatgc   1200

agtgtcttcc ctggcaagca ctggtctatc tctgaccaaa gtggatgaaa gggaaaagca   1260

ggcagcatta gaggaagaac aggcacgttt gaaagcttta aaggaacagc gcctaaaaga   1320

acttgcaaag aaacctcata cctctttaac aactgcagcc tctcctgtat ccacctcagc   1380

aggagggata atgactgcac cagccattga catattttct acccctagtt cttctaacag   1440

cacatcaaag ctgcccaatg atctgcttga tttgcagcag ccaacttttc acccatctgt   1500

acatcctatg tcaactgctt ctcaggtagc aagtacatgg ggagatcctt tctctgctac   1560

tgtagatgct gttgatgatg ccattccaag cttaaatcct ttcctcacaa aaagtagtgg   1620

tgatgttcac ctttccattt cttcagatgt atctactttt actactagga cacctactca   1680

tgaaatgttt gttggattca ctccttctcc agttgcacag ccacaccctt cagctggcct   1740

taatgttgac tttgaatctg tgtttggaaa taaatctaca aatgttattg tagattctgg   1800

gggctttgat gaactaggtg gacttctcaa accaacagtg gcctctcaga accagaacct   1860

tcctgttgcc aaactcccac ctagcaagtt agtatctgat gacttggatt catctttagc   1920

caaccttgtg ggcaatcttg gcatcggaaa tggaaccact aagaatgatg taaattggag   1980

tcaaccaggt gaaaagaagt taactggggg atctaactgg caaccaaagg ttgcaccaac   2040

aaccgcttgg aatgctgcaa caatggcacc ccctgtaatg gcctatcctg ctactacacc   2100

aacaggcatg ataggatatg gaattcctcc acaaatggga agtgttcctg taatgacgca   2160

accaacctta atatacagcc agcctgtcat gagacctcca aacccctttg gccctgtatc   2220

aggagcacag atacagttta tgtaacttga tggaagaaaa tggaattact ccaaaaagac   2280

aagtgctcaa gcagcaaaat ccttacttcc agcaaaatcc aaactgctgt ctcttaaatc   2340

tcttaaactc tcttcttcca ttagaatgct acaagtaact cagtgaaggc ccatgaagga   2400

aattgggact agtttatagg agaacgtatc aatacagttt ataaagccaa gaattgctat   2460

gatttaagac taagatctgt ctttttggtg actaaccctt caattctttc aactcctgtt   2520

aatacccata atcagtaacc tatcaagaaa agcccttatt tggaaagtgt gaaatttgta   2580

tttggaaaag ctgcctggag agaagaactg tgtcctttac tgtatttcaa caggactctt   2640

ttgggggatc aaaattaaaa ttcctaatta tgcattatct ttcttttctc cagtcctcac   2700

aaatacagaa acaataactg aaattaactt ttcttttttt aaaaaaaatt atattcagtt   2760

tgcagtagac attccttaag tatttgtatt tatttatgat tatcaatttt acataacatt   2820

aatattgtat cagacctcct tatgaaaatg agtatggatg tgcacagtat gtttgatttt   2880

tatccacaag aatgaatctg attcagaatg cttttctcag ctgacataca gagcactaaa   2940

tattttaagg caagtccata ggtctgaatc tcttaagaat tctcggcctc tgtgggattt   3000

agggaagcat tataaatgca ttaatcctta tagtcaattc tgtgcctagg attttgccag   3060

ggaacagttc actgactagg aaaagcacta cattttaaat tcagcattag tgcattggga   3120

aggatcttta ctgctttgtg cttggcatgt cattattttc catttgacat tagggccttt   3180

ccaaaatgaa tgtgaggaat tgctttcact tcaagacttt ccttcttttc actaaaactc   3240

tagaaggtgt tacaaggggg agggaagggg ggcaaagtcc ttgaacattt tctttggctc   3300

gtgccatgtt atgatcatat accttttaaa taaggggaaa tagtatcttt aaagttaatg   3360

tctagccaag agtttagtaa acgaagaatt aaactgcact gttgatcggt gctttgtgta   3420

aatacatctt taacatttgg gtggagaggg gccttaagaa ggacagttca ttgtaggaaa   3480

gcaattctgt acatgagttt aagcattctt gttgcattgt ctctgcagat tctatttttg   3540

tttacaatat taaaatgtat gttagcaaaa tgggtggatt ttcaaataaa atgcagcttc   3600

cacaaaagtt ttgttatggt attctggtct gagatgcatt ttcatttttc ctttctcttt   3660

ttattatcaa tattgtcatt tttccctaat aaaatatacc caggtgatta tatttgttga   3720

tctaataaca tggaaggttt gttttatatg aattttcaaa aagatgtctc tttacacttt   3780

ttgttacctt gtagactctt attgataaat gcaactactt attaaaattg ttcacttttt   3840

gtcttttgaa aaaaaaaaaa                                               3860


<210>  1298
<211>  652
<212>  PRT
<213>  Homosapiens

<400>  1298

Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser 
1               5                   10                  15      


Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His 
            20                  25                  30          


Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys 
        35                  40                  45              


Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe 
    50                  55                  60                  


Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile 
65                  70                  75                  80  


Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr 
                85                  90                  95      


Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys 
            100                 105                 110         


Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser 
        115                 120                 125             


Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp 
    130                 135                 140                 


Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn 
145                 150                 155                 160 


Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp 
                165                 170                 175     


Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val 
            180                 185                 190         


Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe 
        195                 200                 205             


Ala Ala Tyr Asn Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp 
    210                 215                 220                 


Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe 
225                 230                 235                 240 


Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln 
                245                 250                 255     


Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser 
            260                 265                 270         


Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys 
        275                 280                 285             


Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn 
    290                 295                 300                 


Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp 
305                 310                 315                 320 


Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys 
                325                 330                 335     


Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr 
            340                 345                 350         


Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile 
        355                 360                 365             


Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn 
    370                 375                 380                 


Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr 
385                 390                 395                 400 


Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser 
                405                 410                 415     


Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala 
            420                 425                 430         


Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His 
        435                 440                 445             


Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr 
    450                 455                 460                 


His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His 
465                 470                 475                 480 


Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys 
                485                 490                 495     


Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly 
            500                 505                 510         


Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala 
        515                 520                 525             


Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu 
    530                 535                 540                 


Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn 
545                 550                 555                 560 


Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser 
                565                 570                 575     


Asn Trp Gln Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr 
            580                 585                 590         


Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met 
        595                 600                 605             


Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr 
    610                 615                 620                 


Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro 
625                 630                 635                 640 


Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met 
                645                 650         


<210>  1299
<211>  5587
<212>  DNA
<213>  Homosapiens

<400>  1299
ggccttcgtc cctactgcct gggcgcgggg cgggaggcgg tgaccagcag caggaggaga     60

aagaacatgg cgggcgcatc agagctcggg accggcccag gagcagcggg tggagatgga    120

gatgattcgc tatacccgat cgcggtttta atcgacgagc tccgcaatga agacgtgcag    180

ctccgactca acagtattaa gaagttatca acaattgccc tagcacttgg agtagaaagg    240

acccgaagtg aattgttgcc atttcttaca gatacaattt atgatgaaga tgaggtacta    300

ttagctcttg ctgagcagct gggaaatttc actggcctag tgggaggtcc tgactttgcc    360

cactgtctgc tgcctccttt ggaaaatctg gcaactgtgg aagagactgt tgttcgtgac    420

aaggctgtgg agtccctgag acagatctcc caggagcata ctcctgttgc tctggaagct    480

tattttgtac ctctggtgaa acgcttagca agtggggatt ggttcacctc tcgcacatct    540

gcatgtggtt tgttcagcgt ttgctatccc agggcatcaa atgctgttaa agcagaaatc    600

agacagcaat tccgttcctt gtgctcagat gacacaccaa tggtacgacg tgctgctgct    660

tccaaattgg gtgaatttgc aaaagttttg gaattagaca gtgtgaaaag tgaaattgtt    720

ccactgttca ctagtctagc ttcagatgaa caggattcag tgcgcctcct tgctgtggaa    780

gcttgtgtca gtattgccca gttattgtct caggatgacc ttgagacttt ggtgatgcct    840

acacttcgac aagcagcaga agataaatct tggcgcgttc gctatatggt ggctgacaga    900

ttttcagagc tccagaaagc catgggtcct aaaatcaccc taaatgacct catccccgcc    960

tttcagaacc tacttaaaga ctgtgaagct gaagtccggg cagctgctgc ccacaaagta   1020

aaagaacttg gtgagaactt gcccattgaa gatagagaga ccataattat gaatcaaatt   1080

ctgccttata taaaggaatt agtatccgat accaatcaac atgtcaaatc ggctctagct   1140

tctgtaatta tgggattgtc tactattttg ggcaaagaaa ataccattga acatcttcta   1200

cctcttttct tagctcagtt aaaggatgag tgtcctgacg ttcgtttgaa tatcatctcc   1260

aatttggatt gtgtaaatga agtgattgga atccgtcagc tctctcagtc tctccttcct   1320

gccatagtgg agctggcaga agatgccaaa tggagggtcc gcctggccat cattgagtat   1380

atgccgctgc tggcaggcca gctgggtgtg gaattctttg atgaaaagct gaattcttta   1440

tgtatggctt ggctcgtgga ccatgtatac gccatccgag aagctgccac caacaacctc   1500

atgaaactag ttcagaagtt tggtacagag tgggcccaaa atactattgt tcccaaagtg   1560

ttagtaatgg caaatgatcc taattacttg catagaatga ccactttatt ctgcattaat   1620

gcactgtctg aggcctgtgg tcaggaaata actactaagc aaatgctgcc catcgtatta   1680

aaaatggcag gagaccaagt agcaaatgtt cgcttcaatg tggccaaatc tctacaaaag   1740

attggaccaa ttctagatac caatgcttta cagggagaag tgaagccagt actacagaag   1800

ttaggtcaag atgaagacat ggatgtcaaa tactttgcac aggaagctat aagtgttctt   1860

gcattggcat aatgaggagc aggagggaaa aggcctttac tagattcttg tcacaaattt   1920

ctagtcaatg tgttcttaac tgggtggaga aagaatggaa aaccttcaag atctcatcca   1980

agcaaatggc aacaacttag aagaaatcat ttagtgactt aattctttct aaagatgaaa   2040

tgggattgtt ttttactcgt cttccttgtt aaatcattat ttaagccgtt cttattgacc   2100

aattcctgac acttgattgt ctcctaatgc tttatccatc accacctggg ctcctgcatc   2160

ctcactgtgg aatcaggcac cagccacata atgttccaga caaagcctgg aagggtgtgg   2220

acccagacgt ggagtggagt gattctcttg acgtttacat atatctctgt gtctctccat   2280

cattccaaag ctaaatgtac atgtttagaa taacttattt tataaactct tcgggagaca   2340

tgttgagatt tgaccgtaat gaaagccaca ttttcctgaa ttatgatggt ctgcattagt   2400

ctcatgtgaa aggggaatgt ggaagctcag ggttaatgta gtggttgttt tggtttttat   2460

ttgctcaatt ttgtctgtac tcatgtcatt cagaaacctg aagtgtggct gcatcttgct   2520

gctaatgtgt gatgttgacg cctaactgaa tttgaacagc tcaccactgt gcctacattt   2580

aaaaatactt ctctctcttt tctaaaaagc tttaactgta gtgcctccta ataagcagta   2640

tgtttgtttc attgtgagat tgcagttctg tatttcgaat gagtctaaga accacaggga   2700

taatactgtg cagatttcct gttctttacc tggctctgct tccagcagta ttgacaccta   2760

gtccttgctg cattgtacag tagcttttca aactgcagtt ttattgctaa gtttttagta   2820

tgggtgatac tggagtctta tcatttgaag tgtttgcttt tctactttta cagtaaaacc   2880

tcattaattc tgaaatttaa gataatgagt taagctgaag agtttactga agcaaattaa   2940

tagtgaggaa gcctatttga actacttaaa cagtattaaa gcccttttta aaaagcacct   3000

atttgggatc atttgaggtc aagaattcga gatcagcctg accaacatgg tgaaacccca   3060

tctctactaa aaatacaaaa aagttagctg ggcgtggtgg cacacacctg tagtcccagc   3120

tactcaggag gctgaggcag gagaattgct tgaacctggg aggtagaggt tgcactgagc   3180

cgagatcgcg ccactgcact ctagcctggg ccatagagcg agagtccatc tcaaaaaaaa   3240

acaactattt ttcacataat caaactcacc ttgtctcatg acttttggtt aagggggttt   3300

tcccatagtt tatttttctc tcagtgcatc ttgctatgag gtttgcttgt tacccttttg   3360

gtttttgaat tgttgatttt gttcacaacc tcttttaaat ctaacaagtc ctgttctgtt   3420

tagtgaaggc ccaaagactc ctctaagact ttgtatattt gttacataaa accaagtttt   3480

actaaatact ttaaaatttg tcctacattc gaaaaataga aattgtaaat cagaggttat   3540

ctgtctgcat tttaaactgc caaattacct tatagtaagt ttctatttta tgactttggg   3600

ccaagaatta agtattttcc taagcacaaa tctttttcta tattctcatt ttaatatctt   3660

atgctattat tctgtaaaca ttttaatttt agtttcatga gtctttattt tttgttacct   3720

gcaagttatg ttcttcttca ttgaatttca tatttgagag acatttgtct tcatgaagca   3780

gatttgcact ggaaccattg ctttactctg gttggaaatg ccattgtttt ggggacagac   3840

ttttaaaatg cccttgtgtc tcccagtgag gagccctaag cattgacttc tctaccctaa   3900

aactgtttga gagagggaga gtgggccctg gctttctcaa gcatgggtcg ggggttcagc   3960

ggggcctctg tcttttgtgg tgacccctca ggggtttcat tgtttccttc tgacttaagc   4020

aatagagaga gaatttgttt tggtactctt cagaggaatt gtgctttggc tcataacttg   4080

gccatgttct ccatgaatta gttctcctat tttttttttt aactacctta aacttaaggg   4140

aaaagttctc ctatcttgat ttcactggaa tataggcttt aggagctctg taaggctggt   4200

atttttgtct gttttatctt ctactgtatc gccagtgcct ggaacagtgt ctggtgcaca   4260

taataggtgc tcaataaaaa tgtgttcaat ggatgaattt ctaaaatatc ctccaatgtg   4320

tgcatggaac aaataatcaa aagaaccaga ctgtgtctta ttctcccact gacagaaaga   4380

ttttcctgct ttcaggaaac aagctttatg tggccctttt ctggtcccct ggcttagact   4440

acagttctgt gtggatttgt ctgattgctt cagacatgta atgttgtttt tcatccttgg   4500

cagcttacat cagttgtttg tttgattaga aaaatgaagc agacacacac acacacacac   4560

acacacacac acacacacac acacaaacat ataacctatg ccaataaaaa tgtctcagca   4620

acagtggaat tcaccttggt gtttctctct gtaatttgtg tggggtttac ccctcacagg   4680

tttaagagac caggtcttgt ttctctctct gtgctaccaa gaagatgtga acctgaggat   4740

gcatcttgtt tcataagaag gaaggcaggt gaatatgtgg tttctaacga ggtcttgttg   4800

aaataacggg ctgccctcag ctcacagaaa taccacagct cagccactgt gatgcagagc   4860

cccaggggtc tttgccagac aacttgtcct gactcaacag agacggcagc ctgacctttg   4920

agctggcttg tccaggcatt caggttgctt gcgtagactt ccagggaagc aagcctgtcc   4980

ttcctgaccc ggcggttaac ctggtgcact tttgttcctt tgttaactgt tgtgttgtca   5040

ctaaactgaa aggctggggc ttgcccttag acgtcacatt ggctctgtcc ctgtggcgat   5100

ggcagggcag ggtggccaaa caggtcaggt gcttgttctg tcctcttgcc ttttacttaa   5160

attcctctga cttttaaaaa tggtgacact cttatcgtaa agcttcttat ttttctccac   5220

tgcttggata tgaaactgta gagggagagg ccctgttgcc cagtgttctc ctggtttagc   5280

agctgaggtg actgcagtct gatgtgatgt aactgtttcc ctttgattct ccagtattcc   5340

tgtttccatc cagttcctta ctctcctctt tcctcttccc tcgcatgtct ccctccagtc   5400

ctctgtacct agaatagtct cactgtcccc cgtttgcctc cacgagcctg ctgtttccag   5460

gaaattacat aacgttcagt tgggatggaa atcttccgga ggacgaatag agtttaatta   5520

ctcattgcgt cggaaagcca agccatttct gtctccagag ttgttctctt aaactgatat   5580

gagttct                                                             5587


<210>  1300
<211>  601
<212>  PRT
<213>  Homosapiens

<400>  1300

Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu 
            20                  25                  30          


Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser 
        35                  40                  45              


Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu 
    50                  55                  60                  


Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala 
65                  70                  75                  80  


Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp 
                85                  90                  95      


Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu 
            100                 105                 110         


Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser 
        115                 120                 125             


Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val 
    130                 135                 140                 


Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys 
145                 150                 155                 160 


Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala 
                165                 170                 175     


Glu Ile Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met 
            180                 185                 190         


Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu 
        195                 200                 205             


Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu 
    210                 215                 220                 


Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys 
225                 230                 235                 240 


Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val 
                245                 250                 255     


Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg 
            260                 265                 270         


Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro 
        275                 280                 285             


Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys 
    290                 295                 300                 


Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu 
305                 310                 315                 320 


Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn 
                325                 330                 335     


Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His 
            340                 345                 350         


Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu 
        355                 360                 365             


Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln 
    370                 375                 380                 


Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu 
385                 390                 395                 400 


Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu 
                405                 410                 415     


Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg 
            420                 425                 430         


Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val 
        435                 440                 445             


Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val 
    450                 455                 460                 


Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys 
465                 470                 475                 480 


Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro 
                485                 490                 495     


Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr 
            500                 505                 510         


Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile 
        515                 520                 525             


Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln 
    530                 535                 540                 


Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly 
545                 550                 555                 560 


Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu 
                565                 570                 575     


Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln 
            580                 585                 590         


Glu Ala Ile Ser Val Leu Ala Leu Ala 
        595                 600     


<210>  1301
<211>  2139
<212>  DNA
<213>  Homosapiens

<400>  1301
ggccttcgtc cctactgcct gggcgcgggg cgggaggcgg tgaccagcag caggaggaga     60

aagaacatgg cgggcgcatc agagctcggg accggcccag gagcagcggg tggagatgga    120

gatgattcgc tatacccgat cgcggtttta atcgacgagc tccgcaatga agacgtgcag    180

ctccgactca acagtattaa gaagttatca acaattgccc tagcacttgg agtagaaagg    240

acccgaagtg aattgttgcc atttcttaca gatacaattt atgatgaaga tgaggtacta    300

ttagctcttg ctgagcagct gggaaatttc actggcctag tgggaggtcc tgactttgcc    360

cactgtctgc tgcctccttt ggaaaatctg gcaactgtgg aagagactgt tgttcgtgac    420

aaggctgtgg agtccctgag acagatctcc caggagcata ctcctgttgc tctggaagct    480

tattttgtac ctctggtgaa acgcttagca agtggggatt ggttcacctc tcgcacatct    540

gcatgtggtt tgttcagcgt ttgctatccc agggcatcaa atgctgttaa agcagaaatc    600

agacagcaat tccgttcctt gtgctcagat gacacaccaa tggtacgacg tgctgctgct    660

tccaaattgg gtgaatttgc aaaagttttg gaattagaca gtgtgaaaag tgaaattgtt    720

ccactgttca ctagtctagc ttcagatgaa caggattcag tgcgcctcct tgctgtggaa    780

gcttgtgtca gtattgccca gttattgtct caggatgacc ttgagacttt ggtgatgcct    840

acacttcgac aagcagcaga agataaatct tggcgcgttc gctatatggt ggctgacaga    900

ttttcagagc tccagaaagc catgggtcct aaaatcaccc taaatgacct catccccgcc    960

tttcagaacc tacttaaaga ctgtgaagct gaagtccggg cagctgctgc ccacaaagta   1020

aaagaacttg gtgagaactt gcccattgaa gatagagaga ccataattat gaatcaaatt   1080

ctgccttata taaaggaatt agtatccgat accaatcaac atgtcaaatc ggctctagct   1140

tctgtaatta tgggattgtc tactattttg ggcaaagaaa ataccattga acatcttcta   1200

cctcttttct tagctcagtt aaaggatgag tgtcctgacg ttcgtttgaa tatcatctcc   1260

aatttggatt gtgtaaatga agtgattgga atccgtcagc tctctcagtc tctccttcct   1320

gccatagtgg agctggcaga agatgccaaa tggagggtcc gcctggccat cattgagtat   1380

atgccgctgc tggcaggcca gctgggtgtg gaattctttg atgaaaagct gaattcttta   1440

tgtatggctt ggctcgtgga ccatgtatac gccatccgag aagctgccac caacaacctc   1500

atgaaactag ttcagaagtt tggtacagag tgggcccaaa atactattgt tcccaaagtg   1560

ttagtaatgg caaatgatcc taattacttg catagaatga ccactttatt ctgcattaat   1620

gcactgtctg aggcctgtgg tcaggaaata actactaagc aaatgctgcc catcgtatta   1680

aaaatggcag gagaccaagt agcaaatgtt cgcttcaatg tggccaaatc tctacaaaag   1740

attggaccaa ttctagatac caatgcttta cagggagaag tgaagccagt actacagaag   1800

ttaggtcaag atgaagacat ggatgtcaaa tactttgcac aggaagctat aagtgtggtg   1860

gcacaaaggc tgaggaagct agaatttcct gtgaaggaca gtggagaacc cagtgtccct   1920

cgggctgaca agaaccactt cccaagaccc acagtgcctg gagaggacat ggggaaggga   1980

ccagtgtatc agttgcgtgg agatactaga gacacacttg cccagctggg aattgcagag   2040

ctagtgcatt tctcccaaag cacagactaa taccccagat ttaaaaaaag aacataaaaa   2100

ataaagtacc acacatattg cacaaaaaaa aaaaaaaaa                          2139


<210>  1302
<211>  667
<212>  PRT
<213>  Homosapiens

<400>  1302

Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu 
            20                  25                  30          


Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser 
        35                  40                  45              


Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu 
    50                  55                  60                  


Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala 
65                  70                  75                  80  


Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp 
                85                  90                  95      


Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu 
            100                 105                 110         


Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser 
        115                 120                 125             


Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val 
    130                 135                 140                 


Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys 
145                 150                 155                 160 


Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala 
                165                 170                 175     


Glu Ile Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met 
            180                 185                 190         


Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu 
        195                 200                 205             


Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu 
    210                 215                 220                 


Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys 
225                 230                 235                 240 


Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val 
                245                 250                 255     


Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg 
            260                 265                 270         


Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro 
        275                 280                 285             


Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys 
    290                 295                 300                 


Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu 
305                 310                 315                 320 


Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn 
                325                 330                 335     


Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His 
            340                 345                 350         


Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu 
        355                 360                 365             


Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln 
    370                 375                 380                 


Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu 
385                 390                 395                 400 


Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu 
                405                 410                 415     


Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg 
            420                 425                 430         


Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val 
        435                 440                 445             


Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val 
    450                 455                 460                 


Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys 
465                 470                 475                 480 


Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro 
                485                 490                 495     


Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr 
            500                 505                 510         


Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile 
        515                 520                 525             


Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln 
    530                 535                 540                 


Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly 
545                 550                 555                 560 


Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu 
                565                 570                 575     


Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln 
            580                 585                 590         


Glu Ala Ile Ser Val Val Ala Gln Arg Leu Arg Lys Leu Glu Phe Pro 
        595                 600                 605             


Val Lys Asp Ser Gly Glu Pro Ser Val Pro Arg Ala Asp Lys Asn His 
    610                 615                 620                 


Phe Pro Arg Pro Thr Val Pro Gly Glu Asp Met Gly Lys Gly Pro Val 
625                 630                 635                 640 


Tyr Gln Leu Arg Gly Asp Thr Arg Asp Thr Leu Ala Gln Leu Gly Ile 
                645                 650                 655     


Ala Glu Leu Val His Phe Ser Gln Ser Thr Asp 
            660                 665         


<210>  1303
<211>  2094
<212>  DNA
<213>  Homosapiens

<400>  1303
gtcttttgtc cctcggcgga caccgtttgc cagccaaagc tatgtctgcg cgctcaccga     60

cttcataggg tgccgaattc ttttttcccc aggcttgcca tggctagtcg aggggctcgg    120

cagcgcctga agggcagcgg ggccagcagt ggggatacgg ccccggctgc ggacaagctg    180

cgggagctgc tgggcagccg agaggcgggc ggcgcggagc accggaccga gttatctggg    240

aacaaagcag gacaagtctg ggcacctgaa ggatctactg ctttcaagtg tctgctttca    300

gcaaggttat gtgctgctct cctgagcaac atctctgact gtgatgaaac attcaactac    360

tgggagccaa cacactacct catctatggg gaagggtttc agacttggga atattcccca    420

gcatatgcca ttcgctccta tgcttacctg ttgcttcatg cctggccagc tgcatttcat    480

gcaagaattc tacaaactaa taagattctt gtgttttact ttttgcgatg tcttctggct    540

tttgtgagct gtatttgtga actttacttt tacaaggctg tgtgcaagaa gtttgggttg    600

cacgtgagtc gaatgatgct agccttcttg gttctcagca ctggcatgtt ttgctcatca    660

tcagcattcc ttcctagtag cttctgtatg tacactacgt tgatagccat gactggatgg    720

tatatggaca agacttccat tgctgtgctg ggagtagcag ctggggctat cttaggctgg    780

ccattcagtg cagctcttgg tttacccatt gcctttgatt tgctggtcat gaaacacagg    840

tggaagagtt tctttcattg gtcgctgatg gccctcatac tatttctggt gcctgtggtg    900

gtcattgaca gctactatta tgggaagttg gtgattgcac cactcaacat tgttttgtat    960

aatatcttta ctcctcatgg acctgatctt tatggtacag aaccctggta tttctattta   1020

attaatggat ttctgaattt caatgtagcc tttgctttgg ctctcctagt cctaccactg   1080

acttctctta tggaatacct gctgcagaga tttcatgttc agaatttagg ccacccgtat   1140

tggcttacct tggctccaat gtatatttgg tttataattt tcttcatcca gcctcacaaa   1200

gaggagagat ttcttttccc tgtgtatcca cttatatgtc tctgtggcgc tgtggctctc   1260

tctgcacttc agcacagttt tctgtacttc cagaaatgtt accactttgt gtttcaacga   1320

tatcgcctgg agcactatac tgtgacatcg aattggctgg cattaggaac tgtcttcctg   1380

tttgggctct tgtcattttc tcgctctgtg gcactgttca gaggatatca cgggcccctt   1440

gatttgtatc cagaatttta ccgaattgct acagacccaa ccatccacac tgtcccagaa   1500

ggcagacctg tgaatgtctg tgtgggaaaa gagtggtatc gatttcccag cagcttcctt   1560

cttcctgaca attggcagct tcagttcatt ccatcagagt tcagaggtca gttaccaaaa   1620

ccttttgcag aaggacctct ggccacccgg attgttccta ctgacatgaa tgaccagaat   1680

ctagaagagc catccagata tattgatatc agtaaatgcc attatttagt ggatttggac   1740

accatgagag aaacaccccg ggagccaaaa tattcatcca ataaagaaga atggatcagc   1800

ttggcctata gaccattcct tgatgcttct agatcttcaa agctgctgcg ggcattctat   1860

gtccccttcc tgtcagatca gtatacagtg tacgtaaact acaccatcct caaaccccgg   1920

aaagcaaagc aaatcaggaa gaaaagtgga ggttagcaac acacctgtgg ccccaaagga   1980

caaccatctt gttaactatt gattccagtg acctgactcc ctgcaagtca tcgcctgtaa   2040

catttgtaat aaaggtcttc tgacatgaaa aaaaaaaaaa aaaaaaaaaa aaaa         2094


<210>  1304
<211>  618
<212>  PRT
<213>  Homosapiens

<400>  1304

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Ala Phe Leu Pro 
            180                 185                 190         


Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala Met Thr Gly Trp Tyr 
        195                 200                 205             


Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val Ala Ala Gly Ala Ile 
    210                 215                 220                 


Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu Pro Ile Ala Phe Asp 
225                 230                 235                 240 


Leu Leu Val Met Lys His Arg Trp Lys Ser Phe Phe His Trp Ser Leu 
                245                 250                 255     


Met Ala Leu Ile Leu Phe Leu Val Pro Val Val Val Ile Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn Ile Val Leu Tyr Asn 
        275                 280                 285             


Ile Phe Thr Pro His Gly Pro Asp Leu Tyr Gly Thr Glu Pro Trp Tyr 
    290                 295                 300                 


Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn Val Ala Phe Ala Leu 
305                 310                 315                 320 


Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met Glu Tyr Leu Leu Gln 
                325                 330                 335     


Arg Phe His Val Gln Asn Leu Gly His Pro Tyr Trp Leu Thr Leu Ala 
            340                 345                 350         


Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile Gln Pro His Lys Glu 
        355                 360                 365             


Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile Cys Leu Cys Gly Ala 
    370                 375                 380                 


Val Ala Leu Ser Ala Leu Gln His Ser Phe Leu Tyr Phe Gln Lys Cys 
385                 390                 395                 400 


Tyr His Phe Val Phe Gln Arg Tyr Arg Leu Glu His Tyr Thr Val Thr 
                405                 410                 415     


Ser Asn Trp Leu Ala Leu Gly Thr Val Phe Leu Phe Gly Leu Leu Ser 
            420                 425                 430         


Phe Ser Arg Ser Val Ala Leu Phe Arg Gly Tyr His Gly Pro Leu Asp 
        435                 440                 445             


Leu Tyr Pro Glu Phe Tyr Arg Ile Ala Thr Asp Pro Thr Ile His Thr 
    450                 455                 460                 


Val Pro Glu Gly Arg Pro Val Asn Val Cys Val Gly Lys Glu Trp Tyr 
465                 470                 475                 480 


Arg Phe Pro Ser Ser Phe Leu Leu Pro Asp Asn Trp Gln Leu Gln Phe 
                485                 490                 495     


Ile Pro Ser Glu Phe Arg Gly Gln Leu Pro Lys Pro Phe Ala Glu Gly 
            500                 505                 510         


Pro Leu Ala Thr Arg Ile Val Pro Thr Asp Met Asn Asp Gln Asn Leu 
        515                 520                 525             


Glu Glu Pro Ser Arg Tyr Ile Asp Ile Ser Lys Cys His Tyr Leu Val 
    530                 535                 540                 


Asp Leu Asp Thr Met Arg Glu Thr Pro Arg Glu Pro Lys Tyr Ser Ser 
545                 550                 555                 560 


Asn Lys Glu Glu Trp Ile Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala 
                565                 570                 575     


Ser Arg Ser Ser Lys Leu Leu Arg Ala Phe Tyr Val Pro Phe Leu Ser 
            580                 585                 590         


Asp Gln Tyr Thr Val Tyr Val Asn Tyr Thr Ile Leu Lys Pro Arg Lys 
        595                 600                 605             


Ala Lys Gln Ile Arg Lys Lys Ser Gly Gly 
    610                 615             


<210>  1305
<211>  2611
<212>  DNA
<213>  Homosapiens

<400>  1305
cttttttcac ctcgtctgaa atggctgcct cccagtgtct ctgctgctca aaatttctct     60

tccagagaca gaacctcgcc tgtttcctca caaacccaca ctgtggcagc cttgttaatg    120

cagatggcca tggtgaagtg tggacagact ggaataatat gtccaagttt ttccagtatg    180

gatggcgatg caccactaat gagaatacct attcaaaccg taccctgatg ggcaactgga    240

accaggaaag atatgacctg aggaatatcg tgcagcccaa acccttgcct tcccagtttg    300

gacactactt tgaaacaaca tatgatacaa gctacaacaa caaaatgcca ctttcaacac    360

atagatttaa gcgagagcct cactggttcc caggacatca acctgaactg gatcctcccc    420

gatacaaatg cacagaaaag tcaacttaca tgaatagcta ttcaaagcct taaattgggc    480

atcactcagg atgtgtataa gatcttaata ttgatagttt cacatccagg tttctaagaa    540

atgataagat acttcacttt tccagagtga aatgtaggag ggagcacatt ctaagtacag    600

ctaaaaattt agctcactgt aacacagttt cactctctga ataaataaag caaaaaacac    660

agtaaatatt ctttatccct ttttttgttg ttgttttaac caagatttaa atgtcaaatt    720

taatacagca actcagttct acatttgggg tgttgtagaa gggccttaaa aagaattatt    780

ttaggccagg cacggtggct catgcctgta atcccagcac tttgggaggc cgaggcaggt    840

ggatcacgtg aggtcaggag ttcgagacca gcctgaccaa catggtgaaa cactgtctct    900

actaaaaaca caaaaattag ctgagcatgg tggctcacgc ctgtaatccc agctactcag    960

gaggctgagg caggggaatc gcttgaacct gagaagtgga ggttgtggtg agctgagatc   1020

atgccactgc actttagcct gggtgacaga gcgagactct gtctcaaaaa aaaaaaaaaa   1080

aaaagaatta tttctctgaa gtctacaacc actgtggtct tcccttcctt ctgtcgtagc   1140

aagacctcag aatctagcat aacttaggct aggtttggct agatgctttc tgggtataag   1200

ccagagtcgt atagtgcaac tttgctgtga ccttagtgaa catcccctct tgaggactac   1260

aaaaacaaac gtaacttttt aaaattatta tggagaattt tacgtaaaac aaaagtagac   1320

aggctagtct aatgaactcc catgtatcat tacccagcat caactattta tgactaatct   1380

tacctacttc tactttgtct tattgaatta attttggagc agatcttaga aatagaattt   1440

aatctataaa aatcttggtg ggctgggtac ggtggctcat gcctgtaatc ccagcacttt   1500

gggaggctga ggtgggtgga tcacctgagg tcaggagtcc aagaccagcc tggccaatgt   1560

ggtgaaactc catctcttct aaaaatacaa aaattagctg gtcttggtgg cgggcgcctg   1620

taatcccagc tacttgggag gctgaggcag gagaattgct tgaacccagg aagcagaggt   1680

tgcagtgagc tgagacggtg ccattgctct ccagcctggg cgacaagagc gaaactccgt   1740

ctcaaaaaaa aaaaagaaaa gaaaaagaaa aaaaaaatct tggtatactg gctgggcaca   1800

gtggctcaca cctaatccca gcactttggg aggctgaggc aggaggatag cttgaggctg   1860

ggagttcaaa accagcctgg gcaacatagc aagaccccat ctctaccaaa aaaaattttt   1920

ttaaagattt caggtatatt tctcaaaaag ataaggactg tcaattgtct actccccccc   1980

aacaaaggtc actaaggaaa cctgttgact aaacaaagct cattaaacct attgtagtgt   2040

agcaaaggag accatcaact tgacacagag tcttggtaat gattcaaagg gaggatgtta   2100

gagtaaggta tttataagga tttgagataa gggtccaact ggtttaaaat gagtcaaaat   2160

agggaactag tagagactga gaaagggttg tgaatagctt aggtttggta aacttaggaa   2220

atcaacagtt ttaattttaa tatggttaaa ctgattagta tttcctattt ttttatctac   2280

tgtgtaagaa gaccctataa tatatgggca ttactgagag atactgccca tatgttgtcc   2340

tcgtaagcaa ggagatattt tttatctccc atatattacc tttcaaacct ttgttacttt   2400

agtttcgaga tatagatcca gtttatgttg ttactcagta gtgaggaagt ttcttttttt   2460

tttttaaatg gctatcaagt tgtcccccca ttagttattg aaaagaccat aattttttca   2520

ctcctattca atgccatttt tattgtaaat aaactatgta catgtaaaaa aaaaaaaaaa   2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  2611


<210>  1306
<211>  150
<212>  PRT
<213>  Homosapiens

<400>  1306

Met Ala Ala Ser Gln Cys Leu Cys Cys Ser Lys Phe Leu Phe Gln Arg 
1               5                   10                  15      


Gln Asn Leu Ala Cys Phe Leu Thr Asn Pro His Cys Gly Ser Leu Val 
            20                  25                  30          


Asn Ala Asp Gly His Gly Glu Val Trp Thr Asp Trp Asn Asn Met Ser 
        35                  40                  45              


Lys Phe Phe Gln Tyr Gly Trp Arg Cys Thr Thr Asn Glu Asn Thr Tyr 
    50                  55                  60                  


Ser Asn Arg Thr Leu Met Gly Asn Trp Asn Gln Glu Arg Tyr Asp Leu 
65                  70                  75                  80  


Arg Asn Ile Val Gln Pro Lys Pro Leu Pro Ser Gln Phe Gly His Tyr 
                85                  90                  95      


Phe Glu Thr Thr Tyr Asp Thr Ser Tyr Asn Asn Lys Met Pro Leu Ser 
            100                 105                 110         


Thr His Arg Phe Lys Arg Glu Pro His Trp Phe Pro Gly His Gln Pro 
        115                 120                 125             


Glu Leu Asp Pro Pro Arg Tyr Lys Cys Thr Glu Lys Ser Thr Tyr Met 
    130                 135                 140                 


Asn Ser Tyr Ser Lys Pro 
145                 150 


<210>  1307
<211>  691
<212>  DNA
<213>  Homosapiens

<400>  1307
gacccctcac actcacctag ccaccatgga catcgccatc caccacccct ggatccgccg     60

ccccttcttt cctttccact cccccagccg cctctttgac cagttcttcg gagagcacct    120

gttggagtct gatcttttcc cgacgtctac ttccctgagt cccttctacc ttcggccacc    180

ctccttcctg cgggcaccca gctggtttga cactggactc tcagagatgc gcctggagaa    240

ggacaggttc tctgtcaacc tggatgtgaa gcacttctcc ccagaggaac tcaaagttaa    300

ggtgttggga gatgtgattg aggtgcatgg aaaacatgaa gagcgccagg atgaacatgg    360

tttcatctcc agggagttcc acaggaaata ccggatccca gctgatgtag accctctcac    420

cattacttca tccctgtcat ctgatggggt cctcactgtg aatggaccaa ggaaacaggt    480

ctctggccct gagcgcacca ttcccatcac ccgtgaagag aagcctgctg tcaccgcagc    540

ccccaagaaa tagatgccct ttcttgaatt gcatttttta aaacaagaaa gtttccccac    600

cagtgaatga aagtcttgtg actagtgctg aagcttatta atgctaaggg caggcccaaa    660

ttatcaagct aataaaatat cattcagcaa c                                   691


<210>  1308
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  1308

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro 
1               5                   10                  15      


Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu 
            20                  25                  30          


Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr 
        35                  40                  45              


Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly 
    50                  55                  60                  


Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 
                85                  90                  95      


Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 
            100                 105                 110         


Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val 
        115                 120                 125             


Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr 
    130                 135                 140                 


Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro 
145                 150                 155                 160 


Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys 
                165                 170                 175 


<210>  1309
<211>  820
<212>  DNA
<213>  Homosapiens

<400>  1309
cgctgcgcct gttggggctg cacctcggac cagggcttct gctgcatctg cagccatgtc     60

gggccgctca gtgccacatg cccacccggc caccgccgag tacgaatttg ccaacccgag    120

ccgcctgggt gagcagcgct tcggagaagg cctcctgcca gaagagatcc tgacccccac    180

actctaccat ggctactatg tccggcctcg ggccgcccca gctggggagg gcagcagggc    240

aggggcctcc gagcttaggc tcagtgaggg caagttccag gcatttctgg atgtgagcca    300

ctttacccca gacgaggtga ctgtgaggac tgtggataac ctgctggagg tgtctgcccg    360

gcacccccag cgcctggacc gccacggctt cgtgtcccga gagttctgcc gcacctatgt    420

cctgcctgct gatgtcgacc cctggcgagt ccgagctgct ctctcccatg atggcatctt    480

aaacctggaa gcacctcggg gtggccgaca tttggacaca gaggtcaatg aggtctacat    540

ctccctgctc cctgcgcctc ctgatccaga ggaagaggag gaggcagcca tagttgagcc    600

ctgattgcca cagacccagc acccagcaaa tccctctcta cctcccaagg tgatatgggc    660

agctgcccac cactccagag gtagcagcat ccttggggga agggaaaggt gcatggtcca    720

caatgtatgg tttggtccca tgggacatgt catagccttg gtttagtttt gggtggagct    780

gaataaaccc aaatttcagg gcaaaaaaaa aaaaaaaaaa                          820


<210>  1310
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  1310

Met Ser Gly Arg Ser Val Pro His Ala His Pro Ala Thr Ala Glu Tyr 
1               5                   10                  15      


Glu Phe Ala Asn Pro Ser Arg Leu Gly Glu Gln Arg Phe Gly Glu Gly 
            20                  25                  30          


Leu Leu Pro Glu Glu Ile Leu Thr Pro Thr Leu Tyr His Gly Tyr Tyr 
        35                  40                  45              


Val Arg Pro Arg Ala Ala Pro Ala Gly Glu Gly Ser Arg Ala Gly Ala 
    50                  55                  60                  


Ser Glu Leu Arg Leu Ser Glu Gly Lys Phe Gln Ala Phe Leu Asp Val 
65                  70                  75                  80  


Ser His Phe Thr Pro Asp Glu Val Thr Val Arg Thr Val Asp Asn Leu 
                85                  90                  95      


Leu Glu Val Ser Ala Arg His Pro Gln Arg Leu Asp Arg His Gly Phe 
            100                 105                 110         


Val Ser Arg Glu Phe Cys Arg Thr Tyr Val Leu Pro Ala Asp Val Asp 
        115                 120                 125             


Pro Trp Arg Val Arg Ala Ala Leu Ser His Asp Gly Ile Leu Asn Leu 
    130                 135                 140                 


Glu Ala Pro Arg Gly Gly Arg His Leu Asp Thr Glu Val Asn Glu Val 
145                 150                 155                 160 


Tyr Ile Ser Leu Leu Pro Ala Pro Pro Asp Pro Glu Glu Glu Glu Glu 
                165                 170                 175     


Ala Ala Ile Val Glu Pro 
            180         


<210>  1311
<211>  1132
<212>  DNA
<213>  Homosapiens

<400>  1311
ggaaatgcac aagcctcttg atgcataaaa acagctgggc tcccttggag acagagcgcc     60

atgggaaacc gggtctgctg cggaggaagc tggagctgcc catcaacttt ccagaagaaa    120

aagaaaagag gaagccaaac aagacggaca ctgaagccgc agccacaaca gctgcagcag    180

aatctcccaa agggccatga aacaacagga catacgtatg aacgggtgtt acagcagcaa    240

gggtctcaag agaggagtcc aggcctcatg tcggaagaca gcaacttaca ttatgctgac    300

attcaagtgt gcagccgtcc ccatgcccgg gaagtgaaac acgtgcattt agaaaacgct    360

acagagtatg cgacccttcg cttcccccag gccacacctc gctatgacag caagaacggg    420

accctggtgt gagcgcttgg gaggaaggcc cagtccatcg ttaaccacta cacctgtggg    480

ggagaaccta ctgctttggg gaattgggtg gcaacccagg gatgttgtcc acgttttaag    540

cttaaagaac tccaaagccc ctggaattgt gggcgtccca ttttctcccc tggcctctta    600

cttgccactg ttaggttgga gttaatagtt ggtttagcta tgggtggata gctaaactta    660

gctatccaca tgaggttagg tggagtgtgc agggaggtag gtcttcgacc ccaccattgt    720

tgctcctgct cttgcaaagt gcagaaagag caggtaaaaa gttagcccat aagcacgtgg    780

gctgatcttg ttggacttta attaatggta tcctttttca cacaccttaa actccaaagc    840

tgaaggggag gtgctccgga aaagcattct gagcttttac attcagacac tagggctggc    900

ttgggccatt tcctcagtgg ctgagtcagg ttccagacct taacagacaa atgggggaag    960

ggggctgagg cgtggaggaa acgctttcag gacctcaagt cagtgataac cgacagcaca   1020

gtgaggcctg gaaacttccc tcggagggac tgttggctct cgcaggtgcg gggccgctag   1080

gatcaataaa cggcctgaga aacaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           1132


<210>  1312
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  1312

Met Gly Asn Arg Val Cys Cys Gly Gly Ser Trp Ser Cys Pro Ser Thr 
1               5                   10                  15      


Phe Gln Lys Lys Lys Lys Arg Gly Ser Gln Thr Arg Arg Thr Leu Lys 
            20                  25                  30          


Pro Gln Pro Gln Gln Leu Gln Gln Asn Leu Pro Lys Gly His Glu Thr 
        35                  40                  45              


Thr Gly His Thr Tyr Glu Arg Val Leu Gln Gln Gln Gly Ser Gln Glu 
    50                  55                  60                  


Arg Ser Pro Gly Leu Met Ser Glu Asp Ser Asn Leu His Tyr Ala Asp 
65                  70                  75                  80  


Ile Gln Val Cys Ser Arg Pro His Ala Arg Glu Val Lys His Val His 
                85                  90                  95      


Leu Glu Asn Ala Thr Glu Tyr Ala Thr Leu Arg Phe Pro Gln Ala Thr 
            100                 105                 110         


Pro Arg Tyr Asp Ser Lys Asn Gly Thr Leu Val 
        115                 120             


<210>  1313
<211>  4803
<212>  DNA
<213>  Homosapiens

<400>  1313
ggggcgcagc ctgcgccgcc gggagcctcc ctcccagtgg gagatgggtt gagatgcccc     60

cgccaggggg gatgcccggc accgtgcgtc cgcggaggcc aagatgcagc ggccaggggc    120

cggcagcctg cgaggggagg cagcttccgc cggggccggg ctgctgcaca gtctgagcgg    180

ccgggactgc gcgcttcaga gcctggagca tcccagtcgc tggggccgag acgccgccgc    240

cgcagccgtt cccgctttct cccgcgagcc gggccagtag ctttgctagc tggccttccc    300

gtggaggcgt tttccagccc cagcgcgggg agacatgcct gaatttggga gcgatgtgac    360

tctcagcctc ccacttcacc cggggacgca ggcttgctga agcccaagac aggaggggga    420

ccatgggagg gacgcaagtc aaatgcctga cttcacccag tccaatccac agtgcaaaga    480

gcgagtccat tataacccag tcagaagaga aggcagattt tgtgattatt cccgctgaag    540

gaatagagaa cagaacagaa gggacagatt ctccattatc tcgagactgg cggccaggga    600

gccctggaac ctatctggag acctcatggg aagaacagct gttggaacaa caagaatatt    660

tagaaaaaga aatggaggaa gcaaagaaaa tgatatcagg actacaggcc ttactgctca    720

atggatcctt acctgaagat gaacaggaga ggcccttggc cctctgtgaa ccaggtgtca    780

atcccgagga acaactgatt ataatccaaa gtcgtctgga tcagagtatg gaggagaatc    840

aggacttaaa gaaggaactg ctgaaatgta aacaagaagc cagaaactta caggggataa    900

aggatgcctt gcagcagaga ttgactcagc aggacacatc tgttcttcag ctcaaacaag    960

agctactgag ggcaaatatg gacaaagatg agctgcacaa ccagaatgtg gatctgcaga   1020

ggaagctaga tgagaggaac cggctcttgg gagaatataa aaaagagctg gggcagaagg   1080

atcgccttct tcagcagcac caggccaagt tagaagaagc actccggaaa ctctctgatg   1140

tcagttacca ccaggtggat ctagagcgag agctagaaca caaagatgtc ctcttggctc   1200

actgtatgaa aagagaggca gatgaggcga ccaactacaa cagtcacaac tctcaaagca   1260

atggttttct ccttccaacg gcaggaaaag gagctacttc agtcagcaac agagggacca   1320

gcgacctgca gcttgttcga gatgctctcc gcagcctgcg caacagcttc agtggccacg   1380

atcctcagca ccacactatt gacagcttgg agcagggcat ttctagcctc atggagcgcc   1440

tgcatgttat ggagacgcag aagaaacaag aaagaaaggt tcgggtcaag tcacccagaa   1500

ctcaagtagg tagtgaatac cgggagtcct ggccccctaa ctcaaagttg cctcactcac   1560

agagctctcc aactgtcagc agcacctgta ctaaagtgct ctatttcact gaccggtcac   1620

ttacgccctt catggtcaat ataccaaaga ggttggagga ggtgacgtta aaggatttta   1680

aagcagctat tgatcgggaa ggaaatcacc ggtatcactt caaagcactg gatccagagt   1740

ttggcactgt caaagaggag attttccatg atgatgatgc catccctgga tgggaaggga   1800

aaattgtagc ttgggtggaa gaagaccatg gagagaatta atgccaagta tcagattgag   1860

ggcttatgga acctggtcac tccctggctg cttcactcag gaaagggaac taaaaccaga   1920

atacactaag aagtttatag tttgtgtgcc aaaacagaag cttctccaag catgatggcc   1980

acaggtcagt cctctttctg tgcctggcat atctggtact taaaattctg tccaaatgta   2040

gaccatgggt tcatctggag ttccttgtcc gtgggaacac agtgttctat tctactctga   2100

ggacaacaaa ccgaaggcct taaacgatgg ggatggatga tcccgcctct gtaggggcat   2160

ggctgctatt atctggaaat taggaattgg atgcatcatt cctgtgtgtt acagtattat   2220

tttaattggc ctcaatggtt gcagcaatca gagtcccagc gtttgtactc acagacaagg   2280

caaaggtacc agcttttctg tttctttgaa cctactgcaa accaagaata actcatgagg   2340

tggtaccaaa gatgaaagcc cagacttcag taatcttttg aaccagacgt ggatggtgct   2400

gaattgttgc ttggatggaa aaagggctgc ccatgttgtg ctacactatg ctaaaactgt   2460

aatttagtaa gaccttgggc tgcctcttct gtcttaactg gttctgcagc ttgtcctttt   2520

gcccacatag ggcctatttc atgtactgtt agttttctct ggggactctt taactttaga   2580

gccatttctt tttcttcaaa ctgatgaact tttgtttgaa aggcataagg agtgaaaagc   2640

tccttgaaaa tccaggcggg tatggaaagg tgctgctacc catatctttt tgactttctt   2700

tgtttcatga ctttaactca tggcatctcc tttgtagtaa aaggagacag accattaatt   2760

tcagcatttc tttgtgattt ataagtactg agcatgaagt acttgtctgc ccctcatttc   2820

aaggccagag ttattttcta tttatgtatt agtctaggct gatcttttag ggcacaatag   2880

aaacgatggg gcgtggagca tgagttgtga atggcaggga tcattctggg taaaaaaaac   2940

ctagaatcat ttctgatgtg caacattgtc aagtgaagaa gctaacagtt caactaccga   3000

gattatttga taacctgggt tttctcactc atccatcaag caccatcaac cagtcagcca   3060

ttattattta tatatgtatt accaaaagca gtctatctgc ctgtgacctc caatgtacac   3120

tgccaaacac aagagtagga cacatctgtt ctgggttctt gacctatctg tctccaattc   3180

atctcccctt ttcagccatt tcaacaaact actctttgga gctctgagat gacatcttgt   3240

tgttttatat agatgtatct tttaaaaata gttcacgttt ggagaattct tttgtactca   3300

tttgcttttt gtctgagaac catgtctatt tttataactg gagtgtgagt tctgtatctt   3360

ctcacattct gtatactgta tccattttct agagaaccca gtagctttta tacagtctct   3420

tcttaccacc ccttgtggtt tcagaacaag ctttatttta ttacgagtat attaatgaca   3480

actaattcct gttccaattc tacctgtttt agttgtgaag gtagttttgt gtaatccagt   3540

tgattgctcc tctggcagag agaaggagct caaaagatac ttgatgtctt tcatgtaagt   3600

ttacctggtc ttttcctatt gaagaatttt tcatcagaaa cgactgggaa agtttgggaa   3660

agtcagcaaa agaaagaatg catttcgaaa gcaaacagaa gaaaaaagta tattctcaca   3720

gtttttcccc aggaagtctg gagaaaaagt cctcatgtca ccaatttctc tgttgcatga   3780

attttagtgt tttgctataa gacagcatga gggctatcag gccaaaattc attattgtat   3840

ttccaataca gtttgtcttg aatgtctgtc tcttaaacca gtttttactt gtcagttttc   3900

tctcagcaaa cagtcttact attatgtgga atttaacttt tcagagaaaa tttccaaagt   3960

cctctacctt atttggcttt tatctgtgtc ttttggaaaa ggagctgcat ggcctcagtg   4020

cctccataaa aagcttaagt tgagttcatg ggagaacatt aagatcgttt tttttccctt   4080

ttagctcggt aatctcatgt accacaggta atgaccaagc atctctgcta gaggatgtac   4140

ctctcataac tcctgtgtaa aatgaggatc ctgttggtga tcctcattcc agtttccaaa   4200

gcgagaggag ccttctgagc agaagtatgc aagactgatt ctgtttggaa cagtttccta   4260

tttggctgca ttctaggagg cctcctgact tattcatagt attgtcgcct ggtggcattg   4320

gtgtggcgta gcttgtcctg ctacttgcta aagttctctt tctttgagaa aactgaggaa   4380

ccagaatgct tagagttcat aaaataatct ctaaaccatg ttaggttaaa acaaaatgac   4440

catctcacaa aaacgagttt agttgaatgc tcaatttctt acaaaatctt catttaaggc   4500

tgagtgtggt ggctcatgcc tgtaattcca gcactttggg aggccgaggc aggaagactg   4560

cttgagccca ggagttcaag accagcctgg gcaacatagg aagactctgt ctctacatag   4620

aaattttatt ataaaagtag ctggggatgg tggcacacac acctgtagtc ccagctactc   4680

aggaggttga ggtgggaaga ttgcttgagc ccaggagttt gaggttgcag tgagctgatc   4740

atgccactgc actctagcct aggctacaga gcaggacccc atctccaaaa aaaaaaaaaa   4800

aaa                                                                 4803


<210>  1314
<211>  472
<212>  PRT
<213>  Homosapiens

<400>  1314

Met Gly Gly Thr Gln Val Lys Cys Leu Thr Ser Pro Ser Pro Ile His 
1               5                   10                  15      


Ser Ala Lys Ser Glu Ser Ile Ile Thr Gln Ser Glu Glu Lys Ala Asp 
            20                  25                  30          


Phe Val Ile Ile Pro Ala Glu Gly Ile Glu Asn Arg Thr Glu Gly Thr 
        35                  40                  45              


Asp Ser Pro Leu Ser Arg Asp Trp Arg Pro Gly Ser Pro Gly Thr Tyr 
    50                  55                  60                  


Leu Glu Thr Ser Trp Glu Glu Gln Leu Leu Glu Gln Gln Glu Tyr Leu 
65                  70                  75                  80  


Glu Lys Glu Met Glu Glu Ala Lys Lys Met Ile Ser Gly Leu Gln Ala 
                85                  90                  95      


Leu Leu Leu Asn Gly Ser Leu Pro Glu Asp Glu Gln Glu Arg Pro Leu 
            100                 105                 110         


Ala Leu Cys Glu Pro Gly Val Asn Pro Glu Glu Gln Leu Ile Ile Ile 
        115                 120                 125             


Gln Ser Arg Leu Asp Gln Ser Met Glu Glu Asn Gln Asp Leu Lys Lys 
    130                 135                 140                 


Glu Leu Leu Lys Cys Lys Gln Glu Ala Arg Asn Leu Gln Gly Ile Lys 
145                 150                 155                 160 


Asp Ala Leu Gln Gln Arg Leu Thr Gln Gln Asp Thr Ser Val Leu Gln 
                165                 170                 175     


Leu Lys Gln Glu Leu Leu Arg Ala Asn Met Asp Lys Asp Glu Leu His 
            180                 185                 190         


Asn Gln Asn Val Asp Leu Gln Arg Lys Leu Asp Glu Arg Asn Arg Leu 
        195                 200                 205             


Leu Gly Glu Tyr Lys Lys Glu Leu Gly Gln Lys Asp Arg Leu Leu Gln 
    210                 215                 220                 


Gln His Gln Ala Lys Leu Glu Glu Ala Leu Arg Lys Leu Ser Asp Val 
225                 230                 235                 240 


Ser Tyr His Gln Val Asp Leu Glu Arg Glu Leu Glu His Lys Asp Val 
                245                 250                 255     


Leu Leu Ala His Cys Met Lys Arg Glu Ala Asp Glu Ala Thr Asn Tyr 
            260                 265                 270         


Asn Ser His Asn Ser Gln Ser Asn Gly Phe Leu Leu Pro Thr Ala Gly 
        275                 280                 285             


Lys Gly Ala Thr Ser Val Ser Asn Arg Gly Thr Ser Asp Leu Gln Leu 
    290                 295                 300                 


Val Arg Asp Ala Leu Arg Ser Leu Arg Asn Ser Phe Ser Gly His Asp 
305                 310                 315                 320 


Pro Gln His His Thr Ile Asp Ser Leu Glu Gln Gly Ile Ser Ser Leu 
                325                 330                 335     


Met Glu Arg Leu His Val Met Glu Thr Gln Lys Lys Gln Glu Arg Lys 
            340                 345                 350         


Val Arg Val Lys Ser Pro Arg Thr Gln Val Gly Ser Glu Tyr Arg Glu 
        355                 360                 365             


Ser Trp Pro Pro Asn Ser Lys Leu Pro His Ser Gln Ser Ser Pro Thr 
    370                 375                 380                 


Val Ser Ser Thr Cys Thr Lys Val Leu Tyr Phe Thr Asp Arg Ser Leu 
385                 390                 395                 400 


Thr Pro Phe Met Val Asn Ile Pro Lys Arg Leu Glu Glu Val Thr Leu 
                405                 410                 415     


Lys Asp Phe Lys Ala Ala Ile Asp Arg Glu Gly Asn His Arg Tyr His 
            420                 425                 430         


Phe Lys Ala Leu Asp Pro Glu Phe Gly Thr Val Lys Glu Glu Ile Phe 
        435                 440                 445             


His Asp Asp Asp Ala Ile Pro Gly Trp Glu Gly Lys Ile Val Ala Trp 
    450                 455                 460                 


Val Glu Glu Asp His Gly Glu Asn 
465                 470         


<210>  1315
<211>  3321
<212>  DNA
<213>  Homosapiens

<400>  1315
ttggacagcg tggggggttg gtggcactat gtggcgcgtc tgtgcgcgac gggctcagaa     60

tgtagcccca tgggcgggac tcgaggctcg gtggacggcc ttgcaggagg tacccggaac    120

tccacgagtg acctcgcgat ctggcccggc tcccgctcgt cgcaacagcg tgactacagg    180

gtatggcggg gtccgggcac tgtgcggctg gacccccagt tctggggcca cgccgcggaa    240

ccgcttactg ctgcagcttt tggggtcgcc cggccgccgc tattacagtc ttcccccgca    300

tcagaaggtt ccattgcctt ctctttcccc cacaatgcag gcaggcacca tagcccgttg    360

ggaaaaaaaa gagggggaca aaatcaatga aggtgaccta attgcagagg ttgaaactga    420

taaagccact gttggatttg agagcctgga ggagtgttat atggcaaaga tacttgttgc    480

tgaaggtacc agggatgttc ccatcggagc gatcatctgt atcacagttg gcaagcctga    540

ggatattgag gcctttaaaa attatacact ggattcctca gcagcaccta ccccacaagc    600

ggccccagca ccaacccctg ctgccactgc ttcgccacct acaccttctg ctcaggctcc    660

tggtagctca tatccccctc acatgcaggt acttcttcct gccctctctc ccaccatgac    720

catgggcaca gttcagagat gggaaaaaaa agtgggtgag aagctaagtg aaggagactt    780

actggcagag atagaaactg acaaagccac tataggtttt gaagtacagg aagaaggtta    840

tctggcaaaa atcctggtcc ctgaaggcac aagagatgtc cctctaggaa ccccactctg    900

tatcattgta gaaaaagagg cagatatatc agcatttgct gactataggc caaccgaagt    960

aacagattta aaaccacaag tgccaccacc taccccaccc ccggtggccg ctgttcctcc   1020

aactccccag cctttagctc ctacaccttc agcaccctgc ccagctactc ctgctggacc   1080

aaagggaagg gtgtttgtta gccctcttgc aaagaagttg gcagtagaga aagggattga   1140

tcttacacaa gtaaaaggga caggaccaga tggtagaatc accaagaagg atatcgactc   1200

ttttgtgcct agtaaagttg ctcctgctcc ggcagctgtt gtgcctccca caggtcctgg   1260

aatggcacca gttcctacag gtgtcttcac agatatccca atcagcaaca ttcgtcgggt   1320

tattgcacag cgattaatgc aatcaaagca aaccatacct cattattacc tttctatcga   1380

tgtaaatatg ggagaagttt tgttggtacg gaaagaactt aataagatat tagaagggag   1440

aagcaaaatt tctgtcaatg acttcatcat aaaagcttca gctttggcat gtttaaaagt   1500

tcccgaagca aattcttctt ggatggacac agttataaga caaaatcatg ttgttgatgt   1560

cagtgttgcg gtcagtactc ctgcaggact catcacacct attgtgttta atgcacatat   1620

aaaaggagtg gaaaccattg ctaatgatgt tgtttcttta gcaaccaaag caagagaggg   1680

taaactacag ccacatgaat tccagggtgg cacttttacg atctccaatt taggaatgtt   1740

tggaattaag aatttctctg ctattattaa cccacctcaa gcatgtattt tggcaattgg   1800

tgcttcagag gataaactgg tccctgcaga taatgaaaaa gggtttgatg tggctagcat   1860

gatgtctgtt acactcagtt gtgatcaccg ggtggtggat ggagcagttg gagcccagtg   1920

gcttgctgag tttagaaagt accttgaaaa acctatcact atgttgttgt aactaactca   1980

agaatttcta aactctccca ggtcacactg attcattctt aacaagatat ttatatgtta   2040

ttaaacaggt ggttcttttt attttaacca gttattttta ttattgagtc tgtccagata   2100

agttatttat aatgggcatt actgaatttt taaaatgccg attacaccca aatattgtgc   2160

acatttaata atcagacacc agatttttag ctctgtactc ctaattaagg gacatgtatg   2220

tggccttgcc tagccctttg gtgataagta cttcctctag gaaatgtacg ataggtagaa   2280

ttgtggttcc ctaaagacaa gtacataaag gtgaccctga tgaaaccttg aagttctgaa   2340

atttaactgc ctaaaatgtt ctccttagat gtgagagaaa gagaaatcag aaaaattaat   2400

tctcttgggg gaagggcttg aattgaagct ttactttaga atttagccct ggtttgaaat   2460

tttccattac atgatcttgg tttatcatcg atgggaaggg tagaaaactt caaggaaaat   2520

aagtgaaatt ttaaaagtca gcattttctt agacctcttc agctgattgt ttatttttct   2580

atgaattcct acacatggtt attcccccct acttgagata atctaaatat aaaccagcta   2640

cttgatgtaa ctgagaattt gtgtggatat ttatttaaac aaatgtgtaa ttttgagtac   2700

agaattcaac agttacctcc aaaaaagaaa cattgttaat ataatttaac agaagttgtg   2760

aaactaaaat tttctaagat taactggtag ttcattgtaa atgaacataa tgaacagaat   2820

ttatgactcc actgtggaaa atgctatcaa ataactaagg aatatatatg gaataagtgt   2880

acatatgtaa aatattgtta ctagagttag atatgtgcca aagtccattt atcccaaatc   2940

ctgtctgaaa aggaggggta cattggtaaa cattttggag tgcttaaaaa tgccaaaaac   3000

aaaatggtaa tttctacttt gataaagtaa aaaagttaaa tgtgtgtaaa aaagtgttct   3060

gtgtccttct actccagcat cgtctcatgt aaaataagaa agccctaaaa tactattgga   3120

gagaaaaaat taactaggtt gctactttat ttgcctaaat acttttttct attttgttag   3180

attttgcctt tcttttggaa ggaaggaggc gatattctgg attataaaaa tgaattggga   3240

acattatcac aattccagac tttctattaa tatttatgtg ttttaataaa cgtttgaaat   3300

taaaaaaaaa aaaaaaaaaa a                                             3321


<210>  1316
<211>  647
<212>  PRT
<213>  Homosapiens

<400>  1316

Met Trp Arg Val Cys Ala Arg Arg Ala Gln Asn Val Ala Pro Trp Ala 
1               5                   10                  15      


Gly Leu Glu Ala Arg Trp Thr Ala Leu Gln Glu Val Pro Gly Thr Pro 
            20                  25                  30          


Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val 
        35                  40                  45              


Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser 
    50                  55                  60                  


Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser 
65                  70                  75                  80  


Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu 
                85                  90                  95      


Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu 
            100                 105                 110         


Lys Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val 
        115                 120                 125             


Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr 
    130                 135                 140                 


Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly 
145                 150                 155                 160 


Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe 
                165                 170                 175     


Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala 
            180                 185                 190         


Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala 
        195                 200                 205             


Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro 
    210                 215                 220                 


Ala Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys 
225                 230                 235                 240 


Lys Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu 
                245                 250                 255     


Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu 
            260                 265                 270         


Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr 
        275                 280                 285             


Pro Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala 
    290                 295                 300                 


Asp Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Val Pro Pro 
305                 310                 315                 320 


Pro Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu 
                325                 330                 335     


Ala Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys 
            340                 345                 350         


Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu Lys 
        355                 360                 365             


Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile 
    370                 375                 380                 


Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala 
385                 390                 395                 400 


Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro 
                405                 410                 415     


Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile 
            420                 425                 430         


Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu 
        435                 440                 445             


Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu 
    450                 455                 460                 


Asn Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile 
465                 470                 475                 480 


Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser 
                485                 490                 495     


Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser 
            500                 505                 510         


Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn 
        515                 520                 525             


Ala His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu 
    530                 535                 540                 


Ala Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly 
545                 550                 555                 560 


Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe 
                565                 570                 575     


Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala 
            580                 585                 590         


Ser Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val 
        595                 600                 605             


Ala Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp 
    610                 615                 620                 


Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu 
625                 630                 635                 640 


Lys Pro Ile Thr Met Leu Leu 
                645         


<210>  1317
<211>  1079
<212>  DNA
<213>  Homosapiens

<400>  1317
ggcttaagaa aattattcac cactcataag tcatggagac atcctcaaaa ggtctgctta     60

cccaagttac tcagttttgg aacctcctag atgatctagc tcagagtgac cctgagggct    120

atgagaagtt tattcagcag cagctgaaag aagggaaaca gctctgtgct gccccagaac    180

cacagctttg tctacagacc aggattctga aaccaaaaga aaaaatactt tttatcaacc    240

tgtgtcagtg gacaaggatc ccagctcccc aatcaaccac tcatccagta cctctaactg    300

ttggcaaacc agaagataca actgagatat cagatgctta cacagtcatt gatgttgcct    360

acaatcctga tgttcttcat gcagcagaaa aggaccaagt gaaaaaaaat cagttaattc    420

agatggccat gaaatgcatt gaggagaaat tccagttcac cctctcacac tcttaccata    480

ttaccaaatt tagaataaaa ggaagcattc aaagaatgaa acaaaatctg atgggaatcc    540

aaactgattc catagattta agagaaaaaa tgagaaggga actaactctt ggacagatac    600

gaagcagtac tatgagcaat ccagatcact ttcctcaact gttactgcca aaagaccaag    660

tttcaggcaa agcagtgtgt ctgatagaag agatttccag tactgaaatc caggtggaga    720

tgaagatgcc agcctatgaa ctaaaaattg tgcatgatca cagtgagaaa cctctgaaaa    780

ttgagttgaa agttgaatta cctggtatta attctgtctc tctctgtgac cttagtgttt    840

ctgaggatga tttattgatt gaagtatctg agaagtacag attacatctg aatcttccaa    900

aacttattga tactgaaatg accacagcaa aatttatcaa agaaaaatcc acgctaatca    960

tcacaatgcc tttggtgtga aagaagagca tcatatgttt tgggttttca gtgctaaagt   1020

catgtgaatt aaaggacctt cattttggcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    1079


<210>  1318
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  1318

Met Glu Thr Ser Ser Lys Gly Leu Leu Thr Gln Val Thr Gln Phe Trp 
1               5                   10                  15      


Asn Leu Leu Asp Asp Leu Ala Gln Ser Asp Pro Glu Gly Tyr Glu Lys 
            20                  25                  30          


Phe Ile Gln Gln Gln Leu Lys Glu Gly Lys Gln Leu Cys Ala Ala Pro 
        35                  40                  45              


Glu Pro Gln Leu Cys Leu Gln Thr Arg Ile Leu Lys Pro Lys Glu Lys 
    50                  55                  60                  


Ile Leu Phe Ile Asn Leu Cys Gln Trp Thr Arg Ile Pro Ala Pro Gln 
65                  70                  75                  80  


Ser Thr Thr His Pro Val Pro Leu Thr Val Gly Lys Pro Glu Asp Thr 
                85                  90                  95      


Thr Glu Ile Ser Asp Ala Tyr Thr Val Ile Asp Val Ala Tyr Asn Pro 
            100                 105                 110         


Asp Val Leu His Ala Ala Glu Lys Asp Gln Val Lys Lys Asn Gln Leu 
        115                 120                 125             


Ile Gln Met Ala Met Lys Cys Ile Glu Glu Lys Phe Gln Phe Thr Leu 
    130                 135                 140                 


Ser His Ser Tyr His Ile Thr Lys Phe Arg Ile Lys Gly Ser Ile Gln 
145                 150                 155                 160 


Arg Met Lys Gln Asn Leu Met Gly Ile Gln Thr Asp Ser Ile Asp Leu 
                165                 170                 175     


Arg Glu Lys Met Arg Arg Glu Leu Thr Leu Gly Gln Ile Arg Ser Ser 
            180                 185                 190         


Thr Met Ser Asn Pro Asp His Phe Pro Gln Leu Leu Leu Pro Lys Asp 
        195                 200                 205             


Gln Val Ser Gly Lys Ala Val Cys Leu Ile Glu Glu Ile Ser Ser Thr 
    210                 215                 220                 


Glu Ile Gln Val Glu Met Lys Met Pro Ala Tyr Glu Leu Lys Ile Val 
225                 230                 235                 240 


His Asp His Ser Glu Lys Pro Leu Lys Ile Glu Leu Lys Val Glu Leu 
                245                 250                 255     


Pro Gly Ile Asn Ser Val Ser Leu Cys Asp Leu Ser Val Ser Glu Asp 
            260                 265                 270         


Asp Leu Leu Ile Glu Val Ser Glu Lys Tyr Arg Leu His Leu Asn Leu 
        275                 280                 285             


Pro Lys Leu Ile Asp Thr Glu Met Thr Thr Ala Lys Phe Ile Lys Glu 
    290                 295                 300                 


Lys Ser Thr Leu Ile Ile Thr Met Pro Leu Val 
305                 310                 315 


<210>  1319
<211>  3766
<212>  DNA
<213>  Homosapiens

<400>  1319
gggaagtctc ctcctttttc tcccaaacca cttcttcccc cctacccccc gccacgcgag     60

gctgcggcgc acggtatggg tgtgtttgtg tgtatttgtg tggggagggc gtttggaggg    120

aaggttaccg ggagctccga ggccgctggg gaacagggat cccggtgaca aagatgggga    180

tatttcctct gtcttccact tggaaacctc aacccccgct tcaggctccc tagatacttt    240

ctggggccca accgaaggcc gtagccatcc aaagcgttcc cagcctttct ggggagtgaa    300

acttaccccc ggggttcgtc ctagaggagc gtgagcgggg aatgcccagg tcaaccgggc    360

tgtccgaatt ccgccccggc tcagcctccg gcctcagtcc gggagagaga tctgcctgtc    420

ggtctgggct gggggaaacg cggcagtggc ctgggccaca ggtgagggca gagtaaccag    480

tgggaaggct gcgttttcac gaaggactcg ggtgaagctg cagagctgcc tttgagccct    540

gactccttgg cttcctgggt cggaggagat cttgtaatgg agtggttctt cgtctcacta    600

gcaagatgcc tgatttcctc aggatcaagg gattgaagaa tgtcccggat tccactgggg    660

aaggtcctcc tgaggaatgt catccggcac acagatgctc acaataaggt gggaggtaca    720

acctagttac ccctcaacgc ttactgaaga ttcaggagga atcagatatg tggaaaataa    780

gagaactgga aaaacagatg gaagatgctt accgggggac caaaaggaaa atgctaccca    840

gcagttcaag ccggatgcgc agtgatggtt ttgatgaaga aagtcaaaga tactattgga    900

ggccaaagaa tgaaatttct gggacactgg aagatgattt tcttaaggct aaatcctgga    960

ataaaaggtt ctatgattat gaagcaaaca tgccagacag atggggtcac agtggttata   1020

aagagttata ccctgaagaa tttgaaacag acagtagtga tcagcaagat attaccaacg   1080

ggaagaaaac atctccccag gtaaagtcat ctacccatga atcccgcaaa cacaagaagt   1140

caaagaaatc ccacaaaaaa aagcagaaaa aaaggtcaca caaaaaacag aagaaaagca   1200

aaaaggaagc cacagatata acagcagatt cctcgagtga gttctcagaa gaaactgggg   1260

cttctggtac aaggaaaggg aaacaaccac ataaacgcaa gaaaaaatcc aggaaaaagt   1320

ctctcaaaaa acctgcttta ttcttagagg cagaaagtaa cacttcacat tcagatgatt   1380

cagcatccag cagttctgag gaaagtgagg aaagagacac taagaaaacc aaaaggaaaa   1440

agagagagaa aaaagcccat acctctgtag ccaacaatga aatacaggag aggacaaaca   1500

aacgcacaaa ttggaaagta gctacagatg aaaggtctgc tgagagctca gaggatgact   1560

aaatgggaaa cacttttgtt ttccacatga ctgtggatat ttacagttct tactccttgt   1620

ggttttgcca gtgactcttg ttcagcacgg ggcctgaggt cagagctgtc ttgtgccatc   1680

tgtatgttct gacagacgtc ttgtcttcta ttttggcgtt aagcttgatc cccttttctt   1740

gttaaaaggg aatctggtat tttgttatga aggtttcttg aagagattat ttttttttgc   1800

aattaattac gtttagtgta gagtgcatat acagcaaatt aaaggaccca gaaagctgga   1860

tccaatagtg acctgggtac accaatcgga atattgaatt tggggaagtc aagggctggg   1920

atcaagaggt ggattggaac taatgccatg taggatggta tgacaaggca acactgtatt   1980

gctctctgtt tatatagcag gtgtcacaac taacttgtct ttagccttgg tgctttgatc   2040

cttctatatt ttgaccccac aggtgtggtc cggtttactt aatcaggaca tgggcctaag   2100

aacaaacctt ttcccttcat gataacatcc atagacaact tattagaagg gactagagtt   2160

tttgcaaatt tccctgctgg atggggccta tagctatact tagtatatgc ctaaacatgg   2220

taattggata gtaaatggtt ttctagttcc attgctgtat atttgcctaa atggacttgt   2280

gttcaaatta tttcttcaat tgtcatagat aatcctgtac caaatgggga agaattagga   2340

aataatcatg ttgtctaatg gtactctgga ttcagggcag caactgccat ttaaatgttg   2400

tcttgttcat ttctaaatct gttcatgaag tttaggtttt ccctgaaact aagttgaatt   2460

atttccaaaa tgaaacaggc ttctcaggga catatccact tcttcccagt ctgcctttgg   2520

attaaagcac caagcagaga ccacattaat tccctttgct atactgtgat ccttagtatg   2580

ttaattctta agaaaccaac atatcactga aagaaggctg gcagaacgca agtgcatttt   2640

tttcactgtg ggaagaaaga tcaagtgacg tattattttt tcctggttgt cacttaatgg   2700

gctgagtaaa aagcttgaaa actcagactt tcggtcttgg ttctgccact cattggttac   2760

gaggaggccc agagcaggta agttcacctt cctggcctta ctttcctgat gtgtaatacg   2820

gaattacttc acagtagcat gacagtataa gacaccagca gtagatacaa ctatgatgac   2880

attccatgag ttggtatttt tagttctaac tgctaaattt gttctcttta cgggacagat   2940

ttctaataaa gtgcttggtc ttaaaataca tggttggaca gaggtgccct atcccttaac   3000

tatgagcagg tgctaccttt tgggatattt attttaaatt ttaatacttt ggtactcaat   3060

tgtcagtgtt ccatggtgtg tatttttatt tttgggatta gtgggggtct aaagggagaa   3120

gaatagtctc taattactac ctcttaacct aaagcaatta ttttgttcct ggagcaagtt   3180

aaatctttgt tggaaggagc tttggccata tattttttag catgcattgt ttctgtgccc   3240

tgaaagtacc tgaaaggttt taagcacaga ctcaggaaaa tgtgccagta gaacaggcca   3300

tctccaggaa attggctcta tttgggtcct gaccttccct tcctcccaag ttagcaggct   3360

tgttcttttg caaggaatac acatcttgcc tttttttttt tttttttttt ttgccatgtt   3420

ttccttttct tggtcatgta taagcaataa agctgttttt tgttcttcat ctttcttaac   3480

cccaaatttt cttctatgcc ttaggcttcg atggttcttc caaccccctt aatatggctt   3540

agggtggttt ttcaaaacct acaatccccc atttgcacta ctggccatgg aacatttatt   3600

tctagtgttc ctgccaatca gagatctcta tattaaattc taaaatggga ttaaaagaag   3660

agttggagaa ttcacactta ttgagtaact gatgtcatac aacctggaat ttctgaattc   3720

caaataaata aatttcactc tttgaaaaaa aaaaaaaaaa acaaca                  3766


<210>  1320
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  1320

Met Trp Lys Ile Arg Glu Leu Glu Lys Gln Met Glu Asp Ala Tyr Arg 
1               5                   10                  15      


Gly Thr Lys Arg Lys Met Leu Pro Ser Ser Ser Ser Arg Met Arg Ser 
            20                  25                  30          


Asp Gly Phe Asp Glu Glu Ser Gln Arg Tyr Tyr Trp Arg Pro Lys Asn 
        35                  40                  45              


Glu Ile Ser Gly Thr Leu Glu Asp Asp Phe Leu Lys Ala Lys Ser Trp 
    50                  55                  60                  


Asn Lys Arg Phe Tyr Asp Tyr Glu Ala Asn Met Pro Asp Arg Trp Gly 
65                  70                  75                  80  


His Ser Gly Tyr Lys Glu Leu Tyr Pro Glu Glu Phe Glu Thr Asp Ser 
                85                  90                  95      


Ser Asp Gln Gln Asp Ile Thr Asn Gly Lys Lys Thr Ser Pro Gln Val 
            100                 105                 110         


Lys Ser Ser Thr His Glu Ser Arg Lys His Lys Lys Ser Lys Lys Ser 
        115                 120                 125             


His Lys Lys Lys Gln Lys Lys Arg Ser His Lys Lys Gln Lys Lys Ser 
    130                 135                 140                 


Lys Lys Glu Ala Thr Asp Ile Thr Ala Asp Ser Ser Ser Glu Phe Ser 
145                 150                 155                 160 


Glu Glu Thr Gly Ala Ser Gly Thr Arg Lys Gly Lys Gln Pro His Lys 
                165                 170                 175     


Arg Lys Lys Lys Ser Arg Lys Lys Ser Leu Lys Lys Pro Ala Leu Phe 
            180                 185                 190         


Leu Glu Ala Glu Ser Asn Thr Ser His Ser Asp Asp Ser Ala Ser Ser 
        195                 200                 205             


Ser Ser Glu Glu Ser Glu Glu Arg Asp Thr Lys Lys Thr Lys Arg Lys 
    210                 215                 220                 


Lys Arg Glu Lys Lys Ala His Thr Ser Val Ala Asn Asn Glu Ile Gln 
225                 230                 235                 240 


Glu Arg Thr Asn Lys Arg Thr Asn Trp Lys Val Ala Thr Asp Glu Arg 
                245                 250                 255     


Ser Ala Glu Ser Ser Glu Asp Asp 
            260                 


<210>  1321
<211>  423
<212>  DNA
<213>  Homosapiens

<400>  1321
ctgaggcgaa caatggcgga gctgggcgaa gccgatgaag cggagttgca gcgcctggtg     60

gccgccgagc agcagaaggc gcagtttact gcacaggtgc atcacttcat ggagttatgt    120

tgggataaat gtgtggagaa gccagggaat cgcctagact ctcgcactga aaattgtctc    180

tccagctgtg tagaccgctt cattgacacc actcttgcca tcaccagtcg gtttgcccag    240

attgtacaga aaggagggca gtaggccatc ccccaggaga atgacagaag caaaggactt    300

gttactaagc agatttaagg gtcagtgggg gaaggctatc aacccattgt cagatcagca    360

tcaggctgtt atcaagtctg ttggtgctaa aaagtaaaag atgaaatgtt caaaaaaaaa    420

aaa                                                                  423


<210>  1322
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  1322

Met Ala Glu Leu Gly Glu Ala Asp Glu Ala Glu Leu Gln Arg Leu Val 
1               5                   10                  15      


Ala Ala Glu Gln Gln Lys Ala Gln Phe Thr Ala Gln Val His His Phe 
            20                  25                  30          


Met Glu Leu Cys Trp Asp Lys Cys Val Glu Lys Pro Gly Asn Arg Leu 
        35                  40                  45              


Asp Ser Arg Thr Glu Asn Cys Leu Ser Ser Cys Val Asp Arg Phe Ile 
    50                  55                  60                  


Asp Thr Thr Leu Ala Ile Thr Ser Arg Phe Ala Gln Ile Val Gln Lys 
65                  70                  75                  80  


Gly Gly Gln 
            


<210>  1323
<211>  1313
<212>  DNA
<213>  Homosapiens

<400>  1323
ccaggaacga gatggcggtt ctctggaggc tgagtgccgt ttgcggtgcc ctaggaggcc     60

gagctctgtt gcttcgaact ccagtggtca gacctgctca tatctcagca tttcttcagg    120

accgacctat cccagaatgg tgtggagtgc agcacataca cttgtcaccg agccaccatt    180

ctggctccaa ggctgcatct ctccactgga ctagcgagag ggttgtcagt gttttgctcc    240

tgggtctgct tccggctgct tatttgaatc cttgctctgc gatggactat tccctggctg    300

cagccctcac tcttcatggt cactggggcc ttggacaagt tgttactgac tatgttcatg    360

gggatgcctt gcagaaagct gccaaggcag ggcttttggc actttcagct ttaacctttg    420

ctgggctttg ctatttcaac tatcacgatg tgggcatctg caaagctgtt gccatgctgt    480

ggaagctctg acctttttga cttcatactt tgaagaattg atgtatgcct ctttgcctct    540

gctttgtcat gccattaagc tcacaataag gaagaaataa cagataagtc cattggtgga    600

cagccttctt ctcttaatca caagattatt ttcagaattt aatctttgag gaaaaggttt    660

gagaggaatt atatctaagt tgtgagactg agttctatat tctggtgagt taatggggtt    720

gcctcccagc ttcttataag actcacagta taactaaaca tgatatatca gcttttgcct    780

ttcaatttat caatctctta aagagaatcc aactttatta cgattagtat atgatcaaac    840

ttccatattt gccttgggaa taatggacaa agggaaatac tcttaattca tgaataaaaa    900

ctttgcagaa aattagacag tgtttaattt tcgaaaactt ccctctctag acagtagata    960

ccacctactg atggttacat atactaggga aattttaaaa ttaggaaatg ctgatagctc   1020

atattataaa tttctaaatc ctaggaagaa acgcttggag tgcttctgaa tatacagaag   1080

ttccatttaa gggcaagttt ccccgtagat gtatcaaaat actaccaact gtaaattgag   1140

atttaattcc caaatgtatt ctacttgttc taaaacaatc tgtccacaaa tataaaacta   1200

taagtaataa attgttattt tcgcacaatg ggaatctcta atgtgaaaat gtattctatg   1260

aaaataattt tttaaataaa atgttatata ataaaagtgt cttctatgct ttt          1313


<210>  1324
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  1324

Met Ala Val Leu Trp Arg Leu Ser Ala Val Cys Gly Ala Leu Gly Gly 
1               5                   10                  15      


Arg Ala Leu Leu Leu Arg Thr Pro Val Val Arg Pro Ala His Ile Ser 
            20                  25                  30          


Ala Phe Leu Gln Asp Arg Pro Ile Pro Glu Trp Cys Gly Val Gln His 
        35                  40                  45              


Ile His Leu Ser Pro Ser His His Ser Gly Ser Lys Ala Ala Ser Leu 
    50                  55                  60                  


His Trp Thr Ser Glu Arg Val Val Ser Val Leu Leu Leu Gly Leu Leu 
65                  70                  75                  80  


Pro Ala Ala Tyr Leu Asn Pro Cys Ser Ala Met Asp Tyr Ser Leu Ala 
                85                  90                  95      


Ala Ala Leu Thr Leu His Gly His Trp Gly Leu Gly Gln Val Val Thr 
            100                 105                 110         


Asp Tyr Val His Gly Asp Ala Leu Gln Lys Ala Ala Lys Ala Gly Leu 
        115                 120                 125             


Leu Ala Leu Ser Ala Leu Thr Phe Ala Gly Leu Cys Tyr Phe Asn Tyr 
    130                 135                 140                 


His Asp Val Gly Ile Cys Lys Ala Val Ala Met Leu Trp Lys Leu 
145                 150                 155                 


<210>  1325
<211>  3414
<212>  DNA
<213>  Homosapiens

<400>  1325
agcagtttgt gcaaccagag gagcgcaggc agggttccct gctggggccc gggctgccca     60

gccatgcttt gggcactctg gccaaggtgg ctggcagaca agatgctgcc cctcctgggg    120

gcagtgctgc ttcagaagag agagaagagg ggccctctgt ggaggcactg gcggcgggaa    180

acctacccat actatgacct ccaggtgaag gtgctgaggg ccacaaacat ccggggcaca    240

gacctgctgt ccaaagccga ctgctatgtg caactgtggc tgcccacggc gtccccaagc    300

cctgcccaga ctaggatagt ggccaactgc agtgaccccg agtggaatga gaccttccac    360

taccagatcc atggtgctgt gaagaacgtc ctggagctca ccctctatga caaggacatc    420

ctgggcagcg accagctctc tctgctcctg tttgacctga gaagcctcaa gtgtggccaa    480

cctcacaaac acaccttccc actcaaccac caggattcac aagagctgca ggtggaattt    540

gttctggaga agagccaggt gcctgcatct gaagtcatca ccaacggggt tctggtggct    600

cacccctgtc tgagaatcca gggcacgctc cggggagatg ggacagcccc acgggaagag    660

tacggctcta ggcagctcca gctggcagtg cctggagcct acgagaagcc acagctcttg    720

cccctgcagc ctcccacaga gccaggcctc ccacccacct ttaccttcca cgtgaaccca    780

gtgctgagct ccaggctaca cgtggagctg atggagctgc tggcagctgt gcagagtggc    840

cccagcgcag agttggaggc tcagaccagc aagctgggcg aggggggcat cctgctctcc    900

tctctgcccc taggccagga ggaacagtgt tctgtggccc tgggggaggg ccaggaggtg    960

gctctgagca tgaaggtgga aatgagctcc ggggacctag acctacgcct tggctttgac   1020

ctctctgacg gggagcagga gtttctggac aggaggaagc aggtcgtgtc caaggccctg   1080

cagcaagtgc tgggattgag tgaggctctg gacagtggcc aggtgcctgt agtggctgtg   1140

ttgggttccg ggggtggaac ccgagccatg tcttctctgt acggcagcct ggcagggttg   1200

caggagctcg gccttctaga cactgtgacc tacctgagtg gggtctctgg gtctacctgg   1260

tgcatctcca cactctacag ggacccagcc tggtcccagg tggccttgca gggccccatt   1320

gagcgtgccc aggttcacgt ctgcagcagt aagatgggag ctttgtccac ggagcggcta   1380

cagtactaca ctcaggaact gggggtccgg gagcgcagtg gccacagcgt gtccctcatc   1440

gacctctggg gcctccttgt tgagtatctc ctgtaccagg aggagaaccc tgccaagctg   1500

tctgaccaac aggaggcggt ccgccagggt cagaaccctt accccattta caccagtgtc   1560

aacgtccgca ccaacttgag tggggaagat tttgcagagt ggtgcgagtt cacgccctat   1620

gaggttggct tccccaagta cggggcttat gttcccaccg agctcttcgg ctcagaactc   1680

ttcatgggac gattgctgca gctccagcct gaaccccgga tctgttacct gcaaggtatg   1740

tggggcagcg cctttgccac cagcctggat gagatcttcc taaagaccgc cggctcgggc   1800

ctcagcttcc tggagtggta cagaggcagt gtgaatatca cagacgactg ccagaagcct   1860

cagctgcaca acccctcgag gctgcgaacg aggctcctca ccccacaggg gcccttctcc   1920

caggctgtgc tggacatatt cacctcccgc ttcacttccg cccagagctt taacttcacc   1980

cggggtctct gcttgcacaa ggactatgtg gctggcaggg agttcgtggc ctggaaagac   2040

acacacccgg acgccttccc caaccagctc acccccatgc gggactgcct gtacctggtg   2100

gacggaggct ttgccatcaa ctctccgttc ccactggctc tgctgcctca gagagcagtg   2160

gacctcattc tgtcctttga ctattccttg gaagcccctt ttgaggtctt gaagatgaca   2220

gagaagtact gcctggaccg aggaatcccc ttccctagca tcgaggtggg ccctgaggac   2280

gtggaggagg cccgtgagtg ctatctgttt gccaaggctg aggacccccg ctcccccatt   2340

gtgctgcact tccccctggt taaccgtacc ttccgcacac acctggcccc aggtgtggag   2400

cgacaaacag ctgaggagaa ggcctttggg gactttgtca tcaacaggcc agacaccccc   2460

tatggcatga tgaacttcac ctatgagccc caggactttt atcggctggt ggccctcagt   2520

cgatacaacg tcctgaacaa cgtggagacc ttgaagtgcg ccctccagct ggctctggac   2580

cggcaccagg ctcgggagag ggcaggggcc tgaccaaggc aggaagcgga ggactgtgac   2640

agagaggaga cacactgctc atggtcaggg cttgtagagg gaggagcgat ggggactctg   2700

tgcaggatct gcttcccttc tctccaggac ctgcctcgag gtgccccagg ccccggaaag   2760

ctcttgcaga attgcagctt ggactggggc agggctctcc ttgtgtgttt ttggagaaga   2820

tgggcagtag atcgctccag ggactcttgg ggatgtaggg cagaagagaa cagcactcat   2880

ttcacagcgg ggtgtggaga gaatcaggtg agccacagag cccaccccag acacagaagg   2940

acctcagagg gcccaagtcc tcagacccac acagaacagg ggctgagggc actgagaagc   3000

cagctgtcct ccttacactg agatggaaag cagagatgca tccatccaca cttcctgcag   3060

agcggcccaa gccccaaccc cacctcgagc tcctggatgc actgctatca agaacaatga   3120

ggggctgagg ggatggccag cctatgttgc tgactccatc atcctaaccc tccttctgcc   3180

ttctggtctc ctcgtgcctc ctcccagatc acccttctct tcccagcgcc ctaaagcctg   3240

tggggtgatg tcccattctg gctgctccag gtgggagatg tgcgcgtgtc tccctgccag   3300

ttacccaggc ttcactcttc gaacctggac cacagtctct ggtgatgtgt gtagtggcca   3360

catcatgcaa atatagtctc accattccta ggagctaaaa aaaaaaaaaa aaaa         3414


<210>  1326
<211>  849
<212>  PRT
<213>  Homosapiens

<400>  1326

Met Leu Trp Ala Leu Trp Pro Arg Trp Leu Ala Asp Lys Met Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ala Val Leu Leu Gln Lys Arg Glu Lys Arg Gly Pro Leu 
            20                  25                  30          


Trp Arg His Trp Arg Arg Glu Thr Tyr Pro Tyr Tyr Asp Leu Gln Val 
        35                  40                  45              


Lys Val Leu Arg Ala Thr Asn Ile Arg Gly Thr Asp Leu Leu Ser Lys 
    50                  55                  60                  


Ala Asp Cys Tyr Val Gln Leu Trp Leu Pro Thr Ala Ser Pro Ser Pro 
65                  70                  75                  80  


Ala Gln Thr Arg Ile Val Ala Asn Cys Ser Asp Pro Glu Trp Asn Glu 
                85                  90                  95      


Thr Phe His Tyr Gln Ile His Gly Ala Val Lys Asn Val Leu Glu Leu 
            100                 105                 110         


Thr Leu Tyr Asp Lys Asp Ile Leu Gly Ser Asp Gln Leu Ser Leu Leu 
        115                 120                 125             


Leu Phe Asp Leu Arg Ser Leu Lys Cys Gly Gln Pro His Lys His Thr 
    130                 135                 140                 


Phe Pro Leu Asn His Gln Asp Ser Gln Glu Leu Gln Val Glu Phe Val 
145                 150                 155                 160 


Leu Glu Lys Ser Gln Val Pro Ala Ser Glu Val Ile Thr Asn Gly Val 
                165                 170                 175     


Leu Val Ala His Pro Cys Leu Arg Ile Gln Gly Thr Leu Arg Gly Asp 
            180                 185                 190         


Gly Thr Ala Pro Arg Glu Glu Tyr Gly Ser Arg Gln Leu Gln Leu Ala 
        195                 200                 205             


Val Pro Gly Ala Tyr Glu Lys Pro Gln Leu Leu Pro Leu Gln Pro Pro 
    210                 215                 220                 


Thr Glu Pro Gly Leu Pro Pro Thr Phe Thr Phe His Val Asn Pro Val 
225                 230                 235                 240 


Leu Ser Ser Arg Leu His Val Glu Leu Met Glu Leu Leu Ala Ala Val 
                245                 250                 255     


Gln Ser Gly Pro Ser Ala Glu Leu Glu Ala Gln Thr Ser Lys Leu Gly 
            260                 265                 270         


Glu Gly Gly Ile Leu Leu Ser Ser Leu Pro Leu Gly Gln Glu Glu Gln 
        275                 280                 285             


Cys Ser Val Ala Leu Gly Glu Gly Gln Glu Val Ala Leu Ser Met Lys 
    290                 295                 300                 


Val Glu Met Ser Ser Gly Asp Leu Asp Leu Arg Leu Gly Phe Asp Leu 
305                 310                 315                 320 


Ser Asp Gly Glu Gln Glu Phe Leu Asp Arg Arg Lys Gln Val Val Ser 
                325                 330                 335     


Lys Ala Leu Gln Gln Val Leu Gly Leu Ser Glu Ala Leu Asp Ser Gly 
            340                 345                 350         


Gln Val Pro Val Val Ala Val Leu Gly Ser Gly Gly Gly Thr Arg Ala 
        355                 360                 365             


Met Ser Ser Leu Tyr Gly Ser Leu Ala Gly Leu Gln Glu Leu Gly Leu 
    370                 375                 380                 


Leu Asp Thr Val Thr Tyr Leu Ser Gly Val Ser Gly Ser Thr Trp Cys 
385                 390                 395                 400 


Ile Ser Thr Leu Tyr Arg Asp Pro Ala Trp Ser Gln Val Ala Leu Gln 
                405                 410                 415     


Gly Pro Ile Glu Arg Ala Gln Val His Val Cys Ser Ser Lys Met Gly 
            420                 425                 430         


Ala Leu Ser Thr Glu Arg Leu Gln Tyr Tyr Thr Gln Glu Leu Gly Val 
        435                 440                 445             


Arg Glu Arg Ser Gly His Ser Val Ser Leu Ile Asp Leu Trp Gly Leu 
    450                 455                 460                 


Leu Val Glu Tyr Leu Leu Tyr Gln Glu Glu Asn Pro Ala Lys Leu Ser 
465                 470                 475                 480 


Asp Gln Gln Glu Ala Val Arg Gln Gly Gln Asn Pro Tyr Pro Ile Tyr 
                485                 490                 495     


Thr Ser Val Asn Val Arg Thr Asn Leu Ser Gly Glu Asp Phe Ala Glu 
            500                 505                 510         


Trp Cys Glu Phe Thr Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala 
        515                 520                 525             


Tyr Val Pro Thr Glu Leu Phe Gly Ser Glu Leu Phe Met Gly Arg Leu 
    530                 535                 540                 


Leu Gln Leu Gln Pro Glu Pro Arg Ile Cys Tyr Leu Gln Gly Met Trp 
545                 550                 555                 560 


Gly Ser Ala Phe Ala Thr Ser Leu Asp Glu Ile Phe Leu Lys Thr Ala 
                565                 570                 575     


Gly Ser Gly Leu Ser Phe Leu Glu Trp Tyr Arg Gly Ser Val Asn Ile 
            580                 585                 590         


Thr Asp Asp Cys Gln Lys Pro Gln Leu His Asn Pro Ser Arg Leu Arg 
        595                 600                 605             


Thr Arg Leu Leu Thr Pro Gln Gly Pro Phe Ser Gln Ala Val Leu Asp 
    610                 615                 620                 


Ile Phe Thr Ser Arg Phe Thr Ser Ala Gln Ser Phe Asn Phe Thr Arg 
625                 630                 635                 640 


Gly Leu Cys Leu His Lys Asp Tyr Val Ala Gly Arg Glu Phe Val Ala 
                645                 650                 655     


Trp Lys Asp Thr His Pro Asp Ala Phe Pro Asn Gln Leu Thr Pro Met 
            660                 665                 670         


Arg Asp Cys Leu Tyr Leu Val Asp Gly Gly Phe Ala Ile Asn Ser Pro 
        675                 680                 685             


Phe Pro Leu Ala Leu Leu Pro Gln Arg Ala Val Asp Leu Ile Leu Ser 
    690                 695                 700                 


Phe Asp Tyr Ser Leu Glu Ala Pro Phe Glu Val Leu Lys Met Thr Glu 
705                 710                 715                 720 


Lys Tyr Cys Leu Asp Arg Gly Ile Pro Phe Pro Ser Ile Glu Val Gly 
                725                 730                 735     


Pro Glu Asp Val Glu Glu Ala Arg Glu Cys Tyr Leu Phe Ala Lys Ala 
            740                 745                 750         


Glu Asp Pro Arg Ser Pro Ile Val Leu His Phe Pro Leu Val Asn Arg 
        755                 760                 765             


Thr Phe Arg Thr His Leu Ala Pro Gly Val Glu Arg Gln Thr Ala Glu 
    770                 775                 780                 


Glu Lys Ala Phe Gly Asp Phe Val Ile Asn Arg Pro Asp Thr Pro Tyr 
785                 790                 795                 800 


Gly Met Met Asn Phe Thr Tyr Glu Pro Gln Asp Phe Tyr Arg Leu Val 
                805                 810                 815     


Ala Leu Ser Arg Tyr Asn Val Leu Asn Asn Val Glu Thr Leu Lys Cys 
            820                 825                 830         


Ala Leu Gln Leu Ala Leu Asp Arg His Gln Ala Arg Glu Arg Ala Gly 
        835                 840                 845             


Ala 
    


<210>  1327
<211>  4851
<212>  DNA
<213>  Homosapiens

<400>  1327
ggggttgacg atggctgtgt tgttgaaggg cctgtagccg gggggttcct ggccggatcc     60

cggtctaccc ttagcccaga ctcgttccgg accccagccc ggcccggaac actctgggcg    120

agacggcggt ggcaactctc cccttgccgc catgcacgac gctttcgagc cagtgccgat    180

cctagaaaag ctgcctctgc aaatcgactg tctggctgcc tgggaggaat ggcttcttgt    240

gggaaccaaa caaggacatc ttcttctcta taggattcgg aaggacgttg gttgcaacag    300

atttgaagtg acactagaga aatccaataa gaacttctcc aaaaagattc agcagatcca    360

tgtggtttcc cagtttaaga ttctggtcag cttgttagaa aataacattt atgtccatga    420

cctattgaca tttcaacaaa tcactacggt ttcaaaggca aagggagcat cactgtttac    480

ttgtgacctc cagcacacag agaccggtga ggaggtgtta cggatgtgtg tggcagtaaa    540

aaagaagctg cagctctatt tctggaagga cagggaattt catgaattgc agggggactt    600

tagtgtgcca gatgtgccca agtccatggc gtggtgtgaa aattctatct gtgtgggttt    660

caagagagac tactacctaa taagggtgga tggaaagggg tccatcaaag agctctttcc    720

aacaggaaaa cagctggagc ccttagttgc acctctggca gatggaaaag tggctgtggg    780

ccaggatgat ctcaccgtgg tactcaatga ggaagggatc tgcacacaga aatgtgccct    840

gaactggacg gacataccag tggccatgga gcaccagcct ccctacatca ttgcagtgtt    900

gcctcgatat gttgagatcc gaacatttga accgaggctt ctggtccaaa gcattgaatt    960

gcaaaggccc cgtttcatta cctcaggagg atcaaacatt atctatgtgg ccagcaatca   1020

ttttgtttgg agactcatcc ctgtccccat ggcaacccaa atccaacaac ttctccagga   1080

caagcagttt gaattggctc tgcagctcgc agaaatgaaa gatgattctg acagtgaaaa   1140

gcagcaacaa attcatcaca tcaagaactt gtatgccttc aacctcttct gccagaagcg   1200

ttttgatgag tccatgcagg tctttgctaa acttggcaca gatcccaccc atgtgatggg   1260

cctgtaccct gacctgctgc ccacagacta cagaaagcag ttgcagtatc ccaacccatt   1320

gcctgtgctc tccggggctg aattggagaa ggctcactta gctctgattg actacctgac   1380

acagaaacga agtcaattgg taaagaagct gaatgactct gatcaccagt caagcacctc   1440

accgctcatg gaaggcactc ccaccatcaa atccaagaag aagctgctac aaatcatcga   1500

caccaccctg ctcaagtgct atctccatac aaatgtggcc ctggtggccc ccttgctacg   1560

cctggagaac aatcactgcc acatcgagga gagcgagcac gtgctaaaga aggctcacaa   1620

gtacagtgag cttatcatcc tgtatgagaa gaaggggctc cacgagaaag ctctgcaggt   1680

gctcgtggac cagtccaaga aagccaactc ccctctgaaa ggccacgaga ggacagtgca   1740

gtatctgcag catctgggca cagaaaacct gcatttgatt ttctcctact cagtgtgggt   1800

gctgagagac ttcccagaag atggcctgaa gatatttact gaagatctcc cggaagtgga   1860

gtctctgcca cgtgatcgag tcctcggctt cttaatagag aattttaagg gtctggctat   1920

tccttatctg gaacacatca tccatgtttg ggaggagaca ggctctcggt tccacaactg   1980

cctgatccag ctatactgtg agaaggtgca aggtctgatg aaggagtatc tcctgtcctt   2040

ccctgcaggc aaaaccccag tcccagctgg agaggaagag ggtgagctgg gagaataccg   2100

gcaaaagctc ctcatgttct tggagatttc cagctactat gatccaggcc ggctcatctg   2160

tgattttccc tttgatggcc tcttagaaga acgagctctc ctgttggggc gcatggggaa   2220

acatgaacaa gctcttttca tttatgtcca catcttgaag gatacaagga tggctgagga   2280

gtactgccac aaacactatg accgaaacaa agatggcaac aaagatgtgt atctgtccct   2340

gcttcggatg tacctgtcgc cccccagcat tcactgcctg gggccaatca agctggaact   2400

actggagcca aaagccaacc tccaggccgc tctgcaggtc ctcgagctac accacagcaa   2460

actggacacc accaaggccc tcaaccttct gccagcaaac actcagatca atgacatacg   2520

catcttcctg gaaaaggtct tggaagaaaa tgcacaaaag aaacggttca atcaagtgct   2580

caagaacctt ctccatgcag aattcctgag ggtccaggaa gagcggattt tacaccagca   2640

ggtgaagtgc atcatcacag aggagaaggt gtgcatggtg tgtaagaaga agattgggaa   2700

cagtgcattt gcaagatacc ccaatggagt ggtcgtccat tacttctgtt ccaaagaggt   2760

aaacccagct gacacttgag cccagcatcc tggggatcca gcggatggac agcttggctc   2820

tcccagagag gtgaaggagc acctggcctt aggaatcctg gctgccacca ccacaaggct   2880

ccccatttgg acattactgg ctatcttgtg ccctggaaca actctgaatt aattagactc   2940

atggtctggc attgccagct ttttaatggg aaaagagatt agttatacct tataccatta   3000

tgttgtgggc aattccagag aattcagtac ctgcttggtc aggaggatgt gcaccatctt   3060

gcctttgcac accagtcacc tgaacaagga aacttgtcac aagtgtttgt aaccatgggg   3120

ttgttcatca agggcttttc tattaagtac atgacttcac aaggaccgct cagcatggct   3180

cactggagag ttccatgaga gaacagcact caagcttctg gccgcatgga cccgatggct   3240

cgcattctgt gtagtgtttt acgtctccat ggtaactgtg ccctgcaccc ctcggtagcc   3300

gccctgttag ttttcagtct ccttttcttt ctcaccattt atcacttccc tcactgccct   3360

acccaggctt tctctcccac ttccctgact ctgggaataa ctaatattta agcaaggtaa   3420

gatgagaagc aaggggtctc agttctagga atacagtgct agttgattgt caggtatgtt   3480

gtaaatagac cctctttggc catacactcc atgcctagat gcctcggaga gcatcattct   3540

ctgcctaggc aaggccctgc atcccttgcc tcaggccggg ctgagtgtga ctgcagctcc   3600

tgaggatggg cctgccctgt ctggggtatg cgtgatccct agatacatgt tcccacagag   3660

gtgcctgctc cgtcttcgct caccagacac tcaggcaggc tggcttagtc tttgtgcgtg   3720

gcgattttgt gctctgggcc ctttctcttt ttccagccag tttccattca cttgccttac   3780

agcctgccct ggccgtcact ccccagcttt gttcagcaat ggtgtggttg gagagttgtg   3840

ctgggatagc gcaggaaggt gggtcccggc aacacgcagg ggatgagtgg acctggaact   3900

gacaatggcg tgctgccaag tgttcctgag aggtgtttag gcacagcaga ggggacgcgg   3960

ggggcaagaa cagcaggacg ctggtttaaa aataactcac cgccaaacct gtggagcagt   4020

gtggggcatc ctgccagagg tgcacaggct ggagtttcag gcactgcagg ctgatgacac   4080

acagggagag tggccctgcc tcctgtcctc cccggggttt ttgcagactc gaagtctcac   4140

tgcaccagtg tctttgatgg tggtgagggt gggtgatggt gcccagcacc aacagtttta   4200

gtggcctgtc cttgacctgc cgtggtcctt tgtaaactat ggctccatgc tgtgtgacag   4260

atcaacgtgc tgatggtaag tagactaggc ttccccaggc atgccgtccg tgggggcctg   4320

aagagacagt gagtgccatt ggccccattc gcagatgtgg gagactctgc tcaggcctgt   4380

gaggctgggc agcccttcac cagagttcgg aggagcagtg tgtggcgcca cgtcccgact   4440

ggccataccc acacagaagc agtgctgccc ggggcctcat ctgggccagc ttggactctg   4500

cttcctccag gagcagcagg gaagctctgg gccacctccc tggatagcag gaacttgacc   4560

tgccatgtgt gccctgcctt cctggccagc tgtgcttgtt atcttccatt ctcacaaact   4620

gtctttgaag caatagaata aagaatgtgt gttttctttc ctggtataca tacatgatcc   4680

catgctccca agctccattc ttccttccct caactctctg ccctccacag agctatggag   4740

aaggctggag atgaaagctt tgtagtgagg actgataaag atctcatcac tgctccttat   4800

aataaaccta ataaagcaag aaaccaagcc taaaaaaaaa aaaaaaaaaa a            4851


<210>  1328
<211>  875
<212>  PRT
<213>  Homosapiens

<400>  1328

Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu 
1               5                   10                  15      


Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr 
            20                  25                  30          


Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Gly Cys 
        35                  40                  45              


Asn Arg Phe Glu Val Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys 
    50                  55                  60                  


Lys Ile Gln Gln Ile His Val Val Ser Gln Phe Lys Ile Leu Val Ser 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Ile Tyr Val His Asp Leu Leu Thr Phe Gln Gln 
                85                  90                  95      


Ile Thr Thr Val Ser Lys Ala Lys Gly Ala Ser Leu Phe Thr Cys Asp 
            100                 105                 110         


Leu Gln His Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala 
        115                 120                 125             


Val Lys Lys Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His 
    130                 135                 140                 


Glu Leu Gln Gly Asp Phe Ser Val Pro Asp Val Pro Lys Ser Met Ala 
145                 150                 155                 160 


Trp Cys Glu Asn Ser Ile Cys Val Gly Phe Lys Arg Asp Tyr Tyr Leu 
                165                 170                 175     


Ile Arg Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly 
            180                 185                 190         


Lys Gln Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala 
        195                 200                 205             


Val Gly Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys 
    210                 215                 220                 


Thr Gln Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu 
225                 230                 235                 240 


His Gln Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile 
                245                 250                 255     


Arg Thr Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg 
            260                 265                 270         


Pro Arg Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser 
        275                 280                 285             


Asn His Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile 
    290                 295                 300                 


Gln Gln Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala 
305                 310                 315                 320 


Glu Met Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His 
                325                 330                 335     


Ile Lys Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp 
            340                 345                 350         


Glu Ser Met Gln Val Phe Ala Lys Leu Gly Thr Asp Pro Thr His Val 
        355                 360                 365             


Met Gly Leu Tyr Pro Asp Leu Leu Pro Thr Asp Tyr Arg Lys Gln Leu 
    370                 375                 380                 


Gln Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu 
                405                 410                 415     


Val Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu 
            420                 425                 430         


Met Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile 
        435                 440                 445             


Ile Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu 
    450                 455                 460                 


Val Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu 
465                 470                 475                 480 


Ser Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile 
                485                 490                 495     


Leu Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val 
            500                 505                 510         


Asp Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr 
        515                 520                 525             


Val Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe 
    530                 535                 540                 


Ser Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys 
545                 550                 555                 560 


Ile Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg 
                565                 570                 575     


Val Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr 
            580                 585                 590         


Leu Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His 
        595                 600                 605             


Asn Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly 
625                 630                 635                 640 


Glu Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe 
                645                 650                 655     


Leu Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe 
            660                 665                 670         


Pro Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met 
        675                 680                 685             


Gly Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp 
    690                 695                 700                 


Thr Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys 
705                 710                 715                 720 


Asp Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser 
                725                 730                 735     


Pro Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu 
            740                 745                 750         


Pro Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His 
        755                 760                 765             


Ser Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr 
    770                 775                 780                 


Gln Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn 
785                 790                 795                 800 


Ala Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala 
                805                 810                 815     


Glu Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys 
            820                 825                 830         


Cys Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile 
        835                 840                 845             


Gly Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr 
    850                 855                 860                 


Phe Cys Ser Lys Glu Val Asn Pro Ala Asp Thr 
865                 870                 875 


<210>  1329
<211>  2875
<212>  DNA
<213>  Homosapiens

<400>  1329
gaaatgcttt cggtaggcac tccacggctg tgaagatggc ggcggctgcg tggcttcagg     60

tgttgcctgt cattcttctg cttctgggag ctcacccgtc accactgtcg tttttcagtg    120

cgggaccggc aaccgtagct gctgccgacc ggtccaaatg gcacattccg ataccgtcgg    180

ggaaaaatta ttttagtttt ggaaagatcc tcttcagaaa taccactatc ttcctgaagt    240

ttgatggaga accttgtgac ctgtctttga atataacctg gtatctgaaa agcgctgatt    300

gttacaatga aatctataac ttcaaggcag aagaagtaga gttgtatttg gaaaaactta    360

aggaaaaaag aggcttgtct gggaaatatc aaacatcatc aaaattgttc cagaactgca    420

gtgaactctt taaaacacag accttttctg gagattttat gcatcgactg cctcttttag    480

gagaaaaaca ggaggctaag gagaatggaa caaaccttac ctttattgga gacaaaaccg    540

caatgcatga accattgcaa acttggcaag atgcaccata catttttatt gtacatattg    600

gcatttcatc ctcaaaggaa tcatcaaaag aaaattcact gagtaatctt tttaccatga    660

ctgttgaagt gaagggtccc tatgaatacc tcacacttga agactatccc ttgatgattt    720

ttttcatggt gatgtgtatt gtatatgtcc tgtttggtgt tctgtggctg gcatggtctg    780

cctgctactg gagagatctc ctgagaattc agttttggat tggtgctgtc atcttcctgg    840

gaatgcttga gaaagctgtc ttctatgcgg aatttcagaa tatccgatac aaaggagaat    900

ctgtccaggg tgctttgatc cttgcagagc tgctttcagc agtgaaacgc tcactggctc    960

gaaccctggt catcatagtc agtctgggat atggcatcgt caagccacgc cttggagtca   1020

ctcttcataa ggttgtagta gcaggagccc tctatctttt gttctctggc atggaagggg   1080

tcctcagagt tactggggcc cagactgatc ttgcttcctt ggcctttatc cccttggctt   1140

tcctagacac tgccttgtgc tggtggatat ttattagcct gactcaaaca atgaagctat   1200

taaaacttcg gaggaacatt gtaaaactct ctttgtatcg gcatttcacc aacacgctta   1260

ttttggcagt ggcagcatcc attgtgttta tcatctggac aaccatgaag ttcagaatag   1320

tgacatgtca gtcggactgg cgggagctgt gggtagacga tgccatctgg cgcttgctgt   1380

tctccatgat cctctttgtc atcatggttc tctggcgacc atctgcaaac aaccagaggt   1440

ttgccttttc accattgtct gaggaagagg aggaggatga acaaaaggag cctatgctga   1500

aagaaagctt tgaaggaatg aaaatgagaa gtaccaaaca agaacccaat ggaaatagta   1560

aagttaacaa agcacaggaa gatgatttga agtgggtaga agagaatgtt ccttcttctg   1620

tgacagatgt agcacttcca gcccttctgg attcagatga ggaacgaatg atcacacact   1680

ttgaaaggtc caaaatggag taaggaatgg gaagatttgc agttaaagat ggctaccatc   1740

agggaagaga tcagcatctg tgtcagtctt ctgtacggct ccatgggatt aaaggaagca   1800

atgacatcct gatctgttcc ttgatctttg ggcattggag ttggcgagag gtgtcagaac   1860

aaagagaaca tcttactgaa aacaagttca taagatgaga aaaatctacg agcttcttat   1920

ttacaacact gctgccccct ttcctcccag actctgacat ggatgttcat gcaacttaag   1980

tgtgttgttc ctgaactttc tgtaatgttt cattttttaa atctgacaaa ctaaaaagtt   2040

taacgtcttc taaaagattg tcatcaacac cataatatgt aatctccagg agcaactgcc   2100

tgtaattttt atttatttag ggagttacat aggtgatggg ggaaattgtt aactaccttt   2160

cattttcctg ggaagtcaag gttacatctt gcagaggttg ttttgagaaa aaagggccct   2220

tctgagttaa ggagccatag ttctatcaat gatcaaaaga aaaaaaaaaa aaagagaaac   2280

tgttgcagta tgattcagat catttaaaaa agcaaaatca agtgcaattt tgtttacaaa   2340

tggtgtatat taaagatttt tctatttcag atgtacttta aagagaaata ttagcttaac   2400

tcttttgaca tctgctattg tgacacatcc cattgctggc aatgtggtgc acactccgaa   2460

acttttaact actgttttgt aagcctccaa gggtggcatt gcagggtcct taggcaatgt   2520

tttgtttgcc tttatgcaga gaggtgctcc aagtgctgtg attgagcacc gtgctagagg   2580

aactgtaatg cttcagaagt tgtagcttat acaaaggaaa caggtcctgc tggcttaatt   2640

taaacagtta ttgcatgaag tagcgtggag gccctggact gctgctcgtt ctttaggatg   2700

gactgttctg gtatctggta ttggtttaga gactgttaat aagggacatc acaaggtgat   2760

gggattcatt tgaagcactc tatttctgtt ttaatgtttt atccaatttt gccttcccaa   2820

gatttttgtt ctacataaaa agttcatgcc actttttaat ataaaaaaat ttaac        2875


<210>  1330
<211>  555
<212>  PRT
<213>  Homosapiens

<400>  1330

Met Ala Ala Ala Ala Trp Leu Gln Val Leu Pro Val Ile Leu Leu Leu 
1               5                   10                  15      


Leu Gly Ala His Pro Ser Pro Leu Ser Phe Phe Ser Ala Gly Pro Ala 
            20                  25                  30          


Thr Val Ala Ala Ala Asp Arg Ser Lys Trp His Ile Pro Ile Pro Ser 
        35                  40                  45              


Gly Lys Asn Tyr Phe Ser Phe Gly Lys Ile Leu Phe Arg Asn Thr Thr 
    50                  55                  60                  


Ile Phe Leu Lys Phe Asp Gly Glu Pro Cys Asp Leu Ser Leu Asn Ile 
65                  70                  75                  80  


Thr Trp Tyr Leu Lys Ser Ala Asp Cys Tyr Asn Glu Ile Tyr Asn Phe 
                85                  90                  95      


Lys Ala Glu Glu Val Glu Leu Tyr Leu Glu Lys Leu Lys Glu Lys Arg 
            100                 105                 110         


Gly Leu Ser Gly Lys Tyr Gln Thr Ser Ser Lys Leu Phe Gln Asn Cys 
        115                 120                 125             


Ser Glu Leu Phe Lys Thr Gln Thr Phe Ser Gly Asp Phe Met His Arg 
    130                 135                 140                 


Leu Pro Leu Leu Gly Glu Lys Gln Glu Ala Lys Glu Asn Gly Thr Asn 
145                 150                 155                 160 


Leu Thr Phe Ile Gly Asp Lys Thr Ala Met His Glu Pro Leu Gln Thr 
                165                 170                 175     


Trp Gln Asp Ala Pro Tyr Ile Phe Ile Val His Ile Gly Ile Ser Ser 
            180                 185                 190         


Ser Lys Glu Ser Ser Lys Glu Asn Ser Leu Ser Asn Leu Phe Thr Met 
        195                 200                 205             


Thr Val Glu Val Lys Gly Pro Tyr Glu Tyr Leu Thr Leu Glu Asp Tyr 
    210                 215                 220                 


Pro Leu Met Ile Phe Phe Met Val Met Cys Ile Val Tyr Val Leu Phe 
225                 230                 235                 240 


Gly Val Leu Trp Leu Ala Trp Ser Ala Cys Tyr Trp Arg Asp Leu Leu 
                245                 250                 255     


Arg Ile Gln Phe Trp Ile Gly Ala Val Ile Phe Leu Gly Met Leu Glu 
            260                 265                 270         


Lys Ala Val Phe Tyr Ala Glu Phe Gln Asn Ile Arg Tyr Lys Gly Glu 
        275                 280                 285             


Ser Val Gln Gly Ala Leu Ile Leu Ala Glu Leu Leu Ser Ala Val Lys 
    290                 295                 300                 


Arg Ser Leu Ala Arg Thr Leu Val Ile Ile Val Ser Leu Gly Tyr Gly 
305                 310                 315                 320 


Ile Val Lys Pro Arg Leu Gly Val Thr Leu His Lys Val Val Val Ala 
                325                 330                 335     


Gly Ala Leu Tyr Leu Leu Phe Ser Gly Met Glu Gly Val Leu Arg Val 
            340                 345                 350         


Thr Gly Ala Gln Thr Asp Leu Ala Ser Leu Ala Phe Ile Pro Leu Ala 
        355                 360                 365             


Phe Leu Asp Thr Ala Leu Cys Trp Trp Ile Phe Ile Ser Leu Thr Gln 
    370                 375                 380                 


Thr Met Lys Leu Leu Lys Leu Arg Arg Asn Ile Val Lys Leu Ser Leu 
385                 390                 395                 400 


Tyr Arg His Phe Thr Asn Thr Leu Ile Leu Ala Val Ala Ala Ser Ile 
                405                 410                 415     


Val Phe Ile Ile Trp Thr Thr Met Lys Phe Arg Ile Val Thr Cys Gln 
            420                 425                 430         


Ser Asp Trp Arg Glu Leu Trp Val Asp Asp Ala Ile Trp Arg Leu Leu 
        435                 440                 445             


Phe Ser Met Ile Leu Phe Val Ile Met Val Leu Trp Arg Pro Ser Ala 
    450                 455                 460                 


Asn Asn Gln Arg Phe Ala Phe Ser Pro Leu Ser Glu Glu Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Gln Lys Glu Pro Met Leu Lys Glu Ser Phe Glu Gly Met Lys 
                485                 490                 495     


Met Arg Ser Thr Lys Gln Glu Pro Asn Gly Asn Ser Lys Val Asn Lys 
            500                 505                 510         


Ala Gln Glu Asp Asp Leu Lys Trp Val Glu Glu Asn Val Pro Ser Ser 
        515                 520                 525             


Val Thr Asp Val Ala Leu Pro Ala Leu Leu Asp Ser Asp Glu Glu Arg 
    530                 535                 540                 


Met Ile Thr His Phe Glu Arg Ser Lys Met Glu 
545                 550                 555 


<210>  1331
<211>  4603
<212>  DNA
<213>  Homosapiens

<400>  1331
gactcattgc gtacacgccc tcaccgccgc ccagtttcgg ttcctaacaa aagcacgttc     60

ctcatcagcc acccataatc aagacaaatt tgccaaataa atcattgtag aaacgctagt    120

ttgggcctga aaaattccag gagcaagagt caagatttgt cactccatga gaatctggag    180

gggactccct tcccagaaac ttgacgatga agtactggtt gtaattttag aaagacaccc    240

aatcggcttt tttaaaagat cgcccagggc ccttgtcctg agagctggga gctggtcgga    300

gtgacagaga agccatggaa gcagcagtga aagaggaaat aagtcttgaa gatgaagctg    360

tagataaaaa cattttcaga gactgtaaca agatcgcatt ttacaggcgt cagaaacagt    420

ggctttccaa gaagtccacc tatcaggcat tattggattc agtcacaaca gatgaagaca    480

gcaccaggtt ccaaatcatc aatgaagcaa gtaaggttcc tctcctggct gaaatttatg    540

gtatagaagg aaacattttc aggcttaaaa ttaatgaaga gactcctcta aaacccagat    600

ttgaagttcc ggatgtcctc acaagcaagc caagcactgt aaggctgatt tcatgctctg    660

gggacacagg cagtctgata ttggcagatg gaaaaggaga cctgaagtgc catatcacag    720

caaacccatt caaggtagac ttggtgtctg aagaagaggt tgtgattagc ataaattccc    780

tgggccaatt atactttgag catctacaga ttcttcacaa acaaagagct gctaaagaaa    840

atgaggagga gacatcagtg gacacctctc aggaaaatca agaagatctg ggcctgtggg    900

aagagaaatt tggaaaattt gtggatatca aagctaatgg cccttcttct attggtttgg    960

atttctcctt gcatggattt gagcatcttt atgggatccc acaacatgca gaatcacacc   1020

aacttaaaaa tactggtgat ggagatgctt accgtcttta taacctggat gtctatggat   1080

accaaatata tgataaaatg ggcatttatg gttcagtacc ttatctcctg gcccacaaac   1140

tgggcagaac tataggtatt ttctggctga atgcctcgga aacactggtg gagatcaata   1200

cagagcctgc agtagagtac acactgaccc agatgggccc agttgctgct aaacaaaagg   1260

tcagatctcg cactcatgtg cactggatgt cagagagtgg catcattgat gtttttctgc   1320

tgacaggacc tacaccttct gatgtcttca aacagtactc acaccttaca ggcacacaag   1380

ccatgccccc tcttttctct ttgggatacc accagtgccg ctggaactat gaagatgagc   1440

aggatgtaaa agcagtggat gcagggtttg atgagcatga cattccttat gatgccatgt   1500

ggctggacat agagcacact gagggcaaga ggtacttcac ctgggacaaa aacagattcc   1560

caaaccccaa gaggatgcaa gagctgctca ggagcaaaaa gcgtaagctt gtggtcatca   1620

gtgatcccca catcaagatt gatcctgact actcagtata tgtgaaggcc aaagatcagg   1680

gcttctttgt gaagaatcag gaaggggaag actttgaagg ggtgtgttgg ccaggtctct   1740

cctcttacct ggatttcacc aatcccaagg tcagagagtg gtattcaagt ctttttgctt   1800

tccctgttta tcagggatct acggacatcc tcttcctttg gaatgacatg aatgagcctt   1860

ctgtctttag agggccagag caaaccatgc agaagaatgc cattcatcat ggcaattggg   1920

agcacagaga gctccacaac atctacggtt tttatcatca aatggctact gcagaaggac   1980

tgataaaacg atctaaaggg aaggagagac cctttgttct tacacgttct ttctttgctg   2040

gatcacaaaa gtatggtgcc gtgtggacag gcgacaacac agcagaatgg agcaacttga   2100

aaatttctat cccaatgtta ctcactctca gcattactgg gatctctttt tgcggagctg   2160

acataggcgg gttcattggg aatccagaga cagagctgct agtgcgttgg taccaggctg   2220

gagcctacca gcccttcttc cgtggccatg ccaccatgaa caccaagcga cgagagccct   2280

ggctctttgg ggaggaacac acccgactca tccgagaagc catcagagag cgctatggcc   2340

tcctgccata ttggtattct ctgttctacc atgcacacgt ggcttcccaa cctgtcatga   2400

ggcctctgtg ggtagagttc cctgatgaac taaagacttt tgatatggaa gatgaataca   2460

tgctggggag tgcattattg gttcatccag tcacagaacc aaaagccacc acagttgatg   2520

tgtttcttcc aggatcaaat gaggtctggt atgactataa gacatttgct cattgggaag   2580

gagggtgtac tgtaaagatc ccagtagcct tggacactat tccagtgttt cagcgaggtg   2640

gaagtgtgat accaataaag acaactgtag gaaaatccac aggctggatg actgaatcct   2700

cctatggact ccgggttgct ctaagcacta agggttcttc agtgggtgag ttatatcttg   2760

atgatggcca ttcattccaa tacctccacc agaagcaatt tttgcacagg aagttttcat   2820

tctgttccag tgttctgatc aatagttttg ctgaccagag gggtcattat cccagcaagt   2880

gtgtggtgga gaagatcttg gtcttaggct tcaggaagga gccatcttct gtgactaccc   2940

actcatctga tggtaaagat cagcctgtgg cttttacgta ttgtgccaaa acatccatcc   3000

tgagcctgga gaagctctca ctcaacattg ccactgactg ggaggtccgc atcatatgac   3060

aaagaactgc ccctggtgat gtgagcaggg acctgcctgc ccctttcaac ctttcccctc   3120

accttttttg agatttttgc tgcaatctgt ttgccttccc tgaatcaaaa taatctttca   3180

ttcgtcacca ttatactaat gaacaataga tttcatgttt caaaatttca gattttacat   3240

gttaagatgt actaacaata ttccttgtat caaacatctc cttttctccc tgatacatag   3300

ccctgagaca tttatagcgt tcaggagtct tctattgctt ccattccttc agcagggctg   3360

cgtgggtctg ttttaacgtg ggccaagcct acctgggcag cccatttgcc agggcttgcc   3420

tcaggccatg cagcattggc gctctggctg cagcagctga gttgctcaag gccagtgtcc   3480

aagtggacag cagcctctgg tactcccccc agttatcttc cacccacatg gactgggcag   3540

agcagccctc ttctgtgtgc actgcatacg ctgcagccgt gggagttatt ctcccctaga   3600

gatcgacttg gcagcacgaa ggattctttt ctctttcatg cttctcaggc tcaatagttt   3660

ctaattaatc ttaaaatcca tgtcttttac attgtttttt taattaagtg ctgtttacta   3720

accaaataat atttataaca tgagtaagct ataattaata acaatgaaat aaatacccat   3780

gtacccacca ctggacttca gaagtagaac tcatgactgg gactaggatg aggcaaggga   3840

gaccctggcc ttgggcacaa aatgtaaggg atgccaaaaa aatacagtaa tcaaagtaag   3900

taatatttca atccaatatt tttaaaaatc agaattaatg caaaaaaaac catgatgaac   3960

aaaatattaa aatttaaaat aaagacagga ttagtattac tgagttttcc ttttgtccca   4020

ggctctaata tggcttggca tggggcagaa cattacaaca taccagtcgt gtcatggtgc   4080

ccaaggctcc acagacctca gtggctccct gctgcctgcc acagcatctg ttttagcagc   4140

ctcgactcct cagcactcct cagcacacac ctcttcttat caggcttcct ccacttagca   4200

acttgctaac ggccacctct gtgccttctg atccctgggc gccaatatcc tcctgccctt   4260

accatccttc caggcccaac ttaaatccca ctttcccatg aagcctaact gcgtgaacac   4320

ccctaccccc atacccatta gcagtgattt tgcccttccc cgtaatgctg tcccacttat   4380

aactgtgctc tacttagcat tctcagggat cataccttaa tgttttcagt atgtctgcgt   4440

tctcctacta gattgtatgt ccctcaagag catgttctgt ttctcttctg tctgacagag   4500

cactattata cctgactttc agtaactgtt agctgtgatt agttagctgg tggatttaat   4560

tgattaaaaa attacgattg aatgtaaaaa aaaaaaaaaa aaa                     4603


<210>  1332
<211>  914
<212>  PRT
<213>  Homosapiens

<400>  1332

Met Glu Ala Ala Val Lys Glu Glu Ile Ser Leu Glu Asp Glu Ala Val 
1               5                   10                  15      


Asp Lys Asn Ile Phe Arg Asp Cys Asn Lys Ile Ala Phe Tyr Arg Arg 
            20                  25                  30          


Gln Lys Gln Trp Leu Ser Lys Lys Ser Thr Tyr Gln Ala Leu Leu Asp 
        35                  40                  45              


Ser Val Thr Thr Asp Glu Asp Ser Thr Arg Phe Gln Ile Ile Asn Glu 
    50                  55                  60                  


Ala Ser Lys Val Pro Leu Leu Ala Glu Ile Tyr Gly Ile Glu Gly Asn 
65                  70                  75                  80  


Ile Phe Arg Leu Lys Ile Asn Glu Glu Thr Pro Leu Lys Pro Arg Phe 
                85                  90                  95      


Glu Val Pro Asp Val Leu Thr Ser Lys Pro Ser Thr Val Arg Leu Ile 
            100                 105                 110         


Ser Cys Ser Gly Asp Thr Gly Ser Leu Ile Leu Ala Asp Gly Lys Gly 
        115                 120                 125             


Asp Leu Lys Cys His Ile Thr Ala Asn Pro Phe Lys Val Asp Leu Val 
    130                 135                 140                 


Ser Glu Glu Glu Val Val Ile Ser Ile Asn Ser Leu Gly Gln Leu Tyr 
145                 150                 155                 160 


Phe Glu His Leu Gln Ile Leu His Lys Gln Arg Ala Ala Lys Glu Asn 
                165                 170                 175     


Glu Glu Glu Thr Ser Val Asp Thr Ser Gln Glu Asn Gln Glu Asp Leu 
            180                 185                 190         


Gly Leu Trp Glu Glu Lys Phe Gly Lys Phe Val Asp Ile Lys Ala Asn 
        195                 200                 205             


Gly Pro Ser Ser Ile Gly Leu Asp Phe Ser Leu His Gly Phe Glu His 
    210                 215                 220                 


Leu Tyr Gly Ile Pro Gln His Ala Glu Ser His Gln Leu Lys Asn Thr 
225                 230                 235                 240 


Gly Asp Gly Asp Ala Tyr Arg Leu Tyr Asn Leu Asp Val Tyr Gly Tyr 
                245                 250                 255     


Gln Ile Tyr Asp Lys Met Gly Ile Tyr Gly Ser Val Pro Tyr Leu Leu 
            260                 265                 270         


Ala His Lys Leu Gly Arg Thr Ile Gly Ile Phe Trp Leu Asn Ala Ser 
        275                 280                 285             


Glu Thr Leu Val Glu Ile Asn Thr Glu Pro Ala Val Glu Tyr Thr Leu 
    290                 295                 300                 


Thr Gln Met Gly Pro Val Ala Ala Lys Gln Lys Val Arg Ser Arg Thr 
305                 310                 315                 320 


His Val His Trp Met Ser Glu Ser Gly Ile Ile Asp Val Phe Leu Leu 
                325                 330                 335     


Thr Gly Pro Thr Pro Ser Asp Val Phe Lys Gln Tyr Ser His Leu Thr 
            340                 345                 350         


Gly Thr Gln Ala Met Pro Pro Leu Phe Ser Leu Gly Tyr His Gln Cys 
        355                 360                 365             


Arg Trp Asn Tyr Glu Asp Glu Gln Asp Val Lys Ala Val Asp Ala Gly 
    370                 375                 380                 


Phe Asp Glu His Asp Ile Pro Tyr Asp Ala Met Trp Leu Asp Ile Glu 
385                 390                 395                 400 


His Thr Glu Gly Lys Arg Tyr Phe Thr Trp Asp Lys Asn Arg Phe Pro 
                405                 410                 415     


Asn Pro Lys Arg Met Gln Glu Leu Leu Arg Ser Lys Lys Arg Lys Leu 
            420                 425                 430         


Val Val Ile Ser Asp Pro His Ile Lys Ile Asp Pro Asp Tyr Ser Val 
        435                 440                 445             


Tyr Val Lys Ala Lys Asp Gln Gly Phe Phe Val Lys Asn Gln Glu Gly 
    450                 455                 460                 


Glu Asp Phe Glu Gly Val Cys Trp Pro Gly Leu Ser Ser Tyr Leu Asp 
465                 470                 475                 480 


Phe Thr Asn Pro Lys Val Arg Glu Trp Tyr Ser Ser Leu Phe Ala Phe 
                485                 490                 495     


Pro Val Tyr Gln Gly Ser Thr Asp Ile Leu Phe Leu Trp Asn Asp Met 
            500                 505                 510         


Asn Glu Pro Ser Val Phe Arg Gly Pro Glu Gln Thr Met Gln Lys Asn 
        515                 520                 525             


Ala Ile His His Gly Asn Trp Glu His Arg Glu Leu His Asn Ile Tyr 
    530                 535                 540                 


Gly Phe Tyr His Gln Met Ala Thr Ala Glu Gly Leu Ile Lys Arg Ser 
545                 550                 555                 560 


Lys Gly Lys Glu Arg Pro Phe Val Leu Thr Arg Ser Phe Phe Ala Gly 
                565                 570                 575     


Ser Gln Lys Tyr Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu Trp 
            580                 585                 590         


Ser Asn Leu Lys Ile Ser Ile Pro Met Leu Leu Thr Leu Ser Ile Thr 
        595                 600                 605             


Gly Ile Ser Phe Cys Gly Ala Asp Ile Gly Gly Phe Ile Gly Asn Pro 
    610                 615                 620                 


Glu Thr Glu Leu Leu Val Arg Trp Tyr Gln Ala Gly Ala Tyr Gln Pro 
625                 630                 635                 640 


Phe Phe Arg Gly His Ala Thr Met Asn Thr Lys Arg Arg Glu Pro Trp 
                645                 650                 655     


Leu Phe Gly Glu Glu His Thr Arg Leu Ile Arg Glu Ala Ile Arg Glu 
            660                 665                 670         


Arg Tyr Gly Leu Leu Pro Tyr Trp Tyr Ser Leu Phe Tyr His Ala His 
        675                 680                 685             


Val Ala Ser Gln Pro Val Met Arg Pro Leu Trp Val Glu Phe Pro Asp 
    690                 695                 700                 


Glu Leu Lys Thr Phe Asp Met Glu Asp Glu Tyr Met Leu Gly Ser Ala 
705                 710                 715                 720 


Leu Leu Val His Pro Val Thr Glu Pro Lys Ala Thr Thr Val Asp Val 
                725                 730                 735     


Phe Leu Pro Gly Ser Asn Glu Val Trp Tyr Asp Tyr Lys Thr Phe Ala 
            740                 745                 750         


His Trp Glu Gly Gly Cys Thr Val Lys Ile Pro Val Ala Leu Asp Thr 
        755                 760                 765             


Ile Pro Val Phe Gln Arg Gly Gly Ser Val Ile Pro Ile Lys Thr Thr 
    770                 775                 780                 


Val Gly Lys Ser Thr Gly Trp Met Thr Glu Ser Ser Tyr Gly Leu Arg 
785                 790                 795                 800 


Val Ala Leu Ser Thr Lys Gly Ser Ser Val Gly Glu Leu Tyr Leu Asp 
                805                 810                 815     


Asp Gly His Ser Phe Gln Tyr Leu His Gln Lys Gln Phe Leu His Arg 
            820                 825                 830         


Lys Phe Ser Phe Cys Ser Ser Val Leu Ile Asn Ser Phe Ala Asp Gln 
        835                 840                 845             


Arg Gly His Tyr Pro Ser Lys Cys Val Val Glu Lys Ile Leu Val Leu 
    850                 855                 860                 


Gly Phe Arg Lys Glu Pro Ser Ser Val Thr Thr His Ser Ser Asp Gly 
865                 870                 875                 880 


Lys Asp Gln Pro Val Ala Phe Thr Tyr Cys Ala Lys Thr Ser Ile Leu 
                885                 890                 895     


Ser Leu Glu Lys Leu Ser Leu Asn Ile Ala Thr Asp Trp Glu Val Arg 
            900                 905                 910         


Ile Ile 
        


<210>  1333
<211>  3316
<212>  DNA
<213>  Homosapiens

<400>  1333
cactctcttt ctctctccct ctggcatgca tgctgctggt aggagacccc caagtcaaca     60

ttgcttcaga aatcctttag cactcatttc tcaggagaac ttatggcttc agaatcacag    120

ctcggttttt aagatggaca taacctgtac gaccttctga tgggctttca actttgaact    180

ggatgtggac acttttctct cagatgacag aattactcca acttcccctt tgcagttgct    240

tcctttcctt gaaggtagct gtatcttatt ttctttaaaa agctttttct tccaaagcca    300

cttgccatgc cgaccgtcat tagcgcatct gtggctccaa ggacagcggc tgagccccgg    360

tccccagggc cagttcctca cccggcccag agcaaggcca ctgaggctgg gggtggaaac    420

ccaagtggca tctattcagc catcatcagc cgcaattttc ctattatcgg agtgaaagag    480

aagacattcg agcaacttca caagaaatgt ctagaaaaga aagttcttta tgtggaccct    540

gagttcccac cggatgagac ctctctcttt tatagccaga agttccccat ccagttcgtc    600

tggaagagac ctccggaaat ttgcgagaat ccccgattta tcattgatgg agccaacaga    660

actgacatct gtcaaggaga gctaggggac tgctggtttc tcgcagccat tgcctgcctg    720

accctgaacc agcaccttct tttccgagtc ataccccatg atcaaagttt catcgaaaac    780

tacgcaggga tcttccactt ccagttctgg cgctatggag agtgggtgga cgtggttata    840

gatgactgcc tgccaacgta caacaatcaa ctggttttca ccaagtccaa ccaccgcaat    900

gagttctgga gtgctctgct ggagaaggct tatgctaagc tccatggttc ctacgaagct    960

ctgaaaggtg ggaacaccac agaggccatg gaggacttca caggaggggt ggcagagttt   1020

tttgagatca gggatgctcc tagtgacatg tacaagatca tgaagaaagc catcgagaga   1080

ggctccctca tgggctgctc cattgatgat ggcacgaaca tgacctatgg aacctctcct   1140

tctggtctga acatggggga gttgattgca cggatggtaa ggaatatgga taactcactg   1200

ctccaggact cagacctcga ccccagaggc tcagatgaaa gaccgacccg gacaatcatt   1260

ccggttcagt atgagacaag aatggcctgc gggctggtca gaggtcacgc ctactctgtc   1320

acggggctgg atgaggtccc gttcaaaggt gagaaagtga agctggtgcg gctgcggaat   1380

ccgtggggcc aggtggagtg gaacggttct tggagtgata gatggaagga ctggagcttt   1440

gtggacaaag atgagaaggc ccgtctgcag caccaggtca ctgaggatgg agagttctgg   1500

atgtcctatg aggatttcat ctaccatttc acaaagttgg agatctgcaa cctcacggcc   1560

gatgctctgc agtctgacaa gcttcagacc tggacagtgt ctgtgaacga gggccgctgg   1620

gtacggggtt gctctgccgg aggctgccgc aacttcccag atactttctg gaccaaccct   1680

cagtaccgtc tgaagctcct ggaggaggac gatgaccctg atgactcgga ggtgatttgc   1740

agcttcctgg tggccctgat gcagaagaac cggcggaagg accggaagct aggggccagt   1800

ctcttcacca ttggcttcgc catctacgag gttcccaaag agatgcacgg gaacaagcag   1860

cacctgcaga aggacttctt cctgtacaac gcctccaagg ccaggagcaa aacctacatc   1920

aacatgcggg aggtgtccca gcgcttccgc ctgcctccca gcgagtacgt catcgtgccc   1980

tccacctacg agccccacca ggagggggaa ttcatcctcc gggtcttctc tgaaaagagg   2040

aacctctctg aggaagttga aaataccatc tccgtggatc ggccagtgaa aaagaaaaaa   2100

accaagccca tcatcttcgt ttcggacaga gcaaacagca acaaggagct gggtgtggac   2160

caggagtcag aggagggcaa aggcaaaaca agccctgata agcaaaagca gtccccacag   2220

ccacagcctg gcagctctga tcaggaaagt gaggaacagc aacaattccg gaacattttc   2280

aagcagatag caggagatga catggagatc tgtgcagatg agctcaagaa ggtccttaac   2340

acagtcgtga acaaacacaa ggacctgaag acacacgggt tcacactgga gtcctgccgt   2400

agcatgattg cgctcatgga tacagatggc tctggaaagc tcaacctgca ggagttccac   2460

cacctctgga acaagattaa ggcctggcag aaaattttca aacactatga cacagaccag   2520

tccggcacca tcaacagcta cgagatgcga aatgcagtca acgacgcagg attccacctc   2580

aacaaccagc tctatgacat cattaccatg cggtacgcag acaaacacat gaacatcgac   2640

tttgacagtt tcatctgctg cttcgttagg ctggagggca tgttcagagc ttttcatgca   2700

tttgacaagg atggagatgg tatcatcaag ctcaacgttc tggagtggct gcagctcacc   2760

atgtatgcct gaaccaggct ggcctcatcc aaagccatgc aggatcactc aggatttcag   2820

tttcaccctc tatttccaaa gccatttacc tcaaaggacc cagcagctac acccctacag   2880

gcttccaggc acctcatcag tcatgctcct cctccatttt accccctacc catccttgat   2940

cggtcatgcc tagcctgacc ctttagtaaa gcaatgaggt aggaagaaca aacccttgtc   3000

cctttgccat gtggaggaaa gtgcctgcct ctggtccgag ccgcctcggt tctgaagcga   3060

gtgctcctgc ttaccttgct ctaggctgtc tgcagaagca cctgccggtg gcactcagca   3120

cctccttgtg ctagagccct ccatcacctt cacgctgtcc caccatgggc caggaaccaa   3180

accagcactg ggttctactg ctgtggggta aactaactca gtggaatagg gctggttact   3240

ttgggctgtc caactcataa gtttggctgc attttgaaaa aagctgatct aaataaaggc   3300

atgtgtatgg ctggtc                                                   3316


<210>  1334
<211>  821
<212>  PRT
<213>  Homosapiens

<400>  1334

Met Pro Thr Val Ile Ser Ala Ser Val Ala Pro Arg Thr Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Thr 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
    210                 215                 220                 


Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Thr Asn Met 
            260                 265                 270         


Thr Tyr Gly Thr Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
        275                 280                 285             


Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
    290                 295                 300                 


Asp Pro Arg Gly Ser Asp Glu Arg Pro Thr Arg Thr Ile Ile Pro Val 
305                 310                 315                 320 


Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                325                 330                 335     


Ser Val Thr Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        355                 360                 365             


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
    370                 375                 380                 


Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
385                 390                 395                 400 


Tyr Glu Asp Phe Ile Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
                405                 410                 415     


Thr Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
            420                 425                 430         


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
        435                 440                 445             


Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
    450                 455                 460                 


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
465                 470                 475                 480 


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                485                 490                 495     


Ala Ser Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
            500                 505                 510         


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
        515                 520                 525             


Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
    530                 535                 540                 


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
545                 550                 555                 560 


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                565                 570                 575     


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
            580                 585                 590         


Pro Val Lys Lys Lys Lys Thr Lys Pro Ile Ile Phe Val Ser Asp Arg 
        595                 600                 605             


Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
    610                 615                 620                 


Lys Gly Lys Thr Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
625                 630                 635                 640 


Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
                645                 650                 655     


Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
            660                 665                 670         


Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His Lys Asp Leu Lys 
        675                 680                 685             


Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
    690                 695                 700                 


Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
705                 710                 715                 720 


Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Thr 
                725                 730                 735     


Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
            740                 745                 750         


Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Thr Met 
        755                 760                 765             


Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
    770                 775                 780                 


Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
785                 790                 795                 800 


Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
                805                 810                 815     


Leu Thr Met Tyr Ala 
            820     


<210>  1335
<211>  1661
<212>  DNA
<213>  Homosapiens

<400>  1335
ccctcctcca cgcttacagc cacacacaca gtcacacaga cgcgttctga gggtggctgc     60

ccgcttggga tggaggaatc acttccctca gaacccagcc aagtcctcta ggcctccttg    120

ggggtccttc cagcctgagg ggcttcggag ctgaggagca gctgttctga tgcacgggaa    180

caagcagcac ctgcagaagg acttcttcct gtacaacgcc tccaaggcca ggagcaaaac    240

ctacatcaac atgcgggagg tgtcccagcg cttccgcctg cctcccagcg agtacgtcat    300

cgtgccctcc acctacgagc cccaccagga gggggaattc atcctccggg tcttctctga    360

aaagaggaac ctctctgagg aagttgaaaa taccatctcc gtggatcggc cagtgaaaaa    420

gaaaaaaacc aagcccatca tcttcgtttc ggacagagca aacagcaaca aggagctggg    480

tgtggaccag gagtcagagg agggcaaagg caaaacaagc cctgataagc aaaagcagtc    540

cccacagcca cagcctggca gctctgatca ggaaagtgag gaacagcaac aattccggaa    600

cattttcaag cagatagcag gagatgacat ggagatctgt gcagatgagc tcaagaaggt    660

ccttaacaca gtcgtgaaca aacacaagga cctgaagaca cacgggttca cactggagtc    720

ctgccgtagc atgattgcgc tcatggatac agatggctct ggaaagctca acctgcagga    780

gttccaccac ctctggaaca agattaaggc ctggcagaaa attttcaaac actatgacac    840

agaccagtcc ggcaccatca acagctacga gatgcgaaat gcagtcaacg acgcaggatt    900

ccacctcaac aaccagctct atgacatcat taccatgcgg tacgcagaca aacacatgaa    960

catcgacttt gacagtttca tctgctgctt cgttaggctg gagggcatgt tcagagcttt   1020

tcatgcattt gacaaggatg gagatggtat catcaagctc aacgttctgg agtggctgca   1080

gctcaccatg tatgcctgaa ccaggctggc ctcatccaaa gccatgcagg atcactcagg   1140

atttcagttt caccctctat ttccaaagcc atttacctca aaggacccag cagctacacc   1200

cctacaggct tccaggcacc tcatcagtca tgctcctcct ccattttacc ccctacccat   1260

ccttgatcgg tcatgcctag cctgaccctt tagtaaagca atgaggtagg aagaacaaac   1320

ccttgtccct ttgccatgtg gaggaaagtg cctgcctctg gtccgagccg cctcggttct   1380

gaagcgagtg ctcctgctta ccttgctcta ggctgtctgc agaagcacct gccggtggca   1440

ctcagcacct ccttgtgcta gagccctcca tcaccttcac gctgtcccac catgggccag   1500

gaaccaaacc agcactgggt tctactgctg tggggtaaac taactcagtg gaatagggct   1560

ggttactttg ggctgtccaa ctcataagtt tggctgcatt ttgaaaaaag ctgatctaaa   1620

taaaggcatg tgtatggctg gtcaaaaaaa aaaaaaaaaa a                       1661


<210>  1336
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  1336

Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
1               5                   10                  15      


Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
            20                  25                  30          


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
        35                  40                  45              


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
    50                  55                  60                  


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
65                  70                  75                  80  


Pro Val Lys Lys Lys Lys Thr Lys Pro Ile Ile Phe Val Ser Asp Arg 
                85                  90                  95      


Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
            100                 105                 110         


Lys Gly Lys Thr Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
        115                 120                 125             


Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
    130                 135                 140                 


Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
145                 150                 155                 160 


Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His Lys Asp Leu Lys 
                165                 170                 175     


Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
            180                 185                 190         


Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
        195                 200                 205             


Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Thr 
    210                 215                 220                 


Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
225                 230                 235                 240 


Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Thr Met 
                245                 250                 255     


Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
            260                 265                 270         


Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
        275                 280                 285             


Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
    290                 295                 300                 


Leu Thr Met Tyr Ala 
305                 


<210>  1337
<211>  3298
<212>  DNA
<213>  Homosapiens

<400>  1337
cactctcttt ctctctccct ctggcatgca tgctgctggt aggagacccc caagtcaaca     60

ttgcttcaga aatcctttag cactcatttc tcaggagaac ttatggcttc agaatcacag    120

ctcggttttt aagatggaca taacctgtac gaccttctga tgggctttca actttgaact    180

ggatgtggac acttttctct cagatgacag aattactcca acttcccctt tgcagttgct    240

tcctttcctt gaaggtagct gtatcttatt ttctttaaaa agctttttct tccaaagcca    300

cttgccatgc cgaccgtcat tagcgcatct gtggctccaa ggacagcggc tgagccccgg    360

tccccagggc cagttcctca cccggcccag agcaaggcca ctgaggctgg gggtggaaac    420

ccaagtggca tctattcagc catcatcagc cgcaattttc ctattatcgg agtgaaagag    480

aagacattcg agcaacttca caagaaatgt ctagaaaaga aagttcttta tgtggaccct    540

gagttcccac cggatgagac ctctctcttt tatagccaga agttccccat ccagttcgtc    600

tggaagagac ctccggaaat ttgcgagaat ccccgattta tcattgatgg agccaacaga    660

actgacatct gtcaaggaga gctaggggac tgctggtttc tcgcagccat tgcctgcctg    720

accctgaacc agcaccttct tttccgagtc ataccccatg atcaaagttt catcgaaaac    780

tacgcaggga tcttccactt ccagttctgg cgctatggag agtgggtgga cgtggttata    840

gatgactgcc tgccaacgta caacaatcaa ctggttttca ccaagtccaa ccaccgcaat    900

gagttctgga gtgctctgct ggagaaggct tatgctaagc tccatggttc ctacgaagct    960

ctgaaaggtg ggaacaccac agaggccatg gaggacttca caggaggggt ggcagagttt   1020

tttgagatca gggatgctcc tagtgacatg tacaagatca tgaagaaagc catcgagaga   1080

ggctccctca tgggctgctc cattgatgat ggcacgaaca tgacctatgg aacctctcct   1140

tctggtctga acatggggga gttgattgca cggatggtaa ggaatatgga taactcactg   1200

ctccaggact cagacctcga ccccagaggc tcagatgaaa gaccgacccg gacaatcatt   1260

ccggttcagt atgagacaag aatggcctgc gggctggtca gaggtcacgc ctactctgtc   1320

acggggctgg atgaggtccc gttcaaaggt gagaaagtga agctggtgcg gctgcggaat   1380

ccgtggggcc aggtggagtg gaacggttct tggagtgata gatggaagga ctggagcttt   1440

gtggacaaag atgagaaggc ccgtctgcag caccaggtca ctgaggatgg agagttctgg   1500

atgtcctatg aggatttcat ctaccatttc acaaagttgg agatctgcaa cctcacggcc   1560

gatgctctgc agtctgacaa gcttcagacc tggacagtgt ctgtgaacga gggccgctgg   1620

gtacggggtt gctctgccgg aggctgccgc aacttcccag atactttctg gaccaaccct   1680

cagtaccgtc tgaagctcct ggaggaggac gatgaccctg atgactcgga ggtgatttgc   1740

agcttcctgg tggccctgat gcagaagaac cggcggaagg accggaagct aggggccagt   1800

ctcttcacca ttggcttcgc catctacgag gttcccaaag agatgcacgg gaacaagcag   1860

cacctgcaga aggacttctt cctgtacaac gcctccaagg ccaggagcaa aacctacatc   1920

aacatgcggg aggtgtccca gcgcttccgc ctgcctccca gcgagtacgt catcgtgccc   1980

tccacctacg agccccacca ggagggggaa ttcatcctcc gggtcttctc tgaaaagagg   2040

aacctctctg aggaagttga aaataccatc tccgtggatc ggccagtgcc catcatcttc   2100

gtttcggaca gagcaaacag caacaaggag ctgggtgtgg accaggagtc agaggagggc   2160

aaaggcaaaa caagccctga taagcaaaag cagtccccac agccacagcc tggcagctct   2220

gatcaggaaa gtgaggaaca gcaacaattc cggaacattt tcaagcagat agcaggagat   2280

gacatggaga tctgtgcaga tgagctcaag aaggtcctta acacagtcgt gaacaaacac   2340

aaggacctga agacacacgg gttcacactg gagtcctgcc gtagcatgat tgcgctcatg   2400

gatacagatg gctctggaaa gctcaacctg caggagttcc accacctctg gaacaagatt   2460

aaggcctggc agaaaatttt caaacactat gacacagacc agtccggcac catcaacagc   2520

tacgagatgc gaaatgcagt caacgacgca ggattccacc tcaacaacca gctctatgac   2580

atcattacca tgcggtacgc agacaaacac atgaacatcg actttgacag tttcatctgc   2640

tgcttcgtta ggctggaggg catgttcaga gcttttcatg catttgacaa ggatggagat   2700

ggtatcatca agctcaacgt tctggagtgg ctgcagctca ccatgtatgc ctgaaccagg   2760

ctggcctcat ccaaagccat gcaggatcac tcaggatttc agtttcaccc tctatttcca   2820

aagccattta cctcaaagga cccagcagct acacccctac aggcttccag gcacctcatc   2880

agtcatgctc ctcctccatt ttacccccta cccatccttg atcggtcatg cctagcctga   2940

ccctttagta aagcaatgag gtaggaagaa caaacccttg tccctttgcc atgtggagga   3000

aagtgcctgc ctctggtccg agccgcctcg gttctgaagc gagtgctcct gcttaccttg   3060

ctctaggctg tctgcagaag cacctgccgg tggcactcag cacctccttg tgctagagcc   3120

ctccatcacc ttcacgctgt cccaccatgg gccaggaacc aaaccagcac tgggttctac   3180

tgctgtgggg taaactaact cagtggaata gggctggtta ctttgggctg tccaactcat   3240

aagtttggct gcattttgaa aaaagctgat ctaaataaag gcatgtgtat ggctggtc     3298


<210>  1338
<211>  815
<212>  PRT
<213>  Homosapiens

<400>  1338

Met Pro Thr Val Ile Ser Ala Ser Val Ala Pro Arg Thr Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Thr 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
    210                 215                 220                 


Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Thr Asn Met 
            260                 265                 270         


Thr Tyr Gly Thr Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
        275                 280                 285             


Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
    290                 295                 300                 


Asp Pro Arg Gly Ser Asp Glu Arg Pro Thr Arg Thr Ile Ile Pro Val 
305                 310                 315                 320 


Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                325                 330                 335     


Ser Val Thr Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        355                 360                 365             


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
    370                 375                 380                 


Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
385                 390                 395                 400 


Tyr Glu Asp Phe Ile Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
                405                 410                 415     


Thr Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
            420                 425                 430         


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
        435                 440                 445             


Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
    450                 455                 460                 


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
465                 470                 475                 480 


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                485                 490                 495     


Ala Ser Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
            500                 505                 510         


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
        515                 520                 525             


Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
    530                 535                 540                 


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
545                 550                 555                 560 


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                565                 570                 575     


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
            580                 585                 590         


Pro Val Pro Ile Ile Phe Val Ser Asp Arg Ala Asn Ser Asn Lys Glu 
        595                 600                 605             


Leu Gly Val Asp Gln Glu Ser Glu Glu Gly Lys Gly Lys Thr Ser Pro 
    610                 615                 620                 


Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln Pro Gly Ser Ser Asp Gln 
625                 630                 635                 640 


Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala 
                645                 650                 655     


Gly Asp Asp Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn 
            660                 665                 670         


Thr Val Val Asn Lys His Lys Asp Leu Lys Thr His Gly Phe Thr Leu 
        675                 680                 685             


Glu Ser Cys Arg Ser Met Ile Ala Leu Met Asp Thr Asp Gly Ser Gly 
    690                 695                 700                 


Lys Leu Asn Leu Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala 
705                 710                 715                 720 


Trp Gln Lys Ile Phe Lys His Tyr Asp Thr Asp Gln Ser Gly Thr Ile 
                725                 730                 735     


Asn Ser Tyr Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu 
            740                 745                 750         


Asn Asn Gln Leu Tyr Asp Ile Ile Thr Met Arg Tyr Ala Asp Lys His 
        755                 760                 765             


Met Asn Ile Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu 
    770                 775                 780                 


Gly Met Phe Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile 
785                 790                 795                 800 


Ile Lys Leu Asn Val Leu Glu Trp Leu Gln Leu Thr Met Tyr Ala 
                805                 810                 815 


<210>  1339
<211>  3040
<212>  DNA
<213>  Homosapiens

<400>  1339
cactctcttt ctctctccct ctggcatgca tgctgctggt aggagacccc caagtcaaca     60

ttgcttcaga aatcctttag cactcatttc tcaggagaac ttatggcttc agaatcacag    120

ctcggttttt aagatggaca taacctgtac gaccttctga tgggctttca actttgaact    180

ggatgtggac acttttctct cagatgacag aattactcca acttcccctt tgcagttgct    240

tcctttcctt gaaggtagct gtatcttatt ttctttaaaa agctttttct tccaaagcca    300

cttgccatgc cgaccgtcat tagcgcatct gtggctccaa ggacagcggc tgagccccgg    360

tccccagggc cagttcctca cccggcccag agcaaggcca ctgaggctgg gggtggaaac    420

ccaagtggca tctattcagc catcatcagc cgcaattttc ctattatcgg agtgaaagag    480

aagacattcg agcaacttca caagaaatgt ctagaaaaga aagttcttta tgtggaccct    540

gagttcccac cggatgagac ctctctcttt tatagccaga agttccccat ccagttcgtc    600

tggaagagac ctccggaaat ttgcgagaat ccccgattta tcattgatgg agccaacaga    660

actgacatct gtcaaggaga gctaggggac tgctggtttc tcgcagccat tgcctgcctg    720

accctgaacc agcaccttct tttccgagtc ataccccatg atcaaagttt catcgaaaac    780

tacgcaggga tcttccactt ccagttctgg cgctatggag agtgggtgga cgtggttata    840

gatgactgcc tgccaacgta caacaatcaa ctggttttca ccaagtccaa ccaccgcaat    900

gagttctgga gtgctctgct ggagaaggct tatgctaagc tccatggttc ctacgaagct    960

ctgaaaggtg ggaacaccac agaggccatg gaggacttca caggaggggt ggcagagttt   1020

tttgagatca gggatgctcc tagtgacatg tacaagatca tgaagaaagc catcgagaga   1080

ggctccctca tgggctgctc cattgataca atcattccgg ttcagtatga gacaagaatg   1140

gcctgcgggc tggtcagagg tcacgcctac tctgtcacgg ggctggatga ggtcccgttc   1200

aaaggtgaga aagtgaagct ggtgcggctg cggaatccgt ggggccaggt ggagtggaac   1260

ggttcttgga gtgatagatg gaaggactgg agctttgtgg acaaagatga gaaggcccgt   1320

ctgcagcacc aggtcactga ggatggagag ttctggatgt cctatgagga tttcatctac   1380

catttcacaa agttggagat ctgcaacctc acggccgatg ctctgcagtc tgacaagctt   1440

cagacctgga cagtgtctgt gaacgagggc cgctgggtac ggggttgctc tgccggaggc   1500

tgccgcaact tcccagatac tttctggacc aaccctcagt accgtctgaa gctcctggag   1560

gaggacgatg accctgatga ctcggaggtg atttgcagct tcctggtggc cctgatgcag   1620

aagaaccggc ggaaggaccg gaagctaggg gccagtctct tcaccattgg cttcgccatc   1680

tacgaggttc ccaaagagat gcacgggaac aagcagcacc tgcagaagga cttcttcctg   1740

tacaacgcct ccaaggccag gagcaaaacc tacatcaaca tgcgggaggt gtcccagcgc   1800

ttccgcctgc ctcccagcga gtacgtcatc gtgccctcca cctacgagcc ccaccaggag   1860

ggggaattca tcctccgggt cttctctgaa aagaggaacc tctctgagga agttgaaaat   1920

accatctccg tggatcggcc agtgccacag cctggcagct ctgatcagga aagtgaggaa   1980

cagcaacaat tccggaacat tttcaagcag atagcaggag atgacatgga gatctgtgca   2040

gatgagctca agaaggtcct taacacagtc gtgaacaaac acaaggacct gaagacacac   2100

gggttcacac tggagtcctg ccgtagcatg attgcgctca tggatacaga tggctctgga   2160

aagctcaacc tgcaggagtt ccaccacctc tggaacaaga ttaaggcctg gcagaaaatt   2220

ttcaaacact atgacacaga ccagtccggc accatcaaca gctacgagat gcgaaatgca   2280

gtcaacgacg caggattcca cctcaacaac cagctctatg acatcattac catgcggtac   2340

gcagacaaac acatgaacat cgactttgac agtttcatct gctgcttcgt taggctggag   2400

ggcatgttca gagcttttca tgcatttgac aaggatggag atggtatcat caagctcaac   2460

gttctggagt ggctgcagct caccatgtat gcctgaacca ggctggcctc atccaaagcc   2520

atgcaggatc actcaggatt tcagtttcac cctctatttc caaagccatt tacctcaaag   2580

gacccagcag ctacacccct acaggcttcc aggcacctca tcagtcatgc tcctcctcca   2640

ttttaccccc tacccatcct tgatcggtca tgcctagcct gaccctttag taaagcaatg   2700

aggtaggaag aacaaaccct tgtccctttg ccatgtggag gaaagtgcct gcctctggtc   2760

cgagccgcct cggttctgaa gcgagtgctc ctgcttacct tgctctaggc tgtctgcaga   2820

agcacctgcc ggtggcactc agcacctcct tgtgctagag ccctccatca ccttcacgct   2880

gtcccaccat gggccaggaa ccaaaccagc actgggttct actgctgtgg ggtaaactaa   2940

ctcagtggaa tagggctggt tactttgggc tgtccaactc ataagtttgg ctgcattttg   3000

aaaaaagctg atctaaataa aggcatgtgt atggctggtc                         3040


<210>  1340
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  1340

Met Pro Thr Val Ile Ser Ala Ser Val Ala Pro Arg Thr Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Thr 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
    210                 215                 220                 


Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Thr Ile Ile Pro Val 
            260                 265                 270         


Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
        275                 280                 285             


Ser Val Thr Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
    290                 295                 300                 


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
305                 310                 315                 320 


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
                325                 330                 335     


Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
            340                 345                 350         


Tyr Glu Asp Phe Ile Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
        355                 360                 365             


Thr Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
    370                 375                 380                 


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
385                 390                 395                 400 


Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
                405                 410                 415     


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
            420                 425                 430         


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
        435                 440                 445             


Ala Ser Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
    450                 455                 460                 


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
465                 470                 475                 480 


Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
                485                 490                 495     


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
            500                 505                 510         


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
        515                 520                 525             


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
    530                 535                 540                 


Pro Val Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln 
545                 550                 555                 560 


Gln Phe Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile 
                565                 570                 575     


Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His 
            580                 585                 590         


Lys Asp Leu Lys Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met 
        595                 600                 605             


Ile Ala Leu Met Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu 
    610                 615                 620                 


Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys 
625                 630                 635                 640 


His Tyr Asp Thr Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg 
                645                 650                 655     


Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp 
            660                 665                 670         


Ile Ile Thr Met Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp 
        675                 680                 685             


Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe 
    690                 695                 700                 


His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu 
705                 710                 715                 720 


Glu Trp Leu Gln Leu Thr Met Tyr Ala 
                725                 


<210>  1341
<211>  1291
<212>  DNA
<213>  Homosapiens

<400>  1341
cataatcctg accctgagcc agtgccaggt ctccaagtgc cttctgaatg accacaggcg     60

attggtttta gtggtaggtg tgtggggatc tgttctggtc atctggatgc tggtcatcgg    120

tgtgcagtat tgatcaggac ctgcaaaccc aaaagcttat gggagctggc acgtcaccca    180

cagcctggca gctctgatca ggaaagtgag gaacagcaac aattccggaa cattttcaag    240

cagatagcag gagatgacat ggagatctgt gcagatgagc tcaagaaggt ccttaacaca    300

gtcgtgaaca aacacaagga cctgaagaca cacgggttca cactggagtc ctgccgtagc    360

atgattgcgc tcatggatac agatggctct ggaaagctca acctgcagga gttccaccac    420

ctctggaaca agattaaggc ctggcagaaa attttcaaac actatgacac agaccagtcc    480

ggcaccatca acagctacga gatgcgaaat gcagtcaacg acgcaggatt ccacctcaac    540

aaccagctct atgacatcat taccatgcgg tacgcagaca aacacatgaa catcgacttt    600

gacagtttca tctgctgctt cgttaggctg gagggcatgt tcagagcttt tcatgcattt    660

gacaaggatg gagatggtat catcaagctc aacgttctgg agtggctgca gctcaccatg    720

tatgcctgaa ccaggctggc ctcatccaaa gccatgcagg atcactcagg atttcagttt    780

caccctctat ttccaaagcc atttacctca aaggacccag cagctacacc cctacaggct    840

tccaggcacc tcatcagtca tgctcctcct ccattttacc ccctacccat ccttgatcgg    900

tcatgcctag cctgaccctt tagtaaagca atgaggtagg aagaacaaac ccttgtccct    960

ttgccatgtg gaggaaagtg cctgcctctg gtccgagccg cctcggttct gaagcgagtg   1020

ctcctgctta ccttgctcta ggctgtctgc agaagcacct gccggtggca ctcagcacct   1080

ccttgtgcta gagccctcca tcaccttcac gctgtcccac catgggccag gaaccaaacc   1140

agcactgggt tctactgctg tggggtaaac taactcagtg gaatagggct ggttactttg   1200

ggctgtccaa ctcataagtt tggctgcatt ttgaaaaaag ctgatctaaa taaaggcatg   1260

tgtatggctg gtcaaaaaaa aaaaaaaaaa a                                  1291


<210>  1342
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  1342

Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Thr Val Val 
1               5                   10                  15      


Asn Lys His Lys Asp Leu Lys Thr His Gly Phe Thr Leu Glu Ser Cys 
            20                  25                  30          


Arg Ser Met Ile Ala Leu Met Asp Thr Asp Gly Ser Gly Lys Leu Asn 
        35                  40                  45              


Leu Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys 
    50                  55                  60                  


Ile Phe Lys His Tyr Asp Thr Asp Gln Ser Gly Thr Ile Asn Ser Tyr 
65                  70                  75                  80  


Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln 
                85                  90                  95      


Leu Tyr Asp Ile Ile Thr Met Arg Tyr Ala Asp Lys His Met Asn Ile 
            100                 105                 110         


Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe 
        115                 120                 125             


Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu 
    130                 135                 140                 


Asn Val Leu Glu Trp Leu Gln Leu Thr Met Tyr Ala 
145                 150                 155     


<210>  1343
<211>  1309
<212>  DNA
<213>  Homosapiens

<400>  1343
cataatcctg accctgagcc agtgccaggt ctccaagtgc cttctgaatg accacaggcg     60

attggtttta gtggtaggtg tgtggggatc tgttctggtc atctggatgc tggtcatcgg    120

tgtgcagtat tgatcaggac ctgcaaaccc aaaagcttat gggagctggc acgtcacaaa    180

aagaaaaaaa ccaagccaca gcctggcagc tctgatcagg aaagtgagga acagcaacaa    240

ttccggaaca ttttcaagca gatagcagga gatgacatgg agatctgtgc agatgagctc    300

aagaaggtcc ttaacacagt cgtgaacaaa cacaaggacc tgaagacaca cgggttcaca    360

ctggagtcct gccgtagcat gattgcgctc atggatacag atggctctgg aaagctcaac    420

ctgcaggagt tccaccacct ctggaacaag attaaggcct ggcagaaaat tttcaaacac    480

tatgacacag accagtccgg caccatcaac agctacgaga tgcgaaatgc agtcaacgac    540

gcaggattcc acctcaacaa ccagctctat gacatcatta ccatgcggta cgcagacaaa    600

cacatgaaca tcgactttga cagtttcatc tgctgcttcg ttaggctgga gggcatgttc    660

agagcttttc atgcatttga caaggatgga gatggtatca tcaagctcaa cgttctggag    720

tggctgcagc tcaccatgta tgcctgaacc aggctggcct catccaaagc catgcaggat    780

cactcaggat ttcagtttca ccctctattt ccaaagccat ttacctcaaa ggacccagca    840

gctacacccc tacaggcttc caggcacctc atcagtcatg ctcctcctcc attttacccc    900

ctacccatcc ttgatcggtc atgcctagcc tgacccttta gtaaagcaat gaggtaggaa    960

gaacaaaccc ttgtcccttt gccatgtgga ggaaagtgcc tgcctctggt ccgagccgcc   1020

tcggttctga agcgagtgct cctgcttacc ttgctctagg ctgtctgcag aagcacctgc   1080

cggtggcact cagcacctcc ttgtgctaga gccctccatc accttcacgc tgtcccacca   1140

tgggccagga accaaaccag cactgggttc tactgctgtg gggtaaacta actcagtgga   1200

atagggctgg ttactttggg ctgtccaact cataagtttg gctgcatttt gaaaaaagct   1260

gatctaaata aaggcatgtg tatggctggt caaaaaaaaa aaaaaaaaa               1309


<210>  1344
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  1344

Met Glu Ile Cys Ala Asp Glu Leu Lys Lys Val Leu Asn Thr Val Val 
1               5                   10                  15      


Asn Lys His Lys Asp Leu Lys Thr His Gly Phe Thr Leu Glu Ser Cys 
            20                  25                  30          


Arg Ser Met Ile Ala Leu Met Asp Thr Asp Gly Ser Gly Lys Leu Asn 
        35                  40                  45              


Leu Gln Glu Phe His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys 
    50                  55                  60                  


Ile Phe Lys His Tyr Asp Thr Asp Gln Ser Gly Thr Ile Asn Ser Tyr 
65                  70                  75                  80  


Glu Met Arg Asn Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln 
                85                  90                  95      


Leu Tyr Asp Ile Ile Thr Met Arg Tyr Ala Asp Lys His Met Asn Ile 
            100                 105                 110         


Asp Phe Asp Ser Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe 
        115                 120                 125             


Arg Ala Phe His Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu 
    130                 135                 140                 


Asn Val Leu Glu Trp Leu Gln Leu Thr Met Tyr Ala 
145                 150                 155     


<210>  1345
<211>  3901
<212>  DNA
<213>  Homosapiens

<400>  1345
ctattccagt gtttcagcga ggtggaagtg tgataccaat aaagacaact gtaggaaaat     60

ccacaggctg gatgactgaa tcctcctatg gactccgggt tgctctaagc actaagggtt    120

cttcagtggg tgagttatat cttgatgatg gccattcatt ccaatacctc caccagaagc    180

aatttttgca caggaagttt tcattctgtt ccagtgttct gatcaatagt tttgctgacc    240

agaggggtca ttatcccagc aagtgtgtgg tggagaagat cttggtctta ggcttcagga    300

aggagccatc ttctgtgact acccactcat ctgatggtaa agatcagcct gtggctttta    360

cgtattgtgc caaaacatcc atcctgagcc tggagaagct ctcactcaac attgccactg    420

actgggaggg ttcctaaaaa agctctaaaa tgaatgcata gtgtgtcttt ccttcaagat    480

gtaaatgtca aggaatgagt tggcaaatca gtttaaaaac acaaactacc caacagaaaa    540

atgaaatttg cgagaatccc cgatttatca ttgatggagc caacagaact gacatctgtc    600

aaggagagct aggggactgc tggtttctcg cagccattgc ctgcctgacc ctgaaccagc    660

accttctttt ccgagtcata ccccatgatc aaagtttcat cgaaaactac gcagggatct    720

tccacttcca gttctggcgc tatggagagt gggtggacgt ggttatagat gactgcctgc    780

caacgtacaa caatcaactg gttttcacca agtccaacca ccgcaatgag ttctggagtg    840

ctctgctgga gaaggcttat gctaagctcc atggttccta cgaagctctg aaaggtggga    900

acaccacaga ggccatggag gacttcacag gaggggtggc agagtttttt gagatcaggg    960

atgctcctag tgacatgtac aagatcatga agaaagccat cgagagaggc tccctcatgg   1020

gctgctccat tgatgatggc acgaacatga cctatggaac ctctccttct ggtctgaaca   1080

tgggggagtt gattgcacgg atggtaagga atatggataa ctcactgctc caggactcag   1140

acctcgaccc cagaggctca gatgaaagac cgacccggac aatcattccg gttcagtatg   1200

agacaagaat ggcctgcggg ctggtcagag gtcacgccta ctctgtcacg gggctggatg   1260

aggtcccgtt caaaggtgag aaagtgaagc tggtgcggct gcggaatccg tggggccagg   1320

tggagtggaa cggttcttgg agtgatagat ggaaggactg gagctttgtg gacaaagatg   1380

agaaggcccg tctgcagcac caggtcactg aggatggaga gttctggatg tcctatgagg   1440

atttcatcta ccatttcaca aagttggaga tctgcaacct cacggccgat gctctgcagt   1500

ctgacaagct tcagacctgg acagtgtctg tgaacgaggg ccgctgggta cggggttgct   1560

ctgccggagg ctgccgcaac ttcccagata ctttctggac caaccctcag taccgtctga   1620

agctcctgga ggaggacgat gaccctgatg actcggaggt gatttgcagc ttcctggtgg   1680

ccctgatgca gaagaaccgg cggaaggacc ggaagctagg ggccagtctc ttcaccattg   1740

gcttcgccat ctacgaggtt cccaaagagg tatagcagca gcagcggcca gcagttgtgt   1800

gcagcactac ccagggggcc ccgagtctgt ctgtggctcg tcgagaagct tcctggtggg   1860

gtttgtgggc aggactgtga taggagaggg ccttgcctgt gttatttcca ctgcagagca   1920

ggtgcctcag ggcattgcat gacccatgac taccaccccc aggatgtgca ctttctccct   1980

cgcaccagac actgcacgtc acacacatgc ctttgcacac tcaccctcct ccacgcttac   2040

agccacacac acagtcacac agacgcgttc tgagggtggc tgcccgcttg ggatggagga   2100

atcacttccc tcagaaccca gccaagtcct ctaggcctcc ttgggggtcc ttccagcctg   2160

aggggcttcg gagctgagga gcagctgttc tggtaagtgt ccctgagtgt ggggatgaca   2220

catttgccat tcactctgaa tcacaacaga aaaggaagag gaagtgaggt agggaggcta   2280

tttaagcctt gggagtcgga agtagggagg ttgaaactgt gacatgggtg accagggagt   2340

tgggaaggga cccttggagg tggctgtggc aggacaggac gttcctcccg aggggctcat   2400

gtgccctggg ctctccccat ctctcagatg cacgggaaca agcagcacct gcagaaggac   2460

ttcttcctgt acaacgcctc caaggccagg agcaaaacct acatcaacat gcgggaggtg   2520

tcccagcgct tccgcctgcc tcccagcgag tacgtcatcg tgccctccac ctacgagccc   2580

caccaggagg gggaattcat cctccgggtc ttctctgaaa agaggaacct ctctgaggaa   2640

gttgaaaata ccatctccgt ggatcggcca gtgcccatca tcttcgtttc ggacagagca   2700

aacagcaaca aggagctggg tgtggaccag gagtcagagg agggcaaagg caaaacaagc   2760

cctgataagc aaaagcagtc cccacagcca cagcctggca gctctgatca ggaaagtgag   2820

gaacagcaac aattccggaa cattttcaag cagatagcag gagatgacat ggagatctgt   2880

gcagatgagc tcaagaaggt ccttaacaca gtcgtgaaca aacacaagga cctgaagaca   2940

cacgggttca cactggagtc ctgccgtagc atgattgcgc tcatggatac agatggctct   3000

ggaaagctca acctgcagga gttccaccac ctctggaaca agattaaggc ctggcagaaa   3060

attttcaaac actatgacac agaccagtcc ggcaccatca acagctacga gatgcgaaat   3120

gcagtcaacg acgcaggatt ccacctcaac aaccagctct atgacatcat taccatgcgg   3180

tacgcagaca aacacatgaa catcgacttt gacagtttca tctgctgctt cgttaggctg   3240

gagggcatgt tcagagcttt tcatgcattt gacaaggatg gagatggtat catcaagctc   3300

aacgttctgg agtggctgca gctcaccatg tatgcctgaa ccaggctggc ctcatccaaa   3360

gccatgcagg atcactcagg atttcagttt caccctctat ttccaaagcc atttacctca   3420

aaggacccag cagctacacc cctacaggct tccaggcacc tcatcagtca tgttcctcct   3480

ccattttacc ccctacccat ccttgatcgg tcatgcctag cctgaccctt tagtaaagca   3540

atgaggtagg aagaacaaac ccttgtccct ttgccatgtg gaggaaagtg cctgcctctg   3600

gtccgagccg cctcggttct gaagcgagtg ctcctgctta ccttgctcta ggctgtctgc   3660

agaagcacct gccggtggca ctcagcacct ccttgtgcta gagccctcca tcaccttcac   3720

gctgtcccac catgggccag gaaccaaacc agcactgggt tctactgctg tggggtaaac   3780

taactcagtg gaatagggct ggttactttg ggctgtccaa ctcataagtt tggctgcatt   3840

ttgaaaaaag ctgatctaaa taaaggcatg tgtatggctg gtcaaaaaaa aaaaaaaaaa   3900

a                                                                   3901


<210>  1346
<211>  426
<212>  PRT
<213>  Homosapiens

<400>  1346

Met Ser Trp Gln Ile Ser Leu Lys Thr Gln Thr Thr Gln Gln Lys Asn 
1               5                   10                  15      


Glu Ile Cys Glu Asn Pro Arg Phe Ile Ile Asp Gly Ala Asn Arg Thr 
            20                  25                  30          


Asp Ile Cys Gln Gly Glu Leu Gly Asp Cys Trp Phe Leu Ala Ala Ile 
        35                  40                  45              


Ala Cys Leu Thr Leu Asn Gln His Leu Leu Phe Arg Val Ile Pro His 
    50                  55                  60                  


Asp Gln Ser Phe Ile Glu Asn Tyr Ala Gly Ile Phe His Phe Gln Phe 
65                  70                  75                  80  


Trp Arg Tyr Gly Glu Trp Val Asp Val Val Ile Asp Asp Cys Leu Pro 
                85                  90                  95      


Thr Tyr Asn Asn Gln Leu Val Phe Thr Lys Ser Asn His Arg Asn Glu 
            100                 105                 110         


Phe Trp Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu His Gly Ser 
        115                 120                 125             


Tyr Glu Ala Leu Lys Gly Gly Asn Thr Thr Glu Ala Met Glu Asp Phe 
    130                 135                 140                 


Thr Gly Gly Val Ala Glu Phe Phe Glu Ile Arg Asp Ala Pro Ser Asp 
145                 150                 155                 160 


Met Tyr Lys Ile Met Lys Lys Ala Ile Glu Arg Gly Ser Leu Met Gly 
                165                 170                 175     


Cys Ser Ile Asp Asp Gly Thr Asn Met Thr Tyr Gly Thr Ser Pro Ser 
            180                 185                 190         


Gly Leu Asn Met Gly Glu Leu Ile Ala Arg Met Val Arg Asn Met Asp 
        195                 200                 205             


Asn Ser Leu Leu Gln Asp Ser Asp Leu Asp Pro Arg Gly Ser Asp Glu 
    210                 215                 220                 


Arg Pro Thr Arg Thr Ile Ile Pro Val Gln Tyr Glu Thr Arg Met Ala 
225                 230                 235                 240 


Cys Gly Leu Val Arg Gly His Ala Tyr Ser Val Thr Gly Leu Asp Glu 
                245                 250                 255     


Val Pro Phe Lys Gly Glu Lys Val Lys Leu Val Arg Leu Arg Asn Pro 
            260                 265                 270         


Trp Gly Gln Val Glu Trp Asn Gly Ser Trp Ser Asp Arg Trp Lys Asp 
        275                 280                 285             


Trp Ser Phe Val Asp Lys Asp Glu Lys Ala Arg Leu Gln His Gln Val 
    290                 295                 300                 


Thr Glu Asp Gly Glu Phe Trp Met Ser Tyr Glu Asp Phe Ile Tyr His 
305                 310                 315                 320 


Phe Thr Lys Leu Glu Ile Cys Asn Leu Thr Ala Asp Ala Leu Gln Ser 
                325                 330                 335     


Asp Lys Leu Gln Thr Trp Thr Val Ser Val Asn Glu Gly Arg Trp Val 
            340                 345                 350         


Arg Gly Cys Ser Ala Gly Gly Cys Arg Asn Phe Pro Asp Thr Phe Trp 
        355                 360                 365             


Thr Asn Pro Gln Tyr Arg Leu Lys Leu Leu Glu Glu Asp Asp Asp Pro 
    370                 375                 380                 


Asp Asp Ser Glu Val Ile Cys Ser Phe Leu Val Ala Leu Met Gln Lys 
385                 390                 395                 400 


Asn Arg Arg Lys Asp Arg Lys Leu Gly Ala Ser Leu Phe Thr Ile Gly 
                405                 410                 415     


Phe Ala Ile Tyr Glu Val Pro Lys Glu Val 
            420                 425     


<210>  1347
<211>  3243
<212>  DNA
<213>  Homosapiens

<400>  1347
ctattccagt gtttcagcga ggtggaagtg tgataccaat aaagacaact gtaggaaaat     60

ccacaggctg gatgactgaa tcctcctatg gactccgggt tgctctaagc actaagggtt    120

cttcagtggg tgagttatat cttgatgatg gccattcatt ccaatacctc caccagaagc    180

aatttttgca caggaagttt tcattctgtt ccagtgttct gatcaatagt tttgctgacc    240

agaggggtca ttatcccagc aagtgtgtgg tggagaagat cttggtctta ggcttcagga    300

aggagccatc ttctgtgact acccactcat ctgatggtaa agatcagcct gtggctttta    360

cgtattgtgc caaaacatcc atcctgagcc tggagaagct ctcactcaac attgccactg    420

actgggaggg ttcctaaaaa agctctaaaa tgaatgcata gtgtgtcttt ccttcaagat    480

gtaaatgtca aggaatgagt tggcaaatca gtttaaaaac acaaactacc caacagaaaa    540

atgaaatttg cgagaatccc cgatttatca ttgatggagc caacagaact gacatctgtc    600

aaggagagct aggggactgc tggtttctcg cagccattgc ctgcctgacc ctgaaccagc    660

accttctttt ccgagtcata ccccatgatc aaagtttcat cgaaaactac gcagggatct    720

tccacttcca gttctggcgc tatggagagt gggtggacgt ggttatagat gactgcctgc    780

caacgtacaa caatcaactg gttttcacca agtccaacca ccgcaatgag ttctggagtg    840

ctctgctgga gaaggcttat gctaagctcc atggttccta cgaagctctg aaaggtggga    900

acaccacaga ggccatggag gacttcacag gaggggtggc agagtttttt gagatcaggg    960

atgctcctag tgacatgtac aagatcatga agaaagccat cgagagaggc tccctcatgg   1020

gctgctccat tgatgatggc acgaacatga cctatggaac ctctccttct ggtctgaaca   1080

tgggggagtt gattgcacgg atggtaagga atatggataa ctcactgctc caggactcag   1140

acctcgaccc cagaggctca gatgaaagac cgacccggac aatcattccg gttcagtatg   1200

agacaagaat ggcctgcggg ctggtcagag gtcacgccta ctctgtcacg gggctggatg   1260

aggtcccgtt caaaggtgag aaagtgaagc tggtgcggct gcggaatccg tggggccagg   1320

tggagtggaa cggttcttgg agtgatagat ggaaggactg gagctttgtg gacaaagatg   1380

agaaggcccg tctgcagcac caggtcactg aggatggaga gttctggatg tcctatgagg   1440

atttcatcta ccatttcaca aagttggaga tctgcaacct cacggccgat gctctgcagt   1500

ctgacaagct tcagacctgg acagtgtctg tgaacgaggg ccgctgggta cggggttgct   1560

ctgccggagg ctgccgcaac ttcccagata ctttctggac caaccctcag taccgtctga   1620

agctcctgga ggaggacgat gaccctgatg actcggaggt gatttgcagc ttcctggtgg   1680

ccctgatgca gaagaaccgg cggaaggacc ggaagctagg ggccagtctc ttcaccattg   1740

gcttcgccat ctacgaggtt cccaaagaga tgcacgggaa caagcagcac ctgcagaagg   1800

acttcttcct gtacaacgcc tccaaggcca ggagcaaaac ctacatcaac atgcgggagg   1860

tgtcccagcg cttccgcctg cctcccagcg agtacgtcat cgtgccctcc acctacgagc   1920

cccaccagga gggggaattc atcctccggg tcttctctga aaagaggaac ctctctgagg   1980

aagttgaaaa taccatctcc gtggatcggc cagtgcccat catcttcgtt tcggacagag   2040

caaacagcaa caaggagctg ggtgtggacc aggagtcaga ggagggcaaa ggcaaaacaa   2100

gccctgataa gcaaaagcag tccccacagc cacagcctgg cagctctgat caggaaagtg   2160

aggaacagca acaattccgg aacattttca agcagatagc aggagatgac atggagatct   2220

gtgcagatga gctcaagaag gtccttaaca cagtcgtgaa caaacacaag gacctgaaga   2280

cacacgggtt cacactggag tcctgccgta gcatgattgc gctcatggat acagatggct   2340

ctggaaagct caacctgcag gagttccacc acctctggaa caagattaag gcctggcaga   2400

aaattttcaa acactatgac acagaccagt ccggcaccat caacagctac gagatgcgaa   2460

atgcagtcaa cgacgcagga ttccacctca acaaccagct ctatgacatc attaccatgc   2520

ggtacgcaga caaacacatg aacatcgact ttgacagttt catctgctgc ttcgttaggc   2580

tggagggcat gttcagagct tttcatgcat ttgacaagga tggagatggt atcatcaagc   2640

tcaacgttct ggagtggctg cagctcacca tgtatgcctg aaccaggctg gcctcatcca   2700

aagccatgca ggatcactca ggatttcagt ttcaccctct atttccaaag ccatttacct   2760

caaaggaccc agcagctaca cccctacagg cttccaggca cctcatcagt catgttcctc   2820

ctccatttta ccccctaccc atccttgatc ggtcatgcct agcctgaccc tttagtaaag   2880

caatgaggta ggaagaacaa acccttgtcc ctttgccatg tggaggaaag tgcctgcctc   2940

tggtccgagc cgcctcggtt ctgaagcgag tgctcctgct taccttgctc taggctgtct   3000

gcagaagcac ctgccggtgg cactcagcac ctccttgtgc tagagccctc catcaccttc   3060

acgctgtccc accatgggcc aggaaccaaa ccagcactgg gttctactgc tgtggggtaa   3120

actaactcag tggaataggg ctggttactt tgggctgtcc aactcataag tttggctgca   3180

ttttgaaaaa agctgatcta aataaaggca tgtgtatggc tggtcaaaaa aaaaaaaaaa   3240

aaa                                                                 3243


<210>  1348
<211>  728
<212>  PRT
<213>  Homosapiens

<400>  1348

Met Ser Trp Gln Ile Ser Leu Lys Thr Gln Thr Thr Gln Gln Lys Asn 
1               5                   10                  15      


Glu Ile Cys Glu Asn Pro Arg Phe Ile Ile Asp Gly Ala Asn Arg Thr 
            20                  25                  30          


Asp Ile Cys Gln Gly Glu Leu Gly Asp Cys Trp Phe Leu Ala Ala Ile 
        35                  40                  45              


Ala Cys Leu Thr Leu Asn Gln His Leu Leu Phe Arg Val Ile Pro His 
    50                  55                  60                  


Asp Gln Ser Phe Ile Glu Asn Tyr Ala Gly Ile Phe His Phe Gln Phe 
65                  70                  75                  80  


Trp Arg Tyr Gly Glu Trp Val Asp Val Val Ile Asp Asp Cys Leu Pro 
                85                  90                  95      


Thr Tyr Asn Asn Gln Leu Val Phe Thr Lys Ser Asn His Arg Asn Glu 
            100                 105                 110         


Phe Trp Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu His Gly Ser 
        115                 120                 125             


Tyr Glu Ala Leu Lys Gly Gly Asn Thr Thr Glu Ala Met Glu Asp Phe 
    130                 135                 140                 


Thr Gly Gly Val Ala Glu Phe Phe Glu Ile Arg Asp Ala Pro Ser Asp 
145                 150                 155                 160 


Met Tyr Lys Ile Met Lys Lys Ala Ile Glu Arg Gly Ser Leu Met Gly 
                165                 170                 175     


Cys Ser Ile Asp Asp Gly Thr Asn Met Thr Tyr Gly Thr Ser Pro Ser 
            180                 185                 190         


Gly Leu Asn Met Gly Glu Leu Ile Ala Arg Met Val Arg Asn Met Asp 
        195                 200                 205             


Asn Ser Leu Leu Gln Asp Ser Asp Leu Asp Pro Arg Gly Ser Asp Glu 
    210                 215                 220                 


Arg Pro Thr Arg Thr Ile Ile Pro Val Gln Tyr Glu Thr Arg Met Ala 
225                 230                 235                 240 


Cys Gly Leu Val Arg Gly His Ala Tyr Ser Val Thr Gly Leu Asp Glu 
                245                 250                 255     


Val Pro Phe Lys Gly Glu Lys Val Lys Leu Val Arg Leu Arg Asn Pro 
            260                 265                 270         


Trp Gly Gln Val Glu Trp Asn Gly Ser Trp Ser Asp Arg Trp Lys Asp 
        275                 280                 285             


Trp Ser Phe Val Asp Lys Asp Glu Lys Ala Arg Leu Gln His Gln Val 
    290                 295                 300                 


Thr Glu Asp Gly Glu Phe Trp Met Ser Tyr Glu Asp Phe Ile Tyr His 
305                 310                 315                 320 


Phe Thr Lys Leu Glu Ile Cys Asn Leu Thr Ala Asp Ala Leu Gln Ser 
                325                 330                 335     


Asp Lys Leu Gln Thr Trp Thr Val Ser Val Asn Glu Gly Arg Trp Val 
            340                 345                 350         


Arg Gly Cys Ser Ala Gly Gly Cys Arg Asn Phe Pro Asp Thr Phe Trp 
        355                 360                 365             


Thr Asn Pro Gln Tyr Arg Leu Lys Leu Leu Glu Glu Asp Asp Asp Pro 
    370                 375                 380                 


Asp Asp Ser Glu Val Ile Cys Ser Phe Leu Val Ala Leu Met Gln Lys 
385                 390                 395                 400 


Asn Arg Arg Lys Asp Arg Lys Leu Gly Ala Ser Leu Phe Thr Ile Gly 
                405                 410                 415     


Phe Ala Ile Tyr Glu Val Pro Lys Glu Met His Gly Asn Lys Gln His 
            420                 425                 430         


Leu Gln Lys Asp Phe Phe Leu Tyr Asn Ala Ser Lys Ala Arg Ser Lys 
        435                 440                 445             


Thr Tyr Ile Asn Met Arg Glu Val Ser Gln Arg Phe Arg Leu Pro Pro 
    450                 455                 460                 


Ser Glu Tyr Val Ile Val Pro Ser Thr Tyr Glu Pro His Gln Glu Gly 
465                 470                 475                 480 


Glu Phe Ile Leu Arg Val Phe Ser Glu Lys Arg Asn Leu Ser Glu Glu 
                485                 490                 495     


Val Glu Asn Thr Ile Ser Val Asp Arg Pro Val Pro Ile Ile Phe Val 
            500                 505                 510         


Ser Asp Arg Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser 
        515                 520                 525             


Glu Glu Gly Lys Gly Lys Thr Ser Pro Asp Lys Gln Lys Gln Ser Pro 
    530                 535                 540                 


Gln Pro Gln Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln 
545                 550                 555                 560 


Phe Arg Asn Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys 
                565                 570                 575     


Ala Asp Glu Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His Lys 
            580                 585                 590         


Asp Leu Lys Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile 
        595                 600                 605             


Ala Leu Met Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe 
    610                 615                 620                 


His His Leu Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His 
625                 630                 635                 640 


Tyr Asp Thr Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn 
                645                 650                 655     


Ala Val Asn Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile 
            660                 665                 670         


Ile Thr Met Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser 
        675                 680                 685             


Phe Ile Cys Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His 
    690                 695                 700                 


Ala Phe Asp Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu 
705                 710                 715                 720 


Trp Leu Gln Leu Thr Met Tyr Ala 
                725             


<210>  1349
<211>  3521
<212>  DNA
<213>  Homosapiens

<400>  1349
ctattccagt gtttcagcga ggtggaagtg tgataccaat aaagacaact gtaggaaaat     60

ccacaggctg gatgactgaa tcctcctatg gactccgggt tgctctaagc actaagggtt    120

cttcagtggg tgagttatat cttgatgatg gccattcatt ccaatacctc caccagaagc    180

aatttttgca caggaagttt tcattctgtt ccagtgttct gatcaatagt tttgctgacc    240

agaggggtca ttatcccagc aagtgtgtgg tggagaagat cttggtctta ggcttcagga    300

aggagccatc ttctgtgact acccactcat ctgatggtaa agatcagcct gtggctttta    360

cgtattgtgc caaaacatcc atcctgagcc tggagaagct ctcactcaac attgccactg    420

actgggaggg ttcctaaaaa agctctaaaa tgaatgcata gtgtgtcttt ccttcaagat    480

gtaaatgtca aggaatgagt tggcaaatca gtttaaaaac acaaactacc caacagaaaa    540

atgaaatttg cgagaatccc cgatttatca ttgatggagc caacagaact gacatctgtc    600

aaggagagct agacgggttc cagggcagct gcctacctgg ccttccttcc aatacaaatc    660

atcttggtgg atggttctct gaggctcagt cttcgctgaa gtcagaagag gaattggact    720

cacattgcaa aggcacaggg cagggcagat ttcctacagg tgttaggaag aacaacccag    780

ttatgatcac ctactgctct gtctccattg aggcctaaaa aggaagtgag tttatactgc    840

agttggagga actgcctgca gccttgagga aaatgtctag tcacaaggga gggactgctg    900

gtttctcgca gccattgcct gcctgaccct gaaccagcac cttcttttcc gagtcatacc    960

ccatgatcaa agtttcatcg aaaactacgc agggatcttc cacttccagt tctggcgcta   1020

tggagagtgg gtggacgtgg ttatagatga ctgcctgcca acgtacaaca atcaactggt   1080

tttcaccaag tccaaccacc gcaatgagtt ctggagtgct ctgctggaga aggcttatgc   1140

taagctccat ggttcctacg aagctctgaa aggtgggaac accacagagg ccatggagga   1200

cttcacagga ggggtggcag agttttttga gatcagggat gctcctagtg acatgtacaa   1260

gatcatgaag aaagccatcg agagaggctc cctcatgggc tgctccattg atgatggcac   1320

gaacatgacc tatggaacct ctccttctgg tctgaacatg ggggagttga ttgcacggat   1380

ggtaaggaat atggataact cactgctcca ggactcagac ctcgacccca gaggctcaga   1440

tgaaagaccg acccggacaa tcattccggt tcagtatgag acaagaatgg cctgcgggct   1500

ggtcagaggt cacgcctact ctgtcacggg gctggatgag gtcccgttca aaggtgagaa   1560

agtgaagctg gtgcggctgc ggaatccgtg gggccaggtg gagtggaacg gttcttggag   1620

tgatagatgg aaggactgga gctttgtgga caaagatgag aaggcccgtc tgcagcacca   1680

ggtcactgag gatggagagt tctggatgtc ctatgaggat ttcatctacc atttcacaaa   1740

gttggagatc tgcaacctca cggccgatgc tctgcagtct gacaagcttc agacctggac   1800

agtgtctgtg aacgagggcc gctgggtacg gggttgctct gccggaggct gccgcaactt   1860

cccagatact ttctggacca accctcagta ccgtctgaag ctcctggagg aggacgatga   1920

ccctgatgac tcggaggtga tttgcagctt cctggtggcc ctgatgcaga agaaccggcg   1980

gaaggaccgg aagctagggg ccagtctctt caccattggc ttcgccatct acgaggttcc   2040

caaagagatg cacgggaaca agcagcacct gcagaaggac ttcttcctgt acaacgcctc   2100

caaggccagg agcaaaacct acatcaacat gcgggaggtg tcccagcgct tccgcctgcc   2160

tcccagcgag tacgtcatcg tgccctccac ctacgagccc caccaggagg gggaattcat   2220

cctccgggtc ttctctgaaa agaggaacct ctctgaggaa gttgaaaata ccatctccgt   2280

ggatcggcca gtgcccatca tcttcgtttc ggacagagca aacagcaaca aggagctggg   2340

tgtggaccag gagtcagagg agggcaaagg caaaacaagc cctgataagc aaaagcagtc   2400

cccacagcca cagcctggca gctctgatca ggaaagtgag gaacagcaac aattccggaa   2460

cattttcaag cagatagcag gagatgacat ggagatctgt gcagatgagc tcaagaaggt   2520

ccttaacaca gtcgtgaaca aacacaagga cctgaagaca cacgggttca cactggagtc   2580

ctgccgtagc atgattgcgc tcatggatac agatggctct ggaaagctca acctgcagga   2640

gttccaccac ctctggaaca agattaaggc ctggcagaaa attttcaaac actatgacac   2700

agaccagtcc ggcaccatca acagctacga gatgcgaaat gcagtcaacg acgcaggatt   2760

ccacctcaac aaccagctct atgacatcat taccatgcgg tacgcagaca aacacatgaa   2820

catcgacttt gacagtttca tctgctgctt cgttaggctg gagggcatgt tcagagcttt   2880

tcatgcattt gacaaggatg gagatggtat catcaagctc aacgttctgg agtggctgca   2940

gctcaccatg tatgcctgaa ccaggctggc ctcatccaaa gccatgcagg atcactcagg   3000

atttcagttt caccctctat ttccaaagcc atttacctca aaggacccag cagctacacc   3060

cctacaggct tccaggcacc tcatcagtca tgttcctcct ccattttacc ccctacccat   3120

ccttgatcgg tcatgcctag cctgaccctt tagtaaagca atgaggtagg aagaacaaac   3180

ccttgtccct ttgccatgtg gaggaaagtg cctgcctctg gtccgagccg cctcggttct   3240

gaagcgagtg ctcctgctta ccttgctcta ggctgtctgc agaagcacct gccggtggca   3300

ctcagcacct ccttgtgcta gagccctcca tcaccttcac gctgtcccac catgggccag   3360

gaaccaaacc agcactgggt tctactgctg tggggtaaac taactcagtg gaatagggct   3420

ggttactttg ggctgtccaa ctcataagtt tggctgcatt ttgaaaaaag ctgatctaaa   3480

taaaggcatg tgtatggctg gtcaaaaaaa aaaaaaaaaa a                       3521


<210>  1350
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  1350

Met Ser Trp Gln Ile Ser Leu Lys Thr Gln Thr Thr Gln Gln Lys Asn 
1               5                   10                  15      


Glu Ile Cys Glu Asn Pro Arg Phe Ile Ile Asp Gly Ala Asn Arg Thr 
            20                  25                  30          


Asp Ile Cys Gln Gly Glu Leu Asp Gly Phe Gln Gly Ser Cys Leu Pro 
        35                  40                  45              


Gly Leu Pro Ser Asn Thr Asn His Leu Gly Gly Trp Phe Ser Glu Ala 
    50                  55                  60                  


Gln Ser Ser Leu Lys Ser Glu Glu Glu Leu Asp Ser His Cys Lys Gly 
65                  70                  75                  80  


Thr Gly Gln Gly Arg Phe Pro Thr Gly Val Arg Lys Asn Asn Pro Val 
                85                  90                  95      


Met Ile Thr Tyr Cys Ser Val Ser Ile Glu Ala 
            100                 105         


<210>  1351
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1351
acgcggggga gtgcagctgg caccatgggt gtgctccaga gcaacttctg cttgctctga     60

gccccctgcc ctgcctcccc tttcaccatg tttcctctga caagatttta agtacagcaa    120

ttcaagaaga tttctcctcc taaacgacat ttatctgaag tctattgcct cttgattgct    180

ggaaaagaat cttaaaatca tttcaaaagt aacttataaa caaacttatt aaaagtgatg    240

aaaggagcat tgaaattaat tagcactaat ttttcactgt gccaaagtgt gcagtgtcct    300

tcagaggaaa caataacaga tctggtgagt gtgccatgcc agtggggaga attgaatgtc    360

cctcatctcc ctctttccct agggacatta gtcatgagtg ccgagtgtgc ggggtcacag    420

aagtgggtct ttctgcatat gcaaagcaca tttctggcca gttgcacaaa gataacgttg    480

atgcccagga aagagaagat gatggaaaag gagaggaaga ggaagaagat tattttgaca    540

aggaactcat tcagttaata aaacaaagga aagaacaaag tcgacaagat gaaccttcca    600

atagcaacca agaaataaac tctgatgaca gacgacccca atggagacga gaagaccgaa    660

ttccttacca agacagagag agttacagtc agcctgcatg gcatcatcgt ggacctccac    720

agcgggattg gaaatgggaa aaagatggct ttaataatac taggaaaaac agctttccac    780

attctttgag gaatggtggt ggaccaagag gacgttccgg gtggcataag ggtgttgcag    840

gaggctcctc gacttggttt cacaaccata gtaattctgg aggtggttgg ctttcaaata    900

gtggagcagt agattggaat cataatggta caggaaggaa ttccagttgg ctttctgaag    960

gaacaggtgg cttttccagt tggcatatga acaacagtaa cggaaactgg aaatccagtg   1020

tacgtagtac aaataattgg aattacagtg gccctggaga caaatttcaa ccaggcagaa   1080

acagaaattc taactgtcaa atggaagaca tgactatgct atggaacaag aaatctaata   1140

agtcaaacaa atacagtcac gacagatata attggcagcg gcaagaaaat gacaaacttg   1200

gtacagttgc cacatataga ggtccttctg aaggatttac aagtgataaa tttccttcag   1260

aaggcttact cgacttcaat tttgagcagc tggaaagcca aaccactaaa caagcagaca   1320

ctgctacttc caaagttagt ggaaagaatg gcagtgcggc aagggaaaag cctcgtcgct   1380

ggacgcctta cccttctcag aagactctgg atttacagtc gggattgaaa gacatcactg   1440

gtaacaagtc agaaatgata gagaaacctc tctttgattt tagcttgata actacaggaa   1500

tacaggagcc ccaaactgat gaaacacgta attccccaac acagaaaaca caaaaagaaa   1560

tacatactgg atctcttaat cacaaggcct cttctgattc cgctgcttcc ttcgaggtgg   1620

tgagacagtg ccccactgca gaaaaacctg aacaagagca tacaccaaat aaaatgccat   1680

cattgaaatc cccactcctt ccatgtccag ccactaaatc attgtctcaa aagcaagatc   1740

caaagaatat ctcaaaaaac accaaaacaa attttttttc ccctggagaa cactcaaatc   1800

cctcgaacaa gcccactgtg gaagataacc atggtcctta catatccaaa ctgcgtagtt   1860

catgtcctca tgttttaaaa gggaataaaa gtacatttgg ctctcaaaag caatctggtg   1920

ataatttaaa tgatacttta cgaaaggcca aagaggtgct acagtgtcat gagtcattgc   1980

aaaatccact tcttagcact tctaaaagta ccaggaacta tgcaaaagca agtagaaatg   2040

tagaagaatc tgaaaaaggg tctttgaaaa ttgagtttca agtgcacgca ctagaagatg   2100

aaagtgatgg agagacatct gacacggaaa agcatggaac aaaaattgga accctaggtt   2160

ctgcaactac agaattgtta tctggcagca ctcgaactgc tgatgagaaa gaggaggatg   2220

accgcatcct gaagacttct agagagctat ccacttcccc atgtaatccc atagttcgcc   2280

agaaagaatc tgaattacaa atgacatctg cagccagtcc acaccctggc ttattgctag   2340

acttgaaaac ctctctagaa gatgcacagg ttgatgactc tattaaatct catgtatctt   2400

atgaaacaga aggctttgag agtgctagct tggatgcaga gcttcaaaaa agtgacatca   2460

gtcagccctc gggccctctc ctgcctgaac taagtaagct tggctttcct gcctcacttc   2520

agagggatct aacccggcac attagtttga agagcaaaac tggagtacac cttcctgagc   2580

caaacctcaa tagtgcccgc cgcattcgca atattagcgg tcaccgaaag agtgagacag   2640

agaaggagtc tgggctcaag ccaaccctac ggcagattct aaatgcatct cggagaaatg   2700

tcaactggga acaggtcatt cagcaagtaa ccaagaaaaa gcaagagctg ggcaaaggct   2760

tacccaggtt tggcatagaa atggtacccc ttgttcaaaa tgaacaagaa gccttagatt   2820

tggatgggga acctgatctg tccagtctag aaggattcca gtgggaaggt gtttccattt   2880

cctcgtcccc tggcttggca agaaagcgaa gcctttctga gagcagcgtg atcatggaca   2940

gagctccttc tgtgtatagc ttcttcagtg aggaaggtac aggcaaagaa aatgagcccc   3000

agcagatggt ttcacctagt aactcattga gggctggaca gagccagaaa gcaaccatgc   3060

acctcaaaca agaagtgaca cctcgggctg cctccctccg aacaggtgaa agggctgaaa   3120

atgttgctac ccaaaggcga catagtgcac aattatcctc tgaccatata atacctttga   3180

tgcatttggc aaaagacttg aacagccagg agaggtctat accaccgtca gagaatcaga   3240

attcccagga gagtaatgga gagggaaact gtctgtcatc aagcgcatcc tcagcccttg   3300

cgatctccag tttagcggat gcagccacag atagtagctg tacctctggt gctgaacaaa   3360

atgatggcca aagtattaga aagaaacgaa gagccactgg agatggatct tctcctgaac   3420

tcccaagtct tgagagaaaa aataaaagaa ggaaaattaa aggaaaaaaa gaacgttctc   3480

aggttgacca gctgctgaat atttctttaa gggaggaaga acttagtaag tcattgcagt   3540

gcatggataa caatcttctg caagcccgtg cagcccttca gacagcttat gtggaagttc   3600

agaggctact tatgctcaag cagcagataa ctatggagat gagtgcactg aggacccata   3660

gaatacagat tctacaggga ttacaagaaa catatgaacc ttctgagcac ccagaccagg   3720

ttccctgtag cctcacacga gaacgaagga acagtagatc tcaaacatcc attgatgccg   3780

cactgctgcc cactcccttt ttcccacttt ttctggagcc tccatcttcc catgtgtctc   3840

catcacccac cggagcctct cttcaaataa ccacgtctcc tactttccaa acccatggca   3900

gtgtccctgc tccagactca tcagttcaga ttaaacaaga gcccatgtct cctgaacaag   3960

atgagaatgt gaatgctgtg ccaccaagct ctgcctgcaa tgtgtccaag gaattactgg   4020

aagctaatag agagatcagt gacagttgtc cagtttatcc agtcatcact gctagattgt   4080

ccttaccaga gtcaacagaa agtttccatg agcctagcca agaactgaag ttttctgtgg   4140

agcaaagaaa taccagaaac agagaaaact ctccctcttc ccaatcagct ggtctttcta   4200

gcataaataa agaaggggaa gagccaacca aaggcaatag tgggtctgaa gcctgtacca   4260

gttcttttct aagattgtct tttgcttcag aaaccccttt ggagaaggaa ccccactctc   4320

cagctgacca gcctgaacaa caggcagaat ccactttgac atcagctgag actaggggaa   4380

gcaagaaaaa gaagaaactc cggaagaaga aaagtctacg ggctgcccat gttcctgaga   4440

atagtgacac tgaacaggat gttttgactg ttaaacctgt aaggaaagta aaagctggaa   4500

agttaattaa aggggggaaa gtaacaacct ccacttggga agacagcagg actggtcggg   4560

agcaggagag tgtcagagat gagccagata gtgactcgtc tctggaagtc ctagaaattc   4620

ctaatcctca gttagaagta gtagccattg attcttcaga atcaggagaa gagaaaccag   4680

acagcccatc taaaaaggat atttggaact ctacagagca aaacccacta gaaacgtctc   4740

gttctgggtg tgatgaagtt agctctacca gtgaaattgg cactcgctat aaagatggca   4800

tccctgtaag tgtggcagaa actcagactg tgatctcctc cataaaagga tcaaagaatt   4860

cttcagaaat atcttcagag ccaggagatg atgatgaacc cacagaagga agctttgagg   4920

gacaccaagc tgccgtaaat gcaattcaga tatttgggaa cttgctatat acctgttcag   4980

cagataaaac tgttcgggtt tataatctgg tgagtcggaa atgtattggt gtctttgagg   5040

gtcatacctc caaagttaac tgcctcctgg ttactcagac ctccgggaag aatgctgccc   5100

tttacaccgg gtccagtgac cataccatcc gctgctataa tgttaagagc cgagagtgtg   5160

tggagcagtt acagctggaa gaccgggtcc tctgcctcca cagtagatgg cgaatcctct   5220

atgcgggact ggcaaatggc actgtggtca ccttcaacat aaagaacaac aaacgacttg   5280

agatctttga atgccatggc cctcgggcag tcagctgtct tgctacagct caggaaggtg   5340

cccgaaaact gctggtcgtg gggtcttatg actgcacaat tagtgtacgc gatgcccgga   5400

atggactgct cctcagaact ctggagggcc atagcaaaac cattctttgc atgaaggtgg   5460

tgaatgatct cgtgttcagt ggctccagtg atcagtcagt ccatgctcac aacattcaca   5520

ctggtgagct cgtgcggatc tataaaggtc acaatcatgc agtgactgtg gtgaatatcc   5580

taggaaaagt gatggtgact gcttgcctgg ataaatttgt tcgtgtctat gaattacagt   5640

ctcatgatcg attacaagtt tatggaggac acaaagacat gattatgtgt atgaccatcc   5700

ataaaagcat gatttacact ggctgttatg atggcagtat tcaggccgtg aggcttaatc   5760

tgatgcagaa ttaccgctgt tggtggcatg gttgctctct gatatttggc gttgtagatc   5820

atttaaaaca acacttgctg accgaccaca ctaatcccaa cttccagact ctgaaatgtc   5880

gctggaagaa ctgcgatgct tttttcactg ctaggaaagg atccaaacag gatgctgcag   5940

gacatattga acgacatgct gaagatgaca gcaaaattga ttcatgaagt tttttgcctc   6000

ccacgttggg aagtcattag ttgaactatt ttcacattgg ccccccacac aggccactct   6060

cttccctttc ttggtgaagt aaggaaggag aaagtggtta ctagccaggc atacccctag   6120

cataagtctg ggcagctcta tgggatgata aattacactt ttaagttctt gctggaggtt   6180

ttaaatagat ttagacaaat gttaaggaac catacttctc tgggacagca tggcatatag   6240

tgatatatgc tatttgcgtt ctccagatgt ttattgaaga tacagatcct aattggttac   6300

ccagtttgac cctaatcata tgtatatttt attgatttca gtttgcaatt tttaatttat   6360

gttcttatga tggtttaaac ctatagtcag gcttttaagt acaagtttgt ttaagtgcca   6420

gactttgagg atcagtttta atttctccat ttgtaatagc tgggtattta aactggaagc   6480

aaatagtttt ctttcttaac aattatgtgc agtgtgtgtc actgttttct tgctttatag   6540

atagagctgg ctttaagtgc taaaggacac agtagatttt tgacaaacag tggctgctct   6600

gctgactatc ttttaggaat tcaggaagca aatcacatag tgacaagtcc ttacagacac   6660

cacttctagt aaatctctgt aaatgtggat agaaagctca gtgtgaggca gtgcgtagac   6720

ctaacgtcta cctttacatc tgctgttgaa cctgggcact acctgttaca gatcctgtca   6780

ggctgttgaa ctggaggtgt acctttatct tcctttctag tgtctgaccc tgcaagccta   6840

atgttggttt gaaccctttt ggtttgttca gttgccagcc tccatctctc ccactgtatg   6900

gccgtgccta gaccgatggc agccatcgaa tattcctctg ggctcacggg gtgttttcca   6960

cccccctgca gcaactaaga tggtggggga gagggggtta gaataaagca tctgaataca   7020

gttttcagga cctcaagcag acttcctaga gacttgtttc tgagacagtt ctttgccttc   7080

acttccctgc tagctgggaa agaagagtgg agcagagact ctgcctggcc actgagaaca   7140

gccaaattca caaaccctca gtggggcttt gtttttggat tttctccgga ctcatcagta   7200

aacctgtaga agtgtcgctt tccagccttt tgtttctgga tcctcaaaac tcagaacgtg   7260

gccgggcgtg gtggctcacg cctgtaatcc cagcactttg ggaggctgag gcaggcagat   7320

cacctgaggc taggagttgc agaccagcct ggccaacatg gcaaaacccc gtctctacta   7380

aaaatacaaa aagccgggcg tggtgggcgc ctgtaatccc agctgctcag gaggctgagg   7440

caggagaatc gcttgaaccc gggaggcaga gattgcagta agctgagatc gtgccactgc   7500

actccagcct ggtgacagag tgagactccg tctcaaaaaa aaaaaaaaaa actcagcttc   7560

ttcagagaga taaaattggg ggaggagccc agggccacat accaagcttt gggacatggt   7620

gcctcatgct ctctgggatt gcagaccatc caggtctgtc ttcgcccctg ttagtgcaca   7680

tatatccact cacatgtctt ccctcaggct atcgggcagg gggacttcac cagggggttt   7740

atggataggc ttcaagaggg tctgtgagcc cccagaaatt gtgtgtgaga ctgagtatgt   7800

gttctttttt ccaggaaagg ctccagtggt tcttacttga tccaaaaaat gtcaagaatt   7860

aatctaggag gccgggcctg gtggctcaca cctgtaatcc cagctctttg ggaggccgag   7920

gcgggtggat cactcaaggt caggcatttg agaccagcct ggccaacata gtgaaacccc   7980

gtctctatta aaaatacaaa aattagctgg gtgtggtggt atgtgcctgt agtctcagct   8040

actcaggagg ctgagacagg agaatcactt gaaccctgga ggtagaagtt gcagtgagcc   8100

aagatcatac tactgcactc cagcctgggc gacaagagtg aaactccacc tcaaaaaaaa   8160

aaaaaaaaga gttaatctag gagataatga at                                 8192


<210>  1352
<211>  1883
<212>  PRT
<213>  Homosapiens

<400>  1352

Met Pro Val Gly Arg Ile Glu Cys Pro Ser Ser Pro Ser Phe Pro Arg 
1               5                   10                  15      


Asp Ile Ser His Glu Cys Arg Val Cys Gly Val Thr Glu Val Gly Leu 
            20                  25                  30          


Ser Ala Tyr Ala Lys His Ile Ser Gly Gln Leu His Lys Asp Asn Val 
        35                  40                  45              


Asp Ala Gln Glu Arg Glu Asp Asp Gly Lys Gly Glu Glu Glu Glu Glu 
    50                  55                  60                  


Asp Tyr Phe Asp Lys Glu Leu Ile Gln Leu Ile Lys Gln Arg Lys Glu 
65                  70                  75                  80  


Gln Ser Arg Gln Asp Glu Pro Ser Asn Ser Asn Gln Glu Ile Asn Ser 
                85                  90                  95      


Asp Asp Arg Arg Pro Gln Trp Arg Arg Glu Asp Arg Ile Pro Tyr Gln 
            100                 105                 110         


Asp Arg Glu Ser Tyr Ser Gln Pro Ala Trp His His Arg Gly Pro Pro 
        115                 120                 125             


Gln Arg Asp Trp Lys Trp Glu Lys Asp Gly Phe Asn Asn Thr Arg Lys 
    130                 135                 140                 


Asn Ser Phe Pro His Ser Leu Arg Asn Gly Gly Gly Pro Arg Gly Arg 
145                 150                 155                 160 


Ser Gly Trp His Lys Gly Val Ala Gly Gly Ser Ser Thr Trp Phe His 
                165                 170                 175     


Asn His Ser Asn Ser Gly Gly Gly Trp Leu Ser Asn Ser Gly Ala Val 
            180                 185                 190         


Asp Trp Asn His Asn Gly Thr Gly Arg Asn Ser Ser Trp Leu Ser Glu 
        195                 200                 205             


Gly Thr Gly Gly Phe Ser Ser Trp His Met Asn Asn Ser Asn Gly Asn 
    210                 215                 220                 


Trp Lys Ser Ser Val Arg Ser Thr Asn Asn Trp Asn Tyr Ser Gly Pro 
225                 230                 235                 240 


Gly Asp Lys Phe Gln Pro Gly Arg Asn Arg Asn Ser Asn Cys Gln Met 
                245                 250                 255     


Glu Asp Met Thr Met Leu Trp Asn Lys Lys Ser Asn Lys Ser Asn Lys 
            260                 265                 270         


Tyr Ser His Asp Arg Tyr Asn Trp Gln Arg Gln Glu Asn Asp Lys Leu 
        275                 280                 285             


Gly Thr Val Ala Thr Tyr Arg Gly Pro Ser Glu Gly Phe Thr Ser Asp 
    290                 295                 300                 


Lys Phe Pro Ser Glu Gly Leu Leu Asp Phe Asn Phe Glu Gln Leu Glu 
305                 310                 315                 320 


Ser Gln Thr Thr Lys Gln Ala Asp Thr Ala Thr Ser Lys Val Ser Gly 
                325                 330                 335     


Lys Asn Gly Ser Ala Ala Arg Glu Lys Pro Arg Arg Trp Thr Pro Tyr 
            340                 345                 350         


Pro Ser Gln Lys Thr Leu Asp Leu Gln Ser Gly Leu Lys Asp Ile Thr 
        355                 360                 365             


Gly Asn Lys Ser Glu Met Ile Glu Lys Pro Leu Phe Asp Phe Ser Leu 
    370                 375                 380                 


Ile Thr Thr Gly Ile Gln Glu Pro Gln Thr Asp Glu Thr Arg Asn Ser 
385                 390                 395                 400 


Pro Thr Gln Lys Thr Gln Lys Glu Ile His Thr Gly Ser Leu Asn His 
                405                 410                 415     


Lys Ala Ser Ser Asp Ser Ala Ala Ser Phe Glu Val Val Arg Gln Cys 
            420                 425                 430         


Pro Thr Ala Glu Lys Pro Glu Gln Glu His Thr Pro Asn Lys Met Pro 
        435                 440                 445             


Ser Leu Lys Ser Pro Leu Leu Pro Cys Pro Ala Thr Lys Ser Leu Ser 
    450                 455                 460                 


Gln Lys Gln Asp Pro Lys Asn Ile Ser Lys Asn Thr Lys Thr Asn Phe 
465                 470                 475                 480 


Phe Ser Pro Gly Glu His Ser Asn Pro Ser Asn Lys Pro Thr Val Glu 
                485                 490                 495     


Asp Asn His Gly Pro Tyr Ile Ser Lys Leu Arg Ser Ser Cys Pro His 
            500                 505                 510         


Val Leu Lys Gly Asn Lys Ser Thr Phe Gly Ser Gln Lys Gln Ser Gly 
        515                 520                 525             


Asp Asn Leu Asn Asp Thr Leu Arg Lys Ala Lys Glu Val Leu Gln Cys 
    530                 535                 540                 


His Glu Ser Leu Gln Asn Pro Leu Leu Ser Thr Ser Lys Ser Thr Arg 
545                 550                 555                 560 


Asn Tyr Ala Lys Ala Ser Arg Asn Val Glu Glu Ser Glu Lys Gly Ser 
                565                 570                 575     


Leu Lys Ile Glu Phe Gln Val His Ala Leu Glu Asp Glu Ser Asp Gly 
            580                 585                 590         


Glu Thr Ser Asp Thr Glu Lys His Gly Thr Lys Ile Gly Thr Leu Gly 
        595                 600                 605             


Ser Ala Thr Thr Glu Leu Leu Ser Gly Ser Thr Arg Thr Ala Asp Glu 
    610                 615                 620                 


Lys Glu Glu Asp Asp Arg Ile Leu Lys Thr Ser Arg Glu Leu Ser Thr 
625                 630                 635                 640 


Ser Pro Cys Asn Pro Ile Val Arg Gln Lys Glu Ser Glu Leu Gln Met 
                645                 650                 655     


Thr Ser Ala Ala Ser Pro His Pro Gly Leu Leu Leu Asp Leu Lys Thr 
            660                 665                 670         


Ser Leu Glu Asp Ala Gln Val Asp Asp Ser Ile Lys Ser His Val Ser 
        675                 680                 685             


Tyr Glu Thr Glu Gly Phe Glu Ser Ala Ser Leu Asp Ala Glu Leu Gln 
    690                 695                 700                 


Lys Ser Asp Ile Ser Gln Pro Ser Gly Pro Leu Leu Pro Glu Leu Ser 
705                 710                 715                 720 


Lys Leu Gly Phe Pro Ala Ser Leu Gln Arg Asp Leu Thr Arg His Ile 
                725                 730                 735     


Ser Leu Lys Ser Lys Thr Gly Val His Leu Pro Glu Pro Asn Leu Asn 
            740                 745                 750         


Ser Ala Arg Arg Ile Arg Asn Ile Ser Gly His Arg Lys Ser Glu Thr 
        755                 760                 765             


Glu Lys Glu Ser Gly Leu Lys Pro Thr Leu Arg Gln Ile Leu Asn Ala 
    770                 775                 780                 


Ser Arg Arg Asn Val Asn Trp Glu Gln Val Ile Gln Gln Val Thr Lys 
785                 790                 795                 800 


Lys Lys Gln Glu Leu Gly Lys Gly Leu Pro Arg Phe Gly Ile Glu Met 
                805                 810                 815     


Val Pro Leu Val Gln Asn Glu Gln Glu Ala Leu Asp Leu Asp Gly Glu 
            820                 825                 830         


Pro Asp Leu Ser Ser Leu Glu Gly Phe Gln Trp Glu Gly Val Ser Ile 
        835                 840                 845             


Ser Ser Ser Pro Gly Leu Ala Arg Lys Arg Ser Leu Ser Glu Ser Ser 
    850                 855                 860                 


Val Ile Met Asp Arg Ala Pro Ser Val Tyr Ser Phe Phe Ser Glu Glu 
865                 870                 875                 880 


Gly Thr Gly Lys Glu Asn Glu Pro Gln Gln Met Val Ser Pro Ser Asn 
                885                 890                 895     


Ser Leu Arg Ala Gly Gln Ser Gln Lys Ala Thr Met His Leu Lys Gln 
            900                 905                 910         


Glu Val Thr Pro Arg Ala Ala Ser Leu Arg Thr Gly Glu Arg Ala Glu 
        915                 920                 925             


Asn Val Ala Thr Gln Arg Arg His Ser Ala Gln Leu Ser Ser Asp His 
    930                 935                 940                 


Ile Ile Pro Leu Met His Leu Ala Lys Asp Leu Asn Ser Gln Glu Arg 
945                 950                 955                 960 


Ser Ile Pro Pro Ser Glu Asn Gln Asn Ser Gln Glu Ser Asn Gly Glu 
                965                 970                 975     


Gly Asn Cys Leu Ser Ser Ser Ala Ser Ser Ala Leu Ala Ile Ser Ser 
            980                 985                 990         


Leu Ala Asp Ala Ala Thr Asp Ser  Ser Cys Thr Ser Gly  Ala Glu Gln 
        995                 1000                 1005             


Asn Asp  Gly Gln Ser Ile Arg  Lys Lys Arg Arg Ala  Thr Gly Asp 
    1010                 1015                 1020             


Gly Ser  Ser Pro Glu Leu Pro  Ser Leu Glu Arg Lys  Asn Lys Arg 
    1025                 1030                 1035             


Arg Lys  Ile Lys Gly Lys Lys  Glu Arg Ser Gln Val  Asp Gln Leu 
    1040                 1045                 1050             


Leu Asn  Ile Ser Leu Arg Glu  Glu Glu Leu Ser Lys  Ser Leu Gln 
    1055                 1060                 1065             


Cys Met  Asp Asn Asn Leu Leu  Gln Ala Arg Ala Ala  Leu Gln Thr 
    1070                 1075                 1080             


Ala Tyr  Val Glu Val Gln Arg  Leu Leu Met Leu Lys  Gln Gln Ile 
    1085                 1090                 1095             


Thr Met  Glu Met Ser Ala Leu  Arg Thr His Arg Ile  Gln Ile Leu 
    1100                 1105                 1110             


Gln Gly  Leu Gln Glu Thr Tyr  Glu Pro Ser Glu His  Pro Asp Gln 
    1115                 1120                 1125             


Val Pro  Cys Ser Leu Thr Arg  Glu Arg Arg Asn Ser  Arg Ser Gln 
    1130                 1135                 1140             


Thr Ser  Ile Asp Ala Ala Leu  Leu Pro Thr Pro Phe  Phe Pro Leu 
    1145                 1150                 1155             


Phe Leu  Glu Pro Pro Ser Ser  His Val Ser Pro Ser  Pro Thr Gly 
    1160                 1165                 1170             


Ala Ser  Leu Gln Ile Thr Thr  Ser Pro Thr Phe Gln  Thr His Gly 
    1175                 1180                 1185             


Ser Val  Pro Ala Pro Asp Ser  Ser Val Gln Ile Lys  Gln Glu Pro 
    1190                 1195                 1200             


Met Ser  Pro Glu Gln Asp Glu  Asn Val Asn Ala Val  Pro Pro Ser 
    1205                 1210                 1215             


Ser Ala  Cys Asn Val Ser Lys  Glu Leu Leu Glu Ala  Asn Arg Glu 
    1220                 1225                 1230             


Ile Ser  Asp Ser Cys Pro Val  Tyr Pro Val Ile Thr  Ala Arg Leu 
    1235                 1240                 1245             


Ser Leu  Pro Glu Ser Thr Glu  Ser Phe His Glu Pro  Ser Gln Glu 
    1250                 1255                 1260             


Leu Lys  Phe Ser Val Glu Gln  Arg Asn Thr Arg Asn  Arg Glu Asn 
    1265                 1270                 1275             


Ser Pro  Ser Ser Gln Ser Ala  Gly Leu Ser Ser Ile  Asn Lys Glu 
    1280                 1285                 1290             


Gly Glu  Glu Pro Thr Lys Gly  Asn Ser Gly Ser Glu  Ala Cys Thr 
    1295                 1300                 1305             


Ser Ser  Phe Leu Arg Leu Ser  Phe Ala Ser Glu Thr  Pro Leu Glu 
    1310                 1315                 1320             


Lys Glu  Pro His Ser Pro Ala  Asp Gln Pro Glu Gln  Gln Ala Glu 
    1325                 1330                 1335             


Ser Thr  Leu Thr Ser Ala Glu  Thr Arg Gly Ser Lys  Lys Lys Lys 
    1340                 1345                 1350             


Lys Leu  Arg Lys Lys Lys Ser  Leu Arg Ala Ala His  Val Pro Glu 
    1355                 1360                 1365             


Asn Ser  Asp Thr Glu Gln Asp  Val Leu Thr Val Lys  Pro Val Arg 
    1370                 1375                 1380             


Lys Val  Lys Ala Gly Lys Leu  Ile Lys Gly Gly Lys  Val Thr Thr 
    1385                 1390                 1395             


Ser Thr  Trp Glu Asp Ser Arg  Thr Gly Arg Glu Gln  Glu Ser Val 
    1400                 1405                 1410             


Arg Asp  Glu Pro Asp Ser Asp  Ser Ser Leu Glu Val  Leu Glu Ile 
    1415                 1420                 1425             


Pro Asn  Pro Gln Leu Glu Val  Val Ala Ile Asp Ser  Ser Glu Ser 
    1430                 1435                 1440             


Gly Glu  Glu Lys Pro Asp Ser  Pro Ser Lys Lys Asp  Ile Trp Asn 
    1445                 1450                 1455             


Ser Thr  Glu Gln Asn Pro Leu  Glu Thr Ser Arg Ser  Gly Cys Asp 
    1460                 1465                 1470             


Glu Val  Ser Ser Thr Ser Glu  Ile Gly Thr Arg Tyr  Lys Asp Gly 
    1475                 1480                 1485             


Ile Pro  Val Ser Val Ala Glu  Thr Gln Thr Val Ile  Ser Ser Ile 
    1490                 1495                 1500             


Lys Gly  Ser Lys Asn Ser Ser  Glu Ile Ser Ser Glu  Pro Gly Asp 
    1505                 1510                 1515             


Asp Asp  Glu Pro Thr Glu Gly  Ser Phe Glu Gly His  Gln Ala Ala 
    1520                 1525                 1530             


Val Asn  Ala Ile Gln Ile Phe  Gly Asn Leu Leu Tyr  Thr Cys Ser 
    1535                 1540                 1545             


Ala Asp  Lys Thr Val Arg Val  Tyr Asn Leu Val Ser  Arg Lys Cys 
    1550                 1555                 1560             


Ile Gly  Val Phe Glu Gly His  Thr Ser Lys Val Asn  Cys Leu Leu 
    1565                 1570                 1575             


Val Thr  Gln Thr Ser Gly Lys  Asn Ala Ala Leu Tyr  Thr Gly Ser 
    1580                 1585                 1590             


Ser Asp  His Thr Ile Arg Cys  Tyr Asn Val Lys Ser  Arg Glu Cys 
    1595                 1600                 1605             


Val Glu  Gln Leu Gln Leu Glu  Asp Arg Val Leu Cys  Leu His Ser 
    1610                 1615                 1620             


Arg Trp  Arg Ile Leu Tyr Ala  Gly Leu Ala Asn Gly  Thr Val Val 
    1625                 1630                 1635             


Thr Phe  Asn Ile Lys Asn Asn  Lys Arg Leu Glu Ile  Phe Glu Cys 
    1640                 1645                 1650             


His Gly  Pro Arg Ala Val Ser  Cys Leu Ala Thr Ala  Gln Glu Gly 
    1655                 1660                 1665             


Ala Arg  Lys Leu Leu Val Val  Gly Ser Tyr Asp Cys  Thr Ile Ser 
    1670                 1675                 1680             


Val Arg  Asp Ala Arg Asn Gly  Leu Leu Leu Arg Thr  Leu Glu Gly 
    1685                 1690                 1695             


His Ser  Lys Thr Ile Leu Cys  Met Lys Val Val Asn  Asp Leu Val 
    1700                 1705                 1710             


Phe Ser  Gly Ser Ser Asp Gln  Ser Val His Ala His  Asn Ile His 
    1715                 1720                 1725             


Thr Gly  Glu Leu Val Arg Ile  Tyr Lys Gly His Asn  His Ala Val 
    1730                 1735                 1740             


Thr Val  Val Asn Ile Leu Gly  Lys Val Met Val Thr  Ala Cys Leu 
    1745                 1750                 1755             


Asp Lys  Phe Val Arg Val Tyr  Glu Leu Gln Ser His  Asp Arg Leu 
    1760                 1765                 1770             


Gln Val  Tyr Gly Gly His Lys  Asp Met Ile Met Cys  Met Thr Ile 
    1775                 1780                 1785             


His Lys  Ser Met Ile Tyr Thr  Gly Cys Tyr Asp Gly  Ser Ile Gln 
    1790                 1795                 1800             


Ala Val  Arg Leu Asn Leu Met  Gln Asn Tyr Arg Cys  Trp Trp His 
    1805                 1810                 1815             


Gly Cys  Ser Leu Ile Phe Gly  Val Val Asp His Leu  Lys Gln His 
    1820                 1825                 1830             


Leu Leu  Thr Asp His Thr Asn  Pro Asn Phe Gln Thr  Leu Lys Cys 
    1835                 1840                 1845             


Arg Trp  Lys Asn Cys Asp Ala  Phe Phe Thr Ala Arg  Lys Gly Ser 
    1850                 1855                 1860             


Lys Gln  Asp Ala Ala Gly His  Ile Glu Arg His Ala  Glu Asp Asp 
    1865                 1870                 1875             


Ser Lys  Ile Asp Ser 
    1880             


<210>  1353
<211>  1617
<212>  DNA
<213>  Homosapiens

<400>  1353
cctcacatga tccagtttaa tcctcctctt ctcccttcct gaagctgcac gctgcagtaa     60

gagcacagca gaaatgcaga caaaaggggg ccaaacatgg gcgagaaggg ctctgttgct    120

cggcatcctg tgggccactg cacatctgcc tctctcaggg acctccctgc cccaacgtct    180

cccaagggcc acaggaaata gcacccaatg tgttatttct ccatcatcgg agtttcccga    240

agggtttttc acgagacagg agcgcagaga tggaggcatc ataatctatt tcctaattat    300

cgtttacatg ttcatggcca tatctattgt ctgtgatgaa tacttcctac cctccctgga    360

aatcatcagt gaatcccttg gattgtctca ggatgttgca ggcacaactt tcatggcagc    420

gggcagttca gctcctgaat tagttactgc tttcctaggt gtatttatca caaagggaga    480

tattggcatt agcaccatcc ttggatctgc aatttataat ctccttggca tctgtgctgc    540

ctgtggtttg ctatctaata cggtctcaac actatcatgt tggcccctat tcagagactg    600

tgcagcgtac acaattagtg cagcagcagt tcttggtata atatatgaca accaagttta    660

ctggtatgaa ggggctttac tgcttttgat atatggattg tatgttttgg tgctgtgttt    720

tgacattaaa attaaccaat atattataaa gaaatgcagt ccttgctgcg cctgtcttgc    780

caaagctatg gagagaagtg aacaacagcc actgatgggc tgggaagatg aaggtcaacc    840

attcattcgt cggcaatcaa gaactgatag tggaatattt tatgaagatt ctggctactc    900

tcagctctct ataagtttac atggccttag tcaggtttct gaagatccac caagtgtttt    960

caacatgcct gaagcagact taaaaagaat tttttgggta ttatcccttc ctattattac   1020

attacttttt ctaaccacac cagattgtag aaaaaagttt tggaaaaact actttgtgat   1080

aacctttttc atgtctgcaa tatggatatc cgcatttaca tatatcctgg tttggatggt   1140

cacaattaca ggggaaacac tagaaattcc cgatacagta atgggcctta ctttattagc   1200

agcaggaaca agcataccag acacaattgc aagtgtgttg gttgcaagaa aagggaaagg   1260

agatatggct atgtctaaca tcgtgggatc caatgtgttt gatatgttgt gccttggtat   1320

tccatggttt attaaaactg catttataaa tggatcagct cctgcagaag taaacagcag   1380

aggactaact tacataacca tctctctcaa catttcaatt atttttcttt ttttagcagt   1440

tcacttcaat ggctggaaac tagacagaaa gttgggaata gtctgcctat tatcatactt   1500

ggggcttgct acattatcag ttctatatga acttggaatt attggaaata ataaaataag   1560

gggctgtgga ggttgatatt attaatagtg ttatgcagaa aatatgaatg gcaggga      1617


<210>  1354
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  1354

Met Gln Thr Lys Gly Gly Gln Thr Trp Ala Arg Arg Ala Leu Leu Leu 
1               5                   10                  15      


Gly Ile Leu Trp Ala Thr Ala His Leu Pro Leu Ser Gly Thr Ser Leu 
            20                  25                  30          


Pro Gln Arg Leu Pro Arg Ala Thr Gly Asn Ser Thr Gln Cys Val Ile 
        35                  40                  45              


Ser Pro Ser Ser Glu Phe Pro Glu Gly Phe Phe Thr Arg Gln Glu Arg 
    50                  55                  60                  


Arg Asp Gly Gly Ile Ile Ile Tyr Phe Leu Ile Ile Val Tyr Met Phe 
65                  70                  75                  80  


Met Ala Ile Ser Ile Val Cys Asp Glu Tyr Phe Leu Pro Ser Leu Glu 
                85                  90                  95      


Ile Ile Ser Glu Ser Leu Gly Leu Ser Gln Asp Val Ala Gly Thr Thr 
            100                 105                 110         


Phe Met Ala Ala Gly Ser Ser Ala Pro Glu Leu Val Thr Ala Phe Leu 
        115                 120                 125             


Gly Val Phe Ile Thr Lys Gly Asp Ile Gly Ile Ser Thr Ile Leu Gly 
    130                 135                 140                 


Ser Ala Ile Tyr Asn Leu Leu Gly Ile Cys Ala Ala Cys Gly Leu Leu 
145                 150                 155                 160 


Ser Asn Thr Val Ser Thr Leu Ser Cys Trp Pro Leu Phe Arg Asp Cys 
                165                 170                 175     


Ala Ala Tyr Thr Ile Ser Ala Ala Ala Val Leu Gly Ile Ile Tyr Asp 
            180                 185                 190         


Asn Gln Val Tyr Trp Tyr Glu Gly Ala Leu Leu Leu Leu Ile Tyr Gly 
        195                 200                 205             


Leu Tyr Val Leu Val Leu Cys Phe Asp Ile Lys Ile Asn Gln Tyr Ile 
    210                 215                 220                 


Ile Lys Lys Cys Ser Pro Cys Cys Ala Cys Leu Ala Lys Ala Met Glu 
225                 230                 235                 240 


Arg Ser Glu Gln Gln Pro Leu Met Gly Trp Glu Asp Glu Gly Gln Pro 
                245                 250                 255     


Phe Ile Arg Arg Gln Ser Arg Thr Asp Ser Gly Ile Phe Tyr Glu Asp 
            260                 265                 270         


Ser Gly Tyr Ser Gln Leu Ser Ile Ser Leu His Gly Leu Ser Gln Val 
        275                 280                 285             


Ser Glu Asp Pro Pro Ser Val Phe Asn Met Pro Glu Ala Asp Leu Lys 
    290                 295                 300                 


Arg Ile Phe Trp Val Leu Ser Leu Pro Ile Ile Thr Leu Leu Phe Leu 
305                 310                 315                 320 


Thr Thr Pro Asp Cys Arg Lys Lys Phe Trp Lys Asn Tyr Phe Val Ile 
                325                 330                 335     


Thr Phe Phe Met Ser Ala Ile Trp Ile Ser Ala Phe Thr Tyr Ile Leu 
            340                 345                 350         


Val Trp Met Val Thr Ile Thr Gly Glu Thr Leu Glu Ile Pro Asp Thr 
        355                 360                 365             


Val Met Gly Leu Thr Leu Leu Ala Ala Gly Thr Ser Ile Pro Asp Thr 
    370                 375                 380                 


Ile Ala Ser Val Leu Val Ala Arg Lys Gly Lys Gly Asp Met Ala Met 
385                 390                 395                 400 


Ser Asn Ile Val Gly Ser Asn Val Phe Asp Met Leu Cys Leu Gly Ile 
                405                 410                 415     


Pro Trp Phe Ile Lys Thr Ala Phe Ile Asn Gly Ser Ala Pro Ala Glu 
            420                 425                 430         


Val Asn Ser Arg Gly Leu Thr Tyr Ile Thr Ile Ser Leu Asn Ile Ser 
        435                 440                 445             


Ile Ile Phe Leu Phe Leu Ala Val His Phe Asn Gly Trp Lys Leu Asp 
    450                 455                 460                 


Arg Lys Leu Gly Ile Val Cys Leu Leu Ser Tyr Leu Gly Leu Ala Thr 
465                 470                 475                 480 


Leu Ser Val Leu Tyr Glu Leu Gly Ile Ile Gly Asn Asn Lys Ile Arg 
                485                 490                 495     


Gly Cys Gly Gly 
            500 


<210>  1355
<211>  4544
<212>  DNA
<213>  Homosapiens

<400>  1355
cgccattgtc gcgctcggag cccctcagct caggcggccg aggcggaggc agcggcggcg     60

ggatggcgga cgccaacaag gccgaggtgc ccggggccac tggtggcgac agcccgcacc    120

tgcagcccgc agagccgccg ggcgagccgc ggcgagagcc gcaccccgcg gaggcggaga    180

agcagcagcc gcagcacagc agcagctcca atggcgttaa aatggagaat gatgaatcag    240

caaaagaaga gaaatctgac ttaaaggaaa aatctacagg aagtaagaag gccaatagat    300

ttcatcctta ttcaaaagac aagaattcgg gcactggaga aaagaagggt ccaaatcgta    360

acagagtttt cattagcaac atcccatatg acatgaaatg gcaagctatt aaagatctaa    420

tgagagagaa agttggtgag gttacatacg tggagctctt taaggatgcg gaaggaaaat    480

caaggggttg tggtgtggtt gaattcaaag atgaagaatt tgtaaagaaa gccctagaaa    540

ctatgaacaa atatgatctt agtggaagac cccttaatat taaagaggat cctgatggag    600

aaaatgctcg tagggcattg cagcgaacag gaggatcatt tccaggagga cacgtccctg    660

atatgggatc agggttgatg aatttaccac cttccatact caataatcca aacattcctc    720

ctgaagtcat cagtaatttg caggccggta gacttggttc cacaattttt gttgccaatc    780

ttgacttcaa agttggttgg aagaagctaa aggaagtgtt cagcatagct ggaactgtga    840

agcgggcaga tattaaagaa gacaaagatg gcaagagcag aggaatgggc actgtcactt    900

ttgagcaagc aattgaagca gttcaagcaa tttctatgtt caatgggcag tttttatttg    960

atagacctat gcatgtgaaa atggatgaca agtctgttcc tcatgaagag taccgttcac   1020

atgatggtaa aacaccacaa ttaccacgtg gtcttggagg cattgggatg ggacttggtc   1080

cgggtggaca gcctattagt gccagccagt tgaacatagg tggagtaatg ggaaatttag   1140

gtccaggtgg tatgggaatg gatggtccag gttttggagg aatgaataga attggaggag   1200

gaatagggtt tggtggtctg gaagcaatga atagcatggg aggatttgga ggagttggcc   1260

gaatgggaga gctgtaccgt ggtgcgatga ctagtagcat ggagcgagat tttggacgtg   1320

gtgatattgg aataaatcga ggctttggag attcctttgg tagacttggc agtgcaatga   1380

ttggagggtt tgcaggaaga ataggatctt ctaacatggg tccagtagga tctggaataa   1440

gtggtggaat gggtagcatg aacagtgtga ctggaggaat ggggatggga ctggaccgga   1500

tgagttccag ctttgataga atgggaccag gtataggagc tatactggaa aggagcatcg   1560

atatggatcg aggattttta tcgggtccaa tgggaagcgg aatgagagag agaataggct   1620

ccaaaggcaa ccagatattt gtcagaaatc taccttttga cttgacttgg cagaaactaa   1680

aagagaaatt cagtcagtgt ggtcatgtaa tgtttgcaga aataaaaatg gagaatggaa   1740

agtcaaaagg ctgtggaaca gtcagatttg actccccaga atcagctgaa aaagcctgca   1800

gaataatgaa tggcataaaa atcagtggca gagaaattga tgttcgcttg gatcgtaatg   1860

cataatttca agccatggtt ggaacattcc tacatctgtt ttgctgaatc tcctagtaaa   1920

agtcattttt ttaaagtaat attgtatgct tacaaaagct gtaaaaatga acttttaaaa   1980

ctcccaccag cttttaacag tataatgtta aaaatatact gtaatttttg ttaatctcaa   2040

gtttgggttt ttaaagacag caagtctggt cattcagttt aaatgaatgg ttatactgtt   2100

tttaatgaaa taagccattt tcttgttgtt ttcagtacta catagttgga tttgtttgtt   2160

ctagtttctc cagtttttgt caacttattg tatggtaaaa catagatttt ttccccccaa   2220

acttctgttt tataatatgt aatttttcat gaaaagaaag ggctcagaaa aattaggatg   2280

tgattttggt tggttttaaa ttactgtaag ttttagattc taaggttcaa gatttttaaa   2340

atttgattta aatgaagaaa tggatttttc tctctgcccc tccctgccat tcatattttc   2400

tgcataacac tattaataat atcaacctcc acagcccctt attttattat ttccaataat   2460

tccaagttca tatagaactg ataatgtagc aagccccaag tatgataata ggcagactat   2520

tcccaacttt ctgtctagtt tccagccatt gaagtgaact gctaaaaaaa gaaaaataat   2580

tgaaatgttg agagagatgg ttatgtaagt tagtcctctg ctgtttactt ctgcaggagc   2640

tgatccattt ataaatgcag ttttaataaa ccatggaata ccaaggcaca acatatcaaa   2700

cacattggat cccacgatgt tagacatagc catatctcct ttccctacaa aagaaaagca   2760

tactgttaaa atgtgcttac caatactgtg ttttattaat aatcttcata agaaaagaaa   2820

cactggatac ttttttgttg ttgattcgtt ttgaaaaatt gttgttagag caaaagtctt   2880

actgaatttg tatttttaaa tttttcttgg gttagtattt aaagtcttaa catttattta   2940

ataattatat ttattaaacc atttttcaat aaggtatata gcttatttgt tgcttttcat   3000

tgtaatttaa catggttaat ggttaattac tatttaacac acatttcaaa tgaatattat   3060

ttgggggatt agattgagtg aaattaacct gctattaaat agtaaacttt tcctctggag   3120

tcactttttt cccccttcaa agtatgttac tgaggaagta aacttttttt tttttttttg   3180

gtttttgttt tttgagacac agtctcgctc tgttgcccag gctgctggag tgccgtggcg   3240

caatctcggc tcactgcaac ctccgcctcc tggattcaaa caattctcct gcctcagcct   3300

cctgagtagc tgggattaca ggcacatgcc accacgcccg gctaattttt gtatttttag   3360

tagagactgg gtttcaccat gttggtcagg ctggtctcaa actcctgacc tcgtgatcca   3420

cccgcctcgg cctcccaaaa tcctgggatt acaggcgcga gccaccacac ccggccggaa   3480

gtaaacattt ttaaagctac ttttactcat tctagccttg tagaatgacc attgcagctt   3540

gagggaccta gttcttacct tttcttgcaa ccaacacact tgcaattgtg tctggtatgc   3600

ttgttcctgc tgctaataaa gtaaggccca ttactgtatc gggaatttct agtgtttccc   3660

ctgtaataaa cagatatttc aagttacaaa tcttaaagat tcactaacca tcctttgcag   3720

ttattttgga tatttccttc gtgaacaaaa ataaaatagg cacatttaga attcagagcc   3780

aatatgtgct tgcttattag ttttttagct agcaacatat ttgaatcagg ctggtaattc   3840

gggtaaccca ggtagcacag atttttaatg acatatctaa agatacgtaa cagctaaaat   3900

tctgccagtg agaaattttc ctgtttgata ttcttacaaa agatgtttat gtccaccatt   3960

atctcatcag ggctgtgctg aatatttgat aatgagactg atcattccgc tttttctttc   4020

ttaaaaatat tagtcagagt taagcaaatt aattatagct atctttaagc tataaatgtg   4080

ttaacatgta tatataccat ttattatgtt ctactttagt gatatacctt aatttagtgg   4140

gctttggcag ggcgggggag ggggaacgtt cattaatctc tgaggaaaac aaaacctgtt   4200

ttctacttga gtctaacata tggtcccaat ttattaatac ttctgttaaa tttgatgtca   4260

ggtcaacatt tttcagaaat gtatttattc tcagaaacag aaccagagag aagttaaaca   4320

aaaggttatg taactgttcc tttaatgttg taattgaaaa cttggtttag cgtctttttt   4380

ttctttctct tttttttttc ttaaaatgcc aactaaaata attagaaagt agcttattta   4440

ttgcatgctt atacattgat attggaattg gaattggttg ttaatttctg ttactggctt   4500

tgctagaatt catatgtgca taaataacac taatatttat catc                    4544


<210>  1356
<211>  600
<212>  PRT
<213>  Homosapiens

<400>  1356

Met Ala Asp Ala Asn Lys Ala Glu Val Pro Gly Ala Thr Gly Gly Asp 
1               5                   10                  15      


Ser Pro His Leu Gln Pro Ala Glu Pro Pro Gly Glu Pro Arg Arg Glu 
            20                  25                  30          


Pro His Pro Ala Glu Ala Glu Lys Gln Gln Pro Gln His Ser Ser Ser 
        35                  40                  45              


Ser Asn Gly Val Lys Met Glu Asn Asp Glu Ser Ala Lys Glu Glu Lys 
    50                  55                  60                  


Ser Asp Leu Lys Glu Lys Ser Thr Gly Ser Lys Lys Ala Asn Arg Phe 
65                  70                  75                  80  


His Pro Tyr Ser Lys Asp Lys Asn Ser Gly Thr Gly Glu Lys Lys Gly 
                85                  90                  95      


Pro Asn Arg Asn Arg Val Phe Ile Ser Asn Ile Pro Tyr Asp Met Lys 
            100                 105                 110         


Trp Gln Ala Ile Lys Asp Leu Met Arg Glu Lys Val Gly Glu Val Thr 
        115                 120                 125             


Tyr Val Glu Leu Phe Lys Asp Ala Glu Gly Lys Ser Arg Gly Cys Gly 
    130                 135                 140                 


Val Val Glu Phe Lys Asp Glu Glu Phe Val Lys Lys Ala Leu Glu Thr 
145                 150                 155                 160 


Met Asn Lys Tyr Asp Leu Ser Gly Arg Pro Leu Asn Ile Lys Glu Asp 
                165                 170                 175     


Pro Asp Gly Glu Asn Ala Arg Arg Ala Leu Gln Arg Thr Gly Gly Ser 
            180                 185                 190         


Phe Pro Gly Gly His Val Pro Asp Met Gly Ser Gly Leu Met Asn Leu 
        195                 200                 205             


Pro Pro Ser Ile Leu Asn Asn Pro Asn Ile Pro Pro Glu Val Ile Ser 
    210                 215                 220                 


Asn Leu Gln Ala Gly Arg Leu Gly Ser Thr Ile Phe Val Ala Asn Leu 
225                 230                 235                 240 


Asp Phe Lys Val Gly Trp Lys Lys Leu Lys Glu Val Phe Ser Ile Ala 
                245                 250                 255     


Gly Thr Val Lys Arg Ala Asp Ile Lys Glu Asp Lys Asp Gly Lys Ser 
            260                 265                 270         


Arg Gly Met Gly Thr Val Thr Phe Glu Gln Ala Ile Glu Ala Val Gln 
        275                 280                 285             


Ala Ile Ser Met Phe Asn Gly Gln Phe Leu Phe Asp Arg Pro Met His 
    290                 295                 300                 


Val Lys Met Asp Asp Lys Ser Val Pro His Glu Glu Tyr Arg Ser His 
305                 310                 315                 320 


Asp Gly Lys Thr Pro Gln Leu Pro Arg Gly Leu Gly Gly Ile Gly Met 
                325                 330                 335     


Gly Leu Gly Pro Gly Gly Gln Pro Ile Ser Ala Ser Gln Leu Asn Ile 
            340                 345                 350         


Gly Gly Val Met Gly Asn Leu Gly Pro Gly Gly Met Gly Met Asp Gly 
        355                 360                 365             


Pro Gly Phe Gly Gly Met Asn Arg Ile Gly Gly Gly Ile Gly Phe Gly 
    370                 375                 380                 


Gly Leu Glu Ala Met Asn Ser Met Gly Gly Phe Gly Gly Val Gly Arg 
385                 390                 395                 400 


Met Gly Glu Leu Tyr Arg Gly Ala Met Thr Ser Ser Met Glu Arg Asp 
                405                 410                 415     


Phe Gly Arg Gly Asp Ile Gly Ile Asn Arg Gly Phe Gly Asp Ser Phe 
            420                 425                 430         


Gly Arg Leu Gly Ser Ala Met Ile Gly Gly Phe Ala Gly Arg Ile Gly 
        435                 440                 445             


Ser Ser Asn Met Gly Pro Val Gly Ser Gly Ile Ser Gly Gly Met Gly 
    450                 455                 460                 


Ser Met Asn Ser Val Thr Gly Gly Met Gly Met Gly Leu Asp Arg Met 
465                 470                 475                 480 


Ser Ser Ser Phe Asp Arg Met Gly Pro Gly Ile Gly Ala Ile Leu Glu 
                485                 490                 495     


Arg Ser Ile Asp Met Asp Arg Gly Phe Leu Ser Gly Pro Met Gly Ser 
            500                 505                 510         


Gly Met Arg Glu Arg Ile Gly Ser Lys Gly Asn Gln Ile Phe Val Arg 
        515                 520                 525             


Asn Leu Pro Phe Asp Leu Thr Trp Gln Lys Leu Lys Glu Lys Phe Ser 
    530                 535                 540                 


Gln Cys Gly His Val Met Phe Ala Glu Ile Lys Met Glu Asn Gly Lys 
545                 550                 555                 560 


Ser Lys Gly Cys Gly Thr Val Arg Phe Asp Ser Pro Glu Ser Ala Glu 
                565                 570                 575     


Lys Ala Cys Arg Ile Met Asn Gly Ile Lys Ile Ser Gly Arg Glu Ile 
            580                 585                 590         


Asp Val Arg Leu Asp Arg Asn Ala 
        595                 600 


<210>  1357
<211>  2921
<212>  DNA
<213>  Homosapiens

<400>  1357
atgcccgcag cacagccagg aatgcagcaa agagagcaaa acaaggattt cagcagtaaa     60

tcaattaaac cctcactgcc ttatctcaca tacacacaca gatgctgcca cagacacacg    120

cgagcgcaaa tatttacaca ctgccacacc gaagaaatcc atgcacgttt tcctgcaaac    180

gcgcgcgcgc acacgtactt cggcgggcgc ccacgtcctc tgtctcacca acagacacag    240

acatttacac ttctaggcca ggaaagcgct aaccagggcc ctgtgactct acgcaggttc    300

cagaacacgc cttctacatt tgttactgaa ccgatcagcg aacacagaca aacgtgccaa    360

cacttaagtc tactggctgg acttcatctc catggcaaca agcatggaag gcaaagagtt    420

gattccagaa ggaactgtga agagccacaa caatgtgcca gtgaataatg agtagtacct    480

actgtggcaa ctcttcagct aagatgagtg tcaacgaagt atcagctttc tcattgactc    540

tggagcaaaa aactggcttt gcttttgttg ggattttgtg tatcttcttg ggacttctta    600

ttatccgatg cttcaaaatc ctgctagacc catatagtag catgccttcc tctacatggg    660

aagatgaagt tgaagagttt gataaaggga catttgaata tgcactcgcg tgagagttcc    720

agctatatgg tttttatggt tgtgccatcg ggacacattc tggatacaat tgtaactacc    780

ttgagggtgt gggagagagg ctcattttgt tcagtgaatt caataaacat ctgtgactaa    840

tttcttcacc atgctgtgta aatgataaac tattgttggg attcctcact ttcctctgtt    900

cccacttaga ggtttccaat gaatagagca taaggatggc tgccgccatg tttaccatct    960

ttattcttat cttgaacaac tgccttgaat ttctgcttcc tttcttgtgc taataaactg   1020

tgccaaaggc atcttgctct ctcccctctg aaaagcccag gcatcccctc cacattcctg   1080

actcagaccc ctttagcttt agtgagtcag gtcttaaaca gagaatttag tccaaagaat   1140

aatcaaaata ttatttgtct aataataacc ataggcccaa aaggttcaca ggtgaaaaaa   1200

tatctcaaaa atctaacacc caaagcctac aagtagtcac aggccctaaa gctccccaaa   1260

tttcacagag ccctgaccct cctatctctt ctgtttgtcg aatctcttgc agtaaaatcc   1320

catagcttgg aatccaaacc agatctgcct catactgatg ctccctcccc taccccttgc   1380

ataaatagaa tttaaaaggg agtttccagc atgacctagt ggaaagagta ctctaagcag   1440

aaacaaagac agtctcagct gtgccaccag tagagctatg ctctaatggg taagtcatct   1500

aatctctgtg agcttcagtg aagagtagtg ttaacatcct tttcaattct agtgccctat   1560

gaatgctaca aatgtatctg aaaacccaga gatctgaaat gaatgaggat ttaagatatc   1620

atgaaaagtt tttcagatta ggagcctaaa ctcagagatt tgaattctaa tgttagctta   1680

gccaagaact agctttatga cctagaaagt tacctaaagg gaacctatat tgcacaacaa   1740

gaattaagaa acccatcctg catgtcttca gcaatattga gagggccaat tagatataat   1800

gaatgtgaaa gcattttgta aaccataaaa cagtatctaa acataccttg ctatcaatat   1860

ttattgtcct catcagtagc agtaatagag attctcaaac cctaagaagc aatggcttag   1920

tgtaaattat tcaatctctc tagtatttca ttctcttcaa ttgagaaata aaaagataaa   1980

attatatagt tctaaattct ttccaactac aaacttctga ctctctatga gtcagaatgg   2040

aggaacatag caggagataa atacaaaaat atttatgtcc tttgaaaaca cagaactgca   2100

aaacatacca tgaaggaaca agactaatat taccaagagg tagcactaag ttagttactt   2160

tcaatttatt tgatactctt ataaattctt tgagttggag actactattt ccattttatt   2220

tttaatctta attttgcaga agagaaactg aagctaagag aaattaacta gcttcccaag   2280

gtcaccatag ctagggaatg gttatgttag ggattgaact tgggcagttt gatttctgct   2340

gtatccctag acactgtcct caacacttct acatagctta taggcatggt tactgctcag   2400

gtctatggaa ttccaaaacc agctgtctct gtgagattcc ttgatgcttt ccatctcata   2460

atagatttag aacatatctg ttattagcta tggatcttct ggaccaaatc ctcacctcaa   2520

ggaggctctc tgtaccccag ttggttcaag agtgtaggcc tggtacacct catagccagt   2580

tagtaacttg gcccaagaac aggccactgg gccaagttca actgaacata ctgaaaattg   2640

tgtgtgccag gaaactaggt ctctttgttg accaaggctt ttaaagtacc agatgtttca   2700

tttgtctccc agagaagaca cccaccaaga ccctccattt tgatgactag aacaaaccaa   2760

ggccagatct ttatttcaaa ggaagaaaga cctctacaac caagaaaact ttatgaaata   2820

tgagcattgt ttctggaagt tcaactccca taagcttttc aagtatatta actctaccat   2880

aatattattt ccaaatccac taaagaaaaa ttctattaac c                       2921


<210>  1358
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  1358

Met Pro Ala Ala Gln Pro Gly Met Gln Gln Arg Glu Gln Asn Lys Asp 
1               5                   10                  15      


Phe Ser Ser Lys Ser Ile Lys Pro Ser Leu Pro Tyr Leu Thr Tyr Thr 
            20                  25                  30          


His Arg Cys Cys His Arg His Thr Arg Ala Gln Ile Phe Thr His Cys 
        35                  40                  45              


His Thr Glu Glu Ile His Ala Arg Phe Pro Ala Asn Ala Arg Ala His 
    50                  55                  60                  


Thr Tyr Phe Gly Gly Arg Pro Arg Pro Leu Ser His Gln Gln Thr Gln 
65                  70                  75                  80  


Thr Phe Thr Leu Leu Gly Gln Glu Ser Ala Asn Gln Gly Pro Val Thr 
                85                  90                  95      


Leu Arg Arg Phe Gln Asn Thr Pro Ser Thr Phe Val Thr Glu Pro Ile 
            100                 105                 110         


Ser Glu His Arg Gln Thr Cys Gln His Leu Ser Leu Leu Ala Gly Leu 
        115                 120                 125             


His Leu His Gly Asn Lys His Gly Arg Gln Arg Val Asp Ser Arg Arg 
    130                 135                 140                 


Asn Cys Glu Glu Pro Gln Gln Cys Ala Ser Glu 
145                 150                 155 


<210>  1359
<211>  3362
<212>  DNA
<213>  Homosapiens

<400>  1359
aaaaaatcaa ttttggaaga tgtcactgaa caactcttcc aatgtatttc tggattcagt     60

gcccagtaat accaatcgct ttcaagttag tgtcataaat gagaaccatg agagcagtgc    120

agctgcagat gacaatactg acccaccaca ttatgaagaa acctcttttg gggatgaagc    180

tcagaaaaga ctcagaatca gctttaggcc tgggaatcag gagtgctatg acaatttcct    240

ccacagtgga gaaactgcta aaacagatgc cagttttcac gcttatgatt ctcacacaaa    300

cacatactat ctacaaactt ttggccacaa caccatggat gccgttccca agatagagta    360

ctatcgtaac accggcagca tcagtgggcc caaggtcaac cgacccagcc tgcttgagat    420

tcacgagcaa ctcgcaaaga atgtggcagt caccccaagt tcagctgaca gagttgctaa    480

cggtgatggg atacctggag atgaacaagc tgaaaataag gaagatgatc aagctggtgt    540

tgtgaagttt ggatgggtga aaggtgtgct ggtaagatgc atgctgaaca tctggggagt    600

catgctcttc attcgcctct cctggattgt tggagaagct ggaattggtc ttggagttat    660

catcattggc ctatccacca tagtaacgac aatcacaggt atgtccacgt ctgctattgc    720

cacgaacgga gttgttagag gaggtggggc ctactatctt atttccagaa gtttagggcc    780

cgagttcggt gggtcaatag gcctgatctt tgcttttgct aatgcagtgg ctgttgctat    840

gtatgtggtg ggattcgctg aaactgtagt agatctactt aaggagagtg attcgatgat    900

ggtggatcca accaatgaca tccggattat aggctccatc acagtggtga ttcttctagg    960

aatttcagta gctggaatgg aatgggaggc aaaggcccaa gtcattcttc tggtcattct   1020

tctaattgct attgcaaact tcttcattgg aactgtcatt ccatccaaca atgagaaaaa   1080

gtccagaggt ttctttaatt accaagcatc aatatttgca gaaaactttg ggccacgctt   1140

cacaaagggt gaaggcttct tctctgtctt tgccattttt ttcccagcag ctactgggat   1200

tcttgctggt gccaatatct caggagattt ggaggatccc caagatgcca tccccagagg   1260

aaccatgctg gccattttca tcaccactgt tgcctactta ggggttgcaa tttgtgtagg   1320

ggcctgtgtg gtccgagatg ccaccgggaa catgaatgac accatcattt ctgggatgaa   1380

ctgcaatggt tcagcagcat gtgggttggg ctatgacttc tcaagatgtc gacatgaacc   1440

atgtcagtac gggctgatga acaatttcca ggtcatgagc atggtatcag ggttcggccc   1500

cctcatcact gcgggaatct tttctgcaac actctcctcc gccctggcct cccttgtcag   1560

cgcacccaaa gtgttccagg ctctgtgcaa ggacaacatc tacaaagccc tgcagttttt   1620

tgcaaaggga tatgggaaaa acaatgaacc cctgagagga tatattctca cttttcttat   1680

agccatggca tttattctta ttgcggaact gaacaccatt gctcccatca tctccaactt   1740

tttcctggcc tcatatgcac ttattaattt ctcctgcttc catgcctctt atgccaaatc   1800

tccaggatgg agacctgcgt atggaattta caacatgtgg gtatctcttt ttggagctgt   1860

tttgtgctgt gcagtcatgt ttgtcatcaa ctggtgggca gctgtcatca cctatgtcat   1920

tgaattcttc ctttacgtct atgtgacttg taagaagcca gatgtgaact ggggctcctc   1980

cacacaggct ctttcctacg tgagtgcttt agacaatgct ctggaattaa ccacagtgga   2040

agaccacgta aaaaacttca ggccccagtg cattgtctta acagggggac ccatgacaag   2100

acctgctctc ctggacataa ctcacgcctt taccaagaac agtggccttt gcatctgctg   2160

tgaagtcttt gtgggaccgc gcaaactgtg tgttaaggag atgaacagtg gcatggcgaa   2220

aaaacaggcc tggcttataa agaacaaaat caaggctttt tatgctgcag tggcggcaga   2280

ctgtttcagg gatggtgtcc gaagtcttct tcaggcctca ggcttaggaa gaatgaaacc   2340

aaacactctg gtgattggat ataagaaaaa ctggaggaaa gctcccttga cagagattga   2400

gaactacgtg ggaatcatac atgatgcatt tgattttgag attggcgtgg ttatagtcag   2460

aatcagccaa ggatttgaca tctctcaggt tcttcaggtg caagaggaat tagagagatt   2520

agaacaggag agactagcat tggaagcgac tatcaaagat aatgagtgtg aagaggaaag   2580

tggaggcatc cgaggcttgt ttaaaaaagc tggcaagttg aacattacta agacaacgcc   2640

taaaaaagat ggcagcatta acacaagcca gtcgatgcat gtgggagagt tcaaccagaa   2700

actggtggaa gccagcactc aatttaaaaa gaaacaagaa aaaggcacaa ttgatgtttg   2760

gtggttgttt gatgatggag ggttaacact tcttatcccc tatatcttaa ctctcagaaa   2820

aaaatggaaa gactgtaaat taagaatcta tgtgggaggg aagatcaacc gcattgaaga   2880

agaaaaaatt gcaatggctt cccttctgag caaatttagg ataaaatttg cagacatcca   2940

tatcatcggt gacatcaaca ttaggccaaa caaagagagc tggaaagtct ttgaagagat   3000

gattgaacca tatcgtctcc atgaaagctg caaagattta acaactgctg agaaattaaa   3060

aagagaaact ccgtggaaaa ttacagatgc agaactggaa gcagtcaagg aaaagagtta   3120

ccgccaagtt cgactgaatg aactcttaca ggagcactcc agagctgcta atctcattgt   3180

cctgagcctt cccgtggcaa gaaagggatc catatcggat ttgttgtata tggcttggtt   3240

ggaaatcctc acaaagaacc tcccacctgt cttactagtt agaggaaatc acaaaaatgt   3300

cttgacattt tactcttaaa acatgaaaga ttggaataca ttttaactta atgtaatgca   3360

ta                                                                  3362


<210>  1360
<211>  1099
<212>  PRT
<213>  Homosapiens

<400>  1360

Met Ser Leu Asn Asn Ser Ser Asn Val Phe Leu Asp Ser Val Pro Ser 
1               5                   10                  15      


Asn Thr Asn Arg Phe Gln Val Ser Val Ile Asn Glu Asn His Glu Ser 
            20                  25                  30          


Ser Ala Ala Ala Asp Asp Asn Thr Asp Pro Pro His Tyr Glu Glu Thr 
        35                  40                  45              


Ser Phe Gly Asp Glu Ala Gln Lys Arg Leu Arg Ile Ser Phe Arg Pro 
    50                  55                  60                  


Gly Asn Gln Glu Cys Tyr Asp Asn Phe Leu His Ser Gly Glu Thr Ala 
65                  70                  75                  80  


Lys Thr Asp Ala Ser Phe His Ala Tyr Asp Ser His Thr Asn Thr Tyr 
                85                  90                  95      


Tyr Leu Gln Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Lys Ile 
            100                 105                 110         


Glu Tyr Tyr Arg Asn Thr Gly Ser Ile Ser Gly Pro Lys Val Asn Arg 
        115                 120                 125             


Pro Ser Leu Leu Glu Ile His Glu Gln Leu Ala Lys Asn Val Ala Val 
    130                 135                 140                 


Thr Pro Ser Ser Ala Asp Arg Val Ala Asn Gly Asp Gly Ile Pro Gly 
145                 150                 155                 160 


Asp Glu Gln Ala Glu Asn Lys Glu Asp Asp Gln Ala Gly Val Val Lys 
                165                 170                 175     


Phe Gly Trp Val Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp 
            180                 185                 190         


Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly Glu Ala Gly 
        195                 200                 205             


Ile Gly Leu Gly Val Ile Ile Ile Gly Leu Ser Thr Ile Val Thr Thr 
    210                 215                 220                 


Ile Thr Gly Met Ser Thr Ser Ala Ile Ala Thr Asn Gly Val Val Arg 
225                 230                 235                 240 


Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe 
                245                 250                 255     


Gly Gly Ser Ile Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val 
            260                 265                 270         


Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Asp Leu Leu Lys 
        275                 280                 285             


Glu Ser Asp Ser Met Met Val Asp Pro Thr Asn Asp Ile Arg Ile Ile 
    290                 295                 300                 


Gly Ser Ile Thr Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met 
305                 310                 315                 320 


Glu Trp Glu Ala Lys Ala Gln Val Ile Leu Leu Val Ile Leu Leu Ile 
                325                 330                 335     


Ala Ile Ala Asn Phe Phe Ile Gly Thr Val Ile Pro Ser Asn Asn Glu 
            340                 345                 350         


Lys Lys Ser Arg Gly Phe Phe Asn Tyr Gln Ala Ser Ile Phe Ala Glu 
        355                 360                 365             


Asn Phe Gly Pro Arg Phe Thr Lys Gly Glu Gly Phe Phe Ser Val Phe 
    370                 375                 380                 


Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile 
385                 390                 395                 400 


Ser Gly Asp Leu Glu Asp Pro Gln Asp Ala Ile Pro Arg Gly Thr Met 
                405                 410                 415     


Leu Ala Ile Phe Ile Thr Thr Val Ala Tyr Leu Gly Val Ala Ile Cys 
            420                 425                 430         


Val Gly Ala Cys Val Val Arg Asp Ala Thr Gly Asn Met Asn Asp Thr 
        435                 440                 445             


Ile Ile Ser Gly Met Asn Cys Asn Gly Ser Ala Ala Cys Gly Leu Gly 
    450                 455                 460                 


Tyr Asp Phe Ser Arg Cys Arg His Glu Pro Cys Gln Tyr Gly Leu Met 
465                 470                 475                 480 


Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Gly Pro Leu Ile 
                485                 490                 495     


Thr Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu 
            500                 505                 510         


Val Ser Ala Pro Lys Val Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr 
        515                 520                 525             


Lys Ala Leu Gln Phe Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro 
    530                 535                 540                 


Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Met Ala Phe Ile Leu 
545                 550                 555                 560 


Ile Ala Glu Leu Asn Thr Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu 
                565                 570                 575     


Ala Ser Tyr Ala Leu Ile Asn Phe Ser Cys Phe His Ala Ser Tyr Ala 
            580                 585                 590         


Lys Ser Pro Gly Trp Arg Pro Ala Tyr Gly Ile Tyr Asn Met Trp Val 
        595                 600                 605             


Ser Leu Phe Gly Ala Val Leu Cys Cys Ala Val Met Phe Val Ile Asn 
    610                 615                 620                 


Trp Trp Ala Ala Val Ile Thr Tyr Val Ile Glu Phe Phe Leu Tyr Val 
625                 630                 635                 640 


Tyr Val Thr Cys Lys Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln 
                645                 650                 655     


Ala Leu Ser Tyr Val Ser Ala Leu Asp Asn Ala Leu Glu Leu Thr Thr 
            660                 665                 670         


Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Ile Val Leu Thr 
        675                 680                 685             


Gly Gly Pro Met Thr Arg Pro Ala Leu Leu Asp Ile Thr His Ala Phe 
    690                 695                 700                 


Thr Lys Asn Ser Gly Leu Cys Ile Cys Cys Glu Val Phe Val Gly Pro 
705                 710                 715                 720 


Arg Lys Leu Cys Val Lys Glu Met Asn Ser Gly Met Ala Lys Lys Gln 
                725                 730                 735     


Ala Trp Leu Ile Lys Asn Lys Ile Lys Ala Phe Tyr Ala Ala Val Ala 
            740                 745                 750         


Ala Asp Cys Phe Arg Asp Gly Val Arg Ser Leu Leu Gln Ala Ser Gly 
        755                 760                 765             


Leu Gly Arg Met Lys Pro Asn Thr Leu Val Ile Gly Tyr Lys Lys Asn 
    770                 775                 780                 


Trp Arg Lys Ala Pro Leu Thr Glu Ile Glu Asn Tyr Val Gly Ile Ile 
785                 790                 795                 800 


His Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val Arg Ile Ser 
                805                 810                 815     


Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu Glu Leu Glu 
            820                 825                 830         


Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile Lys Asp Asn 
        835                 840                 845             


Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe Lys Lys Ala 
    850                 855                 860                 


Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp Gly Ser Ile 
865                 870                 875                 880 


Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln Lys Leu Val 
                885                 890                 895     


Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly Thr Ile Asp 
            900                 905                 910         


Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr 
        915                 920                 925             


Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu Arg Ile Tyr 
    930                 935                 940                 


Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile Ala Met Ala 
945                 950                 955                 960 


Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile His Ile Ile 
                965                 970                 975     


Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys Val Phe Glu 
            980                 985                 990         


Glu Met Ile Glu Pro Tyr Arg Leu  His Glu Ser Cys Lys  Asp Leu Thr 
        995                 1000                 1005             


Thr Ala  Glu Lys Leu Lys Arg  Glu Thr Pro Trp Lys  Ile Thr Asp 
    1010                 1015                 1020             


Ala Glu  Leu Glu Ala Val Lys  Glu Lys Ser Tyr Arg  Gln Val Arg 
    1025                 1030                 1035             


Leu Asn  Glu Leu Leu Gln Glu  His Ser Arg Ala Ala  Asn Leu Ile 
    1040                 1045                 1050             


Val Leu  Ser Leu Pro Val Ala  Arg Lys Gly Ser Ile  Ser Asp Leu 
    1055                 1060                 1065             


Leu Tyr  Met Ala Trp Leu Glu  Ile Leu Thr Lys Asn  Leu Pro Pro 
    1070                 1075                 1080             


Val Leu  Leu Val Arg Gly Asn  His Lys Asn Val Leu  Thr Phe Tyr 
    1085                 1090                 1095             


Ser 
    


<210>  1361
<211>  1874
<212>  DNA
<213>  Homosapiens

<400>  1361
gttttggcgc gctccctgcg gcgacgctca tcgtgcgctc tcctcttccc ccggtggtct     60

cctcgctcgc cttctggctc tgccatgccc tgctctgaag agacacccgc catttcaccc    120

agtaagcggg cccggcctgc ggaggtgggc ggcatgcagc tccgctttgc ccggctctcc    180

gagcacgcca cggcccccac ccggggctcc gcgcgcgccg cgggctacga cctgtacagt    240

gcctatgatt acacaatacc acctatggag aaagctgttg tgaaaacgga cattcagata    300

gcgctccctt ctgggtgtta tggaagagtg gctccacggt caggcttggc tgcaaaacac    360

tttattgatg taggagctgg tgtcatagat gaagattata gaggaaatgt tggtgttgta    420

ctgtttaatt ttggcaaaga aaagtttgaa gtcaaaaaag gtgatcgaat tgcacagctc    480

atttgcgaac ggatttttta tccagaaata gaagaagttc aagccttgga tgacaccgaa    540

aggggttcag gaggttttgg ttccactgga aagaattaaa atttatgcca agaacagaaa    600

acaagaagtc ataccttttt cttaaaaaaa aaaaaaaagt ttttgcttca agtgttttgg    660

tgttttgcac ttctgtaaac ttactagctt taccttctaa aagtactgca ttttttactt    720

ttttttatga tcaaggaaaa gatcattaaa aaaaaacaca aagaagtttt tctttgtgtt    780

tggatcaaaa agaaactttg tttttccgca attgaaggtt gtatgtaaat ctgctttgtg    840

gtgacctgat gtaaacagtg tcttcttaaa atcaaatgta aatcaattac agattaaaaa    900

aaaaagcctg tatttaactc atatgatctc ccttcagcaa cttattttgc tttaattgct    960

ttaaatctta agcaatattt tttattcagt aaacaaattc tttcacaagg tacaaaatct   1020

tgcataagct gaactaaaat aaaaatgaaa aggagagatt aaaggtattc cttgttcttc   1080

ccttctcttc actagtctaa aaacttcttt ttaatcttaa gattctttgt gatgagggtg   1140

agaaaaagaa tcctcagttt atttttccac tattaatctt tcttttgata aatcctctat   1200

tgactgggta gaggtatgtt tgtgaaagac atgtaacttg gggatttgtt actttaggtt   1260

tgttcccttg aatttcatct catcaggcaa attgtactag ttgtagttac gagttttccc   1320

tcagtgaagt agcaataggc tgtaatcaag aaaatatgcc atttatagag ataagataaa   1380

tgaaataata cttcagccac caggtttttc tgtctcacat acataagcag catttcattg   1440

cagatatggg actgattctg tggcttacct tgattaacat cttttggaag ttttgctagt   1500

gtgctttcct ttctttacta tgtttctcag attcctttgt atcagggttt tgggtgtcac   1560

ttaggttttg tccatcagat tctgtgagac accaggcatc gttttgagga tgtgggttat   1620

acacatggag tgcttctgga actatcagcc cacttgacca cccagtttgt ggaagcacag   1680

gcaagagtgt tcttttctgg tgattctcca ggccatttaa taccctgcaa tgtaattgtc   1740

cctctgtggc tcacatttca ttagtgagcc atgaaatcaa ctcagtggga catagccagc   1800

atttttgcat accaggttgg gctataaaat atttctgttg tcaataaatt ttaaatgttt   1860

tcctgctaaa ctaa                                                     1874


<210>  1362
<211>  164
<212>  PRT
<213>  Homosapiens

<400>  1362

Met Pro Cys Ser Glu Glu Thr Pro Ala Ile Ser Pro Ser Lys Arg Ala 
1               5                   10                  15      


Arg Pro Ala Glu Val Gly Gly Met Gln Leu Arg Phe Ala Arg Leu Ser 
            20                  25                  30          


Glu His Ala Thr Ala Pro Thr Arg Gly Ser Ala Arg Ala Ala Gly Tyr 
        35                  40                  45              


Asp Leu Tyr Ser Ala Tyr Asp Tyr Thr Ile Pro Pro Met Glu Lys Ala 
    50                  55                  60                  


Val Val Lys Thr Asp Ile Gln Ile Ala Leu Pro Ser Gly Cys Tyr Gly 
65                  70                  75                  80  


Arg Val Ala Pro Arg Ser Gly Leu Ala Ala Lys His Phe Ile Asp Val 
                85                  90                  95      


Gly Ala Gly Val Ile Asp Glu Asp Tyr Arg Gly Asn Val Gly Val Val 
            100                 105                 110         


Leu Phe Asn Phe Gly Lys Glu Lys Phe Glu Val Lys Lys Gly Asp Arg 
        115                 120                 125             


Ile Ala Gln Leu Ile Cys Glu Arg Ile Phe Tyr Pro Glu Ile Glu Glu 
    130                 135                 140                 


Val Gln Ala Leu Asp Asp Thr Glu Arg Gly Ser Gly Gly Phe Gly Ser 
145                 150                 155                 160 


Thr Gly Lys Asn 
                


<210>  1363
<211>  2146
<212>  DNA
<213>  Homosapiens

<400>  1363
gtcatgttcc caggacgggc gcgtcttcag ggtggaagcc tggcgcacgt ccggaggtgc     60

cgaggaccca accagcccaa actctggggg aaatgactcc cctctgccct cgccccgcgc    120

tctgctacca tttccttacg tctctgcttc gctcagcgat gcaaaacgcg cgaggcgcac    180

ggcagagggc cgaagccgcg gtactctccg ggccaggccc gcccctcggc cgcgccgcgc    240

agcacgggat tccccggccg ctgtccagcg ctggccgcct gagccaaggc tgccgcggag    300

ccagtacagt cggggccgct ggctggaagg gcgagcttcc taaggcgggg ggaagcccgg    360

cgccggggcc ggagacaccc gccatttcac ccagtaagcg ggcccggcct gcggaggtgg    420

gcggcatgca gctccgcttt gcccggctct ccgagcacgc cacggccccc acccggggct    480

ccgcgcgcgc cgcgggctac gacctgtaca gtgcctatga ttacacaata ccacctatgg    540

agaaagctgt tgtgaaaacg gacattcaga tagcgctccc ttctgggtgt tatggaagag    600

tggctccacg gtcaggcttg gctgcaaaac actttattga tgtaggagct ggtgtcatag    660

atgaagatta tagaggaaat gttggtgttg tactgtttaa ttttggcaaa gaaaagtttg    720

aagtcaaaaa aggtgatcga attgcacagc tcatttgcga acggattttt tatccagaaa    780

tagaagaagt tcaagccttg gatgacaccg aaaggggttc aggaggtttt ggttccactg    840

gaaagaatta aaatttatgc caagaacaga aaacaagaag tcataccttt ttcttaaaaa    900

aaaaaaaaaa gtttttgctt caagtgtttt ggtgttttgc acttctgtaa acttactagc    960

tttaccttct aaaagtactg cattttttac ttttttttat gatcaaggaa aagatcatta   1020

aaaaaaaaca caaagaagtt tttctttgtg tttggatcaa aaagaaactt tgtttttccg   1080

caattgaagg ttgtatgtaa atctgctttg tggtgacctg atgtaaacag tgtcttctta   1140

aaatcaaatg taaatcaatt acagattaaa aaaaaaagcc tgtatttaac tcatatgatc   1200

tcccttcagc aacttatttt gctttaattg ctttaaatct taagcaatat tttttattca   1260

gtaaacaaat tctttcacaa ggtacaaaat cttgcataag ctgaactaaa ataaaaatga   1320

aaaggagaga ttaaaggtat tccttgttct tcccttctct tcactagtct aaaaacttct   1380

ttttaatctt aagattcttt gtgatgaggg tgagaaaaag aatcctcagt ttatttttcc   1440

actattaatc tttcttttga taaatcctct attgactggg tagaggtatg tttgtgaaag   1500

acatgtaact tggggatttg ttactttagg tttgttccct tgaatttcat ctcatcaggc   1560

aaattgtact agttgtagtt acgagttttc cctcagtgaa gtagcaatag gctgtaatca   1620

agaaaatatg ccatttatag agataagata aatgaaataa tacttcagcc accaggtttt   1680

tctgtctcac atacataagc agcatttcat tgcagatatg ggactgattc tgtggcttac   1740

cttgattaac atcttttgga agttttgcta gtgtgctttc ctttctttac tatgtttctc   1800

agattccttt gtatcagggt tttgggtgtc acttaggttt tgtccatcag attctgtgag   1860

acaccaggca tcgttttgag gatgtgggtt atacacatgg agtgcttctg gaactatcag   1920

cccacttgac cacccagttt gtggaagcac aggcaagagt gttcttttct ggtgattctc   1980

caggccattt aataccctgc aatgtaattg tccctctgtg gctcacattt cattagtgag   2040

ccatgaaatc aactcagtgg gacatagcca gcatttttgc ataccaggtt gggctataaa   2100

atatttctgt tgtcaataaa ttttaaatgt tttcctgcta aactaa                  2146


<210>  1364
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  1364

Met Thr Pro Leu Cys Pro Arg Pro Ala Leu Cys Tyr His Phe Leu Thr 
1               5                   10                  15      


Ser Leu Leu Arg Ser Ala Met Gln Asn Ala Arg Gly Ala Arg Gln Arg 
            20                  25                  30          


Ala Glu Ala Ala Val Leu Ser Gly Pro Gly Pro Pro Leu Gly Arg Ala 
        35                  40                  45              


Ala Gln His Gly Ile Pro Arg Pro Leu Ser Ser Ala Gly Arg Leu Ser 
    50                  55                  60                  


Gln Gly Cys Arg Gly Ala Ser Thr Val Gly Ala Ala Gly Trp Lys Gly 
65                  70                  75                  80  


Glu Leu Pro Lys Ala Gly Gly Ser Pro Ala Pro Gly Pro Glu Thr Pro 
                85                  90                  95      


Ala Ile Ser Pro Ser Lys Arg Ala Arg Pro Ala Glu Val Gly Gly Met 
            100                 105                 110         


Gln Leu Arg Phe Ala Arg Leu Ser Glu His Ala Thr Ala Pro Thr Arg 
        115                 120                 125             


Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp Tyr 
    130                 135                 140                 


Thr Ile Pro Pro Met Glu Lys Ala Val Val Lys Thr Asp Ile Gln Ile 
145                 150                 155                 160 


Ala Leu Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly Leu 
                165                 170                 175     


Ala Ala Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu Asp 
            180                 185                 190         


Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu Lys 
        195                 200                 205             


Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu Arg 
    210                 215                 220                 


Ile Phe Tyr Pro Glu Ile Glu Glu Val Gln Ala Leu Asp Asp Thr Glu 
225                 230                 235                 240 


Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn 
                245                 250         


<210>  1365
<211>  1830
<212>  DNA
<213>  Homosapiens

<400>  1365
gtcatgttcc caggacgggc gcgtcttcag ggtggaagcc tggcgcacgt ccggagagac     60

acccgccatt tcacccagta agcgggcccg gcctgcggag gtgggcggca tgcagctccg    120

ctttgcccgg ctctccgagc acgccacggc ccccacccgg ggctccgcgc gcgccgcggg    180

ctacgacctg tacagtgcct atgattacac aataccacct atggagaaag ctgttgtgaa    240

aacggacatt cagatagcgc tcccttctgg gtgttatgga agagtggctc cacggtcagg    300

cttggctgca aaacacttta ttgatgtagg agctggtgtc atagatgaag attatagagg    360

aaatgttggt gttgtactgt ttaattttgg caaagaaaag tttgaagtca aaaaaggtga    420

tcgaattgca cagctcattt gcgaacggat tttttatcca gaaatagaag aagttcaagc    480

cttggatgac accgaaaggg gttcaggagg ttttggttcc actggaaaga attaaaattt    540

atgccaagaa cagaaaacaa gaagtcatac ctttttctta aaaaaaaaaa aaaagttttt    600

gcttcaagtg ttttggtgtt ttgcacttct gtaaacttac tagctttacc ttctaaaagt    660

actgcatttt ttactttttt ttatgatcaa ggaaaagatc attaaaaaaa aacacaaaga    720

agtttttctt tgtgtttgga tcaaaaagaa actttgtttt tccgcaattg aaggttgtat    780

gtaaatctgc tttgtggtga cctgatgtaa acagtgtctt cttaaaatca aatgtaaatc    840

aattacagat taaaaaaaaa agcctgtatt taactcatat gatctccctt cagcaactta    900

ttttgcttta attgctttaa atcttaagca atatttttta ttcagtaaac aaattctttc    960

acaaggtaca aaatcttgca taagctgaac taaaataaaa atgaaaagga gagattaaag   1020

gtattccttg ttcttccctt ctcttcacta gtctaaaaac ttctttttaa tcttaagatt   1080

ctttgtgatg agggtgagaa aaagaatcct cagtttattt ttccactatt aatctttctt   1140

ttgataaatc ctctattgac tgggtagagg tatgtttgtg aaagacatgt aacttgggga   1200

tttgttactt taggtttgtt cccttgaatt tcatctcatc aggcaaattg tactagttgt   1260

agttacgagt tttccctcag tgaagtagca ataggctgta atcaagaaaa tatgccattt   1320

atagagataa gataaatgaa ataatacttc agccaccagg tttttctgtc tcacatacat   1380

aagcagcatt tcattgcaga tatgggactg attctgtggc ttaccttgat taacatcttt   1440

tggaagtttt gctagtgtgc tttcctttct ttactatgtt tctcagattc ctttgtatca   1500

gggttttggg tgtcacttag gttttgtcca tcagattctg tgagacacca ggcatcgttt   1560

tgaggatgtg ggttatacac atggagtgct tctggaacta tcagcccact tgaccaccca   1620

gtttgtggaa gcacaggcaa gagtgttctt ttctggtgat tctccaggcc atttaatacc   1680

ctgcaatgta attgtccctc tgtggctcac atttcattag tgagccatga aatcaactca   1740

gtgggacata gccagcattt ttgcatacca ggttgggcta taaaatattt ctgttgtcaa   1800

taaattttaa atgttttcct gctaaactaa                                    1830


<210>  1366
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  1366

Met Gln Leu Arg Phe Ala Arg Leu Ser Glu His Ala Thr Ala Pro Thr 
1               5                   10                  15      


Arg Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp 
            20                  25                  30          


Tyr Thr Ile Pro Pro Met Glu Lys Ala Val Val Lys Thr Asp Ile Gln 
        35                  40                  45              


Ile Ala Leu Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly 
    50                  55                  60                  


Leu Ala Ala Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu 
65                  70                  75                  80  


Asp Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu 
                85                  90                  95      


Lys Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu 
            100                 105                 110         


Arg Ile Phe Tyr Pro Glu Ile Glu Glu Val Gln Ala Leu Asp Asp Thr 
        115                 120                 125             


Glu Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn 
    130                 135                 140     


<210>  1367
<211>  4068
<212>  DNA
<213>  Homosapiens

<400>  1367
gccagcatct tgtagttgag ctctctttat cctatagtgg gggggccctc ctgggtctgg     60

agctcagccc ccatcctttc attctccctt gcttccttca ctcatgcact cattcgtaaa    120

acatttgtgc agccggtacg tggtggagcg tcagggcacg atggcccttc ctgccctcct    180

gacccgcctc cttcctctcc gcaggctttt tgtcctgggc atcggcttct tcactctctg    240

cttcctgatg acgtctctgg gaggccagtt ctcggcccgg cgcctggggg actcgccatt    300

caccatccgc acagaagtga tggggggccc cgagtcccgc ggcgtcctgc gcaagatgag    360

cgacctgctg gagctgatgg tgaagcgcat ggacgcactg gccaggctgg agaacagcag    420

tgagctgcac cgggccggcg gcgacctgca ctttcccgca gacaggatgc cccctggggc    480

cggcctcatg gagcggatcc aggctattgc ccagaacgtc tccgacatcg ctgtgaaggt    540

ggaccagatc ctgcgccaca gtctgctcct gcacagcaag gtgtcagaag gccggcggga    600

ccagtgtgag gcacccagtg accccaagtt ccctgactgc tcagggaagg tggagtggat    660

gcgtgcccgc tggacctctg acccctgcta cgccttcttt ggggtggacg gcaccgagtg    720

ctccttcctc atctacctca gtgaggtcga gtggttctgc cccccgctgc cctggaggaa    780

ccagacggct gcccagaggg cacccaagcc cctccccaaa gtccaggcag ttttccgaag    840

caacctgtcc caccttctgg acctgatggg cagcgggaag gagtccctga tcttcatgaa    900

gaagcggacc aagaggctca cagcccagtg ggcgctggct gcccagcgcc tggcacagaa    960

gctgggggcc acccagaggg accagaagca gatcctggtc cacatcggct tcctgacgga   1020

ggagtccggg gacgtgttca gccctcgggt cctgaagggc gggcccctag gggagatggt   1080

gcagtgggcg gacattctga ctgcactcta tgtcctgggc catggcctgc gggtcacagt   1140

ctccctgaag gagctgcaga gtaacttagg ggtaccgcca ggccggggaa gctgcccgct   1200

caccatgccc ctgcccttcg acctcatcta caccgactac cacggcctgc agcagatgaa   1260

gcggcacatg ggactctcct tcaagaagta ccggtgccga atcagggtca tcgacacctt   1320

cgggacggaa cctgcgtaca accacgagga gtacgccacg ctgcacggct accggaccaa   1380

ctggggctac tggaacctca accccaagca gttcatgacc atgtttcctc atacccccga   1440

caactccttc atgggcttcg tgtccgagga gctcaacgag acggagaagc ggctcatcaa   1500

aggcggcaag gccagcaaca tggccgtggt gtacggcaag gaggcgagca tctggaaggg   1560

gaaggagaag ttcctgggca tcctgaacaa atacatggag atccatggca ccgtgtacta   1620

cgagagccag cggccccccg aggtgccagc ctttgtgaag aaccacggcc tcttaccgca   1680

gcctgagttt cagcagctgc tgcgcaaggc caaactcttc atcgggtttg gcttccccta   1740

cgagggcccc gcccccctgg aggccatcgc caatggttgc atcttcctgc agtcccgctt   1800

cagcccgccc cacagctccc tcaaccacga gttcttccga ggcaagccca cctccagaga   1860

ggtgttctcc cagcatccct acgcggagaa cttcatcggc aagccccacg tgtggacagt   1920

cgactacaac aactcagagg agtttgaagc agccatcaag gccattatga gaactcaggt   1980

agacccctac ctaccctacg agtacacctg cgaggggatg ctggagcgga tccacgccta   2040

catccagcac caggacttct gcagagctcc agaccctgcc ctaccagagg cccacgcccc   2100

gcagagcccc tttgtcctgg cccccaatgc cacccacctc gagtgggctc ggaacaccag   2160

cttggctcct ggggcctggc cccccgcgca cgccctgcgg gcctggctgg ccgtgcctgg   2220

gagggcctgc accgacacct gcctggacca cgggctaatc tgtgagccct ccttcttccc   2280

cttcctgaac agccaggacg ccttcctcaa gctgcaggtg ccctgtgaca gcaccgagtc   2340

ggagatgaac cacctgtacc cggcgttcgc ccagcctggc caggagtgct acctgcagaa   2400

ggagcctctg ctcttcagct gcgccggctc caacaccaag taccgccggc tctgcccctg   2460

ccgcgacttc cgcaagggcc aggtggcctt gtgccagggc tgtctgtgaa tccgcctctg   2520

ccgccctgcc tggcacccac gctggctctc tcctgccgcg ggagaaagca ccagcaggtt   2580

ctgagccctg gctgcttgtc ctcctcgcaa cccccccagg ccggagcttc cttccttagc   2640

cgggaagctg gcagaggaga gccgtgcccg ggaataggag gaggcagcat gccgagcccc   2700

tgggacctcc caggcaggct ccggttctct cctggggact cacagaagca tcgtggccaa   2760

gcaggtgtcg gactgctcag agtccgcatg gcccaggagc aggtggtcgg aggcccctgg   2820

ctttgtgcaa ggccggatct gggccaggtg gcgaaagggg cccagtcgtt cttgggccca   2880

ggatggggcc tctagacttg caagggagag gaacagggac caggctgccc cacggtccct   2940

gaagggtcca aggaggggcc ctccccatgg ccctggagag tgggcctggg tggtacctgc   3000

tccaggcagg gaaactgggg gctcgccctt ctcctgtgag gggagccagg cacacagggc   3060

ccattggtgt ttgggatgtg gacagagggg cagggggctg ggagaaggct aagccgaggg   3120

gtcctgtttg tgcctcccct tagtcccttc cctcccgatt tcccgattcc cccaccctcc   3180

ctctacactt gaggaccaca gttgggggtg tagggaccac ccagaccctg gttgaattgt   3240

ttctctctcc tgcttgttcc aacccttttc actctgggct tctcccaaaa cccatcctgg   3300

catgacctgc aactccaggt ggtggatttg ttccaaagcc tcaatcccta ccccctccaa   3360

ggggcaggtt tccagtccag cctcagagat caggctctgg gacccctgcc tggggggtgg   3420

ccttcatgca ctagccactt ccgcaggtgc tgactcccgc actccctggc attttttgca   3480

gacaagggct tgggatggac cctcagcccc atggtacgcc ctgcccagtt tccagttgcc   3540

ctgtccactt accctaggta gccccccacc ccatcagtgc cgagtccttg tccctacctc   3600

cagcttcctc cagcctcaaa ccgcctctgg atctagctgt ccttctccga gtggcacgcc   3660

tgccccagga tgcccccttt ccctcccccc catgcccaga gccccgcctg cctcagcggg   3720

tcaggccttc agaacactgc cacccaccca gttttataat cccgctccct ctccaggcaa   3780

ccccacccac cagcctaggc ctgctcctcc acccttcccg ggaggcagcc ccgggatgct   3840

gagagttggt ggaggggcca ggctggacgc ttcctgtggg agtcccctcc agacctggct   3900

ggcccctgca gccacagaaa ccacgatggc aaaaaatctc attggttctc aaggactaac   3960

ctgtggggga aagcaataga gacactcttt ttctctcttt tttttaaaga tttatttctt   4020

gaaataataa atattttatt gggatgtgag gtgcagaaga aaaaaaaa                4068


<210>  1368
<211>  801
<212>  PRT
<213>  Homosapiens

<400>  1368

Met His Ser Phe Val Lys His Leu Cys Ser Arg Tyr Val Val Glu Arg 
1               5                   10                  15      


Gln Gly Thr Met Ala Leu Pro Ala Leu Leu Thr Arg Leu Leu Pro Leu 
            20                  25                  30          


Arg Arg Leu Phe Val Leu Gly Ile Gly Phe Phe Thr Leu Cys Phe Leu 
        35                  40                  45              


Met Thr Ser Leu Gly Gly Gln Phe Ser Ala Arg Arg Leu Gly Asp Ser 
    50                  55                  60                  


Pro Phe Thr Ile Arg Thr Glu Val Met Gly Gly Pro Glu Ser Arg Gly 
65                  70                  75                  80  


Val Leu Arg Lys Met Ser Asp Leu Leu Glu Leu Met Val Lys Arg Met 
                85                  90                  95      


Asp Ala Leu Ala Arg Leu Glu Asn Ser Ser Glu Leu His Arg Ala Gly 
            100                 105                 110         


Gly Asp Leu His Phe Pro Ala Asp Arg Met Pro Pro Gly Ala Gly Leu 
        115                 120                 125             


Met Glu Arg Ile Gln Ala Ile Ala Gln Asn Val Ser Asp Ile Ala Val 
    130                 135                 140                 


Lys Val Asp Gln Ile Leu Arg His Ser Leu Leu Leu His Ser Lys Val 
145                 150                 155                 160 


Ser Glu Gly Arg Arg Asp Gln Cys Glu Ala Pro Ser Asp Pro Lys Phe 
                165                 170                 175     


Pro Asp Cys Ser Gly Lys Val Glu Trp Met Arg Ala Arg Trp Thr Ser 
            180                 185                 190         


Asp Pro Cys Tyr Ala Phe Phe Gly Val Asp Gly Thr Glu Cys Ser Phe 
        195                 200                 205             


Leu Ile Tyr Leu Ser Glu Val Glu Trp Phe Cys Pro Pro Leu Pro Trp 
    210                 215                 220                 


Arg Asn Gln Thr Ala Ala Gln Arg Ala Pro Lys Pro Leu Pro Lys Val 
225                 230                 235                 240 


Gln Ala Val Phe Arg Ser Asn Leu Ser His Leu Leu Asp Leu Met Gly 
                245                 250                 255     


Ser Gly Lys Glu Ser Leu Ile Phe Met Lys Lys Arg Thr Lys Arg Leu 
            260                 265                 270         


Thr Ala Gln Trp Ala Leu Ala Ala Gln Arg Leu Ala Gln Lys Leu Gly 
        275                 280                 285             


Ala Thr Gln Arg Asp Gln Lys Gln Ile Leu Val His Ile Gly Phe Leu 
    290                 295                 300                 


Thr Glu Glu Ser Gly Asp Val Phe Ser Pro Arg Val Leu Lys Gly Gly 
305                 310                 315                 320 


Pro Leu Gly Glu Met Val Gln Trp Ala Asp Ile Leu Thr Ala Leu Tyr 
                325                 330                 335     


Val Leu Gly His Gly Leu Arg Val Thr Val Ser Leu Lys Glu Leu Gln 
            340                 345                 350         


Ser Asn Leu Gly Val Pro Pro Gly Arg Gly Ser Cys Pro Leu Thr Met 
        355                 360                 365             


Pro Leu Pro Phe Asp Leu Ile Tyr Thr Asp Tyr His Gly Leu Gln Gln 
    370                 375                 380                 


Met Lys Arg His Met Gly Leu Ser Phe Lys Lys Tyr Arg Cys Arg Ile 
385                 390                 395                 400 


Arg Val Ile Asp Thr Phe Gly Thr Glu Pro Ala Tyr Asn His Glu Glu 
                405                 410                 415     


Tyr Ala Thr Leu His Gly Tyr Arg Thr Asn Trp Gly Tyr Trp Asn Leu 
            420                 425                 430         


Asn Pro Lys Gln Phe Met Thr Met Phe Pro His Thr Pro Asp Asn Ser 
        435                 440                 445             


Phe Met Gly Phe Val Ser Glu Glu Leu Asn Glu Thr Glu Lys Arg Leu 
    450                 455                 460                 


Ile Lys Gly Gly Lys Ala Ser Asn Met Ala Val Val Tyr Gly Lys Glu 
465                 470                 475                 480 


Ala Ser Ile Trp Lys Gly Lys Glu Lys Phe Leu Gly Ile Leu Asn Lys 
                485                 490                 495     


Tyr Met Glu Ile His Gly Thr Val Tyr Tyr Glu Ser Gln Arg Pro Pro 
            500                 505                 510         


Glu Val Pro Ala Phe Val Lys Asn His Gly Leu Leu Pro Gln Pro Glu 
        515                 520                 525             


Phe Gln Gln Leu Leu Arg Lys Ala Lys Leu Phe Ile Gly Phe Gly Phe 
    530                 535                 540                 


Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile Ala Asn Gly Cys Ile 
545                 550                 555                 560 


Phe Leu Gln Ser Arg Phe Ser Pro Pro His Ser Ser Leu Asn His Glu 
                565                 570                 575     


Phe Phe Arg Gly Lys Pro Thr Ser Arg Glu Val Phe Ser Gln His Pro 
            580                 585                 590         


Tyr Ala Glu Asn Phe Ile Gly Lys Pro His Val Trp Thr Val Asp Tyr 
        595                 600                 605             


Asn Asn Ser Glu Glu Phe Glu Ala Ala Ile Lys Ala Ile Met Arg Thr 
    610                 615                 620                 


Gln Val Asp Pro Tyr Leu Pro Tyr Glu Tyr Thr Cys Glu Gly Met Leu 
625                 630                 635                 640 


Glu Arg Ile His Ala Tyr Ile Gln His Gln Asp Phe Cys Arg Ala Pro 
                645                 650                 655     


Asp Pro Ala Leu Pro Glu Ala His Ala Pro Gln Ser Pro Phe Val Leu 
            660                 665                 670         


Ala Pro Asn Ala Thr His Leu Glu Trp Ala Arg Asn Thr Ser Leu Ala 
        675                 680                 685             


Pro Gly Ala Trp Pro Pro Ala His Ala Leu Arg Ala Trp Leu Ala Val 
    690                 695                 700                 


Pro Gly Arg Ala Cys Thr Asp Thr Cys Leu Asp His Gly Leu Ile Cys 
705                 710                 715                 720 


Glu Pro Ser Phe Phe Pro Phe Leu Asn Ser Gln Asp Ala Phe Leu Lys 
                725                 730                 735     


Leu Gln Val Pro Cys Asp Ser Thr Glu Ser Glu Met Asn His Leu Tyr 
            740                 745                 750         


Pro Ala Phe Ala Gln Pro Gly Gln Glu Cys Tyr Leu Gln Lys Glu Pro 
        755                 760                 765             


Leu Leu Phe Ser Cys Ala Gly Ser Asn Thr Lys Tyr Arg Arg Leu Cys 
    770                 775                 780                 


Pro Cys Arg Asp Phe Arg Lys Gly Gln Val Ala Leu Cys Gln Gly Cys 
785                 790                 795                 800 


Leu 
    


<210>  1369
<211>  4246
<212>  DNA
<213>  Homosapiens

<400>  1369
gcgagcccga gcaggcagac gcgcggccgg cggtctgggg gcgcgccgcc tcccggtccc     60

caaaatgtga agcggggagg gcggagacgc agagacggcc cggccgggcg ccctcgccgc    120

cctccggcag ccgcgccgct ccctccgctg cacgcccagg cctgagcagc gaggccaccg    180

ggccgcgcgc tcccagcttc gctcggacgc ggcttcggcc cgcagagggt tcgtggcccg    240

gacgcggcga gagctgggcc caggacggtg cgtccggcct cgcccgcggc tgctcgcacc    300

aacaagtttg aacaatgatc accgtcaacc ccgatgggaa gataatggtc agaagatgcc    360

tggtcaccct gagacccttt cggctttttg tcctgggcat cggcttcttc actctctgct    420

tcctgatgac gtctctggga ggccagttct cggcccggcg cctgggggac tcgccattca    480

ccatccgcac agaagtgatg gggggccccg agtcccgcgg cgtcctgcgc aagatgagcg    540

acctgctgga gctgatggtg aagcgcatgg acgcactggc caggctggag aacagcagtg    600

agctgcaccg ggccggcggc gacctgcact ttcccgcaga caggatgccc cctggggccg    660

gcctcatgga gcggatccag gctattgccc agaacgtctc cgacatcgct gtgaaggtgg    720

accagatcct gcgccacagt ctgctcctgc acagcaaggt gtcagaaggc cggcgggacc    780

agtgtgaggc acccagtgac cccaagttcc ctgactgctc agggaaggtg gagtggatgc    840

gtgcccgctg gacctctgac ccctgctacg ccttctttgg ggtggacggc accgagtgct    900

ccttcctcat ctacctcagt gaggtcgagt ggttctgccc cccgctgccc tggaggaacc    960

agacggctgc ccagagggca cccaagcccc tccccaaagt ccaggcagtt ttccgaagca   1020

acctgtccca ccttctggac ctgatgggca gcgggaagga gtccctgatc ttcatgaaga   1080

agcggaccaa gaggctcaca gcccagtggg cgctggctgc ccagcgcctg gcacagaagc   1140

tgggggccac ccagagggac cagaagcaga tcctggtcca catcggcttc ctgacggagg   1200

agtccgggga cgtgttcagc cctcgggtcc tgaagggcgg gcccctaggg gagatggtgc   1260

agtgggcgga cattctgact gcactctatg tcctgggcca tggcctgcgg gtcacagtct   1320

ccctgaagga gctgcagagt aacttagggg taccgccagg ccggggaagc tgcccgctca   1380

ccatgcccct gcccttcgac ctcatctaca ccgactacca cggcctgcag cagatgaagc   1440

ggcacatggg actctccttc aagaagtacc ggtgccgaat cagggtcatc gacaccttcg   1500

ggacggaacc tgcgtacaac cacgaggagt acgccacgct gcacggctac cggaccaact   1560

ggggctactg gaacctcaac cccaagcagt tcatgaccat gtttcctcat acccccgaca   1620

actccttcat gggcttcgtg tccgaggagc tcaacgagac ggagaagcgg ctcatcaaag   1680

gcggcaaggc cagcaacatg gccgtggtgt acggcaagga ggcgagcatc tggaagggga   1740

aggagaagtt cctgggcatc ctgaacaaat acatggagat ccatggcacc gtgtactacg   1800

agagccagcg gccccccgag gtgccagcct ttgtgaagaa ccacggcctc ttaccgcagc   1860

ctgagtttca gcagctgctg cgcaaggcca aactcttcat cgggtttggc ttcccctacg   1920

agggccccgc ccccctggag gccatcgcca atggttgcat cttcctgcag tcccgcttca   1980

gcccgcccca cagctccctc aaccacgagt tcttccgagg caagcccacc tccagagagg   2040

tgttctccca gcatccctac gcggagaact tcatcggcaa gccccacgtg tggacagtcg   2100

actacaacaa ctcagaggag tttgaagcag ccatcaaggc cattatgaga actcaggtag   2160

acccctacct accctacgag tacacctgcg aggggatgct ggagcggatc cacgcctaca   2220

tccagcacca ggacttctgc agagctccag accctgccct accagaggcc cacgccccgc   2280

agagcccctt tgtcctggcc cccaatgcca cccacctcga gtgggctcgg aacaccagct   2340

tggctcctgg ggcctggccc cccgcgcacg ccctgcgggc ctggctggcc gtgcctggga   2400

gggcctgcac cgacacctgc ctggaccacg ggctaatctg tgagccctcc ttcttcccct   2460

tcctgaacag ccaggacgcc ttcctcaagc tgcaggtgcc ctgtgacagc accgagtcgg   2520

agatgaacca cctgtacccg gcgttcgccc agcctggcca ggagtgctac ctgcagaagg   2580

agcctctgct cttcagctgc gccggctcca acaccaagta ccgccggctc tgcccctgcc   2640

gcgacttccg caagggccag gtggccttgt gccagggctg tctgtgaatc cgcctctgcc   2700

gccctgcctg gcacccacgc tggctctctc ctgccgcggg agaaagcacc agcaggttct   2760

gagccctggc tgcttgtcct cctcgcaacc cccccaggcc ggagcttcct tccttagccg   2820

ggaagctggc agaggagagc cgtgcccggg aataggagga ggcagcatgc cgagcccctg   2880

ggacctccca ggcaggctcc ggttctctcc tggggactca cagaagcatc gtggccaagc   2940

aggtgtcgga ctgctcagag tccgcatggc ccaggagcag gtggtcggag gcccctggct   3000

ttgtgcaagg ccggatctgg gccaggtggc gaaaggggcc cagtcgttct tgggcccagg   3060

atggggcctc tagacttgca agggagagga acagggacca ggctgcccca cggtccctga   3120

agggtccaag gaggggccct ccccatggcc ctggagagtg ggcctgggtg gtacctgctc   3180

caggcaggga aactgggggc tcgcccttct cctgtgaggg gagccaggca cacagggccc   3240

attggtgttt gggatgtgga cagaggggca gggggctggg agaaggctaa gccgaggggt   3300

cctgtttgtg cctcccctta gtcccttccc tcccgatttc ccgattcccc caccctccct   3360

ctacacttga ggaccacagt tgggggtgta gggaccaccc agaccctggt tgaattgttt   3420

ctctctcctg cttgttccaa cccttttcac tctgggcttc tcccaaaacc catcctggca   3480

tgacctgcaa ctccaggtgg tggatttgtt ccaaagcctc aatccctacc ccctccaagg   3540

ggcaggtttc cagtccagcc tcagagatca ggctctggga cccctgcctg gggggtggcc   3600

ttcatgcact agccacttcc gcaggtgctg actcccgcac tccctggcat tttttgcaga   3660

caagggcttg ggatggaccc tcagccccat ggtacgccct gcccagtttc cagttgccct   3720

gtccacttac cctaggtagc cccccacccc atcagtgccg agtccttgtc cctacctcca   3780

gcttcctcca gcctcaaacc gcctctggat ctagctgtcc ttctccgagt ggcacgcctg   3840

ccccaggatg ccccctttcc ctccccccca tgcccagagc cccgcctgcc tcagcgggtc   3900

aggccttcag aacactgcca cccacccagt tttataatcc cgctccctct ccaggcaacc   3960

ccacccacca gcctaggcct gctcctccac ccttcccggg aggcagcccc gggatgctga   4020

gagttggtgg aggggccagg ctggacgctt cctgtgggag tcccctccag acctggctgg   4080

cccctgcagc cacagaaacc acgatggcaa aaaatctcat tggttctcaa ggactaacct   4140

gtgggggaaa gcaatagaga cactcttttt ctctcttttt tttaaagatt tatttcttga   4200

aataataaat attttattgg gatgtgaggt gcagaagaaa aaaaaa                  4246


<210>  1370
<211>  790
<212>  PRT
<213>  Homosapiens

<400>  1370

Met Ile Thr Val Asn Pro Asp Gly Lys Ile Met Val Arg Arg Cys Leu 
1               5                   10                  15      


Val Thr Leu Arg Pro Phe Arg Leu Phe Val Leu Gly Ile Gly Phe Phe 
            20                  25                  30          


Thr Leu Cys Phe Leu Met Thr Ser Leu Gly Gly Gln Phe Ser Ala Arg 
        35                  40                  45              


Arg Leu Gly Asp Ser Pro Phe Thr Ile Arg Thr Glu Val Met Gly Gly 
    50                  55                  60                  


Pro Glu Ser Arg Gly Val Leu Arg Lys Met Ser Asp Leu Leu Glu Leu 
65                  70                  75                  80  


Met Val Lys Arg Met Asp Ala Leu Ala Arg Leu Glu Asn Ser Ser Glu 
                85                  90                  95      


Leu His Arg Ala Gly Gly Asp Leu His Phe Pro Ala Asp Arg Met Pro 
            100                 105                 110         


Pro Gly Ala Gly Leu Met Glu Arg Ile Gln Ala Ile Ala Gln Asn Val 
        115                 120                 125             


Ser Asp Ile Ala Val Lys Val Asp Gln Ile Leu Arg His Ser Leu Leu 
    130                 135                 140                 


Leu His Ser Lys Val Ser Glu Gly Arg Arg Asp Gln Cys Glu Ala Pro 
145                 150                 155                 160 


Ser Asp Pro Lys Phe Pro Asp Cys Ser Gly Lys Val Glu Trp Met Arg 
                165                 170                 175     


Ala Arg Trp Thr Ser Asp Pro Cys Tyr Ala Phe Phe Gly Val Asp Gly 
            180                 185                 190         


Thr Glu Cys Ser Phe Leu Ile Tyr Leu Ser Glu Val Glu Trp Phe Cys 
        195                 200                 205             


Pro Pro Leu Pro Trp Arg Asn Gln Thr Ala Ala Gln Arg Ala Pro Lys 
    210                 215                 220                 


Pro Leu Pro Lys Val Gln Ala Val Phe Arg Ser Asn Leu Ser His Leu 
225                 230                 235                 240 


Leu Asp Leu Met Gly Ser Gly Lys Glu Ser Leu Ile Phe Met Lys Lys 
                245                 250                 255     


Arg Thr Lys Arg Leu Thr Ala Gln Trp Ala Leu Ala Ala Gln Arg Leu 
            260                 265                 270         


Ala Gln Lys Leu Gly Ala Thr Gln Arg Asp Gln Lys Gln Ile Leu Val 
        275                 280                 285             


His Ile Gly Phe Leu Thr Glu Glu Ser Gly Asp Val Phe Ser Pro Arg 
    290                 295                 300                 


Val Leu Lys Gly Gly Pro Leu Gly Glu Met Val Gln Trp Ala Asp Ile 
305                 310                 315                 320 


Leu Thr Ala Leu Tyr Val Leu Gly His Gly Leu Arg Val Thr Val Ser 
                325                 330                 335     


Leu Lys Glu Leu Gln Ser Asn Leu Gly Val Pro Pro Gly Arg Gly Ser 
            340                 345                 350         


Cys Pro Leu Thr Met Pro Leu Pro Phe Asp Leu Ile Tyr Thr Asp Tyr 
        355                 360                 365             


His Gly Leu Gln Gln Met Lys Arg His Met Gly Leu Ser Phe Lys Lys 
    370                 375                 380                 


Tyr Arg Cys Arg Ile Arg Val Ile Asp Thr Phe Gly Thr Glu Pro Ala 
385                 390                 395                 400 


Tyr Asn His Glu Glu Tyr Ala Thr Leu His Gly Tyr Arg Thr Asn Trp 
                405                 410                 415     


Gly Tyr Trp Asn Leu Asn Pro Lys Gln Phe Met Thr Met Phe Pro His 
            420                 425                 430         


Thr Pro Asp Asn Ser Phe Met Gly Phe Val Ser Glu Glu Leu Asn Glu 
        435                 440                 445             


Thr Glu Lys Arg Leu Ile Lys Gly Gly Lys Ala Ser Asn Met Ala Val 
    450                 455                 460                 


Val Tyr Gly Lys Glu Ala Ser Ile Trp Lys Gly Lys Glu Lys Phe Leu 
465                 470                 475                 480 


Gly Ile Leu Asn Lys Tyr Met Glu Ile His Gly Thr Val Tyr Tyr Glu 
                485                 490                 495     


Ser Gln Arg Pro Pro Glu Val Pro Ala Phe Val Lys Asn His Gly Leu 
            500                 505                 510         


Leu Pro Gln Pro Glu Phe Gln Gln Leu Leu Arg Lys Ala Lys Leu Phe 
        515                 520                 525             


Ile Gly Phe Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
    530                 535                 540                 


Ala Asn Gly Cys Ile Phe Leu Gln Ser Arg Phe Ser Pro Pro His Ser 
545                 550                 555                 560 


Ser Leu Asn His Glu Phe Phe Arg Gly Lys Pro Thr Ser Arg Glu Val 
                565                 570                 575     


Phe Ser Gln His Pro Tyr Ala Glu Asn Phe Ile Gly Lys Pro His Val 
            580                 585                 590         


Trp Thr Val Asp Tyr Asn Asn Ser Glu Glu Phe Glu Ala Ala Ile Lys 
        595                 600                 605             


Ala Ile Met Arg Thr Gln Val Asp Pro Tyr Leu Pro Tyr Glu Tyr Thr 
    610                 615                 620                 


Cys Glu Gly Met Leu Glu Arg Ile His Ala Tyr Ile Gln His Gln Asp 
625                 630                 635                 640 


Phe Cys Arg Ala Pro Asp Pro Ala Leu Pro Glu Ala His Ala Pro Gln 
                645                 650                 655     


Ser Pro Phe Val Leu Ala Pro Asn Ala Thr His Leu Glu Trp Ala Arg 
            660                 665                 670         


Asn Thr Ser Leu Ala Pro Gly Ala Trp Pro Pro Ala His Ala Leu Arg 
        675                 680                 685             


Ala Trp Leu Ala Val Pro Gly Arg Ala Cys Thr Asp Thr Cys Leu Asp 
    690                 695                 700                 


His Gly Leu Ile Cys Glu Pro Ser Phe Phe Pro Phe Leu Asn Ser Gln 
705                 710                 715                 720 


Asp Ala Phe Leu Lys Leu Gln Val Pro Cys Asp Ser Thr Glu Ser Glu 
                725                 730                 735     


Met Asn His Leu Tyr Pro Ala Phe Ala Gln Pro Gly Gln Glu Cys Tyr 
            740                 745                 750         


Leu Gln Lys Glu Pro Leu Leu Phe Ser Cys Ala Gly Ser Asn Thr Lys 
        755                 760                 765             


Tyr Arg Arg Leu Cys Pro Cys Arg Asp Phe Arg Lys Gly Gln Val Ala 
    770                 775                 780                 


Leu Cys Gln Gly Cys Leu 
785                 790 


<210>  1371
<211>  827
<212>  DNA
<213>  Homosapiens

<400>  1371
cgctcggccc cgccccgggc agctatttgg cacatttcaa ttagcgtaac gggtgcctgg     60

taaacagccg aggccggctg cgggcacctg caatccccga cccccgacgc cctccccgag    120

accctggaga cgcggctccg cccccaccgg taattaggag attttcaagg cctatgtccc    180

caaagcccag cccagctgga gagatcagcc ctgcggtcct gccgcgcact ccaccgccag    240

cctctcggga gtcaagggat ccgccttcag ggtgaattgg ggttccacca tgtcaccctc    300

atggagcttt cgttagcctt gtttgggata caaaggggta agtgtcccct cattttagag    360

aaagatcaag agccagtgaa caggatttcc cagccaggga catggagcag ggcacctgca    420

gatggtccac gtgctcttgg ctgatggcag cccacctccg ggaggggcct gtgcaccttt    480

ctcccaggag gagggaagga cccaatcatt atccagagtc aacgggcctt tgcacaggct    540

gttcctgctg cctggaagct catccttttg gctcactccc tcacttcctg cccaaatgtc    600

atctccatga gatcgccctg gaaacccagg actaccttcc caccttccac actcccttgc    660

cctcttgcta taattttctc tatggcatgt attaaatatt tgtttattgt ctgtcttctg    720

ccaactgcat tataagctcc ccgagagcag gcaccttctt ttgtacacag ctgtatctcc    780

agagtggtgc ttgcgggcag caggttctca ataaactcga tgaatga                  827


<210>  1372
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  1372

Met Glu Gln Gly Thr Cys Arg Trp Ser Thr Cys Ser Trp Leu Met Ala 
1               5                   10                  15      


Ala His Leu Arg Glu Gly Pro Val His Leu Ser Pro Arg Arg Arg Glu 
            20                  25                  30          


Gly Pro Asn His Tyr Pro Glu Ser Thr Gly Leu Cys Thr Gly Cys Ser 
        35                  40                  45              


Cys Cys Leu Glu Ala His Pro Phe Gly Ser Leu Pro His Phe Leu Pro 
    50                  55                  60                  


Lys Cys His Leu His Glu Ile Ala Leu Glu Thr Gln Asp Tyr Leu Pro 
65                  70                  75                  80  


Thr Phe His Thr Pro Leu Pro Ser Cys Tyr Asn Phe Leu Tyr Gly Met 
                85                  90                  95      


Tyr 
    


<210>  1373
<211>  6492
<212>  DNA
<213>  Homosapiens

<400>  1373
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct     60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag    120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga    180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata    240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt    300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac    360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct    420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt    480

tcctctggga aggatggcgc acgctgggag aacagggtac gataaccggg agatagtgat    540

gaagtacatc cattataagc tgtcgcagag gggctacgag tgggatgcgg gagatgtggg    600

cgccgcgccc ccgggggccg cccccgcacc gggcatcttc tcctcccagc ccgggcacac    660

gccccatcca gccgcatccc gggacccggt cgccaggacc tcgccgctgc agaccccggc    720

tgcccccggc gccgccgcgg ggcctgcgct cagcccggtg ccacctgtgg tccacctgac    780

cctccgccag gccggcgacg acttctcccg ccgctaccgc cgcgacttcg ccgagatgtc    840

cagccagctg cacctgacgc ccttcaccgc gcggggacgc tttgccacgg tggtggagga    900

gctcttcagg gacggggtga actgggggag gattgtggcc ttctttgagt tcggtggggt    960

catgtgtgtg gagagcgtca accgggagat gtcgcccctg gtggacaaca tcgccctgtg   1020

gatgactgag tacctgaacc ggcacctgca cacctggatc caggataacg gaggctggga   1080

tgcctttgtg gaactgtacg gccccagcat gcggcctctg tttgatttct cctggctgtc   1140

tctgaagact ctgctcagtt tggccctggt gggagcttgc atcaccctgg gtgcctatct   1200

gggccacaag tgaagtcaac atgcctgccc caaacaaata tgcaaaaggt tcactaaagc   1260

agtagaaata atatgcattg tcagtgatgt accatgaaac aaagctgcag gctgtttaag   1320

aaaaaataac acacatataa acatcacaca cacagacaga cacacacaca cacaacaatt   1380

aacagtcttc aggcaaaacg tcgaatcagc tatttactgc caaagggaaa tatcatttat   1440

tttttacatt attaagaaaa aaagatttat ttatttaaga cagtcccatc aaaactcctg   1500

tctttggaaa tccgaccact aattgccaag caccgcttcg tgtggctcca cctggatgtt   1560

ctgtgcctgt aaacatagat tcgctttcca tgttgttggc cggatcacca tctgaagagc   1620

agacggatgg aaaaaggacc tgatcattgg ggaagctggc tttctggctg ctggaggctg   1680

gggagaaggt gttcattcac ttgcatttct ttgccctggg ggctgtgata ttaacagagg   1740

gagggttcct gtggggggaa gtccatgcct ccctggcctg aagaagagac tctttgcata   1800

tgactcacat gatgcatacc tggtgggagg aaaagagttg ggaacttcag atggacctag   1860

tacccactga gatttccacg ccgaaggaca gcgatgggaa aaatgccctt aaatcatagg   1920

aaagtatttt tttaagctac caattgtgcc gagaaaagca ttttagcaat ttatacaata   1980

tcatccagta ccttaagccc tgattgtgta tattcatata ttttggatac gcacccccca   2040

actcccaata ctggctctgt ctgagtaaga aacagaatcc tctggaactt gaggaagtga   2100

acatttcggt gacttccgca tcaggaaggc tagagttacc cagagcatca ggccgccaca   2160

agtgcctgct tttaggagac cgaagtccgc agaacctgcc tgtgtcccag cttggaggcc   2220

tggtcctgga actgagccgg ggccctcact ggcctcctcc agggatgatc aacagggcag   2280

tgtggtctcc gaatgtctgg aagctgatgg agctcagaat tccactgtca agaaagagca   2340

gtagaggggt gtggctgggc ctgtcaccct ggggccctcc aggtaggccc gttttcacgt   2400

ggagcatggg agccacgacc cttcttaaga catgtatcac tgtagaggga aggaacagag   2460

gccctgggcc cttcctatca gaaggacatg gtgaaggctg ggaacgtgag gagaggcaat   2520

ggccacggcc cattttggct gtagcacatg gcacgttggc tgtgtggcct tggcccacct   2580

gtgagtttaa agcaaggctt taaatgactt tggagagggt cacaaatcct aaaagaagca   2640

ttgaagtgag gtgtcatgga ttaattgacc cctgtctatg gaattacatg taaaacatta   2700

tcttgtcact gtagtttggt tttatttgaa aacctgacaa aaaaaaagtt ccaggtgtgg   2760

aatatggggg ttatctgtac atcctggggc attaaaaaaa aaatcaatgg tggggaacta   2820

taaagaagta acaaaagaag tgacatcttc agcaaataaa ctaggaaatt tttttttctt   2880

ccagtttaga atcagccttg aaacattgat ggaataactc tgtggcatta ttgcattata   2940

taccatttat ctgtattaac tttggaatgt actctgttca atgtttaatg ctgtggttga   3000

tatttcgaaa gctgctttaa aaaaatacat gcatctcagc gtttttttgt ttttaattgt   3060

atttagttat ggcctataca ctatttgtga gcaaaggtga tcgttttctg tttgagattt   3120

ttatctcttg attcttcaaa agcattctga gaaggtgaga taagccctga gtctcagcta   3180

cctaagaaaa acctggatgt cactggccac tgaggagctt tgtttcaacc aagtcatgtg   3240

catttccacg tcaacagaat tgtttattgt gacagttata tctgttgtcc ctttgacctt   3300

gtttcttgaa ggtttcctcg tccctgggca attccgcatt taattcatgg tattcaggat   3360

tacatgcatg tttggttaaa cccatgagat tcattcagtt aaaaatccag atggcaaatg   3420

accagcagat tcaaatctat ggtggtttga cctttagaga gttgctttac gtggcctgtt   3480

tcaacacaga cccacccaga gccctcctgc cctccttccg cgggggcttt ctcatggctg   3540

tccttcaggg tcttcctgaa atgcagtggt gcttacgctc caccaagaaa gcaggaaacc   3600

tgtggtatga agccagacct ccccggcggg cctcagggaa cagaatgatc agacctttga   3660

atgattctaa tttttaagca aaatattatt ttatgaaagg tttacattgt caaagtgatg   3720

aatatggaat atccaatcct gtgctgctat cctgccaaaa tcattttaat ggagtcagtt   3780

tgcagtatgc tccacgtggt aagatcctcc aagctgcttt agaagtaaca atgaagaacg   3840

tggacgtttt taatataaag cctgttttgt cttttgttgt tgttcaaacg ggattcacag   3900

agtatttgaa aaatgtatat atattaagag gtcacggggg ctaattgctg gctggctgcc   3960

ttttgctgtg gggttttgtt acctggtttt aataacagta aatgtgccca gcctcttggc   4020

cccagaactg tacagtattg tggctgcact tgctctaaga gtagttgatg ttgcattttc   4080

cttattgtta aaaacatgtt agaagcaatg aatgtatata aaagcctcaa ctagtcattt   4140

ttttctcctc ttcttttttt tcattatatc taattatttt gcagttgggc aacagagaac   4200

catccctatt ttgtattgaa gagggattca catctgcatc ttaactgctc tttatgaatg   4260

aaaaaacagt cctctgtatg tactcctctt tacactggcc agggtcagag ttaaatagag   4320

tatatgcact ttccaaattg gggacaaggg ctctaaaaaa agccccaaaa ggagaagaac   4380

atctgagaac ctcctcggcc ctcccagtcc ctcgctgcac aaatactccg caagagaggc   4440

cagaatgaca gctgacaggg tctatggcca tcgggtcgtc tccgaagatt tggcaggggc   4500

agaaaactct ggcaggctta agatttggaa taaagtcaca gaattaagga agcacctcaa   4560

tttagttcaa acaagacgcc aacattctct ccacagctca cttacctctc tgtgttcaga   4620

tgtggccttc catttatatg tgatctttgt tttattagta aatgcttatc atctaaagat   4680

gtagctctgg cccagtggga aaaattagga agtgattata aatcgagagg agttataata   4740

atcaagatta aatgtaaata atcagggcaa tcccaacaca tgtctagctt tcacctccag   4800

gatctattga gtgaacagaa ttgcaaatag tctctatttg taattgaact tatcctaaaa   4860

caaatagttt ataaatgtga acttaaactc taattaattc caactgtact tttaaggcag   4920

tggctgtttt tagactttct tatcacttat agttagtaat gtacacctac tctatcagag   4980

aaaaacagga aaggctcgaa atacaagcca ttctaaggaa attagggagt cagttgaaat   5040

tctattctga tcttattctg tggtgtcttt tgcagcccag acaaatgtgg ttacacactt   5100

tttaagaaat acaattctac attgtcaagc ttatgaaggt tccaatcaga tctttattgt   5160

tattcaattt ggatctttca gggatttttt ttttaaatta ttatgggaca aaggacattt   5220

gttggagggg tgggagggag gaagaatttt taaatgtaaa acattcccaa gtttggatca   5280

gggagttgga agttttcaga ataaccagaa ctaagggtat gaaggacctg tattggggtc   5340

gatgtgatgc ctctgcgaag aaccttgtgt gacaaatgag aaacattttg aagtttgtgg   5400

tacgaccttt agattccaga gacatcagca tggctcaaag tgcagctccg tttggcagtg   5460

caatggtata aatttcaagc tggatatgtc taatgggtat ttaaacaata aatgtgcagt   5520

tttaactaac aggatattta atgacaacct tctggttggt agggacatct gtttctaaat   5580

gtttattatg tacaatacag aaaaaaattt tataaaatta agcaatgtga aactgaattg   5640

gagagtgata atacaagtcc tttagtctta cccagtgaat cattctgttc catgtctttg   5700

gacaaccatg accttggaca atcatgaaat atgcatctca ctggatgcaa agaaaatcag   5760

atggagcatg aatggtactg taccggttca tctggactgc cccagaaaaa taacttcaag   5820

caaacatcct atcaacaaca aggttgttct gcataccaag ctgagcacag aagatgggaa   5880

cactggtgga ggatggaaag gctcgctcaa tcaagaaaat tctgagacta ttaataaata   5940

agactgtagt gtagatactg agtaaatcca tgcacctaaa ccttttggaa aatctgccgt   6000

gggccctcca gatagctcat ttcattaagt ttttccctcc aaggtagaat ttgcaagagt   6060

gacagtggat tgcatttctt ttggggaagc tttcttttgg tggttttgtt tattatacct   6120

tcttaagttt tcaaccaagg tttgcttttg ttttgagtta ctggggttat ttttgtttta   6180

aataaaaata agtgtacaat aagtgttttt gtattgaaag cttttgttat caagattttc   6240

atacttttac cttccatggc tctttttaag attgatactt ttaagaggtg gctgatattc   6300

tgcaacactg tacacataaa aaatacggta aggatacttt acatggttaa ggtaaagtaa   6360

gtctccagtt ggccaccatt agctataatg gcactttgtt tgtgttgttg gaaaaagtca   6420

cattgccatt aaactttcct tgtctgtcta gttaatattg tgaagaaaaa taaagtacag   6480

tgtgagatac tg                                                       6492


<210>  1374
<211>  239
<212>  PRT
<213>  Homosapiens

<400>  1374

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  1375
<211>  1207
<212>  DNA
<213>  Homosapiens

<400>  1375
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct     60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag    120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga    180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata    240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt    300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac    360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct    420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt    480

tcctctggga aggatggcgc acgctgggag aacagggtac gataaccggg agatagtgat    540

gaagtacatc cattataagc tgtcgcagag gggctacgag tgggatgcgg gagatgtggg    600

cgccgcgccc ccgggggccg cccccgcacc gggcatcttc tcctcccagc ccgggcacac    660

gccccatcca gccgcatccc gggacccggt cgccaggacc tcgccgctgc agaccccggc    720

tgcccccggc gccgccgcgg ggcctgcgct cagcccggtg ccacctgtgg tccacctgac    780

cctccgccag gccggcgacg acttctcccg ccgctaccgc cgcgacttcg ccgagatgtc    840

cagccagctg cacctgacgc ccttcaccgc gcggggacgc tttgccacgg tggtggagga    900

gctcttcagg gacggggtga actgggggag gattgtggcc ttctttgagt tcggtggggt    960

catgtgtgtg gagagcgtca accgggagat gtcgcccctg gtggacaaca tcgccctgtg   1020

gatgactgag tacctgaacc ggcacctgca cacctggatc caggataacg gaggctgggt   1080

aggtgcactt ggtgatgtga gtctgggctg aggccacagg tccgagatgc gggggttgga   1140

gtgcgggtgg gctcctgggg caatgggagg ctgtggagcc ggcgaaataa aatcagagtt   1200

gttgcta                                                             1207


<210>  1376
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  1376

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 


<210>  1377
<211>  2272
<212>  DNA
<213>  Homosapiens

<400>  1377
aggcgcccgc ccgccgcgcg tgattctcgc ctcgccgcag cccagccctg cgcgccttgc     60

ccggcggccc ccgcccggcc gctccgggcc cctggccccg cggagcgatg ctgctgctgg    120

ctgccgcctt cctcgtggcc ttcgtgctgc tgctgtacat ggtgtctccg ctcatcagcc    180

ccaagcccct cgccctgccc ggggcgcatg tggtggttac aggaggttcc agtggcatcg    240

ggaagtgcat tgctatcgag tgctataaac aaggagcttt tataactctg gttgcacgaa    300

atgaggataa gctgctgcag gcaaagaaag aaattgaaat gcactctatt aatgacaaac    360

aggtggtgct ttgcatatca gttgatgtat ctcaagacta taaccaagta gagaatgtca    420

taaaacaagc acaggagaaa ctgggtccag tggacatgct ggtaaattgt gcaggaatgg    480

cagtgtcagg aaaatttgaa gatcttgaag ttagtacctt tgaaaggtta atgagcatca    540

attacctggg cagcgtgtac cccagccggg ccgtgatcac caccatgaag gagcgccggg    600

tgggcaggat cgtgtttgtg tcctcccagg caggacagtt gggattattc ggtttcacag    660

cctactctgc atccaagttt gccataaggg gattggcaga agctttgcag atggaggtga    720

agccatataa tgtctacatc acagttgctt acccaccaga cacagacaca cctggctttg    780

ccgaagaaaa cagaacaaag cctttggaga ctcgacttat ttcagagacc acatctgtgt    840

gcaaaccaga acaggtggcc aaacaaattg ttaaagatgc catacaagga aatttcaaca    900

gttcccttgg ctcagatggg tacatgctct cggccctgac ctgtgggatg gctccagtaa    960

cttctattac tgaggggctc cagcaggtgg tcaccatggg ccttttccgc actattgctt   1020

tgttttacct tggaagtttt gacagcatag ttcgtcgctg catgatgcag agagaaaaat   1080

ctgaaaatgc agacaaaact gcctaatctt cttacccctt ggaagaagac tgtttccaaa   1140

taatttgaac agcttgctgc taaatgggac ccaatttttg gcctatagac acttatgtat   1200

tgttttcgaa tacgtcagat tggaccagtg ctcttcagga atgtggctgc aagcaagggg   1260

ctagaagttc acctcctgac agtattatta atactatgca aatatggaat aggagaccat   1320

ttgattttct aggctttgtg gtagagaggt gaaggtatga gaattaatag cgtgtgaaca   1380

aagtaaagaa caggattcca gaatgatcat taaatttgtt tctatttatt cttttttgcc   1440

cccctagaga ttaagtccag aaatgtactt tctggcacat aaagaaatct tgaggacttt   1500

gtttaaacct tccataaaaa aacaattttc ggtttctcgg gttctctctc tctgtctctc   1560

tgtctctctg tctctctgtc tctctgtctc tctctctctc tctctttctt tctttgtgta   1620

ttttattcaa gatgagttgg acccattgcc agtgagtctg aatgtcactg acagccctgt   1680

gttgtgctca ggactcactc tgctgctggt ggaaactcat ggcttctctc tctctttgat   1740

cccataaagc tacgaggggg acgggagagg gcagtgcaat gggaagtaaa gagatatttt   1800

ccagtaggaa aagcaatgct ttcttgtctt tagactcaaa tgcttaggga acgtttcatt   1860

tctcattcat ggggaaaggc agcctcctta aatgttttct gaagagcggt aaaatctaga   1920

agcttaagaa tttacagttc cttcaataac catgatgacc tgaagttcac ctatcccatt   1980

ttagcatcta cttgtttttc ccatctcttc ctttccaatt ttgcttatac tgctgtaata   2040

tttttgtaaa aaaaaaaaaa aaggaaaaaa aagaccagct aaaattttcg acttgacttt   2100

ttaacttaac tcatgaatta attaaagcaa atgaaaaaat taaaaagtgt gactttttct   2160

cggagcatat atgtagcttt taggaaaggc tgatgatggt ataaagtttg ctcattaaga   2220

aaaaaagaca aggctgattt tgaagagagt tgcttttgaa ataaaatgat ca           2272


<210>  1378
<211>  332
<212>  PRT
<213>  Homosapiens

<400>  1378

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Arg Leu Met Ser Ile 
    130                 135                 140                 


Asn Tyr Leu Gly Ser Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155                 160 


Lys Glu Arg Arg Val Gly Arg Ile Val Phe Val Ser Ser Gln Ala Gly 
                165                 170                 175     


Gln Leu Gly Leu Phe Gly Phe Thr Ala Tyr Ser Ala Ser Lys Phe Ala 
            180                 185                 190         


Ile Arg Gly Leu Ala Glu Ala Leu Gln Met Glu Val Lys Pro Tyr Asn 
        195                 200                 205             


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
    210                 215                 220                 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
225                 230                 235                 240 


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
                245                 250                 255     


Asp Ala Ile Gln Gly Asn Phe Asn Ser Ser Leu Gly Ser Asp Gly Tyr 
            260                 265                 270         


Met Leu Ser Ala Leu Thr Cys Gly Met Ala Pro Val Thr Ser Ile Thr 
        275                 280                 285             


Glu Gly Leu Gln Gln Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala 
    290                 295                 300                 


Leu Phe Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met 
305                 310                 315                 320 


Gln Arg Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
                325                 330         


<210>  1379
<211>  3337
<212>  DNA
<213>  Homosapiens

<400>  1379
gcggaagttt ggtggggagg gtcggagctc tggtggagag agtgttgtct aaaacaagtt     60

ccggaaggga ggctgccctt cgcggtccga gaaccaccgg cctccccagt ttgagggctg    120

ttaccccgtg cgcgcttcga cgttgctgct gttggctctc ctcgcccctc gttcccttgg    180

gaaccgcctg ggaactccgc catgtcatcc acttcgccca acctccagaa agcgatagat    240

ctggctagca aagcagcgca agaagacaag gctgggaact acgaagaagc ccttcagctc    300

tatcagcatg ctgtgcagta ttttcttcat gtcgttaaat atgaagcaca gggtgataaa    360

gccaagcaaa gtatcagggc aaagtgtaca gaatatcttg atagagcaga aaaactaaag    420

gagtacctga aaaataaaga gaaaaaagca cagaagccag tgaaagaagg acagccgagt    480

ccagcagatg agaaggggaa tgacagtgat ggggaaggag aatctgatga tcctgaaaaa    540

aagaaactac agaatcaact tcaaggtgcc attgttatag aacgaccaaa tgtgaaatgg    600

agtgacgttg ctggacttga aggagccaaa gaagcactga aagaggctgt gatactgcct    660

attaaatttc ctcatctttt tacaggcaag agaacacctt ggaggggaat cctattattt    720

gggccgcctg gaacaggaaa gtcctactta gccaaagctg tagcaacaga agccaacaac    780

tcaacatttt tttcaatatc ttcctctgat cttgtttcta agtggctagg tgaaagtgaa    840

aaactggtta agaatttatt ccaacttgcc agagagaaca agccctccat tatcttcatt    900

gatgaaattg attctctctg tggttcaaga agtgaaaatg aaagtgaagc cgcacgtaga    960

attaagacgg agttcctagt gcaaatgcaa ggggttggtg tagacaatga tggaattttg   1020

gttctgggag ctacaaatat accctgggtt ctggattctg ccattaggcg aagatttgag   1080

aaacgaattt atattccctt gccggaaccc catgcccgag cagcaatgtt taaactgcac   1140

ctagggacca ctcagaacag tctcacggaa gcagactttc gggaacttgg gaggaaaaca   1200

gatggttatt caggggcaga tataagtatc attgtacgtg atgcccttat gcagcctgtt   1260

aggaaagtac agtcagctac tcattttaaa aaggttcgcg gaccttcccg agctgatcct   1320

aaccatcttg tagatgatct gctaacacct tgctctccag gtgaccctgg tgccattgaa   1380

atgacatgga tggatgtccc tggagataaa cttttggagc cagttgtttc catgtcggat   1440

atgttgcggt cactatctaa cacaaaacct acagtcaatg aacatgactt gttgaaatta   1500

aagaagttta cagaagattt tggtcaagaa ggctaagcca aagacaagga agatgcttac   1560

catatgtatt ctttctttca tagatatttt tgtctatttg gatcgcatta attgtttcca   1620

gtaaaactct tttaccacag ggaaatacac atctcacttc agagttccat taggttttat   1680

attgtacttt tcctccatta cttattaaat actcctatta acaaaaggta caaaataaca   1740

ggttatgagg aaatgagcga tatatgaacg gcataaaaac agaaattacc cagtaaaaag   1800

gatgtcagaa attgacatac aaatatttac aatttttatg aatggtggtc tttgcaaaga   1860

gcatttatat tttctttttt ttttactaaa atgatatagg gtttatttta tattttcaaa   1920

aaaattgtta aacatcattc ttatcaatgt aaaatttacg ttattaaaaa attacaaatg   1980

atagaatctt tactcaggga tgggcaataa aacagcaaag agctttgtga ttgggtttga   2040

aagattttga attatagaca gtgctcttaa tagtttttaa taagttgata tttttttctg   2100

tgtagattta aataatttct ttaaaagcgt aagctttggc tgggcatggt ggcttatgcc   2160

tgtaatccca gcactttggg aggctacgat gggtggatca cctgaggtca ggagttcaag   2220

accagtctgg ccaacatggt gaaatgccgt ctctactaaa aatacaaaaa ttagctgggc   2280

atgatggcga gtgtctgtaa tcccagctac tcaggaggct gaggcgggag aatcacttga   2340

acctgggagg cagaggttgc agtgagctga gatcgcgcta ctgcattcca gcctgggcgc   2400

cgagatagcg ccattgcact ccagcctggg cgactgaata aaactctgtc tcaaaaaaaa   2460

acaaaaacgg taagctttta tatttaatta actgatacct ttcactgtgc aatctcaaga   2520

ggaagatttt ctaaattaga cattgtcttt accttaaaga agaaaattgt ctatttcagt   2580

gtctttttta gcaagattga ccaaaacagg tggtaggtgt gtaattttta actgtcatga   2640

aatactgtaa tgcgcacctt tgctaataag gaaatggtct ccctttgaat tatgggaagt   2700

ttcttgtctg tgatatgggg tgtctgtgta catatatgta tatttccttt tttaatacag   2760

gataataata tggggtcttg tccttcacct tttaagttca gggaacagtt tgtcctgacc   2820

acacatatgt tatcagtgta atgctttatg aagctttaga aatgagctca tgactcatta   2880

aaaaataata aacgatgcta ttttaatatt ttcaaataaa taatctgagg atgtgtttca   2940

tactttagca tcaacgctga gttgtgcctt gtagaattgc attgtctata catgcaaaag   3000

actattaagt taggatgaac tagattccct aattacagtg aaattctatc ttgcaaatgc   3060

tatagaataa cttgcatttt aaagtgtatt tgcacatttt acatatgcta tgtggttgcc   3120

tttgggtttt ctgtacagat tgtttttgtt attaaatgga aaaggcctga attatgctct   3180

tatgtgaagt aaattgatat aacctattga ctgtattctg tgtattattc tttattttgg   3240

gaccttctgt gtaaaagaaa atattaccta aattggttag atacaaagaa atcattaaaa   3300

ttattaatgt atatatgaaa aaaaaaaaaa aaaaaaa                            3337


<210>  1380
<211>  444
<212>  PRT
<213>  Homosapiens

<400>  1380

Met Ser Ser Thr Ser Pro Asn Leu Gln Lys Ala Ile Asp Leu Ala Ser 
1               5                   10                  15      


Lys Ala Ala Gln Glu Asp Lys Ala Gly Asn Tyr Glu Glu Ala Leu Gln 
            20                  25                  30          


Leu Tyr Gln His Ala Val Gln Tyr Phe Leu His Val Val Lys Tyr Glu 
        35                  40                  45              


Ala Gln Gly Asp Lys Ala Lys Gln Ser Ile Arg Ala Lys Cys Thr Glu 
    50                  55                  60                  


Tyr Leu Asp Arg Ala Glu Lys Leu Lys Glu Tyr Leu Lys Asn Lys Glu 
65                  70                  75                  80  


Lys Lys Ala Gln Lys Pro Val Lys Glu Gly Gln Pro Ser Pro Ala Asp 
                85                  90                  95      


Glu Lys Gly Asn Asp Ser Asp Gly Glu Gly Glu Ser Asp Asp Pro Glu 
            100                 105                 110         


Lys Lys Lys Leu Gln Asn Gln Leu Gln Gly Ala Ile Val Ile Glu Arg 
        115                 120                 125             


Pro Asn Val Lys Trp Ser Asp Val Ala Gly Leu Glu Gly Ala Lys Glu 
    130                 135                 140                 


Ala Leu Lys Glu Ala Val Ile Leu Pro Ile Lys Phe Pro His Leu Phe 
145                 150                 155                 160 


Thr Gly Lys Arg Thr Pro Trp Arg Gly Ile Leu Leu Phe Gly Pro Pro 
                165                 170                 175     


Gly Thr Gly Lys Ser Tyr Leu Ala Lys Ala Val Ala Thr Glu Ala Asn 
            180                 185                 190         


Asn Ser Thr Phe Phe Ser Ile Ser Ser Ser Asp Leu Val Ser Lys Trp 
        195                 200                 205             


Leu Gly Glu Ser Glu Lys Leu Val Lys Asn Leu Phe Gln Leu Ala Arg 
    210                 215                 220                 


Glu Asn Lys Pro Ser Ile Ile Phe Ile Asp Glu Ile Asp Ser Leu Cys 
225                 230                 235                 240 


Gly Ser Arg Ser Glu Asn Glu Ser Glu Ala Ala Arg Arg Ile Lys Thr 
                245                 250                 255     


Glu Phe Leu Val Gln Met Gln Gly Val Gly Val Asp Asn Asp Gly Ile 
            260                 265                 270         


Leu Val Leu Gly Ala Thr Asn Ile Pro Trp Val Leu Asp Ser Ala Ile 
        275                 280                 285             


Arg Arg Arg Phe Glu Lys Arg Ile Tyr Ile Pro Leu Pro Glu Pro His 
    290                 295                 300                 


Ala Arg Ala Ala Met Phe Lys Leu His Leu Gly Thr Thr Gln Asn Ser 
305                 310                 315                 320 


Leu Thr Glu Ala Asp Phe Arg Glu Leu Gly Arg Lys Thr Asp Gly Tyr 
                325                 330                 335     


Ser Gly Ala Asp Ile Ser Ile Ile Val Arg Asp Ala Leu Met Gln Pro 
            340                 345                 350         


Val Arg Lys Val Gln Ser Ala Thr His Phe Lys Lys Val Arg Gly Pro 
        355                 360                 365             


Ser Arg Ala Asp Pro Asn His Leu Val Asp Asp Leu Leu Thr Pro Cys 
    370                 375                 380                 


Ser Pro Gly Asp Pro Gly Ala Ile Glu Met Thr Trp Met Asp Val Pro 
385                 390                 395                 400 


Gly Asp Lys Leu Leu Glu Pro Val Val Ser Met Ser Asp Met Leu Arg 
                405                 410                 415     


Ser Leu Ser Asn Thr Lys Pro Thr Val Asn Glu His Asp Leu Leu Lys 
            420                 425                 430         


Leu Lys Lys Phe Thr Glu Asp Phe Gly Gln Glu Gly 
        435                 440                 


<210>  1381
<211>  2558
<212>  DNA
<213>  Homosapiens

<400>  1381
ttgtgctcct cgcttgcctg ttccttttcc acgcattttc caggataact gtgactccag     60

gcccgcaatg gatgccctgc aactagcaaa ttcggctttt gccgttgatc tgttcaaaca    120

actatgtgaa aaggagccac tgggcaatgt cctcttctct ccaatctgtc tctccacctc    180

tctgtcactt gctcaagtgg gtgctaaagg tgacactgca aatgaaattg gacaggttct    240

tcattttgaa aatgtcaaag atataccctt tggatttcaa acagtaacat cggatgtaaa    300

caaacttagt tccttttact cactgaaact aatcaagcgg ctctacgtag acaaatctct    360

gaatctttct acagagttca tcagctctac gaagagaccc tatgcaaagg aattggaaac    420

tgttgacttc aaagataaat tggaagaaac gaaaggtcag atcaacaact caattaagga    480

tctcacagat ggccactttg agaacatttt agctgacaac agtgtgaacg accagaccaa    540

aatccttgtg gttaatgctg cctactttgt tggcaagtgg atgaagaaat ttcctgaatc    600

agaaacaaaa gaatgtcctt tcagactcaa caagacagac accaaaccag tgcagatgat    660

gaacatggag gccacgttct gtatgggaaa cattgacagt atcaattgta agatcataga    720

gcttcctttt caaaataagc atctcagcat gttcatccta ctacccaagg atgtggagga    780

tgagtccaca ggcttggaga agattgaaaa acaactcaac tcagagtcac tgtcacagtg    840

gactaatccc agcaccatgg ccaatgccaa ggtcaaactc tccattccaa aatttaaggt    900

ggaaaagatg attgatccca aggcttgtct ggaaaatcta gggctgaaac atatcttcag    960

tgaagacaca tctgatttct ctggaatgtc agagaccaag ggagtggccc tatcaaatgt   1020

tatccacaaa gtgtgcttag aaataactga agatggtggg gattccatag aggtgccagg   1080

agcacggatc ctgcagcaca aggatgaatt gaatgctgac catcccttta tttacatcat   1140

caggcacaac aaaactcgaa acatcatttt ctttggcaaa ttctgttctc cttaagtggc   1200

atagcccatg ttaagtcctc cctgactttt ctgtggatgc cgatttctgt aaactctgca   1260

tccagagatt cattttctag atacaataaa ttgctaatgt tgctggatca ggaagccgcc   1320

agtacttgtc atatgtagcc ttcacacaga tagacctttt tttttttcca attctatctt   1380

ttgtttcctt ttttcccata agacaatgac atacgctttt aatgaaaagg aatcacgtta   1440

gaggaaaaat atttattcat tatttgtcaa attgtccggg gtagttggca gaaatacagt   1500

cttccacaaa gaaaattcct ataaggaaga tttggaagct cttcttccca gcactatgct   1560

ttccttcttt gggatagaga atgttccaga cattctcgct tccctgaaag actgaagaaa   1620

gtgtagtgca tgggacccac gaaactgccc tggctccagt gaaacttggg cacatgctca   1680

ggctactata ggtccagaag tccttatgtt aagccctggc aggcaggtgt ttattaaaat   1740

tctgaatttt ggggattttc aaaagataat attttacata cactgtatgt tatagaactt   1800

catggatcag atctggggca gcaacctata aatcaacacc ttaatatgct gcaacaaaat   1860

gtagaatatt cagacaaaat ggatacataa agactaagta gcccataagg ggtcaaaatt   1920

tgctgccaaa tgcgtatgcc accaacttac aaaaacactt cgttcgcaga gcttttcaga   1980

ttgtggaatg ttggataagg aattatagac ctctagtagc tgaaatgcaa gaccccaaga   2040

ggaagttcag atcttaatat aaattcactt tcatttttga tagctgtccc atctggtcat   2100

gtggttggca ctagactggt ggcaggggct tctagctgac tcgcacaggg attctcacaa   2160

tagccgatat cagaatttgt gttgaaggaa cttgtctctt catctaatat gatagcggga   2220

aaaggagagg aaactactgc ctttagaaaa tataagtaaa gtgattaaag tgctcacgtt   2280

accttgacac atagtttttc agtctatggg tttagttact ttagatggca agcatgtaac   2340

ttatattaat agtaatttgt aaagttgggt ggataagcta tccctgttgc cggttcatgg   2400

attacttctc tataaaaaat atatatttac caaaaaattt tgtgacattc cttctcccat   2460

ctcttccttg acatgcattg taaataggtt cttcttgttc tgagattcaa tattgaattt   2520

ctcctatgct attgacaata aaatattatt gaactacc                           2558


<210>  1382
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  1382

Met Asp Ala Leu Gln Leu Ala Asn Ser Ala Phe Ala Val Asp Leu Phe 
1               5                   10                  15      


Lys Gln Leu Cys Glu Lys Glu Pro Leu Gly Asn Val Leu Phe Ser Pro 
            20                  25                  30          


Ile Cys Leu Ser Thr Ser Leu Ser Leu Ala Gln Val Gly Ala Lys Gly 
        35                  40                  45              


Asp Thr Ala Asn Glu Ile Gly Gln Val Leu His Phe Glu Asn Val Lys 
    50                  55                  60                  


Asp Ile Pro Phe Gly Phe Gln Thr Val Thr Ser Asp Val Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Phe Tyr Ser Leu Lys Leu Ile Lys Arg Leu Tyr Val Asp Lys 
                85                  90                  95      


Ser Leu Asn Leu Ser Thr Glu Phe Ile Ser Ser Thr Lys Arg Pro Tyr 
            100                 105                 110         


Ala Lys Glu Leu Glu Thr Val Asp Phe Lys Asp Lys Leu Glu Glu Thr 
        115                 120                 125             


Lys Gly Gln Ile Asn Asn Ser Ile Lys Asp Leu Thr Asp Gly His Phe 
    130                 135                 140                 


Glu Asn Ile Leu Ala Asp Asn Ser Val Asn Asp Gln Thr Lys Ile Leu 
145                 150                 155                 160 


Val Val Asn Ala Ala Tyr Phe Val Gly Lys Trp Met Lys Lys Phe Pro 
                165                 170                 175     


Glu Ser Glu Thr Lys Glu Cys Pro Phe Arg Leu Asn Lys Thr Asp Thr 
            180                 185                 190         


Lys Pro Val Gln Met Met Asn Met Glu Ala Thr Phe Cys Met Gly Asn 
        195                 200                 205             


Ile Asp Ser Ile Asn Cys Lys Ile Ile Glu Leu Pro Phe Gln Asn Lys 
    210                 215                 220                 


His Leu Ser Met Phe Ile Leu Leu Pro Lys Asp Val Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Glu Lys Ile Glu Lys Gln Leu Asn Ser Glu Ser Leu Ser 
                245                 250                 255     


Gln Trp Thr Asn Pro Ser Thr Met Ala Asn Ala Lys Val Lys Leu Ser 
            260                 265                 270         


Ile Pro Lys Phe Lys Val Glu Lys Met Ile Asp Pro Lys Ala Cys Leu 
        275                 280                 285             


Glu Asn Leu Gly Leu Lys His Ile Phe Ser Glu Asp Thr Ser Asp Phe 
    290                 295                 300                 


Ser Gly Met Ser Glu Thr Lys Gly Val Ala Leu Ser Asn Val Ile His 
305                 310                 315                 320 


Lys Val Cys Leu Glu Ile Thr Glu Asp Gly Gly Asp Ser Ile Glu Val 
                325                 330                 335     


Pro Gly Ala Arg Ile Leu Gln His Lys Asp Glu Leu Asn Ala Asp His 
            340                 345                 350         


Pro Phe Ile Tyr Ile Ile Arg His Asn Lys Thr Arg Asn Ile Ile Phe 
        355                 360                 365             


Phe Gly Lys Phe Cys Ser Pro 
    370                 375 


<210>  1383
<211>  1218
<212>  DNA
<213>  Homosapiens

<400>  1383
atggactctc ttgttacagc aaacaccaaa ttttgctttg atctttttca agagataggc     60

aaagatgatc gtcataaaaa catatttttc tctcccctga gcctctcagc tgcccttggt    120

atggtacgct tgggtgctag aagtgacagt gcacatcaga ttgatgaggt actacacttc    180

aacgaatttt cccagaatga aagcaaagaa cctgaccctt gtctgaaaag caacaaacaa    240

aaagctgggt ccttaaacaa tgagagcgga ctggtcagct gctactttgg gcagcttctc    300

tccaaattag acaggatcaa gactgattac acactgagta ttgccaacag gctttatgga    360

gagcaggaat tcccaatctg tcaggaatac ttagatggtg tgattcaatt ttaccacacg    420

acgattgaaa gtgttgattt ccaaaaaaac cctgaaaaat ccagacaaga gattaacttc    480

tgggttgaat gtcaatccca aggtaaaatc aaggaactct tcagcaagga cgctattaat    540

gctgagactg tgctggtact ggtgaatgct gtttacttca aggccaaatg ggaaacatac    600

tttgaccatg aaaacacggt ggatgcacct ttctgtctaa atgcgaatga aaacaagagt    660

gtgaagatga tgacgcaaaa aggcctctac agaattggct tcatagagga ggtgaaggca    720

cagatcctgg aaatgaggta caccaagggg aagctcagca tgttcgtgct gctgccatct    780

cactctaaag ataacctgaa gggtctggaa gagcttgaaa ggaaaatcac ctatgaaaaa    840

atggtggcct ggagcagctc agaaaacatg tcagaagaat cggtggtcct gtccttcccc    900

cggttcaccc tggaagacag ctatgatctc aattccattt tacaagacat gggcattacg    960

gatatctttg atgaaacgag ggctgatctt actggaatct ctccaagtcc caatttgtac   1020

ttgtcaaaaa ttatccacaa aacctttgtg gaggtggatg aaaacggtac ccaggcagct   1080

gcagccactg gggctgttgt ctcggaaagg tcactacgat cttgggtgga gtttaatgcc   1140

aaccaccctt ttctcttttt cattagacac aacaaaaccc aaaccattct cttttatggc   1200

agggtctgct ctccttaa                                                 1218


<210>  1384
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  1384

Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe 
1               5                   10                  15      


Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro 
            20                  25                  30          


Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser 
        35                  40                  45              


Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser 
    50                  55                  60                  


Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln 
65                  70                  75                  80  


Lys Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val Ser Cys Tyr Phe 
                85                  90                  95      


Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr Asp Tyr Thr Leu 
            100                 105                 110         


Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe Pro Ile Cys Gln 
        115                 120                 125             


Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr Thr Ile Glu Ser 
    130                 135                 140                 


Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln Glu Ile Asn Phe 
145                 150                 155                 160 


Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu Leu Phe Ser Lys 
                165                 170                 175     


Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val Asn Ala Val Tyr 
            180                 185                 190         


Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu Asn Thr Val Asp 
        195                 200                 205             


Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser Val Lys Met Met 
    210                 215                 220                 


Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu Glu Val Lys Ala 
225                 230                 235                 240 


Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu Ser Met Phe Val 
                245                 250                 255     


Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly Leu Glu Glu Leu 
            260                 265                 270         


Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp Ser Ser Ser Glu 
        275                 280                 285             


Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro Arg Phe Thr Leu 
    290                 295                 300                 


Glu Asp Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp Met Gly Ile Thr 
305                 310                 315                 320 


Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly Ile Ser Pro Ser 
                325                 330                 335     


Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr Phe Val Glu Val 
            340                 345                 350         


Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly Ala Val Val Ser 
        355                 360                 365             


Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala Asn His Pro Phe 
    370                 375                 380                 


Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile Leu Phe Tyr Gly 
385                 390                 395                 400 


Arg Val Cys Ser Pro 
                405 


<210>  1385
<211>  3143
<212>  DNA
<213>  Homosapiens

<400>  1385
ctataaatta aggatcccag ctacttaatt gacttatgct tcctagttcg ttgcccagcc     60

accaccgtct ctccaaaaac ccgaggtctc gctaaaatca tcatggattc acttggcgcc    120

gtcagcactc gacttgggtt tgatcttttc aaagagctga agaaaacaaa tgatggcaac    180

atcttctttt cccctgtggg catcttgact gcaattggca tggtcctcct ggggacccga    240

ggagccaccg cttcccagtt ggaggaggtg tttcactctg aaaaagagac gaagagctca    300

agaataaagg ctgaagaaaa agaggtgatt gagaacacag aagcagtaca tcaacaattc    360

caaaagtttt tgactgaaat aagcaaactc actaatgatt atgaactgaa cataaccaac    420

aggctgtttg gagaaaaaac atacctcttc cttcaaaaat acttagatta tgttgaaaaa    480

tattatcatg catctctgga acctgttgat tttgtaaatg cagccgatga aagtcgaaag    540

aagattaatt cctgggttga aagcaaaaca aatgaaaaaa tcaaggactt gttcccagat    600

ggctctatta gtagctctac caagctggtg ctggtgaaca tggtttattt taaagggcaa    660

tgggacaggg agtttaagaa agaaaatact aaggaagaga aattttggat gaataagagc    720

acaagtaaat ctgtacagat gatgacacag agccattcct ttagcttcac tttcctggag    780

gacttgcagg ccaaaattct agggattcca tataaaaaca acgacctaag catgtttgtg    840

cttctgccca acgacatcga tggcctggag aagataatag ataaaataag tcctgagaaa    900

ttggtagagt ggactagtcc agggcatatg gaagaaagaa aggtgaatct gcacttgccc    960

cggtttgagg tggaggacgg ttacgatcta gaggcggtcc tggctgccat ggggatgggc   1020

gatgccttca gtgagcacaa agccgactac tcgggaatgt cgtcaggctc cgggttgtac   1080

gcccagaagt tcctgcacag ttcctttgtg gcagtaactg aggaaggcac cgaggctgca   1140

gctgccaccg gcataggctt tactgtcaca tccgccccag gtcatgaaaa tgttcactgc   1200

aatcatccct tcctgttctt catcaggcac aatgaatcca acagcatcct cttcttcggc   1260

agattttctt ctccttaaga tgatcgttgc catggcattg ctgcttttag caaaaaacaa   1320

ctaccagtgt tactcatatg attatgaaaa tcgtccattc ttttaaatgt tgtctcactt   1380

gcatttccag tcttggccat caaatcaatg atttaatgac tccaataatg tgtgtgttta   1440

taaccatcct cgaaagtgaa atgtcctttt ttttgtgcca tgcgtaaggt gagtcaaacc   1500

aaacctcatt gataatctcc cctttggttt cctttgaaag taaattggta tcttgtagtt   1560

ttgtgcacac gaaaggagag aaagtttctc cagtaaagag tacgaactag taattttggg   1620

gggtctctct aattctggta ttttgacatg ttataatacg caagtaaaat aaaacaatag   1680

tttactcagc tcatgttact attccccaac agatattgtg gcaaatcaca cataggaaag   1740

aggatttggg aatacagtag caaaacataa attaaaactc aaatgcccag gacaaaataa   1800

aacaatatac cagatggaga ggatgcccgt attttcatct tccattctaa cattatccat   1860

tgttagatgc ataagcattt tgatattgtg taataaatgt ggtatttgag aagataaatg   1920

atgtagttga tcagtaatcc tcctctatca cctttttaga ctttgtaagg taaatatttg   1980

gactaacttt tagaaaagtt tccctttttt tctccattta catttttctg gttttttttt   2040

ttttttttga gtgaggtacg agtattacca aatgatattt tctgaagatg ctttttggaa   2100

agctctgaat ctatacctaa tgctcttaat tattggcttg tttcattttt ttcctccagt   2160

ttttaacaag atcacataac tggcttattt ttaacagctt tgtcaaacta caatttacat   2220

gccgtaaaat gtacacactg taattttata attcattgac ttttagtaaa ttttctagcg   2280

ttatgcatcg ccacaatcca gttttagaat atttccatga ccctaagaag tttcctcatg   2340

tctattaata ttcccaatcc taggcaccac tgagttgttt tctgtcttta taagtttttc   2400

tttctacatc ttatataaat ggaatcataa tacatgtagt attttgtgtc tggcgtcttg   2460

cacttagcat ggtgttcttg aggttcatct gttgtagtat gtattgatac ttaggatttt   2520

tttattgccg aatactattc cattgcatgg aaaagaccta ttttatttct aggttcacca   2580

gttgagggac atttggattg ttcccacttc ttgggctgtt aggaataatg ttgctctgaa   2640

catgtaaata aagatctttg tgttcacata tgtttttcat tttctgttgg ggagattccc   2700

taggctagaa attgctgggc catatgaaaa atcaatagtt agctttgtaa gaaacagtca   2760

aactgttttc ccaacgtgac attttatatt cccaccagga atgtttaaaa ctagtgtctt   2820

caaatcctca ccaacatcca ggattgtgtc tttatgatta tagccatttt tgtaggtaca   2880

aagtggcatc tcatggtggt tttaatttgc atttccataa tatctaatta ggttgagctt   2940

tttttatgtg cttattggcc atttgtttga ctttgtttgg tgaaatgtat acaaatcatt   3000

tgctcatttt taatttgggt tgtctgtctt gtcttctcat tttattgagt taaatgagtt   3060

cttaataatc tctggcttac aagtccttaa tttatcaaat atatgatacg tggacatttc   3120

ctcataaaaa aaaaaaaaaa aaa                                           3143


<210>  1386
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  1386

Met Asp Ser Leu Gly Ala Val Ser Thr Arg Leu Gly Phe Asp Leu Phe 
1               5                   10                  15      


Lys Glu Leu Lys Lys Thr Asn Asp Gly Asn Ile Phe Phe Ser Pro Val 
            20                  25                  30          


Gly Ile Leu Thr Ala Ile Gly Met Val Leu Leu Gly Thr Arg Gly Ala 
        35                  40                  45              


Thr Ala Ser Gln Leu Glu Glu Val Phe His Ser Glu Lys Glu Thr Lys 
    50                  55                  60                  


Ser Ser Arg Ile Lys Ala Glu Glu Lys Glu Val Ile Glu Asn Thr Glu 
65                  70                  75                  80  


Ala Val His Gln Gln Phe Gln Lys Phe Leu Thr Glu Ile Ser Lys Leu 
                85                  90                  95      


Thr Asn Asp Tyr Glu Leu Asn Ile Thr Asn Arg Leu Phe Gly Glu Lys 
            100                 105                 110         


Thr Tyr Leu Phe Leu Gln Lys Tyr Leu Asp Tyr Val Glu Lys Tyr Tyr 
        115                 120                 125             


His Ala Ser Leu Glu Pro Val Asp Phe Val Asn Ala Ala Asp Glu Ser 
    130                 135                 140                 


Arg Lys Lys Ile Asn Ser Trp Val Glu Ser Lys Thr Asn Glu Lys Ile 
145                 150                 155                 160 


Lys Asp Leu Phe Pro Asp Gly Ser Ile Ser Ser Ser Thr Lys Leu Val 
                165                 170                 175     


Leu Val Asn Met Val Tyr Phe Lys Gly Gln Trp Asp Arg Glu Phe Lys 
            180                 185                 190         


Lys Glu Asn Thr Lys Glu Glu Lys Phe Trp Met Asn Lys Ser Thr Ser 
        195                 200                 205             


Lys Ser Val Gln Met Met Thr Gln Ser His Ser Phe Ser Phe Thr Phe 
    210                 215                 220                 


Leu Glu Asp Leu Gln Ala Lys Ile Leu Gly Ile Pro Tyr Lys Asn Asn 
225                 230                 235                 240 


Asp Leu Ser Met Phe Val Leu Leu Pro Asn Asp Ile Asp Gly Leu Glu 
                245                 250                 255     


Lys Ile Ile Asp Lys Ile Ser Pro Glu Lys Leu Val Glu Trp Thr Ser 
            260                 265                 270         


Pro Gly His Met Glu Glu Arg Lys Val Asn Leu His Leu Pro Arg Phe 
        275                 280                 285             


Glu Val Glu Asp Gly Tyr Asp Leu Glu Ala Val Leu Ala Ala Met Gly 
    290                 295                 300                 


Met Gly Asp Ala Phe Ser Glu His Lys Ala Asp Tyr Ser Gly Met Ser 
305                 310                 315                 320 


Ser Gly Ser Gly Leu Tyr Ala Gln Lys Phe Leu His Ser Ser Phe Val 
                325                 330                 335     


Ala Val Thr Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Ile Gly 
            340                 345                 350         


Phe Thr Val Thr Ser Ala Pro Gly His Glu Asn Val His Cys Asn His 
        355                 360                 365             


Pro Phe Leu Phe Phe Ile Arg His Asn Glu Ser Asn Ser Ile Leu Phe 
    370                 375                 380                 


Phe Gly Arg Phe Ser Ser Pro 
385                 390     


<210>  1387
<211>  1782
<212>  DNA
<213>  Homosapiens

<400>  1387
gggagacaca cacagcctct ctgcccacct ctgcttcctc taggaacaca ggagttccag     60

atcacatcga gttcaccatg aattcactca gtgaagccaa caccaagttc atgttcgatc    120

tgttccaaca gttcagaaaa tcaaaagaga acaacatctt ctattcccct atcagcatca    180

catcagcatt agggatggtc ctcttaggag ccaaagacaa cactgcacaa caaattagca    240

aggttcttca ctttgatcaa gtcacagaga acaccacaga aaaagctgca acatatcatg    300

ttgataggtc aggaaatgtt catcaccagt ttcaaaagct tctgactgaa ttcaacaaat    360

ccactgatgc atatgagctg aagatcgcca acaagctctt cggagaaaag acgtatcaat    420

ttttacagga atatttagat gccatcaaga aattttacca gaccagtgtg gaatctactg    480

attttgcaaa tgctccagaa gaaagtcgaa agaagattaa ctcctgggtg gaaagtcaaa    540

cgaatgaaaa aattaaaaac ctatttcctg atgggactat tggcaatgat acgacactgg    600

ttcttgtgaa cgcaatctat ttcaaagggc agtgggagaa taaatttaaa aaagaaaaca    660

ctaaagagga aaaattttgg ccaaacaaga atacatacaa atctgtacag atgatgaggc    720

aatacaattc ctttaatttt gccttgctgg aggatgtaca ggccaaggtc ctggaaatac    780

catacaaagg caaagatcta agcatgattg tgctgctgcc aaatgaaatc gatggtctgc    840

agaagcttga agagaaactc actgctgaga aattgatgga atggacaagt ttgcagaata    900

tgagagagac atgtgtcgat ttacacttac ctcggttcaa aatggaagag agctatgacc    960

tcaaggacac gttgagaacc atgggaatgg tgaatatctt caatggggat gcagacctct   1020

caggcatgac ctggagccac ggtctctcag tatctaaagt cctacacaag gcctttgtgg   1080

aggtcactga ggagggagtg gaagctgcag ctgccaccgc tgtagtagta gtcgaattat   1140

catctccttc aactaatgaa gagttctgtt gtaatcaccc tttcctattc ttcataaggc   1200

aaaataagac caacagcatc ctcttctatg gcagattctc atccccatag atgcaattag   1260

tctgtcactc catttagaaa atgttcacct agaggtgttc tggtaaactg attgctggca   1320

acaacagatt ctcttggctc atatttcttt tctatctcat cttgatgatg atagtcatca   1380

tcaagaattt aatgattaaa atagcatgcc tttctctctt tctcttaata agcccacata   1440

taaatgtact tttccttcca gaaaaatttc ccttgaggaa aaatgtccaa gataagatga   1500

atcatttaat accgtgtctt ctaaatttga aatataattc tgtttctgac ctgttttaaa   1560

tgaaccaaac caaatcatac tttctcttca aatttagcaa cctagaaaca cacatttctt   1620

tgaatttagg tgatacctaa atccttctta tgtttctaaa ttttgtgatt ctataaaaca   1680

catcatcaat aaaataatga ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa aacccaaaaa aaaaaaaaaa aaaaaaaaaa aa                      1782


<210>  1388
<211>  390
<212>  PRT
<213>  Homosapiens

<400>  1388

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Ser Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Glu Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Gln Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Thr Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Phe Pro Asp Gly Thr Ile Gly Asn Asp Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Asn Lys Phe Lys Lys 
            180                 185                 190         


Glu Asn Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Asn Thr Tyr Lys 
        195                 200                 205             


Ser Val Gln Met Met Arg Gln Tyr Asn Ser Phe Asn Phe Ala Leu Leu 
    210                 215                 220                 


Glu Asp Val Gln Ala Lys Val Leu Glu Ile Pro Tyr Lys Gly Lys Asp 
225                 230                 235                 240 


Leu Ser Met Ile Val Leu Leu Pro Asn Glu Ile Asp Gly Leu Gln Lys 
                245                 250                 255     


Leu Glu Glu Lys Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu 
            260                 265                 270         


Gln Asn Met Arg Glu Thr Cys Val Asp Leu His Leu Pro Arg Phe Lys 
        275                 280                 285             


Met Glu Glu Ser Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met 
    290                 295                 300                 


Val Asn Ile Phe Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Trp Ser 
305                 310                 315                 320 


His Gly Leu Ser Val Ser Lys Val Leu His Lys Ala Phe Val Glu Val 
                325                 330                 335     


Thr Glu Glu Gly Val Glu Ala Ala Ala Ala Thr Ala Val Val Val Val 
            340                 345                 350         


Glu Leu Ser Ser Pro Ser Thr Asn Glu Glu Phe Cys Cys Asn His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210>  1389
<211>  1694
<212>  DNA
<213>  Homosapiens

<400>  1389
ctctctgccc acctctgctt cctctaggaa cacaggagtt ccagatcaca tcgagttcac     60

catgaattca ctcagtgaag ccaacaccaa gttcatgttc gacctgttcc aacagttcag    120

aaaatcaaaa gagaacaaca tcttctattc ccctatcagc atcacatcag cattagggat    180

ggtcctctta ggagccaaag acaacactgc acaacagatt aagaaggttc ttcactttga    240

tcaagtcaca gagaacacca caggaaaagc tgcaacatat catgttgata ggtcaggaaa    300

tgttcatcac cagtttcaaa agcttctgac tgaattcaac aaatccactg atgcatatga    360

gctgaagatc gccaacaagc tcttcggaga aaaaacgtat ctatttttac aggaatattt    420

agatgccatc aagaaatttt accagaccag tgtggaatct gttgattttg caaatgctcc    480

agaagaaagt cgaaagaaga ttaactcctg ggtggaaagt caaacgaatg aaaaaattaa    540

aaacctaatt cctgaaggta atattggcag caataccaca ttggttcttg tgaacgcaat    600

ctatttcaaa gggcagtggg agaagaaatt taataaagaa gatactaaag aggaaaaatt    660

ttggccaaac aagaatacat acaagtccat acagatgatg aggcaataca catcttttca    720

ttttgcctcg ctggaggatg tacaggccaa ggtcctggaa ataccataca aaggcaaaga    780

tctaagcatg attgtgttgc tgccaaatga aatcgatggt ctccagaagc ttgaagagaa    840

actcactgct gagaaattga tggaatggac aagtttgcag aatatgagag agacacgtgt    900

cgatttacac ttacctcggt tcaaagtgga agagagctat gacctcaagg acacgttgag    960

aaccatggga atggtggata tcttcaatgg ggatgcagac ctctcaggca tgaccgggag   1020

ccgcggtctc gtgctatctg gagtcctaca caaggccttt gtggaggtta cagaggaggg   1080

agcagaagct gcagctgcca ccgctgtagt aggattcgga tcatcaccta cttcaactaa   1140

tgaagagttc cattgtaatc accctttcct attcttcata aggcaaaata agaccaacag   1200

catcctcttc tatggcagat tctcatcccc gtagatgcaa ttagtctgtc actccatttg   1260

gaaaatgttc acctgcagat gttctggtaa actgattgct ggcaacaaca gattctcttg   1320

gctcatattt cttttctttc tcatcttgat gatgatcgtc atcatcaaga atttaatgat   1380

taaaatagca tgcctttctc tctttctctt aataagccca catataaatg tactttttct   1440

tccagaaaaa ttctccttga ggaaaaatgt ccaaaataag atgaatcact taataccgta   1500

tcttctaaat ttgaaatata attctgtttg tgacctgttt taaatgaacc aaaccaaatc   1560

atactttttc tttgaattta gcaacctaga aacacacatt tctttgaatt taggtgatac   1620

ctaaatcctt cttatgtttc taaattttgt gattctataa aacacatcat caataaaata   1680

gtgacataaa atca                                                     1694


<210>  1390
<211>  390
<212>  PRT
<213>  Homosapiens

<400>  1390

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Lys Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Gly Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Leu Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Val Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Ile Pro Glu Gly Asn Ile Gly Ser Asn Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Lys Lys Phe Asn Lys 
            180                 185                 190         


Glu Asp Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Asn Thr Tyr Lys 
        195                 200                 205             


Ser Ile Gln Met Met Arg Gln Tyr Thr Ser Phe His Phe Ala Ser Leu 
    210                 215                 220                 


Glu Asp Val Gln Ala Lys Val Leu Glu Ile Pro Tyr Lys Gly Lys Asp 
225                 230                 235                 240 


Leu Ser Met Ile Val Leu Leu Pro Asn Glu Ile Asp Gly Leu Gln Lys 
                245                 250                 255     


Leu Glu Glu Lys Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu 
            260                 265                 270         


Gln Asn Met Arg Glu Thr Arg Val Asp Leu His Leu Pro Arg Phe Lys 
        275                 280                 285             


Val Glu Glu Ser Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met 
    290                 295                 300                 


Val Asp Ile Phe Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Gly Ser 
305                 310                 315                 320 


Arg Gly Leu Val Leu Ser Gly Val Leu His Lys Ala Phe Val Glu Val 
                325                 330                 335     


Thr Glu Glu Gly Ala Glu Ala Ala Ala Ala Thr Ala Val Val Gly Phe 
            340                 345                 350         


Gly Ser Ser Pro Thr Ser Thr Asn Glu Glu Phe His Cys Asn His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210>  1391
<211>  1179
<212>  DNA
<213>  Homosapiens

<400>  1391
atgggttctc tcagcacagc taacgttgaa ttttgccttg atgtgttcaa agagctgaac     60

agtaacaaca taggagataa catcttcttt tcttcgctga gtctgcttta tgctctaagc    120

atggtcctcc ttggtgccag gggagagact gcagagcaat tggagaaggt gcttcatttt    180

agtcatactg tagactcatt aaaaccaggg ttcaaggact cacctaagtg cagccaagct    240

ggaagaattc attccgagtt tggtgtcgaa ttctctcaaa tcaaccagcc agactctaac    300

tgtaccctca gcattgccaa caggctctac gggacaaaga cgatggcatt tcatcagcaa    360

tatttaagct gttctgagaa atggtatcaa gccaggttgc aaactgtgga ttttgaacag    420

tctacagaag aaacgaggaa aatgattaat gcttgggttg aaaataaaac taatggaaaa    480

gtcgcaaatc tctttggaaa gagcacaatt gacccttcat ctgtaatggt cctggtgaat    540

accatatatt tcaaaggaca aaggcaaaat aaatttcaag taagagagac agttaaaagt    600

ccttttcagc taagtgaagg taaaaatgta actgtggaaa tgatgtatca aattggaaca    660

tttaaactgg cctttgtaaa ggagccgcag atgcaagttc ttgagctgcc ctacgttaac    720

aacaaattaa gcatgattat tctgcttcca gtaggcatag ctaatctgaa acagatagaa    780

aagcagctga attcggggac gtttcatgag tggacaagct cttctaacat gatggaaaga    840

gaagttgaag tacacctccc cagattcaaa cttgaaatta agtatgagct aaattccctg    900

ttaaaacctc taggggtgac agatctcttc aaccaggtca aagctgatct ttctggaatg    960

tcaccaacca agggcctata tttatcaaaa gccatccaca agtcatacct ggatgtcagc   1020

gaagagggca cggaggcagc agcagccact ggggacagca tcgctgtaaa aagcctacca   1080

atgagagctc agttcaaggc gaaccacccc ttcctgttct ttataaggca cactcatacc   1140

aacacgatcc tattctgtgg caagcttgcc tctccctaa                          1179


<210>  1392
<211>  392
<212>  PRT
<213>  Homosapiens

<400>  1392

Met Gly Ser Leu Ser Thr Ala Asn Val Glu Phe Cys Leu Asp Val Phe 
1               5                   10                  15      


Lys Glu Leu Asn Ser Asn Asn Ile Gly Asp Asn Ile Phe Phe Ser Ser 
            20                  25                  30          


Leu Ser Leu Leu Tyr Ala Leu Ser Met Val Leu Leu Gly Ala Arg Gly 
        35                  40                  45              


Glu Thr Ala Glu Gln Leu Glu Lys Val Leu His Phe Ser His Thr Val 
    50                  55                  60                  


Asp Ser Leu Lys Pro Gly Phe Lys Asp Ser Pro Lys Cys Ser Gln Ala 
65                  70                  75                  80  


Gly Arg Ile His Ser Glu Phe Gly Val Glu Phe Ser Gln Ile Asn Gln 
                85                  90                  95      


Pro Asp Ser Asn Cys Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Thr 
            100                 105                 110         


Lys Thr Met Ala Phe His Gln Gln Tyr Leu Ser Cys Ser Glu Lys Trp 
        115                 120                 125             


Tyr Gln Ala Arg Leu Gln Thr Val Asp Phe Glu Gln Ser Thr Glu Glu 
    130                 135                 140                 


Thr Arg Lys Met Ile Asn Ala Trp Val Glu Asn Lys Thr Asn Gly Lys 
145                 150                 155                 160 


Val Ala Asn Leu Phe Gly Lys Ser Thr Ile Asp Pro Ser Ser Val Met 
                165                 170                 175     


Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Gln Arg Gln Asn Lys Phe 
            180                 185                 190         


Gln Val Arg Glu Thr Val Lys Ser Pro Phe Gln Leu Ser Glu Gly Lys 
        195                 200                 205             


Asn Val Thr Val Glu Met Met Tyr Gln Ile Gly Thr Phe Lys Leu Ala 
    210                 215                 220                 


Phe Val Lys Glu Pro Gln Met Gln Val Leu Glu Leu Pro Tyr Val Asn 
225                 230                 235                 240 


Asn Lys Leu Ser Met Ile Ile Leu Leu Pro Val Gly Ile Ala Asn Leu 
                245                 250                 255     


Lys Gln Ile Glu Lys Gln Leu Asn Ser Gly Thr Phe His Glu Trp Thr 
            260                 265                 270         


Ser Ser Ser Asn Met Met Glu Arg Glu Val Glu Val His Leu Pro Arg 
        275                 280                 285             


Phe Lys Leu Glu Ile Lys Tyr Glu Leu Asn Ser Leu Leu Lys Pro Leu 
    290                 295                 300                 


Gly Val Thr Asp Leu Phe Asn Gln Val Lys Ala Asp Leu Ser Gly Met 
305                 310                 315                 320 


Ser Pro Thr Lys Gly Leu Tyr Leu Ser Lys Ala Ile His Lys Ser Tyr 
                325                 330                 335     


Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Asp 
            340                 345                 350         


Ser Ile Ala Val Lys Ser Leu Pro Met Arg Ala Gln Phe Lys Ala Asn 
        355                 360                 365             


His Pro Phe Leu Phe Phe Ile Arg His Thr His Thr Asn Thr Ile Leu 
    370                 375                 380                 


Phe Cys Gly Lys Leu Ala Ser Pro 
385                 390         


<210>  1393
<211>  2249
<212>  DNA
<213>  Homosapiens

<400>  1393
gtctacttat caataagcag ctgcctgtgc agagtgcagg ctgcaccttt ggacagcctt     60

taaaactgaa ttctcagaat tttagaacaa atttttgtct agaaatgctg actttggttc    120

attaggtagt ggtaaaacag gctcccttcg aagctctcct tcatcacctt cctaagtgca    180

tgtacaggga agctctcctt catcaccttc ctaagtgcat gggggaaaat acctagggct    240

caacagtctt gagaagtgtg gaaacatttt ctttgtgagt gagaacagat cacctagaga    300

aaggaaacca gattcccatc actgcttctg ggtatcagat gctagcgctg cactccattt    360

tgcaatggcc tcccttgctg cagcaaatgc agagttttgc ttcaacctgt tcagagagat    420

ggatgacaat caaggaaatg gaaatgtgtt cttttcctct ctgagcctct tcgctgccct    480

ggccctggtc cgcttgggcg ctcaagatga ctccctctct cagattgata agttgcttca    540

tgttaacact gcctcaggat atggaaactc ttctaatagt cagtcagggc tccagtctca    600

actgaaaaga gttttttctg atataaatgc atcccacaag gattatgatc tcagcattgt    660

gaatgggctt tttgctgaaa aagtgtatgg ctttcataag gactacattg agtgtgccga    720

aaaattatac gatgccaaag tggagcgagt tgactttacg aatcatttag aagacactag    780

acgtaatatt aataagtggg ttgaaaatga aacacatggc aaaatcaaga acgtgattgg    840

tgaaggtggc ataagctcat ctgctgtaat ggtgctggtg aatgctgtgt acttcaaagg    900

caagtggcaa tcagccttca ccaagagcga aaccataaat tgccatttca aatctcccaa    960

gtgctctggg aaggcagtcg ccatgatgca tcaggaacgg aagttcaatt tgtctgttat   1020

tgaggaccca tcaatgaaga ttcttgagct cagatacaat ggtggcataa acatgtacgt   1080

tctgctgcct gagaatgacc tctctgaaat tgaaaacaaa ctgacctttc agaatctaat   1140

ggaatggacc aatccaaggc gaatgacctc taagtatgtt gaggtatttt ttcctcagtt   1200

caagatagag aagaattatg aaatgaaaca atatttgaga gccctagggc tgaaagatat   1260

ctttgatgaa tccaaagcag atctctctgg gattgcttcg gggggtcgtc tgtatatatc   1320

aaggatgatg cacaaatctt acatagaggt cactgaggag ggcaccgagg ctactgctgc   1380

cacaggaagt aatattgtag aaaagcaact ccctcagtcc acgctgttta gagctgacca   1440

cccattccta tttgttatca ggaaggatga catcatctta ttcagtggca aagtttcttg   1500

cccttgaaaa tccaattggt ttctgttata gcagtcccca caacatcaaa graccaccac   1560

aagtcaatag atytgrgttt aattggaaaa atgtggtgtt tcctttgagt ttatttcttc   1620

ctaacattgg tcagcagatg acactggtga cttgaccctt cctagacacc tggttgattg   1680

tcctgatccc tgctcttagc attctaccac catgtgtctc acccatttct aatttcattg   1740

tctttcttcc cacgctcatt tctatcattc tcccccatga cccgtctgga aattatggag   1800

rgtgctcaac tggtaaggag aacgtagaag tagccctagg gatccttttt gaaactctac   1860

agttatcgca gatattctag cttcattgta agcaatctag gaaataagcc ctgctgcttt   1920

ctagaaataa gtgtgaagga taaattttct ttgttgacct atgaagattt tagagtttac   1980

cttcatatgt ttgattttaa atcagtgtat aatctagatg gtaaaaaatg tgaaattggg   2040

attagggacc taccaaaata tttcattaat gctttcaatt gacaaatttt ggcctttctt   2100

tgataagaca atatgtacat gttttttcaa atattaaaga tcttttaact gttggcagtt   2160

gttatctaca gaatcatatt tcatatgctg tgtagtttat aagtttttcc tctatttatc   2220

agaataaaga aatacaacat acctgtaaa                                     2249


<210>  1394
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  1394

Met Ala Ser Leu Ala Ala Ala Asn Ala Glu Phe Cys Phe Asn Leu Phe 
1               5                   10                  15      


Arg Glu Met Asp Asp Asn Gln Gly Asn Gly Asn Val Phe Phe Ser Ser 
            20                  25                  30          


Leu Ser Leu Phe Ala Ala Leu Ala Leu Val Arg Leu Gly Ala Gln Asp 
        35                  40                  45              


Asp Ser Leu Ser Gln Ile Asp Lys Leu Leu His Val Asn Thr Ala Ser 
    50                  55                  60                  


Gly Tyr Gly Asn Ser Ser Asn Ser Gln Ser Gly Leu Gln Ser Gln Leu 
65                  70                  75                  80  


Lys Arg Val Phe Ser Asp Ile Asn Ala Ser His Lys Asp Tyr Asp Leu 
                85                  90                  95      


Ser Ile Val Asn Gly Leu Phe Ala Glu Lys Val Tyr Gly Phe His Lys 
            100                 105                 110         


Asp Tyr Ile Glu Cys Ala Glu Lys Leu Tyr Asp Ala Lys Val Glu Arg 
        115                 120                 125             


Val Asp Phe Thr Asn His Leu Glu Asp Thr Arg Arg Asn Ile Asn Lys 
    130                 135                 140                 


Trp Val Glu Asn Glu Thr His Gly Lys Ile Lys Asn Val Ile Gly Glu 
145                 150                 155                 160 


Gly Gly Ile Ser Ser Ser Ala Val Met Val Leu Val Asn Ala Val Tyr 
                165                 170                 175     


Phe Lys Gly Lys Trp Gln Ser Ala Phe Thr Lys Ser Glu Thr Ile Asn 
            180                 185                 190         


Cys His Phe Lys Ser Pro Lys Cys Ser Gly Lys Ala Val Ala Met Met 
        195                 200                 205             


His Gln Glu Arg Lys Phe Asn Leu Ser Val Ile Glu Asp Pro Ser Met 
    210                 215                 220                 


Lys Ile Leu Glu Leu Arg Tyr Asn Gly Gly Ile Asn Met Tyr Val Leu 
225                 230                 235                 240 


Leu Pro Glu Asn Asp Leu Ser Glu Ile Glu Asn Lys Leu Thr Phe Gln 
                245                 250                 255     


Asn Leu Met Glu Trp Thr Asn Pro Arg Arg Met Thr Ser Lys Tyr Val 
            260                 265                 270         


Glu Val Phe Phe Pro Gln Phe Lys Ile Glu Lys Asn Tyr Glu Met Lys 
        275                 280                 285             


Gln Tyr Leu Arg Ala Leu Gly Leu Lys Asp Ile Phe Asp Glu Ser Lys 
    290                 295                 300                 


Ala Asp Leu Ser Gly Ile Ala Ser Gly Gly Arg Leu Tyr Ile Ser Arg 
305                 310                 315                 320 


Met Met His Lys Ser Tyr Ile Glu Val Thr Glu Glu Gly Thr Glu Ala 
                325                 330                 335     


Thr Ala Ala Thr Gly Ser Asn Ile Val Glu Lys Gln Leu Pro Gln Ser 
            340                 345                 350         


Thr Leu Phe Arg Ala Asp His Pro Phe Leu Phe Val Ile Arg Lys Asp 
        355                 360                 365             


Asp Ile Ile Leu Phe Ser Gly Lys Val Ser Cys Pro 
    370                 375                 380 


<210>  1395
<211>  1900
<212>  DNA
<213>  Homosapiens

<400>  1395
acaactctca gaggagcatt gcccgtcaga cagcaactca gagaataacc agagaacaac     60

cagattgaaa caatggagga tctttgtgtg gcaaacacac tctttgccct caatttattc    120

aagcatctgg caaaagcaag ccccacccag aacctcttcc tctccccatg gagcatctcg    180

tccaccatgg ccatggtcta catgggctcc aggggcagca ccgaagacca gatggccaag    240

gtgcttcagt ttaatgaagt gggagccaat gcagttaccc ccatgactcc agagaacttt    300

accagctgtg ggttcatgca gcagatccag aagggtagtt atcctgatgc gattttgcag    360

gcacaagctg cagataaaat ccattcatcc ttccgctctc tcagctctgc aatcaatgca    420

tccacaggga attatttact ggaaagtgtc aataagctgt ttggtgagaa gtctgcgagc    480

ttccgggaag aatatattcg actctgtcag aaatattact cctcagaacc ccaggcagta    540

gacttcctag aatgtgcaga agaagctaga aaaaagatta attcctgggt caagactcaa    600

accaaaggca aaatcccaaa cttgttacct gaaggttctg tagatgggga taccaggatg    660

gtcctggtga atgctgtcta cttcaaagga aagtggaaaa ctccatttga gaagaaacta    720

aatgggcttt atcctttccg tgtaaactcg gctcagcgca cacctgtaca gatgatgtac    780

ttgcgtgaaa agctaaacat tggatacata gaagacctaa aggctcagat tctagaactc    840

ccatatgctg gagatgttag catgttcttg ttgcttccag atgaaattgc cgatgtgtcc    900

actggcttgg agctgctgga aagtgaaata acctatgaca aactcaacaa gtggaccagc    960

aaagacaaaa tggctgaaga tgaagttgag gtatacatac cccagttcaa attagaagag   1020

cattatgaac tcagatccat tctgagaagc atgggcatgg aggacgcctt caacaaggga   1080

cgggccaatt tctcagggat gtcggagagg aatgacctgt ttctttctga agtgttccac   1140

caagccatgg tggatgtgaa tgaggagggc actgaagcag ccgctggcac aggaggtgtt   1200

atgacaggga gaactggaca tggaggccca cagtttgtgg cagatcatcc ttttcttttt   1260

cttattatgc ataagataac caactgcatt ttatttttcg gcagattttc ctcaccctaa   1320

aactaagcgt gctgcttctg caaaagattt ttgtagatga gctgtgtgcc tcagaattgc   1380

tatttcaaat tgccaaaaat ttagagatgt tttctacata tttctgctct tctgaacaac   1440

ttctgctacc cactaaataa aaacacagaa ataattagac aattgtctat tataacatga   1500

caaccctatt aatcatttgg tcttctaaaa tgggatcatg cccatttaga ttttccttac   1560

tatcagttta tttttataac attaactttt actttgttat ttattatttt atataatggt   1620

gagtttttaa attattgctc actgcctatt taatgtagct aataaagtta tagaagcaga   1680

tgatctgtta atttcctatc taataaatgc ctttaattgt tctcataatg aagaataagt   1740

aggtaccctc catgcccttc tgtaataaat atctggaaaa aacattaaac aataggcaaa   1800

tatatgttat gtgcatttct agaaatacat aacacatata tatgtctgta tcttatattc   1860

aattgcaagt atataataaa taaacctgct tccaaacaac                         1900


<210>  1396
<211>  415
<212>  PRT
<213>  Homosapiens

<400>  1396

Met Glu Asp Leu Cys Val Ala Asn Thr Leu Phe Ala Leu Asn Leu Phe 
1               5                   10                  15      


Lys His Leu Ala Lys Ala Ser Pro Thr Gln Asn Leu Phe Leu Ser Pro 
            20                  25                  30          


Trp Ser Ile Ser Ser Thr Met Ala Met Val Tyr Met Gly Ser Arg Gly 
        35                  40                  45              


Ser Thr Glu Asp Gln Met Ala Lys Val Leu Gln Phe Asn Glu Val Gly 
    50                  55                  60                  


Ala Asn Ala Val Thr Pro Met Thr Pro Glu Asn Phe Thr Ser Cys Gly 
65                  70                  75                  80  


Phe Met Gln Gln Ile Gln Lys Gly Ser Tyr Pro Asp Ala Ile Leu Gln 
                85                  90                  95      


Ala Gln Ala Ala Asp Lys Ile His Ser Ser Phe Arg Ser Leu Ser Ser 
            100                 105                 110         


Ala Ile Asn Ala Ser Thr Gly Asn Tyr Leu Leu Glu Ser Val Asn Lys 
        115                 120                 125             


Leu Phe Gly Glu Lys Ser Ala Ser Phe Arg Glu Glu Tyr Ile Arg Leu 
    130                 135                 140                 


Cys Gln Lys Tyr Tyr Ser Ser Glu Pro Gln Ala Val Asp Phe Leu Glu 
145                 150                 155                 160 


Cys Ala Glu Glu Ala Arg Lys Lys Ile Asn Ser Trp Val Lys Thr Gln 
                165                 170                 175     


Thr Lys Gly Lys Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp Gly 
            180                 185                 190         


Asp Thr Arg Met Val Leu Val Asn Ala Val Tyr Phe Lys Gly Lys Trp 
        195                 200                 205             


Lys Thr Pro Phe Glu Lys Lys Leu Asn Gly Leu Tyr Pro Phe Arg Val 
    210                 215                 220                 


Asn Ser Ala Gln Arg Thr Pro Val Gln Met Met Tyr Leu Arg Glu Lys 
225                 230                 235                 240 


Leu Asn Ile Gly Tyr Ile Glu Asp Leu Lys Ala Gln Ile Leu Glu Leu 
                245                 250                 255     


Pro Tyr Ala Gly Asp Val Ser Met Phe Leu Leu Leu Pro Asp Glu Ile 
            260                 265                 270         


Ala Asp Val Ser Thr Gly Leu Glu Leu Leu Glu Ser Glu Ile Thr Tyr 
        275                 280                 285             


Asp Lys Leu Asn Lys Trp Thr Ser Lys Asp Lys Met Ala Glu Asp Glu 
    290                 295                 300                 


Val Glu Val Tyr Ile Pro Gln Phe Lys Leu Glu Glu His Tyr Glu Leu 
305                 310                 315                 320 


Arg Ser Ile Leu Arg Ser Met Gly Met Glu Asp Ala Phe Asn Lys Gly 
                325                 330                 335     


Arg Ala Asn Phe Ser Gly Met Ser Glu Arg Asn Asp Leu Phe Leu Ser 
            340                 345                 350         


Glu Val Phe His Gln Ala Met Val Asp Val Asn Glu Glu Gly Thr Glu 
        355                 360                 365             


Ala Ala Ala Gly Thr Gly Gly Val Met Thr Gly Arg Thr Gly His Gly 
    370                 375                 380                 


Gly Pro Gln Phe Val Ala Asp His Pro Phe Leu Phe Leu Ile Met His 
385                 390                 395                 400 


Lys Ile Thr Asn Cys Ile Leu Phe Phe Gly Arg Phe Ser Ser Pro 
                405                 410                 415 


<210>  1397
<211>  1194
<212>  DNA
<213>  Homosapiens

<400>  1397
atggactctc tagcaacatc aatcaaccag tttgccctgg agttgagcaa aaagctagct     60

gaatctgctc agggtaaaaa tatcttcttt tcttcctgga gcatctcaac ttccttgacc    120

atagtgtatt tgggcgccaa aggtaccact gcagcccaaa tggcccaggt gcttcaattt    180

aacagagacc agggagtcaa atgtgaccct gaaagtgaaa aaaaaaggaa aatggaattc    240

aacttgagca actcggaaga aatacactct gatttccaaa cacttatctc agaaatcctc    300

aagcccaacg atgactactt acttaaaaca gccaatgcga tatatggaga gaaaacgtat    360

gcatttcaca ataaatattt agaagacatg aaaacatatt ttggtgcaga acctcagcct    420

gttaactttg tggaagcttc tgatcaaatc agaaaggaca tcaactcttg ggttgaaaga    480

cagaccgagg gtaaaatcca gaatctcctg cctgatgact ctgtggattc cacaaccagg    540

atgattctgg tgaacgccct atactttaaa ggaatctggg aacatcaatt cttagtgcaa    600

aacaccacag aaaagccttt tagaataaac gagactacaa gcaaaccagt gcaaatgatg    660

tttatgaaga aaaagcttca catttttcac atagaaaagc caaaagcagt gggccttcaa    720

ctctactaca aaagccgtga cctcagcctg cttatactac tgccagaaga cattaatggg    780

ctggaacagc tggaaaaggc catcacctat gagaagctga atgagtggac cagtgcagac    840

atgatggagt tgtatgaagt gcagctacac cttcccaagt tcaagctgga agacagttat    900

gatctcaagt caaccctgag cagtatgggg atgagtgatg ccttcagcca aagcaaagct    960

gatttctcag gaatgtcttc agcaagaaac ctatttttgt ccaatgtttt ccataaggct   1020

tttgtggaaa taaatgaaca aggtactgaa gctgcagctg gcagtgggag tgagatagat   1080

atacgaatta gagtcccatc cattgaattc aatgcaaatc acccattcct cttcttcatc   1140

aggcacaata aaaccaacac cattcttttt tatggaagat tatgctcccc ctaa         1194


<210>  1398
<211>  397
<212>  PRT
<213>  Homosapiens

<400>  1398

Met Asp Ser Leu Ala Thr Ser Ile Asn Gln Phe Ala Leu Glu Leu Ser 
1               5                   10                  15      


Lys Lys Leu Ala Glu Ser Ala Gln Gly Lys Asn Ile Phe Phe Ser Ser 
            20                  25                  30          


Trp Ser Ile Ser Thr Ser Leu Thr Ile Val Tyr Leu Gly Ala Lys Gly 
        35                  40                  45              


Thr Thr Ala Ala Gln Met Ala Gln Val Leu Gln Phe Asn Arg Asp Gln 
    50                  55                  60                  


Gly Val Lys Cys Asp Pro Glu Ser Glu Lys Lys Arg Lys Met Glu Phe 
65                  70                  75                  80  


Asn Leu Ser Asn Ser Glu Glu Ile His Ser Asp Phe Gln Thr Leu Ile 
                85                  90                  95      


Ser Glu Ile Leu Lys Pro Asn Asp Asp Tyr Leu Leu Lys Thr Ala Asn 
            100                 105                 110         


Ala Ile Tyr Gly Glu Lys Thr Tyr Ala Phe His Asn Lys Tyr Leu Glu 
        115                 120                 125             


Asp Met Lys Thr Tyr Phe Gly Ala Glu Pro Gln Pro Val Asn Phe Val 
    130                 135                 140                 


Glu Ala Ser Asp Gln Ile Arg Lys Asp Ile Asn Ser Trp Val Glu Arg 
145                 150                 155                 160 


Gln Thr Glu Gly Lys Ile Gln Asn Leu Leu Pro Asp Asp Ser Val Asp 
                165                 170                 175     


Ser Thr Thr Arg Met Ile Leu Val Asn Ala Leu Tyr Phe Lys Gly Ile 
            180                 185                 190         


Trp Glu His Gln Phe Leu Val Gln Asn Thr Thr Glu Lys Pro Phe Arg 
        195                 200                 205             


Ile Asn Glu Thr Thr Ser Lys Pro Val Gln Met Met Phe Met Lys Lys 
    210                 215                 220                 


Lys Leu His Ile Phe His Ile Glu Lys Pro Lys Ala Val Gly Leu Gln 
225                 230                 235                 240 


Leu Tyr Tyr Lys Ser Arg Asp Leu Ser Leu Leu Ile Leu Leu Pro Glu 
                245                 250                 255     


Asp Ile Asn Gly Leu Glu Gln Leu Glu Lys Ala Ile Thr Tyr Glu Lys 
            260                 265                 270         


Leu Asn Glu Trp Thr Ser Ala Asp Met Met Glu Leu Tyr Glu Val Gln 
        275                 280                 285             


Leu His Leu Pro Lys Phe Lys Leu Glu Asp Ser Tyr Asp Leu Lys Ser 
    290                 295                 300                 


Thr Leu Ser Ser Met Gly Met Ser Asp Ala Phe Ser Gln Ser Lys Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Met Ser Ser Ala Arg Asn Leu Phe Leu Ser Asn Val 
                325                 330                 335     


Phe His Lys Ala Phe Val Glu Ile Asn Glu Gln Gly Thr Glu Ala Ala 
            340                 345                 350         


Ala Gly Ser Gly Ser Glu Ile Asp Ile Arg Ile Arg Val Pro Ser Ile 
        355                 360                 365             


Glu Phe Asn Ala Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys 
    370                 375                 380                 


Thr Asn Thr Ile Leu Phe Tyr Gly Arg Leu Cys Ser Pro 
385                 390                 395         


<210>  1399
<211>  618
<212>  DNA
<213>  Homosapiens

<400>  1399
ccgacccggt ctcacttcgc tcctgggcag ctgcgcggag aactggggct caccgtcatg     60

gatgctctat cagaagcaaa tggcacattt gcattaaacc ttttgaaaaa gctaggggaa    120

aacaactcaa acaacttatt tttttcccca tgagcatatc atcagccttg gccatggttt    180

tcatgggggc aaagggaaac actgcagctc agatgtctca ggcactttgt tttagtaaaa    240

tcggaggtga agatggagat attcatcgag gttttcagtc acttcttgtt gcaattaaca    300

gaactgacac tgaatatgtg cttagaactg ccaacgggct ctttggagaa aagtcttatg    360

atttcctcac aggttttaca gattcctgtg gcaaattcta ccaagcaacg ataaaacagc    420

tagactttgt gaatgataca gagaagtcca caacacgtgt aaactcctgg gttgctgata    480

aaactaaagg tgaaaatata ttgttattct atttcgataa tattttaaac agttttatag    540

tcagttcttt acaaaactgt caaatataaa aaggagtcct tttttctcta aacaactatg    600

caaacattaa aacctttc                                                  618


<210>  1400
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  1400

Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly 
1               5                   10                  15      


Asn Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Phe Ser Lys Ile Gly 
            20                  25                  30          


Gly Glu Asp Gly Asp Ile His Arg Gly Phe Gln Ser Leu Leu Val Ala 
        35                  40                  45              


Ile Asn Arg Thr Asp Thr Glu Tyr Val Leu Arg Thr Ala Asn Gly Leu 
    50                  55                  60                  


Phe Gly Glu Lys Ser Tyr Asp Phe Leu Thr Gly Phe Thr Asp Ser Cys 
65                  70                  75                  80  


Gly Lys Phe Tyr Gln Ala Thr Ile Lys Gln Leu Asp Phe Val Asn Asp 
                85                  90                  95      


Thr Glu Lys Ser Thr Thr Arg Val Asn Ser Trp Val Ala Asp Lys Thr 
            100                 105                 110         


Lys Gly Glu Asn Ile Leu Leu Phe Tyr Phe Asp Asn Ile Leu Asn Ser 
        115                 120                 125             


Phe Ile Val Ser Ser Leu Gln Asn Cys Gln Ile 
    130                 135                 


<210>  1401
<211>  3390
<212>  DNA
<213>  Homosapiens

<400>  1401
caagccagag caatcgaacg gttctgagtc atctgccgga agccttgccc tcaatcaagg     60

cggacgtgaa gcatctacaa aggaggaata gtcaaagcag cagcggcggc ggcggcggcg    120

gcagcagcag cagcagcagg agaccttctc tgatggatga cctctgtgaa gcaaatggca    180

cttttgccat cagcttattt aaaatattgg gggaagagga caactcaaga aacgtattct    240

tctctcccat gagcatctcc tctgccctgg ccatggtctt catgggggca aagggaagca    300

ctgcagccca gatgtcccag gcactttgtt tatacaaaga cggagatatt caccgaggtt    360

tccagtcact tctcagtgaa gttaacagaa ctggcactca gtacttgctt agaactgcca    420

acagactctt tggagaaaag acgtgtgatt tccttccaga ctttaaagaa tactgtcaga    480

agttctatca ggcagagctg gaggagttgt cctttgctga agacactgaa gagtgcagga    540

agcatataaa tgactgggtg gcagagaaga ctgaaggtaa gatttcagag gtactggatg    600

ctgggacagt cgatcccctg acaaagctgg tccttgtgaa tgccatttat ttcaagggaa    660

agtggaatga gcaatttgac agaaagtaca caaggggaat gctctttaaa accaacgagg    720

aaaaaaagac agtgcagatg atgtttaagg aagctaagtt taaaatgggg tatgcggatg    780

aggtacacac ccaggtcctg gagctgccct atgtggaaga ggagctgagc atggtcattc    840

tgcttcccga tgacaacacg gacctcgccg tggtggaaaa agcacttaca tatgagaaat    900

tcaaagcctg gacaaattca gaaaagttga caaaaagtaa ggttcaagtt ttccttccca    960

gattaaagct ggaggagagt tatgacttgg agcctttcct tcgaagatta ggaatgatcg   1020

atgcttttga cgaagccaag gcagactttt ctggaatgtc aactgagaag aatgtgcctc   1080

tgtccaaggt tgcccacaag tgcttcgtgg aggtcaatga ggaaggcaca gaggctgccg   1140

cagccactgc tgtggtcagg aattcccggt gcagcagaat ggagccaaga ttctgtgcag   1200

accacccttt tcttttcttc atcaggcacc acaaaaccaa ctgcatcttg ttctgtggca   1260

ggttctcttc tccgtaaaga ggagcaattg ctgtacatac cctcctttcc ttctacctat   1320

cttgccttaa ttaacattcc ctgtgaccta gttggtgcag tggcttgaat gccaaaataa   1380

agcgtgtgca ctggatagtg tgtgaaagtc tttgctgaaa gttccagagc cattgagaat   1440

aactgaggcc gcagatgcat gaaatttggg cctgggaagg ctatgctggt tttggagtgt   1500

ttggggtgcc tgccattgcc tctgccttca cctaagtctg tgcccattgt ttcaggggat   1560

cttatggagc atctcagggc ttcaggagcc agccctcttc catccgcccg gctctgccca   1620

ccaccactgc caggctgaac aggggactag tgcccaggtg acactgcaca caaagccaag   1680

ggcaaaccct atagagtaaa gctgcagcca ccctgtgtct catgtgcagc tgaaatagtg   1740

atctgcttct gtcactgtca catagacagc cctgcatgcc ccctgtctca cacagtttgt   1800

aatgaagaca gctccttctc atctttccat aagcctgaga tacaagttca gggactcagc   1860

aatgcacttt aggactgagc taggaggcaa atatctgaag cttgctatgc tgttctttcc   1920

attccttttc cctctgaaac acacaaaata ccaaaggaac ttacgcaaca caccactgag   1980

tcctctaact aatcatatgt gctcagacac agctcaagca caccccttag ttaagaaaga   2040

acctccatat acattaattt ttttctgcct aaaaataaaa ttgcgttgtg gcagcaattt   2100

ggaaactaca gcaaagtctc caaaaaaatt gaagtcaccc acaattccaa cacacagcaa   2160

tcactgctgt taatagtgat atacatcctt ccctattatg tgtatgcaaa tagaaattta   2220

taagcatttt actacaagtt aatcatatcc ttcagtagct tatttcttcc cttatgaaaa   2280

acctccctta agatctttcc aggtcatcaa tttgatgtgc atagtattcc actgtgtggc   2340

tggatttcta taattgaatc taattttaga cagtttgagt aattaaaatt atttctatta   2400

acaaataata gattgctaat aatatatatt atgctgtttt ggatatacta aatatttgct   2460

cacatcctta atatattttt taaaattcct aacaatagta ctgttgagat aaaagttgag   2520

cacattttga gacttcttcc aaattggtcc ctagaaagtt acactggttt gtactctcac   2580

ttatgtcact gtttatacca ccactgactg ctgcctgctt tattatttct ttaatgagtt   2640

ggactgaaca gtggttaatc ctgactctgt ttttgactga cagttaacag ttacatgaac   2700

cattcatatt acagctctta cttaaatttg accaagccag gatatatctg ttaggccaca   2760

ttcatttagg gatcatgttt tccaaagcag gtttgggcaa aattaatcca caggactgaa   2820

aggtatacat ctgtgagttt tgttctcact tccacctcta atttgaagaa cactttaatt   2880

gacacagaat acatttcaca tatttaacct ctacaataag ttctgacaca ttttccatga   2940

aacaaaccat cgctatattc aagataatga acctatctat catactccca aattccttct   3000

tgcatctttg taatttctca ctcttccttc tccctctccc cgtcccatcc caaccactga   3060

tctgctcagg caactaccaa tcttctttct gtcactatag attaatttgc atttttaaag   3120

aaatttacat acatggaacc atacatcatc tatgctttgt agtatgactc ctgtcactca   3180

gtacaattat tttgagattc atttatgtta ttgtatgtat caatagttca tcccttttat   3240

tggtaagtaa catttttttg tataggtata ccatgatttg ttgatgaaca aatttacctg   3300

ttgatgaaca tttacgttgt taccaagatt tttgctattg aaaataaagt ttttatgaat   3360

atttatatat ataaaaaaaa aaaaaaaaaa                                    3390


<210>  1402
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  1402

Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe 
1               5                   10                  15      


Lys Ile Leu Gly Glu Glu Asp Asn Ser Arg Asn Val Phe Phe Ser Pro 
            20                  25                  30          


Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly 
        35                  40                  45              


Ser Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Leu Tyr Lys Asp Gly 
    50                  55                  60                  


Asp Ile His Arg Gly Phe Gln Ser Leu Leu Ser Glu Val Asn Arg Thr 
65                  70                  75                  80  


Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                85                  90                  95      


Thr Cys Asp Phe Leu Pro Asp Phe Lys Glu Tyr Cys Gln Lys Phe Tyr 
            100                 105                 110         


Gln Ala Glu Leu Glu Glu Leu Ser Phe Ala Glu Asp Thr Glu Glu Cys 
        115                 120                 125             


Arg Lys His Ile Asn Asp Trp Val Ala Glu Lys Thr Glu Gly Lys Ile 
    130                 135                 140                 


Ser Glu Val Leu Asp Ala Gly Thr Val Asp Pro Leu Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Gln Phe Asp 
                165                 170                 175     


Arg Lys Tyr Thr Arg Gly Met Leu Phe Lys Thr Asn Glu Glu Lys Lys 
            180                 185                 190         


Thr Val Gln Met Met Phe Lys Glu Ala Lys Phe Lys Met Gly Tyr Ala 
        195                 200                 205             


Asp Glu Val His Thr Gln Val Leu Glu Leu Pro Tyr Val Glu Glu Glu 
    210                 215                 220                 


Leu Ser Met Val Ile Leu Leu Pro Asp Asp Asn Thr Asp Leu Ala Val 
225                 230                 235                 240 


Val Glu Lys Ala Leu Thr Tyr Glu Lys Phe Lys Ala Trp Thr Asn Ser 
                245                 250                 255     


Glu Lys Leu Thr Lys Ser Lys Val Gln Val Phe Leu Pro Arg Leu Lys 
            260                 265                 270         


Leu Glu Glu Ser Tyr Asp Leu Glu Pro Phe Leu Arg Arg Leu Gly Met 
        275                 280                 285             


Ile Asp Ala Phe Asp Glu Ala Lys Ala Asp Phe Ser Gly Met Ser Thr 
    290                 295                 300                 


Glu Lys Asn Val Pro Leu Ser Lys Val Ala His Lys Cys Phe Val Glu 
305                 310                 315                 320 


Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Val Val Arg 
                325                 330                 335     


Asn Ser Arg Cys Ser Arg Met Glu Pro Arg Phe Cys Ala Asp His Pro 
            340                 345                 350         


Phe Leu Phe Phe Ile Arg His His Lys Thr Asn Cys Ile Leu Phe Cys 
        355                 360                 365             


Gly Arg Phe Ser Ser Pro 
    370                 


<210>  1403
<211>  1409
<212>  DNA
<213>  Homosapiens

<400>  1403
caagccagag caatcgaacg gttctgagtc atctgccgga agccttgccc tcaatcaagg     60

cggacgtgaa gcatctacaa aggaggaata gtcaaagcag cagcggcggc ggcggcggcg    120

gcagcagcag cagcagcagg agaccttctc tgatggatga cctctgtgaa gcaaatggca    180

cttttgccat cagcttattt aaaatattgg gggaagagga caactcaaga aacgtattct    240

tctctcccat gagcatctcc tctgccctgg ccatggtctt catgggggca aagggaagca    300

ctgcagccca gatgtcccag gcactttgtt tatacaaaga cggagatatt caccgaggtt    360

tccagtcact tctcagtgaa gttaacagaa ctggcactca gtacttgctt agaactgcca    420

acagactctt tggagaaaag acgtgtgatt tccttccaga ctttaaagaa tactgtcaga    480

agttctatca ggcagagctg gaggagttgt cctttgctga agacactgaa gagtgcagga    540

agcatataaa tgactgggtg gcagagaaga ctgaaggtaa gatttcagag gtactggatg    600

ctgggacagt cgatcccctg acaaagctgg tccttgtgaa tgccatttat ttcaagggaa    660

agtggaatga gcaatttgac agaaagtaca caaggggaat gctctttaaa accaacgagg    720

aaaaaaagac agtgcagatg atgtttaagg aagctaagtt taaaatgggg tatgcggatg    780

aggtacacac ccaggtcctg gagctgccct atgtggaaga ggagctgagc atggtcattc    840

tgcttcccga tgacaacacg gacctcgccg tgaaagagtg atggatcttg aagaatttga    900

agctaactcc aggacaggca gaggacaaac aaggatgctg atgaagtctt cttgcattcc    960

ccatttctcg tctcatgctc ccttctcatg cctcccttca tcttcagatg aaacacaatt   1020

ccctctcttt tactctgagt tgccctctga tttaaccctg aatagtcccc tcattagact   1080

cagaagcaga gttctgagcc atgctctttg tcttttgtca aacaatctct cccactcaca   1140

gtagtatgta ttgcatgaag attaatgtaa tgaattggtt agaattttct aaactgttaa   1200

aaaatgtttt taacatttga aaggagttag gtacaaattg tttttattaa aaatttctgc   1260

ctgtctcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     1409


<210>  1404
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  1404

Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe 
1               5                   10                  15      


Lys Ile Leu Gly Glu Glu Asp Asn Ser Arg Asn Val Phe Phe Ser Pro 
            20                  25                  30          


Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly 
        35                  40                  45              


Ser Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Leu Tyr Lys Asp Gly 
    50                  55                  60                  


Asp Ile His Arg Gly Phe Gln Ser Leu Leu Ser Glu Val Asn Arg Thr 
65                  70                  75                  80  


Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                85                  90                  95      


Thr Cys Asp Phe Leu Pro Asp Phe Lys Glu Tyr Cys Gln Lys Phe Tyr 
            100                 105                 110         


Gln Ala Glu Leu Glu Glu Leu Ser Phe Ala Glu Asp Thr Glu Glu Cys 
        115                 120                 125             


Arg Lys His Ile Asn Asp Trp Val Ala Glu Lys Thr Glu Gly Lys Ile 
    130                 135                 140                 


Ser Glu Val Leu Asp Ala Gly Thr Val Asp Pro Leu Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Gln Phe Asp 
                165                 170                 175     


Arg Lys Tyr Thr Arg Gly Met Leu Phe Lys Thr Asn Glu Glu Lys Lys 
            180                 185                 190         


Thr Val Gln Met Met Phe Lys Glu Ala Lys Phe Lys Met Gly Tyr Ala 
        195                 200                 205             


Asp Glu Val His Thr Gln Val Leu Glu Leu Pro Tyr Val Glu Glu Glu 
    210                 215                 220                 


Leu Ser Met Val Ile Leu Leu Pro Asp Asp Asn Thr Asp Leu Ala Val 
225                 230                 235                 240 


Lys Glu 
        


<210>  1405
<211>  3407
<212>  DNA
<213>  Homosapiens

<400>  1405
caagccagag caatcgaacg gttctgagtc atctgccgga agccttgccc tcaatcaagg     60

cggacgtgaa gcatctacaa aggaggaata gtcaaagcag cagcggcggc ggcggcggcg    120

gcagcagcag cagcagcagg aggtgggggc ctctgccaga ccttctctga tggatgacct    180

ctgtgaagca aatggcactt ttgccatcag cttatttaaa atattggggg aagaggacaa    240

ctcaagaaac gtattcttct ctcccatgag catctcctct gccctggcca tggtcttcat    300

gggggcaaag ggaagcactg cagcccagat gtcccaggca ctttgtttat acaaagacgg    360

agatattcac cgaggtttcc agtcacttct cagtgaagtt aacagaactg gcactcagta    420

cttgcttaga actgccaaca gactctttgg agaaaagacg tgtgatttcc ttccagactt    480

taaagaatac tgtcagaagt tctatcaggc agagctggag gagttgtcct ttgctgaaga    540

cactgaagag tgcaggaagc atataaatga ctgggtggca gagaagactg aaggtaagat    600

ttcagaggta ctggatgctg ggacagtcga tcccctgaca aagctggtcc ttgtgaatgc    660

catttatttc aagggaaagt ggaatgagca atttgacaga aagtacacaa ggggaatgct    720

ctttaaaacc aacgaggaaa aaaagacagt gcagatgatg tttaaggaag ctaagtttaa    780

aatggggtat gcggatgagg tacacaccca ggtcctggag ctgccctatg tggaagagga    840

gctgagcatg gtcattctgc ttcccgatga caacacggac ctcgccgtgg tggaaaaagc    900

acttacatat gagaaattca aagcctggac aaattcagaa aagttgacaa aaagtaaggt    960

tcaagttttc cttcccagat taaagctgga ggagagttat gacttggagc ctttccttcg   1020

aagattagga atgatcgatg cttttgacga agccaaggca gacttttctg gaatgtcaac   1080

tgagaagaat gtgcctctgt ccaaggttgc ccacaagtgc ttcgtggagg tcaatgagga   1140

aggcacagag gctgccgcag ccactgctgt ggtcaggaat tcccggtgca gcagaatgga   1200

gccaagattc tgtgcagacc acccttttct tttcttcatc aggcaccaca aaaccaactg   1260

catcttgttc tgtggcaggt tctcttctcc gtaaagagga gcaattgctg tacataccct   1320

cctttccttc tacctatctt gccttaatta acattccctg tgacctagtt ggtgcagtgg   1380

cttgaatgcc aaaataaagc gtgtgcactg gatagtgtgt gaaagtcttt gctgaaagtt   1440

ccagagccat tgagaataac tgaggccgca gatgcatgaa atttgggcct gggaaggcta   1500

tgctggtttt ggagtgtttg gggtgcctgc cattgcctct gccttcacct aagtctgtgc   1560

ccattgtttc aggggatctt atggagcatc tcagggcttc aggagccagc cctcttccat   1620

ccgcccggct ctgcccacca ccactgccag gctgaacagg ggactagtgc ccaggtgaca   1680

ctgcacacaa agccaagggc aaaccctata gagtaaagct gcagccaccc tgtgtctcat   1740

gtgcagctga aatagtgatc tgcttctgtc actgtcacat agacagccct gcatgccccc   1800

tgtctcacac agtttgtaat gaagacagct ccttctcatc tttccataag cctgagatac   1860

aagttcaggg actcagcaat gcactttagg actgagctag gaggcaaata tctgaagctt   1920

gctatgctgt tctttccatt ccttttccct ctgaaacaca caaaatacca aaggaactta   1980

cgcaacacac cactgagtcc tctaactaat catatgtgct cagacacagc tcaagcacac   2040

cccttagtta agaaagaacc tccatataca ttaatttttt tctgcctaaa aataaaattg   2100

cgttgtggca gcaatttgga aactacagca aagtctccaa aaaaattgaa gtcacccaca   2160

attccaacac acagcaatca ctgctgttaa tagtgatata catccttccc tattatgtgt   2220

atgcaaatag aaatttataa gcattttact acaagttaat catatccttc agtagcttat   2280

ttcttccctt atgaaaaacc tcccttaaga tctttccagg tcatcaattt gatgtgcata   2340

gtattccact gtgtggctgg atttctataa ttgaatctaa ttttagacag tttgagtaat   2400

taaaattatt tctattaaca aataatagat tgctaataat atatattatg ctgttttgga   2460

tatactaaat atttgctcac atccttaata tattttttaa aattcctaac aatagtactg   2520

ttgagataaa agttgagcac attttgagac ttcttccaaa ttggtcccta gaaagttaca   2580

ctggtttgta ctctcactta tgtcactgtt tataccacca ctgactgctg cctgctttat   2640

tatttcttta atgagttgga ctgaacagtg gttaatcctg actctgtttt tgactgacag   2700

ttaacagtta catgaaccat tcatattaca gctcttactt aaatttgacc aagccaggat   2760

atatctgtta ggccacattc atttagggat catgttttcc aaagcaggtt tgggcaaaat   2820

taatccacag gactgaaagg tatacatctg tgagttttgt tctcacttcc acctctaatt   2880

tgaagaacac tttaattgac acagaataca tttcacatat ttaacctcta caataagttc   2940

tgacacattt tccatgaaac aaaccatcgc tatattcaag ataatgaacc tatctatcat   3000

actcccaaat tccttcttgc atctttgtaa tttctcactc ttccttctcc ctctccccgt   3060

cccatcccaa ccactgatct gctcaggcaa ctaccaatct tctttctgtc actatagatt   3120

aatttgcatt tttaaagaaa tttacataca tggaaccata catcatctat gctttgtagt   3180

atgactcctg tcactcagta caattatttt gagattcatt tatgttattg tatgtatcaa   3240

tagttcatcc cttttattgg taagtaacat ttttttgtat aggtatacca tgatttgttg   3300

atgaacaaat ttacctgttg atgaacattt acgttgttac caagattttt gctattgaaa   3360

ataaagtttt tatgaatatt tatatatata aaaaaaaaaa aaaaaaa                 3407


<210>  1406
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  1406

Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe 
1               5                   10                  15      


Lys Ile Leu Gly Glu Glu Asp Asn Ser Arg Asn Val Phe Phe Ser Pro 
            20                  25                  30          


Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly 
        35                  40                  45              


Ser Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Leu Tyr Lys Asp Gly 
    50                  55                  60                  


Asp Ile His Arg Gly Phe Gln Ser Leu Leu Ser Glu Val Asn Arg Thr 
65                  70                  75                  80  


Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                85                  90                  95      


Thr Cys Asp Phe Leu Pro Asp Phe Lys Glu Tyr Cys Gln Lys Phe Tyr 
            100                 105                 110         


Gln Ala Glu Leu Glu Glu Leu Ser Phe Ala Glu Asp Thr Glu Glu Cys 
        115                 120                 125             


Arg Lys His Ile Asn Asp Trp Val Ala Glu Lys Thr Glu Gly Lys Ile 
    130                 135                 140                 


Ser Glu Val Leu Asp Ala Gly Thr Val Asp Pro Leu Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Gln Phe Asp 
                165                 170                 175     


Arg Lys Tyr Thr Arg Gly Met Leu Phe Lys Thr Asn Glu Glu Lys Lys 
            180                 185                 190         


Thr Val Gln Met Met Phe Lys Glu Ala Lys Phe Lys Met Gly Tyr Ala 
        195                 200                 205             


Asp Glu Val His Thr Gln Val Leu Glu Leu Pro Tyr Val Glu Glu Glu 
    210                 215                 220                 


Leu Ser Met Val Ile Leu Leu Pro Asp Asp Asn Thr Asp Leu Ala Val 
225                 230                 235                 240 


Val Glu Lys Ala Leu Thr Tyr Glu Lys Phe Lys Ala Trp Thr Asn Ser 
                245                 250                 255     


Glu Lys Leu Thr Lys Ser Lys Val Gln Val Phe Leu Pro Arg Leu Lys 
            260                 265                 270         


Leu Glu Glu Ser Tyr Asp Leu Glu Pro Phe Leu Arg Arg Leu Gly Met 
        275                 280                 285             


Ile Asp Ala Phe Asp Glu Ala Lys Ala Asp Phe Ser Gly Met Ser Thr 
    290                 295                 300                 


Glu Lys Asn Val Pro Leu Ser Lys Val Ala His Lys Cys Phe Val Glu 
305                 310                 315                 320 


Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Val Val Arg 
                325                 330                 335     


Asn Ser Arg Cys Ser Arg Met Glu Pro Arg Phe Cys Ala Asp His Pro 
            340                 345                 350         


Phe Leu Phe Phe Ile Arg His His Lys Thr Asn Cys Ile Leu Phe Cys 
        355                 360                 365             


Gly Arg Phe Ser Ser Pro 
    370                 


<210>  1407
<211>  889
<212>  DNA
<213>  Homosapiens

<400>  1407
agggaatgat ggactctgat ttccacaccc ctttcctgtg aacttgtctc caatttagtc     60

tgtcaaggtc cctttcttgt gagttaattt ctccctagtg ctacttctca gattggccag    120

tgactcacag agtggcacaa gtacaaatcc agcctgcctt gcatccaaca cagattccag    180

gaccactgaa accagctgag gcatcctgaa agcctaagat tgaccacacc agaggaacca    240

gactgccctt cacaaggatg gaaattatct ggttccaccc ctggatatga tcaaccttca    300

tagactgtgc attatacatg ccatctctgc gacctgcaaa gatgaaaagg gaaagcagga    360

gatggaaact ggtcagcagc cttctggttt atcagccaca cttacaaagg tcaaatgtgc    420

aaagcgtcag aagacagtgg ttagagtgag attctacatg ctctcaatga agaataaagc    480

atgcaggaag aacctttcaa aaggttacaa ccagagacct gaaggaagca aggaagaaag    540

ccacatggtt gtcaaagaga agaggaaagg agatcactaa gctggatgac gttttctgtt    600

tctttgaaaa cagagaagat gacaagttag ggagagatca gaggtcatac tgtgaagcac    660

ctttggataa acggcaggga ctttggattt tctttttgaa tataagcata atccattgaa    720

aggtctcatg cagggaagtg gcaaaacact tttaaaattt ttcatctttt ctttctgaag    780

cagagttcac tctccattta tttgtcttct ttgatatctc tcaatagaat gttgcagttt    840

tagtattctc ctattaaaca tttgtttaac tttaaaaaaa aaaaaaaaa                889


<210>  1408
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  1408

Met Ile Asn Leu His Arg Leu Cys Ile Ile His Ala Ile Ser Ala Thr 
1               5                   10                  15      


Cys Lys Asp Glu Lys Gly Lys Gln Glu Met Glu Thr Gly Gln Gln Pro 
            20                  25                  30          


Ser Gly Leu Ser Ala Thr Leu Thr Lys Val Lys Cys Ala Lys Arg Gln 
        35                  40                  45              


Lys Thr Val Val Arg Val Arg Phe Tyr Met Leu Ser Met Lys Asn Lys 
    50                  55                  60                  


Ala Cys Arg Lys Asn Leu Ser Lys Gly Tyr Asn Gln Arg Pro Glu Gly 
65                  70                  75                  80  


Ser Lys Glu Glu Ser His Met Val Val Lys Glu Lys Arg Lys Gly Asp 
                85                  90                  95      


His 
    


<210>  1409
<211>  930
<212>  DNA
<213>  Homosapiens

<400>  1409
atgatcaacc atcttttgct caacaacagt gccaagatgt ccatcctggg gccaggtacc     60

tggaagtctc ctccagacct ggtgaccgag tctgtaaatg tggtgattaa cattgggtac    120

tgccacatag attgtgccca cgtgtaccag aatgagaatg agtcaggggt ggccatttag    180

gagaagctca gggagcaggc agtaaagtgc aagtagctct tcatcatcag caatctgtgg    240

tgcacatgtc ttaagaaggg tctgctgaaa aaaacctgcc agaagatgct cagttacttg    300

aatctggact acctagacat ctaccttatt cactggacaa ctggctttaa gccagggaag    360

aaatttttcc cactggatga ttcagccatt gtatatccca atgacaccag cattgtggac    420

acatgagcag ccatgaaaga gctggtggat gaagggttgg tgaaagctat tggcatctcc    480

aagttcaact attctcatgt caggaggatc ttaaacaaac gtggcttaaa gtatcagcca    540

atggttaaag agattgagtt ctgcacatac ctaactcaaa agaagttaat ccagtactgc    600

cagtccaaag gcatcatggt gactgcctat agcccccttg actgtctgga caggccctgg    660

gcaaagctca aggattcttc tgtcctggag gatgccagaa gcaaggtgat cacagtcaaa    720

cataataaaa ctacagctca ggttctgatt tgatttccca ttcagagaaa cttggtggtg    780

aatcccaagt ctgtgacaca aaaatgcatt gcagagaact ttaaggcctt ttactttgaa    840

ctaagcagca aggatatgac caccttacct agctacaaca gaaactgtgc cttggtaagc    900

tgtacctcgc acaaggatta ccccttctag                                     930


<210>  1410
<211>  309
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  Xaa can be any naturally occurring amino acid

<400>  1410

Met Ile Asn His Leu Leu Leu Asn Asn Ser Ala Lys Met Ser Ile Leu 
1               5                   10                  15      


Gly Pro Gly Thr Trp Lys Ser Pro Pro Asp Leu Val Thr Glu Ser Val 
            20                  25                  30          


Asn Val Val Ile Asn Ile Gly Tyr Cys His Ile Asp Cys Ala His Val 
        35                  40                  45              


Tyr Gln Asn Glu Asn Glu Ser Gly Val Ala Ile Xaa Glu Lys Leu Arg 
    50                  55                  60                  


Glu Gln Ala Val Lys Cys Lys Xaa Leu Phe Ile Ile Ser Asn Leu Trp 
65                  70                  75                  80  


Cys Thr Cys Leu Lys Lys Gly Leu Leu Lys Lys Thr Cys Gln Lys Met 
                85                  90                  95      


Leu Ser Tyr Leu Asn Leu Asp Tyr Leu Asp Ile Tyr Leu Ile His Trp 
            100                 105                 110         


Thr Thr Gly Phe Lys Pro Gly Lys Lys Phe Phe Pro Leu Asp Asp Ser 
        115                 120                 125             


Ala Ile Val Tyr Pro Asn Asp Thr Ser Ile Val Asp Thr Xaa Ala Ala 
    130                 135                 140                 


Met Lys Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 
145                 150                 155                 160 


Lys Phe Asn Tyr Ser His Val Arg Arg Ile Leu Asn Lys Arg Gly Leu 
                165                 170                 175     


Lys Tyr Gln Pro Met Val Lys Glu Ile Glu Phe Cys Thr Tyr Leu Thr 
            180                 185                 190         


Gln Lys Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Met Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Asp Cys Leu Asp Arg Pro Trp Ala Lys Leu Lys 
    210                 215                 220                 


Asp Ser Ser Val Leu Glu Asp Ala Arg Ser Lys Val Ile Thr Val Lys 
225                 230                 235                 240 


His Asn Lys Thr Thr Ala Gln Val Leu Ile Xaa Phe Pro Ile Gln Arg 
                245                 250                 255     


Asn Leu Val Val Asn Pro Lys Ser Val Thr Gln Lys Cys Ile Ala Glu 
            260                 265                 270         


Asn Phe Lys Ala Phe Tyr Phe Glu Leu Ser Ser Lys Asp Met Thr Thr 
        275                 280                 285             


Leu Pro Ser Tyr Asn Arg Asn Cys Ala Leu Val Ser Cys Thr Ser His 
    290                 295                 300                 


Lys Asp Tyr Pro Phe 
305                 


<210>  1411
<211>  2448
<212>  DNA
<213>  Homosapiens

<400>  1411
acgtcccagc gtctgagaga acgagtaagc acagaattca aagcattctg cagcctgaat     60

tttgaaggag tgtgtttagg cactaagcaa gctgatttat gataactgct ttaaacttca    120

acaaccaaag gcataagaac taggagctgc tgacatttca atatgaaggg caactccacc    180

cttgccacta ctagcaaaaa cattaccagc ggtcttcact tcgggcttgt gaacatctct    240

ggcaacaatg agtctacctt gaactgttca cagaaaccat cagataagca tttagatgca    300

attcctattc tttactacat tatatttgta attggatttc tggtcaatat tgtcgtggtt    360

acactgtttt gttgtcaaaa gggtcctaaa aaggtttcta gcatatacat cttcaacctc    420

gctgtggctg atttactcct tttggctact cttcctctat gggcaaccta ttattcttat    480

agatatgact ggctctttgg acctgtgatg tgcaaagttt ttggttcttt tcttaccctg    540

aacatgtttg caagcatttt ttttatcacc tgcatgagtg ttgataggta ccaatctgtc    600

atctacccct ttctgtctca aagaagaaat ccctggcaag catcttatat agttcccctt    660

gtttggtgta tggcctgttt gtcctcattg ccaacatttt attttcgaga cgtcagaacc    720

attgaatact taggagtgaa tgcttgcatt atggctttcc cacctgagaa atatgcccaa    780

tggtcagctg ggattgcctt aatgaaaaat atccttggtt ttattatccc tttaatattc    840

atagcaacat gctattttgg aattagaaaa cacttactga agacgaatag ctatgggaag    900

aacaggataa cccgtgacca agtcctgaag atggcagctg ctgttgttct ggccttcatc    960

atttgctggc ttcccttcca tgttctgacc ttcctggatg ctctggcctg gatgggtgtc   1020

attaatagct gcgaagttat agcagtcatt gacctggcac ttccttttgc catcctcttg   1080

ggattcacca acagctgcgt taatccgttt ctgtattgtt ttgttggaaa ccggttccaa   1140

cagaagctcc gcagtgtgtt tagggttcca attacttggc tccaagggaa aagagagagt   1200

atgtcttgcc ggaaaagcag ttctcttaga gaaatggaga cctttgtgtc ttaaacgtga   1260

gagcaaaatg catgtaatca acatggctac ttgctttgag gctcaccaga attattttta   1320

agtggtttta ataaaataat aaaatttccc ctaatctttt ctgaatcttc tgaaaccaaa   1380

tgtaactatg ttttatcgtc cagtgacttt caggaattgc ccattgtttt tctgatatgt   1440

ttgtacaaga tttcattggt gagacatatt tacaacctag aagtaactgg tgatatatct   1500

caaattgtaa ttaataatag attgtgaata atgatttggg gattcagatt tctctttgaa   1560

acatgcttgt gtttcttagt ggggttttat atccattttt atcaggattt cctcttgaac   1620

cagaaccagt ctttcaactc attgcatcat ttacaagaca acattgtaag agagatgagc   1680

acttctaagt tgagtatatt ataatagatt agtactggat tattcaggct ttaggcatat   1740

gcttctttaa aaacgctata aattatattc ctcttgcatt tcacttgagt ggaggtttat   1800

agttaatcta taactacata ttgaataggg ctaggaatat agattaaatc atactcctat   1860

gctttagctt atttttacag ttatagaaag caagatgtac tataacatag aattgcaatc   1920

tataatattt gtgtgttcac taaactctga ataagcactt tttaaaaaac tttctactca   1980

ttttaatgat tgtttaaagg tttctatttt ctctgatact tttttgaaat cagtaaacac   2040

tgtgtattgt tgtaaaatgt aaaggtcact tttcacatcc ttgacttttt agatgtgctg   2100

ctttgatata taggacattg atttgatttt tattattaat gctttggttc tgggttgttt   2160

cctaaaatat ctgggtggct taaaaaaaac tctttaactt gtaataaacc cttaactggc   2220

ataggaaatg gtatccagaa tggaattttg ctacatgggg tctgggtggg ggcaaagaga   2280

cccagtcaat tacatgtttg gtaccaagaa aggaacctgt cagggcagta caatgtgact   2340

ttgaaaatat ataccgtggg ggtagtttta ccctatatct ataaacactg tttgttccag   2400

aatctgtatg attctatgga gctattttaa accaattgca ggtctaga                2448


<210>  1412
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  1412

Met Lys Gly Asn Ser Thr Leu Ala Thr Thr Ser Lys Asn Ile Thr Ser 
1               5                   10                  15      


Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Thr 
            20                  25                  30          


Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro 
        35                  40                  45              


Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val 
    50                  55                  60                  


Val Val Thr Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser 
65                  70                  75                  80  


Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Thr 
                85                  90                  95      


Leu Pro Leu Trp Ala Thr Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe 
            100                 105                 110         


Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Thr Leu Asn Met 
        115                 120                 125             


Phe Ala Ser Ile Phe Phe Ile Thr Cys Met Ser Val Asp Arg Tyr Gln 
    130                 135                 140                 


Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala 
145                 150                 155                 160 


Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu 
                165                 170                 175     


Pro Thr Phe Tyr Phe Arg Asp Val Arg Thr Ile Glu Tyr Leu Gly Val 
            180                 185                 190         


Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser 
        195                 200                 205             


Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu 
    210                 215                 220                 


Ile Phe Ile Ala Thr Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys 
225                 230                 235                 240 


Thr Asn Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Leu Lys 
                245                 250                 255     


Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe 
            260                 265                 270         


His Val Leu Thr Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn 
        275                 280                 285             


Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile 
    290                 295                 300                 


Leu Leu Gly Phe Thr Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe 
305                 310                 315                 320 


Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro 
                325                 330                 335     


Ile Thr Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser 
            340                 345                 350         


Ser Ser Leu Arg Glu Met Glu Thr Phe Val Ser 
        355                 360             


<210>  1413
<211>  4520
<212>  DNA
<213>  Homosapiens

<400>  1413
taggaacagg ggagagtgca cctgctacca gtcaagctca gccagactgc aagaggaggc     60

gaggcggagc cagccgaggg agtgaaccat ggacaagttg aaatgcccga gtttcttcaa    120

gtgcagggag aaggagaaag tgtcggcttc atcagagaat ttccatgttg gtgaaaatga    180

tgagaatcag gaccgtggta actggtccaa aaaatcggat tatcttctat ctatgattgg    240

atacgcagtg ggattaggaa atgtgtggag atttccatat ctgacctaca gcaatggtgg    300

aggcgccttc ttgatacctt atgcaattat gttagcattg gctggtttac ctttgttctt    360

tctggagtgt tcactgggac aatttgctag cttaggtcca gtttcagttt ggaggattct    420

tccattgttt caaggtgtgg gaattacaat ggtcctgatc tccatttttg tgacaatcta    480

ttacaatgtc ataattgcct atagtcttta ctacatgttt gcttcttttc aaagtgaact    540

accatggaaa aattgttctt cgtggtcaga taaaaactgt agcagatcac caatagtaac    600

tcactgtaat gtgagtacag tgaataaagg aatacaagag atcatccaaa tgaataaaag    660

ctgggtagac atcaacaatt ttacctgcat caacggcagt gaaatttatc agccagggca    720

gcttcccagt gaacaatatt ggaataaagt ggcgctccaa cggtcaagtg gaatgaatga    780

gactggagta attgtttggt atttagcact ttgtcttctt ctggcttggc tcatagttgg    840

agcagcacta tttaaaggaa tcaaatcgtc tggcaaggtg gtatatttta cagctctttt    900

cccctatgtg gtcctactca tcctgttagt acgaggtgca actctggagg gtgcttcaaa    960

aggcatttca tactatattg gagcccagtc aaattttaca aaacttaagg aagctgaggt   1020

atggaaagat gctgccactc agatatttta ctccctttca gtggcttggg gtggcttagt   1080

tgctctatca tcttacaata agttcaaaaa caactgcttc tctgatgcca ttgtggtttg   1140

tttgacaaac tgtctcacta gcgtgtttgc tggatttgct attttttcta tattgggaca   1200

catggcccat atatctggaa aggaagtttc tcaagttgta aaatcaggtt ttgatttggc   1260

attcattgcc tatccagagg ctctagccca actcccaggt ggtccatttt ggtccatatt   1320

attttttttc atgcttttaa ctttgggtct cgattctcag tttgcttcga ttgaaacgat   1380

cacaacaaca attcaagatt tatttcccaa agtgatgaag aaaatgaggg ttcccataac   1440

tttgggctgc tgcttggttt tgtttctcct tggtctcgtc tgtgtgactc aggctggaat   1500

ttactgggtt catctgattg accacttctg tgctggatgg ggcattttaa ttgcagctat   1560

actggagcta gttggaatca tctggattta tggagggaac agattcattg aggatacaga   1620

aatgatgatt ggagcaaaga ggtggatatt ctggctatgg tggagagctt gctggtttgt   1680

aattacgcct atccttttga ttgcaatatt tatctggtca ttggtgcaat ttcatagacc   1740

taattatggc gcaattccat accctgactg gggagttgct ttaggctggt gtatgattgt   1800

tttctgcatt atttggatac caattatggc tatcataaaa ataattcagg ctaaaggaaa   1860

catctttcaa cgccttataa gttgctgcag accagcttct aactggggtc catacctgga   1920

acaacatcgt ggggaaagat ataaagacat ggtagatcct aaaaaagagg ctgaccatga   1980

aatacctact gttagtggca gcagaaaacc ggaatgagat ctcattgaaa aaaatatatg   2040

attgtataat gtgatttttt ttagaatagg gggaacctta tttatttgtg tgttaactga   2100

ataggaaaat gtacatacta tgttcatgat agtgtgattt ttttcacatt taagcaggaa   2160

tgcaatataa aaatgtgaat ctcttaattc tcagccatgt gcttattata tttcttttta   2220

gattgtctat ctgtataaca cacacacaca cacctaagag tctctatttc acaattatat   2280

ttttgtaaat agtatatgca tttttaatac attggaggct ttattttgaa ctaatttctt   2340

agagaatagt tatattttct attacacaag tttaaaaata ttattaactt gtattttctt   2400

aatatacaat ctatcttttc cacaaatatg agtgggaaat aaatcagcac atttgaaaga   2460

aagtgttaaa actgaaggcc tcacttaatt agaaacgtga taaatatatg gacaaatgga   2520

ctatacatac tataagagga ctgtagttta atacttttta cccaaatatg tttaaaaaca   2580

tcgtgcattt gttacagctc atgttttcta tatgaactta gtcattaatg ttctttataa   2640

aaagtgaaat aagatggaaa aattaggatc ctacagccag tacgtgataa atctagaaaa   2700

ttgagttttg agtacctctt ttcccatata caatcttcct tccttaggta atttggaaga   2760

aaactatgac ccatttaatt tctattgtgt ttcaccaaat tcagtgttgt tcattatacc   2820

tctctgaaat ataggtttaa tttcaaatag aatatggact taaatgttaa tgagaaactg   2880

gctttaatca attctagcat tttattactg taatacaggg ctgatagagt gattttgtct   2940

tatatgagtc agttactact tacaggtgat aacttgcata ctattggaag ataaagttgt   3000

caaacttgtc aagaatgaga aaagccaaat tagaaaatcc tatgtcctag tttccttacc   3060

aaggataatt aaatatatca ctaagagctt tatatattga ttatatattg ttgacaactg   3120

gtttaagcat catagcctat gatgataaac actgcctata tatgtaaata gcttttcatc   3180

aattcttaaa tttcttaacc taggcttcag ggagcatatg aaaccaaaat tatatggaac   3240

attttctgtg tgtacatgta catgcatttt tctagggaga gagtccgtag gtttatcaga   3300

atatcaagga aaactgtgac ccaaagaagt ttaagaatca catacagtgc tgctggcttt   3360

ttgtgcttgg caaatgagtg acaatagaag aaataatttt tcttacacat tttaaaacgt   3420

tttctcttcc ttgtgattga agatgaaagg agtaagaaat taaggcattt gtttaattta   3480

tactggtaac ttatttaggg gggaggggac atgaaggtag gtaaataggt aggcctctaa   3540

ttgaaccacc tctctaagtt atgtacgtat atataagctg aaattgtgtt tgacattctg   3600

agggttttct ttttcttttt cctttttttt tttttttggt ggggggctgg gggtcagagt   3660

cttgttctgt tgcctgggct ggagtgcagt ggcatgatct cagctcactg caacctctgc   3720

cttctggatt caagtgattc tcctgcctca gcctcttgag tagctgggac tacaggtgcc   3780

cgccaccaca ccagctaatt tttgtatttt tagtagaggc gaagtttccc catgttggcc   3840

aggctggtct tgaactcccg acctcaagtg atctgtctac ctcggcctcc taaagtgctg   3900

agattacagg tgtgagccac cgtgcccggc ccattctaag ggttttcttt gaagacaggt   3960

caaatgctgt tagtaagttt caggagattg ttaattcctc agttatacca gattttataa   4020

aatatttgag aatagatggc taacaagagg ttagaaatac ttttccttaa ttttaatcca   4080

cagtatgtta catgcattct accactacat tttggtgcta tttaaggtgt gcaattttct   4140

ataggtgact tttgcaattc agggaagatt tgggcatatt aaatgaaaga atatctaatt   4200

gggggaggtg tgaagggaaa gaaattcttt tcaaaagctg accacaaaga gtagttaaaa   4260

gtttttgtca ctatcttcac aagtgtgtaa agcacagatt tcaacagagt gcttggcata   4320

ttgtagggtg ctcaatggtg gtttttatta ttattactca gattccacag tggcaagaaa   4380

catcattcta cataatggaa aacatttaca tcaaatccca cttactttaa tgcgaacttg   4440

gagataattt atggtattgt attgtaaacc attaatgaaa actttttcac agttgagtga   4500

aattaaaatc actatatctc                                               4520


<210>  1414
<211>  642
<212>  PRT
<213>  Homosapiens

<400>  1414

Met Asp Lys Leu Lys Cys Pro Ser Phe Phe Lys Cys Arg Glu Lys Glu 
1               5                   10                  15      


Lys Val Ser Ala Ser Ser Glu Asn Phe His Val Gly Glu Asn Asp Glu 
            20                  25                  30          


Asn Gln Asp Arg Gly Asn Trp Ser Lys Lys Ser Asp Tyr Leu Leu Ser 
        35                  40                  45              


Met Ile Gly Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Thr Tyr Ser Asn Gly Gly Gly Ala Phe Leu Ile Pro Tyr Ala Ile 
65                  70                  75                  80  


Met Leu Ala Leu Ala Gly Leu Pro Leu Phe Phe Leu Glu Cys Ser Leu 
                85                  90                  95      


Gly Gln Phe Ala Ser Leu Gly Pro Val Ser Val Trp Arg Ile Leu Pro 
            100                 105                 110         


Leu Phe Gln Gly Val Gly Ile Thr Met Val Leu Ile Ser Ile Phe Val 
        115                 120                 125             


Thr Ile Tyr Tyr Asn Val Ile Ile Ala Tyr Ser Leu Tyr Tyr Met Phe 
    130                 135                 140                 


Ala Ser Phe Gln Ser Glu Leu Pro Trp Lys Asn Cys Ser Ser Trp Ser 
145                 150                 155                 160 


Asp Lys Asn Cys Ser Arg Ser Pro Ile Val Thr His Cys Asn Val Ser 
                165                 170                 175     


Thr Val Asn Lys Gly Ile Gln Glu Ile Ile Gln Met Asn Lys Ser Trp 
            180                 185                 190         


Val Asp Ile Asn Asn Phe Thr Cys Ile Asn Gly Ser Glu Ile Tyr Gln 
        195                 200                 205             


Pro Gly Gln Leu Pro Ser Glu Gln Tyr Trp Asn Lys Val Ala Leu Gln 
    210                 215                 220                 


Arg Ser Ser Gly Met Asn Glu Thr Gly Val Ile Val Trp Tyr Leu Ala 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Ala Trp Leu Ile Val Gly Ala Ala Leu Phe Lys 
                245                 250                 255     


Gly Ile Lys Ser Ser Gly Lys Val Val Tyr Phe Thr Ala Leu Phe Pro 
            260                 265                 270         


Tyr Val Val Leu Leu Ile Leu Leu Val Arg Gly Ala Thr Leu Glu Gly 
        275                 280                 285             


Ala Ser Lys Gly Ile Ser Tyr Tyr Ile Gly Ala Gln Ser Asn Phe Thr 
    290                 295                 300                 


Lys Leu Lys Glu Ala Glu Val Trp Lys Asp Ala Ala Thr Gln Ile Phe 
305                 310                 315                 320 


Tyr Ser Leu Ser Val Ala Trp Gly Gly Leu Val Ala Leu Ser Ser Tyr 
                325                 330                 335     


Asn Lys Phe Lys Asn Asn Cys Phe Ser Asp Ala Ile Val Val Cys Leu 
            340                 345                 350         


Thr Asn Cys Leu Thr Ser Val Phe Ala Gly Phe Ala Ile Phe Ser Ile 
        355                 360                 365             


Leu Gly His Met Ala His Ile Ser Gly Lys Glu Val Ser Gln Val Val 
    370                 375                 380                 


Lys Ser Gly Phe Asp Leu Ala Phe Ile Ala Tyr Pro Glu Ala Leu Ala 
385                 390                 395                 400 


Gln Leu Pro Gly Gly Pro Phe Trp Ser Ile Leu Phe Phe Phe Met Leu 
                405                 410                 415     


Leu Thr Leu Gly Leu Asp Ser Gln Phe Ala Ser Ile Glu Thr Ile Thr 
            420                 425                 430         


Thr Thr Ile Gln Asp Leu Phe Pro Lys Val Met Lys Lys Met Arg Val 
        435                 440                 445             


Pro Ile Thr Leu Gly Cys Cys Leu Val Leu Phe Leu Leu Gly Leu Val 
    450                 455                 460                 


Cys Val Thr Gln Ala Gly Ile Tyr Trp Val His Leu Ile Asp His Phe 
465                 470                 475                 480 


Cys Ala Gly Trp Gly Ile Leu Ile Ala Ala Ile Leu Glu Leu Val Gly 
                485                 490                 495     


Ile Ile Trp Ile Tyr Gly Gly Asn Arg Phe Ile Glu Asp Thr Glu Met 
            500                 505                 510         


Met Ile Gly Ala Lys Arg Trp Ile Phe Trp Leu Trp Trp Arg Ala Cys 
        515                 520                 525             


Trp Phe Val Ile Thr Pro Ile Leu Leu Ile Ala Ile Phe Ile Trp Ser 
    530                 535                 540                 


Leu Val Gln Phe His Arg Pro Asn Tyr Gly Ala Ile Pro Tyr Pro Asp 
545                 550                 555                 560 


Trp Gly Val Ala Leu Gly Trp Cys Met Ile Val Phe Cys Ile Ile Trp 
                565                 570                 575     


Ile Pro Ile Met Ala Ile Ile Lys Ile Ile Gln Ala Lys Gly Asn Ile 
            580                 585                 590         


Phe Gln Arg Leu Ile Ser Cys Cys Arg Pro Ala Ser Asn Trp Gly Pro 
        595                 600                 605             


Tyr Leu Glu Gln His Arg Gly Glu Arg Tyr Lys Asp Met Val Asp Pro 
    610                 615                 620                 


Lys Lys Glu Ala Asp His Glu Ile Pro Thr Val Ser Gly Ser Arg Lys 
625                 630                 635                 640 


Pro Glu 
        


<210>  1415
<211>  1012
<212>  DNA
<213>  Homosapiens

<400>  1415
atggctctag atgctgcttt agagactctc tgcttcagga aagtgaggca gctaggcaga     60

aggagaaggt cggattgtag aagctggggt ggccggcagc tcgctcatcg gtgttcgtgg    120

gctttgtcgg tccgtgcctc gtctctccct ggaaagggag ggaggcttca acgtcgagag    180

ggagccgctg ccgcgttagt tccgagcttg aagtcactag gacttctctc aaacttgagt    240

gctgaggaga ctcagatgtt ggcctcagct cctaggctga actcagcaga tcggcccatg    300

aaaacttctg tattgagaca aaggaaggga tctgtcagaa agcaacactt gttatcttgg    360

gcttggcagc aaggaagagg acaggtagtg gagatcctgc aatctgaaaa gcagactgaa    420

aggtgacaaa gaagctgaag atgggtggta gagagaggta taacattcca gcccctcaat    480

ctagaaatgt tagtaagaac caacaacagc ttaacagaca gaagaccaag gaacagaatt    540

cccagatgaa gattgttcat aagaaaaaag aaagaggaca tggttataac tcatcagcag    600

gtgcctggca ggccatgaaa aatgggggga agaacaaaaa ttttccaaat aatcaaagtt    660

ggaattctag cttatcaggt cccagcttac tttttaaatc tcaagctaaa cagaactatg    720

ctggtgccaa atttagtgag ccgccatcac caagtgttct tcccaaacca ccaagccact    780

gggtccctgt ttcctttaat ccttcagata aggaaataat gacatttcaa cttaaaacct    840

tacttaaagt acaggtataa aataagacaa atgtttaagt ttagttatgt tcacagatag    900

ttgtcaattg gtctgaaaca aatttgctag ggaatctatt tgtgtagaac taattaatgt    960

aaaaaaaata gacttcatct cgtgttgtgt gcactgtgat ataatggggt ag           1012


<210>  1416
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  1416

Met Ala Leu Asp Ala Ala Leu Glu Thr Leu Cys Phe Arg Lys Val Arg 
1               5                   10                  15      


Gln Leu Gly Arg Arg Arg Arg Ser Asp Cys Arg Ser Trp Gly Gly Arg 
            20                  25                  30          


Gln Leu Ala His Arg Cys Ser Trp Ala Leu Ser Val Arg Ala Ser Ser 
        35                  40                  45              


Leu Pro Gly Lys Gly Gly Arg Leu Gln Arg Arg Glu Gly Ala Ala Ala 
    50                  55                  60                  


Ala Leu Val Pro Ser Leu Lys Ser Leu Gly Leu Leu Ser Asn Leu Ser 
65                  70                  75                  80  


Ala Glu Glu Thr Gln Met Leu Ala Ser Ala Pro Arg Leu Asn Ser Ala 
                85                  90                  95      


Asp Arg Pro Met Lys Thr Ser Val Leu Arg Gln Arg Lys Gly Ser Val 
            100                 105                 110         


Arg Lys Gln His Leu Leu Ser Trp Ala Trp Gln Gln Gly Arg Gly Gln 
        115                 120                 125             


Val Val Glu Ile Leu Gln Ser Glu Lys Gln Thr Glu Arg 
    130                 135                 140     


<210>  1417
<211>  2880
<212>  DNA
<213>  Homosapiens

<400>  1417
actccagtct cctgggactt tgactcgccg tactcggcgc gctcctgctg agggtcgccg     60

gagatgtcgc tcggccgcct tctaccagga gcctgatccg tgccgcccgc cgcccggatg    120

ggaccaccag agtgctctaa gtctccagtg aatattgaat tgctgaggat tttgggaaaa    180

gacaaatcaa agttcccatt ccatggatcc cttaggtgca ccttcccagt ttgtggatgt    240

ggatacacta ccaagctggg gtgactcatg ccaagatgaa ttaaattcct ctgatactac    300

agctgaaata tttcaggaag acactgttcg atcacctttt ctttataata aggacgtcaa    360

tggaaaagtg gttctttgga aaggagatgt ggcattactg aactgtacag ccattgtgaa    420

taccagcaat gaaagtctca cagataagaa tcctgtgtca gaaagtatct tcatgcttgc    480

agggcctgat ttgaaggaag atctccagaa acttaaaggg tgccgaacag gtgaagcaaa    540

attgacaaaa ggattcaatc tagctgcccg gttcatcatt cacacagtgg gacctaaata    600

taaaagccgc tatcgcacag cagctgagag ttccctttat agctgctaca gaaacgtact    660

tcaactagca aaagagcagt caatgtcttc tgttggcttc tgtgtcatca attctgcaaa    720

acgtggttat cctttagagg atgcaacaca catagcactt cgcactgtaa gaagattcct    780

agagattcat ggggaaacca ttgaaaaagt agtatttgct gtctctgatc ttgaagaggg    840

tacttaccaa aagctgctac ctctctactt cccaaggtca ttaaaagagg agaatcgatc    900

attgccctac ctacctgcag atattggaaa tgcagaaggg gagcctgtgg tacctgaacg    960

acagattaga ataagtgaga aacctggtgc tccagaagat aaccaagaag aggaggatga   1020

aggcttggga gttgatctct ctttcattgg ctctcatgct tttgctcgaa tggaaggaga   1080

tattgacaag caaagaaaac tgatccttca gggacaatta tcagaggcag ctctgcagaa   1140

gcagcatcaa agaaattata atcgctggtt atgtcaagca agatctgagg atctgtctga   1200

tattgcttct ctaaaagcct tataccaaac aggtgttgat aactgtggtc ggacagtgat   1260

ggtggtagtt ggaagaaaca ttcctgtaac attaatagat atggacaagg ctctcttata   1320

tttcattcat gtaatggatc acattgctgt gaaggagtat gtattagtgt attttcacac   1380

cctgaccagc gaatacaatc acctggactc cgacttcctg aagaaactct acgatgttgt   1440

tgatgtcaag tacaagagga atttgaaggc tgtttatttt gtacatccca catttcgttc   1500

aaaggtgtca acatggtttt ttaccacctt ttctgtctca ggactgaagg acaaaatcca   1560

ccatgtggac agcctccacc agctgttttc tgccatatca ccagaacaga ttgactttcc   1620

tccttttgtc cttgaatatg atgccaggga aaacgggcct tactatacat catatccccc   1680

atcaccagat ttgtgacctg ccatctttca gtgcttcttg gttcccagga tgccacttcc   1740

tccacgaata gctacctgtt gaagtgatat tcattgttgc tgtacagatc cagagagcct   1800

tttgtcccca cctctctggt atttttttat tgactgtata ttttctggca cataagcaat   1860

ctaaaaatgg taggccattc tgaactgcac acattttaaa tttgtatatt tatatgaaat   1920

ggaaatgttc atttttagat tgttaataga aattggggag caacttttga gtatctttag   1980

tttcctgaag gacaccgaat tctccattag ataaaccacc aagactgttc acatcatctc   2040

tctaacattg cacgcttcct ttgtgtactt aagtgattct cgaaatatac agaaccaatg   2100

tatgctaacc agatgcattg tttgcttcag atccatggtg ttaataccat gtatatttta   2160

taaagataat ttggctgtgt taaaagagaa ttacctgagt ccaagaatgt ggaaatgtat   2220

ctgacaaaaa acatcaaaat cattagcaaa acataggact tagaatgtta atgtacaagt   2280

taagactaaa gtttaaggac taaggttcct tggattatat gacttgttaa gattgccaca   2340

gttccgatct caacagtgtg gggtgaaaca agaagactgt atcttcagcc tttttcctat   2400

aatcatggat gatttggtct tattcaaaag gaccgcacat attagtactc ttaagagcat   2460

cttccaagac tccagcagtg agcatttaga gagtgtgttg tcttccagag tcatgaatga   2520

ttttgtttag ctatcaggtc tactacctct aaggacattt catagcagca tctcttgagt   2580

tgcctgcatc agtgtggagg aagtgtgtca cagtgaacaa atccagggag ctgataattg   2640

gcaaaagacc acttttacca ctcaggctct atttgtgcct tagcttggtt atgagtaaaa   2700

attagaatta tgctgcctac ctcacagagg tatcatgaag atagcattta gaaagggctt   2760

tgttgtggtg gggtatcttc agttagtttt taaatgggaa taaatatata tgagggaatg   2820

ctacacagca ctcctcttgt ccttgatccc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2880


<210>  1418
<211>  497
<212>  PRT
<213>  Homosapiens

<400>  1418

Met Asp Pro Leu Gly Ala Pro Ser Gln Phe Val Asp Val Asp Thr Leu 
1               5                   10                  15      


Pro Ser Trp Gly Asp Ser Cys Gln Asp Glu Leu Asn Ser Ser Asp Thr 
            20                  25                  30          


Thr Ala Glu Ile Phe Gln Glu Asp Thr Val Arg Ser Pro Phe Leu Tyr 
        35                  40                  45              


Asn Lys Asp Val Asn Gly Lys Val Val Leu Trp Lys Gly Asp Val Ala 
    50                  55                  60                  


Leu Leu Asn Cys Thr Ala Ile Val Asn Thr Ser Asn Glu Ser Leu Thr 
65                  70                  75                  80  


Asp Lys Asn Pro Val Ser Glu Ser Ile Phe Met Leu Ala Gly Pro Asp 
                85                  90                  95      


Leu Lys Glu Asp Leu Gln Lys Leu Lys Gly Cys Arg Thr Gly Glu Ala 
            100                 105                 110         


Lys Leu Thr Lys Gly Phe Asn Leu Ala Ala Arg Phe Ile Ile His Thr 
        115                 120                 125             


Val Gly Pro Lys Tyr Lys Ser Arg Tyr Arg Thr Ala Ala Glu Ser Ser 
    130                 135                 140                 


Leu Tyr Ser Cys Tyr Arg Asn Val Leu Gln Leu Ala Lys Glu Gln Ser 
145                 150                 155                 160 


Met Ser Ser Val Gly Phe Cys Val Ile Asn Ser Ala Lys Arg Gly Tyr 
                165                 170                 175     


Pro Leu Glu Asp Ala Thr His Ile Ala Leu Arg Thr Val Arg Arg Phe 
            180                 185                 190         


Leu Glu Ile His Gly Glu Thr Ile Glu Lys Val Val Phe Ala Val Ser 
        195                 200                 205             


Asp Leu Glu Glu Gly Thr Tyr Gln Lys Leu Leu Pro Leu Tyr Phe Pro 
    210                 215                 220                 


Arg Ser Leu Lys Glu Glu Asn Arg Ser Leu Pro Tyr Leu Pro Ala Asp 
225                 230                 235                 240 


Ile Gly Asn Ala Glu Gly Glu Pro Val Val Pro Glu Arg Gln Ile Arg 
                245                 250                 255     


Ile Ser Glu Lys Pro Gly Ala Pro Glu Asp Asn Gln Glu Glu Glu Asp 
            260                 265                 270         


Glu Gly Leu Gly Val Asp Leu Ser Phe Ile Gly Ser His Ala Phe Ala 
        275                 280                 285             


Arg Met Glu Gly Asp Ile Asp Lys Gln Arg Lys Leu Ile Leu Gln Gly 
    290                 295                 300                 


Gln Leu Ser Glu Ala Ala Leu Gln Lys Gln His Gln Arg Asn Tyr Asn 
305                 310                 315                 320 


Arg Trp Leu Cys Gln Ala Arg Ser Glu Asp Leu Ser Asp Ile Ala Ser 
                325                 330                 335     


Leu Lys Ala Leu Tyr Gln Thr Gly Val Asp Asn Cys Gly Arg Thr Val 
            340                 345                 350         


Met Val Val Val Gly Arg Asn Ile Pro Val Thr Leu Ile Asp Met Asp 
        355                 360                 365             


Lys Ala Leu Leu Tyr Phe Ile His Val Met Asp His Ile Ala Val Lys 
    370                 375                 380                 


Glu Tyr Val Leu Val Tyr Phe His Thr Leu Thr Ser Glu Tyr Asn His 
385                 390                 395                 400 


Leu Asp Ser Asp Phe Leu Lys Lys Leu Tyr Asp Val Val Asp Val Lys 
                405                 410                 415     


Tyr Lys Arg Asn Leu Lys Ala Val Tyr Phe Val His Pro Thr Phe Arg 
            420                 425                 430         


Ser Lys Val Ser Thr Trp Phe Phe Thr Thr Phe Ser Val Ser Gly Leu 
        435                 440                 445             


Lys Asp Lys Ile His His Val Asp Ser Leu His Gln Leu Phe Ser Ala 
    450                 455                 460                 


Ile Ser Pro Glu Gln Ile Asp Phe Pro Pro Phe Val Leu Glu Tyr Asp 
465                 470                 475                 480 


Ala Arg Glu Asn Gly Pro Tyr Tyr Thr Ser Tyr Pro Pro Ser Pro Asp 
                485                 490                 495     


Leu 
    


<210>  1419
<211>  3850
<212>  DNA
<213>  Homosapiens

<400>  1419
ctcgtggagg ctgagattgc ttcacctgtg gtatcagaca tcacaacatg gggctcacca     60

agcagtacct acgctatgtt gctagtgcgg tctttggcgt tatcggcagc caaaaaggta    120

atattgtctt tgtgacactt cgtggtgaga aaggacgtta tgtggcagta ccagcttgtg    180

aacacgtttt catctgggac ttaaggaaag gagagaagat tcttatcctt caggggctta    240

aacaagaagt tacttgctta tgcccctccc cagatgggct acacttagct gttgggtatg    300

aggatgggtc gatccgaatc ttcagtctcc tgagtgggga aggaaatgtg accttcaatg    360

gtcacaaagc agctatcact accttgaagt atgatcagct aggaggcaga ctggcatctg    420

ggtccaagga cacagatatt attgtatggg atgtgatcaa tgaaagtggt ctgtaccgtc    480

taaaggggca caaggatgcc atcacacaag cattgtttct acgagaaaag aacctgctag    540

ttactagtgg gaaagatacc atggtgaaat ggtgggacct tgatactcag cactgcttta    600

aaacaatggt tggccaccgg actgaggtat gggggttggt tctgttgtca gaagaaaagc    660

gactcatcac tggggcctca gacagtgaac tgagggtatg ggacatagct tatctgcaag    720

agattgaaga cccggaagaa ccagacccca agaaaatcaa aggatcttct cctggaatac    780

aagatactct tgaggcagag gatggtgcct ttgagacgga tgaagcccct gaggatcgaa    840

tcctttcatg cagaaaagct ggttccataa tgcgggaagg aagagacaga gttgtaaacc    900

ttgcagtcga caagacaggc aggattcttg cttgccatgg aactgactct gtgctagaat    960

tgttttgtat cctttccaaa aaggaaattc agaagaaaat ggataagaag atgaagaaag   1020

ctagaaagaa agcaaaatta cattctagca aaggagagga ggaagatcct gaggttaatg   1080

ttgaaatgag tctgcaagat gaaatccagc gggtgactaa tataaaaact tctgccaaaa   1140

tcaagtcctt tgacttgatt cattcacctc acggagagtt aaaggctgtc ttcctgctgc   1200

agaacaacct ggtggaattg tattcactga atccatcctt gcctactcct cagcctgtca   1260

ggacaagcag aatcactatt gggggtcatc gcagtgatgt gcggactttg tcattcagct   1320

cagacaatat tgctgttctt tcagctgcag ctgattccat taaaatatgg aacaggtcta   1380

cactgcagtg tattcgcaca atgacctgtg aatatgcact ttgctcattc tttgtacctg   1440

gtgatagaca ggtagtcata ggaacaaaga cagggaagct gcagctttat gacttggctt   1500

cagggaatct gctggagaca atagatgcac atgatggagc tttatggtcc atgtccctct   1560

ctccagatca gcgtggcttt gtgacaggtg gtgcagataa atctgtcaaa ttctgggatt   1620

ttgagttagt gaaagatgaa aatagtaccc aaaagagact ttctgtgaag caaacccgaa   1680

ctttgcaact agatgaagat gttctgtgtg tcagttactc tcccaatcaa aagctattgg   1740

ctgtgtcttt gctggactgt actgtgaaaa ttttctacgt tgatacttta aagttttttc   1800

tgtcactgta tggacacaaa ctgcctgtta tatgcatgga catctctcat gatggagcac   1860

tcatagcaac tggctccgct gataggaatg tgaaaatctg gggtttggac tttggggact   1920

gccacaagtc tctctttgca catgatgaca gtgtgatgta cctacagttt gtacccaagt   1980

ctcacctctt cttcactgcc ggaaaagatc ataagattaa acagtgggat gcagacaaat   2040

ttgaacacat acagactctg gagggtcatc accaggaaat atggtgtttg gctgtaagcc   2100

ccagtggaga ctatgttgta tcatcgtccc atgacaaatc tctgagactt tgggagagaa   2160

caagggagcc tcttattctt gaggaagaaa gggagatgga aagagaagca gaatatgagg   2220

agagtgtggc caaagaagac caaccagcag ttccaggaga gactcaaggt gacagttact   2280

ttactggaaa gaaaactatt gaaacagtga aagcagctga gaggattatg gaggctattg   2340

agttgtaccg agaagaaact gcaaaaatga aggaacacaa agccatttgt aaagctgcag   2400

ggaaagaggt tccacttccc agcaacccca tcctaatggc ttatggcagt atctcacctt   2460

cagcttatgt attagagatt tttaaaggga tcaagtcgag tgagctggaa gaatctctac   2520

ttgtgctgcc tttctcttat gtcccagaca ttcttaaact ctttaacgaa ttcattcagc   2580

tgggctctga tgttgaactt atatgccggt gcctcttctt cctccttagg attcactttg   2640

gacagatcac tagcaatcaa atgcttgtgc cagtgataga aaaattaagg gaaacaacta   2700

tttcaaaagt cagccaagtc cgggatgtta tcggcttcaa tatggctggt cttgattatc   2760

tcaagaggga atgcgaggca aaaagtgaag ttatgttttt tgctgatgct actagccact   2820

tggaagagaa gaagaggaag aggaaaaaga gggagaagtt gattctaacg ttgacttaga   2880

actgaaatgt ggtatctttt ttttttcaac tttttccttt aaaggactcc taaactaagc   2940

acagaagagt tggcgtcatc ttaaaaatac caaataacag aagatcgcat tgcagatgat   3000

atcaggatgt ggtttccagc tttgcctgat ggaattccaa catgagatta tgggctgggc   3060

tccatttctt ggacttaaaa tgcattatta gtttaaaaac tttctgtgct ctcaaagctt   3120

gagccttgca gctcaagctt gttgttccct ttatattcta gcagggaata aataattgtt   3180

ttaattaggt atttgtttca ttggagttga aattaacatt tcaaaagttt ttcgtatttt   3240

tttatggcag atgatttgtc atttatttat attaggtttt actgcctatt gagacaacca   3300

ggtgcataat tgattgccct ttggccataa aaatgcagtg tcatggatct tagagctaaa   3360

aaggactgta aaaattaccc agaacagcgt cctcagactt aaccttctgc aagttatgtc   3420

tgtatataag aagattctaa ttgctaactg tttatacttt tctgaataaa atagttgttt   3480

ctaattaaaa agtagccaag ctaagatgcc tggctgggct tctgaggaat taatacactt   3540

cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgtatgtaca catacatata   3600

tatagttgac acttgaaaaa tgcaggtggt aggggcactg acccacccct acgccccgca   3660

cagtcaaaaa tctgcatata acttttgatt ccccaaagtc ttaagtacta gtagcctgtt   3720

attgactggg agcctgactg atgtattata tatattgtat actgtattct taaagtaagc   3780

tagagaaaag aaaatgttac ttagaaaatc ataaggaaga gaaaatatat ttactgtgtt   3840

tatcaatact                                                          3850


<210>  1420
<211>  943
<212>  PRT
<213>  Homosapiens

<400>  1420

Met Gly Leu Thr Lys Gln Tyr Leu Arg Tyr Val Ala Ser Ala Val Phe 
1               5                   10                  15      


Gly Val Ile Gly Ser Gln Lys Gly Asn Ile Val Phe Val Thr Leu Arg 
            20                  25                  30          


Gly Glu Lys Gly Arg Tyr Val Ala Val Pro Ala Cys Glu His Val Phe 
        35                  40                  45              


Ile Trp Asp Leu Arg Lys Gly Glu Lys Ile Leu Ile Leu Gln Gly Leu 
    50                  55                  60                  


Lys Gln Glu Val Thr Cys Leu Cys Pro Ser Pro Asp Gly Leu His Leu 
65                  70                  75                  80  


Ala Val Gly Tyr Glu Asp Gly Ser Ile Arg Ile Phe Ser Leu Leu Ser 
                85                  90                  95      


Gly Glu Gly Asn Val Thr Phe Asn Gly His Lys Ala Ala Ile Thr Thr 
            100                 105                 110         


Leu Lys Tyr Asp Gln Leu Gly Gly Arg Leu Ala Ser Gly Ser Lys Asp 
        115                 120                 125             


Thr Asp Ile Ile Val Trp Asp Val Ile Asn Glu Ser Gly Leu Tyr Arg 
    130                 135                 140                 


Leu Lys Gly His Lys Asp Ala Ile Thr Gln Ala Leu Phe Leu Arg Glu 
145                 150                 155                 160 


Lys Asn Leu Leu Val Thr Ser Gly Lys Asp Thr Met Val Lys Trp Trp 
                165                 170                 175     


Asp Leu Asp Thr Gln His Cys Phe Lys Thr Met Val Gly His Arg Thr 
            180                 185                 190         


Glu Val Trp Gly Leu Val Leu Leu Ser Glu Glu Lys Arg Leu Ile Thr 
        195                 200                 205             


Gly Ala Ser Asp Ser Glu Leu Arg Val Trp Asp Ile Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ile Glu Asp Pro Glu Glu Pro Asp Pro Lys Lys Ile Lys Gly Ser 
225                 230                 235                 240 


Ser Pro Gly Ile Gln Asp Thr Leu Glu Ala Glu Asp Gly Ala Phe Glu 
                245                 250                 255     


Thr Asp Glu Ala Pro Glu Asp Arg Ile Leu Ser Cys Arg Lys Ala Gly 
            260                 265                 270         


Ser Ile Met Arg Glu Gly Arg Asp Arg Val Val Asn Leu Ala Val Asp 
        275                 280                 285             


Lys Thr Gly Arg Ile Leu Ala Cys His Gly Thr Asp Ser Val Leu Glu 
    290                 295                 300                 


Leu Phe Cys Ile Leu Ser Lys Lys Glu Ile Gln Lys Lys Met Asp Lys 
305                 310                 315                 320 


Lys Met Lys Lys Ala Arg Lys Lys Ala Lys Leu His Ser Ser Lys Gly 
                325                 330                 335     


Glu Glu Glu Asp Pro Glu Val Asn Val Glu Met Ser Leu Gln Asp Glu 
            340                 345                 350         


Ile Gln Arg Val Thr Asn Ile Lys Thr Ser Ala Lys Ile Lys Ser Phe 
        355                 360                 365             


Asp Leu Ile His Ser Pro His Gly Glu Leu Lys Ala Val Phe Leu Leu 
    370                 375                 380                 


Gln Asn Asn Leu Val Glu Leu Tyr Ser Leu Asn Pro Ser Leu Pro Thr 
385                 390                 395                 400 


Pro Gln Pro Val Arg Thr Ser Arg Ile Thr Ile Gly Gly His Arg Ser 
                405                 410                 415     


Asp Val Arg Thr Leu Ser Phe Ser Ser Asp Asn Ile Ala Val Leu Ser 
            420                 425                 430         


Ala Ala Ala Asp Ser Ile Lys Ile Trp Asn Arg Ser Thr Leu Gln Cys 
        435                 440                 445             


Ile Arg Thr Met Thr Cys Glu Tyr Ala Leu Cys Ser Phe Phe Val Pro 
    450                 455                 460                 


Gly Asp Arg Gln Val Val Ile Gly Thr Lys Thr Gly Lys Leu Gln Leu 
465                 470                 475                 480 


Tyr Asp Leu Ala Ser Gly Asn Leu Leu Glu Thr Ile Asp Ala His Asp 
                485                 490                 495     


Gly Ala Leu Trp Ser Met Ser Leu Ser Pro Asp Gln Arg Gly Phe Val 
            500                 505                 510         


Thr Gly Gly Ala Asp Lys Ser Val Lys Phe Trp Asp Phe Glu Leu Val 
        515                 520                 525             


Lys Asp Glu Asn Ser Thr Gln Lys Arg Leu Ser Val Lys Gln Thr Arg 
    530                 535                 540                 


Thr Leu Gln Leu Asp Glu Asp Val Leu Cys Val Ser Tyr Ser Pro Asn 
545                 550                 555                 560 


Gln Lys Leu Leu Ala Val Ser Leu Leu Asp Cys Thr Val Lys Ile Phe 
                565                 570                 575     


Tyr Val Asp Thr Leu Lys Phe Phe Leu Ser Leu Tyr Gly His Lys Leu 
            580                 585                 590         


Pro Val Ile Cys Met Asp Ile Ser His Asp Gly Ala Leu Ile Ala Thr 
        595                 600                 605             


Gly Ser Ala Asp Arg Asn Val Lys Ile Trp Gly Leu Asp Phe Gly Asp 
    610                 615                 620                 


Cys His Lys Ser Leu Phe Ala His Asp Asp Ser Val Met Tyr Leu Gln 
625                 630                 635                 640 


Phe Val Pro Lys Ser His Leu Phe Phe Thr Ala Gly Lys Asp His Lys 
                645                 650                 655     


Ile Lys Gln Trp Asp Ala Asp Lys Phe Glu His Ile Gln Thr Leu Glu 
            660                 665                 670         


Gly His His Gln Glu Ile Trp Cys Leu Ala Val Ser Pro Ser Gly Asp 
        675                 680                 685             


Tyr Val Val Ser Ser Ser His Asp Lys Ser Leu Arg Leu Trp Glu Arg 
    690                 695                 700                 


Thr Arg Glu Pro Leu Ile Leu Glu Glu Glu Arg Glu Met Glu Arg Glu 
705                 710                 715                 720 


Ala Glu Tyr Glu Glu Ser Val Ala Lys Glu Asp Gln Pro Ala Val Pro 
                725                 730                 735     


Gly Glu Thr Gln Gly Asp Ser Tyr Phe Thr Gly Lys Lys Thr Ile Glu 
            740                 745                 750         


Thr Val Lys Ala Ala Glu Arg Ile Met Glu Ala Ile Glu Leu Tyr Arg 
        755                 760                 765             


Glu Glu Thr Ala Lys Met Lys Glu His Lys Ala Ile Cys Lys Ala Ala 
    770                 775                 780                 


Gly Lys Glu Val Pro Leu Pro Ser Asn Pro Ile Leu Met Ala Tyr Gly 
785                 790                 795                 800 


Ser Ile Ser Pro Ser Ala Tyr Val Leu Glu Ile Phe Lys Gly Ile Lys 
                805                 810                 815     


Ser Ser Glu Leu Glu Glu Ser Leu Leu Val Leu Pro Phe Ser Tyr Val 
            820                 825                 830         


Pro Asp Ile Leu Lys Leu Phe Asn Glu Phe Ile Gln Leu Gly Ser Asp 
        835                 840                 845             


Val Glu Leu Ile Cys Arg Cys Leu Phe Phe Leu Leu Arg Ile His Phe 
    850                 855                 860                 


Gly Gln Ile Thr Ser Asn Gln Met Leu Val Pro Val Ile Glu Lys Leu 
865                 870                 875                 880 


Arg Glu Thr Thr Ile Ser Lys Val Ser Gln Val Arg Asp Val Ile Gly 
                885                 890                 895     


Phe Asn Met Ala Gly Leu Asp Tyr Leu Lys Arg Glu Cys Glu Ala Lys 
            900                 905                 910         


Ser Glu Val Met Phe Phe Ala Asp Ala Thr Ser His Leu Glu Glu Lys 
        915                 920                 925             


Lys Arg Lys Arg Lys Lys Arg Glu Lys Leu Ile Leu Thr Leu Thr 
    930                 935                 940             


<210>  1421
<211>  7111
<212>  DNA
<213>  Homosapiens

<400>  1421
gcttaggcag ggcctgcgcc cagtttagag gccaatgctt ctcccgtcct ttgcatggca     60

cccaagaagg agaaaggagg aactgtgaac accagttcta agatatggga accctcgctc    120

atagctgcac agttcaatca gaacgattgg caggcctcca ttgcttttgt ggttgggaac    180

cagattgaag atgatcttct catccaagcc cttaccgtgg ctgtccaggt ccctcagcgt    240

aaactcttca gtatggtgtc gtggcaagac attctccagc agattaatga aataaataca    300

cttgttggat ctgcttcatc taaaaaggca aaaaaacctg taggtggtaa tgctccttta    360

tattatgagg tgttaacggc agcaaaagca attatggata gtggagagaa attaacctta    420

ccactgatag ggaaactctt gaaatttcaa cttctccaga ttaaatttaa ggaccaacag    480

cgacgggaaa atgaaaagaa ggtaatagaa gacaaaccta agttagaaaa ggataaaggg    540

aaagcaaaat ctcccaagga gaaaaaggct ccaagtgcca agcctgccaa aggaaaggga    600

aaggatcagc ctgaggcaaa tgcaccagtg aaaaagacca cccagttaaa gcggagagga    660

gaagacgacc acaccaatcg ttacattgac gatgagccag atgatggtgc ccaacattac    720

attatagttg tgggctttaa caatcctcag ctattagcaa ttatggctga gcttggcatt    780

cctataacca gcgtgattaa aatatcttca gagaattatg aacctctgca gacacacctg    840

gcagcagtta accagcagca ggaagttctt cttcagtcag aagatctaga agcagaaaaa    900

ttgaagaaag aaaatgccat aaaagagctt aaaactttct ggaagtactt ggaaccagtc    960

ctgaataatg agaaacctga aacaaatctc tttgatgttg ctcgacttga gtacatggtc   1020

aaagcagctg attttccttc tgactggtca gatggtgaga tgatgctgaa attgggcact   1080

gatatttttg aaaatattgc ctgcttgatg tatgacatcc tggattggaa aaggcagcac   1140

cagcactatt tggaaagcat gcagcttatt aatgttccac aagtggttaa tgagaaacct   1200

gtattagaag ccatgccaac ttcagaggct ccacaacctg ctgtaccagc tcctggaaag   1260

aagaaagcac agtatgaaga accgcaagct ccaccaccag tgacttcagt catcacaact   1320

gaagtagaca tgagatatta caattatttg ctgaatccaa ttcgagagga attcatttct   1380

gtgcccctga tactgcattg tatgctggaa caggttgttg caactgaaga agatctcgtc   1440

ccacccagtc tgcgggagcc atcccccaga gcagacgggc tagaccacag aatcgcagct   1500

cacattgtgt cccttctgcc ctcactctgt ctctcagaga gggagaaaaa gaatcttcat   1560

gacatatttt tatctgaaga agaaaatgaa agcaaagcag tgcccaaagg ccccctccta   1620

ctgaactatc atgatgcaca cgcccacaag aagtacgcac tacaggacca aaagaatttt   1680

gatccagttc aaattgagca ggagatgcag tccaagttgc cactgtggga atttcttcaa   1740

ttccctctac ccccaccatg gaacaacact aaacgtctag ctacaattca tgagcttatg   1800

cacttttgta cgagtgatgt cttgagctgg aatgaagtag aacgagcctt caaggtgttt   1860

acttttgaga gcctgaagct ctctgaggtt gatgaaaaag ggaaactgaa accttctggg   1920

atgatgtgtg ggtcagattc tgaaatgttc aacataccgt gggacaaccc tgccagattt   1980

gctaaacaga taaggcagca atatgtcatg aaaatgaata ctcaagaggc caagcagaaa   2040

gcagatatta aaatcaaaga cagaacacta tttgtggatc agaatttgtc aatgtctgtg   2100

caagataatg aaagcaaccg agaaccttca gatcctagtc agtgtgatgc taacaatatg   2160

aagcattctg acttgaataa tctcaaactc tcagtccctg ataatagaca gctgttagag   2220

caggagagca tcatgaaggc tcagccccaa catgagtctc tggagcagac cacaaacaat   2280

gagatcaaag atgatgcagt cacaaaggct gattctcatg aaaagaaacc caagaagatg   2340

atggtggaag cagatttaga ggacataaag aaaacacagc agcgcagtct aatggactgg   2400

agttttactg aacattttaa accgaaagta ctgcttcagg tccttcaaga agcccataag   2460

caatataggt gtgttgattc ttactaccac acccaagaca actctttact tttagtcttt   2520

cacaatccaa tgaatagaca acgtttgcat tgtgaatatt ggaacattgc tctccactcc   2580

aatgttggat tcaggaatta tttggaactt gttgcaaaat ctattcaaga ttggattaca   2640

aaagaagaag ctatatatca ggaatctaaa atgaatgaga aaatcatcag gaccagagct   2700

gagctggaat tgaaatcttc tgctaatgcc aaacttactt ctgctagcaa aattttttcc   2760

attaaagaat ctaaaagtaa caaaggaatc agcaaaacag agatatcaga tcaagaaaaa   2820

gaaaaagaga aggaaaagat tcctttcatt ttagaaggct ctctcaaggc atggaaagaa   2880

gagcaacatc gattagcaga agaggagcgc ttaagggaag aaaagaaagc agagaagaag   2940

ggtaaagaag ctggtaaaaa gaaaggcaag gataacgcag agaaagagga tagtaggtct   3000

ttgaagaaaa aatcacctta caaggagaaa tctaaagaag aacaagtcaa gatccaagaa   3060

gtaacagaag agtcccccca ccaaccagaa cctaagataa cttacccgtt tcacggatac   3120

aatatgggaa atatacccac tcaaatctca gggtcaaatt actacctgta tccttctgat   3180

ggggggcaga ttgaagtgga aaagacaatg tttgaaaaag gcccaacttt tatcaaagtg   3240

agagtggtaa aggacaacca caattttatg attcatttaa atgaccctaa ggaaattgtg   3300

aaaaaggaag agaaagggga ttattattta gaagaggaag aagaaggaga tgaggaacaa   3360

agtcttgaaa cggaagtatc agatgcaaag aataaagctt tcagcaagtt tggatctttt   3420

tctgccacct tagaaaatgg aatctgcctc tcgataagtt actatggatc aaatggaatg   3480

gcaccagaag ataaggatcc tgatttagaa acaatattga atatcccttc agcactcact   3540

ccaacagtgg ttcctgttat agtgaccgtt cctcaaagca aagctaaagg gaaaataaaa   3600

ggcaaagaaa aacccaaaga atcccttaaa gaagaagaac acccaaaaga agaagagaaa   3660

aaggaagaag aagtagaacc agaacctgtt ttacaagaga ctttggatgt tcccaccttc   3720

cagagcctaa atgtgtcttg ccccagtggg ctcctgttga ctttcattgg acaagaatct   3780

acaggtcaat atgttataga tgaggaaccc acctgggaca tcatggtccg tcagagctac   3840

ccccagaggg tgaagcacta tgagttctat aaaacggtga tgccacccgc agagcaggag   3900

gcttcaaggg ttatcaccag tcaaggcact gttgtcaaat atatgttgga tggatccaca   3960

cagattctct ttgcagatgg tgctgtgagc aggagtccca attcaggtct tatttgtcct   4020

ccttctgaaa tgccagcaac gcctcacagt ggagatttga tggactctat ttctcagcag   4080

aaatcagaaa cgataccatc tgagattacc aacacaaaga aaggaaaaag tcacaaaagt   4140

cagtcatcaa tggcccataa gggtgaaatc catgaccctc ctccagaggc agttcaaact   4200

gtaactcctg tggaggttca cataggcacc tggtttacaa ccacacctga aggaaatcgg   4260

atcggcacca aaggattaga aagaatagca gacttgaccc cattgttatc ctttcaggcc   4320

acagatcctg tcaatggaac ggttatgaca actcgagaag acaaagttgt catagttgaa   4380

aggaaagatg gtactcggat agtggatcat gctgatggta ccagaatcac aaccttttat   4440

caagtttatg aagatcaaat tattctgcca gatgatcaag aaacaaccga gggtcctcgg   4500

actgtcacca ggcaggtgaa gtgtatgcgg gtagaaagct cacgctatgc cactgttatc   4560

gccaactgtg aggacagtag ctgctgtgcc acctttggag atggaacaac tattattgca   4620

aagccacagg gaacatacca ggtgttacct ccaaacacag gctctcttta tattgacaag   4680

gattgttcag ctgtgtactg ccatgagtca agcagtaata tatactatcc ttttcaaaag   4740

cgtgagcagc tgcgagctgg caggtacatc atgaggcata cttcagaggt tatctgtgag   4800

gttctggatc ctgagggaaa cacttttcag gtcatggctg atggtagcat atcaactata   4860

ttacctgaaa aaaaattgga agatgattta aatgagaaaa ctgagggcta tgatagtctg   4920

tcctctatgc accttgaaaa gaatcatcag caaatctatg gtgaacatgt ccccaggttt   4980

tttgttatgt atgctgatgg atcaggaatg gaacttcttc gagacagtga catagaagaa   5040

tatctatctt tggcatataa agaatcaaat actgttgttc tccaagagcc agtgcaggaa   5100

cagccaggca ccctaaccat cacagtcctt cgccctttcc atgaagcatc accatggcaa   5160

gtaaaaaagg aagatacaat tgtccctcct aatctccggt caaggtcatg ggaaacattt   5220

ccctcagttg agaaaaaaac tccaggacct ccgtttggta ctcagatttg gaaaggcctt   5280

tgcattgagt ccaaacagct agtgagtgcc ccgggtgcca tactcaagag ccccagtgtg   5340

ctacagatgc gccaattcat tcagcatgag gtcataaaga atgaggtgaa actgaggctg   5400

caggtttccc ttaaggatta cataaactat attctaaaga aagaagatga gctgcaggaa   5460

atgatggtta aagattccag aactgaggag gagagaggca atgctgctga tctcctcaag   5520

ctggttatgt ctttccctaa aatggaggaa actacaaaaa gtcatgttac tgaagttgca   5580

gctcacctaa ctgatttatt caagcagtct ttggctacgc ctccaaaatg cccaccagac   5640

acatttggta aagatttctt tgaaaagaca tggagacaca cagcatcctc aaaacgctgg   5700

aaagaaaaga tagacaaaac gaggaaggaa attgagacaa cacagaatta cctaatggat   5760

attaagaacc gcataatacc accctttttt aaatctgaat tgaaccagtt atatcagtct   5820

cagtataatc acctggacag tctttccaaa aaactgcctt cttttacaaa gaaaaatgaa   5880

gatgcaaacg aaacagctgt tcaagataca tctgatctta atctagattt caagccacat   5940

aaggtttcag aacagaaatc ctcaagtgtg cctagtcttc caaaaccaga gatttctgca   6000

gataagaagg atttcactgc tcagaaccaa actgaaaatt taacaaaatc tcctgaagaa   6060

gcagaatctt atgagcccgt gaaaattcca acccagtcct tgctgcagga tgttgcggga   6120

caaacaagaa aagaaaaagt gaagttgcct cattatttgc tgagttccaa gcctaagtct   6180

caacctcttg caaaggtgca agattctgtt ggaggaaaag tgaacacatc ctctgttgca   6240

tctgctgcca ttaataatgc aaagtcatcc ctttttgggt tccatcttct cccatcatca   6300

gtcaagtttg gagtgcttaa ggaaggacat acctatgcca cagttgtaaa gctcaagaat   6360

gttggagtgg acttctgcag gtttaaagta aagcagcccc cacccagcac aggactgaaa   6420

gtgacttaca aacctggacc tgtggcagct ggtatgcaga cagaactgaa tatagagtta   6480

tttgccacag ctgttggaga ggatggggcc aagggatcag cacacatctc tcacaatatc   6540

gagattatga cagagcatga ggttctgttc ctacctgtgg aagcaactgt tttaacaagc   6600

agcaattatg ataaacgacc aaaagacttt ccccagggaa aagaaaatcc aatggtccag   6660

agaacttcta caatttattc ctccacactt ggagtcttca tgtctcgtaa agtttctcca   6720

cattagtttc ttctcggtac aactcaatag cctccataat cctctcagcc tacagaggat   6780

gagaaaggaa agaagtcatc acaacatact ccatcatccc aggacactga aactggaaga   6840

actgaccaga aatttgccaa atgaaatagc ttcaatctgt ttaataaaga cgtgcgaata   6900

gagtgccaaa aagcatttaa agacattttt ggttttctta ttttttaatg tacagggaag   6960

agactgagtg tcatggactc aggtgggatg atatctagac actctgaata gggcaggtcc   7020

caggaacacc tgaaaggagc acatattgat caaagagatt caggactact cccatctttg   7080

gttacaagag aaggaaacag gttataatcc c                                  7111


<210>  1422
<211>  2223
<212>  PRT
<213>  Homosapiens

<400>  1422

Met Ala Pro Lys Lys Glu Lys Gly Gly Thr Val Asn Thr Ser Ser Lys 
1               5                   10                  15      


Ile Trp Glu Pro Ser Leu Ile Ala Ala Gln Phe Asn Gln Asn Asp Trp 
            20                  25                  30          


Gln Ala Ser Ile Ala Phe Val Val Gly Asn Gln Ile Glu Asp Asp Leu 
        35                  40                  45              


Leu Ile Gln Ala Leu Thr Val Ala Val Gln Val Pro Gln Arg Lys Leu 
    50                  55                  60                  


Phe Ser Met Val Ser Trp Gln Asp Ile Leu Gln Gln Ile Asn Glu Ile 
65                  70                  75                  80  


Asn Thr Leu Val Gly Ser Ala Ser Ser Lys Lys Ala Lys Lys Pro Val 
                85                  90                  95      


Gly Gly Asn Ala Pro Leu Tyr Tyr Glu Val Leu Thr Ala Ala Lys Ala 
            100                 105                 110         


Ile Met Asp Ser Gly Glu Lys Leu Thr Leu Pro Leu Ile Gly Lys Leu 
        115                 120                 125             


Leu Lys Phe Gln Leu Leu Gln Ile Lys Phe Lys Asp Gln Gln Arg Arg 
    130                 135                 140                 


Glu Asn Glu Lys Lys Val Ile Glu Asp Lys Pro Lys Leu Glu Lys Asp 
145                 150                 155                 160 


Lys Gly Lys Ala Lys Ser Pro Lys Glu Lys Lys Ala Pro Ser Ala Lys 
                165                 170                 175     


Pro Ala Lys Gly Lys Gly Lys Asp Gln Pro Glu Ala Asn Ala Pro Val 
            180                 185                 190         


Lys Lys Thr Thr Gln Leu Lys Arg Arg Gly Glu Asp Asp His Thr Asn 
        195                 200                 205             


Arg Tyr Ile Asp Asp Glu Pro Asp Asp Gly Ala Gln His Tyr Ile Ile 
    210                 215                 220                 


Val Val Gly Phe Asn Asn Pro Gln Leu Leu Ala Ile Met Ala Glu Leu 
225                 230                 235                 240 


Gly Ile Pro Ile Thr Ser Val Ile Lys Ile Ser Ser Glu Asn Tyr Glu 
                245                 250                 255     


Pro Leu Gln Thr His Leu Ala Ala Val Asn Gln Gln Gln Glu Val Leu 
            260                 265                 270         


Leu Gln Ser Glu Asp Leu Glu Ala Glu Lys Leu Lys Lys Glu Asn Ala 
        275                 280                 285             


Ile Lys Glu Leu Lys Thr Phe Trp Lys Tyr Leu Glu Pro Val Leu Asn 
    290                 295                 300                 


Asn Glu Lys Pro Glu Thr Asn Leu Phe Asp Val Ala Arg Leu Glu Tyr 
305                 310                 315                 320 


Met Val Lys Ala Ala Asp Phe Pro Ser Asp Trp Ser Asp Gly Glu Met 
                325                 330                 335     


Met Leu Lys Leu Gly Thr Asp Ile Phe Glu Asn Ile Ala Cys Leu Met 
            340                 345                 350         


Tyr Asp Ile Leu Asp Trp Lys Arg Gln His Gln His Tyr Leu Glu Ser 
        355                 360                 365             


Met Gln Leu Ile Asn Val Pro Gln Val Val Asn Glu Lys Pro Val Leu 
    370                 375                 380                 


Glu Ala Met Pro Thr Ser Glu Ala Pro Gln Pro Ala Val Pro Ala Pro 
385                 390                 395                 400 


Gly Lys Lys Lys Ala Gln Tyr Glu Glu Pro Gln Ala Pro Pro Pro Val 
                405                 410                 415     


Thr Ser Val Ile Thr Thr Glu Val Asp Met Arg Tyr Tyr Asn Tyr Leu 
            420                 425                 430         


Leu Asn Pro Ile Arg Glu Glu Phe Ile Ser Val Pro Leu Ile Leu His 
        435                 440                 445             


Cys Met Leu Glu Gln Val Val Ala Thr Glu Glu Asp Leu Val Pro Pro 
    450                 455                 460                 


Ser Leu Arg Glu Pro Ser Pro Arg Ala Asp Gly Leu Asp His Arg Ile 
465                 470                 475                 480 


Ala Ala His Ile Val Ser Leu Leu Pro Ser Leu Cys Leu Ser Glu Arg 
                485                 490                 495     


Glu Lys Lys Asn Leu His Asp Ile Phe Leu Ser Glu Glu Glu Asn Glu 
            500                 505                 510         


Ser Lys Ala Val Pro Lys Gly Pro Leu Leu Leu Asn Tyr His Asp Ala 
        515                 520                 525             


His Ala His Lys Lys Tyr Ala Leu Gln Asp Gln Lys Asn Phe Asp Pro 
    530                 535                 540                 


Val Gln Ile Glu Gln Glu Met Gln Ser Lys Leu Pro Leu Trp Glu Phe 
545                 550                 555                 560 


Leu Gln Phe Pro Leu Pro Pro Pro Trp Asn Asn Thr Lys Arg Leu Ala 
                565                 570                 575     


Thr Ile His Glu Leu Met His Phe Cys Thr Ser Asp Val Leu Ser Trp 
            580                 585                 590         


Asn Glu Val Glu Arg Ala Phe Lys Val Phe Thr Phe Glu Ser Leu Lys 
        595                 600                 605             


Leu Ser Glu Val Asp Glu Lys Gly Lys Leu Lys Pro Ser Gly Met Met 
    610                 615                 620                 


Cys Gly Ser Asp Ser Glu Met Phe Asn Ile Pro Trp Asp Asn Pro Ala 
625                 630                 635                 640 


Arg Phe Ala Lys Gln Ile Arg Gln Gln Tyr Val Met Lys Met Asn Thr 
                645                 650                 655     


Gln Glu Ala Lys Gln Lys Ala Asp Ile Lys Ile Lys Asp Arg Thr Leu 
            660                 665                 670         


Phe Val Asp Gln Asn Leu Ser Met Ser Val Gln Asp Asn Glu Ser Asn 
        675                 680                 685             


Arg Glu Pro Ser Asp Pro Ser Gln Cys Asp Ala Asn Asn Met Lys His 
    690                 695                 700                 


Ser Asp Leu Asn Asn Leu Lys Leu Ser Val Pro Asp Asn Arg Gln Leu 
705                 710                 715                 720 


Leu Glu Gln Glu Ser Ile Met Lys Ala Gln Pro Gln His Glu Ser Leu 
                725                 730                 735     


Glu Gln Thr Thr Asn Asn Glu Ile Lys Asp Asp Ala Val Thr Lys Ala 
            740                 745                 750         


Asp Ser His Glu Lys Lys Pro Lys Lys Met Met Val Glu Ala Asp Leu 
        755                 760                 765             


Glu Asp Ile Lys Lys Thr Gln Gln Arg Ser Leu Met Asp Trp Ser Phe 
    770                 775                 780                 


Thr Glu His Phe Lys Pro Lys Val Leu Leu Gln Val Leu Gln Glu Ala 
785                 790                 795                 800 


His Lys Gln Tyr Arg Cys Val Asp Ser Tyr Tyr His Thr Gln Asp Asn 
                805                 810                 815     


Ser Leu Leu Leu Val Phe His Asn Pro Met Asn Arg Gln Arg Leu His 
            820                 825                 830         


Cys Glu Tyr Trp Asn Ile Ala Leu His Ser Asn Val Gly Phe Arg Asn 
        835                 840                 845             


Tyr Leu Glu Leu Val Ala Lys Ser Ile Gln Asp Trp Ile Thr Lys Glu 
    850                 855                 860                 


Glu Ala Ile Tyr Gln Glu Ser Lys Met Asn Glu Lys Ile Ile Arg Thr 
865                 870                 875                 880 


Arg Ala Glu Leu Glu Leu Lys Ser Ser Ala Asn Ala Lys Leu Thr Ser 
                885                 890                 895     


Ala Ser Lys Ile Phe Ser Ile Lys Glu Ser Lys Ser Asn Lys Gly Ile 
            900                 905                 910         


Ser Lys Thr Glu Ile Ser Asp Gln Glu Lys Glu Lys Glu Lys Glu Lys 
        915                 920                 925             


Ile Pro Phe Ile Leu Glu Gly Ser Leu Lys Ala Trp Lys Glu Glu Gln 
    930                 935                 940                 


His Arg Leu Ala Glu Glu Glu Arg Leu Arg Glu Glu Lys Lys Ala Glu 
945                 950                 955                 960 


Lys Lys Gly Lys Glu Ala Gly Lys Lys Lys Gly Lys Asp Asn Ala Glu 
                965                 970                 975     


Lys Glu Asp Ser Arg Ser Leu Lys Lys Lys Ser Pro Tyr Lys Glu Lys 
            980                 985                 990         


Ser Lys Glu Glu Gln Val Lys Ile  Gln Glu Val Thr Glu  Glu Ser Pro 
        995                 1000                 1005             


His Gln  Pro Glu Pro Lys Ile  Thr Tyr Pro Phe His  Gly Tyr Asn 
    1010                 1015                 1020             


Met Gly  Asn Ile Pro Thr Gln  Ile Ser Gly Ser Asn  Tyr Tyr Leu 
    1025                 1030                 1035             


Tyr Pro  Ser Asp Gly Gly Gln  Ile Glu Val Glu Lys  Thr Met Phe 
    1040                 1045                 1050             


Glu Lys  Gly Pro Thr Phe Ile  Lys Val Arg Val Val  Lys Asp Asn 
    1055                 1060                 1065             


His Asn  Phe Met Ile His Leu  Asn Asp Pro Lys Glu  Ile Val Lys 
    1070                 1075                 1080             


Lys Glu  Glu Lys Gly Asp Tyr  Tyr Leu Glu Glu Glu  Glu Glu Gly 
    1085                 1090                 1095             


Asp Glu  Glu Gln Ser Leu Glu  Thr Glu Val Ser Asp  Ala Lys Asn 
    1100                 1105                 1110             


Lys Ala  Phe Ser Lys Phe Gly  Ser Phe Ser Ala Thr  Leu Glu Asn 
    1115                 1120                 1125             


Gly Ile  Cys Leu Ser Ile Ser  Tyr Tyr Gly Ser Asn  Gly Met Ala 
    1130                 1135                 1140             


Pro Glu  Asp Lys Asp Pro Asp  Leu Glu Thr Ile Leu  Asn Ile Pro 
    1145                 1150                 1155             


Ser Ala  Leu Thr Pro Thr Val  Val Pro Val Ile Val  Thr Val Pro 
    1160                 1165                 1170             


Gln Ser  Lys Ala Lys Gly Lys  Ile Lys Gly Lys Glu  Lys Pro Lys 
    1175                 1180                 1185             


Glu Ser  Leu Lys Glu Glu Glu  His Pro Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Val Glu Pro Glu  Pro Val Leu Gln Glu  Thr Leu Asp 
    1205                 1210                 1215             


Val Pro  Thr Phe Gln Ser Leu  Asn Val Ser Cys Pro  Ser Gly Leu 
    1220                 1225                 1230             


Leu Leu  Thr Phe Ile Gly Gln  Glu Ser Thr Gly Gln  Tyr Val Ile 
    1235                 1240                 1245             


Asp Glu  Glu Pro Thr Trp Asp  Ile Met Val Arg Gln  Ser Tyr Pro 
    1250                 1255                 1260             


Gln Arg  Val Lys His Tyr Glu  Phe Tyr Lys Thr Val  Met Pro Pro 
    1265                 1270                 1275             


Ala Glu  Gln Glu Ala Ser Arg  Val Ile Thr Ser Gln  Gly Thr Val 
    1280                 1285                 1290             


Val Lys  Tyr Met Leu Asp Gly  Ser Thr Gln Ile Leu  Phe Ala Asp 
    1295                 1300                 1305             


Gly Ala  Val Ser Arg Ser Pro  Asn Ser Gly Leu Ile  Cys Pro Pro 
    1310                 1315                 1320             


Ser Glu  Met Pro Ala Thr Pro  His Ser Gly Asp Leu  Met Asp Ser 
    1325                 1330                 1335             


Ile Ser  Gln Gln Lys Ser Glu  Thr Ile Pro Ser Glu  Ile Thr Asn 
    1340                 1345                 1350             


Thr Lys  Lys Gly Lys Ser His  Lys Ser Gln Ser Ser  Met Ala His 
    1355                 1360                 1365             


Lys Gly  Glu Ile His Asp Pro  Pro Pro Glu Ala Val  Gln Thr Val 
    1370                 1375                 1380             


Thr Pro  Val Glu Val His Ile  Gly Thr Trp Phe Thr  Thr Thr Pro 
    1385                 1390                 1395             


Glu Gly  Asn Arg Ile Gly Thr  Lys Gly Leu Glu Arg  Ile Ala Asp 
    1400                 1405                 1410             


Leu Thr  Pro Leu Leu Ser Phe  Gln Ala Thr Asp Pro  Val Asn Gly 
    1415                 1420                 1425             


Thr Val  Met Thr Thr Arg Glu  Asp Lys Val Val Ile  Val Glu Arg 
    1430                 1435                 1440             


Lys Asp  Gly Thr Arg Ile Val  Asp His Ala Asp Gly  Thr Arg Ile 
    1445                 1450                 1455             


Thr Thr  Phe Tyr Gln Val Tyr  Glu Asp Gln Ile Ile  Leu Pro Asp 
    1460                 1465                 1470             


Asp Gln  Glu Thr Thr Glu Gly  Pro Arg Thr Val Thr  Arg Gln Val 
    1475                 1480                 1485             


Lys Cys  Met Arg Val Glu Ser  Ser Arg Tyr Ala Thr  Val Ile Ala 
    1490                 1495                 1500             


Asn Cys  Glu Asp Ser Ser Cys  Cys Ala Thr Phe Gly  Asp Gly Thr 
    1505                 1510                 1515             


Thr Ile  Ile Ala Lys Pro Gln  Gly Thr Tyr Gln Val  Leu Pro Pro 
    1520                 1525                 1530             


Asn Thr  Gly Ser Leu Tyr Ile  Asp Lys Asp Cys Ser  Ala Val Tyr 
    1535                 1540                 1545             


Cys His  Glu Ser Ser Ser Asn  Ile Tyr Tyr Pro Phe  Gln Lys Arg 
    1550                 1555                 1560             


Glu Gln  Leu Arg Ala Gly Arg  Tyr Ile Met Arg His  Thr Ser Glu 
    1565                 1570                 1575             


Val Ile  Cys Glu Val Leu Asp  Pro Glu Gly Asn Thr  Phe Gln Val 
    1580                 1585                 1590             


Met Ala  Asp Gly Ser Ile Ser  Thr Ile Leu Pro Glu  Lys Lys Leu 
    1595                 1600                 1605             


Glu Asp  Asp Leu Asn Glu Lys  Thr Glu Gly Tyr Asp  Ser Leu Ser 
    1610                 1615                 1620             


Ser Met  His Leu Glu Lys Asn  His Gln Gln Ile Tyr  Gly Glu His 
    1625                 1630                 1635             


Val Pro  Arg Phe Phe Val Met  Tyr Ala Asp Gly Ser  Gly Met Glu 
    1640                 1645                 1650             


Leu Leu  Arg Asp Ser Asp Ile  Glu Glu Tyr Leu Ser  Leu Ala Tyr 
    1655                 1660                 1665             


Lys Glu  Ser Asn Thr Val Val  Leu Gln Glu Pro Val  Gln Glu Gln 
    1670                 1675                 1680             


Pro Gly  Thr Leu Thr Ile Thr  Val Leu Arg Pro Phe  His Glu Ala 
    1685                 1690                 1695             


Ser Pro  Trp Gln Val Lys Lys  Glu Asp Thr Ile Val  Pro Pro Asn 
    1700                 1705                 1710             


Leu Arg  Ser Arg Ser Trp Glu  Thr Phe Pro Ser Val  Glu Lys Lys 
    1715                 1720                 1725             


Thr Pro  Gly Pro Pro Phe Gly  Thr Gln Ile Trp Lys  Gly Leu Cys 
    1730                 1735                 1740             


Ile Glu  Ser Lys Gln Leu Val  Ser Ala Pro Gly Ala  Ile Leu Lys 
    1745                 1750                 1755             


Ser Pro  Ser Val Leu Gln Met  Arg Gln Phe Ile Gln  His Glu Val 
    1760                 1765                 1770             


Ile Lys  Asn Glu Val Lys Leu  Arg Leu Gln Val Ser  Leu Lys Asp 
    1775                 1780                 1785             


Tyr Ile  Asn Tyr Ile Leu Lys  Lys Glu Asp Glu Leu  Gln Glu Met 
    1790                 1795                 1800             


Met Val  Lys Asp Ser Arg Thr  Glu Glu Glu Arg Gly  Asn Ala Ala 
    1805                 1810                 1815             


Asp Leu  Leu Lys Leu Val Met  Ser Phe Pro Lys Met  Glu Glu Thr 
    1820                 1825                 1830             


Thr Lys  Ser His Val Thr Glu  Val Ala Ala His Leu  Thr Asp Leu 
    1835                 1840                 1845             


Phe Lys  Gln Ser Leu Ala Thr  Pro Pro Lys Cys Pro  Pro Asp Thr 
    1850                 1855                 1860             


Phe Gly  Lys Asp Phe Phe Glu  Lys Thr Trp Arg His  Thr Ala Ser 
    1865                 1870                 1875             


Ser Lys  Arg Trp Lys Glu Lys  Ile Asp Lys Thr Arg  Lys Glu Ile 
    1880                 1885                 1890             


Glu Thr  Thr Gln Asn Tyr Leu  Met Asp Ile Lys Asn  Arg Ile Ile 
    1895                 1900                 1905             


Pro Pro  Phe Phe Lys Ser Glu  Leu Asn Gln Leu Tyr  Gln Ser Gln 
    1910                 1915                 1920             


Tyr Asn  His Leu Asp Ser Leu  Ser Lys Lys Leu Pro  Ser Phe Thr 
    1925                 1930                 1935             


Lys Lys  Asn Glu Asp Ala Asn  Glu Thr Ala Val Gln  Asp Thr Ser 
    1940                 1945                 1950             


Asp Leu  Asn Leu Asp Phe Lys  Pro His Lys Val Ser  Glu Gln Lys 
    1955                 1960                 1965             


Ser Ser  Ser Val Pro Ser Leu  Pro Lys Pro Glu Ile  Ser Ala Asp 
    1970                 1975                 1980             


Lys Lys  Asp Phe Thr Ala Gln  Asn Gln Thr Glu Asn  Leu Thr Lys 
    1985                 1990                 1995             


Ser Pro  Glu Glu Ala Glu Ser  Tyr Glu Pro Val Lys  Ile Pro Thr 
    2000                 2005                 2010             


Gln Ser  Leu Leu Gln Asp Val  Ala Gly Gln Thr Arg  Lys Glu Lys 
    2015                 2020                 2025             


Val Lys  Leu Pro His Tyr Leu  Leu Ser Ser Lys Pro  Lys Ser Gln 
    2030                 2035                 2040             


Pro Leu  Ala Lys Val Gln Asp  Ser Val Gly Gly Lys  Val Asn Thr 
    2045                 2050                 2055             


Ser Ser  Val Ala Ser Ala Ala  Ile Asn Asn Ala Lys  Ser Ser Leu 
    2060                 2065                 2070             


Phe Gly  Phe His Leu Leu Pro  Ser Ser Val Lys Phe  Gly Val Leu 
    2075                 2080                 2085             


Lys Glu  Gly His Thr Tyr Ala  Thr Val Val Lys Leu  Lys Asn Val 
    2090                 2095                 2100             


Gly Val  Asp Phe Cys Arg Phe  Lys Val Lys Gln Pro  Pro Pro Ser 
    2105                 2110                 2115             


Thr Gly  Leu Lys Val Thr Tyr  Lys Pro Gly Pro Val  Ala Ala Gly 
    2120                 2125                 2130             


Met Gln  Thr Glu Leu Asn Ile  Glu Leu Phe Ala Thr  Ala Val Gly 
    2135                 2140                 2145             


Glu Asp  Gly Ala Lys Gly Ser  Ala His Ile Ser His  Asn Ile Glu 
    2150                 2155                 2160             


Ile Met  Thr Glu His Glu Val  Leu Phe Leu Pro Val  Glu Ala Thr 
    2165                 2170                 2175             


Val Leu  Thr Ser Ser Asn Tyr  Asp Lys Arg Pro Lys  Asp Phe Pro 
    2180                 2185                 2190             


Gln Gly  Lys Glu Asn Pro Met  Val Gln Arg Thr Ser  Thr Ile Tyr 
    2195                 2200                 2205             


Ser Ser  Thr Leu Gly Val Phe  Met Ser Arg Lys Val  Ser Pro His 
    2210                 2215                 2220             


<210>  1423
<211>  4176
<212>  DNA
<213>  Homosapiens

<400>  1423
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt     60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac    120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc    180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag    240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct    300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc    360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg    420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg    480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc    540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca    600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg    660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt    720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg    780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg    840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga    900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct    960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg   1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc   1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca   1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc   1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc   1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc   1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt   1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta   1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc   1500

cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg   1560

ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc   1620

gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc   1680

cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca   1740

gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga   1800

gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc   1860

agcagcctgg accctgtgga tgataaaaca caaacgggct cagcaaaaga tgcttctcac   1920

tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga   1980

aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa   2040

cctccctttc caaatgccca gcttaaaggg gctagagtga acttgggcca ctgtgaagag   2100

aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg   2160

gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca   2220

ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc   2280

ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgcct tagcaaattc   2340

tgtttttcta ggcctgggga cggcttttac ttaaaccgcc aaggctgggg gaagaagctc   2400

tctcctccct ttcttcccta cagttgaaaa acagctgagg gtgagtgggt gaataataca   2460

gtatctcagg gcctggtcgt tttcaacaga attataatta gttcctcatt agcattttgc   2520

taaatgtgaa tgatgatcct aggcatttgc tgaatacaga ggcaactgca ttggctttgg   2580

gttgcaggac ctcaggtgag aagcagagga aggagaggag aggggcacag ggtctctacc   2640

atcccctgta gagtgggagc tgagtggggg atcacagcct ctgaaaacca atgttctctc   2700

ttctccacct cccacaaagg agagctagca gcagggaggg cttctgccat ttctgagatc   2760

aaaacggttt tactgcagct ttgtttgttg tcagctgaac ctgggtaact agggaagata   2820

atattaagga agacaatgtg aaaagaaaaa tgagcctggc aagaatgtgt ttaaacttgg   2880

tttttaaaaa actgctgact gttttctctt gagagggtgg aatatccaat attcgctgtg   2940

tcagcataga agtaacttac ttaggtgtgg gggaagcacc ataactttgt ttagcccaaa   3000

accaagtcaa gtgaaaaagg aggaagagaa aaaatatttt cctgccaggc atggtggccc   3060

acgcacttcg ggaggtcgag gcaggaggat cacttgagtc cagaagtttg agatcagcct   3120

gggcaatgtg ataaaacccc atctctacaa aaagcataaa aattagccaa gtgtggtaga   3180

gtgtgcctga agtcccagat acttgggggg ctgaggtggg aggatctctt gagcctggga   3240

ggtcaaggct gcagtgagcc gagattgcac cactgcactc cagcctgggt gacagagcaa   3300

gtgagaccct gtctcaaaaa aagaaaaaga aaaagaaaaa atattttccc tattagagaa   3360

gagattgtgg tttcattctg tattttgttt ttgtcttaaa aagtggaaaa atagcctgcc   3420

tcttctctac tctagggaaa aaccagcgtg tgactactcc cccaggtggt tatggagagg   3480

gtgtccggtc cctgtcccag tgccgagaag gaagcctccc acgactgccc ggcagggtcc   3540

tagaaattcc ccaccctgaa agccctgagc tttctgctat caaagaggtt ttaaaaaaat   3600

cccatttaaa aaaaatccct tacctcggtg ccttcctctt tttatttagt tccttgagtt   3660

gattcagctc tgcaagaatt gaagcaggac taaatgtcta gttgtaacac catgattaac   3720

cacttcagct gacttttctg tccgagcttt gaaaattcag tggtgttagt ggttacccag   3780

ttagctctca agttatcagg gtattccaga gtggggatat gatttaaatc agccgtgtaa   3840

ccatggaccc aatatttacc agaccacaaa acttttctaa tactctaccc tcttagaaaa   3900

accaccacca tcaccagaca ggtgcgaaag gatgaaagtg accatgtttt gtttacggtt   3960

ttccaggttt aagctgttac tgtcttcagt aagccgtgat tttcattgct gggcttgtct   4020

gtagatttta gaccctattg ctgcttgagg caactcatct taggttggca aaaaggcagg   4080

atggccgggc gcggtggctc acgcctgtaa tcctagcact ttgggaggcc aaggtgggag   4140

gattgcttga gctcaggagt ttgagaccaa cctggg                             4176


<210>  1424
<211>  468
<212>  PRT
<213>  Homosapiens

<400>  1424

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  1425
<211>  4082
<212>  DNA
<213>  Homosapiens

<400>  1425
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt     60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac    120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc    180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag    240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct    300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc    360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg    420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg    480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc    540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca    600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg    660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt    720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg    780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg    840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga    900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct    960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg   1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc   1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca   1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc   1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc   1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc   1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt   1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta   1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc   1500

caggttcaag aagacgtgga agctgcgggc tctgaaggaa ggcaagacaa gcatgcatcc   1560

gccgtactct ttggggcagc tggtcccgga gaggcctcga cccaccccag tgcttgttcc   1620

tctcatctcc ccaccggtgt cccccagcag cctggggtct gacaatacct cgagccacaa   1680

ccgaccagat gccagggacc cacggagccc ttatgacatc agcaatacag actacttctt   1740

ccccagatag ctggctgggt ggcaccagca gcctggaccc tgtggatgat aaaacacaaa   1800

cgggctcagc aaaagatgct tctcactgcc atgccagctt atctcagggg tgtgcggcct   1860

ttggcttcac ggaagagcct tgcggaaggt tctacgccag gggaaaatca gcctgctcca   1920

gctgttcagc tggttgaggt ttcaaacctc cctttccaaa tgcccagctt aaaggggcta   1980

gagtgaactt gggccactgt gaagagaacc atatcaagac tctttggaca ctcacacgga   2040

cactcaaaag ctgggcaggt tggtgggggc ctcggtgtgg agaagcggct ggcagcccac   2100

ccctcaacac ctctgcacaa gctgcaccct caggcaggtg ggatggattt ccagccaaag   2160

cctcctccag ccgccatgct cctggcccac tgcatcgttt catcttccaa ctcaaactct   2220

taaaacccaa gtgccttagc aaattctgtt tttctaggcc tggggacggc ttttacttaa   2280

accgccaagg ctgggggaag aagctctctc ctccctttct tccctacagt tgaaaaacag   2340

ctgagggtga gtgggtgaat aatacagtat ctcagggcct ggtcgttttc aacagaatta   2400

taattagttc ctcattagca ttttgctaaa tgtgaatgat gatcctaggc atttgctgaa   2460

tacagaggca actgcattgg ctttgggttg caggacctca ggtgagaagc agaggaagga   2520

gaggagaggg gcacagggtc tctaccatcc cctgtagagt gggagctgag tgggggatca   2580

cagcctctga aaaccaatgt tctctcttct ccacctccca caaaggagag ctagcagcag   2640

ggagggcttc tgccatttct gagatcaaaa cggttttact gcagctttgt ttgttgtcag   2700

ctgaacctgg gtaactaggg aagataatat taaggaagac aatgtgaaaa gaaaaatgag   2760

cctggcaaga atgtgtttaa acttggtttt taaaaaactg ctgactgttt tctcttgaga   2820

gggtggaata tccaatattc gctgtgtcag catagaagta acttacttag gtgtggggga   2880

agcaccataa ctttgtttag cccaaaacca agtcaagtga aaaaggagga agagaaaaaa   2940

tattttcctg ccaggcatgg tggcccacgc acttcgggag gtcgaggcag gaggatcact   3000

tgagtccaga agtttgagat cagcctgggc aatgtgataa aaccccatct ctacaaaaag   3060

cataaaaatt agccaagtgt ggtagagtgt gcctgaagtc ccagatactt ggggggctga   3120

ggtgggagga tctcttgagc ctgggaggtc aaggctgcag tgagccgaga ttgcaccact   3180

gcactccagc ctgggtgaca gagcaagtga gaccctgtct caaaaaaaga aaaagaaaaa   3240

gaaaaaatat tttccctatt agagaagaga ttgtggtttc attctgtatt ttgtttttgt   3300

cttaaaaagt ggaaaaatag cctgcctctt ctctactcta gggaaaaacc agcgtgtgac   3360

tactccccca ggtggttatg gagagggtgt ccggtccctg tcccagtgcc gagaaggaag   3420

cctcccacga ctgcccggca gggtcctaga aattccccac cctgaaagcc ctgagctttc   3480

tgctatcaaa gaggttttaa aaaaatccca tttaaaaaaa atcccttacc tcggtgcctt   3540

cctcttttta tttagttcct tgagttgatt cagctctgca agaattgaag caggactaaa   3600

tgtctagttg taacaccatg attaaccact tcagctgact tttctgtccg agctttgaaa   3660

attcagtggt gttagtggtt acccagttag ctctcaagtt atcagggtat tccagagtgg   3720

ggatatgatt taaatcagcc gtgtaaccat ggacccaata tttaccagac cacaaaactt   3780

ttctaatact ctaccctctt agaaaaacca ccaccatcac cagacaggtg cgaaaggatg   3840

aaagtgacca tgttttgttt acggttttcc aggtttaagc tgttactgtc ttcagtaagc   3900

cgtgattttc attgctgggc ttgtctgtag attttagacc ctattgctgc ttgaggcaac   3960

tcatcttagg ttggcaaaaa ggcaggatgg ccgggcgcgg tggctcacgc ctgtaatcct   4020

agcactttgg gaggccaagg tgggaggatt gcttgagctc aggagtttga gaccaacctg   4080

gg                                                                  4082


<210>  1426
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  1426

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 


<210>  1427
<211>  6243
<212>  DNA
<213>  Homosapiens

<400>  1427
gccgggcgtg ggcgacggcc ggccgggggc gcacggagca gccgtcgcgg ggcctcgccg     60

cggcctccag cgccccagtc acggggaatg cagtggtccc cgacccctgg cgcctctgcg    120

tgtctgggct gggcttcctc gctcgcctgc tccacggccc cgacgctcct gggccgagcc    180

ggccggggcc ccctcatggc ggccaagtgg ttcaaggagt tccccctgaa cctgaagacc    240

gtgtcggagc gggccaagcc cgggggcggc ggcggcaaat tgcgcaagaa ctcggaggcg    300

ggcggcgctg ggccgggtcc tggcaagggc cgcaagaact cggcggccga gctggggagc    360

ggcagggccg gcgtcggccc caaggacagc cggctgtccc gcgacagcct gcagggtctg    420

attcaggccg ccgcgggcaa gggccgcaaa aactcccggg ccacggagga ggagccccac    480

cggggtgcaa ccaagagctc gggctgcagc acctacatca acaggctcat caaggtggac    540

actcaggaga agaacgggaa gagcaactac cccagcagca gtagctccag ctccagctcc    600

tcttcctccg cgtcctcttc cccttcctcc ctggggcccg agctggacaa gggcaagatt    660

attaagcagc aagagacggt catcatttta gaagactatg ctgaccctta tgatgccaaa    720

cggacaaagg gtcaaaggga tgcagagaga gtcggagaga acgacggtta catggaacca    780

tatgatgcac agcaaatgat aacagaaatt agacgacggg gttccaaaga tcccctggtg    840

aaggctctcc agctgcttga cagtccctgt gaacccgcag acggtggcct gaaatcagag    900

accttggcca aaagacggag ttccaaggac ctcctgggga agccgccaca gctatacgac    960

actccctacg agcctgcaga aggggggccc agggcagagg ggaaggcgcg gcccccagac   1020

agccggctgc ccgagaacga cgagaggccc gcggcagagt acgagcagcc atgggagtgg   1080

aagaaggagc agatcgtgcg ggctctgtca gtccagtttg aaggagctga gcgaccttcc   1140

ttcagggagg agacagtgag gcagcaccac cggcagaaga gctggaccca gaagatcctg   1200

aagccagccc tctcggacca cagtgaggga gagaaagtgg acccgggcct gcccctggag   1260

aagcagccct ggtatcatgg tgccatcagc cgtgctgagg ctgagagtcg actacagccc   1320

tgcaaagaag ctggttacct ggttcgaaat agtgagtcag ggaacagcag gtactccatt   1380

gccctaaaga ctagtcaagg atgtgtccac atcatagtgg ctcagaccaa agacaacaaa   1440

tacacactga atcagacaag cgctgtgttt gacagcatcc ctgaagtggt acactattat   1500

tccaatgaaa agttgccttt caaaggggca gaacacatga ctttactcta cccagtgcac   1560

agcaagcttc actaagattc agccactgca agccctgggc ctctggcacc ttcaagggca   1620

tcatcagcgc acaaccagca tctcagagga caaggctgga ctagcaactg ctagaaaatg   1680

ggagtcttcc ttgaaaagtc agagagtgat ttgttttgtt ttgtttgaga cgaagtctcg   1740

ctgtgttgcc caggctggag tgcaatggcg caatcttggc tcactgcaac atctgactcc   1800

tgggttcaag cagttcttcc ccatcagcct cccaagtagg tgggactata ggttcgcacc   1860

accactccca gctaattttt ttttttgtat ttttagtaga gatggggttt cgccgtcttc   1920

gtcaggctgg tctcaaactc ctgacctcaa atgatccacc cacctcagtc tccccgagtg   1980

cctggattac aggcatgagc cactgcaccc ggccaagtct ttggtcttaa agtgattcca   2040

tgacactttg tttgtggcct gtcccttgtt tccttgctaa gtagttctac aataagaaat   2100

catgatttag ctgttgcctc cagctctggg gtagggtgtt ctttttatgg tgtgaccctc   2160

aggaaggtta agtcaggagt tcaggagcat cagagttctc tagaaatgtg cctacttgtt   2220

acctggaata cctggtctct aaacaaacca acaaaaaatc cacgtggctt ttccacatga   2280

tggtgcagac tggaagagga tgttatattg gactcgttat tggggaaatg aatgagcggg   2340

agaaaatgtg aatgacgggc aagaaggtgg tctttctccc tcagaagtcc taattcagct   2400

ctggagttca tggaaatccg caacttcaga gtgtggccta aggattattt tgttggtcag   2460

cctttccaag aaagtgtgtg ttctctcaat ctctgtggat tttctcattt tttagcaaat   2520

cagtgagata agcataaata ggaaggaaga taccccaggt ttaagaatca ccaatatcat   2580

taggcattgg catcattatt agaattctga attatagaat aaaaggtaca acaaaaattt   2640

catttctgaa ttttaaaatt ctggaaattt gcaaagctcc acaactgttt ttttactgaa   2700

ttaattacat agaacttcga tgtcttttgt ttcatcatca ttgggcattt tagttgctat   2760

ggaataattt ttaatttttg tctctaaaat tagatttgct ttgtagtaaa ttttttaaaa   2820

atgcaaccct aagatctgat tatatgaact gggtctctaa agcctacaaa gattctctcg   2880

ttctgtacca agcagactgc cttgtactat acagaagtgt ttgaaaagac ctagaggttt   2940

tctcttaaat accattactt aagattcata gtattaggat ctttatgatt tatcatgagc   3000

ttatatcacc agtttattta ctgtgaaaaa aaccatggga atggcatact gtgagaagag   3060

tactatggtg aatggctcca gaattaaaat tcagcagatg tgtctgtatt ctggggttgg   3120

tcatttgggt ctcaaaactg ccccatatgc aaatgtactg actgtcatca atgaaaagtt   3180

aacctttgta gcttataaat acacacaaaa tgttgatttg gttaattttt taggaaagta   3240

tacctttgta gttactagtt acatttgact gtaagattta gaggttagta aatttttgct   3300

tctttattca gataagatct cagccaaaag gttgtgtgat ctttgatttt aaaaatttaa   3360

gaggaacttt tcctcactgg aacacaatga ttttattaat aaagaatgta ggctgggtgc   3420

ggtggctcat gcacgtaatc ccaacaattt gggaggctga ggcaggcaga tcacgtgagg   3480

tcaggagttt gagaccagcc tggccaacat ggtgaaaccc tgtctgtagt aaaaatacaa   3540

aaattagctg ggcacggtgg cgggcacctg tagttccagc tgcttgggag gctgaggcac   3600

gagaatcact tgagcccagg aggtggaggt tgcagtgagc caagattatg tcactgcact   3660

ccatcctggg tgacaagagc gaaactccat ctcaaaaaaa aaaaaaaaaa aaagcctggc   3720

ctggtggtgg atgcctgtgg ttccagctat tcgggaggct gaggtaggtg gatcacctct   3780

gctcaggtca aggctgcagc gagccatgat cgcaccattg cactccagcc tgagtgacag   3840

agtgagaccc tgtctcaaca agcaagcaaa caaaaaacca aaaggaatgt ttttttcaga   3900

tactgataga atgttttcag tgtgtattgg ttcatttact atatctttag tgtaagattt   3960

taaaaggttt tttcagcatc cattcaacaa atatttatta tctttataca aattattcat   4020

tgtgttaaac ttatttttag tttaacattc tagaaatgaa acgtttttac ttaaccttat   4080

tctacaaagg gaatacagca gttattctaa ttttaataaa tgctaaaagc tttatacaat   4140

ttttctttgt gcactaaatg atttttggcc catacccagc aactgtgatg aatgtataat   4200

gaaataacat cttgaaaaca ggccagatac attaagtatt tattgagctt ctgtcatatg   4260

cccagtatta tgcttcttct atactgtttc tctgtgacaa gtcatactat attctttata   4320

gaattaaaag tagaggagag gcagagttta catattgtcc agttgcttta cagttgtaca   4380

ggaggttata agaagaaata tagtaaatta gtgggaagtc agaggtgggg gcgttagtga   4440

gctattttct tcttgaggtt gtgacacaag ctgacaaaag ccagggagtt cacagctgtg   4500

tggtggcaca aagttccata tgttctaaaa acaattaggc ccagcagggt gtccctaatg   4560

gcttccttgt taaacctcca tggccagctg atctgaagct ctgtgacatg ttctctgagc   4620

tctgaatgct ctggcttttt gtcattttgt cttgagacaa gtattttcct gtagtcctca   4680

ttccttcgag ttattccatc tcccaggata ttctctggtg agaagaatgt ctttcagtga   4740

atttgccttg aatttagcat ccatagagct gtgtcagtgt tcttcttgat cacaccttct   4800

ttaaaaaaaa tacttgcttg cgatgactgg acaagttcag ttggttagtt tcaggcctat   4860

aagaagagag agtaaaggac cttgctattt actttgatac catagttgta tctcaggatg   4920

gcctgcaaac cactggcctt gtgtgtattt aagctaggaa taaaataatg gagaagtgtt   4980

aatatgtata caaaaaggta aatattgata tatctactct ctgttggggg cagaagtgtc   5040

attttaagtt attcaaagca ctttcttaag cattttagaa agcctttatt ctttgctgtt   5100

ggaagtctcc gtactttgca gaattggtat ttgtgtacta gcctctgccg caggatgggg   5160

aggtgggcag gtagctgata ggggcagcca ggagtttttg aggcaggtgg tgggaaattg   5220

tcctaatttg ttaattggat tatgtaactc tgttactagt ctgttattgg ctgttgttac   5280

tggatgcatc ttgatattca gaagaataac tgtgaggcat tcttcagttg cgggttaagt   5340

ggggttagtt tctgttctgt cagatgccct ttttcagtca aaggttagcc ccttgtttct   5400

ccctccttcc agggtttagg gagtgcagtg atgtcgattt catttccctt ccccgcaccc   5460

cttgacactc agcaggattg cactgaaacc cttcacagat ctctcgttca ctagttgtct   5520

cctatttttc cataactagc actagtttgg ccttatgacc tggttagaat cactcttctg   5580

tattctcatt tccaattttt gtgccccact aacgtggact agagaaactt ggcctgctgt   5640

gcagtgggcc ttctgttcaa cttaccctcc accgctgacc ctgtgtgaag agagatggtg   5700

cgttactgcc atctaatggg aaaagagaaa actgcagttg ggaaaagcag ctgtgcattt   5760

aagggtaggg ctttctgaag gatttctgat acagtccaga aaagggaaaa tgatgacaca   5820

gcagttgcca tcttgaaaaa tgccctttcc tgcggaaagg gtgttttgaa gtctaataca   5880

actatcatca caaggtccct ggactaaggc tggatcgtgt aatttagaat ctcaaattgt   5940

attttaatta atatgctggc aacagaatca ttgaaacagg cgtctcattt tgtcaagttc   6000

ttagccgttc agtttgtcag gggctttaat attttagata tcaactaata catagtttca   6060

acttttaaaa atgtttgaag attgtatgta atataggtgt ctatctatag tgccttagta   6120

atttaaatca gaaatatttt ataaaacttc tggttgtttt gcagtagcca atataggctt   6180

catgccctcc tgaagatagt ttcctctgaa atgtaacttt aaataaacat tattccaaga   6240

aaa                                                                 6243


<210>  1428
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  1428

Met Gln Trp Ser Pro Thr Pro Gly Ala Ser Ala Cys Leu Gly Trp Ala 
1               5                   10                  15      


Ser Ser Leu Ala Cys Ser Thr Ala Pro Thr Leu Leu Gly Arg Ala Gly 
            20                  25                  30          


Arg Gly Pro Leu Met Ala Ala Lys Trp Phe Lys Glu Phe Pro Leu Asn 
        35                  40                  45              


Leu Lys Thr Val Ser Glu Arg Ala Lys Pro Gly Gly Gly Gly Gly Lys 
    50                  55                  60                  


Leu Arg Lys Asn Ser Glu Ala Gly Gly Ala Gly Pro Gly Pro Gly Lys 
65                  70                  75                  80  


Gly Arg Lys Asn Ser Ala Ala Glu Leu Gly Ser Gly Arg Ala Gly Val 
                85                  90                  95      


Gly Pro Lys Asp Ser Arg Leu Ser Arg Asp Ser Leu Gln Gly Leu Ile 
            100                 105                 110         


Gln Ala Ala Ala Gly Lys Gly Arg Lys Asn Ser Arg Ala Thr Glu Glu 
        115                 120                 125             


Glu Pro His Arg Gly Ala Thr Lys Ser Ser Gly Cys Ser Thr Tyr Ile 
    130                 135                 140                 


Asn Arg Leu Ile Lys Val Asp Thr Gln Glu Lys Asn Gly Lys Ser Asn 
145                 150                 155                 160 


Tyr Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser 
                165                 170                 175     


Ser Ser Pro Ser Ser Leu Gly Pro Glu Leu Asp Lys Gly Lys Ile Ile 
            180                 185                 190         


Lys Gln Gln Glu Thr Val Ile Ile Leu Glu Asp Tyr Ala Asp Pro Tyr 
        195                 200                 205             


Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp Ala Glu Arg Val Gly Glu 
    210                 215                 220                 


Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala Gln Gln Met Ile Thr Glu 
225                 230                 235                 240 


Ile Arg Arg Arg Gly Ser Lys Asp Pro Leu Val Lys Ala Leu Gln Leu 
                245                 250                 255     


Leu Asp Ser Pro Cys Glu Pro Ala Asp Gly Gly Leu Lys Ser Glu Thr 
            260                 265                 270         


Leu Ala Lys Arg Arg Ser Ser Lys Asp Leu Leu Gly Lys Pro Pro Gln 
        275                 280                 285             


Leu Tyr Asp Thr Pro Tyr Glu Pro Ala Glu Gly Gly Pro Arg Ala Glu 
    290                 295                 300                 


Gly Lys Ala Arg Pro Pro Asp Ser Arg Leu Pro Glu Asn Asp Glu Arg 
305                 310                 315                 320 


Pro Ala Ala Glu Tyr Glu Gln Pro Trp Glu Trp Lys Lys Glu Gln Ile 
                325                 330                 335     


Val Arg Ala Leu Ser Val Gln Phe Glu Gly Ala Glu Arg Pro Ser Phe 
            340                 345                 350         


Arg Glu Glu Thr Val Arg Gln His His Arg Gln Lys Ser Trp Thr Gln 
        355                 360                 365             


Lys Ile Leu Lys Pro Ala Leu Ser Asp His Ser Glu Gly Glu Lys Val 
    370                 375                 380                 


Asp Pro Gly Leu Pro Leu Glu Lys Gln Pro Trp Tyr His Gly Ala Ile 
385                 390                 395                 400 


Ser Arg Ala Glu Ala Glu Ser Arg Leu Gln Pro Cys Lys Glu Ala Gly 
                405                 410                 415     


Tyr Leu Val Arg Asn Ser Glu Ser Gly Asn Ser Arg Tyr Ser Ile Ala 
            420                 425                 430         


Leu Lys Thr Ser Gln Gly Cys Val His Ile Ile Val Ala Gln Thr Lys 
        435                 440                 445             


Asp Asn Lys Tyr Thr Leu Asn Gln Thr Ser Ala Val Phe Asp Ser Ile 
    450                 455                 460                 


Pro Glu Val Val His Tyr Tyr Ser Asn Glu Lys Leu Pro Phe Lys Gly 
465                 470                 475                 480 


Ala Glu His Met Thr Leu Leu Tyr Pro Val His Ser Lys Leu His 
                485                 490                 495 


<210>  1429
<211>  2345
<212>  DNA
<213>  Homosapiens

<400>  1429
gtcttcaacg cctgcccggc ccgaggacac cgtggctctc ggaggcggcg ggcgccgggg     60

gcttccccct gctctttcct cctgcggtgg gagaggccag gcccacggaa gccccctgcg    120

gcccagccca cgctcccagg gaccagagag gaccgagcgg aggtggcggg agtatccccg    180

gcgcagcgac agacggtgga cggacggcga gcggcccatc aactccgcgc gcccctcccc    240

tccgcggctg gcgcctccca gccccgccac ctcctgccca gagctggggg cggcggggtg    300

agcgccatgg cagaggcggg tcgggctgcg agctctggag aaaggggcgg cggccgcacg    360

tgcggatcgg ccgcgcccca ctgagcagag agcccccttc tgccgccgac agcccgcgtc    420

tgcaccgagc cggtctcggc cgggcgctgc cttcacacgc gcccaggagt gtcacgtgcg    480

ccgctcaccc ccgggaagga agcccctcgc ccacccactc cgctctactc cactctttct    540

gcagacgtta tttttggcgg tagggcagag gttgcggccc gaggtccggg cgcagggaca    600

acggtcgcca gctcctgcgc tagttccgtt actcttcggt ggcacacggt cctgggcagc    660

gcgaggctct tcccgccgtg gccgccgggg attggctgcc ggcaagcccc gccccgtgcc    720

ccgggctcag agggggcgga gcgcggaggg agaaggcgcg aaggctgggc gtcgcgatcg    780

caggtgcacg cgcgtggccc gcgagacgag gagatcctgt tggaaagcaa ctgcagcatg    840

tcctggaaca ttagtcaccc ccaactctct gataaactgt ttgggaagaa tggagtgttg    900

gaggagcaga aatctccagg attcaagaaa agagagacag aggtgtatgt tggcaatctt    960

ccactggata tttctaagga ggaaattctg taccttctaa aggacttcaa ccctcttgat   1020

gtccacaaaa tccagaatgg ctgcaaatgc tttgcatttg tagatctggg ctccatgcag   1080

aaagtgacac ttgcaatcca ggagctgaat ggtaaactct tccacaagcg aaaactgttc   1140

gtgaatacaa gcaaaaggcc ccccaagagg acccctgata tgatccagca gcctcgggcc   1200

ccgctggtgt tggagaaggc ttctggtgaa ggatttggca aaaccgccgc tattatacag   1260

ctcgctccta aagctcctgt tgacctatgt gagacagaga aactgagggc agccttcttt   1320

gcagtcccgt tggaaatgag agggtccttc ctggtgctgc tcctgaggga atgcttccga   1380

gacctgagct ggctggcact catccatagc gtccgtgggg aggcggggct gctggtgacg   1440

agtatcgtcc cgaagacccc gtttttctgg gccatgcaca tcactgaggc tctgcaccag   1500

aacatgcagg ctctgtttag caccctggct caggcggagg agcagcagcc ctacctggag   1560

ggctccaccg ttatgcgcgg gactcgctgt ctggcagagt accacctggg ggattatgga   1620

cacgcctgga acaggtgttg ggtgctggac agggtggaca cctgggctgt ggtcatgttc   1680

attgattttg gacagttggc caccatccct gtgcagtctc tgcgcagcct agacagcgac   1740

gacttctgga ccatcccacc cctgactcag ccattcatgc tggagaaaga cattttgagt   1800

tcgtatgagg ttgtccatcg aatcctcaaa gggaaaatca ctggtgcttt gaactcggcg   1860

ttgcacatcc taaagtttga agagtctaaa taacggggct tccctcagca tgttccctct   1920

cctgtttgcc acggatccag aggccacctg ccctgtcttc tcgtacccct ttcactcttg   1980

aggcctggga ggtgaaaaag gccagactgt gcccaggatt gattcaattt tgcttttact   2040

cccagcttcc ctctcaaaag agagtgaagt ctcatttgtc atgtgtcttc agttccccaa   2100

cttggcatga acatttgaac caaacatagg aaactaccat taggttggaa gcctgaggca   2160

gctgggatgg tctttcttgt gtctcttctt tgcaccccag agcatgatat aagtggtcct   2220

aacagattct ggataatgga gaagccctct gctggttttc ctggcattcc atgtagaata   2280

ggtagagaat atttaaccaa tgagcaaata aatgttggca tgtttcatga aaaaaaaaaa   2340

aaaaa                                                               2345


<210>  1430
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  1430

Met Ile Gln Gln Pro Arg Ala Pro Leu Val Leu Glu Lys Ala Ser Gly 
1               5                   10                  15      


Glu Gly Phe Gly Lys Thr Ala Ala Ile Ile Gln Leu Ala Pro Lys Ala 
            20                  25                  30          


Pro Val Asp Leu Cys Glu Thr Glu Lys Leu Arg Ala Ala Phe Phe Ala 
        35                  40                  45              


Val Pro Leu Glu Met Arg Gly Ser Phe Leu Val Leu Leu Leu Arg Glu 
    50                  55                  60                  


Cys Phe Arg Asp Leu Ser Trp Leu Ala Leu Ile His Ser Val Arg Gly 
65                  70                  75                  80  


Glu Ala Gly Leu Leu Val Thr Ser Ile Val Pro Lys Thr Pro Phe Phe 
                85                  90                  95      


Trp Ala Met His Ile Thr Glu Ala Leu His Gln Asn Met Gln Ala Leu 
            100                 105                 110         


Phe Ser Thr Leu Ala Gln Ala Glu Glu Gln Gln Pro Tyr Leu Glu Gly 
        115                 120                 125             


Ser Thr Val Met Arg Gly Thr Arg Cys Leu Ala Glu Tyr His Leu Gly 
    130                 135                 140                 


Asp Tyr Gly His Ala Trp Asn Arg Cys Trp Val Leu Asp Arg Val Asp 
145                 150                 155                 160 


Thr Trp Ala Val Val Met Phe Ile Asp Phe Gly Gln Leu Ala Thr Ile 
                165                 170                 175     


Pro Val Gln Ser Leu Arg Ser Leu Asp Ser Asp Asp Phe Trp Thr Ile 
            180                 185                 190         


Pro Pro Leu Thr Gln Pro Phe Met Leu Glu Lys Asp Ile Leu Ser Ser 
        195                 200                 205             


Tyr Glu Val Val His Arg Ile Leu Lys Gly Lys Ile Thr Gly Ala Leu 
    210                 215                 220                 


Asn Ser Ala Leu His Ile Leu Lys Phe Glu Glu Ser Lys 
225                 230                 235         


<210>  1431
<211>  3256
<212>  DNA
<213>  Homosapiens

<400>  1431
cggcggcggc ggcggcggcg gcggcggcgg agcccggagc gcaggccgga ggctcccggc     60

ccgccggccc cggagcggag cggagcggag gatgcagcag ccgcagccgc aggggcagca    120

gcagccgggg ccggggcagc agctgggggg ccagggggcg gcgccggggg ccgggggcgg    180

cccagggggg ggcccggggc cggggccctg cctgaggcga gagctgaagc tgctcgagtc    240

catcttccac cgcggccacg agcgcttccg cattgccagc gcctgcctgg acgagctgag    300

ctgcgagttc ctgctggctg gggccggagg ggccggggcg ggggccgcgc ccggaccgca    360

tctcccccca cgggggtcgg tgcctgggga tcctgtccgc atccactgca acatcacgga    420

gtcataccct gctgtgcccc ccatctggtc ggtggagtct gatgacccta acttggctgc    480

tgtcttggag aggctggtgg acataaagaa agggaatact ctgctattgc agcatctgaa    540

gaggatcatc tccgacctgt gtaaactcta taacctccct cagcatccag atgtggagat    600

gctggatcaa cccttgccag cagagcagtg cacacaggaa gacgtgtctt cagaagatga    660

agatgaggag atgcctgagg acacagaaga cttagatcac tatgaaatga aagaggaaga    720

gccagctgag ggcaagaaat ctgaagatga tggcattgga aaagaaaact tggccatcct    780

agagaaaatt aaaaagaacc agaggcaaga ttacttaaat ggtgcagtgt ctggctcggt    840

gcaggccact gaccggctga tgaaggagct cagggatata taccgatcac agagtttcaa    900

aggcggaaac tatgcagtcg aactcgtgaa tgacagtctg tatgattgga atgtcaaact    960

cctcaaagtt gaccaggaca gcgctttgca caacgatctc cagatcctca aagagaaaga   1020

aggagccgac ttcattctac ttaacttttc ctttaaagat aactttccct ttgacccacc   1080

atttgtcagg gttgtgtctc cagtcctctc tggagggtat gttctgggcg gaggggccat   1140

ctgcatggaa cttctcacca aacagggctg gagcagtgcc tactccatag agtcagtgat   1200

catgcagatc agtgccacac tggtgaaggg gaaagcacga gtgcagtttg gagccaacaa   1260

atctcaatac agtctgacaa gagcacagca gtcctacaag tccttggtgc agatccacga   1320

aaaaaacggc tggtacacac ccccaaaaga agacggctaa ccctggagta tcacccttcc   1380

tccctcccca ggcaccactg gaccaattac ctttgaatgc tgtatttgga tctcacgctg   1440

cctctgtggt tccctccctc atttttcctg gacgtgatag ctctgcctat tgcaggacaa   1500

tgatggctat tctaaacgct aaggaaaaaa aacaaacaca gaactgtttc aagtactcaa   1560

gactgactta cagaccaacc aaccaccttg ctggaaccct tgctagcagg cattcttata   1620

aaagaaactt tcgagcctcc ttatattgct ggaaactcag ctgtgctcca gactagagcc   1680

tccttaccta tgctatggat ttttaattta ttttctctta tttcatgtac actgcttttt   1740

ttggttacag tgtatgatgg atgtgtatga aaaaaatgta tctttgggaa aacaattaca   1800

gtttgttaat ttgaagatgc tggtcttgac tcatctttat ttttattcgc acatcccacc   1860

ccatcccctg aactacttgg gaggtgggga ggggtacgag tccactgttg ctttggtaga   1920

gatgagaggc cgcattttgc tgctaaagca agagaaactt ggagctgaag cacacacctg   1980

gtctgcccct agatttctcc tcaaggcctc tggagcaacc agcacttgcc cccttggaat   2040

gcagagcctg gcctgccaaa ctacaatgtg gtaggctgaa acgatggtgt taattcttag   2100

gactactttt ctagtcacag atgttttcaa atttctaaga aaaagaaaat gaggctcaag   2160

aggctgcttc gtagaattcc ttttgaatga attgagtggg gatggggaca cagtctccaa   2220

gtgtgtatgt ggtcttttct gatctcagct gtgtggctgc aactcttcgc tgttcattgg   2280

ttcctctcct ggaaagtggc ttctaaccag cactggatgg tgatcattgg taagctttgc   2340

tcacctccct ctctcttgct tcatttggct ttatcaaaaa gaacagacct agctctgaat   2400

ttgtttggct tgggaaatta tggattcttt caagccactc ccacaaggtg ggtcctacta   2460

gaaagggtta gcattttaag gggggttgtt ctatacacct gtgtccttac cccaggctca   2520

ggaactgcca gggagggaag atgaggtggg gagtctgtac tgagatggaa ctgtcagtgc   2580

tgtgttgtat gtacttgctg ttgtaaaagt ttgggcatga ctttgcatct agcgggtgct   2640

gcctgcatct ctttgtctgt aagcttgctc tgggactcag cctcttagga cctacgatgc   2700

cagcagctct cattaacagt gaaatgacag aggccaaaga tggccaagtg aagacccaag   2760

tctcagaaaa cccagacttg ggacaactgc ctgggaacta ggatgctaga gcagttctgt   2820

aatgctttga gacacagcaa ttttcacatt ggccattctt tcccctcccc tacccctttt   2880

cttttgaggg acttttaatg tttgctgctt taggtggatg gagagtccac cagtcccact   2940

caatgctgct ctaactctac ccacacccac ctaattaggg gtgctaataa aacatgctga   3000

ggttgagata aagacgggac ataaggggaa aattcattcc atagagctga aatctggttt   3060

tcaaggcctc tgtggctttc ttctgaactt accaccagcc ctggctggaa tgtagattgt   3120

gtttttagta atgtgtactg tgagctgtct tctgtataat gtattttgta atgtattttt   3180

ctcatctacc aaaggatgaa acaaataaaa ttatttaaat agtaaagaaa aaaaaaaaaa   3240

aaaaaaaaaa aaaaaa                                                   3256


<210>  1432
<211>  422
<212>  PRT
<213>  Homosapiens

<400>  1432

Met Gln Gln Pro Gln Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln 
1               5                   10                  15      


Gln Leu Gly Gly Gln Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Pro Gly Pro Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu 
        35                  40                  45              


Glu Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala 
    50                  55                  60                  


Cys Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser 
                85                  90                  95      


Val Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr 
            100                 105                 110         


Pro Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu 
        115                 120                 125             


Ala Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu 
    130                 135                 140                 


Leu Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr 
145                 150                 155                 160 


Asn Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro 
                165                 170                 175     


Ala Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu 
            180                 185                 190         


Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu 
        195                 200                 205             


Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys 
    210                 215                 220                 


Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp 
225                 230                 235                 240 


Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu 
                245                 250                 255     


Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly 
            260                 265                 270         


Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val 
        275                 280                 285             


Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln 
    290                 295                 300                 


Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser 
305                 310                 315                 320 


Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser 
                325                 330                 335     


Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met 
            340                 345                 350         


Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser 
        355                 360                 365             


Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val 
    370                 375                 380                 


Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln 
385                 390                 395                 400 


Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr 
                405                 410                 415     


Pro Pro Lys Glu Asp Gly 
            420         


<210>  1433
<211>  2448
<212>  DNA
<213>  Homosapiens

<400>  1433
ctcctccccc tcaccgtccc aattgtattc cctggaagag cagccggaaa agcctccgcc     60

tgctcatacc aggataggca agaagctggt ttctcctcgc agccggctcc ctgaggccca    120

ggaaccaccg cggcggccgg caccacctgg acccagctcc aggcgggcgc ggcttcagca    180

ccacggacag cgccccaccc gcggccctcc ccccggcggc gcgctccagc cggtgtaggc    240

gaggcagcga gctatgcccg cggcatggcc cggcgctgcg gccccgtggc gctgctcctt    300

ggcttcggcc tcctccggct gtgctcaggg gtgtggggta cggatacaga ggagcggctg    360

gtggagcatc tcctggatcc ttcccgctac aacaagctta tccgcccagc caccaatggc    420

tctgagctgg tgacagtaca gcttatggtg tcactggccc agctcatcag tgtgcatgag    480

cgggagcaga tcatgaccac caatgtctgg ctgacccagg agtgggaaga ttatcgcctc    540

acctggaagc ctgaagagtt tgacaacatg aagaaagttc ggctcccttc caaacacatc    600

tggctcccag atgtggtcct gtacaacaat gctgacggca tgtacgaggt gtccttctat    660

tccaatgccg tggtctccta tgatggcagc atcttctggc tgccgcctgc catctacaag    720

agcgcatgca agattgaagt aaagcacttc ccatttgacc agcagaactg caccatgaag    780

ttccgttcgt ggacctacga ccgcacagag atcgacttgg tgctgaagag tgaggtggcc    840

agcctggacg acttcacacc tagtggtgag tgggacatcg tggcgctgcc gggccggcgc    900

aacgagaacc ccgacgactc tacgtacgtg gacatcacgt atgacttcat cattcgccgc    960

aagccgctct tctacaccat caacctcatc atcccctgtg tgctcatcac ctcgctagcc   1020

atccttgtct tctacctgcc atccgactgt ggcgagaaga tgacgttgtg catctcagtg   1080

ctgctggcgc tcacggtctt cctgctgctc atctccaaga tcgtgcctcc cacctccctc   1140

gacgtgccgc tcgtcggcaa gtacctcatg ttcaccatgg tgcttgtcac cttctccatc   1200

gtcaccagcg tgtgcgtgct caacgtgcac caccgctcgc ccaccacgca caccatggcg   1260

ccctgggtga aggtcgtctt cctggagaag ctgcccgcgc tgctcttcat gcagcagcca   1320

cgccatcatt gcgcccgtca gcgcctgcgc ctgcggcgac gccagcgtga gcgcgagggc   1380

gctggagccc tcttcttccg cgaagcccca ggggccgact cctgcacgtg cttcgtcaac   1440

cgcgcgtcgg tgcaggggtt ggccggggcc ttcggggctg agcctgcacc agtggcgggc   1500

cccgggcgct caggggagcc gtgtggctgt ggcctccggg aggcggtgga cggcgtgcgc   1560

ttcatcgcag accacatgcg gagcgaggac gatgaccaga gcgtgagtga ggactggaag   1620

tacgtcgcca tggtgatcga ccgcctcttc ctctggatct ttgtctttgt ctgtgtcttt   1680

ggcaccatcg gcatgttcct gcagcctctc ttccagaact acaccaccac caccttcctc   1740

cactcagacc actcagcccc cagctccaag tgaggccctt cctcatctcc atgctctttc   1800

accctgccac cctctgctgc acagtagtgt tgggtggagg atggacgagt gagctaccag   1860

gaagaggggc gctgccccca cagatccatc cttttgcttc atctggagtc cctcctcccc   1920

cacgcctcca tccacacaca gcagctccaa cctggaggct ggaccaactg ctttgttttg   1980

gctgctctcc atctcttgta ccagcccagg caatagtgtt gaggagggga gcaaggctgc   2040

taagtggaag acagagatgg cagagccatc caccctgagg agtgacgggc aaggggccag   2100

gaaggggaca ggattgtctg ctgcctccaa gtcatgggag aagaggggta taggacaagg   2160

ggtggaaggg caggagctca caccgcaccg ggctggcctg acacaatggt agctctgaag   2220

ggaggggaag agagaggcct gggtgtgacc tgacacctgc cgctgcttga gtggacagca   2280

gctggactgg gtgggcccca cagtggtcag cgattcctgc caagtagggt ttagccgggc   2340

cccatggtca cagacccctg ggggaggctt ccagctcagt cccacagccc cttgcttcta   2400

agggatccag agacctgctc cagatcctct ttccccactg aagaattc                2448


<210>  1434
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  1434

Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Thr Asp Thr Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn 
65                  70                  75                  80  


Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile 
    210                 215                 220                 


Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr 
    290                 295                 300                 


Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         


<210>  1435
<211>  6640
<212>  DNA
<213>  Homosapiens

<400>  1435
gaggaaacga aagcgaaatt gaaccggagc catcttgggc ccggcgcgca gacccgcgga     60

gtttcccgtg ccgacgcccc ggggccactt ccagtgcgga gtagcggagg cgtgggggcc    120

tcgaggggct ggcgcggccc agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg    180

ggcaatgcct cgcgggcgca atgaatccgc ggcaggggta ttccctcagc ggatactaca    240

cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct gggccaggat    300

cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag ctcccagaag    360

caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga ctccggccaa    420

ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc aggggtgtcc    480

ccaggggcgt gcatctcgga agtcaggggc tccagagagg gttccagcat ccttcaccac    540

gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc caggaactga    600

gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt ggggaaggga    660

aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa gaaatcaatc    720

gagttttata ctccctggca aagaagggca agctacagaa agaggcagga acaccccctt    780

tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg gtaagaccag    840

acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa gacagaaact    900

ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct caggcttgga    960

accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca aactcagacc   1020

caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct cttgagtttt   1080

tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg tctgactcct   1140

ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata aatgctgtgc   1200

taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct cccatatggc   1260

atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac agtgttcctg   1320

aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc acctgtaata   1380

tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag aatgggcagg   1440

aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca agactgaaac   1500

cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa aatggccagt   1560

gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca ggtgagtttc   1620

gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt tcaccctaca   1680

agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt   1740

tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc catgaacctc   1800

gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa gctggaagca   1860

agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta gaggaagcca   1920

aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag aaagaatcag   1980

agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt tctgggaaga   2040

gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc gaattccgtc   2100

tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt gcagtgggag   2160

cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag atggccgcag   2220

aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct gataaccagc   2280

ctgaaggtat gatctcagag tcacttgata acttggaatc catgatgccc aacaaggtca   2340

ggaagattgg cgagctcgtg agatacctga acaccaaccc tgtgggtggc cttttggagt   2400

acgcccgctc ccatggcttt gctgctgaat tcaagttggt cgaccagtcc ggacctcctc   2460

acgagcccaa gttcgtttac caagcaaaag ttgggggtcg ctggttccca gccgtctgcg   2520

cacacagcaa gaagcaaggc aagcaggaag cagcagatgc ggctctccgt gtcttgattg   2580

gggagaacga gaaggcagaa cgcatgggtt tcacagaggt aaccccagtg acaggggcca   2640

gtctcagaag aactatgctc ctcctctcaa ggtccccaga agcacagcca aagacactcc   2700

ctctcactgg cagcaccttc catgaccaga tagccatgct gagccaccgg tgcttcaaca   2760

ctctgactaa cagcttccag ccctccttgc tcggccgcaa gattctggcc gccatcatta   2820

tgaaaaaaga ctctgaggac atgggtgtcg tcgtcagctt gggaacaggg aatcgctgtg   2880

tgaaaggaga ttctctcagc ctaaaaggag aaactgtcaa tgactgccat gcagaaataa   2940

tctcccggag aggcttcatc aggtttctct acagtgagtt aatgaaatac aactcccaga   3000

ctgcgaagga tagtatattt gaacctgcta agggaggaga aaagctccaa ataaaaaaga   3060

ctgtgtcatt ccatctgtat atcagcactg ctccgtgtgg agatggcgcc ctctttgaca   3120

agtcctgcag cgaccgtgct atggaaagca cagaatcccg ccactaccct gtcttcgaga   3180

atcccaaaca aggaaagctc cgcaccaagg tggagaacgg agaaggcaca atccctgtgg   3240

aatccagtga cattgtgcct acgtgggatg gcattcggct cggggagaga ctccgtacca   3300

tgtcctgtag tgacaaaatc ctacgctgga acgtgctggg cctgcaaggg gcactgttga   3360

cccacttcct gcagcccatt tatctcaaat ctgtcacatt gggttacctt ttcagccaag   3420

ggcatctgac ccgtgctatt tgctgtcgtg tgacaagaga tgggagtgca tttgaggatg   3480

gactacgaca tccctttatt gtcaaccacc ccaaggttgg cagagtcagc atatatgatt   3540

ccaaaaggca atccgggaag actaaggaga caagcgtcaa ctggtgtctg gctgatggct   3600

atgacctgga gatcctggac ggtaccagag gcactgtgga tgggccacgg aatgaattgt   3660

cccgggtctc caaaaagaac atttttcttc tatttaagaa gctctgctcc ttccgttacc   3720

gcagggatct actgagactc tcctatggtg aggccaagaa agctgcccgt gactacgaga   3780

cggccaagaa ctacttcaaa aaaggcctga aggatatggg ctatgggaac tggattagca   3840

aaccccagga ggaaaagaac ttttatctct gcccagtata gtatgctcca gtgacagatg   3900

gattagggtg tgtcatacta gggtgtgaga gaggtaggtc gtagcattcc tcatcacatg   3960

gtcaggggat ttttttttct cctttttttt tctttttaag ccataattgg tgatactgaa   4020

aactttgggt tcccatttat cctgctttct ttgggattgc taggcaaggt ctggccaggc   4080

cccccttttt tcccccaagt gaagaggcag aaacctaaga agttatcttt tctttctacc   4140

caaagcatac atagtcactg agcacctgcg gtccatttcc tcttaaaagt tttgttttga   4200

tttgtttcca tttcctttcc ctttgtgttt gctacactga cctcttgcgg tcttgattag   4260

gtttcagtca actctggatc atgtcaggga ctgataattt catttgtgga ttacgcagac   4320

ccctctactt cccctctttc ccttctgaga ttctttcctt gtgatctgaa tgtctccttt   4380

tccccctcag agggcaaaga ggtgaacata aaggatttgg tgaaacattt gtaagggtag   4440

gagttgaaaa ctgcagttcc cagtgccacg gaagtgtgat tggagcctgc agataatgcc   4500

cagccatcct cccatcctgc actttagcca gctgcagggc gggcaaggca aggaaagctg   4560

cttccctgga agtgtatcac tttctccggc agctgggaag tctagaacca gccagactgg   4620

gttaagggag ctgctcaagc aatagcagag gtttcacccg gcaggatgac acagaccact   4680

tcccagggag cacgggcatg ccttggaata ttgccaagct tccagctgcc tcttctccta   4740

aagcattcct aggaatattt tccccgccaa tgctgggcgt acaccctagc caacgggaca   4800

aatcctagag ggtataaaat catctctgct cagataatca tgacttagca agaataaggg   4860

caaaaaatcc tgttggctta acgtcactgt tccacccggt gtaatatctc tcatgacagt   4920

gacaccaagg gaagttgact aagtcacatg taaattagga gtgttttaaa gaatgccata   4980

gatgttgatt cttaactgct acagataacc tgtaattgag cagatttaaa attcaggcat   5040

acttttccat ttatccaagt gctttcattt ttccagatgg cttcagaagt aggctcgtgg   5100

gcagggcgca gacctgatct ttatagggtt gacatagaaa gcagtagttg tgggtgaaag   5160

ggcaggttgt cttcaaactc tgtgaggtag aatcctttgt ctatacctcc atgaacattg   5220

actcgtgtgt tcagagcctt tggcctctct gtggagtctg gctctctggc tcctgtgcat   5280

tctttgaata gtcactcgta aaaactgtca gtgcttgaaa ctgtttcctt tactcatgtt   5340

gaagggactt tgttggcttt tagagtgttg gtcatgactc caagagcaga gcagggaaga   5400

gcccaagcat agacttggtg ccgtggtgat ggctgcagtc cagttttgtg atgctgcttt   5460

tacgtgtccc tcgataacag tcagctagac acactcagga ggactactga ggctctgcga   5520

ccttcaggag ctgagcctgc ctctctcctt tagatgacag accttcatct gggaacgtgc   5580

tgagccagca ccctcagatg atttccctcc aaactgctga ctaggtcatc ctctgtctgg   5640

tagagacatt cacatctttg cttttattct atgctctctg tacttttgac caaaaattga   5700

ccaaagtaag aaaatgcaag ttctaaaaat agactaagga tgcctttgca gaacaccaaa   5760

gcatcccaag gaactggtag ggaagtggcg cctgtctcct ggagtggaag aggcctgctc   5820

cctggctctg ggtctgctgg gggcacagta aatcagtctt ggcacccaca tccagggcag   5880

agaggtctgt ggttctcagc atcagaaggc agcgcagccc ctctcctctt caggctacag   5940

ggttgtcacc tgctgagtcc tcaggttgtt tggcctctct ggtccatctt gggcattagg   6000

ttctccagca gagctctggc cagctgcctc ttctttaact gggaacacag gctctcacaa   6060

gatcagaacc cccactcacc cccaagatct tatctagcaa gcctgtagta ttcagtttct   6120

gttgtaggaa gagagcgagg catccctgaa ttccacgcat ctgctggaaa cgagccgtgt   6180

cagatcgcac atccctgcgc ccccatgccc ctctgagtca cacaggacag aggaggcaga   6240

gcttctgccc actgttatct tcactttctt tgtccagtct tttgttttta ataagcagtg   6300

accctcccta ctcttctttt taatgatttt tgtagttgat ttgtctgaac tgtggctact   6360

gtgcattcct tgaataatca cttgtaaaaa ttgtcagtgc ttgaagctgt ttcctttact   6420

cacattgaag ggacttcgtt ggttttttgg agtcttggtt gtgactccaa gagcagagtg   6480

aggaagaccc ccaagcatag actcgggtac tgtgatgatg gctgcagtcc agttttatga   6540

ttctgctttt atgtgtccct tgataacagt gacttaacaa tatacattcc tcataaataa   6600

aaaaaaaaca agaatctgaa ttcttagaaa aaaaaaaaaa                         6640


<210>  1436
<211>  1226
<212>  PRT
<213>  Homosapiens

<400>  1436

Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Thr 
            820                 825                 830         


Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Thr Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Thr  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Thr Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Thr Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1130                 1135                 1140             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     


<210>  1437
<211>  6562
<212>  DNA
<213>  Homosapiens

<400>  1437
gaggaaacga aagcgaaatt gaaccggagc catcttgggc ccggcgcgca gacccgcgga     60

gtttcccgtg ccgacgcccc ggggccactt ccagtgcgga gtagcggagg cgtgggggcc    120

tcgaggggct ggcgcggccc agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg    180

ggcaatgcct cgcgggcgca atgaatccgc ggcaggggta ttccctcagc ggatactaca    240

cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct gggccaggat    300

cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag ctcccagaag    360

caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga ctccggccaa    420

ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc aggggtgtcc    480

ccaggggcgt gcatctcgga agtcaggggc tccagagagg gttccagcat ccttcaccac    540

gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc caggaactga    600

gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt ggggaaggga    660

aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa gaaatcaatc    720

gagttttata ctccctggca aagaagggca agctacagaa agaggcagga acaccccctt    780

tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg gtaagaccag    840

acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa gacagaaact    900

ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct caggcttgga    960

accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca aactcagacc   1020

caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct cttgagtttt   1080

tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg tctgactcct   1140

ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata aatgctgtgc   1200

taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct cccatatggc   1260

atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac agtgttcctg   1320

aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc acctgtaata   1380

tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag aatgggcagg   1440

aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca agactgaaac   1500

cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa aatggccagt   1560

gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca ggtgagtttc   1620

gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt tcaccctaca   1680

agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt   1740

tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc catgaacctc   1800

gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa gctggaagca   1860

agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta gaggaagcca   1920

aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag aaagaatcag   1980

agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt tctgggaaga   2040

gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc gaattccgtc   2100

tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt gcagtgggag   2160

cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag atggccgcag   2220

aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct gataaccagc   2280

ctgaaggtat gatctcagag tcacttgata acttggaatc catgatgccc aacaaggtca   2340

ggaagattgg cgagctcgtg agatacctga acaccaaccc tgtgggtggc cttttggagt   2400

acgcccgctc ccatggcttt gctgctgaat tcaagttggt cgaccagtcc ggacctcctc   2460

acgagcccaa gttcgtttac caagcaaaag ttgggggtcg ctggttccca gccgtctgcg   2520

cacacagcaa gaagcaaggc aagcaggaag cagcagatgc ggctctccgt gtcttgattg   2580

gggagaacga gaaggcagaa cgcatgggtt tcacagagct ccctctcact ggcagcacct   2640

tccatgacca gatagccatg ctgagccacc ggtgcttcaa cactctgact aacagcttcc   2700

agccctcctt gctcggccgc aagattctgg ccgccatcat tatgaaaaaa gactctgagg   2760

acatgggtgt cgtcgtcagc ttgggaacag ggaatcgctg tgtgaaagga gattctctca   2820

gcctaaaagg agaaactgtc aatgactgcc atgcagaaat aatctcccgg agaggcttca   2880

tcaggtttct ctacagtgag ttaatgaaat acaactccca gactgcgaag gatagtatat   2940

ttgaacctgc taagggagga gaaaagctcc aaataaaaaa gactgtgtca ttccatctgt   3000

atatcagcac tgctccgtgt ggagatggcg ccctctttga caagtcctgc agcgaccgtg   3060

ctatggaaag cacagaatcc cgccactacc ctgtcttcga gaatcccaaa caaggaaagc   3120

tccgcaccaa ggtggagaac ggagaaggca caatccctgt ggaatccagt gacattgtgc   3180

ctacgtggga tggcattcgg ctcggggaga gactccgtac catgtcctgt agtgacaaaa   3240

tcctacgctg gaacgtgctg ggcctgcaag gggcactgtt gacccacttc ctgcagccca   3300

tttatctcaa atctgtcaca ttgggttacc ttttcagcca agggcatctg acccgtgcta   3360

tttgctgtcg tgtgacaaga gatgggagtg catttgagga tggactacga catcccttta   3420

ttgtcaacca ccccaaggtt ggcagagtca gcatatatga ttccaaaagg caatccggga   3480

agactaagga gacaagcgtc aactggtgtc tggctgatgg ctatgacctg gagatcctgg   3540

acggtaccag aggcactgtg gatgggccac ggaatgaatt gtcccgggtc tccaaaaaga   3600

acatttttct tctatttaag aagctctgct ccttccgtta ccgcagggat ctactgagac   3660

tctcctatgg tgaggccaag aaagctgccc gtgactacga gacggccaag aactacttca   3720

aaaaaggcct gaaggatatg ggctatggga actggattag caaaccccag gaggaaaaga   3780

acttttatct ctgcccagta tagtatgctc cagtgacaga tggattaggg tgtgtcatac   3840

tagggtgtga gagaggtagg tcgtagcatt cctcatcaca tggtcagggg attttttttt   3900

ctcctttttt tttcttttta agccataatt ggtgatactg aaaactttgg gttcccattt   3960

atcctgcttt ctttgggatt gctaggcaag gtctggccag gccccccttt tttcccccaa   4020

gtgaagaggc agaaacctaa gaagttatct tttctttcta cccaaagcat acatagtcac   4080

tgagcacctg cggtccattt cctcttaaaa gttttgtttt gatttgtttc catttccttt   4140

ccctttgtgt ttgctacact gacctcttgc ggtcttgatt aggtttcagt caactctgga   4200

tcatgtcagg gactgataat ttcatttgtg gattacgcag acccctctac ttcccctctt   4260

tcccttctga gattctttcc ttgtgatctg aatgtctcct tttccccctc agagggcaaa   4320

gaggtgaaca taaaggattt ggtgaaacat ttgtaagggt aggagttgaa aactgcagtt   4380

cccagtgcca cggaagtgtg attggagcct gcagataatg cccagccatc ctcccatcct   4440

gcactttagc cagctgcagg gcgggcaagg caaggaaagc tgcttccctg gaagtgtatc   4500

actttctccg gcagctggga agtctagaac cagccagact gggttaaggg agctgctcaa   4560

gcaatagcag aggtttcacc cggcaggatg acacagacca cttcccaggg agcacgggca   4620

tgccttggaa tattgccaag cttccagctg cctcttctcc taaagcattc ctaggaatat   4680

tttccccgcc aatgctgggc gtacacccta gccaacggga caaatcctag agggtataaa   4740

atcatctctg ctcagataat catgacttag caagaataag ggcaaaaaat cctgttggct   4800

taacgtcact gttccacccg gtgtaatatc tctcatgaca gtgacaccaa gggaagttga   4860

ctaagtcaca tgtaaattag gagtgtttta aagaatgcca tagatgttga ttcttaactg   4920

ctacagataa cctgtaattg agcagattta aaattcaggc atacttttcc atttatccaa   4980

gtgctttcat ttttccagat ggcttcagaa gtaggctcgt gggcagggcg cagacctgat   5040

ctttataggg ttgacataga aagcagtagt tgtgggtgaa agggcaggtt gtcttcaaac   5100

tctgtgaggt agaatccttt gtctatacct ccatgaacat tgactcgtgt gttcagagcc   5160

tttggcctct ctgtggagtc tggctctctg gctcctgtgc attctttgaa tagtcactcg   5220

taaaaactgt cagtgcttga aactgtttcc tttactcatg ttgaagggac tttgttggct   5280

tttagagtgt tggtcatgac tccaagagca gagcagggaa gagcccaagc atagacttgg   5340

tgccgtggtg atggctgcag tccagttttg tgatgctgct tttacgtgtc cctcgataac   5400

agtcagctag acacactcag gaggactact gaggctctgc gaccttcagg agctgagcct   5460

gcctctctcc tttagatgac agaccttcat ctgggaacgt gctgagccag caccctcaga   5520

tgatttccct ccaaactgct gactaggtca tcctctgtct ggtagagaca ttcacatctt   5580

tgcttttatt ctatgctctc tgtacttttg accaaaaatt gaccaaagta agaaaatgca   5640

agttctaaaa atagactaag gatgcctttg cagaacacca aagcatccca aggaactggt   5700

agggaagtgg cgcctgtctc ctggagtgga agaggcctgc tccctggctc tgggtctgct   5760

gggggcacag taaatcagtc ttggcaccca catccagggc agagaggtct gtggttctca   5820

gcatcagaag gcagcgcagc ccctctcctc ttcaggctac agggttgtca cctgctgagt   5880

cctcaggttg tttggcctct ctggtccatc ttgggcatta ggttctccag cagagctctg   5940

gccagctgcc tcttctttaa ctgggaacac aggctctcac aagatcagaa cccccactca   6000

cccccaagat cttatctagc aagcctgtag tattcagttt ctgttgtagg aagagagcga   6060

ggcatccctg aattccacgc atctgctgga aacgagccgt gtcagatcgc acatccctgc   6120

gcccccatgc ccctctgagt cacacaggac agaggaggca gagcttctgc ccactgttat   6180

cttcactttc tttgtccagt cttttgtttt taataagcag tgaccctccc tactcttctt   6240

tttaatgatt tttgtagttg atttgtctga actgtggcta ctgtgcattc cttgaataat   6300

cacttgtaaa aattgtcagt gcttgaagct gtttccttta ctcacattga agggacttcg   6360

ttggtttttt ggagtcttgg ttgtgactcc aagagcagag tgaggaagac ccccaagcat   6420

agactcgggt actgtgatga tggctgcagt ccagttttat gattctgctt ttatgtgtcc   6480

cttgataaca gtgacttaac aatatacatt cctcataaat aaaaaaaaaa caagaatctg   6540

aattcttaga aaaaaaaaaa aa                                            6562


<210>  1438
<211>  1200
<212>  PRT
<213>  Homosapiens

<400>  1438

Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Leu Pro Leu Thr Gly Ser Thr Phe His Asp 
                805                 810                 815     


Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser 
            820                 825                 830         


Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met 
        835                 840                 845             


Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly 
    850                 855                 860                 


Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val 
865                 870                 875                 880 


Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe 
                885                 890                 895     


Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser 
            900                 905                 910         


Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr 
        915                 920                 925             


Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala 
    930                 935                 940                 


Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser 
945                 950                 955                 960 


Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr 
                965                 970                 975     


Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile 
            980                 985                 990         


Val Pro Thr Trp Asp Gly Ile Arg  Leu Gly Glu Arg Leu  Arg Thr Met 
        995                 1000                 1005             


Ser Cys  Ser Asp Lys Ile Leu  Arg Trp Asn Val Leu  Gly Leu Gln 
    1010                 1015                 1020             


Gly Ala  Leu Leu Thr His Phe  Leu Gln Pro Ile Tyr  Leu Lys Ser 
    1025                 1030                 1035             


Val Thr  Leu Gly Tyr Leu Phe  Ser Gln Gly His Leu  Thr Arg Ala 
    1040                 1045                 1050             


Ile Cys  Cys Arg Val Thr Arg  Asp Gly Ser Ala Phe  Glu Asp Gly 
    1055                 1060                 1065             


Leu Arg  His Pro Phe Ile Val  Asn His Pro Lys Val  Gly Arg Val 
    1070                 1075                 1080             


Ser Ile  Tyr Asp Ser Lys Arg  Gln Ser Gly Lys Thr  Lys Glu Thr 
    1085                 1090                 1095             


Ser Val  Asn Trp Cys Leu Ala  Asp Gly Tyr Asp Leu  Glu Ile Leu 
    1100                 1105                 1110             


Asp Gly  Thr Arg Gly Thr Val  Asp Gly Pro Arg Asn  Glu Leu Ser 
    1115                 1120                 1125             


Arg Val  Ser Lys Lys Asn Ile  Phe Leu Leu Phe Lys  Lys Leu Cys 
    1130                 1135                 1140             


Ser Phe  Arg Tyr Arg Arg Asp  Leu Leu Arg Leu Ser  Tyr Gly Glu 
    1145                 1150                 1155             


Ala Lys  Lys Ala Ala Arg Asp  Tyr Glu Thr Ala Lys  Asn Tyr Phe 
    1160                 1165                 1170             


Lys Lys  Gly Leu Lys Asp Met  Gly Tyr Gly Asn Trp  Ile Ser Lys 
    1175                 1180                 1185             


Pro Gln  Glu Glu Lys Asn Phe  Tyr Leu Cys Pro Val  
    1190                 1195                 1200 


<210>  1439
<211>  6532
<212>  DNA
<213>  Homosapiens

<400>  1439
gactgaaggt agagaaggct acgtggtggg ggagggtggg gggagggtcg cggccgcact     60

ggcagcctcc gggtgtccgg ccgtgtcccg aggaagtgca agacccgggg tattccctca    120

gcggatacta cacccatcca tttcaaggct atgagcacag acagctcagg taccagcagc    180

ctgggccagg atcttccccc agtagtttcc tgcttaagca aatagaattt ctcaaggggc    240

agctcccaga agcaccggtg attggaaagc agacaccgtc actgccacct tccctcccag    300

gactccggcc aaggtttcca gtactacttg cctccagtac cagaggcagg caagtggaca    360

tcaggggtgt ccccaggggc gtgcatctcg gaagtcaggg gctccagaga gggttccagc    420

atccttcacc acgtggcagg agtctgccac agagaggtgt tgattgcctt tcctcacatt    480

tccaggaact gagtatctac caagatcagg aacaaaggat cttaaagttc ctggaagagc    540

ttggggaagg gaaggccacc acagcacatg atctgtctgg gaaacttggg actccgaaga    600

aagaaatcaa tcgagtttta tactccctgg caaagaaggg caagctacag aaagaggcag    660

gaacaccccc tttgtggaaa atcgcggtct ccactcaggc ttggaaccag cacagcggag    720

tggtaagacc agacggtcat agccaaggag ccccaaactc agacccgagt ttggaaccgg    780

aagacagaaa ctccacatct gtctcagaag atcttcttga gccttttatt gcagtctcag    840

ctcaggcttg gaaccagcac agcggagtgg taagaccaga cagtcatagc caaggatccc    900

caaactcaga cccaggtttg gaacctgaag acagcaactc cacatctgcc ttggaagatc    960

ctcttgagtt tttagacatg gccgagatca aggagaaaat ctgcgactat ctcttcaatg   1020

tgtctgactc ctctgccctg aatttggcta aaaatattgg ccttaccaag gcccgagata   1080

taaatgctgt gctaattgac atggaaaggc agggggatgt ctatagacaa gggacaaccc   1140

ctcccatatg gcatttgaca gacaagaagc gagagaggat gcaaatcaag agaaatacga   1200

acagtgttcc tgaaaccgct ccagctgcaa tccctgagac caaaagaaac gcagagttcc   1260

tcacctgtaa tatacccaca tcaaatgcct caaataacat ggtaaccaca gaaaaagtgg   1320

agaatgggca ggaacctgtc ataaagttag aaaacaggca agaggccaga ccagaaccag   1380

caagactgaa accacctgtt cattacaatg gcccctcaaa agcagggtat gttgactttg   1440

aaaatggcca gtgggccaca gatgacatcc cagatgactt gaatagtatc cgcgcagcac   1500

caggtgagtt tcgagccatc atggagatgc cctccttcta cagtcatggc ttgccacggt   1560

gttcacccta caagaaactg acagagtgcc agctgaagaa ccccatcagc gggctgttag   1620

aatatgccca gttcgctagt caaacctgtg agttcaacat gatagagcag agtggaccac   1680

cccatgaacc tcgatttaaa ttccaggttg tcatcaatgg ccgagagttt cccccagctg   1740

aagctggaag caagaaagtg gccaagcagg atgcagctat gaaagccatg acaattctgc   1800

tagaggaagc caaagccaag gacagtggaa aatcagaaga atcatcccac tattccacag   1860

agaaagaatc agagaagact gcagagtccc agacccccac cccttcagcc acatccttct   1920

tttctgggaa gagccccgtc accacactgc ttgagtgtat gcacaaattg gggaactcct   1980

gcgaattccg tctcctgtcc aaagaaggcc ctgcccatga acccaagttc caatactgtg   2040

ttgcagtggg agcccaaact ttccccagtg tgagtgctcc cagcaagaaa gtggcaaagc   2100

agatggccgc agaggaagcc atgaaggccc tgcatgggga ggcgaccaac tccatggctt   2160

ctgataacca gcctgaaggt atgatctcag agtcacttga taacttggaa tccatgatgc   2220

ccaacaaggt caggaagatt ggcgagctcg tgagatacct gaacaccaac cctgtgggtg   2280

gccttttgga gtacgcccgc tcccatggct ttgctgctga attcaagttg gtcgaccagt   2340

ccggacctcc tcacgagccc aagttcgttt accaagcaaa agttgggggt cgctggttcc   2400

cagccgtctg cgcacacagc aagaagcaag gcaagcagga agcagcagat gcggctctcc   2460

gtgtcttgat tggggagaac gagaaggcag aacgcatggg tttcacagag gtaaccccag   2520

tgacaggggc cagtctcaga agaactatgc tcctcctctc aaggtcccca gaagcacagc   2580

caaagacact ccctctcact ggcagcacct tccatgacca gatagccatg ctgagccacc   2640

ggtgcttcaa cactctgact aacagcttcc agccctcctt gctcggccgc aagattctgg   2700

ccgccatcat tatgaaaaaa gactctgagg acatgggtgt cgtcgtcagc ttgggaacag   2760

ggaatcgctg tgtgaaagga gattctctca gcctaaaagg agaaactgtc aatgactgcc   2820

atgcagaaat aatctcccgg agaggcttca tcaggtttct ctacagtgag ttaatgaaat   2880

acaactccca gactgcgaag gatagtatat ttgaacctgc taagggagga gaaaagctcc   2940

aaataaaaaa gactgtgtca ttccatctgt atatcagcac tgctccgtgt ggagatggcg   3000

ccctctttga caagtcctgc agcgaccgtg ctatggaaag cacagaatcc cgccactacc   3060

ctgtcttcga gaatcccaaa caaggaaagc tccgcaccaa ggtggagaac ggagaaggca   3120

caatccctgt ggaatccagt gacattgtgc ctacgtggga tggcattcgg ctcggggaga   3180

gactccgtac catgtcctgt agtgacaaaa tcctacgctg gaacgtgctg ggcctgcaag   3240

gggcactgtt gacccacttc ctgcagccca tttatctcaa atctgtcaca ttgggttacc   3300

ttttcagcca agggcatctg acccgtgcta tttgctgtcg tgtgacaaga gatgggagtg   3360

catttgagga tggactacga catcccttta ttgtcaacca ccccaaggtt ggcagagtca   3420

gcatatatga ttccaaaagg caatccggga agactaagga gacaagcgtc aactggtgtc   3480

tggctgatgg ctatgacctg gagatcctgg acggtaccag aggcactgtg gatgggccac   3540

ggaatgaatt gtcccgggtc tccaaaaaga acatttttct tctatttaag aagctctgct   3600

ccttccgtta ccgcagggat ctactgagac tctcctatgg tgaggccaag aaagctgccc   3660

gtgactacga gacggccaag aactacttca aaaaaggcct gaaggatatg ggctatggga   3720

actggattag caaaccccag gaggaaaaga acttttatct ctgcccagta tagtatgctc   3780

cagtgacaga tggattaggg tgtgtcatac tagggtgtga gagaggtagg tcgtagcatt   3840

cctcatcaca tggtcagggg attttttttt ctcctttttt tttcttttta agccataatt   3900

ggtgatactg aaaactttgg gttcccattt atcctgcttt ctttgggatt gctaggcaag   3960

gtctggccag gccccccttt tttcccccaa gtgaagaggc agaaacctaa gaagttatct   4020

tttctttcta cccaaagcat acatagtcac tgagcacctg cggtccattt cctcttaaaa   4080

gttttgtttt gatttgtttc catttccttt ccctttgtgt ttgctacact gacctcttgc   4140

ggtcttgatt aggtttcagt caactctgga tcatgtcagg gactgataat ttcatttgtg   4200

gattacgcag acccctctac ttcccctctt tcccttctga gattctttcc ttgtgatctg   4260

aatgtctcct tttccccctc agagggcaaa gaggtgaaca taaaggattt ggtgaaacat   4320

ttgtaagggt aggagttgaa aactgcagtt cccagtgcca cggaagtgtg attggagcct   4380

gcagataatg cccagccatc ctcccatcct gcactttagc cagctgcagg gcgggcaagg   4440

caaggaaagc tgcttccctg gaagtgtatc actttctccg gcagctggga agtctagaac   4500

cagccagact gggttaaggg agctgctcaa gcaatagcag aggtttcacc cggcaggatg   4560

acacagacca cttcccaggg agcacgggca tgccttggaa tattgccaag cttccagctg   4620

cctcttctcc taaagcattc ctaggaatat tttccccgcc aatgctgggc gtacacccta   4680

gccaacggga caaatcctag agggtataaa atcatctctg ctcagataat catgacttag   4740

caagaataag ggcaaaaaat cctgttggct taacgtcact gttccacccg gtgtaatatc   4800

tctcatgaca gtgacaccaa gggaagttga ctaagtcaca tgtaaattag gagtgtttta   4860

aagaatgcca tagatgttga ttcttaactg ctacagataa cctgtaattg agcagattta   4920

aaattcaggc atacttttcc atttatccaa gtgctttcat ttttccagat ggcttcagaa   4980

gtaggctcgt gggcagggcg cagacctgat ctttataggg ttgacataga aagcagtagt   5040

tgtgggtgaa agggcaggtt gtcttcaaac tctgtgaggt agaatccttt gtctatacct   5100

ccatgaacat tgactcgtgt gttcagagcc tttggcctct ctgtggagtc tggctctctg   5160

gctcctgtgc attctttgaa tagtcactcg taaaaactgt cagtgcttga aactgtttcc   5220

tttactcatg ttgaagggac tttgttggct tttagagtgt tggtcatgac tccaagagca   5280

gagcagggaa gagcccaagc atagacttgg tgccgtggtg atggctgcag tccagttttg   5340

tgatgctgct tttacgtgtc cctcgataac agtcagctag acacactcag gaggactact   5400

gaggctctgc gaccttcagg agctgagcct gcctctctcc tttagatgac agaccttcat   5460

ctgggaacgt gctgagccag caccctcaga tgatttccct ccaaactgct gactaggtca   5520

tcctctgtct ggtagagaca ttcacatctt tgcttttatt ctatgctctc tgtacttttg   5580

accaaaaatt gaccaaagta agaaaatgca agttctaaaa atagactaag gatgcctttg   5640

cagaacacca aagcatccca aggaactggt agggaagtgg cgcctgtctc ctggagtgga   5700

agaggcctgc tccctggctc tgggtctgct gggggcacag taaatcagtc ttggcaccca   5760

catccagggc agagaggtct gtggttctca gcatcagaag gcagcgcagc ccctctcctc   5820

ttcaggctac agggttgtca cctgctgagt cctcaggttg tttggcctct ctggtccatc   5880

ttgggcatta ggttctccag cagagctctg gccagctgcc tcttctttaa ctgggaacac   5940

aggctctcac aagatcagaa cccccactca cccccaagat cttatctagc aagcctgtag   6000

tattcagttt ctgttgtagg aagagagcga ggcatccctg aattccacgc atctgctgga   6060

aacgagccgt gtcagatcgc acatccctgc gcccccatgc ccctctgagt cacacaggac   6120

agaggaggca gagcttctgc ccactgttat cttcactttc tttgtccagt cttttgtttt   6180

taataagcag tgaccctccc tactcttctt tttaatgatt tttgtagttg atttgtctga   6240

actgtggcta ctgtgcattc cttgaataat cacttgtaaa aattgtcagt gcttgaagct   6300

gtttccttta ctcacattga agggacttcg ttggtttttt ggagtcttgg ttgtgactcc   6360

aagagcagag tgaggaagac ccccaagcat agactcgggt actgtgatga tggctgcagt   6420

ccagttttat gattctgctt ttatgtgtcc cttgataaca gtgacttaac aatatacatt   6480

cctcataaat aaaaaaaaaa caagaatctg aattcttaga aaaaaaaaaa aa           6532


<210>  1440
<211>  931
<212>  PRT
<213>  Homosapiens

<400>  1440

Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Val 
            500                 505                 510         


Thr Pro Val Thr Gly Ala Ser Leu Arg Arg Thr Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu 
545                 550                 555                 560 


Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg 
        835                 840                 845             


Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     


<210>  1441
<211>  6505
<212>  DNA
<213>  Homosapiens

<400>  1441
gaggaaacga aagcgaaatt gaaccggagc catcttgggc ccggcgcgca gacccgcgga     60

gtttcccgtg ccgacgcccc ggggccactt ccagtgcgga gtagcggagg cgtgggggcc    120

tcgaggggct ggcgcggccc agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg    180

ggcaatgcct cgcgggcgca atgaatccgc ggcaggggta ttccctcagc ggatactaca    240

cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct gggccaggat    300

cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag ctcccagaag    360

caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga ctccggccaa    420

ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc aggggtgtcc    480

ccaggggcgt gcatctcgga agtcaggggc tccagagagg gttccagcat ccttcaccac    540

gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc caggaactga    600

gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt ggggaaggga    660

aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa gaaatcaatc    720

gagttttata ctccctggca aagaagggca agctacagaa agaggcagga acaccccctt    780

tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg gtaagaccag    840

acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa gacagaaact    900

ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct caggcttgga    960

accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca aactcagacc   1020

caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct cttgagtttt   1080

tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg tctgactcct   1140

ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata aatgctgtgc   1200

taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct cccatatggc   1260

atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac agtgttcctg   1320

aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc acctgtaata   1380

tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag aatgggcagg   1440

aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca agactgaaac   1500

cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa aatggccagt   1560

gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca ggtgagtttc   1620

gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt tcaccctaca   1680

agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt   1740

tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc catgaacctc   1800

gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa gctggaagca   1860

agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta gaggaagcca   1920

aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag aaagaatcag   1980

agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt tctgggaaga   2040

gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc gaattccgtc   2100

tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt gcagtgggag   2160

cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag atggccgcag   2220

aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct gataaccagg   2280

tcaggaagat tggcgagctc gtgagatacc tgaacaccaa ccctgtgggt ggccttttgg   2340

agtacgcccg ctcccatggc tttgctgctg aattcaagtt ggtcgaccag tccggacctc   2400

ctcacgagcc caagttcgtt taccaagcaa aagttggggg tcgctggttc ccagccgtct   2460

gcgcacacag caagaagcaa ggcaagcagg aagcagcaga tgcggctctc cgtgtcttga   2520

ttggggagaa cgagaaggca gaacgcatgg gtttcacaga gctccctctc actggcagca   2580

ccttccatga ccagatagcc atgctgagcc accggtgctt caacactctg actaacagct   2640

tccagccctc cttgctcggc cgcaagattc tggccgccat cattatgaaa aaagactctg   2700

aggacatggg tgtcgtcgtc agcttgggaa cagggaatcg ctgtgtgaaa ggagattctc   2760

tcagcctaaa aggagaaact gtcaatgact gccatgcaga aataatctcc cggagaggct   2820

tcatcaggtt tctctacagt gagttaatga aatacaactc ccagactgcg aaggatagta   2880

tatttgaacc tgctaaggga ggagaaaagc tccaaataaa aaagactgtg tcattccatc   2940

tgtatatcag cactgctccg tgtggagatg gcgccctctt tgacaagtcc tgcagcgacc   3000

gtgctatgga aagcacagaa tcccgccact accctgtctt cgagaatccc aaacaaggaa   3060

agctccgcac caaggtggag aacggagaag gcacaatccc tgtggaatcc agtgacattg   3120

tgcctacgtg ggatggcatt cggctcgggg agagactccg taccatgtcc tgtagtgaca   3180

aaatcctacg ctggaacgtg ctgggcctgc aaggggcact gttgacccac ttcctgcagc   3240

ccatttatct caaatctgtc acattgggtt accttttcag ccaagggcat ctgacccgtg   3300

ctatttgctg tcgtgtgaca agagatggga gtgcatttga ggatggacta cgacatccct   3360

ttattgtcaa ccaccccaag gttggcagag tcagcatata tgattccaaa aggcaatccg   3420

ggaagactaa ggagacaagc gtcaactggt gtctggctga tggctatgac ctggagatcc   3480

tggacggtac cagaggcact gtggatgggc cacggaatga attgtcccgg gtctccaaaa   3540

agaacatttt tcttctattt aagaagctct gctccttccg ttaccgcagg gatctactga   3600

gactctccta tggtgaggcc aagaaagctg cccgtgacta cgagacggcc aagaactact   3660

tcaaaaaagg cctgaaggat atgggctatg ggaactggat tagcaaaccc caggaggaaa   3720

agaactttta tctctgccca gtatagtatg ctccagtgac agatggatta gggtgtgtca   3780

tactagggtg tgagagaggt aggtcgtagc attcctcatc acatggtcag gggatttttt   3840

tttctccttt ttttttcttt ttaagccata attggtgata ctgaaaactt tgggttccca   3900

tttatcctgc tttctttggg attgctaggc aaggtctggc caggcccccc ttttttcccc   3960

caagtgaaga ggcagaaacc taagaagtta tcttttcttt ctacccaaag catacatagt   4020

cactgagcac ctgcggtcca tttcctctta aaagttttgt tttgatttgt ttccatttcc   4080

tttccctttg tgtttgctac actgacctct tgcggtcttg attaggtttc agtcaactct   4140

ggatcatgtc agggactgat aatttcattt gtggattacg cagacccctc tacttcccct   4200

ctttcccttc tgagattctt tccttgtgat ctgaatgtct ccttttcccc ctcagagggc   4260

aaagaggtga acataaagga tttggtgaaa catttgtaag ggtaggagtt gaaaactgca   4320

gttcccagtg ccacggaagt gtgattggag cctgcagata atgcccagcc atcctcccat   4380

cctgcacttt agccagctgc agggcgggca aggcaaggaa agctgcttcc ctggaagtgt   4440

atcactttct ccggcagctg ggaagtctag aaccagccag actgggttaa gggagctgct   4500

caagcaatag cagaggtttc acccggcagg atgacacaga ccacttccca gggagcacgg   4560

gcatgccttg gaatattgcc aagcttccag ctgcctcttc tcctaaagca ttcctaggaa   4620

tattttcccc gccaatgctg ggcgtacacc ctagccaacg ggacaaatcc tagagggtat   4680

aaaatcatct ctgctcagat aatcatgact tagcaagaat aagggcaaaa aatcctgttg   4740

gcttaacgtc actgttccac ccggtgtaat atctctcatg acagtgacac caagggaagt   4800

tgactaagtc acatgtaaat taggagtgtt ttaaagaatg ccatagatgt tgattcttaa   4860

ctgctacaga taacctgtaa ttgagcagat ttaaaattca ggcatacttt tccatttatc   4920

caagtgcttt catttttcca gatggcttca gaagtaggct cgtgggcagg gcgcagacct   4980

gatctttata gggttgacat agaaagcagt agttgtgggt gaaagggcag gttgtcttca   5040

aactctgtga ggtagaatcc tttgtctata cctccatgaa cattgactcg tgtgttcaga   5100

gcctttggcc tctctgtgga gtctggctct ctggctcctg tgcattcttt gaatagtcac   5160

tcgtaaaaac tgtcagtgct tgaaactgtt tcctttactc atgttgaagg gactttgttg   5220

gcttttagag tgttggtcat gactccaaga gcagagcagg gaagagccca agcatagact   5280

tggtgccgtg gtgatggctg cagtccagtt ttgtgatgct gcttttacgt gtccctcgat   5340

aacagtcagc tagacacact caggaggact actgaggctc tgcgaccttc aggagctgag   5400

cctgcctctc tcctttagat gacagacctt catctgggaa cgtgctgagc cagcaccctc   5460

agatgatttc cctccaaact gctgactagg tcatcctctg tctggtagag acattcacat   5520

ctttgctttt attctatgct ctctgtactt ttgaccaaaa attgaccaaa gtaagaaaat   5580

gcaagttcta aaaatagact aaggatgcct ttgcagaaca ccaaagcatc ccaaggaact   5640

ggtagggaag tggcgcctgt ctcctggagt ggaagaggcc tgctccctgg ctctgggtct   5700

gctgggggca cagtaaatca gtcttggcac ccacatccag ggcagagagg tctgtggttc   5760

tcagcatcag aaggcagcgc agcccctctc ctcttcaggc tacagggttg tcacctgctg   5820

agtcctcagg ttgtttggcc tctctggtcc atcttgggca ttaggttctc cagcagagct   5880

ctggccagct gcctcttctt taactgggaa cacaggctct cacaagatca gaacccccac   5940

tcacccccaa gatcttatct agcaagcctg tagtattcag tttctgttgt aggaagagag   6000

cgaggcatcc ctgaattcca cgcatctgct ggaaacgagc cgtgtcagat cgcacatccc   6060

tgcgccccca tgcccctctg agtcacacag gacagaggag gcagagcttc tgcccactgt   6120

tatcttcact ttctttgtcc agtcttttgt ttttaataag cagtgaccct ccctactctt   6180

ctttttaatg atttttgtag ttgatttgtc tgaactgtgg ctactgtgca ttccttgaat   6240

aatcacttgt aaaaattgtc agtgcttgaa gctgtttcct ttactcacat tgaagggact   6300

tcgttggttt tttggagtct tggttgtgac tccaagagca gagtgaggaa gacccccaag   6360

catagactcg ggtactgtga tgatggctgc agtccagttt tatgattctg cttttatgtg   6420

tcccttgata acagtgactt aacaatatac attcctcata aataaaaaaa aaacaagaat   6480

ctgaattctt agaaaaaaaa aaaaa                                         6505


<210>  1442
<211>  1181
<212>  PRT
<213>  Homosapiens

<400>  1442

Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu 
    690                 695                 700                 


Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly 
705                 710                 715                 720 


Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu 
                725                 730                 735     


Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala 
            740                 745                 750         


Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala 
        755                 760                 765             


Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly 
    770                 775                 780                 


Phe Thr Glu Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala 
785                 790                 795                 800 


Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro 
                805                 810                 815     


Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp 
            820                 825                 830         


Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys 
        835                 840                 845             


Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys 
    850                 855                 860                 


His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser 
865                 870                 875                 880 


Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu 
                885                 890                 895     


Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe 
            900                 905                 910         


His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp 
        915                 920                 925             


Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr 
    930                 935                 940                 


Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu 
945                 950                 955                 960 


Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr 
                965                 970                 975     


Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser 
            980                 985                 990         


Asp Lys Ile Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
        995                 1000                 1005             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1010                 1015                 1020             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1025                 1030                 1035             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1040                 1045                 1050             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1055                 1060                 1065             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1070                 1075                 1080             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1085                 1090                 1095             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1100                 1105                 1110             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1115                 1120                 1125             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1130                 1135                 1140             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1145                 1150                 1155             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1160                 1165                 1170             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1175                 1180     


<210>  1443
<211>  3075
<212>  DNA
<213>  Homosapiens

<400>  1443
gagccagcga ggagtgaagc tgagcctggc ctcacacgct cctagaggac cacctcctga     60

gagagttctt tcaccccctc ttctttctcc aagctcccct cctgctctcc ctccctgccc    120

aatacaatgc attcttgagt ggcagcgtct ggactccagg cagccccaga gaaccgaagc    180

aagccaaaga gaggactgga gccaagatac tggtggggga gattggatgc ctggctttct    240

ttgaggacat ctttggagcg agggtggctt tggggtgggg gcttgtgctg cagggaatac    300

agccaggccc caagatggac acttctgggc acttccatga ctcgggggtg ggggacttgg    360

atgaagaccc caagtgcccc tgtccatcct ctggggatga gcagcagcag cagcagcagc    420

agcaacagca gcagcagcca ccaccgccag cgccaccagc agccccccag cagcccctgg    480

gaccctcgct gcagcctcag cctccgcagc ttcagcagca gcagcagcag cagcagcagc    540

agcagcagca gcagcagcag cagcagcagc caccgcatcc cctgtctcag ctcgcccaac    600

tccagagcca gcccgtccac cctggcctgc tgcactcctc tcccaccgct ttcagggccc    660

ccccttcgtc caactccacc gccatcctcc acccttcctc caggcaaggc agccagctca    720

atctcaatga ccacttgctt ggccactctc caagttccac agctacaagt gggcctggcg    780

gaggcagccg gcaccgacag gccagccccc tggtgcaccg gcgggacagc aaccccttca    840

cggagatcgc catgagctcc tgcaagtata gcggtggggt catgaagccc ctcagccgcc    900

tcagcgcctc ccggaggaac ctcatcgagg ccgagactga gggccaaccc ctccagcttt    960

tcagccctag caaccccccg gagatcgtca tctcctcccg ggaggacaac catgcccacc   1020

agaccctgct ccatcaccct aatgccaccc acaaccacca gcatgccggc accaccgcca   1080

gcagcaccac cttccccaaa gccaacaagc ggaaaaacca aaacattggc tataagctgg   1140

gacacaggag ggccctgttt gaaaagagaa agcgactgag tgactatgct ctgatttttg   1200

ggatgtttgg aattgttgtt atggtgatag agaccgagct ctcttggggt ttgtactcaa   1260

aggactccat gttttcgttg gccctgaaat gccttatcag tctgtccacc atcatccttt   1320

tgggcttgat catcgcctac cacacacgtg aagtccagct cttcgtgatc gacaatggcg   1380

cggatgactg gcggatagcc atgacctacg agcgcatcct gtacatcagc ctggagatgc   1440

tggtgtgcgc catccacccc attcctggcg agtacaagtt cttctggacg gcacgcctgg   1500

ccttctccta cacaccctcc cgggcggagg ccgatgtgga catcatcctg tctatcccca   1560

tgttcctgcg cctgtacctg atcgcccgag tcatgctgct gcacagcaag ctcttcaccg   1620

atgcctcgtc ccgcagcatc ggggccctca acaagatcaa cttcaacacc cgctttgtca   1680

tgaagacgct catgaccatc tgccctggca ctgtgctgct cgtgttcagc atctctctgt   1740

ggatcattgc tgcctggacc gtccgtgtct gtgaaaggta ccatgaccag caggacgtaa   1800

ctagtaactt tctgggtgcc atgtggctca tctccatcac attcctttcc attggttatg   1860

gggacatggt gccccacaca tactgtggga aaggtgtctg tctcctcact ggcatcatgg   1920

gtgcaggctg cactgccctt gtggtggccg tggtggcccg aaagctggaa ctcaccaaag   1980

cggagaagca cgttcataac ttcatgatgg acactcagct caccaagcgg atcaagaatg   2040

ctgcagccaa tgtccttcgg gaaacatggt taatctataa acacacaaag ctgctaaaga   2100

agattgacca tgccaaagtg aggaaacacc agaggaagtt cctccaagct atccaccagt   2160

tgaggagcgt caagatggaa cagaggaagc tgagtgacca agccaacact ctggtggacc   2220

tttccaagat gcagaatgtc atgtatgact taatcacaga actcaatgac cggagcgaag   2280

acctggagaa gcagattggc agcctggagt cgaagctgga gcatctcacc gccagcttca   2340

actccctgcc gctgctcatc gccgacaccc tgcgccagca gcagcagcag ctcctgtctg   2400

ccatcatcga ggcccggggt gtcagcgtgg cagtgggcac cacccacacc ccaatctccg   2460

atagccccat tggggtcagc tccacctcct tcccgacccc gtacacaagt tcaagcagtt   2520

gctaaataaa tctccccact ccagaagcat tacccatagg tcttaagatg caaatcaact   2580

ctctcctggt cgctttgcca tcaagaaaca ttcagaccag ggaacggaaa gaagagagac   2640

cgagctaatt aactaactca tgttcattca gcgtgcttgg tccgacatgc cttgaaacca   2700

gaaatctaat ctctgtttag gtgcctctac ttgggagcgg gaagaggaga tgacaggaag   2760

cgacgcctct ggcagggccc ttgctgcaga gttggtggag aacagaaatc cacgctcaat   2820

ctcaggtctt cacgcggggg gtgggggtca gatgcactga agtagccaac agcgaagcca   2880

gtccagaaga ggggtccgct gggagggagg gttgtgtcag gcttggggga tgggctcttc   2940

gccatggggg tctttgaaca cacctctctc ctttcctttt gtctacggaa gcctctgggt   3000

gacaaaagta aaagagagct gcccacaact tgccaaaaca gatatactcg aatcagactg   3060

aaaaaaaaaa aaaaa                                                    3075


<210>  1444
<211>  736
<212>  PRT
<213>  Homosapiens

<400>  1444

Met Asp Thr Ser Gly His Phe His Asp Ser Gly Val Gly Asp Leu Asp 
1               5                   10                  15      


Glu Asp Pro Lys Cys Pro Cys Pro Ser Ser Gly Asp Glu Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Ala Pro Pro 
        35                  40                  45              


Ala Ala Pro Gln Gln Pro Leu Gly Pro Ser Leu Gln Pro Gln Pro Pro 
    50                  55                  60                  


Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Pro Pro His Pro Leu Ser Gln Leu Ala Gln Leu 
                85                  90                  95      


Gln Ser Gln Pro Val His Pro Gly Leu Leu His Ser Ser Pro Thr Ala 
            100                 105                 110         


Phe Arg Ala Pro Pro Ser Ser Asn Ser Thr Ala Ile Leu His Pro Ser 
        115                 120                 125             


Ser Arg Gln Gly Ser Gln Leu Asn Leu Asn Asp His Leu Leu Gly His 
    130                 135                 140                 


Ser Pro Ser Ser Thr Ala Thr Ser Gly Pro Gly Gly Gly Ser Arg His 
145                 150                 155                 160 


Arg Gln Ala Ser Pro Leu Val His Arg Arg Asp Ser Asn Pro Phe Thr 
                165                 170                 175     


Glu Ile Ala Met Ser Ser Cys Lys Tyr Ser Gly Gly Val Met Lys Pro 
            180                 185                 190         


Leu Ser Arg Leu Ser Ala Ser Arg Arg Asn Leu Ile Glu Ala Glu Thr 
        195                 200                 205             


Glu Gly Gln Pro Leu Gln Leu Phe Ser Pro Ser Asn Pro Pro Glu Ile 
    210                 215                 220                 


Val Ile Ser Ser Arg Glu Asp Asn His Ala His Gln Thr Leu Leu His 
225                 230                 235                 240 


His Pro Asn Ala Thr His Asn His Gln His Ala Gly Thr Thr Ala Ser 
                245                 250                 255     


Ser Thr Thr Phe Pro Lys Ala Asn Lys Arg Lys Asn Gln Asn Ile Gly 
            260                 265                 270         


Tyr Lys Leu Gly His Arg Arg Ala Leu Phe Glu Lys Arg Lys Arg Leu 
        275                 280                 285             


Ser Asp Tyr Ala Leu Ile Phe Gly Met Phe Gly Ile Val Val Met Val 
    290                 295                 300                 


Ile Glu Thr Glu Leu Ser Trp Gly Leu Tyr Ser Lys Asp Ser Met Phe 
305                 310                 315                 320 


Ser Leu Ala Leu Lys Cys Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu 
                325                 330                 335     


Gly Leu Ile Ile Ala Tyr His Thr Arg Glu Val Gln Leu Phe Val Ile 
            340                 345                 350         


Asp Asn Gly Ala Asp Asp Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile 
        355                 360                 365             


Leu Tyr Ile Ser Leu Glu Met Leu Val Cys Ala Ile His Pro Ile Pro 
    370                 375                 380                 


Gly Glu Tyr Lys Phe Phe Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr 
385                 390                 395                 400 


Pro Ser Arg Ala Glu Ala Asp Val Asp Ile Ile Leu Ser Ile Pro Met 
                405                 410                 415     


Phe Leu Arg Leu Tyr Leu Ile Ala Arg Val Met Leu Leu His Ser Lys 
            420                 425                 430         


Leu Phe Thr Asp Ala Ser Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile 
        435                 440                 445             


Asn Phe Asn Thr Arg Phe Val Met Lys Thr Leu Met Thr Ile Cys Pro 
    450                 455                 460                 


Gly Thr Val Leu Leu Val Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala 
465                 470                 475                 480 


Trp Thr Val Arg Val Cys Glu Arg Tyr His Asp Gln Gln Asp Val Thr 
                485                 490                 495     


Ser Asn Phe Leu Gly Ala Met Trp Leu Ile Ser Ile Thr Phe Leu Ser 
            500                 505                 510         


Ile Gly Tyr Gly Asp Met Val Pro His Thr Tyr Cys Gly Lys Gly Val 
        515                 520                 525             


Cys Leu Leu Thr Gly Ile Met Gly Ala Gly Cys Thr Ala Leu Val Val 
    530                 535                 540                 


Ala Val Val Ala Arg Lys Leu Glu Leu Thr Lys Ala Glu Lys His Val 
545                 550                 555                 560 


His Asn Phe Met Met Asp Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala 
                565                 570                 575     


Ala Ala Asn Val Leu Arg Glu Thr Trp Leu Ile Tyr Lys His Thr Lys 
            580                 585                 590         


Leu Leu Lys Lys Ile Asp His Ala Lys Val Arg Lys His Gln Arg Lys 
        595                 600                 605             


Phe Leu Gln Ala Ile His Gln Leu Arg Ser Val Lys Met Glu Gln Arg 
    610                 615                 620                 


Lys Leu Ser Asp Gln Ala Asn Thr Leu Val Asp Leu Ser Lys Met Gln 
625                 630                 635                 640 


Asn Val Met Tyr Asp Leu Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp 
                645                 650                 655     


Leu Glu Lys Gln Ile Gly Ser Leu Glu Ser Lys Leu Glu His Leu Thr 
            660                 665                 670         


Ala Ser Phe Asn Ser Leu Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln 
        675                 680                 685             


Gln Gln Gln Gln Leu Leu Ser Ala Ile Ile Glu Ala Arg Gly Val Ser 
    690                 695                 700                 


Val Ala Val Gly Thr Thr His Thr Pro Ile Ser Asp Ser Pro Ile Gly 
705                 710                 715                 720 


Val Ser Ser Thr Ser Phe Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
                725                 730                 735     


<210>  1445
<211>  1981
<212>  DNA
<213>  Homosapiens

<400>  1445
ctgctcagtg tcaaattaac aggaaagtca gcttaaagga cactccttgc agggactgag     60

ctggcaccta ctccttagag cttgctgata ccaggcctgc cacgcgacat ctgcaaggac    120

agttgtttgg tgttttgctt caggttatag atggagagac ctataaagga ctccatgttt    180

tcgttggccc tgaaatgcct tatcagtctg tccaccatca tccttttggg cttgatcatc    240

gcctaccaca cacgtgaagt ccagctcttc gtgatcgaca atggcgcgga tgactggcgg    300

atagccatga cctacgagcg catcctgtac atcagcctgg agatgctggt gtgcgccatc    360

caccccattc ctggcgagta caagttcttc tggacggcac gcctggcctt ctcctacaca    420

ccctcccggg cggaggccga tgtggacatc atcctgtcta tccccatgtt cctgcgcctg    480

tacctgatcg cccgagtcat gctgctgcac agcaagctct tcaccgatgc ctcgtcccgc    540

agcatcgggg ccctcaacaa gatcaacttc aacacccgct ttgtcatgaa gacgctcatg    600

accatctgcc ctggcactgt gctgctcgtg ttcagcatct ctctgtggat cattgctgcc    660

tggaccgtcc gtgtctgtga aaggtaccat gaccagcagg acgtaactag taactttctg    720

ggtgccatgt ggctcatctc catcacattc ctttccattg gttatgggga catggtgccc    780

cacacatact gtgggaaagg tgtctgtctc ctcactggca tcatgggtgc aggctgcact    840

gcccttgtgg tggccgtggt ggcccgaaag ctggaactca ccaaagcgga gaagcacgtt    900

cataacttca tgatggacac tcagctcacc aagcggatca agaatgctgc agccaatgtc    960

cttcgggaaa catggttaat ctataaacac acaaagctgc taaagaagat tgaccatgcc   1020

aaagtgagga aacaccagag gaagttcctc caagctatcc accagttgag gagcgtcaag   1080

atggaacaga ggaagctgag tgaccaagcc aacactctgg tggacctttc caagatgcag   1140

aatgtcatgt atgacttaat cacagaactc aatgaccgga gcgaagacct ggagaagcag   1200

attggcagcc tggagtcgaa gctggagcat ctcaccgcca gcttcaactc cctgccgctg   1260

ctcatcgccg acaccctgcg ccagcagcag cagcagctcc tgtctgccat catcgaggcc   1320

cggggtgtca gcgtggcagt gggcaccacc cacaccccaa tctccgatag ccccattggg   1380

gtcagctcca cctccttccc gaccccgtac acaagttcaa gcagttgcta aataaatctc   1440

cccactccag aagcattacc cataggtctt aagatgcaaa tcaactctct cctggtcgct   1500

ttgccatcaa gaaacattca gaccagggaa cggaaagaag agagaccgag ctaattaact   1560

aactcatgtt cattcagcgt gcttggtccg acatgccttg aaaccagaaa tctaatctct   1620

gtttaggtgc ctctacttgg gagcgggaag aggagatgac aggaagcgac gcctctggca   1680

gggcccttgc tgcagagttg gtggagaaca gaaatccacg ctcaatctca ggtcttcacg   1740

cggggggtgg gggtcagatg cactgaagta gccaacagcg aagccagtcc agaagagggg   1800

tccgctggga gggagggttg tgtcaggctt gggggatggg ctcttcgcca tgggggtctt   1860

tgaacacacc tctctccttt ccttttgtct acggaagcct ctgggtgaca aaagtaaaag   1920

agagctgccc acaacttgcc aaaacagata tactcgaatc agactgaaaa aaaaaaaaaa   1980

a                                                                   1981


<210>  1446
<211>  426
<212>  PRT
<213>  Homosapiens

<400>  1446

Met Glu Arg Pro Ile Lys Asp Ser Met Phe Ser Leu Ala Leu Lys Cys 
1               5                   10                  15      


Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala Tyr 
            20                  25                  30          


His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp Asp 
        35                  40                  45              


Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu Glu 
    50                  55                  60                  


Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe Phe 
65                  70                  75                  80  


Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu Ala 
                85                  90                  95      


Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu 
            100                 105                 110         


Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser 
        115                 120                 125             


Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe 
    130                 135                 140                 


Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val 
145                 150                 155                 160 


Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val Cys 
                165                 170                 175     


Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala 
            180                 185                 190         


Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
        195                 200                 205             


Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
    210                 215                 220                 


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
225                 230                 235                 240 


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
                245                 250                 255     


Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu Arg 
            260                 265                 270         


Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile Asp 
        275                 280                 285             


His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
    290                 295                 300                 


Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln Ala 
305                 310                 315                 320 


Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp Leu 
                325                 330                 335     


Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile Gly 
            340                 345                 350         


Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser Leu 
        355                 360                 365             


Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu Leu 
    370                 375                 380                 


Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr Thr 
385                 390                 395                 400 


His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser Phe 
                405                 410                 415     


Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
            420                 425     


<210>  1447
<211>  2369
<212>  DNA
<213>  Homosapiens

<400>  1447
gcggccgcaa gccgtcgccc cctttaagag cctgctccgc gggactaacg ttcgaacggg     60

ccctggcgcc cctcctcggg ctccgattgg ccgtgcgcgg cgcacgaggg cgcgccggcc    120

agccccggaa cggttggcgg cccttcgtga ttggcggtcg agaagcctat ataaggcgcg    180

gggcagccag gctgccctgt ttagcgaccg gacccgaaac ggggaagttg tcttgtttgg    240

agaggttagt agagcagcgc gcgcgtcacc agagtcgttt ctcttcggag tcttaggtga    300

tcgagggtgt gcccaggggg cggacttgtt tgcgcctccc gttccctccc aatttccaaa    360

cgtgtcaccc cggcgccgac ggccctgtgc aggggaagca gatggagttc aagctggagg    420

ctcatcgcat cgtcagcatc tctctgggca agatctacaa ctcgcgggtc cagcgcggcg    480

gcatcaagct gcataagaac ctcctggtct cgctggtgct gcgcagcgcc cgccaagtct    540

acctgagcga cccgtgcccc ggcctctacc tggccggtcc cgctgggacc ccggcgccgc    600

caccgcagca gcagcccggg gagccggcgg ccgggccacc cgccggctgg ggagagccgc    660

ccccgcccgc cgctcgtgcc tcttggccgg agaccgagcc gcagccggag cgctcctccg    720

tctcagacgc gccgcgggta ggggacgagg tgccggtggc cacggtgact ggagtcgggg    780

acgtttttca gggcggagag gcggacgcga cggaagctgc ctggagccgc gtggaggggc    840

cgcgccaggc ggcggccaga gaagccgagg gtaccgccgg aggctggggc gtcttccccg    900

aggtatctcg tgccgcgcgc cgcccctgcg gctgccccct aggcggggag gacccgccgg    960

gtacaccggc cgcgaccccc cgcgctgcct gctgctgcgc gccgcgacca gcggaggacg   1020

agccccccgc gccgcccgcg gtgtgcccca ggaagcgctg cgcggcgggg gtgggcggcg   1080

gcccagcggg ctgcccggcg cccggctcga ccccgctcaa gaagccccgc cggaacttag   1140

agcagccgcc gagtggagga gaggacgacg acgcggagga gatggagacc gggaacgtgg   1200

ctaacctcat cagcatcttc ggttccagtt tctcgggact cctacggaaa agccccgggg   1260

gcggcagaga ggaagaggag ggagaggaga gcggtccgga agccgccgag cccgggcaga   1320

tctgctgcga taagccggtg ctgagagaca tgaacccctg gagcacagcc atcgtggcct   1380

tctgagccct tggcccccct gcggggagga ggtggagcag cgggcgtccc cgaagtgagg   1440

gccaggccct tcccggctgc gaggacgccc agagaccgcg ggcgctgagc gcgttgggca   1500

gactggttgc ctctgggcat cgcaaactgc ccccgggcgc atctggctta tctggagacc   1560

tgggagcttg aggctcattg gaagaggacg atcgttaact tttgtgtttg tgtatgtctg   1620

tgtatgtaag tttgtcttgt ggcattaaga ctattttgct cttctggaat gcaccactcc   1680

ttccccaggg tttaagagat tgggggcaga cagggacttt cctctgccgg ctgcgtggag   1740

aaggaagcgg ctaaaaggtt tgggccgggg agttccccat tcgttctccg gggagggagg   1800

gactttacac ctacccctca ccggaaagct agacccgctt cagggccagg agtggcgttt   1860

ccgcacagga tttcctaaga cgagagggat ttagccaaga gcacagactt ggattccttc   1920

tgtccctccc cacctttctc tcccaatgaa gaaacgttta tatcctgtga ttactctagg   1980

aaaggggcgt attaacggtc ctttgcttcc ccgcagggga gaaaaagctt gacgaacttc   2040

acagaagagt tcaagcttgg aaataatgga gtttatagag aaaagatata tttttaaaag   2100

ctctaggtca gaagtactac acagtgcttt taaaaagtgt ttaatgagag tttacagaca   2160

gaagcccgaa gtggaaagac cttatggttt tgtagatatg gtgactccag tctttgttgt   2220

ataaaggttg ggggagctga taaggttttt gtacagtatt ttctccttcg ttgtattgat   2280

ttttgtataa aaatgtaact tctacgtgtc taacacgtat taaatatttt gaagcaaaaa   2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     2369


<210>  1448
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1448

Met Glu Phe Lys Leu Glu Ala His Arg Ile Val Ser Ile Ser Leu Gly 
1               5                   10                  15      


Lys Ile Tyr Asn Ser Arg Val Gln Arg Gly Gly Ile Lys Leu His Lys 
            20                  25                  30          


Asn Leu Leu Val Ser Leu Val Leu Arg Ser Ala Arg Gln Val Tyr Leu 
        35                  40                  45              


Ser Asp Pro Cys Pro Gly Leu Tyr Leu Ala Gly Pro Ala Gly Thr Pro 
    50                  55                  60                  


Ala Pro Pro Pro Gln Gln Gln Pro Gly Glu Pro Ala Ala Gly Pro Pro 
65                  70                  75                  80  


Ala Gly Trp Gly Glu Pro Pro Pro Pro Ala Ala Arg Ala Ser Trp Pro 
                85                  90                  95      


Glu Thr Glu Pro Gln Pro Glu Arg Ser Ser Val Ser Asp Ala Pro Arg 
            100                 105                 110         


Val Gly Asp Glu Val Pro Val Ala Thr Val Thr Gly Val Gly Asp Val 
        115                 120                 125             


Phe Gln Gly Gly Glu Ala Asp Ala Thr Glu Ala Ala Trp Ser Arg Val 
    130                 135                 140                 


Glu Gly Pro Arg Gln Ala Ala Ala Arg Glu Ala Glu Gly Thr Ala Gly 
145                 150                 155                 160 


Gly Trp Gly Val Phe Pro Glu Val Ser Arg Ala Ala Arg Arg Pro Cys 
                165                 170                 175     


Gly Cys Pro Leu Gly Gly Glu Asp Pro Pro Gly Thr Pro Ala Ala Thr 
            180                 185                 190         


Pro Arg Ala Ala Cys Cys Cys Ala Pro Arg Pro Ala Glu Asp Glu Pro 
        195                 200                 205             


Pro Ala Pro Pro Ala Val Cys Pro Arg Lys Arg Cys Ala Ala Gly Val 
    210                 215                 220                 


Gly Gly Gly Pro Ala Gly Cys Pro Ala Pro Gly Ser Thr Pro Leu Lys 
225                 230                 235                 240 


Lys Pro Arg Arg Asn Leu Glu Gln Pro Pro Ser Gly Gly Glu Asp Asp 
                245                 250                 255     


Asp Ala Glu Glu Met Glu Thr Gly Asn Val Ala Asn Leu Ile Ser Ile 
            260                 265                 270         


Phe Gly Ser Ser Phe Ser Gly Leu Leu Arg Lys Ser Pro Gly Gly Gly 
        275                 280                 285             


Arg Glu Glu Glu Glu Gly Glu Glu Ser Gly Pro Glu Ala Ala Glu Pro 
    290                 295                 300                 


Gly Gln Ile Cys Cys Asp Lys Pro Val Leu Arg Asp Met Asn Pro Trp 
305                 310                 315                 320 


Ser Thr Ala Ile Val Ala Phe 
                325         


<210>  1449
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1449
gctgctgctg cctctccgaa gagctcgcgg agctccccag aggcggtggt ccccgtgctt     60

gtctggatgc ggctctgagt ctccgtgtgt ctttctgctt gttgctgtgt gcgggtgttc    120

ggccgcgatc acctttgtgt gtcttctgtc tgtttaaacc tcaggatggc tcgcttcggg    180

gaggcggtgg tcgccaggcc agggtccggc gatggagact cggaccagag caggaaccgg    240

caaggaaccc ccgtgccggc ctcggggcag gcggccgcct acaagcagac gaaagcacag    300

agggcgcgga ctatggcttt gtacaacccc attcccgtcc ggcagaactg tttcaccgtc    360

aacagatccc tgttcatctt cggagaagat aacattgtca ggaaatatgc caagaagctc    420

atcgattggc cgccatttga gtacatgatc ctggccacca tcattgccaa ctgcatcgtc    480

ctggccctgg agcagcatct tcctgaggat gacaagaccc ccatgtcccg aagactggag    540

aagacagaac cttatttcat tgggatcttt tgctttgaag ctgggatcaa aattgtggcc    600

ctggggttca tcttccataa gggctcttac ctccgcaatg gctggaatgt catggacttc    660

atcgtggtcc tcagtggcat cctggccact gcaggaaccc acttcaatac tcacgtggac    720

ctgaggaccc tccgggctgt gcgtgtcctg cggcctttga agctcgtgtc agggatacct    780

agcctgcaga ttgtgttgaa gtccatcatg aaggccatgg tacctcttct gcagattggc    840

cttctgctct tctttgccat cctgatgttt gctatcattg gtttggagtt ctacagtggc    900

aagttacatc gagcatgctt catgaacaat tcaggtattc tagaaggatt tgacccccct    960

cacccatgtg gtgtgcaggg ctgcccagct ggttatgaat gcaaggactg gatcggcccc   1020

aatgatggga tcacccagtt tgataacatc ctttttgctg tgctgactgt cttccagtgc   1080

atcaccatgg aagggtggac cactgtgctg tacaatacca atgatgcctt aggagccacc   1140

tggaattggc tgtacttcat ccccctcatc atcattggat ccttctttgt tctcaaccta   1200

gtcctgggag tgctttccgg ggaatttgcc aaagagagag agagagtgga gaaccgaagg   1260

gctttcatga agctgcggcg ccagcagcag attgagcgtg agctgaatgg ctaccgtgcc   1320

tggatagaca aagcagagga agtcatgctc gctgaagaaa ataaaaatgc tggaacatcc   1380

gccttagaag tgcttcgaag ggcaaccatc aagaggagcc ggacagaggc catgactcga   1440

gactccagtg atgagcactg tgttgatatc tcctctgtgg gcacacctct ggcccgagcc   1500

agtatcaaaa gtgcaaaggt agacggggtc tcttatttcc ggcacaagga aaggcttctg   1560

cgcatctcca ttcgccacat ggttaaatcc caggtgtttt actggattgt gctgagcctt   1620

gtggcactca acactgcctg tgtggccatt gtccatcaca accagcccca gtggctcacc   1680

cacctcctct actatgcaga atttctgttt ctgggactct tcctcttgga gatgtccctg   1740

aagatgtatg gcatggggcc tcgcctttat tttcactctt cattcaactg ctttgatttt   1800

ggggtcacag tgggcagtat ctttgaagtg gtctgggcaa tcttcagacc tggtacgtct   1860

tttggaatca gtgtcttgcg agccctccgg cttctaagaa tatttaaaat aaccaagtat   1920

tgggcttccc tacggaattt ggtggtctcc ttgatgagct caatgaagtc tatcatcagt   1980

ttgcttttcc tcctcttcct cttcatcgtt gtctttgctc tcctaggaat gcagttattt   2040

ggaggcaggt ttaactttaa tgatgggact ccttcggcaa attttgatac cttccctgca   2100

gccatcatga ctgtgttcca gatcctgacg ggtgaggact ggaatgaggt gatgtacaat   2160

gggatccgct cccagggtgg ggtcagctca ggcatgtggt ctgccatcta cttcattgtg   2220

ctcaccttgt ttggcaacta cacgctactg aatgtgttct tggctatcgc tgtggataat   2280

ctcgccaacg cccaggaact gaccaaggat gaacaggagg aagaagaggc cttcaaccag   2340

aaacatgcac tgcagaaggc caaggaggtc agcccgatgt ctgcacccaa catgccttcg   2400

atcgaaagag acagaaggag aagacaccac atgtcgatgt gggagccacg cagcagccac   2460

ctgagggagc ggaggcgccg gcaccacatg tccgtgtggg agcagcgtac cagccagctg   2520

aggaagcaca tgcagatgtc cagccaggag gccctcaaca gagaggaggc gccgaccatg   2580

aacccgctca accccctcaa cccgctcagc tccctcaacc cgctcaatgc ccaccccagc   2640

ctttatcggc gacccagggc cattgagggc ctggccctgg gcctggccct ggagaagttc   2700

gaggaggagc gcatcagccg tggggggtcc ctcaaggggg atggagggga ccgatccagt   2760

gccctggaca accagaggac ccctttgtcc ctgggccagc gggagccacc atggctggcc   2820

aggccctgtc atggaaactg tgacccgact cagcaggagg cagggggagg agaggctgtg   2880

gtgacctttg aggaccgggc caggcacagg cagagccaac ggcgcagccg gcatcgccgc   2940

gtcaggacag aaggcaagga gtcctcttca gcctcccgga gcaggtctgc cagccaggaa   3000

cgcagtctgg atgaagccat gcccactgaa ggggagaagg accatgagct caggggcaac   3060

catggtgcca aggagccaac gatccaagaa gagagagccc aggatttaag gaggaccaac   3120

agtctgatgg tgtccagagg ctccgggctg gcaggaggcc ttgatgaggc tgacaccccc   3180

ctagtcctgc cccatcctga gctggaagtg gggaagcacg tggtgctgac ggagcaggag   3240

ccagaaggca gcagtgagca ggccctgctg gggaatgtgc agctagacat gggccgggtc   3300

atcagccaga gcgagcctga cctctcctgc atcacggcca acacggacaa ggccaccacc   3360

gagagcacca gcgtcaccgt cgccatcccc gacgtggacc ccttggtgga ctcaaccgtg   3420

gtgcacatta gcaacaagac ggatggggaa gccagtccct tgaaggaggc agagatcaga   3480

gaggatgagg aggaggtgga gaagaagaag cagaagaagg agaagcgtga gacaggcaaa   3540

gccatggtgc cccacagctc aatgttcatc ttcagcacca ccaacccgat ccggagggcc   3600

tgccactaca tcgtgaacct gcgctacttt gagatgtgca tcctcctggt gattgcagcc   3660

agcagcatcg ccctggcggc agaggacccc gtcctgacca actcggagcg caacaaagtc   3720

ctgaggtatt ttgactatgt gttcacgggc gtgttcacct ttgagatggt tataaagatg   3780

atagaccaag gcttgatcct gcaggatggg tcctacttcc gagacttgtg gaacatcctg   3840

gactttgtgg tggtcgttgg cgcattggtg gcctttgctc tggcgaacgc tttgggaacc   3900

aacaaaggac gggacatcaa gaccatcaag tctctgcggg tgctccgagt tctaaggcca   3960

ctgaaaacca tcaagcgctt gcccaagctc aaggccgtct tcgactgcgt agtgacctcc   4020

ttgaagaatg tcttcaacat actcattgtg tacaagctct tcatgttcat ctttgctgtc   4080

atcgcagttc agctcttcaa gggaaagttc ttttattgca cggacagttc caaggacaca   4140

gagaaggagt gcataggcaa ctatgtagat catgagaaaa acaagatgga ggtgaagggc   4200

cgggaatgga agcgccatga attccactac gacaacatta tctgggccct gctgaccctc   4260

ttcaccgtct ccacagggga aggatggcct caagttctgc agcactctgt agatgtgaca   4320

gaggaagacc gaggcccaag ccgcagcaac cgcatggaga tgtctatctt ttatgtagtc   4380

tactttgtgg tcttcccctt cttctttgtc aatatctttg tggctctcat catcatcacc   4440

ttccaggagc aaggggataa gatgatggag gagtgcagcc tggagaagaa tgagagggcg   4500

tgcatcgact tcgccatcag cgccaaacct ctcacccgct acatgccgca gaacagacac   4560

accttccagt accgcgtgtg gcactttgtg gtgtctccgt cctttgagta caccattatg   4620

gccatgatcg ccttgaatac tgttgtgctg atgatgaagt attattctgc tccctgtacc   4680

tatgagctgg ccctgaagta cctgaatatc gccttcacca tggtgttttc cctggaatgt   4740

gtcctgaagg tcatcgcttt tggctttttg aactatttcc gagacacctg gaatatcttt   4800

gacttcatca ccgtgattgg cagtatcaca gaaattatcc tgacagacag caagctggtg   4860

aacaccagtg gcttcaatat gagctttctg aagctcttcc gagctgcccg cctcataaag   4920

ctcctgcgtc agggctatac catacgcatt ttgctgtgga cctttgtgca gtcctttaag   4980

gccctccctt atgtctgcct tttaattgcc atgcttttct tcatttatgc catcattggg   5040

atgcaggtat ttggaaacat aaaattagac gaggagagtc acatcaaccg gcacaacaac   5100

ttccggagtt tctttgggtc cctaatgcta ctcttcagga gtgccacagg tgaggcctgg   5160

caggagatta tgctgtcatg ccttggggag aagggctgtg agcctgacac caccgcacca   5220

tcagggcaga acgagaacga acgctgcggc accgatctgg cctacgtgta ctttgtctcc   5280

ttcatcttct tctgctcctt cttgatgctc aacctgtttg tggccgtcat catggacaac   5340

tttgagtacc tgactcggga ctcctccatc ctggggcctc accacttgga cgagtttgtc   5400

cgcgtctggg cagaatatga ccgagcagca tgtggccgca tccattacac tgagatgtat   5460

gaaatgctga ctctcatgtc acctccgcta ggcctcggca agagatgtcc ctccaaagtg   5520

gcatataaga ggttggtcct gatgaacatg ccagtagctg aggacatgac ggtccacttc   5580

acctccacac ttatggctct gatccggaca gctctggaca ttaaaattgc caaaggtggt   5640

gcagacaggc agcagctaga ctcagagcta caaaaggaga ccctagccat ctggcctcac   5700

ctatcccaga agatgctgga tctgcttgtg cccatgccca aagcctctga cctgactgtg   5760

ggcaaaatct atgcagcaat gatgatcatg gactactata agcagagtaa ggtgaagaag   5820

cagaggcagc agctggagga acagaaaaat gcccccatgt tccagcgcat ggagccttca   5880

tctctgcctc aggagatcat tgctaatgcc aaagccctgc cttacctcca gcaggacccc   5940

gtttcaggcc tgagtggccg gagtggatac ccttcgatga gtccactctc tccccaggat   6000

atattccagt tggcttgtat ggaccccgcc gatgacggac agttccaaga acggcagtct   6060

ctggtggtga cagaccctag ctccatgaga cgttcatttt ccactattcg ggataagcgt   6120

tcaaattcct cgtggttgga ggaattctcc atggagcgaa gcagtgaaaa tacctacaag   6180

tcccgtcgcc ggagttacca ctcctccttg cggctgtcag cccaccgcct gaactctgat   6240

tcaggccaca agtctgacac tcaccgctca gggggcaggg agcggggacg atcaaaagag   6300

cgaaagcatc ttctctctcc tgatgtctcc cgctgcaatt cagaagagcg agggacccag   6360

gctgactggg agtccccaga gcgccgtcaa tccaggtcac ccagtgaggg caggtcacag   6420

acgcccaaca gacagggcac aggttcccta agtgagagct ccatcccctc tgtctctgac   6480

accagcaccc caagaagaag tcgtcggcag ctcccacccg tcccgccaaa gccccggccc   6540

ctcctttcct acagctccct gattcgacac gcgggcagca tctctccacc tgctgatgga   6600

agcgaggagg gctccccgct gacctcccaa gctctggaga gcaacaatgc ttgcctgacc   6660

gagtcttcca actctccgca cccccagcag agccaacatg cctccccaca gcgctacatc   6720

tccgagccct acttggccct gcacgaagac tcccacgcct cagactgtgg tgaggaggag   6780

acgctcactt tcgaagcagc cgtggctact agcctgggcc gttccaacac catcggctca   6840

gccccacccc tgcggcatag ctggcagatg cccaacgggc actatcggcg gcggaggcgc   6900

ggggggcctg ggccaggcat gatgtgtggg gctgtcaaca acctgctaag tgacacggaa   6960

gaagatgaca aatgctagag gctgctcccc cctccgatgc atgctcttct ctcacatgga   7020

gaaaaccaag acagaattgg gaagccagtg cggcccgggg gggaggaaga gggaaaagga   7080

agatggaagg acaccatgca ttatcagaga agaggaagta aaggacaatc agaacaccag   7140

tcaaacccac caaattgctt tattcccctt tgcaagatgg gcactgccat agttctgcct   7200

ctttgctggg gaaagaaacc aggaacgtgg agggttatta ctgcgggaga agggacacga   7260

ggatggcttt gcttcccctt gccccttccc acttttctaa aagctgtgga gggatctagc   7320

tggcctatgt ctacactcag tgccctgaga agcctggaag actttctggc tcttaactgg   7380

ggagtagtgg agaccatagg agaggactct cctccctcac cagctcttac gcctcagcca   7440

gcaccactgc caccagggca actgcagcag catctcatgc ataaccctgt ggcttgcttc   7500

ccccagggca gcacaggcta agtcaggaac atcggatgcc agggagggag gagaaagccg   7560

aagcgaaagg ggtcagggtg ctgaggcaac agcagcaagg gctggtctgg acaagaaaag   7620

ccatagcccg gcagccccta ccatgaggga gacagagaaa cagaactggt ggtgctgggg   7680

ggtatagccc cccatccttg aggcctgtca cccacacagt aggtgctgag agttaggaca   7740

ggtcaggaag tcccccaggg tccacaaagg tgcctgaggc tctggtaagg gtgaagataa   7800

aagtatttaa caaccgctat ggcatcaatg taagtggagt ttggtcctag tgccggagcc   7860

catgctattc caggcattgg ctctttagat gccagtcatg ggggaaccct gagggtgtgg   7920

gtagagtagc aggggccacc taagagatta aaaacagtct gttttccaac cagtgtggaa   7980

gcaattaaat atgcgtaaca gtgctacggc cacaccagca cctcctggct gaaggtcagc   8040

ccacactctg gtccatgagg cagcaaggcc agtgctgtgc caagcccggt aaggccaagt   8100

gccgaggccc agccttccct gccactcctc tgagagggca gaacacacat atccaagtag   8160

gctacccacc actgggtagg gatttctgta aa                                 8192


<210>  1450
<211>  2270
<212>  PRT
<213>  Homosapiens

<400>  1450

Met Ala Arg Phe Gly Glu Ala Val Val Ala Arg Pro Gly Ser Gly Asp 
1               5                   10                  15      


Gly Asp Ser Asp Gln Ser Arg Asn Arg Gln Gly Thr Pro Val Pro Ala 
            20                  25                  30          


Ser Gly Gln Ala Ala Ala Tyr Lys Gln Thr Lys Ala Gln Arg Ala Arg 
        35                  40                  45              


Thr Met Ala Leu Tyr Asn Pro Ile Pro Val Arg Gln Asn Cys Phe Thr 
    50                  55                  60                  


Val Asn Arg Ser Leu Phe Ile Phe Gly Glu Asp Asn Ile Val Arg Lys 
65                  70                  75                  80  


Tyr Ala Lys Lys Leu Ile Asp Trp Pro Pro Phe Glu Tyr Met Ile Leu 
                85                  90                  95      


Ala Thr Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu 
            100                 105                 110         


Pro Glu Asp Asp Lys Thr Pro Met Ser Arg Arg Leu Glu Lys Thr Glu 
        115                 120                 125             


Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Val 
    130                 135                 140                 


Ala Leu Gly Phe Ile Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp 
145                 150                 155                 160 


Asn Val Met Asp Phe Ile Val Val Leu Ser Gly Ile Leu Ala Thr Ala 
                165                 170                 175     


Gly Thr His Phe Asn Thr His Val Asp Leu Arg Thr Leu Arg Ala Val 
            180                 185                 190         


Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser Leu Gln 
        195                 200                 205             


Ile Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu Gln Ile 
    210                 215                 220                 


Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile Gly Leu 
225                 230                 235                 240 


Glu Phe Tyr Ser Gly Lys Leu His Arg Ala Cys Phe Met Asn Asn Ser 
                245                 250                 255     


Gly Ile Leu Glu Gly Phe Asp Pro Pro His Pro Cys Gly Val Gln Gly 
            260                 265                 270         


Cys Pro Ala Gly Tyr Glu Cys Lys Asp Trp Ile Gly Pro Asn Asp Gly 
        275                 280                 285             


Ile Thr Gln Phe Asp Asn Ile Leu Phe Ala Val Leu Thr Val Phe Gln 
    290                 295                 300                 


Cys Ile Thr Met Glu Gly Trp Thr Thr Val Leu Tyr Asn Thr Asn Asp 
305                 310                 315                 320 


Ala Leu Gly Ala Thr Trp Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile 
                325                 330                 335     


Ile Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly 
            340                 345                 350         


Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn Arg Arg Ala Phe Met 
        355                 360                 365             


Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu Leu Asn Gly Tyr Arg 
    370                 375                 380                 


Ala Trp Ile Asp Lys Ala Glu Glu Val Met Leu Ala Glu Glu Asn Lys 
385                 390                 395                 400 


Asn Ala Gly Thr Ser Ala Leu Glu Val Leu Arg Arg Ala Thr Ile Lys 
                405                 410                 415     


Arg Ser Arg Thr Glu Ala Met Thr Arg Asp Ser Ser Asp Glu His Cys 
            420                 425                 430         


Val Asp Ile Ser Ser Val Gly Thr Pro Leu Ala Arg Ala Ser Ile Lys 
        435                 440                 445             


Ser Ala Lys Val Asp Gly Val Ser Tyr Phe Arg His Lys Glu Arg Leu 
    450                 455                 460                 


Leu Arg Ile Ser Ile Arg His Met Val Lys Ser Gln Val Phe Tyr Trp 
465                 470                 475                 480 


Ile Val Leu Ser Leu Val Ala Leu Asn Thr Ala Cys Val Ala Ile Val 
                485                 490                 495     


His His Asn Gln Pro Gln Trp Leu Thr His Leu Leu Tyr Tyr Ala Glu 
            500                 505                 510         


Phe Leu Phe Leu Gly Leu Phe Leu Leu Glu Met Ser Leu Lys Met Tyr 
        515                 520                 525             


Gly Met Gly Pro Arg Leu Tyr Phe His Ser Ser Phe Asn Cys Phe Asp 
    530                 535                 540                 


Phe Gly Val Thr Val Gly Ser Ile Phe Glu Val Val Trp Ala Ile Phe 
545                 550                 555                 560 


Arg Pro Gly Thr Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu 
                565                 570                 575     


Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu 
            580                 585                 590         


Val Val Ser Leu Met Ser Ser Met Lys Ser Ile Ile Ser Leu Leu Phe 
        595                 600                 605             


Leu Leu Phe Leu Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu 
    610                 615                 620                 


Phe Gly Gly Arg Phe Asn Phe Asn Asp Gly Thr Pro Ser Ala Asn Phe 
625                 630                 635                 640 


Asp Thr Phe Pro Ala Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly 
                645                 650                 655     


Glu Asp Trp Asn Glu Val Met Tyr Asn Gly Ile Arg Ser Gln Gly Gly 
            660                 665                 670         


Val Ser Ser Gly Met Trp Ser Ala Ile Tyr Phe Ile Val Leu Thr Leu 
        675                 680                 685             


Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp 
    690                 695                 700                 


Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Phe Asn Gln Lys His Ala Leu Gln Lys Ala Lys Glu Val Ser 
                725                 730                 735     


Pro Met Ser Ala Pro Asn Met Pro Ser Ile Glu Arg Asp Arg Arg Arg 
            740                 745                 750         


Arg His His Met Ser Met Trp Glu Pro Arg Ser Ser His Leu Arg Glu 
        755                 760                 765             


Arg Arg Arg Arg His His Met Ser Val Trp Glu Gln Arg Thr Ser Gln 
    770                 775                 780                 


Leu Arg Lys His Met Gln Met Ser Ser Gln Glu Ala Leu Asn Arg Glu 
785                 790                 795                 800 


Glu Ala Pro Thr Met Asn Pro Leu Asn Pro Leu Asn Pro Leu Ser Ser 
                805                 810                 815     


Leu Asn Pro Leu Asn Ala His Pro Ser Leu Tyr Arg Arg Pro Arg Ala 
            820                 825                 830         


Ile Glu Gly Leu Ala Leu Gly Leu Ala Leu Glu Lys Phe Glu Glu Glu 
        835                 840                 845             


Arg Ile Ser Arg Gly Gly Ser Leu Lys Gly Asp Gly Gly Asp Arg Ser 
    850                 855                 860                 


Ser Ala Leu Asp Asn Gln Arg Thr Pro Leu Ser Leu Gly Gln Arg Glu 
865                 870                 875                 880 


Pro Pro Trp Leu Ala Arg Pro Cys His Gly Asn Cys Asp Pro Thr Gln 
                885                 890                 895     


Gln Glu Ala Gly Gly Gly Glu Ala Val Val Thr Phe Glu Asp Arg Ala 
            900                 905                 910         


Arg His Arg Gln Ser Gln Arg Arg Ser Arg His Arg Arg Val Arg Thr 
        915                 920                 925             


Glu Gly Lys Glu Ser Ser Ser Ala Ser Arg Ser Arg Ser Ala Ser Gln 
    930                 935                 940                 


Glu Arg Ser Leu Asp Glu Ala Met Pro Thr Glu Gly Glu Lys Asp His 
945                 950                 955                 960 


Glu Leu Arg Gly Asn His Gly Ala Lys Glu Pro Thr Ile Gln Glu Glu 
                965                 970                 975     


Arg Ala Gln Asp Leu Arg Arg Thr Asn Ser Leu Met Val Ser Arg Gly 
            980                 985                 990         


Ser Gly Leu Ala Gly Gly Leu Asp  Glu Ala Asp Thr Pro  Leu Val Leu 
        995                 1000                 1005             


Pro His  Pro Glu Leu Glu Val  Gly Lys His Val Val  Leu Thr Glu 
    1010                 1015                 1020             


Gln Glu  Pro Glu Gly Ser Ser  Glu Gln Ala Leu Leu  Gly Asn Val 
    1025                 1030                 1035             


Gln Leu  Asp Met Gly Arg Val  Ile Ser Gln Ser Glu  Pro Asp Leu 
    1040                 1045                 1050             


Ser Cys  Ile Thr Ala Asn Thr  Asp Lys Ala Thr Thr  Glu Ser Thr 
    1055                 1060                 1065             


Ser Val  Thr Val Ala Ile Pro  Asp Val Asp Pro Leu  Val Asp Ser 
    1070                 1075                 1080             


Thr Val  Val His Ile Ser Asn  Lys Thr Asp Gly Glu  Ala Ser Pro 
    1085                 1090                 1095             


Leu Lys  Glu Ala Glu Ile Arg  Glu Asp Glu Glu Glu  Val Glu Lys 
    1100                 1105                 1110             


Lys Lys  Gln Lys Lys Glu Lys  Arg Glu Thr Gly Lys  Ala Met Val 
    1115                 1120                 1125             


Pro His  Ser Ser Met Phe Ile  Phe Ser Thr Thr Asn  Pro Ile Arg 
    1130                 1135                 1140             


Arg Ala  Cys His Tyr Ile Val  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1145                 1150                 1155             


Ile Leu  Leu Val Ile Ala Ala  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1160                 1165                 1170             


Asp Pro  Val Leu Thr Asn Ser  Glu Arg Asn Lys Val  Leu Arg Tyr 
    1175                 1180                 1185             


Phe Asp  Tyr Val Phe Thr Gly  Val Phe Thr Phe Glu  Met Val Ile 
    1190                 1195                 1200             


Lys Met  Ile Asp Gln Gly Leu  Ile Leu Gln Asp Gly  Ser Tyr Phe 
    1205                 1210                 1215             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Val Val Val  Val Gly Ala 
    1220                 1225                 1230             


Leu Val  Ala Phe Ala Leu Ala  Asn Ala Leu Gly Thr  Asn Lys Gly 
    1235                 1240                 1245             


Arg Asp  Ile Lys Thr Ile Lys  Ser Leu Arg Val Leu  Arg Val Leu 
    1250                 1255                 1260             


Arg Pro  Leu Lys Thr Ile Lys  Arg Leu Pro Lys Leu  Lys Ala Val 
    1265                 1270                 1275             


Phe Asp  Cys Val Val Thr Ser  Leu Lys Asn Val Phe  Asn Ile Leu 
    1280                 1285                 1290             


Ile Val  Tyr Lys Leu Phe Met  Phe Ile Phe Ala Val  Ile Ala Val 
    1295                 1300                 1305             


Gln Leu  Phe Lys Gly Lys Phe  Phe Tyr Cys Thr Asp  Ser Ser Lys 
    1310                 1315                 1320             


Asp Thr  Glu Lys Glu Cys Ile  Gly Asn Tyr Val Asp  His Glu Lys 
    1325                 1330                 1335             


Asn Lys  Met Glu Val Lys Gly  Arg Glu Trp Lys Arg  His Glu Phe 
    1340                 1345                 1350             


His Tyr  Asp Asn Ile Ile Trp  Ala Leu Leu Thr Leu  Phe Thr Val 
    1355                 1360                 1365             


Ser Thr  Gly Glu Gly Trp Pro  Gln Val Leu Gln His  Ser Val Asp 
    1370                 1375                 1380             


Val Thr  Glu Glu Asp Arg Gly  Pro Ser Arg Ser Asn  Arg Met Glu 
    1385                 1390                 1395             


Met Ser  Ile Phe Tyr Val Val  Tyr Phe Val Val Phe  Pro Phe Phe 
    1400                 1405                 1410             


Phe Val  Asn Ile Phe Val Ala  Leu Ile Ile Ile Thr  Phe Gln Glu 
    1415                 1420                 1425             


Gln Gly  Asp Lys Met Met Glu  Glu Cys Ser Leu Glu  Lys Asn Glu 
    1430                 1435                 1440             


Arg Ala  Cys Ile Asp Phe Ala  Ile Ser Ala Lys Pro  Leu Thr Arg 
    1445                 1450                 1455             


Tyr Met  Pro Gln Asn Arg His  Thr Phe Gln Tyr Arg  Val Trp His 
    1460                 1465                 1470             


Phe Val  Val Ser Pro Ser Phe  Glu Tyr Thr Ile Met  Ala Met Ile 
    1475                 1480                 1485             


Ala Leu  Asn Thr Val Val Leu  Met Met Lys Tyr Tyr  Ser Ala Pro 
    1490                 1495                 1500             


Cys Thr  Tyr Glu Leu Ala Leu  Lys Tyr Leu Asn Ile  Ala Phe Thr 
    1505                 1510                 1515             


Met Val  Phe Ser Leu Glu Cys  Val Leu Lys Val Ile  Ala Phe Gly 
    1520                 1525                 1530             


Phe Leu  Asn Tyr Phe Arg Asp  Thr Trp Asn Ile Phe  Asp Phe Ile 
    1535                 1540                 1545             


Thr Val  Ile Gly Ser Ile Thr  Glu Ile Ile Leu Thr  Asp Ser Lys 
    1550                 1555                 1560             


Leu Val  Asn Thr Ser Gly Phe  Asn Met Ser Phe Leu  Lys Leu Phe 
    1565                 1570                 1575             


Arg Ala  Ala Arg Leu Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile 
    1580                 1585                 1590             


Arg Ile  Leu Leu Trp Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro 
    1595                 1600                 1605             


Tyr Val  Cys Leu Leu Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile 
    1610                 1615                 1620             


Ile Gly  Met Gln Val Phe Gly  Asn Ile Lys Leu Asp  Glu Glu Ser 
    1625                 1630                 1635             


His Ile  Asn Arg His Asn Asn  Phe Arg Ser Phe Phe  Gly Ser Leu 
    1640                 1645                 1650             


Met Leu  Leu Phe Arg Ser Ala  Thr Gly Glu Ala Trp  Gln Glu Ile 
    1655                 1660                 1665             


Met Leu  Ser Cys Leu Gly Glu  Lys Gly Cys Glu Pro  Asp Thr Thr 
    1670                 1675                 1680             


Ala Pro  Ser Gly Gln Asn Glu  Asn Glu Arg Cys Gly  Thr Asp Leu 
    1685                 1690                 1695             


Ala Tyr  Val Tyr Phe Val Ser  Phe Ile Phe Phe Cys  Ser Phe Leu 
    1700                 1705                 1710             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1715                 1720                 1725             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1730                 1735                 1740             


Phe Val  Arg Val Trp Ala Glu  Tyr Asp Arg Ala Ala  Cys Gly Arg 
    1745                 1750                 1755             


Ile His  Tyr Thr Glu Met Tyr  Glu Met Leu Thr Leu  Met Ser Pro 
    1760                 1765                 1770             


Pro Leu  Gly Leu Gly Lys Arg  Cys Pro Ser Lys Val  Ala Tyr Lys 
    1775                 1780                 1785             


Arg Leu  Val Leu Met Asn Met  Pro Val Ala Glu Asp  Met Thr Val 
    1790                 1795                 1800             


His Phe  Thr Ser Thr Leu Met  Ala Leu Ile Arg Thr  Ala Leu Asp 
    1805                 1810                 1815             


Ile Lys  Ile Ala Lys Gly Gly  Ala Asp Arg Gln Gln  Leu Asp Ser 
    1820                 1825                 1830             


Glu Leu  Gln Lys Glu Thr Leu  Ala Ile Trp Pro His  Leu Ser Gln 
    1835                 1840                 1845             


Lys Met  Leu Asp Leu Leu Val  Pro Met Pro Lys Ala  Ser Asp Leu 
    1850                 1855                 1860             


Thr Val  Gly Lys Ile Tyr Ala  Ala Met Met Ile Met  Asp Tyr Tyr 
    1865                 1870                 1875             


Lys Gln  Ser Lys Val Lys Lys  Gln Arg Gln Gln Leu  Glu Glu Gln 
    1880                 1885                 1890             


Lys Asn  Ala Pro Met Phe Gln  Arg Met Glu Pro Ser  Ser Leu Pro 
    1895                 1900                 1905             


Gln Glu  Ile Ile Ala Asn Ala  Lys Ala Leu Pro Tyr  Leu Gln Gln 
    1910                 1915                 1920             


Asp Pro  Val Ser Gly Leu Ser  Gly Arg Ser Gly Tyr  Pro Ser Met 
    1925                 1930                 1935             


Ser Pro  Leu Ser Pro Gln Asp  Ile Phe Gln Leu Ala  Cys Met Asp 
    1940                 1945                 1950             


Pro Ala  Asp Asp Gly Gln Phe  Gln Glu Arg Gln Ser  Leu Val Val 
    1955                 1960                 1965             


Thr Asp  Pro Ser Ser Met Arg  Arg Ser Phe Ser Thr  Ile Arg Asp 
    1970                 1975                 1980             


Lys Arg  Ser Asn Ser Ser Trp  Leu Glu Glu Phe Ser  Met Glu Arg 
    1985                 1990                 1995             


Ser Ser  Glu Asn Thr Tyr Lys  Ser Arg Arg Arg Ser  Tyr His Ser 
    2000                 2005                 2010             


Ser Leu  Arg Leu Ser Ala His  Arg Leu Asn Ser Asp  Ser Gly His 
    2015                 2020                 2025             


Lys Ser  Asp Thr His Arg Ser  Gly Gly Arg Glu Arg  Gly Arg Ser 
    2030                 2035                 2040             


Lys Glu  Arg Lys His Leu Leu  Ser Pro Asp Val Ser  Arg Cys Asn 
    2045                 2050                 2055             


Ser Glu  Glu Arg Gly Thr Gln  Ala Asp Trp Glu Ser  Pro Glu Arg 
    2060                 2065                 2070             


Arg Gln  Ser Arg Ser Pro Ser  Glu Gly Arg Ser Gln  Thr Pro Asn 
    2075                 2080                 2085             


Arg Gln  Gly Thr Gly Ser Leu  Ser Glu Ser Ser Ile  Pro Ser Val 
    2090                 2095                 2100             


Ser Asp  Thr Ser Thr Pro Arg  Arg Ser Arg Arg Gln  Leu Pro Pro 
    2105                 2110                 2115             


Val Pro  Pro Lys Pro Arg Pro  Leu Leu Ser Tyr Ser  Ser Leu Ile 
    2120                 2125                 2130             


Arg His  Ala Gly Ser Ile Ser  Pro Pro Ala Asp Gly  Ser Glu Glu 
    2135                 2140                 2145             


Gly Ser  Pro Leu Thr Ser Gln  Ala Leu Glu Ser Asn  Asn Ala Cys 
    2150                 2155                 2160             


Leu Thr  Glu Ser Ser Asn Ser  Pro His Pro Gln Gln  Ser Gln His 
    2165                 2170                 2175             


Ala Ser  Pro Gln Arg Tyr Ile  Ser Glu Pro Tyr Leu  Ala Leu His 
    2180                 2185                 2190             


Glu Asp  Ser His Ala Ser Asp  Cys Gly Glu Glu Glu  Thr Leu Thr 
    2195                 2200                 2205             


Phe Glu  Ala Ala Val Ala Thr  Ser Leu Gly Arg Ser  Asn Thr Ile 
    2210                 2215                 2220             


Gly Ser  Ala Pro Pro Leu Arg  His Ser Trp Gln Met  Pro Asn Gly 
    2225                 2230                 2235             


His Tyr  Arg Arg Arg Arg Arg  Gly Gly Pro Gly Pro  Gly Met Met 
    2240                 2245                 2250             


Cys Gly  Ala Val Asn Asn Leu  Leu Ser Asp Thr Glu  Glu Asp Asp 
    2255                 2260                 2265             


Lys Cys  
    2270 


<210>  1451
<211>  2296
<212>  DNA
<213>  Homosapiens

<400>  1451
gatacatagg aaaccaaata acctagagaa aacaataccc atgaatgatt agcaaatttc     60

ttacatataa aggaaatgat ttaacttcaa gagactagaa taaatgaaaa catattcaaa    120

attgaaaacg ttaatggaag catgaaatca gctctgtgct gaatgcctca gggaaggaat    180

gtggcagaga acagaaaaca aaaatggtgt ttcgctctgc tacccaggct gaagtgcagt    240

ggtgtcatta tttctcactg cagcctcaaa cttctggcct ccagcgatcc tcctacctca    300

gtctccagac tgtcacttta gcagtactac tcttcggata tgcaatcaac tgtttggaaa    360

gaagagataa aagtcaaatt tttactatac taaaacataa gtctcaaaag atggagtgga    420

catactttac cctattcctc tcattaagta cagatcaaaa cctcagacat tatatgtaaa    480

agaaacataa gaagactctg aaagtggaga caagactggc tagggaccgt gggaccaaag    540

aatgacagca gtgtgtttcc tgagtttccc ttttatctca tatatcctgg attgggtgct    600

aaagaatcca gcaacccaga aatatcatcg gctgcagcta agagattttt ctcatgaaaa    660

gcctgctctc tctaaccaaa agaggacgaa aagggcgcct agcaagacag aaaactttta    720

gataataaca gcacaactcc agtcaaacat taatggaaat gcataacgca gtctccctcc    780

caaccccatc agcaaaggct agacgggagc ttggactcca ccctcattag atggaaacat    840

ggtacccaaa ttcccccaca tgataatatc agagaaggtg gagtaagaaa ccaagacctt    900

cattcctgtc ccaaggtaac tcctgtcaca ccttcgtagt gtcagtggag accatgcagg    960

caatcaatct acatgctgac ctggctgtta caagacaccc agttccctcc ttgccatgtt   1020

agtgtctgta ttagtcaggg ttctctagag gcacagaacg aataggatga atatataaaa   1080

gagagtttat taaggagtat taactcacat gatcacaagg ttccacaata ggccatctgc   1140

aagcaaagag gccagtctga gtcccaaagc tgaagaactt ggattctgat gtttgaggac   1200

aggaagcatt caacacagga gaaagatgta ggctgggagg ctaagccagt ctagtctctc   1260

cacgttcttc tgcccacttt ctattctggc cgcactggca gctgattaga tggcacccac   1320

ccagattgac ggtgggtctg cctctcccag tacactgcat caaatactaa tctcctttgg   1380

cagcaccctc acagacacac ccaggaacaa tactctgcat ccttcaatcc aatcaagttg   1440

acagtattaa ccatcacagt gtccaaagag aatgaatagg aaaaataaag gacatttatg   1500

acctcaagca ataatgaaga ctgccttgtc cttctgccta gtatcagtag aggtcatgtg   1560

gtacaaagta acaaggtact tctcctcctc ccagatagga tgatgccatc atagacctag   1620

tgagagccta aactcccatc cctgccgatc agtaacaaag tacaacttcc cctttgtgta   1680

tcagtgaagg ccacacttac ctggcagtaa tgaggtagca cttctgccag tgtggtatta   1740

gaggaggcct gctgaaacag aagatttaaa taagatctgg attctcatag cctaatacgc   1800

aatatgtcca gaatacagta gaaatttact tatcatacca agaaccagga caatcaagtt   1860

gaatgagaaa agacaatcac tgctcaactg aaacgaatct cagggatatg cgaacctgta   1920

gcaaagaatc aaacacctgt gtcattggag tcccatgaga agataaagaa ggtgagacta   1980

aaacagtact taaaacaatg tctgcaaatt taccaatttt ggcaaaaggt acaaattaca   2040

gatataagaa gcttagtgta agcataatag aacttgcggc ccatttcttt gctgtcaaac   2100

ttttcattat ctcctcattc atgcaaagaa ggaggaggtg aagaagaaaa agaaaaagaa   2160

ggagagcaca gaagtaggag gaggaaaagg agatgaagaa taagaagcag caacagttta   2220

gtgtacctta aacaggatga acccaacaaa ttccatgcca agacgcatca tatcatacct   2280

atgaaaacta aagcat                                                   2296


<210>  1452
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  1452

Met Val Phe Arg Ser Ala Thr Gln Ala Glu Val Gln Trp Cys His Tyr 
1               5                   10                  15      


Phe Ser Leu Gln Pro Gln Thr Ser Gly Leu Gln Arg Ser Ser Tyr Leu 
            20                  25                  30          


Ser Leu Gln Thr Val Thr Leu Ala Val Leu Leu Phe Gly Tyr Ala Ile 
        35                  40                  45              


Asn Cys Leu Glu Arg Arg Asp Lys Ser Gln Ile Phe Thr Ile Leu Lys 
    50                  55                  60                  


His Lys Ser Gln Lys Met Glu Trp Thr Tyr Phe Thr Leu Phe Leu Ser 
65                  70                  75                  80  


Leu Ser Thr Asp Gln Asn Leu Arg His Tyr Met 
                85                  90      


<210>  1453
<211>  885
<212>  DNA
<213>  Homosapiens

<400>  1453
aacctcatag gtggtttggg atgtcttttg gctgtgctta aaaatttcca acagatttgc     60

tacacatctt aggataaata tgtttcctgt gaattgtgat gatttcttac agtacatttg    120

caagcatgtg tatgcatctg caggaaacat agcctggctc tgtgaaggaa tactgctgtg    180

accgcaaaac tgtttctgta gaattttctc cggtgtggtc atcctgcctt cagaggtttc    240

tccaggacgt cacctgtatg aggtacacag tgtgatgaca cactctgtgc ttttcctact    300

tgtgtccacg gctcaagcct ggaagaagcc ttaggacgtg ggggaaatgt ctaacgtgga    360

gtccacctgc tgagcaggac cgggtgtgaa ggaagaagct ttgttctgat tcctcatggc    420

ccagccaccc ctcgcctgag ctgagcctgg ccacagggcc cgcctgcagg aagggctggc    480

ccatggcttc acactgggct caggctgcgc taagagcccc gggtgaggac ctccaagccc    540

aggaagcctc agttggccaa agtgctagat gcgtgtggtc tgctttcatc cccgcttccc    600

tcagagcttg cattttccaa attcaagaga ggctccacct tcaagaagac cggcctgtcc    660

ctgttattta tgtgtccccc taccatatct ccctttgttc tgcagagcgg ccatacctgc    720

cagcagcctg ctctcccggc catgctgcgg ttcacaaaag tccagcattt ggctagcttc    780

ctgggggaat gaatctttca gagccaaact aatgctatgc atgcagctta tgattttttt    840

ttttttgtct tcaacaaagt gaatacttac tttttttttg ctctt                    885


<210>  1454
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  1454

Met Ala Ser His Trp Ala Gln Ala Ala Leu Arg Ala Pro Gly Glu Asp 
1               5                   10                  15      


Leu Gln Ala Gln Glu Ala Ser Val Gly Gln Ser Ala Arg Cys Val Trp 
            20                  25                  30          


Ser Ala Phe Ile Pro Ala Ser Leu Arg Ala Cys Ile Phe Gln Ile Gln 
        35                  40                  45              


Glu Arg Leu His Leu Gln Glu Asp Arg Pro Val Pro Val Ile Tyr Val 
    50                  55                  60                  


Ser Pro Tyr His Ile Ser Leu Cys Ser Ala Glu Arg Pro Tyr Leu Pro 
65                  70                  75                  80  


Ala Ala Cys Ser Pro Gly His Ala Ala Val His Lys Ser Pro Ala Phe 
                85                  90                  95      


Gly 
    


<210>  1455
<211>  405
<212>  DNA
<213>  Homosapiens

<400>  1455
atggtcggcg gatatgaaaa aaagtccgtg gtcacgtgca aattcccgac tccagtgctg     60

gcgtgtgctc ggcctttctg tgttcctggc ccgcggccgt cgggtgtgag ctgcgccgac    120

cgctctgagg gttcgtggcc caccgctcct tcgcggtccc tgccgccacc gtccacgctc    180

agcgttgtag agaagatggt gggtcggaac agcgccatcg ccgccggtgt atgcggggcc    240

cttttcattg ggtactgcat ctacttcgac cgccagaagc ttgccaagga gagagctggg    300

ctttccaagt tacctgacct taaagatgct gaagctgttc agaagttctt ccttgaagaa    360

atacagcttg gtgaagagtt actagctcaa ggtaatagtc attga                    405


<210>  1456
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  1456

Met Val Gly Gly Tyr Glu Lys Lys Ser Val Val Thr Cys Lys Phe Pro 
1               5                   10                  15      


Thr Pro Val Leu Ala Cys Ala Arg Pro Phe Cys Val Pro Gly Pro Arg 
            20                  25                  30          


Pro Ser Gly Val Ser Cys Ala Asp Arg Ser Glu Gly Ser Trp Pro Thr 
        35                  40                  45              


Ala Pro Ser Arg Ser Leu Pro Pro Pro Ser Thr Leu Ser Val Val Glu 
    50                  55                  60                  


Lys Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala 
65                  70                  75                  80  


Leu Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Gln Lys Leu Ala Lys 
                85                  90                  95      


Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu Ala 
            100                 105                 110         


Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu Leu 
        115                 120                 125             


Ala Gln Gly Asn Ser His 
    130                 


<210>  1457
<211>  1431
<212>  DNA
<213>  Homosapiens

<400>  1457
agctgcagtc tgggagtctt tggagtaaga atggccttgg aagggatgag caaacggaag     60

agaaagagaa gtgtccagga gggagagaat cctgacgacg gcgttcgcgg gagtccgccg    120

gaagactaca ggcttggaca ggtcgccagt agcttatttc gcggcgaaca ccattccaga    180

ggtggcaccg gtcggctggc gtccctcttc agttctctgg agccccagat tcaacccgtg    240

tacgtgcctg tgcctaaaca aaccatcaaa aaaacgaaac ggaatgagga ggaagaaagt    300

acatcccaga ttgaaagacc actttcgcaa gaacctgcca aaaaagtgaa agcgaagaag    360

aaacacacta acgcagaaaa aaagttggca gacagggaaa gcgctctagc gagtgctgat    420

ttagaagaag aaattcacca gaaacaaggg cagaaaagga aaaattctca acctggtgtt    480

aaagtagcag atagaaaaat acttgatgac acagaagaca cagttgtcag tcaaagaaag    540

aaaattcaaa tcaaccaaga agaagagaga ttaaagaatg agagaactgt gtttgttggg    600

aatttgcctg ttacatgtaa taagaagaag ctgaagtcgt tttttaaaga gtatggacaa    660

atagaatctg tacgatttcg ttctctgatt ccagcagagg gaacgctatc caaaaagttg    720

gcagcaataa aacgtaaaat tcatcctgat cagaaaaata ttaatgccta tgttgtgttt    780

aaggaggaga gtgctgccac gcaagcattg aaaagaaatg gggcccagat tgcagatgga    840

tttcgtatta gagttgatct cgcatctgag acctcatcta gagacaagag atcggttttt    900

gtggggaatc tcccttataa agttgaagaa tctgccattg agaagcactt tctggactgt    960

ggaagtatca tggccgtgag gattgtgaga gacaaaatga caggcatcgg caaagggttt   1020

ggctatgtgc tctttgagaa tacagattct gttcatcttg ctctgaaatt aaataattct   1080

gaactcatgg ggagaaaact cagagtcatg cgttctgtta ataaagaaaa atttaaacaa   1140

caaaattcaa atccacgatt gaagaatgtc agtaaaccta agcagggact taattttact   1200

tccaaaactg cagaaggaca tcctaaaagc ttatttattg gagaaaaagc tgttctcctt   1260

aaaacgaaga agaaaggaca gaagaaaagt ggacgcccta agaaacagag aaaacagaaa   1320

taacaaccag gaactgcttt ttcttttcct gctgagtact gctaataaaa gtgctattat   1380

ctgctgatag catcgtctgc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            1431


<210>  1458
<211>  425
<212>  PRT
<213>  Homosapiens

<400>  1458

Met Ser Lys Arg Lys Arg Lys Arg Ser Val Gln Glu Gly Glu Asn Pro 
1               5                   10                  15      


Asp Asp Gly Val Arg Gly Ser Pro Pro Glu Asp Tyr Arg Leu Gly Gln 
            20                  25                  30          


Val Ala Ser Ser Leu Phe Arg Gly Glu His His Ser Arg Gly Gly Thr 
        35                  40                  45              


Gly Arg Leu Ala Ser Leu Phe Ser Ser Leu Glu Pro Gln Ile Gln Pro 
    50                  55                  60                  


Val Tyr Val Pro Val Pro Lys Gln Thr Ile Lys Lys Thr Lys Arg Asn 
65                  70                  75                  80  


Glu Glu Glu Glu Ser Thr Ser Gln Ile Glu Arg Pro Leu Ser Gln Glu 
                85                  90                  95      


Pro Ala Lys Lys Val Lys Ala Lys Lys Lys His Thr Asn Ala Glu Lys 
            100                 105                 110         


Lys Leu Ala Asp Arg Glu Ser Ala Leu Ala Ser Ala Asp Leu Glu Glu 
        115                 120                 125             


Glu Ile His Gln Lys Gln Gly Gln Lys Arg Lys Asn Ser Gln Pro Gly 
    130                 135                 140                 


Val Lys Val Ala Asp Arg Lys Ile Leu Asp Asp Thr Glu Asp Thr Val 
145                 150                 155                 160 


Val Ser Gln Arg Lys Lys Ile Gln Ile Asn Gln Glu Glu Glu Arg Leu 
                165                 170                 175     


Lys Asn Glu Arg Thr Val Phe Val Gly Asn Leu Pro Val Thr Cys Asn 
            180                 185                 190         


Lys Lys Lys Leu Lys Ser Phe Phe Lys Glu Tyr Gly Gln Ile Glu Ser 
        195                 200                 205             


Val Arg Phe Arg Ser Leu Ile Pro Ala Glu Gly Thr Leu Ser Lys Lys 
    210                 215                 220                 


Leu Ala Ala Ile Lys Arg Lys Ile His Pro Asp Gln Lys Asn Ile Asn 
225                 230                 235                 240 


Ala Tyr Val Val Phe Lys Glu Glu Ser Ala Ala Thr Gln Ala Leu Lys 
                245                 250                 255     


Arg Asn Gly Ala Gln Ile Ala Asp Gly Phe Arg Ile Arg Val Asp Leu 
            260                 265                 270         


Ala Ser Glu Thr Ser Ser Arg Asp Lys Arg Ser Val Phe Val Gly Asn 
        275                 280                 285             


Leu Pro Tyr Lys Val Glu Glu Ser Ala Ile Glu Lys His Phe Leu Asp 
    290                 295                 300                 


Cys Gly Ser Ile Met Ala Val Arg Ile Val Arg Asp Lys Met Thr Gly 
305                 310                 315                 320 


Ile Gly Lys Gly Phe Gly Tyr Val Leu Phe Glu Asn Thr Asp Ser Val 
                325                 330                 335     


His Leu Ala Leu Lys Leu Asn Asn Ser Glu Leu Met Gly Arg Lys Leu 
            340                 345                 350         


Arg Val Met Arg Ser Val Asn Lys Glu Lys Phe Lys Gln Gln Asn Ser 
        355                 360                 365             


Asn Pro Arg Leu Lys Asn Val Ser Lys Pro Lys Gln Gly Leu Asn Phe 
    370                 375                 380                 


Thr Ser Lys Thr Ala Glu Gly His Pro Lys Ser Leu Phe Ile Gly Glu 
385                 390                 395                 400 


Lys Ala Val Leu Leu Lys Thr Lys Lys Lys Gly Gln Lys Lys Ser Gly 
                405                 410                 415     


Arg Pro Lys Lys Gln Arg Lys Gln Lys 
            420                 425 


<210>  1459
<211>  3259
<212>  DNA
<213>  Homosapiens

<400>  1459
ggccgtcggg tgtgagctgc gccgaccgct ctgagggttc gtggcccacc gctccttcgc     60

ggtccctgcc gccaccgtcc acgctcagcg ttgtagagaa gatggtgggt cggaacagcg    120

ccatcgccgc cggtgtatgc ggggcccttt tcattgggta ctgcatctac ttcgaccgca    180

aaagacgaag tgaccccaac ttcaagaaca ggcttcgaga acgaagaaag aaacagaagc    240

ttgccaagga gagagctggg ctttccaagt tacctgacct taaagatgct gaagctgttc    300

agaagttctt ccttgaagaa atacagcttg gtgaagagtt actagctcaa ggtgaatatg    360

agaagggcgt agaccatctg acaaatgcaa ttgctgtgtg tggacagcca cagcagttac    420

tgcaggtctt acagcaaact cttccaccac cagtgttcca gatgcttctg actaagctcc    480

caacaattag tcagagaatt gtaagtgctc agagcttggc tgaagatgat gtggaatgag    540

aaacaaatgt caacataata aaatctcagt taaaaatatt ttaaaaattc ttggtagttg    600

agcagctctg ggggaataag ggcaaatatg cttgttatga actacactga aatctaccaa    660

agttaatgtt tactttgtgt agatccattt gtctatttta tttatttttc ccagtgaaaa    720

gtgtattttg atagagaact tttcattcta taaatacact atgagttact aaaatatcat    780

ggattttgtt tattcctgaa acatagttac atagttaaac tgtacatatg acatggctta    840

tgttaaaaat acccagtgct cagttttgaa agataggcaa aaaaaaaaaa agtataggag    900

aaactgaaga atgtacactt ttttagaggg cacattttgc tgtaaatctg gaaatttgat    960

agacttgact gtgtttgtga aaactgagca ttaaaggttt tgattgatcc tttctttcca   1020

tttaatctct gagacgtaaa tatgtgaggt gtgctgctgt gctgggttaa cagcttcctt   1080

ccctttctgt gtagcagtct tgaaatgttc tgtttaaatc agtaggctta atgtgttctg   1140

ggtatttatc tccttgtatt ttaaatatat gtagttgcaa atagcaccag gaattagatt   1200

tctgtacacc cctaatctag ccttgtgagc ttcgctagtt aatgtgtgct cactttccct   1260

ccatttgtta cgtgagagaa tgcgtctgct gatcactgaa gtgtcccttt tagcttctga   1320

ttcattgggt tctgttgggc atctttaaat ccaccttaac ctgaggaatg tatgtgggca   1380

accaggccct gcattttttt atattctgaa ttttgcatgc ttgcctgact tagtatttct   1440

gaattgatgt tttttttaat ggtataacta tcttgatttt cactgaaatt atatggttct   1500

gtcactactc tgtaaattaa tccgaaactt ttaaggtaac tgggatgatc tgcttgtaaa   1560

aatgcttgtt gccttttgct ttatcttcag tgtacctcct taatcctgct tcaacttgat   1620

tatcttgtga aacgatgaga gtaagttgca accttgtgac tgaaaacttg aaaagagtgg   1680

agcaggtggg acctcttatt ctcaaatagt gacatattct ccgtagtcac agtttcagaa   1740

ctgagtaagg atccttggta cttggtggca tctgttgaac tgaggagcat ttctcattgt   1800

aaagattgcc tttgttctgt ctaaaagtct ggagaaatcc caaagacttt tcctatgtac   1860

taggcatttt attttgattg acttacaaac tcttcttaat cattatcaat ctcggttttt   1920

ttgtggtgca gtggaaggag aaataggtct agtttctgcc tctgattagc cgcacagcct   1980

tgaacaaatc acatttcatc tttgaactta cctctactgt tagactaggc gactcacatt   2040

tgaggacttt tctcgggtat cttgagggtt tgtgatcctg aacccttaaa cagtgctttt   2100

ttgttacaca ggagggcttt tttgggggga tgaccagtac agacatgcca gttagtttta   2160

ctagtgggat cccaaatcca aagcagtgta gtggtgattg gtcagtgact aaccaggcag   2220

ctaagaagtc ttaggcagca gcccagacat gtatagaggg gcagttagag ggagaacagg   2280

ggtgggaaag ggagcaaggg gcagatagct cagcaaggaa agaatgggct cagaaaaagg   2340

agggctggct ggaggagtga ggggcagctt aagtttgggg agggtagaaa cgccgtttcc   2400

ttgggaactg gagtgcagta tgagctgggt gtcacttggc tctgaacata ctggctttgc   2460

tgtaatgctt gaaaaggcgt tggtatcttc attttacagt tcattaaccc aagtacgttt   2520

tcttatttaa atgacaactt tggtgcttta aaatgaggta ccacttttta aagctagctg   2580

tgtcgagtta aagaaaaaat cagcagtttt ttctcccaga aatgtaattg ccaaacactt   2640

ttcatcccca tcttaagttt tacaaggtga tgtaatcagc ttgttgtagt gatgctggcc   2700

aaatggtgct cagcaggtga gaacaaaaaa accccagatt tcagtgaact aatacacagc   2760

ttgagcgttt ccatgtgcta atgttgcaca cttactaaaa aactttggaa atggaaaata   2820

atgtattagt gcaacagttg atgtgcttct ttgggcaaag atatagtttt gttccacaat   2880

ttgtacttaa aagcgaaaga acattgaaaa catagactta ctggctgtag caatgctggc   2940

ctgttaactg ataactagaa cttaggttca cgtttatgta aagtgtgtaa aacctagtag   3000

agcttgcata gtcggcactc agtaaatgtt tggttccttt tgccccttgg taagtttatt   3060

ttaccatcct cccacctgcc attctgactt tattaaatca acatgtggac cagagtgtta   3120

atgagatgtt attgcagaag agattgagaa aattggtata tcatgcagat aacatacaaa   3180

atctttttgt aacgtaaaaa atgcagtttt attattgctt gtgcctcaac tgtttaagtg   3240

aatattaaag ggcttggag                                                3259


<210>  1460
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  1460

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  1461
<211>  6065
<212>  DNA
<213>  Homosapiens

<400>  1461
agcgatgttt gcccgtcagt cgagtccgga gtgaggagct cggtcgccga agcggaggga     60

gactcttgag cttcatcttg ccgccgccac ggccaccgcc tggacctttg cccggaggga    120

gctgcagagg gtccatcgcc gccgtcctct ggagggcagc gcgattgggg gcccggacct    180

ccagtccggg ggggattttt cgtcgtcccc ctccccccaa ccagggagcc cgagcggccg    240

ccaaacaaag gtaccagtcg ccgccgcggg aggaggagga gccggagcct ctgcctcagc    300

agccgctgga cccgccgccc ttcttcccca tctctccccc gggcctgctg gttttggggg    360

ggagaaggag agaggggact ctggacgtgc cagggtcaga tctcgcctcc gaggaaggtg    420

cagctgaacc tggtgtttta gaggatacct tggtcccaga gtcatcatga aggcccttga    480

tgagcctccc tatttgacag tgggcactga tgtgagtgct aaatacagag gagccttttg    540

tgaagccaag atcaagacag caaaaagact tgtcaaagtc aaggtgacat ttagacatga    600

ttcttcaaca gtggaagttc aggatgacca cataaagggc ccactaaagg taggagctat    660

tgtggaagtg aagaatcttg atggtgcata tcaggaagct gttatcaata aactaacaga    720

tgcgagttgg tacactgtag tttttgatga cggagatgag aagacactga gacgatcttc    780

actgtgcctg aaaggagaga ggcattttgc tgaaagtgaa acattagacc agctcccact    840

caccaaccct gagcattttg gcactccagt cataggaaag aaaacaaata gaggaagaag    900

atctaatcat ataccagagg aagagtcttc atcatcctcc agtgatgaag atgaggatga    960

taggaaacag attgatgagc tactaggcaa agttgtatgt gtagattaca ttagtttgga   1020

taaaaagaaa gcactgtggt ttcctgcatt ggtggtttgt cctgattgta gtgatgagat   1080

tgctgtaaaa aaggacaata ttcttgttcg atctttcaaa gatggaaaat ttacttcagt   1140

tccaagaaaa gatgtccatg aaattactag tgacactgca ccaaagcctg atgctgtttt   1200

aaagcaagcc tttgaacagg cacttgaatt tcacaaaagt agaactattc ctgctaactg   1260

gaagactgaa ttgaaagaag atagctctag cagtgaagca gaggaagaag aggaggagga   1320

agatgatgaa aaagaaaagg aggataatag cagtgaagaa gaagaagaaa tagaaccatt   1380

tccagaagaa agggagaact ttcttcagca attgtacaaa tttatggaag atagaggtac   1440

acctattaac aaacgacctg tacttggata tcgaaatttg aatctcttta agttattcag   1500

acttgtacac aaacttggag gatttgataa tattgaaagt ggagctgttt ggaaacaagt   1560

ctaccaagat cttggaatcc ctgtcttaaa ttcagctgca ggatacaatg ttaaatgtgc   1620

ttataaaaaa tacttatatg gttttgagga gtactgtaga tcagccaaca ttgaatttca   1680

gatggcattg ccagagaaag ttgttaacaa gcaatgtaag gagtgtgaaa atgtaaaaga   1740

aataaaagtt aaggaggaaa atgaaacaga gatcaaagaa ataaagatgg aggaggagag   1800

gaatataata ccaagagaag aaaagcctat tgaggatgaa attgaaagaa aagaaaatat   1860

taagccctct ctgggaagta aaaagaattt attagaatct atacctacac attctgatca   1920

ggaaaaagaa gttaacatta aaaaaccaga agacaatgaa aatctggatg acaaagatga   1980

tgacacaact agggtagatg aatccctcaa cataaaggta gaagctgagg aagaaaaagc   2040

aaaatctgga gatgaaacga ataaagaaga agatgaagat gatgaagaag cagaagagga   2100

ggaggaggag gaagaagaag aagaggatga agatgatgat gacaacaatg aggaagagga   2160

gtttgagtgc tatccaccag gcatgaaagt ccaagtgcgg tatggacgag ggaaaaatca   2220

aaaaatgtat gaagctagta ttaaagattc tgatgtcgaa ggtggagagg tcctttactt   2280

ggtgcattac tgcggatgga atgtgagata cgatgaatgg attaaagcag ataaaatagt   2340

aagacctgct gataaaaatg tgccaaagat aaaacatcgg aagaaaataa agaataaatt   2400

agacaaagaa aaagacaaag atgaaaaata ctctccaaaa aactgtaaac ttcggcgctt   2460

gtccaaacca ccatttcaga caaatccatc tcctgaaatg gtatccaaac tggatctcac   2520

tgatgccaaa aactctgata ctgctcatat taagtccata gaaattactt cgatccttaa   2580

tggacttcaa gcttctgaaa gttctgctga agacagtgag caggaagatg agagaggtgc   2640

tcaagacatg gataataatg gcaaagagga atctaagatt gatcatttga ccaacaacag   2700

aaatgatctt atttcaaagg aggaacagaa cagttcatct ttgctagaag aaaacaaagt   2760

tcatgcagat ttggtaatat ccaaaccagt gtcaaaatct ccagaaagat taaggaaaga   2820

tatagaagta ttatccgaag atactgatta tgaagaagat gaagtcacaa aaaagagaaa   2880

ggatgtcaag aaggacacaa cagataaatc ttcaaaacca caaataaaac gtggtaaaag   2940

aaggtattgc aatacagaag agtgtctaaa aactggatca cctggcaaaa aggaagagaa   3000

ggccaagaac aaagaatcac tttgcatgga aaacagtagc aacagctctt cagatgaaga   3060

tgaagaagaa acaaaagcaa agatgacacc aactaagaaa tacaatggtt tggaggaaaa   3120

aagaaaatct ctacggacaa ctggtttcta ttcaggattt tcagaagtgg cagaaaaaag   3180

gattaaactt ttaaataact ctgatgaaag acttcaaaac agcagggcca aagatcgaaa   3240

agatgtctgg tcaagtattc agggacagtg gcctaaaaaa acgctgaaag agcttttttc   3300

agactctgat actgaggctg cagcttcccc accgcatcct gccccagagg agggggtggc   3360

agaggagtca ctgcagactg tggctgaaga ggagagttgt tcacccagtg tagaactaga   3420

aaaaccacct ccagtcaatg tcgatagtaa acccattgaa gaaaaaacag tagaggtcaa   3480

tgacagaaaa gcagaatttc caagtagtgg cagtaattca gtgctaaata cccctcctac   3540

tacacctgaa tcgccttcat cagtcactgt aacagaaggc agccggcagc agtcttctgt   3600

aacagtatca gaaccactgg ctccaaacca agaagaggtt cgaagtatca agagtgaaac   3660

tgatagcaca attgaggtgg atagtgttgc tggggagctc caagacctcc agtctgaagg   3720

gaatagctcg ccagcaggtt ttgatgccag tgtgagctca agcagtagta atcagccaga   3780

accagaacat cctgaaaaag cctgtacagg tcagaaaaga gtgaaagatg ctcagggagg   3840

aggaagttca tcaaaaaagc agaaaagaag ccataaagca acagtggtaa acaacaaaaa   3900

gaagggaaaa ggcacaaata gtagtgatag tgaagaactt tcagctggtg aaagtataac   3960

taagagtcag ccagtcaaat cagtttccac tggaatgaag tctcatagta ccaaatctcc   4020

cgcaaggacg cagtctccag gaaaatgtgg aaagaatggt gataaggatc ctgatctcaa   4080

ggaacccagt aatcgattac ccaaagttta caaatggagt tttcagatgt cggacctgga   4140

aaatatgaca agtgccgaac gcatcacaat tcttcaagaa aaacttcaag aaatcagaaa   4200

acattatctg tcattaaaat ctgaagtagc ttccattgat cggaggagaa agcgtttaaa   4260

gaagaaagag agagaaagtg ctgctacatc ctcatcctcc tcttcacctt catccagttc   4320

cataacagct gctgttatgt taactttagc tgaaccgtca atgtccagcg catcacaaaa   4380

tggaatgtca gttgagtgca ggtgacagca ggacttgcta aagcactttg cacttaatgg   4440

ctgttgaggg ccactttttt tttatactgc acagtggcac aaaaaaatat cagacaagca   4500

ctattttata tttaaaaatt gtttcttgac aagctgactt ggcacttaag tgcacttttt   4560

tatgaagaaa aagtacaatg aactgctttt cctcaagcaa taattgtttc caacttgtct   4620

gggaattgtg tgtctggtaa ctggaaggcc ttccactgtg gcaaatggag gcttttcact   4680

gcctgtagag acaatacagt aagcatagtt aaggggtggg tcagaacatg ttaagataac   4740

ttactgtata tgtattccct tgtattttgt taaagctgga acatttgata tttttccatt   4800

tatttatgaa aaaatatgaa cctattttca tttgtacaag gtaattgttt tttaaagcaa   4860

gtcaccttag ggtggcttta attgtataag tcaagcacat gtaataaatt caaaacctgc   4920

agttaacagg atattagaca tcaatcctgg taaccaaata ttaaagattc tctttaaaaa   4980

agactgaaca tgtttacagg tttgaattag gctaaaaggt cttgcagtgg cttttcatgg   5040

cccttcaaat tggaatggaa ctactgtact ttgccatttt tctataaatc agtatttttt   5100

tttaattttg atatacattg tgtgaaaaaa gaaaatggct aataaactgt attaaatctt   5160

aaacaatgta taaagattgt acttagccag ttcaaagtgt atatttattc ataatgaatt   5220

ataacagtta tatttttgtg ttttcttgta aatgtttctt ttcccttaaa tacagataat   5280

tcatttgtat tgcttatttt attatgagct acaacaaaag gacttcagga acaagtaatg   5340

tattagtatg gttcaagatt gttgatagga actgtctcaa aaggatggtg gttattttaa   5400

atataaatag ctaatggggg tggtaggcct ataaaattaa atgccttgta taaaatccaa   5460

aatgaatgca aaattgtttt cacttgtatt gactttatgt tgtatgattc caatctctgt   5520

tctgtttggc acttgtattt aattcttcac ctttgtaaga catttgtata ttgtggatgt   5580

gttcattcaa gctatttaat atctggcact gttaatacac agtactttat tgtacagact   5640

gttttactgt tttaattgta gttctgtgta ctttttttgg atggggctgg catgttttct   5700

ttgtttcctg gcaatacgac gtgggaattt caatgcgttt tgttgtagat gctaacgtgt   5760

cagaatcctt tacattcaac ttttctaaga aaagcatttt cagtcttgta gtgtgtgctt   5820

acagtaacta attttgttga aaatggtttc aagttattca aatttgtaca ggactgtaaa   5880

gatttgttga cagcaaaatg ttgaagaaaa aagcttatag aataaaagct ataaagtata   5940

tattaggatc tgcaaacaat gaagaattat gtaatatatt gtacaaatgt aagcaaaggc   6000

tctgaaataa aatgccatag tttgtgaatc cttaaaaaaa aaaaaaaaaa aaaaaaaaaa   6060

aaaaa                                                               6065


<210>  1462
<211>  1312
<212>  PRT
<213>  Homosapiens

<400>  1462

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu 
            820                 825                 830         


Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Thr Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Thr Pro 
    1010                 1015                 1020             


Pro Thr  Thr Pro Glu Ser Pro  Ser Ser Val Thr Val  Thr Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Thr Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Thr  Asp Ser Thr 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Thr Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Thr Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Thr  Asn Ser Ser Asp Ser  Glu Glu Leu 
    1145                 1150                 1155             


Ser Ala  Gly Glu Ser Ile Thr  Lys Ser Gln Pro Val  Lys Ser Val 
    1160                 1165                 1170             


Ser Thr  Gly Met Lys Ser His  Ser Thr Lys Ser Pro  Ala Arg Thr 
    1175                 1180                 1185             


Gln Ser  Pro Gly Lys Cys Gly  Lys Asn Gly Asp Lys  Asp Pro Asp 
    1190                 1195                 1200             


Leu Lys  Glu Pro Ser Asn Arg  Leu Pro Lys Val Tyr  Lys Trp Ser 
    1205                 1210                 1215             


Phe Gln  Met Ser Asp Leu Glu  Asn Met Thr Ser Ala  Glu Arg Ile 
    1220                 1225                 1230             


Thr Ile  Leu Gln Glu Lys Leu  Gln Glu Ile Arg Lys  His Tyr Leu 
    1235                 1240                 1245             


Ser Leu  Lys Ser Glu Val Ala  Ser Ile Asp Arg Arg  Arg Lys Arg 
    1250                 1255                 1260             


Leu Lys  Lys Lys Glu Arg Glu  Ser Ala Ala Thr Ser  Ser Ser Ser 
    1265                 1270                 1275             


Ser Ser  Pro Ser Ser Ser Ser  Ile Thr Ala Ala Val  Met Leu Thr 
    1280                 1285                 1290             


Leu Ala  Glu Pro Ser Met Ser  Ser Ala Ser Gln Asn  Gly Met Ser 
    1295                 1300                 1305             


Val Glu  Cys Arg 
    1310         


<210>  1463
<211>  5807
<212>  DNA
<213>  Homosapiens

<400>  1463
agcgatgttt gcccgtcagt cgagtccgga gtgaggagct cggtcgccga agcggaggga     60

gactcttgag cttcatcttg ccgccgccac ggccaccgcc tggacctttg cccggaggga    120

gctgcagagg gtccatcgcc gccgtcctct ggagggcagc gcgattgggg gcccggacct    180

ccagtccggg ggggattttt cgtcgtcccc ctccccccaa ccagggagcc cgagcggccg    240

ccaaacaaag gtaccagtcg ccgccgcggg aggaggagga gccggagcct ctgcctcagc    300

agccgctgga cccgccgccc ttcttcccca tctctccccc gggcctgctg gttttggggg    360

ggagaaggag agaggggact ctggacgtgc cagggtcaga tctcgcctcc gaggaaggtg    420

cagctgaacc tggtgtttta gaggatacct tggtcccaga gtcatcatga aggcccttga    480

tgagcctccc tatttgacag tgggcactga tgtgagtgct aaatacagag gagccttttg    540

tgaagccaag atcaagacag caaaaagact tgtcaaagtc aaggtgacat ttagacatga    600

ttcttcaaca gtggaagttc aggatgacca cataaagggc ccactaaagg taggagctat    660

tgtggaagtg aagaatcttg atggtgcata tcaggaagct gttatcaata aactaacaga    720

tgcgagttgg tacactgtag tttttgatga cggagatgag aagacactga gacgatcttc    780

actgtgcctg aaaggagaga ggcattttgc tgaaagtgaa acattagacc agctcccact    840

caccaaccct gagcattttg gcactccagt cataggaaag aaaacaaata gaggaagaag    900

atctaatcat ataccagagg aagagtcttc atcatcctcc agtgatgaag atgaggatga    960

taggaaacag attgatgagc tactaggcaa agttgtatgt gtagattaca ttagtttgga   1020

taaaaagaaa gcactgtggt ttcctgcatt ggtggtttgt cctgattgta gtgatgagat   1080

tgctgtaaaa aaggacaata ttcttgttcg atctttcaaa gatggaaaat ttacttcagt   1140

tccaagaaaa gatgtccatg aaattactag tgacactgca ccaaagcctg atgctgtttt   1200

aaagcaagcc tttgaacagg cacttgaatt tcacaaaagt agaactattc ctgctaactg   1260

gaagactgaa ttgaaagaag atagctctag cagtgaagca gaggaagaag aggaggagga   1320

agatgatgaa aaagaaaagg aggataatag cagtgaagaa gaagaagaaa tagaaccatt   1380

tccagaagaa agggagaact ttcttcagca attgtacaaa tttatggaag atagaggtac   1440

acctattaac aaacgacctg tacttggata tcgaaatttg aatctcttta agttattcag   1500

acttgtacac aaacttggag gatttgataa tattgaaagt ggagctgttt ggaaacaagt   1560

ctaccaagat cttggaatcc ctgtcttaaa ttcagctgca ggatacaatg ttaaatgtgc   1620

ttataaaaaa tacttatatg gttttgagga gtactgtaga tcagccaaca ttgaatttca   1680

gatggcattg ccagagaaag ttgttaacaa gcaatgtaag gagtgtgaaa atgtaaaaga   1740

aataaaagtt aaggaggaaa atgaaacaga gatcaaagaa ataaagatgg aggaggagag   1800

gaatataata ccaagagaag aaaagcctat tgaggatgaa attgaaagaa aagaaaatat   1860

taagccctct ctgggaagta aaaagaattt attagaatct atacctacac attctgatca   1920

ggaaaaagaa gttaacatta aaaaaccaga agacaatgaa aatctggatg acaaagatga   1980

tgacacaact agggtagatg aatccctcaa cataaaggta gaagctgagg aagaaaaagc   2040

aaaatctgga tacgatgaat ggattaaagc agataaaata gtaagacctg ctgataaaaa   2100

tgtgccaaag ataaaacatc ggaagaaaat aaagaataaa ttagacaaag aaaaagacaa   2160

agatgaaaaa tactctccaa aaaactgtaa acttcggcgc ttgtccaaac caccatttca   2220

gacaaatcca tctcctgaaa tggtatccaa actggatctc actgatgcca aaaactctga   2280

tactgctcat attaagtcca tagaaattac ttcgatcctt aatggacttc aagcttctga   2340

aagttctgct gaagacagtg agcaggaaga tgagagaggt gctcaagaca tggataataa   2400

tggcaaagag gaatctaaga ttgatcattt gaccaacaac agaaatgatc ttatttcaaa   2460

ggaggaacag aacagttcat ctttgctaga agaaaacaaa gttcatgcag atttggtaat   2520

atccaaacca gtgtcaaaat ctccagaaag attaaggaaa gatatagaag tattatccga   2580

agatactgat tatgaagaag atgaagtcac aaaaaagaga aaggatgtca agaaggacac   2640

aacagataaa tcttcaaaac cacaaataaa acgtggtaaa agaaggtatt gcaatacaga   2700

agagtgtcta aaaactggat cacctggcaa aaaggaagag aaggccaaga acaaagaatc   2760

actttgcatg gaaaacagta gcaacagctc ttcagatgaa gatgaagaag aaacaaaagc   2820

aaagatgaca ccaactaaga aatacaatgg tttggaggaa aaaagaaaat ctctacggac   2880

aactggtttc tattcaggat tttcagaagt ggcagaaaaa aggattaaac ttttaaataa   2940

ctctgatgaa agacttcaaa acagcagggc caaagatcga aaagatgtct ggtcaagtat   3000

tcagggacag tggcctaaaa aaacgctgaa agagcttttt tcagactctg atactgaggc   3060

tgcagcttcc ccaccgcatc ctgccccaga ggagggggtg gcagaggagt cactgcagac   3120

tgtggctgaa gaggagagtt gttcacccag tgtagaacta gaaaaaccac ctccagtcaa   3180

tgtcgatagt aaacccattg aagaaaaaac agtagaggtc aatgacagaa aagcagaatt   3240

tccaagtagt ggcagtaatt cagtgctaaa tacccctcct actacacctg aatcgccttc   3300

atcagtcact gtaacagaag gcagccggca gcagtcttct gtaacagtat cagaaccact   3360

ggctccaaac caagaagagg ttcgaagtat caagagtgaa actgatagca caattgaggt   3420

ggatagtgtt gctggggagc tccaagacct ccagtctgaa gggaatagct cgccagcagg   3480

ttttgatgcc agtgtgagct caagcagtag taatcagcca gaaccagaac atcctgaaaa   3540

agcctgtaca ggtcagaaaa gagtgaaaga tgctcaggga ggaggaagtt catcaaaaaa   3600

gcagaaaaga agccataaag caacagtggt aaacaacaaa aagaagggaa aaggcacaaa   3660

tagtagtgat agtgaagaac tttcagctgg tgaaagtata actaagagtc agccagtcaa   3720

atcagtttcc actggaatga agtctcatag taccaaatct cccgcaagga cgcagtctcc   3780

aggaaaatgt ggaaagaatg gtgataagga tcctgatctc aaggaaccca gtaatcgatt   3840

acccaaagtt tacaaatgga gttttcagat gtcggacctg gaaaatatga caagtgccga   3900

acgcatcaca attcttcaag aaaaacttca agaaatcaga aaacattatc tgtcattaaa   3960

atctgaagta gcttccattg atcggaggag aaagcgttta aagaagaaag agagagaaag   4020

tgctgctaca tcctcatcct cctcttcacc ttcatccagt tccataacag ctgctgttat   4080

gttaacttta gctgaaccgt caatgtccag cgcatcacaa aatggaatgt cagttgagtg   4140

caggtgacag caggacttgc taaagcactt tgcacttaat ggctgttgag ggccactttt   4200

tttttatact gcacagtggc acaaaaaaat atcagacaag cactatttta tatttaaaaa   4260

ttgtttcttg acaagctgac ttggcactta agtgcacttt tttatgaaga aaaagtacaa   4320

tgaactgctt ttcctcaagc aataattgtt tccaacttgt ctgggaattg tgtgtctggt   4380

aactggaagg ccttccactg tggcaaatgg aggcttttca ctgcctgtag agacaataca   4440

gtaagcatag ttaaggggtg ggtcagaaca tgttaagata acttactgta tatgtattcc   4500

cttgtatttt gttaaagctg gaacatttga tatttttcca tttatttatg aaaaaatatg   4560

aacctatttt catttgtaca aggtaattgt tttttaaagc aagtcacctt agggtggctt   4620

taattgtata agtcaagcac atgtaataaa ttcaaaacct gcagttaaca ggatattaga   4680

catcaatcct ggtaaccaaa tattaaagat tctctttaaa aaagactgaa catgtttaca   4740

ggtttgaatt aggctaaaag gtcttgcagt ggcttttcat ggcccttcaa attggaatgg   4800

aactactgta ctttgccatt tttctataaa tcagtatttt tttttaattt tgatatacat   4860

tgtgtgaaaa aagaaaatgg ctaataaact gtattaaatc ttaaacaatg tataaagatt   4920

gtacttagcc agttcaaagt gtatatttat tcataatgaa ttataacagt tatatttttg   4980

tgttttcttg taaatgtttc ttttccctta aatacagata attcatttgt attgcttatt   5040

ttattatgag ctacaacaaa aggacttcag gaacaagtaa tgtattagta tggttcaaga   5100

ttgttgatag gaactgtctc aaaaggatgg tggttatttt aaatataaat agctaatggg   5160

ggtggtaggc ctataaaatt aaatgccttg tataaaatcc aaaatgaatg caaaattgtt   5220

ttcacttgta ttgactttat gttgtatgat tccaatctct gttctgtttg gcacttgtat   5280

ttaattcttc acctttgtaa gacatttgta tattgtggat gtgttcattc aagctattta   5340

atatctggca ctgttaatac acagtacttt attgtacaga ctgttttact gttttaattg   5400

tagttctgtg tacttttttt ggatggggct ggcatgtttt ctttgtttcc tggcaatacg   5460

acgtgggaat ttcaatgcgt tttgttgtag atgctaacgt gtcagaatcc tttacattca   5520

acttttctaa gaaaagcatt ttcagtcttg tagtgtgtgc ttacagtaac taattttgtt   5580

gaaaatggtt tcaagttatt caaatttgta caggactgta aagatttgtt gacagcaaaa   5640

tgttgaagaa aaaagcttat agaataaaag ctataaagta tatattagga tctgcaaaca   5700

atgaagaatt atgtaatata ttgtacaaat gtaagcaaag gctctgaaat aaaatgccat   5760

agtttgtgaa tccttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 5807


<210>  1464
<211>  1226
<212>  PRT
<213>  Homosapiens

<400>  1464

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys 
    530                 535                 540                 


Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp 
545                 550                 555                 560 


Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu 
                565                 570                 575     


Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu Met 
            580                 585                 590         


Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala His 
        595                 600                 605             


Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala Ser 
    610                 615                 620                 


Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln 
625                 630                 635                 640 


Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Thr 
                645                 650                 655     


Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser 
            660                 665                 670         


Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro 
        675                 680                 685             


Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser 
    690                 695                 700                 


Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys Asp 
705                 710                 715                 720 


Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg 
                725                 730                 735     


Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly Ser 
            740                 745                 750         


Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met 
        755                 760                 765             


Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr Lys 
    770                 775                 780                 


Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg 
785                 790                 795                 800 


Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala 
                805                 810                 815     


Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn 
            820                 825                 830         


Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln 
        835                 840                 845             


Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr Glu 
    850                 855                 860                 


Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu 
865                 870                 875                 880 


Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val 
                885                 890                 895     


Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu 
            900                 905                 910         


Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser 
        915                 920                 925             


Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser Pro 
    930                 935                 940                 


Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val Thr 
945                 950                 955                 960 


Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys 
                965                 970                 975     


Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu Leu 
            980                 985                 990         


Gln Asp Leu Gln Ser Glu Gly Asn  Ser Ser Pro Ala Gly  Phe Asp Ala 
        995                 1000                 1005             


Ser Val  Ser Ser Ser Ser Ser  Asn Gln Pro Glu Pro  Glu His Pro 
    1010                 1015                 1020             


Glu Lys  Ala Cys Thr Gly Gln  Lys Arg Val Lys Asp  Ala Gln Gly 
    1025                 1030                 1035             


Gly Gly  Ser Ser Ser Lys Lys  Gln Lys Arg Ser His  Lys Ala Thr 
    1040                 1045                 1050             


Val Val  Asn Asn Lys Lys Lys  Gly Lys Gly Thr Asn  Ser Ser Asp 
    1055                 1060                 1065             


Ser Glu  Glu Leu Ser Ala Gly  Glu Ser Ile Thr Lys  Ser Gln Pro 
    1070                 1075                 1080             


Val Lys  Ser Val Ser Thr Gly  Met Lys Ser His Ser  Thr Lys Ser 
    1085                 1090                 1095             


Pro Ala  Arg Thr Gln Ser Pro  Gly Lys Cys Gly Lys  Asn Gly Asp 
    1100                 1105                 1110             


Lys Asp  Pro Asp Leu Lys Glu  Pro Ser Asn Arg Leu  Pro Lys Val 
    1115                 1120                 1125             


Tyr Lys  Trp Ser Phe Gln Met  Ser Asp Leu Glu Asn  Met Thr Ser 
    1130                 1135                 1140             


Ala Glu  Arg Ile Thr Ile Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1145                 1150                 1155             


Lys His  Tyr Leu Ser Leu Lys  Ser Glu Val Ala Ser  Ile Asp Arg 
    1160                 1165                 1170             


Arg Arg  Lys Arg Leu Lys Lys  Lys Glu Arg Glu Ser  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Ser Ser Ser Ser Pro  Ser Ser Ser Ser Ile  Thr Ala Ala 
    1190                 1195                 1200             


Val Met  Leu Thr Leu Ala Glu  Pro Ser Met Ser Ser  Ala Ser Gln 
    1205                 1210                 1215             


Asn Gly  Met Ser Val Glu Cys  Arg 
    1220                 1225     


<210>  1465
<211>  3138
<212>  DNA
<213>  Homosapiens

<400>  1465
cccgtgttct gcgttgccgg ccgtgggtgc tctggccaca gtgagttagg ggcgtcggag     60

cgggtttctc caaccgcaat cggctccgct caaggggagg aggagagtcc cttctcggaa    120

ggcctaagga aacgtgtcgt ctggaatggg cttgggggcc acgcctgcac atctccgcga    180

gacagaggga taaagtgaag atggtgctgt tattgttacc tcgagtgcca catgcgacct    240

ctgagatatg tacacagtca ttcttactat cgcactcagc cattcttact acgctaaaga    300

agaaataatt attcgaggat atttgcctgg cccagaagaa acttatgtaa atttcatgaa    360

ctattatatc cgttttcctc ggagtgagag aaaactcttt ttagatatca tctgagaggt    420

agttaatttg gcaccatggg gatacaggga ttgctacaat ttatcaaaga agcttcagaa    480

cccatccatg tgaggaagta taaagggcag gtagtagctg tggatacata ttgctggctt    540

cacaaaggag ctattgcttg tgctgaaaaa ctagccaaag gtgaacctac tgataggtat    600

gtaggatttt gtatgaaatt tgtaaatatg ttactatctc atgggatcaa gcctattctc    660

gtatttgatg gatgtacttt accttctaaa aaggaagtag agagatctag aagagaaaga    720

cgacaagcca atcttcttaa gggaaagcaa cttcttcgtg aggggaaagt ctcggaagct    780

cgagagtgtt tcacccggtc tatcaatatc acacatgcca tggcccacaa agtaattaaa    840

gctgcccggt ctcagggggt agattgcctc gtggctccct atgaagctga tgcgcagttg    900

gcctatctta acaaagcggg aattgtgcaa gccataatta cagaggactc ggatctccta    960

gcttttggct gtaaaaaggt aattttaaag atggaccagt ttggaaatgg acttgaaatt   1020

gatcaagctc ggctaggaat gtgcagacag cttggggatg tattcacgga agagaagttt   1080

cgttacatgt gtattctttc aggttgtgac tacctgtcat cactgcgtgg gattggatta   1140

gcaaaggcat gcaaagtcct aagactagcc aataatccag atatagtaaa ggttatcaag   1200

aaaattggac attatctcaa gatgaatatc acggtaccag aggattacat caacgggttt   1260

attcgggcca acaatacctt cctctatcag ctagtttttg atcccatcaa aaggaaactt   1320

attcctctga acgcctatga agatgatgtt gatcctgaaa cactaagcta cgctgggcaa   1380

tatgttgatg attccatagc tcttcaaata gcacttggaa ataaagatat aaatactttt   1440

gaacagatcg atgactacaa tccagacact gctatgcctg cccattcaag aagtcatagt   1500

tgggatgaca aaacatgtca aaagtcagct aatgttagca gcatttggca taggaattac   1560

tctcccagac cagagtcggg tactgtttca gatgccccac aattgaagga aaatccaagt   1620

actgtgggag tggaacgagt gattagtact aaagggttaa atctcccaag gaaatcatcc   1680

attgtgaaaa gaccaagaag tgcagagctg tcagaagatg acctgttgag tcagtattct   1740

ctttcattta cgaagaagac caagaaaaat agctctgaag gcaataaatc attgagcttt   1800

tctgaagtgt ttgtgcctga cctggtaaat ggacctacta acaaaaagag tgtaagcact   1860

ccacctagga cgagaaataa atttgcaaca tttttacaaa ggaaaaatga agaaagtggt   1920

gcagttgtgg ttccagggac cagaagcagg tttttttgca gttcagattc tactgactgt   1980

gtatcaaaca aagtgagcat ccagcctctg gatgaaactg ctgtcacaga taaagagaac   2040

aatctgcatg aatcagagta tggagaccaa gaaggcaaga gactggttga cacagatgta   2100

gcacgtaatt caagtgatga cattccgaat aatcatattc caggtgatca tattccagac   2160

aaggcaacag tgtttacaga tgaagagtcc tactcttttg agagcagcaa atttacaagg   2220

accatttcac cacccacttt gggaacacta agaagttgtt ttagttggtc tggaggtctt   2280

ggagattttt caagaacgcc gagcccctct ccaagcacag cattgcagca gttccgaaga   2340

aagagcgatt cccccacctc tttgcctgag aataatatgt ctgatgtgtc gcagttaaag   2400

agcgaggagt ccagtgacga tgagtctcat cccttacgag aaggggcatg ttcttcacag   2460

tcccaggaaa gtggagaatt ctcactgcag agttcaaatg catcaaagct ttctcagtgc   2520

tctagtaagg actctgattc agaggaatct gattgcaata ttaagttact tgacagtcaa   2580

agtgaccaga cctccaagct atgtttatct catttctcaa aaaaagacac acctctaagg   2640

aacaaggttc ctgggctata taagtccagt tctgcagact ctctttctac aaccaagatc   2700

aaacctctag gacctgccag agccagtggg ctgagcaaga agccggcaag catccagaag   2760

agaaagcatc ataatgccga gaacaagccg gggttacaga tcaaactcaa tgagctctgg   2820

aaaaactttg gatttaaaaa attctgaaaa gcttcctcct tgtaagaaac ccctgtcccc   2880

agtcagagat aacatccaac taactccaga agcggaagag gatatattta acaaacctga   2940

atgtggccgt gttcaaagag caatattcca gtaaatgcag actgctgcaa agcttttgcc   3000

tgcaagagaa tctgatcaat ttgaagtccc tgtttgggaa tgaggcactt atcagcatga   3060

agaatttttt ctcattctgt gccattttaa aaatagaata cattttgtat attaacttta   3120

aaaaaaaaaa aaaaaaaa                                                 3138


<210>  1466
<211>  803
<212>  PRT
<213>  Homosapiens

<400>  1466

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Gly Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Cys Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Phe 
            


<210>  1467
<211>  3140
<212>  DNA
<213>  Homosapiens

<400>  1467
cccgtgttct gcgttgccgg ccgtgggtgc tctggccaca gtgagttagg ggcgtcggag     60

cgggtttctc caaccgcaat cggctccgct caaggggagg aggagagtcc cttctcggaa    120

ggcctaagga aacgtgtcgt ctggaatggg cttgggggcc acgcctgcac atctccgcga    180

gacagaggga taaagtgaag atggtgctgt tattgttacc tcgagtgcca catgcgacct    240

ctgagatatg tacacagtca ttcttactat cgcactcagc cattcttact acgctaaaga    300

agaaataatt attcgaggat atttgcctgg cccagaagaa acttatgtaa atttcatgaa    360

ctattatatc cgttttcctc ggagtgagag aaaactcttt ttagatatca tctgagaggt    420

agttaatttg gcaccatggg gatacaggga ttgctacaat ttatcaaaga agcttcagaa    480

cccatccatg tgaggaagta taaagggcag gtagtagctg tggatacata ttgctggctt    540

cacaaaggag ctattgcttg tgctgaaaaa ctagccaaag gtgaacctac tgataggtat    600

gtaggatttt gtatgaaatt tgtaaatatg ttactatctc atgggatcaa gcctattctc    660

gtatttgatg gatgtacttt accttctaaa aaggaagtag agagatctag aagagaaaga    720

cgacaagcca atcttcttaa gggaaagcaa cttcttcgtg aggggaaagt ctcggaagct    780

cgagagtgtt tcacccggtc tatcaatatc acacatgcca tggcccacaa agtaattaaa    840

gctgcccggt ctcagggggt agattgcctc gtggctccct atgaagctga tgcgcagttg    900

gcctatctta acaaagcggg aattgtgcaa gccataatta cagaggactc ggatctccta    960

gcttttggct gtaaaaaggt aattttaaag atggaccagt ttggaaatgg acttgaaatt   1020

gatcaagctc ggctaggaat gtgcagacag cttggggatg tattcacgga agagaagttt   1080

cgttacatgt gtattctttc aggttgtgac tacctgtcat cactgcgtgg gattggatta   1140

gcaaaggcat gcaaagtcct aagactagcc aataatccag atatagtaaa ggttatcaag   1200

aaaattggac attatctcaa gatgaatatc acggtaccag aggattacat caacgggttt   1260

attcgggcca acaatacctt cctctatcag ctagtttttg atcccatcaa aaggaaactt   1320

attcctctga acgcctatga agatgatgtt gatcctgaaa cactaagcta cgctgggcaa   1380

tatgttgatg attccatagc tcttcaaata gcacttggaa ataaagatat aaatactttt   1440

gaacagatcg atgactacaa tccagacact gctatgcctg cccattcaag aagtcatagt   1500

tgggatgaca aaacatgtca aaagtcagct aatgttagca gcatttggca taggaattac   1560

tctcccagac cagagtcggg tactgtttca gatgccccac aattgaagga aaatccaagt   1620

actgtgggag tggaacgagt gattagtact aaagggttaa atctcccaag gaaatcatcc   1680

attgtgaaaa gaccaagaag tgcagagctg tcagaagatg acctgttgag tcagtattct   1740

ctttcattta cgaagaagac caagaaaaat agctctgaag gcaataaatc attgagcttt   1800

tctgaagtgt ttgtgcctga cctggtaaat ggacctacta acaaaaagag tgtaagcact   1860

ccacctagga cgagaaataa atttgcaaca tttttacaaa ggaaaaatga agaaagtggt   1920

gcagttgtgg ttccagggac cagaagcagg tttttttgca gttcagattc tactgactgt   1980

gtatcaaaca aagtgagcat ccagcctctg gatgaaactg ctgtcacaga taaagagaac   2040

aatctgcatg aatcagagta tggagaccaa gaaggcaaga gactggttga cacagatgta   2100

gcacgtaatt caagtgatga cattccgaat aatcatattc caggtgatca tattccagac   2160

aaggcaacag tgtttacaga tgaagagtcc tactcttttg agagcagcaa atttacaagg   2220

accatttcac cacccacttt gggaacacta agaagttgtt ttagttggtc tggaggtctt   2280

ggagattttt caagaacgcc gagcccctct ccaagcacag cattgcagca gttccgaaga   2340

aagagcgatt cccccacctc tttgcctgag aataatatgt ctgatgtgtc gcagttaaag   2400

agcgaggagt ccagtgacga tgagtctcat cccttacgag aaggggcatg ttcttcacag   2460

tcccaggaaa gtggagaatt ctcactgcag agttcaaatg catcaaagct ttctcagtgc   2520

tctagtaagg actctgattc agaggaatct gattgcaata ttaagttact tgacagtcaa   2580

agtgaccaga cctccaagct atgtttatct catttctcaa aaaaagacac acctctaagg   2640

aacaaggttc ctgggctata taagtccagt tctgcagact ctctttctac aaccaagatc   2700

aaacctctag gacctgccag agccagtggg ctgagcaaga agccggcaag catccagaag   2760

agaaagcatc ataatgccga gaacaagccg gggttacaga tcaaactcaa tgagctctgg   2820

aaaaactttg gatttaaaaa agattctgaa aagcttcctc cttgtaagaa acccctgtcc   2880

ccagtcagag ataacatcca actaactcca gaagcggaag aggatatatt taacaaacct   2940

gaatgtggcc gtgttcaaag agcaatattc cagtaaatgc agactgctgc aaagcttttg   3000

cctgcaagag aatctgatca atttgaagtc cctgtttggg aatgaggcac ttatcagcat   3060

gaagaatttt ttctcattct gtgccatttt aaaaatagaa tacattttgt atattaactt   3120

taaaaaaaaa aaaaaaaaaa                                               3140


<210>  1468
<211>  846
<212>  PRT
<213>  Homosapiens

<400>  1468

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Gly Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Cys Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210>  1469
<211>  3245
<212>  DNA
<213>  Homosapiens

<400>  1469
cccgtgttct gcgttgccgg ccgtgggtgc tctggccaca gtgagttagg ggcgtcggag     60

cgggtttctc caaccgcaat cggctccgct caaggggagg aggagagtcc cttctcggaa    120

ggcctaagga aacgtgtcgt ctggaatggg cttgggggcc acgcctgcac atctccgcga    180

gacagaggga taaagtgaag atggtgctgt tattgttacc tcgagtgcca catgcgacct    240

ctgagatatg tacacagtca ttcttactat cgcactcagc cattcttact acgctaaaga    300

agaaataatt attcgaggat atttgcctgg cccagaagaa acttatgtaa atttcatgaa    360

ctattatatc cgttttcctc ggagtgagag aaaactcttt ttagatatca tctgagagaa    420

ctagtgaatc ccagtcactg agtggagttg agagtctaag aacctctgaa atttgagaac    480

tgctggacca gagcctttag agctctgata aggtgtcaac agggtagtta atttggcacc    540

atggggatac agggattgct acaatttatc aaagaagctt cagaacccat ccatgtgagg    600

aagtataaag ggcaggtagt agctgtggat acatattgct ggcttcacaa aggagctatt    660

gcttgtgctg aaaaactagc caaaggtgaa cctactgata ggtatgtagg attttgtatg    720

aaatttgtaa atatgttact atctcatggg atcaagccta ttctcgtatt tgatggatgt    780

actttacctt ctaaaaagga agtagagaga tctagaagag aaagacgaca agccaatctt    840

cttaagggaa agcaacttct tcgtgagggg aaagtctcgg aagctcgaga gtgtttcacc    900

cggtctatca atatcacaca tgccatggcc cacaaagtaa ttaaagctgc ccggtctcag    960

ggggtagatt gcctcgtggc tccctatgaa gctgatgcgc agttggccta tcttaacaaa   1020

gcgggaattg tgcaagccat aattacagag gactcggatc tcctagcttt tggctgtaaa   1080

aaggtaattt taaagatgga ccagtttgga aatggacttg aaattgatca agctcggcta   1140

ggaatgtgca gacagcttgg ggatgtattc acggaagaga agtttcgtta catgtgtatt   1200

ctttcaggtt gtgactacct gtcatcactg cgtgggattg gattagcaaa ggcatgcaaa   1260

gtcctaagac tagccaataa tccagatata gtaaaggtta tcaagaaaat tggacattat   1320

ctcaagatga atatcacggt accagaggat tacatcaacg ggtttattcg ggccaacaat   1380

accttcctct atcagctagt ttttgatccc atcaaaagga aacttattcc tctgaacgcc   1440

tatgaagatg atgttgatcc tgaaacacta agctacgctg ggcaatatgt tgatgattcc   1500

atagctcttc aaatagcact tggaaataaa gatataaata cttttgaaca gatcgatgac   1560

tacaatccag acactgctat gcctgcccat tcaagaagtc atagttggga tgacaaaaca   1620

tgtcaaaagt cagctaatgt tagcagcatt tggcatagga attactctcc cagaccagag   1680

tcgggtactg tttcagatgc cccacaattg aaggaaaatc caagtactgt gggagtggaa   1740

cgagtgatta gtactaaagg gttaaatctc ccaaggaaat catccattgt gaaaagacca   1800

agaagtgcag agctgtcaga agatgacctg ttgagtcagt attctctttc atttacgaag   1860

aagaccaaga aaaatagctc tgaaggcaat aaatcattga gcttttctga agtgtttgtg   1920

cctgacctgg taaatggacc tactaacaaa aagagtgtaa gcactccacc taggacgaga   1980

aataaatttg caacattttt acaaaggaaa aatgaagaaa gtggtgcagt tgtggttcca   2040

gggaccagaa gcaggttttt ttgcagttca gattctactg actgtgtatc aaacaaagtg   2100

agcatccagc ctctggatga aactgctgtc acagataaag agaacaatct gcatgaatca   2160

gagtatggag accaagaagg caagagactg gttgacacag atgtagcacg taattcaagt   2220

gatgacattc cgaataatca tattccaggt gatcatattc cagacaaggc aacagtgttt   2280

acagatgaag agtcctactc ttttgagagc agcaaattta caaggaccat ttcaccaccc   2340

actttgggaa cactaagaag ttgttttagt tggtctggag gtcttggaga tttttcaaga   2400

acgccgagcc cctctccaag cacagcattg cagcagttcc gaagaaagag cgattccccc   2460

acctctttgc ctgagaataa tatgtctgat gtgtcgcagt taaagagcga ggagtccagt   2520

gacgatgagt ctcatccctt acgagaaggg gcatgttctt cacagtccca ggaaagtgga   2580

gaattctcac tgcagagttc aaatgcatca aagctttctc agtgctctag taaggactct   2640

gattcagagg aatctgattg caatattaag ttacttgaca gtcaaagtga ccagacctcc   2700

aagctatgtt tatctcattt ctcaaaaaaa gacacacctc taaggaacaa ggttcctggg   2760

ctatataagt ccagttctgc agactctctt tctacaacca agatcaaacc tctaggacct   2820

gccagagcca gtgggctgag caagaagccg gcaagcatcc agaagagaaa gcatcataat   2880

gccgagaaca agccggggtt acagatcaaa ctcaatgagc tctggaaaaa ctttggattt   2940

aaaaaagatt ctgaaaagct tcctccttgt aagaaacccc tgtccccagt cagagataac   3000

atccaactaa ctccagaagc ggaagaggat atatttaaca aacctgaatg tggccgtgtt   3060

caaagagcaa tattccagta aatgcagact gctgcaaagc ttttgcctgc aagagaatct   3120

gatcaatttg aagtccctgt ttgggaatga ggcacttatc agcatgaaga attttttctc   3180

attctgtgcc attttaaaaa tagaatacat tttgtatatt aactttaaaa aaaaaaaaaa   3240

aaaaa                                                               3245


<210>  1470
<211>  846
<212>  PRT
<213>  Homosapiens

<400>  1470

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Gly Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Cys Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210>  1471
<211>  1701
<212>  DNA
<213>  Homosapiens

<400>  1471
atgtcttcca tccgcttcct gtgccagcgc tgccaccagg ccctgaagct gagcggctcc     60

tcggagtcta ggagcctccc tgcagccccg gcgcccacct ctgggcaggc tgagcccgga    120

gacacccggg agcccggcgt caccaccagg gaggtgacag acgctgagga gcaacaggac    180

ggtgcctcta gcagatcccc tccaggcgat ggcagtgtgt ccaagggcca tgccaacatc    240

ttcaccctgc tgggggagct tggcgccatg cacatgctca gtagcatcca gaaggcagct    300

ggtgacattt ttgacatagt ctctggccaa gcagttgtgg accatcccct gtgtgaagaa    360

tgcaccgaca gtcttttaga gcagctggac atccagctcg ctctcacaga agctgacagt    420

cagaactacc aacgctgcct ggagaccggg gagctggcga ccagcgagga cgaggcggcg    480

gcgctgcggg cggagctgcg ggacctggag ctggaggagg ccaggctggt gcaggagctg    540

gaggatgtgg acaggaacaa tgcaagagca gcggcggatc tccaggcagc ccaggcagag    600

gctgcggagc tggaccagca ggagaggcag cactacaggg actacagtgc cttgaagcgg    660

cagcagctgg aactgcttga tcagctgggg aacgtggaga accagctgca gtatgccagg    720

gtccagaggg accggctgaa ggaaatcaac tgtttcaccg ccacgtttga gatctgggtg    780

gagggcccct tgggcgtcat caataacttc aggttgggcc gcctccccac tgtccgtgtg    840

ggctggaatg agattaacac tgcctgggga caggcggcct tgctgctcct taccctggcc    900

aatacaattg gactgcagtt tcagaggtat cgactcatcc cctgcggaaa ccattcgtat    960

ctgaagtctt taacagatga ccgcactgag ctgccgttgt tctgttatgg ggggcaggat   1020

gttttcctca ataacaagta tgaccgcgcg atggtggcct tcctggactg catgcagcag   1080

ttcaaggaag aggctgagaa gggtgagctg ggcctctctc tgccctacgg gatccaggtg   1140

gagacaggcc tgatggagga cgttggcggc cgaggggaat gctattccat cagaacccat   1200

ctgaacacgc aggagctgtg gacaaaggca ctcaagttca tgcttataaa tttcaagtgg   1260

agtctcatct gggttgcctc aagagaaggt gaagaggcac agaagacggt gctcttctgc   1320

ctgagtgagg acaagaacat catcctgggg gaaggcaatg agatcctggt gggtgacgtg   1380

ggccagacca tccatgaccc ctacaccgcc tttgtcaaga tgctgccaga taagaactgc   1440

cactgtgccc tctacgacac aatctatgag accaaggaga gcaagaagga ggacctggtg   1500

tttatcttct gggccactga atgggcaccc cttacgagca aaatgatcta tgccagctcc   1560

aaaaatgcca tcaagaagaa gctgacaggg atcaagcaag aattacaagc aaactgctac   1620

gaggaggtca aggaccgctg caccctggca gagaaggtgg ggggcagtgc cttcatcccc   1680

ctggagggca agcctttgtg a                                             1701


<210>  1472
<211>  566
<212>  PRT
<213>  Homosapiens

<400>  1472

Met Ser Ser Ile Arg Phe Leu Cys Gln Arg Cys His Gln Ala Leu Lys 
1               5                   10                  15      


Leu Ser Gly Ser Ser Glu Ser Arg Ser Leu Pro Ala Ala Pro Ala Pro 
            20                  25                  30          


Thr Ser Gly Gln Ala Glu Pro Gly Asp Thr Arg Glu Pro Gly Val Thr 
        35                  40                  45              


Thr Arg Glu Val Thr Asp Ala Glu Glu Gln Gln Asp Gly Ala Ser Ser 
    50                  55                  60                  


Arg Ser Pro Pro Gly Asp Gly Ser Val Ser Lys Gly His Ala Asn Ile 
65                  70                  75                  80  


Phe Thr Leu Leu Gly Glu Leu Gly Ala Met His Met Leu Ser Ser Ile 
                85                  90                  95      


Gln Lys Ala Ala Gly Asp Ile Phe Asp Ile Val Ser Gly Gln Ala Val 
            100                 105                 110         


Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Ser Leu Leu Glu Gln 
        115                 120                 125             


Leu Asp Ile Gln Leu Ala Leu Thr Glu Ala Asp Ser Gln Asn Tyr Gln 
    130                 135                 140                 


Arg Cys Leu Glu Thr Gly Glu Leu Ala Thr Ser Glu Asp Glu Ala Ala 
145                 150                 155                 160 


Ala Leu Arg Ala Glu Leu Arg Asp Leu Glu Leu Glu Glu Ala Arg Leu 
                165                 170                 175     


Val Gln Glu Leu Glu Asp Val Asp Arg Asn Asn Ala Arg Ala Ala Ala 
            180                 185                 190         


Asp Leu Gln Ala Ala Gln Ala Glu Ala Ala Glu Leu Asp Gln Gln Glu 
        195                 200                 205             


Arg Gln His Tyr Arg Asp Tyr Ser Ala Leu Lys Arg Gln Gln Leu Glu 
    210                 215                 220                 


Leu Leu Asp Gln Leu Gly Asn Val Glu Asn Gln Leu Gln Tyr Ala Arg 
225                 230                 235                 240 


Val Gln Arg Asp Arg Leu Lys Glu Ile Asn Cys Phe Thr Ala Thr Phe 
                245                 250                 255     


Glu Ile Trp Val Glu Gly Pro Leu Gly Val Ile Asn Asn Phe Arg Leu 
            260                 265                 270         


Gly Arg Leu Pro Thr Val Arg Val Gly Trp Asn Glu Ile Asn Thr Ala 
        275                 280                 285             


Trp Gly Gln Ala Ala Leu Leu Leu Leu Thr Leu Ala Asn Thr Ile Gly 
    290                 295                 300                 


Leu Gln Phe Gln Arg Tyr Arg Leu Ile Pro Cys Gly Asn His Ser Tyr 
305                 310                 315                 320 


Leu Lys Ser Leu Thr Asp Asp Arg Thr Glu Leu Pro Leu Phe Cys Tyr 
                325                 330                 335     


Gly Gly Gln Asp Val Phe Leu Asn Asn Lys Tyr Asp Arg Ala Met Val 
            340                 345                 350         


Ala Phe Leu Asp Cys Met Gln Gln Phe Lys Glu Glu Ala Glu Lys Gly 
        355                 360                 365             


Glu Leu Gly Leu Ser Leu Pro Tyr Gly Ile Gln Val Glu Thr Gly Leu 
    370                 375                 380                 


Met Glu Asp Val Gly Gly Arg Gly Glu Cys Tyr Ser Ile Arg Thr His 
385                 390                 395                 400 


Leu Asn Thr Gln Glu Leu Trp Thr Lys Ala Leu Lys Phe Met Leu Ile 
                405                 410                 415     


Asn Phe Lys Trp Ser Leu Ile Trp Val Ala Ser Arg Glu Gly Glu Glu 
            420                 425                 430         


Ala Gln Lys Thr Val Leu Phe Cys Leu Ser Glu Asp Lys Asn Ile Ile 
        435                 440                 445             


Leu Gly Glu Gly Asn Glu Ile Leu Val Gly Asp Val Gly Gln Thr Ile 
    450                 455                 460                 


His Asp Pro Tyr Thr Ala Phe Val Lys Met Leu Pro Asp Lys Asn Cys 
465                 470                 475                 480 


His Cys Ala Leu Tyr Asp Thr Ile Tyr Glu Thr Lys Glu Ser Lys Lys 
                485                 490                 495     


Glu Asp Leu Val Phe Ile Phe Trp Ala Thr Glu Trp Ala Pro Leu Thr 
            500                 505                 510         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asn Ala Ile Lys Lys Lys Leu 
        515                 520                 525             


Thr Gly Ile Lys Gln Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    530                 535                 540                 


Asp Arg Cys Thr Leu Ala Glu Lys Val Gly Gly Ser Ala Phe Ile Pro 
545                 550                 555                 560 


Leu Glu Gly Lys Pro Leu 
                565     


<210>  1473
<211>  1181
<212>  DNA
<213>  Homosapiens

<400>  1473
gttaggtccc ggttgcggga cagttttttt ttctttttta aaacagacac agctactgag     60

tgcaatgccg cctccacaga aaatcccaag cgtcagaccc ttcaagcaga ggaaaagctt    120

ggcaatcaga caagaggaag ttgctggaat ccgggcaaag ttccccaaca aaatcccggt    180

ggtagtggag cgctacccca gggagacgtt cctgcccccg ctggacaaaa ccaagttcct    240

ggtcccgcag gagctgacca tgacccagtt cctcagcatc atccggagcc gcatggtcct    300

gagagccacg gaagcctttt acttgctggt gaacaacaag agcctggtca gcatgagcgc    360

aaccatggca gagatctaca gagactacaa ggatgaggat ggcttcgtgt acatgaccta    420

cgcctcccag gagacatttg gctgcctgga gtcagcagcc cccagggatg ggagcagcct    480

tgaggacaga ccctgcaatc ctctctagcc catgtcggga aggatgtgtg ctctgacaga    540

cgtgtcagat gctggcagaa gggattggtt ttctcctgtg tatacagtgg aggagtctga    600

gaagcaggga tgcctggggt gatcagctcc aaccagtggc agcagagtgg tggctcttcc    660

tagtttagtt tttgtgctcc gtgttcttgt gtccttctaa gaaaaatgtg ggctgctctt    720

gaaagttata taattatcat tttttttttt ttgaaacagg gtcttgctct attgcctagg    780

ctggagcaca gtggcatgat cttggctcac tgcaacctcc gcctcctggg ttcaagtgat    840

tcttctgcct ccaccccccg agtggctggt attacaagca catgccacca caccaggcta    900

atttttgtat ttttagtaga gacggggttt caccatgttg gccaggctgg tctcgaactc    960

ctgacctcag gtgatccacc cacctcggcc tcccaaagtg ctgggattac aggcgtgagc   1020

cactgcatcc agccatataa ccgtattcta aataagaaat ggttggcttg tgtgatggtt   1080

ttgtgtaatg agctagagat aatattttaa gtgtcttctg tggtatatgt gggagggcca   1140

ttaaggagtg ggtttcactc cctgcatgtg ggcaggtgtc c                       1181


<210>  1474
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  1474

Met Pro Pro Pro Gln Lys Ile Pro Ser Val Arg Pro Phe Lys Gln Arg 
1               5                   10                  15      


Lys Ser Leu Ala Ile Arg Gln Glu Glu Val Ala Gly Ile Arg Ala Lys 
            20                  25                  30          


Phe Pro Asn Lys Ile Pro Val Val Val Glu Arg Tyr Pro Arg Glu Thr 
        35                  40                  45              


Phe Leu Pro Pro Leu Asp Lys Thr Lys Phe Leu Val Pro Gln Glu Leu 
    50                  55                  60                  


Thr Met Thr Gln Phe Leu Ser Ile Ile Arg Ser Arg Met Val Leu Arg 
65                  70                  75                  80  


Ala Thr Glu Ala Phe Tyr Leu Leu Val Asn Asn Lys Ser Leu Val Ser 
                85                  90                  95      


Met Ser Ala Thr Met Ala Glu Ile Tyr Arg Asp Tyr Lys Asp Glu Asp 
            100                 105                 110         


Gly Phe Val Tyr Met Thr Tyr Ala Ser Gln Glu Thr Phe Gly Cys Leu 
        115                 120                 125             


Glu Ser Ala Ala Pro Arg Asp Gly Ser Ser Leu Glu Asp Arg Pro Cys 
    130                 135                 140                 


Asn Pro Leu 
145         


<210>  1475
<211>  2729
<212>  DNA
<213>  Homosapiens

<400>  1475
gtaggtgccg caaggagccg gcgagcggag cgcccgctcg ggaccgcagc cgccgggcga     60

cgtcgccgcc gcaccgggca cttctgtctc cccggagcag ctcctccagc tcagtctcca    120

gctccacctc cggctcccgc tgggcctccc gctcgccctc cgcgcccggc tccccgcgcg    180

cccgtcccga gtccgctgct cgccggcggc cgcccggtca tgtcaggatg gagatccggc    240

agcacgagtg gctctcggcc tccccccatg agggcttcga gcagatgagg ctcaaaagcc    300

gccccaagga gccctcccca agcctgaccc gagtgggcgc gaacttctac agcagcgtca    360

agcagcagga ctacagcgcc agcgtctggc ttcggaggaa agacaagctg gagcactccc    420

agcagaagtg catcgtgatc tttgccctgg tgtgctgctt tgccattctg gttgcactga    480

tcttttcagc cgtggacatc atgggagagg atgaggatgg actctcagaa aaaaattgcc    540

aaaataaatg tcggtaagag aattgccctg gtggaaaata ttcctgaagg ccttaactat    600

tcagaaaatg caccatttca cttatcactt ttccaaggct ggatgaattt actcaacatg    660

gccaaaaagt ctgttgacat agtgtcttcc cattgggatc tcaaccacac tcatccatca    720

gcatgtcagg gtcaacgtct ttttgaaaag ttgctccagc tgacttcgca aaatattgaa    780

atcaagctag tgagtgatgt aacagctgat tcaaaggtat tagaagcctt gaaattaaag    840

ggagccgagg tgacgtacat gaacatgacc gcttacaaca agggccggct gcagtcctcc    900

ttctggatcg tggacaaaca gcacgtgtat atcggcagtg ccggtttgga ctggcaatcc    960

ctgggacaga tgaaagaact cggtgtcatc ttctacaact gcagctgcct ggtcctagat   1020

ttacaaagga tatttgctct atatagttca ttaaaattca aaagcagagt gcctcaaacc   1080

tggtccaaaa gactctatgg agtctatgac aatgaaaaga aattgcaact tcagttgaat   1140

gaaaccaaat ctcaagcatt tgtatcgaat tctccaaaac tcttttgccc taaaaacaga   1200

agttttgaca tagatgccat ctacagtgtg atagatgatg ccaagcagta tgtgtacatc   1260

gctgtcatgg actacctgcc tatctccagc acaagcacca aaaggactta ctggccagac   1320

ttggatgcaa aaataagaga agcattagtt ttacgaagcg ttagagttcg actcctttta   1380

agcttctgga aggaaactga tccccttacg tttaacttta tttcatctct taaagcgatt   1440

tgcactgaaa tagccaactg cagtttgaaa gttaaatttt ttgatctgga aagagagaat   1500

gcttgtgcta caaaagaaca aaagaatcac acctttccta ggttaaatcg caacaagtac   1560

atggtgacag atggagcagc ttatattgga aattttgatt gggtagggaa tgatttcact   1620

cagaatgctg gcacgggcct tgttatcaac caggcagatg tgaggaacaa cagaagcatc   1680

attaagcaac ttaaagatgt gtttgaaagg gactggtatt caccgtatgc caaaacctta   1740

cagccaacca aacagccgaa ctgctcaagc ctgttcaaac tcaaacccct ctccaacaaa   1800

actgccacag acgacacagg cggaaaggat ccccggaacg tataacatga tgaagaaact   1860

gacaggacag ctctgtattt catatttata cataaaggac ttgaggagag aaaaaacact   1920

ttaatatgtc tcttttttta gggaaaaagc acacttataa aaaatattct ctgaacaaca   1980

cataatacct atctaacaat atcttagcgt cgtgtacact aaaattaaga cttttgtatt   2040

tgttacctct gacagagaat gtcattctgg cgtagaagtt agtttttacg tttgcataca   2100

aattttaaga ctttcattcc tgctcctttc tagttttaga actttttctg ctgacctacc   2160

cggtcagttg ttaggaagct tagcatgagg tgggctcttt aacaccattc tgagaactgt   2220

tgatttagag aggaaggtga ggattttgcc ttggagaaga gactgataaa accaagtgtt   2280

tattcttgta aatcgtctcc aagacctaca cagtcagcta agcatgaata gcttacatct   2340

catgccagcc ttcaacaccc ttgaaaaata tccttttctg tcttgctcat tttcttctta   2400

taccataagt tttatttggt atcattttct cttctcacaa aatgttccta ttatatagca   2460

ttttctgtat tcacctcaac attacttcta actatgataa catcttttga aaacatacaa   2520

atttttcaga atggatacta agtggaaata gcagtctttc attttcacct ttcaactgaa   2580

tccttttttc ccctaccgaa ttggtattta aaaaaaatca cagtcagcaa tatgtatcct   2640

ttctctcaag ctcagaaaaa ttatgtagcc acctgctaat atccagcaag ctatcaagtc   2700

tgcattttgg gaataaagta gtttttcac                                     2729


<210>  1476
<211>  444
<212>  PRT
<213>  Homosapiens

<400>  1476

Met Arg Met Asp Ser Gln Lys Lys Ile Ala Lys Ile Asn Val Gly Lys 
1               5                   10                  15      


Arg Ile Ala Leu Val Glu Asn Ile Pro Glu Gly Leu Asn Tyr Ser Glu 
            20                  25                  30          


Asn Ala Pro Phe His Leu Ser Leu Phe Gln Gly Trp Met Asn Leu Leu 
        35                  40                  45              


Asn Met Ala Lys Lys Ser Val Asp Ile Val Ser Ser His Trp Asp Leu 
    50                  55                  60                  


Asn His Thr His Pro Ser Ala Cys Gln Gly Gln Arg Leu Phe Glu Lys 
65                  70                  75                  80  


Leu Leu Gln Leu Thr Ser Gln Asn Ile Glu Ile Lys Leu Val Ser Asp 
                85                  90                  95      


Val Thr Ala Asp Ser Lys Val Leu Glu Ala Leu Lys Leu Lys Gly Ala 
            100                 105                 110         


Glu Val Thr Tyr Met Asn Met Thr Ala Tyr Asn Lys Gly Arg Leu Gln 
        115                 120                 125             


Ser Ser Phe Trp Ile Val Asp Lys Gln His Val Tyr Ile Gly Ser Ala 
    130                 135                 140                 


Gly Leu Asp Trp Gln Ser Leu Gly Gln Met Lys Glu Leu Gly Val Ile 
145                 150                 155                 160 


Phe Tyr Asn Cys Ser Cys Leu Val Leu Asp Leu Gln Arg Ile Phe Ala 
                165                 170                 175     


Leu Tyr Ser Ser Leu Lys Phe Lys Ser Arg Val Pro Gln Thr Trp Ser 
            180                 185                 190         


Lys Arg Leu Tyr Gly Val Tyr Asp Asn Glu Lys Lys Leu Gln Leu Gln 
        195                 200                 205             


Leu Asn Glu Thr Lys Ser Gln Ala Phe Val Ser Asn Ser Pro Lys Leu 
    210                 215                 220                 


Phe Cys Pro Lys Asn Arg Ser Phe Asp Ile Asp Ala Ile Tyr Ser Val 
225                 230                 235                 240 


Ile Asp Asp Ala Lys Gln Tyr Val Tyr Ile Ala Val Met Asp Tyr Leu 
                245                 250                 255     


Pro Ile Ser Ser Thr Ser Thr Lys Arg Thr Tyr Trp Pro Asp Leu Asp 
            260                 265                 270         


Ala Lys Ile Arg Glu Ala Leu Val Leu Arg Ser Val Arg Val Arg Leu 
        275                 280                 285             


Leu Leu Ser Phe Trp Lys Glu Thr Asp Pro Leu Thr Phe Asn Phe Ile 
    290                 295                 300                 


Ser Ser Leu Lys Ala Ile Cys Thr Glu Ile Ala Asn Cys Ser Leu Lys 
305                 310                 315                 320 


Val Lys Phe Phe Asp Leu Glu Arg Glu Asn Ala Cys Ala Thr Lys Glu 
                325                 330                 335     


Gln Lys Asn His Thr Phe Pro Arg Leu Asn Arg Asn Lys Tyr Met Val 
            340                 345                 350         


Thr Asp Gly Ala Ala Tyr Ile Gly Asn Phe Asp Trp Val Gly Asn Asp 
        355                 360                 365             


Phe Thr Gln Asn Ala Gly Thr Gly Leu Val Ile Asn Gln Ala Asp Val 
    370                 375                 380                 


Arg Asn Asn Arg Ser Ile Ile Lys Gln Leu Lys Asp Val Phe Glu Arg 
385                 390                 395                 400 


Asp Trp Tyr Ser Pro Tyr Ala Lys Thr Leu Gln Pro Thr Lys Gln Pro 
                405                 410                 415     


Asn Cys Ser Ser Leu Phe Lys Leu Lys Pro Leu Ser Asn Lys Thr Ala 
            420                 425                 430         


Thr Asp Asp Thr Gly Gly Lys Asp Pro Arg Asn Val 
        435                 440                 


<210>  1477
<211>  4082
<212>  DNA
<213>  Homosapiens

<400>  1477
gaggactgcg agcacagcgg cggccgggtg gcgggggtga gtggggccag cggggctgga     60

cagcagcggg ccccgggcgc cgccgccgcg atccctcccc gcgcccgccg agcacatcgc    120

cgccgccgag atgggccctc cgcggcaccc ccaggccggc gagatagaag cgggcggtgc    180

gggcggcggg cggcggctac aggtggaaat gagttctcaa cagtttcctc ggttaggagc    240

cccttctacc gggctgagcc aggccccttc tcagattgca aacagtggtt ctgctggatt    300

gataaaccca gctgctacag tcaatgatga atctggtcga gattctgaag tcagtgccag    360

ggagcacatg agttccagca gctccctcca gtcccgggag gagaagcaag agcctgttgt    420

ggtaaggccc tatccacagg tgcagatgtt gtcgacacac catgctgtcg catcagccac    480

acctgttgca gtgacagccc cgccagcaca cctgacgcca gcagtgccac tttcattttc    540

ggagggactt atgaagccgc ccccgaagcc caccatgcct agccgtccca ttgctcctgc    600

tccaccttct accctgtcac ttccccccaa ggttccaggg caggttaccg ttaccatgga    660

gagtagcatc cctcaagctt cagccattcc tgtggcaaca atcagtggac aacagggcca    720

tcccagtaac ctgcatcaca tcatgactac aaatgtgcaa atgtctatca tccgcagcaa    780

tgctcctggg ccccctcttc acattggagc ttctcattta cctcgaggtg cagctgctgc    840

tgctgtgatg tccagttcta aagtaaccac agtcctgagg ccgacctcac agctgccaaa    900

tgctgctact gctcagccag cagtacagca catcattcac caaccaatcc agtctcggcc    960

acctgtgacc acctccaatg ccatccctcc tgctgtggta gcaactgtct cagccaccag   1020

agctcagtct ccagtcatca ctacgacagc ggcgcatgct actgattcag cacttagtag   1080

gccaaccttg tctatccagc atcctccatc tgcagcaatc agtattcagc gtcctgccca   1140

gtcacgagat gtcacaacaa gaatcacact accatctcac cctgcattag ggacgccaaa   1200

acagcagctt catacaatgg ctcagaaaac aatcttcagt actggcacgc cagtggctgc   1260

agccacagta gcacctattt tggcaaccaa caccattcct tcagcgacca cagctggatc   1320

tgtgtcacac acgcaagctc ccacaagtac cattgttacc atgacagtac cctcccattc   1380

ctcccatgct actgctgtga ccacctcaaa catcccagtc gccaaggtgg tgccccagca   1440

gatcacgcac acttctcctc ggatccagcc agactaccct gccgagagga gtagcctgat   1500

tcccatctcc ggacatcggg cctctcccaa tcctgtggcc atggaaaccc gaagtgacaa   1560

cagaccgtct gttcccgttc agttccaata ttttttgcca acttaccccc cttctgcata   1620

cccactggcg gcacatacct acaccccaat caccagttcc gtgtccacta tccgacagta   1680

tccagtttca gctcaggctc caaactctgc catcacagct cagactggtg ttggggtagc   1740

gtctaccgtc cacctaaacc ccatgcagtt gatgacagtg gatgcatcgc atgctcgaca   1800

tattcaaggg atccagccag cacccatcag tacccagggt atccagccgg cccccattgg   1860

gaccccaggg atacagcctg caccacttgg cacacaggga attcactcag caaccccaat   1920

caacacacaa gggcttcagc ctgcacctat gggtactcag cagcctcagc ctgaaggaaa   1980

gacttcagca gtggtgttgg cagatggagc cacaattgtg gccaacccta ttagcaatcc   2040

attcagtgct gctccagcag caacaaccgt ggtgcagacc cacagccaga gtgctagcac   2100

caacgctccc gcccagggct catcgccacg gccaagcata ctccggaaga aacctgccac   2160

agatggtgcc aaacccaagt ctgaaatcca cgtgtctatg gccactccgg tcactgtgtc   2220

catggagact gtatccaatc aaaataatga tcagcctacc attgccgtcc ctccaactgc   2280

ccagcagccc ccaccgacca ttccaactat gattgcagca gccagtcccc cgtcacaacc   2340

agccgttgcc ctttcaacca ttcctggagc ggtccccatc actccaccca tcaccaccat   2400

tgcagctgca ccacctccat cagtcactgt gggtggcagt ctttcctccg tcttgggccc   2460

tcccgttcct gaaattaaag tgaaagaaga agtagaacca atggatatca tgaggccagt   2520

ttctgcagtt cctccactgg ctaccaacac tgtgtctcca tctcttgcat tgctggcaaa   2580

caacttgtcc atgcctacaa gtgacctacc acctggtgcc tccccaagga aaaagcctcg   2640

aaagcaacag catgtgatct caacagaaga aggtgacatg atggagacaa acagcactga   2700

tgatgagaag tccactgcca agagtcttct ggtgaaggct gagaagcgca agtctcctcc   2760

caaggagtat attgatgagg aaggtgtgag atatgtccca gtgcgtccaa gaccccccat   2820

tactttgctt cgtcactatc ggaacccctg gaaagctgct taccaccact ttcagaggta   2880

cagtgacgtc cgggtcaaag aggagaagaa agctatgctg caggaaatag ctaatcagaa   2940

aggagtatcc tgtcgtgctc aaggctggaa agtccacctc tgtgctgccc agttactaca   3000

gctgacgaat ctagaacatg atgtctatga aagacttact aacctgcagg aagggattat   3060

cccaaagaaa aaagcagcaa cagatgatga tctccaccga ataaacgaac tgatacaggg   3120

aaatatgcag aggtgtaaac ttgtgatgga tcaaatcagt gaagccagag actccatgct   3180

taaggtttta gatcataaag accgtgtcct gaagctgctt aacaagaacg ggactgtcaa   3240

aaaagtgtcc aaattgaagc gaaaggaaaa agtctagacc cagaacaatc aggagattgg   3300

aagcaaattt atgaagaatg atggtggggg tggggggagg gttttggttt tttccaaagt   3360

ggaacattga aataaaggaa gtgttcctta gttcccgtgt gaaagcagag gaacccatga   3420

catccaaggg cgtgaaagga tcagagctga ctggacatag tgagctgcct tcttgcgttc   3480

gggtgcaccc ctgttaaacc tgatctgtgt cataagtgac tccggatgca tcagtgtcca   3540

ccagttggaa gcaatgacaa ggatggctgg ctggtgtttt tcagccttcc ggtttataga   3600

ctgtatttat ctagtggatt cctgcaggcc ccatactgag cctggactga aagtatccac   3660

tcggaccatc tgttatctct ctacactgaa aataaaacct cttccaccca ccccattcgg   3720

ttcttctgcc tgaccttcaa atgcccatgt tggcctttta cagcagtgcc acggcaccaa   3780

gcgagctgcc acatctcaca ctctaaaggg tttgaactat tagttcttgt cattttttaa   3840

aaaaaaccat tcccaagtga aattgttata tcgtctgtct tgcgtgtgtc agaactgggt   3900

ttttgtggag gttcagagca ggcaacacca taagttgctc tcagatcctt gttctgaagt   3960

acattcttgg ttatctgtac ttctgtagct ggtgtgatgc tgttaattgt atgtaccaca   4020

catctccaga cgttaataaa ggactcaaag aggtttttgt aaaaaaaaaa aaaaaaaaaa   4080

aa                                                                  4082


<210>  1478
<211>  1048
<212>  PRT
<213>  Homosapiens

<400>  1478

Met Gly Pro Pro Arg His Pro Gln Ala Gly Glu Ile Glu Ala Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Arg Arg Leu Gln Val Glu Met Ser Ser Gln Gln Phe 
            20                  25                  30          


Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu Ser Gln Ala Pro Ser Gln 
        35                  40                  45              


Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile Asn Pro Ala Ala Thr Val 
    50                  55                  60                  


Asn Asp Glu Ser Gly Arg Asp Ser Glu Val Ser Ala Arg Glu His Met 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu Glu Lys Gln Glu Pro Val 
                85                  90                  95      


Val Val Arg Pro Tyr Pro Gln Val Gln Met Leu Ser Thr His His Ala 
            100                 105                 110         


Val Ala Ser Ala Thr Pro Val Ala Val Thr Ala Pro Pro Ala His Leu 
        115                 120                 125             


Thr Pro Ala Val Pro Leu Ser Phe Ser Glu Gly Leu Met Lys Pro Pro 
    130                 135                 140                 


Pro Lys Pro Thr Met Pro Ser Arg Pro Ile Ala Pro Ala Pro Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Pro Pro Lys Val Pro Gly Gln Val Thr Val Thr Met 
                165                 170                 175     


Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile Pro Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Gln Gln Gly His Pro Ser Asn Leu His His Ile Met Thr Thr Asn 
        195                 200                 205             


Val Gln Met Ser Ile Ile Arg Ser Asn Ala Pro Gly Pro Pro Leu His 
    210                 215                 220                 


Ile Gly Ala Ser His Leu Pro Arg Gly Ala Ala Ala Ala Ala Val Met 
225                 230                 235                 240 


Ser Ser Ser Lys Val Thr Thr Val Leu Arg Pro Thr Ser Gln Leu Pro 
                245                 250                 255     


Asn Ala Ala Thr Ala Gln Pro Ala Val Gln His Ile Ile His Gln Pro 
            260                 265                 270         


Ile Gln Ser Arg Pro Pro Val Thr Thr Ser Asn Ala Ile Pro Pro Ala 
        275                 280                 285             


Val Val Ala Thr Val Ser Ala Thr Arg Ala Gln Ser Pro Val Ile Thr 
    290                 295                 300                 


Thr Thr Ala Ala His Ala Thr Asp Ser Ala Leu Ser Arg Pro Thr Leu 
305                 310                 315                 320 


Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser Ile Gln Arg Pro Ala 
                325                 330                 335     


Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu Pro Ser His Pro Ala 
            340                 345                 350         


Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met Ala Gln Lys Thr Ile 
        355                 360                 365             


Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr Val Ala Pro Ile Leu 
    370                 375                 380                 


Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala Gly Ser Val Ser His 
385                 390                 395                 400 


Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met Thr Val Pro Ser His 
                405                 410                 415     


Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn Ile Pro Val Ala Lys 
            420                 425                 430         


Val Val Pro Gln Gln Ile Thr His Thr Ser Pro Arg Ile Gln Pro Asp 
        435                 440                 445             


Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile Ser Gly His Arg Ala 
    450                 455                 460                 


Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser Asp Asn Arg Pro Ser 
465                 470                 475                 480 


Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr Tyr Pro Pro Ser Ala 
                485                 490                 495     


Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile Thr Ser Ser Val Ser 
            500                 505                 510         


Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala Pro Asn Ser Ala Ile 
        515                 520                 525             


Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr Val His Leu Asn Pro 
    530                 535                 540                 


Met Gln Leu Met Thr Val Asp Ala Ser His Ala Arg His Ile Gln Gly 
545                 550                 555                 560 


Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile Gln Pro Ala Pro Ile 
                565                 570                 575     


Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly Thr Gln Gly Ile His 
            580                 585                 590         


Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln Pro Ala Pro Met Gly 
        595                 600                 605             


Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser Ala Val Val Leu Ala 
    610                 615                 620                 


Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser Asn Pro Phe Ser Ala 
625                 630                 635                 640 


Ala Pro Ala Ala Thr Thr Val Val Gln Thr His Ser Gln Ser Ala Ser 
                645                 650                 655     


Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg Pro Ser Ile Leu Arg 
            660                 665                 670         


Lys Lys Pro Ala Thr Asp Gly Ala Lys Pro Lys Ser Glu Ile His Val 
        675                 680                 685             


Ser Met Ala Thr Pro Val Thr Val Ser Met Glu Thr Val Ser Asn Gln 
    690                 695                 700                 


Asn Asn Asp Gln Pro Thr Ile Ala Val Pro Pro Thr Ala Gln Gln Pro 
705                 710                 715                 720 


Pro Pro Thr Ile Pro Thr Met Ile Ala Ala Ala Ser Pro Pro Ser Gln 
                725                 730                 735     


Pro Ala Val Ala Leu Ser Thr Ile Pro Gly Ala Val Pro Ile Thr Pro 
            740                 745                 750         


Pro Ile Thr Thr Ile Ala Ala Ala Pro Pro Pro Ser Val Thr Val Gly 
        755                 760                 765             


Gly Ser Leu Ser Ser Val Leu Gly Pro Pro Val Pro Glu Ile Lys Val 
    770                 775                 780                 


Lys Glu Glu Val Glu Pro Met Asp Ile Met Arg Pro Val Ser Ala Val 
785                 790                 795                 800 


Pro Pro Leu Ala Thr Asn Thr Val Ser Pro Ser Leu Ala Leu Leu Ala 
                805                 810                 815     


Asn Asn Leu Ser Met Pro Thr Ser Asp Leu Pro Pro Gly Ala Ser Pro 
            820                 825                 830         


Arg Lys Lys Pro Arg Lys Gln Gln His Val Ile Ser Thr Glu Glu Gly 
        835                 840                 845             


Asp Met Met Glu Thr Asn Ser Thr Asp Asp Glu Lys Ser Thr Ala Lys 
    850                 855                 860                 


Ser Leu Leu Val Lys Ala Glu Lys Arg Lys Ser Pro Pro Lys Glu Tyr 
865                 870                 875                 880 


Ile Asp Glu Glu Gly Val Arg Tyr Val Pro Val Arg Pro Arg Pro Pro 
                885                 890                 895     


Ile Thr Leu Leu Arg His Tyr Arg Asn Pro Trp Lys Ala Ala Tyr His 
            900                 905                 910         


His Phe Gln Arg Tyr Ser Asp Val Arg Val Lys Glu Glu Lys Lys Ala 
        915                 920                 925             


Met Leu Gln Glu Ile Ala Asn Gln Lys Gly Val Ser Cys Arg Ala Gln 
    930                 935                 940                 


Gly Trp Lys Val His Leu Cys Ala Ala Gln Leu Leu Gln Leu Thr Asn 
945                 950                 955                 960 


Leu Glu His Asp Val Tyr Glu Arg Leu Thr Asn Leu Gln Glu Gly Ile 
                965                 970                 975     


Ile Pro Lys Lys Lys Ala Ala Thr Asp Asp Asp Leu His Arg Ile Asn 
            980                 985                 990         


Glu Leu Ile Gln Gly Asn Met Gln  Arg Cys Lys Leu Val  Met Asp Gln 
        995                 1000                 1005             


Ile Ser  Glu Ala Arg Asp Ser  Met Leu Lys Val Leu  Asp His Lys 
    1010                 1015                 1020             


Asp Arg  Val Leu Lys Leu Leu  Asn Lys Asn Gly Thr  Val Lys Lys 
    1025                 1030                 1035             


Val Ser  Lys Leu Lys Arg Lys  Glu Lys Val 
    1040                 1045             


<210>  1479
<211>  6385
<212>  DNA
<213>  Homosapiens

<400>  1479
tgtctctggc actgtggcgg actgaccacg gcccgggcat gggctgcaag ggagacgcga     60

gcggtgcgtg tgccgcgggt gcgctgccgg tgacaggagt ttgctataaa atgggagttc    120

tggttgtact cactgttctg tggctgttct cctcagtaaa ggccgactca aaagccatta    180

caacctctct tacaacaaaa tggttttcca ctccattgtt gttagaagcc agtgagtttt    240

tagcagaaga cagtcaagag aaattttgga attttgtaga agccagtcaa aatattggat    300

catcagatca tgacggtacc gattattcct actatcatgc aatattggag gctgcatttc    360

agtttctgtc acccctccag cagaatttgt ttaaattttg tctgtccctt cgttcttact    420

cagctacaat ccaagccttc cagcagatag cagctgatga acctccacca gaaggatgta    480

attcgttttt ttcagtgcat ggaaagaaga cttgtgaatc tgataccctt gaggctcttc    540

tactgacagc ctctgaaaga cccaaacctt tattgttcaa aggagatcac agatatccct    600

cgtctaatcc tgaaagccct gtggtgattt tctactctga gattggctct gaggaatttt    660

ccaattttca ccgccagctt atatcaaaaa gcaatgcagg caaaatcaat tatgtattca    720

gacattatat atttaatccc aggaaggagc ctgtttacct ctctggctat ggcgtggaat    780

tggccattaa gagcactgag tacaaggcca aggatgatac tcaggtgaaa ggaactgagg    840

taaacaccac agtgattggt gaaaatgatc ctattgatga ggttcagggg ttcctctttg    900

gaaaattaag agatctgcac cccgacctgg agggacagtt gaaagaactc agaaagcatc    960

ttgtagagag caccaatgaa atggcacctt taaaggtttg gcagttgcaa gatctcagtt   1020

tccagactgc tgctcgaatc ttggcttctc ctgttgagtt ggctttggtt gtcatgaagg   1080

atcttagtca gaattttcct accaaagcca gagcaataac aaaaacagct gtgagctcag   1140

aacttagaac cgaagtggaa gagaatcaga agtatttcaa gggaacttta ggattacaac   1200

ctggagattc agccctcttc atcaatggac ttcacatgga tttagataca caggatatat   1260

tcagtctgtt tgatgtgttg aggaatgaag ctcgggtaat ggagggtctg catagattgg   1320

gaatagaagg cctttctctg cataatgttt tgaagctgaa catccagccc tctgaggcag   1380

actatgccgt agacatccgg agtcctgcta tttcatgggt caacaacctg gaggttgata   1440

gcagatataa ttcgtggcct tctagtttac aagagttgct tcgacccacc tttcctggtg   1500

ttattcggca gatcaggaaa aacttacata atatggtttt catagttgat cctgcacatg   1560

agaccacagc agagttgatg aacacagctg agatgttcct tagtaatcat ataccactaa   1620

gaattggttt tatctttgtg gttaatgact ctgaagatgt tgatgggatg caagatgctg   1680

gagtggctgt tcttagagca tataattatg ttgcccaaga agtggatgat tatcatgcct   1740

tccagactct gacacatatc tataacaagg tgaggactgg agaaaaagtg aaagttgaac   1800

atgtggtcag tgtcctggag aagaaatatc cgtatgtaga agtgaatagc attttgggga   1860

ttgattctgc ttatgatcgg aatcggaagg aagcaagagg ctactatgag cagactggag   1920

ttggacctct gcccgttgtg ctgttcaatg gaatgccctt tgaaagggaa cagctagacc   1980

ctgatgagtt agaaaccatc acaatgcata aaatcctgga gaccaccacc ttcttccaaa   2040

gagcggtgta cttgggtgaa ctgccccatg atcaagatgt ggtagagtat atcatgaatc   2100

agccaaatgt tgttccacga atcaattcta ggattttgac agctgaacga gactacctgg   2160

atttaacagc gagtaataac ttctttgtgg atgattatgc tagatttact atcttggatt   2220

cccaaggcaa gactgctgct gtagccaata gtatgaacta tctgacaaag aaaggaatgt   2280

cctccaagga aatctatgat gattctttta ttaggccagt aactttttgg attgttgggg   2340

attttgatag cccttctgga cggcagttac tgtatgatgc catcaaacat cagaaatcca   2400

gtaacaatgt tagaataagc atgatcaata atcctgccaa agagataagc tatgagaaca   2460

ctcagatctc cagagcaatc tgggcagctc tccaaactca gacttccaac gctgctaaga   2520

acttcatcac caaaatggcc aaggaggggg ctgcagaggc cctggctgca ggagctgaca   2580

ttgcggagtt ctctgttggg ggaatggatt tcagtctttt taaagaggtc tttgagtctt   2640

ccaaaatgga tttcattttg tctcatgccg tgtactgcag ggatgttctg aagctgaaga   2700

agggacagag ggcagtgatc agcaatggaa ggatcattgg gccactggag gatagtgagc   2760

tctttaatca agacgatttc cacctcctcg aaaatatcat cttaaaaacc tcaggacaga   2820

aaataaaatc tcatattcaa cagcttcggg tagaagaaga tgtggcaagc gacttggtaa   2880

tgaaggtgga tgctcttctg tcagcgcaac caaaaggaga tccaagaatc gagtaccagt   2940

tttttgaaga cagacacagt gcaatcaaac tgaggccgaa ggaaggggag acatactttg   3000

atgttgtggc tgtcgttgac cctgtcacca gagaagcaca gagacttgct cctttgctct   3060

tggttttggc tcagctgata aacatgaatc tgagagtatt tatgaactgc caatccaaac   3120

tttctgacat gcctttaaaa agcttttacc gttatgtctt agaaccagag atttctttca   3180

cttcagacaa tagttttgct aagggtccaa tcgcaaaatt tttggatatg cctcagtctc   3240

cactgttcac tctgaatttg aacacacctg agagctggat ggtagaatct gtcagaacac   3300

catatgatct tgataatatt tatttagaag aggtggacag tgtagtggct gctgagtatg   3360

agctggaata cctgttactg gaaggtcatt gctacgacat caccacaggc cagcctccac   3420

ggggactaca gtttacctta ggaacttcag ccaacccggt cattgtggac accattgtta   3480

tggccaatct gggctacttt cagctgaaag ccaacccagg agcttggatc ctcagactta   3540

ggaagggacg ctctgaagat atttatagaa tttacagcca cgatggcact gattctcccc   3600

ctgatgctga tgaggtggtt atcgtcctca acaacttcaa aagcaaaatt attaaagtga   3660

aggttcagaa gaaggcagat atggtgaacg aagacttgct gagtgatgga acgagtgaga   3720

atgaatctgg attttgggat tccttcaaat ggggctttac aggacagaag actgaggaag   3780

tgaagcaaga taaagatgac ataattaata ttttctccgt tgcatctggt catctctacg   3840

aaagatttct tcgcataatg atgctatccg tgctgaagaa taccaagact cctgtgaaat   3900

tctggttctt gaagaattac ttgtccccca catttaagga gtttatacct tacatggcaa   3960

atgaatacaa tttccagtat gagcttgttc agtacaaatg gccccggtgg cttcatcaac   4020

aaactgaaaa acagcgtatc atctggggtt acaagatcct cttcctggat gtacttttcc   4080

cactagttgt tgacaagttc ctgtttgtgg atgctgatca gattgtacga acagatctga   4140

aagagttaag agatttcaat ttggatggtg ctccttatgg ttacactcct ttctgtgaca   4200

gccgaagaga aatggacggc tacaggttct ggaagtcagg gtactgggcc agtcatttag   4260

ccgggcgaaa gtatcatatc agtgcactat atgttgtgga tctgaagaag tttaggaaaa   4320

tagctgctgg tgacagactc aggggacagt accaaggtct gagtcaggac cctaacagcc   4380

tttcaaatct tgatcaagat ctgcccaata acatgattca tcaggtgcca attaaatccc   4440

tccctcaaga atggctttgg tgtgaaacgt ggtgtgatga cgcctctaag aaaagggcaa   4500

aaaccattga tttgtgtaat aatccgatga ccaaagagcc gaaactggaa gcagctgtgc   4560

ggattgtccc ggagtggcag gactacgacc aagagatcaa acagctacag atccgctttc   4620

agaaggagaa agaaacggga gcactgtaca aagagaagac aaaagaacca agccgagaag   4680

gtcctcagaa acgtgaagaa ttatgatctc tggagaagga caggaaatca ccccatttga   4740

aaaacagttt ttataataaa tgctagtttt ttctgatctg tctatacaac tgctgataag   4800

ccggctgggc aggagtgcca caccttttga ttctgagcat ttgattctga cttctgtact   4860

ctggtggcca ctggatcttt gggattaaag ctctgttgga tttgtacctc agaggaagac   4920

caagtggctg atcctttgga ctctgtaaag agcattcttc tagtcagagg gtggaatggc   4980

agcagcaact ggaagaaaat gagttttttg gtgcccacac ccaagagcac acacatgctg   5040

cactgtctcg gaaagcaggg ccagctagag ccaccatgtt cttccttacc tcagtttacc   5100

tgcggcctgc gctgcactgc agatgcccac cctgccctgg gtctggccgg cggaagctct   5160

gtccaaggtc cacacacctc caggtttacg ccaacatcct tgtgccctcc ccaccttctc   5220

ttccaacgca ttaggtgcat tgtttaattg aaatccaacc aacaattgtg tgtcaaggct   5280

ggtttggtgc agtggctggg caaattaatt ttgggccagg atgggggtgg gttgcagtga   5340

gggtagggaa aatgtcagga gtaggaaggt tcgggggtta agggaaggga aggaagacca   5400

gaactggcca tcctctttta taatccatta gtagcaccat ggctcatttg aaatgaaaat   5460

attacactta ttccccaccc aaccgcagtg aactttctag gtaattgttt tgaaaacaat   5520

ttttgtatct gtgaaagtct ttgctttttc tttccacctt ctagaaaagt ctgctaccag   5580

tttccttact gaatacagcc atactcagcc cctctcgcat ccagcccgtc agggtcaggg   5640

tcagggtcag gctccctcaa gacgagcacc gcattgtctg ccctcttttg cgtaggattt   5700

ttctctcaga cccaggggac attgccttgg acttttctct acaaatgccc tcagatgtaa   5760

gaccagaaat gattctgctt gtggaactcg tggctttctg tcctattttc cttttatgtg   5820

agccctgcag gttgcctttg gcgcccacac cagttctgtc ttcatgtcgc tgcatcgtga   5880

agccccattt gcctttagtc cctgctttgt gtgtcttcac ttccacagcc agtgttgccc   5940

ctcagggcat actttgctgg tgaacgggct gtagagtctt gagtatgtta ttggcctaag   6000

tgggcatgag gccccagcat ccgactccat ctgccaggct gcagggcaca gcagcactgg   6060

catagacagg cacgctctgt cttccaacgt gcaccagcct tttcttacat attttgcctg   6120

tttttaaaaa atacgaggag agggtgcaga tggatactgt gccctcaccc tcctaagcca   6180

ggtaatatat tgatgtgcag acttttaaga aatcttagtc ttatcacaaa tatcaagtaa   6240

tttatttttt ccattttcaa atgcaaaagt tagcctagga agcctcccag tcatcctgaa   6300

ggaccttttg actttgcttt tataattctg ttaaaaattg aggaggggat taatgagtac   6360

aatgaaaaca aaacaaaaca aaaaa                                         6385


<210>  1480
<211>  1555
<212>  PRT
<213>  Homosapiens

<400>  1480

Met Gly Cys Lys Gly Asp Ala Ser Gly Ala Cys Ala Ala Gly Ala Leu 
1               5                   10                  15      


Pro Val Thr Gly Val Cys Tyr Lys Met Gly Val Leu Val Val Leu Thr 
            20                  25                  30          


Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp Ser Lys Ala Ile Thr 
        35                  40                  45              


Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro Leu Leu Leu Glu Ala 
    50                  55                  60                  


Ser Glu Phe Leu Ala Glu Asp Ser Gln Glu Lys Phe Trp Asn Phe Val 
65                  70                  75                  80  


Glu Ala Ser Gln Asn Ile Gly Ser Ser Asp His Asp Gly Thr Asp Tyr 
                85                  90                  95      


Ser Tyr Tyr His Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro 
            100                 105                 110         


Leu Gln Gln Asn Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser 
        115                 120                 125             


Ala Thr Ile Gln Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro 
    130                 135                 140                 


Glu Gly Cys Asn Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys Glu 
145                 150                 155                 160 


Ser Asp Thr Leu Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys 
                165                 170                 175     


Pro Leu Leu Phe Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro Glu 
            180                 185                 190         


Ser Pro Val Val Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser 
        195                 200                 205             


Asn Phe His Arg Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn 
    210                 215                 220                 


Tyr Val Phe Arg His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr 
225                 230                 235                 240 


Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys 
                245                 250                 255     


Ala Lys Asp Asp Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr Val 
            260                 265                 270         


Ile Gly Glu Asn Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe Gly 
        275                 280                 285             


Lys Leu Arg Asp Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu 
    290                 295                 300                 


Arg Lys His Leu Val Glu Ser Thr Asn Glu Met Ala Pro Leu Lys Val 
305                 310                 315                 320 


Trp Gln Leu Gln Asp Leu Ser Phe Gln Thr Ala Ala Arg Ile Leu Ala 
                325                 330                 335     


Ser Pro Val Glu Leu Ala Leu Val Val Met Lys Asp Leu Ser Gln Asn 
            340                 345                 350         


Phe Pro Thr Lys Ala Arg Ala Ile Thr Lys Thr Ala Val Ser Ser Glu 
        355                 360                 365             


Leu Arg Thr Glu Val Glu Glu Asn Gln Lys Tyr Phe Lys Gly Thr Leu 
    370                 375                 380                 


Gly Leu Gln Pro Gly Asp Ser Ala Leu Phe Ile Asn Gly Leu His Met 
385                 390                 395                 400 


Asp Leu Asp Thr Gln Asp Ile Phe Ser Leu Phe Asp Val Leu Arg Asn 
                405                 410                 415     


Glu Ala Arg Val Met Glu Gly Leu His Arg Leu Gly Ile Glu Gly Leu 
            420                 425                 430         


Ser Leu His Asn Val Leu Lys Leu Asn Ile Gln Pro Ser Glu Ala Asp 
        435                 440                 445             


Tyr Ala Val Asp Ile Arg Ser Pro Ala Ile Ser Trp Val Asn Asn Leu 
    450                 455                 460                 


Glu Val Asp Ser Arg Tyr Asn Ser Trp Pro Ser Ser Leu Gln Glu Leu 
465                 470                 475                 480 


Leu Arg Pro Thr Phe Pro Gly Val Ile Arg Gln Ile Arg Lys Asn Leu 
                485                 490                 495     


His Asn Met Val Phe Ile Val Asp Pro Ala His Glu Thr Thr Ala Glu 
            500                 505                 510         


Leu Met Asn Thr Ala Glu Met Phe Leu Ser Asn His Ile Pro Leu Arg 
        515                 520                 525             


Ile Gly Phe Ile Phe Val Val Asn Asp Ser Glu Asp Val Asp Gly Met 
    530                 535                 540                 


Gln Asp Ala Gly Val Ala Val Leu Arg Ala Tyr Asn Tyr Val Ala Gln 
545                 550                 555                 560 


Glu Val Asp Asp Tyr His Ala Phe Gln Thr Leu Thr His Ile Tyr Asn 
                565                 570                 575     


Lys Val Arg Thr Gly Glu Lys Val Lys Val Glu His Val Val Ser Val 
            580                 585                 590         


Leu Glu Lys Lys Tyr Pro Tyr Val Glu Val Asn Ser Ile Leu Gly Ile 
        595                 600                 605             


Asp Ser Ala Tyr Asp Arg Asn Arg Lys Glu Ala Arg Gly Tyr Tyr Glu 
    610                 615                 620                 


Gln Thr Gly Val Gly Pro Leu Pro Val Val Leu Phe Asn Gly Met Pro 
625                 630                 635                 640 


Phe Glu Arg Glu Gln Leu Asp Pro Asp Glu Leu Glu Thr Ile Thr Met 
                645                 650                 655     


His Lys Ile Leu Glu Thr Thr Thr Phe Phe Gln Arg Ala Val Tyr Leu 
            660                 665                 670         


Gly Glu Leu Pro His Asp Gln Asp Val Val Glu Tyr Ile Met Asn Gln 
        675                 680                 685             


Pro Asn Val Val Pro Arg Ile Asn Ser Arg Ile Leu Thr Ala Glu Arg 
    690                 695                 700                 


Asp Tyr Leu Asp Leu Thr Ala Ser Asn Asn Phe Phe Val Asp Asp Tyr 
705                 710                 715                 720 


Ala Arg Phe Thr Ile Leu Asp Ser Gln Gly Lys Thr Ala Ala Val Ala 
                725                 730                 735     


Asn Ser Met Asn Tyr Leu Thr Lys Lys Gly Met Ser Ser Lys Glu Ile 
            740                 745                 750         


Tyr Asp Asp Ser Phe Ile Arg Pro Val Thr Phe Trp Ile Val Gly Asp 
        755                 760                 765             


Phe Asp Ser Pro Ser Gly Arg Gln Leu Leu Tyr Asp Ala Ile Lys His 
    770                 775                 780                 


Gln Lys Ser Ser Asn Asn Val Arg Ile Ser Met Ile Asn Asn Pro Ala 
785                 790                 795                 800 


Lys Glu Ile Ser Tyr Glu Asn Thr Gln Ile Ser Arg Ala Ile Trp Ala 
                805                 810                 815     


Ala Leu Gln Thr Gln Thr Ser Asn Ala Ala Lys Asn Phe Ile Thr Lys 
            820                 825                 830         


Met Ala Lys Glu Gly Ala Ala Glu Ala Leu Ala Ala Gly Ala Asp Ile 
        835                 840                 845             


Ala Glu Phe Ser Val Gly Gly Met Asp Phe Ser Leu Phe Lys Glu Val 
    850                 855                 860                 


Phe Glu Ser Ser Lys Met Asp Phe Ile Leu Ser His Ala Val Tyr Cys 
865                 870                 875                 880 


Arg Asp Val Leu Lys Leu Lys Lys Gly Gln Arg Ala Val Ile Ser Asn 
                885                 890                 895     


Gly Arg Ile Ile Gly Pro Leu Glu Asp Ser Glu Leu Phe Asn Gln Asp 
            900                 905                 910         


Asp Phe His Leu Leu Glu Asn Ile Ile Leu Lys Thr Ser Gly Gln Lys 
        915                 920                 925             


Ile Lys Ser His Ile Gln Gln Leu Arg Val Glu Glu Asp Val Ala Ser 
    930                 935                 940                 


Asp Leu Val Met Lys Val Asp Ala Leu Leu Ser Ala Gln Pro Lys Gly 
945                 950                 955                 960 


Asp Pro Arg Ile Glu Tyr Gln Phe Phe Glu Asp Arg His Ser Ala Ile 
                965                 970                 975     


Lys Leu Arg Pro Lys Glu Gly Glu Thr Tyr Phe Asp Val Val Ala Val 
            980                 985                 990         


Val Asp Pro Val Thr Arg Glu Ala  Gln Arg Leu Ala Pro  Leu Leu Leu 
        995                 1000                 1005             


Val Leu  Ala Gln Leu Ile Asn  Met Asn Leu Arg Val  Phe Met Asn 
    1010                 1015                 1020             


Cys Gln  Ser Lys Leu Ser Asp  Met Pro Leu Lys Ser  Phe Tyr Arg 
    1025                 1030                 1035             


Tyr Val  Leu Glu Pro Glu Ile  Ser Phe Thr Ser Asp  Asn Ser Phe 
    1040                 1045                 1050             


Ala Lys  Gly Pro Ile Ala Lys  Phe Leu Asp Met Pro  Gln Ser Pro 
    1055                 1060                 1065             


Leu Phe  Thr Leu Asn Leu Asn  Thr Pro Glu Ser Trp  Met Val Glu 
    1070                 1075                 1080             


Ser Val  Arg Thr Pro Tyr Asp  Leu Asp Asn Ile Tyr  Leu Glu Glu 
    1085                 1090                 1095             


Val Asp  Ser Val Val Ala Ala  Glu Tyr Glu Leu Glu  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Glu  Gly His Cys Tyr Asp  Ile Thr Thr Gly Gln  Pro Pro Arg 
    1115                 1120                 1125             


Gly Leu  Gln Phe Thr Leu Gly  Thr Ser Ala Asn Pro  Val Ile Val 
    1130                 1135                 1140             


Asp Thr  Ile Val Met Ala Asn  Leu Gly Tyr Phe Gln  Leu Lys Ala 
    1145                 1150                 1155             


Asn Pro  Gly Ala Trp Ile Leu  Arg Leu Arg Lys Gly  Arg Ser Glu 
    1160                 1165                 1170             


Asp Ile  Tyr Arg Ile Tyr Ser  His Asp Gly Thr Asp  Ser Pro Pro 
    1175                 1180                 1185             


Asp Ala  Asp Glu Val Val Ile  Val Leu Asn Asn Phe  Lys Ser Lys 
    1190                 1195                 1200             


Ile Ile  Lys Val Lys Val Gln  Lys Lys Ala Asp Met  Val Asn Glu 
    1205                 1210                 1215             


Asp Leu  Leu Ser Asp Gly Thr  Ser Glu Asn Glu Ser  Gly Phe Trp 
    1220                 1225                 1230             


Asp Ser  Phe Lys Trp Gly Phe  Thr Gly Gln Lys Thr  Glu Glu Val 
    1235                 1240                 1245             


Lys Gln  Asp Lys Asp Asp Ile  Ile Asn Ile Phe Ser  Val Ala Ser 
    1250                 1255                 1260             


Gly His  Leu Tyr Glu Arg Phe  Leu Arg Ile Met Met  Leu Ser Val 
    1265                 1270                 1275             


Leu Lys  Asn Thr Lys Thr Pro  Val Lys Phe Trp Phe  Leu Lys Asn 
    1280                 1285                 1290             


Tyr Leu  Ser Pro Thr Phe Lys  Glu Phe Ile Pro Tyr  Met Ala Asn 
    1295                 1300                 1305             


Glu Tyr  Asn Phe Gln Tyr Glu  Leu Val Gln Tyr Lys  Trp Pro Arg 
    1310                 1315                 1320             


Trp Leu  His Gln Gln Thr Glu  Lys Gln Arg Ile Ile  Trp Gly Tyr 
    1325                 1330                 1335             


Lys Ile  Leu Phe Leu Asp Val  Leu Phe Pro Leu Val  Val Asp Lys 
    1340                 1345                 1350             


Phe Leu  Phe Val Asp Ala Asp  Gln Ile Val Arg Thr  Asp Leu Lys 
    1355                 1360                 1365             


Glu Leu  Arg Asp Phe Asn Leu  Asp Gly Ala Pro Tyr  Gly Tyr Thr 
    1370                 1375                 1380             


Pro Phe  Cys Asp Ser Arg Arg  Glu Met Asp Gly Tyr  Arg Phe Trp 
    1385                 1390                 1395             


Lys Ser  Gly Tyr Trp Ala Ser  His Leu Ala Gly Arg  Lys Tyr His 
    1400                 1405                 1410             


Ile Ser  Ala Leu Tyr Val Val  Asp Leu Lys Lys Phe  Arg Lys Ile 
    1415                 1420                 1425             


Ala Ala  Gly Asp Arg Leu Arg  Gly Gln Tyr Gln Gly  Leu Ser Gln 
    1430                 1435                 1440             


Asp Pro  Asn Ser Leu Ser Asn  Leu Asp Gln Asp Leu  Pro Asn Asn 
    1445                 1450                 1455             


Met Ile  His Gln Val Pro Ile  Lys Ser Leu Pro Gln  Glu Trp Leu 
    1460                 1465                 1470             


Trp Cys  Glu Thr Trp Cys Asp  Asp Ala Ser Lys Lys  Arg Ala Lys 
    1475                 1480                 1485             


Thr Ile  Asp Leu Cys Asn Asn  Pro Met Thr Lys Glu  Pro Lys Leu 
    1490                 1495                 1500             


Glu Ala  Ala Val Arg Ile Val  Pro Glu Trp Gln Asp  Tyr Asp Gln 
    1505                 1510                 1515             


Glu Ile  Lys Gln Leu Gln Ile  Arg Phe Gln Lys Glu  Lys Glu Thr 
    1520                 1525                 1530             


Gly Ala  Leu Tyr Lys Glu Lys  Thr Lys Glu Pro Ser  Arg Glu Gly 
    1535                 1540                 1545             


Pro Gln  Lys Arg Glu Glu Leu  
    1550                 1555 


<210>  1481
<211>  6675
<212>  DNA
<213>  Homosapiens

<400>  1481
tgctttgcga ggctgggtgt tgagtcgagc cgcgggaaag gcgcgtgtcg gcctctcact     60

ggcgcagcct gcactgccgc tgccgcctcg ccccgccctg ccctggcgtt gtctctggca    120

ctgtggcgga ctgaccacgg cccgggcatg ggctgcaagg gagacgcgag cggtgcgtgt    180

gccgcgggtg cgctgccggt gacaggtacc caggggtggc gtgaggaggc ctcgtggaca    240

aagagagggt ttggggcaca aggcgaccct gtgcccctgt cacattgagc ttccgcctct    300

accgtgactc agtttaccct ctggtgtcct atcccttccc ctattcgcga gcgccccgag    360

ttgccctcag tggtcttctt ggcaaggagt ttgctataaa atgggagttc tggttgtact    420

cactgttctg tggctgttct cctcagtaaa ggccgactca aaagccatta caacctctct    480

tacaacaaaa tggttttcca ctccattgtt gttagaagcc agtgagtttt tagcagaaga    540

cagtcaagag aaattttgga attttgtaga agccagtcaa aatattggat catcagatca    600

tgacggtacc gattattcct actatcatgc aatattggag gctgcatttc agtttctgtc    660

acccctccag cagaatttgt ttaaattttg tctgtccctt cgttcttact cagctacaat    720

ccaagccttc cagcagatag cagctgatga acctccacca gaaggatgta attcgttttt    780

ttcagtgcat ggaaagaaga cttgtgaatc tgataccctt gaggctcttc tactgacagc    840

ctctgaaaga cccaaacctt tattgttcaa aggagatcac agatatccct cgtctaatcc    900

tgaaagccct gtggtgattt tctactctga gattggctct gaggaatttt ccaattttca    960

ccgccagctt atatcaaaaa gcaatgcagg caaaatcaat tatgtattca gacattatat   1020

atttaatccc aggaaggagc ctgtttacct ctctggctat ggcgtggaat tggccattaa   1080

gagcactgag tacaaggcca aggatgatac tcaggtgaaa ggaactgagg taaacaccac   1140

agtgattggt gaaaatgatc ctattgatga ggttcagggg ttcctctttg gaaaattaag   1200

agatctgcac cccgacctgg agggacagtt gaaagaactc agaaagcatc ttgtagagag   1260

caccaatgaa atggcacctt taaaggtttg gcagttgcaa gatctcagtt tccagactgc   1320

tgctcgaatc ttggcttctc ctgttgagtt ggctttggtt gtcatgaagg atcttagtca   1380

gaattttcct accaaagcca gagcaataac aaaaacagct gtgagctcag aacttagaac   1440

cgaagtggaa gagaatcaga agtatttcaa gggaacttta ggattacaac ctggagattc   1500

agccctcttc atcaatggac ttcacatgga tttagataca caggatatat tcagtctgtt   1560

tgatgtgttg aggaatgaag ctcgggtaat ggagggtctg catagattgg gaatagaagg   1620

cctttctctg cataatgttt tgaagctgaa catccagccc tctgaggcag actatgccgt   1680

agacatccgg agtcctgcta tttcatgggt caacaacctg gaggttgata gcagatataa   1740

ttcgtggcct tctagtttac aagagttgct tcgacccacc tttcctggtg ttattcggca   1800

gatcaggaaa aacttacata atatggtttt catagttgat cctgcacatg agaccacagc   1860

agagttgatg aacacagctg agatgttcct tagtaatcat ataccactaa gaattggttt   1920

tatctttgtg gttaatgact ctgaagatgt tgatgggatg caagatgctg gagtggctgt   1980

tcttagagca tataattatg ttgcccaaga agtggatgat tatcatgcct tccagactct   2040

gacacatatc tataacaagg tgaggactgg agaaaaagtg aaagttgaac atgtggtcag   2100

tgtcctggag aagaaatatc cgtatgtaga agtgaatagc attttgggga ttgattctgc   2160

ttatgatcgg aatcggaagg aagcaagagg ctactatgag cagactggag ttggacctct   2220

gcccgttgtg ctgttcaatg gaatgccctt tgaaagggaa cagctagacc ctgatgagtt   2280

agaaaccatc acaatgcata aaatcctgga gaccaccacc ttcttccaaa gagcggtgta   2340

cttgggtgaa ctgccccatg atcaagatgt ggtagagtat atcatgaatc agccaaatgt   2400

tgttccacga atcaattcta ggattttgac agctgaacga gactacctgg atttaacagc   2460

gagtaataac ttctttgtgg atgattatgc tagatttact atcttggatt cccaaggcaa   2520

gactgctgct gtagccaata gtatgaacta tctgacaaag aaaggaatgt cctccaagga   2580

aatctatgat gattctttta ttaggccagt aactttttgg attgttgggg attttgatag   2640

cccttctgga cggcagttac tgtatgatgc catcaaacat cagaaatcca gtaacaatgt   2700

tagaataagc atgatcaata atcctgccaa agagataagc tatgagaaca ctcagatctc   2760

cagagcaatc tgggcagctc tccaaactca gacttccaac gctgctaaga acttcatcac   2820

caaaatggcc aaggaggggg ctgcagaggc cctggctgca ggagctgaca ttgcggagtt   2880

ctctgttggg ggaatggatt tcagtctttt taaagaggtc tttgagtctt ccaaaatgga   2940

tttcattttg tctcatgccg tgtactgcag ggatgttctg aagctgaaga agggacagag   3000

ggcagtgatc agcaatggaa ggatcattgg gccactggag gatagtgagc tctttaatca   3060

agacgatttc cacctcctcg aaaatatcat cttaaaaacc tcaggacaga aaataaaatc   3120

tcatattcaa cagcttcggg tagaagaaga tgtggcaagc gacttggtaa tgaaggtgga   3180

tgctcttctg tcagcgcaac caaaaggaga tccaagaatc gagtaccagt tttttgaaga   3240

cagacacagt gcaatcaaac tgaggccgaa ggaaggggag acatactttg atgttgtggc   3300

tgtcgttgac cctgtcacca gagaagcaca gagacttgct cctttgctct tggttttggc   3360

tcagctgata aacatgaatc tgagagtatt tatgaactgc caatccaaac tttctgacat   3420

gcctttaaaa agcttttacc gttatgtctt agaaccagag atttctttca cttcagacaa   3480

tagttttgct aagggtccaa tcgcaaaatt tttggatatg cctcagtctc cactgttcac   3540

tctgaatttg aacacacctg agagctggat ggtagaatct gtcagaacac catatgatct   3600

tgataatatt tatttagaag aggtggacag tgtagtggct gctgagtatg agctggaata   3660

cctgttactg gaaggtcatt gctacgacat caccacaggc cagcctccac ggggactaca   3720

gtttacctta ggaacttcag ccaacccggt cattgtggac accattgtta tggccaatct   3780

gggctacttt cagctgaaag ccaacccagg agcttggatc ctcagactta ggaagggacg   3840

ctctgaagat atttatagaa tttacagcca cgatggcact gattctcccc ctgatgctga   3900

tgaggtggtt atcgtcctca acaacttcaa aagcaaaatt attaaagtga aggttcagaa   3960

gaaggcagat atggtgaacg aagacttgct gagtgatgga acgagtgaga atgaatctgg   4020

attttgggat tccttcaaat ggggctttac aggacagaag actgaggaag tgaagcaaga   4080

taaagatgac ataattaata ttttctccgt tgcatctggt catctctacg aaagatttct   4140

tcgcataatg atgctatccg tgctgaagaa taccaagact cctgtgaaat tctggttctt   4200

gaagaattac ttgtccccca catttaagga gtttatacct tacatggcaa atgaatacaa   4260

tttccagtat gagcttgttc agtacaaatg gccccggtgg cttcatcaac aaactgaaaa   4320

acagcgtatc atctggggtt acaagatcct cttcctggat gtacttttcc cactagttgt   4380

tgacaagttc ctgtttgtgg atgctgatca gattgtacga acagatctga aagagttaag   4440

agatttcaat ttggatggtg ctccttatgg ttacactcct ttctgtgaca gccgaagaga   4500

aatggacggc tacaggttct ggaagtcagg gtactgggcc agtcatttag ccgggcgaaa   4560

gtatcatatc agtgcactat atgttgtgga tctgaagaag tttaggaaaa tagctgctgg   4620

tgacagactc aggggacagt accaaggtct gagtcaggac cctaacagcc tttcaaatct   4680

tgatcaagat ctgcccaata acatgattca tcaggtgcca attaaatccc tccctcaaga   4740

atggctttgg tgtgaaacgt ggtgtgatga cgcctctaag aaaagggcaa aaaccattga   4800

tttgtgtaat aatccgatga ccaaagagcc gaaactggaa gcagctgtgc ggattgtccc   4860

ggagtggcag gactacgacc aagagatcaa acagctacag atccgctttc agaaggagaa   4920

agaaacggga gcactgtaca aagagaagac aaaagaacca agccgagaag gtcctcagaa   4980

acgtgaagaa ttatgatctc tggagaagga caggaaatca ccccatttga aaaacagttt   5040

ttataataaa tgctagtttt ttctgatctg tctatacaac tgctgataag ccggctgggc   5100

aggagtgcca caccttttga ttctgagcat ttgattctga cttctgtact ctggtggcca   5160

ctggatcttt gggattaaag ctctgttgga tttgtacctc agaggaagac caagtggctg   5220

atcctttgga ctctgtaaag agcattcttc tagtcagagg gtggaatggc agcagcaact   5280

ggaagaaaat gagttttttg gtgcccacac ccaagagcac acacatgctg cactgtctcg   5340

gaaagcaggg ccagctagag ccaccatgtt cttccttacc tcagtttacc tgcggcctgc   5400

gctgcactgc agatgcccac cctgccctgg gtctggccgg cggaagctct gtccaaggtc   5460

cacacacctc caggtttacg ccaacatcct tgtgccctcc ccaccttctc ttccaacgca   5520

ttaggtgcat tgtttaattg aaatccaacc aacaattgtg tgtcaaggct ggtttggtgc   5580

agtggctggg caaattaatt ttgggccagg atgggggtgg gttgcagtga gggtagggaa   5640

aatgtcagga gtaggaaggt tcgggggtta agggaaggga aggaagacca gaactggcca   5700

tcctctttta taatccatta gtagcaccat ggctcatttg aaatgaaaat attacactta   5760

ttccccaccc aaccgcagtg aactttctag gtaattgttt tgaaaacaat ttttgtatct   5820

gtgaaagtct ttgctttttc tttccacctt ctagaaaagt ctgctaccag tttccttact   5880

gaatacagcc atactcagcc cctctcgcat ccagcccgtc agggtcaggg tcagggtcag   5940

gctccctcaa gacgagcacc gcattgtctg ccctcttttg cgtaggattt ttctctcaga   6000

cccaggggac attgccttgg acttttctct acaaatgccc tcagatgtaa gaccagaaat   6060

gattctgctt gtggaactcg tggctttctg tcctattttc cttttatgtg agccctgcag   6120

gttgcctttg gcgcccacac cagttctgtc ttcatgtcgc tgcatcgtga agccccattt   6180

gcctttagtc cctgctttgt gtgtcttcac ttccacagcc agtgttgccc ctcagggcat   6240

actttgctgg tgaacgggct gtagagtctt gagtatgtta ttggcctaag tgggcatgag   6300

gccccagcat ccgactccat ctgccaggct gcagggcaca gcagcactgg catagacagg   6360

cacgctctgt cttccaacgt gcaccagcct tttcttacat attttgcctg tttttaaaaa   6420

atacgaggag agggtgcaga tggatactgt gccctcaccc tcctaagcca ggtaatatat   6480

tgatgtgcag acttttaaga aatcttagtc ttatcacaaa tatcaagtaa tttatttttt   6540

ccattttcaa atgcaaaagt tagcctagga agcctcccag tcatcctgaa ggaccttttg   6600

actttgcttt tataattctg ttaaaaattg aggaggggat taatgagtac aatgaaaaca   6660

aaacaaaaca aaaaa                                                    6675


<210>  1482
<211>  1531
<212>  PRT
<213>  Homosapiens

<400>  1482

Met Gly Val Leu Val Val Leu Thr Val Leu Trp Leu Phe Ser Ser Val 
1               5                   10                  15      


Lys Ala Asp Ser Lys Ala Ile Thr Thr Ser Leu Thr Thr Lys Trp Phe 
            20                  25                  30          


Ser Thr Pro Leu Leu Leu Glu Ala Ser Glu Phe Leu Ala Glu Asp Ser 
        35                  40                  45              


Gln Glu Lys Phe Trp Asn Phe Val Glu Ala Ser Gln Asn Ile Gly Ser 
    50                  55                  60                  


Ser Asp His Asp Gly Thr Asp Tyr Ser Tyr Tyr His Ala Ile Leu Glu 
65                  70                  75                  80  


Ala Ala Phe Gln Phe Leu Ser Pro Leu Gln Gln Asn Leu Phe Lys Phe 
                85                  90                  95      


Cys Leu Ser Leu Arg Ser Tyr Ser Ala Thr Ile Gln Ala Phe Gln Gln 
            100                 105                 110         


Ile Ala Ala Asp Glu Pro Pro Pro Glu Gly Cys Asn Ser Phe Phe Ser 
        115                 120                 125             


Val His Gly Lys Lys Thr Cys Glu Ser Asp Thr Leu Glu Ala Leu Leu 
    130                 135                 140                 


Leu Thr Ala Ser Glu Arg Pro Lys Pro Leu Leu Phe Lys Gly Asp His 
145                 150                 155                 160 


Arg Tyr Pro Ser Ser Asn Pro Glu Ser Pro Val Val Ile Phe Tyr Ser 
                165                 170                 175     


Glu Ile Gly Ser Glu Glu Phe Ser Asn Phe His Arg Gln Leu Ile Ser 
            180                 185                 190         


Lys Ser Asn Ala Gly Lys Ile Asn Tyr Val Phe Arg His Tyr Ile Phe 
        195                 200                 205             


Asn Pro Arg Lys Glu Pro Val Tyr Leu Ser Gly Tyr Gly Val Glu Leu 
    210                 215                 220                 


Ala Ile Lys Ser Thr Glu Tyr Lys Ala Lys Asp Asp Thr Gln Val Lys 
225                 230                 235                 240 


Gly Thr Glu Val Asn Thr Thr Val Ile Gly Glu Asn Asp Pro Ile Asp 
                245                 250                 255     


Glu Val Gln Gly Phe Leu Phe Gly Lys Leu Arg Asp Leu His Pro Asp 
            260                 265                 270         


Leu Glu Gly Gln Leu Lys Glu Leu Arg Lys His Leu Val Glu Ser Thr 
        275                 280                 285             


Asn Glu Met Ala Pro Leu Lys Val Trp Gln Leu Gln Asp Leu Ser Phe 
    290                 295                 300                 


Gln Thr Ala Ala Arg Ile Leu Ala Ser Pro Val Glu Leu Ala Leu Val 
305                 310                 315                 320 


Val Met Lys Asp Leu Ser Gln Asn Phe Pro Thr Lys Ala Arg Ala Ile 
                325                 330                 335     


Thr Lys Thr Ala Val Ser Ser Glu Leu Arg Thr Glu Val Glu Glu Asn 
            340                 345                 350         


Gln Lys Tyr Phe Lys Gly Thr Leu Gly Leu Gln Pro Gly Asp Ser Ala 
        355                 360                 365             


Leu Phe Ile Asn Gly Leu His Met Asp Leu Asp Thr Gln Asp Ile Phe 
    370                 375                 380                 


Ser Leu Phe Asp Val Leu Arg Asn Glu Ala Arg Val Met Glu Gly Leu 
385                 390                 395                 400 


His Arg Leu Gly Ile Glu Gly Leu Ser Leu His Asn Val Leu Lys Leu 
                405                 410                 415     


Asn Ile Gln Pro Ser Glu Ala Asp Tyr Ala Val Asp Ile Arg Ser Pro 
            420                 425                 430         


Ala Ile Ser Trp Val Asn Asn Leu Glu Val Asp Ser Arg Tyr Asn Ser 
        435                 440                 445             


Trp Pro Ser Ser Leu Gln Glu Leu Leu Arg Pro Thr Phe Pro Gly Val 
    450                 455                 460                 


Ile Arg Gln Ile Arg Lys Asn Leu His Asn Met Val Phe Ile Val Asp 
465                 470                 475                 480 


Pro Ala His Glu Thr Thr Ala Glu Leu Met Asn Thr Ala Glu Met Phe 
                485                 490                 495     


Leu Ser Asn His Ile Pro Leu Arg Ile Gly Phe Ile Phe Val Val Asn 
            500                 505                 510         


Asp Ser Glu Asp Val Asp Gly Met Gln Asp Ala Gly Val Ala Val Leu 
        515                 520                 525             


Arg Ala Tyr Asn Tyr Val Ala Gln Glu Val Asp Asp Tyr His Ala Phe 
    530                 535                 540                 


Gln Thr Leu Thr His Ile Tyr Asn Lys Val Arg Thr Gly Glu Lys Val 
545                 550                 555                 560 


Lys Val Glu His Val Val Ser Val Leu Glu Lys Lys Tyr Pro Tyr Val 
                565                 570                 575     


Glu Val Asn Ser Ile Leu Gly Ile Asp Ser Ala Tyr Asp Arg Asn Arg 
            580                 585                 590         


Lys Glu Ala Arg Gly Tyr Tyr Glu Gln Thr Gly Val Gly Pro Leu Pro 
        595                 600                 605             


Val Val Leu Phe Asn Gly Met Pro Phe Glu Arg Glu Gln Leu Asp Pro 
    610                 615                 620                 


Asp Glu Leu Glu Thr Ile Thr Met His Lys Ile Leu Glu Thr Thr Thr 
625                 630                 635                 640 


Phe Phe Gln Arg Ala Val Tyr Leu Gly Glu Leu Pro His Asp Gln Asp 
                645                 650                 655     


Val Val Glu Tyr Ile Met Asn Gln Pro Asn Val Val Pro Arg Ile Asn 
            660                 665                 670         


Ser Arg Ile Leu Thr Ala Glu Arg Asp Tyr Leu Asp Leu Thr Ala Ser 
        675                 680                 685             


Asn Asn Phe Phe Val Asp Asp Tyr Ala Arg Phe Thr Ile Leu Asp Ser 
    690                 695                 700                 


Gln Gly Lys Thr Ala Ala Val Ala Asn Ser Met Asn Tyr Leu Thr Lys 
705                 710                 715                 720 


Lys Gly Met Ser Ser Lys Glu Ile Tyr Asp Asp Ser Phe Ile Arg Pro 
                725                 730                 735     


Val Thr Phe Trp Ile Val Gly Asp Phe Asp Ser Pro Ser Gly Arg Gln 
            740                 745                 750         


Leu Leu Tyr Asp Ala Ile Lys His Gln Lys Ser Ser Asn Asn Val Arg 
        755                 760                 765             


Ile Ser Met Ile Asn Asn Pro Ala Lys Glu Ile Ser Tyr Glu Asn Thr 
    770                 775                 780                 


Gln Ile Ser Arg Ala Ile Trp Ala Ala Leu Gln Thr Gln Thr Ser Asn 
785                 790                 795                 800 


Ala Ala Lys Asn Phe Ile Thr Lys Met Ala Lys Glu Gly Ala Ala Glu 
                805                 810                 815     


Ala Leu Ala Ala Gly Ala Asp Ile Ala Glu Phe Ser Val Gly Gly Met 
            820                 825                 830         


Asp Phe Ser Leu Phe Lys Glu Val Phe Glu Ser Ser Lys Met Asp Phe 
        835                 840                 845             


Ile Leu Ser His Ala Val Tyr Cys Arg Asp Val Leu Lys Leu Lys Lys 
    850                 855                 860                 


Gly Gln Arg Ala Val Ile Ser Asn Gly Arg Ile Ile Gly Pro Leu Glu 
865                 870                 875                 880 


Asp Ser Glu Leu Phe Asn Gln Asp Asp Phe His Leu Leu Glu Asn Ile 
                885                 890                 895     


Ile Leu Lys Thr Ser Gly Gln Lys Ile Lys Ser His Ile Gln Gln Leu 
            900                 905                 910         


Arg Val Glu Glu Asp Val Ala Ser Asp Leu Val Met Lys Val Asp Ala 
        915                 920                 925             


Leu Leu Ser Ala Gln Pro Lys Gly Asp Pro Arg Ile Glu Tyr Gln Phe 
    930                 935                 940                 


Phe Glu Asp Arg His Ser Ala Ile Lys Leu Arg Pro Lys Glu Gly Glu 
945                 950                 955                 960 


Thr Tyr Phe Asp Val Val Ala Val Val Asp Pro Val Thr Arg Glu Ala 
                965                 970                 975     


Gln Arg Leu Ala Pro Leu Leu Leu Val Leu Ala Gln Leu Ile Asn Met 
            980                 985                 990         


Asn Leu Arg Val Phe Met Asn Cys  Gln Ser Lys Leu Ser  Asp Met Pro 
        995                 1000                 1005             


Leu Lys  Ser Phe Tyr Arg Tyr  Val Leu Glu Pro Glu  Ile Ser Phe 
    1010                 1015                 1020             


Thr Ser  Asp Asn Ser Phe Ala  Lys Gly Pro Ile Ala  Lys Phe Leu 
    1025                 1030                 1035             


Asp Met  Pro Gln Ser Pro Leu  Phe Thr Leu Asn Leu  Asn Thr Pro 
    1040                 1045                 1050             


Glu Ser  Trp Met Val Glu Ser  Val Arg Thr Pro Tyr  Asp Leu Asp 
    1055                 1060                 1065             


Asn Ile  Tyr Leu Glu Glu Val  Asp Ser Val Val Ala  Ala Glu Tyr 
    1070                 1075                 1080             


Glu Leu  Glu Tyr Leu Leu Leu  Glu Gly His Cys Tyr  Asp Ile Thr 
    1085                 1090                 1095             


Thr Gly  Gln Pro Pro Arg Gly  Leu Gln Phe Thr Leu  Gly Thr Ser 
    1100                 1105                 1110             


Ala Asn  Pro Val Ile Val Asp  Thr Ile Val Met Ala  Asn Leu Gly 
    1115                 1120                 1125             


Tyr Phe  Gln Leu Lys Ala Asn  Pro Gly Ala Trp Ile  Leu Arg Leu 
    1130                 1135                 1140             


Arg Lys  Gly Arg Ser Glu Asp  Ile Tyr Arg Ile Tyr  Ser His Asp 
    1145                 1150                 1155             


Gly Thr  Asp Ser Pro Pro Asp  Ala Asp Glu Val Val  Ile Val Leu 
    1160                 1165                 1170             


Asn Asn  Phe Lys Ser Lys Ile  Ile Lys Val Lys Val  Gln Lys Lys 
    1175                 1180                 1185             


Ala Asp  Met Val Asn Glu Asp  Leu Leu Ser Asp Gly  Thr Ser Glu 
    1190                 1195                 1200             


Asn Glu  Ser Gly Phe Trp Asp  Ser Phe Lys Trp Gly  Phe Thr Gly 
    1205                 1210                 1215             


Gln Lys  Thr Glu Glu Val Lys  Gln Asp Lys Asp Asp  Ile Ile Asn 
    1220                 1225                 1230             


Ile Phe  Ser Val Ala Ser Gly  His Leu Tyr Glu Arg  Phe Leu Arg 
    1235                 1240                 1245             


Ile Met  Met Leu Ser Val Leu  Lys Asn Thr Lys Thr  Pro Val Lys 
    1250                 1255                 1260             


Phe Trp  Phe Leu Lys Asn Tyr  Leu Ser Pro Thr Phe  Lys Glu Phe 
    1265                 1270                 1275             


Ile Pro  Tyr Met Ala Asn Glu  Tyr Asn Phe Gln Tyr  Glu Leu Val 
    1280                 1285                 1290             


Gln Tyr  Lys Trp Pro Arg Trp  Leu His Gln Gln Thr  Glu Lys Gln 
    1295                 1300                 1305             


Arg Ile  Ile Trp Gly Tyr Lys  Ile Leu Phe Leu Asp  Val Leu Phe 
    1310                 1315                 1320             


Pro Leu  Val Val Asp Lys Phe  Leu Phe Val Asp Ala  Asp Gln Ile 
    1325                 1330                 1335             


Val Arg  Thr Asp Leu Lys Glu  Leu Arg Asp Phe Asn  Leu Asp Gly 
    1340                 1345                 1350             


Ala Pro  Tyr Gly Tyr Thr Pro  Phe Cys Asp Ser Arg  Arg Glu Met 
    1355                 1360                 1365             


Asp Gly  Tyr Arg Phe Trp Lys  Ser Gly Tyr Trp Ala  Ser His Leu 
    1370                 1375                 1380             


Ala Gly  Arg Lys Tyr His Ile  Ser Ala Leu Tyr Val  Val Asp Leu 
    1385                 1390                 1395             


Lys Lys  Phe Arg Lys Ile Ala  Ala Gly Asp Arg Leu  Arg Gly Gln 
    1400                 1405                 1410             


Tyr Gln  Gly Leu Ser Gln Asp  Pro Asn Ser Leu Ser  Asn Leu Asp 
    1415                 1420                 1425             


Gln Asp  Leu Pro Asn Asn Met  Ile His Gln Val Pro  Ile Lys Ser 
    1430                 1435                 1440             


Leu Pro  Gln Glu Trp Leu Trp  Cys Glu Thr Trp Cys  Asp Asp Ala 
    1445                 1450                 1455             


Ser Lys  Lys Arg Ala Lys Thr  Ile Asp Leu Cys Asn  Asn Pro Met 
    1460                 1465                 1470             


Thr Lys  Glu Pro Lys Leu Glu  Ala Ala Val Arg Ile  Val Pro Glu 
    1475                 1480                 1485             


Trp Gln  Asp Tyr Asp Gln Glu  Ile Lys Gln Leu Gln  Ile Arg Phe 
    1490                 1495                 1500             


Gln Lys  Glu Lys Glu Thr Gly  Ala Leu Tyr Lys Glu  Lys Thr Lys 
    1505                 1510                 1515             


Glu Pro  Ser Arg Glu Gly Pro  Gln Lys Arg Glu Glu  Leu 
    1520                 1525                 1530     


<210>  1483
<211>  2051
<212>  DNA
<213>  Homosapiens

<400>  1483
cggcgccgag tagccgggcc gggccggagc gcgggcgcgg cggaggcagc tgcgcccggc     60

tcctcccctc ccaggccccg ccccccgccc gggccccggc gatggtgaca catgcggcgg    120

cggccgcgcg gcaggaccat ggttgagcgc gccagcaagt tcgtgctggt ggtggcgggc    180

tcggtgtgct tcatgctcat cttgtaccag tacgcgggcc caggactgag cctgggcgcg    240

cccggcggcc gcgcgccgcc cgacgacctg tacctgttcc ccacgcccga cccccactac    300

gagaagaagt actacttccc ggtccgcgag ctggagcgct cgctgcgctt cgacatgaag    360

ggcgacgacg tgatcgtctt cctgcacatc cagaagacgg gcggcaccac cttcggccgc    420

cacctcgtgc agaacgtacg cctcgaggtg ccgtgcgact gccggcccgg ccagaagaag    480

tgcacctgct accggcccaa ccgccgcgag acttggctct tctcccgctt ctccaccggc    540

tggagctgcg ggctgcacgc cgactggacc gagctcacca actgcgtgcc cggcgtgctg    600

gaccgccgcg actccgccgc gctgcgcacg cccaggaagt tctactacat caccctgcta    660

cgagaccccg tgtcccgcta cctgagcgag tggcggcatg tgcagagggg tgccacgtgg    720

aagacgtctt tgcatatgtg tgatgggcgc acgcccacgc ctgaggagct gccgccctgc    780

tacgagggca cggactggtc gggctgcacg ctacaggagt tcatggactg cccgtacaac    840

ctggccaaca accgccaggt gcgcatgctg gccgacctga gcctggtggg ctgctacaac    900

ctgtccttca tccccgaggg caagcgggcc cagctgctgc tcgagagcgc caagaagaac    960

ctgcggggca tggccttctt cggcctgacc gagttccagc gcaagacgca gtacctgttc   1020

gagcggacgt tcaacctcaa gttcatccgg cccttcatgc agtacaatag cacgcgggcg   1080

ggcggcgtgg aggtggatga agacaccatc cggcgcatcg aggagctcaa cgacctggac   1140

atgcagctgt acgactacgc caaggacctc ttccagcagc gctaccagta caagcggcag   1200

ctggagcgca gggagcagcg cctgaggagc cgcgaggagc gtctgctgca ccgggccaag   1260

gaggcactgc cgcgggagga tgccgacgag ccgggccgcg tgcccaccga ggactacatg   1320

agccacatca ttgagaagtg gtagtggcgg tggtggccac ggggaggcct cttggggggt   1380

gtgggggata aaacaggaca gacgacaggt ccacccaaga ctgtcaaggg atgagcatcc   1440

caaacctgct ccacagaggt agctgcgtcc tgaaaaaaaa cagagcaggg atgtagtggg   1500

gctgggcagg gatgggggct tgagaaatca acaggtgcag cccagtgggt cagaggaaag   1560

cgtgctcgaa ggatgccatg gtcagggcag ggcctccaga gcaggtgttg tgcctggagc   1620

tgctctcctg gcctccttgg atttatcgca aaaactgaag gtttgcgcaa gagacgagga   1680

cagcggaaag tggacctgcc aggccgggag tgtgtccctc accaactatg cacacagcac   1740

tcgctcttaa ctcctctgtc cgggctacta ggagtgagac cagcttctgg caactgcccc   1800

agctccaggc catcccatag cccctcctct tctggctgcc cccaatgccc cgaggcctgg   1860

ggagccccca gctcacccat ctgtagctcc ctcaaagtca gggcccaccc catctgaggc   1920

agagaagact cgagtccagc ccccaggaag cctgctcccc tctctggccc atggtcctgc   1980

ttcatgcttt gggtcaggag gccaaagctg atgttcaggc cccacccact ccctacagtc   2040

ctcagacccc g                                                        2051


<210>  1484
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  1484

Met Val Glu Arg Ala Ser Lys Phe Val Leu Val Val Ala Gly Ser Val 
1               5                   10                  15      


Cys Phe Met Leu Ile Leu Tyr Gln Tyr Ala Gly Pro Gly Leu Ser Leu 
            20                  25                  30          


Gly Ala Pro Gly Gly Arg Ala Pro Pro Asp Asp Leu Tyr Leu Phe Pro 
        35                  40                  45              


Thr Pro Asp Pro His Tyr Glu Lys Lys Tyr Tyr Phe Pro Val Arg Glu 
    50                  55                  60                  


Leu Glu Arg Ser Leu Arg Phe Asp Met Lys Gly Asp Asp Val Ile Val 
65                  70                  75                  80  


Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr Phe Gly Arg His Leu 
                85                  90                  95      


Val Gln Asn Val Arg Leu Glu Val Pro Cys Asp Cys Arg Pro Gly Gln 
            100                 105                 110         


Lys Lys Cys Thr Cys Tyr Arg Pro Asn Arg Arg Glu Thr Trp Leu Phe 
        115                 120                 125             


Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu His Ala Asp Trp Thr 
    130                 135                 140                 


Glu Leu Thr Asn Cys Val Pro Gly Val Leu Asp Arg Arg Asp Ser Ala 
145                 150                 155                 160 


Ala Leu Arg Thr Pro Arg Lys Phe Tyr Tyr Ile Thr Leu Leu Arg Asp 
                165                 170                 175     


Pro Val Ser Arg Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala 
            180                 185                 190         


Thr Trp Lys Thr Ser Leu His Met Cys Asp Gly Arg Thr Pro Thr Pro 
        195                 200                 205             


Glu Glu Leu Pro Pro Cys Tyr Glu Gly Thr Asp Trp Ser Gly Cys Thr 
    210                 215                 220                 


Leu Gln Glu Phe Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln 
225                 230                 235                 240 


Val Arg Met Leu Ala Asp Leu Ser Leu Val Gly Cys Tyr Asn Leu Ser 
                245                 250                 255     


Phe Ile Pro Glu Gly Lys Arg Ala Gln Leu Leu Leu Glu Ser Ala Lys 
            260                 265                 270         


Lys Asn Leu Arg Gly Met Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg 
        275                 280                 285             


Lys Thr Gln Tyr Leu Phe Glu Arg Thr Phe Asn Leu Lys Phe Ile Arg 
    290                 295                 300                 


Pro Phe Met Gln Tyr Asn Ser Thr Arg Ala Gly Gly Val Glu Val Asp 
305                 310                 315                 320 


Glu Asp Thr Ile Arg Arg Ile Glu Glu Leu Asn Asp Leu Asp Met Gln 
                325                 330                 335     


Leu Tyr Asp Tyr Ala Lys Asp Leu Phe Gln Gln Arg Tyr Gln Tyr Lys 
            340                 345                 350         


Arg Gln Leu Glu Arg Arg Glu Gln Arg Leu Arg Ser Arg Glu Glu Arg 
        355                 360                 365             


Leu Leu His Arg Ala Lys Glu Ala Leu Pro Arg Glu Asp Ala Asp Glu 
    370                 375                 380                 


Pro Gly Arg Val Pro Thr Glu Asp Tyr Met Ser His Ile Ile Glu Lys 
385                 390                 395                 400 


Trp 
    


<210>  1485
<211>  5096
<212>  DNA
<213>  Homosapiens

<400>  1485
atgaggagat ctgtctactg caaggtggtt ctagccactt cgctgatgtg ggttcttgtt     60

gatgtcttct tactgctgta cttcagtgaa tgtaacaaat gtgatgacaa gaaggagaga    120

tctctgctgc ctgcattgag ggctgttatt tcaagaaacc aagaagggcc aggagaaatg    180

ggaaaagctg tgttgattcc taaagatgac caggagaaaa tgaaagagct gtttaaaatc    240

aatcagttta accttatggc cagtgatttg attgccctta atagaagtct gccagatgta    300

agattagaag gatgtaagac aaaagtctac cctgatgaac ttccaaacac aagtgtagtc    360

attgtgtttc ataatgaagc ttggagcact ctccttagaa ctgtttacag tgtgataaat    420

cgttccccac actatctact ctcagaggtc atcttggtag atgatgccag tgaaagagat    480

tttctcaagt tgacattaga gaattacgtg aaaaatttag aagtgccagt aaaaattatt    540

aggatggaag aacgctctgg gttaatacgt gcccgtcttc gaggagcagc tgcttcaaaa    600

gggcaggtca taacttttct tgatgcacac tgtgaatgca cgttaggatg gctggagcct    660

ttgctggcaa gaataaagga agacaggaaa acggttgtct gccctatcat tgatgtgatt    720

agtgatgata cttttgaata tatggctggg tcagacatga cttatggggg ttttaactgg    780

aaactgaatt tccgctggta tcctgttccc caaagagaaa tggacaggag gaaaggagac    840

agaacattac ctgtcaggac ccctactatg gctggtggcc tattttctat tgacagaaac    900

tactttgaag agataggaac ttacgatgca ggaatggata tctggggtgg agagaatctt    960

gaaatgtctt ttaggatttg gcaatgtgga ggctccttgg agattgttac ttgctcccat   1020

gttggtcatg tttttcggaa ggcaactcca tacacttttc ctggtggcac tggtcatgtc   1080

atcaacaaga acaacaggag actggcagaa gtttggatgg atgaatttaa agatttcttc   1140

tacatcatat ccccaggtgt tgtcaaagtg gattatggag atgtgtcagt cagaaaaaca   1200

ctaagagaaa atctgaagtg taagcccttt tcttggtacc tagaaaacat ctatccggac   1260

tcccagatcc caagacgtta ttactcactt ggtgagataa gaaatgttga aaccaatcag   1320

tgtttagaca acatgggccg caaggaaaat gaaaaagtgg gtatattcaa ctgtcatggt   1380

atgggaggaa atcaggtatt ttcttacact gctgacaaag aaatccgaac cgatgacttg   1440

tgcttggatg tttctagact caatggacct gtaatcatgt taaaatgcca ccatatgaga   1500

ggaaatcagt tatgggaata tgatgctgag agactcacgt tgcgacatgt taacagtaac   1560

caatgtctcg atgaaccttc tgaagaagac aaaatggtgc ctacaatgca ggactgtagt   1620

ggaagcagat cccaacagtg gctgctaagg aacatgacct tgggcacatg aagatcatgt   1680

cctccaagcc atgaaagtgt ctacgctttt gtttttccat tatttcaatt gggggaaaat   1740

attaactttg ctgaattgaa agttttaaaa atccttttag tattctaaaa cacaattgtt   1800

tctaattcgt ttctagaaat gtttgcttat ttccctacta aaatttgtat ctgatcaaag   1860

cacataagaa tataaataat agcaaactac tattaaacaa cagaacaact tgtaaaacaa   1920

attgtgtttg ctttaagaaa aatctttatt gcactcatgt catagggtta attggaggtt   1980

attttatttt tggttgtcat ggtgattgaa agagataatg taaatgcctt ataaaatctt   2040

cattatgaaa tattatcagt tgctttataa actcactctt tttatggatc cttcatggaa   2100

acatgtttga tttctgtgtc tacaacaggg ccacatatta aattacttct gaatggtgaa   2160

ttcatcttac aaaatgttcc aagttttgga caaggaaaaa cattacattg gatattgaat   2220

tcatggagcc tttacagaag catcacattt aaaccaatgt gaattcaaaa aagagaagga   2280

aactttttaa attcaattta gagtacataa aaaaagaaat ccgcgaagca ttgaggggaa   2340

caagatgagt ctaatccgca gcacttcgat cactgtgaga gaactcaaag tgggttgcaa   2400

tcattcctaa cacaggctga aactaaacaa tcttgctccc agagtttatg ttggatactc   2460

aattcttaac caaaatcttg gtctccacaa actctaccat cccttttctc ttcactctat   2520

agacagtggc atgccattga tgctgtacag aattgcaggt gaaagggaga attttagact   2580

taatttttaa ctctattgca cttaaagatt ttagttaggt taccactgtc attttcattt   2640

tctatgttaa agaatacctt tcagtgctgt gctccagtat ctaaaaattt tatcaccagg   2700

ggaataaact caatacacat tcattaaact tttgttgtaa ttaaactgct atatattgtt   2760

tgccatatat tatggcccaa ggaatatagt tataatcagg ctacattcac attttctttt   2820

ctcatcttaa aaccctttat gttcaaaata cattagcaga ggccatgaaa gtgaaaaaaa   2880

atcagatttt tgctagtaag tttttatatt tgacatcatt ttaaatgctc aaagagttgc   2940

cctatatatg catgttatcc attataaatg cactcagcag ctaagagaaa tttgagagga   3000

aaagtggaag aagtgttttc tggagcagaa gattccactt ctttggtcct catctttact   3060

taaaaagctc ttatagaaag gattaatcat tttgactgca tacaaactat gtctctgaca   3120

tgcacataca ctgctttata atgaaaatga ggacactttc tgatggtcag taaaatctta   3180

aatgattttt gccactggta ttccttcctc ttttgacttt ttattggtac aactgtaggg   3240

aagaatctac aacctggagc atttcaggtt tgctctttac atatagacac ccctcaccat   3300

gagctctctg tgaatccgtg aatttcctaa aattgtaagc aaaatgttga atatcagggc   3360

attttttttt ctgaggtggg agtatgtcac tcacagcaaa cttggaaaga aggctatgac   3420

tcccaagagg cagtgaacca ttgccttaaa ttaatagcag cctctcaagt ccattgaggc   3480

ctcatgtaaa attcccattt ttcatcttta cactcctttt ctcccctcat ttcctcttct   3540

ccttactaag gtaaaaagac cctgcacagc attattactt aagttgaaaa agcttcaact   3600

ctcaaggact catgtatacc atatgttcca cttattgctt tgttagtcaa aatgcatgtt   3660

atgtagaaaa tggtcaatgg caaattttta taaatacagc taccccatca aagctgaact   3720

tgaaacgttt tagcagaatt ttaaatatgt gaaagttcat tgtggtcatg gtgagaaaac   3780

taaaactaca tgagtttcat gttagaaaag aatttttaaa caatcttcag atggcttgaa   3840

cacgtgccat tatagtatct aacaaaaagt ggcataaaat attacaaaac atccaacact   3900

agaaagcaat gactaacatt taatttgttt acaaaaatgt ttattgtctt cagtacaaaa   3960

agttaaaacc atgattggat tcataatgca cttgtcttat cccttattta tggagctaga   4020

ctgacatatt tcaaaccaat ctcttctgtg gtcttctcca tctcagttaa tgcaacttca   4080

accttccaga tgctcaggtc aaaaactgaa agttgctttt gactcctcta tttctgtttc   4140

aactctcgtc taatccaaca gcaaatcccc ttgatgctac ctttgaaata taactagaaa   4200

agaatgactt gccaccatat ccactaggtg tcactacctc taaccttttt aatcgcaata   4260

tgcttattat ttagttccct aatttcccag tccttgtctt gaacaatctt ttctcagtac   4320

aacagccata gtgattctgt taaccatgaa tttgattgtg tcacttccct gctcacaatc   4380

ttccaatgac ttctccctcc ggtggccttc aaggtccttt atgagtgtta cccctctaca   4440

cgtccacacc actcaccaca catacataca catgcacaca cacacacatg caattctacc   4500

tttttctaac accatctctt atctctcatt attctgcctc ttacttaccc tattatggct   4560

cccaagaaag ttcctgcttt agtgttttgt tccctctgcc ccagagagct ccccttagtg   4620

atctcagttc aaatattatc ttatcagtaa gacaaaccct tctcccatct gccttcccta   4680

tcccctgtac ctgacaatct atgagtttgc ttctttattt ctgtctatac ttccccctcc   4740

ccagccccaa acatgcccat cacatgccct agaaggtaag tcccatgaag gcaggggctt   4800

tgtcagtttt gttcatttgg tatttctggc atatatattc tctaaatatt tcttgaatta   4860

atgaactgaa aaatgtgtgt taaagttgct aagtgtaact gtatcatact ttttttgtat   4920

tttaaatttt aaaataaagg ctaatatatt tagacaggat ttccaaaaac tttgtcttca   4980

aattttaatt ttcttcctaa tattcttcac attaaactat ggactctaat tttctggata   5040

aaatatcctg ccttatggaa atgaaatatg aaattttatt aaaatgctgc tatatt       5096


<210>  1486
<211>  556
<212>  PRT
<213>  Homosapiens

<400>  1486

Met Arg Arg Ser Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu 
            500                 505                 510         


Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu 
        515                 520                 525             


Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser 
    530                 535                 540                 


Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
545                 550                 555     


<210>  1487
<211>  4225
<212>  DNA
<213>  Homosapiens

<400>  1487
ggccccctcc ggaaggtgag gggaatggat tggactccgg tggggaaagc gggtgtctag     60

aagtggtgct aatgggaaga gaattctggt ttcaaaagag gatgctctgc cacaaagagc    120

ggctcgcgcg ctggcctggg ctctagccga ggagagatcc cgggagaact ccagagctcc    180

gggggagcgc tcctcggaag accggggcca acatgcctgt gcgcaggggg catgtggcac    240

cacaaaatac atttctgggg accatcattc ggaaatttga agggcaaaat aaaaaattta    300

tcattgcaaa tgccagagtg cagaactgtg ccatcattta ttgcaacgat gggttctgtg    360

agatgactgg tttctccagg ccagatgtca tgcaaaagcc atgcacctgc gactttctcc    420

atggacccga gaccaagagg catgatattg cccaaattgc ccaggcattg ctggggtcag    480

aagagaggaa agtggaggtc acctactatc acaaaaatgg gtccactttt atttgtaaca    540

ctcacataat tccagtgaaa aaccaagagg gcgtggctat gatgttcatc attaattttg    600

aatatgtgac ggataatgaa aacgctgcca ccccagagag ggtaaaccca atattaccaa    660

tcaaaactgt aaaccggaaa ttttttgggt tcaaattccc tggtctgaga gttctcactt    720

acagaaagca gtccttacca caagaagacc ccgatgtggt ggtcatcgat tcatctaaac    780

acagtgatga ttcagtagcc atgaagcatt ttaagtctcc tacaaaagaa agctgcagcc    840

cctctgaagc agatgacaca aaagctttga tacagcccag caaatgttct cccttggtga    900

atatatccgg acctcttgac cattcctctc ccaaaaggca atgggaccga ctctaccctg    960

acatgctgca gtcaagttcc cagctgtccc attccagatc aagggaaagc ttatgtagta   1020

tacggagagc atcttcggtc catgatatag aaggattcgg cgtccacccc aagaacatat   1080

ttagagaccg acatgccagc gaagacaatg gtcgcaatgt caaagggcct tttaatcata   1140

tcaagtcaag cctcctggga tccacatcag attcaaacct caacaaatac agcaccatta   1200

acaagattcc acagctcact ctgaattttt cagaggtcaa aactgagaaa aagaattcat   1260

cacctccttc ttcagataaa accattattg cacccaaggt taaagatcga acacacaatg   1320

tgactgagaa agtgacccag gttctctctt taggagcaga tgtcctacct gaatacaaac   1380

tgcagacacc acgcatcaac aagtttacga tattgcacta cagccctttc aaggcagtct   1440

gggactggct tatcctgctg ttggtcatat acactgctat atttactccc tactctgcag   1500

ccttcctcct caatgacaga gaagaacaga aaagacgaga atgtggctat tcttgtagcc   1560

ctttgaatgt ggtagacttg attgtggata ttatgtttat catagatatt ttaataaact   1620

tcagaacaac atatgtaaat cagaatgaag aagtggtaag tgatcccgcc aaaatagcaa   1680

tacactactt caaaggctgg ttcctgattg acatggttgc agcaattcct tttgacttgc   1740

tgatttttgg atcaggttct gatgagacaa caacattaat tggtcttttg aagactgccc   1800

gactcctccg tcttgtgcgc gtggccagga aactggatcg atattcagaa tatggcgctg   1860

ctgttctaat gctcttaatg tgcatctttg ccctgattgc tcactggctg gcttgcattt   1920

ggtatgcgat tgggaatgta gaaaggcctt acctgactga caaaatcgga tggttggatt   1980

ccttaggaca gcaaattggg aaacgttaca atgacagtga ctcaagttct ggaccatcca   2040

ttaaagacaa atacgtcaca gcactttatt ttaccttcag cagtttaacc agtgtaggat   2100

tcgggaatgt gtctcctaac acgaattcgg agaaaatctt ttcaatttgt gtcatgttga   2160

ttggctcact aatgtatgca agcatttttg ggaatgtatc tgcaattatc caaagactat   2220

actcgggaac tgccaggtac cacatgcaga tgctgcgagt aaaagagttc attcgctttc   2280

accaaatccc caaccctctg aggcaacgtc ttgaagaata tttccagcac gcatggactt   2340

acaccaatgg cattgacatg aacatggtcc taaagggttt cccagaatgc ttacaagcag   2400

acatttgtct acatctcaac cagacattgc tgcaaaactg caaagccttt cggggggcaa   2460

gtaaaggttg ccttagagct ttggcaatga agttcaaaac cacccatgca cctccaggag   2520

acaccctcgt tcactgtggg gatgtcctca ctgcacttta tttcttatcc agaggctcca   2580

ttgaaattct caaagatgac attgtggtgg ctattctggg aaaaaatgat atatttggag   2640

aaatggttca tctttatgcc aaacctggaa agtctaatgc agatgtaaga gccctcacat   2700

actgtgactt gcataagatt cagcgagaag acttgttaga ggttttggat atgtatcctg   2760

agttttctga tcactttcta acaaacctag agttgacttt caacctaagg catgagagcg   2820

caaaggctga tctcctacga tcacaatcca tgaatgattc agaaggagac aactgtaaac   2880

taagaagaag gaaattgtca tttgaaagtg aaggagagaa agaaaacagt acaaatgatc   2940

ctgaagactc tgcagatacc ataagacatt atcagagttc caagagacac tttgaagaga   3000

aaaaaagcag atcctcatct ttcatctcct ccattgatga tgaacaaaag ccgctcttct   3060

caggaatagt agactcttct ccaggaatag ggaaagcatc tgggctcgat tttgaagaaa   3120

cagtgcccac ctcaggaaga atgcacatag ataaaagaag tcactcttgc aaagatatca   3180

ctgacatgcg aagctgggaa cgagaaaatg cacatcccca gcctgaagac tccagtccat   3240

ctgcacttca gcgagctgcc tggggtatct ctgaaaccga aagcgacctc acctacgggg   3300

aagtggaaca aagattagat ctgctccagg agcaacttaa caggcttgaa tcccaaatga   3360

ccactgacat ccagaccatc ttacagttgc tgcagaaaca aaccactgtg gtccccccag   3420

cctacagtat ggtaacagca ggatcagaat atcagagacc catcatccag ctgatgagaa   3480

ccagtcaacc ggaagcatcc atcaaaactg accgaagttt cagcccttcc tcacaatgtc   3540

ctgaatttct agaccttgaa aaatctaaac ttaaatccaa agaatccctt tcaagtgggg   3600

tgcatctgaa cacagcttca gaagacaact tgacttcact tttaaaacaa gacagtgatc   3660

tctctttaga gcttcacctg cggcaaagaa aaacttacgt tcatccaatt aggcatcctt   3720

ctttgccaga ttcatcccta agcactgtag gaatcgtggg tcttcatagg catgtttctg   3780

atcctggtct tccagggaaa taatcatttt gtactattta ctccacatac aatgtaagtg   3840

cttttaatgg ctgttttcct ttttctattt aaatcctctc tacttgactc aggggctcac   3900

aaggtaccat tatatgcaaa agtactgtat attttcctaa attgaagctt gtaaggtaaa   3960

actgagcagt taggatgtaa atatacataa gaacttttgg ttccaaatgt taaaactgcc   4020

agcatctcac ggcaccttat tttttatttt tattttttaa atcacatgca tgttaggaaa   4080

ctccaatttc tcttgcatgg agactcctat ttactgcttt tactaaacca gtacttcgtt   4140

atgaaaatgc cttccacgca aataagaaac caagggataa aactgttcat ggatgcaact   4200

caaattcaga tgatcctcaa ctcat                                         4225


<210>  1488
<211>  1196
<212>  PRT
<213>  Homosapiens

<400>  1488

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 
                85                  90                  95      


Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 
            100                 105                 110         


Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 
        115                 120                 125             


Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 
    130                 135                 140                 


Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 
145                 150                 155                 160 


Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 
                165                 170                 175     


Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 
            180                 185                 190         


Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 
        195                 200                 205             


Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 
    210                 215                 220                 


Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 
225                 230                 235                 240 


Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 
                245                 250                 255     


Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 
            260                 265                 270         


Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 
        275                 280                 285             


Ile Phe Arg Asp Arg His Ala Ser Glu Asp Asn Gly Arg Asn Val Lys 
    290                 295                 300                 


Gly Pro Phe Asn His Ile Lys Ser Ser Leu Leu Gly Ser Thr Ser Asp 
305                 310                 315                 320 


Ser Asn Leu Asn Lys Tyr Ser Thr Ile Asn Lys Ile Pro Gln Leu Thr 
                325                 330                 335     


Leu Asn Phe Ser Glu Val Lys Thr Glu Lys Lys Asn Ser Ser Pro Pro 
            340                 345                 350         


Ser Ser Asp Lys Thr Ile Ile Ala Pro Lys Val Lys Asp Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Thr Pro Arg Ile Asn Lys Phe Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Ile Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Asn Asp Arg Glu Glu Gln Lys Arg Arg Glu Cys Gly Tyr Ser Cys 
        435                 440                 445             


Ser Pro Leu Asn Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Ile 
    450                 455                 460                 


Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Gln Asn Glu Glu 
465                 470                 475                 480 


Val Val Ser Asp Pro Ala Lys Ile Ala Ile His Tyr Phe Lys Gly Trp 
                485                 490                 495     


Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe 
            500                 505                 510         


Gly Ser Gly Ser Asp Glu Thr Thr Thr Leu Ile Gly Leu Leu Lys Thr 
        515                 520                 525             


Ala Arg Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr 
    530                 535                 540                 


Ser Glu Tyr Gly Ala Ala Val Leu Met Leu Leu Met Cys Ile Phe Ala 
545                 550                 555                 560 


Leu Ile Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Val 
                565                 570                 575     


Glu Arg Pro Tyr Leu Thr Asp Lys Ile Gly Trp Leu Asp Ser Leu Gly 
            580                 585                 590         


Gln Gln Ile Gly Lys Arg Tyr Asn Asp Ser Asp Ser Ser Ser Gly Pro 
        595                 600                 605             


Ser Ile Lys Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser 
    610                 615                 620                 


Leu Thr Ser Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu 
625                 630                 635                 640 


Lys Ile Phe Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala 
                645                 650                 655     


Ser Ile Phe Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly 
            660                 665                 670         


Thr Ala Arg Tyr His Met Gln Met Leu Arg Val Lys Glu Phe Ile Arg 
        675                 680                 685             


Phe His Gln Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe 
    690                 695                 700                 


Gln His Ala Trp Thr Tyr Thr Asn Gly Ile Asp Met Asn Met Val Leu 
705                 710                 715                 720 


Lys Gly Phe Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn 
                725                 730                 735     


Gln Thr Leu Leu Gln Asn Cys Lys Ala Phe Arg Gly Ala Ser Lys Gly 
            740                 745                 750         


Cys Leu Arg Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro 
        755                 760                 765             


Gly Asp Thr Leu Val His Cys Gly Asp Val Leu Thr Ala Leu Tyr Phe 
    770                 775                 780                 


Leu Ser Arg Gly Ser Ile Glu Ile Leu Lys Asp Asp Ile Val Val Ala 
785                 790                 795                 800 


Ile Leu Gly Lys Asn Asp Ile Phe Gly Glu Met Val His Leu Tyr Ala 
                805                 810                 815     


Lys Pro Gly Lys Ser Asn Ala Asp Val Arg Ala Leu Thr Tyr Cys Asp 
            820                 825                 830         


Leu His Lys Ile Gln Arg Glu Asp Leu Leu Glu Val Leu Asp Met Tyr 
        835                 840                 845             


Pro Glu Phe Ser Asp His Phe Leu Thr Asn Leu Glu Leu Thr Phe Asn 
    850                 855                 860                 


Leu Arg His Glu Ser Ala Lys Ala Asp Leu Leu Arg Ser Gln Ser Met 
865                 870                 875                 880 


Asn Asp Ser Glu Gly Asp Asn Cys Lys Leu Arg Arg Arg Lys Leu Ser 
                885                 890                 895     


Phe Glu Ser Glu Gly Glu Lys Glu Asn Ser Thr Asn Asp Pro Glu Asp 
            900                 905                 910         


Ser Ala Asp Thr Ile Arg His Tyr Gln Ser Ser Lys Arg His Phe Glu 
        915                 920                 925             


Glu Lys Lys Ser Arg Ser Ser Ser Phe Ile Ser Ser Ile Asp Asp Glu 
    930                 935                 940                 


Gln Lys Pro Leu Phe Ser Gly Ile Val Asp Ser Ser Pro Gly Ile Gly 
945                 950                 955                 960 


Lys Ala Ser Gly Leu Asp Phe Glu Glu Thr Val Pro Thr Ser Gly Arg 
                965                 970                 975     


Met His Ile Asp Lys Arg Ser His Ser Cys Lys Asp Ile Thr Asp Met 
            980                 985                 990         


Arg Ser Trp Glu Arg Glu Asn Ala  His Pro Gln Pro Glu  Asp Ser Ser 
        995                 1000                 1005             


Pro Ser  Ala Leu Gln Arg Ala  Ala Trp Gly Ile Ser  Glu Thr Glu 
    1010                 1015                 1020             


Ser Asp  Leu Thr Tyr Gly Glu  Val Glu Gln Arg Leu  Asp Leu Leu 
    1025                 1030                 1035             


Gln Glu  Gln Leu Asn Arg Leu  Glu Ser Gln Met Thr  Thr Asp Ile 
    1040                 1045                 1050             


Gln Thr  Ile Leu Gln Leu Leu  Gln Lys Gln Thr Thr  Val Val Pro 
    1055                 1060                 1065             


Pro Ala  Tyr Ser Met Val Thr  Ala Gly Ser Glu Tyr  Gln Arg Pro 
    1070                 1075                 1080             


Ile Ile  Gln Leu Met Arg Thr  Ser Gln Pro Glu Ala  Ser Ile Lys 
    1085                 1090                 1095             


Thr Asp  Arg Ser Phe Ser Pro  Ser Ser Gln Cys Pro  Glu Phe Leu 
    1100                 1105                 1110             


Asp Leu  Glu Lys Ser Lys Leu  Lys Ser Lys Glu Ser  Leu Ser Ser 
    1115                 1120                 1125             


Gly Val  His Leu Asn Thr Ala  Ser Glu Asp Asn Leu  Thr Ser Leu 
    1130                 1135                 1140             


Leu Lys  Gln Asp Ser Asp Leu  Ser Leu Glu Leu His  Leu Arg Gln 
    1145                 1150                 1155             


Arg Lys  Thr Tyr Val His Pro  Ile Arg His Pro Ser  Leu Pro Asp 
    1160                 1165                 1170             


Ser Ser  Leu Ser Thr Val Gly  Ile Val Gly Leu His  Arg His Val 
    1175                 1180                 1185             


Ser Asp  Pro Gly Leu Pro Gly  Lys 
    1190                 1195     


<210>  1489
<211>  2488
<212>  DNA
<213>  Homosapiens

<400>  1489
ggccccctcc ggaaggtgag gggaatggat tggactccgg tggggaaagc gggtgtctag     60

aagtggtgct aatgggaaga gaattctggt ttcaaaagag gatgctctgc cacaaagagc    120

ggctcgcgcg ctggcctggg ctctagccga ggagagatcc cgggagaact ccagagctcc    180

gggggagcgc tcctcggaag accggggcca acatgcctgt gcgcaggggg catgtggcac    240

cacaaaatac atttctgggg accatcattc ggaaatttga agggcaaaat aaaaaattta    300

tcattgcaaa tgccagagtg cagaactgtg ccatcattta ttgcaacgat gggttctgtg    360

agatgactgg tttctccagg ccagatgtca tgcaaaagcc atgcacctgc gactttctcc    420

atggacccga gaccaagagg catgatattg cccaaattgc ccaggcattg ctggggtcag    480

aagagaggaa agtggaggtc acctactatc acaaaaatgg gtccactttt atttgtaaca    540

ctcacataat tccagtgaaa aaccaagagg gcgtggctat gatgttcatc attaattttg    600

aatatgtgac ggataatgaa aacgctgcca ccccagagag ggtaaaccca atattaccaa    660

tcaaaactgt aaaccggaaa ttttttgggt tcaaattccc tggtctgaga gttctcactt    720

acagaaagca gtccttacca caagaagacc ccgatgtggt ggtcatcgat tcatctaaac    780

acagtgatga ttcagtagcc atgaagcatt ttaagtctcc tacaaaagaa agctgcagcc    840

cctctgaagc agatgacaca aaagctttga tacagcccag caaatgttct cccttggtga    900

atatatccgg acctcttgac cattcctctc ccaaaaggca atgggaccga ctctaccctg    960

acatgctgca gtcaagttcc cagctgtccc attccagatc aagggaaagc ttatgtagta   1020

tacggagagc atcttcggtc catgatatag aaggattcgg cgtccacccc aagaacatat   1080

ttagagaccg acatgccagc gaagggcctt ttaatcatat caagtcaagc ctcctgggat   1140

ccacatcaga ttcaaacctc aacaaataca gcaccattaa caagattcca cagctcactc   1200

tgaatttttc agaggtcaaa actgagaaaa agaattcatc acctccttct tcagataaaa   1260

ccattattgc acccaaggtt aaagatcgaa cacacaatgt gactgagaaa gtgacccagg   1320

ttctctcttt aggagcagat gtcctacctg aatacaaact gcagacacca cgcatcaaca   1380

agtttacgat attgcactac agccctttca aggcagtctg ggactggctt atcctgctgt   1440

tggtcatata cactgctata tttactccct actctgcagc cttcctcctc aatgacagag   1500

aagaacagaa aagacgagaa tgtggctatt cttgtagccc tttgaatgtg gtagacttga   1560

ttgtggatat tatgtttatc atagatattt taataaactt cagaacaaca tatgtaaatc   1620

agaatgaaga agtggtaagt gatcccgcca aaatagcaat acactacttc aaaggctggt   1680

tcctgattga catggttgca gcaattcctt ttgacttgct gatttttgga tcaggttctg   1740

atgagacaac aacattaatt ggtcttttga agactgcccg actcctccgt cttgtgcgcg   1800

tggccaggaa actggatcga tattcagaat atggcgctgc tgttctaatg ctcttaatgt   1860

gcatctttgc cctgattgct cactggctgg cttgcatttg gtatgcgatt gggaatgtag   1920

aaaggcctta cctgactgac aaaatcggat ggttggattc cttaggacag caaattggga   1980

aacgttacaa tgacagtgac tcaagttctg gaccatccat taaagacaaa tacgtcacag   2040

cactttattt taccttcagc agtttaacca gtgtaggatt cgggaatgtg tctcctaaca   2100

cgaattcgga gaaaatcttt tcaatttgtg tcatgttgat tggctcacta atgtatgcaa   2160

gcatttttgg gaatgtatct gcaattatcc aaagactata ctcgggaact gccaggtacc   2220

acatgcagat gctgcgagta aaagagttca ttcgctttca ccaaatcccc aaccctctga   2280

ggcaacgtct tgaagaatat ttccagcacg catggactta caccaatggc attgacatga   2340

acatggtatg tatgtctgtt ttccaaaatg aaagtgccgc aggcattata gtgatagcca   2400

aaatggaata aaagccggaa tcaccagctt tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      2488


<210>  1490
<211>  732
<212>  PRT
<213>  Homosapiens

<400>  1490

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 
                85                  90                  95      


Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 
            100                 105                 110         


Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 
        115                 120                 125             


Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 
    130                 135                 140                 


Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 
145                 150                 155                 160 


Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 
                165                 170                 175     


Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 
            180                 185                 190         


Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 
        195                 200                 205             


Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 
    210                 215                 220                 


Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 
225                 230                 235                 240 


Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 
                245                 250                 255     


Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 
            260                 265                 270         


Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 
        275                 280                 285             


Ile Phe Arg Asp Arg His Ala Ser Glu Gly Pro Phe Asn His Ile Lys 
    290                 295                 300                 


Ser Ser Leu Leu Gly Ser Thr Ser Asp Ser Asn Leu Asn Lys Tyr Ser 
305                 310                 315                 320 


Thr Ile Asn Lys Ile Pro Gln Leu Thr Leu Asn Phe Ser Glu Val Lys 
                325                 330                 335     


Thr Glu Lys Lys Asn Ser Ser Pro Pro Ser Ser Asp Lys Thr Ile Ile 
            340                 345                 350         


Ala Pro Lys Val Lys Asp Arg Thr His Asn Val Thr Glu Lys Val Thr 
        355                 360                 365             


Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln 
    370                 375                 380                 


Thr Pro Arg Ile Asn Lys Phe Thr Ile Leu His Tyr Ser Pro Phe Lys 
385                 390                 395                 400 


Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Ile 
                405                 410                 415     


Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Asn Asp Arg Glu Glu Gln 
            420                 425                 430         


Lys Arg Arg Glu Cys Gly Tyr Ser Cys Ser Pro Leu Asn Val Val Asp 
        435                 440                 445             


Leu Ile Val Asp Ile Met Phe Ile Ile Asp Ile Leu Ile Asn Phe Arg 
    450                 455                 460                 


Thr Thr Tyr Val Asn Gln Asn Glu Glu Val Val Ser Asp Pro Ala Lys 
465                 470                 475                 480 


Ile Ala Ile His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala 
                485                 490                 495     


Ala Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly Ser Asp Glu Thr 
            500                 505                 510         


Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
        515                 520                 525             


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
    530                 535                 540                 


Leu Met Leu Leu Met Cys Ile Phe Ala Leu Ile Ala His Trp Leu Ala 
545                 550                 555                 560 


Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Thr Asp 
                565                 570                 575     


Lys Ile Gly Trp Leu Asp Ser Leu Gly Gln Gln Ile Gly Lys Arg Tyr 
            580                 585                 590         


Asn Asp Ser Asp Ser Ser Ser Gly Pro Ser Ile Lys Asp Lys Tyr Val 
        595                 600                 605             


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
    610                 615                 620                 


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe Ser Ile Cys Val 
625                 630                 635                 640 


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
                645                 650                 655     


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Met Gln 
            660                 665                 670         


Met Leu Arg Val Lys Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
        675                 680                 685             


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Thr Tyr Thr 
    690                 695                 700                 


Asn Gly Ile Asp Met Asn Met Val Cys Met Ser Val Phe Gln Asn Glu 
705                 710                 715                 720 


Ser Ala Ala Gly Ile Ile Val Ile Ala Lys Met Glu 
                725                 730         


<210>  1491
<211>  651
<212>  DNA
<213>  Homosapiens

<400>  1491
atggctgaga cagcagctag tcctgtgagg gcagagggaa tctcaggaaa tgtagacgat     60

gtctctgata aatatatgcc tgtcataaac gatgacctgc ggcatacaac gactgagatc    120

tccgagatga accggaacat cagctggctc caggctgaga ttgagggtct caaaggccag    180

aaggcttccc tggaggccgc cgtcgcagat gctgagcagc gtggggagct ggccattaag    240

gatgccaacg ccaagctgtc cgagctggag gcggccctgc agcgggccaa gcaagacatg    300

gcatggcagt tgcatgagta ccaggagctg atgaacatca agctggccct ggatatggag    360

atcgccacct acaggaagct gctggagggc aaggacagcc ggctggagtc tgggatgcag    420

aacatgagta tccatacgaa gaccaccagc agctatgcag gtggtctgag ctcggcctat    480

gggggcctca caagccccag cctcagctac ggcctgggct ccagctttgg ctctggcgtg    540

ggctccagct ccttcagcca cagcagctcc accagggccg tggttgtgaa gaagatacag    600

acccgcaatg ggaagctggt gtccgagtct tctgacgtcc tgcgcaagtg a             651


<210>  1492
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  1492

Met Ala Glu Thr Ala Ala Ser Pro Val Arg Ala Glu Gly Ile Ser Gly 
1               5                   10                  15      


Asn Val Asp Asp Val Ser Asp Lys Tyr Met Pro Val Ile Asn Asp Asp 
            20                  25                  30          


Leu Arg His Thr Thr Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser 
        35                  40                  45              


Trp Leu Gln Ala Glu Ile Glu Gly Leu Lys Gly Gln Lys Ala Ser Leu 
    50                  55                  60                  


Glu Ala Ala Val Ala Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys 
65                  70                  75                  80  


Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala 
                85                  90                  95      


Lys Gln Asp Met Ala Trp Gln Leu His Glu Tyr Gln Glu Leu Met Asn 
            100                 105                 110         


Ile Lys Leu Ala Leu Asp Met Glu Ile Ala Thr Tyr Arg Lys Leu Leu 
        115                 120                 125             


Glu Gly Lys Asp Ser Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile 
    130                 135                 140                 


His Thr Lys Thr Thr Ser Ser Tyr Ala Gly Gly Leu Ser Ser Ala Tyr 
145                 150                 155                 160 


Gly Gly Leu Thr Ser Pro Ser Leu Ser Tyr Gly Leu Gly Ser Ser Phe 
                165                 170                 175     


Gly Ser Gly Val Gly Ser Ser Ser Phe Ser His Ser Ser Ser Thr Arg 
            180                 185                 190         


Ala Val Val Val Lys Lys Ile Gln Thr Arg Asn Gly Lys Leu Val Ser 
        195                 200                 205             


Glu Ser Ser Asp Val Leu Arg Lys 
    210                 215     


<210>  1493
<211>  1137
<212>  DNA
<213>  Homosapiens

<400>  1493
atggaggtaa aaccgccgcc cggtcgcccc cagcccgact ccggccgtcg ccgtcgccgc     60

cggggggagg agggccatga tccaaaggaa ccagagcagt tgagaaaact gtttattggt    120

ggtctgagct ttgaaactac agatgatagt ttacgagaac attttgagaa atggggcaca    180

ctcacagatt gtgtggtaat gagagacccc caaacaaaac gttccagggg ctttggtttt    240

gtgacttatt cttgtgttga agaggtggat gcagcaatgt gtgctcgacc acacaaggtt    300

gatgggcgtg tagtggaacc aaagagagct gtttctagag aggattctgt aaagcctggt    360

gcccatctaa cagtgaagaa aatttttgtt ggtggtatta aagaagatac agaagaatat    420

aatttgagag actactttga aaagtatggc aagattgaaa ccatagaagt tatggaagac    480

aggcagagtg gaaaaaagag aggatttgct tttgtaactt ttgatgatca tgatacagtt    540

gataaaattg ttgttcagaa ataccacact attaatgggc ataattgtga agtgaaaaag    600

gccctttcta aacaagaaat gcagtctgct ggatcacaga gaggtcgtgg aggtggatct    660

ggcaatttta tgggtcgcgg agggaacttt ggaggtggtg gaggtaattt tggccgtggt    720

ggaaactttg gtggaagagg aggctatggt ggtggaggtg gtggcagcag aggtagttat    780

ggaggaggtg atggtggata taatggattt ggaggtgatg gtggcaacta tggcggtggt    840

cctggttata gtagtagagg gggctatggt ggtggtggac caggatatgg aaaccaaggt    900

ggtggatatg gtggaggtgg aggatatgat ggttacaatg aaggaggaaa ttttggcggt    960

ggtaactatg gtggtggtgg gaactataat gattttggaa attatagtgg acaacagcaa   1020

tcaaattatg gacccatgaa agggggcagt tttggtggaa gaagctcggg cagtccctat   1080

ggtggtggtt atggatctgg tggtggaagt ggtggatatg gtagcagaag gttctaa      1137


<210>  1494
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  1494

Met Glu Val Lys Pro Pro Pro Gly Arg Pro Gln Pro Asp Ser Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
            20                  25                  30          


Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
        35                  40                  45              


Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
    50                  55                  60                  


Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
65                  70                  75                  80  


Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala Met Cys Ala Arg 
                85                  90                  95      


Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
            100                 105                 110         


Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
        115                 120                 125             


Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
    130                 135                 140                 


Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
145                 150                 155                 160 


Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp 
                165                 170                 175     


His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
            180                 185                 190         


Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys Gln Glu Met Gln 
        195                 200                 205             


Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met 
    210                 215                 220                 


Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                245                 250                 255     


Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly 
            260                 265                 270         


Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
        275                 280                 285             


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
    290                 295                 300                 


Gly Gly Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser 
                325                 330                 335     


Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly 
            340                 345                 350         


Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
    370                 375             


<210>  1495
<211>  2439
<212>  DNA
<213>  Homosapiens

<400>  1495
gcagccgcca ccgccgccgc cgccgccacc agagccgccc tgtccgcgcc gcgcctcggc     60

agccggaaca gggccgccgt cggggagccc caacacacgg tccacagctc atcatgatgg    120

acttggagct gccgccgccg ggactcccgt cccagcagga catggatttg attgacatac    180

tttggaggca agatatagat cttggagtaa gtcgagaagt atttgacttc agtcagcgac    240

ggaaagagta tgagctggaa aaacagaaaa aacttgaaaa ggaaagacaa gaacaactcc    300

aaaaggagca agagaaagcc tttttcgctc agttacaact agatgaagag acaggtgaat    360

ttctcccaat tcagccagcc cagcacatcc agtcagaaac cagtggatct gccaactact    420

cccaggttgc ccacattccc aaatcagatg ctttgtactt tgatgactgc atgcagcttt    480

tggcgcagac attcccgttt gtagatgaca atgaggtttc ttcggctacg tttcagtcac    540

ttgttcctga tattcccggt cacatcgaga gcccagtctt cattgctact aatcaggctc    600

agtcacctga aacttctgtt gctcaggtag cccctgttga tttagacggt atgcaacagg    660

acattgagca agtttgggag gagctattat ccattcctga gttacagtgt cttaatattg    720

aaaatgacaa gctggttgag actaccatgg ttccaagtcc agaagccaaa ctgacagaag    780

ttgacaatta tcatttttac tcatctatac cctcaatgga aaaagaagta ggtaactgta    840

gtccacattt tcttaatgct tttgaggatt ccttcagcag catcctctcc acagaagacc    900

ccaaccagtt gacagtgaac tcattaaatt cagatgccac agtcaacaca gattttggtg    960

atgaatttta ttctgctttc atagctgagc ccagtatcag caacagcatg ccctcacctg   1020

ctactttaag ccattcactc tctgaacttc taaatgggcc cattgatgtt tctgatctat   1080

cactttgcaa agctttcaac caaaaccacc ctgaaagcac agcagaattc aatgattctg   1140

actccggcat ttcactaaac acaagtccca gtgtggcatc accagaacac tcagtggaat   1200

cttccagcta tggagacaca ctacttggcc tcagtgattc tgaagtggaa gagctagata   1260

gtgcccctgg aagtgtcaaa cagaatggtc ctaaaacacc agtacattct tctggggata   1320

tggtacaacc cttgtcacca tctcaggggc agagcactca cgtgcatgat gcccaatgtg   1380

agaacacacc agagaaagaa ttgcctgtaa gtcctggtca tcggaaaacc ccattcacaa   1440

aagacaaaca ttcaagccgc ttggaggctc atctcacaag agatgaactt agggcaaaag   1500

ctctccatat cccattccct gtagaaaaaa tcattaacct ccctgttgtt gacttcaacg   1560

aaatgatgtc caaagagcag ttcaatgaag ctcaacttgc attaattcgg gatatacgta   1620

ggaggggtaa gaataaagtg gctgctcaga attgcagaaa aagaaaactg gaaaatatag   1680

tagaactaga gcaagattta gatcatttga aagatgaaaa agaaaaattg ctcaaagaaa   1740

aaggagaaaa tgacaaaagc cttcacctac tgaaaaaaca actcagcacc ttatatctcg   1800

aagttttcag catgctacgt gatgaagatg gaaaacctta ttctcctagt gaatactccc   1860

tgcagcaaac aagagatggc aatgttttcc ttgttcccaa aagtaagaag ccagatgtta   1920

agaaaaacta gatttaggag gatttgacct tttctgagct agtttttttg tactattata   1980

ctaaaagctc ctactgtgat gtgaaatgct catactttat aagtaattct atgcaaaatc   2040

atagccaaaa ctagtataga aaataatacg aaactttaaa aagcattgga gtgtcagtat   2100

gttgaatcag tagtttcact ttaactgtaa acaatttctt aggacaccat ttgggctagt   2160

ttctgtgtaa gtgtaaatac tacaaaaact tatttatact gttcttatgt catttgttat   2220

attcatagat ttatatgatg atatgacatc tggctaaaaa gaaattattg caaaactaac   2280

cactatgtac ttttttataa atactgtatg gacaaaaaat ggcatttttt atattaaatt   2340

gtttagctct ggcaaaaaaa aaaaatttta agagctggta ctaataaagg attattatga   2400

ctgttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          2439


<210>  1496
<211>  605
<212>  PRT
<213>  Homosapiens

<400>  1496

Met Met Asp Leu Glu Leu Pro Pro Pro Gly Leu Pro Ser Gln Gln Asp 
1               5                   10                  15      


Met Asp Leu Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Val 
            20                  25                  30          


Ser Arg Glu Val Phe Asp Phe Ser Gln Arg Arg Lys Glu Tyr Glu Leu 
        35                  40                  45              


Glu Lys Gln Lys Lys Leu Glu Lys Glu Arg Gln Glu Gln Leu Gln Lys 
    50                  55                  60                  


Glu Gln Glu Lys Ala Phe Phe Ala Gln Leu Gln Leu Asp Glu Glu Thr 
65                  70                  75                  80  


Gly Glu Phe Leu Pro Ile Gln Pro Ala Gln His Ile Gln Ser Glu Thr 
                85                  90                  95      


Ser Gly Ser Ala Asn Tyr Ser Gln Val Ala His Ile Pro Lys Ser Asp 
            100                 105                 110         


Ala Leu Tyr Phe Asp Asp Cys Met Gln Leu Leu Ala Gln Thr Phe Pro 
        115                 120                 125             


Phe Val Asp Asp Asn Glu Val Ser Ser Ala Thr Phe Gln Ser Leu Val 
    130                 135                 140                 


Pro Asp Ile Pro Gly His Ile Glu Ser Pro Val Phe Ile Ala Thr Asn 
145                 150                 155                 160 


Gln Ala Gln Ser Pro Glu Thr Ser Val Ala Gln Val Ala Pro Val Asp 
                165                 170                 175     


Leu Asp Gly Met Gln Gln Asp Ile Glu Gln Val Trp Glu Glu Leu Leu 
            180                 185                 190         


Ser Ile Pro Glu Leu Gln Cys Leu Asn Ile Glu Asn Asp Lys Leu Val 
        195                 200                 205             


Glu Thr Thr Met Val Pro Ser Pro Glu Ala Lys Leu Thr Glu Val Asp 
    210                 215                 220                 


Asn Tyr His Phe Tyr Ser Ser Ile Pro Ser Met Glu Lys Glu Val Gly 
225                 230                 235                 240 


Asn Cys Ser Pro His Phe Leu Asn Ala Phe Glu Asp Ser Phe Ser Ser 
                245                 250                 255     


Ile Leu Ser Thr Glu Asp Pro Asn Gln Leu Thr Val Asn Ser Leu Asn 
            260                 265                 270         


Ser Asp Ala Thr Val Asn Thr Asp Phe Gly Asp Glu Phe Tyr Ser Ala 
        275                 280                 285             


Phe Ile Ala Glu Pro Ser Ile Ser Asn Ser Met Pro Ser Pro Ala Thr 
    290                 295                 300                 


Leu Ser His Ser Leu Ser Glu Leu Leu Asn Gly Pro Ile Asp Val Ser 
305                 310                 315                 320 


Asp Leu Ser Leu Cys Lys Ala Phe Asn Gln Asn His Pro Glu Ser Thr 
                325                 330                 335     


Ala Glu Phe Asn Asp Ser Asp Ser Gly Ile Ser Leu Asn Thr Ser Pro 
            340                 345                 350         


Ser Val Ala Ser Pro Glu His Ser Val Glu Ser Ser Ser Tyr Gly Asp 
        355                 360                 365             


Thr Leu Leu Gly Leu Ser Asp Ser Glu Val Glu Glu Leu Asp Ser Ala 
    370                 375                 380                 


Pro Gly Ser Val Lys Gln Asn Gly Pro Lys Thr Pro Val His Ser Ser 
385                 390                 395                 400 


Gly Asp Met Val Gln Pro Leu Ser Pro Ser Gln Gly Gln Ser Thr His 
                405                 410                 415     


Val His Asp Ala Gln Cys Glu Asn Thr Pro Glu Lys Glu Leu Pro Val 
            420                 425                 430         


Ser Pro Gly His Arg Lys Thr Pro Phe Thr Lys Asp Lys His Ser Ser 
        435                 440                 445             


Arg Leu Glu Ala His Leu Thr Arg Asp Glu Leu Arg Ala Lys Ala Leu 
    450                 455                 460                 


His Ile Pro Phe Pro Val Glu Lys Ile Ile Asn Leu Pro Val Val Asp 
465                 470                 475                 480 


Phe Asn Glu Met Met Ser Lys Glu Gln Phe Asn Glu Ala Gln Leu Ala 
                485                 490                 495     


Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln 
            500                 505                 510         


Asn Cys Arg Lys Arg Lys Leu Glu Asn Ile Val Glu Leu Glu Gln Asp 
        515                 520                 525             


Leu Asp His Leu Lys Asp Glu Lys Glu Lys Leu Leu Lys Glu Lys Gly 
    530                 535                 540                 


Glu Asn Asp Lys Ser Leu His Leu Leu Lys Lys Gln Leu Ser Thr Leu 
545                 550                 555                 560 


Tyr Leu Glu Val Phe Ser Met Leu Arg Asp Glu Asp Gly Lys Pro Tyr 
                565                 570                 575     


Ser Pro Ser Glu Tyr Ser Leu Gln Gln Thr Arg Asp Gly Asn Val Phe 
            580                 585                 590         


Leu Val Pro Lys Ser Lys Lys Pro Asp Val Lys Lys Asn 
        595                 600                 605 


<210>  1497
<211>  5207
<212>  DNA
<213>  Homosapiens

<400>  1497
gaccgcggcg acttggcggc gggtgccatg cgtctggagc ttcacattct ctgcccccca     60

cccaccgcgc cggcgctccc ttgtcacgcc tcgggaagcg cgcacctgcc aagcaggatg    120

aataatctga tatcatgtga aatgaggaaa taagaagctt tctgctgact tcattttgac    180

ccagggtcca aaaggtgatg taatcctgtg gcaagaagat tcaaaactgt ggactatctt    240

gcaaaaaata caagaagata ttgaaagttt tcatgagtgc ctaccaccta atctcaaaca    300

ctatcattca tatgtgcctc attgagcaaa tctttaatga ggatctatat gccagataat    360

gtaggcattg ttcctaagtc atgcagaggg gttgtgtaag catggtcatt tgcatcatta    420

tcctgcacgt ctgatacagc caaactccac gccacctggt ttgctcaaca gcaaaagaca    480

cggccgggtg cggtggctca cccctttgat cccagcactt tggaaggccg aggcgggcgg    540

atcatttgag caatatcttt tgcttgggag cagaaacaga aagtacatga tggacttcat    600

tgaaggatgg agatttggaa gacatgaatg gatgaagaac caagtgcgtg agggcaccta    660

tcaggattat tgctgaaatc cttatggagt taactggctg agaggaagta gagatggggt    720

ttcaccatgt tgcccaggct ggtctcaaac tcctgagctc aggccatctg cccgcctcgg    780

cctcccaaag tgctaggatt acagaaggtg cctgcttccc cttcaccttc caccatgatt    840

gtaagtttcc tgaggcctcc ccagacatgt ggaactaaca ggtttctctt attgcctgga    900

tccaagagca tctcctgggt tcttcctgtt agaatactga atgtccatgg agagtttaac    960

ataaggaaga agagggctgt ctcccagctg aaactggtgc agcagatcat gcaaagtaaa   1020

acctcagcag ctgtgatgaa gtagagcaga gggcctgggt gtctgtcagc tccaagcgga   1080

agatttcccc agctttctag gtaactgtgc ttccactgag caagccagac acagacttga   1140

atgtcatcac aatctgtgcc tgtgacatct ttccccaaga acagcacaaa ttgaactttt   1200

acattcttca taatatggaa ggaaaggtat tgactgagcc acttctttat gcctcaagac   1260

atctcatatg tatttatatg gatacataca tgaatgtata tattctgtca taataacata   1320

ttctattttt cttattatag cacagtgtta ggataggcta cataggctgc attaaaccct   1380

caaatagaag tttatattat gcatcagaag ccagtgcagg gactctcctc agcacaacat   1440

ctctaagtgg tgacttggag gttcaggctc ctttcatctt aaaatgccat catcttcagc   1500

atttggcctc aacagttgcc agagagggag aagagagtat gtataagacc acactgcagg   1560

atctgtggta ggtctgcaag cactgctgtc acctctgcca aatcccgtta gccagaaccc   1620

aatcatatgg ccccatccta actgcaaggg aagcctggga aaggtcttct tgtatgccag   1680

gaaaagaaaa tgaaatcgac aagtatctag ccagtctttg ctacaagttt ctacatgttg   1740

gaattattat ctatattttt cttctgatca tgcttagcat ttgatactat gtagactgcc   1800

ttgttgagtc ctactgtatt ttgtgacatc cacatgcagc atcccattcc tcacaacagg   1860

actaggagtg gtcagaagtt ttatcaccca ctttatggac ggaaaccctg agacccagag   1920

cagttacatg gcttgtccaa agttacatag tactgttaac ttaaaaacac aatttataaa   1980

tttagacaaa gaaagaggag actttatttc ttataaaggg ttatagcctt caaggtggct   2040

atctcacagg ctgggaagct cagccttcag cagaagccca gagacaagca ttttgaaggc   2100

agaggggttg ggatggagct ttatgctgaa caggttgact aaatatacat attcaacagg   2160

ttacaggagg agctatgaat attcatgagg gtggtcctga cacatgcgta ttgaacaaac   2220

atacatgtaa cacatgaccc atgttcactt tgggatggag acttaacatt tcagtgtatt   2280

acagttaggc cctacacatc aaaaggtcat ttcaggacac aaaagctcac aagtacacaa   2340

tctctgtaaa ctagtcagaa ccagtccatg gttggaaaaa gttactaaaa ttagtctctc   2400

atccaatgaa agctgtagtt atggctggtg gaacaggggt tcagttgggc agagtctatg   2460

agcaggatga tttgcaattg tttaaatatt gcttatcttg aggccagtgc ttgtttagct   2520

gctggagaaa aagaaaatcc ttgtggcagt tagagcatag tttcttcctt aggtgtagga   2580

gtacatgact tcccctcacc tggcatggcc ttaggtcctg tttataattc ggtatcttat   2640

tgccacaaag aatctgttct gtgagtcatg tgatctctat tggaacatta atgctgctca   2700

gttgttgtgt ctaaaccata aaagagaagg ggagtataat taggcatgtc tgacctctca   2760

tcatagctgg gaactaagtc tttaaatttt tttctggggt cctcttggcc acaagggggt   2820

ccatttagtc agtgggggcc ttgggattta tttttagttt acattgctaa gtgacagagc   2880

tttgcttctt tcactctgag gttagtggtc tctctgctgt gccacattgt cttccccaga   2940

agctcaaact ggatgcccag ccctcagtgt acaaactcaa gtatgcaaga aatacatctt   3000

tattctttta tgaatatacc taatttatat gttggaaggt gtcagcaatg aatttgatca   3060

ctttggtatt tctctacctt taaagatatg tttacatttg gggtgggatg aaggtttggt   3120

ggaggggaag gtggtcaggt tgggccaagg tattgggaaa tccatttgtt cctcatgtca   3180

gctgtttgag gaggcaccaa cccagatgtc cacagttcct tctggccttc ctttaccgat   3240

actgatgcac ctgtgcctcc ttcctgtgtg catggcccat ttgtgcccag catctccctg   3300

ctattttggg gccactccag ggtctgggaa gttctgtagg cttataacat acagtcattc   3360

ttctccccag cttgctgcct ccctgagaca cagaggtaga gaagtaggaa aggacctacc   3420

gtacccaggc ctttgccctc tcacttttca tccatccttc ttcccaccag tggagggatg   3480

tgtttctagt cttccaggga agctcctctc tcctcaaacc attttcttcc aaatactttg   3540

gctttattcc aaatcctctc tagccctctg agattttttt ataacacaaa acacaactta   3600

cagaagttgt gttgttgttt tgctgtttat cttgtcacat tatttctcta ccttgaggca   3660

acaggacaag ggcctgctgt ccagcgcacg gaggcaggga ggaaggggta ggggaatact   3720

aagaaaaaaa aatttctcga tcacatgtgt accacattta actttatcag gtccttgtga   3780

ggtgagtatc tgtgtgtcat tgttctgaaa ctaacagtga ggggacaaag cattgatagg   3840

agttcttaca atatatttgg gaactcgcag gtgagggcct ctcctgcctg attggtcttt   3900

caatgtacca tcccaaccca cccacctcaa tccccatggc ttggtcctgc tgtctcggtg   3960

atcaagcttt cagttaagaa ttgggtgata atgagctagt taatccaatt taaaaaaaaa   4020

gaattaggat ctgggctcag aagccccaca gctgtgaaag cttggccgta gattactagt   4080

cttctagatg tagaaaagat ttttcctttc tctggctatt taagtcttta tcagtcaccc   4140

tgcctcagtt atcaacacac accctagagt aaatctgttc cctgggggtg gaaatagaag   4200

gggcatgtca ttgtacatcc acactgatga aaggaaagga aacattaaga tggcttaagt   4260

ggaaaggtca catacggctt gtactagaga gacaccatgc taaagcaaaa catcgtttaa   4320

aaaaattctg acttatcatg tgctcagaaa tgctcaaatg ggtacaacca tcaccaaggg   4380

tgggatggga gggcaggggg aaaaaatatg aagcatcaaa aaaaattctg atttgtattt   4440

gtgaaattca atagtaaccc tattcattaa ctggatttta aaatcatttc aaagcacatt   4500

cggctttcaa aagatgtttg tttaaataac acagttggct tttggtcaaa aaatgaagtt   4560

tcggtaatgc atagtaacaa ctgtagtgta attactggcc acaaaatacc aggtgccaga   4620

ccaacccttt tcgaaccatt taagagaacc aagccaagca aaaatgccca gcctagcctt   4680

acccagaagt tcaaaagctc agcctttgtc tccaggaaaa aattaattca aagagcaaag   4740

ccattattcg gcacaaccag gtattctgtt gtaaacatct tttgttaata catgttgaaa   4800

gctgaacttt ctcacgtttg agtgaaagag ggctgcttaa agagagttta aaccaagcca   4860

ggttcaaggt ttttttcttt tctttctttt tagatttctg acttcatatc tgtgggatcc   4920

acacaatggg gaggtactgg ccttggaatc catggttccc cagctatcat tttactttag   4980

aattacagtg ttctctgtta gtgtcaaggg aatgaacctg acgagaaaag accaaacata   5040

ggactgttac agggaagaaa aatatgaaaa gacctaaaga tgcacgtcct cattatatgt   5100

aaggaatcta tttcctagaa tcctataaaa agctcaactg aatttgcttc agttaataaa   5160

tgtgatttaa ttataatcat aatgccacag aaaaaaaaaa aaaaaaa                 5207


<210>  1498
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  1498

Met Leu Glu Gly Val Ser Asn Glu Phe Asp His Phe Gly Ile Ser Leu 
1               5                   10                  15      


Pro Leu Lys Ile Cys Leu His Leu Gly Trp Asp Glu Gly Leu Val Glu 
            20                  25                  30          


Gly Lys Val Val Arg Leu Gly Gln Gly Ile Gly Lys Ser Ile Cys Ser 
        35                  40                  45              


Ser Cys Gln Leu Phe Glu Glu Ala Pro Thr Gln Met Ser Thr Val Pro 
    50                  55                  60                  


Ser Gly Leu Pro Leu Pro Ile Leu Met His Leu Cys Leu Leu Pro Val 
65                  70                  75                  80  


Cys Met Ala His Leu Cys Pro Ala Ser Pro Cys Tyr Phe Gly Ala Thr 
                85                  90                  95      


Pro Gly Ser Gly Lys Phe Cys Arg Leu Ile Thr Tyr Ser His Ser Ser 
            100                 105                 110         


Pro Gln Leu Ala Ala Ser Leu Arg His Arg Gly Arg Glu Val Gly Lys 
        115                 120                 125             


Asp Leu Pro Tyr Pro Gly Leu Cys Pro Leu Thr Phe His Pro Ser Phe 
    130                 135                 140                 


Phe Pro Pro Val Glu Gly Cys Val Ser Ser Leu Pro Gly Lys Leu Leu 
145                 150                 155                 160 


Ser Pro Gln Thr Ile Phe Phe Gln Ile Leu Trp Leu Tyr Ser Lys Ser 
                165                 170                 175     


Ser Leu Ala Leu 
            180 


<210>  1499
<211>  2074
<212>  DNA
<213>  Homosapiens

<400>  1499
cacaaggcgg tagccatggc ggaggcggcg gctgcagcgg gtgggactgg cttgggcgcg     60

ggcgcgagct acgggtctgc agcggaccgg gaccgggacc cggacccgga ccgcgccggg    120

cggaggctgc gggttctctc tggccatctg ctgggccggc cccgggaggc tctgagtacc    180

aatgagtgca aagcgcggag agccgcgtcg gcggccacgg cagcgcccac ggccactccc    240

gccgcgcagg agtcgggcac catcccaaag aagcggcaag aagttatgaa atggaatgga    300

tggggatata atgattctaa attcatcttc aataagaagg gccaaattga attgactggg    360

aaaaggtacc ctcttagtgg catgggttta ccaacattta aagaatggat ccaaaatacc    420

cttggagtaa atgtggagca taaaactacc tctaaagcat ccttaaatcc tagtgataca    480

cctccttctg ttgtaaatga agattttctt catgacctta aagaaactaa tatttcatat    540

tcacaagagg cagatgatcg agtatttaga gctcatggtc attgtcttca tgagatattt    600

ttgctcaggg aaggaatgtt tgagcgaatt cctgatatag ttttatggcc aacatgccat    660

gatgatgtag ttaagattgt gaatctagct tgcaaatata atctttgtat cataccaatt    720

ggtggaggaa caagtgtttc atatggcctg atgtgtcctg cagatgagac aagaacaatt    780

atttctttgg acacttcaca aatgaatcga attctctggg ttgatgagaa caatttgaca    840

gctcatgtgg aggctggcat aacaggacaa gagttggaaa gacagcttaa agaaagtggt    900

tattgtacag gtcatgaacc agattccctg gagttcagta ctgtaggagg atgggtatct    960

actcgcgcat caggcatgaa gaagaatatc tatggcaata tcgaggacct ggtggttcat   1020

ataaaaatgg taacacctag aggtataata gaaaaaagct gtcaaggacc tcgtatgtca   1080

acaggccctg atatccatca cttcatcatg ggatctgaag gaactcttgg tgtaataaca   1140

gaagctacaa taaaaatcag accagtccct gaataccaaa agtatggctc agtagctttc   1200

cctaattttg aacaaggagt agcctgttta agagaaattg caaaacagag atgtgctccg   1260

gcatctattc gcctcatgga caacaagcag tttcagtttg gtcatgctct taaacctcag   1320

gtttcctcta tctttacatc atttttggac ggattaaaaa agttttatat tacaaagttt   1380

aaaggatttg acccaaatca gctaagtgta gccacattac tgtttgaggg ggatcgtgag   1440

aaggttcttc aacatgaaaa acaagtgtat gatattgctg caaaatttgg tgggttggca   1500

gctggagaag ataatggaca gagaggttat ttgctgacct atgttattgc atacattcga   1560

gacttggctt tggaatacta tgtattagga gaatcttttg agacttctgc tccttgggac   1620

agggtggtag atctctgtag aaatgtaaaa gaaagaataa caagggaatg caaagagaag   1680

ggtgttcagt ttgctccttt ttctacatgc agggtgacgc agacttacga tgcaggtgct   1740

tgtatctact tctattttgc ctttaactac aggggaatta gtgacccact gaccgtattt   1800

gaacaaactg aggcagctgc tagagaagaa atccttgcta atggagggag cctgtcacat   1860

caccatggag tgggcaagtt acggaagcaa tggctaaagg aaagtatctc tgatgtcggc   1920

tttgggatgc tgaagtctgt caaggaatat gtggacccca ataacatctt tggaaacaga   1980

aaccttttat aaatccatta gtaccattac aaaaaaatgt caattttttt tttaagtttt   2040

caactgtggt tatactagta atcaaatata tcat                               2074


<210>  1500
<211>  658
<212>  PRT
<213>  Homosapiens

<400>  1500

Met Ala Glu Ala Ala Ala Ala Ala Gly Gly Thr Gly Leu Gly Ala Gly 
1               5                   10                  15      


Ala Ser Tyr Gly Ser Ala Ala Asp Arg Asp Arg Asp Pro Asp Pro Asp 
            20                  25                  30          


Arg Ala Gly Arg Arg Leu Arg Val Leu Ser Gly His Leu Leu Gly Arg 
        35                  40                  45              


Pro Arg Glu Ala Leu Ser Thr Asn Glu Cys Lys Ala Arg Arg Ala Ala 
    50                  55                  60                  


Ser Ala Ala Thr Ala Ala Pro Thr Ala Thr Pro Ala Ala Gln Glu Ser 
65                  70                  75                  80  


Gly Thr Ile Pro Lys Lys Arg Gln Glu Val Met Lys Trp Asn Gly Trp 
                85                  90                  95      


Gly Tyr Asn Asp Ser Lys Phe Ile Phe Asn Lys Lys Gly Gln Ile Glu 
            100                 105                 110         


Leu Thr Gly Lys Arg Tyr Pro Leu Ser Gly Met Gly Leu Pro Thr Phe 
        115                 120                 125             


Lys Glu Trp Ile Gln Asn Thr Leu Gly Val Asn Val Glu His Lys Thr 
    130                 135                 140                 


Thr Ser Lys Ala Ser Leu Asn Pro Ser Asp Thr Pro Pro Ser Val Val 
145                 150                 155                 160 


Asn Glu Asp Phe Leu His Asp Leu Lys Glu Thr Asn Ile Ser Tyr Ser 
                165                 170                 175     


Gln Glu Ala Asp Asp Arg Val Phe Arg Ala His Gly His Cys Leu His 
            180                 185                 190         


Glu Ile Phe Leu Leu Arg Glu Gly Met Phe Glu Arg Ile Pro Asp Ile 
        195                 200                 205             


Val Leu Trp Pro Thr Cys His Asp Asp Val Val Lys Ile Val Asn Leu 
    210                 215                 220                 


Ala Cys Lys Tyr Asn Leu Cys Ile Ile Pro Ile Gly Gly Gly Thr Ser 
225                 230                 235                 240 


Val Ser Tyr Gly Leu Met Cys Pro Ala Asp Glu Thr Arg Thr Ile Ile 
                245                 250                 255     


Ser Leu Asp Thr Ser Gln Met Asn Arg Ile Leu Trp Val Asp Glu Asn 
            260                 265                 270         


Asn Leu Thr Ala His Val Glu Ala Gly Ile Thr Gly Gln Glu Leu Glu 
        275                 280                 285             


Arg Gln Leu Lys Glu Ser Gly Tyr Cys Thr Gly His Glu Pro Asp Ser 
    290                 295                 300                 


Leu Glu Phe Ser Thr Val Gly Gly Trp Val Ser Thr Arg Ala Ser Gly 
305                 310                 315                 320 


Met Lys Lys Asn Ile Tyr Gly Asn Ile Glu Asp Leu Val Val His Ile 
                325                 330                 335     


Lys Met Val Thr Pro Arg Gly Ile Ile Glu Lys Ser Cys Gln Gly Pro 
            340                 345                 350         


Arg Met Ser Thr Gly Pro Asp Ile His His Phe Ile Met Gly Ser Glu 
        355                 360                 365             


Gly Thr Leu Gly Val Ile Thr Glu Ala Thr Ile Lys Ile Arg Pro Val 
    370                 375                 380                 


Pro Glu Tyr Gln Lys Tyr Gly Ser Val Ala Phe Pro Asn Phe Glu Gln 
385                 390                 395                 400 


Gly Val Ala Cys Leu Arg Glu Ile Ala Lys Gln Arg Cys Ala Pro Ala 
                405                 410                 415     


Ser Ile Arg Leu Met Asp Asn Lys Gln Phe Gln Phe Gly His Ala Leu 
            420                 425                 430         


Lys Pro Gln Val Ser Ser Ile Phe Thr Ser Phe Leu Asp Gly Leu Lys 
        435                 440                 445             


Lys Phe Tyr Ile Thr Lys Phe Lys Gly Phe Asp Pro Asn Gln Leu Ser 
    450                 455                 460                 


Val Ala Thr Leu Leu Phe Glu Gly Asp Arg Glu Lys Val Leu Gln His 
465                 470                 475                 480 


Glu Lys Gln Val Tyr Asp Ile Ala Ala Lys Phe Gly Gly Leu Ala Ala 
                485                 490                 495     


Gly Glu Asp Asn Gly Gln Arg Gly Tyr Leu Leu Thr Tyr Val Ile Ala 
            500                 505                 510         


Tyr Ile Arg Asp Leu Ala Leu Glu Tyr Tyr Val Leu Gly Glu Ser Phe 
        515                 520                 525             


Glu Thr Ser Ala Pro Trp Asp Arg Val Val Asp Leu Cys Arg Asn Val 
    530                 535                 540                 


Lys Glu Arg Ile Thr Arg Glu Cys Lys Glu Lys Gly Val Gln Phe Ala 
545                 550                 555                 560 


Pro Phe Ser Thr Cys Arg Val Thr Gln Thr Tyr Asp Ala Gly Ala Cys 
                565                 570                 575     


Ile Tyr Phe Tyr Phe Ala Phe Asn Tyr Arg Gly Ile Ser Asp Pro Leu 
            580                 585                 590         


Thr Val Phe Glu Gln Thr Glu Ala Ala Ala Arg Glu Glu Ile Leu Ala 
        595                 600                 605             


Asn Gly Gly Ser Leu Ser His His His Gly Val Gly Lys Leu Arg Lys 
    610                 615                 620                 


Gln Trp Leu Lys Glu Ser Ile Ser Asp Val Gly Phe Gly Met Leu Lys 
625                 630                 635                 640 


Ser Val Lys Glu Tyr Val Asp Pro Asn Asn Ile Phe Gly Asn Arg Asn 
                645                 650                 655     


Leu Leu 
        


<210>  1501
<211>  3766
<212>  DNA
<213>  Homosapiens

<400>  1501
tctcttcttg tacagccccg gcagccctgc cttcttggct ggagagtata ttcagggatt     60

tccccttaat aatcaccgac cctgggagca ctttttagtt tccaaaataa aaatatgatc    120

ctcacccctc ttgcttgaca gggaaaggct ctcgccggag cccagggggg agcagtagca    180

gctgcagccg agcttcctag tccattgcca gcgcctctca ctctgatctg tcagcccagc    240

cgagggaaca ggggggaagg agaaaaaaaa aagcagctga aagacaatct gcttcatcct    300

gattctgcgg cattccaaac tgtggtatcc ttgggggttc tcttaacatt gctatggtgc    360

agaagattta aaatcagctg atgttcacaa ggaatagagt cacgtgatgt atgaagggaa    420

acatatacac ttctctgagg ttgacaataa gcccttgtgc tcatatagcc ccaaactgtg    480

caagcagagg cgactcaacg gctacgcctt ctgtatcaga cacgttctgg aggacaagac    540

tgcccccttc aagcaatgtg aatatgtggc caagtataac agccaacgct gcaccaaccc    600

catccccaaa tcagaggatc gtaggtactg caacagccac ttgcaggtac ttggctttat    660

cccgaaaaaa gagaggaaga aaaagaatga tcctatagat gaggtgaagg tcaggcacca    720

gatggatacc atggccttta gcctgacagt gcccacgttg gccttgaaga tgcccaacgg    780

actggatgga atgtccctct ctccacctgg ggcaagggtc cctctccact acctggaaac    840

tgaattggaa gacccatttg ctttcaatga ggaagatgat gacctaaaga aaggggcaac    900

tgtgagaaag aagttgcaga gcaagttggc ccagaatcgg cagcgccaga gagagacaga    960

gattttaaaa gttcgacaag agcactttag tccccctcct gcaccttcac agcagcagcc   1020

tccgcagcag cactcccacc tgtcaccttt atctacttct ttaaaacctc cagcgccacc   1080

gcagggttca gtctgcaagt cacctcaacc tcagaacacc agcctaccaa tgcagggagt   1140

ggcacccacc acacacacta tagcacaagc acggcagttg tctcacaaga ggcctctgcc   1200

cctcctgcca tccagtaggg ctcccactgt ggacccaccc aggactgacc ggatcctcat   1260

gaaagccaca gccttctctc cacacttctc atgtataagc cgactgcaga gactggtgaa   1320

actgtgcacc cagaaacatc agttggacac tgatctgttt ccccatttag gtttggactg   1380

gtctgaagag agcggagagg aaccagagga ctcagagcag gcctcgccct accaggttgc   1440

atggtccatc cgggaaaccc tcagatatca aagacatgtg tcagatgatg atgatgcgga   1500

gagtaggagc tccagggtga ctcaactttg cacttacttt cagcagaaat ataagcacct   1560

ctgccgcctg gagcgggcag aatctcgtca aaagaaatgc cggcatacgt ttaggaaagc   1620

tttgctgcag gcggccagta aagaaccaga atgcactggt cagttaatac aagaactgcg   1680

gagagctgca tgcagtcgaa ccagcataag ccggaccaag ctgagggagg tggaaccagc   1740

agcatgcagt ggaaccgtga agggtgaaca gtgcgctaac aaagcccttc cattcaccag   1800

acattgtttc caacatatcc tcttgaacca ctctcagcag ctcttctcaa gttgcacagc   1860

caagtttgca gatggacagc agtgctctgt gccagttttt gacattacac atcagacacc   1920

tctgtgtgaa gaacatgcca aaaaaatgga taatttcttg agaggagata actcccgtaa   1980

agttcagcac cagcagcaga ggaaacccag gaaaaaaacc aagcctcctg cactaaccaa   2040

aaaacacaag aagaagagaa ggcgtggacc tcgtcgaccc caaaaaccca ttccacctgc   2100

agtcccccaa gggaacctca gcatgcctgc cagcgtctca ctgccagtgg aggcctctca   2160

catccggagc ccatccacgc cagagctgag tgctgatgag ttgccggatg acattgccaa   2220

tgagatcgct gacattccac atgacttgga attgaaccag gaggactttt cagatgtcct   2280

gccacggcta cctgatgact tacaagattt tgattttttt gaagggaaga atggagacct   2340

cctcccaact accgaagagg ctgaggagct tgaacgggcc ttgcaggctg taacttctct   2400

cgagtgcctg agtaccattg gggtccttgc ccagtcagat ggtgtgccag tccaggagtt   2460

gtcagataga ggaatagggg tgttctccac aggtactgga gcttcaggaa tacaatcctt   2520

gagccgagag gtgaacacag acctagggga gctattgaat gggcgtatag tacatgataa   2580

tttttctagt ctagagctgg atgagaacct gctccgttct gctaccttgt caaacccacc   2640

tacacccctg gcagggcaga tccaggggca gttctctgcc ccagccaacg ttggccttac   2700

ttctgccact ctgatcagcc agagtgcact tggggagaga gccttcccag gacagtttca   2760

tggacttcat gacggcagcc atgcctccca gaggccacat cctgcccagc tgctgagcaa   2820

ggcagatgac ctaatcacct cacgacagca atacagcagt gatcactcac actcctcacc   2880

ccatggaagc cattatgata gtgagcatgt gccgtctccc tacagtgacc atatcacctc   2940

tccccacaca acatcgtact ctggtgataa tatggcagct ccagtgtgct tccggggtta   3000

ccacagacca gcttcagtgg catggggcct tctgctgaac taatggcctc cacctctccc   3060

aagcagcaac tccctcagtt cagcgcagcc tttggccacc agctgagttc tcacagtggc   3120

attcctaagg acctgcagcc cagccacagc tctatagccc ctcctacagg cttcacagta   3180

acaggtgcca cagctacaag taccaataat gcatcttctc cctttccctc ccctaactga   3240

gggtgtctgt gtgtttgcag gcaggtgggg aacccagtgt tttctatctt tgtttcctct   3300

ttagcacccc tctccccttt tcctaaagaa gatataacag atggggatca gaggggcacc   3360

ccccttccca gttcaatgag tggccctgca gtggacctcg ctacagtgtt cacatgtgct   3420

ccttagcact ggtgctcatt ccctcctggc aggcccactc cgccccagtg gtttccttag   3480

tggttcagca cagtgactgg ataggattga tttttagcag caagtcctag aagtggaaga   3540

tacctcagaa taccagtgcc ctttactatt tcctagtatt cagatcagtg ctttccattc   3600

tgttgccagg tttttacata ggtggttcta gatagaatga tcttattaat tgagttcctg   3660

tataagagac agcaaatggt gtgtggcagg tcaagattct gacctagcac caactgctaa   3720

acaccacagt gaggccagga ttccattcgt aattgtgatc atgttt                  3766


<210>  1502
<211>  878
<212>  PRT
<213>  Homosapiens

<400>  1502

Met Tyr Glu Gly Lys His Ile His Phe Ser Glu Val Asp Asn Lys Pro 
1               5                   10                  15      


Leu Cys Ser Tyr Ser Pro Lys Leu Cys Lys Gln Arg Arg Leu Asn Gly 
            20                  25                  30          


Tyr Ala Phe Cys Ile Arg His Val Leu Glu Asp Lys Thr Ala Pro Phe 
        35                  40                  45              


Lys Gln Cys Glu Tyr Val Ala Lys Tyr Asn Ser Gln Arg Cys Thr Asn 
    50                  55                  60                  


Pro Ile Pro Lys Ser Glu Asp Arg Arg Tyr Cys Asn Ser His Leu Gln 
65                  70                  75                  80  


Val Leu Gly Phe Ile Pro Lys Lys Glu Arg Lys Lys Lys Asn Asp Pro 
                85                  90                  95      


Ile Asp Glu Val Lys Val Arg His Gln Met Asp Thr Met Ala Phe Ser 
            100                 105                 110         


Leu Thr Val Pro Thr Leu Ala Leu Lys Met Pro Asn Gly Leu Asp Gly 
        115                 120                 125             


Met Ser Leu Ser Pro Pro Gly Ala Arg Val Pro Leu His Tyr Leu Glu 
    130                 135                 140                 


Thr Glu Leu Glu Asp Pro Phe Ala Phe Asn Glu Glu Asp Asp Asp Leu 
145                 150                 155                 160 


Lys Lys Gly Ala Thr Val Arg Lys Lys Leu Gln Ser Lys Leu Ala Gln 
                165                 170                 175     


Asn Arg Gln Arg Gln Arg Glu Thr Glu Ile Leu Lys Val Arg Gln Glu 
            180                 185                 190         


His Phe Ser Pro Pro Pro Ala Pro Ser Gln Gln Gln Pro Pro Gln Gln 
        195                 200                 205             


His Ser His Leu Ser Pro Leu Ser Thr Ser Leu Lys Pro Pro Ala Pro 
    210                 215                 220                 


Pro Gln Gly Ser Val Cys Lys Ser Pro Gln Pro Gln Asn Thr Ser Leu 
225                 230                 235                 240 


Pro Met Gln Gly Val Ala Pro Thr Thr His Thr Ile Ala Gln Ala Arg 
                245                 250                 255     


Gln Leu Ser His Lys Arg Pro Leu Pro Leu Leu Pro Ser Ser Arg Ala 
            260                 265                 270         


Pro Thr Val Asp Pro Pro Arg Thr Asp Arg Ile Leu Met Lys Ala Thr 
        275                 280                 285             


Ala Phe Ser Pro His Phe Ser Cys Ile Ser Arg Leu Gln Arg Leu Val 
    290                 295                 300                 


Lys Leu Cys Thr Gln Lys His Gln Leu Asp Thr Asp Leu Phe Pro His 
305                 310                 315                 320 


Leu Gly Leu Asp Trp Ser Glu Glu Ser Gly Glu Glu Pro Glu Asp Ser 
                325                 330                 335     


Glu Gln Ala Ser Pro Tyr Gln Val Ala Trp Ser Ile Arg Glu Thr Leu 
            340                 345                 350         


Arg Tyr Gln Arg His Val Ser Asp Asp Asp Asp Ala Glu Ser Arg Ser 
        355                 360                 365             


Ser Arg Val Thr Gln Leu Cys Thr Tyr Phe Gln Gln Lys Tyr Lys His 
    370                 375                 380                 


Leu Cys Arg Leu Glu Arg Ala Glu Ser Arg Gln Lys Lys Cys Arg His 
385                 390                 395                 400 


Thr Phe Arg Lys Ala Leu Leu Gln Ala Ala Ser Lys Glu Pro Glu Cys 
                405                 410                 415     


Thr Gly Gln Leu Ile Gln Glu Leu Arg Arg Ala Ala Cys Ser Arg Thr 
            420                 425                 430         


Ser Ile Ser Arg Thr Lys Leu Arg Glu Val Glu Pro Ala Ala Cys Ser 
        435                 440                 445             


Gly Thr Val Lys Gly Glu Gln Cys Ala Asn Lys Ala Leu Pro Phe Thr 
    450                 455                 460                 


Arg His Cys Phe Gln His Ile Leu Leu Asn His Ser Gln Gln Leu Phe 
465                 470                 475                 480 


Ser Ser Cys Thr Ala Lys Phe Ala Asp Gly Gln Gln Cys Ser Val Pro 
                485                 490                 495     


Val Phe Asp Ile Thr His Gln Thr Pro Leu Cys Glu Glu His Ala Lys 
            500                 505                 510         


Lys Met Asp Asn Phe Leu Arg Gly Asp Asn Ser Arg Lys Val Gln His 
        515                 520                 525             


Gln Gln Gln Arg Lys Pro Arg Lys Lys Thr Lys Pro Pro Ala Leu Thr 
    530                 535                 540                 


Lys Lys His Lys Lys Lys Arg Arg Arg Gly Pro Arg Arg Pro Gln Lys 
545                 550                 555                 560 


Pro Ile Pro Pro Ala Val Pro Gln Gly Asn Leu Ser Met Pro Ala Ser 
                565                 570                 575     


Val Ser Leu Pro Val Glu Ala Ser His Ile Arg Ser Pro Ser Thr Pro 
            580                 585                 590         


Glu Leu Ser Ala Asp Glu Leu Pro Asp Asp Ile Ala Asn Glu Ile Ala 
        595                 600                 605             


Asp Ile Pro His Asp Leu Glu Leu Asn Gln Glu Asp Phe Ser Asp Val 
    610                 615                 620                 


Leu Pro Arg Leu Pro Asp Asp Leu Gln Asp Phe Asp Phe Phe Glu Gly 
625                 630                 635                 640 


Lys Asn Gly Asp Leu Leu Pro Thr Thr Glu Glu Ala Glu Glu Leu Glu 
                645                 650                 655     


Arg Ala Leu Gln Ala Val Thr Ser Leu Glu Cys Leu Ser Thr Ile Gly 
            660                 665                 670         


Val Leu Ala Gln Ser Asp Gly Val Pro Val Gln Glu Leu Ser Asp Arg 
        675                 680                 685             


Gly Ile Gly Val Phe Ser Thr Gly Thr Gly Ala Ser Gly Ile Gln Ser 
    690                 695                 700                 


Leu Ser Arg Glu Val Asn Thr Asp Leu Gly Glu Leu Leu Asn Gly Arg 
705                 710                 715                 720 


Ile Val His Asp Asn Phe Ser Ser Leu Glu Leu Asp Glu Asn Leu Leu 
                725                 730                 735     


Arg Ser Ala Thr Leu Ser Asn Pro Pro Thr Pro Leu Ala Gly Gln Ile 
            740                 745                 750         


Gln Gly Gln Phe Ser Ala Pro Ala Asn Val Gly Leu Thr Ser Ala Thr 
        755                 760                 765             


Leu Ile Ser Gln Ser Ala Leu Gly Glu Arg Ala Phe Pro Gly Gln Phe 
    770                 775                 780                 


His Gly Leu His Asp Gly Ser His Ala Ser Gln Arg Pro His Pro Ala 
785                 790                 795                 800 


Gln Leu Leu Ser Lys Ala Asp Asp Leu Ile Thr Ser Arg Gln Gln Tyr 
                805                 810                 815     


Ser Ser Asp His Ser His Ser Ser Pro His Gly Ser His Tyr Asp Ser 
            820                 825                 830         


Glu His Val Pro Ser Pro Tyr Ser Asp His Ile Thr Ser Pro His Thr 
        835                 840                 845             


Thr Ser Tyr Ser Gly Asp Asn Met Ala Ala Pro Val Cys Phe Arg Gly 
    850                 855                 860                 


Tyr His Arg Pro Ala Ser Val Ala Trp Gly Leu Leu Leu Asn 
865                 870                 875             


<210>  1503
<211>  3417
<212>  DNA
<213>  Homosapiens

<400>  1503
ttctccaggc ccggctgaca gagttagccg aggccgccat attgaataag cgacccggcc     60

tcctaggggg tcgtcgtggt ccagacagtt tagcagaaca gcctccgcgg ctccggggag    120

aagcaatatg ttaaggatac ctgtaagaaa ggccttagta ggcctttcta agtctcctaa    180

aggatgtgtt cgaacaactg ccacagcagc aagcaacttg attgaagtat ttgttgatgg    240

tcagtctgtc atggtggaac cgggaacgac cgtcctccaa gcttgtgaga aggttggcat    300

gcagatccct cgattctgtt atcatgaaag gttgtctgtt gctggaaact gcaggatgtg    360

ccttgttgaa attgagaaag cccctaaggt tgtagctgct tgtgccatgc cagtaatgaa    420

gggttggaat atcctaacaa actcagaaaa atccaaaaaa gccagggaag gtgtgatgga    480

gttcttatta gcaaatcacc cattggactg tcctatttgt gaccagggag gtgaatgtga    540

tctgcaggac cagtccatga tgtttggaaa tgataggagc cgatttttag aggggaagcg    600

tgctgtggaa gacaagaaca ttgggccatt ggtaaagacc atcatgacaa gatgtataca    660

gtgtactcgc tgcatcaggt ttgcaagtga gattgcagga gtagatgatt tgggaacaac    720

aggcagagga aatgatatgc aagttggcac atacattgaa aagatgttca tgtctgaact    780

gtctgggaat atcattgata tctgccctgt aggtgcccta acctctaagc cctatgcctt    840

tactgcccgg ccttgggaaa caagaaagac agaatccatt gatgtaatgg atgcggttgg    900

aagtaatatt gtggttagca caagaactgg agaagtgatg aggattttgc cacgtatgca    960

tgaggacatc aatgaagagt ggatctctga taaaaccaga tttgcctatg atgggctaaa   1020

acgtcaaaga cttaccgagc caatggtcag aaatgaaaaa gggcttttaa cctatacttc   1080

ttgggaggat gcgctctctc gcgtagctgg aatgttgcag agttttcaag gcaaagatgt   1140

ggcagcaatt gcaggtggct tggtggatgc tgaagccctg gtagctctca aagatttgct   1200

taatagagtg gactctgaca ccttatgcac tgaagaggtc ttccccactg caggagctgg   1260

cacagatttg cgttccaatt atcttcttaa tactacaatt gctggtgtgg aagaggcaga   1320

tgttgttctt ctggttggta caaacccacg ttttgaggca ccactgttta atgctagaat   1380

tcgaaagagc tggctgcata atgacttaaa agtggccctt ataggcagtc cagtggacct   1440

cacttacaca tatgaccacc tgggagactc ccccaaaatt cttcaagaca ttgcttcggg   1500

aagccatcca tttagccagg tcctaaagga agctaaaaaa ccaatggtgg ttttaggcag   1560

ttctgcactc caaagaaatg atggagcagc aattcttgca gctgtttcta gcattgcaca   1620

aaagattcgg atgactagtg gtgttactgg tgattggaaa gttatgaata tccttcatag   1680

gattgcaagt caagtagctg ctttggacct tggctataag cctggggtgg aagcaattcg   1740

gaagaaccct cccaaggtgc tgtttctcct gggagcagat ggaggttgta tcacacgaca   1800

ggatttgcca aaggattgtt tcattattta tcaaggacat catggtgatg ttggggctcc   1860

catagctgat gttattctcc caggagctgc ttacacagag aagtctgcta catatgtcaa   1920

cactgagggt agagctcagc agactaaggt agcagtgaca cctcctggct tggcaagaga   1980

agactggaaa attataagag cactctctga gattgctgga atgactcttc catatgatac   2040

tctggatcaa gtaaggaaca gattggaaga agtctctcct aatcttgttc gatatgatga   2100

tattgaaggg gctaattact tccagcaagc aaatgagctc tcaaagctag tgaaccagca   2160

gcttcttgct gacccacttg ttccacctca gctaactata aaagacttct acatgacaga   2220

ttcaattagc agagcctcac agacaatggc caaatgtgtc aaagctgtca cagagggtgc   2280

ccaggcagta gaggaaccat ccatatgctg aagcttctac taggatccca gttttgccgc   2340

agataattaa tggacaactg tagtgcagtg atcctttaca ggtttatttc tttgtaaaaa   2400

aaaataataa taatttgaat catgtaatat ttaaggttat actatgccta tttgaaaatg   2460

atattagtta tcaactttgc agtttgaaaa acatgtattg tgtgtaaagg ttaaataaca   2520

aaactatgca gatgctctta aaagcattga taacctttgt gacgaacata aagagatcct   2580

taaattatga gttgttggct tatcttcata aataatttgt ctgtaaaatg gatgaaatga   2640

aaagaggttc aattaaaacc tacttttttc tagtgctaaa gaaaagattt aagcaccttg   2700

tcaagctggg taaataggaa aaatacataa tcatgctcag atatgtatct aggataatta   2760

taattaataa taatcatagt aacaatggct aatgataatt tagctttatt atatgtgcta   2820

agcactctgg ttttacatgc attatcttct tttgttcttg ctacaaccct gtgagatagt   2880

agtattatct cattttactg atgaagactg aagcctaggt atattaaata gcttgcccaa   2940

ggccacacag caaaagtcac caactcaaac ctacttctta tttactccaa agcctgttgt   3000

tcttaactgc aacatattat ttcgtctcat taatgttgat tctataggtt gttacttcta   3060

aaaattagta ttgagtttaa tggtgaacac atttttctat tttctcttga atctgcttct   3120

ataatgtcat ggtgatttat gtggcttttt tttttttata agttatacat gtatgcatgt   3180

atacttatga gacctccctt ggaatgaggg aggtctcaag agatataatt tagattctca   3240

ttgatgttct gtattcatta tcctaacacc atctgtagtg ttaaatcaac taaattattt   3300

cagcaatagg agacaaaaca accagctttc ataattttta attgtcaaaa ccaaaaggaa   3360

tcagaataag gatcactgag aatttaaaaa aataaaaaag gaagtaaaaa ttttaca      3417


<210>  1504
<211>  727
<212>  PRT
<213>  Homosapiens

<400>  1504

Met Leu Arg Ile Pro Val Arg Lys Ala Leu Val Gly Leu Ser Lys Ser 
1               5                   10                  15      


Pro Lys Gly Cys Val Arg Thr Thr Ala Thr Ala Ala Ser Asn Leu Ile 
            20                  25                  30          


Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr 
        35                  40                  45              


Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys 
    50                  55                  60                  


Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val 
65                  70                  75                  80  


Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val 
                85                  90                  95      


Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala 
            100                 105                 110         


Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys 
        115                 120                 125             


Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met 
    130                 135                 140                 


Met Phe Gly Asn Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val 
145                 150                 155                 160 


Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys 
                165                 170                 175     


Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val 
            180                 185                 190         


Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr 
        195                 200                 205             


Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Ile Ile Asp 
    210                 215                 220                 


Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala 
225                 230                 235                 240 


Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala 
                245                 250                 255     


Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg 
            260                 265                 270         


Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp 
        275                 280                 285             


Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu 
    290                 295                 300                 


Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu 
305                 310                 315                 320 


Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Ser Phe Gln Gly Lys 
                325                 330                 335     


Asp Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val 
            340                 345                 350         


Ala Leu Lys Asp Leu Leu Asn Arg Val Asp Ser Asp Thr Leu Cys Thr 
        355                 360                 365             


Glu Glu Val Phe Pro Thr Ala Gly Ala Gly Thr Asp Leu Arg Ser Asn 
    370                 375                 380                 


Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val 
385                 390                 395                 400 


Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala 
                405                 410                 415     


Arg Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile 
            420                 425                 430         


Gly Ser Pro Val Asp Leu Thr Tyr Thr Tyr Asp His Leu Gly Asp Ser 
        435                 440                 445             


Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Ser His Pro Phe Ser Gln 
    450                 455                 460                 


Val Leu Lys Glu Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala 
465                 470                 475                 480 


Leu Gln Arg Asn Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Ser Ile 
                485                 490                 495     


Ala Gln Lys Ile Arg Met Thr Ser Gly Val Thr Gly Asp Trp Lys Val 
            500                 505                 510         


Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu 
        515                 520                 525             


Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Val 
    530                 535                 540                 


Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu 
545                 550                 555                 560 


Pro Lys Asp Cys Phe Ile Ile Tyr Gln Gly His His Gly Asp Val Gly 
                565                 570                 575     


Ala Pro Ile Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys 
            580                 585                 590         


Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val 
        595                 600                 605             


Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg 
    610                 615                 620                 


Ala Leu Ser Glu Ile Ala Gly Met Thr Leu Pro Tyr Asp Thr Leu Asp 
625                 630                 635                 640 


Gln Val Arg Asn Arg Leu Glu Glu Val Ser Pro Asn Leu Val Arg Tyr 
                645                 650                 655     


Asp Asp Ile Glu Gly Ala Asn Tyr Phe Gln Gln Ala Asn Glu Leu Ser 
            660                 665                 670         


Lys Leu Val Asn Gln Gln Leu Leu Ala Asp Pro Leu Val Pro Pro Gln 
        675                 680                 685             


Leu Thr Ile Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser 
    690                 695                 700                 


Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala 
705                 710                 715                 720 


Val Glu Glu Pro Ser Ile Cys 
                725         


<210>  1505
<211>  821
<212>  DNA
<213>  Homosapiens

<400>  1505
gcctcgaggc gggcgtcttc ggtcatctcc ggcgcttcta gggctggttc ccgtcatctt     60

cgggagccgt ggagctctcg gatacagccg acaccatggg tttcggagac ctgaaaagcc    120

ctgccggcct ccaggtgctc aacgattacc tggcggacaa gagctacatc gaggggtatg    180

tgccatcaca agcagatgtg gcagtatttg aagccgtgtc cagcccaccg cctgccgact    240

tgtgtcatgc cctacgttgg tataatcaca tcaagtctta cgaaaaggaa aaggccagcc    300

tgccaggagt gaagaaagct ttgggcaaat atggtcctgc cgatgtggaa gacactacag    360

gaagtggagc tacagatagt aaagatgatg atgacattga cctctttgga tctgatgatg    420

aggaggaaag tgaagaagca aagaggctaa gggaagaacg tcttgcacaa tatgaatcaa    480

agaaagccaa aaaacctgca cttgttgcca agtcttccat cttactagat gtgaaacctt    540

gggatgatga gacagatatg gcgaaattag aggagtgcgt cagaagcatt caagcagacg    600

gcttagtctg gggctcatct aaactagttc cagtgggata cggaattaag aaacttcaaa    660

tacagtgtgt agttgaagat gataaagttg gaacagatat gctggaggag cagatcactg    720

cttttgagga ctatgtgcag tccatggatg tggctgcttt caacaagatc taaaatccat    780

cctggatcat ggcatttaaa taaaagattg aaagattaaa a                        821


<210>  1506
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  1506

Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn 
1               5                   10                  15      


Asp Tyr Leu Ala Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Phe Glu Ala Val Ser Ser Pro Pro Pro Ala Asp 
        35                  40                  45              


Leu Cys His Ala Leu Arg Trp Tyr Asn His Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asp Val Glu Asp Thr Thr Gly Ser Gly Ala Thr Asp Ser Lys 
                85                  90                  95      


Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser 
            100                 105                 110         


Glu Glu Ala Lys Arg Leu Arg Glu Glu Arg Leu Ala Gln Tyr Glu Ser 
        115                 120                 125             


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
    130                 135                 140                 


Asp Val Lys Pro Trp Asp Asp Glu Thr Asp Met Ala Lys Leu Glu Glu 
145                 150                 155                 160 


Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys 
                165                 170                 175     


Leu Val Pro Val Gly Tyr Gly Ile Lys Lys Leu Gln Ile Gln Cys Val 
            180                 185                 190         


Val Glu Asp Asp Lys Val Gly Thr Asp Met Leu Glu Glu Gln Ile Thr 
        195                 200                 205             


Ala Phe Glu Asp Tyr Val Gln Ser Met Asp Val Ala Ala Phe Asn Lys 
    210                 215                 220                 


Ile 
225 


<210>  1507
<211>  961
<212>  DNA
<213>  Homosapiens

<400>  1507
ggacaatttg tgggccattt aattcagggc ccccaattcg tacgtggaga agtgggaatg     60

caaaagtact ttgaccttta accttcggtc cggcgcggtg gagggaaacg cctccgtctc    120

tatataagga attttccggt ctcttcgggt cctttttcct ctcttcagcg tggggcgccc    180

acaatttgcg cgctctcttt ctgctgctcc ccagctctcg gatacagccg acaccatggg    240

tttcggagac ctgaaaagcc ctgccggcct ccaggtgctc aacgattacc tggcggacaa    300

gagctacatc gaggggtatg tgccatcaca agcagatgtg gcagtatttg aagccgtgtc    360

cagcccaccg cctgccgact tgtgtcatgc cctacgttgg tataatcaca tcaagtctta    420

cgaaaaggaa aaggccagcc tgccaggagt gaagaaagct ttgggcaaat atggtcctgc    480

cgatgtggaa gacactacag gaagtggagc tacagatagt aaagatgatg atgacattga    540

cctctttgga tctgatgatg aggaggaaag tgaagaagca aagaggctaa gggaagaacg    600

tcttgcacaa tatgaatcaa agaaagccaa aaaacctgca cttgttgcca agtcttccat    660

cttactagat gtgaaacctt gggatgatga gacagatatg gcgaaattag aggagtgcgt    720

cagaagcatt caagcagacg gcttagtctg gggctcatct aaactagttc cagtgggata    780

cggaattaag aaacttcaaa tacagtgtgt agttgaagat gataaagttg gaacagatat    840

gctggaggag cagatcactg cttttgagga ctatgtgcag tccatggatg tggctgcttt    900

caacaagatc taaaatccat cctggatcat ggcatttaaa taaaagattg aaagattaaa    960

a                                                                    961


<210>  1508
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  1508

Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn 
1               5                   10                  15      


Asp Tyr Leu Ala Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Phe Glu Ala Val Ser Ser Pro Pro Pro Ala Asp 
        35                  40                  45              


Leu Cys His Ala Leu Arg Trp Tyr Asn His Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asp Val Glu Asp Thr Thr Gly Ser Gly Ala Thr Asp Ser Lys 
                85                  90                  95      


Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser 
            100                 105                 110         


Glu Glu Ala Lys Arg Leu Arg Glu Glu Arg Leu Ala Gln Tyr Glu Ser 
        115                 120                 125             


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
    130                 135                 140                 


Asp Val Lys Pro Trp Asp Asp Glu Thr Asp Met Ala Lys Leu Glu Glu 
145                 150                 155                 160 


Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys 
                165                 170                 175     


Leu Val Pro Val Gly Tyr Gly Ile Lys Lys Leu Gln Ile Gln Cys Val 
            180                 185                 190         


Val Glu Asp Asp Lys Val Gly Thr Asp Met Leu Glu Glu Gln Ile Thr 
        195                 200                 205             


Ala Phe Glu Asp Tyr Val Gln Ser Met Asp Val Ala Ala Phe Asn Lys 
    210                 215                 220                 


Ile 
225 


<210>  1509
<211>  2089
<212>  DNA
<213>  Homosapiens

<400>  1509
ataaaagtgg aatgaggaat gcagccgttc tgaacaccac cctccatttc attctggaac     60

cgggaaggta cacccaggca tgacaatagc ttctctcctc acagaaattt aactgatttc    120

ttcattctcc atttagcaag gtcatggaag atttggagga aacattattt gaagaatttg    180

aaaactattc ctatgaccta gactattact ctctggagtc tgatttggag gagaaagtcc    240

agctgggagt tgttcactgg gtctccctgg tgttatattg tttggctttt gttctgggaa    300

ttccaggaaa tgccatcgtc atttggttca cggggttcaa gtggaagaag acagtcacca    360

ctctgtggtt cctcaatcta gccattgcgg atttcatttt tcttctcttt ctgcccctgt    420

acatctccta tgtggccatg aatttccact ggccctttgg catctggctg tgcaaagcca    480

attccttcac tgcccagttg aacatgtttg ccagtgtttt tttcctgaca gtgatcagcc    540

tggaccacta tatccacttg atccatcctg tcttatctca tcggcatcga accctcaaga    600

actctctgat tgtcattata ttcatctggc ttttggcttc tctaattggc ggtcctgccc    660

tgtacttccg ggacactgtg gagttcaata atcatactct ttgctataac aattttcaga    720

agcatgatcc tgacctcact ttgatcaggc accatgttct gacttgggtg aaatttatca    780

ttggctatct cttccctttg ctaacaatga gtatttgcta cttgtgtctc atcttcaagg    840

tgaagaagcg aagcatcctg atctccagta ggcatttctg gacaattctg gttgtggttg    900

tggcctttgt ggtttgctgg actccttatc acctgtttag catttgggag ctcaccattc    960

accacaatag ctattcccac catgtgatgc aggctggaat ccccctctcc actggtttgg   1020

cattcctcaa tagttgcttg aaccccatcc tttatgtcct aattagtaag aagttccaag   1080

ctcgcttccg gtcctcagtt gctgagatac tcaagtacac actgtgggaa gtcagctgtt   1140

ctggcacagt gagtgaacag ctcaggaact cagaaaccaa gaatctgtgt ctcctggaaa   1200

cagctcaata agttattact tttccacaaa tcagtatatg gctttttatg tgggtcctct   1260

gactgatgct ttcagattaa aattgtttcc aagatagaga gccgactcca ctttcatagt   1320

tattgtttct ggtcactata taggcatcac atttttgtgt ggatatgaaa cttaggaagg   1380

atcctcttga ctccttgtga tgtggcaata aatttttttt aaaaaactga aaatacttag   1440

gaaggatccg cataattttt ttctgcaact taaatgaaat gcatcattct tgttaattat   1500

accatggtga attaatcact tttgaagcaa tatcagttat tttttgaata ataacttttc   1560

taaagcctta agtcttaata ttaaatatat gattagccag gcacggtggc tgacacctgt   1620

aatcccagca ctttgggagg ccaaggtggg gggattaccc gaggtcagga attcgagacc   1680

agcctgacca acatggagaa accccgtctc tactaaaaat acaaaattag ccggtcatgg   1740

tggtgcatgt ctgcaaaccc agctactcgg gaggctgaag caggagaatc acttgaacct   1800

gggaggcaga ggttgtggtg agccaacatc acaccattgc actccagcct gggcaacaag   1860

agtaaaactc tgtctcaaaa ataaataaat aaaatagata aataaatata tgattaacta   1920

attttaaaaa tgttaaaatg tattcttaaa ttcattttaa ttttgtacaa taacctgcta   1980

gacacatttt taaaatgcaa catgtgtact taatttcttt atgtaatcta tgtatataca   2040

tttatgaatt aaagtaattg ttggttatct taaaaaaaaa aaaaaaaaa               2089


<210>  1510
<211>  355
<212>  PRT
<213>  Homosapiens

<400>  1510

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  1511
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1511
atgcttgttc agacactgga tgtgaagtcc gattctccac tggataccca aactgcagga     60

gggttgcaac gccacgttgc cttggatgcc tgcgtgagtg gagtcgcgac tcggggcccg    120

cgtcctgaga gacgcgctcc cgcgccgctt ctcgcctccg gaccgcaggg gccgaagtcg    180

cctatttctg gctccgcggg cagcggggcc gtggcgctcg gacggtctgg gattcgggcg    240

ccgccgcgga accggaataa gaagggagag cgcccggctc ggtcctcggt ctccaccgcg    300

gcccggaagg aatccgggca gcctccgcgg agttcaacac aagatgagac acatgtgaat    360

actgggtcat cgtctgaagt ggtgcatttg gatgatgctt tttctgaaga agaggaagag    420

gatgaggata aggttgagga tgaggatgct accgaagaga gaccatccga ggtttcagaa    480

cctattgaag agttacattc cagacctcat aaatctcagg aaggcacgca ggaggtttca    540

gttcgaccat cagttattca aaaactggag aagggacagc agcagccctt ggagtttgtt    600

cataaaattg gggccagtgt gagaaaatgt aacctagtag atattggtca ggctacaaat    660

aatagaagca acttggtacg ccccccagtg atttgtaatg ctcctgctag ttgtttacct    720

gaaagctcta acgatagacc agttacagct aatacaacta gtttaccacc agcagctcat    780

ttggattcag ttagcaaatg tgacccaaac aaagttgaga aatatcttga acagccagat    840

ggggcctcta gaaatcctgt gccatcatcc catgtagaaa ctacttcatt ttcgtatcag    900

aaacataaag aatcaaatag gaaatcttta cgcatgaatt cagataagtt ggttttgtgg    960

aaagatgtaa aatctcaggg taaaacttta tcagctggct tgaaattcca tgaacgcatg   1020

ggtactaagg gctccttaag agttaaatct ccttccaaat tagcagtaaa cccgaataaa   1080

actgacatgc cttctaataa aggaatcttt gaagatacta ttgcaaagaa ccatgaggaa   1140

ttcttttcta acatggattg tacccaagaa gaaaagcatt tggtttttaa caagacagcc   1200

ttttgggaac agaagtgctc agtgagttct gaaatgaagt ttgattgtat ctctcttcag   1260

tcagcatctg atcagcccca agagactgca caagacttaa gtctttggaa ggaggagcaa   1320

attgaccaag aagataacta tgagtctaga ggttcagaaa tgagttttga ttgcagttcc   1380

tcttttcatt cactgactga ccaatctaaa gtgagtgcca aagaagtaaa cctttccaag   1440

gaagtacgta ctgatgtaca gtataagaat aataaatctt atgtttctaa aataagttct   1500

gattgtgatg acattcttca cttggttacc aaccaatccc aaatgattgt taaagaaata   1560

agtcttcaga atgcaaggca tattagcctg gttgaccaaa gctatgaatc tagtagttct   1620

gaaacgaatt ttgattgtga tgcttcacct cagtccacta gtgactaccc ccaacaatct   1680

gtaacagaag taaaccttcc taaggaagtg cacattggtt tggttgataa gaactatggt   1740

tccagtagct ctgaagtaag tgctgattct gttttcccac tgcagtcagt ggttgacaga   1800

cccccagtgg ctgtcacaga aacaaaactt cggaagaagg ctcataccag cttggttgat   1860

aactatggat cgagttgttc tgaaacaagt tttgattgtg atgtttctct tgagtcagta   1920

gttgatcatc cccaactgac tgtcaaagga agaaacctga aaggtagaca agtccaccta   1980

aaacataaga agcgtaaacc cagtagtgct aaagcacatc ttgattgtga tgtctcactt   2040

gggacagttg cagatgaatc ccagagggct gttgaaaaga taaatcttct gaaggagaag   2100

aatgctgacc ttatggatat gaactgtgaa tcccatggtc ctgaaatggg ttttcaggct   2160

gatgctcaat tagctgacca gtctcaagta gccgaaatag agcgtcagaa agtggatgtt   2220

gaccttgaga ataagagtgt tcagtctagc cgttcttctc tgagttctga ttctccggct   2280

tctctttatc attcagctca tgatgagcct caagaagctt tggatgaagt aaatcttaaa   2340

gagttaaata ttgacatgga agttaggagc tatgattgct ccagctctga gttgactttt   2400

gattctgacc cgcctcttct gtcagttact gagcagtctc atctggatgc tgaaggaaaa   2460

gaacggcaca ttgacctgga agatgagagc tgtgagtcag atagttctga aataactttt   2520

gattctgata ttcctcttta ttcagtaatt gaccaacctg aagtagctgt ttatgaggaa   2580

gaaactgttg atctggaaag taaaagtaat gaatcttgtg tctctgaaat aacttttgat   2640

tctgatattc ctcttcattc aggaaatgat caccctgaag tagctgttaa agaagtaatt   2700

cagaaagaag agtacattca cttagaaagg aagaatgatg aacccagtgg ttctgaaata   2760

agttcggatt cccatgcccc tcttcattca gtgactaatt ctcccgaagt agctgttaaa   2820

aagctaaatc ctcaaaaaga agagcaggta cacttagaaa ataaggaaaa tgaacctatt   2880

gattctgaag taagtttgga ttataatatc atttttcatt cagtgactgg acgttctgaa   2940

gatcccatta aagaaataag ccttcacaca aaagagcaca tgtacttaga aaataagagt   3000

gtttttgaaa caagtttgga ttctgatgtc cctcttcagg cagcgactca caaacctgaa   3060

gtaattgtca aagaaacatg gcttcaaaga gaaaagcacg ctgaattcca aggtagaagt   3120

actgaattca gtggttcaaa aacaagttta gattctggtg tccctcatta ttcagtaact   3180

gaacctcaag tagctgttaa caaaataaac agaaagaagc aatatgttct agaaaacaag   3240

aatgataaat gtagtggttc tgaaataatt ttggattcta atgttccacc tcagtcaatg   3300

actgaccaac ctcaactagc ttttttgaag gaaaaacatg ttaatctgaa ggacaaaaac   3360

agtaaatcag gtgattctaa aataactttt gattctgaac aacttcagga agcggttaaa   3420

aaaatagacc aatggaagga agaggttatt ggcctgaaaa ataagattaa tgaacctagt   3480

acttataaat taatacatca tcctgatgtt tctgtccaat ctgtggctga tcaacccaaa   3540

gtagctatta aacatgtgaa ccttgggaat gaaaaccata tgtacttgga agttaagaac   3600

agccaatata gttgttcaga aatgaatttg gattctggtt tcttgggtca gtcaatagtc   3660

aatcgacctc aaataactat tttggagcag gagcacattg aactagaagg taagcacaat   3720

caatgttgtg gttctgaagt aagttttgat tctgatgacc ctcttcagtc agtggctgac   3780

cggctgagag aaaccgttaa agaaataagc ctttggaagg atgaagaagt tgacacggaa   3840

gataggagaa atgaagctaa gggttttgaa attatgtatg attctgatgt tcttcagcca   3900

gtggctggcc aacctgaaga agtagttaag gaggtcagtc tttggaaaga gcatgttgac   3960

ttggaaaata agattgtcaa acctacagat tccagaataa attttgattc tcatgaaccc   4020

cttcagtccg taactaataa aattccaggg gcgaataaag aaataaatct tttgagggag   4080

gaacatgttt gtctggatga taagggctat gtgcccagtg attctgaaat aatttatgtt   4140

tcaaatatcc ctcttcagtc agtgataaaa caaccacaca ttttggaaga ggagcatgcc   4200

agtctggaag ataagagcag taattcttat agtcctgaag aaagttctga ttccaatgac   4260

tcttttcagg cagcagcaga tgagcttcaa aaacctgtca aagaaataaa tctttggaag   4320

gaagaccata tttacctgga agataagagc tataaattag gtgattttga tgtaagttat   4380

gcttctcata ttcctgttca gtttgtgact gatcaatctt ctgtacctgt caaagaaata   4440

aacttgcaaa agaaggatca taatgatcta gaaaataaga actgtgaagt ctgtggttct   4500

gaaataaaat gtcattcttg tgttcatctt cagtcagaag ttgaccaacc tcaagtgtct   4560

tacaaagagg cagaccttca gaaggaagag catgttgtca tggaagaaaa gaccgatcaa   4620

cctagtgatt cagaaatgat gtatgattct gatgttcctt ttcaaatagt agttaaccaa   4680

tttccaggat cagtcaaaga aacccacctt ccaaaggtgg tacttgtgga tctggtgccc   4740

ggtgatagtg attatgaagt aatttcagat gatattcccc ttcagttagt gactgaccca   4800

cctcagttga ctgtcaaaga tatcagctgt ataaatacag aatgtattga tatagaagat   4860

aagagctgtg acttttttgg ttctgaagtc agatgtaatt gtaaagcctc tactccctca   4920

atgacaaacc aatgcaaaga gactttcaaa ataataaacc ggaagaagga ctatattatt   4980

ctgggagagc caagttgtca atcttgtggt tctgaaatga attttaatgt tgatgcctct   5040

gatcagtcca tgacttacga gtcacaagga cctgatgaga aaatggtgaa atatattgat   5100

tcagaagata agagctgtgg atataatggt tctaaaggaa aatttaattt ggaagacact   5160

tctcatcgaa cgactcaccg actgcagaaa gctcacaaag aagccagtct tcggaaggat   5220

ccaagaaatg ctggcctaaa aggtaagagc tgtcagtcta gtgcttctgc agtggatttt   5280

ggtgcctctt ccaagtcagc gctccatcga agggctgata aaaaaaaacg ttcgaagcta   5340

aaacatagag atctagaagt gagctgtgaa ccggatggtt ttgagatgaa ttttcagtgt   5400

gctccccctc ttccatctga tactgatcag cctcaagaaa ctgttaagaa aagacaccct   5460

tgtaagaagg tatcttctga cttgaaagaa aagaaccatg attcccagtc aagctctgtt   5520

ctcaaggttg attctgtaag gaacctgaaa aaagcaaagg atgtcataga ggataatcct   5580

gatgaaccag ttcttgaagc cttgcctcat gtacctcctt catttgtggg gaaaacatgg   5640

tctcagataa tgagagaaga tgacataaaa attaatgctc tggtgaagga gtttagggaa   5700

ggtcgtttcc actgttactt tgatgatgac tgtgagacca aaaaagtttc ttcgaagggg   5760

aaaaaaaagg ttacctgggc tgacttgcaa ggtaaggagg acactgcacc aactcaagct   5820

gtgtcagaga gtgatgatat tgtctgtggt atttcagata ttgatgactt gtcagtggcc   5880

ttagataaac catgccatcg tcatcctcca gcagagaggc ctcctaagca aaaggggcgt   5940

gtggcttctc aatgccagac agcgaaaatc agccatagta ctcagaccag ttgtaagaat   6000

tacccagtga tgaaaagaaa aataattaga caagaggaag acccaccaaa aagtaagtgt   6060

tcacgtttac aggatgacag aaaaaccaaa aagaaagtca aaattgggac agttgaattt   6120

cctgcatcat gtactaaagt tttgaagcct atgcaaccca aagccttagt ctgtgttctt   6180

tcttctttaa atattaaact gaaagagggt gaaggccttc ctttccctaa aatgaggcac   6240

catagttggg ataatgatat tcggtttata tgcaaatata aacggaatat ctttgattat   6300

tatgagccct tgattaagca aattgtaatt agtcctcccc tgagtgtaat agtaccagag   6360

tttgagaggc gtaactgggt taaaattcat tttaatagga gcaaccaaaa ctccagtgca   6420

ggagataatg atgctgatgg acaaggctct gcttcagcgc ctttaatggc agtgccggca   6480

agatatggat ttaattcaca tcagggaacc agtgactctt ctctgtttct ggaagaatca   6540

aaggttctgc atgctcgtga gcttccaaag aaaagaaatt tccagctaac atttttaaat   6600

catgatgttg tcaaaatctc tccaaaatca gttagaaata agcttttgga aagtcaaagt   6660

aaaaagaaaa ttcatggaaa gagggtgaca actagtagta ataagctagg ttttcccaaa   6720

aaggtttata aaccaattat tctccagcaa aaacccagaa aagcttcaga gaaacagtca   6780

atttggattc ggaccaaacc aagtgatatc attagaaagt atatttcgaa atactctgtc   6840

tttttacgtc atagatatca gtccaggagc gcttttcttg gaaggtatct gaagaagaaa   6900

aaatctgttg tcagtaggct aaagaaggcg aagagaacag ctaaagtgct tttgaactct   6960

tcagttccac cagctggtgc cgaagagctg tcaagcgcta tggcaaatcc tcctccaaag   7020

cgacctgtgc gggcttcttg ccgcgttgca agaaggagga agaagactga tgaaagctac   7080

catggccgac agaaaggtcc ttctacacct gtgagagcat atgatctgag aagctcatct   7140

tgtttacaac aacgtgagag aatgatgact cggctagcaa acaaactgag aggtaatgag   7200

gtaaaataga agttggtttt gtgttcaggc tagttgagga ttcagtactt cagttgaaat   7260

atatttggta ctttgtgcac acagctttcc cagctttggt gagaaaacta atcttgaact   7320

attttgctat aaatattatt tttcagaatt tttatattca tttaaaatta gtgtttagag   7380

tcctttcatt ttaagattca gaaacagcct ttgtccaaca ttttctgtag aagaacttca   7440

tcttaattta tgtcacaaaa taatttagca ccgtatatag aattttgttc ctcaaatcat   7500

atccctctta ttttttatga ttatctctct catgccagca aatttaacat tgtgagaatg   7560

aatatagcaa acttattaaa aagaaggaat tataatgaat tatgtcaact tttgaatggg   7620

gttgacttaa atgaatacaa acaaaatata agttttcttt ctttttaaag cattccagaa   7680

aatgagattc cataatcttt aatacagttt ttaaaaactg gtgatttttt ttatgcatag   7740

cacaaactcc tcctgcttca tttaaattgg atctgcaagt ctctaacttt tatcatttgg   7800

acacatgcac acatacagtc tctaggtttt ttgggttagc cttattagat cttaaagggg   7860

aaaataattt tgcccatgtg tttaggcatt cccccccttt tttttaacca cctttactct   7920

cttctacatg aagagttggt ggcttaatat gaaaatccag gttattttgt ggccttatcc   7980

cctaaaaata ttttaggcat taccatatca gtttttattt ttatgtttat ttattattat   8040

tattttttga gacagagtct cactgtcttg cccaggctgg agtgcagtgg cctgaactta   8100

gctcaccgca acctccacct cccgggttca agcaattctc ctgcctaagc ctctcgagta   8160

gctgggacta caggcgtgcg ccaccatgcc cg                                 8192


<210>  1512
<211>  2402
<212>  PRT
<213>  Homosapiens

<400>  1512

Met Leu Val Gln Thr Leu Asp Val Lys Ser Asp Ser Pro Leu Asp Thr 
1               5                   10                  15      


Gln Thr Ala Gly Gly Leu Gln Arg His Val Ala Leu Asp Ala Cys Val 
            20                  25                  30          


Ser Gly Val Ala Thr Arg Gly Pro Arg Pro Glu Arg Arg Ala Pro Ala 
        35                  40                  45              


Pro Leu Leu Ala Ser Gly Pro Gln Gly Pro Lys Ser Pro Ile Ser Gly 
    50                  55                  60                  


Ser Ala Gly Ser Gly Ala Val Ala Leu Gly Arg Ser Gly Ile Arg Ala 
65                  70                  75                  80  


Pro Pro Arg Asn Arg Asn Lys Lys Gly Glu Arg Pro Ala Arg Ser Ser 
                85                  90                  95      


Val Ser Thr Ala Ala Arg Lys Glu Ser Gly Gln Pro Pro Arg Ser Ser 
            100                 105                 110         


Thr Gln Asp Glu Thr His Val Asn Thr Gly Ser Ser Ser Glu Val Val 
        115                 120                 125             


His Leu Asp Asp Ala Phe Ser Glu Glu Glu Glu Glu Asp Glu Asp Lys 
    130                 135                 140                 


Val Glu Asp Glu Asp Ala Thr Glu Glu Arg Pro Ser Glu Val Ser Glu 
145                 150                 155                 160 


Pro Ile Glu Glu Leu His Ser Arg Pro His Lys Ser Gln Glu Gly Thr 
                165                 170                 175     


Gln Glu Val Ser Val Arg Pro Ser Val Ile Gln Lys Leu Glu Lys Gly 
            180                 185                 190         


Gln Gln Gln Pro Leu Glu Phe Val His Lys Ile Gly Ala Ser Val Arg 
        195                 200                 205             


Lys Cys Asn Leu Val Asp Ile Gly Gln Ala Thr Asn Asn Arg Ser Asn 
    210                 215                 220                 


Leu Val Arg Pro Pro Val Ile Cys Asn Ala Pro Ala Ser Cys Leu Pro 
225                 230                 235                 240 


Glu Ser Ser Asn Asp Arg Pro Val Thr Ala Asn Thr Thr Ser Leu Pro 
                245                 250                 255     


Pro Ala Ala His Leu Asp Ser Val Ser Lys Cys Asp Pro Asn Lys Val 
            260                 265                 270         


Glu Lys Tyr Leu Glu Gln Pro Asp Gly Ala Ser Arg Asn Pro Val Pro 
        275                 280                 285             


Ser Ser His Val Glu Thr Thr Ser Phe Ser Tyr Gln Lys His Lys Glu 
    290                 295                 300                 


Ser Asn Arg Lys Ser Leu Arg Met Asn Ser Asp Lys Leu Val Leu Trp 
305                 310                 315                 320 


Lys Asp Val Lys Ser Gln Gly Lys Thr Leu Ser Ala Gly Leu Lys Phe 
                325                 330                 335     


His Glu Arg Met Gly Thr Lys Gly Ser Leu Arg Val Lys Ser Pro Ser 
            340                 345                 350         


Lys Leu Ala Val Asn Pro Asn Lys Thr Asp Met Pro Ser Asn Lys Gly 
        355                 360                 365             


Ile Phe Glu Asp Thr Ile Ala Lys Asn His Glu Glu Phe Phe Ser Asn 
    370                 375                 380                 


Met Asp Cys Thr Gln Glu Glu Lys His Leu Val Phe Asn Lys Thr Ala 
385                 390                 395                 400 


Phe Trp Glu Gln Lys Cys Ser Val Ser Ser Glu Met Lys Phe Asp Cys 
                405                 410                 415     


Ile Ser Leu Gln Ser Ala Ser Asp Gln Pro Gln Glu Thr Ala Gln Asp 
            420                 425                 430         


Leu Ser Leu Trp Lys Glu Glu Gln Ile Asp Gln Glu Asp Asn Tyr Glu 
        435                 440                 445             


Ser Arg Gly Ser Glu Met Ser Phe Asp Cys Ser Ser Ser Phe His Ser 
    450                 455                 460                 


Leu Thr Asp Gln Ser Lys Val Ser Ala Lys Glu Val Asn Leu Ser Lys 
465                 470                 475                 480 


Glu Val Arg Thr Asp Val Gln Tyr Lys Asn Asn Lys Ser Tyr Val Ser 
                485                 490                 495     


Lys Ile Ser Ser Asp Cys Asp Asp Ile Leu His Leu Val Thr Asn Gln 
            500                 505                 510         


Ser Gln Met Ile Val Lys Glu Ile Ser Leu Gln Asn Ala Arg His Ile 
        515                 520                 525             


Ser Leu Val Asp Gln Ser Tyr Glu Ser Ser Ser Ser Glu Thr Asn Phe 
    530                 535                 540                 


Asp Cys Asp Ala Ser Pro Gln Ser Thr Ser Asp Tyr Pro Gln Gln Ser 
545                 550                 555                 560 


Val Thr Glu Val Asn Leu Pro Lys Glu Val His Ile Gly Leu Val Asp 
                565                 570                 575     


Lys Asn Tyr Gly Ser Ser Ser Ser Glu Val Ser Ala Asp Ser Val Phe 
            580                 585                 590         


Pro Leu Gln Ser Val Val Asp Arg Pro Pro Val Ala Val Thr Glu Thr 
        595                 600                 605             


Lys Leu Arg Lys Lys Ala His Thr Ser Leu Val Asp Asn Tyr Gly Ser 
    610                 615                 620                 


Ser Cys Ser Glu Thr Ser Phe Asp Cys Asp Val Ser Leu Glu Ser Val 
625                 630                 635                 640 


Val Asp His Pro Gln Leu Thr Val Lys Gly Arg Asn Leu Lys Gly Arg 
                645                 650                 655     


Gln Val His Leu Lys His Lys Lys Arg Lys Pro Ser Ser Ala Lys Ala 
            660                 665                 670         


His Leu Asp Cys Asp Val Ser Leu Gly Thr Val Ala Asp Glu Ser Gln 
        675                 680                 685             


Arg Ala Val Glu Lys Ile Asn Leu Leu Lys Glu Lys Asn Ala Asp Leu 
    690                 695                 700                 


Met Asp Met Asn Cys Glu Ser His Gly Pro Glu Met Gly Phe Gln Ala 
705                 710                 715                 720 


Asp Ala Gln Leu Ala Asp Gln Ser Gln Val Ala Glu Ile Glu Arg Gln 
                725                 730                 735     


Lys Val Asp Val Asp Leu Glu Asn Lys Ser Val Gln Ser Ser Arg Ser 
            740                 745                 750         


Ser Leu Ser Ser Asp Ser Pro Ala Ser Leu Tyr His Ser Ala His Asp 
        755                 760                 765             


Glu Pro Gln Glu Ala Leu Asp Glu Val Asn Leu Lys Glu Leu Asn Ile 
    770                 775                 780                 


Asp Met Glu Val Arg Ser Tyr Asp Cys Ser Ser Ser Glu Leu Thr Phe 
785                 790                 795                 800 


Asp Ser Asp Pro Pro Leu Leu Ser Val Thr Glu Gln Ser His Leu Asp 
                805                 810                 815     


Ala Glu Gly Lys Glu Arg His Ile Asp Leu Glu Asp Glu Ser Cys Glu 
            820                 825                 830         


Ser Asp Ser Ser Glu Ile Thr Phe Asp Ser Asp Ile Pro Leu Tyr Ser 
        835                 840                 845             


Val Ile Asp Gln Pro Glu Val Ala Val Tyr Glu Glu Glu Thr Val Asp 
    850                 855                 860                 


Leu Glu Ser Lys Ser Asn Glu Ser Cys Val Ser Glu Ile Thr Phe Asp 
865                 870                 875                 880 


Ser Asp Ile Pro Leu His Ser Gly Asn Asp His Pro Glu Val Ala Val 
                885                 890                 895     


Lys Glu Val Ile Gln Lys Glu Glu Tyr Ile His Leu Glu Arg Lys Asn 
            900                 905                 910         


Asp Glu Pro Ser Gly Ser Glu Ile Ser Ser Asp Ser His Ala Pro Leu 
        915                 920                 925             


His Ser Val Thr Asn Ser Pro Glu Val Ala Val Lys Lys Leu Asn Pro 
    930                 935                 940                 


Gln Lys Glu Glu Gln Val His Leu Glu Asn Lys Glu Asn Glu Pro Ile 
945                 950                 955                 960 


Asp Ser Glu Val Ser Leu Asp Tyr Asn Ile Ile Phe His Ser Val Thr 
                965                 970                 975     


Gly Arg Ser Glu Asp Pro Ile Lys Glu Ile Ser Leu His Thr Lys Glu 
            980                 985                 990         


His Met Tyr Leu Glu Asn Lys Ser  Val Phe Glu Thr Ser  Leu Asp Ser 
        995                 1000                 1005             


Asp Val  Pro Leu Gln Ala Ala  Thr His Lys Pro Glu  Val Ile Val 
    1010                 1015                 1020             


Lys Glu  Thr Trp Leu Gln Arg  Glu Lys His Ala Glu  Phe Gln Gly 
    1025                 1030                 1035             


Arg Ser  Thr Glu Phe Ser Gly  Ser Lys Thr Ser Leu  Asp Ser Gly 
    1040                 1045                 1050             


Val Pro  His Tyr Ser Val Thr  Glu Pro Gln Val Ala  Val Asn Lys 
    1055                 1060                 1065             


Ile Asn  Arg Lys Lys Gln Tyr  Val Leu Glu Asn Lys  Asn Asp Lys 
    1070                 1075                 1080             


Cys Ser  Gly Ser Glu Ile Ile  Leu Asp Ser Asn Val  Pro Pro Gln 
    1085                 1090                 1095             


Ser Met  Thr Asp Gln Pro Gln  Leu Ala Phe Leu Lys  Glu Lys His 
    1100                 1105                 1110             


Val Asn  Leu Lys Asp Lys Asn  Ser Lys Ser Gly Asp  Ser Lys Ile 
    1115                 1120                 1125             


Thr Phe  Asp Ser Glu Gln Leu  Gln Glu Ala Val Lys  Lys Ile Asp 
    1130                 1135                 1140             


Gln Trp  Lys Glu Glu Val Ile  Gly Leu Lys Asn Lys  Ile Asn Glu 
    1145                 1150                 1155             


Pro Ser  Thr Tyr Lys Leu Ile  His His Pro Asp Val  Ser Val Gln 
    1160                 1165                 1170             


Ser Val  Ala Asp Gln Pro Lys  Val Ala Ile Lys His  Val Asn Leu 
    1175                 1180                 1185             


Gly Asn  Glu Asn His Met Tyr  Leu Glu Val Lys Asn  Ser Gln Tyr 
    1190                 1195                 1200             


Ser Cys  Ser Glu Met Asn Leu  Asp Ser Gly Phe Leu  Gly Gln Ser 
    1205                 1210                 1215             


Ile Val  Asn Arg Pro Gln Ile  Thr Ile Leu Glu Gln  Glu His Ile 
    1220                 1225                 1230             


Glu Leu  Glu Gly Lys His Asn  Gln Cys Cys Gly Ser  Glu Val Ser 
    1235                 1240                 1245             


Phe Asp  Ser Asp Asp Pro Leu  Gln Ser Val Ala Asp  Arg Leu Arg 
    1250                 1255                 1260             


Glu Thr  Val Lys Glu Ile Ser  Leu Trp Lys Asp Glu  Glu Val Asp 
    1265                 1270                 1275             


Thr Glu  Asp Arg Arg Asn Glu  Ala Lys Gly Phe Glu  Ile Met Tyr 
    1280                 1285                 1290             


Asp Ser  Asp Val Leu Gln Pro  Val Ala Gly Gln Pro  Glu Glu Val 
    1295                 1300                 1305             


Val Lys  Glu Val Ser Leu Trp  Lys Glu His Val Asp  Leu Glu Asn 
    1310                 1315                 1320             


Lys Ile  Val Lys Pro Thr Asp  Ser Arg Ile Asn Phe  Asp Ser His 
    1325                 1330                 1335             


Glu Pro  Leu Gln Ser Val Thr  Asn Lys Ile Pro Gly  Ala Asn Lys 
    1340                 1345                 1350             


Glu Ile  Asn Leu Leu Arg Glu  Glu His Val Cys Leu  Asp Asp Lys 
    1355                 1360                 1365             


Gly Tyr  Val Pro Ser Asp Ser  Glu Ile Ile Tyr Val  Ser Asn Ile 
    1370                 1375                 1380             


Pro Leu  Gln Ser Val Ile Lys  Gln Pro His Ile Leu  Glu Glu Glu 
    1385                 1390                 1395             


His Ala  Ser Leu Glu Asp Lys  Ser Ser Asn Ser Tyr  Ser Pro Glu 
    1400                 1405                 1410             


Glu Ser  Ser Asp Ser Asn Asp  Ser Phe Gln Ala Ala  Ala Asp Glu 
    1415                 1420                 1425             


Leu Gln  Lys Pro Val Lys Glu  Ile Asn Leu Trp Lys  Glu Asp His 
    1430                 1435                 1440             


Ile Tyr  Leu Glu Asp Lys Ser  Tyr Lys Leu Gly Asp  Phe Asp Val 
    1445                 1450                 1455             


Ser Tyr  Ala Ser His Ile Pro  Val Gln Phe Val Thr  Asp Gln Ser 
    1460                 1465                 1470             


Ser Val  Pro Val Lys Glu Ile  Asn Leu Gln Lys Lys  Asp His Asn 
    1475                 1480                 1485             


Asp Leu  Glu Asn Lys Asn Cys  Glu Val Cys Gly Ser  Glu Ile Lys 
    1490                 1495                 1500             


Cys His  Ser Cys Val His Leu  Gln Ser Glu Val Asp  Gln Pro Gln 
    1505                 1510                 1515             


Val Ser  Tyr Lys Glu Ala Asp  Leu Gln Lys Glu Glu  His Val Val 
    1520                 1525                 1530             


Met Glu  Glu Lys Thr Asp Gln  Pro Ser Asp Ser Glu  Met Met Tyr 
    1535                 1540                 1545             


Asp Ser  Asp Val Pro Phe Gln  Ile Val Val Asn Gln  Phe Pro Gly 
    1550                 1555                 1560             


Ser Val  Lys Glu Thr His Leu  Pro Lys Val Val Leu  Val Asp Leu 
    1565                 1570                 1575             


Val Pro  Gly Asp Ser Asp Tyr  Glu Val Ile Ser Asp  Asp Ile Pro 
    1580                 1585                 1590             


Leu Gln  Leu Val Thr Asp Pro  Pro Gln Leu Thr Val  Lys Asp Ile 
    1595                 1600                 1605             


Ser Cys  Ile Asn Thr Glu Cys  Ile Asp Ile Glu Asp  Lys Ser Cys 
    1610                 1615                 1620             


Asp Phe  Phe Gly Ser Glu Val  Arg Cys Asn Cys Lys  Ala Ser Thr 
    1625                 1630                 1635             


Pro Ser  Met Thr Asn Gln Cys  Lys Glu Thr Phe Lys  Ile Ile Asn 
    1640                 1645                 1650             


Arg Lys  Lys Asp Tyr Ile Ile  Leu Gly Glu Pro Ser  Cys Gln Ser 
    1655                 1660                 1665             


Cys Gly  Ser Glu Met Asn Phe  Asn Val Asp Ala Ser  Asp Gln Ser 
    1670                 1675                 1680             


Met Thr  Tyr Glu Ser Gln Gly  Pro Asp Glu Lys Met  Val Lys Tyr 
    1685                 1690                 1695             


Ile Asp  Ser Glu Asp Lys Ser  Cys Gly Tyr Asn Gly  Ser Lys Gly 
    1700                 1705                 1710             


Lys Phe  Asn Leu Glu Asp Thr  Ser His Arg Thr Thr  His Arg Leu 
    1715                 1720                 1725             


Gln Lys  Ala His Lys Glu Ala  Ser Leu Arg Lys Asp  Pro Arg Asn 
    1730                 1735                 1740             


Ala Gly  Leu Lys Gly Lys Ser  Cys Gln Ser Ser Ala  Ser Ala Val 
    1745                 1750                 1755             


Asp Phe  Gly Ala Ser Ser Lys  Ser Ala Leu His Arg  Arg Ala Asp 
    1760                 1765                 1770             


Lys Lys  Lys Arg Ser Lys Leu  Lys His Arg Asp Leu  Glu Val Ser 
    1775                 1780                 1785             


Cys Glu  Pro Asp Gly Phe Glu  Met Asn Phe Gln Cys  Ala Pro Pro 
    1790                 1795                 1800             


Leu Pro  Ser Asp Thr Asp Gln  Pro Gln Glu Thr Val  Lys Lys Arg 
    1805                 1810                 1815             


His Pro  Cys Lys Lys Val Ser  Ser Asp Leu Lys Glu  Lys Asn His 
    1820                 1825                 1830             


Asp Ser  Gln Ser Ser Ser Val  Leu Lys Val Asp Ser  Val Arg Asn 
    1835                 1840                 1845             


Leu Lys  Lys Ala Lys Asp Val  Ile Glu Asp Asn Pro  Asp Glu Pro 
    1850                 1855                 1860             


Val Leu  Glu Ala Leu Pro His  Val Pro Pro Ser Phe  Val Gly Lys 
    1865                 1870                 1875             


Thr Trp  Ser Gln Ile Met Arg  Glu Asp Asp Ile Lys  Ile Asn Ala 
    1880                 1885                 1890             


Leu Val  Lys Glu Phe Arg Glu  Gly Arg Phe His Cys  Tyr Phe Asp 
    1895                 1900                 1905             


Asp Asp  Cys Glu Thr Lys Lys  Val Ser Ser Lys Gly  Lys Lys Lys 
    1910                 1915                 1920             


Val Thr  Trp Ala Asp Leu Gln  Gly Lys Glu Asp Thr  Ala Pro Thr 
    1925                 1930                 1935             


Gln Ala  Val Ser Glu Ser Asp  Asp Ile Val Cys Gly  Ile Ser Asp 
    1940                 1945                 1950             


Ile Asp  Asp Leu Ser Val Ala  Leu Asp Lys Pro Cys  His Arg His 
    1955                 1960                 1965             


Pro Pro  Ala Glu Arg Pro Pro  Lys Gln Lys Gly Arg  Val Ala Ser 
    1970                 1975                 1980             


Gln Cys  Gln Thr Ala Lys Ile  Ser His Ser Thr Gln  Thr Ser Cys 
    1985                 1990                 1995             


Lys Asn  Tyr Pro Val Met Lys  Arg Lys Ile Ile Arg  Gln Glu Glu 
    2000                 2005                 2010             


Asp Pro  Pro Lys Ser Lys Cys  Ser Arg Leu Gln Asp  Asp Arg Lys 
    2015                 2020                 2025             


Thr Lys  Lys Lys Val Lys Ile  Gly Thr Val Glu Phe  Pro Ala Ser 
    2030                 2035                 2040             


Cys Thr  Lys Val Leu Lys Pro  Met Gln Pro Lys Ala  Leu Val Cys 
    2045                 2050                 2055             


Val Leu  Ser Ser Leu Asn Ile  Lys Leu Lys Glu Gly  Glu Gly Leu 
    2060                 2065                 2070             


Pro Phe  Pro Lys Met Arg His  His Ser Trp Asp Asn  Asp Ile Arg 
    2075                 2080                 2085             


Phe Ile  Cys Lys Tyr Lys Arg  Asn Ile Phe Asp Tyr  Tyr Glu Pro 
    2090                 2095                 2100             


Leu Ile  Lys Gln Ile Val Ile  Ser Pro Pro Leu Ser  Val Ile Val 
    2105                 2110                 2115             


Pro Glu  Phe Glu Arg Arg Asn  Trp Val Lys Ile His  Phe Asn Arg 
    2120                 2125                 2130             


Ser Asn  Gln Asn Ser Ser Ala  Gly Asp Asn Asp Ala  Asp Gly Gln 
    2135                 2140                 2145             


Gly Ser  Ala Ser Ala Pro Leu  Met Ala Val Pro Ala  Arg Tyr Gly 
    2150                 2155                 2160             


Phe Asn  Ser His Gln Gly Thr  Ser Asp Ser Ser Leu  Phe Leu Glu 
    2165                 2170                 2175             


Glu Ser  Lys Val Leu His Ala  Arg Glu Leu Pro Lys  Lys Arg Asn 
    2180                 2185                 2190             


Phe Gln  Leu Thr Phe Leu Asn  His Asp Val Val Lys  Ile Ser Pro 
    2195                 2200                 2205             


Lys Ser  Val Arg Asn Lys Leu  Leu Glu Ser Gln Ser  Lys Lys Lys 
    2210                 2215                 2220             


Ile His  Gly Lys Arg Val Thr  Thr Ser Ser Asn Lys  Leu Gly Phe 
    2225                 2230                 2235             


Pro Lys  Lys Val Tyr Lys Pro  Ile Ile Leu Gln Gln  Lys Pro Arg 
    2240                 2245                 2250             


Lys Ala  Ser Glu Lys Gln Ser  Ile Trp Ile Arg Thr  Lys Pro Ser 
    2255                 2260                 2265             


Asp Ile  Ile Arg Lys Tyr Ile  Ser Lys Tyr Ser Val  Phe Leu Arg 
    2270                 2275                 2280             


His Arg  Tyr Gln Ser Arg Ser  Ala Phe Leu Gly Arg  Tyr Leu Lys 
    2285                 2290                 2295             


Lys Lys  Lys Ser Val Val Ser  Arg Leu Lys Lys Ala  Lys Arg Thr 
    2300                 2305                 2310             


Ala Lys  Val Leu Leu Asn Ser  Ser Val Pro Pro Ala  Gly Ala Glu 
    2315                 2320                 2325             


Glu Leu  Ser Ser Ala Met Ala  Asn Pro Pro Pro Lys  Arg Pro Val 
    2330                 2335                 2340             


Arg Ala  Ser Cys Arg Val Ala  Arg Arg Arg Lys Lys  Thr Asp Glu 
    2345                 2350                 2355             


Ser Tyr  His Gly Arg Gln Lys  Gly Pro Ser Thr Pro  Val Arg Ala 
    2360                 2365                 2370             


Tyr Asp  Leu Arg Ser Ser Ser  Cys Leu Gln Gln Arg  Glu Arg Met 
    2375                 2380                 2385             


Met Thr  Arg Leu Ala Asn Lys  Leu Arg Gly Asn Glu  Val Lys 
    2390                 2395                 2400         


<210>  1513
<211>  5484
<212>  DNA
<213>  Homosapiens

<400>  1513
aattgtcagc acgggatctg agacttccaa aaaatgaagc cggcgacagg actttgggtc     60

tgggtgagcc ttctcgtggc ggcggggacc gtccagccca gcgattctca gtcagtgtgt    120

gcaggaacgg agaataaact gagctctctc tctgacctgg aacagcagta ccgagccttg    180

cgcaagtact atgaaaactg tgaggttgtc atgggcaacc tggagataac cagcattgag    240

cacaaccggg acctctcctt cctgcggtct gttcgagaag tcacaggcta cgtgttagtg    300

gctcttaatc agtttcgtta cctgcctctg gagaatttac gcattattcg tgggacaaaa    360

ctttatgagg atcgatatgc cttggcaata tttttaaact acagaaaaga tggaaacttt    420

ggacttcaag aacttggatt aaagaacttg acagaaatcc taaatggtgg agtctatgta    480

gaccagaaca aattcctttg ttatgcagac accattcatt ggcaagatat tgttcggaac    540

ccatggcctt ccaacttgac tcttgtgtca acaaatggta gttcaggatg tggacgttgc    600

cataagtcct gtactggccg ttgctgggga cccacagaaa atcattgcca gactttgaca    660

aggacggtgt gtgcagaaca atgtgacggc agatgctacg gaccttacgt cagtgactgc    720

tgccatcgag aatgtgctgg aggctgctca ggacctaagg acacagactg ctttgcctgc    780

atgaatttca atgacagtgg agcatgtgtt actcagtgtc cccaaacctt tgtctacaat    840

ccaaccacct ttcaactgga gcacaatttc aatgcaaagt acacatatgg agcattctgt    900

gtcaagaaat gtccacataa ctttgtggta gattccagtt cttgtgtgcg tgcctgccct    960

agttccaaga tggaagtaga agaaaatggg attaaaatgt gtaaaccttg cactgacatt   1020

tgcccaaaag cttgtgatgg cattggcaca ggatcattga tgtcagctca gactgtggat   1080

tccagtaaca ttgacaaatt cataaactgt accaagatca atgggaattt gatctttcta   1140

gtcactggta ttcatgggga cccttacaat gcaattgaag ccatagaccc agagaaactg   1200

aacgtctttc ggacagtcag agagataaca ggtttcctga acatacagtc atggccacca   1260

aacatgactg acttcagtgt tttttctaac ctggtgacca ttggtggaag agtactctat   1320

agtggcctgt ccttgcttat cctcaagcaa cagggcatca cctctctaca gttccagtcc   1380

ctgaaggaaa tcagcgcagg aaacatctat attactgaca acagcaacct gtgttattat   1440

cataccatta actggacaac actcttcagc acaatcaacc agagaatagt aatccgggac   1500

aacagaaaag ctgaaaattg tactgctgaa ggaatggtgt gcaaccatct gtgttccagt   1560

gatggctgtt ggggacctgg gccagaccaa tgtctgtcgt gtcgccgctt cagtagagga   1620

aggatctgca tagagtcttg taacctctat gatggtgaat ttcgggagtt tgagaatggc   1680

tccatctgtg tggagtgtga cccccagtgt gagaagatgg aagatggcct cctcacatgc   1740

catggaccgg gtcctgacaa ctgtacaaag tgctctcatt ttaaagatgg cccaaactgt   1800

gtggaaaaat gtccagatgg cttacagggg gcaaacagtt tcattttcaa gtatgctgat   1860

ccagatcggg agtgccaccc atgccatcca aactgcaccc aagggtgtaa cggtcccact   1920

agtcatgact gcatttacta cccatggacg ggccattcca ctttaccaca acatgctaga   1980

actcccctga ttgcagctgg agtaattggt gggctcttca ttctggtcat tgtgggtctg   2040

acatttgctg tttatgttag aaggaagagc atcaaaaaga aaagagcctt gagaagattc   2100

ttggaaacag agttggtgga accattaact cccagtggca cagcacccaa tcaagctcaa   2160

cttcgtattt tgaaagaaac tgagctgaag agggtaaaag tccttggctc aggtgctttt   2220

ggaacggttt ataaaggtat ttgggtacct gaaggagaaa ctgtgaagat tcctgtggct   2280

attaagattc ttaatgagac aactggtccc aaggcaaatg tggagttcat ggatgaagct   2340

ctgatcatgg caagtatgga tcatccacac ctagtccggt tgctgggtgt gtgtctgagc   2400

ccaaccatcc agctggttac tcaacttatg ccccatggct gcctgttgga gtatgtccac   2460

gagcacaagg ataacattgg atcacaactg ctgcttaact ggtgtgtcca gatagctaag   2520

ggaatgatgt acctggaaga aagacgactc gttcatcggg atttggcagc ccgtaatgtc   2580

ttagtgaaat ctccaaacca tgtgaaaatc acagattttg ggctagccag actcttggaa   2640

ggagatgaaa aagagtacaa tgctgatgga ggaaagatgc caattaaatg gatggctctg   2700

gagtgtatac attacaggaa attcacccat cagagtgacg tttggagcta tggagttact   2760

atatgggaac tgatgacctt tggaggaaaa ccctatgatg gaattccaac gcgagaaatc   2820

cctgatttat tagagaaagg agaacgtttg cctcagcctc ccatctgcac tattgacgtt   2880

tacatggtca tggtcaaatg ttggatgatt gatgctgaca gtagacctaa atttaaggaa   2940

ctggctgctg agttttcaag gatggctcga gaccctcaaa gatacctagt tattcagggt   3000

gatgatcgta tgaagcttcc cagtccaaat gacagcaagt tctttcagaa tctcttggat   3060

gaagaggatt tggaagatat gatggatgct gaggagtact tggtccctca ggctttcaac   3120

atcccacctc ccatctatac ttccagagca agaattgact cgaataggag tgaaattgga   3180

cacagccctc ctcctgccta cacccccatg tcaggaaacc agtttgtata ccgagatgga   3240

ggttttgctg ctgaacaagg agtgtctgtg ccctacagag ccccaactag cacaattcca   3300

gaagctcctg tggcacaggg tgctactgct gagatttttg atgactcctg ctgtaatggc   3360

accctacgca agccagtggc accccatgtc caagaggaca gtagcaccca gaggtacagt   3420

gctgacccca ccgtgtttgc cccagaacgg agcccacgag gagagctgga tgaggaaggt   3480

tacatgactc ctatgcgaga caaacccaaa caagaatacc tgaatccagt ggaggagaac   3540

ccttttgttt ctcggagaaa aaatggagac cttcaagcat tggataatcc cgaatatcac   3600

aatgcatcca atggtccacc caaggccgag gatgagtatg tgaatgagcc actgtacctc   3660

aacacctttg ccaacacctt gggaaaagct gagtacctga agaacaacat actgtcaatg   3720

ccagagaagg ccaagaaagc gtttgacaac cctgactact ggaaccacag cctgccacct   3780

cggagcaccc ttcagcaccc agactacctg caggagtaca gcacaaaata tttttataaa   3840

cagaatgggc ggatccggcc tattgtggca gagaatcctg aatacctctc tgagttctcc   3900

ctgaagccag gcactgtgct gccgcctcca ccttacagac accggaatac tgtggtgtaa   3960

gctcagttgt ggttttttag gtggagagac acacctgctc caatttcccc acccccctct   4020

ctttctctgg tggtcttcct tctaccccaa ggccagtagt tttgacactt cccagtggaa   4080

gatacagaga tgcaatgata gttatgtgct tacctaactt gaacattaga gggaaagact   4140

gaaagagaaa gataggagga accacaatgt ttcttcattt ctctgcatgg gttggtcagg   4200

agaatgaaac agctagagaa ggaccagaaa atgtaaggca atgctgccta ctatcaaact   4260

agctgtcact ttttttcttt ttctttttct ttctttgttt ctttcttcct cttctttttt   4320

tttttttttt taaagcagat ggttgaaaca cccatgctat ctgttcctat ctgcaggaac   4380

tgatgtgtgc atatttagca tccctggaaa tcataataaa gtttccatta gaacaaaaga   4440

ataacatttt ctataacata tgatagtgtc tgaaattgag aatccagttt ctttccccag   4500

cagtttctgt cctagcaagt aagaatggcc aactcaactt tcataattta aaaatctcca   4560

ttaaagttat aactagtaat tatgttttca acactttttg gtttttttca ttttgttttg   4620

ctctgaccga ttcctttata tttgctcccc tatttttggc tttaatttct aattgcaaag   4680

atgtttacat caaagcttct tcacagaatt taagcaagaa atattttaat atagtgaaat   4740

ggccactact ttaagtatac aatctttaaa ataagaaagg gaggctaata tttttcatgc   4800

tatcaaatta tcttcaccct catcctttac atttttcaac attttttttt ctccataaat   4860

gacactactt gataggccgt tggttgtctg aagagtagaa gggaaactaa gagacagttc   4920

tctgtggttc aggaaaacta ctgatacttt caggggtggc ccaatgaggg aatccattga   4980

actggaagaa acacactgga ttgggtatgt ctacctggca gatactcaga aatgtagttt   5040

gcacttaagc tgtaatttta tttgttcttt ttctgaactc cattttggat tttgaatcaa   5100

gcaatatgga agcaaccagc aaattaacta atttaagtac atttttaaaa aaagagctaa   5160

gataaagact gtggaaatgc caaaccaagc aaattaggaa ccttgcaacg gtatccaggg   5220

actatgatga gaggccagca cattatcttc atatgtcacc tttgctacgc aaggaaattt   5280

gttcagttcg tatacttcgt aagaaggaat gcgagtaagg attggcttga attccatgga   5340

atttctagta tgagactatt tatatgaagt agaaggtaac tctttgcaca taaattggta   5400

taataaaaag aaaaacacaa acattcaaag cttagggata ggtccttggg tcaaaagttg   5460

taaataaatg tgaaacatct tctc                                          5484


<210>  1514
<211>  1308
<212>  PRT
<213>  Homosapiens

<400>  1514

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210>  1515
<211>  8050
<212>  DNA
<213>  Homosapiens

<400>  1515
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg     60

agctttccag ccgggctccc agagcgcgct gcgcaggaga cgcggtggcc tgagagcctg    120

agggtccccg gactcgccca ggctctgagc tctctcccac catgagcgcc cggaccgccc    180

ccaggccgca ggtgctcctg ctgccgctcc tgctggtgct cctggcggcg gcgcccgcag    240

ccagcaaggg ttgtgtctgt aaagacaaag gccagtgctt ctgtgacggg gccaaagggg    300

agaaggggga gaagggcttt cctggacccc ccggttctcc tggccagaaa ggattcacag    360

gtcctgaagg cttgcctgga ccgcagggac ccaagggctt tccaggactt ccaggactca    420

cgggttccaa aggtgtaagg ggaataagtg gattgccagg attttctggt tctcctggac    480

ttccaggcac cccaggcaat accgggcctt acggacttgt cggtgtacca ggatgcagtg    540

gttctaaggg tgagcagggg tttccaggac tcccagggac accgggctac ccagggatcc    600

cgggtgctgc tggtttgaaa ggacaaaagg gtgctcctgc taaaggagaa gatatagaac    660

ttgatgcaaa aggcgacccc gggttgccag gggctccagg accccagggt ttgccaggcc    720

ctccaggttt tcctgggcct gttggcccac ctggtcctcc gggattcttt ggctttccag    780

gagccatggg acctagagga cctaagggtc acatgggtga aagagtgata ggacataaag    840

gagagcgggg tgtgaaaggg ttaacaggac ccccgggacc accaggaaca gttattgtga    900

ccctaactgg cccagataac agaacggacc tcaaggggga aaagggagac aagggagcaa    960

tgggcgagcc tggacctcct ggaccctcag gactgcctgg agaatcatat ggatctgaaa   1020

agggtgctcc tggagaccct ggcctgcagg gaaaacccgg aaaagatggt gttcctggct   1080

tccctggaag tgagggagtc aagggcaaca ggggtttccc tgggttaatg ggtgaagatg   1140

gcattaaggg acagaaaggg gacattggcc ctccaggatt tcgtggtcca acagaatatt   1200

atgacacata ccaggaaaag ggagatgaag gcactccagg cccaccaggg cccagaggag   1260

ctcgtggccc acaaggtccc agtggtcccc ccggagttcc tggaagtcct ggatcatcaa   1320

ggcctggcct cagaggagcc cctggatggc caggcttgaa aggaagtaaa ggggaacgag   1380

gccgcccagg aaaggatgcc atggggactc ctgggtcccc aggttgtgct ggttcaccag   1440

gtcttccagg atcaccggga cctccaggac cgccaggtga catcgttttt cgcaagggtc   1500

cacctggaga tcacggactg ccaggctatc tagggtctcc aggaatccca ggagttgatg   1560

ggcccaaagg agaaccaggc ctcctgtgta cacagtgccc ttatatccca gggcctcccg   1620

gtctcccagg attgccaggg ttacatggtg taaaaggaat cccaggaaga caaggcgcag   1680

ctggcttgaa aggaagccca gggtccccag gaaatacagg tcttccagga tttccaggtt   1740

tcccaggtgc ccagggtgac ccaggactta aaggagaaaa aggtgaaaca cttcagcctg   1800

aggggcaagt gggtgtccca ggtgacccgg ggctcagagg ccaacctggg agaaagggct   1860

tggatggaat tcctggaact ctgggagtga aaggattacc aggacctaaa ggcgaactgg   1920

ctctgagtgg tgagaaaggg gaccaaggtc ctccagggga tcctggctcc cctgggtccc   1980

caggacctgc aggaccagct ggaccacctg gctacggacc ccaaggagaa cctggtctcc   2040

agggcacgca aggagttcct ggggcccccg gaccacccgg agaagccggc cctaggggag   2100

agctcagtgt ttcaacacca gttccaggcc ctccaggacc tccagggccc cctggccatc   2160

ctggccccca aggtccacct ggtatccctg gatccctggg gaaatgtgga gatcctggtc   2220

ttccagggcc tgatggtgaa ccaggaattc caggaattgg atttcctggg ccacctggac   2280

ctaagggaga ccaaggtttt ccaggtacaa aaggatcact gggttgtcct ggaaaaatgg   2340

gagagcctgg gttacctgga aagccaggcc tcccaggagc caagggagaa ccagcagtag   2400

ccatgcctgg aggaccagga acaccaggtt ttccaggaga aagaggcaat tctggggaac   2460

atggagaaat tggactccct ggacttccag gtctccctgg aactccagga aatgaagggc   2520

ttgatggacc acgaggagat ccagggcagc ctggaccacc tggagaacaa ggacccccag   2580

gaaggtgcat agagggtccc aggggagccc aaggacttcc aggcttaaat ggattgaaag   2640

ggcaacaagg cagaagaggt aaaacggggc caaagggaga cccaggaatt ccaggcttgg   2700

atagatcagg atttcctgga gaaactggat caccaggaat tccaggtcat caaggtgaaa   2760

tgggaccact gggtcaaaga ggatatccag gaaatccggg aattttaggg ccaccaggtg   2820

aagatggagt gattgggatg atgggatttc ctggagccat tggccctcca gggccccctg   2880

ggaacccagg cacaccaggg cagaggggga gccctggaat tccaggagta aagggccaga   2940

gaggaacccc aggagccaag ggggaacaag gagataaagg aaatcccggg ccttcagaga   3000

tatcccacgt aataggggac aaaggagaac caggtctcaa aggattcgca ggaaatccag   3060

gtgagaaagg aaacagaggc gttccaggga tgccaggttt aaagggcctc aaaggactac   3120

ccggaccagc aggaccacca ggccccagag gagatttggg cagcactggg aatcctggag   3180

aaccaggact ccgtggtata ccaggaagca tggggaacat gggcatgcca ggttctaaag   3240

gaaaaagggg aactttggga ttcccaggtc gagcaggaag accaggcctc ccaggtattc   3300

atggtctcca gggagataag ggagagccag gttattcaga aggtacaagg ccaggaccac   3360

cgggaccaac gggggatcca ggactgccgg gtgatatggg aaagaaagga gaaatggggc   3420

aacctggccc acctggacat ttggggcctg ctggacctga gggagcccct ggaagtcctg   3480

gaagtcctgg cctcccagga aagccaggtc ctcatggtga tttgggtttt aaaggaatca   3540

aaggcctcct gggccctcca ggaatcagag gccctccagg tcttccagga tttccaggat   3600

ctcctggacc aatgggtata agaggtgacc aaggacgtga tggaattcct ggtccagccg   3660

gagaaaaggg agaaacgggt ttattgaggg cccctccagg cccaagaggg aaccctggtg   3720

ctcaaggagc caaaggagac aggggagccc caggttttcc tggcctcccg ggcagaaaag   3780

gggccatggg agatgctgga cctcgaggac ccacaggcat agaaggattc ccagggccac   3840

caggtctgcc cggtgcaatt atccctggcc agacaggaaa tcgtggtcca ccaggctcaa   3900

gaggaagccc aggtgcgcct ggtccccctg gacctccagg gagtcatgta ataggcataa   3960

aaggagacaa agggtctatg ggccaccctg gcccaaaagg tccacctgga actgcaggag   4020

acatgggacc accaggtcgt ctgggagcac caggtactcc aggtcttcca ggacccagag   4080

gtgatcctgg attccagggg tttccaggcg tgaaaggaga aaagggtaat cctggatttc   4140

taggatccat tggacctcca ggaccaattg ggccaaaagg accacctggt gtacgtggag   4200

accctggcac acttaagatt atctcccttc caggaagccc agggccacct ggcacacctg   4260

gagaaccagg gatgcaggga gaacctgggc caccagggcc acctggaaac ctaggaccct   4320

gtgggccaag aggtaagcca ggcaaggatg gaaaaccagg aactcctgga ccagctggag   4380

aaaaaggcaa caaaggttct aaaggagagc caggaccagc tggatcagat ggattgccag   4440

gtttgaaagg aaaacgtgga gacagtggat cacctgcaac ctggacaacg agaggctttg   4500

tcttcacccg acacagtcaa accacagcaa ttccttcatg tccagagggg acagtgccac   4560

tctacagtgg gttttctttt ctttttgtac aaggaaatca acgagcccac ggacaagacc   4620

ttggaactct tggcagctgc ctgcagcgat ttaccacaat gccattctta ttctgcaatg   4680

tcaatgatgt atgtaatttt gcatctcgaa atgattattc atactggctg tcaacaccag   4740

ctctgatgcc aatgaacatg gctcccatta ctggcagagc ccttgagcct tatataagca   4800

gatgcactgt ttgtgaaggt cctgcgatcg ccatagccgt tcacagccaa accactgaca   4860

ttcctccatg tcctcacggc tggatttctc tctggaaagg attttcattc atcatgttca   4920

caagtgcagg ttctgagggc accgggcaag cactggcctc ccctggctcc tgcctggaag   4980

aattccgagc cagcccattt ctagaatgtc atggaagagg aacgtgcaac tactattcaa   5040

attcctacag tttctggctg gcttcattaa acccagaaag aatgttcaga aagcctattc   5100

catcaactgt gaaagctggg gaattagaaa aaataataag tcgctgtcag gtgtgcatga   5160

agaaaagaca ctgaagctaa aaaagacatg cagaactgct atttttcatc ctaaagaaca   5220

aagtaatgac agaacatgct gttatttagg tatttttctt taaccaaaca atattgctcc   5280

atgatgactt agtacaaagt ttcaatttgt ttccccacaa aacaaagcaa ttctttcaag   5340

tgcagttctg tgatctgggt ctctaatctg tgctgtttca aagttctctg tggcaaagca   5400

gcaactattc acaaaatatc accaaaaacc tattccactt acatccaagg cactgtcact   5460

acggtgattg tatgaagttt gaatgctgca cgttatgaaa tatttggccc gctggattcc   5520

cacatttgtc ttctttctgt ctttaagact cagggaggct aaatcagtgt ttgattgccc   5580

cgccaaccct tcctgaaact tcagaccctg ggtagggaag agaaggggca tgtggtatct   5640

ggagcattgt gtatagaact ggattttcag acctgctgag gaccgtaagg cctgatggaa   5700

cacagaactg aactgaggtt catggatttt ccaggactgt ttcaaacatg cccattacta   5760

acggcaaaag ggggattccc tgatggaacc ataataccct tggaaatact gtatggtttt   5820

gttttgtttt gttggttttt aaagattttt gtttgtttat tgaattcatt cactgtagct   5880

ctaaaatctg cttgtatcca agcatataaa attttccccc ttagtgaatt agttttaaaa   5940

tgatattgtt atatacatac tatgaaatat gtataacttt aacttctgtt ttaccagcat   6000

acgcacacaa ataacaagaa tactacttat gaaatgtgca ctttatcctc attccataaa   6060

tgttggtgca taccttatgt aagggagcag ttcaataatc catgaaagaa cttaaggcat   6120

ttgttggttt atcagactcg gaatctattt ttctcattgc tctgaatatg tcatcactct   6180

aggttttaca gatttattcc tttgttactt ctctaattct tcctttgtaa aaaaaaaaaa   6240

agcaacactt ttttttatgt tatatgttgt cttacaaacc atactgaaag agtcattgtt   6300

taaaatctta atgtatcaaa ctgtataact tggccgctgt atgtcttaaa acctgctttt   6360

caatgtgttg atacattccc aaggttactt aattcaactt aactatcatg ttattcagca   6420

ccaagcatgt ccaggcactg tactaaccta cagagatgct aagagaaaaa aaagacttgt   6480

ttctgatcta atatccagaa aaagtaactc attgctctgt aataatctca catatacagt   6540

agcttcctcc ctctagtttt ttcttccttg tcactgctgt tatatttcat catgataatt   6600

cagcaggcca gtaaggtaaa aataaggtct atgcctaggg aaactcaggc ttctagtttc   6660

tcttagaaaa gctaagagaa gataaggtct gaataatagc agaaaaacca acatctacaa   6720

aacattaaac tagtgttata ccttgatgat aacactattg atgagtctta gagtccagac   6780

acaaagagac aaagctttga agatgctttt gatctaccta ggtggagttg gtggtgctga   6840

tatttaaatt caggctactg cttcaatctc aattgctttg taagtgaaaa catgacccag   6900

agacagacag actatggcca tggctcacat ggtttacatc cttcactgct cacgtgtttg   6960

ctgtcaagcc atttttacag tctgaaacta agatgtgcag catttcactt atttagattc   7020

acttaacaaa caaatttttc tgctttaaaa atgtcttatt gtcccaaggt actatagcgg   7080

atatagagct agctaatctc tacaaaccct ctgtaggcca gtagttctca aagtgtggtc   7140

tctggaagag cagtatcagc atcatctggg aacttgtcac agatgcagat tctagggacc   7200

actccagacc tacagaatca gaaactcttg ggggagggcc cgaaatatct atgttttacc   7260

aagcccacca catgattctg atgtactcta aatactgaga aaacctgttc tatcaatcca   7320

agcacactcc gcaggcagtt accagtacgg ctggctacaa ctgctccatc cgtgcctctt   7380

tttaaagttc aaactcacag gtgactctaa ggttatctac ttttactcat aagtaaaagc   7440

cctagactgg tgctaatgtc aaaccactgg cctccactca ggcctccatc ttctcatgcc   7500

ctcttaccag tatttaactt ctgaggaaga caagtgatgc taaaacctga attccaatga   7560

agccatatga accagctgtc agttgcactt ctaagacttt acttagcagt aaattatagc   7620

tcatgtgcat tatttcagat acttagctta tgagtagctt atacaattag tgaagattaa   7680

tattacagat taaatgtaac tgttcttaaa ttgggctcac ttgattcaca gcgtgcatac   7740

acagattgtg agaagtcttc agcaagataa acattattaa ctaacttatt tatgaagtat   7800

taaaatgctt acatttgaac ttgatggcta acttactaag attctctatg tatcaaatgt   7860

aacttactgc gactaaactt aatttaatat ttactctata accaaatgaa atatatttaa   7920

aatatattga atattttata ttgttatatc ctgacaagat tgttaatatt ttaatgtact   7980

aatatttctg tcaattatat ctaaatatta ttttattata ttgcctaaga ataaacattt   8040

gttaaattgg                                                          8050


<210>  1516
<211>  1670
<212>  PRT
<213>  Homosapiens

<400>  1516

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Thr Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Thr Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Thr Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210>  1517
<211>  7872
<212>  DNA
<213>  Homosapiens

<400>  1517
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg     60

agctttccag ccgggctccc agagcgcgct gcgcaggaga cgcggtggcc tgagagcctg    120

agggtccccg gactcgccca ggctctgagc tctctcccac catgagcgcc cggaccgccc    180

ccaggccgca ggtgctcctg ctgccgctcc tgctggtgct cctggcggcg gcgcccgcag    240

ccagcaaggg ttgtgtctgt aaagacaaag gccagtgctt ctgtgacggg gccaaagggg    300

agaaggggga gaagggcttt cctggacccc ccggttctcc tggccagaaa ggattcacag    360

gtcctgaagg cttgcctgga ccgcagggac ccaagggctt tccaggactt ccaggactca    420

cgggttccaa aggtgtaagg ggaataagtg gattgccagg attttctggt tctcctggac    480

ttccaggcac cccaggcaat accgggcctt acggacttgt cggtgtacca ggatgcagtg    540

gttctaaggg tgagcagggg tttccaggac tcccagggac accgggctac ccagggatcc    600

cgggtgctgc tggtttgaaa ggacaaaagg gtgctcctgc taaaggagaa gatatagaac    660

ttgatgcaaa aggcgacccc gggttgccag gggctccagg accccagggt ttgccaggcc    720

ctccaggttt tcctgggcct gttggcccac ctggtcctcc gggattcttt ggctttccag    780

gagccatggg acctagagga cctaagggtc acatgggtga aagagtgata ggacataaag    840

gagagcgggg tgtgaaaggg ttaacaggac ccccgggacc accaggaaca gttattgtga    900

ccctaactgg cccagataac agaacggacc tcaaggggga aaagggagac aagggagcaa    960

tgggcgagcc tggacctcct ggaccctcag gactgcctgg agaatcatat ggatctgaaa   1020

agggtgctcc tggagaccct ggcctgcagg gaaaacccgg aaaagatggt gttcctggct   1080

tccctggaag tgagggagtc aagggcaaca ggggtttccc tgggttaatg ggtgaagatg   1140

gcattaaggg acagaaaggg gacattggcc ctccaggatt tcgtggtcca acagaatatt   1200

atgacacata ccaggaaaag ggagatgaag gcactccagg cccaccaggg cccagaggag   1260

ctcgtggccc acaaggtccc agtggtcccc ccggagttcc tggaagtcct ggatcatcaa   1320

ggcctggcct cagaggagcc cctggatggc caggcttgaa aggaagtaaa ggggaacgag   1380

gccgcccagg aaaggatgcc atggggactc ctgggtcccc aggttgtgct ggttcaccag   1440

gtcttccagg atcaccggga cctccaggac cgccaggtga catcgttttt cgcaagggtc   1500

cacctggaga tcacggactg ccaggctatc tagggtctcc aggaatccca ggagttgatg   1560

ggcccaaagg agaaccaggc ctcctgtgta cacagtgccc ttatatccca gggcctcccg   1620

gtctcccagg attgccaggg ttacatggtg taaaaggaat cccaggaaga caaggcgcag   1680

ctggcttgaa aggaagccca gggtccccag gaaatacagg tcttccagga tttccaggtt   1740

tcccaggtgc ccagggtgac ccaggactta aaggagaaaa aggtgaaaca cttcagcctg   1800

aggggcaagt gggtgtccca ggtgacccgg ggctcagagg ccaacctggg agaaagggct   1860

tggatggaat tcctggaact ctgggagtga aaggattacc aggacctaaa ggcgaactgg   1920

ctctgagtgg tgagaaaggg gaccaaggtc ctccagggga tcctggctcc cctgggtccc   1980

caggacctgc aggaccagct ggaccacctg gctacggacc ccaaggagaa cctggtctcc   2040

agggcacgca aggagttcct ggggcccccg gaccacccgg agaagccggc cctaggggag   2100

agctcagtgt ttcaacacca gttccaggcc ctccaggacc tccagggccc cctggccatc   2160

ctggccccca aggtccacct ggtatccctg gatccctggg gaaatgtgga gatcctggtc   2220

ttccagggcc tgatggtgaa ccaggaattc caggaattgg atttcctggg ccacctggac   2280

ctaagggaga ccaaggtttt ccaggtacaa aaggatcact gggttgtcct ggaaaaatgg   2340

gagagcctgg gttacctgga aagccaggcc tcccaggagc caagggagaa ccagcagtag   2400

ccatgcctgg aggaccagga acaccaggtt ttccaggaga aagaggcaat tctggggaac   2460

atggagaaat tggactccct ggacttccag gtctccctgg aactccagga aatgaagggc   2520

ttgatggacc acgaggagat ccagggcagc ctggaccacc tggagaacaa ggacccccag   2580

gaaggtgcat agagggtccc aggggagccc aaggacttcc aggcttaaat ggattgaaag   2640

ggcaacaagg cagaagaggt aaaacggggc caaagggaga cccaggaatt ccaggcttgg   2700

atagatcagg atttcctgga gaaactggat caccaggaat tccaggtcat caaggtgaaa   2760

tgggaccact gggtcaaaga ggatatccag gaaatccggg aattttaggg ccaccaggtg   2820

aagatggagt gattgggatg atgggatttc ctggagccat tggccctcca gggccccctg   2880

ggaacccagg cacaccaggg cagaggggga gccctggaat tccaggagta aagggccaga   2940

gaggaacccc aggagccaag ggggaacaag gagataaagg aaatcccggg ccttcagaga   3000

tatcccacgt aataggggac aaaggagaac caggtctcaa aggattcgca ggaaatccag   3060

gtgagaaagg aaacagaggc gttccaggga tgccaggttt aaagggcctc aaaggactac   3120

ccggaccagc aggaccacca ggccccagag gagatttggg cagcactggg aatcctggag   3180

aaccaggact ccgtggtata ccaggaagca tggggaacat gggcatgcca ggttctaaag   3240

gaaaaagggg aactttggga ttcccaggtc gagcaggaag accaggcctc ccaggtattc   3300

atggtctcca gggagataag ggagagccag gttattcaga aggtacaagg ccaggaccac   3360

cgggaccaac gggggatcca ggactgccgg gtgatatggg aaagaaagga gaaatggggc   3420

aacctggccc acctggacat ttggggcctg ctggacctga gggagcccct ggaagtcctg   3480

gaagtcctgg cctcccagga aagccaggtc ctcatggtga tttgggtttt aaaggaatca   3540

aaggcctcct gggccctcca ggaatcagag gccctccagg tcttccagga tttccaggat   3600

ctcctggacc aatgggtata agaggtgacc aaggacgtga tggaattcct ggtccagccg   3660

gagaaaaggg agaaacgggt ttattgaggg cccctccagg cccaagaggg aaccctggtg   3720

ctcaaggagc caaaggagac aggggagccc caggttttcc tggcctcccg ggcagaaaag   3780

gggccatggg agatgctgga cctcgaggac ccacaggcat agaaggattc ccagggccac   3840

caggtctgcc cggtgcaatt atccctggcc agacaggaaa tcgtggtcca ccaggctcaa   3900

gaggaagccc aggtgcgcct ggtccccctg gacctccagg gagtcatgta ataggcataa   3960

aaggagacaa agggtctatg ggccaccctg gcccaaaagg tccacctgga actgcaggag   4020

acatgggacc accaggtcgt ctgggagcac caggtactcc aggtcttcca ggacccagag   4080

gtgatcctgg attccagggg tttccaggcg tgaaaggaga aaagggtaat cctggatttc   4140

taggatccat tggacctcca ggaccaattg ggccaaaagg accacctggt gtacgtggag   4200

accctggcac acttaagatt atctcccttc caggaagccc agggccacct ggcacacctg   4260

gagaaccagg gatgcaggga gaacctgggc caccagggcc acctggaaac ctaggaccct   4320

gtgggccaag aggtaagcca ggcaaggatg gaaaaccagg aactcctgga ccagctggag   4380

aaaaaggcaa caaaggttct aaaggagagc caggaccagc tggatcagat ggattgccag   4440

gtttgaaagg aaaacgtgga gacagtggat cacctgcaac ctggacaacg agaggctttg   4500

tcttcacccg acacagtcaa accacagcaa ttccttcatg tccagagggg acagtgccac   4560

tctacagtgg gttttctttt ctttttgtac aaggaaatca acgagcccac ggacaagacc   4620

ttgatgcact gtttgtgaag gtcctgcgat cgccatagcc gttcacagcc aaaccactga   4680

cattcctcca tgtcctcacg gctggatttc tctctggaaa ggattttcat tcatcatgtt   4740

cacaagtgca ggttctgagg gcaccgggca agcactggcc tcccctggct cctgcctgga   4800

agaattccga gccagcccat ttctagaatg tcatggaaga ggaacgtgca actactattc   4860

aaattcctac agtttctggc tggcttcatt aaacccagaa agaatgttca gaaagcctat   4920

tccatcaact gtgaaagctg gggaattaga aaaaataata agtcgctgtc aggtgtgcat   4980

gaagaaaaga cactgaagct aaaaaagaca tgcagaactg ctatttttca tcctaaagaa   5040

caaagtaatg acagaacatg ctgttattta ggtatttttc tttaaccaaa caatattgct   5100

ccatgatgac ttagtacaaa gtttcaattt gtttccccac aaaacaaagc aattctttca   5160

agtgcagttc tgtgatctgg gtctctaatc tgtgctgttt caaagttctc tgtggcaaag   5220

cagcaactat tcacaaaata tcaccaaaaa cctattccac ttacatccaa ggcactgtca   5280

ctacggtgat tgtatgaagt ttgaatgctg cacgttatga aatatttggc ccgctggatt   5340

cccacatttg tcttctttct gtctttaaga ctcagggagg ctaaatcagt gtttgattgc   5400

cccgccaacc cttcctgaaa cttcagaccc tgggtaggga agagaagggg catgtggtat   5460

ctggagcatt gtgtatagaa ctggattttc agacctgctg aggaccgtaa ggcctgatgg   5520

aacacagaac tgaactgagg ttcatggatt ttccaggact gtttcaaaca tgcccattac   5580

taacggcaaa agggggattc cctgatggaa ccataatacc cttggaaata ctgtatggtt   5640

ttgttttgtt ttgttggttt ttaaagattt ttgtttgttt attgaattca ttcactgtag   5700

ctctaaaatc tgcttgtatc caagcatata aaattttccc ccttagtgaa ttagttttaa   5760

aatgatattg ttatatacat actatgaaat atgtataact ttaacttctg ttttaccagc   5820

atacgcacac aaataacaag aatactactt atgaaatgtg cactttatcc tcattccata   5880

aatgttggtg cataccttat gtaagggagc agttcaataa tccatgaaag aacttaaggc   5940

atttgttggt ttatcagact cggaatctat ttttctcatt gctctgaata tgtcatcact   6000

ctaggtttta cagatttatt cctttgttac ttctctaatt cttcctttgt aaaaaaaaaa   6060

aaagcaacac ttttttttat gttatatgtt gtcttacaaa ccatactgaa agagtcattg   6120

tttaaaatct taatgtatca aactgtataa cttggccgct gtatgtctta aaacctgctt   6180

ttcaatgtgt tgatacattc ccaaggttac ttaattcaac ttaactatca tgttattcag   6240

caccaagcat gtccaggcac tgtactaacc tacagagatg ctaagagaaa aaaaagactt   6300

gtttctgatc taatatccag aaaaagtaac tcattgctct gtaataatct cacatataca   6360

gtagcttcct ccctctagtt ttttcttcct tgtcactgct gttatatttc atcatgataa   6420

ttcagcaggc cagtaaggta aaaataaggt ctatgcctag ggaaactcag gcttctagtt   6480

tctcttagaa aagctaagag aagataaggt ctgaataata gcagaaaaac caacatctac   6540

aaaacattaa actagtgtta taccttgatg ataacactat tgatgagtct tagagtccag   6600

acacaaagag acaaagcttt gaagatgctt ttgatctacc taggtggagt tggtggtgct   6660

gatatttaaa ttcaggctac tgcttcaatc tcaattgctt tgtaagtgaa aacatgaccc   6720

agagacagac agactatggc catggctcac atggtttaca tccttcactg ctcacgtgtt   6780

tgctgtcaag ccatttttac agtctgaaac taagatgtgc agcatttcac ttatttagat   6840

tcacttaaca aacaaatttt tctgctttaa aaatgtctta ttgtcccaag gtactatagc   6900

ggatatagag ctagctaatc tctacaaacc ctctgtaggc cagtagttct caaagtgtgg   6960

tctctggaag agcagtatca gcatcatctg ggaacttgtc acagatgcag attctaggga   7020

ccactccaga cctacagaat cagaaactct tgggggaggg cccgaaatat ctatgtttta   7080

ccaagcccac cacatgattc tgatgtactc taaatactga gaaaacctgt tctatcaatc   7140

caagcacact ccgcaggcag ttaccagtac ggctggctac aactgctcca tccgtgcctc   7200

tttttaaagt tcaaactcac aggtgactct aaggttatct acttttactc ataagtaaaa   7260

gccctagact ggtgctaatg tcaaaccact ggcctccact caggcctcca tcttctcatg   7320

ccctcttacc agtatttaac ttctgaggaa gacaagtgat gctaaaacct gaattccaat   7380

gaagccatat gaaccagctg tcagttgcac ttctaagact ttacttagca gtaaattata   7440

gctcatgtgc attatttcag atacttagct tatgagtagc ttatacaatt agtgaagatt   7500

aatattacag attaaatgta actgttctta aattgggctc acttgattca cagcgtgcat   7560

acacagattg tgagaagtct tcagcaagat aaacattatt aactaactta tttatgaagt   7620

attaaaatgc ttacatttga acttgatggc taacttacta agattctcta tgtatcaaat   7680

gtaacttact gcgactaaac ttaatttaat atttactcta taaccaaatg aaatatattt   7740

aaaatatatt gaatatttta tattgttata tcctgacaag attgttaata ttttaatgta   7800

ctaatatttc tgtcaattat atctaaatat tattttatta tattgcctaa gaataaacat   7860

ttgttaaatt gg                                                       7872


<210>  1518
<211>  1498
<212>  PRT
<213>  Homosapiens

<400>  1518

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Asp 
    1475                 1480                 1485             


Ala Leu  Phe Val Lys Val Leu  Arg Ser Pro 
    1490                 1495             


<210>  1519
<211>  7584
<212>  DNA
<213>  Homosapiens

<400>  1519
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg     60

agctttccag ccgggctccc agagcgcgct gcgcaggaga cgcggtggcc tgagagcctg    120

agggtccccg gactcgccca ggctctgagc tctctcccac catgagcgcc cggaccgccc    180

ccaggccgca ggtgctcctg ctgccgctcc tgctggtgct cctggcggcg gcgcccgcag    240

ccagcaaggg ttgtgtctgt aaagacaaag gccagtgctt ctgtgacggg gccaaagggg    300

agaaggggga gaagggcttt cctggacccc ccggttctcc tggccagaaa ggattcacag    360

gtcctgaagg cttgcctgga ccgcagggac ccaagggctt tccaggactt ccaggactca    420

cgggttccaa aggtgtaagg ggaataagtg gattgccagg attttctggt tctcctggac    480

ttccaggcac cccaggcaat accgggcctt acggacttgt cggtgtacca ggatgcagtg    540

gttctaaggg tgagcagggg tttccaggac tcccagggac accgggctac ccagggatcc    600

cgggtgctgc tggtttgaaa ggacaaaagg gtgctcctgc taaaggagaa gatatagaac    660

ttgatgcaaa aggcgacccc gggttgccag gggctccagg accccagggt ttgccaggcc    720

ctccaggttt tcctgggcct gttggcccac ctggtcctcc gggattcttt ggctttccag    780

gagccatggg acctagagga cctaagggtc acatgggtga aagagtgata ggacataaag    840

gagagcgggg tgtgaaaggg ttaacaggac ccccgggacc accaggaaca gttattgtga    900

ccctaactgg cccagataac agaacggacc tcaaggggga aaagggagac aagggagcaa    960

tgggcgagcc tggacctcct ggaccctcag gactgcctgg agaatcatat ggatctgaaa   1020

agggtgctcc tggagaccct ggcctgcagg gaaaacccgg aaaagatggt gttcctggct   1080

tccctggaag tgagggagtc aagggcaaca ggggtttccc tgggttaatg ggtgaagatg   1140

gcattaaggg acagaaaggg gacattggcc ctccaggatt tcgtggtcca acagaatatt   1200

atgacacata ccaggaaaag ggagatgaag gcactccagg cccaccaggg cccagaggag   1260

ctcgtggccc acaaggtccc agtggtcccc ccggagttcc tggaagtcct ggatcatcaa   1320

ggcctggcct cagaggagcc cctggatggc caggcttgaa aggaagtaaa ggggaacgag   1380

gccgcccagg aaaggatgcc atggggactc ctgggtcccc aggttgtgct ggttcaccag   1440

gtcttccagg atcaccggga cctccaggac cgccaggtga catcgttttt cgcaagggtc   1500

cacctggaga tcacggactg ccaggctatc tagggtctcc aggaatccca ggagttgatg   1560

ggcccaaagg agaaccaggc ctcctgtgta cacagtgccc ttatatccca gggcctcccg   1620

gtctcccagg attgccaggg ttacatggtg taaaaggaat cccaggaaga caaggcgcag   1680

ctggcttgaa aggaagccca gggtccccag gaaatacagg tcttccagga tttccaggtt   1740

tcccaggtgc ccagggtgac ccaggactta aaggagaaaa aggtgaaaca cttcagcctg   1800

aggggcaagt gggtgtccca ggtgacccgg ggctcagagg ccaacctggg agaaagggct   1860

tggatggaat tcctggaact ctgggagtga aaggattacc aggacctaaa ggcgaactgg   1920

ctctgagtgg tgagaaaggg gaccaaggtc ctccagggga tcctggctcc cctgggtccc   1980

caggacctgc aggaccagct ggaccacctg gctacggacc ccaaggagaa cctggtctcc   2040

agggcacgca aggagttcct ggggcccccg gaccacccgg agaagccggc cctaggggag   2100

agctcagtgt ttcaacacca gttccaggcc ctccaggacc tccagggccc cctggccatc   2160

ctggccccca aggtccacct ggtatccctg gatccctggg gaaatgtgga gatcctggtc   2220

ttccagggcc tgatggtgaa ccaggaattc caggaattgg atttcctggg ccacctggac   2280

ctaagggaga ccaaggtttt ccaggtacaa aaggatcact gggttgtcct ggaaaaatgg   2340

gagagcctgg gttacctgga aagccaggcc tcccaggagc caagggagaa ccagcagtag   2400

ccatgcctgg aggaccagga acaccaggtt ttccaggaga aagaggcaat tctggggaac   2460

atggagaaat tggactccct ggacttccag gtctccctgg aactccagga aatgaagggc   2520

ttgatggacc acgaggagat ccagggcagc ctggaccacc tggagaacaa ggacccccag   2580

gaaggtgcat agagggtccc aggggagccc aaggacttcc aggcttaaat ggattgaaag   2640

ggcaacaagg cagaagaggt aaaacggggc caaagggaga cccaggaatt ccaggcttgg   2700

atagatcagg atttcctgga gaaactggat caccaggaat tccaggtcat caaggtgaaa   2760

tgggaccact gggtcaaaga ggatatccag gaaatccggg aattttaggg ccaccaggtg   2820

aagatggagt gattgggatg atgggatttc ctggagccat tggccctcca gggccccctg   2880

ggaacccagg cacaccaggg cagaggggga gccctggaat tccaggagta aagggccaga   2940

gaggaacccc aggagccaag ggggaacaag gagataaagg aaatcccggg ccttcagaga   3000

tatcccacgt aataggggac aaaggagaac caggtctcaa aggattcgca ggaaatccag   3060

gtgagaaagg aaacagaggc gttccaggga tgccaggttt aaagggcctc aaaggactac   3120

ccggaccagc aggaccacca ggccccagag gagatttggg cagcactggg aatcctggag   3180

aaccaggact ccgtggtata ccaggaagca tggggaacat gggcatgcca ggttctaaag   3240

gaaaaagggg aactttggga ttcccaggtc gagcaggaag accaggcctc ccaggtattc   3300

atggtctcca gggagataag ggagagccag gttattcaga aggtacaagg ccaggaccac   3360

cgggaccaac gggggatcca ggactgccgg gtgatatggg aaagaaagga gaaatggggc   3420

aacctggccc acctggacat ttggggcctg ctggacctga gggagcccct ggaagtcctg   3480

gaagtcctgg cctcccagga aagccaggtc ctcatggtga tttgggtttt aaaggaatca   3540

aaggcctcct gggccctcca ggaatcagag gccctccagg tcttccagga tttccaggat   3600

ctcctggacc aatgggtata agaggtgacc aaggacgtga tggaattcct ggtccagccg   3660

gagaaaaggg agaaacgggt ttattgaggg cccctccagg cccaagaggg aaccctggtg   3720

ctcaaggagc caaaggagac aggggagccc caggttttcc tggcctcccg ggcagaaaag   3780

gggccatggg agatgctgga cctcgaggac ccacaggcat agaaggattc ccagggccac   3840

caggtctgcc cggtgcaatt atccctggcc agacaggaaa tcgtggtcca ccaggctcaa   3900

gaggaagccc aggtgcgcct ggtccccctg gacctccagg gagtcatgta ataggcataa   3960

aaggagacaa agggtctatg ggccaccctg gcccaaaagg tccacctgga actgcaggag   4020

acatgggacc accaggtcgt ctgggagcac caggtactcc aggtcttcca ggacccagag   4080

gtgatcctgg attccagggg tttccaggcg tgaaaggaga aaagggtaat cctggatttc   4140

taggatccat tggacctcca ggaccaattg ggccaaaagg accacctggt gtacgtggag   4200

accctggcac acttaagatt atctcccttc caggaagccc agggccacct ggcacacctg   4260

gagaaccagg gatgcaggga gaacctgggc caccagggcc acctggaaac ctaggaccct   4320

gtgggccaag aggtaagcca ggcaaggatg gaaaaccagg aactcctgga ccagctggag   4380

aaaaaggcaa caaaggttct aaaggagagc caggaccagc tggatcagat ggattgccag   4440

gtttgaaagg aaaacgtgga gacagtggat cacctgcaac ctggacaacg agaggctttg   4500

tcttcacccg acacagtcaa accacagcaa ttccttcatg tccagagggg acagtgccac   4560

tctacagtgg gttttctttt ctttttgtac aaggaaatca acgagcccac ggacaagacc   4620

ttgaaagcct attccatcaa ctgtgaaagc tggggaatta gaaaaaataa taagtcgctg   4680

tcaggtgtgc atgaagaaaa gacactgaag ctaaaaaaga catgcagaac tgctattttt   4740

catcctaaag aacaaagtaa tgacagaaca tgctgttatt taggtatttt tctttaacca   4800

aacaatattg ctccatgatg acttagtaca aagtttcaat ttgtttcccc acaaaacaaa   4860

gcaattcttt caagtgcagt tctgtgatct gggtctctaa tctgtgctgt ttcaaagttc   4920

tctgtggcaa agcagcaact attcacaaaa tatcaccaaa aacctattcc acttacatcc   4980

aaggcactgt cactacggtg attgtatgaa gtttgaatgc tgcacgttat gaaatatttg   5040

gcccgctgga ttcccacatt tgtcttcttt ctgtctttaa gactcaggga ggctaaatca   5100

gtgtttgatt gccccgccaa cccttcctga aacttcagac cctgggtagg gaagagaagg   5160

ggcatgtggt atctggagca ttgtgtatag aactggattt tcagacctgc tgaggaccgt   5220

aaggcctgat ggaacacaga actgaactga ggttcatgga ttttccagga ctgtttcaaa   5280

catgcccatt actaacggca aaagggggat tccctgatgg aaccataata cccttggaaa   5340

tactgtatgg ttttgttttg ttttgttggt ttttaaagat ttttgtttgt ttattgaatt   5400

cattcactgt agctctaaaa tctgcttgta tccaagcata taaaattttc ccccttagtg   5460

aattagtttt aaaatgatat tgttatatac atactatgaa atatgtataa ctttaacttc   5520

tgttttacca gcatacgcac acaaataaca agaatactac ttatgaaatg tgcactttat   5580

cctcattcca taaatgttgg tgcatacctt atgtaaggga gcagttcaat aatccatgaa   5640

agaacttaag gcatttgttg gtttatcaga ctcggaatct atttttctca ttgctctgaa   5700

tatgtcatca ctctaggttt tacagattta ttcctttgtt acttctctaa ttcttccttt   5760

gtaaaaaaaa aaaaagcaac actttttttt atgttatatg ttgtcttaca aaccatactg   5820

aaagagtcat tgtttaaaat cttaatgtat caaactgtat aacttggccg ctgtatgtct   5880

taaaacctgc ttttcaatgt gttgatacat tcccaaggtt acttaattca acttaactat   5940

catgttattc agcaccaagc atgtccaggc actgtactaa cctacagaga tgctaagaga   6000

aaaaaaagac ttgtttctga tctaatatcc agaaaaagta actcattgct ctgtaataat   6060

ctcacatata cagtagcttc ctccctctag ttttttcttc cttgtcactg ctgttatatt   6120

tcatcatgat aattcagcag gccagtaagg taaaaataag gtctatgcct agggaaactc   6180

aggcttctag tttctcttag aaaagctaag agaagataag gtctgaataa tagcagaaaa   6240

accaacatct acaaaacatt aaactagtgt tataccttga tgataacact attgatgagt   6300

cttagagtcc agacacaaag agacaaagct ttgaagatgc ttttgatcta cctaggtgga   6360

gttggtggtg ctgatattta aattcaggct actgcttcaa tctcaattgc tttgtaagtg   6420

aaaacatgac ccagagacag acagactatg gccatggctc acatggttta catccttcac   6480

tgctcacgtg tttgctgtca agccattttt acagtctgaa actaagatgt gcagcatttc   6540

acttatttag attcacttaa caaacaaatt tttctgcttt aaaaatgtct tattgtccca   6600

aggtactata gcggatatag agctagctaa tctctacaaa ccctctgtag gccagtagtt   6660

ctcaaagtgt ggtctctgga agagcagtat cagcatcatc tgggaacttg tcacagatgc   6720

agattctagg gaccactcca gacctacaga atcagaaact cttgggggag ggcccgaaat   6780

atctatgttt taccaagccc accacatgat tctgatgtac tctaaatact gagaaaacct   6840

gttctatcaa tccaagcaca ctccgcaggc agttaccagt acggctggct acaactgctc   6900

catccgtgcc tctttttaaa gttcaaactc acaggtgact ctaaggttat ctacttttac   6960

tcataagtaa aagccctaga ctggtgctaa tgtcaaacca ctggcctcca ctcaggcctc   7020

catcttctca tgccctctta ccagtattta acttctgagg aagacaagtg atgctaaaac   7080

ctgaattcca atgaagccat atgaaccagc tgtcagttgc acttctaaga ctttacttag   7140

cagtaaatta tagctcatgt gcattatttc agatacttag cttatgagta gcttatacaa   7200

ttagtgaaga ttaatattac agattaaatg taactgttct taaattgggc tcacttgatt   7260

cacagcgtgc atacacagat tgtgagaagt cttcagcaag ataaacatta ttaactaact   7320

tatttatgaa gtattaaaat gcttacattt gaacttgatg gctaacttac taagattctc   7380

tatgtatcaa atgtaactta ctgcgactaa acttaattta atatttactc tataaccaaa   7440

tgaaatatat ttaaaatata ttgaatattt tatattgtta tatcctgaca agattgttaa   7500

tattttaatg tactaatatt tctgtcaatt atatctaaat attattttat tatattgcct   7560

aagaataaac atttgttaaa ttgg                                          7584


<210>  1520
<211>  1494
<212>  PRT
<213>  Homosapiens

<400>  1520

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Glu 
    1475                 1480                 1485             


Ser Leu  Phe His Gln Leu 
    1490                 


<210>  1521
<211>  7374
<212>  DNA
<213>  Homosapiens

<400>  1521
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg     60

agctttccag ccgggctccc agagcgcgct gcgcaggaga cgcggtggcc tgagagcctg    120

agggtccccg gactcgccca ggctctgagc tctctcccac catgagcgcc cggaccgccc    180

ccaggccgca ggtgctcctg ctgccgctcc tgctggtgct cctggcggcg gcgcccgcag    240

ccagcaaggg ttgtgtctgt aaagacaaag gccagtgctt ctgtgacggg gccaaagggg    300

agaaggggga gaagggcttt cctggacccc ccggttctcc tggccagaaa ggattcacag    360

gtcctgaagg cttgcctgga ccgcagggac ccaagggctt tccaggactt ccaggactca    420

cgggttccaa aggtgtaagg ggaataagtg gattgccagg attttctggt tctcctggac    480

ttccaggcac cccaggcaat accgggcctt acggacttgt cggtgtacca ggatgcagtg    540

gttctaaggg tgagcagggg tttccaggac tcccagggac accgggctac ccagggatcc    600

cgggtgctgc tggtttgaaa ggacaaaagg gtgctcctgc taaaggagaa gatatagaac    660

ttgatgcaaa aggcgacccc gggttgccag gggctccagg accccagggt ttgccaggcc    720

ctccaggttt tcctgggcct gttggcccac ctggtcctcc gggattcttt ggctttccag    780

gagccatggg acctagagga cctaagggtc acatgggtga aagagtgata ggacataaag    840

gagagcgggg tgtgaaaggg ttaacaggac ccccgggacc accaggaaca gttattgtga    900

ccctaactgg cccagataac agaacggacc tcaaggggga aaagggagac aagggagcaa    960

tgggcgagcc tggacctcct ggaccctcag gactgcctgg agaatcatat ggatctgaaa   1020

agggtgctcc tggagaccct ggcctgcagg gaaaacccgg aaaagatggt gttcctggct   1080

tccctggaag tgagggagtc aagggcaaca ggggtttccc tgggttaatg ggtgaagatg   1140

gcattaaggg acagaaaggg gacattggcc ctccaggatt tcgtggtcca acagaatatt   1200

atgacacata ccaggaaaag ggagatgaag gcactccagg cccaccaggg cccagaggag   1260

ctcgtggccc acaaggtccc agtggtcccc ccggagttcc tggaagtcct ggatcatcaa   1320

ggcctggcct cagaggagcc cctggatggc caggcttgaa aggaagtaaa ggggaacgag   1380

gccgcccagg aaaggatgcc atggggactc ctgggtcccc aggttgtgct ggttcaccag   1440

gtcttccagg atcaccggga cctccaggac cgccaggtga catcgttttt cgcaagggtc   1500

cacctggaga tcacggactg ccaggctatc tagggtctcc aggaatccca ggagttgatg   1560

ggcccaaagg agaaccaggc ctcctgtgta cacagtgccc ttatatccca gggcctcccg   1620

gtctcccagg attgccaggg ttacatggtg taaaaggaat cccaggaaga caaggcgcag   1680

ctggcttgaa aggaagccca gggtccccag gaaatacagg tcttccagga tttccaggtt   1740

tcccaggtgc ccagggtgac ccaggactta aaggagaaaa aggtgaaaca cttcagcctg   1800

aggggcaagt gggtgtccca ggtgacccgg ggctcagagg ccaacctggg agaaagggct   1860

tggatggaat tcctggaact ctgggagtga aaggattacc aggacctaaa ggcgaactgg   1920

ctctgagtgg tgagaaaggg gaccaaggtc ctccagggga tcctggctcc cctgggtccc   1980

caggacctgc aggaccagct ggaccacctg gctacggacc ccaaggagaa cctggtctcc   2040

agggcacgca aggagttcct ggggcccccg gaccacccgg agaagccggc cctaggggag   2100

agctcagtgt ttcaacacca gttccaggcc ctccaggacc tccagggccc cctggccatc   2160

ctggccccca aggtccacct ggtatccctg gatccctggg gaaatgtgga gatcctggtc   2220

ttccagggcc tgatggtgaa ccaggaattc caggaattgg atttcctggg ccacctggac   2280

ctaagggaga ccaaggtttt ccaggtacaa aaggatcact gggttgtcct ggaaaaatgg   2340

gagagcctgg gttacctgga aagccaggcc tcccaggagc caagggagaa ccagcagtag   2400

ccatgcctgg aggaccagga acaccaggtt ttccaggaga aagaggcaat tctggggaac   2460

atggagaaat tggactccct ggacttccag gtctccctgg aactccagga aatgaagggc   2520

ttgatggacc acgaggagat ccagggcagc ctggaccacc tggagaacaa ggacccccag   2580

gaaggtgcat agagggtccc aggggagccc aaggacttcc aggcttaaat ggattgaaag   2640

ggcaacaagg cagaagaggt aaaacggggc caaagggaga cccaggaatt ccaggcttgg   2700

atagatcagg atttcctgga gaaactggat caccaggaat tccaggtcat caaggtgaaa   2760

tgggaccact gggtcaaaga ggatatccag gaaatccggg aattttaggg ccaccaggtg   2820

aagatggagt gattgggatg atgggatttc ctggagccat tggccctcca gggccccctg   2880

ggaacccagg cacaccaggg cagaggggga gccctggaat tccaggagta aagggccaga   2940

gaggaacccc aggagccaag ggggaacaag gagataaagg aaatcccggg ccttcagaga   3000

tatcccacgt aataggggac aaaggagaac caggtctcaa aggattcgca ggaaatccag   3060

gtgagaaagg aaacagaggc gttccaggga tgccaggttt aaagggcctc aaaggactac   3120

ccggaccagc aggaccacca ggccccagag gagatttggg cagcactggg aatcctggag   3180

aaccaggact ccgtggtata ccaggaagca tggggaacat gggcatgcca ggttctaaag   3240

gaaaaagggg aactttggga ttcccaggtc gagcaggaag accaggcctc ccaggtattc   3300

atggtctcca gggagataag ggagagccag gttattcaga aggtacaagg ccaggaccac   3360

cgggaccaac gggggatcca ggactgccgg gtgatatggg aaagaaagga gaaatggggc   3420

aacctggccc acctggacat ttggggcctg ctggacctga gggagcccct ggaagtcctg   3480

gaagtcctgg cctcccagga aagccaggtc ctcatggtga tttgggtttt aaaggaatca   3540

aaggcctcct gggccctcca ggaatcagag gccctccagg tcttccagga tttccaggat   3600

ctcctggacc aatgggtata agaggtgacc aaggacgtga tggaattcct ggtccagccg   3660

gagaaaaggg agaaacgggt ttattgaggg cccctccagg cccaagaggg aaccctggtg   3720

ctcaaggagc caaaggagac aggggagccc caggttttcc tggcctcccg ggcagaaaag   3780

gggccatggg agatgctgga cctcgaggac ccacaggcat agaaggattc ccagggccac   3840

caggtctgcc cggtgcaatt atccctggcc agacaggaaa tcgtggtcca ccaggctcaa   3900

gaggaagccc aggtgcgcct ggtccccctg gacctccagg gagtcatgta ataggcataa   3960

aaggagacaa agggtctatg ggccaccctg gcccaaaagg tccacctgga actgcaggag   4020

acatgggacc accaggtcgt ctgggagcac caggtactcc aggtcttcca ggacccagag   4080

gtgatcctgg attccagggg tttccaggcg tgaaaggaga aaagggtaat cctggatttc   4140

taggatccat tggacctcca ggaccaattg ggccaaaagg accacctggt gtacgtggag   4200

accctggcac acttaagatt atctcccttc caggaagccc agggccacct ggcacacctg   4260

gagaaccagg gatgcaggga gaacctgggc caccagggcc acctggaaac ctaggaccct   4320

gtgggccaag aggtaagcca ggcaaggatg gaaaaccagg aactcctgga ccagctggag   4380

aaaaaggcaa caaaggttct aaaggagagc cagaaagcct attccatcaa ctgtgaaagc   4440

tggggaatta gaaaaaataa taagtcgctg tcaggtgtgc atgaagaaaa gacactgaag   4500

ctaaaaaaga catgcagaac tgctattttt catcctaaag aacaaagtaa tgacagaaca   4560

tgctgttatt taggtatttt tctttaacca aacaatattg ctccatgatg acttagtaca   4620

aagtttcaat ttgtttcccc acaaaacaaa gcaattcttt caagtgcagt tctgtgatct   4680

gggtctctaa tctgtgctgt ttcaaagttc tctgtggcaa agcagcaact attcacaaaa   4740

tatcaccaaa aacctattcc acttacatcc aaggcactgt cactacggtg attgtatgaa   4800

gtttgaatgc tgcacgttat gaaatatttg gcccgctgga ttcccacatt tgtcttcttt   4860

ctgtctttaa gactcaggga ggctaaatca gtgtttgatt gccccgccaa cccttcctga   4920

aacttcagac cctgggtagg gaagagaagg ggcatgtggt atctggagca ttgtgtatag   4980

aactggattt tcagacctgc tgaggaccgt aaggcctgat ggaacacaga actgaactga   5040

ggttcatgga ttttccagga ctgtttcaaa catgcccatt actaacggca aaagggggat   5100

tccctgatgg aaccataata cccttggaaa tactgtatgg ttttgttttg ttttgttggt   5160

ttttaaagat ttttgtttgt ttattgaatt cattcactgt agctctaaaa tctgcttgta   5220

tccaagcata taaaattttc ccccttagtg aattagtttt aaaatgatat tgttatatac   5280

atactatgaa atatgtataa ctttaacttc tgttttacca gcatacgcac acaaataaca   5340

agaatactac ttatgaaatg tgcactttat cctcattcca taaatgttgg tgcatacctt   5400

atgtaaggga gcagttcaat aatccatgaa agaacttaag gcatttgttg gtttatcaga   5460

ctcggaatct atttttctca ttgctctgaa tatgtcatca ctctaggttt tacagattta   5520

ttcctttgtt acttctctaa ttcttccttt gtaaaaaaaa aaaaagcaac actttttttt   5580

atgttatatg ttgtcttaca aaccatactg aaagagtcat tgtttaaaat cttaatgtat   5640

caaactgtat aacttggccg ctgtatgtct taaaacctgc ttttcaatgt gttgatacat   5700

tcccaaggtt acttaattca acttaactat catgttattc agcaccaagc atgtccaggc   5760

actgtactaa cctacagaga tgctaagaga aaaaaaagac ttgtttctga tctaatatcc   5820

agaaaaagta actcattgct ctgtaataat ctcacatata cagtagcttc ctccctctag   5880

ttttttcttc cttgtcactg ctgttatatt tcatcatgat aattcagcag gccagtaagg   5940

taaaaataag gtctatgcct agggaaactc aggcttctag tttctcttag aaaagctaag   6000

agaagataag gtctgaataa tagcagaaaa accaacatct acaaaacatt aaactagtgt   6060

tataccttga tgataacact attgatgagt cttagagtcc agacacaaag agacaaagct   6120

ttgaagatgc ttttgatcta cctaggtgga gttggtggtg ctgatattta aattcaggct   6180

actgcttcaa tctcaattgc tttgtaagtg aaaacatgac ccagagacag acagactatg   6240

gccatggctc acatggttta catccttcac tgctcacgtg tttgctgtca agccattttt   6300

acagtctgaa actaagatgt gcagcatttc acttatttag attcacttaa caaacaaatt   6360

tttctgcttt aaaaatgtct tattgtccca aggtactata gcggatatag agctagctaa   6420

tctctacaaa ccctctgtag gccagtagtt ctcaaagtgt ggtctctgga agagcagtat   6480

cagcatcatc tgggaacttg tcacagatgc agattctagg gaccactcca gacctacaga   6540

atcagaaact cttgggggag ggcccgaaat atctatgttt taccaagccc accacatgat   6600

tctgatgtac tctaaatact gagaaaacct gttctatcaa tccaagcaca ctccgcaggc   6660

agttaccagt acggctggct acaactgctc catccgtgcc tctttttaaa gttcaaactc   6720

acaggtgact ctaaggttat ctacttttac tcataagtaa aagccctaga ctggtgctaa   6780

tgtcaaacca ctggcctcca ctcaggcctc catcttctca tgccctctta ccagtattta   6840

acttctgagg aagacaagtg atgctaaaac ctgaattcca atgaagccat atgaaccagc   6900

tgtcagttgc acttctaaga ctttacttag cagtaaatta tagctcatgt gcattatttc   6960

agatacttag cttatgagta gcttatacaa ttagtgaaga ttaatattac agattaaatg   7020

taactgttct taaattgggc tcacttgatt cacagcgtgc atacacagat tgtgagaagt   7080

cttcagcaag ataaacatta ttaactaact tatttatgaa gtattaaaat gcttacattt   7140

gaacttgatg gctaacttac taagattctc tatgtatcaa atgtaactta ctgcgactaa   7200

acttaattta atatttactc tataaccaaa tgaaatatat ttaaaatata ttgaatattt   7260

tatattgtta tatcctgaca agattgttaa tattttaatg tactaatatt tctgtcaatt   7320

atatctaaat attattttat tatattgcct aagaataaac atttgttaaa ttgg         7374


<210>  1522
<211>  1424
<212>  PRT
<213>  Homosapiens

<400>  1522

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Glu Ser Leu  Phe His Gln Leu 
    1415                 1420                 


<210>  1523
<211>  7877
<212>  DNA
<213>  Homosapiens

<400>  1523
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg     60

agctttccag ccgggctccc agagcgcgct gcgcaggaga cgcggtggcc tgagagcctg    120

agggtccccg gactcgccca ggctctgagc tctctcccac catgagcgcc cggaccgccc    180

ccaggccgca ggtgctcctg ctgccgctcc tgctggtgct cctggcggcg gcgcccgcag    240

ccagcaaggg ttgtgtctgt aaagacaaag gccagtgctt ctgtgacggg gccaaagggg    300

agaaggggga gaagggcttt cctggacccc ccggttctcc tggccagaaa ggattcacag    360

gtcctgaagg cttgcctgga ccgcagggac ccaagggctt tccaggactt ccaggactca    420

cgggttccaa aggtgtaagg ggaataagtg gattgccagg attttctggt tctcctggac    480

ttccaggcac cccaggcaat accgggcctt acggacttgt cggtgtacca ggatgcagtg    540

gttctaaggg tgagcagggg tttccaggac tcccagggac accgggctac ccagggatcc    600

cgggtgctgc tggtttgaaa ggacaaaagg gtgctcctgc taaaggagaa gatatagaac    660

ttgatgcaaa aggcgacccc gggttgccag gggctccagg accccagggt ttgccaggcc    720

ctccaggttt tcctgggcct gttggcccac ctggtcctcc gggattcttt ggctttccag    780

gagccatggg acctagagga cctaagggtc acatgggtga aagagtgata ggacataaag    840

gagagcgggg tgtgaaaggg ttaacaggac ccccgggacc accaggaaca gttattgtga    900

ccctaactgg cccagataac agaacggacc tcaaggggga aaagggagac aagggagcaa    960

tgggcgagcc tggacctcct ggaccctcag gactgcctgg agaatcatat ggatctgaaa   1020

agggtgctcc tggagaccct ggcctgcagg gaaaacccgg aaaagatggt gttcctggct   1080

tccctggaag tgagggagtc aagggcaaca ggggtttccc tgggttaatg ggtgaagatg   1140

gcattaaggg acagaaaggg gacattggcc ctccaggatt tcgtggtcca acagaatatt   1200

atgacacata ccaggaaaag ggagatgaag gcactccagg cccaccaggg cccagaggag   1260

ctcgtggccc acaaggtccc agtggtcccc ccggagttcc tggaagtcct ggatcatcaa   1320

ggcctggcct cagaggagcc cctggatggc caggcttgaa aggaagtaaa ggggaacgag   1380

gccgcccagg aaaggatgcc atggggactc ctgggtcccc aggttgtgct ggttcaccag   1440

gtcttccagg atcaccggga cctccaggac cgccaggtga catcgttttt cgcaagggtc   1500

cacctggaga tcacggactg ccaggctatc tagggtctcc aggaatccca ggagttgatg   1560

ggcccaaagg agaaccaggc ctcctgtgta cacagtgccc ttatatccca gggcctcccg   1620

gtctcccagg attgccaggg ttacatggtg taaaaggaat cccaggaaga caaggcgcag   1680

ctggcttgaa aggaagccca gggtccccag gaaatacagg tcttccagga tttccaggtt   1740

tcccaggtgc ccagggtgac ccaggactta aaggagaaaa aggtgaaaca cttcagcctg   1800

aggggcaagt gggtgtccca ggtgacccgg ggctcagagg ccaacctggg agaaagggct   1860

tggatggaat tcctggaact ctgggagtga aaggattacc aggacctaaa ggcgaactgg   1920

ctctgagtgg tgagaaaggg gaccaaggtc ctccagggga tcctggctcc cctgggtccc   1980

caggacctgc aggaccagct ggaccacctg gctacggacc ccaaggagaa cctggtctcc   2040

agggcacgca aggagttcct ggggcccccg gaccacccgg agaagccggc cctaggggag   2100

agctcagtgt ttcaacacca gttccaggcc ctccaggacc tccagggccc cctggccatc   2160

ctggccccca aggtccacct ggtatccctg gatccctggg gaaatgtgga gatcctggtc   2220

ttccagggcc tgatggtgaa ccaggaattc caggaattgg atttcctggg ccacctggac   2280

ctaagggaga ccaaggtttt ccaggtacaa aaggatcact gggttgtcct ggaaaaatgg   2340

gagagcctgg gttacctgga aagccaggcc tcccaggagc caagggagaa ccagcagtag   2400

ccatgcctgg aggaccagga acaccaggtt ttccaggaga aagaggcaat tctggggaac   2460

atggagaaat tggactccct ggacttccag gtctccctgg aactccagga aatgaagggc   2520

ttgatggacc acgaggagat ccagggcagc ctggaccacc tggagaacaa ggacccccag   2580

gaaggtgcat agagggtccc aggggagccc aaggacttcc aggcttaaat ggattgaaag   2640

ggcaacaagg cagaagaggt aaaacggggc caaagggaga cccaggaatt ccaggcttgg   2700

atagatcagg atttcctgga gaaactggat caccaggaat tccaggtcat caaggtgaaa   2760

tgggaccact gggtcaaaga ggatatccag gaaatccggg aattttaggg ccaccaggtg   2820

aagatggagt gattgggatg atgggatttc ctggagccat tggccctcca gggccccctg   2880

ggaacccagg cacaccaggg cagaggggga gccctggaat tccaggagta aagggccaga   2940

gaggaacccc aggagccaag ggggaacaag gagataaagg aaatcccggg ccttcagaga   3000

tatcccacgt aataggggac aaaggagaac caggtctcaa aggattcgca ggaaatccag   3060

gtgagaaagg aaacagaggc gttccaggga tgccaggttt aaagggcctc aaaggactac   3120

ccggaccagc aggaccacca ggccccagag gagatttggg cagcactggg aatcctggag   3180

aaccaggact ccgtggtata ccaggaagca tggggaacat gggcatgcca ggttctaaag   3240

gaaaaagggg aactttggga ttcccaggtc gagcaggaag accaggcctc ccaggtattc   3300

atggtctcca gggagataag ggagagccag gttattcaga aggtacaagg ccaggaccac   3360

cgggaccaac gggggatcca ggactgccgg gtgatatggg aaagaaagga gaaatggggc   3420

aacctggccc acctggacat ttggggcctg ctggacctga gggagcccct ggaagtcctg   3480

gaagtcctgg cctcccagga aagccaggtc ctcatggtga tttgggtttt aaaggaatca   3540

aaggcctcct gggccctcca ggaatcagag gccctccagg tcttccagga tttccaggat   3600

ctcctggacc aatgggtata agaggtgacc aaggacgtga tggaattcct ggtccagccg   3660

gagaaaaggg agaaacgggt ttattgaggg cccctccagg cccaagaggg aaccctggtg   3720

ctcaaggagc caaaggagac aggggagccc caggttttcc tggcctcccg ggcagaaaag   3780

gggccatggg agatgctgga cctcgaggac ccacaggcat agaaggattc ccagggccac   3840

caggtctgcc cggtgcaatt atccctggcc agacaggaaa tcgtggtcca ccaggctcaa   3900

gaggaagccc aggtgcgcct ggtccccctg gacctccagg gagtcatgta ataggcataa   3960

aaggagacaa agggtctatg ggccaccctg gcccaaaagg tccacctgga actgcaggag   4020

acatgggacc accaggtcgt ctgggagcac caggtactcc aggtcttcca ggacccagag   4080

gtgatcctgg attccagggg tttccaggcg tgaaaggaga aaagggtaat cctggatttc   4140

taggatccat tggacctcca ggaccaattg ggccaaaagg accacctggt gtacgtggag   4200

accctggcac acttaagatt atctcccttc caggaagccc agggccacct ggcacacctg   4260

gagaaccagg gatgcaggga gaacctgggc caccagggcc acctggaaac ctaggaccct   4320

gtgggccaag aggtaagcca ggcaaggatg gaaaaccagg aactcctgga ccagctggag   4380

aaaaaggcaa caaaggttct aaaggagagc caggaccagc tggatcagat ggattgccag   4440

gtttgaaagg aaaacgtgga gacagtggat cacctgcaac ctggacaacg agaggctttg   4500

tcttcacccg acacagtcaa accacagcaa ttccttcatg tccagagggg acagtgccac   4560

tctacagtgg gttttctttt ctttttgtac aaggaaatca acgagcccac ggacaagacc   4620

ttggaactct tggcagctgc ctgcagcgat ttaccacaat gccattctta ttctgcaatg   4680

tcaatgatgt atgtaatttt gcatctcgaa atgattattc atactggctg tcaacaccag   4740

ctctgatgcc aatgaacatg gctcccatta ctggcatagc ccttgagcct tatataagca   4800

gatgcactgt ttgtgaaggt cctgcgatcg ccatagccgt tcacagccaa accactgaca   4860

ttcctccatg tcctcacggc tggatttctc tctggaaagg attttcattc atcatgaaag   4920

cctattccat caactgtgaa agctggggaa ttagaaaaaa taataagtcg ctgtcaggtg   4980

tgcatgaaga aaagacactg aagctaaaaa agacatgcag aactgctatt tttcatccta   5040

aagaacaaag taatgacaga acatgctgtt atttaggtat ttttctttaa ccaaacaata   5100

ttgctccatg atgacttagt acaaagtttc aatttgtttc cccacaaaac aaagcaattc   5160

tttcaagtgc agttctgtga tctgggtctc taatctgtgc tgtttcaaag ttctctgtgg   5220

caaagcagca actattcaca aaatatcacc aaaaacctat tccacttaca tccaaggcac   5280

tgtcactacg gtgattgtat gaagtttgaa tgctgcacgt tatgaaatat ttggcccgct   5340

ggattcccac atttgtcttc tttctgtctt taagactcag ggaggctaaa tcagtgtttg   5400

attgccccgc caacccttcc tgaaacttca gaccctgggt agggaagaga aggggcatgt   5460

ggtatctgga gcattgtgta tagaactgga ttttcagacc tgctgaggac cgtaaggcct   5520

gatggaacac agaactgaac tgaggttcat ggattttcca ggactgtttc aaacatgccc   5580

attactaacg gcaaaagggg gattccctga tggaaccata atacccttgg aaatactgta   5640

tggttttgtt ttgttttgtt ggtttttaaa gatttttgtt tgtttattga attcattcac   5700

tgtagctcta aaatctgctt gtatccaagc atataaaatt ttccccctta gtgaattagt   5760

tttaaaatga tattgttata tacatactat gaaatatgta taactttaac ttctgtttta   5820

ccagcatacg cacacaaata acaagaatac tacttatgaa atgtgcactt tatcctcatt   5880

ccataaatgt tggtgcatac cttatgtaag ggagcagttc aataatccat gaaagaactt   5940

aaggcatttg ttggtttatc agactcggaa tctatttttc tcattgctct gaatatgtca   6000

tcactctagg ttttacagat ttattccttt gttacttctc taattcttcc tttgtaaaaa   6060

aaaaaaaagc aacacttttt tttatgttat atgttgtctt acaaaccata ctgaaagagt   6120

cattgtttaa aatcttaatg tatcaaactg tataacttgg ccgctgtatg tcttaaaacc   6180

tgcttttcaa tgtgttgata cattcccaag gttacttaat tcaacttaac tatcatgtta   6240

ttcagcacca agcatgtcca ggcactgtac taacctacag agatgctaag agaaaaaaaa   6300

gacttgtttc tgatctaata tccagaaaaa gtaactcatt gctctgtaat aatctcacat   6360

atacagtagc ttcctccctc tagttttttc ttccttgtca ctgctgttat atttcatcat   6420

gataattcag caggccagta aggtaaaaat aaggtctatg cctagggaaa ctcaggcttc   6480

tagtttctct tagaaaagct aagagaagat aaggtctgaa taatagcaga aaaaccaaca   6540

tctacaaaac attaaactag tgttatacct tgatgataac actattgatg agtcttagag   6600

tccagacaca aagagacaaa gctttgaaga tgcttttgat ctacctaggt ggagttggtg   6660

gtgctgatat ttaaattcag gctactgctt caatctcaat tgctttgtaa gtgaaaacat   6720

gacccagaga cagacagact atggccatgg ctcacatggt ttacatcctt cactgctcac   6780

gtgtttgctg tcaagccatt tttacagtct gaaactaaga tgtgcagcat ttcacttatt   6840

tagattcact taacaaacaa atttttctgc tttaaaaatg tcttattgtc ccaaggtact   6900

atagcggata tagagctagc taatctctac aaaccctctg taggccagta gttctcaaag   6960

tgtggtctct ggaagagcag tatcagcatc atctgggaac ttgtcacaga tgcagattct   7020

agggaccact ccagacctac agaatcagaa actcttgggg gagggcccga aatatctatg   7080

ttttaccaag cccaccacat gattctgatg tactctaaat actgagaaaa cctgttctat   7140

caatccaagc acactccgca ggcagttacc agtacggctg gctacaactg ctccatccgt   7200

gcctcttttt aaagttcaaa ctcacaggtg actctaaggt tatctacttt tactcataag   7260

taaaagccct agactggtgc taatgtcaaa ccactggcct ccactcaggc ctccatcttc   7320

tcatgccctc ttaccagtat ttaacttctg aggaagacaa gtgatgctaa aacctgaatt   7380

ccaatgaagc catatgaacc agctgtcagt tgcacttcta agactttact tagcagtaaa   7440

ttatagctca tgtgcattat ttcagatact tagcttatga gtagcttata caattagtga   7500

agattaatat tacagattaa atgtaactgt tcttaaattg ggctcacttg attcacagcg   7560

tgcatacaca gattgtgaga agtcttcagc aagataaaca ttattaacta acttatttat   7620

gaagtattaa aatgcttaca tttgaacttg atggctaact tactaagatt ctctatgtat   7680

caaatgtaac ttactgcgac taaacttaat ttaatattta ctctataacc aaatgaaata   7740

tatttaaaat atattgaata ttttatattg ttatatcctg acaagattgt taatatttta   7800

atgtactaat atttctgtca attatatcta aatattattt tattatattg cctaagaata   7860

aacatttgtt aaattgg                                                  7877


<210>  1524
<211>  1642
<212>  PRT
<213>  Homosapiens

<400>  1524

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Ile Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Lys Ala Tyr Ser Ile  Asn Cys Glu 
    1580                 1585                 1590             


Ser Trp  Gly Ile Arg Lys Asn  Asn Lys Ser Leu Ser  Gly Val His 
    1595                 1600                 1605             


Glu Glu  Lys Thr Leu Lys Leu  Lys Lys Thr Cys Arg  Thr Ala Ile 
    1610                 1615                 1620             


Phe His  Pro Lys Glu Gln Ser  Asn Asp Arg Thr Cys  Cys Tyr Leu 
    1625                 1630                 1635             


Gly Ile  Phe Leu 
    1640         


<210>  1525
<211>  7699
<212>  DNA
<213>  Homosapiens

<400>  1525
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg     60

agctttccag ccgggctccc agagcgcgct gcgcaggaga cgcggtggcc tgagagcctg    120

agggtccccg gactcgccca ggctctgagc tctctcccac catgagcgcc cggaccgccc    180

ccaggccgca ggtgctcctg ctgccgctcc tgctggtgct cctggcggcg gcgcccgcag    240

ccagcaaggg ttgtgtctgt aaagacaaag gccagtgctt ctgtgacggg gccaaagggg    300

agaaggggga gaagggcttt cctggacccc ccggttctcc tggccagaaa ggattcacag    360

gtcctgaagg cttgcctgga ccgcagggac ccaagggctt tccaggactt ccaggactca    420

cgggttccaa aggtgtaagg ggaataagtg gattgccagg attttctggt tctcctggac    480

ttccaggcac cccaggcaat accgggcctt acggacttgt cggtgtacca ggatgcagtg    540

gttctaaggg tgagcagggg tttccaggac tcccagggac accgggctac ccagggatcc    600

cgggtgctgc tggtttgaaa ggacaaaagg gtgctcctgc taaaggagaa gatatagaac    660

ttgatgcaaa aggcgacccc gggttgccag gggctccagg accccagggt ttgccaggcc    720

ctccaggttt tcctgggcct gttggcccac ctggtcctcc gggattcttt ggctttccag    780

gagccatggg acctagagga cctaagggtc acatgggtga aagagtgata ggacataaag    840

gagagcgggg tgtgaaaggg ttaacaggac ccccgggacc accaggaaca gttattgtga    900

ccctaactgg cccagataac agaacggacc tcaaggggga aaagggagac aagggagcaa    960

tgggcgagcc tggacctcct ggaccctcag gactgcctgg agaatcatat ggatctgaaa   1020

agggtgctcc tggagaccct ggcctgcagg gaaaacccgg aaaagatggt gttcctggct   1080

tccctggaag tgagggagtc aagggcaaca ggggtttccc tgggttaatg ggtgaagatg   1140

gcattaaggg acagaaaggg gacattggcc ctccaggatt tcgtggtcca acagaatatt   1200

atgacacata ccaggaaaag ggagatgaag gcactccagg cccaccaggg cccagaggag   1260

ctcgtggccc acaaggtccc agtggtcccc ccggagttcc tggaagtcct ggatcatcaa   1320

ggcctggcct cagaggagcc cctggatggc caggcttgaa aggaagtaaa ggggaacgag   1380

gccgcccagg aaaggatgcc atggggactc ctgggtcccc aggttgtgct ggttcaccag   1440

gtcttccagg atcaccggga cctccaggac cgccaggtga catcgttttt cgcaagggtc   1500

cacctggaga tcacggactg ccaggctatc tagggtctcc aggaatccca ggagttgatg   1560

ggcccaaagg agaaccaggc ctcctgtgta cacagtgccc ttatatccca gggcctcccg   1620

gtctcccagg attgccaggg ttacatggtg taaaaggaat cccaggaaga caaggcgcag   1680

ctggcttgaa aggaagccca gggtccccag gaaatacagg tcttccagga tttccaggtt   1740

tcccaggtgc ccagggtgac ccaggactta aaggagaaaa aggtgaaaca cttcagcctg   1800

aggggcaagt gggtgtccca ggtgacccgg ggctcagagg ccaacctggg agaaagggct   1860

tggatggaat tcctggaact ctgggagtga aaggattacc aggacctaaa ggcgaactgg   1920

ctctgagtgg tgagaaaggg gaccaaggtc ctccagggga tcctggctcc cctgggtccc   1980

caggacctgc aggaccagct ggaccacctg gctacggacc ccaaggagaa cctggtctcc   2040

agggcacgca aggagttcct ggggcccccg gaccacccgg agaagccggc cctaggggag   2100

agctcagtgt ttcaacacca gttccaggcc ctccaggacc tccagggccc cctggccatc   2160

ctggccccca aggtccacct ggtatccctg gatccctggg gaaatgtgga gatcctggtc   2220

ttccagggcc tgatggtgaa ccaggaattc caggaattgg atttcctggg ccacctggac   2280

ctaagggaga ccaaggtttt ccaggtacaa aaggatcact gggttgtcct ggaaaaatgg   2340

gagagcctgg gttacctgga aagccaggcc tcccaggagc caagggagaa ccagcagtag   2400

ccatgcctgg aggaccagga acaccaggtt ttccaggaga aagaggcaat tctggggaac   2460

atggagaaat tggactccct ggacttccag gtctccctgg aactccagga aatgaagggc   2520

ttgatggacc acgaggagat ccagggcagc ctggaccacc tggagaacaa ggacccccag   2580

gaaggtgcat agagggtccc aggggagccc aaggacttcc aggcttaaat ggattgaaag   2640

ggcaacaagg cagaagaggt aaaacggggc caaagggaga cccaggaatt ccaggcttgg   2700

atagatcagg atttcctgga gaaactggat caccaggaat tccaggtcat caaggtgaaa   2760

tgggaccact gggtcaaaga ggatatccag gaaatccggg aattttaggg ccaccaggtg   2820

aagatggagt gattgggatg atgggatttc ctggagccat tggccctcca gggccccctg   2880

ggaacccagg cacaccaggg cagaggggga gccctggaat tccaggagta aagggccaga   2940

gaggaacccc aggagccaag ggggaacaag gagataaagg aaatcccggg ccttcagaga   3000

tatcccacgt aataggggac aaaggagaac caggtctcaa aggattcgca ggaaatccag   3060

gtgagaaagg aaacagaggc gttccaggga tgccaggttt aaagggcctc aaaggactac   3120

ccggaccagc aggaccacca ggccccagag gagatttggg cagcactggg aatcctggag   3180

aaccaggact ccgtggtata ccaggaagca tggggaacat gggcatgcca ggttctaaag   3240

gaaaaagggg aactttggga ttcccaggtc gagcaggaag accaggcctc ccaggtattc   3300

atggtctcca gggagataag ggagagccag gttattcaga aggtacaagg ccaggaccac   3360

cgggaccaac gggggatcca ggactgccgg gtgatatggg aaagaaagga gaaatggggc   3420

aacctggccc acctggacat ttggggcctg ctggacctga gggagcccct ggaagtcctg   3480

gaagtcctgg cctcccagga aagccaggtc ctcatggtga tttgggtttt aaaggaatca   3540

aaggcctcct gggccctcca ggaatcagag gccctccagg tcttccagga tttccaggat   3600

ctcctggacc aatgggtata agaggtgacc aaggacgtga tggaattcct ggtccagccg   3660

gagaaaaggg agaaacgggt ttattgaggg cccctccagg cccaagaggg aaccctggtg   3720

ctcaaggagc caaaggagac aggggagccc caggttttcc tggcctcccg ggcagaaaag   3780

gggccatggg agatgctgga cctcgaggac ccacaggcat agaaggattc ccagggccac   3840

caggtctgcc cggtgcaatt atccctggcc agacaggaaa tcgtggtcca ccaggctcaa   3900

gaggaagccc aggtgcgcct ggtccccctg gacctccagg gagtcatgta ataggcataa   3960

aaggagacaa agggtctatg ggccaccctg gcccaaaagg tccacctgga actgcaggag   4020

acatgggacc accaggtcgt ctgggagcac caggtactcc aggtcttcca ggacccagag   4080

gtgatcctgg attccagggg tttccaggcg tgaaaggaga aaagggtaat cctggatttc   4140

taggatccat tggacctcca ggaccaattg ggccaaaagg accacctggt gtacgtggag   4200

accctggcac acttaagatt atctcccttc caggaagccc agggccacct ggcacacctg   4260

gagaaccagg gatgcaggga gaacctgggc caccagggcc acctggaaac ctaggaccct   4320

gtgggccaag aggtaagcca ggcaaggatg gaaaaccagg aactcctgga ccagctggag   4380

aaaaaggcaa caaaggttct aaaggagagc caggaccagc tggatcagat ggattgccag   4440

gtttgaaagg aaaacgtgga gacagtggat cacctgcaac ctggacaacg agaggctttg   4500

tcttcacccg acacagtcaa accacagcaa ttccttcatg tccagagggg acagtgccac   4560

tctacagtgg gttttctttt ctttttgtac aaggaaatca acgagcccac ggacaagacc   4620

ttgatgcact gtttgtgaag gtcctgcgat cgccatagcc gttcacagcc aaaccactga   4680

cattcctcca tgtcctcacg gctggatttc tctctggaaa ggattttcat tcatcatgaa   4740

agcctattcc atcaactgtg aaagctgggg aattagaaaa aataataagt cgctgtcagg   4800

tgtgcatgaa gaaaagacac tgaagctaaa aaagacatgc agaactgcta tttttcatcc   4860

taaagaacaa agtaatgaca gaacatgctg ttatttaggt atttttcttt aaccaaacaa   4920

tattgctcca tgatgactta gtacaaagtt tcaatttgtt tccccacaaa acaaagcaat   4980

tctttcaagt gcagttctgt gatctgggtc tctaatctgt gctgtttcaa agttctctgt   5040

ggcaaagcag caactattca caaaatatca ccaaaaacct attccactta catccaaggc   5100

actgtcacta cggtgattgt atgaagtttg aatgctgcac gttatgaaat atttggcccg   5160

ctggattccc acatttgtct tctttctgtc tttaagactc agggaggcta aatcagtgtt   5220

tgattgcccc gccaaccctt cctgaaactt cagaccctgg gtagggaaga gaaggggcat   5280

gtggtatctg gagcattgtg tatagaactg gattttcaga cctgctgagg accgtaaggc   5340

ctgatggaac acagaactga actgaggttc atggattttc caggactgtt tcaaacatgc   5400

ccattactaa cggcaaaagg gggattccct gatggaacca taataccctt ggaaatactg   5460

tatggttttg ttttgttttg ttggttttta aagatttttg tttgtttatt gaattcattc   5520

actgtagctc taaaatctgc ttgtatccaa gcatataaaa ttttccccct tagtgaatta   5580

gttttaaaat gatattgtta tatacatact atgaaatatg tataacttta acttctgttt   5640

taccagcata cgcacacaaa taacaagaat actacttatg aaatgtgcac tttatcctca   5700

ttccataaat gttggtgcat accttatgta agggagcagt tcaataatcc atgaaagaac   5760

ttaaggcatt tgttggttta tcagactcgg aatctatttt tctcattgct ctgaatatgt   5820

catcactcta ggttttacag atttattcct ttgttacttc tctaattctt cctttgtaaa   5880

aaaaaaaaaa gcaacacttt tttttatgtt atatgttgtc ttacaaacca tactgaaaga   5940

gtcattgttt aaaatcttaa tgtatcaaac tgtataactt ggccgctgta tgtcttaaaa   6000

cctgcttttc aatgtgttga tacattccca aggttactta attcaactta actatcatgt   6060

tattcagcac caagcatgtc caggcactgt actaacctac agagatgcta agagaaaaaa   6120

aagacttgtt tctgatctaa tatccagaaa aagtaactca ttgctctgta ataatctcac   6180

atatacagta gcttcctccc tctagttttt tcttccttgt cactgctgtt atatttcatc   6240

atgataattc agcaggccag taaggtaaaa ataaggtcta tgcctaggga aactcaggct   6300

tctagtttct cttagaaaag ctaagagaag ataaggtctg aataatagca gaaaaaccaa   6360

catctacaaa acattaaact agtgttatac cttgatgata acactattga tgagtcttag   6420

agtccagaca caaagagaca aagctttgaa gatgcttttg atctacctag gtggagttgg   6480

tggtgctgat atttaaattc aggctactgc ttcaatctca attgctttgt aagtgaaaac   6540

atgacccaga gacagacaga ctatggccat ggctcacatg gtttacatcc ttcactgctc   6600

acgtgtttgc tgtcaagcca tttttacagt ctgaaactaa gatgtgcagc atttcactta   6660

tttagattca cttaacaaac aaatttttct gctttaaaaa tgtcttattg tcccaaggta   6720

ctatagcgga tatagagcta gctaatctct acaaaccctc tgtaggccag tagttctcaa   6780

agtgtggtct ctggaagagc agtatcagca tcatctggga acttgtcaca gatgcagatt   6840

ctagggacca ctccagacct acagaatcag aaactcttgg gggagggccc gaaatatcta   6900

tgttttacca agcccaccac atgattctga tgtactctaa atactgagaa aacctgttct   6960

atcaatccaa gcacactccg caggcagtta ccagtacggc tggctacaac tgctccatcc   7020

gtgcctcttt ttaaagttca aactcacagg tgactctaag gttatctact tttactcata   7080

agtaaaagcc ctagactggt gctaatgtca aaccactggc ctccactcag gcctccatct   7140

tctcatgccc tcttaccagt atttaacttc tgaggaagac aagtgatgct aaaacctgaa   7200

ttccaatgaa gccatatgaa ccagctgtca gttgcacttc taagacttta cttagcagta   7260

aattatagct catgtgcatt atttcagata cttagcttat gagtagctta tacaattagt   7320

gaagattaat attacagatt aaatgtaact gttcttaaat tgggctcact tgattcacag   7380

cgtgcataca cagattgtga gaagtcttca gcaagataaa cattattaac taacttattt   7440

atgaagtatt aaaatgctta catttgaact tgatggctaa cttactaaga ttctctatgt   7500

atcaaatgta acttactgcg actaaactta atttaatatt tactctataa ccaaatgaaa   7560

tatatttaaa atatattgaa tattttatat tgttatatcc tgacaagatt gttaatattt   7620

taatgtacta atatttctgt caattatatc taaatattat tttattatat tgcctaagaa   7680

taaacatttg ttaaattgg                                                7699


<210>  1526
<211>  1498
<212>  PRT
<213>  Homosapiens

<400>  1526

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Asp 
    1475                 1480                 1485             


Ala Leu  Phe Val Lys Val Leu  Arg Ser Pro 
    1490                 1495             


<210>  1527
<211>  1020
<212>  DNA
<213>  Homosapiens

<400>  1527
atgtctgcgc atcgcttacc gtggagccgt tccagtgcgt gggccacgcg tccgcccttt     60

tccgcgtcac atgaccacga acactcttcc gctacggctc ccagaagggg ccagcccgcg    120

cctttcgcgc ttctgccctg gccctctgcg ggccgctccg ccggtgctgt ccctgggcgc    180

ctccgtgctc tcagccaacc acctctgaga gcgcccactc gagcgccccg ggagccagag    240

ggcgggggtc ctcgccggga ccctcctgtg ggcccagggg tgagtgttga cgtcttcccg    300

acccgcgacc tgccgcccga gctggctgcc aggcctatcg ccgccgccga gaccctccgg    360

ccaacaggga cccgcggtgg ccccggcccc cccggtagtg tctccctgac ccgagtcccg    420

tccccgggcc tcttgccttc aaccctggtc tttcctcctc cccgggacct tgagtccccg    480

aggagagcga gggagaggag cgtcttctgc aggtgttttt gggcgaacct cttcaccttg    540

tgtggttcgg cgtctccttt tgtgtattaa cccggacttt tccgactgga aaataggggt    600

ttgggaagca gcgggagtcc cgtgagcgtg aacgccgggc tttgcaggtc ttcactcatc    660

cttccctgcc aaggccctga caccttacag gctgacctta aacctgcctt gtttaaaagg    720

aggtttttgt gttgttttgt ggcaagtaca ttttggaaaa gaagggcctt gttggaagcc    780

caggttgtgg catcgcgggt ggctgcgggc caccctgtcc gtctgtgagc atccctgctc    840

gcagatgtgg ctgcaggcag ttgctctcgg gtttccttcc aggagctggg aagccggagg    900

aaagctgcgg ttcctgttcc gccgagcttc tgaccttcct ctgcaggacg tgtgctacta    960

ttactatcgt aaaagaacac ccctgtctac ctcccacaaa gttagaagca aagggcattc   1020


<210>  1528
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  1528

Met Ser Ala His Arg Leu Pro Trp Ser Arg Ser Ser Ala Trp Ala Thr 
1               5                   10                  15      


Arg Pro Pro Phe Ser Ala Ser His Asp His Glu His Ser Ser Ala Thr 
            20                  25                  30          


Ala Pro Arg Arg Gly Gln Pro Ala Pro Phe Ala Leu Leu Pro Trp Pro 
        35                  40                  45              


Ser Ala Gly Arg Ser Ala Gly Ala Val Pro Gly Arg Leu Arg Ala Leu 
    50                  55                  60                  


Ser Gln Pro Pro Leu Arg Ala Pro Thr Arg Ala Pro Arg Glu Pro Glu 
65                  70                  75                  80  


Gly Gly Gly Pro Arg Arg Asp Pro Pro Val Gly Pro Gly Val Ser Val 
                85                  90                  95      


Asp Val Phe Pro Thr Arg Asp Leu Pro Pro Glu Leu Ala Ala Arg Pro 
            100                 105                 110         


Ile Ala Ala Ala Glu Thr Leu Arg Pro Thr Gly Thr Arg Gly Gly Pro 
        115                 120                 125             


Gly Pro Pro Gly Ser Val Ser Leu Thr Arg Val Pro Ser Pro Gly Leu 
    130                 135                 140                 


Leu Pro Ser Thr Leu Val Phe Pro Pro Pro Arg Asp Leu Glu Ser Pro 
145                 150                 155                 160 


Arg Arg Ala Arg Glu Arg Ser Val Phe Cys Arg Cys Phe Trp Ala Asn 
                165                 170                 175     


Leu Phe Thr Leu Cys Gly Ser Ala Ser Pro Phe Val Tyr 
            180                 185                 


<210>  1529
<211>  2032
<212>  DNA
<213>  Homosapiens

<400>  1529
gttacttttt aaatggacaa aagtggctct caatccagca catgcacatt gaagcaagtt     60

aaaggattta atatgaagca cagaagcaga tagtgccaaa tagcaagcag tagttgttac    120

acatttctgg aaaagcagtg tccgtgttgt tatgtacacc tccaaaaaaa gttcaaatgt    180

gtaggggaat tgttgtgtaa agtaaactga actgcagggt agcagtattt taatagctat    240

tatagacctg tatttactgt atttaaatga gtaaaggaac aagcagtgac acatcactag    300

gaagggtgag cagggcagca tttccttctc ccactgctgc tgagatggca gaaattagtc    360

gaattcagta cgaaatggaa tatactgaag gcattagtca gcgaatgagg gtcccagaaa    420

agttaaaagt agcaccgcca aacgctgacc tggaacaagg attccaagaa ggagttccaa    480

atgctagtgt gataatgcaa gttccggaga ggattgttgt agcaggaaat aatgaagatg    540

tttcattttc aagaccagca gatcttgacc ttattcagtc aactcccttt aaacccctgg    600

cactgaaaac accacctcgt gtacttacgc tgagtgaaag accactagat tttctggatt    660

tagaaagacc tcctacaacc cctcaaaatg aagaaatccg agcagttggc agactaaaaa    720

gagagcggtc tatgagtgaa aatgctgttc gccaaaatgg acagctggtc agaaatgatt    780

ctctgtggca cagatcagat tctgccccaa gaaataaaat ttcaaggttc caggcaccga    840

tttctgcacc ggagtacact gtgacaccat cgccacaaca ggctcgggtc tgtcctcccc    900

atatgttacc tgaagatgga gctaatcttt cctctgctcg tggcattttg tcgcttatcc    960

agtcttctac tcgtagggca taccagcaga tcttggatgt gctggatgaa aatcgcagac   1020

ctgtgttgcg tggtgggtct gctgccgcca cttctaatcc tcatcatgac aacgtcaggt   1080

atggcatttc aaatatagat acaaccattg aaggaacgtc agatgacctg actgttgtag   1140

atgcagcttc actaagacga cagataatca aactaaatag acgtctacaa cttctggaag   1200

aggagaacaa agaacgtgct aaaagagaaa tggtcatgta ttcaattact gtagctttct   1260

ggctgcttaa tagctggctc tggtttcgcc gctagaggta acatcagccc tcaaaaatac   1320

tgtctcaaca gctggaaata taaaagattt gcaaacttct ttgtttctgt ctctgcattg   1380

tatgccattt tatagtccac accctgaaaa tgtatttctt ccagaaagtc tggaggaagg   1440

acctatattt gtagaagtaa aggtatattc tgtcactcag ctgtattcac gtctgagcag   1500

ttctgcagta acacctgctt aaaattctcc ctttgcatgt tttgtaaata ggctccagtt   1560

ttgtttttta aaaggaattt attttttgcc tcatcagtcc acccaactga ttctgaatgg   1620

gagagagtct gtagagaatt gattcagaaa agtgtctgtg aaagaaaaac aattattttg   1680

tcctgtttct caaacagtgt taagcagttt tgttaataga catttttgca tcgacacttc   1740

aacattaaca ctttgaaagt catggtctgg tgccagattt aagaaactcg aaccacctaa   1800

tatttcataa ccttcttcat taggtacttg tacagattaa tttctaacat tgcagcagtt   1860

tcatatgtgt gcaatatgtg cattctttca ttttagtttt gcacttggtt ttctataaag   1920

tacgttttta ctcagttcat gcgtgaacaa tttaaaaaac gacagaataa ggtacaaatg   1980

tagtgtattt aataaactgt caaccaaaga aaaaaaaaaa aaaaaaaaaa aa           2032


<210>  1530
<211>  342
<212>  PRT
<213>  Homosapiens

<400>  1530

Met Ser Lys Gly Thr Ser Ser Asp Thr Ser Leu Gly Arg Val Ser Arg 
1               5                   10                  15      


Ala Ala Phe Pro Ser Pro Thr Ala Ala Glu Met Ala Glu Ile Ser Arg 
            20                  25                  30          


Ile Gln Tyr Glu Met Glu Tyr Thr Glu Gly Ile Ser Gln Arg Met Arg 
        35                  40                  45              


Val Pro Glu Lys Leu Lys Val Ala Pro Pro Asn Ala Asp Leu Glu Gln 
    50                  55                  60                  


Gly Phe Gln Glu Gly Val Pro Asn Ala Ser Val Ile Met Gln Val Pro 
65                  70                  75                  80  


Glu Arg Ile Val Val Ala Gly Asn Asn Glu Asp Val Ser Phe Ser Arg 
                85                  90                  95      


Pro Ala Asp Leu Asp Leu Ile Gln Ser Thr Pro Phe Lys Pro Leu Ala 
            100                 105                 110         


Leu Lys Thr Pro Pro Arg Val Leu Thr Leu Ser Glu Arg Pro Leu Asp 
        115                 120                 125             


Phe Leu Asp Leu Glu Arg Pro Pro Thr Thr Pro Gln Asn Glu Glu Ile 
    130                 135                 140                 


Arg Ala Val Gly Arg Leu Lys Arg Glu Arg Ser Met Ser Glu Asn Ala 
145                 150                 155                 160 


Val Arg Gln Asn Gly Gln Leu Val Arg Asn Asp Ser Leu Trp His Arg 
                165                 170                 175     


Ser Asp Ser Ala Pro Arg Asn Lys Ile Ser Arg Phe Gln Ala Pro Ile 
            180                 185                 190         


Ser Ala Pro Glu Tyr Thr Val Thr Pro Ser Pro Gln Gln Ala Arg Val 
        195                 200                 205             


Cys Pro Pro His Met Leu Pro Glu Asp Gly Ala Asn Leu Ser Ser Ala 
    210                 215                 220                 


Arg Gly Ile Leu Ser Leu Ile Gln Ser Ser Thr Arg Arg Ala Tyr Gln 
225                 230                 235                 240 


Gln Ile Leu Asp Val Leu Asp Glu Asn Arg Arg Pro Val Leu Arg Gly 
                245                 250                 255     


Gly Ser Ala Ala Ala Thr Ser Asn Pro His His Asp Asn Val Arg Tyr 
            260                 265                 270         


Gly Ile Ser Asn Ile Asp Thr Thr Ile Glu Gly Thr Ser Asp Asp Leu 
        275                 280                 285             


Thr Val Val Asp Ala Ala Ser Leu Arg Arg Gln Ile Ile Lys Leu Asn 
    290                 295                 300                 


Arg Arg Leu Gln Leu Leu Glu Glu Glu Asn Lys Glu Arg Ala Lys Arg 
305                 310                 315                 320 


Glu Met Val Met Tyr Ser Ile Thr Val Ala Phe Trp Leu Leu Asn Ser 
                325                 330                 335     


Trp Leu Trp Phe Arg Arg 
            340         


<210>  1531
<211>  2308
<212>  DNA
<213>  Homosapiens

<400>  1531
aagccacttt gacaacgttt ctgagccagg ggtgaccatg acctgctgcg aaggatggac     60

atcctgcaat ggattcagcc tgctggttct actgctgtta ggagtagttc tcaatgtgat    120

acctctaatt gtcagcttag ttgaggaaga ccaattttct caaaacccca tctcttgctt    180

tgagtggtgg ttcccaggaa ttataggagc aggtctgatg gccattccag caacaacaat    240

gtccttgaca gcaagaaaaa gagcgtgctg caacaacaga actggaatgt ttctttcatc    300

acttttcagt gtgatcacag tcattggtgc tctgtattgc atgctgatat ccatccaggc    360

tctcttaaaa ggtcctctca tgtgtaattc tccaagcaac agtaatgcca attgtgaatt    420

ttcattgaaa aacatcagtg acattcatcc agaatccttc aacttgcagt ggtttttcaa    480

tgactcttgt gcacctccta ctggtttcaa taaacccacc agtaacgaca ccatggcgag    540

tggctggaga gcatctagtt tccacttcga ttctgaagaa aacaaacata ggcttatcca    600

cttctcagta tttttaggtc tattgcttgt tggaattctg gaggtcctgt ttgggctcag    660

tcagatagtc atcggtttcc ttggctgtct gtgtggagtc tctaagcgaa gaagtcaaat    720

tgtgtagttt aatgggaata aaatgtaagt atcagtagtt tgaattaatt tgagaagtac    780

acttgttttc aaagtcatct ttgagatgat ttaaaaaatc aacccttcac gtagaaagca    840

cgttgtaaat gcataacact ctcatatcag tggttgattt gggaaaggtg gagagaattt    900

tcaattagtt ttgtgttgta ctattcaaat tttttacctc ttcactgtgt gtagagaaag    960

gagaagggaa ggaggatgag aaggaacgga agtcatcctg aaaataaaag tacaggactt   1020

tttttttttt tttttgagac agggtctcaa aaaaggctgg agtacagtag tacagtggtg   1080

ctatctcagc ttactgcagc ctcaacctcc tgggctcagg tgattctccc atctcagcct   1140

ccctagtagc tgggactaca ggtgcgtgcc actatgccaa gctaattttt gtatttttag   1200

tagagatggg ggttttccat attgcccagg ctggtcccga actcatggac tcaagtgatc   1260

tgcctgcctc agcctcctaa agtgctgcga ttacaggcat gagccatcgc gcctaaagga   1320

caggaccttt ttattgtatt tctttaaaga ataaatacat aacctgaatg caatcaagtc   1380

tttagatcta attctcagct tgcagggaac actaggacaa atccaaaaag tgggtcagcg   1440

ggcacagaat ggcccaattt tcaacaggaa aatgttataa aagaaaaata tttttgaggg   1500

aactgttata gattaagaga atagaggcat gtttcagcta aacacatgta aactttgtca   1560

gagataattg ggaggagtat gtagaagaat cggattattg ttaattttgg taggtctgat   1620

aatggtttta tagtataaag gctgagtacc ccttatccaa aatgattaag atcagaagtg   1680

ttttggcttt cacatttttt tggattttgg aattttgcct ataataatga gacatcttgg   1740

ggatgggatg caagtctaac cacaaaattc atttatgtct catacacact ttgaacacct   1800

ggcctgaagg taatttcaca caatatttta aataactttg tgcatgaaac acaattttga   1860

ctgcattttg actgcaactc atcacatgag gtcaggtatg gaattttcca cttgtggtgt   1920

tacgttactg gctcaaaaag ttttggatct cggagcattc tggattttga atttttggat   1980

tagtgatgct caacctgtat acagaaatgt cctcattttt aaaaaaagaa atgcatattt   2040

atatgtttta aaattacttc aaccaaaagc aacggggaga tgtttactgt tatatttagg   2100

tgacaggtac atggcaattc attataccct cctattttcc tatgtttaca ttattcatta   2160

attaaaaaac aatacctaga aaaacccaag actttcaaaa gctattttct atatgtgcca   2220

atctttaaaa aacaggataa caagggtatt tatcacatta aaatgttgta aaacagcaaa   2280

gctaaaatct aaaaaaaaaa aaaaaaaa                                      2308


<210>  1532
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  1532

Met Thr Cys Cys Glu Gly Trp Thr Ser Cys Asn Gly Phe Ser Leu Leu 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Val Val Leu Asn Val Ile Pro Leu Ile Val 
            20                  25                  30          


Ser Leu Val Glu Glu Asp Gln Phe Ser Gln Asn Pro Ile Ser Cys Phe 
        35                  40                  45              


Glu Trp Trp Phe Pro Gly Ile Ile Gly Ala Gly Leu Met Ala Ile Pro 
    50                  55                  60                  


Ala Thr Thr Met Ser Leu Thr Ala Arg Lys Arg Ala Cys Cys Asn Asn 
65                  70                  75                  80  


Arg Thr Gly Met Phe Leu Ser Ser Leu Phe Ser Val Ile Thr Val Ile 
                85                  90                  95      


Gly Ala Leu Tyr Cys Met Leu Ile Ser Ile Gln Ala Leu Leu Lys Gly 
            100                 105                 110         


Pro Leu Met Cys Asn Ser Pro Ser Asn Ser Asn Ala Asn Cys Glu Phe 
        115                 120                 125             


Ser Leu Lys Asn Ile Ser Asp Ile His Pro Glu Ser Phe Asn Leu Gln 
    130                 135                 140                 


Trp Phe Phe Asn Asp Ser Cys Ala Pro Pro Thr Gly Phe Asn Lys Pro 
145                 150                 155                 160 


Thr Ser Asn Asp Thr Met Ala Ser Gly Trp Arg Ala Ser Ser Phe His 
                165                 170                 175     


Phe Asp Ser Glu Glu Asn Lys His Arg Leu Ile His Phe Ser Val Phe 
            180                 185                 190         


Leu Gly Leu Leu Leu Val Gly Ile Leu Glu Val Leu Phe Gly Leu Ser 
        195                 200                 205             


Gln Ile Val Ile Gly Phe Leu Gly Cys Leu Cys Gly Val Ser Lys Arg 
    210                 215                 220                 


Arg Ser Gln Ile Val 
225                 


<210>  1533
<211>  4878
<212>  DNA
<213>  Homosapiens

<400>  1533
gcggccgcgg ccagggcggc ccgtgggacc gcgggccccc ggcgcagcgc tgcccggctc     60

ccggccctgc cggcctcctc ccttggcgcc gcggccatgg cggccagcgc gaagcggaag    120

caggaggaga agcacctgaa gatgctgcgg gacatgaccg gcctcccgca caaccgaaag    180

tgcttcgact gcgaccagcg cggccccacc tacgttaaca tgacggtcgg ctccttcgtg    240

tgtacctcct gctccggcag cctgcgagga ttaaatccac cacacagggt gaaatctatc    300

tccatgacaa cattcacaca acaggaaatt gaattcttac aaaaacatgg aaatgaagtc    360

tgtaaacaga tttggctagg attatttgat gatagatctt cagcaattcc agacttcagg    420

gatccacaaa aagtgaaaga gtttctacaa gaaaagtatg aaaagaaaag atggtatgtc    480

ccgccagaac aagccaaagt cgtggcatca gttcatgcat ctatttcagg gtcctctgcc    540

agtagcacaa gcagcacacc tgaggtcaaa ccactgaaat ctcttttagg ggattctgca    600

ccaacactgc acttaaataa gggcacacct agtcagtccc cagttgtagg tcgttctcaa    660

gggcagcagc aggagaagaa gcaatttgac cttttaagtg atctcggctc agacatcttt    720

gctgctccag ctcctcagtc aacagctaca gccaattttg ctaactttgc acatttcaac    780

agtcatgcag ctcagaattc tgcaaatgca gattttgcaa actttgatgc atttggacag    840

tctagtggtt cgagtaattt tggaggtttc cccacagcaa gtcactctcc ttttcagccc    900

caaactacag gtggaagtgc tgcatcagta aatgctaatt ttgctcattt tgataacttc    960

cccaaatcct ccagtgctga ttttggaacc ttcaatactt cccagagtca tcaaacagca   1020

tcagctgtta gtaaagtttc aacgaacaaa gctggtttac agactgcaga caaatatgca   1080

gcacttgcta atttagacaa tatcttcagt gccgggcaag gtggtgatca gggaagtggc   1140

tttgggacca caggtaaagc tcctgttggt tctgtggttt cagttcccag tcagtcaagt   1200

gcatcttcag acaagtatgc agctctggca gaactagaca gcgttttcag ttctgcagcc   1260

acctccagta atgcgtatac ttccacaagt aatgctagca gcaatgtttt tggaacagtg   1320

ccagtggttg cttctgcaca gacacagcct gcttcatcaa gtgtgcctgc tccatttgga   1380

gctacgcctt ccacaaatcc atttgttgct gctgctggtc cttctgtggc atcttctaca   1440

aacccatttc agaccaatgc cagaggagca acagcggcaa cctttggcac tgcatccatg   1500

agcatgccca caggattcgg cactcctgct ccctacagtc ttcccaccag ctttagtggc   1560

agctttcagc agcctgcctt tccagcccaa gcagctttcc ctcaacagac agctttttct   1620

caacagccca atggtgcagg ttttgcagca tttggacaaa caaagccagt agtaacccct   1680

tttggtcaag ttgcagctgc tggagtatct agtaatcctt ttatgactgg tgcaccaaca   1740

ggacaatttc caacaggaag ctcatcaacc aatcctttct tatagcctta tatagacaat   1800

ttactggaac gaacttttat gtggtcacat tacatctctc cacctcttgc actgttgtct   1860

tgtttcactg atcttagctt taaacacaag agaagtcttt aaaaagcctg cattgtgtat   1920

taaacaccag gtaatatgtg caaaaccgag ggctccagta acaccttcta acctgtgaat   1980

tggcagaaaa gggtagcggt atcatgtata ttaaaattgg ctaatattaa gttattgcag   2040

ataccacatt cattatgctg cagtactgta catatttttc ttagaaatta gctatttgtg   2100

catatcagta tttgtaactt taacacattg ttatgtgaga aatgttactg gggaaataga   2160

tcagccactt ttaaggtgct gtcatatatc ttggaatgaa tgacctaaaa tcattttaac   2220

cattgctact ggaaagtaac agagtcaaaa ttggaaggtt ttattcattc ttgaattttt   2280

cctttctaaa gagctcttct atttatacat gcctaaattc ttttaaaatg tagagggata   2340

cctgtctgca taataaagct gatcatgttt tgctacagtt tgcaggtgaa aaaaaataaa   2400

tattataaaa tatgctattg tttttgtgtt cttgctgcaa tgcctttacc aaagtggcct   2460

taaatatgag tagtgaattg agaacatctt gaattcttaa aagacttctt agtgactttt   2520

tataaaaagg ccatgtagaa aatttattaa aactactatg actgctacat tcaggaatat   2580

gccagtggta aagcatttaa atgtagcttg tcagatttac cataatccta ctaatttctt   2640

tgcagcttat taattttgtg aaatttgtat atatgaagaa tttgcatgta tgtgtattta   2700

caaatttttc taagtatctt gaattctcag actgcaaaag gcctatttta actattgatt   2760

ttttttaaaa aaaattgtct ttgaatgtat tggaagtaga catgcattaa ctgtgacatt   2820

attgcacctc agtttttttc tttctttttt tgggcaaact gatattatct ataggatatt   2880

tgtttatgtt tgttttttgg gggaaagaaa ctggaactca gtgttacctt aaagttacgg   2940

aatactttgt tttaaaggaa aagataataa gtttagttat atctttttgt taatattcaa   3000

atgaacttgt ttaagtatct atgtacagta atgcctcatt catctagagg taatctggca   3060

gtcttgtgaa aaccgaacac aactcagaaa cttggaatcg ttttttttaa aaatgcctct   3120

gagcaaccca tataagtcac aaagtctgtg tgttagagct tatgcatttg tttttatgag   3180

agattttaat aaatttaatt atttgcttgt ccagactata gcatattagc tgtttagaag   3240

ggatggcttg aaaggaagga gactgaaaaa cactctgaga gcatacactg tccaaggcca   3300

ttagtgtaag gaccgctacc cagcctagag gacatcacta tactacatca tctgatgatt   3360

attctttatt atgcctctag gtaattaagt aaaggtgaaa ttgcatacac agatatgtag   3420

tacatatttt aaaagtttta tcttaaattg attaaaactt tttaaaaagc tttggtatta   3480

aaagaggtaa acatcagttt cctcaaacat tttattcatg ttgaatgcct ttttgcaatg   3540

atgactgagt tgttatcata gtattttaaa acctgtatag tgttttagac ttgttaaaac   3600

attgctgtct agtgtacatc tagctaaaag tgtggtttat ctaaaccgtt ttaataagca   3660

agatgactgg gaaatctctg ccccttttct gagcagtatg cctcttcttt tagaattaaa   3720

tgaatgctgc acaggtccag atgtgtgttg atgtagactt gaaatgtctc cacattttgg   3780

aggacttcct cagccctttt cattgaggga aaatatattt gaatttctgt tttagattgt   3840

atcgggtccc agttgattca tgtgtacaaa gttatgctac ctaattacag accattaccc   3900

aaatatccta ccaggctttc catctgaata gtaaattaaa cagttgttat caaaatgatt   3960

ttaaagacta tttctttttc tgggtaacta ttgaagtttg taattaaatg ggggctctta   4020

ctgactttaa attagcgctt ataaaataaa aatgtttagt tcaagaagag acccaagctg   4080

ggtatggtgg tgtgagagcc tgtgagtcct agctacctgg aggtgaggtg ggaacatcac   4140

ttgagcccag gagttggagg ctgcagtgcg ctacgatcac accactgcac accagcctgg   4200

ggatagagtg agatcccatc tctaaaaaat gaaaaaaaga agagaggtag ctttaaagtg   4260

gtttttctca tgatattcac tgtttattat taaagaaaat cagctttcgt tagactttta   4320

catttagatt tattctagtt ttatatagac catcaaaatt atgttgagta ctaaaaagga   4380

gaaaaaatcc tggaaggtaa caaggctgaa gaccttcaaa tttcctggct tactggttta   4440

gtcacatcat ttttcctgtt caggtatctg cagatatccc tgttcaggaa agatcttttt   4500

tcaggatggc aaacttttga catagtttaa agacattttt tccccatttt ttgaaataga   4560

gaatatttta ttatttttgt gaaaatagag ttttggtaat cactttcttc ctcaaaataa   4620

gtccttctgt taatttgtaa aagcacatta gtgctttacc tgtgaaattc cccgcccccc   4680

tgcacacaca cccactttag tacagttcct gtcaattggc aacatggaga gggtgacctg   4740

gctgctggtt taccactgta ccaacatctc tggagcattt tagtttcaga accttaacac   4800

tccccaacag ctttgttgat gtagcttgta tctctgagaa tttattgtat taaaattaat   4860

actgagatat ttttaaaa                                                 4878


<210>  1534
<211>  562
<212>  PRT
<213>  Homosapiens

<400>  1534

Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp Phe 
225                 230                 235                 240 


Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe Gly 
                245                 250                 255     


Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr Gly 
            260                 265                 270         


Gly Ser Ala Ala Ser Val Asn Ala Asn Phe Ala His Phe Asp Asn Phe 
        275                 280                 285             


Pro Lys Ser Ser Ser Ala Asp Phe Gly Thr Phe Asn Thr Ser Gln Ser 
    290                 295                 300                 


His Gln Thr Ala Ser Ala Val Ser Lys Val Ser Thr Asn Lys Ala Gly 
305                 310                 315                 320 


Leu Gln Thr Ala Asp Lys Tyr Ala Ala Leu Ala Asn Leu Asp Asn Ile 
                325                 330                 335     


Phe Ser Ala Gly Gln Gly Gly Asp Gln Gly Ser Gly Phe Gly Thr Thr 
            340                 345                 350         


Gly Lys Ala Pro Val Gly Ser Val Val Ser Val Pro Ser Gln Ser Ser 
        355                 360                 365             


Ala Ser Ser Asp Lys Tyr Ala Ala Leu Ala Glu Leu Asp Ser Val Phe 
    370                 375                 380                 


Ser Ser Ala Ala Thr Ser Ser Asn Ala Tyr Thr Ser Thr Ser Asn Ala 
385                 390                 395                 400 


Ser Ser Asn Val Phe Gly Thr Val Pro Val Val Ala Ser Ala Gln Thr 
                405                 410                 415     


Gln Pro Ala Ser Ser Ser Val Pro Ala Pro Phe Gly Ala Thr Pro Ser 
            420                 425                 430         


Thr Asn Pro Phe Val Ala Ala Ala Gly Pro Ser Val Ala Ser Ser Thr 
        435                 440                 445             


Asn Pro Phe Gln Thr Asn Ala Arg Gly Ala Thr Ala Ala Thr Phe Gly 
    450                 455                 460                 


Thr Ala Ser Met Ser Met Pro Thr Gly Phe Gly Thr Pro Ala Pro Tyr 
465                 470                 475                 480 


Ser Leu Pro Thr Ser Phe Ser Gly Ser Phe Gln Gln Pro Ala Phe Pro 
                485                 490                 495     


Ala Gln Ala Ala Phe Pro Gln Gln Thr Ala Phe Ser Gln Gln Pro Asn 
            500                 505                 510         


Gly Ala Gly Phe Ala Ala Phe Gly Gln Thr Lys Pro Val Val Thr Pro 
        515                 520                 525             


Phe Gly Gln Val Ala Ala Ala Gly Val Ser Ser Asn Pro Phe Met Thr 
    530                 535                 540                 


Gly Ala Pro Thr Gly Gln Phe Pro Thr Gly Ser Ser Ser Thr Asn Pro 
545                 550                 555                 560 


Phe Leu 
        


<210>  1535
<211>  1860
<212>  DNA
<213>  Homosapiens

<400>  1535
ttttgtattt gaatgcgcat gtgtgtgtcc ttttaaaact ctttccattt gtacaatgac     60

agatttcaga ttggagttaa tctgagcatg gaagactatg ccctgacgtt tggaattaat    120

cccttcattg ccttgatgat tcaacccatc gtgacgatga ctgtggttga caaccaagga    180

ctggggcttc ctgttgacat tcagcacaaa gcaaagccct cgccaaaagc cagccagatg    240

ctgccacctg atcttggacc tcccagcttc cagaacttat taagtccatc tgagaaacta    300

gagccttggg acccagggat gaggaaactt accgtacaga catgcgggct gaccttcatt    360

caccctgcgg gccatggcct ctgccatcca actgcacagg cttcagccga aactctctcc    420

agcactgccc taaacagacc aagtgtgagg gagggagcat gtaatgaaaa gtccacagag    480

aacaagaagc cacaagattc ggtgctctgg agccattcta gatggtttca ggggaactag    540

cttcccacct ctgacaggga taccatggca aataccactc tttgcctagg attataattc    600

tttgtgcaca atgcatccca tcccaaagac agtccacagc aggacttgct ccatctctga    660

actggtctta cccccttaaa cctgccttta tatctaggag tttctttatt ttattttatt    720

tttttgagac agagtctcgc tccattgccc aggctggact gcagcggcgt gatctcagct    780

cactgcaacc tccacctcct gggttcaagt gattcttgtg cctcagcctc ccaagtagct    840

gggattaaag gcacgtgcca ccatgactgg ccaattttta tatttttagt agagatgagg    900

tttcaccatg ttggccaggc tggtctcaaa ctcttgactt caagtgatcc gcccgcctca    960

gcctcccaaa gtgctgggat tacaggtgtg agccaccagg cccagcctat atctaggagt   1020

ctcttgatga gcattggtcg acagaaagaa gtctcttcta aaaattgtta atgcttttat   1080

agactactca tagtctgagt cataaaacat catttgcctt tcaatttata ccttccaagt   1140

gaatatgatt attgaggatt atctaattat tatctacttt tctctctaga tataaaaaac   1200

accatagatc ctatacacac aaaaatggtt tttctatcag aaatggactc actcgcctgg   1260

caaaaggaca cagattagat tattctaatc tcaaggcccc ttaggcttat gaattcaaaa   1320

aaaaaaatag aagaaatgaa caaaaacata aatcacagtt tgttattaag taatatctga   1380

aatgaattag aaagaaacca taagccttaa caatactcca atcacagtta aattaattta   1440

gacagaaaag caaatagcaa ttgacttgaa aataagaagt ggagccgaag gtggatacaa   1500

gaaatccagg agggctaaga tatatcccaa atccaatgtt catcaatgcc tacacattca   1560

gtacaacctg atggcattaa ttctgtggtt ggggaaatgt gaaagtgaaa tcgataatac   1620

cacagttcta aatgtgcact gttggctgaa cttatggtgt ggtggggggt ggtaaaaatt   1680

aggcttctaa gaaaggatgg gactctgccc tccaggcaag gagtaaatgg ccccagcaga   1740

tggaaaacta aagcaaatgt aatcacctgc attttgaaaa taggtgtgtt tctgagaatt   1800

tgtttgaatt agttctttgt aaataaaaca ggattttgaa tgcaaaaaaa aaaaaaaaaa   1860


<210>  1536
<211>  150
<212>  PRT
<213>  Homosapiens

<400>  1536

Met Glu Asp Tyr Ala Leu Thr Phe Gly Ile Asn Pro Phe Ile Ala Leu 
1               5                   10                  15      


Met Ile Gln Pro Ile Val Thr Met Thr Val Val Asp Asn Gln Gly Leu 
            20                  25                  30          


Gly Leu Pro Val Asp Ile Gln His Lys Ala Lys Pro Ser Pro Lys Ala 
        35                  40                  45              


Ser Gln Met Leu Pro Pro Asp Leu Gly Pro Pro Ser Phe Gln Asn Leu 
    50                  55                  60                  


Leu Ser Pro Ser Glu Lys Leu Glu Pro Trp Asp Pro Gly Met Arg Lys 
65                  70                  75                  80  


Leu Thr Val Gln Thr Cys Gly Leu Thr Phe Ile His Pro Ala Gly His 
                85                  90                  95      


Gly Leu Cys His Pro Thr Ala Gln Ala Ser Ala Glu Thr Leu Ser Ser 
            100                 105                 110         


Thr Ala Leu Asn Arg Pro Ser Val Arg Glu Gly Ala Cys Asn Glu Lys 
        115                 120                 125             


Ser Thr Glu Asn Lys Lys Pro Gln Asp Ser Val Leu Trp Ser His Ser 
    130                 135                 140                 


Arg Trp Phe Gln Gly Asn 
145                 150 


<210>  1537
<211>  3177
<212>  DNA
<213>  Homosapiens

<400>  1537
caggacgaag tttttggctg tgggctctct gggacagagt ggagcgcctg tggatttagc     60

cggggacaca ccatcctgct cgcaggtgcc tggacaggac aggggacgag ggaggaacac    120

tctctgagga agcccaactc ctatgagctc ctctctggca gcactcaaac cagtgaagct    180

tgggaaagtc attgacctcc agtcgttctg ctgagaaaca tctggctcta tttccatgga    240

gaccagggaa tctgaagatt tggaaaagac ccggaggaaa tcagcaagtg atcaatggaa    300

cactgataat gaaccagcca aggtgaaacc tgagttactc ccagaaaaag aggagacttc    360

tcaagctgac caggatatcc aagacaaaga gcctcattgc cacatcccaa ttaagagaaa    420

ttccatcttc aatcgctcca taagacgcaa aagcaaagcc aaggccagag acaaccccga    480

acggaacgcc agctgcctgg cagattcaca ggacaatgga aaatctgtaa atgagcccct    540

gaccttgaat atcccctgga gcagaacgcc tccttgcaga acagcaatgc agacagaccc    600

aggagcccag gaaatgagtg agtcgtcctc caccccggga aatggggcca cgcccgagga    660

gtggccggcc ctggccgaca gccccaccac gctcaccgag gccctgcgga tgatccaccc    720

cattcccgcc gactcctgga gaaacctcat tgaacaaata gggctcctgt atcaggaata    780

ccgagataaa tcgactctcc aagaaatcga aaccaggagg caacaggatg cagaaataga    840

agacaatacc aatgggtccc cggccagtga ggacaccccg gaggaggaag aagaagagga    900

ggaggaggag gagccggcca gcccaccaga gaggaagact ctgccccaga tctgcctgct    960

cagtaacccc cactcaaggt tcaacctctg gcaggatctt cccgagatcc ggagcagcgg   1020

ggtgcttgag atcctacagc ctgaggagat taagctgcag gaggccatgt tcgagctggt   1080

cacttccgag gcgtcctact acaagagtct gaacctgctc gtgtcccact tcatggagaa   1140

cgagcggata aggaagatcc tgcacccgtc cgaggcgcac atcctcttct ccaacgtcct   1200

ggacgtgctg gctgtcagtg agcggttcct cctggagctg gagcaccgga tggaggagaa   1260

catcgtcatc tctgacgtgt gtgacatcgt gtaccgttat gcggctgacc acttctctgt   1320

ctacatcacc tacgtcagca atcagaccta ccaggagcgg acctataagc agctgctcca   1380

ggagaaggca gctttccggg agctgatcgc gcagctagag ctcgacccca agtgcagggg   1440

gctgcccttc tcctccttcc tcatcctgcc tttccagagg atcacacgcc tcaagctgtt   1500

ggtccagaac atcctgaaga gggtagaaga gaggtctgag cgggagtgca ctgctttgga   1560

tgctcacaag gagctggaaa tggtggtgaa ggcatgcaac gagggcgtca ggaaaatgag   1620

ccgcacggaa cagatgatca gcattcagaa gaagatggag ttcaagatca agtcggtgcc   1680

catcatctcc cactcccgct ggctgctgaa gcagggtgag ctgcagcaga tgtcaggccc   1740

caagacctcc cggaccctga ggaccaagaa gctcttccac gaaatttacc tcttcctgtt   1800

caacgacctg ctggtgatct gccggcagat tccaggagac aagtaccagg tatttgactc   1860

agctccgcgg ggactgctgc gtgtggagga gctggaggac cagggccaga cgctggccaa   1920

cgtgttcatc ctgcggctgc tggagaacgc agatgaccgg gaggccacct acatgctaaa   1980

ggcgtcctct cagagtgaga tgaagcgttg gatgacctca ctggccccca acaggaggac   2040

caagtttgtt tcgttcacat cccggctgct ggactgcccc caggtccagt gcgtgcaccc   2100

atacgtggct cagcagccag acgagctgac gctggagctc gccgacatcc tcaacatcct   2160

ggacaagact gacgacgggt ggatctttgg cgagcgtctg cacgaccagg agagaggctg   2220

gttccccagc tccatgactg aggagatctt gaatcccaag atccggtccc agaacctcaa   2280

ggaatgtttc cgtgtccaca agatggatga ccctcagcgc agccagaaca aggaccgcag   2340

gaagctgggc agccggaatc ggcaatgacc cccacccagg gggccagcgg gagcagggcc   2400

tgcatgagac cccgacagaa ggtggggggg gggcctctgg gaagcacagg ccagcacctc   2460

cccaggtggc aggatctggc ttggggtgcc cggccctcat ccctgcccac gcagtgagtg   2520

ctcatgtgtc ttggcccctt gcttgcaaac tggataaagg gtgcccaagc ctctcctgat   2580

gcatttgtaa acaagaaggt ttcagcagta ttacaccacc tccctcatgc ctccgagggg   2640

gtggaagggg gtgggcacac tccagggccc cccatgcccc tggcccccag ggactggaag   2700

aggctcccaa cccagagtgt ccctgtggga ggcaggcaga aggtgacaat tgacacgatt   2760

tcctgcacgc gtcctcctct accttggaag cagttagaat ctaccaggca cagatgaggc   2820

cgcccttgcc tgacggagct tgatgagcag cccttggtct ccggttccag gactgagagc   2880

ccagctgcct ctgcccaccc ttccccaggc ctctgccagc ctctggctgc acggtcaggc   2940

cctgccccat ggcaggcctg ccagagcttg gctggggacc cctcccgcct ctggctccct   3000

gatgggctgg atgtaacttg tgtcttctag ccgcttaagg agcccaggtg ttttaaggaa   3060

tgaattggtc actgcatctt gtatcgatta tggttctgag aaaagcaaat atcacttttg   3120

gctgcattaa aagaagcatc atatataaaa taaaaaaaaa aaaaaaaaaa aaaaaaa      3177


<210>  1538
<211>  710
<212>  PRT
<213>  Homosapiens

<400>  1538

Met Glu Thr Arg Glu Ser Glu Asp Leu Glu Lys Thr Arg Arg Lys Ser 
1               5                   10                  15      


Ala Ser Asp Gln Trp Asn Thr Asp Asn Glu Pro Ala Lys Val Lys Pro 
            20                  25                  30          


Glu Leu Leu Pro Glu Lys Glu Glu Thr Ser Gln Ala Asp Gln Asp Ile 
        35                  40                  45              


Gln Asp Lys Glu Pro His Cys His Ile Pro Ile Lys Arg Asn Ser Ile 
    50                  55                  60                  


Phe Asn Arg Ser Ile Arg Arg Lys Ser Lys Ala Lys Ala Arg Asp Asn 
65                  70                  75                  80  


Pro Glu Arg Asn Ala Ser Cys Leu Ala Asp Ser Gln Asp Asn Gly Lys 
                85                  90                  95      


Ser Val Asn Glu Pro Leu Thr Leu Asn Ile Pro Trp Ser Arg Thr Pro 
            100                 105                 110         


Pro Cys Arg Thr Ala Met Gln Thr Asp Pro Gly Ala Gln Glu Met Ser 
        115                 120                 125             


Glu Ser Ser Ser Thr Pro Gly Asn Gly Ala Thr Pro Glu Glu Trp Pro 
    130                 135                 140                 


Ala Leu Ala Asp Ser Pro Thr Thr Leu Thr Glu Ala Leu Arg Met Ile 
145                 150                 155                 160 


His Pro Ile Pro Ala Asp Ser Trp Arg Asn Leu Ile Glu Gln Ile Gly 
                165                 170                 175     


Leu Leu Tyr Gln Glu Tyr Arg Asp Lys Ser Thr Leu Gln Glu Ile Glu 
            180                 185                 190         


Thr Arg Arg Gln Gln Asp Ala Glu Ile Glu Asp Asn Thr Asn Gly Ser 
        195                 200                 205             


Pro Ala Ser Glu Asp Thr Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Pro Ala Ser Pro Pro Glu Arg Lys Thr Leu Pro Gln Ile Cys 
225                 230                 235                 240 


Leu Leu Ser Asn Pro His Ser Arg Phe Asn Leu Trp Gln Asp Leu Pro 
                245                 250                 255     


Glu Ile Arg Ser Ser Gly Val Leu Glu Ile Leu Gln Pro Glu Glu Ile 
            260                 265                 270         


Lys Leu Gln Glu Ala Met Phe Glu Leu Val Thr Ser Glu Ala Ser Tyr 
        275                 280                 285             


Tyr Lys Ser Leu Asn Leu Leu Val Ser His Phe Met Glu Asn Glu Arg 
    290                 295                 300                 


Ile Arg Lys Ile Leu His Pro Ser Glu Ala His Ile Leu Phe Ser Asn 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Val Ser Glu Arg Phe Leu Leu Glu Leu Glu 
                325                 330                 335     


His Arg Met Glu Glu Asn Ile Val Ile Ser Asp Val Cys Asp Ile Val 
            340                 345                 350         


Tyr Arg Tyr Ala Ala Asp His Phe Ser Val Tyr Ile Thr Tyr Val Ser 
        355                 360                 365             


Asn Gln Thr Tyr Gln Glu Arg Thr Tyr Lys Gln Leu Leu Gln Glu Lys 
    370                 375                 380                 


Ala Ala Phe Arg Glu Leu Ile Ala Gln Leu Glu Leu Asp Pro Lys Cys 
385                 390                 395                 400 


Arg Gly Leu Pro Phe Ser Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile 
                405                 410                 415     


Thr Arg Leu Lys Leu Leu Val Gln Asn Ile Leu Lys Arg Val Glu Glu 
            420                 425                 430         


Arg Ser Glu Arg Glu Cys Thr Ala Leu Asp Ala His Lys Glu Leu Glu 
        435                 440                 445             


Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
    450                 455                 460                 


Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe Lys Ile Lys Ser 
465                 470                 475                 480 


Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln Gly Glu Leu 
                485                 490                 495     


Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg Thr Lys Lys 
            500                 505                 510         


Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu Leu Val Ile 
        515                 520                 525             


Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp Ser Ala Pro 
    530                 535                 540                 


Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly Gln Thr Leu 
545                 550                 555                 560 


Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp Asp Arg Glu 
                565                 570                 575     


Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met Lys Arg Trp 
            580                 585                 590         


Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe Val Ser Phe Thr 
        595                 600                 605             


Ser Arg Leu Leu Asp Cys Pro Gln Val Gln Cys Val His Pro Tyr Val 
    610                 615                 620                 


Ala Gln Gln Pro Asp Glu Leu Thr Leu Glu Leu Ala Asp Ile Leu Asn 
625                 630                 635                 640 


Ile Leu Asp Lys Thr Asp Asp Gly Trp Ile Phe Gly Glu Arg Leu His 
                645                 650                 655     


Asp Gln Glu Arg Gly Trp Phe Pro Ser Ser Met Thr Glu Glu Ile Leu 
            660                 665                 670         


Asn Pro Lys Ile Arg Ser Gln Asn Leu Lys Glu Cys Phe Arg Val His 
        675                 680                 685             


Lys Met Asp Asp Pro Gln Arg Ser Gln Asn Lys Asp Arg Arg Lys Leu 
    690                 695                 700                 


Gly Ser Arg Asn Arg Gln 
705                 710 


<210>  1539
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  1539
atggcgtccc ttcctgtcct gcagaaggag agcgtgttcc agtcgggagc ccatgcctac     60

agaatccctg ccctgctcta cctgcctggg cagcagtccc tgctggcctt cgcggaacag    120

cgggcaagca agaaggatga gcacgcagag ctgattgtcc tgcgcagagg agactacgac    180

gcacccaccc accaggttca gtggcaagct caggaggtgg tggcccaggc ccggctggat    240

ggccaccggt ccatgaaccc atgccccttg tatgacgcgc agacggggac cctcttcctc    300

ttcttcattg ccatccctgg gcaagtcacg gagcaacagc agctgcagac cagggccaat    360

gtgacgcggc tgtgccaagt caccagcact gaccacggga ggacctggag ctcccccaga    420

gacctcactg atgcggccat cggcccagcc taccgggagt ggtccacctt tgcagtgggc    480

ccggggcatt gtttgcagct taacgacagg gcccggagcc tggtggtgcc cgcctacgcc    540

taccggaaac ttcaccccat ccaaaggccg atcccctctg ccttctgctt cctcagccat    600

gaccatgggc gcacgtgggc gcgagggcac tttgtggccc aggacaccct ggagtgccag    660

gtggccgaag tcgagactgg ggagcagagg gtggtgaccc tcaacgcgag aagccacctc    720

cgagccaggg tccaggccca gagcaccaat gacgggcttg atttccagga gtctcagctg    780

gtgaagaagc tggtggagcc gccgccccag ggctgccagg ggagcgtcat cagcttcccc    840

agcccccgct cggggcctgg ctccccagcc cagtggctgc tctacactca ccccacacac    900

tcctggcaga gggccgacct gggtgcctac ctcaacccgc gacctccagc ccctgaggcc    960

tggtcagagc cggtactgct ggccaagggc agctgtgcct actcagacct ccagagcatg   1020

ggcaccggcc ctgatgggtc ccccttgttt gggtgtctgt acgaagccaa tgattacgag   1080

gagattgtct ttctcatgtt caccctgaag caagccttcc cagctgagta cctgcctcag   1140

tga                                                                 1143


<210>  1540
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  1540

Met Ala Ser Leu Pro Val Leu Gln Lys Glu Ser Val Phe Gln Ser Gly 
1               5                   10                  15      


Ala His Ala Tyr Arg Ile Pro Ala Leu Leu Tyr Leu Pro Gly Gln Gln 
            20                  25                  30          


Ser Leu Leu Ala Phe Ala Glu Gln Arg Ala Ser Lys Lys Asp Glu His 
        35                  40                  45              


Ala Glu Leu Ile Val Leu Arg Arg Gly Asp Tyr Asp Ala Pro Thr His 
    50                  55                  60                  


Gln Val Gln Trp Gln Ala Gln Glu Val Val Ala Gln Ala Arg Leu Asp 
65                  70                  75                  80  


Gly His Arg Ser Met Asn Pro Cys Pro Leu Tyr Asp Ala Gln Thr Gly 
                85                  90                  95      


Thr Leu Phe Leu Phe Phe Ile Ala Ile Pro Gly Gln Val Thr Glu Gln 
            100                 105                 110         


Gln Gln Leu Gln Thr Arg Ala Asn Val Thr Arg Leu Cys Gln Val Thr 
        115                 120                 125             


Ser Thr Asp His Gly Arg Thr Trp Ser Ser Pro Arg Asp Leu Thr Asp 
    130                 135                 140                 


Ala Ala Ile Gly Pro Ala Tyr Arg Glu Trp Ser Thr Phe Ala Val Gly 
145                 150                 155                 160 


Pro Gly His Cys Leu Gln Leu Asn Asp Arg Ala Arg Ser Leu Val Val 
                165                 170                 175     


Pro Ala Tyr Ala Tyr Arg Lys Leu His Pro Ile Gln Arg Pro Ile Pro 
            180                 185                 190         


Ser Ala Phe Cys Phe Leu Ser His Asp His Gly Arg Thr Trp Ala Arg 
        195                 200                 205             


Gly His Phe Val Ala Gln Asp Thr Leu Glu Cys Gln Val Ala Glu Val 
    210                 215                 220                 


Glu Thr Gly Glu Gln Arg Val Val Thr Leu Asn Ala Arg Ser His Leu 
225                 230                 235                 240 


Arg Ala Arg Val Gln Ala Gln Ser Thr Asn Asp Gly Leu Asp Phe Gln 
                245                 250                 255     


Glu Ser Gln Leu Val Lys Lys Leu Val Glu Pro Pro Pro Gln Gly Cys 
            260                 265                 270         


Gln Gly Ser Val Ile Ser Phe Pro Ser Pro Arg Ser Gly Pro Gly Ser 
        275                 280                 285             


Pro Ala Gln Trp Leu Leu Tyr Thr His Pro Thr His Ser Trp Gln Arg 
    290                 295                 300                 


Ala Asp Leu Gly Ala Tyr Leu Asn Pro Arg Pro Pro Ala Pro Glu Ala 
305                 310                 315                 320 


Trp Ser Glu Pro Val Leu Leu Ala Lys Gly Ser Cys Ala Tyr Ser Asp 
                325                 330                 335     


Leu Gln Ser Met Gly Thr Gly Pro Asp Gly Ser Pro Leu Phe Gly Cys 
            340                 345                 350         


Leu Tyr Glu Ala Asn Asp Tyr Glu Glu Ile Val Phe Leu Met Phe Thr 
        355                 360                 365             


Leu Lys Gln Ala Phe Pro Ala Glu Tyr Leu Pro Gln 
    370                 375                 380 


<210>  1541
<211>  4925
<212>  DNA
<213>  Homosapiens

<400>  1541
aaacaggaag tcagtcagtt aagctggtgg cagcagccga ggccaccaag aggcaacggg     60

cggcaggttg cagtggaggg gcctccgctc ccctcggtgg tgtgtgggtc ctgggggtgc    120

ctgccggccc ggccgaggag gcccacgccc accatggtcc cctgctggaa ccatggcaac    180

atcacccgct ccaaggcgga ggagctgctt tccaggacag gcaaggacgg gagcttcctc    240

gtgcgtgcca gcgagtccat ctcccgggca tacgcgctct gcgtgctgta tcggaattgc    300

gtttacactt acagaattct gcccaatgaa gatgataaat tcactgttca ggcatccgaa    360

ggcgtctcca tgaggttctt caccaagctg gaccagctca tcgagtttta caagaaggaa    420

aacatggggc tggtgaccca tctgcaatac cctgtgccgc tggaggaaga ggacacaggc    480

gacgaccctg aggaggacac agaaagtgtc gtgtctccac ccgagctgcc cccaagaaac    540

atcccgctga ctgccagctc ctgtgaggcc aaggaggttc ctttttcaaa cgagaatccc    600

cgagcgaccg agaccagccg gccgagcctc tccgagacat tgttccagcg actgcaaagc    660

atggacacca gtgggcttcc agaagagcat cttaaggcca tccaagatta tttaagcact    720

cagctcgccc aggactctga atttgtgaag acagggtcca gcagtcttcc tcacctgaag    780

aaactgacca cactgctctg caaggagctc tatggagaag tcatccggac cctcccatcc    840

ctggagtctc tgcagaggtt atttgaccag cagctctccc cgggcctccg tccacgtcct    900

caggttcctg gtgaggccaa tcccatcaac atggtgtcca agctcagcca actgacaagc    960

ctgttgtcat ccattgaaga caaggtcaag gccttgctgc acgagggtcc tgagtctccg   1020

caccggccct cccttatccc tccagtcacc tttgaggtga aggcagagtc tctggggatt   1080

cctcagaaaa tgcagctcaa agtcgacgtt gagtctggga aactgatcat taagaagtcc   1140

aaggatggtt ctgaggacaa gttctacagc cacaagaaaa tcctgcagct cattaagtca   1200

cagaaatttc tgaataagtt ggtgatcttg gtggaaacag agaaggagaa gatcctgcgg   1260

aaggaatatg tttttgctga ctccaaaaag agagaaggct tctgccagct cctgcagcag   1320

atgaagaaca agcactcaga gcagccggag cccgacatga tcaccatctt catcggcacc   1380

tggaacatgg gtaacgcccc ccctcccaag aagatcacgt cctggtttct ctccaagggg   1440

cagggaaaga cgcgggacga ctctgcggac tacatccccc atgacattta cgtgatcggc   1500

acccaagagg accccctgag tgagaaggag tggctggaga tcctcaaaca ctccctgcaa   1560

gaaatcacca gtgtgacttt taaaacagtc gccatccaca cgctctggaa catccgcatc   1620

gtggtgctgg ccaagcctga gcacgagaac cggatcagcc acatctgtac tgacaacgtg   1680

aagacaggca ttgcaaacac actggggaac aagggagccg tgggggtgtc gttcatgttc   1740

aatggaacct ccttagggtt cgtcaacagc cacttgactt caggaagtga aaagaaactc   1800

aggcgaaacc aaaactatat gaacattctc cggttcctgg ccctgggcga caagaagctg   1860

agtcccttta acatcactca ccgcttcacg cacctcttct ggtttgggga tcttaactac   1920

cgtgtggatc tgcctacctg ggaggcagaa accatcatcc agaaaatcaa gcagcagcag   1980

tacgcagacc tcctgtccca cgaccagctg ctcacagaga ggagggagca gaaggtcttc   2040

ctacacttcg aggaggaaga aatcacgttt gccccaacct accgttttga gagactgact   2100

cgggacaaat acgcctacac caagcagaaa gcgacaggga tgaagtacaa cttgccttcc   2160

tggtgtgacc gagtcctctg gaagtcttat cccctggtgc acgtggtgtg tcagtcttat   2220

ggcagtacca gcgacatcat gacgagtgac cacagccctg tctttgccac atttgaggca   2280

ggagtcactt cccagtttgt ctccaagaac ggtcccggga ctgttgacag ccaaggacag   2340

attgagtttc tcaggtgcta tgccacattg aagaccaagt cccagaccaa attctacctg   2400

gagttccact cgagctgctt ggagagtttt gtcaagagtc aggaaggaga aaatgaagaa   2460

ggaagtgagg gggagctggt ggtgaagttt ggtgagactc ttccaaagct gaagcccatt   2520

atctctgacc ctgagtacct gctagaccag cacatcctca tcagcatcaa gtcctctgac   2580

agcgacgaat cctatggcga gggctgcatt gcccttcggt tagaggccac agaaacgcag   2640

ctgcccatct acacgcctct cacccaccat ggggagttga caggccactt ccagggggag   2700

atcaagctgc agacctctca gggcaagacg agggagaagc tctatgactt tgtgaagacg   2760

gagcgtgatg aatccagtgg gccaaagacc ctgaagagcc tcaccagcca cgaccccatg   2820

aagcagtggg aagtcactag cagggcccct ccgtgcagtg gctccagcat cactgaaatc   2880

atcaacccca actacatggg agtggggccc tttgggccac caatgcccct gcacgtgaag   2940

cagaccttgt cccctgacca gcagcccaca gcctggagct acgaccagcc gcccaaggac   3000

tccccgctgg ggccctgcag gggagaaagt cctccgacac ctcccggcca gccgcccata   3060

tcacccaaga agtttttacc ctcaacagca aaccggggtc tccctcccag gacacaggag   3120

tcaaggccca gtgacctggg gaagaacgca ggggacacgc tgcctcagga ggacctgccg   3180

ctgacgaagc ccgagatgtt tgagaacccc ctgtatgggt ccctgagttc cttccctaag   3240

cctgctccca ggaaggacca ggaatccccc aaaatgccgc ggaaggaacc cccgccctgc   3300

ccggaacccg gcatcttgtc gcccagcatc gtgctcacca aagcccagga ggctgatcgc   3360

ggcgaggggc ccggcaagca ggtgcccgcg ccccggctgc gctccttcac gtgctcatcc   3420

tctgccgagg gcagggcggc cggcggggac aagagccaag ggaagcccaa gaccccggtc   3480

agctcccagg ccccggtgcc ggccaagagg cccatcaagc cttccagatc ggaaatcaac   3540

cagcagaccc cgcccacccc gacgccgcgg ccgccgctgc cagtcaagag cccggcggtg   3600

ctgcacctcc agcactccaa gggccgcgac taccgcgaca acaccgagct cccgcatcac   3660

ggcaagcacc ggccggagga ggggccacca gggcctctag gcaggactgc catgcagtga   3720

agccctcagt gagctgccac tgagtcggga gcccagagga acggcgtgaa gccactggac   3780

cctctcccgg gacctcctgc tggctcctcc tgcccagctt cctatgcaag gctttgtgtt   3840

ttcaggaaag ggcctagctt ctgtgtggcc cacagagttc actgcctgtg agacttagca   3900

ccaagtgctg aggctggaag aaaaacgcac accagacggg caacaaacag tctgggtccc   3960

cagctcgctc ttggtacttg ggaccccagt gcctcgttga gggcgccatt ctgaagaaag   4020

gaactgcagc gccgatttga gggtggagat atagataata ataatattaa taataataat   4080

ggccacatgg atcgaacact catgatgtgc caagtgctgt gctaagtgct ttacgaacat   4140

tcgtcatatc aggatgacct cgagagctga ggctctagcc acctaaaacc acgtgcccaa   4200

acccaccagt ttaaaacggt gtgtgttcgg aggggtgaaa gcattaagaa gcccagtgcc   4260

ctcctggagt gagacaaggg ctcggcctta aggagctgaa gagtctgggt agcttgttta   4320

gggtacaaga agcctgttct gtccagcttc agtgacacaa gctgctttag ctaaagtccc   4380

gcgggttccg gcatggctag gctgagagca gggatctacc tggcttctca gttctttggt   4440

tggaaggagc aggaaatcag ctcctattct ccagtggaga gatctggcct cagcttgggc   4500

tagagatgcc aaggcctgtg ccaggttccc tgtgccctcc tcgaggtggg cagccatcac   4560

cagccacagt taagccaagc cccccaacat gtattccatc gtgctggtag aagagtcttt   4620

gctgttgctc ccgaaagccg tgctctccag cctggctgcc agggagggtg ggcctcttgg   4680

ttccaggctc ttgaaatagt gcagcctttt cttcctatct ctgtggcttt cagctctgct   4740

tccttggtta ttaggagaat agatgggtga tgtctttcct tatgttgctt tttcaacata   4800

gcagaattaa tgtagggagc taaatccagt ggtgtgtgtg aatgcagaag ggaatgcacc   4860

ccacattccc atgatggaag tctgcgtaac caataaattg tgcctttctc actcaaaaaa   4920

aaaaa                                                               4925


<210>  1542
<211>  1188
<212>  PRT
<213>  Homosapiens

<400>  1542

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro Arg 
        115                 120                 125             


Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro Phe 
    130                 135                 140                 


Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu Ser 
145                 150                 155                 160 


Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu Pro 
                165                 170                 175     


Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu Ala 
            180                 185                 190         


Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His Leu 
        195                 200                 205             


Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val Ile 
    210                 215                 220                 


Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln Gln 
225                 230                 235                 240 


Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala Asn 
                245                 250                 255     


Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu Ser 
            260                 265                 270         


Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu Ser 
        275                 280                 285             


Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys Ala 
    290                 295                 300                 


Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val Glu 
305                 310                 315                 320 


Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp Lys 
                325                 330                 335     


Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys Phe 
            340                 345                 350         


Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile Leu 
        355                 360                 365             


Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe Cys 
    370                 375                 380                 


Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu Pro 
385                 390                 395                 400 


Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala Pro 
                405                 410                 415     


Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly Lys 
            420                 425                 430         


Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val Ile 
        435                 440                 445             


Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile Leu 
    450                 455                 460                 


Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val Ala 
465                 470                 475                 480 


Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro Glu 
                485                 490                 495     


His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr Gly 
            500                 505                 510         


Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe Met 
        515                 520                 525             


Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser Gly 
    530                 535                 540                 


Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu Arg 
545                 550                 555                 560 


Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr His 
                565                 570                 575     


Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val Asp 
            580                 585                 590         


Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln Gln 
        595                 600                 605             


Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg Arg 
    610                 615                 620                 


Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe Ala 
625                 630                 635                 640 


Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr Thr 
                645                 650                 655     


Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys Asp 
            660                 665                 670         


Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln Ser 
        675                 680                 685             


Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val Phe 
    690                 695                 700                 


Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn Gly 
705                 710                 715                 720 


Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys Tyr 
                725                 730                 735     


Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe His 
            740                 745                 750         


Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn Glu 
        755                 760                 765             


Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu Pro 
    770                 775                 780                 


Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln His 
785                 790                 795                 800 


Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly Glu 
                805                 810                 815     


Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro Ile 
            820                 825                 830         


Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln Gly 
        835                 840                 845             


Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu Tyr 
    850                 855                 860                 


Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr Leu 
865                 870                 875                 880 


Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr Ser 
                885                 890                 895     


Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn Pro 
            900                 905                 910         


Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His Val 
        915                 920                 925             


Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr Asp 
    930                 935                 940                 


Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser Pro 
945                 950                 955                 960 


Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu Pro 
                965                 970                 975     


Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg Pro 
            980                 985                 990         


Ser Asp Leu Gly Lys Asn Ala Gly  Asp Thr Leu Pro Gln  Glu Asp Leu 
        995                 1000                 1005             


Pro Leu  Thr Lys Pro Glu Met  Phe Glu Asn Pro Leu  Tyr Gly Ser 
    1010                 1015                 1020             


Leu Ser  Ser Phe Pro Lys Pro  Ala Pro Arg Lys Asp  Gln Glu Ser 
    1025                 1030                 1035             


Pro Lys  Met Pro Arg Lys Glu  Pro Pro Pro Cys Pro  Glu Pro Gly 
    1040                 1045                 1050             


Ile Leu  Ser Pro Ser Ile Val  Leu Thr Lys Ala Gln  Glu Ala Asp 
    1055                 1060                 1065             


Arg Gly  Glu Gly Pro Gly Lys  Gln Val Pro Ala Pro  Arg Leu Arg 
    1070                 1075                 1080             


Ser Phe  Thr Cys Ser Ser Ser  Ala Glu Gly Arg Ala  Ala Gly Gly 
    1085                 1090                 1095             


Asp Lys  Ser Gln Gly Lys Pro  Lys Thr Pro Val Ser  Ser Gln Ala 
    1100                 1105                 1110             


Pro Val  Pro Ala Lys Arg Pro  Ile Lys Pro Ser Arg  Ser Glu Ile 
    1115                 1120                 1125             


Asn Gln  Gln Thr Pro Pro Thr  Pro Thr Pro Arg Pro  Pro Leu Pro 
    1130                 1135                 1140             


Val Lys  Ser Pro Ala Val Leu  His Leu Gln His Ser  Lys Gly Arg 
    1145                 1150                 1155             


Asp Tyr  Arg Asp Asn Thr Glu  Leu Pro His His Gly  Lys His Arg 
    1160                 1165                 1170             


Pro Glu  Glu Gly Pro Pro Gly  Pro Leu Gly Arg Thr  Ala Met Gln 
    1175                 1180                 1185             


<210>  1543
<211>  4928
<212>  DNA
<213>  Homosapiens

<400>  1543
aaacaggaag tcagtcagtt aagctggtgg cagcagccga ggccaccaag aggcaacggg     60

cggcaggttg cagtggaggg gcctccgctc ccctcggtgg tgtgtgggtc ctgggggtgc    120

ctgccggccc ggccgaggag gcccacgccc accatggtcc cctgctggaa ccatggcaac    180

atcacccgct ccaaggcgga ggagctgctt tccaggacag gcaaggacgg gagcttcctc    240

gtgcgtgcca gcgagtccat ctcccgggca tacgcgctct gcgtgctgta tcggaattgc    300

gtttacactt acagaattct gcccaatgaa gatgataaat tcactgttca ggcatccgaa    360

ggcgtctcca tgaggttctt caccaagctg gaccagctca tcgagtttta caagaaggaa    420

aacatggggc tggtgaccca tctgcaatac cctgtgccgc tggaggaaga ggacacaggc    480

gacgaccctg aggaggacac agtagaaagt gtcgtgtctc cacccgagct gcccccaaga    540

aacatcccgc tgactgccag ctcctgtgag gccaaggagg ttcctttttc aaacgagaat    600

ccccgagcga ccgagaccag ccggccgagc ctctccgaga cattgttcca gcgactgcaa    660

agcatggaca ccagtgggct tccagaagag catcttaagg ccatccaaga ttatttaagc    720

actcagctcg cccaggactc tgaatttgtg aagacagggt ccagcagtct tcctcacctg    780

aagaaactga ccacactgct ctgcaaggag ctctatggag aagtcatccg gaccctccca    840

tccctggagt ctctgcagag gttatttgac cagcagctct ccccgggcct ccgtccacgt    900

cctcaggttc ctggtgaggc caatcccatc aacatggtgt ccaagctcag ccaactgaca    960

agcctgttgt catccattga agacaaggtc aaggccttgc tgcacgaggg tcctgagtct   1020

ccgcaccggc cctcccttat ccctccagtc acctttgagg tgaaggcaga gtctctgggg   1080

attcctcaga aaatgcagct caaagtcgac gttgagtctg ggaaactgat cattaagaag   1140

tccaaggatg gttctgagga caagttctac agccacaaga aaatcctgca gctcattaag   1200

tcacagaaat ttctgaataa gttggtgatc ttggtggaaa cagagaagga gaagatcctg   1260

cggaaggaat atgtttttgc tgactccaaa aagagagaag gcttctgcca gctcctgcag   1320

cagatgaaga acaagcactc agagcagccg gagcccgaca tgatcaccat cttcatcggc   1380

acctggaaca tgggtaacgc cccccctccc aagaagatca cgtcctggtt tctctccaag   1440

gggcagggaa agacgcggga cgactctgcg gactacatcc cccatgacat ttacgtgatc   1500

ggcacccaag aggaccccct gagtgagaag gagtggctgg agatcctcaa acactccctg   1560

caagaaatca ccagtgtgac ttttaaaaca gtcgccatcc acacgctctg gaacatccgc   1620

atcgtggtgc tggccaagcc tgagcacgag aaccggatca gccacatctg tactgacaac   1680

gtgaagacag gcattgcaaa cacactgggg aacaagggag ccgtgggggt gtcgttcatg   1740

ttcaatggaa cctccttagg gttcgtcaac agccacttga cttcaggaag tgaaaagaaa   1800

ctcaggcgaa accaaaacta tatgaacatt ctccggttcc tggccctggg cgacaagaag   1860

ctgagtccct ttaacatcac tcaccgcttc acgcacctct tctggtttgg ggatcttaac   1920

taccgtgtgg atctgcctac ctgggaggca gaaaccatca tccagaaaat caagcagcag   1980

cagtacgcag acctcctgtc ccacgaccag ctgctcacag agaggaggga gcagaaggtc   2040

ttcctacact tcgaggagga agaaatcacg tttgccccaa cctaccgttt tgagagactg   2100

actcgggaca aatacgccta caccaagcag aaagcgacag ggatgaagta caacttgcct   2160

tcctggtgtg accgagtcct ctggaagtct tatcccctgg tgcacgtggt gtgtcagtct   2220

tatggcagta ccagcgacat catgacgagt gaccacagcc ctgtctttgc cacatttgag   2280

gcaggagtca cttcccagtt tgtctccaag aacggtcccg ggactgttga cagccaagga   2340

cagattgagt ttctcaggtg ctatgccaca ttgaagacca agtcccagac caaattctac   2400

ctggagttcc actcgagctg cttggagagt tttgtcaaga gtcaggaagg agaaaatgaa   2460

gaaggaagtg agggggagct ggtggtgaag tttggtgaga ctcttccaaa gctgaagccc   2520

attatctctg accctgagta cctgctagac cagcacatcc tcatcagcat caagtcctct   2580

gacagcgacg aatcctatgg cgagggctgc attgcccttc ggttagaggc cacagaaacg   2640

cagctgccca tctacacgcc tctcacccac catggggagt tgacaggcca cttccagggg   2700

gagatcaagc tgcagacctc tcagggcaag acgagggaga agctctatga ctttgtgaag   2760

acggagcgtg atgaatccag tgggccaaag accctgaaga gcctcaccag ccacgacccc   2820

atgaagcagt gggaagtcac tagcagggcc cctccgtgca gtggctccag catcactgaa   2880

atcatcaacc ccaactacat gggagtgggg ccctttgggc caccaatgcc cctgcacgtg   2940

aagcagacct tgtcccctga ccagcagccc acagcctgga gctacgacca gccgcccaag   3000

gactccccgc tggggccctg caggggagaa agtcctccga cacctcccgg ccagccgccc   3060

atatcaccca agaagttttt accctcaaca gcaaaccggg gtctccctcc caggacacag   3120

gagtcaaggc ccagtgacct ggggaagaac gcaggggaca cgctgcctca ggaggacctg   3180

ccgctgacga agcccgagat gtttgagaac cccctgtatg ggtccctgag ttccttccct   3240

aagcctgctc ccaggaagga ccaggaatcc cccaaaatgc cgcggaagga acccccgccc   3300

tgcccggaac ccggcatctt gtcgcccagc atcgtgctca ccaaagccca ggaggctgat   3360

cgcggcgagg ggcccggcaa gcaggtgccc gcgccccggc tgcgctcctt cacgtgctca   3420

tcctctgccg agggcagggc ggccggcggg gacaagagcc aagggaagcc caagaccccg   3480

gtcagctccc aggccccggt gccggccaag aggcccatca agccttccag atcggaaatc   3540

aaccagcaga ccccgcccac cccgacgccg cggccgccgc tgccagtcaa gagcccggcg   3600

gtgctgcacc tccagcactc caagggccgc gactaccgcg acaacaccga gctcccgcat   3660

cacggcaagc accggccgga ggaggggcca ccagggcctc taggcaggac tgccatgcag   3720

tgaagccctc agtgagctgc cactgagtcg ggagcccaga ggaacggcgt gaagccactg   3780

gaccctctcc cgggacctcc tgctggctcc tcctgcccag cttcctatgc aaggctttgt   3840

gttttcagga aagggcctag cttctgtgtg gcccacagag ttcactgcct gtgagactta   3900

gcaccaagtg ctgaggctgg aagaaaaacg cacaccagac gggcaacaaa cagtctgggt   3960

ccccagctcg ctcttggtac ttgggacccc agtgcctcgt tgagggcgcc attctgaaga   4020

aaggaactgc agcgccgatt tgagggtgga gatatagata ataataatat taataataat   4080

aatggccaca tggatcgaac actcatgatg tgccaagtgc tgtgctaagt gctttacgaa   4140

cattcgtcat atcaggatga cctcgagagc tgaggctcta gccacctaaa accacgtgcc   4200

caaacccacc agtttaaaac ggtgtgtgtt cggaggggtg aaagcattaa gaagcccagt   4260

gccctcctgg agtgagacaa gggctcggcc ttaaggagct gaagagtctg ggtagcttgt   4320

ttagggtaca agaagcctgt tctgtccagc ttcagtgaca caagctgctt tagctaaagt   4380

cccgcgggtt ccggcatggc taggctgaga gcagggatct acctggcttc tcagttcttt   4440

ggttggaagg agcaggaaat cagctcctat tctccagtgg agagatctgg cctcagcttg   4500

ggctagagat gccaaggcct gtgccaggtt ccctgtgccc tcctcgaggt gggcagccat   4560

caccagccac agttaagcca agccccccaa catgtattcc atcgtgctgg tagaagagtc   4620

tttgctgttg ctcccgaaag ccgtgctctc cagcctggct gccagggagg gtgggcctct   4680

tggttccagg ctcttgaaat agtgcagcct tttcttccta tctctgtggc tttcagctct   4740

gcttccttgg ttattaggag aatagatggg tgatgtcttt ccttatgttg ctttttcaac   4800

atagcagaat taatgtaggg agctaaatcc agtggtgtgt gtgaatgcag aagggaatgc   4860

accccacatt cccatgatgg aagtctgcgt aaccaataaa ttgtgccttt ctcactcaaa   4920

aaaaaaaa                                                            4928


<210>  1544
<211>  1189
<212>  PRT
<213>  Homosapiens

<400>  1544

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Val Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro 
        115                 120                 125             


Arg Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro 
    130                 135                 140                 


Phe Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu 
145                 150                 155                 160 


Ser Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu 
                165                 170                 175     


Pro Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu 
            180                 185                 190         


Ala Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His 
        195                 200                 205             


Leu Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val 
    210                 215                 220                 


Ile Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln 
225                 230                 235                 240 


Gln Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala 
                245                 250                 255     


Asn Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu 
            260                 265                 270         


Ser Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu 
        275                 280                 285             


Ser Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys 
    290                 295                 300                 


Ala Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val 
305                 310                 315                 320 


Glu Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp 
                325                 330                 335     


Lys Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys 
            340                 345                 350         


Phe Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile 
        355                 360                 365             


Leu Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe 
    370                 375                 380                 


Cys Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu 
385                 390                 395                 400 


Pro Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala 
                405                 410                 415     


Pro Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly 
            420                 425                 430         


Lys Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val 
        435                 440                 445             


Ile Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile 
    450                 455                 460                 


Leu Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val 
465                 470                 475                 480 


Ala Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro 
                485                 490                 495     


Glu His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr 
            500                 505                 510         


Gly Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe 
        515                 520                 525             


Met Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser 
    530                 535                 540                 


Gly Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu 
545                 550                 555                 560 


Arg Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr 
                565                 570                 575     


His Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val 
            580                 585                 590         


Asp Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln 
        595                 600                 605             


Gln Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg 
    610                 615                 620                 


Arg Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe 
625                 630                 635                 640 


Ala Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr 
                645                 650                 655     


Thr Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys 
            660                 665                 670         


Asp Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln 
        675                 680                 685             


Ser Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val 
    690                 695                 700                 


Phe Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn 
705                 710                 715                 720 


Gly Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys 
                725                 730                 735     


Tyr Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe 
            740                 745                 750         


His Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn 
        755                 760                 765             


Glu Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu 
    770                 775                 780                 


Pro Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln 
785                 790                 795                 800 


His Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly 
                805                 810                 815     


Glu Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro 
            820                 825                 830         


Ile Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln 
        835                 840                 845             


Gly Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu 
    850                 855                 860                 


Tyr Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr 
865                 870                 875                 880 


Leu Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr 
                885                 890                 895     


Ser Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn 
            900                 905                 910         


Pro Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His 
        915                 920                 925             


Val Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr 
    930                 935                 940                 


Asp Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser 
945                 950                 955                 960 


Pro Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu 
                965                 970                 975     


Pro Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg 
            980                 985                 990         


Pro Ser Asp Leu Gly Lys Asn Ala  Gly Asp Thr Leu Pro  Gln Glu Asp 
        995                 1000                 1005             


Leu Pro  Leu Thr Lys Pro Glu  Met Phe Glu Asn Pro  Leu Tyr Gly 
    1010                 1015                 1020             


Ser Leu  Ser Ser Phe Pro Lys  Pro Ala Pro Arg Lys  Asp Gln Glu 
    1025                 1030                 1035             


Ser Pro  Lys Met Pro Arg Lys  Glu Pro Pro Pro Cys  Pro Glu Pro 
    1040                 1045                 1050             


Gly Ile  Leu Ser Pro Ser Ile  Val Leu Thr Lys Ala  Gln Glu Ala 
    1055                 1060                 1065             


Asp Arg  Gly Glu Gly Pro Gly  Lys Gln Val Pro Ala  Pro Arg Leu 
    1070                 1075                 1080             


Arg Ser  Phe Thr Cys Ser Ser  Ser Ala Glu Gly Arg  Ala Ala Gly 
    1085                 1090                 1095             


Gly Asp  Lys Ser Gln Gly Lys  Pro Lys Thr Pro Val  Ser Ser Gln 
    1100                 1105                 1110             


Ala Pro  Val Pro Ala Lys Arg  Pro Ile Lys Pro Ser  Arg Ser Glu 
    1115                 1120                 1125             


Ile Asn  Gln Gln Thr Pro Pro  Thr Pro Thr Pro Arg  Pro Pro Leu 
    1130                 1135                 1140             


Pro Val  Lys Ser Pro Ala Val  Leu His Leu Gln His  Ser Lys Gly 
    1145                 1150                 1155             


Arg Asp  Tyr Arg Asp Asn Thr  Glu Leu Pro His His  Gly Lys His 
    1160                 1165                 1170             


Arg Pro  Glu Glu Gly Pro Pro  Gly Pro Leu Gly Arg  Thr Ala Met 
    1175                 1180                 1185             


Gln 
    


<210>  1545
<211>  1557
<212>  DNA
<213>  Homosapiens

<400>  1545
ggcagcgcgc cggccgcgag agagggcccc gtcgcgaccg cgtccccttg ggtccttgat     60

cctgagctga ccgggtagcc atggccttgc ggctcctgaa gctggcagcg acgtccgcgt    120

ccgcccgggt cgtggcggcg ggcgcccagc gcgtgagagg aattcatagc agtgtgcagt    180

gcaaactgcg ctatggaatg tggcatttcc tacttgggga taaagcaagc aaaagactga    240

cagaacgcag cagagtgata actgtagatg gcaatatatg tactggaaaa ggcaaacttg    300

caaaagaaat agcagagaaa ctaggcttca agcactttcc tgaagcgggg attcattatc    360

cagacagtac cacaggagat gggaagcccc tcgccaccga ctataatggc aactgtagtt    420

tggagaaatt ttacgatgat ccgagaagca atgatggcaa cagttaccgc ctgcagtcct    480

ggttgtacag cagtcgcctg ctgcagtact cagatgcctt ggagcacttg ctgaccacag    540

gacaaggtgt tgtgttggag cgctccatct tcagtgactt tgtgttcctg gaggcgatgt    600

acaaccaggg attcatccga aagcagtgtg tggaccacta caacgaggtg aagagcgtca    660

ccatctgcga ttacctgccc ccccacctgg tgatttacat cgatgtgccc gttccagagg    720

tccagaggcg gattcagaag aaaggagatc cacatgaaat gaagatcacc tctgcctatc    780

tacaggacat tgagaatgcc tataagaaaa cctttctccc tgagatgagt gaaaaatgtg    840

aggttttaca atattctgca agggaagctc aagattcaaa aaaggtggta gaggacattg    900

aatacctgaa gttcgataaa gggccgtggc tcaagcagga caatcgcact ttataccacc    960

tgcgattact ggttcaggat aagtttgagg tgctgaatta cacaagcatt cctatctttc   1020

tcccggaagt caccattgga gctcatcaga ctgaccgtgt cttacatcag ttcagagagc   1080

tgccgggccg caagtacagc cctgggtaca acaccgaggt gggagacaag tggatctggc   1140

tgaagtgaac gggccgcctt ctgctccagc tgcatcacag tgatggccaa gctgcatcag   1200

ccgcactctc ctggacgcca tatagcttta agatcggggg agggtaaata atgcaaaaat   1260

tgcacagtgg aagaaggggt ctcacaaaaa gcaatccatc ctgtagtata ggtaatggag   1320

ttgggggaag cagcttccat tctggatgtt tggaaccctt tagctttgtt ttggaatggc   1380

ccaccattct cactggaaaa cagtggtctg ctgtgaaagg ccagctctcg gcagcccctg   1440

tggtttcagc gctgccgctc tgtgtcattc aggttgtgca cattgttttt cttctgactt   1500

ccagaaataa aagtgtttcc atgggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      1557


<210>  1546
<211>  355
<212>  PRT
<213>  Homosapiens

<400>  1546

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Cys Val Asp His Tyr Asn Glu Val Lys Ser 
            180                 185                 190         


Val Thr Ile Cys Asp Tyr Leu Pro Pro His Leu Val Ile Tyr Ile Asp 
        195                 200                 205             


Val Pro Val Pro Glu Val Gln Arg Arg Ile Gln Lys Lys Gly Asp Pro 
    210                 215                 220                 


His Glu Met Lys Ile Thr Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala 
225                 230                 235                 240 


Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu 
                245                 250                 255     


Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp 
            260                 265                 270         


Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn 
        275                 280                 285             


Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val 
    290                 295                 300                 


Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly 
305                 310                 315                 320 


Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Leu Pro Gly 
                325                 330                 335     


Arg Lys Tyr Ser Pro Gly Tyr Asn Thr Glu Val Gly Asp Lys Trp Ile 
            340                 345                 350         


Trp Leu Lys 
        355 


<210>  1547
<211>  996
<212>  DNA
<213>  Homosapiens

<400>  1547
atgagtgggg agaatgtcac cagggtcggc accttcatcc tggtgggctt ccccacggcc     60

ccagggctgc agtacctgct cttcctcctc ttcctgctca cctacctctt tgtcctggtg    120

gagaacctgg ccatcatcct caccgtctgg agcagcacct ccctccacag gcccatgtac    180

tactttctga gctccatgtc tttcctagag atctggtacg tgtctgacat cacccccaag    240

atgctggagg gcttcctcct ccagcagaaa cgcatctctt tcgtcgggtg catgacgcag    300

ctctacttct tcagctccct ggtgtgcacc gagtgtgtgc ttctggcctc catggcctac    360

gaccgctacg tggccatctg ccacccgctg cgctaccacg tccttgtgac cccggggctg    420

tgcctccagc tggtgggctt ctcctttgtg agtggcttca ccatctccat gatcaaggtc    480

tgttttatct ccagcgtcac gttctgtggc tccaacgtct tgaaccactt cttctgtgac    540

atttccccca tcctcaagct ggcctgcacg gacttctcca ctgcagagct ggtggatttc    600

attctggcct tcatcatcct ggtgtttcca ctcctggcca ccatgctgtc atatgcgcac    660

atcaccctgg ctgtcctgcg catcccctcg gccaccggct gctggagagc cttcttcacc    720

tgcgcctctc acctcaccgt ggtcaccgtc ttctatacag ccttgctttt catgtatgtc    780

cggccccagg ccattgattc ccggagctcc aacaagctca tctctgtttt gtacacagtt    840

atcaccccca tcttgaaccc cttgatatac tgcctgagga ataaggaatt taagaatgcc    900

ttgaaaaaag ccttcggctt gacgagctgc gccgtagagg ggaggctttc tagtcttctg    960

gaacttcatc tccaaataca cagccagcct ctctga                              996


<210>  1548
<211>  331
<212>  PRT
<213>  Homosapiens

<400>  1548

Met Ser Gly Glu Asn Val Thr Arg Val Gly Thr Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Pro Thr Ala Pro Gly Leu Gln Tyr Leu Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Thr Tyr Leu Phe Val Leu Val Glu Asn Leu Ala Ile Ile Leu Thr 
        35                  40                  45              


Val Trp Ser Ser Thr Ser Leu His Arg Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Ser Met Ser Phe Leu Glu Ile Trp Tyr Val Ser Asp Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Glu Gly Phe Leu Leu Gln Gln Lys Arg Ile Ser Phe Val Gly 
                85                  90                  95      


Cys Met Thr Gln Leu Tyr Phe Phe Ser Ser Leu Val Cys Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr His Val Leu Val Thr Pro Gly Leu Cys Leu Gln Leu 
    130                 135                 140                 


Val Gly Phe Ser Phe Val Ser Gly Phe Thr Ile Ser Met Ile Lys Val 
145                 150                 155                 160 


Cys Phe Ile Ser Ser Val Thr Phe Cys Gly Ser Asn Val Leu Asn His 
                165                 170                 175     


Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Thr Asp Phe 
            180                 185                 190         


Ser Thr Ala Glu Leu Val Asp Phe Ile Leu Ala Phe Ile Ile Leu Val 
        195                 200                 205             


Phe Pro Leu Leu Ala Thr Met Leu Ser Tyr Ala His Ile Thr Leu Ala 
    210                 215                 220                 


Val Leu Arg Ile Pro Ser Ala Thr Gly Cys Trp Arg Ala Phe Phe Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Thr Val Phe Tyr Thr Ala Leu Leu 
                245                 250                 255     


Phe Met Tyr Val Arg Pro Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys 
            260                 265                 270         


Leu Ile Ser Val Leu Tyr Thr Val Ile Thr Pro Ile Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Cys Leu Arg Asn Lys Glu Phe Lys Asn Ala Leu Lys Lys Ala 
    290                 295                 300                 


Phe Gly Leu Thr Ser Cys Ala Val Glu Gly Arg Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Glu Leu His Leu Gln Ile His Ser Gln Pro Leu 
                325                 330     


<210>  1549
<211>  759
<212>  DNA
<213>  Homosapiens

<400>  1549
atgtggcgcg cgccggaagc ggctctgagg ccggaagtga gcctagagcg ccgcggcccc     60

gagatgaagc cggcggtgga cgagatgttc cccgagggcg ccgggcccta cgtggacctg    120

gacgaggtgg cacgggcccg gcgggagtct ccgagcgcgg gaggcagcac cgggctcttg    180

atggacttgg cagccaatga aaaggccgtt catgcagact tttttaacga ttttgaagat    240

ctttttgatg atgatgacat ccacagctca ggactgccca ggacaagcca gcagtcctcc    300

atggttcccg cactgcagcg agggcagtcg gagcacgggg tccgtgggaa ggcagcagag    360

cggcctgtgg tgtcggaaga gagatgtgaa ctgaacggga gagaagtggc agctttggac    420

agagcgtttg ggagcacagg ccatgggcag ggggcggagg cgctaatgtt taccagatgc    480

agagaacatc cgctgtgtgg caccaacaaa gcaacaagtg aggggaaaat gggcacagga    540

cgcttaagaa acagtttacg gaagaaccaa tccaagtggc tgggaagtta tctagaggtg    600

ctcagaacca caagaagcag gcgagaggtc agcgaagaca gcacaatatc agtttctact    660

cactggaggg gtaaatgttt taagagtgat gaaacaccat ccgttgctgg tggagaagaa    720

gggaagaaga ccacacagcc atgcatagat gtgaggtag                           759


<210>  1550
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  1550

Met Trp Arg Ala Pro Glu Ala Ala Leu Arg Pro Glu Val Ser Leu Glu 
1               5                   10                  15      


Arg Arg Gly Pro Glu Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu 
            20                  25                  30          


Gly Ala Gly Pro Tyr Val Asp Leu Asp Glu Val Ala Arg Ala Arg Arg 
        35                  40                  45              


Glu Ser Pro Ser Ala Gly Gly Ser Thr Gly Leu Leu Met Asp Leu Ala 
    50                  55                  60                  


Ala Asn Glu Lys Ala Val His Ala Asp Phe Phe Asn Asp Phe Glu Asp 
65                  70                  75                  80  


Leu Phe Asp Asp Asp Asp Ile His Ser Ser Gly Leu Pro Arg Thr Ser 
                85                  90                  95      


Gln Gln Ser Ser Met Val Pro Ala Leu Gln Arg Gly Gln Ser Glu His 
            100                 105                 110         


Gly Val Arg Gly Lys Ala Ala Glu Arg Pro Val Val Ser Glu Glu Arg 
        115                 120                 125             


Cys Glu Leu Asn Gly Arg Glu Val Ala Ala Leu Asp Arg Ala Phe Gly 
    130                 135                 140                 


Ser Thr Gly His Gly Gln Gly Ala Glu Ala Leu Met Phe Thr Arg Cys 
145                 150                 155                 160 


Arg Glu His Pro Leu Cys Gly Thr Asn Lys Ala Thr Ser Glu Gly Lys 
                165                 170                 175     


Met Gly Thr Gly Arg Leu Arg Asn Ser Leu Arg Lys Asn Gln Ser Lys 
            180                 185                 190         


Trp Leu Gly Ser Tyr Leu Glu Val Leu Arg Thr Thr Arg Ser Arg Arg 
        195                 200                 205             


Glu Val Ser Glu Asp Ser Thr Ile Ser Val Ser Thr His Trp Arg Gly 
    210                 215                 220                 


Lys Cys Phe Lys Ser Asp Glu Thr Pro Ser Val Ala Gly Gly Glu Glu 
225                 230                 235                 240 


Gly Lys Lys Thr Thr Gln Pro Cys Ile Asp Val Arg 
                245                 250         


<210>  1551
<211>  4021
<212>  DNA
<213>  Homosapiens

<400>  1551
ggtcgcccct ccccggattc ccccaccctc cgtgcctgca ggagcccctg ggctttcccg     60

gaggagctcg ccctgaaggg cccggacctc ggcgagccca ccaccgttcc ctccagcgcc    120

gccgccgcca ccgcagcagc cggagcagca tggtccagct gaggaagctg ctccgcgtcc    180

tgactttgat gaagttcccc tgctgcgtgc tggaggtgct cctgtgcgcg ctggcggcgg    240

cggcgcgcgg ccaggagatg tacgccccgc actcaatccg gatcgagggg gacgtcaccc    300

tcggggggct gttccccgtg cacgccaagg gtcccagcgg agtgccctgc ggcgacatca    360

agagggaaaa cgggatccac aggctggaag cgatgctcta cgccctggac cagatcaaca    420

gtgatcccaa cctactgccc aacgtgacgc tgggcgcgcg gatcctggac acttgttcca    480

gggacactta cgcgctcgaa cagtcgctta ctttcgtcca ggcgctcatc cagaaggaca    540

cctccgacgt gcgctgcacc aacggcgaac cgccggtttt cgtcaagccg gagaaagtag    600

ttggagtgat tggggcttcg gggagttcgg tctccatcat ggtagccaac atcctgaggc    660

tcttccagat cccccagatt agttatgcat caacggcacc cgagctaagt gatgaccggc    720

gctatgactt cttctctcgc gtggtgccac ccgattcctt ccaagcccag gccatggtag    780

acattgtaaa ggccctaggc tggaattatg tgtctaccct cgcatcggaa ggaagttatg    840

gagagaaagg tgtggagtcc ttcacgcaga tttccaaaga ggcaggtgga ctctgcattg    900

cccagtccgt gagaatcccc caggaacgca aagacaggac cattgacttt gatagaatta    960

tcaaacagct cctggacacc cccaactcca gggccgtcgt gatttttgcc aacgatgagg   1020

atataaagca gatccttgca gcagccaaaa gagctgacca agttggccat tttctttggg   1080

tgggatcaga cagctgggga tccaaaataa acccactgca ccagcatgaa gatatcgcag   1140

aaggggccat caccattcag cccaagcgag ccacggtgga agggtttgat gcctacttta   1200

cgtcccgtac acttgaaaac aacagaagaa atgtatggtt tgccgaatac tgggaggaaa   1260

acttcaactg caagttgacg attagtgggt caaaaaaaga agacacagat cgcaaatgca   1320

caggacagga gagaattgga aaagattcca actatgagca ggagggtaaa gtccagttcg   1380

tgattgacgc agtctatgct atggctcacg cccttcacca catgaacaag gatctctgtg   1440

ctgactaccg gggtgtctgc ccagagatgg agcaagctgg aggcaagaag ttgctgaagt   1500

atatacgcaa tgttaatttc aatggtagtg ctggcactcc agtgatgttt aacaagaacg   1560

gggatgcacc tgggcgttat gacatctttc agtaccagac cacaaacacc agcaacccgg   1620

gttaccgtct gatcgggcag tggacagacg aacttcagct caatatagaa gacatgcagt   1680

ggggtaaagg agtccgagag atacccgcct cagtgtgcac actaccatgt aagccaggac   1740

agagaaagaa gacacagaaa ggaactcctt gctgttggac ctgtgagcct tgcgatggtt   1800

accagtacca gtttgatgag atgacatgcc agcattgccc ctatgaccag aggcccaatg   1860

aaaatcgaac cggatgccag gatattccca tcatcaaact ggagtggcac tccccctggg   1920

ctgtgattcc tgtcttcctg gcaatgttgg ggatcattgc caccatcttt gtcatggcca   1980

ctttcatccg ctacaatgac acgcccattg tccgggcatc tgggcgggaa ctcagctatg   2040

ttcttttgac gggcatcttt ctttgctaca tcatcacttt cctgatgatt gccaaaccag   2100

atgtggcagt gtgttctttc cggcgagttt tcttgggctt gggtatgtgc atcagttatg   2160

cagccctctt gacgaaaaca aatcggattt atcgcatatt tgagcagggc aagaaatcag   2220

taacagctcc cagactcata agcccaacat cacaactggc aatcacttcc agtttaatat   2280

cagttcagct tctaggggtg ttcatttggt ttggtgttga tccacccaac atcatcatag   2340

actatgatga acacaagaca atgaaccctg agcaagccag aggggttctc aagtgtgaca   2400

ttacagatct ccaaatcatt tgctccttgg gatatagcat tcttctcatg gtcacatgta   2460

ctgtgtatgc catcaagact cggggtgtac ccgagaattt taacgaagcc aagcccattg   2520

gattcactat gtacacgaca tgtatagtat ggcttgcctt cattccaatt ttttttggca   2580

ccgctcaatc agcggaaaag ctctacatac aaactaccac gcttacaatc tccatgaacc   2640

taagtgcatc agtggcgctg gggatgctat acatgccgaa agtgtacatc atcattttcc   2700

accctgaact caatgtccag aaacggaagc gaagcttcaa ggcggtagtc acagcagcca   2760

ccatgtcatc gaggctgtca cacaaaccca gtgacagacc caacggtgag gcaaagaccg   2820

agctctgtga aaacgtagac ccaaacagcc ctgctgcaaa aaagaagtat gtcagttata   2880

ataacctggt tatctaacct gttccattcc atggaaccat ggaggaggaa gaccctcagt   2940

tattttgtca cccaacctgg cataggactc tttggtccta cccgcttccc atcaccggag   3000

gagcttcccc ggccgggaga ccagtgttag aggatccaag cgacctaaac agctgcttta   3060

tgaaatatcc ttactttatc tgggcttaat aagtcactga catcagcact gccaactcgg   3120

ctgcaattgt ggaccttccc taccaaaggg agtgttgaaa ctcaagtccc gccctggctc   3180

tttagaatgg accactgaga gccacaggac cgttttgggg ctgacctgtc ttattacgta   3240

tgtacttcta ggttgcaagg ttttgaaatt ttctgtacag tttgtgagga cctttgcact   3300

ttgccatctg atgtcgtacc tcggttcact gtttgttttc gaatgccttg ttttcataga   3360

gccctattct ctcagacggt ggaatatttg gaaaaatttt aaaacaatta aaattttaaa   3420

gcaatcttgg cagactaaaa caagtacatc tgtacatgac tgtataatta cgattatagt   3480

accactgcac atcatgtttt tttttttaag acaaaaaaga tgtttaaaga ccaaaaactg   3540

tgctgagaaa gtatgcccca cctatctttg gtatatgata ggttacataa aaggaaggta   3600

ttggctgaac tgaatagagg tcttgatctt tggaatgcat gccagtaatg tattttacag   3660

tacatgttta ttatgttcaa tatttgtatt tgtgttctct tttgttattt ttaattaggg   3720

tatatgaata ttttgcaata attttaataa ttattaagct gtttgaagga aagaatatgg   3780

atttttcatg tcttgaggtt ttgttcatgc cccctttgac tgatcagtgt gataaggact   3840

ttaggaaaaa aagcatgtat gttttttact gtttgtaata agtactttcg ttaatcttgc   3900

tgcttatgtg ccaatttagt ggaaaaaaac aacccttgct gaaaaattcc ctctttccat   3960

tctctttcaa ttctgtgata ttgtccaaga atgtatcaat aaaatacttt ggttaacttt   4020

t                                                                   4021


<210>  1552
<211>  915
<212>  PRT
<213>  Homosapiens

<400>  1552

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn 
            900                 905                 910         


Leu Val Ile 
        915 


<210>  1553
<211>  4113
<212>  DNA
<213>  Homosapiens

<400>  1553
ggtcgcccct ccccggattc ccccaccctc cgtgcctgca ggagcccctg ggctttcccg     60

gaggagctcg ccctgaaggg cccggacctc ggcgagccca ccaccgttcc ctccagcgcc    120

gccgccgcca ccgcagcagc cggagcagca tggtccagct gaggaagctg ctccgcgtcc    180

tgactttgat gaagttcccc tgctgcgtgc tggaggtgct cctgtgcgcg ctggcggcgg    240

cggcgcgcgg ccaggagatg tacgccccgc actcaatccg gatcgagggg gacgtcaccc    300

tcggggggct gttccccgtg cacgccaagg gtcccagcgg agtgccctgc ggcgacatca    360

agagggaaaa cgggatccac aggctggaag cgatgctcta cgccctggac cagatcaaca    420

gtgatcccaa cctactgccc aacgtgacgc tgggcgcgcg gatcctggac acttgttcca    480

gggacactta cgcgctcgaa cagtcgctta ctttcgtcca ggcgctcatc cagaaggaca    540

cctccgacgt gcgctgcacc aacggcgaac cgccggtttt cgtcaagccg gagaaagtag    600

ttggagtgat tggggcttcg gggagttcgg tctccatcat ggtagccaac atcctgaggc    660

tcttccagat cccccagatt agttatgcat caacggcacc cgagctaagt gatgaccggc    720

gctatgactt cttctctcgc gtggtgccac ccgattcctt ccaagcccag gccatggtag    780

acattgtaaa ggccctaggc tggaattatg tgtctaccct cgcatcggaa ggaagttatg    840

gagagaaagg tgtggagtcc ttcacgcaga tttccaaaga ggcaggtgga ctctgcattg    900

cccagtccgt gagaatcccc caggaacgca aagacaggac cattgacttt gatagaatta    960

tcaaacagct cctggacacc cccaactcca gggccgtcgt gatttttgcc aacgatgagg   1020

atataaagca gatccttgca gcagccaaaa gagctgacca agttggccat tttctttggg   1080

tgggatcaga cagctgggga tccaaaataa acccactgca ccagcatgaa gatatcgcag   1140

aaggggccat caccattcag cccaagcgag ccacggtgga agggtttgat gcctacttta   1200

cgtcccgtac acttgaaaac aacagaagaa atgtatggtt tgccgaatac tgggaggaaa   1260

acttcaactg caagttgacg attagtgggt caaaaaaaga agacacagat cgcaaatgca   1320

caggacagga gagaattgga aaagattcca actatgagca ggagggtaaa gtccagttcg   1380

tgattgacgc agtctatgct atggctcacg cccttcacca catgaacaag gatctctgtg   1440

ctgactaccg gggtgtctgc ccagagatgg agcaagctgg aggcaagaag ttgctgaagt   1500

atatacgcaa tgttaatttc aatggtagtg ctggcactcc agtgatgttt aacaagaacg   1560

gggatgcacc tgggcgttat gacatctttc agtaccagac cacaaacacc agcaacccgg   1620

gttaccgtct gatcgggcag tggacagacg aacttcagct caatatagaa gacatgcagt   1680

ggggtaaagg agtccgagag atacccgcct cagtgtgcac actaccatgt aagccaggac   1740

agagaaagaa gacacagaaa ggaactcctt gctgttggac ctgtgagcct tgcgatggtt   1800

accagtacca gtttgatgag atgacatgcc agcattgccc ctatgaccag aggcccaatg   1860

aaaatcgaac cggatgccag gatattccca tcatcaaact ggagtggcac tccccctggg   1920

ctgtgattcc tgtcttcctg gcaatgttgg ggatcattgc caccatcttt gtcatggcca   1980

ctttcatccg ctacaatgac acgcccattg tccgggcatc tgggcgggaa ctcagctatg   2040

ttcttttgac gggcatcttt ctttgctaca tcatcacttt cctgatgatt gccaaaccag   2100

atgtggcagt gtgttctttc cggcgagttt tcttgggctt gggtatgtgc atcagttatg   2160

cagccctctt gacgaaaaca aatcggattt atcgcatatt tgagcagggc aagaaatcag   2220

taacagctcc cagactcata agcccaacat cacaactggc aatcacttcc agtttaatat   2280

cagttcagct tctaggggtg ttcatttggt ttggtgttga tccacccaac atcatcatag   2340

actatgatga acacaagaca atgaaccctg agcaagccag aggggttctc aagtgtgaca   2400

ttacagatct ccaaatcatt tgctccttgg gatatagcat tcttctcatg gtcacatgta   2460

ctgtgtatgc catcaagact cggggtgtac ccgagaattt taacgaagcc aagcccattg   2520

gattcactat gtacacgaca tgtatagtat ggcttgcctt cattccaatt ttttttggca   2580

ccgctcaatc agcggaaaag ctctacatac aaactaccac gcttacaatc tccatgaacc   2640

taagtgcatc agtggcgctg gggatgctat acatgccgaa agtgtacatc atcattttcc   2700

accctgaact caatgtccag aaacggaagc gaagcttcaa ggcggtagtc acagcagcca   2760

ccatgtcatc gaggctgtca cacaaaccca gtgacagacc caacggtgag gcaaagaccg   2820

agctctgtga aaacgtagac ccaaacaact gtataccacc agtaagaaag agtgtacaaa   2880

agtctgttac ttggtacact atcccaccaa cagtatagct tttgactgct ttcccaaagg   2940

ccctgctgca aaaaagaagt atgtcagtta taataacctg gttatctaac ctgttccatt   3000

ccatggaacc atggaggagg aagaccctca gttattttgt cacccaacct ggcataggac   3060

tctttggtcc tacccgcttc ccatcaccgg aggagcttcc ccggccggga gaccagtgtt   3120

agaggatcca agcgacctaa acagctgctt tatgaaatat ccttacttta tctgggctta   3180

ataagtcact gacatcagca ctgccaactc ggctgcaatt gtggaccttc cctaccaaag   3240

ggagtgttga aactcaagtc ccgccctggc tctttagaat ggaccactga gagccacagg   3300

accgttttgg ggctgacctg tcttattacg tatgtacttc taggttgcaa ggttttgaaa   3360

ttttctgtac agtttgtgag gacctttgca ctttgccatc tgatgtcgta cctcggttca   3420

ctgtttgttt tcgaatgcct tgttttcata gagccctatt ctctcagacg gtggaatatt   3480

tggaaaaatt ttaaaacaat taaaatttta aagcaatctt ggcagactaa aacaagtaca   3540

tctgtacatg actgtataat tacgattata gtaccactgc acatcatgtt ttttttttta   3600

agacaaaaaa gatgtttaaa gaccaaaaac tgtgctgaga aagtatgccc cacctatctt   3660

tggtatatga taggttacat aaaaggaagg tattggctga actgaataga ggtcttgatc   3720

tttggaatgc atgccagtaa tgtattttac agtacatgtt tattatgttc aatatttgta   3780

tttgtgttct cttttgttat ttttaattag ggtatatgaa tattttgcaa taattttaat   3840

aattattaag ctgtttgaag gaaagaatat ggatttttca tgtcttgagg ttttgttcat   3900

gccccctttg actgatcagt gtgataagga ctttaggaaa aaaagcatgt atgtttttta   3960

ctgtttgtaa taagtacttt cgttaatctt gctgcttatg tgccaattta gtggaaaaaa   4020

acaacccttg ctgaaaaatt ccctctttcc attctctttc aattctgtga tattgtccaa   4080

gaatgtatca ataaaatact ttggttaact ttt                                4113


<210>  1554
<211>  922
<212>  PRT
<213>  Homosapiens

<400>  1554

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Asn Cys Ile Pro Pro Val Arg Lys Ser Val Gln Lys Ser 
            900                 905                 910         


Val Thr Trp Tyr Thr Ile Pro Pro Thr Val 
        915                 920         


<210>  1555
<211>  3185
<212>  DNA
<213>  Homosapiens

<400>  1555
ggtcgcccct ccccggattc ccccaccctc cgtgcctgca ggagcccctg ggctttcccg     60

gaggagctcg ccctgaaggg cccggacctc ggcgagccca ccaccgttcc ctccagcgcc    120

gccgccgcca ccgcagcagc cggagcagca tggtccagct gaggaagctg ctccgcgtcc    180

tgactttgat gaagttcccc tgctgcgtgc tggaggtgct cctgtgcgcg ctggcggcgg    240

cggcgcgcgg ccaggagatg tacgccccgc actcaatccg gatcgagggg gacgtcaccc    300

tcggggggct gttccccgtg cacgccaagg gtcccagcgg agtgccctgc ggcgacatca    360

agagggaaaa cgggatccac aggctggaag cgatgctcta cgccctggac cagatcaaca    420

gtgatcccaa cctactgccc aacgtgacgc tgggcgcgcg gatcctggac acttgttcca    480

gggacactta cgcgctcgaa cagtcgctta ctttcgtcca ggcgctcatc cagaaggaca    540

cctccgacgt gcgctgcacc aacggcgaac cgccggtttt cgtcaagccg gagaaagtag    600

ttggagtgat tggggcttcg gggagttcgg tctccatcat ggtagccaac atcctgaggc    660

tcttccagat cccccagatt agttatgcat caacggcacc cgagctaagt gatgaccggc    720

gctatgactt cttctctcgc gtggtgccac ccgattcctt ccaagcccag gccatggtag    780

acattgtaaa ggccctaggc tggaattatg tgtctaccct cgcatcggaa ggaagttatg    840

gagagaaagg tgtggagtcc ttcacgcaga tttccaaaga ggcaggtgga ctctgcattg    900

cccagtccgt gagaatcccc caggaacgca aagacaggac cattgacttt gatagaatta    960

tcaaacagct cctggacacc cccaactcca gggccgtcgt gatttttgcc aacgatgagg   1020

atataaagca gatccttgca gcagccaaaa gagctgacca agttggccat tttctttggg   1080

tgggatcaga cagctgggga tccaaaataa acccactgca ccagcatgaa gatatcgcag   1140

aaggggccat caccattcag cccaagcgag ccacggtgga agggtttgat gcctacttta   1200

cgtcccgtac acttgaaaac aacagaagaa atgtatggtt tgccgaatac tgggaggaaa   1260

acttcaactg caagttgacg attagtgggt caaaaaaaga agacacagat cgcaaatgca   1320

caggacagga gagaattgga aaagattcca actatgagca ggagggtaaa gtccagttcg   1380

tgattgacgc agtctatgct atggctcacg cccttcacca catgaacaag gatctctgtg   1440

ctgactaccg gggtgtctgc ccagagatgg agcaagctgg aggcaagaag ttgctgaagt   1500

atatacgcaa tgttaatttc aatggtagtg ctggcactcc agtgatgttt aacaagaacg   1560

gggatgcacc tgggcgttat gacatctttc agtaccagac cacaaacacc agcaacccgg   1620

gttaccgtct gatcgggcag tggacagacg aacttcagct caatatagaa gacatgcagt   1680

ggggtaaagg agtccgagag atacccgcct cagtgtgcac actaccatgt aagccaggac   1740

agagaaagaa gacacagaaa ggaactcctt gctgttggac ctgtgagcct tgcgatggtt   1800

accagtacca gtttgatgag atgacatgcc agcattgccc ctatgaccag aggcccaatg   1860

aaaatcgaac cggatgccag gatattccca tcatcaaact ggagtggcac tccccctggg   1920

ctgtgattcc tgtcttcctg gcaatgttgg ggatcattgc caccatcttt gtcatggcca   1980

ctttcatccg ctacaatgac acgcccattg tccgggcatc tgggcgggaa ctcagctatg   2040

ttcttttgac gggcatcttt ctttgctaca tcatcacttt cctgatgatt gccaaaccag   2100

atgtggcagt gtgttctttc cggcgagttt tcttgggctt gggtatgtgc atcagttatg   2160

cagccctctt gacgaaaaca aatcggattt atcgcatatt tgagcagggc aagaaatcag   2220

taacagctcc cagactcata agcccaacat cacaactggc aatcacttcc agtttaatat   2280

cagttcagct tctaggggtg ttcatttggt ttggtgttga tccacccaac atcatcatag   2340

actatgatga acacaagaca atgaaccctg agcaagccag aggggttctc aagtgtgaca   2400

ttacagatct ccaaatcatt tgctccttgg gatatagcat tcttctcatg gtcacatgta   2460

ctgtgtatgc catcaagact cggggtgtac ccgagaattt taacgaagcc aagcccattg   2520

gattcactat gtacacgaca tgtatagtat ggcttgcctt cattccaatt ttttttggca   2580

ccgctcaatc agcggaaaag ctctacatac aaactaccac gcttacaatc tccatgaacc   2640

taagtgcatc agtggcgctg gggatgctat acatgccgaa agtgtacatc atcattttcc   2700

accctgaact caatgtccag aaacggaagc gaagcttcaa ggcggtagtc acagcagcca   2760

ccatgtcatc gaggctgtca cacaaaccca gtgacagacc caacggtgag gcaaagaccg   2820

agctctgtga aaacgtagac ccaaacaatt tttttttttg gctgtacagt ggaacttgga   2880

ttacacttta aattaacttt ctctaggaat caaagtaacc tctgaggacc tcagcttgca   2940

caaagaggat tgagataaca tttccaaagc ttgttcttct tgagctgacc caacacttag   3000

gaaaacatga catggatcag caactccatt ttctgtgaga agtgcaactg ctactgacca   3060

tctgcactgg catctagtca agcgattgtc tgaggaaagg attttggaga ttcccatctg   3120

atattcttct atttggtctc ttgtacccat tgtcatcctg taccacacat aataaagttt   3180

aagaa                                                               3185


<210>  1556
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  1556

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Asn Phe Phe Phe Trp Leu Tyr Ser Gly Thr Trp Ile Thr 
            900                 905                 910         


Leu 
    


<210>  1557
<211>  621
<212>  DNA
<213>  Homosapiens

<400>  1557
atggcttctg ccattggctc tctcccccag caccctgcca cgacagaaaa aagcaatccg     60

attccagaaa atccggaggc aaatggaggc gcctggtcct ggttagttcc caggttgatg    120

gaaggctttg atgtctgcac tgataagctg aagccggatc aaaaagtcct taagaaagct    180

gggcttgcct actcgcttca gcagctccag ggctctggaa atacctggaa gctgctccct    240

gcaggccact ctgtatcagg ctctttgctt atgctagggc atgaagcctc atccaaagcc    300

ccgaattaca gcacaacttt gaaagtgata gagtcaaaca cttacaggac aaatacacca    360

aggggatgga agggaagaaa taaaggaatc caggacctgg aggagagctt tgtgactgtt    420

gctgcagtcc tgggtcatca gagaaagctg cagaagtact ccagtgattg tgagagcatc    480

agaagaactg gccatggtgg gttgccaagt gatcagaagc tggaggagtt aaaggcaggg    540

gagccagata accagcaaca aagtagtgca gaggggcgag agttatttga cagcagcggg    600

aacttcctgt acagaatttg a                                              621


<210>  1558
<211>  206
<212>  PRT
<213>  Homosapiens

<400>  1558

Met Ala Ser Ala Ile Gly Ser Leu Pro Gln His Pro Ala Thr Thr Glu 
1               5                   10                  15      


Lys Ser Asn Pro Ile Pro Glu Asn Pro Glu Ala Asn Gly Gly Ala Trp 
            20                  25                  30          


Ser Trp Leu Val Pro Arg Leu Met Glu Gly Phe Asp Val Cys Thr Asp 
        35                  40                  45              


Lys Leu Lys Pro Asp Gln Lys Val Leu Lys Lys Ala Gly Leu Ala Tyr 
    50                  55                  60                  


Ser Leu Gln Gln Leu Gln Gly Ser Gly Asn Thr Trp Lys Leu Leu Pro 
65                  70                  75                  80  


Ala Gly His Ser Val Ser Gly Ser Leu Leu Met Leu Gly His Glu Ala 
                85                  90                  95      


Ser Ser Lys Ala Pro Asn Tyr Ser Thr Thr Leu Lys Val Ile Glu Ser 
            100                 105                 110         


Asn Thr Tyr Arg Thr Asn Thr Pro Arg Gly Trp Lys Gly Arg Asn Lys 
        115                 120                 125             


Gly Ile Gln Asp Leu Glu Glu Ser Phe Val Thr Val Ala Ala Val Leu 
    130                 135                 140                 


Gly His Gln Arg Lys Leu Gln Lys Tyr Ser Ser Asp Cys Glu Ser Ile 
145                 150                 155                 160 


Arg Arg Thr Gly His Gly Gly Leu Pro Ser Asp Gln Lys Leu Glu Glu 
                165                 170                 175     


Leu Lys Ala Gly Glu Pro Asp Asn Gln Gln Gln Ser Ser Ala Glu Gly 
            180                 185                 190         


Arg Glu Leu Phe Asp Ser Ser Gly Asn Phe Leu Tyr Arg Ile 
        195                 200                 205     


<210>  1559
<211>  2463
<212>  DNA
<213>  Homosapiens

<400>  1559
ctctttccct ccctcctctc ctctccctct cctctcctgc tatagagggc tccgacagca     60

gttcccagcc agcgtgttca gcctgcctgc ctgcctgcct ctgtgtgtgt gtgagcgtgt    120

gtgcgtgcgt ctactttgta ctgggaagaa cacagcccat gtgctctgca tggacgttac    180

tgatactctg tttagcttga ttttcgaaaa gcaggcaaga tgtccagcac accacatgac    240

cccttctatt cttctccttt cggcccattt tataggaggc atacaccata catggtacag    300

ccagagtacc gaatctatga gatgaacaag agactgcagt ctcgcacaga ggatagtgac    360

aacctctggt gggacgcctt tgccactgaa ttttttgaag atgacgccac attaaccctt    420

tcattttgtt tggaagatgg accaaagcga tacactatcg gcaggaccct catcccccgt    480

tactttagca ctgtgtttga aggaggggtg accgacctgt attacattct caaacactcg    540

aaagagtcat accacaactc atccatcacg gtggactgcg accagtgtac catggtcacc    600

cagcacggga agcccatgtt taccaaggta tgtacagaag gcagactgat cttggagttc    660

acctttgatg atctcatgag aatcaaaaca tggcacttta ccattagaca ataccgagag    720

ttagtcccga gaagcatcct agccatgcat gcacaagatc ctcaggtcct ggatcagctg    780

tccaaaaaca tcaccaggat ggggctaaca aacttcaccc tcaactacct caggttgtgt    840

gtaatattgg agccaatgca ggaactgatg tcgagacata aaacttacaa cctcagtccc    900

cgagactgcc tgaagacctg cttgtttcag aagtggcaga ggatggtggc tccgccagca    960

gaacccacaa ggcaaccaac aaccaaacgg agaaaaagga aaaattccac cagcagcact   1020

tccaacagca gcgctgggaa caatgcaaac agcactggca gcaagaagaa gaccacagct   1080

gcaaacctga gtctgtccag tcaggtacct gatgtgatgg tggtaggaga gccaactctg   1140

atgggaggtg agtttgggga cgaggacgaa aggctaatca ctagattaga aaacacgcaa   1200

tatgatgcgg ccaacggcat ggacgacgag gaggacttca acaattcacc cgcgctgggg   1260

aacaacagcc cgtggaacag taaacctccc gccactcaag agaccaaatc agaaaacccc   1320

ccaccccagg cttcccaata agatgatcgg caccagaatc cactgtcaat aggcccgtgg   1380

gtgatcatta caattgcaaa tctttactta caggagagga aacagaagag ataaaaactt   1440

ttccatgcaa atatctattt ctaaaccaca atgatctgat tttctttctt ctttcttttt   1500

ttctaattga gaggattatt cccagtaagc ttccatgacc ctttcttgga ggccttcaca   1560

ggtaatacag atactggcac tgattgtaat taaaatgaga gaaaactcta gcgcatcttc   1620

tggcacggtt ttaacaacgt gtttgtgttg aatttccttt ttatgcatca aacgaaggcc   1680

atattgtcca taaatgctca gtgctcagga tctcattaat atgccgaacc taactacaga   1740

tgacttttta atattgtaaa atattttctg ctttttgact tgcatctgag agtttcttgt   1800

ttcagtaaaa aaagaaaaga caaaaaaatc agctttggaa agtaatttaa atgtacctta   1860

tttttttttt ctttatgttt tctttcattg ggcaacagct aagagggccc agcaaggtaa   1920

tttatggttg agctgatgtc aattggttct tgtcttgagt cgactcaatt tagcccaagt   1980

gctgaaacaa gaaatgtcat ttttttcatc aaagacacca gggcagattt ttaagtaaag   2040

aaagacaatt ggacccttaa gaatttatgc atttgtaaag ttgctgttga tccaaatatt   2100

ttcaagccat gtaatccatt ggttttgtgg gcagtttaat aaacctgaac ctttgtgtgt   2160

tttctaattg tacctgagtt gaccatcctt tctttttata gtatatttct tgtatgatat   2220

tttgtaaagc tctcacctgg ttcttttatg gggacttttc gtttttgggc aactccagtg   2280

tatttatgtg aaactttata agagaattaa tttttccatt tgcatattaa tatgttcctc   2340

cacacatgta aaggcacagt ggctccgtgt gttaaaaaac agctgtattt tatgtatgct   2400

ttactgataa gtgtgccaat aataaactgt gttaatgacc aaaaaaaaaa aaaaaaaaaa   2460

aaa                                                                 2463


<210>  1560
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  1560

Met Ser Ser Thr Pro His Asp Pro Phe Tyr Ser Ser Pro Phe Gly Pro 
1               5                   10                  15      


Phe Tyr Arg Arg His Thr Pro Tyr Met Val Gln Pro Glu Tyr Arg Ile 
            20                  25                  30          


Tyr Glu Met Asn Lys Arg Leu Gln Ser Arg Thr Glu Asp Ser Asp Asn 
        35                  40                  45              


Leu Trp Trp Asp Ala Phe Ala Thr Glu Phe Phe Glu Asp Asp Ala Thr 
    50                  55                  60                  


Leu Thr Leu Ser Phe Cys Leu Glu Asp Gly Pro Lys Arg Tyr Thr Ile 
65                  70                  75                  80  


Gly Arg Thr Leu Ile Pro Arg Tyr Phe Ser Thr Val Phe Glu Gly Gly 
                85                  90                  95      


Val Thr Asp Leu Tyr Tyr Ile Leu Lys His Ser Lys Glu Ser Tyr His 
            100                 105                 110         


Asn Ser Ser Ile Thr Val Asp Cys Asp Gln Cys Thr Met Val Thr Gln 
        115                 120                 125             


His Gly Lys Pro Met Phe Thr Lys Val Cys Thr Glu Gly Arg Leu Ile 
    130                 135                 140                 


Leu Glu Phe Thr Phe Asp Asp Leu Met Arg Ile Lys Thr Trp His Phe 
145                 150                 155                 160 


Thr Ile Arg Gln Tyr Arg Glu Leu Val Pro Arg Ser Ile Leu Ala Met 
                165                 170                 175     


His Ala Gln Asp Pro Gln Val Leu Asp Gln Leu Ser Lys Asn Ile Thr 
            180                 185                 190         


Arg Met Gly Leu Thr Asn Phe Thr Leu Asn Tyr Leu Arg Leu Cys Val 
        195                 200                 205             


Ile Leu Glu Pro Met Gln Glu Leu Met Ser Arg His Lys Thr Tyr Asn 
    210                 215                 220                 


Leu Ser Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln Lys Trp Gln 
225                 230                 235                 240 


Arg Met Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Pro Thr Thr Lys 
                245                 250                 255     


Arg Arg Lys Arg Lys Asn Ser Thr Ser Ser Thr Ser Asn Ser Ser Ala 
            260                 265                 270         


Gly Asn Asn Ala Asn Ser Thr Gly Ser Lys Lys Lys Thr Thr Ala Ala 
        275                 280                 285             


Asn Leu Ser Leu Ser Ser Gln Val Pro Asp Val Met Val Val Gly Glu 
    290                 295                 300                 


Pro Thr Leu Met Gly Gly Glu Phe Gly Asp Glu Asp Glu Arg Leu Ile 
305                 310                 315                 320 


Thr Arg Leu Glu Asn Thr Gln Tyr Asp Ala Ala Asn Gly Met Asp Asp 
                325                 330                 335     


Glu Glu Asp Phe Asn Asn Ser Pro Ala Leu Gly Asn Asn Ser Pro Trp 
            340                 345                 350         


Asn Ser Lys Pro Pro Ala Thr Gln Glu Thr Lys Ser Glu Asn Pro Pro 
        355                 360                 365             


Pro Gln Ala Ser Gln 
    370             


<210>  1561
<211>  525
<212>  DNA
<213>  Homosapiens

<400>  1561
atgccgggcg accctccacc taccaagctc tatcatttca ggtcaacttc agactgctgt     60

gctggcagtg agaatttcaa gccaatggtt cttaggtttc tgggatgtgt gggagtggga    120

cccactaagc gagaccactt ggctccctgg cttcagcccc ctttccaggg gagtgaacgg    180

ttccatctca ctggggttcc aggtgccact gggaggaaga aacttaaggc ccaacaaatt    240

tatgcattga gccaaggaca agaaagaaat agcagaacaa gatctaaaag acaaattcct    300

tcgacttcag aattcatgac ttttctacta gcccaggtta cattttgttt aactgccaaa    360

tcacagtgca tttgatgtca cagatgttgt gctctcattt tgcagccttc tgtcctcagg    420

aagactcagg cagcatgttc ctctgttatt gaacgtacac aatattgtaa ttaattgttt    480

acctatctgg cactcccaat aaactgtact tcttatgcat aagaa                    525


<210>  1562
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  1562

Met Pro Gly Asp Pro Pro Pro Thr Lys Leu Tyr His Phe Arg Ser Thr 
1               5                   10                  15      


Ser Asp Cys Cys Ala Gly Ser Glu Asn Phe Lys Pro Met Val Leu Arg 
            20                  25                  30          


Phe Leu Gly Cys Val Gly Val Gly Pro Thr Lys Arg Asp His Leu Ala 
        35                  40                  45              


Pro Trp Leu Gln Pro Pro Phe Gln Gly Ser Glu Arg Phe His Leu Thr 
    50                  55                  60                  


Gly Val Pro Gly Ala Thr Gly Arg Lys Lys Leu Lys Ala Gln Gln Ile 
65                  70                  75                  80  


Tyr Ala Leu Ser Gln Gly Gln Glu Arg Asn Ser Arg Thr Arg Ser Lys 
                85                  90                  95      


Arg Gln Ile Pro Ser Thr Ser Glu Phe Met Thr Phe Leu Leu Ala Gln 
            100                 105                 110         


Val Thr Phe Cys Leu Thr Ala Lys Ser Gln Cys Ile 
        115                 120                 


<210>  1563
<211>  2310
<212>  DNA
<213>  Homosapiens

<400>  1563
gcttcaatgc cacggcctga ccggagtatc cgccatggag tcgcagaaag aggcacgaac     60

actccaggag cccgttgcgc ggccttctgg ggcctcaagc tctcagacgc cgaacgacaa    120

ggagcggcgg gagggcggcg cagtgccggc ggcggctgcc ctgggcgcag aggcggacga    180

cgacagtgcg gacgggctgt gggagctgcc ggtggagccg gccgagcgga ggcctgagtg    240

cacccgctgc agccggcctc agaaagtgtg tttgtgtcca tttctcccag cgcaccctct    300

gcatatctct acccacttgt acataattca gcatccagca gaggaaaaca aagtgttgcg    360

tacagttcct ctactagcag catgcctccc ccaggacaag tgtaaagtga agatcggtcg    420

tcgcttcagt gaagaaagag atcctgaact ttcaactgtt tgccggaagt ctggtacatt    480

aatattatat ccaggggctg aagctgctaa tttggaagaa tttatattag attctcctgt    540

ttatccttct acaatcatca tcattgatgg tacatggagc caggctaagg acattttcta    600

taagaactcc ttgttccgac atcccaaaca ggtgcaatta aaaactagca tttctagtca    660

gtatgtaatt cggatgcagc cgactaatag atgcctttct acactggagt gtgcagctgt    720

tgctctttcc atcttggaga aaaataatta catacaagag actttgcttc gccctcttca    780

agctttatgc tcctttcaac ttcagcatgg tgcccaaatt cgcctcagca aggaacacct    840

tctgaaaaat ggattatatc ctaaaccaat gccaaagaac aaacgcaaac tcaggaaaat    900

ggaattgtta atgaatagtg ttaaaattta gtacagttat tcttttggtg ctagcttaac    960

tgtcttcatc taacaatacc aaattaagtt ttcatatagt taaggtctgt aggtttttga   1020

cttgctaaag aagaatgaga attgcatact aatcttaccc agaagaagga agtaaaccaa   1080

atattcataa atacaaataa acagaaattc actggctcac tgaaaagcag gatttcctac   1140

tgtacttgtt tttaaaaatg tgcctctaat acatgttttc aaacccaaat ttaaaatatg   1200

atttgttgtt gtgataggtt agaagttctt acttgtaaaa tagaagaaaa ttgttgtagt   1260

ggattggaac ggtgttgtgt ccattaatgt ttataaataa ttaggtgtag accaataata   1320

taagattcct acatcagttt gcagtcctga ctttacagtt tgaaataagt agcaaaagaa   1380

aattatgata atcaagtaat ttattatttt gtaaaatagt ataaaggaat aaggaaattt   1440

taagtattgt ttaggggcca aatttgaact cagctaatat gatttaagcg ctctattaat   1500

tgccctgatt tttaaagagg tgcatgtaat tttgaaatag cacacatttt catttgtaat   1560

cactctggat aaatttgtat ttttcagtgt tcattgaaca ggcttattga ctctggtaaa   1620

cttattttat tgatgttttc atatggaaaa taataagtgg aatatgatac aattgttatt   1680

ttcagaacat atttctttag ggctatttaa tataaccttt ttaacgagca aaaactttcc   1740

atttgagaga aaaaattctt cctgctctgt gggaaaatat ttgctgagat tttgtataga   1800

ataagagaca tgtatgtaac atatatgtat attcagcaca agtctactgc aattatgtac   1860

acattttggc aagaagaggg gattttgttt agtctttgtt tatgacttct agagtttcct   1920

gtatctagtg ttaagttgta aggaaaaact aaacatgcca tttaaaggta aacttggtaa   1980

ctatttatag agcatacacc aatgattatt tctcacagtt ttcatgatca tttgtttatt   2040

atttacttgg attagactca ttaaaaggta taatgctggt cacaattaga atgctaatat   2100

ttggggaaac tatgcagaaa atattttaaa atattaaaag agtgctggct tctattgttg   2160

atttattttt ggatttaaaa acaaattagg gctgggccca ttagctcaca cctgtaatcc   2220

cagcactttg ggaggctgag atgtgagaat tgcttgagcc caggagtttg agaccagcct   2280

gggcaatatg gtgagactcc atctccatac                                    2310


<210>  1564
<211>  298
<212>  PRT
<213>  Homosapiens

<400>  1564

Met Glu Ser Gln Lys Glu Ala Arg Thr Leu Gln Glu Pro Val Ala Arg 
1               5                   10                  15      


Pro Ser Gly Ala Ser Ser Ser Gln Thr Pro Asn Asp Lys Glu Arg Arg 
            20                  25                  30          


Glu Gly Gly Ala Val Pro Ala Ala Ala Ala Leu Gly Ala Glu Ala Asp 
        35                  40                  45              


Asp Asp Ser Ala Asp Gly Leu Trp Glu Leu Pro Val Glu Pro Ala Glu 
    50                  55                  60                  


Arg Arg Pro Glu Cys Thr Arg Cys Ser Arg Pro Gln Lys Val Cys Leu 
65                  70                  75                  80  


Cys Pro Phe Leu Pro Ala His Pro Leu His Ile Ser Thr His Leu Tyr 
                85                  90                  95      


Ile Ile Gln His Pro Ala Glu Glu Asn Lys Val Leu Arg Thr Val Pro 
            100                 105                 110         


Leu Leu Ala Ala Cys Leu Pro Gln Asp Lys Cys Lys Val Lys Ile Gly 
        115                 120                 125             


Arg Arg Phe Ser Glu Glu Arg Asp Pro Glu Leu Ser Thr Val Cys Arg 
    130                 135                 140                 


Lys Ser Gly Thr Leu Ile Leu Tyr Pro Gly Ala Glu Ala Ala Asn Leu 
145                 150                 155                 160 


Glu Glu Phe Ile Leu Asp Ser Pro Val Tyr Pro Ser Thr Ile Ile Ile 
                165                 170                 175     


Ile Asp Gly Thr Trp Ser Gln Ala Lys Asp Ile Phe Tyr Lys Asn Ser 
            180                 185                 190         


Leu Phe Arg His Pro Lys Gln Val Gln Leu Lys Thr Ser Ile Ser Ser 
        195                 200                 205             


Gln Tyr Val Ile Arg Met Gln Pro Thr Asn Arg Cys Leu Ser Thr Leu 
    210                 215                 220                 


Glu Cys Ala Ala Val Ala Leu Ser Ile Leu Glu Lys Asn Asn Tyr Ile 
225                 230                 235                 240 


Gln Glu Thr Leu Leu Arg Pro Leu Gln Ala Leu Cys Ser Phe Gln Leu 
                245                 250                 255     


Gln His Gly Ala Gln Ile Arg Leu Ser Lys Glu His Leu Leu Lys Asn 
            260                 265                 270         


Gly Leu Tyr Pro Lys Pro Met Pro Lys Asn Lys Arg Lys Leu Arg Lys 
        275                 280                 285             


Met Glu Leu Leu Met Asn Ser Val Lys Ile 
    290                 295             


<210>  1565
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1565
gagggaagga gggagggaag cagccgctga cccgtggcat gagctggatg cggtgtccgt     60

tgcaggacta gggcgccgac atgaacctgc accaggtgct gaccggggct gtgaaccctg    120

gcgaccactg cttctccgtg ggcagcattg gcgaccagcg cttcacggct tatgcatctg    180

gatgtgacat tgtaatactg ggaagcgatt ttgaaagatt acagataatc ccaggagcta    240

aacatggaaa tattcaagtg ggatgtgtag actgttcaat gcaacaaggc aagattgcag    300

cgtcttatgg aaatgttatc tccatttttg aaccagttaa cctaccaaaa caaaagaaaa    360

atttggaatt atatagtcag tggcagaaaa gtggccaatt ttttctggaa tcaatagcac    420

acaatataac ctgggatccc acaggcagtc gtcttttaac tggttccagc tatttgcaac    480

tctggtccaa tactaacttg gagaagccaa ctgaagatga aaatttaaat aaaacagatc    540

ttaactttgg agattggaaa tgcatttggc attgcaaaac tgcttcccaa gttcatttaa    600

tgaaattttc accagatgga gaattttttg ccactgctgg gaaggatgac tgtcttttga    660

aggtttggta taatgtagaa aactggcgga cagctgttac ttctccagat ggaagttcag    720

aaaaacaatc ccaaggagaa attgactttt cttttgtgta tctggcccat cctcgagcag    780

taaatggatt ttcctggcgt aaaacaagca aatatatgcc tagggcttct gtatgtaatg    840

tactgttgac ttgctgcaaa gataatgtgt gtcgtctttg ggtagagaca tttttaccaa    900

atgattgttt gctatacgga ggtgactgca gccattggac tgaatcaatt aatttaacaa    960

ataacttcaa gagaaatgct tccagtaaag aacgagttca aaatgcttta gaagtaaatc   1020

tgagacattt tcgtagaggt cggaggagat cacttgctct tgtagcacat acgggatatc   1080

taccacatca gcaggatcct catcatgttc acaggaacac tccactgcat gccaatgcac   1140

tttgccactt tcatattgca gccagcatca acccagccac agacattcca cttcttccat   1200

ctattacatc tctgagtcta aatgaaaatg aagagaagac cggacctttt gttgtacact   1260

ggctaaacaa taaagaactg cattttactt tgtccatgga agttttttta cagcaactta   1320

gaaaaagttt tgaacaacca tcttctgagg ccagtgtaga agattctaat caggcagatg   1380

taaaatctga tgaagaaact gatgatggtg ttgatgatct gaaaataaat cccgaaaaga   1440

aggaattagg ctgtgataaa atggtaccaa actcaagttt tacatcatta tcgtcagctg   1500

ccattgatca tcagattgaa gtacttctgt ctgaatggag taaaaatgca gatatgctat   1560

ttagtattca tcccatggat ggttctttgc tagtttggca tgtggattgg ctggatgaat   1620

accagcctgg tatgtttcgt caagtacagg tgtcctttgt ttccagaatt ccagtagctt   1680

tccccacagg tgatgcaaac tctctctgta aaagcataat gatgtatgcc tgtaccaaga   1740

atgttgactt ggctattcag caggggaaac aaaaaccttc tggcctcacc cgttccacat   1800

caatgcttat ttcttctggt cacaataaat catctaatag tttaaaatta agtattttta   1860

cgcctaatgt tatgatgata tcaaaacatg ctgatggttc tctgaatcag tggctggtca   1920

gttttgccga ggaatctgct ttttctactg ttctcagtat ttcccacaaa tccagatatt   1980

gtggtcatcg ttttcatctt aatgatttag cttgccactc agtattacca ttattgctga   2040

caacatcaca ccataatgca ttaaggacac cagatgttga taacccagag caaccttttg   2100

atgctctaaa tattgaagaa tgctctttga cacaacaaaa taaaagcact gttgacgtgg   2160

catttcagga tcccagtgca gtttacagtg agcttattct gtggagggtt gacccagttg   2220

ggccattgtc tttttctgga ggagtttctg agcttgcccg gattaattct cttcatgttt   2280

ctgccttttc caatgtggca tggctgccca ctcttatacc cagttattgt ctgggtgcat   2340

actgcaactc tcctagtgca tgctttgtag ccagtgatgg acaatatctg agattatatg   2400

aagcagttat tgatgctaag aaacttttat ctgagctttc taaccctgaa atttctaaat   2460

atgttggtga agtctttaac atcgtcagtc aacaatcaac agccaggcca ggatgcatta   2520

ttgcattaga tcccattacc aaacttcatg gcagaaaaac ccaactgctt catgtttttg   2580

aagaagactt cattttgaat aaccttgaga agaaaagcct tggcaaagac agcattttat   2640

ctaatgcagg cagctcacct aatggatttt ctgagaagtt ctacctaatt gtaatagaat   2700

gcactcaaga caaccgttca ctgttacaca tgtggaattt acatctaaag tcaattcctg   2760

tctcattaga tgaaaaagta gatacaaaat tatccgaagc ggtttggcag ccagaagaac   2820

attattcttc ttctccagag aagatcctat ctcctttttc acaaaagtat caggcttgca   2880

gagcaaatct ccagagtacc agcaggttga ctctgttttc agaaatggtt tatagccaag   2940

aattgcattt accagaagga gttgagataa taagtattaa gccatcagca ggacatctga   3000

gttcatcttc tatatatcct gcatgcagtg ctccttattt attggcaact tcatgttcag   3060

atgagaaagt aagattctgg agatgcagag taacagatgg agaatctgcc acgtcaaaga   3120

atggaaaaat tgatcttgca tacatttggg aagaatggcc attacttatt gaagatggac   3180

ttcagagcaa tagtagtata actgtacctg gtaggcctgt agaagttagc tgtgcacata   3240

caaatcgttt agcagtagct tataagcagc ctgcatctaa tagtagatct tcccaggact   3300

ttgtgatgca tgtaagtatt tttgaatgtg agtcaacagg aggttcatgt tgggtccttg   3360

agcagacaat tcatttagat gagttaagca cagtattgga ttctggcatt agtgttgata   3420

gcaatttagt ggcctataat aaacaagaca tgtatttatc tagtaaagag aatatcacat   3480

caaacacaaa gcatttagtt cacttagatt ggatgtctag agaagacggt tctcatatcc   3540

tgactgtagg aattggatca aaacttttta tgtatggacc cctggctggc aaggtacaag   3600

accaaactgg taaggaaacc ctggcatttc ctctctggga gagtaccaaa gttgtgcccc   3660

tttctaaatt tgtactatta cgaagtgtgg acctagtttc ttctgtagat ggctccccac   3720

cttttcctgt ttctttatcg tgggtccggg atggcatcct tgtggtagga atggactgtg   3780

aaatgcatgt gtattgccaa tggcaaccat cttctaaaca agaacctgtt ataacagatt   3840

cgtacagtgg gagcactcca tctataacaa gtttaataaa acagagtaac tccagttctg   3900

ggttacatcc tccaaagaaa actctgactc gatccatgac cagtcttgca cagaaaatct   3960

gtggaaagaa aactgcattc gatccttcag tggatatgga agattcaggt ctttttgaag   4020

cagctcatgt actttccccg actctacctc agtatcatcc cttgcagctt ttggaactca   4080

tggatcttgg taaagttcgg agagccaagg ccatcttgtc ccatcttgtt aagtgcattg   4140

ctggggaagt tgtggctctg aatgaagctg aatctaatca tgaacgccgc cttaggtctc   4200

tcacaatcag tgctagtgga agcactacca gagaccccca ggcattcaac aaggctgaaa   4260

atacagatta cacagaaata gattctgttc ctccacttcc tttatatgcc ttacttgcag   4320

cagatgatga tagctgttac tcatctttgg agaaatctag taatgagagt acgttaagta   4380

aatcaaacca attatctaaa gaaagttatg atgagctttt tcagactcaa cttctaatga   4440

ctgatactca tatgttagag acagatgaag aaaatacaaa gcctagagtt attgaccttt   4500

cacagtacag tccgacttac tttggacctg agcatgctca ggttctttct ggccacttac   4560

ttcattctag tttaccagga ctcagccgga tggagcagat gtctttgatg gccttagcag   4620

atacaattgc aactacaagc actgatattg gagaaagccg agacagaagc caaggtggag   4680

aaactcttga tgaatgtggg ttaaaatttc ttttggctgt tcgactccat acctttctta   4740

caacttccct tccagcctat cgagctcaac tccttcacca aggcctgtct acaagtcatt   4800

ttgcttgggc atttcactca gtagcagaag aagaactgct gaacatgttg ccagccatgc   4860

agaaagatga tcccacttgg tctgaactaa gagctatggg tgtggggtgg tgggtccgga   4920

atacccgcat cttacgcaaa tgcatagaaa aagtagctaa agcagccttt tatagaaaga   4980

atgatccttt agatgctgcc attttttacc ttgcaatgaa aaagaaagct gtgatttggg   5040

gattatatag agctgaaaaa aacaccagga tgacacagtt ttttggacac aattttgagg   5100

atgagaggtg gcgtaaagca gctttaaaga atgctttttc tttgctaggc aaacaaagat   5160

ttgaacattc tgcagcattt tttcttttag ctggttgcct cagagatgca attgaggtat   5220

gtcttgagaa attgaatgac attcagttgg ctcttgtaat agcaagactc tatgagtctg   5280

aatttgatac atctgcagca tataaatcta ttttacgtaa aaaagttttg ggaatcgatt   5340

ctcctgtcag tgaactgtgt tcattgaaca taaatatgca tcatgatcct tttcttcgga   5400

gcatggcata ttggattttg gaagattata gtggtgctct ggaaacatta ataaagcaac   5460

ctatcagaga gaatgatgat caagttttat cagccagtaa tcctacagtt tttaatttct   5520

acaattatct aagaacacat cctcttttgc tgagacgtca ttttggatca tctgatacat   5580

tttccacaca tatgagccta acaggaaaaa gtggactggc aggaacaatt aatttaagtg   5640

aaagacgttt attttttacc actgccagtg ctcatttaaa agctggctgc ccaatgttgg   5700

ctttggaagt attatcaaag atgcctaaag tcatcaagaa aacaagacct ttttataggg   5760

cttctagttt tctggatact agtaaagact gttctccttc ttctccatta aagttggatg   5820

caagggaaga taagtcttct gctgttgatt ggtcacagtc actgataaat ggttttggat   5880

cttcttcaga gggttcctca gagaagcaat caaactccac tctttctttt gactggagcc   5940

aaccaagtgt tgtgtttcag gatgactctt tagagttaaa atgggacagt gataatgatg   6000

aagaaaatga ggatgtccct atttcaatga aagaactaaa acctttacag agaaaaacag   6060

ataaaaagtt ggatgacata agttctaact acacagaatc tttcagcaca ctagatgaaa   6120

atgacctttt aaatccatca gaagatataa ttgcagttca gttaaaattt agagcatgtt   6180

taaagattct cacagtagaa cttcgtactt tatctactgg ctatgaaata gatggtggaa   6240

aattgcgtta ccaactatac cactggcttg aaaaagaggt gatagctctt cagaggactt   6300

gtgacttttg ctcagatgct gaagaactac agtctgcatt tggcagaaat gaagatgaat   6360

ttggattaaa tgaggatgct gaagatttgc ctcaccaaac aaaagtgaaa caactgagag   6420

aaaattttca ggaaaaaaga cagtggctct tgaagtatca gtcacttttg agaatgtttc   6480

ttagttactg catacttcat ggatcccatg gtgggggtct tgcatctgta agaatggaat   6540

tgattttgct tttgcaagaa tctcagcagg aaacatcaga accactattt tctagccttc   6600

tgtcagagca aacctcagtg cctctcctct ttgcttgtac agccaatgcc aaaacagtag   6660

ttgccaatcc attattgcac cttagtaatc tgacacatga tattctccat gccataataa   6720

actttgattc accaccccac cctgatatcc aaagcaataa agtgtatgta atgcatactt   6780

tagcagcttc actttctgct tgtatttatc agtgcctttg tggtagtcat aactacagtt   6840

catttcagac gaatcagttt actggaatgg tatatcagac agtactgctt cctcatcgac   6900

cttctttgaa aacaggaagc ttagatgaag cattaactcc caatacgtca ccagctcaat   6960

ggccaggaat aacttgtcta attcgacttt tgaattcttc tggcgaggaa gcccagtcag   7020

ggcttacagt cttgctctgt gagattctca cagcagtgta tcttagtctc ttcatccatg   7080

gcctggccac acattcaagt aatgagctat ttcggattgt ggcccatcct ctaaatgaga   7140

aaatgtggtc tgctgtgttt ggtggaggtg cacatgttcc tagcaaagaa cagacacatt   7200

caaaaacttt acctgtttct tcactagttg aagaaggaga aaaacagaac aaacgtttta   7260

ggccgtcaaa aatgtcttgc agagaatctg ccccactgac cccttcctcg gcaccagtaa   7320

gccaggagtc actggcggtt aaagaaaagt tcatcccacc tgagctcagt atctgggact   7380

atttcatagc taagcctttt ctaccctctt ctcaaagtag agccgaatat gattcagagg   7440

agagtctggg aagtgatgat gatgacaatg atgatgatga tgatgtttta gcatcagatt   7500

tccatctcca ggaacattct aattcaaatt catatagttg gtccttgatg cggttggcga   7560

tggtgcaatt ggtgctcaac aatttgaaga ctttttatcc cttcgcaggt catgatcttg   7620

cagagcttcc agttagttca cctctttgtc atgcggttct aaaaactctt caatgttggg   7680

aacaagttct tctccgacga cttgaaatcc atggtgggcc acctcaaaat tatatcgcaa   7740

gtcataccgc cgaagagagt ttgtctgcag gtcctgcaat tcttcgccac aaagctttac   7800

tggaacctac aaacactcct ttcaaatcca aacaccatct ggcactgtct gtgaagaggc   7860

tttggcagta tttggtgaag caggaagaaa ttcaggaaac ctttatcaaa aatatattca   7920

caaagaaacg gtgtctaaat gagatagaag cagatttggg atatcctgga ggtaaagcaa   7980

gaattattca taaggaatct gatatcatta ctgcgtttgc tgttaataag gcaaatagaa   8040

actgcatagc aatcgcttcc agtcatgatg ttcaagaact ggatgtttct ggaattctgg   8100

ccacacaggt ctacacttgg gtagatgatg atatagaagt ggaaaccaaa ggatcagaag   8160

atttcttggt tatacatgct cgtgatgatt ta                                 8192


<210>  1566
<211>  3027
<212>  PRT
<213>  Homosapiens

<400>  1566

Met Asn Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp His 
1               5                   10                  15      


Cys Phe Ser Val Gly Ser Ile Gly Asp Gln Arg Phe Thr Ala Tyr Ala 
            20                  25                  30          


Ser Gly Cys Asp Ile Val Ile Leu Gly Ser Asp Phe Glu Arg Leu Gln 
        35                  40                  45              


Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Gly Cys Val Asp 
    50                  55                  60                  


Cys Ser Met Gln Gln Gly Lys Ile Ala Ala Ser Tyr Gly Asn Val Ile 
65                  70                  75                  80  


Ser Ile Phe Glu Pro Val Asn Leu Pro Lys Gln Lys Lys Asn Leu Glu 
                85                  90                  95      


Leu Tyr Ser Gln Trp Gln Lys Ser Gly Gln Phe Phe Leu Glu Ser Ile 
            100                 105                 110         


Ala His Asn Ile Thr Trp Asp Pro Thr Gly Ser Arg Leu Leu Thr Gly 
        115                 120                 125             


Ser Ser Tyr Leu Gln Leu Trp Ser Asn Thr Asn Leu Glu Lys Pro Thr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Asn Lys Thr Asp Leu Asn Phe Gly Asp Trp Lys 
145                 150                 155                 160 


Cys Ile Trp His Cys Lys Thr Ala Ser Gln Val His Leu Met Lys Phe 
                165                 170                 175     


Ser Pro Asp Gly Glu Phe Phe Ala Thr Ala Gly Lys Asp Asp Cys Leu 
            180                 185                 190         


Leu Lys Val Trp Tyr Asn Val Glu Asn Trp Arg Thr Ala Val Thr Ser 
        195                 200                 205             


Pro Asp Gly Ser Ser Glu Lys Gln Ser Gln Gly Glu Ile Asp Phe Ser 
    210                 215                 220                 


Phe Val Tyr Leu Ala His Pro Arg Ala Val Asn Gly Phe Ser Trp Arg 
225                 230                 235                 240 


Lys Thr Ser Lys Tyr Met Pro Arg Ala Ser Val Cys Asn Val Leu Leu 
                245                 250                 255     


Thr Cys Cys Lys Asp Asn Val Cys Arg Leu Trp Val Glu Thr Phe Leu 
            260                 265                 270         


Pro Asn Asp Cys Leu Leu Tyr Gly Gly Asp Cys Ser His Trp Thr Glu 
        275                 280                 285             


Ser Ile Asn Leu Thr Asn Asn Phe Lys Arg Asn Ala Ser Ser Lys Glu 
    290                 295                 300                 


Arg Val Gln Asn Ala Leu Glu Val Asn Leu Arg His Phe Arg Arg Gly 
305                 310                 315                 320 


Arg Arg Arg Ser Leu Ala Leu Val Ala His Thr Gly Tyr Leu Pro His 
                325                 330                 335     


Gln Gln Asp Pro His His Val His Arg Asn Thr Pro Leu His Ala Asn 
            340                 345                 350         


Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr Asp 
        355                 360                 365             


Ile Pro Leu Leu Pro Ser Ile Thr Ser Leu Ser Leu Asn Glu Asn Glu 
    370                 375                 380                 


Glu Lys Thr Gly Pro Phe Val Val His Trp Leu Asn Asn Lys Glu Leu 
385                 390                 395                 400 


His Phe Thr Leu Ser Met Glu Val Phe Leu Gln Gln Leu Arg Lys Ser 
                405                 410                 415     


Phe Glu Gln Pro Ser Ser Glu Ala Ser Val Glu Asp Ser Asn Gln Ala 
            420                 425                 430         


Asp Val Lys Ser Asp Glu Glu Thr Asp Asp Gly Val Asp Asp Leu Lys 
        435                 440                 445             


Ile Asn Pro Glu Lys Lys Glu Leu Gly Cys Asp Lys Met Val Pro Asn 
    450                 455                 460                 


Ser Ser Phe Thr Ser Leu Ser Ser Ala Ala Ile Asp His Gln Ile Glu 
465                 470                 475                 480 


Val Leu Leu Ser Glu Trp Ser Lys Asn Ala Asp Met Leu Phe Ser Ile 
                485                 490                 495     


His Pro Met Asp Gly Ser Leu Leu Val Trp His Val Asp Trp Leu Asp 
            500                 505                 510         


Glu Tyr Gln Pro Gly Met Phe Arg Gln Val Gln Val Ser Phe Val Ser 
        515                 520                 525             


Arg Ile Pro Val Ala Phe Pro Thr Gly Asp Ala Asn Ser Leu Cys Lys 
    530                 535                 540                 


Ser Ile Met Met Tyr Ala Cys Thr Lys Asn Val Asp Leu Ala Ile Gln 
545                 550                 555                 560 


Gln Gly Lys Gln Lys Pro Ser Gly Leu Thr Arg Ser Thr Ser Met Leu 
                565                 570                 575     


Ile Ser Ser Gly His Asn Lys Ser Ser Asn Ser Leu Lys Leu Ser Ile 
            580                 585                 590         


Phe Thr Pro Asn Val Met Met Ile Ser Lys His Ala Asp Gly Ser Leu 
        595                 600                 605             


Asn Gln Trp Leu Val Ser Phe Ala Glu Glu Ser Ala Phe Ser Thr Val 
    610                 615                 620                 


Leu Ser Ile Ser His Lys Ser Arg Tyr Cys Gly His Arg Phe His Leu 
625                 630                 635                 640 


Asn Asp Leu Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Thr Ser 
                645                 650                 655     


His His Asn Ala Leu Arg Thr Pro Asp Val Asp Asn Pro Glu Gln Pro 
            660                 665                 670         


Phe Asp Ala Leu Asn Ile Glu Glu Cys Ser Leu Thr Gln Gln Asn Lys 
        675                 680                 685             


Ser Thr Val Asp Val Ala Phe Gln Asp Pro Ser Ala Val Tyr Ser Glu 
    690                 695                 700                 


Leu Ile Leu Trp Arg Val Asp Pro Val Gly Pro Leu Ser Phe Ser Gly 
705                 710                 715                 720 


Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His Val Ser Ala Phe 
                725                 730                 735     


Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser Tyr Cys Leu Gly 
            740                 745                 750         


Ala Tyr Cys Asn Ser Pro Ser Ala Cys Phe Val Ala Ser Asp Gly Gln 
        755                 760                 765             


Tyr Leu Arg Leu Tyr Glu Ala Val Ile Asp Ala Lys Lys Leu Leu Ser 
    770                 775                 780                 


Glu Leu Ser Asn Pro Glu Ile Ser Lys Tyr Val Gly Glu Val Phe Asn 
785                 790                 795                 800 


Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys Ile Ile Ala Leu 
                805                 810                 815     


Asp Pro Ile Thr Lys Leu His Gly Arg Lys Thr Gln Leu Leu His Val 
            820                 825                 830         


Phe Glu Glu Asp Phe Ile Leu Asn Asn Leu Glu Lys Lys Ser Leu Gly 
        835                 840                 845             


Lys Asp Ser Ile Leu Ser Asn Ala Gly Ser Ser Pro Asn Gly Phe Ser 
    850                 855                 860                 


Glu Lys Phe Tyr Leu Ile Val Ile Glu Cys Thr Gln Asp Asn Arg Ser 
865                 870                 875                 880 


Leu Leu His Met Trp Asn Leu His Leu Lys Ser Ile Pro Val Ser Leu 
                885                 890                 895     


Asp Glu Lys Val Asp Thr Lys Leu Ser Glu Ala Val Trp Gln Pro Glu 
            900                 905                 910         


Glu His Tyr Ser Ser Ser Pro Glu Lys Ile Leu Ser Pro Phe Ser Gln 
        915                 920                 925             


Lys Tyr Gln Ala Cys Arg Ala Asn Leu Gln Ser Thr Ser Arg Leu Thr 
    930                 935                 940                 


Leu Phe Ser Glu Met Val Tyr Ser Gln Glu Leu His Leu Pro Glu Gly 
945                 950                 955                 960 


Val Glu Ile Ile Ser Ile Lys Pro Ser Ala Gly His Leu Ser Ser Ser 
                965                 970                 975     


Ser Ile Tyr Pro Ala Cys Ser Ala Pro Tyr Leu Leu Ala Thr Ser Cys 
            980                 985                 990         


Ser Asp Glu Lys Val Arg Phe Trp  Arg Cys Arg Val Thr  Asp Gly Glu 
        995                 1000                 1005             


Ser Ala  Thr Ser Lys Asn Gly  Lys Ile Asp Leu Ala  Tyr Ile Trp 
    1010                 1015                 1020             


Glu Glu  Trp Pro Leu Leu Ile  Glu Asp Gly Leu Gln  Ser Asn Ser 
    1025                 1030                 1035             


Ser Ile  Thr Val Pro Gly Arg  Pro Val Glu Val Ser  Cys Ala His 
    1040                 1045                 1050             


Thr Asn  Arg Leu Ala Val Ala  Tyr Lys Gln Pro Ala  Ser Asn Ser 
    1055                 1060                 1065             


Arg Ser  Ser Gln Asp Phe Val  Met His Val Ser Ile  Phe Glu Cys 
    1070                 1075                 1080             


Glu Ser  Thr Gly Gly Ser Cys  Trp Val Leu Glu Gln  Thr Ile His 
    1085                 1090                 1095             


Leu Asp  Glu Leu Ser Thr Val  Leu Asp Ser Gly Ile  Ser Val Asp 
    1100                 1105                 1110             


Ser Asn  Leu Val Ala Tyr Asn  Lys Gln Asp Met Tyr  Leu Ser Ser 
    1115                 1120                 1125             


Lys Glu  Asn Ile Thr Ser Asn  Thr Lys His Leu Val  His Leu Asp 
    1130                 1135                 1140             


Trp Met  Ser Arg Glu Asp Gly  Ser His Ile Leu Thr  Val Gly Ile 
    1145                 1150                 1155             


Gly Ser  Lys Leu Phe Met Tyr  Gly Pro Leu Ala Gly  Lys Val Gln 
    1160                 1165                 1170             


Asp Gln  Thr Gly Lys Glu Thr  Leu Ala Phe Pro Leu  Trp Glu Ser 
    1175                 1180                 1185             


Thr Lys  Val Val Pro Leu Ser  Lys Phe Val Leu Leu  Arg Ser Val 
    1190                 1195                 1200             


Asp Leu  Val Ser Ser Val Asp  Gly Ser Pro Pro Phe  Pro Val Ser 
    1205                 1210                 1215             


Leu Ser  Trp Val Arg Asp Gly  Ile Leu Val Val Gly  Met Asp Cys 
    1220                 1225                 1230             


Glu Met  His Val Tyr Cys Gln  Trp Gln Pro Ser Ser  Lys Gln Glu 
    1235                 1240                 1245             


Pro Val  Ile Thr Asp Ser Tyr  Ser Gly Ser Thr Pro  Ser Ile Thr 
    1250                 1255                 1260             


Ser Leu  Ile Lys Gln Ser Asn  Ser Ser Ser Gly Leu  His Pro Pro 
    1265                 1270                 1275             


Lys Lys  Thr Leu Thr Arg Ser  Met Thr Ser Leu Ala  Gln Lys Ile 
    1280                 1285                 1290             


Cys Gly  Lys Lys Thr Ala Phe  Asp Pro Ser Val Asp  Met Glu Asp 
    1295                 1300                 1305             


Ser Gly  Leu Phe Glu Ala Ala  His Val Leu Ser Pro  Thr Leu Pro 
    1310                 1315                 1320             


Gln Tyr  His Pro Leu Gln Leu  Leu Glu Leu Met Asp  Leu Gly Lys 
    1325                 1330                 1335             


Val Arg  Arg Ala Lys Ala Ile  Leu Ser His Leu Val  Lys Cys Ile 
    1340                 1345                 1350             


Ala Gly  Glu Val Val Ala Leu  Asn Glu Ala Glu Ser  Asn His Glu 
    1355                 1360                 1365             


Arg Arg  Leu Arg Ser Leu Thr  Ile Ser Ala Ser Gly  Ser Thr Thr 
    1370                 1375                 1380             


Arg Asp  Pro Gln Ala Phe Asn  Lys Ala Glu Asn Thr  Asp Tyr Thr 
    1385                 1390                 1395             


Glu Ile  Asp Ser Val Pro Pro  Leu Pro Leu Tyr Ala  Leu Leu Ala 
    1400                 1405                 1410             


Ala Asp  Asp Asp Ser Cys Tyr  Ser Ser Leu Glu Lys  Ser Ser Asn 
    1415                 1420                 1425             


Glu Ser  Thr Leu Ser Lys Ser  Asn Gln Leu Ser Lys  Glu Ser Tyr 
    1430                 1435                 1440             


Asp Glu  Leu Phe Gln Thr Gln  Leu Leu Met Thr Asp  Thr His Met 
    1445                 1450                 1455             


Leu Glu  Thr Asp Glu Glu Asn  Thr Lys Pro Arg Val  Ile Asp Leu 
    1460                 1465                 1470             


Ser Gln  Tyr Ser Pro Thr Tyr  Phe Gly Pro Glu His  Ala Gln Val 
    1475                 1480                 1485             


Leu Ser  Gly His Leu Leu His  Ser Ser Leu Pro Gly  Leu Ser Arg 
    1490                 1495                 1500             


Met Glu  Gln Met Ser Leu Met  Ala Leu Ala Asp Thr  Ile Ala Thr 
    1505                 1510                 1515             


Thr Ser  Thr Asp Ile Gly Glu  Ser Arg Asp Arg Ser  Gln Gly Gly 
    1520                 1525                 1530             


Glu Thr  Leu Asp Glu Cys Gly  Leu Lys Phe Leu Leu  Ala Val Arg 
    1535                 1540                 1545             


Leu His  Thr Phe Leu Thr Thr  Ser Leu Pro Ala Tyr  Arg Ala Gln 
    1550                 1555                 1560             


Leu Leu  His Gln Gly Leu Ser  Thr Ser His Phe Ala  Trp Ala Phe 
    1565                 1570                 1575             


His Ser  Val Ala Glu Glu Glu  Leu Leu Asn Met Leu  Pro Ala Met 
    1580                 1585                 1590             


Gln Lys  Asp Asp Pro Thr Trp  Ser Glu Leu Arg Ala  Met Gly Val 
    1595                 1600                 1605             


Gly Trp  Trp Val Arg Asn Thr  Arg Ile Leu Arg Lys  Cys Ile Glu 
    1610                 1615                 1620             


Lys Val  Ala Lys Ala Ala Phe  Tyr Arg Lys Asn Asp  Pro Leu Asp 
    1625                 1630                 1635             


Ala Ala  Ile Phe Tyr Leu Ala  Met Lys Lys Lys Ala  Val Ile Trp 
    1640                 1645                 1650             


Gly Leu  Tyr Arg Ala Glu Lys  Asn Thr Arg Met Thr  Gln Phe Phe 
    1655                 1660                 1665             


Gly His  Asn Phe Glu Asp Glu  Arg Trp Arg Lys Ala  Ala Leu Lys 
    1670                 1675                 1680             


Asn Ala  Phe Ser Leu Leu Gly  Lys Gln Arg Phe Glu  His Ser Ala 
    1685                 1690                 1695             


Ala Phe  Phe Leu Leu Ala Gly  Cys Leu Arg Asp Ala  Ile Glu Val 
    1700                 1705                 1710             


Cys Leu  Glu Lys Leu Asn Asp  Ile Gln Leu Ala Leu  Val Ile Ala 
    1715                 1720                 1725             


Arg Leu  Tyr Glu Ser Glu Phe  Asp Thr Ser Ala Ala  Tyr Lys Ser 
    1730                 1735                 1740             


Ile Leu  Arg Lys Lys Val Leu  Gly Ile Asp Ser Pro  Val Ser Glu 
    1745                 1750                 1755             


Leu Cys  Ser Leu Asn Ile Asn  Met His His Asp Pro  Phe Leu Arg 
    1760                 1765                 1770             


Ser Met  Ala Tyr Trp Ile Leu  Glu Asp Tyr Ser Gly  Ala Leu Glu 
    1775                 1780                 1785             


Thr Leu  Ile Lys Gln Pro Ile  Arg Glu Asn Asp Asp  Gln Val Leu 
    1790                 1795                 1800             


Ser Ala  Ser Asn Pro Thr Val  Phe Asn Phe Tyr Asn  Tyr Leu Arg 
    1805                 1810                 1815             


Thr His  Pro Leu Leu Leu Arg  Arg His Phe Gly Ser  Ser Asp Thr 
    1820                 1825                 1830             


Phe Ser  Thr His Met Ser Leu  Thr Gly Lys Ser Gly  Leu Ala Gly 
    1835                 1840                 1845             


Thr Ile  Asn Leu Ser Glu Arg  Arg Leu Phe Phe Thr  Thr Ala Ser 
    1850                 1855                 1860             


Ala His  Leu Lys Ala Gly Cys  Pro Met Leu Ala Leu  Glu Val Leu 
    1865                 1870                 1875             


Ser Lys  Met Pro Lys Val Ile  Lys Lys Thr Arg Pro  Phe Tyr Arg 
    1880                 1885                 1890             


Ala Ser  Ser Phe Leu Asp Thr  Ser Lys Asp Cys Ser  Pro Ser Ser 
    1895                 1900                 1905             


Pro Leu  Lys Leu Asp Ala Arg  Glu Asp Lys Ser Ser  Ala Val Asp 
    1910                 1915                 1920             


Trp Ser  Gln Ser Leu Ile Asn  Gly Phe Gly Ser Ser  Ser Glu Gly 
    1925                 1930                 1935             


Ser Ser  Glu Lys Gln Ser Asn  Ser Thr Leu Ser Phe  Asp Trp Ser 
    1940                 1945                 1950             


Gln Pro  Ser Val Val Phe Gln  Asp Asp Ser Leu Glu  Leu Lys Trp 
    1955                 1960                 1965             


Asp Ser  Asp Asn Asp Glu Glu  Asn Glu Asp Val Pro  Ile Ser Met 
    1970                 1975                 1980             


Lys Glu  Leu Lys Pro Leu Gln  Arg Lys Thr Asp Lys  Lys Leu Asp 
    1985                 1990                 1995             


Asp Ile  Ser Ser Asn Tyr Thr  Glu Ser Phe Ser Thr  Leu Asp Glu 
    2000                 2005                 2010             


Asn Asp  Leu Leu Asn Pro Ser  Glu Asp Ile Ile Ala  Val Gln Leu 
    2015                 2020                 2025             


Lys Phe  Arg Ala Cys Leu Lys  Ile Leu Thr Val Glu  Leu Arg Thr 
    2030                 2035                 2040             


Leu Ser  Thr Gly Tyr Glu Ile  Asp Gly Gly Lys Leu  Arg Tyr Gln 
    2045                 2050                 2055             


Leu Tyr  His Trp Leu Glu Lys  Glu Val Ile Ala Leu  Gln Arg Thr 
    2060                 2065                 2070             


Cys Asp  Phe Cys Ser Asp Ala  Glu Glu Leu Gln Ser  Ala Phe Gly 
    2075                 2080                 2085             


Arg Asn  Glu Asp Glu Phe Gly  Leu Asn Glu Asp Ala  Glu Asp Leu 
    2090                 2095                 2100             


Pro His  Gln Thr Lys Val Lys  Gln Leu Arg Glu Asn  Phe Gln Glu 
    2105                 2110                 2115             


Lys Arg  Gln Trp Leu Leu Lys  Tyr Gln Ser Leu Leu  Arg Met Phe 
    2120                 2125                 2130             


Leu Ser  Tyr Cys Ile Leu His  Gly Ser His Gly Gly  Gly Leu Ala 
    2135                 2140                 2145             


Ser Val  Arg Met Glu Leu Ile  Leu Leu Leu Gln Glu  Ser Gln Gln 
    2150                 2155                 2160             


Glu Thr  Ser Glu Pro Leu Phe  Ser Ser Leu Leu Ser  Glu Gln Thr 
    2165                 2170                 2175             


Ser Val  Pro Leu Leu Phe Ala  Cys Thr Ala Asn Ala  Lys Thr Val 
    2180                 2185                 2190             


Val Ala  Asn Pro Leu Leu His  Leu Ser Asn Leu Thr  His Asp Ile 
    2195                 2200                 2205             


Leu His  Ala Ile Ile Asn Phe  Asp Ser Pro Pro His  Pro Asp Ile 
    2210                 2215                 2220             


Gln Ser  Asn Lys Val Tyr Val  Met His Thr Leu Ala  Ala Ser Leu 
    2225                 2230                 2235             


Ser Ala  Cys Ile Tyr Gln Cys  Leu Cys Gly Ser His  Asn Tyr Ser 
    2240                 2245                 2250             


Ser Phe  Gln Thr Asn Gln Phe  Thr Gly Met Val Tyr  Gln Thr Val 
    2255                 2260                 2265             


Leu Leu  Pro His Arg Pro Ser  Leu Lys Thr Gly Ser  Leu Asp Glu 
    2270                 2275                 2280             


Ala Leu  Thr Pro Asn Thr Ser  Pro Ala Gln Trp Pro  Gly Ile Thr 
    2285                 2290                 2295             


Cys Leu  Ile Arg Leu Leu Asn  Ser Ser Gly Glu Glu  Ala Gln Ser 
    2300                 2305                 2310             


Gly Leu  Thr Val Leu Leu Cys  Glu Ile Leu Thr Ala  Val Tyr Leu 
    2315                 2320                 2325             


Ser Leu  Phe Ile His Gly Leu  Ala Thr His Ser Ser  Asn Glu Leu 
    2330                 2335                 2340             


Phe Arg  Ile Val Ala His Pro  Leu Asn Glu Lys Met  Trp Ser Ala 
    2345                 2350                 2355             


Val Phe  Gly Gly Gly Ala His  Val Pro Ser Lys Glu  Gln Thr His 
    2360                 2365                 2370             


Ser Lys  Thr Leu Pro Val Ser  Ser Leu Val Glu Glu  Gly Glu Lys 
    2375                 2380                 2385             


Gln Asn  Lys Arg Phe Arg Pro  Ser Lys Met Ser Cys  Arg Glu Ser 
    2390                 2395                 2400             


Ala Pro  Leu Thr Pro Ser Ser  Ala Pro Val Ser Gln  Glu Ser Leu 
    2405                 2410                 2415             


Ala Val  Lys Glu Lys Phe Ile  Pro Pro Glu Leu Ser  Ile Trp Asp 
    2420                 2425                 2430             


Tyr Phe  Ile Ala Lys Pro Phe  Leu Pro Ser Ser Gln  Ser Arg Ala 
    2435                 2440                 2445             


Glu Tyr  Asp Ser Glu Glu Ser  Leu Gly Ser Asp Asp  Asp Asp Asn 
    2450                 2455                 2460             


Asp Asp  Asp Asp Asp Val Leu  Ala Ser Asp Phe His  Leu Gln Glu 
    2465                 2470                 2475             


His Ser  Asn Ser Asn Ser Tyr  Ser Trp Ser Leu Met  Arg Leu Ala 
    2480                 2485                 2490             


Met Val  Gln Leu Val Leu Asn  Asn Leu Lys Thr Phe  Tyr Pro Phe 
    2495                 2500                 2505             


Ala Gly  His Asp Leu Ala Glu  Leu Pro Val Ser Ser  Pro Leu Cys 
    2510                 2515                 2520             


His Ala  Val Leu Lys Thr Leu  Gln Cys Trp Glu Gln  Val Leu Leu 
    2525                 2530                 2535             


Arg Arg  Leu Glu Ile His Gly  Gly Pro Pro Gln Asn  Tyr Ile Ala 
    2540                 2545                 2550             


Ser His  Thr Ala Glu Glu Ser  Leu Ser Ala Gly Pro  Ala Ile Leu 
    2555                 2560                 2565             


Arg His  Lys Ala Leu Leu Glu  Pro Thr Asn Thr Pro  Phe Lys Ser 
    2570                 2575                 2580             


Lys His  His Leu Ala Leu Ser  Val Lys Arg Leu Trp  Gln Tyr Leu 
    2585                 2590                 2595             


Val Lys  Gln Glu Glu Ile Gln  Glu Thr Phe Ile Lys  Asn Ile Phe 
    2600                 2605                 2610             


Thr Lys  Lys Arg Cys Leu Asn  Glu Ile Glu Ala Asp  Leu Gly Tyr 
    2615                 2620                 2625             


Pro Gly  Gly Lys Ala Arg Ile  Ile His Lys Glu Ser  Asp Ile Ile 
    2630                 2635                 2640             


Thr Ala  Phe Ala Val Asn Lys  Ala Asn Arg Asn Cys  Ile Ala Ile 
    2645                 2650                 2655             


Ala Ser  Ser His Asp Val Gln  Glu Leu Asp Val Ser  Gly Ile Leu 
    2660                 2665                 2670             


Ala Thr  Gln Val Tyr Thr Trp  Val Asp Asp Asp Ile  Glu Val Glu 
    2675                 2680                 2685             


Thr Lys  Gly Ser Glu Asp Phe  Leu Val Ile His Ala  Arg Asp Asp 
    2690                 2695                 2700             


Leu Thr  Ala Val Gln Gly Thr  Thr Pro Tyr Thr His  Ser Asn Pro 
    2705                 2710                 2715             


Gly Thr  Pro Ile Asn Met Pro  Trp Leu Gly Ser Thr  Gln Thr Gly 
    2720                 2725                 2730             


Arg Gly  Ala Ser Val Met Ile  Lys Lys Ala Ile Asn  Asn Val Arg 
    2735                 2740                 2745             


Arg Met  Thr Ser His Pro Thr  Leu Pro Tyr Tyr Leu  Thr Gly Ala 
    2750                 2755                 2760             


Gln Asp  Gly Ser Val Arg Met  Phe Glu Trp Gly His  Ser Gln Gln 
    2765                 2770                 2775             


Ile Thr  Cys Phe Arg Ser Gly  Gly Asn Ser Arg Val  Thr Arg Met 
    2780                 2785                 2790             


Arg Phe  Asn Tyr Gln Gly Asn  Lys Phe Gly Ile Val  Asp Ala Asp 
    2795                 2800                 2805             


Gly Tyr  Leu Ser Leu Tyr Gln  Thr Asn Trp Lys Cys  Cys Pro Val 
    2810                 2815                 2820             


Thr Gly  Ser Met Pro Lys Pro  Tyr Leu Thr Trp Gln  Cys His Asn 
    2825                 2830                 2835             


Lys Thr  Ala Asn Asp Phe Val  Phe Val Ser Ser Ser  Ser Leu Ile 
    2840                 2845                 2850             


Ala Thr  Ala Gly Leu Ser Thr  Asp Asn Arg Asn Val  Cys Leu Trp 
    2855                 2860                 2865             


Asp Thr  Leu Val Ala Pro Ala  Asn Ser Leu Val His  Ala Phe Thr 
    2870                 2875                 2880             


Cys His  Asp Ser Gly Ala Thr  Val Leu Ala Tyr Ala  Pro Lys His 
    2885                 2890                 2895             


Gln Leu  Leu Ile Ser Gly Gly  Arg Lys Gly Phe Thr  Tyr Val Phe 
    2900                 2905                 2910             


Asp Leu  Cys Gln Arg Gln Gln  Arg Gln Leu Phe Gln  Ser His Asp 
    2915                 2920                 2925             


Ser Pro  Val Lys Ala Val Ala  Val Asp Pro Thr Glu  Glu Tyr Phe 
    2930                 2935                 2940             


Val Thr  Gly Ser Ala Glu Gly  Asn Ile Lys Ile Trp  Ser Leu Ser 
    2945                 2950                 2955             


Thr Phe  Gly Leu Leu His Thr  Phe Val Ser Glu His  Ala Arg Gln 
    2960                 2965                 2970             


Ser Ile  Phe Arg Asn Ile Gly  Thr Gly Val Met Gln  Ile Glu Thr 
    2975                 2980                 2985             


Gly Pro  Ala Asn His Ile Phe  Ser Cys Gly Ala Asp  Gly Thr Met 
    2990                 2995                 3000             


Lys Met  Arg Ile Leu Pro Asp  Gln Phe Ser Pro Leu  Asn Glu Val 
    3005                 3010                 3015             


Leu Lys  Asn Asp Val Lys Phe  Met Leu 
    3020                 3025         


<210>  1567
<211>  1642
<212>  DNA
<213>  Homosapiens

<400>  1567
atgtacctgc acgtatacca ggtacacgca gacagatgcg ggccatcccc agagccgccg     60

acagaggtcg ctgcgagacg gtacccgcgc cccacagtcc acccgctcct cggagtcccc    120

ccgcgccccg gagtccaccc gcgccccgga gtccacccgc gcaggtccac ttctccatcc    180

ctgctctcga cctccgcccc tgcggtgggg gaagttcctg gggcggtggc tgggaccagg    240

ccgggtttta ggcgggcgca gatttccggg ctaactttcc tcgccgtctc agcgcgggaa    300

gggggaaatg ggaaacccgg gccagagcag cggagcttcc cagccgcaca cttcctccct    360

ccagccgttt gtctcggcag gggagggccc aggcagccaa gccggcaggc ccactggtta    420

tccgaccttg tgctctggcc gtgggtggag accttacatc cagctcagag cgcctcctcc    480

catcccctgt gtcctctagg cctccccaga ctttgccttt tagccttcca gtgaaacaag    540

ttctgtatcc aagatataca attaagtgga caaagcagat tgcagaaagt cttttcgtag    600

ctcacaaggg gacatcaaag atgacaaaga ggagtggaag aagacagaga gaatcaatgt    660

gaggagcctg gaacagggct ctgaattgtc ttcccacagt gaaatcactt gtctattgct    720

gagccaagaa tttgactctg agcatctagg atgagaaaga agaactggca cctacgccat    780

ctctgcccct cgggactgac tattttggcc cagtttcctc aacaatgaaa tgggactaat    840

tatcccaggt cacacttctc tctgggctta ccctgggaat cagatgattg agctttggat    900

ctcactctgt tgcccaggct ggaatgcagt gatacgatca tgactcactg cagcctcaaa    960

ctcctgggtt caagtaaccc tcccacctca gctttctgag taactgggac tacagaatgc   1020

cccaccccac ttagtccata gtgatgccca cctgtggtta atggagctga ggctgctgga   1080

ccaaagggag gaagtctgtt aggcatatgt ggaacccaaa agaggaactt catcaactgt   1140

catggacagc tctgccactt tgtgaccctg tggacttttt gggaagtgtt tttgtggttc   1200

accagtctct cattaggcaa ggccatttgt cctgggttgg tcttcttcat tggtggaaag   1260

tacagctggg agatttggaa tggttgcaga ttgacttgac tctcataagg aactgccacc   1320

atgagctttt ggggaaagac ctcaagctgt ggtgtgttgc tgaggattgt gggattcctc   1380

caaatcttgg ggaacatttt gagtcatcac tggcagcaga tttctgttga caacttgagc   1440

aacttcagaa tgaagaagcc atcttcatct ctcacatgaa tatgactttg ggtaaatcat   1500

ctcgaaatct gaacccatgg ttgtgatcca cactcctcct gagttctgat ttttagtgta   1560

acctttttct tctcattttt tcttctttgt gcatctctta aggaggtttt taaaatctca   1620

taattaaaaa atttatttct tc                                            1642


<210>  1568
<211>  177
<212>  PRT
<213>  Homosapiens

<400>  1568

Met Tyr Leu His Val Tyr Gln Val His Ala Asp Arg Cys Gly Pro Ser 
1               5                   10                  15      


Pro Glu Pro Pro Thr Glu Val Ala Ala Arg Arg Tyr Pro Arg Pro Thr 
            20                  25                  30          


Val His Pro Leu Leu Gly Val Pro Pro Arg Pro Gly Val His Pro Arg 
        35                  40                  45              


Pro Gly Val His Pro Arg Arg Ser Thr Ser Pro Ser Leu Leu Ser Thr 
    50                  55                  60                  


Ser Ala Pro Ala Val Gly Glu Val Pro Gly Ala Val Ala Gly Thr Arg 
65                  70                  75                  80  


Pro Gly Phe Arg Arg Ala Gln Ile Ser Gly Leu Thr Phe Leu Ala Val 
                85                  90                  95      


Ser Ala Arg Glu Gly Gly Asn Gly Lys Pro Gly Pro Glu Gln Arg Ser 
            100                 105                 110         


Phe Pro Ala Ala His Phe Leu Pro Pro Ala Val Cys Leu Gly Arg Gly 
        115                 120                 125             


Gly Pro Arg Gln Pro Ser Arg Gln Ala His Trp Leu Ser Asp Leu Val 
    130                 135                 140                 


Leu Trp Pro Trp Val Glu Thr Leu His Pro Ala Gln Ser Ala Ser Ser 
145                 150                 155                 160 


His Pro Leu Cys Pro Leu Gly Leu Pro Arg Leu Cys Leu Leu Ala Phe 
                165                 170                 175     


Gln 
    


<210>  1569
<211>  1062
<212>  DNA
<213>  Homosapiens

<400>  1569
atgcgggaga aaaacctgct gccgttgcta atggccccag tgttcttccc tcgcaggcag     60

aaattatgca ggcttctgtc tcgcggcttc tccctttacc cagcgccttg taataaatgc    120

ccaaacaaga gagccttctg ctgcactgtc tgtgaagttc cagggtctgg gccaattctg    180

cagataggct ccgtgccctg ggagggcacc acttttcatc cctcgcctgc agtgcccccc    240

aatctccgtt tagtcacagc gatgcctaaa ggaaagaagg ccaaggggaa gaaggtggct    300

gcggcccctg ctgtcatgaa gaagcaggag gtcaagcaag tggtgaatcc cctgtttgag    360

gaaaggccta agaattttgg cattggacag gacatccagc ccaaaagaga cctcacccac    420

tttgtgaaat gaccctgcta tatcaggttg cagcggcaga gagccatcct ctataggcag    480

ctgaaagtgc ctcctgtgat taaccagttc acccaagccc tggaccacca aacagctact    540

tagctgctta agctggccta cacatgcaaa acagagacaa agcaagagaa gaagcagagg    600

ctgttggcct gggctgagaa gaaagctgct ggcaaagggg atgtccccac taagagacca    660

cctgtccttc gagcaggagt taacaccatc accaccttgg tggagaataa gaaagctcag    720

ctggtggtga ttgcacacaa cgtgcatccc actgagctgg tgggcttctt gcctgccctg    780

tgttgtaaaa tgcgggtccc ttactgcatt attaagggga aggcaagact gggacatcta    840

gtccacagga agacctgcac cactgtcacc ttcacacagg ttaactcgga agacaaaggc    900

gctttggcta aactggtgga agctatcagg accaattatg atgacagata cgatgagatc    960

cactgtcact ggggaggcaa tgtcctgggt cacaagtctg tggctcatgt caccaagctc   1020

gaaaaggcaa aggctagaga acttgccact aaactgggtt aa                      1062


<210>  1570
<211>  353
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (144)..(144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (181)..(181)
<223>  Xaa can be any naturally occurring amino acid

<400>  1570

Met Arg Glu Lys Asn Leu Leu Pro Leu Leu Met Ala Pro Val Phe Phe 
1               5                   10                  15      


Pro Arg Arg Gln Lys Leu Cys Arg Leu Leu Ser Arg Gly Phe Ser Leu 
            20                  25                  30          


Tyr Pro Ala Pro Cys Asn Lys Cys Pro Asn Lys Arg Ala Phe Cys Cys 
        35                  40                  45              


Thr Val Cys Glu Val Pro Gly Ser Gly Pro Ile Leu Gln Ile Gly Ser 
    50                  55                  60                  


Val Pro Trp Glu Gly Thr Thr Phe His Pro Ser Pro Ala Val Pro Pro 
65                  70                  75                  80  


Asn Leu Arg Leu Val Thr Ala Met Pro Lys Gly Lys Lys Ala Lys Gly 
                85                  90                  95      


Lys Lys Val Ala Ala Ala Pro Ala Val Met Lys Lys Gln Glu Val Lys 
            100                 105                 110         


Gln Val Val Asn Pro Leu Phe Glu Glu Arg Pro Lys Asn Phe Gly Ile 
        115                 120                 125             


Gly Gln Asp Ile Gln Pro Lys Arg Asp Leu Thr His Phe Val Lys Xaa 
    130                 135                 140                 


Pro Cys Tyr Ile Arg Leu Gln Arg Gln Arg Ala Ile Leu Tyr Arg Gln 
145                 150                 155                 160 


Leu Lys Val Pro Pro Val Ile Asn Gln Phe Thr Gln Ala Leu Asp His 
                165                 170                 175     


Gln Thr Ala Thr Xaa Leu Leu Lys Leu Ala Tyr Thr Cys Lys Thr Glu 
            180                 185                 190         


Thr Lys Gln Glu Lys Lys Gln Arg Leu Leu Ala Trp Ala Glu Lys Lys 
        195                 200                 205             


Ala Ala Gly Lys Gly Asp Val Pro Thr Lys Arg Pro Pro Val Leu Arg 
    210                 215                 220                 


Ala Gly Val Asn Thr Ile Thr Thr Leu Val Glu Asn Lys Lys Ala Gln 
225                 230                 235                 240 


Leu Val Val Ile Ala His Asn Val His Pro Thr Glu Leu Val Gly Phe 
                245                 250                 255     


Leu Pro Ala Leu Cys Cys Lys Met Arg Val Pro Tyr Cys Ile Ile Lys 
            260                 265                 270         


Gly Lys Ala Arg Leu Gly His Leu Val His Arg Lys Thr Cys Thr Thr 
        275                 280                 285             


Val Thr Phe Thr Gln Val Asn Ser Glu Asp Lys Gly Ala Leu Ala Lys 
    290                 295                 300                 


Leu Val Glu Ala Ile Arg Thr Asn Tyr Asp Asp Arg Tyr Asp Glu Ile 
305                 310                 315                 320 


His Cys His Trp Gly Gly Asn Val Leu Gly His Lys Ser Val Ala His 
                325                 330                 335     


Val Thr Lys Leu Glu Lys Ala Lys Ala Arg Glu Leu Ala Thr Lys Leu 
            340                 345                 350         


Gly 
    


<210>  1571
<211>  453
<212>  DNA
<213>  Homosapiens

<400>  1571
atgggtttta agaaaagtcg aaaacctagt tgcccagact attgtccaag ggatatcacc     60

agcaaggaca aaaatgcccg gatggataac actggtatga atccaggcat tggatcaggg    120

gtcatgcttt ccagtgaaga cctaggaaag gatgttgaat ttgaagttgt tggtgatgcc    180

ccagaaaaag tggggcccaa acaagctgaa gatgctgcca aaagcataac caaaggcagt    240

gatgatggag ctcagccctc cacctccaca gctcaagagc aagatgatgt tctcatagtt    300

gattaggatg aagaagattc ttcaaataat gccgacgtca gtgaggaaga gagaagccgc    360

aagaagaaat tagatgagaa agagaatctc agtgcaaaga ggtcacgtat agaacagaag    420

gaagagcttg atgatgtcat agcattagat tga                                 453


<210>  1572
<211>  150
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<400>  1572

Met Gly Phe Lys Lys Ser Arg Lys Pro Ser Cys Pro Asp Tyr Cys Pro 
1               5                   10                  15      


Arg Asp Ile Thr Ser Lys Asp Lys Asn Ala Arg Met Asp Asn Thr Gly 
            20                  25                  30          


Met Asn Pro Gly Ile Gly Ser Gly Val Met Leu Ser Ser Glu Asp Leu 
        35                  40                  45              


Gly Lys Asp Val Glu Phe Glu Val Val Gly Asp Ala Pro Glu Lys Val 
    50                  55                  60                  


Gly Pro Lys Gln Ala Glu Asp Ala Ala Lys Ser Ile Thr Lys Gly Ser 
65                  70                  75                  80  


Asp Asp Gly Ala Gln Pro Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp 
                85                  90                  95      


Val Leu Ile Val Asp Xaa Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp 
            100                 105                 110         


Val Ser Glu Glu Glu Arg Ser Arg Lys Lys Lys Leu Asp Glu Lys Glu 
        115                 120                 125             


Asn Leu Ser Ala Lys Arg Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp 
    130                 135                 140                 


Asp Val Ile Ala Leu Asp 
145                 150 


<210>  1573
<211>  1352
<212>  DNA
<213>  Homosapiens

<400>  1573
gtgctgtgag gcttgcccgc ggacagtaaa cttgcagggg cgagagggag ggacatcgat     60

taaacctaaa tcgtgggcgt tcagtcctca gggcaccgag cgcgtgaaaa ctccagcgga    120

ctctgctgga aaggagatca tgccctctaa gtctctttcc aacctctcgg tgaccaccgg    180

cgcgaatgag agcggttccg ttcccgaggg gtgggaaagg gatttcctgc cggcctcgga    240

cgggaccacc acggagttgg tgatccgctg tgtgatcccg tccctctacc tgctcatcat    300

caccgtgggc ttgctgggca acatcatgct ggtgaagatc ttcatcacca acagcgccat    360

gaggagcgtc cccaacatct tcatctctaa cctggcggcc ggggacttgc tgctgctgct    420

cacctgcgtc ccggtggacg cctcgcgcta cttcttcgac gagtggatgt ttggcaaggt    480

gggctgcaaa ctgatccctg tcatccagct cacttccgtg ggggtttccg tgttcactct    540

cactgccctc agcgccgaca ggtacagagc catcgttaac cccatggaca tgcagacgtc    600

aggggcattg ctgcggacct gtgtgaaggc catgggtatc tgggtggtct ccgtgttgct    660

ggcagttccc gaagcggtgt tttcagaagt ggctcgcatc agtagcttgg ataatagcag    720

cttcacagca tgtatcccat accctcaaac agatgaatta catccaaaga ttcattcagt    780

gctcattttc ttggtctatt tcctcatacc acttgctatt attagcattt attattatca    840

tattgcaaag accttaatta aaagcgcaca caatcttcct ggagaataca atgaacatac    900

caaaaaacag atggaaacac ggaaacgcct ggctaaaatt gtgcttgtct ttgtgggctg    960

tttcatcttc tgttggtttc caaaccacat cctttacatg tatcggtctt tcaactataa   1020

tgagattgat ccatctctag gccacatgat tgtcacctta gttgcccggg ttctcagttt   1080

tggcaattct tgtgtcaacc catttgctct ttacctactc agtgaaagct tcaggaggca   1140

tttcaacagc caactctgct gtgggaggaa gtcctatcaa gagagaggaa ccagctacct   1200

actcagctct tcagcggtgc gtatgacatc tctgaaaagc aatgctaaga acatggtgac   1260

caattctgtt ttactaaatg ggcacagcat gaagcaggaa atggcaatgt gattttggcc   1320

attcaactca ctacctggag agaacttagt aa                                 1352


<210>  1574
<211>  390
<212>  PRT
<213>  Homosapiens

<400>  1574

Met Pro Ser Lys Ser Leu Ser Asn Leu Ser Val Thr Thr Gly Ala Asn 
1               5                   10                  15      


Glu Ser Gly Ser Val Pro Glu Gly Trp Glu Arg Asp Phe Leu Pro Ala 
            20                  25                  30          


Ser Asp Gly Thr Thr Thr Glu Leu Val Ile Arg Cys Val Ile Pro Ser 
        35                  40                  45              


Leu Tyr Leu Leu Ile Ile Thr Val Gly Leu Leu Gly Asn Ile Met Leu 
    50                  55                  60                  


Val Lys Ile Phe Ile Thr Asn Ser Ala Met Arg Ser Val Pro Asn Ile 
65                  70                  75                  80  


Phe Ile Ser Asn Leu Ala Ala Gly Asp Leu Leu Leu Leu Leu Thr Cys 
                85                  90                  95      


Val Pro Val Asp Ala Ser Arg Tyr Phe Phe Asp Glu Trp Met Phe Gly 
            100                 105                 110         


Lys Val Gly Cys Lys Leu Ile Pro Val Ile Gln Leu Thr Ser Val Gly 
        115                 120                 125             


Val Ser Val Phe Thr Leu Thr Ala Leu Ser Ala Asp Arg Tyr Arg Ala 
    130                 135                 140                 


Ile Val Asn Pro Met Asp Met Gln Thr Ser Gly Ala Leu Leu Arg Thr 
145                 150                 155                 160 


Cys Val Lys Ala Met Gly Ile Trp Val Val Ser Val Leu Leu Ala Val 
                165                 170                 175     


Pro Glu Ala Val Phe Ser Glu Val Ala Arg Ile Ser Ser Leu Asp Asn 
            180                 185                 190         


Ser Ser Phe Thr Ala Cys Ile Pro Tyr Pro Gln Thr Asp Glu Leu His 
        195                 200                 205             


Pro Lys Ile His Ser Val Leu Ile Phe Leu Val Tyr Phe Leu Ile Pro 
    210                 215                 220                 


Leu Ala Ile Ile Ser Ile Tyr Tyr Tyr His Ile Ala Lys Thr Leu Ile 
225                 230                 235                 240 


Lys Ser Ala His Asn Leu Pro Gly Glu Tyr Asn Glu His Thr Lys Lys 
                245                 250                 255     


Gln Met Glu Thr Arg Lys Arg Leu Ala Lys Ile Val Leu Val Phe Val 
            260                 265                 270         


Gly Cys Phe Ile Phe Cys Trp Phe Pro Asn His Ile Leu Tyr Met Tyr 
        275                 280                 285             


Arg Ser Phe Asn Tyr Asn Glu Ile Asp Pro Ser Leu Gly His Met Ile 
    290                 295                 300                 


Val Thr Leu Val Ala Arg Val Leu Ser Phe Gly Asn Ser Cys Val Asn 
305                 310                 315                 320 


Pro Phe Ala Leu Tyr Leu Leu Ser Glu Ser Phe Arg Arg His Phe Asn 
                325                 330                 335     


Ser Gln Leu Cys Cys Gly Arg Lys Ser Tyr Gln Glu Arg Gly Thr Ser 
            340                 345                 350         


Tyr Leu Leu Ser Ser Ser Ala Val Arg Met Thr Ser Leu Lys Ser Asn 
        355                 360                 365             


Ala Lys Asn Met Val Thr Asn Ser Val Leu Leu Asn Gly His Ser Met 
    370                 375                 380                 


Lys Gln Glu Met Ala Met 
385                 390 


<210>  1575
<211>  3273
<212>  DNA
<213>  Homosapiens

<400>  1575
gagttcggag tagagatggc cgcgcttgca ccgctgcccc cgctccccgc acagttcaag     60

agcatacagc atcatctgag gacggctcag gagcatgaca agcgagaccc tgtggtggct    120

tattactgtc gtttatacgc aatgcagact ggaatgaaga tcgatagtaa aactcctgaa    180

tgtcgcaaat ttttatcaaa gttaatggat cagttagaag ctctaaagaa gcagttgggt    240

gataatgaag ctattactca agaaatagtg ggctgtgcac atttggagaa ttatgctttg    300

aaaatgtttt tgtatgcaga caatgaagat cgtgctggac gatttcacaa aaacatgatc    360

aagtccttct atactgcaag tcttttgata gatgtcataa cagtatttgg agaactcact    420

gatgaaaatg tgaaacacag gaagtatgcc agatggaagg caacatacat ccataattgt    480

ttaaagaatg gggagactcc tcaagcaggc cctgttggaa ttgaagaaga taatgatatt    540

gaagaaaatg aagatgctgg agcagcctct ctgcccactc agccaactca gccatcatca    600

tcttcaactt atgacccaag caacatgcca tcaggcaact atactggaat acagattcct    660

ccgggtgcgc acgctccagc taatacacca gcagaagtgc ctcacagcac aggtgtagca    720

agtaatacta tccaacctac tccacagact atacctgcca ttgatcccgc acttttcaat    780

acaatttccc agggggatgt tcgtctaacc ccagaagact ttgctagagc tcagaagtac    840

tgcaaatatg ctggcagtgc tttgcagtat gaagatgtaa gcactgctgt ccagaatcta    900

caaaaggctc tcaagttact gacgacaggc agagaatgaa gcctttgtat gacagaccca    960

tgtatttttg gcatgaggaa ctaacagtcc attactctat cttcagccta tcaggatcac   1020

agttttaagg aagacttggt tttgttgaat atgacaatga aatctgtgtg tatcagattt   1080

ttattgaagc attcatcagc agcctcaacc agttttcatt gtccatttac tagattcaat   1140

cgtctctgag tatatagggc tgatgttagc aagaccctaa aaatgtccat tgaaccctgc   1200

ttcaaaaaat gaaaacacac ctctataaaa tgtgtactgg gaataagctt tgtatttaca   1260

tacattaggg gaatttttta aaatctgtaa tgtttggaca aacagatgat attactttgc   1320

tataaaatta taaatgtaac ttttaataaa gatagccaga atattctaaa ttagaaatta   1380

cgtttttgtt tccctcaaga cataaaacaa atataaacat tctaaactgc tggatgaatc   1440

tgaaaagaca ttaagttcaa attttaattt attctcatat taaatataac tccattaaaa   1500

gtttaaaatt tcatgggaga aaatataata aggtaaagag gtagaatcac tttcagactt   1560

aagaataatg ttgatttccc aagtgcttta ccttatctgt taaagcgtaa gatgaattgg   1620

tatttgcttc ataggcagtt tgactgcatg tattagagaa tgaaaagaag atatttgtag   1680

taatgcctgg aaacttggtg ctttaaatta aggtactcct ctgctgctgt agaatggatt   1740

ccacacagtg gatagctatg ggtgattcag aatattatgt ttagattccc atttgttaag   1800

tttataagtt ttgtggggaa ttatgaactt actgtgtact acctgcattt gtgctgtgtg   1860

aaaaataaat acaaggattc gtttagctaa ttcaacttac tacaaagaca aatgtctgtt   1920

tttatttgcc tgctaggatt gtctttttta aaagtcattt ttatttatag gaatatgggt   1980

gtttctatag gaagaaacag gttttttgtt ttttgttttt taagataaat ttgacaaagt   2040

taactgaaat ttatctggtc cattttattc atgctactaa gatgggaatc tttaaacaca   2100

agggtcagca agctttggcc catggattgg ccacctgtta cgtaaataaa gtttctttga   2160

aacaagccta cactcattca tttatgtttt gtctgtggtt gctttccaca actgcagagt   2220

tgtatggctt gcaagtctaa aaacatttac tatttggccc tctaagaaaa agttaagaca   2280

cctagtctaa tggccttttg ggaaaaaaca aatcactaac tcataatcat ttatatccat   2340

tattttctgc ataaatgtaa tgctattgta cagggtttgg tagaataaat attcagactg   2400

actaaactgt tctaaatcct cacaaaaaag tccccaaaca acatgcctcc taaaaaacat   2460

tttcctatct tttacaagag gtatgaacat ttgtagggtt ccacatttgc atctagaaat   2520

ccaatgctct ttagaatgtt attacgaata gaaagatggc caggatgacc tttagtgtta   2580

catgatgttc agcaaatttt aattcaaacc ttgatatgcc tggacactga aaagtaaacg   2640

catcacctcc tattttatac cctaccttct ggttcccaat tgggagagca catagaggga   2700

aggagacaat atagaaacta cggagtccgc tggtagtggg ctgcatggtg tgacagagcc   2760

cttctctgta aaatggaaat gacaccacta gccatctcaa tagttacaag aattaaaaga   2820

gatacagtac ctgaagtgct tagcgcatgg tagcatttca taaatgttta gtgtcaatac   2880

taatgctcta ataatgtaaa ttgttaataa tttatttccc taatatcagg aaatcccagt   2940

tgtctatgtg gcccagtgct taaaaacgcc ttcttgcatg aggggattga actatacaat   3000

gtttgttaac tttgtatttg tattttttcc tataaaatct taaaataaaa ttaggagatg   3060

tgttctgatg taacagtagg attagcaatt ttcatttatt ccttccatat atatttactg   3120

aatggctact atatgcctgg tattgttctt tgaaagcaga aacagcagga aaaaaagtcc   3180

ctccctcata gagtttacat tctaaaaggg aggaaataga taataaaata tacattacat   3240

ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                3273


<210>  1576
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  1576

Met Ala Ala Leu Ala Pro Leu Pro Pro Leu Pro Ala Gln Phe Lys Ser 
1               5                   10                  15      


Ile Gln His His Leu Arg Thr Ala Gln Glu His Asp Lys Arg Asp Pro 
            20                  25                  30          


Val Val Ala Tyr Tyr Cys Arg Leu Tyr Ala Met Gln Thr Gly Met Lys 
        35                  40                  45              


Ile Asp Ser Lys Thr Pro Glu Cys Arg Lys Phe Leu Ser Lys Leu Met 
    50                  55                  60                  


Asp Gln Leu Glu Ala Leu Lys Lys Gln Leu Gly Asp Asn Glu Ala Ile 
65                  70                  75                  80  


Thr Gln Glu Ile Val Gly Cys Ala His Leu Glu Asn Tyr Ala Leu Lys 
                85                  90                  95      


Met Phe Leu Tyr Ala Asp Asn Glu Asp Arg Ala Gly Arg Phe His Lys 
            100                 105                 110         


Asn Met Ile Lys Ser Phe Tyr Thr Ala Ser Leu Leu Ile Asp Val Ile 
        115                 120                 125             


Thr Val Phe Gly Glu Leu Thr Asp Glu Asn Val Lys His Arg Lys Tyr 
    130                 135                 140                 


Ala Arg Trp Lys Ala Thr Tyr Ile His Asn Cys Leu Lys Asn Gly Glu 
145                 150                 155                 160 


Thr Pro Gln Ala Gly Pro Val Gly Ile Glu Glu Asp Asn Asp Ile Glu 
                165                 170                 175     


Glu Asn Glu Asp Ala Gly Ala Ala Ser Leu Pro Thr Gln Pro Thr Gln 
            180                 185                 190         


Pro Ser Ser Ser Ser Thr Tyr Asp Pro Ser Asn Met Pro Ser Gly Asn 
        195                 200                 205             


Tyr Thr Gly Ile Gln Ile Pro Pro Gly Ala His Ala Pro Ala Asn Thr 
    210                 215                 220                 


Pro Ala Glu Val Pro His Ser Thr Gly Val Ala Ser Asn Thr Ile Gln 
225                 230                 235                 240 


Pro Thr Pro Gln Thr Ile Pro Ala Ile Asp Pro Ala Leu Phe Asn Thr 
                245                 250                 255     


Ile Ser Gln Gly Asp Val Arg Leu Thr Pro Glu Asp Phe Ala Arg Ala 
            260                 265                 270         


Gln Lys Tyr Cys Lys Tyr Ala Gly Ser Ala Leu Gln Tyr Glu Asp Val 
        275                 280                 285             


Ser Thr Ala Val Gln Asn Leu Gln Lys Ala Leu Lys Leu Leu Thr Thr 
    290                 295                 300                 


Gly Arg Glu 
305         


<210>  1577
<211>  6864
<212>  DNA
<213>  Homosapiens

<400>  1577
ccaagtacct agggtggtgg ccgagtcccg cctcccgcca gcgggggcga ggacctgcga     60

cgcgcacccc tgcctggccc ggtctcctca gcaccagccc cacgcacacc ctacttcctc    120

agcttctcgc cctcaccctg ccaacttccc tgcgaggagg gacctgccgc cagcctgctt    180

cctcgtccgc aggccctgcg ctgaacgctg ccgcgcccag ggttcacctt gcgccgtcgg    240

gaaagcccat gaactctcca gaaacggcgt aaaggagggt cccgccgcgg cgcagggctg    300

gggcgcctgg gttccccctg ggtggagcag cggcagcaga gcgggaaagt ggtggaggat    360

gatcttgcgg ccaaagggga cctcggcgca gtaatgtcaa catgatgttt cgctcagatc    420

gaatgtggag ctgccattgg aaatggaagc ccagtcctct cctgttctta tttgctttat    480

atatcatgtg tgttcctcac tcagtgtggg gatgtgccaa ctgccgagtg gttttgtcca    540

acccttctgg gacctttact tctccatgct accctaacga ctacccaaac agccaggctt    600

gcatgtggac gctccgagcc cccaccggtt atatcattca gataacattt aacgactttg    660

acattgaaga agctcccaat tgcatttatg actcattatc ccttgataat ggagagagcc    720

agactaaatt ttgtggagca actgccaaag gcctatcatt taactcaagt gcgaatgaga    780

tgcatgtgtc cttttcaagt gactttagca tccagaagaa aggtttcaat gccagctaca    840

tcagagttgc cgtgtcctta aggaatcaaa aggtcatttt accccagaca tcagatgctt    900

accaggtatc tgttgcaaaa agcatctcta ttccagagct cagtgctttc acactctgct    960

ttgaagcaac caaagttggc catgaagaca gtgattggac agctttctcc tactcaaatg   1020

catccttcac acaattgctc agttttggaa aggccaagag tggctacttt ctatccattt   1080

ctgattcaaa atgtttgttg aataatgcat tacctgtcaa agaaaaagaa gacatttttg   1140

cagaaagctt tgaacagctc tgccttgttt ggaataattc tttgggctct attggtgtaa   1200

atttcaaaag aaactatgaa acagttccat gtgattctac cattagtaaa gttattcctg   1260

ggaatgggaa attgttgttg ggctccaatc aaaatgaaat tgtctctcta aaaggggaca   1320

tttataactt tcgactttgg aattttacca tgaatgccaa aatcctctcc aacctcagct   1380

gtaatgtgaa agggaatgta gtcgactggc aaaatgactt ctggaatatc ccaaacctag   1440

ctctgaaagc tgaaagcaac ctaagctgtg gttcctacct gatcccgctc ccagcagcag   1500

aactggccag ctgtgcagac ctggggaccc tctgtcaaga tggaattatc tatagaatat   1560

ccgtagtgat tcagaacatc cttcgtcacc ctgaggtaaa agtacagagc aaggtggcag   1620

aatggctcaa ttcaaccttc caaaattgga actacacggt ttatgtcgtt aatatcagtt   1680

ttcacctgag tgctggagag gacaagatta aagtcaagag aagccttgag gatgagccaa   1740

ggttggtgct ttgggccctt ctagtttaca atgctaccaa caatactaat ttagaaggaa   1800

aaatcattca gcagaagctc ctaaaaaata atgagtcctt ggatgaaggc ttgaggctac   1860

atacagtgaa tgtgagacaa ctgggtcatt gtcttgccat ggaggaaccc aaaggctact   1920

actggccatc tatccaacct tctgaatacg ttcttccttg tccagacaag cctggctttt   1980

ctgcttctcg gatatgtttt tacaatgcta ccaacccatt ggtaacctac tggggacctg   2040

ttgatatctc caactgttta aaagaagcaa atgaagttgc taaccagatt ttaaatttaa   2100

ctgctgatgg gcagaactta acctcagcca atattaccaa cattgtggaa caggtcaaaa   2160

gaattgtgaa taaagaagaa aacattgata taacacttgg ctcaactcta atgaatatat   2220

tttctaatat cttaagcagt tcagacagtg acttgcttga gtcatcttct gaagctttaa   2280

aaacaattga tgaattggcc ttcaagatag acctaaatag cacatcacat gtgaatatta   2340

caactcggaa cttggctctc agcgtatcat ccctgttacc agggacaaat gcaatttcaa   2400

attttagcat tggtcttcca agcaataatg aatcgtattt ccagatggat tttgagagtg   2460

gacaagtgga tccactggca tctgtaattt tgcctccaaa cttacttgag aatttaagtc   2520

cagaagattc tgtattagtt agaagagcac agtttacttt cttcaacaaa actggacttt   2580

tccaggatgt aggaccccaa agaaaaactt tagtgagtta tgtgatggcg tgcagtattg   2640

gaaacattac tatccagaat ctgaaggatc ctgttcaaat aaaaatcaaa catacaagaa   2700

ctcaggaagt gcatcatccc atctgtgcct tctgggatct gaacaaaaac aaaagttttg   2760

gaggatggaa cacgtcagga tgtgttgcac acagagattc agatgcaagt gagacagtct   2820

gcctgtgtaa ccacttcaca cactttggag ttctgatgga ccttccaaga agtgcctcac   2880

agttagatgc aagaaacact aaagtcctca ctttcatcag ctatattggg tgtggaatat   2940

ctgctatttt ttcagcagca actctcctga catatgttgc ttttgagaaa ttgcgaaggg   3000

attatccctc caaaatcttg atgaacctga gcacagccct gctgttcctg aatctcctct   3060

tcctcctaga tggctggatc acctccttca atgtggatgg actttgcatt gctgttgcag   3120

tcctgttgca tttcttcctt ctggcaacct ttacctggat ggggctagaa gcaattcaca   3180

tgtacattgc tctagttaaa gtatttaaca cttacattcg ccgatacatt ctaaaattct   3240

gcatcattgg ctggggtttg cctgccttag tggtgtcagt tgttctagcg agcagaaaca   3300

acaatgaagt ctatggaaaa gaaagttatg ggaaagaaaa aggtgatgaa ttctgttgga   3360

ttcaagatcc agtcatattt tatgtgacct gtgctgggta ttttggagtc atgttttttc   3420

tgaacattgc catgttcatt gtggtaatgg tgcagatctg tgggaggaat ggcaagagaa   3480

gcaaccggac cctgagagaa gaagtgttaa ggaacctgcg cagtgtggtt agcttgacct   3540

ttctgttggg catgacatgg ggttttgcat tctttgcctg gggaccctta aatatcccct   3600

tcatgtacct cttctccatc ttcaattcat tacaaggctt atttatattc atcttccact   3660

gtgctatgaa ggagaatgtt cagaaacagt ggcggcggca tctctgctgt ggtagatttc   3720

ggttagcaga taactcagat tggagtaaga cagctaccaa tatcatcaag aaaagttctg   3780

ataatctagg aaaatctttg tcttcaagct ccattggttc caactcaacc tatcttacat   3840

ccaaatctaa atccagctct accacctatt tcaaaaggaa tagccacaca gataatgtct   3900

cctatgagca ttccttcaac aaaagtggat cactcagaca gtgcttccat ggacaagtcc   3960

ttgtcaaaac tggcccatgc tgatggagat caaacatcaa tcatccctgt ccatcaggtc   4020

attgataagg tcaagggtta ttgcaatgct cattcagaca acttctataa aaatattatc   4080

atgtcagaca ccttcagcca cagcacaaag ttttaatgtc tttaagaaaa agaaatcaat   4140

ctgcagaaat gtgaagattt gcaagcagtg taaactgcaa ctagtgatgt aaatgtgcta   4200

ttacctaggt aactgcatat atataaggaa tgtattttgt taagaaggct tttgtgaaat   4260

tcagaatttt tctttttaat atatttcttc catggaagag ttgtcatcac taaaacttca   4320

gtactgagag taacatgact cagtagccac agaagctatg atttgtaaaa tatataattg   4380

aatcagagta atcataatgc aggggagaca ttcaaattag agacaaggga gaagcaatgc   4440

tgaggaagac cctagataga gctcatttta ctccacctaa tcgttatatc tggatatacc   4500

cattttctgc atcttctttc tcaacaataa aaaatgtaac tattttgaat gcccacaaat   4560

cccattccag tgttactttc tgtgaatgca gtaccatatt ctcattttca atgacatttc   4620

aaccacaggc agaaaagact gtttactcct tgacccaaag attaaaaagg attttttatt   4680

attttaaata ttacaccttc agaaccataa catgcttaag aaaactttcc caaaatgttg   4740

acctagttaa atgaggctat ataaatttct aatattttac ttattctatt caaggcatag   4800

ggccaaagca ttaagtataa tttaatccca tacattcgag ttaagtttag tgttgatgtt   4860

ccatcattct ggacctccca ggagttgttt aagaatgaat ctcttacacc tctacttttg   4920

cccctctact gtatattaag cccataggct tgtgggagga aggagaattt ccattaggca   4980

agctgtatgc agtggaattt tccttttagg agacacacaa ttaagactct ctggttctgt   5040

ccttgctttg gagactttaa gacatttcct aaagcacaaa taaaagcctc gtatttcccc   5100

attgagagtt ttgttccaag gaatatgaag tgagacatat gggtgagtca taataatcaa   5160

aataatttat gaagagctgg gtctgcaata gctagtctaa aaactacttg tgtgtcagtc   5220

ctctggttat agtatataag agcctgagga ggtctggcaa gatagatggt gtattattta   5280

tggatcaggc tgctgcatac aaaccttgca tactattatg cagcttacct aactctcaga   5340

ctattctgag taatgcttgc ttgctaatga atgtatagga gaccacattg taattgttct   5400

tagatgatgg agtccatgca gtttcttaga aatcggtctc agtgcatgct gtgctttttc   5460

acatttgctc tgggttatct gggaagtatc aggttctggg aggcaacagc attaagtgat   5520

aagaaaagga gacattctgg caaagccaat ctgcttaaag gcaaagtcca gaacctggaa   5580

cctagaggcc tttctctctg cacgaaaaac aggtagtttg cagtctgaga tatgggagag   5640

cttttaggct acacagcaac ccaagggacc tctcaccttt tgctgagctt caatcaggaa   5700

gctatttgcc tggctccagc agatgatgag ataatgaggt agtgggtttt ttattactgt   5760

tccattttgc aacatcctgc aacaccatcc tgggagacaa gagcattacc cagcttggct   5820

ttcacggggg agggttgtat tcagtaaaaa agaatagtaa atataaggtc actgagattc   5880

taagtaagat agtaaatcta aggtcactga gccaaatcct tttcaatagg catatattaa   5940

caggctgctt attttggcgg aggttacata tggatgaaaa tgaatcttag tcactgaata   6000

ttcatataca tttcccccaa aaccttagac attcatagta gattttaatt agttagcttt   6060

ctaactagtc agatttctgc ccaaagtgct tagtcaatag taattaagat ataggtaatt   6120

aagatatagc ttcaaaaatg gctttgcttt tgatttctac tcatattcgt atggctccag   6180

aaaaatattt ttttcatatt tgacaatgtc agctccactt tagaaatttt caataaccag   6240

atgagaaaaa aattaagaaa ttgctcaagg gaaacatttg taaatggatt tgaaagattg   6300

agccaaattc tgttgtcagt tctaagcatg cagttctcac ctccatttag tcccccatca   6360

gaacagaggt caggaattta gctggggagc ctaaatttag ttcagcttac ctttgagaat   6420

agcatcaatt cagactctct tttcattatg ttttcttttc tttttccctc tttttaaact   6480

acattgtgtt agagtcatag tctaggatcc tgagagattt tccattcttg tcaccattca   6540

cttgcattgt aaagattttc tttgtctgtt gttggcatag attcttttgt acatatttat   6600

ttatttgtgt ttatatatgt caattggttt cctttcttag cttgatattg cctagctttg   6660

ttgttttaat taactttcta ttagagagac tgtatatatt ttttctaaat actttgtgaa   6720

atcatttttg gtagcaatat ctttgaatat gatgaataaa agtgactgtg agtgcaaata   6780

gaattagcag taagaagcta ctctagctaa tttgccattt tacttaaatg gaaaatgttt   6840

ttcaaataaa tacttatgtt gttc                                          6864


<210>  1578
<211>  1193
<212>  PRT
<213>  Homosapiens

<400>  1578

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Arg His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Asn  Val Ser Tyr Glu His  Ser Phe Asn 
    1160                 1165                 1170             


Lys Ser  Gly Ser Leu Arg Gln  Cys Phe His Gly Gln  Val Leu Val 
    1175                 1180                 1185             


Lys Thr  Gly Pro Cys 
    1190             


<210>  1579
<211>  6818
<212>  DNA
<213>  Homosapiens

<400>  1579
ccaagtacct agggtggtgg ccgagtcccg cctcccgcca gcgggggcga ggacctgcga     60

cgcgcacccc tgcctggccc ggtctcctca gcaccagccc cacgcacacc ctacttcctc    120

agcttctcgc cctcaccctg ccaacttccc tgcgaggagg gacctgccgc cagcctgctt    180

cctcgtccgc aggccctgcg ctgaacgctg ccgcgcccag ggttcacctt gcgccgtcgg    240

gaaagcccat gaactctcca gaaacggcgt aaaggagggt cccgccgcgg cgcagggctg    300

gggcgcctgg gttccccctg ggtggagcag cggcagcaga gcgggaaagt ggtggaggat    360

gatcttgcgg ccaaagggga cctcggcgca gtaatgtcaa catgatgttt cgctcagatc    420

gaatgtggag ctgccattgg aaatggaagc ccagtcctct cctgttctta tttgctttat    480

atatcatgtg tgttcctcac tcagtgtggg gatgtgccaa ctgccgagtg gttttgtcca    540

acccttctgg gacctttact tctccatgct accctaacga ctacccaaac agccaggctt    600

gcatgtggac gctccgagcc cccaccggtt atatcattca gataacattt aacgactttg    660

acattgaaga agctcccaat tgcatttatg actcattatc ccttgataat ggagagagcc    720

agactaaatt ttgtggagca actgccaaag gcctatcatt taactcaagt gcgaatgaga    780

tgcatgtgtc cttttcaagt gactttagca tccagaagaa aggtttcaat gccagctaca    840

tcagagttgc cgtgtcctta aggaatcaaa aggtcatttt accccagaca tcagatgctt    900

accaggtatc tgttgcaaaa agcatctcta ttccagagct cagtgctttc acactctgct    960

ttgaagcaac caaagttggc catgaagaca gtgattggac agctttctcc tactcaaatg   1020

catccttcac acaattgctc agttttggaa aggccaagag tggctacttt ctatccattt   1080

ctgattcaaa atgtttgttg aataatgcat tacctgtcaa agaaaaagaa gacatttttg   1140

cagaaagctt tgaacagctc tgccttgttt ggaataattc tttgggctct attggtgtaa   1200

atttcaaaag aaactatgaa acagttccat gtgattctac cattagtaaa gttattcctg   1260

ggaatgggaa attgttgttg ggctccaatc aaaatgaaat tgtctctcta aaaggggaca   1320

tttataactt tcgactttgg aattttacca tgaatgccaa aatcctctcc aacctcagct   1380

gtaatgtgaa agggaatgta gtcgactggc aaaatgactt ctggaatatc ccaaacctag   1440

ctctgaaagc tgaaagcaac ctaagctgtg gttcctacct gatcccgctc ccagcagcag   1500

aactggccag ctgtgcagac ctggggaccc tctgtcaaga tggaattatc tatagaatat   1560

ccgtagtgat tcagaacatc cttcgtcacc ctgaggtaaa agtacagagc aaggtggcag   1620

aatggctcaa ttcaaccttc caaaattgga actacacggt ttatgtcgtt aatatcagtt   1680

ttcacctgag tgctggagag gacaagatta aagtcaagag aagccttgag gatgagccaa   1740

ggttggtgct ttgggccctt ctagtttaca atgctaccaa caatactaat ttagaaggaa   1800

aaatcattca gcagaagctc ctaaaaaata atgagtcctt ggatgaaggc ttgaggctac   1860

atacagtgaa tgtgagacaa ctgggtcatt gtcttgccat ggaggaaccc aaaggctact   1920

actggccatc tatccaacct tctgaatacg ttcttccttg tccagacaag cctggctttt   1980

ctgcttctcg gatatgtttt tacaatgcta ccaacccatt ggtaacctac tggggacctg   2040

ttgatatctc caactgttta aaagaagcaa atgaagttgc taaccagatt ttaaatttaa   2100

ctgctgatgg gcagaactta acctcagcca atattaccaa cattgtggaa caggtcaaaa   2160

gaattgtgaa taaagaagaa aacattgata taacacttgg ctcaactcta atgaatatat   2220

tttctaatat cttaagcagt tcagacagtg acttgcttga gtcatcttct gaagctttaa   2280

aaacaattga tgaattggcc ttcaagatag acctaaatag cacatcacat gtgaatatta   2340

caactcggaa cttggctctc agcgtatcat ccctgttacc agggacaaat gcaatttcaa   2400

attttagcat tggtcttcca agcaataatg aatcgtattt ccagatggat tttgagagtg   2460

gacaagtgga tccactggca tctgtaattt tgcctccaaa cttacttgag aatttaagtc   2520

cagaagattc tgtattagtt agaagagcac agtttacttt cttcaacaaa actggacttt   2580

tccaggatgt aggaccccaa agaaaaactt tagtgagtta tgtgatggcg tgcagtattg   2640

gaaacattac tatccagaat ctgaaggatc ctgttcaaat aaaaatcaaa catacaagaa   2700

ctcaggaagt gcatcatccc atctgtgcct tctgggatct gaacaaaaac aaaagttttg   2760

gaggatggaa cacgtcagga tgtgttgcac acagagattc agatgcaagt gagacagtct   2820

gcctgtgtaa ccacttcaca cactttggag ttctgatgga ccttccaaga agtgcctcac   2880

agttagatgc aagaaacact aaagtcctca ctttcatcag ctatattggg tgtggaatat   2940

ctgctatttt ttcagcagca actctcctga catatgttgc ttttgagaaa ttgcgaaggg   3000

attatccctc caaaatcttg atgaacctga gcacagccct gctgttcctg aatctcctct   3060

tcctcctaga tggctggatc acctccttca atgtggatgg actttgcatt gctgttgcag   3120

tcctgttgca tttcttcctt ctggcaacct ttacctggat ggggctagaa gcaattcaca   3180

tgtacattgc tctagttaaa gtatttaaca cttacattcg ccgatacatt ctaaaattct   3240

gcatcattgg ctggggtttg cctgccttag tggtgtcagt tgttctagcg agcagaaaca   3300

acaatgaagt ctatggaaaa gaaagttatg ggaaagaaaa aggtgatgaa ttctgttgga   3360

ttcaagatcc agtcatattt tatgtgacct gtgctgggta ttttggagtc atgttttttc   3420

tgaacattgc catgttcatt gtggtaatgg tgcagatctg tgggaggaat ggcaagagaa   3480

gcaaccggac cctgagagaa gaagtgttaa ggaacctgcg cagtgtggtt agcttgacct   3540

ttctgttggg catgacatgg ggttttgcat tctttgcctg gggaccctta aatatcccct   3600

tcatgtacct cttctccatc ttcaattcat tacaaggctt atttatattc atcttccact   3660

gtgctatgaa ggagaatgtt cagaaacagt ggcggcggca tctctgctgt ggtagatttc   3720

ggttagcaga taactcagat tggagtaaga cagctaccaa tatcatcaag aaaagttctg   3780

ataatctagg aaaatctttg tcttcaagct ccattggttc caactcaacc tatcttacat   3840

ccaaatctaa atccagctct accacctatt tcaaaaggaa tagccacaca gacagtgctt   3900

ccatggacaa gtccttgtca aaactggccc atgctgatgg agatcaaaca tcaatcatcc   3960

ctgtccatca ggtcattgat aaggtcaagg gttattgcaa tgctcattca gacaacttct   4020

ataaaaatat tatcatgtca gacaccttca gccacagcac aaagttttaa tgtctttaag   4080

aaaaagaaat caatctgcag aaatgtgaag atttgcaagc agtgtaaact gcaactagtg   4140

atgtaaatgt gctattacct aggtaactgc atatatataa ggaatgtatt ttgttaagaa   4200

ggcttttgtg aaattcagaa tttttctttt taatatattt cttccatgga agagttgtca   4260

tcactaaaac ttcagtactg agagtaacat gactcagtag ccacagaagc tatgatttgt   4320

aaaatatata attgaatcag agtaatcata atgcagggga gacattcaaa ttagagacaa   4380

gggagaagca atgctgagga agaccctaga tagagctcat tttactccac ctaatcgtta   4440

tatctggata tacccatttt ctgcatcttc tttctcaaca ataaaaaatg taactatttt   4500

gaatgcccac aaatcccatt ccagtgttac tttctgtgaa tgcagtacca tattctcatt   4560

ttcaatgaca tttcaaccac aggcagaaaa gactgtttac tccttgaccc aaagattaaa   4620

aaggattttt tattatttta aatattacac cttcagaacc ataacatgct taagaaaact   4680

ttcccaaaat gttgacctag ttaaatgagg ctatataaat ttctaatatt ttacttattc   4740

tattcaaggc atagggccaa agcattaagt ataatttaat cccatacatt cgagttaagt   4800

ttagtgttga tgttccatca ttctggacct cccaggagtt gtttaagaat gaatctctta   4860

cacctctact tttgcccctc tactgtatat taagcccata ggcttgtggg aggaaggaga   4920

atttccatta ggcaagctgt atgcagtgga attttccttt taggagacac acaattaaga   4980

ctctctggtt ctgtccttgc tttggagact ttaagacatt tcctaaagca caaataaaag   5040

cctcgtattt ccccattgag agttttgttc caaggaatat gaagtgagac atatgggtga   5100

gtcataataa tcaaaataat ttatgaagag ctgggtctgc aatagctagt ctaaaaacta   5160

cttgtgtgtc agtcctctgg ttatagtata taagagcctg aggaggtctg gcaagataga   5220

tggtgtatta tttatggatc aggctgctgc atacaaacct tgcatactat tatgcagctt   5280

acctaactct cagactattc tgagtaatgc ttgcttgcta atgaatgtat aggagaccac   5340

attgtaattg ttcttagatg atggagtcca tgcagtttct tagaaatcgg tctcagtgca   5400

tgctgtgctt tttcacattt gctctgggtt atctgggaag tatcaggttc tgggaggcaa   5460

cagcattaag tgataagaaa aggagacatt ctggcaaagc caatctgctt aaaggcaaag   5520

tccagaacct ggaacctaga ggcctttctc tctgcacgaa aaacaggtag tttgcagtct   5580

gagatatggg agagctttta ggctacacag caacccaagg gacctctcac cttttgctga   5640

gcttcaatca ggaagctatt tgcctggctc cagcagatga tgagataatg aggtagtggg   5700

ttttttatta ctgttccatt ttgcaacatc ctgcaacacc atcctgggag acaagagcat   5760

tacccagctt ggctttcacg ggggagggtt gtattcagta aaaaagaata gtaaatataa   5820

ggtcactgag attctaagta agatagtaaa tctaaggtca ctgagccaaa tccttttcaa   5880

taggcatata ttaacaggct gcttattttg gcggaggtta catatggatg aaaatgaatc   5940

ttagtcactg aatattcata tacatttccc ccaaaacctt agacattcat agtagatttt   6000

aattagttag ctttctaact agtcagattt ctgcccaaag tgcttagtca atagtaatta   6060

agatataggt aattaagata tagcttcaaa aatggctttg cttttgattt ctactcatat   6120

tcgtatggct ccagaaaaat atttttttca tatttgacaa tgtcagctcc actttagaaa   6180

ttttcaataa ccagatgaga aaaaaattaa gaaattgctc aagggaaaca tttgtaaatg   6240

gatttgaaag attgagccaa attctgttgt cagttctaag catgcagttc tcacctccat   6300

ttagtccccc atcagaacag aggtcaggaa tttagctggg gagcctaaat ttagttcagc   6360

ttacctttga gaatagcatc aattcagact ctcttttcat tatgttttct tttctttttc   6420

cctcttttta aactacattg tgttagagtc atagtctagg atcctgagag attttccatt   6480

cttgtcacca ttcacttgca ttgtaaagat tttctttgtc tgttgttggc atagattctt   6540

ttgtacatat ttatttattt gtgtttatat atgtcaattg gtttcctttc ttagcttgat   6600

attgcctagc tttgttgttt taattaactt tctattagag agactgtata tattttttct   6660

aaatactttg tgaaatcatt tttggtagca atatctttga atatgatgaa taaaagtgac   6720

tgtgagtgca aatagaatta gcagtaagaa gctactctag ctaatttgcc attttactta   6780

aatggaaaat gtttttcaaa taaatactta tgttgttc                           6818


<210>  1580
<211>  1222
<212>  PRT
<213>  Homosapiens

<400>  1580

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Arg His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Ser  Ala Ser Met Asp Lys  Ser Leu Ser 
    1160                 1165                 1170             


Lys Leu  Ala His Ala Asp Gly  Asp Gln Thr Ser Ile  Ile Pro Val 
    1175                 1180                 1185             


His Gln  Val Ile Asp Lys Val  Lys Gly Tyr Cys Asn  Ala His Ser 
    1190                 1195                 1200             


Asp Asn  Phe Tyr Lys Asn Ile  Ile Met Ser Asp Thr  Phe Ser His 
    1205                 1210                 1215             


Ser Thr  Lys Phe 
    1220         


<210>  1581
<211>  6948
<212>  DNA
<213>  Homosapiens

<400>  1581
ccaagtacct agggtggtgg ccgagtcccg cctcccgcca gcgggggcga ggacctgcga     60

cgcgcacccc tgcctggccc ggtctcctca gcaccagccc cacgcacacc ctacttcctc    120

agcttctcgc cctcaccctg ccaacttccc tgcgaggagg gacctgccgc cagcctgctt    180

cctcgtccgc aggccctgcg ctgaacgctg ccgcgcccag ggttcacctt gcgccgtcgg    240

gaaagcccat gaactctcca gaaacggcgt aaaggagggt cccgccgcgg cgcagggctg    300

gggcgcctgg gttccccctg ggtggagcag cggcagcaga gcgggaaagt ggtggaggat    360

gatcttgcgg ccaaagggga cctcggcgca gtaatgtcaa catgatgttt cgctcagatc    420

gaatgtggag ctgccattgg aaatggaagc ccagtcctct cctgttctta tttgctttat    480

atatcatgtg tgttcctcac tcagtgtggg gatgtgccaa ctgccgagtg gttttgtcca    540

acccttctgg gacctttact tctccatgct accctaacga ctacccaaac agccaggctt    600

gcatgtggac gctccgagcc cccaccggtt atatcattca gataacattt aacgactttg    660

acattgaaga agctcccaat tgcatttatg actcattatc ccttgataat ggagagagcc    720

agactaaatt ttgtggagca actgccaaag gcctatcatt taactcaagt gcgaatgaga    780

tgcatgtgtc cttttcaagt gactttagca tccagaagaa aggtttcaat gccagctaca    840

tcagagttgc cgtgtcctta aggaatcaaa aggtcatttt accccagaca tcagatgctt    900

accaggtatc tgttgcaaaa agcatctcta ttccagagct cagtgctttc acactctgct    960

ttgaagcaac caaagttggc catgaagaca gtgattggac agctttctcc tactcaaatg   1020

catccttcac acaattgctc agttttggaa aggccaagag tggctacttt ctatccattt   1080

ctgattcaaa atgtttgttg aataatgcat tacctgtcaa agaaaaagaa gacatttttg   1140

cagaaagctt tgaacagctc tgccttgttt ggaataattc tttgggctct attggtgtaa   1200

atttcaaaag aaactatgaa acagttccat gtgattctac cattagtaaa gttattcctg   1260

ggaatgggaa attgttgttg ggctccaatc aaaatgaaat tgtctctcta aaaggggaca   1320

tttataactt tcgactttgg aattttacca tgaatgccaa aatcctctcc aacctcagct   1380

gtaatgtgaa agggaatgta gtcgactggc aaaatgactt ctggaatatc ccaaacctag   1440

ctctgaaagc tgaaagcaac ctaagctgtg gttcctacct gatcccgctc ccagcagcag   1500

aactggccag ctgtgcagac ctggggaccc tctgtcaagc tactgtaaac tctcctagta   1560

ctacaccacc cactgtcacc actaacatgc ctgttactaa cagaatcgat aaacaaagga   1620

atgatggaat tatctataga atatccgtag tgattcagaa catccttcgt caccctgagg   1680

taaaagtaca gagcaaggtg gcagaatggc tcaattcaac cttccaaaat tggaactaca   1740

cggtttatgt cgttaatatc agttttcacc tgagtgctgg agaggacaag attaaagtca   1800

agagaagcct tgaggatgag ccaaggttgg tgctttgggc ccttctagtt tacaatgcta   1860

ccaacaatac taatttagaa ggaaaaatca ttcagcagaa gctcctaaaa aataatgagt   1920

ccttggatga aggcttgagg ctacatacag tgaatgtgag acaactgggt cattgtcttg   1980

ccatggagga acccaaaggc tactactggc catctatcca accttctgaa tacgttcttc   2040

cttgtccaga caagcctggc ttttctgctt ctcggatatg tttttacaat gctaccaacc   2100

cattggtaac ctactgggga cctgttgata tctccaactg tttaaaagaa gcaaatgaag   2160

ttgctaacca gattttaaat ttaactgctg atgggcagaa cttaacctca gccaatatta   2220

ccaacattgt ggaacaggtc aaaagaattg tgaataaaga agaaaacatt gatataacac   2280

ttggctcaac tctaatgaat atattttcta atatcttaag cagttcagac agtgacttgc   2340

ttgagtcatc ttctgaagct ttaaaaacaa ttgatgaatt ggccttcaag atagacctaa   2400

atagcacatc acatgtgaat attacaactc ggaacttggc tctcagcgta tcatccctgt   2460

taccagggac aaatgcaatt tcaaatttta gcattggtct tccaagcaat aatgaatcgt   2520

atttccagat ggattttgag agtggacaag tggatccact ggcatctgta attttgcctc   2580

caaacttact tgagaattta agtccagaag attctgtatt agttagaaga gcacagttta   2640

ctttcttcaa caaaactgga cttttccagg atgtaggacc ccaaagaaaa actttagtga   2700

gttatgtgat ggcgtgcagt attggaaaca ttactatcca gaatctgaag gatcctgttc   2760

aaataaaaat caaacataca agaactcagg aagtgcatca tcccatctgt gccttctggg   2820

atctgaacaa aaacaaaagt tttggaggat ggaacacgtc aggatgtgtt gcacacagag   2880

attcagatgc aagtgagaca gtctgcctgt gtaaccactt cacacacttt ggagttctga   2940

tggaccttcc aagaagtgcc tcacagttag atgcaagaaa cactaaagtc ctcactttca   3000

tcagctatat tgggtgtgga atatctgcta ttttttcagc agcaactctc ctgacatatg   3060

ttgcttttga gaaattgcga agggattatc cctccaaaat cttgatgaac ctgagcacag   3120

ccctgctgtt cctgaatctc ctcttcctcc tagatggctg gatcacctcc ttcaatgtgg   3180

atggactttg cattgctgtt gcagtcctgt tgcatttctt ccttctggca acctttacct   3240

ggatggggct agaagcaatt cacatgtaca ttgctctagt taaagtattt aacacttaca   3300

ttcgccgata cattctaaaa ttctgcatca ttggctgggg tttgcctgcc ttagtggtgt   3360

cagttgttct agcgagcaga aacaacaatg aagtctatgg aaaagaaagt tatgggaaag   3420

aaaaaggtga tgaattctgt tggattcaag atccagtcat attttatgtg acctgtgctg   3480

ggtattttgg agtcatgttt tttctgaaca ttgccatgtt cattgtggta atggtgcaga   3540

tctgtgggag gaatggcaag agaagcaacc ggaccctgag agaagaagtg ttaaggaacc   3600

tgcgcagtgt ggttagcttg acctttctgt tgggcatgac atggggtttt gcattctttg   3660

cctggggacc cttaaatatc cccttcatgt acctcttctc catcttcaat tcattacaag   3720

gcttatttat attcatcttc cactgtgcta tgaaggagaa tgttcagaaa cagtggcggc   3780

ggcatctctg ctgtggtaga tttcggttag cagataactc agattggagt aagacagcta   3840

ccaatatcat caagaaaagt tctgataatc taggaaaatc tttgtcttca agctccattg   3900

gttccaactc aacctatctt acatccaaat ctaaatccag ctctaccacc tatttcaaaa   3960

ggaatagcca cacagataat gtctcctatg agcattcctt caacaaaagt ggatcactca   4020

gacagtgctt ccatggacaa gtccttgtca aaactggccc atgctgatgg agatcaaaca   4080

tcaatcatcc ctgtccatca ggtcattgat aaggtcaagg gttattgcaa tgctcattca   4140

gacaacttct ataaaaatat tatcatgtca gacaccttca gccacagcac aaagttttaa   4200

tgtctttaag aaaaagaaat caatctgcag aaatgtgaag atttgcaagc agtgtaaact   4260

gcaactagtg atgtaaatgt gctattacct aggtaactgc atatatataa ggaatgtatt   4320

ttgttaagaa ggcttttgtg aaattcagaa tttttctttt taatatattt cttccatgga   4380

agagttgtca tcactaaaac ttcagtactg agagtaacat gactcagtag ccacagaagc   4440

tatgatttgt aaaatatata attgaatcag agtaatcata atgcagggga gacattcaaa   4500

ttagagacaa gggagaagca atgctgagga agaccctaga tagagctcat tttactccac   4560

ctaatcgtta tatctggata tacccatttt ctgcatcttc tttctcaaca ataaaaaatg   4620

taactatttt gaatgcccac aaatcccatt ccagtgttac tttctgtgaa tgcagtacca   4680

tattctcatt ttcaatgaca tttcaaccac aggcagaaaa gactgtttac tccttgaccc   4740

aaagattaaa aaggattttt tattatttta aatattacac cttcagaacc ataacatgct   4800

taagaaaact ttcccaaaat gttgacctag ttaaatgagg ctatataaat ttctaatatt   4860

ttacttattc tattcaaggc atagggccaa agcattaagt ataatttaat cccatacatt   4920

cgagttaagt ttagtgttga tgttccatca ttctggacct cccaggagtt gtttaagaat   4980

gaatctctta cacctctact tttgcccctc tactgtatat taagcccata ggcttgtggg   5040

aggaaggaga atttccatta ggcaagctgt atgcagtgga attttccttt taggagacac   5100

acaattaaga ctctctggtt ctgtccttgc tttggagact ttaagacatt tcctaaagca   5160

caaataaaag cctcgtattt ccccattgag agttttgttc caaggaatat gaagtgagac   5220

atatgggtga gtcataataa tcaaaataat ttatgaagag ctgggtctgc aatagctagt   5280

ctaaaaacta cttgtgtgtc agtcctctgg ttatagtata taagagcctg aggaggtctg   5340

gcaagataga tggtgtatta tttatggatc aggctgctgc atacaaacct tgcatactat   5400

tatgcagctt acctaactct cagactattc tgagtaatgc ttgcttgcta atgaatgtat   5460

aggagaccac attgtaattg ttcttagatg atggagtcca tgcagtttct tagaaatcgg   5520

tctcagtgca tgctgtgctt tttcacattt gctctgggtt atctgggaag tatcaggttc   5580

tgggaggcaa cagcattaag tgataagaaa aggagacatt ctggcaaagc caatctgctt   5640

aaaggcaaag tccagaacct ggaacctaga ggcctttctc tctgcacgaa aaacaggtag   5700

tttgcagtct gagatatggg agagctttta ggctacacag caacccaagg gacctctcac   5760

cttttgctga gcttcaatca ggaagctatt tgcctggctc cagcagatga tgagataatg   5820

aggtagtggg ttttttatta ctgttccatt ttgcaacatc ctgcaacacc atcctgggag   5880

acaagagcat tacccagctt ggctttcacg ggggagggtt gtattcagta aaaaagaata   5940

gtaaatataa ggtcactgag attctaagta agatagtaaa tctaaggtca ctgagccaaa   6000

tccttttcaa taggcatata ttaacaggct gcttattttg gcggaggtta catatggatg   6060

aaaatgaatc ttagtcactg aatattcata tacatttccc ccaaaacctt agacattcat   6120

agtagatttt aattagttag ctttctaact agtcagattt ctgcccaaag tgcttagtca   6180

atagtaatta agatataggt aattaagata tagcttcaaa aatggctttg cttttgattt   6240

ctactcatat tcgtatggct ccagaaaaat atttttttca tatttgacaa tgtcagctcc   6300

actttagaaa ttttcaataa ccagatgaga aaaaaattaa gaaattgctc aagggaaaca   6360

tttgtaaatg gatttgaaag attgagccaa attctgttgt cagttctaag catgcagttc   6420

tcacctccat ttagtccccc atcagaacag aggtcaggaa tttagctggg gagcctaaat   6480

ttagttcagc ttacctttga gaatagcatc aattcagact ctcttttcat tatgttttct   6540

tttctttttc cctcttttta aactacattg tgttagagtc atagtctagg atcctgagag   6600

attttccatt cttgtcacca ttcacttgca ttgtaaagat tttctttgtc tgttgttggc   6660

atagattctt ttgtacatat ttatttattt gtgtttatat atgtcaattg gtttcctttc   6720

ttagcttgat attgcctagc tttgttgttt taattaactt tctattagag agactgtata   6780

tattttttct aaatactttg tgaaatcatt tttggtagca atatctttga atatgatgaa   6840

taaaagtgac tgtgagtgca aatagaatta gcagtaagaa gctactctag ctaatttgcc   6900

attttactta aatggaaaat gtttttcaaa taaatactta tgttgttc                6948


<210>  1582
<211>  1221
<212>  PRT
<213>  Homosapiens

<400>  1582

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Ala Thr Val Asn Ser 
    370                 375                 380                 


Pro Ser Thr Thr Pro Pro Thr Val Thr Thr Asn Met Pro Val Thr Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp Asn Tyr Thr Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala Asn Ile Thr Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Thr 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Thr Ser His Val 
            660                 665                 670         


Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe Phe Asn Lys Thr 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Thr Lys Val Leu 
    850                 855                 860                 


Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Thr 
    930                 935                 940                 


Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Thr Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Thr Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Thr Phe  Leu Leu Gly Met Thr  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Arg His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Thr  Ala Thr Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Thr Tyr Leu 
    1160                 1165                 1170             


Thr Ser  Lys Ser Lys Ser Ser  Ser Thr Thr Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Thr Asp Asn Val Ser  Tyr Glu His Ser Phe  Asn Lys Ser 
    1190                 1195                 1200             


Gly Ser  Leu Arg Gln Cys Phe  His Gly Gln Val Leu  Val Lys Thr 
    1205                 1210                 1215             


Gly Pro  Cys 
    1220     


<210>  1583
<211>  6902
<212>  DNA
<213>  Homosapiens

<400>  1583
ccaagtacct agggtggtgg ccgagtcccg cctcccgcca gcgggggcga ggacctgcga     60

cgcgcacccc tgcctggccc ggtctcctca gcaccagccc cacgcacacc ctacttcctc    120

agcttctcgc cctcaccctg ccaacttccc tgcgaggagg gacctgccgc cagcctgctt    180

cctcgtccgc aggccctgcg ctgaacgctg ccgcgcccag ggttcacctt gcgccgtcgg    240

gaaagcccat gaactctcca gaaacggcgt aaaggagggt cccgccgcgg cgcagggctg    300

gggcgcctgg gttccccctg ggtggagcag cggcagcaga gcgggaaagt ggtggaggat    360

gatcttgcgg ccaaagggga cctcggcgca gtaatgtcaa catgatgttt cgctcagatc    420

gaatgtggag ctgccattgg aaatggaagc ccagtcctct cctgttctta tttgctttat    480

atatcatgtg tgttcctcac tcagtgtggg gatgtgccaa ctgccgagtg gttttgtcca    540

acccttctgg gacctttact tctccatgct accctaacga ctacccaaac agccaggctt    600

gcatgtggac gctccgagcc cccaccggtt atatcattca gataacattt aacgactttg    660

acattgaaga agctcccaat tgcatttatg actcattatc ccttgataat ggagagagcc    720

agactaaatt ttgtggagca actgccaaag gcctatcatt taactcaagt gcgaatgaga    780

tgcatgtgtc cttttcaagt gactttagca tccagaagaa aggtttcaat gccagctaca    840

tcagagttgc cgtgtcctta aggaatcaaa aggtcatttt accccagaca tcagatgctt    900

accaggtatc tgttgcaaaa agcatctcta ttccagagct cagtgctttc acactctgct    960

ttgaagcaac caaagttggc catgaagaca gtgattggac agctttctcc tactcaaatg   1020

catccttcac acaattgctc agttttggaa aggccaagag tggctacttt ctatccattt   1080

ctgattcaaa atgtttgttg aataatgcat tacctgtcaa agaaaaagaa gacatttttg   1140

cagaaagctt tgaacagctc tgccttgttt ggaataattc tttgggctct attggtgtaa   1200

atttcaaaag aaactatgaa acagttccat gtgattctac cattagtaaa gttattcctg   1260

ggaatgggaa attgttgttg ggctccaatc aaaatgaaat tgtctctcta aaaggggaca   1320

tttataactt tcgactttgg aattttacca tgaatgccaa aatcctctcc aacctcagct   1380

gtaatgtgaa agggaatgta gtcgactggc aaaatgactt ctggaatatc ccaaacctag   1440

ctctgaaagc tgaaagcaac ctaagctgtg gttcctacct gatcccgctc ccagcagcag   1500

aactggccag ctgtgcagac ctggggaccc tctgtcaagc tactgtaaac tctcctagta   1560

ctacaccacc cactgtcacc actaacatgc ctgttactaa cagaatcgat aaacaaagga   1620

atgatggaat tatctataga atatccgtag tgattcagaa catccttcgt caccctgagg   1680

taaaagtaca gagcaaggtg gcagaatggc tcaattcaac cttccaaaat tggaactaca   1740

cggtttatgt cgttaatatc agttttcacc tgagtgctgg agaggacaag attaaagtca   1800

agagaagcct tgaggatgag ccaaggttgg tgctttgggc ccttctagtt tacaatgcta   1860

ccaacaatac taatttagaa ggaaaaatca ttcagcagaa gctcctaaaa aataatgagt   1920

ccttggatga aggcttgagg ctacatacag tgaatgtgag acaactgggt cattgtcttg   1980

ccatggagga acccaaaggc tactactggc catctatcca accttctgaa tacgttcttc   2040

cttgtccaga caagcctggc ttttctgctt ctcggatatg tttttacaat gctaccaacc   2100

cattggtaac ctactgggga cctgttgata tctccaactg tttaaaagaa gcaaatgaag   2160

ttgctaacca gattttaaat ttaactgctg atgggcagaa cttaacctca gccaatatta   2220

ccaacattgt ggaacaggtc aaaagaattg tgaataaaga agaaaacatt gatataacac   2280

ttggctcaac tctaatgaat atattttcta atatcttaag cagttcagac agtgacttgc   2340

ttgagtcatc ttctgaagct ttaaaaacaa ttgatgaatt ggccttcaag atagacctaa   2400

atagcacatc acatgtgaat attacaactc ggaacttggc tctcagcgta tcatccctgt   2460

taccagggac aaatgcaatt tcaaatttta gcattggtct tccaagcaat aatgaatcgt   2520

atttccagat ggattttgag agtggacaag tggatccact ggcatctgta attttgcctc   2580

caaacttact tgagaattta agtccagaag attctgtatt agttagaaga gcacagttta   2640

ctttcttcaa caaaactgga cttttccagg atgtaggacc ccaaagaaaa actttagtga   2700

gttatgtgat ggcgtgcagt attggaaaca ttactatcca gaatctgaag gatcctgttc   2760

aaataaaaat caaacataca agaactcagg aagtgcatca tcccatctgt gccttctggg   2820

atctgaacaa aaacaaaagt tttggaggat ggaacacgtc aggatgtgtt gcacacagag   2880

attcagatgc aagtgagaca gtctgcctgt gtaaccactt cacacacttt ggagttctga   2940

tggaccttcc aagaagtgcc tcacagttag atgcaagaaa cactaaagtc ctcactttca   3000

tcagctatat tgggtgtgga atatctgcta ttttttcagc agcaactctc ctgacatatg   3060

ttgcttttga gaaattgcga agggattatc cctccaaaat cttgatgaac ctgagcacag   3120

ccctgctgtt cctgaatctc ctcttcctcc tagatggctg gatcacctcc ttcaatgtgg   3180

atggactttg cattgctgtt gcagtcctgt tgcatttctt ccttctggca acctttacct   3240

ggatggggct agaagcaatt cacatgtaca ttgctctagt taaagtattt aacacttaca   3300

ttcgccgata cattctaaaa ttctgcatca ttggctgggg tttgcctgcc ttagtggtgt   3360

cagttgttct agcgagcaga aacaacaatg aagtctatgg aaaagaaagt tatgggaaag   3420

aaaaaggtga tgaattctgt tggattcaag atccagtcat attttatgtg acctgtgctg   3480

ggtattttgg agtcatgttt tttctgaaca ttgccatgtt cattgtggta atggtgcaga   3540

tctgtgggag gaatggcaag agaagcaacc ggaccctgag agaagaagtg ttaaggaacc   3600

tgcgcagtgt ggttagcttg acctttctgt tgggcatgac atggggtttt gcattctttg   3660

cctggggacc cttaaatatc cccttcatgt acctcttctc catcttcaat tcattacaag   3720

gcttatttat attcatcttc cactgtgcta tgaaggagaa tgttcagaaa cagtggcggc   3780

ggcatctctg ctgtggtaga tttcggttag cagataactc agattggagt aagacagcta   3840

ccaatatcat caagaaaagt tctgataatc taggaaaatc tttgtcttca agctccattg   3900

gttccaactc aacctatctt acatccaaat ctaaatccag ctctaccacc tatttcaaaa   3960

ggaatagcca cacagacagt gcttccatgg acaagtcctt gtcaaaactg gcccatgctg   4020

atggagatca aacatcaatc atccctgtcc atcaggtcat tgataaggtc aagggttatt   4080

gcaatgctca ttcagacaac ttctataaaa atattatcat gtcagacacc ttcagccaca   4140

gcacaaagtt ttaatgtctt taagaaaaag aaatcaatct gcagaaatgt gaagatttgc   4200

aagcagtgta aactgcaact agtgatgtaa atgtgctatt acctaggtaa ctgcatatat   4260

ataaggaatg tattttgtta agaaggcttt tgtgaaattc agaatttttc tttttaatat   4320

atttcttcca tggaagagtt gtcatcacta aaacttcagt actgagagta acatgactca   4380

gtagccacag aagctatgat ttgtaaaata tataattgaa tcagagtaat cataatgcag   4440

gggagacatt caaattagag acaagggaga agcaatgctg aggaagaccc tagatagagc   4500

tcattttact ccacctaatc gttatatctg gatataccca ttttctgcat cttctttctc   4560

aacaataaaa aatgtaacta ttttgaatgc ccacaaatcc cattccagtg ttactttctg   4620

tgaatgcagt accatattct cattttcaat gacatttcaa ccacaggcag aaaagactgt   4680

ttactccttg acccaaagat taaaaaggat tttttattat tttaaatatt acaccttcag   4740

aaccataaca tgcttaagaa aactttccca aaatgttgac ctagttaaat gaggctatat   4800

aaatttctaa tattttactt attctattca aggcataggg ccaaagcatt aagtataatt   4860

taatcccata cattcgagtt aagtttagtg ttgatgttcc atcattctgg acctcccagg   4920

agttgtttaa gaatgaatct cttacacctc tacttttgcc cctctactgt atattaagcc   4980

cataggcttg tgggaggaag gagaatttcc attaggcaag ctgtatgcag tggaattttc   5040

cttttaggag acacacaatt aagactctct ggttctgtcc ttgctttgga gactttaaga   5100

catttcctaa agcacaaata aaagcctcgt atttccccat tgagagtttt gttccaagga   5160

atatgaagtg agacatatgg gtgagtcata ataatcaaaa taatttatga agagctgggt   5220

ctgcaatagc tagtctaaaa actacttgtg tgtcagtcct ctggttatag tatataagag   5280

cctgaggagg tctggcaaga tagatggtgt attatttatg gatcaggctg ctgcatacaa   5340

accttgcata ctattatgca gcttacctaa ctctcagact attctgagta atgcttgctt   5400

gctaatgaat gtataggaga ccacattgta attgttctta gatgatggag tccatgcagt   5460

ttcttagaaa tcggtctcag tgcatgctgt gctttttcac atttgctctg ggttatctgg   5520

gaagtatcag gttctgggag gcaacagcat taagtgataa gaaaaggaga cattctggca   5580

aagccaatct gcttaaaggc aaagtccaga acctggaacc tagaggcctt tctctctgca   5640

cgaaaaacag gtagtttgca gtctgagata tgggagagct tttaggctac acagcaaccc   5700

aagggacctc tcaccttttg ctgagcttca atcaggaagc tatttgcctg gctccagcag   5760

atgatgagat aatgaggtag tgggtttttt attactgttc cattttgcaa catcctgcaa   5820

caccatcctg ggagacaaga gcattaccca gcttggcttt cacgggggag ggttgtattc   5880

agtaaaaaag aatagtaaat ataaggtcac tgagattcta agtaagatag taaatctaag   5940

gtcactgagc caaatccttt tcaataggca tatattaaca ggctgcttat tttggcggag   6000

gttacatatg gatgaaaatg aatcttagtc actgaatatt catatacatt tcccccaaaa   6060

ccttagacat tcatagtaga ttttaattag ttagctttct aactagtcag atttctgccc   6120

aaagtgctta gtcaatagta attaagatat aggtaattaa gatatagctt caaaaatggc   6180

tttgcttttg atttctactc atattcgtat ggctccagaa aaatattttt ttcatatttg   6240

acaatgtcag ctccacttta gaaattttca ataaccagat gagaaaaaaa ttaagaaatt   6300

gctcaaggga aacatttgta aatggatttg aaagattgag ccaaattctg ttgtcagttc   6360

taagcatgca gttctcacct ccatttagtc ccccatcaga acagaggtca ggaatttagc   6420

tggggagcct aaatttagtt cagcttacct ttgagaatag catcaattca gactctcttt   6480

tcattatgtt ttcttttctt tttccctctt tttaaactac attgtgttag agtcatagtc   6540

taggatcctg agagattttc cattcttgtc accattcact tgcattgtaa agattttctt   6600

tgtctgttgt tggcatagat tcttttgtac atatttattt atttgtgttt atatatgtca   6660

attggtttcc tttcttagct tgatattgcc tagctttgtt gttttaatta actttctatt   6720

agagagactg tatatatttt ttctaaatac tttgtgaaat catttttggt agcaatatct   6780

ttgaatatga tgaataaaag tgactgtgag tgcaaataga attagcagta agaagctact   6840

ctagctaatt tgccatttta cttaaatgga aaatgttttt caaataaata cttatgttgt   6900

tc                                                                  6902


<210>  1584
<211>  1250
<212>  PRT
<213>  Homosapiens

<400>  1584

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Ala Thr Val Asn Ser 
    370                 375                 380                 


Pro Ser Thr Thr Pro Pro Thr Val Thr Thr Asn Met Pro Val Thr Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp Asn Tyr Thr Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala Asn Ile Thr Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Thr 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Thr Ser His Val 
            660                 665                 670         


Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe Phe Asn Lys Thr 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Thr Lys Val Leu 
    850                 855                 860                 


Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Thr 
    930                 935                 940                 


Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Thr Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Thr Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Thr Phe  Leu Leu Gly Met Thr  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Arg His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Thr  Ala Thr Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Thr Tyr Leu 
    1160                 1165                 1170             


Thr Ser  Lys Ser Lys Ser Ser  Ser Thr Thr Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Thr Asp Ser Ala Ser  Met Asp Lys Ser Leu  Ser Lys Leu 
    1190                 1195                 1200             


Ala His  Ala Asp Gly Asp Gln  Thr Ser Ile Ile Pro  Val His Gln 
    1205                 1210                 1215             


Val Ile  Asp Lys Val Lys Gly  Tyr Cys Asn Ala His  Ser Asp Asn 
    1220                 1225                 1230             


Phe Tyr  Lys Asn Ile Ile Met  Ser Asp Thr Phe Ser  His Ser Thr 
    1235                 1240                 1245             


Lys Phe  
    1250 


<210>  1585
<211>  2293
<212>  DNA
<213>  Homosapiens

<400>  1585
tacatgatgt aagtgctgct gaagccctgc tgagtcagag tccacaaatc aaacagcccc     60

tagaaacctg cccttctctg gcagggttag ggctgagact gggccctcag accatttgga    120

atgaccagtg atttcagctc tcactccctt ctcatcagca cgtgtctaca gttgcaagtt    180

ctcactctgt agcccagtct ggagtgcagt ggtacaataa tggctcactt cagctttgac    240

cttccaggct caagcggtcc ttctacctca gcctctggag caactggaac cacgggtgca    300

ccccaccacg cccagctaac ttttgtattt ttttgtagag acagggtttt gccatgttgc    360

tcagtcccaa tatcatcacc agatgagaat atgtatggat tcatgaacaa gaaaattgct    420

taaccatttg atcaagagag attggaaaat caagatgaag caggtctggg tgaaagagct    480

gtgaatggat taatggaaca gaaaggaggt gtggagatcc ttctattaca tgttaatgat    540

caccagggaa catccactac aatagaacat cccactaaat caccagtaga cacaagagaa    600

tatgtggcca gttgactttg gccagcctct gtcattagat gtcaatgttc aaacaacggt    660

acatgaatgg catagccctg gtagcaggag tgggggctat gcatggatcc agcaatacac    720

actcccactc cacaacattg acccagccac caaggctgac aaaatattca accttccagc    780

aacagaaacc aaggatgacc cttatccctg cccaggtatg gtattagccc ttgagactaa    840

ccagccatgt ggtgggaagt tgaatatctt ctaccctgga aaggtcattg attcatttta    900

gtatgaatta attcatgttt ctgggttgga tttgctgttc ttgcctgcag ggcctcagct    960

ggcaccagca tctaaaggct tagagagtta gtgatccacc aacatggcat ctcacataac   1020

atcccatcaa accaagtgac ccactttact agaaatgagg tgcacgagtg gacaagctcc   1080

agcttgaccc aagtggaaca agctctacta gtcccatcag atcatgcacc atccagaagc   1140

tgccacacta acagagtgat ggaaaggcct gttgaaggca tagtggatga gccacaccat   1200

tgcaaggtaa tgtcatcgga ggtttattta gcatgtgtat tacacccaga agaatggtgt   1260

cccatccttg caaggtaatg tcatcatcag attctcctgg gtgtaatata catgctaaac   1320

aaacaatcat tatatgatgc tgtgtcccca agaggtaaaa tatgtgggag ctaaggagtg   1380

gaagcagcaa tagcctcact taccatcaat acaattgact ccttagggaa cttgtgccta   1440

ggctctgtgg gtttagaggt cctggtgccc aaaggagatg tgcttccatc agggaataca   1500

acaagcattc aattgaacat gaggttaagg ctgccacttg ggagcatcag gctcctcatg   1560

ccaagagatc accaagcaaa aagaggaatc accgtaccat gagcattaat caatcccatt   1620

cttcagaagg agatgggact gctgacacaa ggccacagag aggcccccag ataacttgcc   1680

tgggtgtccc ttagaattcc cttgcccatt ttttaataat agatggataa atgcaacagt   1740

ctccacctaa caaaggcata atgatgggac ttctcaagag tgagaagcta ggtcattcca   1800

ccagccaagt agaccagcag aggtaccaaa aagagacagg aaatctagac tgtaaagtaa   1860

aacaggaaga ttccccagga acagaagcca actgtgatcc tagaggagct tctccttaac   1920

atgcagaaag aagtggatcc atgaagcaca agagctgagc tgtcatggaa actgcacatc   1980

tcaaatttcc catcaggact gaaggaccta gtcccccaca ggctgaagac agtcacctta   2040

cccaacttca tgctctcttc caggggcagc ctgcatccaa caacttgtca gcacaggact   2100

ataaaggcct taccctttgc ctctgtgaag catcccacag agaggtgcat ccacctctga   2160

aggtacatcc cagcttcagg ctcccagtca ctttgggctt acccagcctc ttcgtctgcc   2220

ctgcttttct ccctcccctt ccttcctgca ggtttggatc ctgagagcac tccctaataa   2280

acctcatgcc cac                                                      2293


<210>  1586
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  1586

Met Trp Pro Val Asp Phe Gly Gln Pro Leu Ser Leu Asp Val Asn Val 
1               5                   10                  15      


Gln Thr Thr Val His Glu Trp His Ser Pro Gly Ser Arg Ser Gly Gly 
            20                  25                  30          


Tyr Ala Trp Ile Gln Gln Tyr Thr Leu Pro Leu His Asn Ile Asp Pro 
        35                  40                  45              


Ala Thr Lys Ala Asp Lys Ile Phe Asn Leu Pro Ala Thr Glu Thr Lys 
    50                  55                  60                  


Asp Asp Pro Tyr Pro Cys Pro Gly Met Val Leu Ala Leu Glu Thr Asn 
65                  70                  75                  80  


Gln Pro Cys Gly Gly Lys Leu Asn Ile Phe Tyr Pro Gly Lys Val Ile 
                85                  90                  95      


Asp Ser Phe 
            


<210>  1587
<211>  5018
<212>  DNA
<213>  Homosapiens

<400>  1587
gcggatcccc gaactgcgcg gcccgactcg agtccgccat attggatgcc gcagccgctg     60

ctgccagcgc ttcctcctct gtcttcgccg agcggggctg gttcctgcgg cccgagcggc    120

ggggaggtga aacaggagcc cgtcggagga aggggcagaa gggagtggag agtgtagggg    180

aaggggctag agggaggggg accgaaacgg agcggggcag agaagagaag gcgccgcggc    240

ccagcccctc ccccgcccgc cgccgacccg ccccggcagc gcctctgttc cctagaacgg    300

cgctcccccc gccctagcgg ccatgccggt gccgctctgc cgctgaggga gcccttcccc    360

gccagcgcgt gcccttccac tccgccccga ggtcgcagcg gcccgctctc ccgccagcgc    420

cccctcctcg cggccacgca gcagcccgcg tctcgctctc cccacccagt gcagtggccg    480

ccgcctcttc cgccgccggg ctcggggcct ccgcagcgac aacatggagg ccgtgaagac    540

cttcaatagc gagttgtatt ccctgaatga ctataaacca cccatttcga aagcgaaaat    600

gacccaaatt actaaggcag ccatcaaagc tattaagttc tataaacatg tggtacagag    660

tgttgagaag tttattcaga aatgtaaacc agaatacaaa gtacctggac tttatgttat    720

tgactccatt gtgcgacaat cccgacatca gtttggtcaa gaaaaggatg tgtttgcacc    780

cagatttagt aataacatca ttagcacttt ccagaattta tatcgttgcc ctggggatga    840

caagagtaaa atagtgagag tactaaactt atggcagaag aataatgtat ttaagagtga    900

gattattcag ccccttttgg atatggcagc cgggattccg cctccagttg tcacacctgt    960

tttggccagc actaccactg ctatgagcaa tactccagga actcctgtga cacctgttac   1020

tccggccaat gtggtccaag gcttacctga tccgtgggta tctcagataa caaatacaga   1080

tacacttgcg gctgtagctc agatcttgca aagtcctcaa ggccagcagc ttcaacaatt   1140

aatacaaacc ttacagatac aacaacagaa gccccagcct tccattctgc aggccctaga   1200

tgctggtctt gttgttcagt tgcaagctct tacggcacaa cttacagctg cagctgcagc   1260

tgccaacact cttactccct tagaacaggg agtctccttt aacaagaagt tgatggatag   1320

gtttgatttt ggggaagact ctgagcatag tgaagaaccc aaaaaggaaa ttccagcttc   1380

acaactttct cacgtttcag aatctgtgaa caattccatt tttcatcaga tagcagaaca   1440

actacaacag caaaacctag aacatctcag acagcagctc ttggagcagc aacagcctca   1500

aaaggccact cctcaggata gtcaggaagg aacctttggg tcagagcatt cagcgtcacc   1560

atcacaaggg agtagtcagc agcattttct tgaacctgaa gtcaatttgg atgattccat   1620

agatattcag caacaggata tggatataga tgaagggcaa gatggagtgg aagaggaggt   1680

ctttgaacaa gaagctaaga aagtggcggt tcgctcaaga tcaagaacac attcacgatc   1740

tcgttcaaga tcaccaagaa aacgaaggtc taggtcacgg tctggctcta gaaagcgtaa   1800

acacagaaag cgatcacgct cccgctcaag agaaagaaag aggaaatcat cacggtcgta   1860

ttcaagtgaa aggagagcca gagaaaggga gaaagaacga cagaaaaagg gattacctcc   1920

aattagatct aaaacactaa gtgtatgtag tactactctc tgggttgggc aagtggacaa   1980

gaaggcaaca cagcaagact taaccaacct gtttgaagag tttggacaga ttgaatccat   2040

taatatgatt cctccccggg gctgtgctta tgtctgcatg gttcatcgac aagatgcatt   2100

tcgagctctt cagaaactca gttctggatc atataaaatt gggtccaagg tcattaagat   2160

cgcttgggct ttaaacaaag gtgtaaaaac agaatacaaa caattctggg atgtggatct   2220

tggagttaca tatataccat gggaaaaagt taaagtggat gacttggaag gttttgcaga   2280

aggaggcatg attgatcagg agactgtaaa tactgagtgg gaaactgtga aaagctcaga   2340

acctgttaaa gagacggtcc agacaactca gagcccaact ccagttgaaa aggagacagt   2400

ggtcacaacc caggcagagg ttttccctcc tcctgttgct atgttgcaga ttccagtggc   2460

gccagccgtg cctacagtta gtttagtccc accagcattt cctgtgtcga tgccggttcc   2520

tcctcctgga ttcagtccaa tccctccacc tcctttttta agagcaagtt ttaacccttc   2580

acaaccacca cctggtttca tgccgcctcc agttccccca cctgttgtgc caccccctac   2640

gattccacca gtagtaccaa catctttagt gcagccgtca ttatccatga caccggaaac   2700

tgtgaaagat gttggatttg gtagccttgt tataccaggc ggttctgttg ccagcaatct   2760

tgctacttcc gctctgccag ctggaaatgt ttttaatgct ccaactaaac aggcagagcc   2820

tgaagaaaaa gtacctcatc ttatagacca ccagatttct tctggtgaaa acaccagatc   2880

agtgattcca aatgatattt caagtaatgc tgcaatttta ggaggacagc cgccaaatgt   2940

gacaagcaat tctggaattc tgggagtcca aagaccaaat gtatcaagta attctgaaat   3000

tcttggggtc cggccatcta atgtttccag tagttctggg attattgcag cccaaccacc   3060

aaatattcta aataactctg gaatattggg aatacagcca cccagtgtgt caaatagttc   3120

tggacttttg ggagtgctac ccccaaatat acctaacaat tctggacttg taggagtaca   3180

gccaccaaat gttccaaata ctcctggact tctgggaaca cagccaccag ctggacctca   3240

aaacttaccc cctttaagta tccctaatca aaggatgccc acaatgccaa tgttagacat   3300

tcgtccggga ctaataccac aggcacctgg gccaagattc cctttaatac agcctggaat   3360

tccaccccaa cggggaatcc cacccccatc ggtacttgat tcagctcttc atccaccacc   3420

ccgtggacct tttcctccag gagatatttt tagtcaacca gaaagacctt ttttagctcc   3480

tggaagacaa agcgtagaca atgttactaa cccagaaaaa aggataccac ttgggaatga   3540

taacattcaa caggaaggag atagagatta ccggtttcct cctatagaaa ccagggaaag   3600

cattagtaga cctccccctg tggatgttag agatgtggtt gggcggccta tagatccaag   3660

agaaggtcct ggacggcctc cactagatgg tagggatcat tttggaagac ctcctgtaga   3720

tataagagag aatcttgtga ggccaggtat agatcatctt ggtcgaagag accactttgg   3780

ctttaatcca gagaagccct gggggcatag aggagatttt gatgagagag agcatcgggt   3840

tctaccggtc tatggtggtc caaaaggctt acatgaagaa agaggtagat ttcggtctgg   3900

aaactatcga tttgatccta gaagtggtcc ttggaaccga ggatttggac aagaagttca   3960

cagagatttt gatgaccgca gaagaccctg ggagaggcaa agggataggg atgacagaga   4020

ttttgatttc tgcagagaaa tgaatggaaa tcgtcttgga cgagacagaa ttcaaaacac   4080

ttgggttccc cctcctcatg ctcgggtttt tgattatttt gaaggggcca cttctcaacg   4140

aaaaggtgat aatgtgcctc aggttaatgg tgaaaataca gagagacatg ctcagccacc   4200

acctatacca gtacagaatg atcctgaact ttatgaaaaa ctgacatctt caaatgaaat   4260

aaacaaggag aagagtgaca cagttgctga tatagaaagt gaaccagtgg tagaaagcac   4320

agaaactgag gggacataat catcactcag taggtaaaag ataccttttg taaagttgtc   4380

atctctctgt aatagataat ggctgactgg accatagttg ttcacttttg tctgccagaa   4440

ttaagttaat ctgatgttca tgttcacctt tctcttaaaa taattgtaca actgacttgt   4500

atagacattg ttcttaatat gaacatggta ggtaaacttt ttttttattt ttttctgata   4560

aaatacaaat gttggcccca gattctttta acgtcaagga aatgaataac agcttgtcag   4620

agacttccta tggaagaaag aattttttag atactatcat taggttggat atggtaatag   4680

atatatttca gaatagcaag tggtggtata tcttatccat atctttaggc tgctgcagaa   4740

ttttaaggtt atagataaag ctgtgatatt ttatgcaaag actggctcta ggtatttgag   4800

gagcacaata cagagatttt aaaaagtgat tttgtaaaat ctacactacg gtctctgttt   4860

ctccaaagta agtgtttgtg atttgttcct catactgcag tgagtaaaaa agaaacaaga   4920

aaacaacaac ataaatatta aagtacgttt caatgttggg tgaattttgt ttttagatgc   4980

caataaaact tatttgtttg ataaaaaaaa aaaaaaaa                           5018


<210>  1588
<211>  1271
<212>  PRT
<213>  Homosapiens

<400>  1588

Met Glu Ala Val Lys Thr Phe Asn Ser Glu Leu Tyr Ser Leu Asn Asp 
1               5                   10                  15      


Tyr Lys Pro Pro Ile Ser Lys Ala Lys Met Thr Gln Ile Thr Lys Ala 
            20                  25                  30          


Ala Ile Lys Ala Ile Lys Phe Tyr Lys His Val Val Gln Ser Val Glu 
        35                  40                  45              


Lys Phe Ile Gln Lys Cys Lys Pro Glu Tyr Lys Val Pro Gly Leu Tyr 
    50                  55                  60                  


Val Ile Asp Ser Ile Val Arg Gln Ser Arg His Gln Phe Gly Gln Glu 
65                  70                  75                  80  


Lys Asp Val Phe Ala Pro Arg Phe Ser Asn Asn Ile Ile Ser Thr Phe 
                85                  90                  95      


Gln Asn Leu Tyr Arg Cys Pro Gly Asp Asp Lys Ser Lys Ile Val Arg 
            100                 105                 110         


Val Leu Asn Leu Trp Gln Lys Asn Asn Val Phe Lys Ser Glu Ile Ile 
        115                 120                 125             


Gln Pro Leu Leu Asp Met Ala Ala Gly Ile Pro Pro Pro Val Val Thr 
    130                 135                 140                 


Pro Val Leu Ala Ser Thr Thr Thr Ala Met Ser Asn Thr Pro Gly Thr 
145                 150                 155                 160 


Pro Val Thr Pro Val Thr Pro Ala Asn Val Val Gln Gly Leu Pro Asp 
                165                 170                 175     


Pro Trp Val Ser Gln Ile Thr Asn Thr Asp Thr Leu Ala Ala Val Ala 
            180                 185                 190         


Gln Ile Leu Gln Ser Pro Gln Gly Gln Gln Leu Gln Gln Leu Ile Gln 
        195                 200                 205             


Thr Leu Gln Ile Gln Gln Gln Lys Pro Gln Pro Ser Ile Leu Gln Ala 
    210                 215                 220                 


Leu Asp Ala Gly Leu Val Val Gln Leu Gln Ala Leu Thr Ala Gln Leu 
225                 230                 235                 240 


Thr Ala Ala Ala Ala Ala Ala Asn Thr Leu Thr Pro Leu Glu Gln Gly 
                245                 250                 255     


Val Ser Phe Asn Lys Lys Leu Met Asp Arg Phe Asp Phe Gly Glu Asp 
            260                 265                 270         


Ser Glu His Ser Glu Glu Pro Lys Lys Glu Ile Pro Ala Ser Gln Leu 
        275                 280                 285             


Ser His Val Ser Glu Ser Val Asn Asn Ser Ile Phe His Gln Ile Ala 
    290                 295                 300                 


Glu Gln Leu Gln Gln Gln Asn Leu Glu His Leu Arg Gln Gln Leu Leu 
305                 310                 315                 320 


Glu Gln Gln Gln Pro Gln Lys Ala Thr Pro Gln Asp Ser Gln Glu Gly 
                325                 330                 335     


Thr Phe Gly Ser Glu His Ser Ala Ser Pro Ser Gln Gly Ser Ser Gln 
            340                 345                 350         


Gln His Phe Leu Glu Pro Glu Val Asn Leu Asp Asp Ser Ile Asp Ile 
        355                 360                 365             


Gln Gln Gln Asp Met Asp Ile Asp Glu Gly Gln Asp Gly Val Glu Glu 
    370                 375                 380                 


Glu Val Phe Glu Gln Glu Ala Lys Lys Val Ala Val Arg Ser Arg Ser 
385                 390                 395                 400 


Arg Thr His Ser Arg Ser Arg Ser Arg Ser Pro Arg Lys Arg Arg Ser 
                405                 410                 415     


Arg Ser Arg Ser Gly Ser Arg Lys Arg Lys His Arg Lys Arg Ser Arg 
            420                 425                 430         


Ser Arg Ser Arg Glu Arg Lys Arg Lys Ser Ser Arg Ser Tyr Ser Ser 
        435                 440                 445             


Glu Arg Arg Ala Arg Glu Arg Glu Lys Glu Arg Gln Lys Lys Gly Leu 
    450                 455                 460                 


Pro Pro Ile Arg Ser Lys Thr Leu Ser Val Cys Ser Thr Thr Leu Trp 
465                 470                 475                 480 


Val Gly Gln Val Asp Lys Lys Ala Thr Gln Gln Asp Leu Thr Asn Leu 
                485                 490                 495     


Phe Glu Glu Phe Gly Gln Ile Glu Ser Ile Asn Met Ile Pro Pro Arg 
            500                 505                 510         


Gly Cys Ala Tyr Val Cys Met Val His Arg Gln Asp Ala Phe Arg Ala 
        515                 520                 525             


Leu Gln Lys Leu Ser Ser Gly Ser Tyr Lys Ile Gly Ser Lys Val Ile 
    530                 535                 540                 


Lys Ile Ala Trp Ala Leu Asn Lys Gly Val Lys Thr Glu Tyr Lys Gln 
545                 550                 555                 560 


Phe Trp Asp Val Asp Leu Gly Val Thr Tyr Ile Pro Trp Glu Lys Val 
                565                 570                 575     


Lys Val Asp Asp Leu Glu Gly Phe Ala Glu Gly Gly Met Ile Asp Gln 
            580                 585                 590         


Glu Thr Val Asn Thr Glu Trp Glu Thr Val Lys Ser Ser Glu Pro Val 
        595                 600                 605             


Lys Glu Thr Val Gln Thr Thr Gln Ser Pro Thr Pro Val Glu Lys Glu 
    610                 615                 620                 


Thr Val Val Thr Thr Gln Ala Glu Val Phe Pro Pro Pro Val Ala Met 
625                 630                 635                 640 


Leu Gln Ile Pro Val Ala Pro Ala Val Pro Thr Val Ser Leu Val Pro 
                645                 650                 655     


Pro Ala Phe Pro Val Ser Met Pro Val Pro Pro Pro Gly Phe Ser Pro 
            660                 665                 670         


Ile Pro Pro Pro Pro Phe Leu Arg Ala Ser Phe Asn Pro Ser Gln Pro 
        675                 680                 685             


Pro Pro Gly Phe Met Pro Pro Pro Val Pro Pro Pro Val Val Pro Pro 
    690                 695                 700                 


Pro Thr Ile Pro Pro Val Val Pro Thr Ser Leu Val Gln Pro Ser Leu 
705                 710                 715                 720 


Ser Met Thr Pro Glu Thr Val Lys Asp Val Gly Phe Gly Ser Leu Val 
                725                 730                 735     


Ile Pro Gly Gly Ser Val Ala Ser Asn Leu Ala Thr Ser Ala Leu Pro 
            740                 745                 750         


Ala Gly Asn Val Phe Asn Ala Pro Thr Lys Gln Ala Glu Pro Glu Glu 
        755                 760                 765             


Lys Val Pro His Leu Ile Asp His Gln Ile Ser Ser Gly Glu Asn Thr 
    770                 775                 780                 


Arg Ser Val Ile Pro Asn Asp Ile Ser Ser Asn Ala Ala Ile Leu Gly 
785                 790                 795                 800 


Gly Gln Pro Pro Asn Val Thr Ser Asn Ser Gly Ile Leu Gly Val Gln 
                805                 810                 815     


Arg Pro Asn Val Ser Ser Asn Ser Glu Ile Leu Gly Val Arg Pro Ser 
            820                 825                 830         


Asn Val Ser Ser Ser Ser Gly Ile Ile Ala Ala Gln Pro Pro Asn Ile 
        835                 840                 845             


Leu Asn Asn Ser Gly Ile Leu Gly Ile Gln Pro Pro Ser Val Ser Asn 
    850                 855                 860                 


Ser Ser Gly Leu Leu Gly Val Leu Pro Pro Asn Ile Pro Asn Asn Ser 
865                 870                 875                 880 


Gly Leu Val Gly Val Gln Pro Pro Asn Val Pro Asn Thr Pro Gly Leu 
                885                 890                 895     


Leu Gly Thr Gln Pro Pro Ala Gly Pro Gln Asn Leu Pro Pro Leu Ser 
            900                 905                 910         


Ile Pro Asn Gln Arg Met Pro Thr Met Pro Met Leu Asp Ile Arg Pro 
        915                 920                 925             


Gly Leu Ile Pro Gln Ala Pro Gly Pro Arg Phe Pro Leu Ile Gln Pro 
    930                 935                 940                 


Gly Ile Pro Pro Gln Arg Gly Ile Pro Pro Pro Ser Val Leu Asp Ser 
945                 950                 955                 960 


Ala Leu His Pro Pro Pro Arg Gly Pro Phe Pro Pro Gly Asp Ile Phe 
                965                 970                 975     


Ser Gln Pro Glu Arg Pro Phe Leu Ala Pro Gly Arg Gln Ser Val Asp 
            980                 985                 990         


Asn Val Thr Asn Pro Glu Lys Arg  Ile Pro Leu Gly Asn  Asp Asn Ile 
        995                 1000                 1005             


Gln Gln  Glu Gly Asp Arg Asp  Tyr Arg Phe Pro Pro  Ile Glu Thr 
    1010                 1015                 1020             


Arg Glu  Ser Ile Ser Arg Pro  Pro Pro Val Asp Val  Arg Asp Val 
    1025                 1030                 1035             


Val Gly  Arg Pro Ile Asp Pro  Arg Glu Gly Pro Gly  Arg Pro Pro 
    1040                 1045                 1050             


Leu Asp  Gly Arg Asp His Phe  Gly Arg Pro Pro Val  Asp Ile Arg 
    1055                 1060                 1065             


Glu Asn  Leu Val Arg Pro Gly  Ile Asp His Leu Gly  Arg Arg Asp 
    1070                 1075                 1080             


His Phe  Gly Phe Asn Pro Glu  Lys Pro Trp Gly His  Arg Gly Asp 
    1085                 1090                 1095             


Phe Asp  Glu Arg Glu His Arg  Val Leu Pro Val Tyr  Gly Gly Pro 
    1100                 1105                 1110             


Lys Gly  Leu His Glu Glu Arg  Gly Arg Phe Arg Ser  Gly Asn Tyr 
    1115                 1120                 1125             


Arg Phe  Asp Pro Arg Ser Gly  Pro Trp Asn Arg Gly  Phe Gly Gln 
    1130                 1135                 1140             


Glu Val  His Arg Asp Phe Asp  Asp Arg Arg Arg Pro  Trp Glu Arg 
    1145                 1150                 1155             


Gln Arg  Asp Arg Asp Asp Arg  Asp Phe Asp Phe Cys  Arg Glu Met 
    1160                 1165                 1170             


Asn Gly  Asn Arg Leu Gly Arg  Asp Arg Ile Gln Asn  Thr Trp Val 
    1175                 1180                 1185             


Pro Pro  Pro His Ala Arg Val  Phe Asp Tyr Phe Glu  Gly Ala Thr 
    1190                 1195                 1200             


Ser Gln  Arg Lys Gly Asp Asn  Val Pro Gln Val Asn  Gly Glu Asn 
    1205                 1210                 1215             


Thr Glu  Arg His Ala Gln Pro  Pro Pro Ile Pro Val  Gln Asn Asp 
    1220                 1225                 1230             


Pro Glu  Leu Tyr Glu Lys Leu  Thr Ser Ser Asn Glu  Ile Asn Lys 
    1235                 1240                 1245             


Glu Lys  Ser Asp Thr Val Ala  Asp Ile Glu Ser Glu  Pro Val Val 
    1250                 1255                 1260             


Glu Ser  Thr Glu Thr Glu Gly  Thr 
    1265                 1270     


<210>  1589
<211>  6657
<212>  DNA
<213>  Homosapiens

<400>  1589
atggcctcga atgggggctt caggacttta gtgctttatt ttactgtggc taagctggtg     60

ttcaagttgc aagataaagt cctctttaag tcctctttac tctttcctct cctcttggaa    120

ttgcgagctg tgctgcctgg ggttggggga caggccttgg ccatgtcagc tagtgtttca    180

ctgggttgca tgcacaccaa gcctactggc tccaaggtcg gcccagtact gcgacttgcc    240

caggaattgt ggtccttgtg gcctaaactg tctttcaagt ttatttagta ccccagagca    300

cttgagcctg cagtggcagg gcttgctaga actccggttc tgactaccaa gacgaaccct    360

tctcctccag ctaggactgg tctaaatgct ccctccatgg gcaccagcct aattctgccc    420

tgtgttgctt tccactgtat cagggcagca ctgagttgca atgcaaagct ccataatgac    480

ttccctctcc ctcttccaaa gacacagatt ctctgcatca tgctgcgctc ctaggggaag    540

ggcgaagggt agtgtgagca attcaaggct gtctttccca ccctcttcag tgcctcttcc    600

ttgatatgat gttaaaacca ggtactgtga ttgctcacct tattttctgg ttcttttgaa    660

ggtgctgtct tctgtggata atagttcaat ttggtgttct tgaggggtga ggttggaggg    720

gacagggtgg gatgatagct ggagggttct gtttggccat cttgctctct ttatagttat    780

tcttcattaa atagaatcac caaggcagga aggtgtcatt actgctttga ttccagatgc    840

ctctaggctc gtaggccatt tgaaggcttc caaagctctg gcgatagaat agattccttc    900

atggaccccc attcctactc ctctacagta tccatgccac gtgaagatag cagtaggaga    960

agattcctcc agcttcctcc agagtgtgaa gggggtgctg aggatggagc ttctgagcct   1020

gaatctctgc cgactcagga gacgtcagag tctgtgttcc gtgactggct ccccagcaat   1080

ctcaccagat gtgcttagat ttgggtggac tcagtcacgc tgcccaaagc tgcattcact   1140

catagggaga gcaagggacc cacagtactg ctgccatgtc cctttgaggt ggcctctgtg   1200

tgcacctgct ggtcctccag cccagtctgc tctctgtaca caatccccat gagcagcatg   1260

agtgccaaga actgctcagt gctcaggtct ggcacctggg cttctttcac gtgctcataa   1320

ggcagccagc gtgtttccct aggtaccccg gaggctttgg gcacagagga ccacacgtcc   1380

agaagtttgg gccattcaca tgtgtgccat gtggacctct ctggagaaga gagctgggtg   1440

cacatctcag cgtgtgcaat gggcatgagt gtgtttggca agcatgctca ggatgaagat   1500

caccccctcc tttatcccac tgcttcctgt agcttccaaa ccacctcctc agaagtgtca   1560

tctccagcca ctgcttcctg tagcttccaa acagcctcct cagaagtgtc acctccagcc   1620

actgcttcct gtagcttcca aacggcctcc tcagaagtgt cacctccagc cactgcttcc   1680

tgtagcttcc aaacggcctc ctcagaagtg tcacctccag ccactgcttc ctgtagcttc   1740

caaacggcct cctcagaagt gtcacctgca gccactgctt cctgctcttt cacattttct   1800

ttcttctttg tctgtgctct gtggtttggc atctgcccca gctgctctgc tgccgtcttg   1860

tctaccatcc atgcatgaat gacttcctta aaaacaccgc cttgtctttc cgtggtcctt   1920

ctccttttcc ttccttccaa agttgtcacc gtggacctcc tcttccaccc ccgttcagga   1980

aactgttccc tcaggctcac ctgacctagc cctttccagt ttccttagca cctgggcagg   2040

tccttccggg tgactcatcc catcctagca agcagatttt ggggacatac ctaagagctc   2100

tcccctgttc ttctggtgaa gcattttctc ttttcagaga agtcactgca agccagggtg   2160

acttgctgat ttgaatcttc agccctgact cctcttctga gttataatta ctgcctggac   2220

attgcaccct gggggatcta ttcagactga acatgaccaa cggtgaactt gtctccccca   2280

ccttctgtcc tgccccaaat cctcacccta gtatctgtta ggagggcacc tctttcagcc   2340

ctccaacctc tagagccaac tttgaccctt ccatatcctt cttcccctgg aaagggacac   2400

caagttctgc ttttccttga aaatccttta gatttgcctc tagtctctgt ccttgtgacc   2460

tctggcaata gcttctgctc tgggctcccg ctccagtgcc ccatttctgg acttcaacac   2520

aatttgtttt cttttctttt cctttttttt gagaccaagt ctcactctgt cacccaggct   2580

ggagtgcagt ggtgcgatct cggctcactg caacctccgc ctcctaggtt taagggattc   2640

tcctgcctca gcctgggact acaggcttgt gccaccacgc ccggctcatt tttgtatctt   2700

ttagtggaga tggggtttca ccatattggc caggctggtc ttgaactcct gacctcgtga   2760

tccacccacc tcagcctccc aaagtgctgg gattacaggc atgagccacc acacccacca   2820

catcaccctc tgctcaaaaa ccttaagtgg ctccttctgg cccaggatgg gtcaagtcca   2880

ggttctaaat ccccatgtaa cctggcacca acctacccat gtccaaccat atttcccaca   2940

ccctccccag acattcatgg aacagctctt caaggcactg gcccaggttc taggggaatc   3000

aaggaggagg aagcctggtc ttctccttca agaccttttc agtgaggtgg aagctggagg   3060

tggggcatgt agctaggcac aggaactcta atgacgatgt aagtggcatt gtcacaggca   3120

ggtcatgtga cacgggagca cagagaagag taccattagg tcagacatat catacatgtg   3180

gcttgtgaca tcctatcaac atgaaacata gctgtgtttc ttaagccatt ttgttcacaa   3240

cacagccaat gaattcttgt gacaatgtac caaattattc aaaacaaatt ttttagtaaa   3300

ataataaaac tacttttctc aaaacagttt gatttatttt cttttttctt ttttcttttt   3360

ttttgagatg gagtctcact ttgtcaccca ggttggagtg cagtggtgcg atctcagctc   3420

actgcaatct gcctcccagg ttcaagcgat tctcttgcct cagccacccg agtagctggg   3480

attacaggca cacaccacca tgcctggcta atttttgtat ttttaatacg gatggggttt   3540

caccatgctg gccaggctgg tctcaaactc ctggcctcag gtgatccacc aaagtgctgg   3600

gattacaggc atgagccacc gcacccagcc tcaaaacagt ttgatttttg aggaaagagt   3660

gcctcctttt cattaatttg cgggggtggg gggtaacaat ttgcctgaat ttctatattt   3720

ttgaaaaagc tcttttaaaa catcttgtta gatggggcac catgactcat gcctgtaatc   3780

gcaacacttt gggaggccaa cgccggaggg ctgcttgagc tcaggagttc aagaccagcc   3840

tgggcaacaa agcaagacct tgtctctgct aaaaataaga aaaattagct gggcgtgacg   3900

gtgcgtgcct gtggtcccag ctacttggag gctgagggtg ggaggatcgc ttgagcccag   3960

gagatcgagg ttggagtgag ctatgatagc gccactgcac tccacagtgg gcaacagagc   4020

aagattctgt cttaaaaaac aaacagaaaa aaaacgccac aaaaacactt cttgttagga   4080

tagatgtggt ggctcctgcc tataatcaca gcactttggg aggccaaggt tagaggatcg   4140

tgtgaagtca agagtttgag accagtctgg acaacacagc aaaaccccca actataccaa   4200

aaacaaaaaa caaccccaga accaaaactt cttgttattg gtaaaagtac tgaattttta   4260

tatgaacatg aaagttaaat gcctgactga tatgaaaatg gtcttgtcaa atgcatgaaa   4320

aaggagcggt tgtcttcagg tgagatgaga gtcatagttt tggagtcttt ctgtaacgtg   4380

ctctcatttt aagagttcca ctcagctgct tcctgtacaa ccctccacag agaaattcca   4440

tatgaaacct ctgtgaaccg aggctgccgt gtgaatctct cccatcagga gaactccact   4500

tctgtgcagt tttccagcct gtgcctgtgg tcttgcattc ctgagacttt gttgtggata   4560

agaagaaaaa ttctgtggcc ttgaaactgt gtctggatgg ttcctccatc tattagtttc   4620

tcattacatt agtggctgcc ccgggatcca agataaacca ttttcccatg cctggtgaga   4680

gactgtagca cagacgcttg atgttttatt gccatgttat tagaaccagc ctcctaattt   4740

gcactggaaa atttgagagg gtaaacatat gggcatatgt cttcatgtgt gccaaactca   4800

cactgtgggc gcgcatgcgg tacacacaca cgttcctttt gttacctctt tgaactctga   4860

atgagatttt gtgagtgtgc acctggggta gaccccttag tattaggtac aaaccccaca   4920

gcagcccgcc tgggttttct ccctcacctg agcatctgag cccagggaga ataagcaggt   4980

aagtgccagc cccttcctgc cgaggcgtgc aaactcgcct gcaaccccta ctccatagcc   5040

acacacgcac tcacagactt aagggtttgc agagcacatt gaggcttccc tcaaagcgca   5100

ttgagcatcc gcatggagag atcaaggatg ggaagggtgc tgggagcagt cgctcatgcc   5160

tgttatccca gcactttggg aggttgaggt gggaagatca cttgagccct ggtcttgaac   5220

tcttgggctg aagttatcct cctgcctcag cctcccaaag tattgggatt ataggcatgg   5280

gccaccatgc ccagctctcc tatctttctt tgtcatcacc ttttctcccc ggcagagctc   5340

cagcctcagg tatccctctt gtggatgctc ctgtttttcc atgggtccat gttgtgatta   5400

tgctgagcca accacactat gtctccctcc tcataaccca aggcacaggc aagtctgtag   5460

gaccatctgg caggagagag ccaaggcctg gacaagcagc cagccgtggg ccccatcttg   5520

gctcactgca acctcccacc tcctgagtac aagtgattct cctgcctcag cttcccgagt   5580

agctgggact ataggctctt gctaccatgc ctggctaatt tttgtatttt tagtagagat   5640

ggggtttcgc catgttggcc agtctcgtct tgaactcctg acctcaggtg atccaccggc   5700

ctcggcctcc caaagtactg ggattacagg cctgagccac aacactcggc cccatcatta   5760

ctttattctt accagctgca ctcactggta ctagcagttc atgatttgcc tgagtcaata   5820

atgatatcac aacatcagat tccactgatc aaaaaaggac ctcgtcagtc tagcactcag   5880

tggcaaaaaa aaaatgttta agttattatt gcagaaaatc tggagccttg ccagtgaata   5940

agatttttaa aggatgtgca aaaaatctag caaaagaggc gtgaatgacc agggatggat   6000

atgagaggag atttagggcg cagtagccta aaatgtgcct ctgcttgcag agatgcaaaa   6060

gagggtaaat gagactttta aagctgattt agacagagga aaaggggaat gggtggtaat   6120

gagacccctg ctggaggtat cacacgtgcc tgggcagccg cggaggaaga ctcatgaagg   6180

gagttgaagg agcaaagcac cagaaccctt ccagccctga gagtctgtga gtctatgagg   6240

cccatgggtg tccaaggatg tgaactgtta tgatagttct agaaatggaa agaacagcta   6300

ctgaataatt atcagtaatt attgcttttc acctaaaatg tgtaatgcag cttccaaaat   6360

tactgacttg gctgagcaca gtggctcgca cgtgtaatcc cagcacttta ggaggctgag   6420

ttgggcaggt cacttgagct taggagtttg agaccagcct gggcatcata gtgggaactt   6480

gtctctacaa aaaatacaaa aattagccaa gcatggtggc acgtacctgt agtcccagct   6540

gcttggaaag ctgaggcggg aggatcttat aaacccaaga ggcagagact acagtgagcc   6600

gtgatcgtgc cactgcattc cagcctaggt gacagagcga gaccctatct gaaaaaa      6657


<210>  1590
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  1590

Met Ala Ser Asn Gly Gly Phe Arg Thr Leu Val Leu Tyr Phe Thr Val 
1               5                   10                  15      


Ala Lys Leu Val Phe Lys Leu Gln Asp Lys Val Leu Phe Lys Ser Ser 
            20                  25                  30          


Leu Leu Phe Pro Leu Leu Leu Glu Leu Arg Ala Val Leu Pro Gly Val 
        35                  40                  45              


Gly Gly Gln Ala Leu Ala Met Ser Ala Ser Val Ser Leu Gly Cys Met 
    50                  55                  60                  


His Thr Lys Pro Thr Gly Ser Lys Val Gly Pro Val Leu Arg Leu Ala 
65                  70                  75                  80  


Gln Glu Leu Trp Ser Leu Trp Pro Lys Leu Ser Phe Lys Phe Ile 
                85                  90                  95  


<210>  1591
<211>  3657
<212>  DNA
<213>  Homosapiens

<400>  1591
gcgtgtgctg gggcgagcgg gagcgggcga ggatgggcac aggatagagg cagagccacc     60

cacgccgccg cggccccacg ctgggcgaca gagcctccag ttccccttca atggtggcgg    120

gtcgccggag ctctgatcgc cgggaaccct tgccgctgct gtcctgcgac cccaagcagg    180

tatagacacg tgtggccgtt tacgctgtag gatcctcatt cccactggct ttgaacattt    240

tggggactta caatgccgcc acccgcggac atcgtcaagg tggccataga atggccgggc    300

gcctacccca aactcatgga aattgatcag aaaaaaccac tgtctgcaat aataaaggaa    360

gtctgtgatg ggtggtctct tgccaaccat gaatattttg cactccagca tgccgatagt    420

tcaaacttct atatcacaga aaagaaccgc aatgagataa aaaatggcac tatccttcga    480

ttaaccacat ctccagctca gaacgcccag cagctccatg aacgaatcca gtcctcgagt    540

atggatgcca agctggaagc cctgaaggac ttggccagcc tctcccggga tgtcacgttt    600

gcccaggagt ttataaacct ggacggtatc tctctcctca cgcagatggt ggagagcggc    660

actgagcgat accagaaatt gcagaagatc atgaagcctt gctttggaga catgctgtcc    720

ttcaccctga cggccttcgt cgagctgatg gaccatggca tagtgtcctg ggatacattt    780

tcggtggcgt tcattaagaa gatagcaagt tttgtgaaca agtcagccat agacatctcg    840

atcctgcagc ggtccttggc cattttggag tcgatggtgc tcaatagcca tgatctctac    900

cagaaagtgg cgcaggagat caccatcggc cagctcattc cacacctgca agggtcagat    960

caagaaatcc aaacctatac tattgcagtg attaatgcgc ttttcctgaa ggctcctgat   1020

gagaggaggc aggagatggc gaatattttg gctcagaagc aactgcgttc catcatttta   1080

acacatgtca tccgagccca gcgggccatc aacaatgaga tggcgcacca gctgtatgtt   1140

ctacaagtgc tcacctttaa cctcctggaa gacaggatga tgaccaaaat ggacccccag   1200

gaccaggctc agagggacat catatttgaa cttcgaagaa ttgcttttga tgctgagtct   1260

gaacctaaca acagcagtgg cagcatggag aaacgcaagt ccatgtacac gcgagattat   1320

aagaagcttg ggttcattaa tcatgtcaac cctgccatgg acttcacgca gactccacct   1380

gggatgttgg ctctggacaa catgctgtac tttgccaagc accaccaaga tgcctacatc   1440

cggattgtgc ttgagaacag tagtcgagaa gacaagcatg aatgtccctt tggccgcagt   1500

agtatagagc tgaccaagat gctatgtgag atcttgaaag tgggcgagtt gcctagtgag   1560

acctgcaacg acttccaccc gatgttcttc acccacgaca gatcctttga ggagtttttc   1620

tgcatctgta tccagctcct gaacaagaca tggaaggaaa tgagggcaac ttctgaagac   1680

ttcaacaagg taatgcaggt ggtgaaggag caggttatga gagcacttac aaccaagcct   1740

agctccctgg accagttcaa gagcaaactg cagaacctga gctacactga gatcctgaaa   1800

atccgccagt ccgagaggat gaaccaggaa gatttccagt cccgcccgat tttggaacta   1860

aaggagaaga ttcagccaga aatcttagag ctgatcaaac agcaacgcct gaaccgcctt   1920

gtggaaggga cctgctttag gaaactcaat gcccggcgga ggcaagacaa gttttggtat   1980

tgtcggcttt cgccaaatca caaagtcctg cattacggag acttagaaga gagtcctcag   2040

ggagaagtgc cccacgattc cttgcaggac aaactgccgg tggcagatat caaagccgtg   2100

gtgacgggaa aggactgccc tcatatgaaa gagaaaggtg cccttaaaca aaacaaggag   2160

gtgcttgaac tcgctttctc catcttgtat gactcaaact gccaactgaa cttcatcgct   2220

cctgacaagc atgagtactg tatctggacg gatggactga atgcgctact cgggaaggac   2280

atgatgagcg acctgacgcg gaatgacctg gacaccctgc tcagcatgga aatcaagctc   2340

cgcctcctgg acctggaaaa catccagatc cctgacgcac ctccgccgat tcccaaggag   2400

cccagcaact atgacttcgt ctatgactgt aactgaagtg gccgggccca gacatgcccc   2460

ttccaaaact ggaacaccta gctaacagga gagaggaatg aaaacacacc cacgccttgg   2520

aaccgtcctt tggtaaaggg aagctgtggg tccacattcc cttcagcatc acctctagcc   2580

ctggcaactt tcagccccta gctggcatct tgctcaccgc cctgattctg ttcctcggct   2640

ccactgcttc aggtcacttc ccatggctgc agtccactgg tgggacaaga gcaaagccca   2700

ctgccagtaa gaaggccaaa gggcccttcc atcctagccc tctgcaggca tgcccttcct   2760

tcccttgggc aggaaagcca gcagccccag actgcccaaa aacttgccca ccagaccaag   2820

ggcagtgccc caaggcccct gtctggagga aatggcctag ctatttgatg agaagaccaa   2880

accccacatc ctcctttccc ctctctctag aatcatctcg caccaccagt tacacttgaa   2940

ttaagatctg cgctcaaatc tcctcccacc tctctccctg cttttgcctt gctctgttcc   3000

tctttggtcc caagagcagc agccgcagcc tcctcgtgat cctccctagc ataaatttcc   3060

caaacagtcc acaggtccca tgcccacttt gcgtctgcac tgtgatcgtg acaaatcttc   3120

cctcctcacc agctagtctg gggtttcctc tccctgcccc aggccagaac tgccttcttc   3180

atttccaccc acgctcccag cctcttagct gaaagcacaa atggtgaaat cagtagtctc   3240

gctccatctc taatagacta aacctaaatg cctctaggac ggactgttgc tatccaagcg   3300

tttggtgtta ccttctcctg ggaggtcctg ctgcaactca agttccacag gatggtcaag   3360

ctgtcagaca tccaagttta catcattgta attattactg gtatttacaa tttgcaagag   3420

ttttgggtta gttttttttt tttttttgct ttgtttttgg acaaaagagt ctaacatttt   3480

ttgccaaaca gatatatatt taatgaaaag aagagataca taaatgtgtg aatttccagt   3540

ttttttttaa ttattttaat cccaaacatc ttcctgaaaa taacattccc ttaaacatgc   3600

tgtggaataa aatggattgt gatgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      3657


<210>  1592
<211>  727
<212>  PRT
<213>  Homosapiens

<400>  1592

Met Pro Pro Pro Ala Asp Ile Val Lys Val Ala Ile Glu Trp Pro Gly 
1               5                   10                  15      


Ala Tyr Pro Lys Leu Met Glu Ile Asp Gln Lys Lys Pro Leu Ser Ala 
            20                  25                  30          


Ile Ile Lys Glu Val Cys Asp Gly Trp Ser Leu Ala Asn His Glu Tyr 
        35                  40                  45              


Phe Ala Leu Gln His Ala Asp Ser Ser Asn Phe Tyr Ile Thr Glu Lys 
    50                  55                  60                  


Asn Arg Asn Glu Ile Lys Asn Gly Thr Ile Leu Arg Leu Thr Thr Ser 
65                  70                  75                  80  


Pro Ala Gln Asn Ala Gln Gln Leu His Glu Arg Ile Gln Ser Ser Ser 
                85                  90                  95      


Met Asp Ala Lys Leu Glu Ala Leu Lys Asp Leu Ala Ser Leu Ser Arg 
            100                 105                 110         


Asp Val Thr Phe Ala Gln Glu Phe Ile Asn Leu Asp Gly Ile Ser Leu 
        115                 120                 125             


Leu Thr Gln Met Val Glu Ser Gly Thr Glu Arg Tyr Gln Lys Leu Gln 
    130                 135                 140                 


Lys Ile Met Lys Pro Cys Phe Gly Asp Met Leu Ser Phe Thr Leu Thr 
145                 150                 155                 160 


Ala Phe Val Glu Leu Met Asp His Gly Ile Val Ser Trp Asp Thr Phe 
                165                 170                 175     


Ser Val Ala Phe Ile Lys Lys Ile Ala Ser Phe Val Asn Lys Ser Ala 
            180                 185                 190         


Ile Asp Ile Ser Ile Leu Gln Arg Ser Leu Ala Ile Leu Glu Ser Met 
        195                 200                 205             


Val Leu Asn Ser His Asp Leu Tyr Gln Lys Val Ala Gln Glu Ile Thr 
    210                 215                 220                 


Ile Gly Gln Leu Ile Pro His Leu Gln Gly Ser Asp Gln Glu Ile Gln 
225                 230                 235                 240 


Thr Tyr Thr Ile Ala Val Ile Asn Ala Leu Phe Leu Lys Ala Pro Asp 
                245                 250                 255     


Glu Arg Arg Gln Glu Met Ala Asn Ile Leu Ala Gln Lys Gln Leu Arg 
            260                 265                 270         


Ser Ile Ile Leu Thr His Val Ile Arg Ala Gln Arg Ala Ile Asn Asn 
        275                 280                 285             


Glu Met Ala His Gln Leu Tyr Val Leu Gln Val Leu Thr Phe Asn Leu 
    290                 295                 300                 


Leu Glu Asp Arg Met Met Thr Lys Met Asp Pro Gln Asp Gln Ala Gln 
305                 310                 315                 320 


Arg Asp Ile Ile Phe Glu Leu Arg Arg Ile Ala Phe Asp Ala Glu Ser 
                325                 330                 335     


Glu Pro Asn Asn Ser Ser Gly Ser Met Glu Lys Arg Lys Ser Met Tyr 
            340                 345                 350         


Thr Arg Asp Tyr Lys Lys Leu Gly Phe Ile Asn His Val Asn Pro Ala 
        355                 360                 365             


Met Asp Phe Thr Gln Thr Pro Pro Gly Met Leu Ala Leu Asp Asn Met 
    370                 375                 380                 


Leu Tyr Phe Ala Lys His His Gln Asp Ala Tyr Ile Arg Ile Val Leu 
385                 390                 395                 400 


Glu Asn Ser Ser Arg Glu Asp Lys His Glu Cys Pro Phe Gly Arg Ser 
                405                 410                 415     


Ser Ile Glu Leu Thr Lys Met Leu Cys Glu Ile Leu Lys Val Gly Glu 
            420                 425                 430         


Leu Pro Ser Glu Thr Cys Asn Asp Phe His Pro Met Phe Phe Thr His 
        435                 440                 445             


Asp Arg Ser Phe Glu Glu Phe Phe Cys Ile Cys Ile Gln Leu Leu Asn 
    450                 455                 460                 


Lys Thr Trp Lys Glu Met Arg Ala Thr Ser Glu Asp Phe Asn Lys Val 
465                 470                 475                 480 


Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro 
                485                 490                 495     


Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr 
            500                 505                 510         


Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe 
        515                 520                 525             


Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile 
    530                 535                 540                 


Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr 
545                 550                 555                 560 


Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr 
                565                 570                 575     


Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu 
            580                 585                 590         


Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu 
        595                 600                 605             


Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His 
    610                 615                 620                 


Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu 
625                 630                 635                 640 


Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala 
                645                 650                 655     


Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu 
            660                 665                 670         


Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr 
        675                 680                 685             


Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile 
    690                 695                 700                 


Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr 
705                 710                 715                 720 


Asp Phe Val Tyr Asp Cys Asn 
                725         


<210>  1593
<211>  2162
<212>  DNA
<213>  Homosapiens

<400>  1593
catttaaagg tgtgcggcgg gtctctgttc acatggctca actggaaacc tgtttcatga     60

acaagcttac tcaggaacca tctggtggta ttccagcaca ttgttcttca gggggacgac    120

tctaagtcgc tttgtggtgg cagcagctta gaatcagtat ttgtggttgg gaaagatgga    180

cttacgggag cttggtaatg caggtggtga aggagcaggt tatgagagca cttacaacca    240

agcctagctc cctggaccag ttcaagagca aactgcagaa cctgagctac actgagatcc    300

tgaaaatccg ccagtccgag aggatgaacc aggaagattt ccagtcccgc ccgattttgg    360

aactaaagga gaagattcag ccagaaatct tagagctgat caaacagcaa cgcctgaacc    420

gccttgtgga agggacctgc tttaggaaac tcaatgcccg gcggaggcaa gacaagtttt    480

ggtattgtcg gctttcgcca aatcacaaag tcctgcatta cggagactta gaagagagtc    540

ctcagggaga agtgccccac gattccttgc aggacaaact gccggtggca gatatcaaag    600

ccgtggtgac gggaaaggac tgccctcata tgaaagagaa aggtgccctt aaacaaaaca    660

aggaggtgct tgaactcgct ttctccatct tgtatgactc aaactgccaa ctgaacttca    720

tcgctcctga caagcatgag tactgtatct ggacggatgg actgaatgcg ctactcggga    780

aggacatgat gagcgacctg acgcggaatg acctggacac cctgctcagc atggaaatca    840

agctccgcct cctggacctg gaaaacatcc agatccctga cgcacctccg ccgattccca    900

aggagcccag caactatgac ttcgtctatg actgtaactg aagtggccgg gcccagacat    960

gccccttcca aaactggaac acctagctaa caggagagag gaatgaaaac acacccacgc   1020

cttggaaccg tcctttggta aagggaagct gtgggtccac attcccttca gcatcacctc   1080

tagccctggc aactttcagc ccctagctgg catcttgctc accgccctga ttctgttcct   1140

cggctccact gcttcaggtc acttcccatg gctgcagtcc actggtggga caagagcaaa   1200

gcccactgcc agtaagaagg ccaaagggcc cttccatcct agccctctgc aggcatgccc   1260

ttccttccct tgggcaggaa agccagcagc cccagactgc ccaaaaactt gcccaccaga   1320

ccaagggcag tgccccaagg cccctgtctg gaggaaatgg cctagctatt tgatgagaag   1380

accaaacccc acatcctcct ttcccctctc tctagaatca tctcgcacca ccagttacac   1440

ttgaattaag atctgcgctc aaatctcctc ccacctctct ccctgctttt gccttgctct   1500

gttcctcttt ggtcccaaga gcagcagccg cagcctcctc gtgatcctcc ctagcataaa   1560

tttcccaaac agtccacagg tcccatgccc actttgcgtc tgcactgtga tcgtgacaaa   1620

tcttccctcc tcaccagcta gtctggggtt tcctctccct gccccaggcc agaactgcct   1680

tcttcatttc cacccacgct cccagcctct tagctgaaag cacaaatggt gaaatcagta   1740

gtctcgctcc atctctaata gactaaacct aaatgcctct aggacggact gttgctatcc   1800

aagcgtttgg tgttaccttc tcctgggagg tcctgctgca actcaagttc cacaggatgg   1860

tcaagctgtc agacatccaa gtttacatca ttgtaattat tactggtatt tacaatttgc   1920

aagagttttg ggttagtttt tttttttttt ttgctttgtt tttggacaaa agagtctaac   1980

attttttgcc aaacagatat atatttaatg aaaagaagag atacataaat gtgtgaattt   2040

ccagtttttt tttaattatt ttaatcccaa acatcttcct gaaaataaca ttcccttaaa   2100

catgctgtgg aataaaatgg attgtgatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2160

aa                                                                  2162


<210>  1594
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  1594

Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro 
1               5                   10                  15      


Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr 
            20                  25                  30          


Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe 
        35                  40                  45              


Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile 
    50                  55                  60                  


Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr 
65                  70                  75                  80  


Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr 
                85                  90                  95      


Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu 
            100                 105                 110         


Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu 
        115                 120                 125             


Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His 
    130                 135                 140                 


Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu 
145                 150                 155                 160 


Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala 
                165                 170                 175     


Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu 
            180                 185                 190         


Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr 
        195                 200                 205             


Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile 
    210                 215                 220                 


Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr 
225                 230                 235                 240 


Asp Phe Val Tyr Asp Cys Asn 
                245         


<210>  1595
<211>  3298
<212>  DNA
<213>  Homosapiens

<400>  1595
atggcttcac tgagaagagt caaagtgctg ttggtgttga acttgatcgc ggtagccggc     60

ttcgtgctct tcctggccaa gtgccggccc atcgcggtgc gcagcggaga cgccttccac    120

gagatccggc cgcgcgccga ggtggccaac ctcagcgcgc acagcgccag ccccatccag    180

gatgcggtcc tgaagcgcct gtcgctgctg gaggacatcg tgtaccggca gctgaatggc    240

ttatccaaat cccttgggct cattgaaggt tatggtgggc ggggtaaagg gggccttccg    300

gctactcttt ccccggctga agaagaaaag gctaagggac cccatgagaa gtatggctac    360

aattcatacc tcagtgaaaa aatttcactg gaccgttcca ttccggatta tcgtcccacc    420

aagtgtaagg agctcaagta ctccaaggac ctgccccaga tatccatcat attcatcttc    480

gtgaacgagg ccctgtcggt gatcctgcgg tccgtgcaca gtgccgtcaa tcacacgccc    540

acacacctgc tgaaggaaat cattctggtg gatgacaaca gcgacgaaga ggagctgaag    600

gtccccctag aggagtatgt ccacaaacgc taccccgggc tggtgaaggt ggtaagaaat    660

cagaagaggg aaggcctgat ccgcgctcgc attgagggct ggaaggtggc taccgggcag    720

gtcactggct tctttgatgc ccacgtggaa ttcaccgctg gctgggctga gccggttcta    780

tcccgcatcc aggaaaaccg gaagcgtgtg atcctcccct ccattgacaa catcaaacag    840

gacaactttg aggtgcagcg gtacgagaac tcggcccacg ggtacagctg ggagctgtgg    900

tgcatgtaca tcagcccccc aaaagactgg tgggacgccg gagacccttc tctccccatc    960

aggaccccag ccatgatagg ctgctcgttc gtggtcaaca ggaagttctt cggtgaaatt   1020

ggtcttctgg atcctggcat ggatgtatac ggaggagaaa atattgaact gggaatcaag   1080

gtatggctct gtgggggcag catggaggtc cttccttgct cacgggtggc ccacattgag   1140

cggaagaaga agccatataa tagcaacatt ggcttctaca ccaagaggaa tgctcttcgc   1200

gttgctgagg tctggatgga cgattacaag tctcatgtgt acatagcgtg gaacctgccg   1260

ctggagaatc cgggaattga catcggtgat gtctccgaaa gaagagcatt aaggaaaagt   1320

ttaaagtgta agaatttcca gtggtacctg gaccatgttt acccagaaat gagaagatac   1380

aataataccg ttgcttacgg ggagcttcgc aacaacaagg caaaagacgt ctgcttggac   1440

caggggccgc tggagaacca cacagcaata ttgtatccgt gccatggctg gggaccacag   1500

cttgcccgct acaccaagga aggcttcctg cacttgggtg ccctggggac caccacactc   1560

ctccctgaca cccgctgcct ggtggacaac tccaagagtc ggctgcccca gctcctggac   1620

tgcgacaagg tcaagagcag cctgtacaag cgctggaact tcatccagaa tggagccatc   1680

atgaacaagg gcacgggacg ctgcctggag gtggagaacc ggggcctggc tggcatcgac   1740

ctcatcctcc gcagctgcac aggtcagagg tggaccatta agaactccat caagtagagg   1800

gagggagctg gggcactgga gcctggcccc caggacatgg ctgctccccc caacatctgg   1860

accagctgcc ctggcggaga gacagcaagg ggccggcagg tgctcgatgg gccccccagg   1920

gcttctccag ggcagcacag ggaccccgga tgaagactct gtcccccctc aggcattcag   1980

ctgcccacaa gtttcctgca ccctggaaaa gccccccacc cttcctctgg gaaactgaca   2040

gctgtcttcc acagcctctg atgtggacct ggtactgagg agcaagactg tccagttctc   2100

ctccacatct cccatcccag aatcaggatc tgggactggc agggtcccct cctgtgtctc   2160

atctcttgca gcagcagctg ctgaactcca gccatcaaca cggtgggagg cagcgggggc   2220

ttcagccatg tcctagctcc ccgccctaaa aggaggcagt gaggaccagg cactatttcc   2280

tccgaggtta cttctaccca gatgacacct gcctgttcac gccccaaggc agctactgcc   2340

cctaaccctt cccaccaggg tagctttggg cactgcagct ctggactttt ctggcccctc   2400

ctgagatgac ctgatggagc tgatgctttc tctcctaatc cctgggcact aggctcttat   2460

cagtgtgctt gggccagctc tcctgcctgt gtctagagga agccagagac agaaataggc   2520

taagcctgca gtaggatctc agccacaagg gccccgcagg atggagctgg gtcaaggacc   2580

agggagccct gactcccaga ggctgccacc ggggagaagc agcggtcctc catccagaac   2640

ctaagggctg aagcaaaggc tgccaggacc cttgaagatg cttttggctc acctcatttc   2700

accccacgct ctgctggctg gcagaggaga aggcagtcgt ttcctctctg aagagtattt   2760

ttttcgattg ccctctggtt agggtgcaca tataaatcag agttaatata tgaacgcgtg   2820

tgcatgcaca agtgtgtgtg tgcctgcgtg ctgtgcgtgg cagggtgtgt gtgtgtgtgt   2880

ctggctgtgc gttccggagt gtgtgacgat gctgacctag ctgtgtggcc ttgggcttgc   2940

tgcttcatta ctcacctgga tggggacgag ggatgagaag ggtgtgggtt tggccccatg   3000

tcactggccg gaaggatgtg tctcagccct gccctgtggg gtgcccccga tgggaggctg   3060

tcccatctcc cagtccccat ctctttttcc ccacactgtc cctggccaag ccctgcccag   3120

agctgaaccc tgtagctgcc cccttgccct gtgtgggatt cgcagtgtct catttggtga   3180

cgtcttactg gtgatcatct cctcacccca tctcccacct tgtggaataa atacatgtta   3240

gcacttccca aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaaaaaaa aaaaaaaa     3298


<210>  1596
<211>  598
<212>  PRT
<213>  Homosapiens

<400>  1596

Met Ala Ser Leu Arg Arg Val Lys Val Leu Leu Val Leu Asn Leu Ile 
1               5                   10                  15      


Ala Val Ala Gly Phe Val Leu Phe Leu Ala Lys Cys Arg Pro Ile Ala 
            20                  25                  30          


Val Arg Ser Gly Asp Ala Phe His Glu Ile Arg Pro Arg Ala Glu Val 
        35                  40                  45              


Ala Asn Leu Ser Ala His Ser Ala Ser Pro Ile Gln Asp Ala Val Leu 
    50                  55                  60                  


Lys Arg Leu Ser Leu Leu Glu Asp Ile Val Tyr Arg Gln Leu Asn Gly 
65                  70                  75                  80  


Leu Ser Lys Ser Leu Gly Leu Ile Glu Gly Tyr Gly Gly Arg Gly Lys 
                85                  90                  95      


Gly Gly Leu Pro Ala Thr Leu Ser Pro Ala Glu Glu Glu Lys Ala Lys 
            100                 105                 110         


Gly Pro His Glu Lys Tyr Gly Tyr Asn Ser Tyr Leu Ser Glu Lys Ile 
        115                 120                 125             


Ser Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Thr Lys Cys Lys Glu 
    130                 135                 140                 


Leu Lys Tyr Ser Lys Asp Leu Pro Gln Ile Ser Ile Ile Phe Ile Phe 
145                 150                 155                 160 


Val Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Ala Val 
                165                 170                 175     


Asn His Thr Pro Thr His Leu Leu Lys Glu Ile Ile Leu Val Asp Asp 
            180                 185                 190         


Asn Ser Asp Glu Glu Glu Leu Lys Val Pro Leu Glu Glu Tyr Val His 
        195                 200                 205             


Lys Arg Tyr Pro Gly Leu Val Lys Val Val Arg Asn Gln Lys Arg Glu 
    210                 215                 220                 


Gly Leu Ile Arg Ala Arg Ile Glu Gly Trp Lys Val Ala Thr Gly Gln 
225                 230                 235                 240 


Val Thr Gly Phe Phe Asp Ala His Val Glu Phe Thr Ala Gly Trp Ala 
                245                 250                 255     


Glu Pro Val Leu Ser Arg Ile Gln Glu Asn Arg Lys Arg Val Ile Leu 
            260                 265                 270         


Pro Ser Ile Asp Asn Ile Lys Gln Asp Asn Phe Glu Val Gln Arg Tyr 
        275                 280                 285             


Glu Asn Ser Ala His Gly Tyr Ser Trp Glu Leu Trp Cys Met Tyr Ile 
    290                 295                 300                 


Ser Pro Pro Lys Asp Trp Trp Asp Ala Gly Asp Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Arg Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asn Arg Lys Phe 
                325                 330                 335     


Phe Gly Glu Ile Gly Leu Leu Asp Pro Gly Met Asp Val Tyr Gly Gly 
            340                 345                 350         


Glu Asn Ile Glu Leu Gly Ile Lys Val Trp Leu Cys Gly Gly Ser Met 
        355                 360                 365             


Glu Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Lys Lys Lys 
    370                 375                 380                 


Pro Tyr Asn Ser Asn Ile Gly Phe Tyr Thr Lys Arg Asn Ala Leu Arg 
385                 390                 395                 400 


Val Ala Glu Val Trp Met Asp Asp Tyr Lys Ser His Val Tyr Ile Ala 
                405                 410                 415     


Trp Asn Leu Pro Leu Glu Asn Pro Gly Ile Asp Ile Gly Asp Val Ser 
            420                 425                 430         


Glu Arg Arg Ala Leu Arg Lys Ser Leu Lys Cys Lys Asn Phe Gln Trp 
        435                 440                 445             


Tyr Leu Asp His Val Tyr Pro Glu Met Arg Arg Tyr Asn Asn Thr Val 
    450                 455                 460                 


Ala Tyr Gly Glu Leu Arg Asn Asn Lys Ala Lys Asp Val Cys Leu Asp 
465                 470                 475                 480 


Gln Gly Pro Leu Glu Asn His Thr Ala Ile Leu Tyr Pro Cys His Gly 
                485                 490                 495     


Trp Gly Pro Gln Leu Ala Arg Tyr Thr Lys Glu Gly Phe Leu His Leu 
            500                 505                 510         


Gly Ala Leu Gly Thr Thr Thr Leu Leu Pro Asp Thr Arg Cys Leu Val 
        515                 520                 525             


Asp Asn Ser Lys Ser Arg Leu Pro Gln Leu Leu Asp Cys Asp Lys Val 
    530                 535                 540                 


Lys Ser Ser Leu Tyr Lys Arg Trp Asn Phe Ile Gln Asn Gly Ala Ile 
545                 550                 555                 560 


Met Asn Lys Gly Thr Gly Arg Cys Leu Glu Val Glu Asn Arg Gly Leu 
                565                 570                 575     


Ala Gly Ile Asp Leu Ile Leu Arg Ser Cys Thr Gly Gln Arg Trp Thr 
            580                 585                 590         


Ile Lys Asn Ser Ile Lys 
        595             


<210>  1597
<211>  2079
<212>  DNA
<213>  Homosapiens

<400>  1597
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag gtaaataaac ctgaatgcca tgtgggccat tctattcccc ctatgtgtag    840

aactgtaact cacattaaag gttaacagca acgaatcaat cataacaaat atgttgttcg    900

tgcaaatgca actacaaata attatttaaa catttttata caatgttttt aaaactgttg    960

gattatcacc agattaatgc aaaataacag agcgagttat cagtttgaat ttcaacactg   1020

cctgagacat ccctctgggg aaagtgaaag agagggttta cttacctact gtcttgagct   1080

cacatacctc aaaatctact actgtgtggc acctgaaagg agttgaatga agcttagcct   1140

ttcattagca atgttaattc tattcaacca gcacctgctt ccacagaaat tctgtccaaa   1200

ctatcatgaa gtggtgtgac aagggtatat ggacccagaa gataatacaa tataagaagg   1260

gatcactgga agcttgaccc catgcacatt ttggtgaaaa tgtgcctaga atcaaatgtg   1320

acacgtaggc tggaactgag taccattcag aataggatct gaagagatca aagcaatgga   1380

gaccaccaaa ctgtcttgaa ggcatgtcta tggaccttaa gtccatgtct atgttttcag   1440

ctcttctcac agcataaaag ggcattgtcc ttacttttgc agtggaaaac tgaatggctg   1500

acaagatgga agagtaacca tttcagcatt gtatgtggtt tcatttttct tagttatctg   1560

gctactgaat agccggattt ttcagttctg tcagaaactc taaatttcca aaaatctaag   1620

tgaaacatgg atgaaactct gttagaaaat tgttaggatt ttggagtatt tggggagggg   1680

gactactgga atgctgtcca agttttatac taagatatct tacctgtttg ttattaacca   1740

aatattttta aaaatatttc ctccataaat attcatttaa tattaggttg atatttatca   1800

cataaaaagt aaaggctact gttagctaat tgtcacagag aaggatttgt tttctgttgt   1860

tagtgaattt gaaatccttg actttatgtg ctacagccag ttccatctct gtttgtaaat   1920

tcttactttc cattccatat catattctgt tccctataac ctcttcattg ttttcttttc   1980

ttttaaaaat aataaacttt tctatgatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          2079


<210>  1598
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  1598

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Gly Lys 
    210 


<210>  1599
<211>  2820
<212>  DNA
<213>  Homosapiens

<400>  1599
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat    840

acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc    900

ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc    960

cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt   1020

aaaacatgcg ctgacaatac tatgaatgac actgatgttc ctttggaaac aactgaatgc   1080

atccaaggtc aaggagaagg ctacaggggc actgtcaata ccatttggaa tggaattcca   1140

tgtcagcgtt gggattctca gtatcctcac gagcatgaca tgactcctga aaatttcaag   1200

tgcaaggacc tacgagaaaa ttactgccga aatccagatg ggtctgaatc accctggtgt   1260

tttaccactg atccaaacat ccgagttggc tactgctccc aaattccaaa ctgtgatatg   1320

tcacatggac aagattgtta tcgtgggaat ggcaaaaatt atatgggcaa cttatcccaa   1380

acaagatctg gactaacatg ttcaatgtgg gacaagaaca tggaagactt acatcgtcat   1440

atcttctggg aaccagatgc aagtaagctg aatgagaatt actgccgaaa tccagatgat   1500

gatgctcatg gaccctggtg ctacacggga aatccactca ttccttggga ttattgccct   1560

atttctcgtt gtgaaggtga taccacacct acaatagtca atttagacca tcccgtaata   1620

tcttgtgcca aaacgaaaca attgcgagtt gtaaatggga ttccaacacg aacaaacata   1680

ggatggatgg ttagtttgag atacagaaat aaacatatct gcggaggatc attgataaag   1740

gagagttggg ttcttactgc acgacagtgt ttcccttctc gagacttgaa agattatgaa   1800

gcttggcttg gaattcatga tgtccacgga agaggagatg agaaatgcaa acaggttctc   1860

aatgtttccc agctggtata tggccctgaa ggatcagatc tggttttaat gaagcttgcc   1920

aggcctgctg tcctggatga ttttgttagt acgattgatt tacctaatta tggatgcaca   1980

attcctgaaa agaccagttg cagtgtttat ggctggggct acactggatt gatcaactat   2040

gatggcctat tacgagtggc acatctctat ataatgggaa atgagaaatg cagccagcat   2100

catcgaggga aggtgactct gaatgagtct gaaatatgtg ctggggctga aaagattgga   2160

tcaggaccat gtgaggggga ttatggtggc ccacttgttt gtgagcaaca taaaatgaga   2220

atggttcttg gtgtcattgt tcctggtcgt ggatgtgcca ttccaaatcg tcctggtatt   2280

tttgtccgag tagcatatta tgcaaaatgg atacacaaaa ttattttaac atataaggta   2340

ccacagtcat agctgaagta agtgtgtctg aagcacccac caatacaact gtcttttaca   2400

tgaagatttc agagaatgtg gaatttaaaa tgtcacttac aacaatccta agacaactac   2460

tggagagtca tgtttgttga aattctcatt aatgtttatg ggtgttttct gttgttttgt   2520

ttgtcagtgt tattttgtca atgttgaagt gaattaaggt acatgcaagt gtaataacat   2580

atctcctgaa gatacttgaa tggattaaaa aaacacacag gtatatttgc tggatgataa   2640

agatttcatg ggaaaaaaaa tcaattaatc tgtctaagct gctttctgat gttggtttct   2700

taataatgag taaaccacaa attaaatgtt attttaacct caccaaaaca atttatacct   2760

tgtgtcccta aattgtagcc ctatattaaa ttatattaca tttcaaaaaa aaaaaaaaaa   2820


<210>  1600
<211>  728
<212>  PRT
<213>  Homosapiens

<400>  1600

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  1601
<211>  1307
<212>  DNA
<213>  Homosapiens

<400>  1601
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat    840

acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc    900

ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc    960

cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt   1020

aaaacatgcg agacataaca tgggctctca actgatggtg aacttcttct ggtgagtgac   1080

agaggctgca gtgaagaata atgagtctaa tagaagttta tcacagatgt ctctaatctt   1140

tatagctgat ccctacctct ctcgctgtct ttgtacccag cctgcattct gtttcgatct   1200

gtcttttagc agtccataca atcatttttc tacatgctgg cccttaccta gcttttctga   1260

atttacaata aaaactattt tttaacgtga aaaaaaaaaa aaaaaaa                 1307


<210>  1602
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  1602

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Glu Thr 
    290 


<210>  1603
<211>  2805
<212>  DNA
<213>  Homosapiens

<400>  1603
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagcta tcggggtaaa    660

gacctacagg aaaactactg tcgaaatcct cgaggggaag aagggggacc ctggtgtttc    720

acaagcaatc cagaggtacg ctacgaagtc tgtgacattc ctcagtgttc agaagttgaa    780

tgcatgacct gcaatgggga gagttatcga ggtctcatgg atcatacaga atcaggcaag    840

atttgtcagc gctgggatca tcagacacca caccggcaca aattcttgcc tgaaagatat    900

cccgacaagg gctttgatga taattattgc cgcaatcccg atggccagcc gaggccatgg    960

tgctatactc ttgaccctca cacccgctgg gagtactgtg caattaaaac atgcgctgac   1020

aatactatga atgacactga tgttcctttg gaaacaactg aatgcatcca aggtcaagga   1080

gaaggctaca ggggcactgt caataccatt tggaatggaa ttccatgtca gcgttgggat   1140

tctcagtatc ctcacgagca tgacatgact cctgaaaatt tcaagtgcaa ggacctacga   1200

gaaaattact gccgaaatcc agatgggtct gaatcaccct ggtgttttac cactgatcca   1260

aacatccgag ttggctactg ctcccaaatt ccaaactgtg atatgtcaca tggacaagat   1320

tgttatcgtg ggaatggcaa aaattatatg ggcaacttat cccaaacaag atctggacta   1380

acatgttcaa tgtgggacaa gaacatggaa gacttacatc gtcatatctt ctgggaacca   1440

gatgcaagta agctgaatga gaattactgc cgaaatccag atgatgatgc tcatggaccc   1500

tggtgctaca cgggaaatcc actcattcct tgggattatt gccctatttc tcgttgtgaa   1560

ggtgatacca cacctacaat agtcaattta gaccatcccg taatatcttg tgccaaaacg   1620

aaacaattgc gagttgtaaa tgggattcca acacgaacaa acataggatg gatggttagt   1680

ttgagataca gaaataaaca tatctgcgga ggatcattga taaaggagag ttgggttctt   1740

actgcacgac agtgtttccc ttctcgagac ttgaaagatt atgaagcttg gcttggaatt   1800

catgatgtcc acggaagagg agatgagaaa tgcaaacagg ttctcaatgt ttcccagctg   1860

gtatatggcc ctgaaggatc agatctggtt ttaatgaagc ttgccaggcc tgctgtcctg   1920

gatgattttg ttagtacgat tgatttacct aattatggat gcacaattcc tgaaaagacc   1980

agttgcagtg tttatggctg gggctacact ggattgatca actatgatgg cctattacga   2040

gtggcacatc tctatataat gggaaatgag aaatgcagcc agcatcatcg agggaaggtg   2100

actctgaatg agtctgaaat atgtgctggg gctgaaaaga ttggatcagg accatgtgag   2160

ggggattatg gtggcccact tgtttgtgag caacataaaa tgagaatggt tcttggtgtc   2220

attgttcctg gtcgtggatg tgccattcca aatcgtcctg gtatttttgt ccgagtagca   2280

tattatgcaa aatggataca caaaattatt ttaacatata aggtaccaca gtcatagctg   2340

aagtaagtgt gtctgaagca cccaccaata caactgtctt ttacatgaag atttcagaga   2400

atgtggaatt taaaatgtca cttacaacaa tcctaagaca actactggag agtcatgttt   2460

gttgaaattc tcattaatgt ttatgggtgt tttctgttgt tttgtttgtc agtgttattt   2520

tgtcaatgtt gaagtgaatt aaggtacatg caagtgtaat aacatatctc ctgaagatac   2580

ttgaatggat taaaaaaaca cacaggtata tttgctggat gataaagatt tcatgggaaa   2640

aaaaatcaat taatctgtct aagctgcttt ctgatgttgg tttcttaata atgagtaaac   2700

cacaaattaa atgttatttt aacctcacca aaacaattta taccttgtgt ccctaaattg   2760

tagccctata ttaaattata ttacatttca aaaaaaaaaa aaaaa                   2805


<210>  1604
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  1604

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp Asn Thr Met 
        275                 280                 285             


Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu Cys Ile Gln Gly Gln 
    290                 295                 300                 


Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Pro 
305                 310                 315                 320 


Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro 
                325                 330                 335     


Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro 
            340                 345                 350         


Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg 
        355                 360                 365             


Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln 
    370                 375                 380                 


Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln 
385                 390                 395                 400 


Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp 
                405                 410                 415     


Leu His Arg His Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys 
    450                 455                 460                 


Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu Asp His Pro Val Ile 
465                 470                 475                 480 


Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val Asn Gly Ile Pro Thr 
                485                 490                 495     


Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg Tyr Arg Asn Lys His 
            500                 505                 510         


Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp Val Leu Thr Ala Arg 
        515                 520                 525             


Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr Glu Ala Trp Leu Gly 
    530                 535                 540                 


Ile His Asp Val His Gly Arg Gly Asp Glu Lys Cys Lys Gln Val Leu 
545                 550                 555                 560 


Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly Ser Asp Leu Val Leu 
                565                 570                 575     


Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp Phe Val Ser Thr Ile 
            580                 585                 590         


Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu Lys Thr Ser Cys Ser 
        595                 600                 605             


Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn Tyr Asp Gly Leu Leu 
    610                 615                 620                 


Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu Lys Cys Ser Gln His 
625                 630                 635                 640 


His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu Ile Cys Ala Gly Ala 
                645                 650                 655     


Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp Tyr Gly Gly Pro Leu 
            660                 665                 670         


Val Cys Glu Gln His Lys Met Arg Met Val Leu Gly Val Ile Val Pro 
        675                 680                 685             


Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly Ile Phe Val Arg Val 
    690                 695                 700                 


Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile Leu Thr Tyr Lys Val 
705                 710                 715                 720 


Pro Gln Ser 
            


<210>  1605
<211>  1292
<212>  DNA
<213>  Homosapiens

<400>  1605
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagcta tcggggtaaa    660

gacctacagg aaaactactg tcgaaatcct cgaggggaag aagggggacc ctggtgtttc    720

acaagcaatc cagaggtacg ctacgaagtc tgtgacattc ctcagtgttc agaagttgaa    780

tgcatgacct gcaatgggga gagttatcga ggtctcatgg atcatacaga atcaggcaag    840

atttgtcagc gctgggatca tcagacacca caccggcaca aattcttgcc tgaaagatat    900

cccgacaagg gctttgatga taattattgc cgcaatcccg atggccagcc gaggccatgg    960

tgctatactc ttgaccctca cacccgctgg gagtactgtg caattaaaac atgcgagaca   1020

taacatgggc tctcaactga tggtgaactt cttctggtga gtgacagagg ctgcagtgaa   1080

gaataatgag tctaatagaa gtttatcaca gatgtctcta atctttatag ctgatcccta   1140

cctctctcgc tgtctttgta cccagcctgc attctgtttc gatctgtctt ttagcagtcc   1200

atacaatcat ttttctacat gctggccctt acctagcttt tctgaattta caataaaaac   1260

tattttttaa cgtgaaaaaa aaaaaaaaaa aa                                 1292


<210>  1606
<211>  285
<212>  PRT
<213>  Homosapiens

<400>  1606

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Glu Thr 
        275                 280                 285 


<210>  1607
<211>  1852
<212>  DNA
<213>  Homosapiens

<400>  1607
ctgggctgag gcggaggcag gggagttgca gcgcgcgagg ctccgtgagt gtgtctcctg     60

cgcgctgaga ggcgggggga ggcggaggac caggaggagg aggaggagga ggaggagggg    120

gagaatgccc ggagccgccg ccgctgccgc cgccgccgcc gccgcgatgc tcccggctca    180

ggaggctgcc aagctgtacc acaccaacta tgtgcggaac tcgcgggcca tcggcgtgct    240

gtgggccatc ttcaccatct gctttgccat cgtcaacgtg gtgtgcttca tccagcccta    300

ctggataggc gacggcgtgg acaccccgca agccggctat ttcgggctct tccactactg    360

catcggcaac ggcttctccc gggagctgac ctgcaggggc agcttcacgg acttctccac    420

gctgccctcg ggcgccttca aagccgcctc cttctttatc ggcctctcca tgatgctcat    480

cattgcctgc atcatttgct ttaccctctt cttcttctgc aacacggcca ctgtgtacaa    540

gatatgtgcc tggatgcagc tcacctccgc tgcctgcctt gtgcttggct gtatgatttt    600

ccctgatggc tgggactcag atgaagtaaa acggatgtgt ggagaaaaga cagacaagta    660

cactcttggg gcttgctcag tccgctgggc atacatcctg gctattattg gaattttgga    720

tgccctgatc ctctcatttc tagcatttgt gcttggtaat cgacaagaca gcttgatggc    780

agaggaactg aaggcagaaa acaaagttct gctaagccaa tattctctag aatgagcaca    840

aaacaaatcg aataacagct aaacaaatcg aataacagct aaacgaatcg aataacagct    900

tttgtacatc aacatcaaga aggaatacgc ctgagagaga tcagagtata tagatgaata    960

tgaacaagaa tggaacattc acttgtcaac gcactttcta aatctagatc agcagagatg   1020

ggagtgattt tctggaaaga gatgtgatca tggattaaac accagctcat tggaaactca   1080

ttggatgaga tcagaaaacg ttcatgaaaa atcatattca ggaaataagg aagaggaata   1140

taaatgctct agagttaaca tgtaaaatat atacgtactg aggtttgtaa actgtccttt   1200

ttaaatcaaa ctgaaaacaa aaagctttaa cctttcaaca gaatttttaa aaaggcagtt   1260

agttctaaat tattcctatc tcaatagcca agaggctgat caagcgtcat ttattgagga   1320

agcatcttag aaaatgcctc tgaatgtttt cataggagcc gtgacctttg gttcttcatc   1380

tctaccattc atttacttca ctgtgtaatt agttacaacc actcagttat taagagacgt   1440

aacgcttcaa actttttacc aagtctgtgt tctgtttaat ctgtccatac aagttattac   1500

tgagaaagtg tttatgccat atactattac tccatcaagc tgtatattac aggaagtaca   1560

tctttacatc ataggttccc aagcaacata gatttcccta tctttcagga aacagcatca   1620

aggaactctg aaaaatatag aaaaagttca ttttcacctt ggaagctcac gtgtaatatt   1680

ataggctact atcaaataaa cacttttttt ctaattctcc ctagtatatg cataggaatt   1740

taatatactt tataaataag tatctaaaat gtctcctact tttttcctat ttctttgcca   1800

tacatgttat cagaaatcca tgtcttctat ttcccttact gatgggcact ca           1852


<210>  1608
<211>  236
<212>  PRT
<213>  Homosapiens

<400>  1608

Met Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Met Leu 
1               5                   10                  15      


Pro Ala Gln Glu Ala Ala Lys Leu Tyr His Thr Asn Tyr Val Arg Asn 
            20                  25                  30          


Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala 
        35                  40                  45              


Ile Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly 
    50                  55                  60                  


Val Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile 
65                  70                  75                  80  


Gly Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp 
                85                  90                  95      


Phe Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile 
            100                 105                 110         


Gly Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu 
        115                 120                 125             


Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met 
    130                 135                 140                 


Gln Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro 
145                 150                 155                 160 


Asp Gly Trp Asp Ser Asp Glu Val Lys Arg Met Cys Gly Glu Lys Thr 
                165                 170                 175     


Asp Lys Tyr Thr Leu Gly Ala Cys Ser Val Arg Trp Ala Tyr Ile Leu 
            180                 185                 190         


Ala Ile Ile Gly Ile Leu Asp Ala Leu Ile Leu Ser Phe Leu Ala Phe 
        195                 200                 205             


Val Leu Gly Asn Arg Gln Asp Ser Leu Met Ala Glu Glu Leu Lys Ala 
    210                 215                 220                 


Glu Asn Lys Val Leu Leu Ser Gln Tyr Ser Leu Glu 
225                 230                 235     


<210>  1609
<211>  663
<212>  DNA
<213>  Homosapiens

<400>  1609
atgaagctgc ccggcgccat tttgcttgtg ggctgccgcc cgccgttgcc tctccgcgga     60

ggctcgaaga tagcaaactg gaggcgccca gtctggcctc cagcgctggg tgaacccggt    120

tggggtgtca ctcgacgccc actaggggct gaggaggctc cagtgcgcag gctccgggca    180

ccggataaaa gcggagctgg cgagtctagt gctgtctcga tggaggagca agaaacggaa    240

gaggtcgggg ggagaagcag ccggaaaaat gcagccaccg tcaacgccgc ctccctgcca    300

ccgtgcttcg ggagagggag aagtgacgat ggtgatcgtt gctgccgcgg ccgatatgga    360

acccaagcag tggcgaaggg aatcgcaagg ctcttccctg accattttct actgtccctg    420

cgcgaggtgg acgcaaaggt gttaaatgag gttgaatata ttgaccagaa aagaaaatat    480

tatagtcctt tgttgaagaa gagttttctc atactggaaa gaaaaaaaat aaaagaaaga    540

aacttcaaaa acttcatgct gctttctgaa gtactccagc caaagaaaat aattcaggta    600

tcaagttgga ctagctcaga tgactacaaa atggtgagta cattcagata tgggagatta    660

tga                                                                  663


<210>  1610
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  1610

Met Lys Leu Pro Gly Ala Ile Leu Leu Val Gly Cys Arg Pro Pro Leu 
1               5                   10                  15      


Pro Leu Arg Gly Gly Ser Lys Ile Ala Asn Trp Arg Arg Pro Val Trp 
            20                  25                  30          


Pro Pro Ala Leu Gly Glu Pro Gly Trp Gly Val Thr Arg Arg Pro Leu 
        35                  40                  45              


Gly Ala Glu Glu Ala Pro Val Arg Arg Leu Arg Ala Pro Asp Lys Ser 
    50                  55                  60                  


Gly Ala Gly Glu Ser Ser Ala Val Ser Met Glu Glu Gln Glu Thr Glu 
65                  70                  75                  80  


Glu Val Gly Gly Arg Ser Ser Arg Lys Asn Ala Ala Thr Val Asn Ala 
                85                  90                  95      


Ala Ser Leu Pro Pro Cys Phe Gly Arg Gly Arg Ser Asp Asp Gly Asp 
            100                 105                 110         


Arg Cys Cys Arg Gly Arg Tyr Gly Thr Gln Ala Val Ala Lys Gly Ile 
        115                 120                 125             


Ala Arg Leu Phe Pro Asp His Phe Leu Leu Ser Leu Arg Glu Val Asp 
    130                 135                 140                 


Ala Lys Val Leu Asn Glu Val Glu Tyr Ile Asp Gln Lys Arg Lys Tyr 
145                 150                 155                 160 


Tyr Ser Pro Leu Leu Lys Lys Ser Phe Leu Ile Leu Glu Arg Lys Lys 
                165                 170                 175     


Ile Lys Glu Arg Asn Phe Lys Asn Phe Met Leu Leu Ser Glu Val Leu 
            180                 185                 190         


Gln Pro Lys Lys Ile Ile Gln Val Ser Ser Trp Thr Ser Ser Asp Asp 
        195                 200                 205             


Tyr Lys Met Val Ser Thr Phe Arg Tyr Gly Arg Leu 
    210                 215                 220 


<210>  1611
<211>  6543
<212>  DNA
<213>  Homosapiens

<400>  1611
aagaggctgc gcgctgctgt ttggggaggg ggtgtgtgga gccgggtcct gtgtccgcag     60

tggctgctgt cggggggtcg cctgttcgcg gaggtgcgga gagactcctt gggggtcgag    120

cactgtggct ggcatgcccc agtgttttgg ataccaatgc ataggactcc atagtaatcg    180

aatttaccag aggcgaacgt catgagcata gtgatcccat tgggggttga tacagcagag    240

acgtcatact tggaaatggc tgcaggttca gaaccagaat ccgtagaagc tagccctgtg    300

gtagttgaga aatccaacag ttatccccac cagttatata ccagcagctc acatcattca    360

cacagttaca ttggtttgcc ctatgcggac cataattatg gtgctcgtcc tcctccgaca    420

cctccggctt cccctcctcc atcagtcctt attagcaaaa atgaagtagg catatttacc    480

actcctaatt ttgatgaaac ttccagtgct actacaatca gcacatctga ggatggaagt    540

tatggtactg atgtaaccag gtgcatatgt ggttttacac atgatgatgg atacatgatc    600

tgttgtgaca aatgcagcgt ttggcaacat attgactgca tggggattga taggcagcat    660

attcctgata catatctatg tgaacgttgt cagcctagga atttggataa agagagggca    720

gtgctactac aacgccggaa aagggaaaat atgtcagatg gtgataccag tgcaactgag    780

agtggtgatg aggttcctgt ggaattatat actgcatttc agcatactcc aacatcaatt    840

actttaactg cttcaagagt ttccaaagtt aatgataaaa gaaggaaaaa aagcggggag    900

aaagaacaac acatttcaaa atgtaaaaag gcatttcgtg aaggatctag gaagtcatca    960

agagttaagg gttcagctcc agagattgat ccttcatctg atggttcaaa ttttggatgg   1020

gagacaaaga tcaaagcatg gatggatcga tatgaagaag caaataacaa ccagtatagt   1080

gagggtgttc agagggaggc acaaagaata gctctgagat taggcaatgg aaatgacaaa   1140

aaagagatga ataaatccga tttgaatacc aacaatttgc tcttcaaacc tcctgtagag   1200

agccatatac aaaagaataa gaaaattctt aaatctgcaa aagatttgcc tcctgatgca   1260

cttatcattg aatacagagg gaagtttatg ctgagagaac agtttgaagc aaatgggtat   1320

ttctttaaaa gaccataccc ttttgtgtta ttctactcta aatttcatgg gctagaaatg   1380

tgtgttgatg caaggacttt tgggaatgag gctcgattca tcaggcggtc ttgtacaccc   1440

aatgcagagg tgaggcatga aattcaagat ggaaccatac atctttatat ttattctata   1500

cacagtattc caaagggaac tgaaattact attgcctttg attttgacta tggaaattgt   1560

aagtacaagg tggactgtgc atgcctcaaa gaaaacccag agtgccctgt tctaaaacgt   1620

agttctgaat ccatggaaaa tatcaatagt ggttatgaga ccagacggaa aaaaggaaaa   1680

aaagacgaag atatttcaaa agaaaaagat acacaaaatc agaatattac tttggattgt   1740

gaaggagcga ccaacaaaat gaagagccca gaaactaaac aaagaaagct ttctccactg   1800

agactatcag tatcaaataa tcaggaacca gattttattg atgatataga agaaaaaact   1860

cctattagta atgaagtaga aatggaatca gaggagcaga ttgcagaaag gaaaaggaag   1920

atgacaagag aagaaagaaa aatggaagca attttgcaag cttttgccag acttgaaaag   1980

agagagaaaa gaagagaaca agctttggaa aggatcagca cagccaaaac tgaagttaaa   2040

actgaatgta aagatacaca gattgtcagt gatgctgaag ttattcagga acaagcaaaa   2100

gaagaaaatg ctagcaagcc aacccctgcc aaagtaaata gaactaaaca gagaaaaagt   2160

ttttctcgga gtaggactca cattggacag cagcgtcgga gacacagaac tgtcagcatg   2220

tgttcagata tccagccatc ttctcctgat atagaagtta cttcacaaca aaatgatatt   2280

gaaaatactg tacttacaat agaaccagaa actgaaactg cactagcaga aataattact   2340

gaaactgaag ttccagcact taataaatgt cctaccaagt accccaaaac aaagaagcac   2400

ttggttaatg aatggttaag tgagaagaat gagaagacag gaaaaccttc agatggcctt   2460

tcagaaaggc ctctacgcat aactacagat cctgaagtgt tagctacaca actcaattct   2520

ttaccaggtc tcacttacag cccccatgta tactccactc ctaagcatta tattagattt   2580

acttcaccat tcctttcaga aaaaaggaga agaaaagaac ctactgaaaa catttctggt   2640

tcatgcaaga agcgatggtt gaaacaagct ctggaagaag aaaattcagc aattttacat   2700

agatttaatt caccctgtca agaaagatcc agaagtcctg cagtcaatgg tgaaaataaa   2760

agtccactac tattaaatga cagctgttcc cttccagatt taactacacc actaaaaaaa   2820

cgaagatttt atcagttgct agattcggtt tactcagaaa cctccacacc tactccttcc   2880

ccgtatgcta caccaactca caccgatatt actcctatgg acccatcttt tgccacgcct   2940

ccacggataa aatcggatga tgaaacttgt agaaatggtt ataaacccat atattcacca   3000

gttaccccag taactcctgg tacaccagga aataccatgc actttgagaa tatttcttcc   3060

ccagaaagtt ctccagaaat aaagagacgc acttatagtc aagagggata tgacagatct   3120

tcaaccatgt taacattggg gccttttaga aattctaatt taactgaact gggtctgcaa   3180

gaaataaaga ctattggtta tacgagccct aggagtagga ctgaagtcaa caggcagtgt   3240

cctggagaaa aggaacctgc gtcagacctt cagctaggac tcgatgcagt tgagccaact   3300

gccctacata aaaccctgga aacgcctgca catgacaggg ctgagcccaa cagccaactg   3360

gactcgactc actctggacg gggcacaatg tattcttcct gggtaaagag ccctgacagt   3420

acaggagtta acttctcagt gaactccaac ttgagggacc tgacaccccc gcatcagttg   3480

gaggttggag gaggctcccg aataagtgag tcaaagtgcc tgatgcagga tgacaccaga   3540

ggcatgttta tggaaacaac tgtgttttgt acttccgaag atgggcttgt atctggtttc   3600

ggacggactg ttaatgacaa tttgatcgac gggaattgca caccccagaa tccaccacaa   3660

aagaaaaagg tttctctatt agaataccgt aagagacaac gtaaagctag gaaaagtggc   3720

tctaagacag agaactttcc actcattagt gtatcacccc atgcaagtgg aagcttgagc   3780

aacaatggtg atggctgtgc cagcagtaat gacaatgggg agcaggtgga ccacactgct   3840

agcctacctt taccaacacc agctacagtt tataatgcca cttctgaaga aactagcaat   3900

aactgccctg ttaaggatgc tactgctagt gagaagaatg aaccagaagt tcaatggact   3960

gcctcaactt cagtggaaca agtcagagaa aggagttatc agagagcttt acttctcagt   4020

gatcaccgaa aagataaaga tagtggggga gaatcaccat gtgtctcatg ttcaccgagt   4080

catgttcagt cttcaccttc atctcattca aatcacatac cccagttgca agctaagggc   4140

ccagtccctt ctttcagtga acttatggaa gaccctgatc ctgaaaatcc agaacccaca   4200

actacgaatg aatgtccatc cccagatact tctcaaaata cttgtaaaag tcctccaaaa   4260

atgagcaagc ctggttcacc tggatctgta attcctgctc aagcacacgg gaaaatattc   4320

acaaaaccag atccccaatg ggactccaca gttagtgcat ccgaagctga aaatggtgtt   4380

cacctaaaaa cagagctcca acaaaaacag ctatcaaata acaaccaagc actttcaaag   4440

aatcatcctc ctcagacaca cgttcgtaat tcatctgagc aactttcaca aaagctgcct   4500

tctgtgccaa caaagttgca ctgtcctcca tcacctcacc tagaaaatcc tccaaagtca   4560

tccacgcctc acacacctgt acagcatggt tatctttcac caaagcctcc ttcacagcag   4620

ttaggatctc cctacaggcc tcatcattca cagtcacctc aagttggaac acctcagcga   4680

gagcctcaaa gaaactttta tccagcagca cagaaccttc cagccaatac tcagcaggca   4740

acttctggaa cattatttac acagacaccc tcaggacaat cttcagcaac atacagtcag   4800

tttaaccaac aaagtctgaa cagcacggca ccaccccctc cacctcctcc acctccttct   4860

tcgtcttact atcaaaacca gcagccctct gcaaactttc agaattataa tcagctcaaa   4920

ggtagtcttt ctcaacaaac tgtgtttaca tcaggaccaa atcaagcact tcctggcacc   4980

acaagccagc aaacagttcc aggacaccac gtgactccag ggcatttttt gccctctcag   5040

aaccctacca ttcaccatca aactgctgct gccgtagtcc cccctcctcc tccaccacca   5100

cctgctccag gaccgcacct tgtacaacag ccgaattccc atcagcaaca ctctgtagca   5160

catgtagtag ggcctgttca tgcggtcacc cctgggtcgc atattcattc tcaaactgct   5220

ggacaccact tacccccacc cccaccccct cctggtcctg cccctcatca ccatccacca   5280

ccccatccat ccacaggact ccaaggtcta caagcacaac accagcatgt tgtaaattca   5340

gcacccccac caccccctcc gccgccacct tccagtgttt tggcttctgg gcatcatacc   5400

acatcagctc aagccttaca ccacccacct catcaaggac ctccactttt tccttcgagt   5460

gctcatccaa ctgtaccacc gtatccctca caagctacac atcataccac tttgggaccg   5520

ggaccccagc accagccttc tggaacaggg ccacattgtc cattacctgt cacaggtcct   5580

catctccagc cccaaggacc aaacagtatt ccaacaccta ctgcttcagg gttctgtcct   5640

catcctggct ctgtggccct gccacatggg gttcaaggac ctcagcaggc atctccagtg   5700

cctggacaga ttccaattca cagagcacag gtgccaccaa catttcaaaa caattaccat   5760

gggtcagggt ggcattaaaa tggactccaa aaacattttt ttaaatgttc tgtaagataa   5820

actgtatatt tcatatgtac ctgttaaggt actttttaaa gcttgtacat gaacctttgt   5880

ataaaaaaca ccagtgctct ttcgttgtat ttttctcatt tttgcttttt aaaattcctt   5940

taaaaaatgt gctgttaagc cagtattagg tatctttatt ttgtaagtga acattccagc   6000

tgtttttttc tggcagatct gatgctgatt tgatgctgta tgatcttttt ttttttttta   6060

gttaaattca tttagtgaat gttctattat tttatacata cacattaagt actcagctaa   6120

gtaatggcac tatgaggatt ttttttttct ttcctgtcag cagcagttct gtgaatgcat   6180

cttaggtata aaaatgcaat acagattttt atattttggt gtggacatgg ctcattttgt   6240

tttaccagtt atttgcaagc aaaatgtaat ttaatgtata gatgatttct aatgtctcct   6300

gacaaactgt aaatactgca tttcttttgc gtatataatt gcttacagct tttctcattt   6360

gatatatagc attgtacata tgacaagtct tttgcaaaac tgtgtgatct ttgtgaaagt   6420

agtacagtat atgaccttta atttcttttt tattttaaat atactgtcac actgaagcac   6480

tggttgggca ttttaattca tgttaataaa tcccaattat gtcagattta aaaaaaaaaa   6540

aaa                                                                 6543


<210>  1612
<211>  1858
<212>  PRT
<213>  Homosapiens

<400>  1612

Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr 
1               5                   10                  15      


Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser 
        35                  40                  45              


Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His 
    50                  55                  60                  


Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro 
65                  70                  75                  80  


Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn 
                85                  90                  95      


Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly 
            100                 105                 110         


Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp 
        115                 120                 125             


Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile 
    130                 135                 140                 


Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys 
145                 150                 155                 160 


Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu 
                165                 170                 175     


Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr 
            180                 185                 190         


Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His 
        195                 200                 205             


Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn 
    210                 215                 220                 


Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys 
225                 230                 235                 240 


Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys 
                245                 250                 255     


Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly 
            260                 265                 270         


Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn 
        275                 280                 285             


Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala 
    290                 295                 300                 


Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp 
305                 310                 315                 320 


Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile 
                325                 330                 335     


Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp 
            340                 345                 350         


Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe 
        355                 360                 365             


Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe 
    370                 375                 380                 


Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe 
385                 390                 395                 400 


Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu 
                405                 410                 415     


Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser 
            420                 425                 430         


Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe 
        435                 440                 445             


Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu 
    450                 455                 460                 


Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn 
465                 470                 475                 480 


Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Glu 
                485                 490                 495     


Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp 
            500                 505                 510         


Cys Glu Gly Ala Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg 
        515                 520                 525             


Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp 
    530                 535                 540                 


Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu 
545                 550                 555                 560 


Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg 
                565                 570                 575     


Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu 
            580                 585                 590         


Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala 
        595                 600                 605             


Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp 
    610                 615                 620                 


Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro 
625                 630                 635                 640 


Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg 
                645                 650                 655     


Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser 
            660                 665                 670         


Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser 
        675                 680                 685             


Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr 
    690                 695                 700                 


Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu 
705                 710                 715                 720 


Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn 
                725                 730                 735     


Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly 
            740                 745                 750         


Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala 
        755                 760                 765             


Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr 
    770                 775                 780                 


Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu 
785                 790                 795                 800 


Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys 
                805                 810                 815     


Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu 
            820                 825                 830         


His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val 
        835                 840                 845             


Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu 
    850                 855                 860                 


Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu 
865                 870                 875                 880 


Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala 
                885                 890                 895     


Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr 
            900                 905                 910         


Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys 
        915                 920                 925             


Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn 
    930                 935                 940                 


Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met 
                965                 970                 975     


Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu 
            980                 985                 990         


Gln Glu Ile Lys Thr Ile Gly Tyr  Thr Ser Pro Arg Ser  Arg Thr Glu 
        995                 1000                 1005             


Val Asn  Arg Gln Cys Pro Gly  Glu Lys Glu Pro Ala  Ser Asp Leu 
    1010                 1015                 1020             


Gln Leu  Gly Leu Asp Ala Val  Glu Pro Thr Ala Leu  His Lys Thr 
    1025                 1030                 1035             


Leu Glu  Thr Pro Ala His Asp  Arg Ala Glu Pro Asn  Ser Gln Leu 
    1040                 1045                 1050             


Asp Ser  Thr His Ser Gly Arg  Gly Thr Met Tyr Ser  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Pro Asp Ser Thr Gly  Val Asn Phe Ser Val  Asn Ser Asn 
    1070                 1075                 1080             


Leu Arg  Asp Leu Thr Pro Pro  His Gln Leu Glu Val  Gly Gly Gly 
    1085                 1090                 1095             


Ser Arg  Ile Ser Glu Ser Lys  Cys Leu Met Gln Asp  Asp Thr Arg 
    1100                 1105                 1110             


Gly Met  Phe Met Glu Thr Thr  Val Phe Cys Thr Ser  Glu Asp Gly 
    1115                 1120                 1125             


Leu Val  Ser Gly Phe Gly Arg  Thr Val Asn Asp Asn  Leu Ile Asp 
    1130                 1135                 1140             


Gly Asn  Cys Thr Pro Gln Asn  Pro Pro Gln Lys Lys  Lys Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Tyr Arg Lys Arg  Gln Arg Lys Ala Arg  Lys Ser Gly 
    1160                 1165                 1170             


Ser Lys  Thr Glu Asn Phe Pro  Leu Ile Ser Val Ser  Pro His Ala 
    1175                 1180                 1185             


Ser Gly  Ser Leu Ser Asn Asn  Gly Asp Gly Cys Ala  Ser Ser Asn 
    1190                 1195                 1200             


Asp Asn  Gly Glu Gln Val Asp  His Thr Ala Ser Leu  Pro Leu Pro 
    1205                 1210                 1215             


Thr Pro  Ala Thr Val Tyr Asn  Ala Thr Ser Glu Glu  Thr Ser Asn 
    1220                 1225                 1230             


Asn Cys  Pro Val Lys Asp Ala  Thr Ala Ser Glu Lys  Asn Glu Pro 
    1235                 1240                 1245             


Glu Val  Gln Trp Thr Ala Ser  Thr Ser Val Glu Gln  Val Arg Glu 
    1250                 1255                 1260             


Arg Ser  Tyr Gln Arg Ala Leu  Leu Leu Ser Asp His  Arg Lys Asp 
    1265                 1270                 1275             


Lys Asp  Ser Gly Gly Glu Ser  Pro Cys Val Ser Cys  Ser Pro Ser 
    1280                 1285                 1290             


His Val  Gln Ser Ser Pro Ser  Ser His Ser Asn His  Ile Pro Gln 
    1295                 1300                 1305             


Leu Gln  Ala Lys Gly Pro Val  Pro Ser Phe Ser Glu  Leu Met Glu 
    1310                 1315                 1320             


Asp Pro  Asp Pro Glu Asn Pro  Glu Pro Thr Thr Thr  Asn Glu Cys 
    1325                 1330                 1335             


Pro Ser  Pro Asp Thr Ser Gln  Asn Thr Cys Lys Ser  Pro Pro Lys 
    1340                 1345                 1350             


Met Ser  Lys Pro Gly Ser Pro  Gly Ser Val Ile Pro  Ala Gln Ala 
    1355                 1360                 1365             


His Gly  Lys Ile Phe Thr Lys  Pro Asp Pro Gln Trp  Asp Ser Thr 
    1370                 1375                 1380             


Val Ser  Ala Ser Glu Ala Glu  Asn Gly Val His Leu  Lys Thr Glu 
    1385                 1390                 1395             


Leu Gln  Gln Lys Gln Leu Ser  Asn Asn Asn Gln Ala  Leu Ser Lys 
    1400                 1405                 1410             


Asn His  Pro Pro Gln Thr His  Val Arg Asn Ser Ser  Glu Gln Leu 
    1415                 1420                 1425             


Ser Gln  Lys Leu Pro Ser Val  Pro Thr Lys Leu His  Cys Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Leu Glu Asn Pro  Pro Lys Ser Ser Thr  Pro His Thr 
    1445                 1450                 1455             


Pro Val  Gln His Gly Tyr Leu  Ser Pro Lys Pro Pro  Ser Gln Gln 
    1460                 1465                 1470             


Leu Gly  Ser Pro Tyr Arg Pro  His His Ser Gln Ser  Pro Gln Val 
    1475                 1480                 1485             


Gly Thr  Pro Gln Arg Glu Pro  Gln Arg Asn Phe Tyr  Pro Ala Ala 
    1490                 1495                 1500             


Gln Asn  Leu Pro Ala Asn Thr  Gln Gln Ala Thr Ser  Gly Thr Leu 
    1505                 1510                 1515             


Phe Thr  Gln Thr Pro Ser Gly  Gln Ser Ser Ala Thr  Tyr Ser Gln 
    1520                 1525                 1530             


Phe Asn  Gln Gln Ser Leu Asn  Ser Thr Ala Pro Pro  Pro Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro Pro Ser Ser Ser  Tyr Tyr Gln Asn Gln  Gln Pro Ser 
    1550                 1555                 1560             


Ala Asn  Phe Gln Asn Tyr Asn  Gln Leu Lys Gly Ser  Leu Ser Gln 
    1565                 1570                 1575             


Gln Thr  Val Phe Thr Ser Gly  Pro Asn Gln Ala Leu  Pro Gly Thr 
    1580                 1585                 1590             


Thr Ser  Gln Gln Thr Val Pro  Gly His His Val Thr  Pro Gly His 
    1595                 1600                 1605             


Phe Leu  Pro Ser Gln Asn Pro  Thr Ile His His Gln  Thr Ala Ala 
    1610                 1615                 1620             


Ala Val  Val Pro Pro Pro Pro  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1625                 1630                 1635             


His Leu  Val Gln Gln Pro Asn  Ser His Gln Gln His  Ser Val Ala 
    1640                 1645                 1650             


His Val  Val Gly Pro Val His  Ala Val Thr Pro Gly  Ser His Ile 
    1655                 1660                 1665             


His Ser  Gln Thr Ala Gly His  His Leu Pro Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Pro Gly  Pro Ala Pro His His  His Pro Pro Pro His  Pro Ser Thr 
    1685                 1690                 1695             


Gly Leu  Gln Gly Leu Gln Ala  Gln His Gln His Val  Val Asn Ser 
    1700                 1705                 1710             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Ser Ser  Val Leu Ala 
    1715                 1720                 1725             


Ser Gly  His His Thr Thr Ser  Ala Gln Ala Leu His  His Pro Pro 
    1730                 1735                 1740             


His Gln  Gly Pro Pro Leu Phe  Pro Ser Ser Ala His  Pro Thr Val 
    1745                 1750                 1755             


Pro Pro  Tyr Pro Ser Gln Ala  Thr His His Thr Thr  Leu Gly Pro 
    1760                 1765                 1770             


Gly Pro  Gln His Gln Pro Ser  Gly Thr Gly Pro His  Cys Pro Leu 
    1775                 1780                 1785             


Pro Val  Thr Gly Pro His Leu  Gln Pro Gln Gly Pro  Asn Ser Ile 
    1790                 1795                 1800             


Pro Thr  Pro Thr Ala Ser Gly  Phe Cys Pro His Pro  Gly Ser Val 
    1805                 1810                 1815             


Ala Leu  Pro His Gly Val Gln  Gly Pro Gln Gln Ala  Ser Pro Val 
    1820                 1825                 1830             


Pro Gly  Gln Ile Pro Ile His  Arg Ala Gln Val Pro  Pro Thr Phe 
    1835                 1840                 1845             


Gln Asn  Asn Tyr His Gly Ser  Gly Trp His 
    1850                 1855             


<210>  1613
<211>  7139
<212>  DNA
<213>  Homosapiens

<400>  1613
cgccgccatt ttcccagagc gagaggcagt gacactgagc gggcgcaggg ggccgagtcg     60

gagaccgtgc cggagttcgg gagcggcaac agagtgggca tagacactcc gagcagcctc    120

gccgtcgtct ctgcgttcct gttgactgcc tggctgcccc ctcccctact cctcggttcc    180

tggtgaagag gctgcgcgct gctgtttggg gagggggtgt gtggagccgg gtcctgtgtc    240

cgcagtggct gctgtcgggg ggtcgcctgt tcgcggaggt gcggagagac tccttggggg    300

tcgagcacat aacggggttc gggtgtctcg tgtgtgaaca tcacaggtct attctggata    360

agcaggtttt gtgaagacat ttattctttc ttggacctca gatttaccag acatctcatg    420

ggtttgtgga tgcacttaga tgtttgcaat gagcactgtg gctggcatgc cccagtgttt    480

tggataccaa tgcataggac tccatagtaa tcgaatttac cagaggcgaa cgtcatgagc    540

atagtgatcc cattgggggt tgatacagca gagacgtcat acttggaaat ggctgcaggt    600

tcagaaccag aatccgtaga agctagccct gtggtagttg agaaatccaa cagttatccc    660

caccagttat ataccagcag ctcacatcat tcacacagtt acattggttt gccctatgcg    720

gaccataatt atggtgctcg tcctcctccg acacctccgg cttcccctcc tccatcagtc    780

cttattagca aaaatgaagt aggcatattt accactccta attttgatga aacttccagt    840

gctactacaa tcagcacatc tgaggatgga agttatggta ctgatgtaac caggtgcata    900

tgtggtttta cacatgatga tggatacatg atctgttgtg acaaatgcag cgtttggcaa    960

catattgact gcatggggat tgataggcag catattcctg atacatatct atgtgaacgt   1020

tgtcagccta ggaatttgga taaagagagg gcagtgctac tacaacgccg gaaaagggaa   1080

aatatgtcag atggtgatac cagtgcaact gagagtggtg atgaggttcc tgtggaatta   1140

tatactgcat ttcagcatac tccaacatca attactttaa ctgcttcaag agtttccaaa   1200

gttaatgata aaagaaggaa aaaaagcggg gagaaagaac aacacatttc aaaatgtaaa   1260

aaggcatttc gtgaaggatc taggaagtca tcaagagtta agggttcagc tccagagatt   1320

gatccttcat ctgatggttc aaattttgga tgggagacaa agatcaaagc atggatggat   1380

cgatatgaag aagcaaataa caaccagtac agtgagggtg ttcagaggga ggcacaaaga   1440

atagctctga gattaggcaa tggaaatgac aaaaaagaga tgaataaatc cgatttgaat   1500

accaacaatt tgctcttcaa acctcctgta gagagccata tacaaaagaa taagaaaatt   1560

cttaaatctg caaaagattt gcctcctgat gcacttatca ttgaatacag agggaagttt   1620

atgctgagag aacagtttga agcaaatggg tatttcttta aaagaccata cccttttgtg   1680

ttattctact ctaaatttca tgggctagaa atgtgtgttg atgcaaggac ttttgggaat   1740

gaggctcgat tcatcaggcg gtcttgtaca cccaatgcag aggtgaggca tgaaattcaa   1800

gatggaacca tacatcttta tatttattct atacacagta ttccaaaggg aactgaaatt   1860

actattgcct ttgattttga ctatggaaat tgtaagtaca aggtggactg tgcatgcctc   1920

aaagaaaacc cagagtgccc tgttctaaaa cgtagttctg aatccatgga aaatatcaat   1980

agtggttatg agaccagacg gaaaaaagga aaaaaagaca aagatatttc aaaagaaaaa   2040

gatacacaaa atcagaatat tactttggat tgtgaaggaa cgaccaacaa aatgaagagc   2100

ccagaaacta aacaaagaaa gctttctcca ctgagactat cagtatcaaa taatcaggaa   2160

ccagatttta ttgatgatat agaagaaaaa actcctatta gtaatgaagt agaaatggaa   2220

tcagaggagc agattgcaga aaggaaaagg aagatgacaa gagaagaaag aaaaatggaa   2280

gcaattttgc aagcttttgc cagacttgaa aagagagaga aaagaagaga acaagctttg   2340

gaaaggatca gcacagccaa aactgaagtt aaaactgaat gtaaagatac acagattgtc   2400

agtgatgctg aagttattca ggaacaagca aaagaagaaa atgctagcaa gccaacccct   2460

gccaaagtaa atagaactaa acagagaaaa agtttttctc ggagtaggac tcacattgga   2520

cagcagcgtc ggagacacag aactgtcagc atgtgttcag atatccagcc atcttctcct   2580

gatatagaag ttacttcaca acaaaatgat attgaaaata ctgtacttac aatagaacca   2640

gaaactgaaa ctgcactagc agaaataatt actgaaactg aagttccagc acttaataaa   2700

tgtcctacca agtaccccaa aacaaagaag cacttggtta atgaatggtt aagtgagaag   2760

aatgagaaga caggaaaacc ttcagatggc ctttcagaaa ggcctctacg cataactaca   2820

gatcctgaag tgttagctac acaactcaat tctttaccag gtctcactta cagcccccat   2880

gtatactcca ctcctaagca ttatattaga tttacttcac cattcctttc agaaaaaagg   2940

agaagaaaag aacctactga aaacatttct ggttcatgca agaagcgatg gttgaaacaa   3000

gctctggaag aagaaaattc agcaatttta catagattta attcaccctg tcaagaaaga   3060

tccagaagtc ctgcagtcaa tggtgaaaat aaaagtccac tactattaaa tgacagctgt   3120

tcccttccag atttaactac accactaaaa aaacgaagat tttatcagtt gctagattcg   3180

gtttactcag aaacctccac acctactcct tccccgtatg ctacaccaac tcacaccgat   3240

attactccta tggacccatc ttttgccacg cctccacgga taaaatcaga tgatgaaact   3300

tgtagaaatg gttataaacc catatattca ccagttaccc cagtaactcc tggtacacca   3360

ggaaatacca tgcactttga gaatatttct tccccagaaa gttctccaga aataaagaga   3420

cgcacttata gtcaagaggg atatgacaga tcttcaacca tgttaacatt ggggcctttt   3480

agaaattcta atttaactga actgggtctg caagaaataa agactattgg ttatacgagc   3540

cctaggagta ggactgaagt caacaggcag tgtcctggag aaaaggaacc tgtgtcagac   3600

cttcagctag gactcgatgc agttgagcca actgccctac ataaaaccct ggaaacgcct   3660

gcacatgaca gggctgagcc caacagccaa ctggactcga ctcactctgg acggggcaca   3720

atgtattctt cctgggtaaa gagccctgac agaacaggag ttaacttctc agtgaactcc   3780

aacttgaggg acctgacacc ctcgcatcag ttggaggttg gaggaggctt ccgaataagt   3840

gagtcaaagt gcctgatgca ggatgatact agaggcatgt ttatggaaac aactgtgttt   3900

tgtacttccg aagatgggct tgtatctggt ttcggacgga ctgttaatga caatttgatc   3960

gacgggaatt gcacacccca gaatccacca caaaagaaaa aggtttctct attagaatac   4020

cgtaagagac aacgtgaagc taggaaaagt ggctctaaga cagagaactt tccactcatt   4080

agtgtatcac cccatgcaag tggaagcttg agcaacaatg gtgatggctg tgccagcagt   4140

aatgacaatg gggagcaggt ggaccacact gctagcctac ctttaccaac accagctaca   4200

gtttataatg ccacttctga agaaactagc aataactgcc ctgttaagga tgctactgct   4260

agtgagaaga atgaaccaga agttcaatgg actgcctcaa cttcagtgga acaagtcaga   4320

gaaaggagtt atcagagagc tttacttctc agtgatcacc gaaaagataa agatagtggg   4380

ggagaatcac catgtgtctc atgttcaccg agtcatgttc agtcttcacc ttcatctcat   4440

tcaaatcaca taccccagtt gcaagctaag ggcccagtcc cttctttcag tgaacttatg   4500

gaagaccctg atcctgaaaa tccagaaccc acaactacga atgaatgtcc atccccagat   4560

acttctcaaa atacttgtaa aagtcctcca aaaatgagca agcctggttc acctggatct   4620

gtaattcctg ctcaagcaca cgggaaaata ttcacaaaac cagatcccca atgggactcc   4680

acagttagtg catccgaagc tgaaaatggt gttcacctaa aaacagagct ccaacaaaaa   4740

cagctatcaa ataacaacca agcactttca aagaatcatc ctcctcagac acacgttcgt   4800

aattcatctg agcaactttc acaaaagctg ccttctgtgc caacaaagtt gcactgtcct   4860

ccatcacctc acctagaaaa tcctccaaag tcatccacgc ctcacacacc tgtacagcat   4920

ggttatcttt caccaaagcc tccttcacag cagttaggat ctccctacag gcctcatcat   4980

tcacagtcac ctcaagttgg aacacctcag cgagagcctc aaagaaactt ttatccagca   5040

gcacagaacc ttccagccaa tactcagcag gcaacttctg gaacattatt tacacagaca   5100

ccctcaggac aatcttcagc aacatacagt cagtttaacc aacaaagtct gaacagcacg   5160

gcaccacccc ctccacctcc tccacctcct tcttcgtctt actatcaaaa ccagcagccc   5220

tctgcaaact ttcagaatta taatcagctc aaaggtagtc tttctcaaca aactgtgttt   5280

acatcaggac caaatcaagc acttcctggc accacaagcc agcaaacagt tccaggacac   5340

cacgtgactc cagggcattt tttgccctct cagaacccta ccattcacca tcaaactgct   5400

gctgccgtag tcccccctcc tcctccacca ccacctgctc caggaccgca ccttgtacaa   5460

cagccgaatt cccatcagca acactctgta gcacatgtag tagggcctgt tcatgcggtc   5520

acccctgggt cgcatattca ttctcaaact gctggacacc acttaccccc acccccaccc   5580

cctcctggtc ctgcccctca tcaccatcca ccaccccatc catccacagg actccaaggt   5640

ctacaagcac aacaccagca tgttgtaaat tcagcacccc caccaccccc tccgccgcca   5700

ccttccagtg ttttggcttc tgggcatcat accacatcag ctcaagcctt acaccaccca   5760

cctcatcaag gacctccact ttttccttcg agtgctcatc caactgtacc accgtatccc   5820

tcacaagcta cacatcatac cactttggga ccgggacccc agcaccagcc ttctggaaca   5880

gggccacatt gtccattacc tgtcacaggt cctcatctcc agccccaagg accaaacagt   5940

attccaacac ctactgcttc agggttctgt cctcatcctg gctctgtggc cctgccacat   6000

ggggttcaag gacctcagca ggcatctcca gtgcctggac agattccaat tcacagagca   6060

caggtgccac caacatttca aaacaattac catgggtcag ggtggcatta aaatggactc   6120

caaaaacatt tttttaaatg ttctgtaaga taaactgtat atttcatatg tacctgttaa   6180

ggtacttttt aaagcttgta catgaacctt tgtataaaaa acaccagtgc tctttcgttg   6240

tatttttctc atttttgctt tttaaaattc ctttaaaaaa tgtgctgtta agccagtatt   6300

aggtatcttt attttgtaag tgaacattcc agctgttttt ttctggcaga tctgatgctg   6360

atttgatgct gtatgatctt tttttttttt ttagttaaat tcatttagtg aatgttctat   6420

tattttatac atacacatta agtactcagc taagtaatgg cactatgagg attttttttt   6480

tctttcctgt cagcagcagt tctgtgaatg catcttaggt ataaaaatgc aatacagatt   6540

tttatatttt ggtgtggaca tggctcattt tgttttacca gttatttgca agcaaaatgt   6600

aatttaatgt atagatgatt tctaatgtct cctgacaaac tgtaaatact gcatttcttt   6660

tgcgtatata attgcttaca gcttttctca tttgatatat agcattgtac atatgacaag   6720

tcttttgcaa aactgtgtga tctttgtgaa agtagtacag tatatgacct ttaatttctt   6780

ttttatttta aatatactgt cacactgaag cactggttgg gcattttaat tcatgttaat   6840

aaatcacaat tatgtcagtt ttaccagatt gtcctgtaca acttctaaga tcgggatctg   6900

tgtgtttcta cagaagttct agttttcaaa tatagattgt aaggagcctt caattttctt   6960

tagcgactac tacctcagca acaggaggca gcaaggggct gttcctgtgg tggtttctgt   7020

ttgcattttt gcaggagcca taggaaacta ctgaaatgat tgtgctgggt aaattaagga   7080

tctggcatca tacaaaatga agccagacca ctaatgcatt acagtagttc ttgaataca    7139


<210>  1614
<211>  1858
<212>  PRT
<213>  Homosapiens

<400>  1614

Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr 
1               5                   10                  15      


Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser 
        35                  40                  45              


Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His 
    50                  55                  60                  


Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro 
65                  70                  75                  80  


Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn 
                85                  90                  95      


Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly 
            100                 105                 110         


Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp 
        115                 120                 125             


Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile 
    130                 135                 140                 


Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys 
145                 150                 155                 160 


Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu 
                165                 170                 175     


Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr 
            180                 185                 190         


Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His 
        195                 200                 205             


Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn 
    210                 215                 220                 


Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys 
225                 230                 235                 240 


Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys 
                245                 250                 255     


Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly 
            260                 265                 270         


Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn 
        275                 280                 285             


Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala 
    290                 295                 300                 


Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp 
305                 310                 315                 320 


Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile 
                325                 330                 335     


Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp 
            340                 345                 350         


Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe 
        355                 360                 365             


Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe 
    370                 375                 380                 


Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe 
385                 390                 395                 400 


Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu 
                405                 410                 415     


Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser 
            420                 425                 430         


Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe 
        435                 440                 445             


Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu 
    450                 455                 460                 


Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn 
465                 470                 475                 480 


Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys 
                485                 490                 495     


Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp 
            500                 505                 510         


Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg 
        515                 520                 525             


Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp 
    530                 535                 540                 


Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu 
545                 550                 555                 560 


Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg 
                565                 570                 575     


Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu 
            580                 585                 590         


Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala 
        595                 600                 605             


Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp 
    610                 615                 620                 


Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro 
625                 630                 635                 640 


Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg 
                645                 650                 655     


Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser 
            660                 665                 670         


Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser 
        675                 680                 685             


Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr 
    690                 695                 700                 


Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu 
705                 710                 715                 720 


Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn 
                725                 730                 735     


Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly 
            740                 745                 750         


Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala 
        755                 760                 765             


Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr 
    770                 775                 780                 


Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu 
785                 790                 795                 800 


Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys 
                805                 810                 815     


Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu 
            820                 825                 830         


His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val 
        835                 840                 845             


Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu 
    850                 855                 860                 


Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu 
865                 870                 875                 880 


Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala 
                885                 890                 895     


Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr 
            900                 905                 910         


Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys 
        915                 920                 925             


Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn 
    930                 935                 940                 


Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met 
                965                 970                 975     


Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu 
            980                 985                 990         


Gln Glu Ile Lys Thr Ile Gly Tyr  Thr Ser Pro Arg Ser  Arg Thr Glu 
        995                 1000                 1005             


Val Asn  Arg Gln Cys Pro Gly  Glu Lys Glu Pro Val  Ser Asp Leu 
    1010                 1015                 1020             


Gln Leu  Gly Leu Asp Ala Val  Glu Pro Thr Ala Leu  His Lys Thr 
    1025                 1030                 1035             


Leu Glu  Thr Pro Ala His Asp  Arg Ala Glu Pro Asn  Ser Gln Leu 
    1040                 1045                 1050             


Asp Ser  Thr His Ser Gly Arg  Gly Thr Met Tyr Ser  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Pro Asp Arg Thr Gly  Val Asn Phe Ser Val  Asn Ser Asn 
    1070                 1075                 1080             


Leu Arg  Asp Leu Thr Pro Ser  His Gln Leu Glu Val  Gly Gly Gly 
    1085                 1090                 1095             


Phe Arg  Ile Ser Glu Ser Lys  Cys Leu Met Gln Asp  Asp Thr Arg 
    1100                 1105                 1110             


Gly Met  Phe Met Glu Thr Thr  Val Phe Cys Thr Ser  Glu Asp Gly 
    1115                 1120                 1125             


Leu Val  Ser Gly Phe Gly Arg  Thr Val Asn Asp Asn  Leu Ile Asp 
    1130                 1135                 1140             


Gly Asn  Cys Thr Pro Gln Asn  Pro Pro Gln Lys Lys  Lys Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Tyr Arg Lys Arg  Gln Arg Glu Ala Arg  Lys Ser Gly 
    1160                 1165                 1170             


Ser Lys  Thr Glu Asn Phe Pro  Leu Ile Ser Val Ser  Pro His Ala 
    1175                 1180                 1185             


Ser Gly  Ser Leu Ser Asn Asn  Gly Asp Gly Cys Ala  Ser Ser Asn 
    1190                 1195                 1200             


Asp Asn  Gly Glu Gln Val Asp  His Thr Ala Ser Leu  Pro Leu Pro 
    1205                 1210                 1215             


Thr Pro  Ala Thr Val Tyr Asn  Ala Thr Ser Glu Glu  Thr Ser Asn 
    1220                 1225                 1230             


Asn Cys  Pro Val Lys Asp Ala  Thr Ala Ser Glu Lys  Asn Glu Pro 
    1235                 1240                 1245             


Glu Val  Gln Trp Thr Ala Ser  Thr Ser Val Glu Gln  Val Arg Glu 
    1250                 1255                 1260             


Arg Ser  Tyr Gln Arg Ala Leu  Leu Leu Ser Asp His  Arg Lys Asp 
    1265                 1270                 1275             


Lys Asp  Ser Gly Gly Glu Ser  Pro Cys Val Ser Cys  Ser Pro Ser 
    1280                 1285                 1290             


His Val  Gln Ser Ser Pro Ser  Ser His Ser Asn His  Ile Pro Gln 
    1295                 1300                 1305             


Leu Gln  Ala Lys Gly Pro Val  Pro Ser Phe Ser Glu  Leu Met Glu 
    1310                 1315                 1320             


Asp Pro  Asp Pro Glu Asn Pro  Glu Pro Thr Thr Thr  Asn Glu Cys 
    1325                 1330                 1335             


Pro Ser  Pro Asp Thr Ser Gln  Asn Thr Cys Lys Ser  Pro Pro Lys 
    1340                 1345                 1350             


Met Ser  Lys Pro Gly Ser Pro  Gly Ser Val Ile Pro  Ala Gln Ala 
    1355                 1360                 1365             


His Gly  Lys Ile Phe Thr Lys  Pro Asp Pro Gln Trp  Asp Ser Thr 
    1370                 1375                 1380             


Val Ser  Ala Ser Glu Ala Glu  Asn Gly Val His Leu  Lys Thr Glu 
    1385                 1390                 1395             


Leu Gln  Gln Lys Gln Leu Ser  Asn Asn Asn Gln Ala  Leu Ser Lys 
    1400                 1405                 1410             


Asn His  Pro Pro Gln Thr His  Val Arg Asn Ser Ser  Glu Gln Leu 
    1415                 1420                 1425             


Ser Gln  Lys Leu Pro Ser Val  Pro Thr Lys Leu His  Cys Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Leu Glu Asn Pro  Pro Lys Ser Ser Thr  Pro His Thr 
    1445                 1450                 1455             


Pro Val  Gln His Gly Tyr Leu  Ser Pro Lys Pro Pro  Ser Gln Gln 
    1460                 1465                 1470             


Leu Gly  Ser Pro Tyr Arg Pro  His His Ser Gln Ser  Pro Gln Val 
    1475                 1480                 1485             


Gly Thr  Pro Gln Arg Glu Pro  Gln Arg Asn Phe Tyr  Pro Ala Ala 
    1490                 1495                 1500             


Gln Asn  Leu Pro Ala Asn Thr  Gln Gln Ala Thr Ser  Gly Thr Leu 
    1505                 1510                 1515             


Phe Thr  Gln Thr Pro Ser Gly  Gln Ser Ser Ala Thr  Tyr Ser Gln 
    1520                 1525                 1530             


Phe Asn  Gln Gln Ser Leu Asn  Ser Thr Ala Pro Pro  Pro Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro Pro Ser Ser Ser  Tyr Tyr Gln Asn Gln  Gln Pro Ser 
    1550                 1555                 1560             


Ala Asn  Phe Gln Asn Tyr Asn  Gln Leu Lys Gly Ser  Leu Ser Gln 
    1565                 1570                 1575             


Gln Thr  Val Phe Thr Ser Gly  Pro Asn Gln Ala Leu  Pro Gly Thr 
    1580                 1585                 1590             


Thr Ser  Gln Gln Thr Val Pro  Gly His His Val Thr  Pro Gly His 
    1595                 1600                 1605             


Phe Leu  Pro Ser Gln Asn Pro  Thr Ile His His Gln  Thr Ala Ala 
    1610                 1615                 1620             


Ala Val  Val Pro Pro Pro Pro  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1625                 1630                 1635             


His Leu  Val Gln Gln Pro Asn  Ser His Gln Gln His  Ser Val Ala 
    1640                 1645                 1650             


His Val  Val Gly Pro Val His  Ala Val Thr Pro Gly  Ser His Ile 
    1655                 1660                 1665             


His Ser  Gln Thr Ala Gly His  His Leu Pro Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Pro Gly  Pro Ala Pro His His  His Pro Pro Pro His  Pro Ser Thr 
    1685                 1690                 1695             


Gly Leu  Gln Gly Leu Gln Ala  Gln His Gln His Val  Val Asn Ser 
    1700                 1705                 1710             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Ser Ser  Val Leu Ala 
    1715                 1720                 1725             


Ser Gly  His His Thr Thr Ser  Ala Gln Ala Leu His  His Pro Pro 
    1730                 1735                 1740             


His Gln  Gly Pro Pro Leu Phe  Pro Ser Ser Ala His  Pro Thr Val 
    1745                 1750                 1755             


Pro Pro  Tyr Pro Ser Gln Ala  Thr His His Thr Thr  Leu Gly Pro 
    1760                 1765                 1770             


Gly Pro  Gln His Gln Pro Ser  Gly Thr Gly Pro His  Cys Pro Leu 
    1775                 1780                 1785             


Pro Val  Thr Gly Pro His Leu  Gln Pro Gln Gly Pro  Asn Ser Ile 
    1790                 1795                 1800             


Pro Thr  Pro Thr Ala Ser Gly  Phe Cys Pro His Pro  Gly Ser Val 
    1805                 1810                 1815             


Ala Leu  Pro His Gly Val Gln  Gly Pro Gln Gln Ala  Ser Pro Val 
    1820                 1825                 1830             


Pro Gly  Gln Ile Pro Ile His  Arg Ala Gln Val Pro  Pro Thr Phe 
    1835                 1840                 1845             


Gln Asn  Asn Tyr His Gly Ser  Gly Trp His 
    1850                 1855             


<210>  1615
<211>  3737
<212>  DNA
<213>  Homosapiens

<400>  1615
tttcccttta tagcaccatt gaatcccagt cctaacagaa gtactgcgaa tcttgtggcc     60

tcattctgaa caaaagggat tagagaagaa aaatctcttg atataaggct tgaaagcaag    120

ggcaggcaat cttggttgtg aatattttct gatttttcca gaaatcaagc agaagattga    180

gctgctgatg tcagttaact ctgagaagtc gtcctcttca gaaaggccgg agcctcaaca    240

gaaagctcct ttagttcctc ctcctccacc gccaccacca ccaccaccgc cacctttgcc    300

agaccccaca cccccggagc cagaggagga gatcctggga tcagatgatg aggagcaaga    360

ggaccctgcg gactactgca aaggtggata tcatccagtg aaaattggag acctcttcaa    420

tggccggtat catgttatta gaaagcttgg atgggggcac ttctctactg tctggctgtg    480

ctgggatatg caggggaaaa gatttgttgc aatgaaagtt gtaaaaagtg cccagcatta    540

tacggagaca gccttggatg aaataaaatt gctcaaatgt gttcgagaaa gtgatcccag    600

tgacccaaac aaagacatgg tggtccagct cattgacgac ttcaagattt caggcatgaa    660

tgggatacat gtctgcatgg tcttcgaagt acttggccac catctcctca agtggatcat    720

caaatccaac tatcaaggcc tcccagtacg ttgtgtgaag agtatcattc gacaggtcct    780

tcaagggtta gattacttac acagtaagtg caagatcatt catactgaca taaagccgga    840

aaatatcttg atgtgtgtgg atgatgcata tgtgagaaga atggcagctg aggccactga    900

gtggcagaaa gcaggtgctc ctcctccttc agggtctgca gtgagtacgg ctccacagca    960

gaaacctata ggaaaaatat ctaaaaacaa aaagaaaaaa ctgaaaaaga aacagaagag   1020

gcaggctgag ttattggaga agcgcctgca ggagatagaa gaattggagc gagaagctga   1080

aaggaaaata atagaagaaa acatcacctc agctgcacct tccaatgacc aggatggcga   1140

atactgccca gaggtgaaac taaaaacaac aggattagag gaggcggctg aggcagagac   1200

tgcaaaggac aatggtgaag ctgaggacca ggaagagaaa gaagatgctg agaaagaaaa   1260

cattgaaaaa gatgaagatg atgtagatca ggaacttgcg aacatagacc ctacgtggat   1320

agaatcacct aaaaccaatg gccatattga gaatggccca ttctcactgg agcagcaact   1380

ggacgatgaa gatgatgatg aagaagactg cccaaatcct gaggaatata atcttgatga   1440

gccaaatgca gaaagtgatt acacatatag cagctcctat gaacaattca atggtgaatt   1500

gccaaatgga cgacataaaa ttcccgagtc acagttccca gagttttcca cctcgttgtt   1560

ctctggatcc ttagaacctg tggcctgcgg ctctgtgctt tctgagggat caccacttac   1620

tgagcaagag gagagcagtc catcccatga cagaagcaga acggtttcag cctccagtac   1680

tggggatttg ccaaaagcaa aaacccgggc agctgacttg ttggtgaatc ccctggatcc   1740

gcggaatgca gataaaatta gagtaaaaat tgctgacctg ggaaatgctt gttgggtgca   1800

taaacacttc acggaagaca tccagacgcg tcagtaccgc tccatagagg ttttaatagg   1860

agcggggtac agcacccctg cggacatctg gagcacggcg tgtatggcat ttgagctggc   1920

aacgggagat tatttgtttg aaccacattc tggggaagac tattccagag acgaagacca   1980

catagcccac atcatagagc tgctaggcag tattccaagg cactttgctc tatctggaaa   2040

atattctcgg gaattcttca atcgcagagg agaactgcga cacatcacca agctgaagcc   2100

ctggagcctc tttgatgtac ttgtggaaaa gtatggctgg ccccatgaag atgctgcaca   2160

gtttacagat ttcctgatcc cgatgttaga aatggttcca gaaaaacgag cctcagctgg   2220

cgaatgcctt cggcatcctt ggttgaattc ttagcaaatt ctaccaatat tgcattctga   2280

gctagcaaat gttcccagta cattggacct aaacggtgac tctcattctt taacaggatt   2340

acaagtgagc tggcttcatc ctcagacctt tattttgctt tgaggtactg ttgtttgaca   2400

ttttgctttt tgtgcactgt gatcctgggg aagggtagtc ttttgtcttc agctaagtag   2460

tttactgacc attttcttct ggaaacaata acatgtctct aagcattgtt tcttgtgttg   2520

tgtgacattc aaatgtcatt tttttgaatg aaaaatactt tcccctttgt gttttggcag   2580

gttttgtaac tatttatgaa gaaatatttt agctgagtac tatataattt acaatcttaa   2640

gaaattatca agttggaacc aagaaatagc aaggaaatgt acaattttat cttctggcaa   2700

agggacatca ttcctgtatt atagtgtatg taaatgcacc ctgtaaatgt tactttccat   2760

taaatatggg agggggactc aaatttcaga aaagctacca agtcttgagt gctttgtagc   2820

ctatgttgca tgtagcggac tttaactgct ccaaggagtt gtgcaaactt ttcattccat   2880

aacagtcttt tcacattgga ttttaaacaa agtggctctg ggttataaga tgtcattctc   2940

tatatggcac tttaaaggaa gaaaagatat gtttctcatt ctaaaatatg cattataatt   3000

tagcagtccc atttgtgatt ttgcatattt ttaaaagtac ttttaaagaa gagcaatttc   3060

cctttaaaaa tgtgatggct cagtaccatg tcatgttgcc tcctctgggc gctgtaagtt   3120

aagctctaca tagattaaat tggagaaacg tgttaattgt gtggaatgaa aaaatacata   3180

tatttttgga aaagcatgat catgcttgtc tagaacacaa ggtatggtat atacaatttg   3240

cagtgcagtg ggcagaatac ttctcacagc tcaaagataa cagtgatcac attcattcca   3300

taggtagctt tacgtgtggc tacaacaaat tttactagct ttttcattgt ctttccatga   3360

aacgaagttg agaaaatgat tttccctttg caggttgcac acagttttgt ttatgcattt   3420

ccttaaaatt aattgtagac tccaggatac aaaccatagt aggcaataca attttagaat   3480

gtaatatata gaggtatatt tagcctcttt tagaagtcag tggattgaat gtctttttat   3540

tttaaatttt acattcatta aggtgcctcg tttttgactt tgtccattaa catttatcca   3600

tatgcctttg caataactag attgtgaaaa gctaacaagt gttgtaacaa taatccattg   3660

tttgaggtgc ttgcagttgt cttaaaaatt aaagtgtttt ggtttttttt tttccaaaaa   3720

aaaaaaaaaa aaaaaaa                                                  3737


<210>  1616
<211>  688
<212>  PRT
<213>  Homosapiens

<400>  1616

Met Ser Val Asn Ser Glu Lys Ser Ser Ser Ser Glu Arg Pro Glu Pro 
1               5                   10                  15      


Gln Gln Lys Ala Pro Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Asp Pro Thr Pro Pro Glu Pro Glu Glu Glu 
        35                  40                  45              


Ile Leu Gly Ser Asp Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys 
    50                  55                  60                  


Lys Gly Gly Tyr His Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg 
65                  70                  75                  80  


Tyr His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp 
                85                  90                  95      


Leu Cys Trp Asp Met Gln Gly Lys Arg Phe Val Ala Met Lys Val Val 
            100                 105                 110         


Lys Ser Ala Gln His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu 
        115                 120                 125             


Leu Lys Cys Val Arg Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met 
    130                 135                 140                 


Val Val Gln Leu Ile Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile 
145                 150                 155                 160 


His Val Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp 
                165                 170                 175     


Ile Ile Lys Ser Asn Tyr Gln Gly Leu Pro Val Arg Cys Val Lys Ser 
            180                 185                 190         


Ile Ile Arg Gln Val Leu Gln Gly Leu Asp Tyr Leu His Ser Lys Cys 
        195                 200                 205             


Lys Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Met Cys Val 
    210                 215                 220                 


Asp Asp Ala Tyr Val Arg Arg Met Ala Ala Glu Ala Thr Glu Trp Gln 
225                 230                 235                 240 


Lys Ala Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro 
                245                 250                 255     


Gln Gln Lys Pro Ile Gly Lys Ile Ser Lys Asn Lys Lys Lys Lys Leu 
            260                 265                 270         


Lys Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Leu Gln 
        275                 280                 285             


Glu Ile Glu Glu Leu Glu Arg Glu Ala Glu Arg Lys Ile Ile Glu Glu 
    290                 295                 300                 


Asn Ile Thr Ser Ala Ala Pro Ser Asn Asp Gln Asp Gly Glu Tyr Cys 
305                 310                 315                 320 


Pro Glu Val Lys Leu Lys Thr Thr Gly Leu Glu Glu Ala Ala Glu Ala 
                325                 330                 335     


Glu Thr Ala Lys Asp Asn Gly Glu Ala Glu Asp Gln Glu Glu Lys Glu 
            340                 345                 350         


Asp Ala Glu Lys Glu Asn Ile Glu Lys Asp Glu Asp Asp Val Asp Gln 
        355                 360                 365             


Glu Leu Ala Asn Ile Asp Pro Thr Trp Ile Glu Ser Pro Lys Thr Asn 
    370                 375                 380                 


Gly His Ile Glu Asn Gly Pro Phe Ser Leu Glu Gln Gln Leu Asp Asp 
385                 390                 395                 400 


Glu Asp Asp Asp Glu Glu Asp Cys Pro Asn Pro Glu Glu Tyr Asn Leu 
                405                 410                 415     


Asp Glu Pro Asn Ala Glu Ser Asp Tyr Thr Tyr Ser Ser Ser Tyr Glu 
            420                 425                 430         


Gln Phe Asn Gly Glu Leu Pro Asn Gly Arg His Lys Ile Pro Glu Ser 
        435                 440                 445             


Gln Phe Pro Glu Phe Ser Thr Ser Leu Phe Ser Gly Ser Leu Glu Pro 
    450                 455                 460                 


Val Ala Cys Gly Ser Val Leu Ser Glu Gly Ser Pro Leu Thr Glu Gln 
465                 470                 475                 480 


Glu Glu Ser Ser Pro Ser His Asp Arg Ser Arg Thr Val Ser Ala Ser 
                485                 490                 495     


Ser Thr Gly Asp Leu Pro Lys Ala Lys Thr Arg Ala Ala Asp Leu Leu 
            500                 505                 510         


Val Asn Pro Leu Asp Pro Arg Asn Ala Asp Lys Ile Arg Val Lys Ile 
        515                 520                 525             


Ala Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp 
    530                 535                 540                 


Ile Gln Thr Arg Gln Tyr Arg Ser Ile Glu Val Leu Ile Gly Ala Gly 
545                 550                 555                 560 


Tyr Ser Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu 
                565                 570                 575     


Leu Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Asp Tyr 
            580                 585                 590         


Ser Arg Asp Glu Asp His Ile Ala His Ile Ile Glu Leu Leu Gly Ser 
        595                 600                 605             


Ile Pro Arg His Phe Ala Leu Ser Gly Lys Tyr Ser Arg Glu Phe Phe 
    610                 615                 620                 


Asn Arg Arg Gly Glu Leu Arg His Ile Thr Lys Leu Lys Pro Trp Ser 
625                 630                 635                 640 


Leu Phe Asp Val Leu Val Glu Lys Tyr Gly Trp Pro His Glu Asp Ala 
                645                 650                 655     


Ala Gln Phe Thr Asp Phe Leu Ile Pro Met Leu Glu Met Val Pro Glu 
            660                 665                 670         


Lys Arg Ala Ser Ala Gly Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
        675                 680                 685             


<210>  1617
<211>  3671
<212>  DNA
<213>  Homosapiens

<400>  1617
ggcggagcga gtggaggctg cagcccagct cgtctcggcg cccgcgtcgc cgtcgcgaag     60

ccccccgccc cgcttccgcc gcgtcggaat gagctcccgg aaagtgctgg ccattcaggc    120

ccgaaagcgg aggccgaaaa gagagaaaca tccgaaaaag ccggagcctc aacagaaagc    180

tcctttagtt cctcctcctc caccgccacc accaccacca ccgccacctt tgccagaccc    240

cacacccccg gagccagagg aggagatcct gggatcagat gatgaggagc aagaggaccc    300

tgcggactac tgcaaaggtg gatatcatcc agtgaaaatt ggagacctct tcaatggccg    360

gtatcatgtt attagaaagc ttggatgggg gcacttctct actgtctggc tgtgctggga    420

tatgcagggg aaaagatttg ttgcaatgaa agttgtaaaa agtgcccagc attatacgga    480

gacagccttg gatgaaataa aattgctcaa atgtgttcga gaaagtgatc ccagtgaccc    540

aaacaaagac atggtggtcc agctcattga cgacttcaag atttcaggca tgaatgggat    600

acatgtctgc atggtcttcg aagtacttgg ccaccatctc ctcaagtgga tcatcaaatc    660

caactatcaa ggcctcccag tacgttgtgt gaagagtatc attcgacagg tccttcaagg    720

gttagattac ttacacagta agtgcaagat cattcatact gacataaagc cggaaaatat    780

cttgatgtgt gtggatgatg catatgtgag aagaatggca gctgaggcca ctgagtggca    840

gaaagcaggt gctcctcctc cttcagggtc tgcagtgagt acggctccac agcagaaacc    900

tataggaaaa atatctaaaa acaaaaagaa aaaactgaaa aagaaacaga agaggcaggc    960

tgagttattg gagaagcgcc tgcaggagat agaagaattg gagcgagaag ctgaaaggaa   1020

aataatagaa gaaaacatca cctcagctgc accttccaat gaccaggatg gcgaatactg   1080

cccagaggtg aaactaaaaa caacaggatt agaggaggcg gctgaggcag agactgcaaa   1140

ggacaatggt gaagctgagg accaggaaga gaaagaagat gctgagaaag aaaacattga   1200

aaaagatgaa gatgatgtag atcaggaact tgcgaacata gaccctacgt ggatagaatc   1260

acctaaaacc aatggccata ttgagaatgg cccattctca ctggagcagc aactggacga   1320

tgaagatgat gatgaagaag actgcccaaa tcctgaggaa tataatcttg atgagccaaa   1380

tgcagaaagt gattacacat atagcagctc ctatgaacaa ttcaatggtg aattgccaaa   1440

tggacgacat aaaattcccg agtcacagtt cccagagttt tccacctcgt tgttctctgg   1500

atccttagaa cctgtggcct gcggctctgt gctttctgag ggatcaccac ttactgagca   1560

agaggagagc agtccatccc atgacagaag cagaacggtt tcagcctcca gtactgggga   1620

tttgccaaaa gcaaaaaccc gggcagctga cttgttggtg aatcccctgg atccgcggaa   1680

tgcagataaa attagagtaa aaattgctga cctgggaaat gcttgttggg tgcataaaca   1740

cttcacggaa gacatccaga cgcgtcagta ccgctccata gaggttttaa taggagcggg   1800

gtacagcacc cctgcggaca tctggagcac ggcgtgtatg gcatttgagc tggcaacggg   1860

agattatttg tttgaaccac attctgggga agactattcc agagacgaag accacatagc   1920

ccacatcata gagctgctag gcagtattcc aaggcacttt gctctatctg gaaaatattc   1980

tcgggaattc ttcaatcgca gaggagaact gcgacacatc accaagctga agccctggag   2040

cctctttgat gtacttgtgg aaaagtatgg ctggccccat gaagatgctg cacagtttac   2100

agatttcctg atcccgatgt tagaaatggt tccagaaaaa cgagcctcag ctggcgaatg   2160

ccttcggcat ccttggttga attcttagca aattctacca atattgcatt ctgagctagc   2220

aaatgttccc agtacattgg acctaaacgg tgactctcat tctttaacag gattacaagt   2280

gagctggctt catcctcaga cctttatttt gctttgaggt actgttgttt gacattttgc   2340

tttttgtgca ctgtgatcct ggggaagggt agtcttttgt cttcagctaa gtagtttact   2400

gaccattttc ttctggaaac aataacatgt ctctaagcat tgtttcttgt gttgtgtgac   2460

attcaaatgt catttttttg aatgaaaaat actttcccct ttgtgttttg gcaggttttg   2520

taactattta tgaagaaata ttttagctga gtactatata atttacaatc ttaagaaatt   2580

atcaagttgg aaccaagaaa tagcaaggaa atgtacaatt ttatcttctg gcaaagggac   2640

atcattcctg tattatagtg tatgtaaatg caccctgtaa atgttacttt ccattaaata   2700

tgggaggggg actcaaattt cagaaaagct accaagtctt gagtgctttg tagcctatgt   2760

tgcatgtagc ggactttaac tgctccaagg agttgtgcaa acttttcatt ccataacagt   2820

cttttcacat tggattttaa acaaagtggc tctgggttat aagatgtcat tctctatatg   2880

gcactttaaa ggaagaaaag atatgtttct cattctaaaa tatgcattat aatttagcag   2940

tcccatttgt gattttgcat atttttaaaa gtacttttaa agaagagcaa tttcccttta   3000

aaaatgtgat ggctcagtac catgtcatgt tgcctcctct gggcgctgta agttaagctc   3060

tacatagatt aaattggaga aacgtgttaa ttgtgtggaa tgaaaaaata catatatttt   3120

tggaaaagca tgatcatgct tgtctagaac acaaggtatg gtatatacaa tttgcagtgc   3180

agtgggcaga atacttctca cagctcaaag ataacagtga tcacattcat tccataggta   3240

gctttacgtg tggctacaac aaattttact agctttttca ttgtctttcc atgaaacgaa   3300

gttgagaaaa tgattttccc tttgcaggtt gcacacagtt ttgtttatgc atttccttaa   3360

aattaattgt agactccagg atacaaacca tagtaggcaa tacaatttta gaatgtaata   3420

tatagaggta tatttagcct cttttagaag tcagtggatt gaatgtcttt ttattttaaa   3480

ttttacattc attaaggtgc ctcgtttttg actttgtcca ttaacattta tccatatgcc   3540

tttgcaataa ctagattgtg aaaagctaac aagtgttgta acaataatcc attgtttgag   3600

gtgcttgcag ttgtcttaaa aattaaagtg ttttggtttt tttttttcca aaaaaaaaaa   3660

aaaaaaaaaa a                                                        3671


<210>  1618
<211>  699
<212>  PRT
<213>  Homosapiens

<400>  1618

Met Ser Ser Arg Lys Val Leu Ala Ile Gln Ala Arg Lys Arg Arg Pro 
1               5                   10                  15      


Lys Arg Glu Lys His Pro Lys Lys Pro Glu Pro Gln Gln Lys Ala Pro 
            20                  25                  30          


Leu Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu 
        35                  40                  45              


Pro Asp Pro Thr Pro Pro Glu Pro Glu Glu Glu Ile Leu Gly Ser Asp 
    50                  55                  60                  


Asp Glu Glu Gln Glu Asp Pro Ala Asp Tyr Cys Lys Gly Gly Tyr His 
65                  70                  75                  80  


Pro Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr His Val Ile Arg 
                85                  90                  95      


Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu Cys Trp Asp Met 
            100                 105                 110         


Gln Gly Lys Arg Phe Val Ala Met Lys Val Val Lys Ser Ala Gln His 
        115                 120                 125             


Tyr Thr Glu Thr Ala Leu Asp Glu Ile Lys Leu Leu Lys Cys Val Arg 
    130                 135                 140                 


Glu Ser Asp Pro Ser Asp Pro Asn Lys Asp Met Val Val Gln Leu Ile 
145                 150                 155                 160 


Asp Asp Phe Lys Ile Ser Gly Met Asn Gly Ile His Val Cys Met Val 
                165                 170                 175     


Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile Ile Lys Ser Asn 
            180                 185                 190         


Tyr Gln Gly Leu Pro Val Arg Cys Val Lys Ser Ile Ile Arg Gln Val 
        195                 200                 205             


Leu Gln Gly Leu Asp Tyr Leu His Ser Lys Cys Lys Ile Ile His Thr 
    210                 215                 220                 


Asp Ile Lys Pro Glu Asn Ile Leu Met Cys Val Asp Asp Ala Tyr Val 
225                 230                 235                 240 


Arg Arg Met Ala Ala Glu Ala Thr Glu Trp Gln Lys Ala Gly Ala Pro 
                245                 250                 255     


Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln Gln Lys Pro Ile 
            260                 265                 270         


Gly Lys Ile Ser Lys Asn Lys Lys Lys Lys Leu Lys Lys Lys Gln Lys 
        275                 280                 285             


Arg Gln Ala Glu Leu Leu Glu Lys Arg Leu Gln Glu Ile Glu Glu Leu 
    290                 295                 300                 


Glu Arg Glu Ala Glu Arg Lys Ile Ile Glu Glu Asn Ile Thr Ser Ala 
305                 310                 315                 320 


Ala Pro Ser Asn Asp Gln Asp Gly Glu Tyr Cys Pro Glu Val Lys Leu 
                325                 330                 335     


Lys Thr Thr Gly Leu Glu Glu Ala Ala Glu Ala Glu Thr Ala Lys Asp 
            340                 345                 350         


Asn Gly Glu Ala Glu Asp Gln Glu Glu Lys Glu Asp Ala Glu Lys Glu 
        355                 360                 365             


Asn Ile Glu Lys Asp Glu Asp Asp Val Asp Gln Glu Leu Ala Asn Ile 
    370                 375                 380                 


Asp Pro Thr Trp Ile Glu Ser Pro Lys Thr Asn Gly His Ile Glu Asn 
385                 390                 395                 400 


Gly Pro Phe Ser Leu Glu Gln Gln Leu Asp Asp Glu Asp Asp Asp Glu 
                405                 410                 415     


Glu Asp Cys Pro Asn Pro Glu Glu Tyr Asn Leu Asp Glu Pro Asn Ala 
            420                 425                 430         


Glu Ser Asp Tyr Thr Tyr Ser Ser Ser Tyr Glu Gln Phe Asn Gly Glu 
        435                 440                 445             


Leu Pro Asn Gly Arg His Lys Ile Pro Glu Ser Gln Phe Pro Glu Phe 
    450                 455                 460                 


Ser Thr Ser Leu Phe Ser Gly Ser Leu Glu Pro Val Ala Cys Gly Ser 
465                 470                 475                 480 


Val Leu Ser Glu Gly Ser Pro Leu Thr Glu Gln Glu Glu Ser Ser Pro 
                485                 490                 495     


Ser His Asp Arg Ser Arg Thr Val Ser Ala Ser Ser Thr Gly Asp Leu 
            500                 505                 510         


Pro Lys Ala Lys Thr Arg Ala Ala Asp Leu Leu Val Asn Pro Leu Asp 
        515                 520                 525             


Pro Arg Asn Ala Asp Lys Ile Arg Val Lys Ile Ala Asp Leu Gly Asn 
    530                 535                 540                 


Ala Cys Trp Val His Lys His Phe Thr Glu Asp Ile Gln Thr Arg Gln 
545                 550                 555                 560 


Tyr Arg Ser Ile Glu Val Leu Ile Gly Ala Gly Tyr Ser Thr Pro Ala 
                565                 570                 575     


Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu Leu Ala Thr Gly Asp 
            580                 585                 590         


Tyr Leu Phe Glu Pro His Ser Gly Glu Asp Tyr Ser Arg Asp Glu Asp 
        595                 600                 605             


His Ile Ala His Ile Ile Glu Leu Leu Gly Ser Ile Pro Arg His Phe 
    610                 615                 620                 


Ala Leu Ser Gly Lys Tyr Ser Arg Glu Phe Phe Asn Arg Arg Gly Glu 
625                 630                 635                 640 


Leu Arg His Ile Thr Lys Leu Lys Pro Trp Ser Leu Phe Asp Val Leu 
                645                 650                 655     


Val Glu Lys Tyr Gly Trp Pro His Glu Asp Ala Ala Gln Phe Thr Asp 
            660                 665                 670         


Phe Leu Ile Pro Met Leu Glu Met Val Pro Glu Lys Arg Ala Ser Ala 
        675                 680                 685             


Gly Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
    690                 695                 


<210>  1619
<211>  3484
<212>  DNA
<213>  Homosapiens

<400>  1619
gtgcgagccc ggccgccggt gagtcggctg gagcgcatct ggtcctccgc gcggaaagcg     60

ctgcttttgc ctggccgccc tagccgctgg ctcatccaag tggccttcgc cgctctcttg    120

cgtcccaacc agagcgctgg ccacctcgcc gcccagctca cgccgcgccc gcgctcccag    180

gctccgggtt ttcttaaatg ttttcttgga gccttaaaga tggagatgac agaaatgact    240

ggtgtgtcgc tgaaacgtgg ggcactggtt gtcgaagata atgacagtgg agtcccagtt    300

gaagagacaa aaaaacagaa gctgtcggaa tgcagtctaa ccaaaggtca agatgggcta    360

cagaatgact ttctgtccat cagtgaagac gtgcctcggc ctcctgacac tgtcagtact    420

gggaaaggtg gaaagaattc tgaggctcag ttggaagatg aggaagaaga ggaggaagat    480

ggactttcag aggagtgcga ggaggaggaa tcagagagtt ttgcagacat gatgaagcat    540

ggactcactg aggctgacgt aggcatcacc aagtttgtga gttctcatca agggttctcg    600

ggaatcttaa aagaaagata ctccgacttc gttgttcatg aaataggaaa agatggacgg    660

atcagccatt tgaatgactt gtccattcca gtggatgagg aggacccttc agaagacata    720

tttacagttt tgacagctga agaaaagcag cgattggaag agctccagct gttcaaaaat    780

aaggaaacca gtgttgccat tgaggttatc gaggacacca aagagaaaag aaccatcatc    840

catcaggcta tcaaatctct gtttccagga ttagagacaa aaacagagga tagggagggg    900

aagaaataca ttgtagccta ccacgcagct gggaaaaagg ctttggcaaa tccaagaaaa    960

cattcttggc caaaatctag gggaagttac tgccacttcg tactatataa ggaaaacaaa   1020

gacaccatgg atgctattaa tgtactctcc aaatacttaa gagtcaagcc aaatatattc   1080

tcctacatgg gaaccaaaga taaaagggct ataacagttc aagaaattgc tgttctcaaa   1140

ataactgcac aaagacttgc ccacctgaat aagtgcttga tgaactttaa gctagggaat   1200

ttcagctatc aaaaaaaccc actgaaattg ggagagcttc aaggaaacca cttcactgtt   1260

gttctcagaa atataacagg aactgatgac caagtacagc aagctatgaa ctctctcaag   1320

gagattggat ttattaacta ctatggaatg caaagatttg gaaccacagc tgtccctacg   1380

tatcaggttg gaagagctat actacaaaat tcctggacag aagtcatgga tttaatattg   1440

aaaccccgct ctggagctga aaagggctac ttggttaaat gcagagaaga atgggcaaag   1500

accaaagacc caactgctgc cctcagaaaa ctacctgtca aaaggtgtgt ggaagggcag   1560

ctgcttcgag gactttcaaa atatggaatg aagaatatag tctctgcatt tggcataata   1620

cccagaaata atcgcttaat gtatattcat agctaccaaa gctatgtgtg gaataacatg   1680

gtaagcaaga ggatagaaga ctatggacta aaacctgttc caggggacct cgttctcaaa   1740

ggagccacag ccacctatat tgaggaagat gatgttaata attactctat ccatgatgtg   1800

gtaatgccct tgcctggttt cgatgttatc tacccaaagc ataaaattca agaagcctac   1860

agggaaatgc tcacagctga caatcttgat attgacaaca tgagacacaa aattcgagat   1920

tattccttgt caggggccta ccgaaagatc attattcgtc ctcagaatgt tagctgggaa   1980

gtcgttgcat atgatgatcc caaaattcca cttttcaaca cagatgtgga caacctagaa   2040

gggaagacac caccagtttt tgcttctgaa ggcaaataca gggctctgaa aatggatttt   2100

tctctacccc cttctactta cgccaccatg gccattcgag aagtgctaaa aatggatacc   2160

agtatcaaga accagacgca gctgaataca acctggcttc gctgagcagt accttgtcca   2220

cagattagaa aacgtacaca agtgtttgct tcctggctcc ctgtgcattt ttgtcttagt   2280

tcagactcat atatggattt caaatctttg taataaaaat tatttgtatt tttaagtttt   2340

tattagctta aagaaataat ttgcaatatt tgtacatgta cacaaatcct gaggttctta   2400

attttagctc agaatataaa ttagtcaaaa tacacttcag gtgcttaaat cagagtaaaa   2460

tgtcagcttt acaataataa aaaaaggact ttggtttaaa gtagcaggtt taggttttgc   2520

tacattctca aaagacagca ggagtatttg acacatctgt gatggagtat acaacaatgc   2580

attttaagag caaatgcaac aaaacaaatc tggactatgg ataaataatt tgagagctgc   2640

cacccacaaa tataaataca gtactcatgc tgactgaaat aataagacat ctacaaattt   2700

ataaacaaaa agtgattgtc attatcctgc ttatgtacta gattcaggca agcattatag   2760

actttttggt tgcggtggct tttgcattta tattatcaat gccttgcagg aacgttgcat   2820

tgataggccc attttatttt tttatttttt ttttcgagac aggatctcac tctgtagcac   2880

aggctggatt gcagtgcaat cctgcaattc tcaatcttgc actgcagcct cgacctccca   2940

ggctccagtg actctcccac ctcagcctcc taagtagctg ggagtacagg cgcgcaccac   3000

cacgcctagc tgatttttgt atttttttgt agagacgggg gtttggccat gttgccgagg   3060

ctaactcctg ggattacagg catgagctgt gctggccggg tttttttttc ttgatgtaaa   3120

cgtgtacagc tgttttatta gttaaggtct aatttttact ctaggtgcct tttatgttca   3180

gaactctttc cactggactg gtatttgctc aaaaataaat aatggtagag aagaaaacta   3240

taaaaatgga caaggctttc ttctatcagt agcgtttacc ctttgtcacc agtggctttg   3300

gtatttccat gtctggcatt gcataaactt ctctggtgtg aaaggataaa tatgcctttc   3360

taaagttgta tatcaaaatt gtatcaattt ttattttcta tgatttctag aaacaaatgt   3420

aataaatatt tttaaaatct cctttctact ggttatgtaa ataaatcaaa taaatatatc   3480

aaaa                                                                3484


<210>  1620
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  1620

Met Glu Met Thr Glu Met Thr Gly Val Ser Leu Lys Arg Gly Ala Leu 
1               5                   10                  15      


Val Val Glu Asp Asn Asp Ser Gly Val Pro Val Glu Glu Thr Lys Lys 
            20                  25                  30          


Gln Lys Leu Ser Glu Cys Ser Leu Thr Lys Gly Gln Asp Gly Leu Gln 
        35                  40                  45              


Asn Asp Phe Leu Ser Ile Ser Glu Asp Val Pro Arg Pro Pro Asp Thr 
    50                  55                  60                  


Val Ser Thr Gly Lys Gly Gly Lys Asn Ser Glu Ala Gln Leu Glu Asp 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Glu Asp Gly Leu Ser Glu Glu Cys Glu Glu Glu 
                85                  90                  95      


Glu Ser Glu Ser Phe Ala Asp Met Met Lys His Gly Leu Thr Glu Ala 
            100                 105                 110         


Asp Val Gly Ile Thr Lys Phe Val Ser Ser His Gln Gly Phe Ser Gly 
        115                 120                 125             


Ile Leu Lys Glu Arg Tyr Ser Asp Phe Val Val His Glu Ile Gly Lys 
    130                 135                 140                 


Asp Gly Arg Ile Ser His Leu Asn Asp Leu Ser Ile Pro Val Asp Glu 
145                 150                 155                 160 


Glu Asp Pro Ser Glu Asp Ile Phe Thr Val Leu Thr Ala Glu Glu Lys 
                165                 170                 175     


Gln Arg Leu Glu Glu Leu Gln Leu Phe Lys Asn Lys Glu Thr Ser Val 
            180                 185                 190         


Ala Ile Glu Val Ile Glu Asp Thr Lys Glu Lys Arg Thr Ile Ile His 
        195                 200                 205             


Gln Ala Ile Lys Ser Leu Phe Pro Gly Leu Glu Thr Lys Thr Glu Asp 
    210                 215                 220                 


Arg Glu Gly Lys Lys Tyr Ile Val Ala Tyr His Ala Ala Gly Lys Lys 
225                 230                 235                 240 


Ala Leu Ala Asn Pro Arg Lys His Ser Trp Pro Lys Ser Arg Gly Ser 
                245                 250                 255     


Tyr Cys His Phe Val Leu Tyr Lys Glu Asn Lys Asp Thr Met Asp Ala 
            260                 265                 270         


Ile Asn Val Leu Ser Lys Tyr Leu Arg Val Lys Pro Asn Ile Phe Ser 
        275                 280                 285             


Tyr Met Gly Thr Lys Asp Lys Arg Ala Ile Thr Val Gln Glu Ile Ala 
    290                 295                 300                 


Val Leu Lys Ile Thr Ala Gln Arg Leu Ala His Leu Asn Lys Cys Leu 
305                 310                 315                 320 


Met Asn Phe Lys Leu Gly Asn Phe Ser Tyr Gln Lys Asn Pro Leu Lys 
                325                 330                 335     


Leu Gly Glu Leu Gln Gly Asn His Phe Thr Val Val Leu Arg Asn Ile 
            340                 345                 350         


Thr Gly Thr Asp Asp Gln Val Gln Gln Ala Met Asn Ser Leu Lys Glu 
        355                 360                 365             


Ile Gly Phe Ile Asn Tyr Tyr Gly Met Gln Arg Phe Gly Thr Thr Ala 
    370                 375                 380                 


Val Pro Thr Tyr Gln Val Gly Arg Ala Ile Leu Gln Asn Ser Trp Thr 
385                 390                 395                 400 


Glu Val Met Asp Leu Ile Leu Lys Pro Arg Ser Gly Ala Glu Lys Gly 
                405                 410                 415     


Tyr Leu Val Lys Cys Arg Glu Glu Trp Ala Lys Thr Lys Asp Pro Thr 
            420                 425                 430         


Ala Ala Leu Arg Lys Leu Pro Val Lys Arg Cys Val Glu Gly Gln Leu 
        435                 440                 445             


Leu Arg Gly Leu Ser Lys Tyr Gly Met Lys Asn Ile Val Ser Ala Phe 
    450                 455                 460                 


Gly Ile Ile Pro Arg Asn Asn Arg Leu Met Tyr Ile His Ser Tyr Gln 
465                 470                 475                 480 


Ser Tyr Val Trp Asn Asn Met Val Ser Lys Arg Ile Glu Asp Tyr Gly 
                485                 490                 495     


Leu Lys Pro Val Pro Gly Asp Leu Val Leu Lys Gly Ala Thr Ala Thr 
            500                 505                 510         


Tyr Ile Glu Glu Asp Asp Val Asn Asn Tyr Ser Ile His Asp Val Val 
        515                 520                 525             


Met Pro Leu Pro Gly Phe Asp Val Ile Tyr Pro Lys His Lys Ile Gln 
    530                 535                 540                 


Glu Ala Tyr Arg Glu Met Leu Thr Ala Asp Asn Leu Asp Ile Asp Asn 
545                 550                 555                 560 


Met Arg His Lys Ile Arg Asp Tyr Ser Leu Ser Gly Ala Tyr Arg Lys 
                565                 570                 575     


Ile Ile Ile Arg Pro Gln Asn Val Ser Trp Glu Val Val Ala Tyr Asp 
            580                 585                 590         


Asp Pro Lys Ile Pro Leu Phe Asn Thr Asp Val Asp Asn Leu Glu Gly 
        595                 600                 605             


Lys Thr Pro Pro Val Phe Ala Ser Glu Gly Lys Tyr Arg Ala Leu Lys 
    610                 615                 620                 


Met Asp Phe Ser Leu Pro Pro Ser Thr Tyr Ala Thr Met Ala Ile Arg 
625                 630                 635                 640 


Glu Val Leu Lys Met Asp Thr Ser Ile Lys Asn Gln Thr Gln Leu Asn 
                645                 650                 655     


Thr Thr Trp Leu Arg 
            660     


<210>  1621
<211>  288
<212>  DNA
<213>  Homosapiens

<400>  1621
atgaacacga ctgtgagccg ttggaccctc aagcaggaga ctcgaaccaa catggtgctg     60

gagctcgtaa ggtcactttt gaataggatg gactttgaag acttggggtt ggtagtagat    120

tgggaccacc acctgcctcc accggctgcc aagattgtgg ttgagaacct ctccaggaca    180

ctgcccactg atgactacac ttatgaggaa cacagacgag ataaggctcg aaaacagcag    240

cagcagcaga accgactgga gaacctccat ggagccatgt acacgtga                 288


<210>  1622
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  1622

Met Asn Thr Thr Val Ser Arg Trp Thr Leu Lys Gln Glu Thr Arg Thr 
1               5                   10                  15      


Asn Met Val Leu Glu Leu Val Arg Ser Leu Leu Asn Arg Met Asp Phe 
            20                  25                  30          


Glu Asp Leu Gly Leu Val Val Asp Trp Asp His His Leu Pro Pro Pro 
        35                  40                  45              


Ala Ala Lys Ile Val Val Glu Asn Leu Ser Arg Thr Leu Pro Thr Asp 
    50                  55                  60                  


Asp Tyr Thr Tyr Glu Glu His Arg Arg Asp Lys Ala Arg Lys Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Asn Arg Leu Glu Asn Leu His Gly Ala Met Tyr Thr 
                85                  90                  95  


<210>  1623
<211>  2991
<212>  DNA
<213>  Homosapiens

<400>  1623
cggccgttcc gacctccggt caggaggggg aggaacagag cacggccggc ggctgcacgg     60

gcagggcctc tctgggctga gaggaagaaa ccagtgagac atcgagagga agtcgctgtg    120

gcactcagtc ctacggcctc cgaggctggg tagtgagtgt gtcgctggcc ttagccagac    180

tccacaggcc acgctggctg cgaatggagc cgaggactcg cgcggaggcg agatgctacc    240

agccggcgag atcggcgcct ctcctgcagc cccgtgctgc tctgaaagtg gtgacgaaag    300

gaagaacctc gaggagaaaa gtgacataaa tgttacagtt cttattggaa gtaaacaagt    360

cagtgaaggt acagataatg gtgatctccc ttcttatgtg tctgcattca tagaaaagga    420

agttggaaat gaccttaaat ctttaaagaa acttgataaa ctcatagaac agaggacagt    480

aagtaaaatg cagttagaag aacaggtact tacaatttca tcagaaattc ctaaaagaat    540

tcgaagtgcc ttaaaaaatg cagaagaatc aaagcaattt cttaatcagt ttctggagca    600

ggaaactcat ctcttcagcg ccattaacag ccatttgctg actgcgcaac cttggatgga    660

cgatcttgga accatgatta gccagattga agagatcgaa cgtcatcttg cttaccttaa    720

atggatttca caaattgaag aactaagtga taacattcag caatatctga tgaccaataa    780

tgtaccggag gcagcctcca ctctagtgtc tatggcagaa cttgacatta aacttcagga    840

atcatcttgt actcatcttc ttggtttcat gagagccaca gttaaattct ggcataaaat    900

tctcaaggac aagcttacaa gtgattttga ggaaatttta gcacagcttc attggccatt    960

catcgcaccc cctcaatcac aaactgttgg cttaagtcga cctgccagtg ccccggagat   1020

atacagttac ctggagacac tgttttgtca gcttttgaaa ctacaaacct cagatgaatt   1080

acttactgag ccaaagcaac tcccagaaaa atactctctt cctgcctccc cttctgtcat   1140

cctgcccatc caggttatgc tgactcctct tcagaagagg ttcaggtatc acttcagagg   1200

gaaccggcag actaatgtgt taagcaagcc agaatggtac ttggctcaag tacttatgtg   1260

gattggaaac catactgaat ttctggatga gaagattcag ccaatattag acaaagtagg   1320

ctctttggta aacgcaaggc ttgaattttc tcggggcctt atgatgctgg ttcttgagaa   1380

gttagccact gatattcctt gtctgctata tgatgacaat ctcttctgtc atttggtgga   1440

tgaagtactc ttgtttgaaa gggagctaca cagtgttcat ggctatcctg gcacttttgc   1500

tagttgtatg catattctat cagaggaaac ctgttttcag agatggttga cggtggagag   1560

aaaatttgct cttcaaaaaa tggactcaat gctttcctca gaagctgcct gggtatcgca   1620

atataaggat atcactgacg tggatgaaat gaaagttcca gattgtgcag aaacttttat   1680

gactctactc ttggttataa ctgacaggta taaaaatctt cccacagctt cccgaaagct   1740

tcagttcctg gagttacaga aggacttagt agatgatttt aggatacgat taacacaagt   1800

gatgaaagaa gagactagag cttcccttgg ctttcgatac tgtgcaattc ttaatgctgt   1860

gaactacatc tcaacagtac tagcagattg ggctgacaat gttttctttc tacaacttca   1920

acaggctgca ctggaggtgt ttgcagagaa taatactctg agtaaattgc agctaggaca   1980

gctagcctct atggagagct ctgtctttga tgacatgatt aacctcttag aacgtttaaa   2040

gcatgatatg ttgacccgtc aagtagacca cgtttttaga gaagttaaag atgctgcaaa   2100

attgtataaa aaagaaagat ggttgtcctt gccatctcag tcagagcagg cagtgatgtc   2160

cctgtccagt tcggcttgcc cgttgctgct gacgttacga gaccatttac ttcagttgga   2220

gcagcagctt tgtttctcct tatttaaaat tttctggcaa atgcttgtag agaagctgga   2280

tgtatacatc taccaagaaa taattcttgc taatcacttc aatgaaggag gagcagccca   2340

gctgcagttt gatatgactc ggaatctttt ccctttgttt tctcactatt gcaagagacc   2400

agaaaattat tttaaacata taaaagaagc ctgtattgtt ttgaatttga acgtcggttc   2460

tgcactactg ctgaaagatg tactgcagtc agcttcaggg cagcttcctg ccacagcagc   2520

attaaatgaa gttggaattt acaaactggc tcaacaagat gttgagattc tacttaattt   2580

gaggacaaat tggcctaata ctggaaaata atgtctttca gaaaaaggtt tctttggttt   2640

ttgtttctaa gaaagaggaa gccaattgga tttcaagtta tatgatgaaa ttctgaatta   2700

atgaaactgg aaaactttat agaattactt attatcttgg atttatggtg ttattaaaat   2760

gctgaccata tttccttcat cctcttgttc ctaaggaaac aaaaacagaa aacgaaacaa   2820

tgaaaactca attctattta caagtataaa tgctgagtat gtctgttgaa gacgagcaga   2880

gatattaaat tataaccaac tttcaatttc ctgtgctaat taagggaaat tctgttgtgg   2940

ataatcaaac atagccaata aattttttta aaactccaaa aaaaaaaaaa a            2991


<210>  1624
<211>  792
<212>  PRT
<213>  Homosapiens

<400>  1624

Met Leu Pro Ala Gly Glu Ile Gly Ala Ser Pro Ala Ala Pro Cys Cys 
1               5                   10                  15      


Ser Glu Ser Gly Asp Glu Arg Lys Asn Leu Glu Glu Lys Ser Asp Ile 
            20                  25                  30          


Asn Val Thr Val Leu Ile Gly Ser Lys Gln Val Ser Glu Gly Thr Asp 
        35                  40                  45              


Asn Gly Asp Leu Pro Ser Tyr Val Ser Ala Phe Ile Glu Lys Glu Val 
    50                  55                  60                  


Gly Asn Asp Leu Lys Ser Leu Lys Lys Leu Asp Lys Leu Ile Glu Gln 
65                  70                  75                  80  


Arg Thr Val Ser Lys Met Gln Leu Glu Glu Gln Val Leu Thr Ile Ser 
                85                  90                  95      


Ser Glu Ile Pro Lys Arg Ile Arg Ser Ala Leu Lys Asn Ala Glu Glu 
            100                 105                 110         


Ser Lys Gln Phe Leu Asn Gln Phe Leu Glu Gln Glu Thr His Leu Phe 
        115                 120                 125             


Ser Ala Ile Asn Ser His Leu Leu Thr Ala Gln Pro Trp Met Asp Asp 
    130                 135                 140                 


Leu Gly Thr Met Ile Ser Gln Ile Glu Glu Ile Glu Arg His Leu Ala 
145                 150                 155                 160 


Tyr Leu Lys Trp Ile Ser Gln Ile Glu Glu Leu Ser Asp Asn Ile Gln 
                165                 170                 175     


Gln Tyr Leu Met Thr Asn Asn Val Pro Glu Ala Ala Ser Thr Leu Val 
            180                 185                 190         


Ser Met Ala Glu Leu Asp Ile Lys Leu Gln Glu Ser Ser Cys Thr His 
        195                 200                 205             


Leu Leu Gly Phe Met Arg Ala Thr Val Lys Phe Trp His Lys Ile Leu 
    210                 215                 220                 


Lys Asp Lys Leu Thr Ser Asp Phe Glu Glu Ile Leu Ala Gln Leu His 
225                 230                 235                 240 


Trp Pro Phe Ile Ala Pro Pro Gln Ser Gln Thr Val Gly Leu Ser Arg 
                245                 250                 255     


Pro Ala Ser Ala Pro Glu Ile Tyr Ser Tyr Leu Glu Thr Leu Phe Cys 
            260                 265                 270         


Gln Leu Leu Lys Leu Gln Thr Ser Asp Glu Leu Leu Thr Glu Pro Lys 
        275                 280                 285             


Gln Leu Pro Glu Lys Tyr Ser Leu Pro Ala Ser Pro Ser Val Ile Leu 
    290                 295                 300                 


Pro Ile Gln Val Met Leu Thr Pro Leu Gln Lys Arg Phe Arg Tyr His 
305                 310                 315                 320 


Phe Arg Gly Asn Arg Gln Thr Asn Val Leu Ser Lys Pro Glu Trp Tyr 
                325                 330                 335     


Leu Ala Gln Val Leu Met Trp Ile Gly Asn His Thr Glu Phe Leu Asp 
            340                 345                 350         


Glu Lys Ile Gln Pro Ile Leu Asp Lys Val Gly Ser Leu Val Asn Ala 
        355                 360                 365             


Arg Leu Glu Phe Ser Arg Gly Leu Met Met Leu Val Leu Glu Lys Leu 
    370                 375                 380                 


Ala Thr Asp Ile Pro Cys Leu Leu Tyr Asp Asp Asn Leu Phe Cys His 
385                 390                 395                 400 


Leu Val Asp Glu Val Leu Leu Phe Glu Arg Glu Leu His Ser Val His 
                405                 410                 415     


Gly Tyr Pro Gly Thr Phe Ala Ser Cys Met His Ile Leu Ser Glu Glu 
            420                 425                 430         


Thr Cys Phe Gln Arg Trp Leu Thr Val Glu Arg Lys Phe Ala Leu Gln 
        435                 440                 445             


Lys Met Asp Ser Met Leu Ser Ser Glu Ala Ala Trp Val Ser Gln Tyr 
    450                 455                 460                 


Lys Asp Ile Thr Asp Val Asp Glu Met Lys Val Pro Asp Cys Ala Glu 
465                 470                 475                 480 


Thr Phe Met Thr Leu Leu Leu Val Ile Thr Asp Arg Tyr Lys Asn Leu 
                485                 490                 495     


Pro Thr Ala Ser Arg Lys Leu Gln Phe Leu Glu Leu Gln Lys Asp Leu 
            500                 505                 510         


Val Asp Asp Phe Arg Ile Arg Leu Thr Gln Val Met Lys Glu Glu Thr 
        515                 520                 525             


Arg Ala Ser Leu Gly Phe Arg Tyr Cys Ala Ile Leu Asn Ala Val Asn 
    530                 535                 540                 


Tyr Ile Ser Thr Val Leu Ala Asp Trp Ala Asp Asn Val Phe Phe Leu 
545                 550                 555                 560 


Gln Leu Gln Gln Ala Ala Leu Glu Val Phe Ala Glu Asn Asn Thr Leu 
                565                 570                 575     


Ser Lys Leu Gln Leu Gly Gln Leu Ala Ser Met Glu Ser Ser Val Phe 
            580                 585                 590         


Asp Asp Met Ile Asn Leu Leu Glu Arg Leu Lys His Asp Met Leu Thr 
        595                 600                 605             


Arg Gln Val Asp His Val Phe Arg Glu Val Lys Asp Ala Ala Lys Leu 
    610                 615                 620                 


Tyr Lys Lys Glu Arg Trp Leu Ser Leu Pro Ser Gln Ser Glu Gln Ala 
625                 630                 635                 640 


Val Met Ser Leu Ser Ser Ser Ala Cys Pro Leu Leu Leu Thr Leu Arg 
                645                 650                 655     


Asp His Leu Leu Gln Leu Glu Gln Gln Leu Cys Phe Ser Leu Phe Lys 
            660                 665                 670         


Ile Phe Trp Gln Met Leu Val Glu Lys Leu Asp Val Tyr Ile Tyr Gln 
        675                 680                 685             


Glu Ile Ile Leu Ala Asn His Phe Asn Glu Gly Gly Ala Ala Gln Leu 
    690                 695                 700                 


Gln Phe Asp Met Thr Arg Asn Leu Phe Pro Leu Phe Ser His Tyr Cys 
705                 710                 715                 720 


Lys Arg Pro Glu Asn Tyr Phe Lys His Ile Lys Glu Ala Cys Ile Val 
                725                 730                 735     


Leu Asn Leu Asn Val Gly Ser Ala Leu Leu Leu Lys Asp Val Leu Gln 
            740                 745                 750         


Ser Ala Ser Gly Gln Leu Pro Ala Thr Ala Ala Leu Asn Glu Val Gly 
        755                 760                 765             


Ile Tyr Lys Leu Ala Gln Gln Asp Val Glu Ile Leu Leu Asn Leu Arg 
    770                 775                 780                 


Thr Asn Trp Pro Asn Thr Gly Lys 
785                 790         


<210>  1625
<211>  382
<212>  DNA
<213>  Homosapiens

<400>  1625
taattgcgtg gaggacccct atgacgtgga tagcgtctat aatggttacg atctgctgca     60

tatttaccgc cttgaactcg aacaccacca ggatctgtaa catttgctgc ctccgcaccc    120

tcttctcctt caacaacatc aaactccaca gtctcttcat ctcctacact gcgaaggtac    180

ttcctggggt tattctttat ggcagtctgg tgtacaaata catcttcctt ggtgtcattc    240

ctgttgatga aaccatatcc gttccttaca ttgaaccatt ttactgttcc caaaaccttc    300

gttgcggtga tggagactgg ggccggctgc ggcagctgcg gctcctcccg tggtatgacg    360

gtaactaggc cggcagcggc gg                                             382


<210>  1626
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  1626

Met Thr Trp Ile Ala Ser Ile Met Val Thr Ile Cys Cys Ile Phe Thr 
1               5                   10                  15      


Ala Leu Asn Ser Asn Thr Thr Arg Ile Cys Asn Ile Cys Cys Leu Arg 
            20                  25                  30          


Thr Leu Phe Ser Phe Asn Asn Ile Lys Leu His Ser Leu Phe Ile Ser 
        35                  40                  45              


Tyr Thr Ala Lys Val Leu Pro Gly Val Ile Leu Tyr Gly Ser Leu Val 
    50                  55                  60                  


Tyr Lys Tyr Ile Phe Leu Gly Val Ile Pro Val Asp Glu Thr Ile Ser 
65                  70                  75                  80  


Val Pro Tyr Ile Glu Pro Phe Tyr Cys Ser Gln Asn Leu Arg Cys Gly 
                85                  90                  95      


Asp Gly Asp Trp Gly Arg Leu Arg Gln Leu Arg Leu Leu Pro Trp Tyr 
            100                 105                 110         


Asp Gly Asn 
        115 


<210>  1627
<211>  2045
<212>  DNA
<213>  Homosapiens

<400>  1627
gggaccttta gagagttagc aataaggctg gagaaggaaa agccggcgcg cccgcggccc     60

gcgcgatttc ccgccgagcc cgcgtccccg gcggcgggcg ggctccgggg gcgcccgggc    120

cgcggcggcg gcggcggcgc gagctgcgcc tccgggccgg tgaatcatcc cggcagacac    180

caagagccgc ggcagcagag aggagcgctg aaacatggct gaagcggcca cgggctttct    240

ggagcagctc aagtcctgca tagtttggtc ttggacgtat ctgtggaccg tgtggttctt    300

catcgtgcta ttcctggtct acatcctgcg ggtgcctttg aaaatcaacg acaacttgag    360

cacagtgagc atgtttttga acacattaac accgaagttc tacgtggccc taacaggcac    420

ttcctcacta atatcagggc ttattttgat atttgaatgg tggtattttc gcaaatacgg    480

aacttcattc attgaacaag tctcagtaag ccacttgcgc ccccttctgg gaggggttga    540

caacaactct tccaacaatt ctaattccag taacggggac tcagattcca ataggcaaag    600

tgtctcagaa tgcaaagtat ggcgaaatcc actaaattta tttaggggtg ctgaatacaa    660

tcggtatact tgggtgacag gacgagagcc tcttacttac tatgacatga atctctctgc    720

ccaagaccac cagacattct ttacttgtga ctcggaccat ctgcgtcccg cagatgcaat    780

aatgcagaaa gcctggagag agagaaaccc ccaagctagg atttctgcag ctcatgaagc    840

cttggagata aatgagtgtg caactgctta tattctcttg gctgaagagg aagcaacaac    900

cattgctgaa gcagaaaaat tatttaagca ggccctgaag gctggagatg gctgttaccg    960

acgctctcag cagctacaac atcatggatc ccagtatgaa gcccaacata gacgagacac   1020

caatgtcttg gtgtacatca aaagaaggct agcaatgtgt gccagaagac tcgggaggac   1080

cagggaagca gtgaaaatga tgagagattt aatgaaggag ttcccccttc tgagtatgtt   1140

caatatccat gaaaaccttt tagaagccct tctggaacta caagcatatg ctgatgttca   1200

ggcagtctta gcaaagtatg atgatataag cttaccaaag tcagcaacaa tatgctacac   1260

agctgctttg ctcaaagcaa gagctgtctc tgacaaattc tctcctgagg ctgcatctcg   1320

gcgggggctg agcacagcag agatgaatgc agtagaggcc attcatagag ctgtggaatt   1380

caatcctcat gtgccaaaat acctactaga aatgaaaagc ttaatcctac ccccagaaca   1440

tatcctgaag agaggagaca gtgaagcaat agcatatgca ttctttcatc ttgcacactg   1500

gaagagagtg gaaggggctt tgaatctttt gcattgtacg tgggaaggca cttttcggat   1560

gatcccttat cccttggaaa aggggcacct attttatcct tacccaatct gtacagaaac   1620

agcagaccga gagctgcttc catctttcca tgaagtctca gtttacccaa agaaggagct   1680

tcccttcttt attctcttta ctgctggatt atgttccttc acagccatgc tggccctcct   1740

gacacatcag ttcccggaac ttatgggggt cttcgcaaaa gctttcctca gcactttgtt   1800

tgccccctta aactttgtca tggagaaagt ggagagcatc ctcccatcca gtctgtggca   1860

ccagctaaca cggatctgag agaagccctg tcctccactc acctcacccg ccgctgccac   1920

catctcctct gtgccaactc cttgtggacc gcaagaaagc atgactttga aaaagggaag   1980

ccattccgag attttaaaat gttcatggac tattccatat taaaagctgt ttttgttgta   2040

caaaa                                                               2045


<210>  1628
<211>  554
<212>  PRT
<213>  Homosapiens

<400>  1628

Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile 
1               5                   10                  15      


Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu 
            20                  25                  30          


Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu 
        35                  40                  45              


Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val 
    50                  55                  60                  


Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe 
65                  70                  75                  80  


Glu Trp Trp Tyr Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val 
                85                  90                  95      


Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser 
            100                 105                 110         


Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln 
        115                 120                 125             


Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg 
    130                 135                 140                 


Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu 
145                 150                 155                 160 


Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe 
                165                 170                 175     


Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys 
            180                 185                 190         


Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu 
        195                 200                 205             


Ala Leu Glu Ile Asn Glu Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu 
    210                 215                 220                 


Glu Glu Ala Thr Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala 
225                 230                 235                 240 


Leu Lys Ala Gly Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His 
                245                 250                 255     


His Gly Ser Gln Tyr Glu Ala Gln His Arg Arg Asp Thr Asn Val Leu 
            260                 265                 270         


Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg Arg Leu Gly Arg 
        275                 280                 285             


Thr Arg Glu Ala Val Lys Met Met Arg Asp Leu Met Lys Glu Phe Pro 
    290                 295                 300                 


Leu Leu Ser Met Phe Asn Ile His Glu Asn Leu Leu Glu Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala Lys Tyr Asp 
                325                 330                 335     


Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr Ala Ala Leu 
            340                 345                 350         


Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala Ser 
        355                 360                 365             


Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala Ile His 
    370                 375                 380                 


Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu Met 
385                 390                 395                 400 


Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg Gly Asp Ser 
                405                 410                 415     


Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg Val 
            420                 425                 430         


Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe Arg 
        435                 440                 445             


Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr Pro 
    450                 455                 460                 


Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Phe His Glu 
465                 470                 475                 480 


Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile Leu Phe Thr 
                485                 490                 495     


Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu Thr His Gln 
            500                 505                 510         


Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Phe Leu Ser Thr Leu 
        515                 520                 525             


Phe Ala Pro Leu Asn Phe Val Met Glu Lys Val Glu Ser Ile Leu Pro 
    530                 535                 540                 


Ser Ser Leu Trp His Gln Leu Thr Arg Ile 
545                 550                 


<210>  1629
<211>  2970
<212>  DNA
<213>  Homosapiens

<400>  1629
gggaccttta gagagttagc aataaggctg gagaaggaaa agccggcgcg cccgcggccc     60

gcgcgatttc ccgccgagcc cgcgtccccg gcggcgggcg ggctccgggg gcgcccgggc    120

cgcggcggcg gcggcggcgc gagctgcgcc tccgggccgg tgaatcatcc cggcagacac    180

caagagccgc ggcagcagag aggagcgctg aaacatggct gaagcggcca cgggctttct    240

ggagcagctc aagtcctgca tagtttggtc ttggacgtat ctgtggaccg tgtggttctt    300

catcgtgcta ttcctggtct acatcctgcg ggtgcctttg aaaatcaacg acaacttgag    360

cacagtgagc atgtttttga acacattaac accgaagttc tacgtggccc taacaggcac    420

ttcctcacta atatcagggc ttattttgat atttgaatgg tggtattttc gcaaatacgg    480

aacttcattc attgaacaag tctcagtaag ccacttgcgc ccccttctgg gaggggttga    540

caacaactct tccaacaatt ctaattccag taacggggac tcagattcca ataggcaaag    600

tgtctcagaa tgcaaagtat ggcgaaatcc actaaattta tttaggggtg ctgaatacaa    660

tcggtatact tgggtgacag gacgagagcc tcttacttac tatgacatga atctctctgc    720

ccaagaccac cagacattct ttacttgtga ctcggaccat ctgcgtcccg cagatgcaat    780

aatgcagaaa gcctggagag agagaaaccc ccaagctagg atttctgcag ctcatgaagc    840

cttggagata aatgaaatta ggtccagagt tgaagttccc ctaattgctt cctctaccat    900

ctgggagata aaattgttac caaagtgtgc aactgcttat attctcttgg ctgaagagga    960

agcaacaacc attgctgaag cagaaaaatt atttaagcag gccctgaagg ctggagatgg   1020

ctgttaccga cgctctcagc agctacaaca tcatggatcc cagtatgaag cccaacatag   1080

acgagacacc aatgtcttgg tgtacatcaa aagaaggcta gcaatgtgtg ccagaagact   1140

cgggaggacc agggaagcag tgaaaatgat gagagattta atgaaggagt tcccccttct   1200

gagtatgttc aatatccatg aaaacctttt agaagccctt ctggaactac aagcatatgc   1260

tgatgttcag gcagtcttag caaagtatga tgatataagc ttaccaaagt cagcaacaat   1320

atgctacaca gctgctttgc tcaaagcaag agctgtctct gacaaattct ctcctgaggc   1380

tgcatctcgg cgggggctga gcacagcaga gatgaatgca gtagaggcca ttcatagagc   1440

tgtggaattc aatcctcatg tgccaaaata cctactagaa atgaaaagct taatcctacc   1500

cccagaacat atcctgaaga gaggagacag tgaagcaata gcatatgcat tctttcatct   1560

tgcacactgg aagagagtgg aaggggcttt gaatcttttg cattgtacgt gggaaggcac   1620

ttttcggatg atcccttatc ccttggaaaa ggggcaccta ttttatcctt acccaatctg   1680

tacagaaaca gcagaccgag agctgcttcc atctttccat gaagtctcag tttacccaaa   1740

gaaggagctt cccttcttta ttctctttac tgctggatta tgttccttca cagccatgct   1800

ggccctcctg acacatcagt tcccggaact tatgggggtc ttcgcaaaag ctatgattga   1860

cattttctgc tcggcagagt tcagggactg gaattgcaag agtattttca tgcgtgttga   1920

agatgaactg gaaatccctc cggcacctca atctcaacat ttccaaaact gaactcatca   1980

cccctcttcc cccaccacca aaactgctcc tcctcctgta ttcctgacct ccgccatcca   2040

ccccgttgct caagccggaa actcggcagc ccttccaaac tcttccctct ctcactcccc   2100

acatcccatc gtctcggcct tcacaatctg tcagttctaa cctcctaagc aactaggcct   2160

tcagtaaatg tgattcacct cttctttccc tccttttccc aaagcatccc tcttagtcta   2220

ggtccttgtt gtttcttgcc tgaactcctg ccatagtctt aactggtctc cttgcttcct   2280

gtcttatcct ccaccgtctt tcttttatac tgacacaaga atggtctttc tgaattgcac   2340

atgtgagcat gtcacttccc tgcttaaatt tctccagtgg attcccaggg acttcaggat   2400

caagtcctag ttgttcagca tggcatccaa gactctttat gatctggccc ttgcttacct   2460

ctcagcctta gctctcccaa ctcttgcaca gtcactgctc ttcagccata gtggatcact   2520

caccattccc agatgtacca ggctctcgca cacctctgca cctttgcacg tgctgtttgc   2580

tgtgcgtgga atgcccttca ctgtcaccac cctgctcatc cactctacta atgcctcttc   2640

attcttttat actcagcttt ctttaaagtt cttctaagct gagttaggtg tctgtccttt   2700

atgatcccgc agtattccat gaatacgtat attctcacat ttattgtact gtattataat   2760

tgttgaaaac ttgtctgtcc catttagaat gtgagctcct tgagagcaga acggtgtctt   2820

cattatctct gtatccccaa ggctttgcac agtgccttgc tcatagtagg ttttcaataa   2880

atgattatta aataaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2970


<210>  1630
<211>  585
<212>  PRT
<213>  Homosapiens

<400>  1630

Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile 
1               5                   10                  15      


Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu 
            20                  25                  30          


Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu 
        35                  40                  45              


Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val 
    50                  55                  60                  


Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe 
65                  70                  75                  80  


Glu Trp Trp Tyr Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val 
                85                  90                  95      


Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser 
            100                 105                 110         


Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln 
        115                 120                 125             


Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg 
    130                 135                 140                 


Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu 
145                 150                 155                 160 


Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe 
                165                 170                 175     


Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys 
            180                 185                 190         


Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu 
        195                 200                 205             


Ala Leu Glu Ile Asn Glu Ile Arg Ser Arg Val Glu Val Pro Leu Ile 
    210                 215                 220                 


Ala Ser Ser Thr Ile Trp Glu Ile Lys Leu Leu Pro Lys Cys Ala Thr 
225                 230                 235                 240 


Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Ala Glu Ala 
                245                 250                 255     


Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly Asp Gly Cys Tyr Arg 
            260                 265                 270         


Arg Ser Gln Gln Leu Gln His His Gly Ser Gln Tyr Glu Ala Gln His 
        275                 280                 285             


Arg Arg Asp Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met 
    290                 295                 300                 


Cys Ala Arg Arg Leu Gly Arg Thr Arg Glu Ala Val Lys Met Met Arg 
305                 310                 315                 320 


Asp Leu Met Lys Glu Phe Pro Leu Leu Ser Met Phe Asn Ile His Glu 
                325                 330                 335     


Asn Leu Leu Glu Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln 
            340                 345                 350         


Ala Val Leu Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr 
        355                 360                 365             


Ile Cys Tyr Thr Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys 
    370                 375                 380                 


Phe Ser Pro Glu Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met 
385                 390                 395                 400 


Asn Ala Val Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val 
                405                 410                 415     


Pro Lys Tyr Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His 
            420                 425                 430         


Ile Leu Lys Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His 
        435                 440                 445             


Leu Ala His Trp Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys 
    450                 455                 460                 


Thr Trp Glu Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly 
465                 470                 475                 480 


His Leu Phe Tyr Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu 
                485                 490                 495     


Leu Leu Pro Ser Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu 
            500                 505                 510         


Pro Phe Phe Ile Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met 
        515                 520                 525             


Leu Ala Leu Leu Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala 
    530                 535                 540                 


Lys Ala Met Ile Asp Ile Phe Cys Ser Ala Glu Phe Arg Asp Trp Asn 
545                 550                 555                 560 


Cys Lys Ser Ile Phe Met Arg Val Glu Asp Glu Leu Glu Ile Pro Pro 
                565                 570                 575     


Ala Pro Gln Ser Gln His Phe Gln Asn 
            580                 585 


<210>  1631
<211>  2604
<212>  DNA
<213>  Homosapiens

<400>  1631
atgccaaggg gatgcacgac atcagagctc agtgactgtg aggactggac ccaagcagct     60

gactccaacg ggcagcaaga agagctggtc cccccagagc ccccagacac acttgcagaa    120

agtgctgcgt tggtaacagc tgccgccacc agagaggaac aagtggggct acgggacgca    180

agctatgcaa gcacaaaggt gcaccagatc cctctgtcat cttccctgac cacccaaggt    240

ggaggaaatg gattccagaa ggaaaactcc tgcatggcag gcagcacgga tgtggtgtgc    300

atcctgacac atgcaatgtc ccgcagaatg agaggtcaag ccgagcgatc agaactccag    360

ctgctgaaaa gagcaaagcc acagaataag gagctgaagc tggcagatgc ccataggaca    420

ggagggggaa aagagtcaca agggatgctg tttgtgaata aaagtgggaa acagaaaaga    480

tactcagaag agctacatgg gggccagagg cagcccttcc ctggtgtcag gagcctgtcg    540

ctcttccctc cctggcccca cctgctttcc agcattggct ggaatgtgaa gcagatagga    600

ggactggaaa gacaggagca ggtggagaaa gaaggcaaat atgaggagga gagagacata    660

gacaaaccac tggacaccgg acagagcatg ctacagccgc aggtctccaa ggctccattt    720

ggaacagagg agaccttggg tcgatcagcc atgagtcagt ccctaccttc agagggcccc    780

tcaactgcat ctcttaacac caagtggccc ctaatgaaga ctcgaggcca cccatccaaa    840

caggatctta gctgtcagtt gtcactcagg aaggaaaaat tccaaactga aggttccctg    900

ggtgtcgccc acacccacgc ctgcaccaag acaaatcgca cggggctagg ctctcccgag    960

aaggcctttg cagaccgctg ctggcctccc agcaagacca tggatcctcc aagcccacta   1020

cagaatccag ctgaagcttt caattatgtc agcctgtgga agtatctaag ggacaaatac   1080

cgatactttg cttgtttgat gagagcccag tctgaagaac atacgaacga aaaggatatg   1140

atgaaggcca tccggctgct gaaggaggct gaggaagaat tctggtacca tcagcatcca   1200

cagccatgca tcttccctga ctctcctagg ggtacctcct atgtgacaca cgagtgctac   1260

aaggtcccag aatggtgctt agatgactgg catccttctg agaaggcaat gtatcctgat   1320

tactttgcca agagaaaaca gtggaagaaa ctgcggaggg aaagctggaa aagagaggtt   1380

aagcagctgc aggaggaaac gccacctgcc ggaaaggaag gtgatttgcc cccactgtgg   1440

tggcatattg tccccgcgac agctgttggg gtgagagcca agtcttctgc agcccccgcc   1500

cctcccccgc aggtgctcct ccttccgtcc tgggatatcc ctcctgagcg catcccgcac   1560

ctgtatttgt taatcaagcc gcggaggaca cagaaatcag cacgtgtttc caggcctggc   1620

ccccacggtg gccctgccgc atcaggccct ctgctcatcg agcgcgcaca cgcggcacaa   1680

gtcattaaga cattctcgac ctgcgaccgg caggcacaca cccactcaca gaggtggcct   1740

catcggagcc cagggccgtg gccgggaagc gccgggaggg tcccagggat gcggtgctac   1800

tgccccctgc tggcagcttc tggaacaccg cgggctgatg acaagacaga atacgcagaa   1860

aggcctcctc ccttcctcca cacagcttta caacagggaa cattcagggg tgcggccctc   1920

agtggggacg tggaactggc tgcggccaga ataactccca gtttgcagag agggaacggg   1980

cagcacagaa aaggagagca gggggaggag ggatcctgta tctgggccct gcacctccag   2040

ggccatactg aagcgtccag ctccttctgc gtaactggtg ccctgcccct gatgctactg   2100

ggcctcccct gcaccatgac cccttctccc tgggtctcct tgcctggatc tcatccctgc   2160

tgcctgcctg ccagtctggt ctcctccccc actgaaggct ctgatcagga gctgaaactt   2220

ctcatatgga accagtgggt ttcctccccg accttcacct acccgtctgc agaggagctg   2280

aaacttccca cagccccagg tctccaggca ctgagcagct ggtgtcccca gacaactctc   2340

tttacaactg gcactgaaag ccagacagcc cagcaccccg gcagtgagga ttccctcccc   2400

tgccatcagt ttgacccacc cttgccacat aggagccaga ccccagaggg catgtctgtc   2460

tgtgtctttc tgcgaactga tctacccagg tgccaagacc tacgccagcc aagcaagaag   2520

ctcctggccc agaagttggt tgacttagcc tctgctccat ccctgctggg gatcccctta   2580

ccttgtacca aaaccattgc ctga                                          2604


<210>  1632
<211>  867
<212>  PRT
<213>  Homosapiens

<400>  1632

Met Pro Arg Gly Cys Thr Thr Ser Glu Leu Ser Asp Cys Glu Asp Trp 
1               5                   10                  15      


Thr Gln Ala Ala Asp Ser Asn Gly Gln Gln Glu Glu Leu Val Pro Pro 
            20                  25                  30          


Glu Pro Pro Asp Thr Leu Ala Glu Ser Ala Ala Leu Val Thr Ala Ala 
        35                  40                  45              


Ala Thr Arg Glu Glu Gln Val Gly Leu Arg Asp Ala Ser Tyr Ala Ser 
    50                  55                  60                  


Thr Lys Val His Gln Ile Pro Leu Ser Ser Ser Leu Thr Thr Gln Gly 
65                  70                  75                  80  


Gly Gly Asn Gly Phe Gln Lys Glu Asn Ser Cys Met Ala Gly Ser Thr 
                85                  90                  95      


Asp Val Val Cys Ile Leu Thr His Ala Met Ser Arg Arg Met Arg Gly 
            100                 105                 110         


Gln Ala Glu Arg Ser Glu Leu Gln Leu Leu Lys Arg Ala Lys Pro Gln 
        115                 120                 125             


Asn Lys Glu Leu Lys Leu Ala Asp Ala His Arg Thr Gly Gly Gly Lys 
    130                 135                 140                 


Glu Ser Gln Gly Met Leu Phe Val Asn Lys Ser Gly Lys Gln Lys Arg 
145                 150                 155                 160 


Tyr Ser Glu Glu Leu His Gly Gly Gln Arg Gln Pro Phe Pro Gly Val 
                165                 170                 175     


Arg Ser Leu Ser Leu Phe Pro Pro Trp Pro His Leu Leu Ser Ser Ile 
            180                 185                 190         


Gly Trp Asn Val Lys Gln Ile Gly Gly Leu Glu Arg Gln Glu Gln Val 
        195                 200                 205             


Glu Lys Glu Gly Lys Tyr Glu Glu Glu Arg Asp Ile Asp Lys Pro Leu 
    210                 215                 220                 


Asp Thr Gly Gln Ser Met Leu Gln Pro Gln Val Ser Lys Ala Pro Phe 
225                 230                 235                 240 


Gly Thr Glu Glu Thr Leu Gly Arg Ser Ala Met Ser Gln Ser Leu Pro 
                245                 250                 255     


Ser Glu Gly Pro Ser Thr Ala Ser Leu Asn Thr Lys Trp Pro Leu Met 
            260                 265                 270         


Lys Thr Arg Gly His Pro Ser Lys Gln Asp Leu Ser Cys Gln Leu Ser 
        275                 280                 285             


Leu Arg Lys Glu Lys Phe Gln Thr Glu Gly Ser Leu Gly Val Ala His 
    290                 295                 300                 


Thr His Ala Cys Thr Lys Thr Asn Arg Thr Gly Leu Gly Ser Pro Glu 
305                 310                 315                 320 


Lys Ala Phe Ala Asp Arg Cys Trp Pro Pro Ser Lys Thr Met Asp Pro 
                325                 330                 335     


Pro Ser Pro Leu Gln Asn Pro Ala Glu Ala Phe Asn Tyr Val Ser Leu 
            340                 345                 350         


Trp Lys Tyr Leu Arg Asp Lys Tyr Arg Tyr Phe Ala Cys Leu Met Arg 
        355                 360                 365             


Ala Gln Ser Glu Glu His Thr Asn Glu Lys Asp Met Met Lys Ala Ile 
    370                 375                 380                 


Arg Leu Leu Lys Glu Ala Glu Glu Glu Phe Trp Tyr His Gln His Pro 
385                 390                 395                 400 


Gln Pro Cys Ile Phe Pro Asp Ser Pro Arg Gly Thr Ser Tyr Val Thr 
                405                 410                 415     


His Glu Cys Tyr Lys Val Pro Glu Trp Cys Leu Asp Asp Trp His Pro 
            420                 425                 430         


Ser Glu Lys Ala Met Tyr Pro Asp Tyr Phe Ala Lys Arg Lys Gln Trp 
        435                 440                 445             


Lys Lys Leu Arg Arg Glu Ser Trp Lys Arg Glu Val Lys Gln Leu Gln 
    450                 455                 460                 


Glu Glu Thr Pro Pro Ala Gly Lys Glu Gly Asp Leu Pro Pro Leu Trp 
465                 470                 475                 480 


Trp His Ile Val Pro Ala Thr Ala Val Gly Val Arg Ala Lys Ser Ser 
                485                 490                 495     


Ala Ala Pro Ala Pro Pro Pro Gln Val Leu Leu Leu Pro Ser Trp Asp 
            500                 505                 510         


Ile Pro Pro Glu Arg Ile Pro His Leu Tyr Leu Leu Ile Lys Pro Arg 
        515                 520                 525             


Arg Thr Gln Lys Ser Ala Arg Val Ser Arg Pro Gly Pro His Gly Gly 
    530                 535                 540                 


Pro Ala Ala Ser Gly Pro Leu Leu Ile Glu Arg Ala His Ala Ala Gln 
545                 550                 555                 560 


Val Ile Lys Thr Phe Ser Thr Cys Asp Arg Gln Ala His Thr His Ser 
                565                 570                 575     


Gln Arg Trp Pro His Arg Ser Pro Gly Pro Trp Pro Gly Ser Ala Gly 
            580                 585                 590         


Arg Val Pro Gly Met Arg Cys Tyr Cys Pro Leu Leu Ala Ala Ser Gly 
        595                 600                 605             


Thr Pro Arg Ala Asp Asp Lys Thr Glu Tyr Ala Glu Arg Pro Pro Pro 
    610                 615                 620                 


Phe Leu His Thr Ala Leu Gln Gln Gly Thr Phe Arg Gly Ala Ala Leu 
625                 630                 635                 640 


Ser Gly Asp Val Glu Leu Ala Ala Ala Arg Ile Thr Pro Ser Leu Gln 
                645                 650                 655     


Arg Gly Asn Gly Gln His Arg Lys Gly Glu Gln Gly Glu Glu Gly Ser 
            660                 665                 670         


Cys Ile Trp Ala Leu His Leu Gln Gly His Thr Glu Ala Ser Ser Ser 
        675                 680                 685             


Phe Cys Val Thr Gly Ala Leu Pro Leu Met Leu Leu Gly Leu Pro Cys 
    690                 695                 700                 


Thr Met Thr Pro Ser Pro Trp Val Ser Leu Pro Gly Ser His Pro Cys 
705                 710                 715                 720 


Cys Leu Pro Ala Ser Leu Val Ser Ser Pro Thr Glu Gly Ser Asp Gln 
                725                 730                 735     


Glu Leu Lys Leu Leu Ile Trp Asn Gln Trp Val Ser Ser Pro Thr Phe 
            740                 745                 750         


Thr Tyr Pro Ser Ala Glu Glu Leu Lys Leu Pro Thr Ala Pro Gly Leu 
        755                 760                 765             


Gln Ala Leu Ser Ser Trp Cys Pro Gln Thr Thr Leu Phe Thr Thr Gly 
    770                 775                 780                 


Thr Glu Ser Gln Thr Ala Gln His Pro Gly Ser Glu Asp Ser Leu Pro 
785                 790                 795                 800 


Cys His Gln Phe Asp Pro Pro Leu Pro His Arg Ser Gln Thr Pro Glu 
                805                 810                 815     


Gly Met Ser Val Cys Val Phe Leu Arg Thr Asp Leu Pro Arg Cys Gln 
            820                 825                 830         


Asp Leu Arg Gln Pro Ser Lys Lys Leu Leu Ala Gln Lys Leu Val Asp 
        835                 840                 845             


Leu Ala Ser Ala Pro Ser Leu Leu Gly Ile Pro Leu Pro Cys Thr Lys 
    850                 855                 860                 


Thr Ile Ala 
865         


<210>  1633
<211>  6559
<212>  DNA
<213>  Homosapiens

<400>  1633
atgggagagc tcaccagagt ccctgtggag tcctgtggtc agtatcagag ctgcggcgag     60

tgccttggct caggcgaccc ccactgtggc tggtgtgtgc tgcacaacac atggctctac    120

tgtaactgca tgcttctctt cctggggggt tcccagcctt tgtctaagtg gcagcaccag    180

cccttgttaa gcacaggctc tcagaaggca ggggctgtgc aagtgttgtt gtctttgtgg    240

tcatcattgt ctgctgctgc tgctggcacc tcgttgctca aggagccaca gtggagccag    300

cgcattgaag cactggggga cactgggaag attactggag tggaaatcag tggactcaag    360

ttcacatgcc ttggaaactt gttaaacatt ttctccagtg accaggcttg gcaggtcccc    420

agccccctct ccatcttccc ctcccatggc ttcgtgccca ggcaaagaag cctgtctcag    480

tctcagcagg gctgcttgca caaggcctac acagtcatga ggaatgggta tgtccttccc    540

agttgcaccc ggaaggagcg gtgtgagcgg tccaaggagc cccgcaggtt tgcctcggag    600

atgaagcagt gtgtccggct gacggtccat cccaacaata tctccgtctc tcagtacaac    660

gtgctgctgg tcctggagac gtacaatgtc ccggagctgt cagctggcgt caactgcacc    720

tttgaggacc tgtcagagat ggatgggctg gtcgtgggca atcagatcca gtgctactcc    780

cctgcagcca aggaggtgcc ccggatcatc acagagaatg gggaccacca tgtcgtacag    840

cttcagctca aatcaaagga gaccggcatg accttcgcca gcaccagctt tgtcttctac    900

aattgcagcg tccacaattc gtgcctgtcc tgcgtggaga gtccataccg ctgccactgg    960

tgtaaatacc ggcatgtctg cacccatgac cccaagacct gctccttcca ggaaggccga   1020

gtgaagctgc ccgaggactg cccccagctg ctgcgagtgg acaagatcct ggtgcccgtg   1080

gaggtgatca agcctatcac gctgaaggcc aagaacctcc cccagcccca gtctgggcag   1140

cgtggctacg aatgcatcct caacattcag ggcagcgagc agcgagtgcc cgccctgcgc   1200

ttcaacagct ccagcgtaca gtgccagaac acctcttatt cctatgaagg gatggagatc   1260

aacaacctgc ccgtggagtt gacagtcgtg tggaatgggc acttcaacat tgacaaccca   1320

gctcagaata aagttcacct ctacaagtgt ggagccatgc gtgagagctg cgggctgtgc   1380

ctcaaggctg acccagactt cgcatgtggc tggtgccagg gcccaggcca gtgcaccctg   1440

cgccagcact gccctgccca ggagagccag tggctggagc tgtctggtgc caaaagcaag   1500

tgcacaaacc cccgcatcac agagataatc ccggtgacag gcccccggga agggggcacc   1560

aaggtcacta tccgagggga gaacctgggc ctggaatttc gcgacatcgc ctcccatgtc   1620

aaggttgctg gcgtggagtg cagcccttta gtggatggtt acatccctgc agaacagatc   1680

gtgtgtgaga tgggggaggc caagcccagc cagcatgcag gcttcgtgga gatctgcgtg   1740

gctgtgtgtc ggcctgaatt catggcccgg tcctcacagc tctattactt catgacactg   1800

actctctcag atctgaagcc cagccggggg cccatgtccg gagggaccca agtgaccatc   1860

acaggcacca acctgaatgc cggaagcaac gtggtggtga tgtttggaaa gcagccctgt   1920

ctcttccaca ggcgatctcc atcctacatt gtctgcaaca ccacatcctc agatgaggtg   1980

ctagagatga aggtgtcggt gcaggtggac agggccaaga tccaccagga cctggtcttt   2040

cagtatgtgg aagaccccac catcgtgcgg attgagccag aatggagcat tgtcagtgga   2100

aacacaccca tcgccgtatg ggggacccac ctggacctca tacagaaccc ccagatccgt   2160

gccaagcatg gagggaagga gcacatcaat atctgtgagg ttctgaacgc tactgagatg   2220

acctgtcagg cgcccgccct cgctctgggt cctgaccacc agtcagacct gaccgagagg   2280

cccgaggagt ttggcttcat cctggacaac gtccagtccc tgctcatcct caacaagacc   2340

aacttcacct actatcccaa cccggtgttt gaggcctttg gtccctcagg aatcctggag   2400

ctcaagcctg gcacgcccat catcctaaag ggcaagaacc tgatcccgcc tgtggctggg   2460

ggcaacgtga agctgaacta cactgtgctg gttggggaga agccgtgcac cgtgaccgtg   2520

tcagatgtcc agctgctctg cgagtccccc aacctcatcg gcaggcacaa agtgatggcc   2580

cgtgtcggtg gcatggagta ctccccgggg atggtgtaca ttgccccgga cagcccgctc   2640

agcctgcccg ccatcgtcag catcgcagtg gctggcggcc tcctcatcat tttcatcgtg   2700

gccgtgctca ttgcctataa acgcaagtcc cgcgaaagtg acctcacgct gaagcggctg   2760

cagatgcaga tggacaacct ggagtcccgt gtggccctgg agtgcaagga aggtactgag   2820

tggccccatg ctggaggcca tgtgtgtgtg cgtgtgtgca tatgtgtgtg catgcacatc   2880

tgtgtatgtg tatgcatatg tttcatatac aaacaagcag gctgggcagc agtgggcagt   2940

gctggaggct ggcggtgtgt gtgtctgtgc gaatgtgtgt gtgtgcatgt gtgtgtgtgc   3000

acatctgtat gtatatatgt ttcatataca agcaagcagg ccgggcagca gtgagcagtg   3060

ctggaggctg tatatgtgtc tgtgtgcgtg cgcatctgtg tatgtgtata tgtttcatgt   3120

acaagcaagc aggccgggca gcagtgggca gtgctggagg ctctgtgtgt gcgtgtgcat   3180

gtgtgtgtat gtatgtgtat gtgttccatt tacaagcaag caggccaggc aactgtgagc   3240

agtgctggag gctgtgtgcg cgtgtgtgtg tgtatgtgta tgtgtttcat ttacaagcaa   3300

gcaggccagg cagctgtgag cagtgctgga ggctgtgtgt gtgtgtgtgt gagcacgcac   3360

gtgtgtgagc acgcacgtgt atgtgtatgt gtgtcattta caagcaagca ggccaggcag   3420

ctgtgagcag tgctggaggc cgtgtgtgtg tgtgtgtgtg tgtgtgcgcg cgcgcctgta   3480

tatgtgtatg tgtttcattt acaagcaagc aggccaggca gctgtgggca gtgctggagg   3540

ctgtgtgtgt gtgcacgtgt gtgtatgcgt atgtgtttca tttacaagca agcaggccag   3600

gcagctgtgg gcagtgctgg aggctgtgtg tgtgtgtgtg tgtgtgtgtg tgtatatatg   3660

tgtatgtgta tgtgtttcat ttacaagcaa gcagcccagg cagctgtggg cagtgctgga   3720

ggctgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgtttca tttacaagtg tgtgtgtgtg   3780

tgtgtatgtg tatgtgtatg tgtttcattt acaagcaagc aggccaggca gctgtgggca   3840

atgctggagg ctgtgcatcc tacctgcata cctgcaaagc ctctcactct atagtcccta   3900

tgcctgtgtc ccagaccaca cccataccca agcaggcccc accctggcaa caccagagag   3960

gccaaggtct ccttgccctc tccttgaagg tgtagtgatt agaatctctt ttatgtgtgg   4020

caggcacaca gctttgaatg ttggaggcgc ttggtgactt aaaggaaagc tgcagactga   4080

taaaaagcca actccctcct tctgctccct gtgggccgag caccccaact gggagggggc   4140

agccgagggg agctcccacc caggattgtc accttcaccc cactagagca ccttcacccc   4200

actagagcag cctccatacc tggaatcctg gttgagtggg ttttgcactc tactcgaggg   4260

gaggtctggg ggtgtcttaa catgacgcat ttcagcaatc tccagctttc ttcctctagc   4320

aggaaggtaa ggctgtaggg ctgatctgtg atttagaagg aagggtgttt caaagcttgt   4380

attaaaaaaa ttacaaacac caccataaag tgaaatcagc tgcactaaat ccaagaagga   4440

aatttaggag tcagactctt gtaaccccca ggatatcatt ttgtgactca tcctgggagg   4500

atctgagctg gttctttgct gtagatttgt acatggagta aatccggccc catacctggg   4560

gctctcactt cacaccgatt cccaccaggg cagccacggc tctttttgat ggggaagtgg   4620

atccattcca tcccctctct acatccttca gctgtcaaca cagcatccgc cttgtgggac   4680

tgttaattac tgccttttat tatatttacg ctgcttaatt tttttctccg caatgtactc   4740

tttcctctaa ttaggtgtag tgattagaat ctcttttatg tgtggcaggc acgcagcttt   4800

gaatgttgga ggcgcttggt gacttaaagg aaagctgcag actgataaaa agccaacacc   4860

ctccttctgc tccctgtggg ccgagcaccc caactgggag ggagcagccg atgggagctc   4920

ccacccagga ttgtcagctg aggccccagg aggaaacctt ggcttcagac tttaggggcg   4980

agctatgctg tgcacgtagg aagaaggggt cttacagcaa aggacttgtc agactagcca   5040

cagaggcact ttgcagcttg cccagagcca gccactgaac gtttacaggg ctgcactggc   5100

ccaagccaag gggtctcctt gaagacttca cagcaagcca ggacgtcctc tacacaaact   5160

cagaagacac ccagctgggc ccttcatggg cctaagcttc tgatatataa acatacccgt   5220

gtatttacaa acactcccac acaggcccac acaccctcac tgacatacac tcatggactc   5280

acacatacac tcacatgcac acatgcatgc acactcacat acactcactc gtgcactcac   5340

acatacatgc ccacacatag tgacatgctc acacactcat gctttcacat acatacactc   5400

actgacatac actcatgtgc tcacacgctc atgtactcac attcgtacac acacactgac   5460

atatacttac acactcacac ttgcacatgc atacacatgc actcacatgc acacatgcat   5520

gcacactcat acactcacgc actcaacttg caggcgtgca cacacatgcc cacatactca   5580

tgcactcaca ttcacacatg cgtgcacaca tagacgcatg cactcacaca tgcatacaca   5640

cagacataca catgcactca cattcgtact tgcatacaca ccaacacaca tatgcacact   5700

cacactgaca agcatacaca cacactcatg cactcacacc cacgcaggca ctcacattca   5760

cacacataca cactcattga catacattca ttcacatcca tgcactcaca ttcacacatg   5820

catacacact gacattcaca cttgcacatg cctacacact cactgacata cacacacaca   5880

tgcagtcata cacactccct gacatgctca cacactgtca tactcacaca ctccctgaca   5940

tgctcacaca ctgtcacact cacacactca catacactcc ctgacataca cactcagaca   6000

agtgcccatg cacccacacc tatgctcatg cacatgttcc cacactctct tataagcata   6060

cacacccatg ttcctcactc aggacacaca tgaatgttcc acagggcatc atgtgacatc   6120

gcagaggaca gatggtggaa aagacatgag caacctaatg ggaagaggaa aatgggaaac   6180

aatgcattgg aagaggaaga aaaaaaataa ataaccaaag gttttggcaa gtgcagtacc   6240

aggtggagaa gcttgacttt tctatccttg atcattttat tccctcccaa gaagtcagtc   6300

acaggacctg gaaggccaga aagggtacat gtgggagacg gtctgaggaa gtacctcggt   6360

cactacaata tttttgcaca tataaagggt tggggaggaa agagacacaa acgtatttaa   6420

cacagatttg ctggatggaa gctgcgtgtg tgaacgtgtg tatgagtgag tgcattttga   6480

tttttttttt ttttttttgc acagttaaga gaaaaaatca aacaagcaga aaaaaaaaag   6540

aaaaaagact tatcacggt                                                6559


<210>  1634
<211>  1017
<212>  PRT
<213>  Homosapiens

<400>  1634

Met Gly Glu Leu Thr Arg Val Pro Val Glu Ser Cys Gly Gln Tyr Gln 
1               5                   10                  15      


Ser Cys Gly Glu Cys Leu Gly Ser Gly Asp Pro His Cys Gly Trp Cys 
            20                  25                  30          


Val Leu His Asn Thr Trp Leu Tyr Cys Asn Cys Met Leu Leu Phe Leu 
        35                  40                  45              


Gly Gly Ser Gln Pro Leu Ser Lys Trp Gln His Gln Pro Leu Leu Ser 
    50                  55                  60                  


Thr Gly Ser Gln Lys Ala Gly Ala Val Gln Val Leu Leu Ser Leu Trp 
65                  70                  75                  80  


Ser Ser Leu Ser Ala Ala Ala Ala Gly Thr Ser Leu Leu Lys Glu Pro 
                85                  90                  95      


Gln Trp Ser Gln Arg Ile Glu Ala Leu Gly Asp Thr Gly Lys Ile Thr 
            100                 105                 110         


Gly Val Glu Ile Ser Gly Leu Lys Phe Thr Cys Leu Gly Asn Leu Leu 
        115                 120                 125             


Asn Ile Phe Ser Ser Asp Gln Ala Trp Gln Val Pro Ser Pro Leu Ser 
    130                 135                 140                 


Ile Phe Pro Ser His Gly Phe Val Pro Arg Gln Arg Ser Leu Ser Gln 
145                 150                 155                 160 


Ser Gln Gln Gly Cys Leu His Lys Ala Tyr Thr Val Met Arg Asn Gly 
                165                 170                 175     


Tyr Val Leu Pro Ser Cys Thr Arg Lys Glu Arg Cys Glu Arg Ser Lys 
            180                 185                 190         


Glu Pro Arg Arg Phe Ala Ser Glu Met Lys Gln Cys Val Arg Leu Thr 
        195                 200                 205             


Val His Pro Asn Asn Ile Ser Val Ser Gln Tyr Asn Val Leu Leu Val 
    210                 215                 220                 


Leu Glu Thr Tyr Asn Val Pro Glu Leu Ser Ala Gly Val Asn Cys Thr 
225                 230                 235                 240 


Phe Glu Asp Leu Ser Glu Met Asp Gly Leu Val Val Gly Asn Gln Ile 
                245                 250                 255     


Gln Cys Tyr Ser Pro Ala Ala Lys Glu Val Pro Arg Ile Ile Thr Glu 
            260                 265                 270         


Asn Gly Asp His His Val Val Gln Leu Gln Leu Lys Ser Lys Glu Thr 
        275                 280                 285             


Gly Met Thr Phe Ala Ser Thr Ser Phe Val Phe Tyr Asn Cys Ser Val 
    290                 295                 300                 


His Asn Ser Cys Leu Ser Cys Val Glu Ser Pro Tyr Arg Cys His Trp 
305                 310                 315                 320 


Cys Lys Tyr Arg His Val Cys Thr His Asp Pro Lys Thr Cys Ser Phe 
                325                 330                 335     


Gln Glu Gly Arg Val Lys Leu Pro Glu Asp Cys Pro Gln Leu Leu Arg 
            340                 345                 350         


Val Asp Lys Ile Leu Val Pro Val Glu Val Ile Lys Pro Ile Thr Leu 
        355                 360                 365             


Lys Ala Lys Asn Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly Tyr Glu 
    370                 375                 380                 


Cys Ile Leu Asn Ile Gln Gly Ser Glu Gln Arg Val Pro Ala Leu Arg 
385                 390                 395                 400 


Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Thr Ser Tyr Ser Tyr Glu 
                405                 410                 415     


Gly Met Glu Ile Asn Asn Leu Pro Val Glu Leu Thr Val Val Trp Asn 
            420                 425                 430         


Gly His Phe Asn Ile Asp Asn Pro Ala Gln Asn Lys Val His Leu Tyr 
        435                 440                 445             


Lys Cys Gly Ala Met Arg Glu Ser Cys Gly Leu Cys Leu Lys Ala Asp 
    450                 455                 460                 


Pro Asp Phe Ala Cys Gly Trp Cys Gln Gly Pro Gly Gln Cys Thr Leu 
465                 470                 475                 480 


Arg Gln His Cys Pro Ala Gln Glu Ser Gln Trp Leu Glu Leu Ser Gly 
                485                 490                 495     


Ala Lys Ser Lys Cys Thr Asn Pro Arg Ile Thr Glu Ile Ile Pro Val 
            500                 505                 510         


Thr Gly Pro Arg Glu Gly Gly Thr Lys Val Thr Ile Arg Gly Glu Asn 
        515                 520                 525             


Leu Gly Leu Glu Phe Arg Asp Ile Ala Ser His Val Lys Val Ala Gly 
    530                 535                 540                 


Val Glu Cys Ser Pro Leu Val Asp Gly Tyr Ile Pro Ala Glu Gln Ile 
545                 550                 555                 560 


Val Cys Glu Met Gly Glu Ala Lys Pro Ser Gln His Ala Gly Phe Val 
                565                 570                 575     


Glu Ile Cys Val Ala Val Cys Arg Pro Glu Phe Met Ala Arg Ser Ser 
            580                 585                 590         


Gln Leu Tyr Tyr Phe Met Thr Leu Thr Leu Ser Asp Leu Lys Pro Ser 
        595                 600                 605             


Arg Gly Pro Met Ser Gly Gly Thr Gln Val Thr Ile Thr Gly Thr Asn 
    610                 615                 620                 


Leu Asn Ala Gly Ser Asn Val Val Val Met Phe Gly Lys Gln Pro Cys 
625                 630                 635                 640 


Leu Phe His Arg Arg Ser Pro Ser Tyr Ile Val Cys Asn Thr Thr Ser 
                645                 650                 655     


Ser Asp Glu Val Leu Glu Met Lys Val Ser Val Gln Val Asp Arg Ala 
            660                 665                 670         


Lys Ile His Gln Asp Leu Val Phe Gln Tyr Val Glu Asp Pro Thr Ile 
        675                 680                 685             


Val Arg Ile Glu Pro Glu Trp Ser Ile Val Ser Gly Asn Thr Pro Ile 
    690                 695                 700                 


Ala Val Trp Gly Thr His Leu Asp Leu Ile Gln Asn Pro Gln Ile Arg 
705                 710                 715                 720 


Ala Lys His Gly Gly Lys Glu His Ile Asn Ile Cys Glu Val Leu Asn 
                725                 730                 735     


Ala Thr Glu Met Thr Cys Gln Ala Pro Ala Leu Ala Leu Gly Pro Asp 
            740                 745                 750         


His Gln Ser Asp Leu Thr Glu Arg Pro Glu Glu Phe Gly Phe Ile Leu 
        755                 760                 765             


Asp Asn Val Gln Ser Leu Leu Ile Leu Asn Lys Thr Asn Phe Thr Tyr 
    770                 775                 780                 


Tyr Pro Asn Pro Val Phe Glu Ala Phe Gly Pro Ser Gly Ile Leu Glu 
785                 790                 795                 800 


Leu Lys Pro Gly Thr Pro Ile Ile Leu Lys Gly Lys Asn Leu Ile Pro 
                805                 810                 815     


Pro Val Ala Gly Gly Asn Val Lys Leu Asn Tyr Thr Val Leu Val Gly 
            820                 825                 830         


Glu Lys Pro Cys Thr Val Thr Val Ser Asp Val Gln Leu Leu Cys Glu 
        835                 840                 845             


Ser Pro Asn Leu Ile Gly Arg His Lys Val Met Ala Arg Val Gly Gly 
    850                 855                 860                 


Met Glu Tyr Ser Pro Gly Met Val Tyr Ile Ala Pro Asp Ser Pro Leu 
865                 870                 875                 880 


Ser Leu Pro Ala Ile Val Ser Ile Ala Val Ala Gly Gly Leu Leu Ile 
                885                 890                 895     


Ile Phe Ile Val Ala Val Leu Ile Ala Tyr Lys Arg Lys Ser Arg Glu 
            900                 905                 910         


Ser Asp Leu Thr Leu Lys Arg Leu Gln Met Gln Met Asp Asn Leu Glu 
        915                 920                 925             


Ser Arg Val Ala Leu Glu Cys Lys Glu Gly Thr Glu Trp Pro His Ala 
    930                 935                 940                 


Gly Gly His Val Cys Val Arg Val Cys Ile Cys Val Cys Met His Ile 
945                 950                 955                 960 


Cys Val Cys Val Cys Ile Cys Phe Ile Tyr Lys Gln Ala Gly Trp Ala 
                965                 970                 975     


Ala Val Gly Ser Ala Gly Gly Trp Arg Cys Val Cys Leu Cys Glu Cys 
            980                 985                 990         


Val Cys Val His Val Cys Val Cys  Thr Ser Val Cys Ile  Tyr Val Ser 
        995                 1000                 1005             


Tyr Thr  Ser Lys Gln Ala Gly  Gln Gln 
    1010                 1015         


<210>  1635
<211>  2822
<212>  DNA
<213>  Homosapiens

<400>  1635
ggcgcggtac aggagcagca ctgccggcgg gggcgggtgc cagggacttg gaggtggagg     60

ggacgcggcg gtactctggc gtcttccgac ttcgactcct taccttaaaa gatgctggag    120

tcatatgtaa ctccaatttt aatgagctat gtgaatcgct acatcaagaa cttaaagccg    180

tcggatctac agctttcact atggggtgga gacgtggtac tcagcaagct cgagttaaag    240

ttggatgtgc tggaacagga actgaaatta ccattcactt ttttaagtgg acatattcat    300

gaattgagga ttcatgtacc atggacaaaa ctgggttcag aaccagtggt aattaccatc    360

aatactatgg aatgcatttt gaaacttaag gatgggatac aggatgacca tgaaagctgt    420

ggttctaatt ctaccaaccg tagtactgct gagagcacaa aatcatcaat caaaccgcgg    480

agaatgcagc aggctgctcc tacagatcct gacttaccac caggttatgt gcagagtctg    540

attagacgag ttgtaaataa tgtaaacatt gtgataaata atctcatact aaaatatgtt    600

gaagatgata tcgtcctttc cgtcaatatc acttctgcag aatgttatac agtaggtgaa    660

ttatgggatc gtgcattcat ggatatttct gcaactgatt tggtgctgag aaaggttatc    720

aatttttctg actgtacagt ttgtcttgat aaacggaatg ccagtggtaa aatagaattt    780

taccaggatc ctttattata caaatgttcc ttcagaactc gtcttcattt tacatatgaa    840

aacctaaatt ccaagatgcc atctgttatt aaaattcata ctttagtgga aagtttgaaa    900

ctttctatca cagatcaaca actgcctatg tttattcgta taatgcaact tggaattgct    960

ctttactatg gagaaatagg caattttaaa gaaggcgaaa tagaggacct tacttgtcat   1020

aataaagata tgctaggaaa cattacaggt tctgaagatg aaacaagaat agatatgcaa   1080

tatcctgctc agcataaagg tcaagagtta tattcacagc aagatgagga gcagccacag   1140

ggatgggtgt catgggcctg gtcctttgtg cctgcaattg tgagttatga cgatggcgag   1200

gaagactttg ttgggaacga tcctgcatca accatgcatc aacaaaaagc acagactttg   1260

aaggatccta ttgtttctat aggattttat tgcacaaagg caacggtgac tttcaaactc   1320

acagaaatgc aagttgagag tagttattac agtccacaga aagtaaaatc taaagaagta   1380

ttgtgttggg aacaagaagg aactacagtt gaggccctta tgatgggaga acctttcttt   1440

gattgccaga ttgggtttgt tggttgcaga gccatgtgcc ttaaaggaat tatgggtgtt   1500

aaagattttg aagagaatat gaatagaagt gaaactgaag cctgtttctt catttgtggt   1560

gacaatttga gtacgaaagg tttcacatac cttacaaatt cattgtttga ttaccgaagc   1620

ccagaaaata atggtactcg cgcagaattt atcttggatt caactcatca taaggagaca   1680

tacactgaga tagctggaat gcaacggttt ggggcttttt atatggatta cctgtataca   1740

atggagaaca ctagtggcaa aggttccaca aatcaacaag acttttcttc agggaaaagt   1800

gaagatttgg gaacagttca ggagaagtcc accaaaagcc ttgttatagg tcctcttgat   1860

tttcgtttgg atagcagtgc ggtgcatagg attttgaaaa tgattgtgtg tgccttggaa   1920

catgaatatg aaccatatag caggctaaaa tcagatatta aggatgaaaa tgaaacaata   1980

ctgaatcctg aagaggtggc tcttctggag gaatatattc ctactcgaca tacaagtgtt   2040

actctcctca aatgtacctg cacaatttcc atggctgaat tcaacttgct ggaccattta   2100

ctacctgtca ttatgggaga aaagaactca agtaacttca tgaatactac aaacttccag   2160

tctcttcggc ctttgccatc cattcgaata ttggtggata aaattaatct ggaacattca   2220

gtgccaatgt atgctgaaca gttggtgcat gtggtcagca gccttactca accttctgat   2280

aacctgcttc attattgtta tgtacactgc tatcttaaga tatttggttt ccaggcagga   2340

ctgacgtctt tggattgcag tggatcttac tgcttacctg taccagttat tccctctttc   2400

agcactgctc tttatgggaa acttctgaaa ctccccacat gctggaccaa aagatctcag   2460

attgctataa ctgaaggtat atttgaactt ccaaatctca caattcaagc tacaagagca   2520

cagacacttc tcttgcaagc aatatatcaa agttggtctc atcttggaaa tgtcagctct   2580

tccgcagtga ttgaagcttt gataaatgaa atcttcctaa gtatagagat tgggtcttgc   2640

tatgttgccc aggttgatct tgaactcctg gcctcaaatg atcctcccac ctcaacctcc   2700

tgaagtgccg ggattggagg cccaagccac tgtgcctggc cctttataaa ttatgttata   2760

atttcatgta atacataatt gtatagtcaa aatggctcac atattaaata ttctttatac   2820

aa                                                                  2822


<210>  1636
<211>  863
<212>  PRT
<213>  Homosapiens

<400>  1636

Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg 
1               5                   10                  15      


Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly 
            20                  25                  30          


Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu 
        35                  40                  45              


Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu 
    50                  55                  60                  


Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val 
65                  70                  75                  80  


Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile 
                85                  90                  95      


Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr 
            100                 105                 110         


Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala 
        115                 120                 125             


Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile 
    130                 135                 140                 


Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu 
145                 150                 155                 160 


Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala 
                165                 170                 175     


Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile 
            180                 185                 190         


Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys 
        195                 200                 205             


Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr 
    210                 215                 220                 


Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe 
225                 230                 235                 240 


Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His 
                245                 250                 255     


Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro 
            260                 265                 270         


Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu 
        275                 280                 285             


Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn 
    290                 295                 300                 


Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln 
                325                 330                 335     


Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe 
            340                 345                 350         


Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly 
        355                 360                 365             


Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys 
    370                 375                 380                 


Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr 
385                 390                 395                 400 


Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln 
                405                 410                 415     


Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr 
            420                 425                 430         


Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly 
        435                 440                 445             


Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys 
    450                 455                 460                 


Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe 
465                 470                 475                 480 


Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn 
                485                 490                 495     


Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu 
            500                 505                 510         


Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala 
        515                 520                 525             


Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Met 
    530                 535                 540                 


Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser 
545                 550                 555                 560 


Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser 
                565                 570                 575     


Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His 
            580                 585                 590         


Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro 
        595                 600                 605             


Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asp Glu Asn Glu Thr Ile Leu 
    610                 615                 620                 


Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His 
625                 630                 635                 640 


Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu 
                645                 650                 655     


Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn 
            660                 665                 670         


Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu 
        675                 680                 685             


Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val 
    690                 695                 700                 


Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln 
705                 710                 715                 720 


Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys 
                725                 730                 735     


Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser 
            740                 745                 750         


Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr 
        755                 760                 765             


Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile 
    770                 775                 780                 


Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala 
785                 790                 795                 800 


Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser 
                805                 810                 815     


His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn 
            820                 825                 830         


Glu Ile Phe Leu Ser Ile Glu Ile Gly Ser Cys Tyr Val Ala Gln Val 
        835                 840                 845             


Asp Leu Glu Leu Leu Ala Ser Asn Asp Pro Pro Thr Ser Thr Ser 
    850                 855                 860             


<210>  1637
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1637
ggcgcggtac aggagcagca ctgccggcgg gggcgggtgc cagggacttg gaggtggagg     60

ggacgcggcg gtactctggc gtcttccgac ttcgactcct taccttaaaa gatgctggag    120

tcatatgtaa ctccaatttt aatgagctat gtgaatcgct acatcaagaa cttaaagccg    180

tcggatctac agctttcact atggggtgga gacgtggtac tcagcaagct cgagttaaag    240

ttggatgtgc tggaacagga actgaaatta ccattcactt ttttaagtgg acatattcat    300

gaattgagga ttcatgtacc atggacaaaa ctgggttcag aaccagtggt aattaccatc    360

aatactatgg aatgcatttt gaaacttaag gatgggatac aggatgacca tgaaagctgt    420

ggttctaatt ctaccaaccg tagtactgct gagagcacaa aatcatcaat caaaccgcgg    480

agaatgcagc aggctgctcc tacagatcct gacttaccac caggttatgt gcagagtctg    540

attagacgag ttgtaaataa tgtaaacatt gtgataaata atctcatact aaaatatgtt    600

gaagatgata tcgtcctttc cgtcaatatc acttctgcag aatgttatac agtaggtgaa    660

ttatgggatc gtgcattcat ggatatttct gcaactgatt tggtgctgag aaaggttatc    720

aatttttctg actgtacagt ttgtcttgat aaacggaatg ccagtggtaa aatagaattt    780

taccaggatc ctttattata caaatgttcc ttcagaactc gtcttcattt tacatatgaa    840

aacctaaatt ccaagatgcc atctgttatt aaaattcata ctttagtgga aagtttgaaa    900

ctttctatca cagatcaaca actgcctatg tttattcgta taatgcaact tggaattgct    960

ctttactatg gagaaatagg caattttaaa gaaggcgaaa tagaggacct tacttgtcat   1020

aataaagata tgctaggaaa cattacaggt tctgaagatg aaacaagaat agatatgcaa   1080

tatcctgctc agcataaagg tcaagagtta tattcacagc aagatgagga gcagccacag   1140

ggatgggtgt catgggcctg gtcctttgtg cctgcaattg tgagttatga cgatggcgag   1200

gaagactttg ttgggaacga tcctgcatca accatgcatc aacaaaaagc acagactttg   1260

aaggatccta ttgtttctat aggattttat tgcacaaagg caacggtgac tttcaaactc   1320

acagaaatgc aagttgagag tagttattac agtccacaga aagtaaaatc taaagaagta   1380

ttgtgttggg aacaagaagg aactacagtt gaggccctta tgatgggaga acctttcttt   1440

gattgccaga ttgggtttgt tggttgcaga gccatgtgcc ttaaaggaat tatgggtgtt   1500

aaagattttg aagagaatat gaatagaagt gaaactgaag cctgtttctt catttgtggt   1560

gacaatttga gtacgaaagg tttcacatac cttacaaatt cattgtttga ttaccgaagc   1620

ccagaaaata atggtactcg cgcagaattt atcttggatt caactcatca taaggagaca   1680

tacactgaga tagctggaat gcaacggttt ggggcttttt atatggatta cctgtataca   1740

atggagaaca ctagtggcaa aggttccaca aatcaacaag acttttcttc agggaaaagt   1800

gaagatttgg gaacagttca ggagaagtcc accaaaagcc ttgttatagg tcctcttgat   1860

tttcgtttgg atagcagtgc ggtgcatagg attttgaaaa tgattgtgtg tgccttggaa   1920

catgaatatg aaccatatag caggctaaaa tcagatatta aggatgaaaa tgaaacaata   1980

ctgaatcctg aagaggtggc tcttctggag gaatatattc ctactcgaca tacaagtgtt   2040

actctcctca aatgtacctg cacaatttcc atggctgaat tcaacttgct ggaccattta   2100

ctacctgtca ttatgggaga aaagaactca agtaacttca tgaatactac aaacttccag   2160

tctcttcggc ctttgccatc cattcgaata ttggtggata aaattaatct ggaacattca   2220

gtgccaatgt atgctgaaca gttggtgcat gtggtcagca gccttactca accttctgat   2280

aacctgcttc attattgtta tgtacactgc tatcttaaga tatttggttt ccaggcagga   2340

ctgacgtctt tggattgcag tggatcttac tgcttacctg taccagttat tccctctttc   2400

agcactgctc tttatgggaa acttctgaaa ctccccacat gctggaccaa aagatctcag   2460

attgctataa ctgaaggtat atttgaactt ccaaatctca caattcaagc tacaagagca   2520

cagacacttc tcttgcaagc aatatatcaa agttggtctc atcttggaaa tgtcagctct   2580

tccgcagtga ttgaagcttt gataaatgaa atcttcctaa gtataggtgt gaaatctaag   2640

aatcccctgc caactcttga gggctcaatc cagaatgttg aattgaagta ctgcagcaca   2700

tcattggtca aatgtgcctc tgggaccatg ggatcaataa aaatttgtgc caaagcccca   2760

gttgatagtg gaaaagagaa gttgattccc ttgcttcagg gtccttctga cactaaagac   2820

cttcatagca ccaagtggct caatgagagt agaaagccag agtctctctt agctccagat   2880

ttgatggcct tcacaatcca agttccacaa tatattgact actgccacaa ttccggtgct   2940

gtacttcttt gcagtataca aggactagca gttaatattg acccaatctt atatacgtgg   3000

ctcatctatc agcctcagaa acgaacaagt agacatatgc aacagcagcc tgtggtagct   3060

gttcctcttg ttatgccagt ttgtagaagg aaagaggatg aggtgtctat tggaagtgcc   3120

cccttggcaa agcagcaatc atatcaggcc tctgaatatg ccagcagccc tgtaaaaaca   3180

aaaacggtaa cagaatcccg cccattgtca gttcctgtta aagccatgtt gaatatatct   3240

gaaagctgta gaagtcctga agaaagaatg aaggaattta ttggaattgt ttggaatgca   3300

gtgaagcatc tcacactaca gcttgaagta caatcttgtt gtgtgtttat tccaaatgat   3360

agcctgcctt ccccaagtac aattgtatct ggtgacattc ctggaacagt aagaagttgg   3420

taccatggac aaaccagcat gccgggaaca cttgtcctct gtttgcctca aataaagatt   3480

attagtgctg ggcacaagta tatggaacct ctgcaggaga ttccatttgt tatcccacga   3540

cccatccttg aagaaggtga tgcttttcct tggacgatca gcttgcataa tttcagcata   3600

tatacccttc ttggaaaaca agtgacactt tgcctagtgg aacctatggg ttgcacctcc   3660

actctagctg tcacgtctca aaaactgctt gctacgggac ctgatacacg acattcattt   3720

gttgtctgtc tccatgttga cctagagtca ctagagataa aatgctctaa tccccaggtc   3780

cagctcttct atgaactaac tgatatcatg aataaggtct ggaacaagat tcagaagaga   3840

ggcaatctca acctatctcc aacctctcca gagaccatgg cagggcctgt tcctacttct   3900

ccagttagaa gcagtatagg cacagctcct ccagatacca gcacatgcag cccatctgct   3960

gacattggga ctactactga gggagattct atacaagcag gtgaggaatc accattctca   4020

gattctgtga ccttggaaca aactacaagt aatattggag gaaccagtgg acgtgttagt   4080

ttatggatgc agtgggtgct tcccaaaatt actataaagc tctttgctcc agatcctgaa   4140

aataaaggca cagaggtttg tatggtcagt gaactagaag atctcagtgc ttccatagat   4200

gtccaggatg tatataccaa agtgaaatgt aaaatagaga gtttcaatat tgatcactat   4260

agaagcaggc caggggaagg ttggcagtca ggacattttg aaggagtatt tctacaatgc   4320

aaagaaaaat ctgtgacaac tacaaaactt ctagatggca ctcatcagca gcatggattc   4380

ctctctctga catacacaaa agctgtaaca aaaaatgtcc gccacaagtt aacatcaaga   4440

aatgagcgaa gaagttttca taagttatct gaaggcctaa tggatggttc tcctcatttt   4500

cttcatgaaa ttcttctttc agcacaagct tttgatattg ttctttattt tcctttactt   4560

aatgccattg caagtatatt tcaagcaaaa ctaccaaaga cccaaaaaga gaaaagaaaa   4620

tctcctggtc agcccatgag gacccataca ctgacatccc gcaatttacc tttgatttat   4680

gtcaacacaa gtgtaatcag aatttttatt ccaaaaacag aagaaatgca gccaactgtt   4740

gaagctaatc aggcagcaaa agaagacact gtggttttga agattggctc tgttgccatg   4800

gctccccagg ctgacaatcc ccttggcaga tctgtcctta ggaaagatat ttaccagaga   4860

gccttgaact taggaattct tcgagatcct ggatcagaaa tcgaagacag acaataccaa   4920

atagatctgc agtccatcaa tattggtact gcacagtggc atcaactaaa accagagaag   4980

gaaagtgtct caggaggggt ggtaacagag actgaaagga attctcaaaa tccagccctt   5040

gagtggaata tggccagcag catacggcgg catcaagaaa ggagagcaat tttgaccccc   5100

gttttgacag atttttctgt ccgaataact ggagcacctg ctgtcatttt caccaaagta   5160

gtttctccag aaaatttgca tactgaggag attttagtgt gtggccattc cttagaagtg   5220

aatataacca caaacctgga cttcttccta agtgtggctc aagttcaact cttacatcag   5280

ttaatagtag caaatatgac tggactggaa ccatcaaaca aggctgcaga gatctctaaa   5340

caagaacaga aaaaagtgga tatatttgat ggaggcatgg ctgaaacctc atctcgctac   5400

agtggtgctc aggatagtgg aattggcagt gacagtgtta aaatcagaat agtgcaaata   5460

gagcagcaca gtggtgccag tcagcatcgc attgcccgtc cctcacgcca gtcatcaatt   5520

gtaaaaaatc taaattttat tccctttgac atatttatta ctgcaagtag aatctcacta   5580

atgacctatt cctgtatggc cttatccaaa tcgaaatcac aagaacagaa gaataatgaa   5640

aaaacagaca agagttcatt aaatctccca gaagttgatt cagatgttgc taagcccaac   5700

caggcatgta tttccacggt gacagcagaa gatctcttaa ggagcagcat ttcttttcct   5760

tcagggaaaa aaataggggt cctctctctt gaaagtcttc atgcatccac aaggtcatct   5820

gctagacaag cacttggtat aactattgtt cggcagcctg gtcgaagagg aactggtgac   5880

ttacagctag agccttttct gtactttatt gtgtcccagc cttccttgct tctgagttgt   5940

caccacagaa agcagcgagt ggaagtatcc atttttgatg ctgtgcttaa aggggtggcc   6000

tctgattaca aatgtataga tcctgggaag actctgcctg aagcccttga ttattgcact   6060

gtttggctac agacagtgcc tggagaaata gacagcaaaa gtggtattcc accttccttt   6120

ataacactac agattaaaga ctttctgaat ggaccagcgg atgtcaattt ggatatatca   6180

aagcctttga aagcaaacct gagtttcacc aaactggatc agataaacct ttttttaaag   6240

aagataaaaa atgcacacag tttggcacat agtgaagaga cttcagccat gtccaacacc   6300

atggtgaata aggatgatct tccagtctcc aaatattacc gtggaaagtt gtctaaaccc   6360

aaaattcatg gtgatggagt gcaaaagatt tcagctcaag aaaacatgtg gagagctgtt   6420

tcctgctttc aaaaaatttc tgttcaaact actcagattg tgatctccat ggaaactgta   6480

ccccatacca gcaaaccatg cctgttagca tctctctcaa acctcaatgg aagccttagt   6540

gtcaaggcaa cacaaaaagt acctggcata attcttgggt catcatttct actcagtata   6600

aacgattttc tccttaaaac aagtctcaaa gaaagaagcc gcattctgat aggaccatgt   6660

tgtgctactg ccaatctgga agctaagtgg tgtaaacaca gcgggaatcc aggcccagaa   6720

caatccatac caaaaatatc cattgactta agaggaggtc tactacaggt cttctggggt   6780

caagaacatt tgaattgttt agttcttcta catgaattac tcaatggata ccttaatgag   6840

gagggaaatt ttgaagtaca agtttctgaa ccagtgcctc aaatgtcatc tcctgtggaa   6900

aagaatcaga catttaaaag tgaacaaagt tcagatgacc tacggacagg tctatttcag   6960

tatgtacagg atgctgaatc tttgaaattg cctggggtct atgaagtctt attttataat   7020

gaaactgaag attgcccagg gatgatgtta tggagatatc cagaacctag agtactcacc   7080

cttgtacgaa taactcctgt accttttaac accacagagg atccagatat tagcacagca   7140

gaccttggtg atgtgctaca ggttccttgt agcttggaat actgggatga actccagaag   7200

gtttttgttg catttagaga atttaatctg tctgaaagca aagtttgtga actgcagttg   7260

ccggatatca atctcgtgaa tgaccagaag aaattagtat cttcagatct ttggagaatt   7320

gtcttgaaca gcagtcaaaa tggagctgat gaccaaagct ctgcaagtga gtctggttct   7380

caaagcactt gtgatccact tgtgactcca acagccctgg ctgcctgtac cagagttgac   7440

tcctgcttta ccccatggtt tgtcccatcc ctttgcgttt ctttccagtt tgctcacctg   7500

gaattccatc tttgtcatca ccttgaccaa ctaggcacag ctgcaccaca gtacctacag   7560

ccatttgttt ccgacagaaa tatgccatct gaactagaat acatgattgt ttccttcaga   7620

gaaccacaca tgtatcttcg acagtggaat aatggttctg tctgtcagga gatccagttc   7680

ttagctcaag cagactgtaa acttctagag tgcagaaatg tcactatgca aagtgtggtg   7740

aaacccttca gcatcttcgg gcagatggca gtttccagcg atgtagtgga aaagctgctt   7800

gactgcaccg tgatagttga ttctgtattt gtaaaccttg gacagcatgt agtccattca   7860

ctaaacactg caatacaagc ttggcaacag aacaaatgcc ctgaggtaga ggagttggtc   7920

ttcagccatt ttgtgatctg taatgacaca caggagacac tgcggtttgg ccaggtggat   7980

actgatgaaa atattctgct ggcgagtctc cacagtcacc agtacagctg gcgctctcac   8040

aaatccccac agctgttaca catctgtatt gaaggttggg gcaactggcg ttggtcagag   8100

cctttcagtg tggaccatgc cgggactttt attagaacaa ttcagtacag gggtcgaact   8160

gcttctctca tcatcaaggt tcagcaactc aa                                 8192


<210>  1638
<211>  3997
<212>  PRT
<213>  Homosapiens

<400>  1638

Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg 
1               5                   10                  15      


Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly 
            20                  25                  30          


Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu 
        35                  40                  45              


Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu 
    50                  55                  60                  


Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val 
65                  70                  75                  80  


Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile 
                85                  90                  95      


Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr 
            100                 105                 110         


Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala 
        115                 120                 125             


Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile 
    130                 135                 140                 


Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu 
145                 150                 155                 160 


Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala 
                165                 170                 175     


Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile 
            180                 185                 190         


Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys 
        195                 200                 205             


Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr 
    210                 215                 220                 


Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe 
225                 230                 235                 240 


Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His 
                245                 250                 255     


Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro 
            260                 265                 270         


Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu 
        275                 280                 285             


Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn 
    290                 295                 300                 


Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln 
                325                 330                 335     


Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe 
            340                 345                 350         


Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly 
        355                 360                 365             


Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys 
    370                 375                 380                 


Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr 
385                 390                 395                 400 


Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln 
                405                 410                 415     


Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr 
            420                 425                 430         


Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly 
        435                 440                 445             


Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys 
    450                 455                 460                 


Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe 
465                 470                 475                 480 


Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn 
                485                 490                 495     


Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu 
            500                 505                 510         


Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala 
        515                 520                 525             


Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Met 
    530                 535                 540                 


Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser 
545                 550                 555                 560 


Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser 
                565                 570                 575     


Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His 
            580                 585                 590         


Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro 
        595                 600                 605             


Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asp Glu Asn Glu Thr Ile Leu 
    610                 615                 620                 


Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His 
625                 630                 635                 640 


Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu 
                645                 650                 655     


Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn 
            660                 665                 670         


Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu 
        675                 680                 685             


Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val 
    690                 695                 700                 


Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln 
705                 710                 715                 720 


Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys 
                725                 730                 735     


Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser 
            740                 745                 750         


Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr 
        755                 760                 765             


Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile 
    770                 775                 780                 


Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala 
785                 790                 795                 800 


Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser 
                805                 810                 815     


His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn 
            820                 825                 830         


Glu Ile Phe Leu Ser Ile Gly Val Lys Ser Lys Asn Pro Leu Pro Thr 
        835                 840                 845             


Leu Glu Gly Ser Ile Gln Asn Val Glu Leu Lys Tyr Cys Ser Thr Ser 
    850                 855                 860                 


Leu Val Lys Cys Ala Ser Gly Thr Met Gly Ser Ile Lys Ile Cys Ala 
865                 870                 875                 880 


Lys Ala Pro Val Asp Ser Gly Lys Glu Lys Leu Ile Pro Leu Leu Gln 
                885                 890                 895     


Gly Pro Ser Asp Thr Lys Asp Leu His Ser Thr Lys Trp Leu Asn Glu 
            900                 905                 910         


Ser Arg Lys Pro Glu Ser Leu Leu Ala Pro Asp Leu Met Ala Phe Thr 
        915                 920                 925             


Ile Gln Val Pro Gln Tyr Ile Asp Tyr Cys His Asn Ser Gly Ala Val 
    930                 935                 940                 


Leu Leu Cys Ser Ile Gln Gly Leu Ala Val Asn Ile Asp Pro Ile Leu 
945                 950                 955                 960 


Tyr Thr Trp Leu Ile Tyr Gln Pro Gln Lys Arg Thr Ser Arg His Met 
                965                 970                 975     


Gln Gln Gln Pro Val Val Ala Val Pro Leu Val Met Pro Val Cys Arg 
            980                 985                 990         


Arg Lys Glu Asp Glu Val Ser Ile  Gly Ser Ala Pro Leu  Ala Lys Gln 
        995                 1000                 1005             


Gln Ser  Tyr Gln Ala Ser Glu  Tyr Ala Ser Ser Pro  Val Lys Thr 
    1010                 1015                 1020             


Lys Thr  Val Thr Glu Ser Arg  Pro Leu Ser Val Pro  Val Lys Ala 
    1025                 1030                 1035             


Met Leu  Asn Ile Ser Glu Ser  Cys Arg Ser Pro Glu  Glu Arg Met 
    1040                 1045                 1050             


Lys Glu  Phe Ile Gly Ile Val  Trp Asn Ala Val Lys  His Leu Thr 
    1055                 1060                 1065             


Leu Gln  Leu Glu Val Gln Ser  Cys Cys Val Phe Ile  Pro Asn Asp 
    1070                 1075                 1080             


Ser Leu  Pro Ser Pro Ser Thr  Ile Val Ser Gly Asp  Ile Pro Gly 
    1085                 1090                 1095             


Thr Val  Arg Ser Trp Tyr His  Gly Gln Thr Ser Met  Pro Gly Thr 
    1100                 1105                 1110             


Leu Val  Leu Cys Leu Pro Gln  Ile Lys Ile Ile Ser  Ala Gly His 
    1115                 1120                 1125             


Lys Tyr  Met Glu Pro Leu Gln  Glu Ile Pro Phe Val  Ile Pro Arg 
    1130                 1135                 1140             


Pro Ile  Leu Glu Glu Gly Asp  Ala Phe Pro Trp Thr  Ile Ser Leu 
    1145                 1150                 1155             


His Asn  Phe Ser Ile Tyr Thr  Leu Leu Gly Lys Gln  Val Thr Leu 
    1160                 1165                 1170             


Cys Leu  Val Glu Pro Met Gly  Cys Thr Ser Thr Leu  Ala Val Thr 
    1175                 1180                 1185             


Ser Gln  Lys Leu Leu Ala Thr  Gly Pro Asp Thr Arg  His Ser Phe 
    1190                 1195                 1200             


Val Val  Cys Leu His Val Asp  Leu Glu Ser Leu Glu  Ile Lys Cys 
    1205                 1210                 1215             


Ser Asn  Pro Gln Val Gln Leu  Phe Tyr Glu Leu Thr  Asp Ile Met 
    1220                 1225                 1230             


Asn Lys  Val Trp Asn Lys Ile  Gln Lys Arg Gly Asn  Leu Asn Leu 
    1235                 1240                 1245             


Ser Pro  Thr Ser Pro Glu Thr  Met Ala Gly Pro Val  Pro Thr Ser 
    1250                 1255                 1260             


Pro Val  Arg Ser Ser Ile Gly  Thr Ala Pro Pro Asp  Thr Ser Thr 
    1265                 1270                 1275             


Cys Ser  Pro Ser Ala Asp Ile  Gly Thr Thr Thr Glu  Gly Asp Ser 
    1280                 1285                 1290             


Ile Gln  Ala Gly Glu Glu Ser  Pro Phe Ser Asp Ser  Val Thr Leu 
    1295                 1300                 1305             


Glu Gln  Thr Thr Ser Asn Ile  Gly Gly Thr Ser Gly  Arg Val Ser 
    1310                 1315                 1320             


Leu Trp  Met Gln Trp Val Leu  Pro Lys Ile Thr Ile  Lys Leu Phe 
    1325                 1330                 1335             


Ala Pro  Asp Pro Glu Asn Lys  Gly Thr Glu Val Cys  Met Val Ser 
    1340                 1345                 1350             


Glu Leu  Glu Asp Leu Ser Ala  Ser Ile Asp Val Gln  Asp Val Tyr 
    1355                 1360                 1365             


Thr Lys  Val Lys Cys Lys Ile  Glu Ser Phe Asn Ile  Asp His Tyr 
    1370                 1375                 1380             


Arg Ser  Arg Pro Gly Glu Gly  Trp Gln Ser Gly His  Phe Glu Gly 
    1385                 1390                 1395             


Val Phe  Leu Gln Cys Lys Glu  Lys Ser Val Thr Thr  Thr Lys Leu 
    1400                 1405                 1410             


Leu Asp  Gly Thr His Gln Gln  His Gly Phe Leu Ser  Leu Thr Tyr 
    1415                 1420                 1425             


Thr Lys  Ala Val Thr Lys Asn  Val Arg His Lys Leu  Thr Ser Arg 
    1430                 1435                 1440             


Asn Glu  Arg Arg Ser Phe His  Lys Leu Ser Glu Gly  Leu Met Asp 
    1445                 1450                 1455             


Gly Ser  Pro His Phe Leu His  Glu Ile Leu Leu Ser  Ala Gln Ala 
    1460                 1465                 1470             


Phe Asp  Ile Val Leu Tyr Phe  Pro Leu Leu Asn Ala  Ile Ala Ser 
    1475                 1480                 1485             


Ile Phe  Gln Ala Lys Leu Pro  Lys Thr Gln Lys Glu  Lys Arg Lys 
    1490                 1495                 1500             


Ser Pro  Gly Gln Pro Met Arg  Thr His Thr Leu Thr  Ser Arg Asn 
    1505                 1510                 1515             


Leu Pro  Leu Ile Tyr Val Asn  Thr Ser Val Ile Arg  Ile Phe Ile 
    1520                 1525                 1530             


Pro Lys  Thr Glu Glu Met Gln  Pro Thr Val Glu Ala  Asn Gln Ala 
    1535                 1540                 1545             


Ala Lys  Glu Asp Thr Val Val  Leu Lys Ile Gly Ser  Val Ala Met 
    1550                 1555                 1560             


Ala Pro  Gln Ala Asp Asn Pro  Leu Gly Arg Ser Val  Leu Arg Lys 
    1565                 1570                 1575             


Asp Ile  Tyr Gln Arg Ala Leu  Asn Leu Gly Ile Leu  Arg Asp Pro 
    1580                 1585                 1590             


Gly Ser  Glu Ile Glu Asp Arg  Gln Tyr Gln Ile Asp  Leu Gln Ser 
    1595                 1600                 1605             


Ile Asn  Ile Gly Thr Ala Gln  Trp His Gln Leu Lys  Pro Glu Lys 
    1610                 1615                 1620             


Glu Ser  Val Ser Gly Gly Val  Val Thr Glu Thr Glu  Arg Asn Ser 
    1625                 1630                 1635             


Gln Asn  Pro Ala Leu Glu Trp  Asn Met Ala Ser Ser  Ile Arg Arg 
    1640                 1645                 1650             


His Gln  Glu Arg Arg Ala Ile  Leu Thr Pro Val Leu  Thr Asp Phe 
    1655                 1660                 1665             


Ser Val  Arg Ile Thr Gly Ala  Pro Ala Val Ile Phe  Thr Lys Val 
    1670                 1675                 1680             


Val Ser  Pro Glu Asn Leu His  Thr Glu Glu Ile Leu  Val Cys Gly 
    1685                 1690                 1695             


His Ser  Leu Glu Val Asn Ile  Thr Thr Asn Leu Asp  Phe Phe Leu 
    1700                 1705                 1710             


Ser Val  Ala Gln Val Gln Leu  Leu His Gln Leu Ile  Val Ala Asn 
    1715                 1720                 1725             


Met Thr  Gly Leu Glu Pro Ser  Asn Lys Ala Ala Glu  Ile Ser Lys 
    1730                 1735                 1740             


Gln Glu  Gln Lys Lys Val Asp  Ile Phe Asp Gly Gly  Met Ala Glu 
    1745                 1750                 1755             


Thr Ser  Ser Arg Tyr Ser Gly  Ala Gln Asp Ser Gly  Ile Gly Ser 
    1760                 1765                 1770             


Asp Ser  Val Lys Ile Arg Ile  Val Gln Ile Glu Gln  His Ser Gly 
    1775                 1780                 1785             


Ala Ser  Gln His Arg Ile Ala  Arg Pro Ser Arg Gln  Ser Ser Ile 
    1790                 1795                 1800             


Val Lys  Asn Leu Asn Phe Ile  Pro Phe Asp Ile Phe  Ile Thr Ala 
    1805                 1810                 1815             


Ser Arg  Ile Ser Leu Met Thr  Tyr Ser Cys Met Ala  Leu Ser Lys 
    1820                 1825                 1830             


Ser Lys  Ser Gln Glu Gln Lys  Asn Asn Glu Lys Thr  Asp Lys Ser 
    1835                 1840                 1845             


Ser Leu  Asn Leu Pro Glu Val  Asp Ser Asp Val Ala  Lys Pro Asn 
    1850                 1855                 1860             


Gln Ala  Cys Ile Ser Thr Val  Thr Ala Glu Asp Leu  Leu Arg Ser 
    1865                 1870                 1875             


Ser Ile  Ser Phe Pro Ser Gly  Lys Lys Ile Gly Val  Leu Ser Leu 
    1880                 1885                 1890             


Glu Ser  Leu His Ala Ser Thr  Arg Ser Ser Ala Arg  Gln Ala Leu 
    1895                 1900                 1905             


Gly Ile  Thr Ile Val Arg Gln  Pro Gly Arg Arg Gly  Thr Gly Asp 
    1910                 1915                 1920             


Leu Gln  Leu Glu Pro Phe Leu  Tyr Phe Ile Val Ser  Gln Pro Ser 
    1925                 1930                 1935             


Leu Leu  Leu Ser Cys His His  Arg Lys Gln Arg Val  Glu Val Ser 
    1940                 1945                 1950             


Ile Phe  Asp Ala Val Leu Lys  Gly Val Ala Ser Asp  Tyr Lys Cys 
    1955                 1960                 1965             


Ile Asp  Pro Gly Lys Thr Leu  Pro Glu Ala Leu Asp  Tyr Cys Thr 
    1970                 1975                 1980             


Val Trp  Leu Gln Thr Val Pro  Gly Glu Ile Asp Ser  Lys Ser Gly 
    1985                 1990                 1995             


Ile Pro  Pro Ser Phe Ile Thr  Leu Gln Ile Lys Asp  Phe Leu Asn 
    2000                 2005                 2010             


Gly Pro  Ala Asp Val Asn Leu  Asp Ile Ser Lys Pro  Leu Lys Ala 
    2015                 2020                 2025             


Asn Leu  Ser Phe Thr Lys Leu  Asp Gln Ile Asn Leu  Phe Leu Lys 
    2030                 2035                 2040             


Lys Ile  Lys Asn Ala His Ser  Leu Ala His Ser Glu  Glu Thr Ser 
    2045                 2050                 2055             


Ala Met  Ser Asn Thr Met Val  Asn Lys Asp Asp Leu  Pro Val Ser 
    2060                 2065                 2070             


Lys Tyr  Tyr Arg Gly Lys Leu  Ser Lys Pro Lys Ile  His Gly Asp 
    2075                 2080                 2085             


Gly Val  Gln Lys Ile Ser Ala  Gln Glu Asn Met Trp  Arg Ala Val 
    2090                 2095                 2100             


Ser Cys  Phe Gln Lys Ile Ser  Val Gln Thr Thr Gln  Ile Val Ile 
    2105                 2110                 2115             


Ser Met  Glu Thr Val Pro His  Thr Ser Lys Pro Cys  Leu Leu Ala 
    2120                 2125                 2130             


Ser Leu  Ser Asn Leu Asn Gly  Ser Leu Ser Val Lys  Ala Thr Gln 
    2135                 2140                 2145             


Lys Val  Pro Gly Ile Ile Leu  Gly Ser Ser Phe Leu  Leu Ser Ile 
    2150                 2155                 2160             


Asn Asp  Phe Leu Leu Lys Thr  Ser Leu Lys Glu Arg  Ser Arg Ile 
    2165                 2170                 2175             


Leu Ile  Gly Pro Cys Cys Ala  Thr Ala Asn Leu Glu  Ala Lys Trp 
    2180                 2185                 2190             


Cys Lys  His Ser Gly Asn Pro  Gly Pro Glu Gln Ser  Ile Pro Lys 
    2195                 2200                 2205             


Ile Ser  Ile Asp Leu Arg Gly  Gly Leu Leu Gln Val  Phe Trp Gly 
    2210                 2215                 2220             


Gln Glu  His Leu Asn Cys Leu  Val Leu Leu His Glu  Leu Leu Asn 
    2225                 2230                 2235             


Gly Tyr  Leu Asn Glu Glu Gly  Asn Phe Glu Val Gln  Val Ser Glu 
    2240                 2245                 2250             


Pro Val  Pro Gln Met Ser Ser  Pro Val Glu Lys Asn  Gln Thr Phe 
    2255                 2260                 2265             


Lys Ser  Glu Gln Ser Ser Asp  Asp Leu Arg Thr Gly  Leu Phe Gln 
    2270                 2275                 2280             


Tyr Val  Gln Asp Ala Glu Ser  Leu Lys Leu Pro Gly  Val Tyr Glu 
    2285                 2290                 2295             


Val Leu  Phe Tyr Asn Glu Thr  Glu Asp Cys Pro Gly  Met Met Leu 
    2300                 2305                 2310             


Trp Arg  Tyr Pro Glu Pro Arg  Val Leu Thr Leu Val  Arg Ile Thr 
    2315                 2320                 2325             


Pro Val  Pro Phe Asn Thr Thr  Glu Asp Pro Asp Ile  Ser Thr Ala 
    2330                 2335                 2340             


Asp Leu  Gly Asp Val Leu Gln  Val Pro Cys Ser Leu  Glu Tyr Trp 
    2345                 2350                 2355             


Asp Glu  Leu Gln Lys Val Phe  Val Ala Phe Arg Glu  Phe Asn Leu 
    2360                 2365                 2370             


Ser Glu  Ser Lys Val Cys Glu  Leu Gln Leu Pro Asp  Ile Asn Leu 
    2375                 2380                 2385             


Val Asn  Asp Gln Lys Lys Leu  Val Ser Ser Asp Leu  Trp Arg Ile 
    2390                 2395                 2400             


Val Leu  Asn Ser Ser Gln Asn  Gly Ala Asp Asp Gln  Ser Ser Ala 
    2405                 2410                 2415             


Ser Glu  Ser Gly Ser Gln Ser  Thr Cys Asp Pro Leu  Val Thr Pro 
    2420                 2425                 2430             


Thr Ala  Leu Ala Ala Cys Thr  Arg Val Asp Ser Cys  Phe Thr Pro 
    2435                 2440                 2445             


Trp Phe  Val Pro Ser Leu Cys  Val Ser Phe Gln Phe  Ala His Leu 
    2450                 2455                 2460             


Glu Phe  His Leu Cys His His  Leu Asp Gln Leu Gly  Thr Ala Ala 
    2465                 2470                 2475             


Pro Gln  Tyr Leu Gln Pro Phe  Val Ser Asp Arg Asn  Met Pro Ser 
    2480                 2485                 2490             


Glu Leu  Glu Tyr Met Ile Val  Ser Phe Arg Glu Pro  His Met Tyr 
    2495                 2500                 2505             


Leu Arg  Gln Trp Asn Asn Gly  Ser Val Cys Gln Glu  Ile Gln Phe 
    2510                 2515                 2520             


Leu Ala  Gln Ala Asp Cys Lys  Leu Leu Glu Cys Arg  Asn Val Thr 
    2525                 2530                 2535             


Met Gln  Ser Val Val Lys Pro  Phe Ser Ile Phe Gly  Gln Met Ala 
    2540                 2545                 2550             


Val Ser  Ser Asp Val Val Glu  Lys Leu Leu Asp Cys  Thr Val Ile 
    2555                 2560                 2565             


Val Asp  Ser Val Phe Val Asn  Leu Gly Gln His Val  Val His Ser 
    2570                 2575                 2580             


Leu Asn  Thr Ala Ile Gln Ala  Trp Gln Gln Asn Lys  Cys Pro Glu 
    2585                 2590                 2595             


Val Glu  Glu Leu Val Phe Ser  His Phe Val Ile Cys  Asn Asp Thr 
    2600                 2605                 2610             


Gln Glu  Thr Leu Arg Phe Gly  Gln Val Asp Thr Asp  Glu Asn Ile 
    2615                 2620                 2625             


Leu Leu  Ala Ser Leu His Ser  His Gln Tyr Ser Trp  Arg Ser His 
    2630                 2635                 2640             


Lys Ser  Pro Gln Leu Leu His  Ile Cys Ile Glu Gly  Trp Gly Asn 
    2645                 2650                 2655             


Trp Arg  Trp Ser Glu Pro Phe  Ser Val Asp His Ala  Gly Thr Phe 
    2660                 2665                 2670             


Ile Arg  Thr Ile Gln Tyr Arg  Gly Arg Thr Ala Ser  Leu Ile Ile 
    2675                 2680                 2685             


Lys Val  Gln Gln Leu Asn Gly  Val Gln Lys Gln Ile  Ile Ile Cys 
    2690                 2695                 2700             


Gly Arg  Gln Ile Ile Cys Ser  Tyr Leu Ser Gln Ser  Ile Glu Leu 
    2705                 2710                 2715             


Lys Val  Val Gln His Tyr Ile  Gly Gln Asp Gly Gln  Ala Val Val 
    2720                 2725                 2730             


Arg Glu  His Phe Asp Cys Leu  Thr Ala Lys Gln Lys  Leu Pro Ser 
    2735                 2740                 2745             


Tyr Ile  Leu Glu Asn Asn Glu  Leu Thr Glu Leu Cys  Val Lys Ala 
    2750                 2755                 2760             


Lys Gly  Asp Glu Asp Trp Ser  Arg Asp Val Cys Leu  Glu Ser Lys 
    2765                 2770                 2775             


Ala Pro  Glu Tyr Ser Ile Val  Ile Gln Val Pro Ser  Ser Asn Ser 
    2780                 2785                 2790             


Ser Ile  Ile Tyr Val Trp Cys  Thr Val Leu Thr Leu  Glu Pro Asn 
    2795                 2800                 2805             


Ser Gln  Val Gln Gln Arg Met  Ile Val Phe Ser Pro  Leu Phe Ile 
    2810                 2815                 2820             


Met Arg  Ser His Leu Pro Asp  Pro Ile Ile Ile His  Leu Glu Lys 
    2825                 2830                 2835             


Arg Ser  Leu Gly Leu Ser Glu  Thr Gln Ile Ile Pro  Gly Lys Gly 
    2840                 2845                 2850             


Gln Glu  Lys Pro Leu Gln Asn  Ile Glu Pro Asp Leu  Val His His 
    2855                 2860                 2865             


Leu Thr  Phe Gln Ala Arg Glu  Glu Tyr Asp Pro Ser  Asp Cys Ala 
    2870                 2875                 2880             


Val Pro  Ile Ser Thr Ser Leu  Ile Lys Gln Ile Ala  Thr Lys Val 
    2885                 2890                 2895             


His Pro  Gly Gly Thr Val Asn  Gln Ile Leu Asp Glu  Phe Tyr Gly 
    2900                 2905                 2910             


Pro Glu  Lys Ser Leu Gln Pro  Ile Trp Pro Tyr Asn  Lys Lys Asp 
    2915                 2920                 2925             


Ser Asp  Arg Asn Glu Gln Leu  Ser Gln Trp Asp Ser  Pro Met Arg 
    2930                 2935                 2940             


Val Lys  Leu Ser Ile Trp Lys  Pro Tyr Val Arg Thr  Leu Leu Ile 
    2945                 2950                 2955             


Glu Leu  Leu Pro Trp Ala Leu  Leu Ile Asn Glu Ser  Lys Trp Asp 
    2960                 2965                 2970             


Leu Trp  Leu Phe Glu Gly Glu  Lys Ile Val Leu Gln  Val Pro Ala 
    2975                 2980                 2985             


Gly Lys  Ile Ile Ile Pro Pro  Asn Phe Gln Glu Ala  Phe Gln Ile 
    2990                 2995                 3000             


Gly Ile  Tyr Trp Ala Asn Thr  Asn Thr Val His Lys  Ser Val Ala 
    3005                 3010                 3015             


Ile Lys  Leu Val His Asn Leu  Thr Ser Pro Lys Trp  Lys Asp Gly 
    3020                 3025                 3030             


Gly Asn  Gly Glu Val Val Thr  Leu Asp Glu Glu Ala  Phe Val Asp 
    3035                 3040                 3045             


Thr Glu  Ile Arg Leu Gly Ala  Phe Pro Gly His Gln  Lys Leu Cys 
    3050                 3055                 3060             


Gln Phe  Cys Ile Ser Ser Met  Val Gln Gln Gly Ile  Gln Ile Ile 
    3065                 3070                 3075             


Gln Ile  Glu Asp Lys Thr Thr  Ile Ile Asn Asn Thr  Pro Tyr Gln 
    3080                 3085                 3090             


Ile Phe  Tyr Lys Pro Gln Leu  Ser Val Cys Asn Pro  His Ser Gly 
    3095                 3100                 3105             


Lys Glu  Tyr Phe Arg Val Pro  Asp Ser Ala Thr Phe  Ser Ile Cys 
    3110                 3115                 3120             


Pro Gly  Gly Glu Gln Pro Ala  Met Lys Ser Ser Ser  Leu Pro Cys 
    3125                 3130                 3135             


Trp Asp  Leu Met Pro Asp Ile  Ser Gln Ser Val Leu  Asp Ala Ser 
    3140                 3145                 3150             


Leu Leu  Gln Lys Gln Ile Met  Leu Gly Phe Ser Pro  Ala Pro Gly 
    3155                 3160                 3165             


Ala Asp  Ser Ser Gln Cys Trp  Ser Leu Pro Ala Ile  Val Arg Pro 
    3170                 3175                 3180             


Glu Phe  Pro Arg Gln Ser Val  Ala Val Pro Leu Gly  Asn Phe Arg 
    3185                 3190                 3195             


Glu Asn  Gly Phe Cys Thr Arg  Ala Ile Val Leu Thr  Tyr Gln Glu 
    3200                 3205                 3210             


His Leu  Gly Val Thr Tyr Leu  Thr Leu Ser Glu Asp  Pro Ser Pro 
    3215                 3220                 3225             


Arg Val  Ile Ile His Asn Arg  Cys Pro Val Lys Met  Leu Ile Lys 
    3230                 3235                 3240             


Glu Asn  Ile Lys Asp Ile Pro  Lys Phe Glu Val Tyr  Cys Lys Lys 
    3245                 3250                 3255             


Ile Pro  Ser Glu Cys Ser Ile  His His Glu Leu Tyr  His Gln Ile 
    3260                 3265                 3270             


Ser Ser  Tyr Pro Asp Cys Lys  Thr Lys Asp Leu Leu  Pro Ser Leu 
    3275                 3280                 3285             


Leu Leu  Arg Val Glu Pro Leu  Asp Glu Val Thr Thr  Glu Trp Ser 
    3290                 3295                 3300             


Asp Ala  Ile Asp Ile Asn Ser  Gln Gly Thr Gln Val  Val Phe Leu 
    3305                 3310                 3315             


Thr Gly  Phe Gly Tyr Val Tyr  Val Asp Val Val His  Gln Cys Gly 
    3320                 3325                 3330             


Thr Val  Phe Ile Thr Val Ala  Pro Glu Gly Lys Ala  Gly Pro Ile 
    3335                 3340                 3345             


Leu Thr  Asn Thr Asn Arg Ala  Pro Glu Lys Ile Val  Thr Phe Lys 
    3350                 3355                 3360             


Met Phe  Ile Thr Gln Leu Ser  Leu Ala Val Phe Asp  Asp Leu Thr 
    3365                 3370                 3375             


His His  Lys Ala Ser Ala Glu  Leu Leu Arg Leu Thr  Leu Asp Asn 
    3380                 3385                 3390             


Ile Phe  Leu Cys Val Ala Pro  Gly Ala Gly Pro Leu  Pro Gly Glu 
    3395                 3400                 3405             


Glu Pro  Val Ala Ala Leu Phe  Glu Leu Tyr Cys Val  Glu Ile Cys 
    3410                 3415                 3420             


Cys Gly  Asp Leu Gln Leu Asp  Asn Gln Leu Tyr Asn  Lys Ser Asn 
    3425                 3430                 3435             


Phe His  Phe Ala Val Leu Val  Cys Gln Gly Glu Lys  Ala Glu Pro 
    3440                 3445                 3450             


Ile Gln  Cys Ser Lys Met Gln  Ser Leu Leu Ile Ser  Asn Lys Glu 
    3455                 3460                 3465             


Leu Glu  Glu Tyr Lys Glu Lys  Cys Phe Ile Lys Leu  Cys Ile Thr 
    3470                 3475                 3480             


Leu Asn  Glu Gly Lys Ser Ile  Leu Cys Asp Ile Asn  Glu Phe Ser 
    3485                 3490                 3495             


Phe Glu  Leu Lys Pro Ala Arg  Leu Tyr Val Glu Asp  Thr Phe Val 
    3500                 3505                 3510             


Tyr Tyr  Ile Lys Thr Leu Phe  Asp Thr Tyr Leu Pro  Asn Ser Arg 
    3515                 3520                 3525             


Leu Ala  Gly His Ser Thr His  Leu Ser Gly Gly Lys  Gln Val Leu 
    3530                 3535                 3540             


Pro Met  Gln Val Thr Gln His  Ala Arg Ala Leu Val  Asn Pro Val 
    3545                 3550                 3555             


Lys Leu  Arg Lys Leu Val Ile  Gln Pro Val Asn Leu  Leu Val Ser 
    3560                 3565                 3570             


Ile His  Ala Ser Leu Lys Leu  Tyr Ile Ala Ser Asp  His Thr Pro 
    3575                 3580                 3585             


Leu Ser  Phe Ser Val Phe Glu  Arg Gly Pro Ile Phe  Thr Thr Ala 
    3590                 3595                 3600             


Arg Gln  Leu Val His Ala Leu  Ala Met His Tyr Ala  Ala Gly Ala 
    3605                 3610                 3615             


Leu Phe  Arg Ala Gly Trp Val  Val Gly Ser Leu Asp  Ile Leu Gly 
    3620                 3625                 3630             


Ser Pro  Ala Ser Leu Val Arg  Ser Ile Gly Asn Gly  Val Ala Asp 
    3635                 3640                 3645             


Phe Phe  Arg Leu Pro Tyr Glu  Gly Leu Thr Arg Gly  Pro Gly Ala 
    3650                 3655                 3660             


Phe Val  Ser Gly Val Ser Arg  Gly Thr Thr Ser Phe  Val Lys His 
    3665                 3670                 3675             


Ile Ser  Lys Gly Thr Leu Thr  Ser Ile Thr Asn Leu  Ala Thr Ser 
    3680                 3685                 3690             


Leu Ala  Arg Asn Met Asp Arg  Leu Ser Leu Asp Glu  Glu His Tyr 
    3695                 3700                 3705             


Asn Arg  Gln Glu Glu Trp Arg  Arg Gln Leu Pro Glu  Ser Leu Gly 
    3710                 3715                 3720             


Glu Gly  Leu Arg Gln Gly Leu  Ser Arg Leu Gly Ile  Ser Leu Leu 
    3725                 3730                 3735             


Gly Ala  Ile Ala Gly Ile Val  Asp Gln Pro Met Gln  Asn Phe Gln 
    3740                 3745                 3750             


Lys Thr  Ser Glu Ala Gln Ala  Ser Ala Gly His Lys  Ala Lys Gly 
    3755                 3760                 3765             


Val Ile  Ser Gly Val Gly Lys  Gly Ile Met Gly Val  Phe Thr Lys 
    3770                 3775                 3780             


Pro Ile  Gly Gly Ala Ala Glu  Leu Val Ser Gln Thr  Gly Tyr Gly 
    3785                 3790                 3795             


Ile Leu  His Gly Ala Gly Leu  Ser Gln Leu Pro Lys  Gln Arg His 
    3800                 3805                 3810             


Gln Pro  Ser Asp Leu His Ala  Asp Gln Ala Pro Asn  Ser His Val 
    3815                 3820                 3825             


Lys Tyr  Val Trp Lys Met Leu  Gln Ser Leu Gly Arg  Pro Glu Val 
    3830                 3835                 3840             


His Met  Ala Leu Asp Val Val  Leu Val Arg Gly Ser  Gly Gln Glu 
    3845                 3850                 3855             


His Glu  Gly Cys Leu Leu Leu  Thr Ser Glu Val Leu  Phe Val Val 
    3860                 3865                 3870             


Ser Val  Ser Glu Asp Thr Gln  Gln Gln Ala Phe Pro  Val Thr Glu 
    3875                 3880                 3885             


Ile Asp  Cys Ala Gln Asp Ser  Lys Gln Asn Asn Leu  Leu Thr Val 
    3890                 3895                 3900             


Gln Leu  Lys Gln Pro Arg Val  Ala Cys Asp Val Glu  Val Asp Gly 
    3905                 3910                 3915             


Val Arg  Glu Arg Leu Ser Glu  Gln Gln Tyr Asn Arg  Leu Val Asp 
    3920                 3925                 3930             


Tyr Ile  Thr Lys Thr Ser Cys  His Leu Ala Pro Ser  Cys Ser Ser 
    3935                 3940                 3945             


Met Gln  Ile Pro Cys Pro Val  Val Ala Ala Glu Pro  Pro Pro Ser 
    3950                 3955                 3960             


Thr Val  Lys Thr Tyr His Tyr  Leu Val Asp Pro His  Phe Ala Gln 
    3965                 3970                 3975             


Val Phe  Leu Ser Lys Phe Thr  Met Val Lys Asn Lys  Ala Leu Arg 
    3980                 3985                 3990             


Lys Gly  Phe Pro 
    3995         


<210>  1639
<211>  1629
<212>  DNA
<213>  Homosapiens

<400>  1639
ggcgcggtac aggagcagca ctgccggcgg gggcgggtgc cagggacttg gaggtggagg     60

ggacgcggcg gtactctggc gtcttccgac ttcgactcct taccttaaaa gatgctggag    120

tcatatgtaa ctccaatttt aatgagctat gtgaatcgct acatcaagaa cttaaagccg    180

tcggatctac agctttcact atggggtgga gacgtggtac tcagcaagct cgagttaaag    240

ttggatgtgc tggaacagga actgaaatta ccattcactt ttttaagtgg acatattcat    300

gaattgagga ttcatgtacc atggacaaaa ctgggttcag aaccagtggt aattaccatc    360

aatactatgg aatgcatttt gaaacttaag gatgggatac aggatgacca tgaaagctgt    420

ggttctaatt ctaccaaccg tagtactgct gagagcacaa aatcatcaat caaaccgcgg    480

agaatgcagc aggctgctcc tacagatcct gacttaccac caggttatgt gcagagtctg    540

attagacgag ttgtaaataa tgtaaacatt gtgataaata atctcatact aaaatatgtt    600

gaagatgata tcgtcctttc cgtcaatatc acttctgcag aatgttatac agtaggtgaa    660

ttatgggatc gtgcattcat ggatatttct gcaactgatt tggtgctgag aaaggttatc    720

aatttttctg actgtacagt ttgtcttgat aaacggaatg ccagtggtaa aatagaattt    780

taccaggatc ctttattata caaatgttcc ttcagaactc gtcttcattt tacatatgaa    840

aacctaaatt ccaagatgcc atctgttatt aaaattcata ctttagtgga aagtttgaaa    900

ctttctatca cagatcaaca actgcctatg tttattcgta taatgcaact tggaattgct    960

ctttactatg gagaaatagg caattttaaa gaaggcgaaa tagaggacct tacttgtcat   1020

aataaagata tgctaggaaa cattacaggt tctgaagatg aaacaagaat agatatgcaa   1080

tatcctgctc agcataaagg tcaagagtta tattcacagc aagatgagga gcagccacag   1140

ggatgggtgt catgggcctg gtcctttgtg cctgcaattg tgagttatga cgatggcgag   1200

gaagactttg ttgggaacga tcctgcatca accatgcatc aacaaaaagc acagactttg   1260

aaggatccta ttgtttctat aggattttat tgcacaaagg caacggtgac tttcaaagta   1320

ggtcttttct cttgctgttt atatctctag caactttaat gcttaaattt ggattgttag   1380

tacaattcta gctttattca agtttgcttt gcattcagta gatgtgagat agagtctaac   1440

agttcttact tcataaaatt acatggctcc tccacttgaa atctttgaat tctgatccct   1500

tcctgtcttc ttagggcatt ctccacattt cttttttatt agcttcatgg atagtttttt   1560

gccctattga atcattcagt tggtgtacaa acatgcctta atattgtcat taaaaaagaa   1620

aggaacagc                                                           1629


<210>  1640
<211>  412
<212>  PRT
<213>  Homosapiens

<400>  1640

Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg 
1               5                   10                  15      


Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly 
            20                  25                  30          


Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu 
        35                  40                  45              


Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu 
    50                  55                  60                  


Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val 
65                  70                  75                  80  


Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile 
                85                  90                  95      


Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr 
            100                 105                 110         


Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala 
        115                 120                 125             


Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile 
    130                 135                 140                 


Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu 
145                 150                 155                 160 


Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala 
                165                 170                 175     


Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile 
            180                 185                 190         


Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys 
        195                 200                 205             


Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr 
    210                 215                 220                 


Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe 
225                 230                 235                 240 


Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His 
                245                 250                 255     


Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro 
            260                 265                 270         


Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu 
        275                 280                 285             


Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn 
    290                 295                 300                 


Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln 
                325                 330                 335     


Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe 
            340                 345                 350         


Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly 
        355                 360                 365             


Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys 
    370                 375                 380                 


Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr 
385                 390                 395                 400 


Phe Lys Val Gly Leu Phe Ser Cys Cys Leu Tyr Leu 
                405                 410         


<210>  1641
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1641
ggcgcggtac aggagcagca ctgccggcgg gggcgggtgc cagggacttg gaggtggagg     60

ggacgcggcg gtactctggc gtcttccgac ttcgactcct taccttaaaa gatgctggag    120

tcatatgtaa ctccaatttt aatgagctat gtgaatcgct acatcaagaa cttaaagccg    180

tcggatctac agctttcact atggggtgga gacgtggtac tcagcaagct cgagttaaag    240

ttggatgtgc tggaacagga actgaaatta ccattcactt ttttaagtgg acatattcat    300

gaattgagga ttcatgtacc atggacaaaa ctgggttcag aaccagtggt aattaccatc    360

aatactatgg aatgcatttt gaaacttaag gatgggatac aggatgacca tgaaagctgt    420

ggttctaatt ctaccaaccg tagtactgct gagagcacaa aatcatcaat caaaccgcgg    480

agaatgcagc aggctgctcc tacagatcct gacttaccac caggttatgt gcagagtctg    540

attagacgag ttgtaaataa tgtaaacatt gtgataaata atctcatact aaaatatgtt    600

gaagatgata tcgtcctttc cgtcaatatc acttctgcag aatgttatac agtaggtgaa    660

ttatgggatc gtgcattcat ggatatttct gcaactgatt tggtgctgag aaaggttatc    720

aatttttctg actgtacagt ttgtcttgat aaacggaatg ccagtggtaa aatagaattt    780

taccaggatc ctttattata caaatgttcc ttcagaactc gtcttcattt tacatatgaa    840

aacctaaatt ccaagatgcc atctgttatt aaaattcata ctttagtgga aagtttgaaa    900

ctttctatca cagatcaaca actgcctatg tttattcgta taatgcaact tggaattgct    960

ctttactatg gagaaatagg caattttaaa gaaggcgaaa tagaggacct tacttgtcat   1020

aataaagata tgctaggaaa cattacaggt tctgaagatg aaacaagaat agatatgcaa   1080

tatcctgctc agcataaagg tcaagagtta tattcacagc aagatgagga gcagccacag   1140

ggatgggtgt catgggcctg gtcctttgtg cctgcaattg tgagttatga cgatggcgag   1200

gaagactttg ttgggaacga tcctgcatca accatgcatc aacaaaaagc acagactttg   1260

aaggatccta ttgtttctat aggattttat tgcacaaagg caacggtgac tttcaaactc   1320

acagaaatgc aagttgagag tagttattac agtccacaga aagtaaaatc taaagaagta   1380

ttgtgttggg aacaagaagg aactacagtt gaggccctta tgatgggaga acctttcttt   1440

gattgccaga ttgggtttgt tggttgcaga gccatgtgcc ttaaaggaat tatgggtgtt   1500

aaagattttg aagagaatat gaatagaagt gaaactgaag cctgtttctt catttgtggt   1560

gacaatttga gtacgaaagg tttcacatac cttacaaatt cattgtttga ttaccgaagc   1620

ccagaaaata atggtactcg cgcagaattt atcttggatt caactcatca taaggagaca   1680

tacactgaga tagctggaat gcaacggttt ggggcttttt atatggatta cctgtataca   1740

atggagaaca ctagtggcaa aggttccaca aatcaacaag acttttcttc agggaaaagt   1800

gaagatttgg gaacagttca ggagaagtcc accaaaagcc ttgttatagg tcctcttgat   1860

tttcgtttgg atagcagtgc ggtgcatagg attttgaaaa tgattgtgtg tgccttggaa   1920

catgaatatg aaccatatag caggctaaaa tcagatatta aggatgaaaa tgaaacaata   1980

ctgaatcctg aagaggtggc tcttctggag gaatatattc ctactcgaca tacaagtgtt   2040

actctcctca aatgtacctg cacaatttcc atggctgaat tcaacttgct ggaccattta   2100

ctacctgtca ttatgggaga aaagaactca agtaacttca tgaatactac aaacttccag   2160

tctcttcggc ctttgccatc cattcgaata ttggtggata aaattaatct ggaacattca   2220

gtgccaatgt atgctgaaca gttggtgcat gtggtcagca gccttactca accttctgat   2280

aacctgcttc attattgtta tgtacactgc tatcttaaga tatttggttt ccaggcagga   2340

ctgacgtctt tggattgcag tggatcttac tgcttacctg taccagttat tccctctttc   2400

agcactgctc tttatgggaa acttctgaaa ctccccacat gctggaccaa aagatctcag   2460

attgctataa ctgaaggtat atttgaactt ccaaatctca caattcaagc tacaagagca   2520

cagacacttc tcttgcaagc aatatatcaa agttggtctc atcttggaaa tgtcagctct   2580

tccgcagtga ttgaagcttt gataaatgaa atcttcctaa gtataggtgt gaaatctaag   2640

aatcccctgc caactcttga gggctcaatc cagaatgttg aattgaagta ctgcagcaca   2700

tcattggtca aatgtgcctc tgggaccatg ggatcaataa aaatttgtgc caaagcccca   2760

gttgatagtg gaaaagagaa gttgattccc ttgcttcagg gtccttctga cactaaagac   2820

cttcatagca ccaagtggct caatgagagt agaaagccag agtctctctt agctccagat   2880

ttgatggcct tcacaatcca agttccacaa tatattgact actgccacaa ttccggtgct   2940

gtacttcttt gcagtataca aggactagca gttaatattg acccaatctt atatacgtgg   3000

ctcatctatc agcctcagaa acgaacaagt agacatatgc aacagcagcc tgtggtagct   3060

gttcctcttg ttatgccagt ttgtagaagg aaagaggatg aggtgtctat tggaagtgcc   3120

cccttggcaa agcagcaatc atatcaggcc tctgaatatg ccagcagccc tgtaaaaaca   3180

aaaacggtaa cagaatcccg cccattgtca gttcctgtta aagccatgtt gaatatatct   3240

gaaagctgta gaagtcctga agaaagaatg aaggaattta ttggaattgt ttggaatgca   3300

gtgaagcatc tcacactaca gcttgaagta caatcttgtt gtgtgtttat tccaaatgat   3360

agcctgcctt ccccaagtac aattgtatct ggtgacattc ctggaacagt aagaagttgg   3420

taccatggac aaaccagcat gccgggaaca cttgtcctct gtttgcctca aataaagatt   3480

attagtgctg ggcacaagta tatggaacct ctgcaggaga ttccatttgt tatcccacga   3540

cccatccttg aagaaggtga tgcttttcct tggacgatca gcttgcataa tttcagcata   3600

tatacccttc ttggaaaaca agtgacactt tgcctagtgg aacctatggg ttgcacctcc   3660

actctagctg tcacgtctca aaaactgctt gctacgggac ctgatacacg acattcattt   3720

gttgtctgtc tccatgttga cctagagtca ctagagataa aatgctctaa tccccaggtc   3780

cagctcttct atgaactaac tgatatcatg aataaggtct ggaacaagat tcagaagaga   3840

ggcaatctca acctatctcc aacctctcca gagaccatgg cagggcctgt tcctacttct   3900

ccagttagaa gcagtatagg cacagctcct ccagatacca gcacatgcag cccatctgct   3960

gacattggga ctactactga gggagattct atacaagcag gtgaggaatc accattctca   4020

gattctgtga ccttggaaca aactacaagt aatattggag gaaccagtgg acgtgttagt   4080

ttatggatgc agtgggtgct tcccaaaatt actataaagc tctttgctcc agatcctgaa   4140

aataaaggca cagaggtttg tatggtcagt gaactagaag atctcagtgc ttccatagat   4200

gtccaggatg tatataccaa agtgaaatgt aaaatagaga gtttcaatat tgatcactat   4260

agaagcagcc ttggggaaga gtgttggtct ttggggcaat gtggaggtgt cttcctttcc   4320

tgtactgaca agctgaacag acgcaccttg ttggttcgac ccatcagcaa gcaggaccct   4380

ttcagtaatt gctctggctt ctttccttct acaactacaa aacttctaga tggcactcat   4440

cagcagcatg gattcctctc tctgacatac acaaaagctg taacaaaaaa tgtccgccac   4500

aagttaacat caagaaatga gcgaagaagt tttcataagt tatctgaagg cctaatggat   4560

ggttctcctc attttcttca tgaaattctt ctttcagcac aagcttttga tattgttctt   4620

tattttcctt tacttaatgc cattgcaagt atatttcaag caaaactacc aaagacccaa   4680

aaagagaaaa gaaaatctcc tggtcagccc atgaggaccc atacactgac atcccgcaat   4740

ttacctttga tttatgtcaa cacaagtgta atcagaattt ttattccaaa aacagaagaa   4800

atgcagccaa ctgttgaagc taatcaggca gcaaaagaag acactgtggt tttgaagatt   4860

ggctctgttg ccatggctcc ccaggctgac aatccccttg gcagatctgt ccttaggaaa   4920

gatatttacc agagagcctt gaacttagga attcttcgag atcctggatc agaaatcgaa   4980

gacagacaat accaaataga tctgcagtcc atcaatattg gtactgcaca gtggcatcaa   5040

ctaaaaccag agaaggaaag tgtctcagga ggggtggtaa cagagactga aaggaattct   5100

caaaatccag cccttgagtg gaatatggcc agcagcatac ggcggcatca agaaaggaga   5160

gcaattttga cccccgtttt gacagatttt tctgtccgaa taactggagc acctgctgtc   5220

attttcacca aagtagtttc tccagaaaat ttgcatactg aggagatttt agtgtgtggc   5280

cattccttag aagtgaatat aaccacaaac ctggacttct tcctaagtgt ggctcaagtt   5340

caactcttac atcagttaat agtagcaaat atgactggac tggaaccatc aaacaaggct   5400

gcagagatct ctaaacaaga acagaaaaaa gtggatatat ttgatggagg catggctgaa   5460

acctcatctc gctacagtgg tgctcaggat agtggaattg gcagtgacag tgttaaaatc   5520

agaatagtgc aaatagagca gcacagtggt gccagtcagc atcgcattgc ccgtccctca   5580

cgccagtcat caattgtaaa aaatctaaat tttattccct ttgacatatt tattactgca   5640

agtagaatct cactaatgac ctattcctgt atggccttat ccaaatcgaa atcacaagaa   5700

cagaagaata atgaaaaaac agacaagagt tcattaaatc tcccagaagt tgattcagat   5760

gttgctaagc ccaaccaggc atgtatttcc acggtgacag cagaagatct cttaaggagc   5820

agcatttctt ttccttcagg gaaaaaaata ggggtcctct ctcttgaaag tcttcatgca   5880

tccacaaggt catctgctag acaagcactt ggtataacta ttgttcggca gcctggtcga   5940

agaggaactg gtgacttaca gctagagcct tttctgtact ttattgtgtc ccagccttcc   6000

ttgcttctga gttgtcacca cagaaagcag cgagtggaag tatccatttt tgatgctgtg   6060

cttaaagggg tggcctctga ttacaaatgt atagatcctg ggaagactct gcctgaagcc   6120

cttgattatt gcactgtttg gctacagaca gtgcctggag aaatagacag caaaagtggt   6180

attccacctt cctttataac actacagatt aaagactttc tgaatggacc agcggatgtc   6240

aatttggata tatcaaagcc tttgaaagca aacctgagtt tcaccaaact ggatcagata   6300

aacctttttt taaagaagat aaaaaatgca cacagtttgg cacatagtga agagacttca   6360

gccatgtcca acaccatggt gaataaggat gatcttccag tctccaaata ttaccgtgga   6420

aagttgtcta aacccaaaat tcatggtgat ggagtgcaaa agatttcagc tcaagaaaac   6480

atgtggagag ctgtttcctg ctttcaaaaa atttctgttc aaactactca gattgtgatc   6540

tccatggaaa ctgtacccca taccagcaaa ccatgcctgt tagcatctct ctcaaacctc   6600

aatggaagcc ttagtgtcaa ggcaacacaa aaagtacctg gcataattct tgggtcatca   6660

tttctactca gtataaacga ttttctcctt aaaacaagtc tcaaagaaag aagccgcatt   6720

ctgataggac catgttgtgc tactgccaat ctggaagcta agtggtgtaa acacagcggg   6780

aatccaggcc cagaacaatc cataccaaaa atatccattg acttaagagg aggtctacta   6840

caggtcttct ggggtcaaga acatttgaat tgtttagttc ttctacatga attactcaat   6900

ggatacctta atgaggaggg aaattttgaa gtacaagttt ctgaaccagt gcctcaaatg   6960

tcatctcctg tggaaaagaa tcagacattt aaaagtgaac aaagttcaga tgacctacgg   7020

acaggtctat ttcagtatgt acaggatgct gaatctttga aattgcctgg ggtctatgaa   7080

gtcttatttt ataatgaaac tgaagattgc ccagggatga tgttatggag atatccagaa   7140

cctagagtac tcacccttgt acgaataact cctgtacctt ttaacaccac agaggatcca   7200

gatattagca cagcagacct tggtgatgtg ctacaggttc cttgtagctt ggaatactgg   7260

gatgaactcc agaaggtttt tgttgcattt agagaattta atctgtctga aagcaaagtt   7320

tgtgaactgc agttgccgga tatcaatctc gtgaatgacc agaagaaatt agtatcttca   7380

gatctttgga gaattgtctt gaacagcagt caaaatggag ctgatgacca aagctctgca   7440

agtgagtctg gttctcaaag cacttgtgat ccacttgtga ctccaacagc cctggctgcc   7500

tgtaccagag ttgactcctg ctttacccca tggtttgtcc catccctttg cgtttctttc   7560

cagtttgctc acctggaatt ccatctttgt catcaccttg accaactagg cacagctgca   7620

ccacagtacc tacagccatt tgtttccgac agaaatatgc catctgaact agaatacatg   7680

attgtttcct tcagagaacc acacatgtat cttcgacagt ggaataatgg ttctgtctgt   7740

caggagatcc agttcttagc tcaagcagac tgtaaacttc tagagtgcag aaatgtcact   7800

atgcaaagtg tggtgaaacc cttcagcatc ttcgggcaga tggcagtttc cagcgatgta   7860

gtggaaaagc tgcttgactg caccgtgata gttgattctg tatttgtaaa ccttggacag   7920

catgtagtcc attcactaaa cactgcaata caagcttggc aacagaacaa atgccctgag   7980

gtagaggagt tggtcttcag ccattttgtg atctgtaatg acacacagga gacactgcgg   8040

tttggccagg tggatactga tgaaaatatt ctgctggcga gtctccacag tcaccagtac   8100

agctggcgct ctcacaaatc cccacagctg ttacacatct gtattgaagg ttggggcaac   8160

tggcgttggt cagagccttt cagtgtggac ca                                 8192


<210>  1642
<211>  4022
<212>  PRT
<213>  Homosapiens

<400>  1642

Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg 
1               5                   10                  15      


Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly 
            20                  25                  30          


Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu 
        35                  40                  45              


Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu 
    50                  55                  60                  


Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val 
65                  70                  75                  80  


Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile 
                85                  90                  95      


Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr 
            100                 105                 110         


Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala 
        115                 120                 125             


Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile 
    130                 135                 140                 


Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu 
145                 150                 155                 160 


Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala 
                165                 170                 175     


Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile 
            180                 185                 190         


Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys 
        195                 200                 205             


Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr 
    210                 215                 220                 


Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe 
225                 230                 235                 240 


Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His 
                245                 250                 255     


Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro 
            260                 265                 270         


Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu 
        275                 280                 285             


Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn 
    290                 295                 300                 


Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln 
                325                 330                 335     


Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe 
            340                 345                 350         


Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly 
        355                 360                 365             


Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys 
    370                 375                 380                 


Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr 
385                 390                 395                 400 


Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln 
                405                 410                 415     


Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr 
            420                 425                 430         


Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly 
        435                 440                 445             


Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys 
    450                 455                 460                 


Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe 
465                 470                 475                 480 


Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn 
                485                 490                 495     


Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu 
            500                 505                 510         


Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala 
        515                 520                 525             


Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Met 
    530                 535                 540                 


Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser 
545                 550                 555                 560 


Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser 
                565                 570                 575     


Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His 
            580                 585                 590         


Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro 
        595                 600                 605             


Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asp Glu Asn Glu Thr Ile Leu 
    610                 615                 620                 


Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His 
625                 630                 635                 640 


Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu 
                645                 650                 655     


Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn 
            660                 665                 670         


Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu 
        675                 680                 685             


Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val 
    690                 695                 700                 


Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln 
705                 710                 715                 720 


Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys 
                725                 730                 735     


Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser 
            740                 745                 750         


Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr 
        755                 760                 765             


Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile 
    770                 775                 780                 


Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala 
785                 790                 795                 800 


Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser 
                805                 810                 815     


His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn 
            820                 825                 830         


Glu Ile Phe Leu Ser Ile Gly Val Lys Ser Lys Asn Pro Leu Pro Thr 
        835                 840                 845             


Leu Glu Gly Ser Ile Gln Asn Val Glu Leu Lys Tyr Cys Ser Thr Ser 
    850                 855                 860                 


Leu Val Lys Cys Ala Ser Gly Thr Met Gly Ser Ile Lys Ile Cys Ala 
865                 870                 875                 880 


Lys Ala Pro Val Asp Ser Gly Lys Glu Lys Leu Ile Pro Leu Leu Gln 
                885                 890                 895     


Gly Pro Ser Asp Thr Lys Asp Leu His Ser Thr Lys Trp Leu Asn Glu 
            900                 905                 910         


Ser Arg Lys Pro Glu Ser Leu Leu Ala Pro Asp Leu Met Ala Phe Thr 
        915                 920                 925             


Ile Gln Val Pro Gln Tyr Ile Asp Tyr Cys His Asn Ser Gly Ala Val 
    930                 935                 940                 


Leu Leu Cys Ser Ile Gln Gly Leu Ala Val Asn Ile Asp Pro Ile Leu 
945                 950                 955                 960 


Tyr Thr Trp Leu Ile Tyr Gln Pro Gln Lys Arg Thr Ser Arg His Met 
                965                 970                 975     


Gln Gln Gln Pro Val Val Ala Val Pro Leu Val Met Pro Val Cys Arg 
            980                 985                 990         


Arg Lys Glu Asp Glu Val Ser Ile  Gly Ser Ala Pro Leu  Ala Lys Gln 
        995                 1000                 1005             


Gln Ser  Tyr Gln Ala Ser Glu  Tyr Ala Ser Ser Pro  Val Lys Thr 
    1010                 1015                 1020             


Lys Thr  Val Thr Glu Ser Arg  Pro Leu Ser Val Pro  Val Lys Ala 
    1025                 1030                 1035             


Met Leu  Asn Ile Ser Glu Ser  Cys Arg Ser Pro Glu  Glu Arg Met 
    1040                 1045                 1050             


Lys Glu  Phe Ile Gly Ile Val  Trp Asn Ala Val Lys  His Leu Thr 
    1055                 1060                 1065             


Leu Gln  Leu Glu Val Gln Ser  Cys Cys Val Phe Ile  Pro Asn Asp 
    1070                 1075                 1080             


Ser Leu  Pro Ser Pro Ser Thr  Ile Val Ser Gly Asp  Ile Pro Gly 
    1085                 1090                 1095             


Thr Val  Arg Ser Trp Tyr His  Gly Gln Thr Ser Met  Pro Gly Thr 
    1100                 1105                 1110             


Leu Val  Leu Cys Leu Pro Gln  Ile Lys Ile Ile Ser  Ala Gly His 
    1115                 1120                 1125             


Lys Tyr  Met Glu Pro Leu Gln  Glu Ile Pro Phe Val  Ile Pro Arg 
    1130                 1135                 1140             


Pro Ile  Leu Glu Glu Gly Asp  Ala Phe Pro Trp Thr  Ile Ser Leu 
    1145                 1150                 1155             


His Asn  Phe Ser Ile Tyr Thr  Leu Leu Gly Lys Gln  Val Thr Leu 
    1160                 1165                 1170             


Cys Leu  Val Glu Pro Met Gly  Cys Thr Ser Thr Leu  Ala Val Thr 
    1175                 1180                 1185             


Ser Gln  Lys Leu Leu Ala Thr  Gly Pro Asp Thr Arg  His Ser Phe 
    1190                 1195                 1200             


Val Val  Cys Leu His Val Asp  Leu Glu Ser Leu Glu  Ile Lys Cys 
    1205                 1210                 1215             


Ser Asn  Pro Gln Val Gln Leu  Phe Tyr Glu Leu Thr  Asp Ile Met 
    1220                 1225                 1230             


Asn Lys  Val Trp Asn Lys Ile  Gln Lys Arg Gly Asn  Leu Asn Leu 
    1235                 1240                 1245             


Ser Pro  Thr Ser Pro Glu Thr  Met Ala Gly Pro Val  Pro Thr Ser 
    1250                 1255                 1260             


Pro Val  Arg Ser Ser Ile Gly  Thr Ala Pro Pro Asp  Thr Ser Thr 
    1265                 1270                 1275             


Cys Ser  Pro Ser Ala Asp Ile  Gly Thr Thr Thr Glu  Gly Asp Ser 
    1280                 1285                 1290             


Ile Gln  Ala Gly Glu Glu Ser  Pro Phe Ser Asp Ser  Val Thr Leu 
    1295                 1300                 1305             


Glu Gln  Thr Thr Ser Asn Ile  Gly Gly Thr Ser Gly  Arg Val Ser 
    1310                 1315                 1320             


Leu Trp  Met Gln Trp Val Leu  Pro Lys Ile Thr Ile  Lys Leu Phe 
    1325                 1330                 1335             


Ala Pro  Asp Pro Glu Asn Lys  Gly Thr Glu Val Cys  Met Val Ser 
    1340                 1345                 1350             


Glu Leu  Glu Asp Leu Ser Ala  Ser Ile Asp Val Gln  Asp Val Tyr 
    1355                 1360                 1365             


Thr Lys  Val Lys Cys Lys Ile  Glu Ser Phe Asn Ile  Asp His Tyr 
    1370                 1375                 1380             


Arg Ser  Ser Leu Gly Glu Glu  Cys Trp Ser Leu Gly  Gln Cys Gly 
    1385                 1390                 1395             


Gly Val  Phe Leu Ser Cys Thr  Asp Lys Leu Asn Arg  Arg Thr Leu 
    1400                 1405                 1410             


Leu Val  Arg Pro Ile Ser Lys  Gln Asp Pro Phe Ser  Asn Cys Ser 
    1415                 1420                 1425             


Gly Phe  Phe Pro Ser Thr Thr  Thr Lys Leu Leu Asp  Gly Thr His 
    1430                 1435                 1440             


Gln Gln  His Gly Phe Leu Ser  Leu Thr Tyr Thr Lys  Ala Val Thr 
    1445                 1450                 1455             


Lys Asn  Val Arg His Lys Leu  Thr Ser Arg Asn Glu  Arg Arg Ser 
    1460                 1465                 1470             


Phe His  Lys Leu Ser Glu Gly  Leu Met Asp Gly Ser  Pro His Phe 
    1475                 1480                 1485             


Leu His  Glu Ile Leu Leu Ser  Ala Gln Ala Phe Asp  Ile Val Leu 
    1490                 1495                 1500             


Tyr Phe  Pro Leu Leu Asn Ala  Ile Ala Ser Ile Phe  Gln Ala Lys 
    1505                 1510                 1515             


Leu Pro  Lys Thr Gln Lys Glu  Lys Arg Lys Ser Pro  Gly Gln Pro 
    1520                 1525                 1530             


Met Arg  Thr His Thr Leu Thr  Ser Arg Asn Leu Pro  Leu Ile Tyr 
    1535                 1540                 1545             


Val Asn  Thr Ser Val Ile Arg  Ile Phe Ile Pro Lys  Thr Glu Glu 
    1550                 1555                 1560             


Met Gln  Pro Thr Val Glu Ala  Asn Gln Ala Ala Lys  Glu Asp Thr 
    1565                 1570                 1575             


Val Val  Leu Lys Ile Gly Ser  Val Ala Met Ala Pro  Gln Ala Asp 
    1580                 1585                 1590             


Asn Pro  Leu Gly Arg Ser Val  Leu Arg Lys Asp Ile  Tyr Gln Arg 
    1595                 1600                 1605             


Ala Leu  Asn Leu Gly Ile Leu  Arg Asp Pro Gly Ser  Glu Ile Glu 
    1610                 1615                 1620             


Asp Arg  Gln Tyr Gln Ile Asp  Leu Gln Ser Ile Asn  Ile Gly Thr 
    1625                 1630                 1635             


Ala Gln  Trp His Gln Leu Lys  Pro Glu Lys Glu Ser  Val Ser Gly 
    1640                 1645                 1650             


Gly Val  Val Thr Glu Thr Glu  Arg Asn Ser Gln Asn  Pro Ala Leu 
    1655                 1660                 1665             


Glu Trp  Asn Met Ala Ser Ser  Ile Arg Arg His Gln  Glu Arg Arg 
    1670                 1675                 1680             


Ala Ile  Leu Thr Pro Val Leu  Thr Asp Phe Ser Val  Arg Ile Thr 
    1685                 1690                 1695             


Gly Ala  Pro Ala Val Ile Phe  Thr Lys Val Val Ser  Pro Glu Asn 
    1700                 1705                 1710             


Leu His  Thr Glu Glu Ile Leu  Val Cys Gly His Ser  Leu Glu Val 
    1715                 1720                 1725             


Asn Ile  Thr Thr Asn Leu Asp  Phe Phe Leu Ser Val  Ala Gln Val 
    1730                 1735                 1740             


Gln Leu  Leu His Gln Leu Ile  Val Ala Asn Met Thr  Gly Leu Glu 
    1745                 1750                 1755             


Pro Ser  Asn Lys Ala Ala Glu  Ile Ser Lys Gln Glu  Gln Lys Lys 
    1760                 1765                 1770             


Val Asp  Ile Phe Asp Gly Gly  Met Ala Glu Thr Ser  Ser Arg Tyr 
    1775                 1780                 1785             


Ser Gly  Ala Gln Asp Ser Gly  Ile Gly Ser Asp Ser  Val Lys Ile 
    1790                 1795                 1800             


Arg Ile  Val Gln Ile Glu Gln  His Ser Gly Ala Ser  Gln His Arg 
    1805                 1810                 1815             


Ile Ala  Arg Pro Ser Arg Gln  Ser Ser Ile Val Lys  Asn Leu Asn 
    1820                 1825                 1830             


Phe Ile  Pro Phe Asp Ile Phe  Ile Thr Ala Ser Arg  Ile Ser Leu 
    1835                 1840                 1845             


Met Thr  Tyr Ser Cys Met Ala  Leu Ser Lys Ser Lys  Ser Gln Glu 
    1850                 1855                 1860             


Gln Lys  Asn Asn Glu Lys Thr  Asp Lys Ser Ser Leu  Asn Leu Pro 
    1865                 1870                 1875             


Glu Val  Asp Ser Asp Val Ala  Lys Pro Asn Gln Ala  Cys Ile Ser 
    1880                 1885                 1890             


Thr Val  Thr Ala Glu Asp Leu  Leu Arg Ser Ser Ile  Ser Phe Pro 
    1895                 1900                 1905             


Ser Gly  Lys Lys Ile Gly Val  Leu Ser Leu Glu Ser  Leu His Ala 
    1910                 1915                 1920             


Ser Thr  Arg Ser Ser Ala Arg  Gln Ala Leu Gly Ile  Thr Ile Val 
    1925                 1930                 1935             


Arg Gln  Pro Gly Arg Arg Gly  Thr Gly Asp Leu Gln  Leu Glu Pro 
    1940                 1945                 1950             


Phe Leu  Tyr Phe Ile Val Ser  Gln Pro Ser Leu Leu  Leu Ser Cys 
    1955                 1960                 1965             


His His  Arg Lys Gln Arg Val  Glu Val Ser Ile Phe  Asp Ala Val 
    1970                 1975                 1980             


Leu Lys  Gly Val Ala Ser Asp  Tyr Lys Cys Ile Asp  Pro Gly Lys 
    1985                 1990                 1995             


Thr Leu  Pro Glu Ala Leu Asp  Tyr Cys Thr Val Trp  Leu Gln Thr 
    2000                 2005                 2010             


Val Pro  Gly Glu Ile Asp Ser  Lys Ser Gly Ile Pro  Pro Ser Phe 
    2015                 2020                 2025             


Ile Thr  Leu Gln Ile Lys Asp  Phe Leu Asn Gly Pro  Ala Asp Val 
    2030                 2035                 2040             


Asn Leu  Asp Ile Ser Lys Pro  Leu Lys Ala Asn Leu  Ser Phe Thr 
    2045                 2050                 2055             


Lys Leu  Asp Gln Ile Asn Leu  Phe Leu Lys Lys Ile  Lys Asn Ala 
    2060                 2065                 2070             


His Ser  Leu Ala His Ser Glu  Glu Thr Ser Ala Met  Ser Asn Thr 
    2075                 2080                 2085             


Met Val  Asn Lys Asp Asp Leu  Pro Val Ser Lys Tyr  Tyr Arg Gly 
    2090                 2095                 2100             


Lys Leu  Ser Lys Pro Lys Ile  His Gly Asp Gly Val  Gln Lys Ile 
    2105                 2110                 2115             


Ser Ala  Gln Glu Asn Met Trp  Arg Ala Val Ser Cys  Phe Gln Lys 
    2120                 2125                 2130             


Ile Ser  Val Gln Thr Thr Gln  Ile Val Ile Ser Met  Glu Thr Val 
    2135                 2140                 2145             


Pro His  Thr Ser Lys Pro Cys  Leu Leu Ala Ser Leu  Ser Asn Leu 
    2150                 2155                 2160             


Asn Gly  Ser Leu Ser Val Lys  Ala Thr Gln Lys Val  Pro Gly Ile 
    2165                 2170                 2175             


Ile Leu  Gly Ser Ser Phe Leu  Leu Ser Ile Asn Asp  Phe Leu Leu 
    2180                 2185                 2190             


Lys Thr  Ser Leu Lys Glu Arg  Ser Arg Ile Leu Ile  Gly Pro Cys 
    2195                 2200                 2205             


Cys Ala  Thr Ala Asn Leu Glu  Ala Lys Trp Cys Lys  His Ser Gly 
    2210                 2215                 2220             


Asn Pro  Gly Pro Glu Gln Ser  Ile Pro Lys Ile Ser  Ile Asp Leu 
    2225                 2230                 2235             


Arg Gly  Gly Leu Leu Gln Val  Phe Trp Gly Gln Glu  His Leu Asn 
    2240                 2245                 2250             


Cys Leu  Val Leu Leu His Glu  Leu Leu Asn Gly Tyr  Leu Asn Glu 
    2255                 2260                 2265             


Glu Gly  Asn Phe Glu Val Gln  Val Ser Glu Pro Val  Pro Gln Met 
    2270                 2275                 2280             


Ser Ser  Pro Val Glu Lys Asn  Gln Thr Phe Lys Ser  Glu Gln Ser 
    2285                 2290                 2295             


Ser Asp  Asp Leu Arg Thr Gly  Leu Phe Gln Tyr Val  Gln Asp Ala 
    2300                 2305                 2310             


Glu Ser  Leu Lys Leu Pro Gly  Val Tyr Glu Val Leu  Phe Tyr Asn 
    2315                 2320                 2325             


Glu Thr  Glu Asp Cys Pro Gly  Met Met Leu Trp Arg  Tyr Pro Glu 
    2330                 2335                 2340             


Pro Arg  Val Leu Thr Leu Val  Arg Ile Thr Pro Val  Pro Phe Asn 
    2345                 2350                 2355             


Thr Thr  Glu Asp Pro Asp Ile  Ser Thr Ala Asp Leu  Gly Asp Val 
    2360                 2365                 2370             


Leu Gln  Val Pro Cys Ser Leu  Glu Tyr Trp Asp Glu  Leu Gln Lys 
    2375                 2380                 2385             


Val Phe  Val Ala Phe Arg Glu  Phe Asn Leu Ser Glu  Ser Lys Val 
    2390                 2395                 2400             


Cys Glu  Leu Gln Leu Pro Asp  Ile Asn Leu Val Asn  Asp Gln Lys 
    2405                 2410                 2415             


Lys Leu  Val Ser Ser Asp Leu  Trp Arg Ile Val Leu  Asn Ser Ser 
    2420                 2425                 2430             


Gln Asn  Gly Ala Asp Asp Gln  Ser Ser Ala Ser Glu  Ser Gly Ser 
    2435                 2440                 2445             


Gln Ser  Thr Cys Asp Pro Leu  Val Thr Pro Thr Ala  Leu Ala Ala 
    2450                 2455                 2460             


Cys Thr  Arg Val Asp Ser Cys  Phe Thr Pro Trp Phe  Val Pro Ser 
    2465                 2470                 2475             


Leu Cys  Val Ser Phe Gln Phe  Ala His Leu Glu Phe  His Leu Cys 
    2480                 2485                 2490             


His His  Leu Asp Gln Leu Gly  Thr Ala Ala Pro Gln  Tyr Leu Gln 
    2495                 2500                 2505             


Pro Phe  Val Ser Asp Arg Asn  Met Pro Ser Glu Leu  Glu Tyr Met 
    2510                 2515                 2520             


Ile Val  Ser Phe Arg Glu Pro  His Met Tyr Leu Arg  Gln Trp Asn 
    2525                 2530                 2535             


Asn Gly  Ser Val Cys Gln Glu  Ile Gln Phe Leu Ala  Gln Ala Asp 
    2540                 2545                 2550             


Cys Lys  Leu Leu Glu Cys Arg  Asn Val Thr Met Gln  Ser Val Val 
    2555                 2560                 2565             


Lys Pro  Phe Ser Ile Phe Gly  Gln Met Ala Val Ser  Ser Asp Val 
    2570                 2575                 2580             


Val Glu  Lys Leu Leu Asp Cys  Thr Val Ile Val Asp  Ser Val Phe 
    2585                 2590                 2595             


Val Asn  Leu Gly Gln His Val  Val His Ser Leu Asn  Thr Ala Ile 
    2600                 2605                 2610             


Gln Ala  Trp Gln Gln Asn Lys  Cys Pro Glu Val Glu  Glu Leu Val 
    2615                 2620                 2625             


Phe Ser  His Phe Val Ile Cys  Asn Asp Thr Gln Glu  Thr Leu Arg 
    2630                 2635                 2640             


Phe Gly  Gln Val Asp Thr Asp  Glu Asn Ile Leu Leu  Ala Ser Leu 
    2645                 2650                 2655             


His Ser  His Gln Tyr Ser Trp  Arg Ser His Lys Ser  Pro Gln Leu 
    2660                 2665                 2670             


Leu His  Ile Cys Ile Glu Gly  Trp Gly Asn Trp Arg  Trp Ser Glu 
    2675                 2680                 2685             


Pro Phe  Ser Val Asp His Ala  Gly Thr Phe Ile Arg  Thr Ile Gln 
    2690                 2695                 2700             


Tyr Arg  Gly Arg Thr Ala Ser  Leu Ile Ile Lys Val  Gln Gln Leu 
    2705                 2710                 2715             


Asn Gly  Val Gln Lys Gln Ile  Ile Ile Cys Gly Arg  Gln Ile Ile 
    2720                 2725                 2730             


Cys Ser  Tyr Leu Ser Gln Ser  Ile Glu Leu Lys Val  Val Gln His 
    2735                 2740                 2745             


Tyr Ile  Gly Gln Asp Gly Gln  Ala Val Val Arg Glu  His Phe Asp 
    2750                 2755                 2760             


Cys Leu  Thr Ala Lys Gln Lys  Leu Pro Ser Tyr Ile  Leu Glu Asn 
    2765                 2770                 2775             


Asn Glu  Leu Thr Glu Leu Cys  Val Lys Ala Lys Gly  Asp Glu Asp 
    2780                 2785                 2790             


Trp Ser  Arg Asp Val Cys Leu  Glu Ser Lys Ala Pro  Glu Tyr Ser 
    2795                 2800                 2805             


Ile Val  Ile Gln Val Pro Ser  Ser Asn Ser Ser Ile  Ile Tyr Val 
    2810                 2815                 2820             


Trp Cys  Thr Val Leu Thr Leu  Glu Pro Asn Ser Gln  Val Gln Gln 
    2825                 2830                 2835             


Arg Met  Ile Val Phe Ser Pro  Leu Phe Ile Met Arg  Ser His Leu 
    2840                 2845                 2850             


Pro Asp  Pro Ile Ile Ile His  Leu Glu Lys Arg Ser  Leu Gly Leu 
    2855                 2860                 2865             


Ser Glu  Thr Gln Ile Ile Pro  Gly Lys Gly Gln Glu  Lys Pro Leu 
    2870                 2875                 2880             


Gln Asn  Ile Glu Pro Asp Leu  Val His His Leu Thr  Phe Gln Ala 
    2885                 2890                 2895             


Arg Glu  Glu Tyr Asp Pro Ser  Asp Cys Ala Val Pro  Ile Ser Thr 
    2900                 2905                 2910             


Ser Leu  Ile Lys Gln Ile Ala  Thr Lys Val His Pro  Gly Gly Thr 
    2915                 2920                 2925             


Val Asn  Gln Ile Leu Asp Glu  Phe Tyr Gly Pro Glu  Lys Ser Leu 
    2930                 2935                 2940             


Gln Pro  Ile Trp Pro Tyr Asn  Lys Lys Asp Ser Asp  Arg Asn Glu 
    2945                 2950                 2955             


Gln Leu  Ser Gln Trp Asp Ser  Pro Met Arg Val Lys  Leu Ser Ile 
    2960                 2965                 2970             


Trp Lys  Pro Tyr Val Arg Thr  Leu Leu Ile Glu Leu  Leu Pro Trp 
    2975                 2980                 2985             


Ala Leu  Leu Ile Asn Glu Ser  Lys Trp Asp Leu Trp  Leu Phe Glu 
    2990                 2995                 3000             


Gly Glu  Lys Ile Val Leu Gln  Val Pro Ala Gly Lys  Ile Ile Ile 
    3005                 3010                 3015             


Pro Pro  Asn Phe Gln Glu Ala  Phe Gln Ile Gly Ile  Tyr Trp Ala 
    3020                 3025                 3030             


Asn Thr  Asn Thr Val His Lys  Ser Val Ala Ile Lys  Leu Val His 
    3035                 3040                 3045             


Asn Leu  Thr Ser Pro Lys Trp  Lys Asp Gly Gly Asn  Gly Glu Val 
    3050                 3055                 3060             


Val Thr  Leu Asp Glu Glu Ala  Phe Val Asp Thr Glu  Ile Arg Leu 
    3065                 3070                 3075             


Gly Ala  Phe Pro Gly His Gln  Lys Leu Cys Gln Phe  Cys Ile Ser 
    3080                 3085                 3090             


Ser Met  Val Gln Gln Gly Ile  Gln Ile Ile Gln Ile  Glu Asp Lys 
    3095                 3100                 3105             


Thr Thr  Ile Ile Asn Asn Thr  Pro Tyr Gln Ile Phe  Tyr Lys Pro 
    3110                 3115                 3120             


Gln Leu  Ser Val Cys Asn Pro  His Ser Gly Lys Glu  Tyr Phe Arg 
    3125                 3130                 3135             


Val Pro  Asp Ser Ala Thr Phe  Ser Ile Cys Pro Gly  Gly Glu Gln 
    3140                 3145                 3150             


Pro Ala  Met Lys Ser Ser Ser  Leu Pro Cys Trp Asp  Leu Met Pro 
    3155                 3160                 3165             


Asp Ile  Ser Gln Ser Val Leu  Asp Ala Ser Leu Leu  Gln Lys Gln 
    3170                 3175                 3180             


Ile Met  Leu Gly Phe Ser Pro  Ala Pro Gly Ala Asp  Ser Ser Gln 
    3185                 3190                 3195             


Cys Trp  Ser Leu Pro Ala Ile  Val Arg Pro Glu Phe  Pro Arg Gln 
    3200                 3205                 3210             


Ser Val  Ala Val Pro Leu Gly  Asn Phe Arg Glu Asn  Gly Phe Cys 
    3215                 3220                 3225             


Thr Arg  Ala Ile Val Leu Thr  Tyr Gln Glu His Leu  Gly Val Thr 
    3230                 3235                 3240             


Tyr Leu  Thr Leu Ser Glu Asp  Pro Ser Pro Arg Val  Ile Ile His 
    3245                 3250                 3255             


Asn Arg  Cys Pro Val Lys Met  Leu Ile Lys Glu Asn  Ile Lys Asp 
    3260                 3265                 3270             


Ile Pro  Lys Phe Glu Val Tyr  Cys Lys Lys Ile Pro  Ser Glu Cys 
    3275                 3280                 3285             


Ser Ile  His His Glu Leu Tyr  His Gln Ile Ser Ser  Tyr Pro Asp 
    3290                 3295                 3300             


Cys Lys  Thr Lys Asp Leu Leu  Pro Ser Leu Leu Leu  Arg Val Glu 
    3305                 3310                 3315             


Pro Leu  Asp Glu Val Thr Thr  Glu Trp Ser Asp Ala  Ile Asp Ile 
    3320                 3325                 3330             


Asn Ser  Gln Gly Thr Gln Val  Val Phe Leu Thr Gly  Phe Gly Tyr 
    3335                 3340                 3345             


Val Tyr  Val Asp Val Val His  Gln Cys Gly Thr Val  Phe Ile Thr 
    3350                 3355                 3360             


Val Ala  Pro Glu Gly Lys Ala  Gly Pro Ile Leu Thr  Asn Thr Asn 
    3365                 3370                 3375             


Arg Ala  Pro Glu Lys Ile Val  Thr Phe Lys Met Phe  Ile Thr Gln 
    3380                 3385                 3390             


Leu Ser  Leu Ala Val Phe Asp  Asp Leu Thr His His  Lys Ala Ser 
    3395                 3400                 3405             


Ala Glu  Leu Leu Arg Leu Thr  Leu Asp Asn Ile Phe  Leu Cys Val 
    3410                 3415                 3420             


Ala Pro  Gly Ala Gly Pro Leu  Pro Gly Glu Glu Pro  Val Ala Ala 
    3425                 3430                 3435             


Leu Phe  Glu Leu Tyr Cys Val  Glu Ile Cys Cys Gly  Asp Leu Gln 
    3440                 3445                 3450             


Leu Asp  Asn Gln Leu Tyr Asn  Lys Ser Asn Phe His  Phe Ala Val 
    3455                 3460                 3465             


Leu Val  Cys Gln Gly Glu Lys  Ala Glu Pro Ile Gln  Cys Ser Lys 
    3470                 3475                 3480             


Met Gln  Ser Leu Leu Ile Ser  Asn Lys Glu Leu Glu  Glu Tyr Lys 
    3485                 3490                 3495             


Glu Lys  Cys Phe Ile Lys Leu  Cys Ile Thr Leu Asn  Glu Gly Lys 
    3500                 3505                 3510             


Ser Ile  Leu Cys Asp Ile Asn  Glu Phe Ser Phe Glu  Leu Lys Pro 
    3515                 3520                 3525             


Ala Arg  Leu Tyr Val Glu Asp  Thr Phe Val Tyr Tyr  Ile Lys Thr 
    3530                 3535                 3540             


Leu Phe  Asp Thr Tyr Leu Pro  Asn Ser Arg Leu Ala  Gly His Ser 
    3545                 3550                 3555             


Thr His  Leu Ser Gly Gly Lys  Gln Val Leu Pro Met  Gln Val Thr 
    3560                 3565                 3570             


Gln His  Ala Arg Ala Leu Val  Asn Pro Val Lys Leu  Arg Lys Leu 
    3575                 3580                 3585             


Val Ile  Gln Pro Val Asn Leu  Leu Val Ser Ile His  Ala Ser Leu 
    3590                 3595                 3600             


Lys Leu  Tyr Ile Ala Ser Asp  His Thr Pro Leu Ser  Phe Ser Val 
    3605                 3610                 3615             


Phe Glu  Arg Gly Pro Ile Phe  Thr Thr Ala Arg Gln  Leu Val His 
    3620                 3625                 3630             


Ala Leu  Ala Met His Tyr Ala  Ala Gly Ala Leu Phe  Arg Ala Gly 
    3635                 3640                 3645             


Trp Val  Val Gly Ser Leu Asp  Ile Leu Gly Ser Pro  Ala Ser Leu 
    3650                 3655                 3660             


Val Arg  Ser Ile Gly Asn Gly  Val Ala Asp Phe Phe  Arg Leu Pro 
    3665                 3670                 3675             


Tyr Glu  Gly Leu Thr Arg Gly  Pro Gly Ala Phe Val  Ser Gly Val 
    3680                 3685                 3690             


Ser Arg  Gly Thr Thr Ser Phe  Val Lys His Ile Ser  Lys Gly Thr 
    3695                 3700                 3705             


Leu Thr  Ser Ile Thr Asn Leu  Ala Thr Ser Leu Ala  Arg Asn Met 
    3710                 3715                 3720             


Asp Arg  Leu Ser Leu Asp Glu  Glu His Tyr Asn Arg  Gln Glu Glu 
    3725                 3730                 3735             


Trp Arg  Arg Gln Leu Pro Glu  Ser Leu Gly Glu Gly  Leu Arg Gln 
    3740                 3745                 3750             


Gly Leu  Ser Arg Leu Gly Ile  Ser Leu Leu Gly Ala  Ile Ala Gly 
    3755                 3760                 3765             


Ile Val  Asp Gln Pro Met Gln  Asn Phe Gln Lys Thr  Ser Glu Ala 
    3770                 3775                 3780             


Gln Ala  Ser Ala Gly His Lys  Ala Lys Gly Val Ile  Ser Gly Val 
    3785                 3790                 3795             


Gly Lys  Gly Ile Met Gly Val  Phe Thr Lys Pro Ile  Gly Gly Ala 
    3800                 3805                 3810             


Ala Glu  Leu Val Ser Gln Thr  Gly Tyr Gly Ile Leu  His Gly Ala 
    3815                 3820                 3825             


Gly Leu  Ser Gln Leu Pro Lys  Gln Arg His Gln Pro  Ser Asp Leu 
    3830                 3835                 3840             


His Ala  Asp Gln Ala Pro Asn  Ser His Val Lys Tyr  Val Trp Lys 
    3845                 3850                 3855             


Met Leu  Gln Ser Leu Gly Arg  Pro Glu Val His Met  Ala Leu Asp 
    3860                 3865                 3870             


Val Val  Leu Val Arg Gly Ser  Gly Gln Glu His Glu  Gly Cys Leu 
    3875                 3880                 3885             


Leu Leu  Thr Ser Glu Val Leu  Phe Val Val Ser Val  Ser Glu Asp 
    3890                 3895                 3900             


Thr Gln  Gln Gln Ala Phe Pro  Val Thr Glu Ile Asp  Cys Ala Gln 
    3905                 3910                 3915             


Asp Ser  Lys Gln Asn Asn Leu  Leu Thr Val Gln Leu  Lys Gln Pro 
    3920                 3925                 3930             


Arg Val  Ala Cys Asp Val Glu  Val Asp Gly Val Arg  Glu Arg Leu 
    3935                 3940                 3945             


Ser Glu  Gln Gln Tyr Asn Arg  Leu Val Asp Tyr Ile  Thr Lys Thr 
    3950                 3955                 3960             


Ser Cys  His Leu Ala Pro Ser  Cys Ser Ser Met Gln  Ile Pro Cys 
    3965                 3970                 3975             


Pro Val  Val Ala Ala Glu Pro  Pro Pro Ser Thr Val  Lys Thr Tyr 
    3980                 3985                 3990             


His Tyr  Leu Val Asp Pro His  Phe Ala Gln Val Phe  Leu Ser Lys 
    3995                 4000                 4005             


Phe Thr  Met Val Lys Asn Lys  Ala Leu Arg Lys Gly  Phe Pro 
    4010                 4015                 4020         


<210>  1643
<211>  5654
<212>  DNA
<213>  Homosapiens

<400>  1643
ggcgcggtac aggagcagca ctgccggcgg gggcgggtgc cagggacttg gaggtggagg     60

ggacgcggcg gtactctggc gtcttccgac ttcgactcct taccttaaaa gatgctggag    120

tcatatgtaa ctccaatttt aatgagctat gtgaatcgct acatcaagaa cttaaagccg    180

tcggatctac agctttcact atggggtgga gacgtggtac tcagcaagct cgagttaaag    240

ttggatgtgc tggaacagga actgaaatta ccattcactt ttttaagtgg acatattcat    300

gaattgagga ttcatgtacc atggacaaaa ctgggttcag aaccagtggt aattaccatc    360

aatactatgg aatgcatttt gaaacttaag gatgggatac aggatgacca tgaaagctgt    420

ggttctaatt ctaccaaccg tagtactgct gagagcacaa aatcatcaat caaaccgcgg    480

agaatgcagc aggctgctcc tacagatcct gacttaccac caggttatgt gcagagtctg    540

attagacgag ttgtaaataa tgtaaacatt gtgataaata atctcatact aaaatatgtt    600

gaagatgata tcgtcctttc cgtcaatatc acttctgcag aatgttatac agtaggtgaa    660

ttatgggatc gtgcattcat ggatatttct gcaactgatt tggtgctgag aaaggttatc    720

aatttttctg actgtacagt ttgtcttgat aaacggaatg ccagtggtaa aatagaattt    780

taccaggatc ctttattata caaatgttcc ttcagaactc gtcttcattt tacatatgaa    840

aacctaaatt ccaagatgcc atctgttatt aaaattcata ctttagtgga aagtttgaaa    900

ctttctatca cagatcaaca actgcctatg tttattcgta taatgcaact tggaattgct    960

ctttactatg gagaaatagg caattttaaa gaaggcgaaa tagaggacct tacttgtcat   1020

aataaagata tgctaggaaa cattacaggt tctgaagatg aaacaagaat agatatgcaa   1080

tatcctgctc agcataaagg tcaagagtta tattcacagc aagatgagga gcagccacag   1140

ggatgggtgt catgggcctg gtcctttgtg cctgcaattg tgagttatga cgatggcgag   1200

gaagactttg ttgggaacga tcctgcatca accatgcatc aacaaaaagc acagactttg   1260

aaggatccta ttgtttctat aggattttat tgcacaaagg caacggtgac tttcaaactc   1320

acagaaatgc aagttgagag tagttattac agtccacaga aagtaaaatc taaagaagta   1380

ttgtgttggg aacaagaagg aactacagtt gaggccctta tgatgggaga acctttcttt   1440

gattgccaga ttgggtttgt tggttgcaga gccatgtgcc ttaaaggaat tatgggtgtt   1500

aaagattttg aagagaatat gaatagaagt gaaactgaag cctgtttctt catttgtggt   1560

gacaatttga gtacgaaagg tttcacatac cttacaaatt cattgtttga ttaccgaagc   1620

ccagaaaata atggtactcg cgcagaattt atcttggatt caactcatca taaggagaca   1680

tacactgaga tagctggaat gcaacggttt ggggcttttt atatggatta cctgtataca   1740

atggagaaca ctagtggcaa aggttccaca aatcaacaag acttttcttc agggaaaagt   1800

gaagatttgg gaacagttca ggagaagtcc accaaaagcc ttgttatagg tcctcttgat   1860

tttcgtttgg atagcagtgc ggtgcatagg attttgaaaa tgattgtgtg tgccttggaa   1920

catgaatatg aaccatatag caggctaaaa tcagatatta aggatgaaaa tgaaacaata   1980

ctgaatcctg aagaggtggc tcttctggag gaatatattc ctactcgaca tacaagtgtt   2040

actctcctca aatgtacctg cacaatttcc atggctgaat tcaacttgct ggaccattta   2100

ctacctgtca ttatgggaga aaagaactca agtaacttca tgaatactac aaacttccag   2160

tctcttcggc ctttgccatc cattcgaata ttggtggata aaattaatct ggaacattca   2220

gtgccaatgt atgctgaaca gttggtgcat gtggtcagca gccttactca accttctgat   2280

aacctgcttc attattgtta tgtacactgc tatcttaaga tatttggttt ccaggcagga   2340

ctgacgtctt tggattgcag tggatcttac tgcttacctg taccagttat tccctctttc   2400

agcactgctc tttatgggaa acttctgaaa ctccccacat gctggaccaa aagatctcag   2460

attgctataa ctgaaggtat atttgaactt ccaaatctca caattcaagc tacaagagca   2520

cagacacttc tcttgcaagc aatatatcaa agttggtctc atcttggaaa tgtcagctct   2580

tccgcagtga ttgaagcttt gataaatgaa atcttcctaa gtataggtgt gaaatctaag   2640

aatcccctgc caactcttga gggctcaatc cagaatgttg aattgaagta ctgcagcaca   2700

tcattggtca aatgtgcctc tgggaccatg ggatcaataa aaatttgtgc caaagcccca   2760

gttgatagtg gaaaagagaa gttgattccc ttgcttcagg gtccttctga cactaaagac   2820

cttcatagca ccaagtggct caatgagagt agaaagccag agtctctctt agctccagat   2880

ttgatggcct tcacaatcca agttccacaa tatattgact actgccacaa ttccggtgct   2940

gtacttcttt gcagtataca aggactagca gttaatattg acccaatctt atatacgtgg   3000

ctcatctatc agcctcagaa acgaacaagt agacatatgc aacagcagcc tgtggtagct   3060

gttcctcttg ttatgccagt ttgtagaagg aaagaggatg aggtgtctat tggaagtgcc   3120

cccttggcaa agcagcaatc atatcaggcc tctgaatatg ccagcagccc tgtaaaaaca   3180

aaaacggtaa cagaatcccg cccattgtca gttcctgtta aagccatgtt gaatatatct   3240

gaaagctgta gaagtcctga agaaagaatg aaggaattta ttggaattgt ttggaatgca   3300

gtgaagcatc tcacactaca gcttgaagta caatcttgtt gtgtgtttat tccaaatgat   3360

agcctgcctt ccccaagtac aattgtatct ggtgacattc ctggaacagt aagaagttgg   3420

taccatggac aaaccagcat gccgggaaca cttgtcctct gtttgcctca aataaagatt   3480

attagtgctg ggcacaagta tatggaacct ctgcaggaga ttccatttgt tatcccacga   3540

cccatccttg aagaaggtga tgcttttcct tggacgatca gcttgcataa tttcagcata   3600

tatacccttc ttggaaaaca agtgacactt tgcctagtgg aacctatggg ttgcacctcc   3660

actctagctg tcacgtctca aaaactgctt gctacgggac ctgatacacg acattcattt   3720

gttgtctgtc tccatgttga cctagagtca ctagagataa aatgctctaa tccccaggtc   3780

cagctcttct atgaactaac tgatatcatg aataaggtct ggaacaagat tcagaagaga   3840

ggcaatctca acctatctcc aacctctcca gagaccatgg cagggcctgt tcctacttct   3900

ccagttagaa gcagtatagg cacagctcct ccagatacca gcacatgcag cccatctgct   3960

gacattggga ctactactga gggagattct atacaagcag gtgaggaatc accattctca   4020

gattctgtga ccttggaaca aactacaagt aatattggag gaaccagtgg acgtgttagt   4080

ttatggatgc agtgggtgct tcccaaaatt actataaagc tctttgctcc agatcctgaa   4140

aataaaggca cagaggtttg tatggtcagt gaactagaag atctcagtgc ttccatagat   4200

gtccaggatg tatataccaa agtgaaatgt aaaatagaga gtttcaatat tgatcactat   4260

agaagcaggc caggggaagg ttggcagtca ggacattttg aaggagtatt tctacaatgc   4320

aaagaaaaat ctgtgccttg gggaagagtg ttggtctttg gggcaatgtg gaggtgtctt   4380

cctttcctgt actgacaagc tgaacagacg caccttgttg gttcgaccca tcagcaagca   4440

ggaccctttc agtaattgct ctggcttctt tccttctaca actacaaaac ttctagatgg   4500

cactcatcag cagcatggat tcctctctct gacatacaca aaagctgtaa caaaaaatgt   4560

ccgccacaag ttaacatcaa gaaatgagcg aagaagtttt cataagttat ctgaaggcct   4620

aatggatggt tctcctcatt ttcttcatga aattcttctt tcagcacaag cttttgatat   4680

tgttctttat tttcctttac ttaatgccat tgcaagtata tttcaagcaa aactaccaaa   4740

gacccaaaaa gagaaaagaa aatctcctgg tcagcccatg aggacccata cactgacatc   4800

ccgcaattta cctttgattt atgtcaacac aagtgtaatc agaattttta ttccaaaaac   4860

agaagaaatg cagccaactg ttgaagctaa tcaggcagca aaagaagaca ctgtggtttt   4920

gaagattggc tctgttgcca tggctcccca ggctgacaat ccccttggca gatctgtcct   4980

taggaaagat atttaccaga gagccttgaa cttaggaatt cttcgagatc ctggatcaga   5040

aatcgaagac agacaatacc aaatagatct gcagtccatc aatattggta ctgcacagtg   5100

gcatcaacta aaaccagaga aggaaagtgt ctcaggaggg gtggtaacag agactgaaag   5160

gaattctcaa aatccagccc ttgagtggaa tatggccagc agcatacggc ggcatcaaga   5220

aaggagagca attttgaccc ccgttttgac agatttttct gtccgaataa ctggagcacc   5280

tgctgtcatt ttcaccaaag tagtttctcc agaaaatttg catactgagg agattttagt   5340

gtgtggccat tccttagaag tgaatataac cacaaacctg gacttcttcc taagtgtggc   5400

tcaagttcaa ctcttacatc agttaatagt agcaaatatg actggactgg aaccatcaaa   5460

caaggctgca gaggtaactg ttacctgatt ttgatcaggc ttactgcatt tgttccaact   5520

ttacattcac agtaggaaaa ctataattaa gctgactgct ttctgcttaa ttattctgtg   5580

tttaacttta ttcaaaatat agtcataagt cattttggat tgataaaaaa aaaaaaaaaa   5640

aaaaaaaaaa aaaa                                                     5654


<210>  1644
<211>  1427
<212>  PRT
<213>  Homosapiens

<400>  1644

Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg 
1               5                   10                  15      


Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly 
            20                  25                  30          


Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu 
        35                  40                  45              


Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu 
    50                  55                  60                  


Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val 
65                  70                  75                  80  


Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile 
                85                  90                  95      


Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr 
            100                 105                 110         


Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala 
        115                 120                 125             


Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile 
    130                 135                 140                 


Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu 
145                 150                 155                 160 


Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala 
                165                 170                 175     


Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile 
            180                 185                 190         


Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys 
        195                 200                 205             


Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr 
    210                 215                 220                 


Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe 
225                 230                 235                 240 


Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His 
                245                 250                 255     


Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro 
            260                 265                 270         


Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu 
        275                 280                 285             


Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn 
    290                 295                 300                 


Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile 
305                 310                 315                 320 


Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln 
                325                 330                 335     


Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe 
            340                 345                 350         


Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly 
        355                 360                 365             


Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys 
    370                 375                 380                 


Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr 
385                 390                 395                 400 


Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln 
                405                 410                 415     


Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr 
            420                 425                 430         


Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly 
        435                 440                 445             


Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys 
    450                 455                 460                 


Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe 
465                 470                 475                 480 


Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn 
                485                 490                 495     


Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu 
            500                 505                 510         


Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala 
        515                 520                 525             


Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Met 
    530                 535                 540                 


Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser 
545                 550                 555                 560 


Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser 
                565                 570                 575     


Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His 
            580                 585                 590         


Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro 
        595                 600                 605             


Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asp Glu Asn Glu Thr Ile Leu 
    610                 615                 620                 


Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His 
625                 630                 635                 640 


Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu 
                645                 650                 655     


Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn 
            660                 665                 670         


Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu 
        675                 680                 685             


Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val 
    690                 695                 700                 


Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln 
705                 710                 715                 720 


Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys 
                725                 730                 735     


Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser 
            740                 745                 750         


Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr 
        755                 760                 765             


Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile 
    770                 775                 780                 


Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala 
785                 790                 795                 800 


Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser 
                805                 810                 815     


His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn 
            820                 825                 830         


Glu Ile Phe Leu Ser Ile Gly Val Lys Ser Lys Asn Pro Leu Pro Thr 
        835                 840                 845             


Leu Glu Gly Ser Ile Gln Asn Val Glu Leu Lys Tyr Cys Ser Thr Ser 
    850                 855                 860                 


Leu Val Lys Cys Ala Ser Gly Thr Met Gly Ser Ile Lys Ile Cys Ala 
865                 870                 875                 880 


Lys Ala Pro Val Asp Ser Gly Lys Glu Lys Leu Ile Pro Leu Leu Gln 
                885                 890                 895     


Gly Pro Ser Asp Thr Lys Asp Leu His Ser Thr Lys Trp Leu Asn Glu 
            900                 905                 910         


Ser Arg Lys Pro Glu Ser Leu Leu Ala Pro Asp Leu Met Ala Phe Thr 
        915                 920                 925             


Ile Gln Val Pro Gln Tyr Ile Asp Tyr Cys His Asn Ser Gly Ala Val 
    930                 935                 940                 


Leu Leu Cys Ser Ile Gln Gly Leu Ala Val Asn Ile Asp Pro Ile Leu 
945                 950                 955                 960 


Tyr Thr Trp Leu Ile Tyr Gln Pro Gln Lys Arg Thr Ser Arg His Met 
                965                 970                 975     


Gln Gln Gln Pro Val Val Ala Val Pro Leu Val Met Pro Val Cys Arg 
            980                 985                 990         


Arg Lys Glu Asp Glu Val Ser Ile  Gly Ser Ala Pro Leu  Ala Lys Gln 
        995                 1000                 1005             


Gln Ser  Tyr Gln Ala Ser Glu  Tyr Ala Ser Ser Pro  Val Lys Thr 
    1010                 1015                 1020             


Lys Thr  Val Thr Glu Ser Arg  Pro Leu Ser Val Pro  Val Lys Ala 
    1025                 1030                 1035             


Met Leu  Asn Ile Ser Glu Ser  Cys Arg Ser Pro Glu  Glu Arg Met 
    1040                 1045                 1050             


Lys Glu  Phe Ile Gly Ile Val  Trp Asn Ala Val Lys  His Leu Thr 
    1055                 1060                 1065             


Leu Gln  Leu Glu Val Gln Ser  Cys Cys Val Phe Ile  Pro Asn Asp 
    1070                 1075                 1080             


Ser Leu  Pro Ser Pro Ser Thr  Ile Val Ser Gly Asp  Ile Pro Gly 
    1085                 1090                 1095             


Thr Val  Arg Ser Trp Tyr His  Gly Gln Thr Ser Met  Pro Gly Thr 
    1100                 1105                 1110             


Leu Val  Leu Cys Leu Pro Gln  Ile Lys Ile Ile Ser  Ala Gly His 
    1115                 1120                 1125             


Lys Tyr  Met Glu Pro Leu Gln  Glu Ile Pro Phe Val  Ile Pro Arg 
    1130                 1135                 1140             


Pro Ile  Leu Glu Glu Gly Asp  Ala Phe Pro Trp Thr  Ile Ser Leu 
    1145                 1150                 1155             


His Asn  Phe Ser Ile Tyr Thr  Leu Leu Gly Lys Gln  Val Thr Leu 
    1160                 1165                 1170             


Cys Leu  Val Glu Pro Met Gly  Cys Thr Ser Thr Leu  Ala Val Thr 
    1175                 1180                 1185             


Ser Gln  Lys Leu Leu Ala Thr  Gly Pro Asp Thr Arg  His Ser Phe 
    1190                 1195                 1200             


Val Val  Cys Leu His Val Asp  Leu Glu Ser Leu Glu  Ile Lys Cys 
    1205                 1210                 1215             


Ser Asn  Pro Gln Val Gln Leu  Phe Tyr Glu Leu Thr  Asp Ile Met 
    1220                 1225                 1230             


Asn Lys  Val Trp Asn Lys Ile  Gln Lys Arg Gly Asn  Leu Asn Leu 
    1235                 1240                 1245             


Ser Pro  Thr Ser Pro Glu Thr  Met Ala Gly Pro Val  Pro Thr Ser 
    1250                 1255                 1260             


Pro Val  Arg Ser Ser Ile Gly  Thr Ala Pro Pro Asp  Thr Ser Thr 
    1265                 1270                 1275             


Cys Ser  Pro Ser Ala Asp Ile  Gly Thr Thr Thr Glu  Gly Asp Ser 
    1280                 1285                 1290             


Ile Gln  Ala Gly Glu Glu Ser  Pro Phe Ser Asp Ser  Val Thr Leu 
    1295                 1300                 1305             


Glu Gln  Thr Thr Ser Asn Ile  Gly Gly Thr Ser Gly  Arg Val Ser 
    1310                 1315                 1320             


Leu Trp  Met Gln Trp Val Leu  Pro Lys Ile Thr Ile  Lys Leu Phe 
    1325                 1330                 1335             


Ala Pro  Asp Pro Glu Asn Lys  Gly Thr Glu Val Cys  Met Val Ser 
    1340                 1345                 1350             


Glu Leu  Glu Asp Leu Ser Ala  Ser Ile Asp Val Gln  Asp Val Tyr 
    1355                 1360                 1365             


Thr Lys  Val Lys Cys Lys Ile  Glu Ser Phe Asn Ile  Asp His Tyr 
    1370                 1375                 1380             


Arg Ser  Arg Pro Gly Glu Gly  Trp Gln Ser Gly His  Phe Glu Gly 
    1385                 1390                 1395             


Val Phe  Leu Gln Cys Lys Glu  Lys Ser Val Pro Trp  Gly Arg Val 
    1400                 1405                 1410             


Leu Val  Phe Gly Ala Met Trp  Arg Cys Leu Pro Phe  Leu Tyr 
    1415                 1420                 1425         


<210>  1645
<211>  3870
<212>  DNA
<213>  Homosapiens

<400>  1645
ggggctcccc agtcccggca ggtcctggcg ccgctgtaca tagaaaccgt tgccacggcg     60

ggaggatgcc gtttcttttc ggtctccgac tgcagggggc ggtcggccct gtggatgcag    120

gaaagagggt gcctcggtgg gagagaccca gcttttcgcg ttagtaggcc cgagcagttt    180

gaactggagc tatgaccacc aaagattatc catcattgtg gggctttgga acaacaaaaa    240

cattcaaaat tcccattgaa catctagatt tcaaatacat tgaaaaatgt tcagatgtta    300

aacatctgga aaaaattctt tgcgtgctca gatctggtga ggaaggatat tatcctgaac    360

ttacagaatt ttgtgaaaag catcttcaag ccttggcccc tgaaagcaga gctttgagga    420

aagataaacc agcagcaaca gcagccagtt ttacagctga agaatgggaa aaaattgatg    480

gtgatataaa gagttgggta tcagaaatta aaaaagaaga agataaaatg cactttcatg    540

aaactgagac atttccagca atgaaagata atttgcctcc agttcgtggt tcaaacagct    600

gtcttcatgt aggcaaggaa aaatattcta aaagaccaac taaaaagaaa actccaaggg    660

attacgcgga atgggataaa tttgacgtgg agaaggaatg tttaaaaatt gatgaagatt    720

acaaagaaaa gacggtaata gacaagtcac acttgtctaa aattgagaca agaatagata    780

cagcaggtct aactgagaaa gaaaaggatt ttcttgccac tcgtgaaaag gagaaaggaa    840

atgaagcttt caactcagga gattatgaag aagcagtgat gtattatacc aggagcatat    900

cagcgcttcc cactgtagtt gcctataaca atcgagctca agcagaaatc aaattacaga    960

actggaatag tgcttttcag gattgtgaaa aggtcttgga gttagaacct ggaaacgtaa   1020

aggctcttct gcgtcgtgct actacatata aacatcaaaa caagctccgg gaagctacag   1080

aagatttgag taaagtacta gatgttgagc ctgataatga tttggccaag aaaaccttgt   1140

cagaggttga aagagatctg aaaaattctg aagctgcatc tgagactcaa accaaaggga   1200

aaaggatggt tattcaggaa atagaaaact ccgaagatga agaaggaaaa agcggaagaa   1260

aacatgaaga tggcggtgga gataagaagc ccgcggagcc ggcgggagcc gcgcgcgccg   1320

cccagccgtg cgtcatgggc aacatccaga agaagctgac tggcaaagcc gaaggcggca   1380

agcggccggc aaggggcgcg ccgcagcggg gccagacccc ggaggccggc gcggacaagc   1440

ggagcccacg gcgggcctct gcggcggcgg cggcgggcgg cggcgccacc gggcatccgg   1500

gcggcgggca gggcgcggag aaccctgccg gcctgaagag ccagggcaac gagctgttcc   1560

gaagcgggca gttcgccgag gcggccggca agtactcggc ggcaatcgcg ctcctggagc   1620

cagcaggaag tgaaattgca gatgatctaa gtatcttata ttcaaataga gcagcatgtt   1680

acctaaaaga aggaaactgc agtggctgca ttcaagattg taacagggct ctggaacttc   1740

atccattctc tatgaaacct cttctgaggc gggcgatggc ctatgaaact ctagagcagt   1800

atgggaaagc ttatgtggat tataaaacag tgttgcagat agactgtgga ctccagctag   1860

caaatgacag tgttaacagg ctatcaagaa ttttaatgga gctggatgga ccaaattggc   1920

gggagaagct gtcacctatt cctgctgtgc ctgcttctgt gccactgcaa gcttggcatc   1980

cggcaaaaga gatgatctca aaacaagcag gagactccag cagccatcgc cagcagggca   2040

tcacagatga aaaaacattt aaagccctta aggaagaagg aaatcaatgt gtaaatgaca   2100

aaaactataa agacgccctc agtaaataca gcgaatgctt aaagattaac aataaggaat   2160

gtgccatata tacaaacaga gctctctgtt acttgaagct gtgccagttt gaagaagcaa   2220

agcaggactg tgatcaggca cttcagctag ctgatgggaa cgtgaaagcc ttctatagac   2280

gagctctggc tcataaagga ctcaagaatt atcagaaaag cttaattgat ctcaataaag   2340

ttatcctact agatccaagt attattgagg caaagatgga actggaagag gtaactagac   2400

tccttaatct taaggataag acagcaccat tcaacaaaga aaaggagaga aggaaaattg   2460

agattcaaga ggtgaatgaa ggcaaggagg agcctggaag acctgcaggg gaggtctcca   2520

tgggatgcct tgcttctgag aagggaggca aaagcagcag gtcaccagaa gaccctgaga   2580

aacttccgat agccaagcct aataatgcct atgaatttgg tcagattata aatgctctca   2640

gtaccaggaa ggataaagaa gcctgtgcac atcttttagc catcactgca ccaaaagatt   2700

tgccgatgtt tttaagtaac aaacttgaag gggatacatt ccttctcctc attcagtctc   2760

tgaaaaataa tcttattgaa aaagatccct cattggtgta tcagcatctt ttatacctga   2820

gtaaagcaga aaggtttaag atgatgttga cactaattag caagggccaa aaggagctaa   2880

ttgaacagct gtttgaggac ctttcggaca caccaaacaa ccattttact ttagaagata   2940

tacaggccct aaaaaggcag tatgagcttt aaatcaagat aattgttaga tttcttccat   3000

gcatgtatgt gttccaggaa tgttaatgag atggtattgt aaaagagttg catggataaa   3060

acttggccta gaaaagtttg gtctgcacta taaaacattt tacttatttt cctacataga   3120

acatgtatat tctacaatct gctttttatt agttgtaaat attttcttat gtaccagaac   3180

caaataagta tatttagaac ttgttaaaaa tacattttaa tttatgatat acatattatt   3240

ttaattactt gttaaaattt tgagttaagt tgcatttctt tgggctatga aggagtcctc   3300

ttaagtttga tagaaatgaa tttcttgtaa cattcttttt taaaagtgga agtcattaac   3360

agtgattatt atatcactta tatcctgcta agatacacat aaatcccatt ttgtactagt   3420

acctgtggat tacagtcagt taaaatgaaa tgcaacactg aagtctataa catgaaatga   3480

ttattaaatt gtttattaat ttagagctat aagaggaact tattttttct aatacggaag   3540

cattgcctaa taattaagaa caaaaattgc caaaaatttc taccactttt tactagattt   3600

taaaaagcta ctttctttta tattgcctat ataagcaaaa aaccaaccac tgtattaaag   3660

caaactaagc ctgcatttat atctgaatta ttacctccat attttaccaa acatttgaat   3720

gtcccccttc cccctttttt gttttctgct tttatgactg tatttattcc tttactgtaa   3780

aagaatatga agaactcata catgttgaaa gctcctttgt tgactgggtc aaagtgaagg   3840

aatttcaatc tcaaaaaaaa aaaaaaaaaa                                    3870


<210>  1646
<211>  926
<212>  PRT
<213>  Homosapiens

<400>  1646

Met Thr Thr Lys Asp Tyr Pro Ser Leu Trp Gly Phe Gly Thr Thr Lys 
1               5                   10                  15      


Thr Phe Lys Ile Pro Ile Glu His Leu Asp Phe Lys Tyr Ile Glu Lys 
            20                  25                  30          


Cys Ser Asp Val Lys His Leu Glu Lys Ile Leu Cys Val Leu Arg Ser 
        35                  40                  45              


Gly Glu Glu Gly Tyr Tyr Pro Glu Leu Thr Glu Phe Cys Glu Lys His 
    50                  55                  60                  


Leu Gln Ala Leu Ala Pro Glu Ser Arg Ala Leu Arg Lys Asp Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Ala Ala Ser Phe Thr Ala Glu Glu Trp Glu Lys Ile Asp 
                85                  90                  95      


Gly Asp Ile Lys Ser Trp Val Ser Glu Ile Lys Lys Glu Glu Asp Lys 
            100                 105                 110         


Met His Phe His Glu Thr Glu Thr Phe Pro Ala Met Lys Asp Asn Leu 
        115                 120                 125             


Pro Pro Val Arg Gly Ser Asn Ser Cys Leu His Val Gly Lys Glu Lys 
    130                 135                 140                 


Tyr Ser Lys Arg Pro Thr Lys Lys Lys Thr Pro Arg Asp Tyr Ala Glu 
145                 150                 155                 160 


Trp Asp Lys Phe Asp Val Glu Lys Glu Cys Leu Lys Ile Asp Glu Asp 
                165                 170                 175     


Tyr Lys Glu Lys Thr Val Ile Asp Lys Ser His Leu Ser Lys Ile Glu 
            180                 185                 190         


Thr Arg Ile Asp Thr Ala Gly Leu Thr Glu Lys Glu Lys Asp Phe Leu 
        195                 200                 205             


Ala Thr Arg Glu Lys Glu Lys Gly Asn Glu Ala Phe Asn Ser Gly Asp 
    210                 215                 220                 


Tyr Glu Glu Ala Val Met Tyr Tyr Thr Arg Ser Ile Ser Ala Leu Pro 
225                 230                 235                 240 


Thr Val Val Ala Tyr Asn Asn Arg Ala Gln Ala Glu Ile Lys Leu Gln 
                245                 250                 255     


Asn Trp Asn Ser Ala Phe Gln Asp Cys Glu Lys Val Leu Glu Leu Glu 
            260                 265                 270         


Pro Gly Asn Val Lys Ala Leu Leu Arg Arg Ala Thr Thr Tyr Lys His 
        275                 280                 285             


Gln Asn Lys Leu Arg Glu Ala Thr Glu Asp Leu Ser Lys Val Leu Asp 
    290                 295                 300                 


Val Glu Pro Asp Asn Asp Leu Ala Lys Lys Thr Leu Ser Glu Val Glu 
305                 310                 315                 320 


Arg Asp Leu Lys Asn Ser Glu Ala Ala Ser Glu Thr Gln Thr Lys Gly 
                325                 330                 335     


Lys Arg Met Val Ile Gln Glu Ile Glu Asn Ser Glu Asp Glu Glu Gly 
            340                 345                 350         


Lys Ser Gly Arg Lys His Glu Asp Gly Gly Gly Asp Lys Lys Pro Ala 
        355                 360                 365             


Glu Pro Ala Gly Ala Ala Arg Ala Ala Gln Pro Cys Val Met Gly Asn 
    370                 375                 380                 


Ile Gln Lys Lys Leu Thr Gly Lys Ala Glu Gly Gly Lys Arg Pro Ala 
385                 390                 395                 400 


Arg Gly Ala Pro Gln Arg Gly Gln Thr Pro Glu Ala Gly Ala Asp Lys 
                405                 410                 415     


Arg Ser Pro Arg Arg Ala Ser Ala Ala Ala Ala Ala Gly Gly Gly Ala 
            420                 425                 430         


Thr Gly His Pro Gly Gly Gly Gln Gly Ala Glu Asn Pro Ala Gly Leu 
        435                 440                 445             


Lys Ser Gln Gly Asn Glu Leu Phe Arg Ser Gly Gln Phe Ala Glu Ala 
    450                 455                 460                 


Ala Gly Lys Tyr Ser Ala Ala Ile Ala Leu Leu Glu Pro Ala Gly Ser 
465                 470                 475                 480 


Glu Ile Ala Asp Asp Leu Ser Ile Leu Tyr Ser Asn Arg Ala Ala Cys 
                485                 490                 495     


Tyr Leu Lys Glu Gly Asn Cys Ser Gly Cys Ile Gln Asp Cys Asn Arg 
            500                 505                 510         


Ala Leu Glu Leu His Pro Phe Ser Met Lys Pro Leu Leu Arg Arg Ala 
        515                 520                 525             


Met Ala Tyr Glu Thr Leu Glu Gln Tyr Gly Lys Ala Tyr Val Asp Tyr 
    530                 535                 540                 


Lys Thr Val Leu Gln Ile Asp Cys Gly Leu Gln Leu Ala Asn Asp Ser 
545                 550                 555                 560 


Val Asn Arg Leu Ser Arg Ile Leu Met Glu Leu Asp Gly Pro Asn Trp 
                565                 570                 575     


Arg Glu Lys Leu Ser Pro Ile Pro Ala Val Pro Ala Ser Val Pro Leu 
            580                 585                 590         


Gln Ala Trp His Pro Ala Lys Glu Met Ile Ser Lys Gln Ala Gly Asp 
        595                 600                 605             


Ser Ser Ser His Arg Gln Gln Gly Ile Thr Asp Glu Lys Thr Phe Lys 
    610                 615                 620                 


Ala Leu Lys Glu Glu Gly Asn Gln Cys Val Asn Asp Lys Asn Tyr Lys 
625                 630                 635                 640 


Asp Ala Leu Ser Lys Tyr Ser Glu Cys Leu Lys Ile Asn Asn Lys Glu 
                645                 650                 655     


Cys Ala Ile Tyr Thr Asn Arg Ala Leu Cys Tyr Leu Lys Leu Cys Gln 
            660                 665                 670         


Phe Glu Glu Ala Lys Gln Asp Cys Asp Gln Ala Leu Gln Leu Ala Asp 
        675                 680                 685             


Gly Asn Val Lys Ala Phe Tyr Arg Arg Ala Leu Ala His Lys Gly Leu 
    690                 695                 700                 


Lys Asn Tyr Gln Lys Ser Leu Ile Asp Leu Asn Lys Val Ile Leu Leu 
705                 710                 715                 720 


Asp Pro Ser Ile Ile Glu Ala Lys Met Glu Leu Glu Glu Val Thr Arg 
                725                 730                 735     


Leu Leu Asn Leu Lys Asp Lys Thr Ala Pro Phe Asn Lys Glu Lys Glu 
            740                 745                 750         


Arg Arg Lys Ile Glu Ile Gln Glu Val Asn Glu Gly Lys Glu Glu Pro 
        755                 760                 765             


Gly Arg Pro Ala Gly Glu Val Ser Met Gly Cys Leu Ala Ser Glu Lys 
    770                 775                 780                 


Gly Gly Lys Ser Ser Arg Ser Pro Glu Asp Pro Glu Lys Leu Pro Ile 
785                 790                 795                 800 


Ala Lys Pro Asn Asn Ala Tyr Glu Phe Gly Gln Ile Ile Asn Ala Leu 
                805                 810                 815     


Ser Thr Arg Lys Asp Lys Glu Ala Cys Ala His Leu Leu Ala Ile Thr 
            820                 825                 830         


Ala Pro Lys Asp Leu Pro Met Phe Leu Ser Asn Lys Leu Glu Gly Asp 
        835                 840                 845             


Thr Phe Leu Leu Leu Ile Gln Ser Leu Lys Asn Asn Leu Ile Glu Lys 
    850                 855                 860                 


Asp Pro Ser Leu Val Tyr Gln His Leu Leu Tyr Leu Ser Lys Ala Glu 
865                 870                 875                 880 


Arg Phe Lys Met Met Leu Thr Leu Ile Ser Lys Gly Gln Lys Glu Leu 
                885                 890                 895     


Ile Glu Gln Leu Phe Glu Asp Leu Ser Asp Thr Pro Asn Asn His Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Gln Ala Leu Lys Arg Gln Tyr Glu Leu 
        915                 920                 925     


<210>  1647
<211>  3765
<212>  DNA
<213>  Homosapiens

<400>  1647
gacgagaccc tccctcagca cctgcagtgc agccagagcc ggtgcggcgg ccgcgacttc     60

cccgacgcgg ggcgctgaga agcactatga ccaccaaaga ttatccatca ttgtggggct    120

ttggaacaac aaaaacattc aaaattccca ttgaacatct agatttcaaa tacattgaaa    180

aatgttcaga tgttaaacat ctggaaaaaa ttctttgcgt gctcagatct ggtgaggaag    240

gatattatcc tgaacttaca gaattttgtg aaaagcatct tcaagccttg gcccctgaaa    300

gcagagcttt gaggaaagat aaaccagcag caacagcagc cagttttaca gctgaagaat    360

gggaaaaaat tgatggtgat ataaagagtt gggtatcaga aattaaaaaa gaagaagata    420

aaatgcactt tcatgaaact gagacatttc cagcaatgaa agataatttg cctccagttc    480

gtggttcaaa cagctgtctt catgtaggca aggaaaaata ttctaaaaga ccaactaaaa    540

agaaaactcc aagggattac gcggaatggg ataaatttga cgtggagaag gaatgtttaa    600

aaattgatga agattacaaa gaaaagacgg taatagacaa gtcacacttg tctaaaattg    660

agacaagaat agatacagca ggtctaactg agaaagaaaa ggattttctt gccactcgtg    720

aaaaggagaa aggaaatgaa gctttcaact caggagatta tgaagaagca gtgatgtatt    780

ataccaggag catatcagcg cttcccactg tagttgccta taacaatcga gctcaagcag    840

aaatcaaatt acagaactgg aatagtgctt ttcaggattg tgaaaaggtc ttggagttag    900

aacctggaaa cgtaaaggct cttctgcgtc gtgctactac atataaacat caaaacaagc    960

tccgggaagc tacagaagat ttgagtaaag tactagatgt tgagcctgat aatgatttgg   1020

ccaagaaaac cttgtcagag gttgaaagag atctgaaaaa ttctgaagct gcatctgaga   1080

ctcaaaccaa agggaaaagg atggttattc aggaaataga aaactccgaa gatgaagaag   1140

gaaaaagcgg aagaaaacat gaagatggcg gtggagataa gaagcccgcg gagccggcgg   1200

gagccgcgcg cgccgcccag ccgtgcgtca tgggcaacat ccagaagaag ctgactggca   1260

aagccgaagg cggcaagcgg ccggcaaggg gcgcgccgca gcggggccag accccggagg   1320

ccggcgcgga caagcggagc ccacggcggg cctctgcggc ggcggcggcg ggcggcggcg   1380

ccaccgggca tccgggcggc gggcagggcg cggagaaccc tgccggcctg aagagccagg   1440

gcaacgagct gttccgaagc gggcagttcg ccgaggcggc cggcaagtac tcggcggcaa   1500

tcgcgctcct ggagccagca ggaagtgaaa ttgcagatga tctaagtatc ttatattcaa   1560

atagagcagc atgttaccta aaagaaggaa actgcagtgg ctgcattcaa gattgtaaca   1620

gggctctgga acttcatcca ttctctatga aacctcttct gaggcgggcg atggcctatg   1680

aaactctaga gcagtatggg aaagcttatg tggattataa aacagtgttg cagatagact   1740

gtggactcca gctagcaaat gacagtgtta acaggctatc aagaatttta atggagctgg   1800

atggaccaaa ttggcgggag aagctgtcac ctattcctgc tgtgcctgct tctgtgccac   1860

tgcaagcttg gcatccggca aaagagatga tctcaaaaca agcaggagac tccagcagcc   1920

atcgccagca gggcatcaca gatgaaaaaa catttaaagc ccttaaggaa gaaggaaatc   1980

aatgtgtaaa tgacaaaaac tataaagacg ccctcagtaa atacagcgaa tgcttaaaga   2040

ttaacaataa ggaatgtgcc atatatacaa acagagctct ctgttacttg aagctgtgcc   2100

agtttgaaga agcaaagcag gactgtgatc aggcacttca gctagctgat gggaacgtga   2160

aagccttcta tagacgagct ctggctcata aaggactcaa gaattatcag aaaagcttaa   2220

ttgatctcaa taaagttatc ctactagatc caagtattat tgaggcaaag atggaactgg   2280

aagaggtaac tagactcctt aatcttaagg ataagacagc accattcaac aaagaaaagg   2340

agagaaggaa aattgagatt caagaggtga atgaaggcaa ggaggagcct ggaagacctg   2400

caggggaggt ctccatggga tgccttgctt ctgagaaggg aggcaaaagc agcaggtcac   2460

cagaagaccc tgagaaactt ccgatagcca agcctaataa tgcctatgaa tttggtcaga   2520

ttataaatgc tctcagtacc aggaaggata aagaagcctg tgcacatctt ttagccatca   2580

ctgcaccaaa agatttgccg atgtttttaa gtaacaaact tgaaggggat acattccttc   2640

tcctcattca gtctctgaaa aataatctta ttgaaaaaga tccctcattg gtgtatcagc   2700

atcttttata cctgagtaaa gcagaaaggt ttaagatgat gttgacacta attagcaagg   2760

gccaaaagga gctaattgaa cagctgtttg aggacctttc ggacacacca aacaaccatt   2820

ttactttaga agatatacag gccctaaaaa ggcagtatga gctttaaatc aagataattg   2880

ttagatttct tccatgcatg tatgtgttcc aggaatgtta atgagatggt attgtaaaag   2940

agttgcatgg ataaaacttg gcctagaaaa gtttggtctg cactataaaa cattttactt   3000

attttcctac atagaacatg tatattctac aatctgcttt ttattagttg taaatatttt   3060

cttatgtacc agaaccaaat aagtatattt agaacttgtt aaaaatacat tttaatttat   3120

gatatacata ttattttaat tacttgttaa aattttgagt taagttgcat ttctttgggc   3180

tatgaaggag tcctcttaag tttgatagaa atgaatttct tgtaacattc ttttttaaaa   3240

gtggaagtca ttaacagtga ttattatatc acttatatcc tgctaagata cacataaatc   3300

ccattttgta ctagtacctg tggattacag tcagttaaaa tgaaatgcaa cactgaagtc   3360

tataacatga aatgattatt aaattgttta ttaatttaga gctataagag gaacttattt   3420

tttctaatac ggaagcattg cctaataatt aagaacaaaa attgccaaaa atttctacca   3480

ctttttacta gattttaaaa agctactttc ttttatattg cctatataag caaaaaacca   3540

accactgtat taaagcaaac taagcctgca tttatatctg aattattacc tccatatttt   3600

accaaacatt tgaatgtccc ccttccccct tttttgtttt ctgcttttat gactgtattt   3660

attcctttac tgtaaaagaa tatgaagaac tcatacatgt tgaaagctcc tttgttgact   3720

gggtcaaagt gaaggaattt caatctcaaa aaaaaaaaaa aaaaa                   3765


<210>  1648
<211>  926
<212>  PRT
<213>  Homosapiens

<400>  1648

Met Thr Thr Lys Asp Tyr Pro Ser Leu Trp Gly Phe Gly Thr Thr Lys 
1               5                   10                  15      


Thr Phe Lys Ile Pro Ile Glu His Leu Asp Phe Lys Tyr Ile Glu Lys 
            20                  25                  30          


Cys Ser Asp Val Lys His Leu Glu Lys Ile Leu Cys Val Leu Arg Ser 
        35                  40                  45              


Gly Glu Glu Gly Tyr Tyr Pro Glu Leu Thr Glu Phe Cys Glu Lys His 
    50                  55                  60                  


Leu Gln Ala Leu Ala Pro Glu Ser Arg Ala Leu Arg Lys Asp Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Ala Ala Ser Phe Thr Ala Glu Glu Trp Glu Lys Ile Asp 
                85                  90                  95      


Gly Asp Ile Lys Ser Trp Val Ser Glu Ile Lys Lys Glu Glu Asp Lys 
            100                 105                 110         


Met His Phe His Glu Thr Glu Thr Phe Pro Ala Met Lys Asp Asn Leu 
        115                 120                 125             


Pro Pro Val Arg Gly Ser Asn Ser Cys Leu His Val Gly Lys Glu Lys 
    130                 135                 140                 


Tyr Ser Lys Arg Pro Thr Lys Lys Lys Thr Pro Arg Asp Tyr Ala Glu 
145                 150                 155                 160 


Trp Asp Lys Phe Asp Val Glu Lys Glu Cys Leu Lys Ile Asp Glu Asp 
                165                 170                 175     


Tyr Lys Glu Lys Thr Val Ile Asp Lys Ser His Leu Ser Lys Ile Glu 
            180                 185                 190         


Thr Arg Ile Asp Thr Ala Gly Leu Thr Glu Lys Glu Lys Asp Phe Leu 
        195                 200                 205             


Ala Thr Arg Glu Lys Glu Lys Gly Asn Glu Ala Phe Asn Ser Gly Asp 
    210                 215                 220                 


Tyr Glu Glu Ala Val Met Tyr Tyr Thr Arg Ser Ile Ser Ala Leu Pro 
225                 230                 235                 240 


Thr Val Val Ala Tyr Asn Asn Arg Ala Gln Ala Glu Ile Lys Leu Gln 
                245                 250                 255     


Asn Trp Asn Ser Ala Phe Gln Asp Cys Glu Lys Val Leu Glu Leu Glu 
            260                 265                 270         


Pro Gly Asn Val Lys Ala Leu Leu Arg Arg Ala Thr Thr Tyr Lys His 
        275                 280                 285             


Gln Asn Lys Leu Arg Glu Ala Thr Glu Asp Leu Ser Lys Val Leu Asp 
    290                 295                 300                 


Val Glu Pro Asp Asn Asp Leu Ala Lys Lys Thr Leu Ser Glu Val Glu 
305                 310                 315                 320 


Arg Asp Leu Lys Asn Ser Glu Ala Ala Ser Glu Thr Gln Thr Lys Gly 
                325                 330                 335     


Lys Arg Met Val Ile Gln Glu Ile Glu Asn Ser Glu Asp Glu Glu Gly 
            340                 345                 350         


Lys Ser Gly Arg Lys His Glu Asp Gly Gly Gly Asp Lys Lys Pro Ala 
        355                 360                 365             


Glu Pro Ala Gly Ala Ala Arg Ala Ala Gln Pro Cys Val Met Gly Asn 
    370                 375                 380                 


Ile Gln Lys Lys Leu Thr Gly Lys Ala Glu Gly Gly Lys Arg Pro Ala 
385                 390                 395                 400 


Arg Gly Ala Pro Gln Arg Gly Gln Thr Pro Glu Ala Gly Ala Asp Lys 
                405                 410                 415     


Arg Ser Pro Arg Arg Ala Ser Ala Ala Ala Ala Ala Gly Gly Gly Ala 
            420                 425                 430         


Thr Gly His Pro Gly Gly Gly Gln Gly Ala Glu Asn Pro Ala Gly Leu 
        435                 440                 445             


Lys Ser Gln Gly Asn Glu Leu Phe Arg Ser Gly Gln Phe Ala Glu Ala 
    450                 455                 460                 


Ala Gly Lys Tyr Ser Ala Ala Ile Ala Leu Leu Glu Pro Ala Gly Ser 
465                 470                 475                 480 


Glu Ile Ala Asp Asp Leu Ser Ile Leu Tyr Ser Asn Arg Ala Ala Cys 
                485                 490                 495     


Tyr Leu Lys Glu Gly Asn Cys Ser Gly Cys Ile Gln Asp Cys Asn Arg 
            500                 505                 510         


Ala Leu Glu Leu His Pro Phe Ser Met Lys Pro Leu Leu Arg Arg Ala 
        515                 520                 525             


Met Ala Tyr Glu Thr Leu Glu Gln Tyr Gly Lys Ala Tyr Val Asp Tyr 
    530                 535                 540                 


Lys Thr Val Leu Gln Ile Asp Cys Gly Leu Gln Leu Ala Asn Asp Ser 
545                 550                 555                 560 


Val Asn Arg Leu Ser Arg Ile Leu Met Glu Leu Asp Gly Pro Asn Trp 
                565                 570                 575     


Arg Glu Lys Leu Ser Pro Ile Pro Ala Val Pro Ala Ser Val Pro Leu 
            580                 585                 590         


Gln Ala Trp His Pro Ala Lys Glu Met Ile Ser Lys Gln Ala Gly Asp 
        595                 600                 605             


Ser Ser Ser His Arg Gln Gln Gly Ile Thr Asp Glu Lys Thr Phe Lys 
    610                 615                 620                 


Ala Leu Lys Glu Glu Gly Asn Gln Cys Val Asn Asp Lys Asn Tyr Lys 
625                 630                 635                 640 


Asp Ala Leu Ser Lys Tyr Ser Glu Cys Leu Lys Ile Asn Asn Lys Glu 
                645                 650                 655     


Cys Ala Ile Tyr Thr Asn Arg Ala Leu Cys Tyr Leu Lys Leu Cys Gln 
            660                 665                 670         


Phe Glu Glu Ala Lys Gln Asp Cys Asp Gln Ala Leu Gln Leu Ala Asp 
        675                 680                 685             


Gly Asn Val Lys Ala Phe Tyr Arg Arg Ala Leu Ala His Lys Gly Leu 
    690                 695                 700                 


Lys Asn Tyr Gln Lys Ser Leu Ile Asp Leu Asn Lys Val Ile Leu Leu 
705                 710                 715                 720 


Asp Pro Ser Ile Ile Glu Ala Lys Met Glu Leu Glu Glu Val Thr Arg 
                725                 730                 735     


Leu Leu Asn Leu Lys Asp Lys Thr Ala Pro Phe Asn Lys Glu Lys Glu 
            740                 745                 750         


Arg Arg Lys Ile Glu Ile Gln Glu Val Asn Glu Gly Lys Glu Glu Pro 
        755                 760                 765             


Gly Arg Pro Ala Gly Glu Val Ser Met Gly Cys Leu Ala Ser Glu Lys 
    770                 775                 780                 


Gly Gly Lys Ser Ser Arg Ser Pro Glu Asp Pro Glu Lys Leu Pro Ile 
785                 790                 795                 800 


Ala Lys Pro Asn Asn Ala Tyr Glu Phe Gly Gln Ile Ile Asn Ala Leu 
                805                 810                 815     


Ser Thr Arg Lys Asp Lys Glu Ala Cys Ala His Leu Leu Ala Ile Thr 
            820                 825                 830         


Ala Pro Lys Asp Leu Pro Met Phe Leu Ser Asn Lys Leu Glu Gly Asp 
        835                 840                 845             


Thr Phe Leu Leu Leu Ile Gln Ser Leu Lys Asn Asn Leu Ile Glu Lys 
    850                 855                 860                 


Asp Pro Ser Leu Val Tyr Gln His Leu Leu Tyr Leu Ser Lys Ala Glu 
865                 870                 875                 880 


Arg Phe Lys Met Met Leu Thr Leu Ile Ser Lys Gly Gln Lys Glu Leu 
                885                 890                 895     


Ile Glu Gln Leu Phe Glu Asp Leu Ser Asp Thr Pro Asn Asn His Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Gln Ala Leu Lys Arg Gln Tyr Glu Leu 
        915                 920                 925     


<210>  1649
<211>  4357
<212>  DNA
<213>  Homosapiens

<400>  1649
atagtcacca gaagctggaa gagtcaaagg acacattctc ccctcaagcc ccagtgggag     60

cacggcccag ctggattttg gacttctggc ctccagaact agacagggcc tcactgtgtc    120

acccagggtg gaatacagtg gtgtgatcat agctcactgc agcctggaat tcctgggctc    180

aagcaaccct gccacctcag ccttccaagt agctaggact acagaacatc catgatagca    240

gtcttctgta aatcgaactt ttcaagaatt ctctgaagga accaagtagg atattcttac    300

atcatgactt aatgtgaatg caagaacaag aaataggttt tatctctaaa tataatgaag    360

ggctgtgtgt aaacactgac cctgtctcaa ttctaacaag cattttagac atgagtttac    420

atcggcaaat gggttcagat cgagatcttc agtcctctgc ttcatctgtg agcttgcctt    480

cagtcaaaaa ggcacccaaa aaaagaagaa tttcaatagg ctccctgttt cggaggaaaa    540

aagataacaa acgtaaatca agggagctaa atggcggggt ggatggaatt gcaagtattg    600

aaagtataca ttctgaaatg tgtactgata agaactccat tttctctaca aatacctctt    660

ctgacaatgg attaacttcc atcagcaaac aaattggaga cttcatagag tgccctttgt    720

gccttttgcg gcattctaaa gacagatttc ctgatataat gacttgtcat cacagatctt    780

gtgtggattg cttacgacaa tatttaagga tagaaatctc tgaaagcaga gttaatatta    840

gttgcccaga atgtactgaa cggtttaatc cccatgatat tcgcttgata ttaagtgatg    900

atgtcttgat ggaaaaatac gaagaattta tgcttagacg gtggcttgtt gcagatcctg    960

attgtaggtg gtgtccagct ccagactgtg gatatgctgt gatagcattt ggatgtgcca   1020

gctgtccaaa attaacttgt gggcgagagg gctgtggaac agagttttgc taccactgta   1080

aacagatttg gcaccccaac cagacctgtg atgctgctcg acaagagaga gcccagagct   1140

tacgtttgag aactatacgt tcttcatcca ttagttatag tcaagagtct ggagcagcag   1200

ctgatgatat aaagccatgt ccacgatgtg ctgcttatat aataaagatg aatgatggga   1260

gctgcaatca catgacatgt gctgtttgtg gttgtgagtt ttgttggttg tgtatgaaag   1320

aaatctcaga tttgcattat ctaagtccat caggatgtac tttttggggg aagaaaccct   1380

ggagccgaaa gaagaaaata ttgtggcaac tgggaacact ggttggtgct cctgtcggaa   1440

tcgctttaat agctggcatt gctattcctg caatgattat tggcattcct gtgtatgtgg   1500

gccgcaagat tcacaatcgc tatgaaggca aggatgtttc aaagcacaaa cggaatttgg   1560

ccatagcagg tggtgtaacg ttgtctgtaa tcgtgtctcc agtagtagct gcagtgactg   1620

taggtatcgg tgttcctatt atgttagctt atgtctatgg cgtagttcca atttctcttt   1680

gtcgaagcgg aggttgtgga gtctcagcag gcaatggaaa aggagttagg attgaatttg   1740

atgatgaaaa tgatataaat gttggtggaa ctaacacagc tgtagacaca acatcagtag   1800

cagaagcaag acacaaccca agcatagggg agggaagtgt tggtgggctg actggcagtt   1860

tgagtgcaag tggaagccac atggatcgaa taggagccat ccgagacaac ctgagtgaaa   1920

cggccagcac catggcacta gctggagcca gtataacggg gagtctgtca ggaagtgcca   1980

tggtaaactg ttttaacagg ttggaagtac aagcagatgt acagaaagaa cggtacagtc   2040

taagtggaga atctggcaca gtcagcttgg gaacagttag tgataatgcc agcaccaaag   2100

caatggcagg atccattctg aattcctaca tcccattgga caaagaaggc aacagtatgg   2160

aggtgcaagt agatattgag tcaaagccat ccaaattcag gcacaacagt ggaagcagta   2220

gtgtggatga tggcagtgcc acccgaagtc atgctggcgg ttcatccagt ggcttgcctg   2280

aaggtaaatc tagtgccacc aagtggtcca aagaagcaac agcagggaaa aaatcaaaaa   2340

gtggtaaact gaggaaaaag ggtaacatga agataaatga gacgagagag gacatggatg   2400

cacagttgtt agaacaacaa agcacgaact caagtgaatt tgaggctcca tccctcagtg   2460

acagtatgcc ttctgtagca gattctcact ctagtcattt ttctgaattt agttgttctg   2520

acctagaaag catgaaaact tcttgtagtc atggttccag tgattatcac acccgctttg   2580

ctactgttaa cattcttcct gaggtagaaa atgaccgtct ggaaaattcc ccacatcagt   2640

gtagcatttc tgtggttacc caaactgctt cctgttcaga agtttcacag ttgaatcata   2700

ttgctgaaga acatggtaac aatggaataa aacctaatgt tgatttatat tttggcgatg   2760

cactaaaaga aacaaataac aaccactcac atcagacaat ggaattaaaa gttgcaattc   2820

agactgaaat ttaggcccat aaatgctgca gaataattac cactgtacaa ccgtgtttgg   2880

agctggttga actacatgtg actacttaag tttcaggtta ccagcaaaag ccgggtttca   2940

ttatcataat gcagatacat tttctgtgtt cagcaaggca ttgtgtgtca tgtggatctt   3000

agttaccaaa ctatgaagtg aaggctttaa aagtgcatta ttttaaggat aataaatttg   3060

aagagcaaag catgttttgt gtgtttgcca caaaacattg cttgaagcac atacttagat   3120

agaaattggt cttaatttat ataatcaata taaaatacta atgcaattct acagcattca   3180

aatgaagaaa acttgaggct ttagggataa gtggttagtg atattttatt gaaaccacta   3240

aagagataag tttaaaagaa ctgcataggt tactctcagt atatgatact ctgtaacatt   3300

tctatttata tcggcataaa tttcattttt tttcttcata tgcaatgtgg ttatataaag   3360

cttaatgcag ctcatttgct accatttgga tacttagaca ctttgagcaa gattgtggca   3420

gtttttgcac aactttgaaa tagaaatacc tggtactcta tcttgtttat tgttgatgcc   3480

atcttagagg aaaaaatgta aaggtaagta attaagcata tgacagcaac aaataagata   3540

cataaaacta caaaataaag tcccattagg ttataagtat tacaaaaaat ccacctttct   3600

ctaaggggaa gtttgtaccc cattgattct tggtgccttt gggatcgact gggttttaat   3660

ggcctagtta tttgaggatt ttgctgtgtt gttttccatg tcttctctgg tcaccttgga   3720

ttatatataa aaatacagga aatagataaa catgaatgtg attaataatg ctgaaaaagt   3780

attagcctac caaagacaca ctcaggcttt agtgaataac tttacataac ctcagttttt   3840

aacacatgca tatcttctcc aaccatgaaa tcaaagcacg gtgcagaact tgtaccaagt   3900

acaaaaggtc catgtatgat tagcattatt ttcttttgct tttgtttatg gacaatgttc   3960

agctgacata agcagaagtt ggccaaaata ctgcctgtac tgttaatttc ctgtataatt   4020

cacttaaata aaagcaggtt aacctcaatg atagcagtta aaatgttcta tcttatgtat   4080

ttcttttaag tattaccatt atggtgctac tgagcgtttt cttttggtaa aaagaaaaat   4140

gccatgggct gcagtcttct tccatcactt ttccctacca ggtccattaa tatgcttata   4200

acactagtgc cagttatttt atttgataat gcttatggta tttgtatatt tgtttgcatt   4260

ccaattttgt ttaataatga gtgtgtaaac tgcatacgtt aaataaatgt aaatactaat   4320

gtactgctgc aaaaaaaaaa aaaaaaaaaa aaaaaaa                            4357


<210>  1650
<211>  838
<212>  PRT
<213>  Homosapiens

<400>  1650

Met Gln Glu Gln Glu Ile Gly Phe Ile Ser Lys Tyr Asn Glu Gly Leu 
1               5                   10                  15      


Cys Val Asn Thr Asp Pro Val Ser Ile Leu Thr Ser Ile Leu Asp Met 
            20                  25                  30          


Ser Leu His Arg Gln Met Gly Ser Asp Arg Asp Leu Gln Ser Ser Ala 
        35                  40                  45              


Ser Ser Val Ser Leu Pro Ser Val Lys Lys Ala Pro Lys Lys Arg Arg 
    50                  55                  60                  


Ile Ser Ile Gly Ser Leu Phe Arg Arg Lys Lys Asp Asn Lys Arg Lys 
65                  70                  75                  80  


Ser Arg Glu Leu Asn Gly Gly Val Asp Gly Ile Ala Ser Ile Glu Ser 
                85                  90                  95      


Ile His Ser Glu Met Cys Thr Asp Lys Asn Ser Ile Phe Ser Thr Asn 
            100                 105                 110         


Thr Ser Ser Asp Asn Gly Leu Thr Ser Ile Ser Lys Gln Ile Gly Asp 
        115                 120                 125             


Phe Ile Glu Cys Pro Leu Cys Leu Leu Arg His Ser Lys Asp Arg Phe 
    130                 135                 140                 


Pro Asp Ile Met Thr Cys His His Arg Ser Cys Val Asp Cys Leu Arg 
145                 150                 155                 160 


Gln Tyr Leu Arg Ile Glu Ile Ser Glu Ser Arg Val Asn Ile Ser Cys 
                165                 170                 175     


Pro Glu Cys Thr Glu Arg Phe Asn Pro His Asp Ile Arg Leu Ile Leu 
            180                 185                 190         


Ser Asp Asp Val Leu Met Glu Lys Tyr Glu Glu Phe Met Leu Arg Arg 
        195                 200                 205             


Trp Leu Val Ala Asp Pro Asp Cys Arg Trp Cys Pro Ala Pro Asp Cys 
    210                 215                 220                 


Gly Tyr Ala Val Ile Ala Phe Gly Cys Ala Ser Cys Pro Lys Leu Thr 
225                 230                 235                 240 


Cys Gly Arg Glu Gly Cys Gly Thr Glu Phe Cys Tyr His Cys Lys Gln 
                245                 250                 255     


Ile Trp His Pro Asn Gln Thr Cys Asp Ala Ala Arg Gln Glu Arg Ala 
            260                 265                 270         


Gln Ser Leu Arg Leu Arg Thr Ile Arg Ser Ser Ser Ile Ser Tyr Ser 
        275                 280                 285             


Gln Glu Ser Gly Ala Ala Ala Asp Asp Ile Lys Pro Cys Pro Arg Cys 
    290                 295                 300                 


Ala Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His Met Thr 
305                 310                 315                 320 


Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys Glu Ile 
                325                 330                 335     


Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp Gly Lys 
            340                 345                 350         


Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly Thr Leu 
        355                 360                 365             


Val Gly Ala Pro Val Gly Ile Ala Leu Ile Ala Gly Ile Ala Ile Pro 
    370                 375                 380                 


Ala Met Ile Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile His Asn 
385                 390                 395                 400 


Arg Tyr Glu Gly Lys Asp Val Ser Lys His Lys Arg Asn Leu Ala Ile 
                405                 410                 415     


Ala Gly Gly Val Thr Leu Ser Val Ile Val Ser Pro Val Val Ala Ala 
            420                 425                 430         


Val Thr Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val Tyr Gly 
        435                 440                 445             


Val Val Pro Ile Ser Leu Cys Arg Ser Gly Gly Cys Gly Val Ser Ala 
    450                 455                 460                 


Gly Asn Gly Lys Gly Val Arg Ile Glu Phe Asp Asp Glu Asn Asp Ile 
465                 470                 475                 480 


Asn Val Gly Gly Thr Asn Thr Ala Val Asp Thr Thr Ser Val Ala Glu 
                485                 490                 495     


Ala Arg His Asn Pro Ser Ile Gly Glu Gly Ser Val Gly Gly Leu Thr 
            500                 505                 510         


Gly Ser Leu Ser Ala Ser Gly Ser His Met Asp Arg Ile Gly Ala Ile 
        515                 520                 525             


Arg Asp Asn Leu Ser Glu Thr Ala Ser Thr Met Ala Leu Ala Gly Ala 
    530                 535                 540                 


Ser Ile Thr Gly Ser Leu Ser Gly Ser Ala Met Val Asn Cys Phe Asn 
545                 550                 555                 560 


Arg Leu Glu Val Gln Ala Asp Val Gln Lys Glu Arg Tyr Ser Leu Ser 
                565                 570                 575     


Gly Glu Ser Gly Thr Val Ser Leu Gly Thr Val Ser Asp Asn Ala Ser 
            580                 585                 590         


Thr Lys Ala Met Ala Gly Ser Ile Leu Asn Ser Tyr Ile Pro Leu Asp 
        595                 600                 605             


Lys Glu Gly Asn Ser Met Glu Val Gln Val Asp Ile Glu Ser Lys Pro 
    610                 615                 620                 


Ser Lys Phe Arg His Asn Ser Gly Ser Ser Ser Val Asp Asp Gly Ser 
625                 630                 635                 640 


Ala Thr Arg Ser His Ala Gly Gly Ser Ser Ser Gly Leu Pro Glu Gly 
                645                 650                 655     


Lys Ser Ser Ala Thr Lys Trp Ser Lys Glu Ala Thr Ala Gly Lys Lys 
            660                 665                 670         


Ser Lys Ser Gly Lys Leu Arg Lys Lys Gly Asn Met Lys Ile Asn Glu 
        675                 680                 685             


Thr Arg Glu Asp Met Asp Ala Gln Leu Leu Glu Gln Gln Ser Thr Asn 
    690                 695                 700                 


Ser Ser Glu Phe Glu Ala Pro Ser Leu Ser Asp Ser Met Pro Ser Val 
705                 710                 715                 720 


Ala Asp Ser His Ser Ser His Phe Ser Glu Phe Ser Cys Ser Asp Leu 
                725                 730                 735     


Glu Ser Met Lys Thr Ser Cys Ser His Gly Ser Ser Asp Tyr His Thr 
            740                 745                 750         


Arg Phe Ala Thr Val Asn Ile Leu Pro Glu Val Glu Asn Asp Arg Leu 
        755                 760                 765             


Glu Asn Ser Pro His Gln Cys Ser Ile Ser Val Val Thr Gln Thr Ala 
    770                 775                 780                 


Ser Cys Ser Glu Val Ser Gln Leu Asn His Ile Ala Glu Glu His Gly 
785                 790                 795                 800 


Asn Asn Gly Ile Lys Pro Asn Val Asp Leu Tyr Phe Gly Asp Ala Leu 
                805                 810                 815     


Lys Glu Thr Asn Asn Asn His Ser His Gln Thr Met Glu Leu Lys Val 
            820                 825                 830         


Ala Ile Gln Thr Glu Ile 
        835             


<210>  1651
<211>  4366
<212>  DNA
<213>  Homosapiens

<400>  1651
ggtagttgcg gcgctggttc ccgggagcag ccgtcgagcc acaactgcgg aggaggagtt     60

cgggaaagcg gccgtcggga ctcctcccct ccgtcgtctc cgccccggtt gagaggcgcc    120

tcggcgcatc ggagggaccc tcccccgcgc ttcctcaggc tgctgtcgcc gctgctggga    180

gatgggccta ctcgcccgcc accctgcgct gccgccgctc tgaggagtta aagaacatcc    240

atgatagcag tcttctgtaa atcgaacttt tcaagaattc tctgaaggaa ccaagtagga    300

tattcttaca tcatgactta atgtgaatgc aagaacaaga aataggtttt atctctaaat    360

ataatgaagg gctgtgtgta aacactgacc ctgtctcaat tctaacaagc attttagaca    420

tgagtttaca tcggcaaatg ggttcagatc gagatcttca gtcctctgct tcatctgtga    480

gcttgccttc agtcaaaaag gcacccaaaa aaagaagaat ttcaataggc tccctgtttc    540

ggaggaaaaa agataacaaa cgtaaatcaa gggagctaaa tggcggggtg gatggaattg    600

caagtattga aagtatacat tctgaaatgt gtactgataa gaactccatt ttctctacaa    660

atacctcttc tgacaatgga ttaacttcca tcagcaaaca aattggagac ttcatagagt    720

gccctttgtg ccttttgcgg cattctaaag acagatttcc tgatataatg acttgtcatc    780

acagatcttg tgtggattgc ttacgacaat atttaaggat agaaatctct gaaagcagag    840

ttaatattag ttgcccagaa tgtactgaac ggtttaatcc ccatgatatt cgcttgatat    900

taagtgatga tgtcttgatg gaaaaatacg aagaatttat gcttagacgg tggcttgttg    960

cagatcctga ttgtaggtgg tgtccagctc cagactgtgg atatgctgtg atagcatttg   1020

gatgtgccag ctgtccaaaa ttaacttgtg ggcgagaggg ctgtggaaca gagttttgct   1080

accactgtaa acagatttgg caccccaacc agacctgtga tgctgctcga caagagagag   1140

cccagagctt acgtttgaga actatacgtt cttcatccat tagttatagt caagagtctg   1200

gagcagcagc tgatgatata aagccatgtc cacgatgtgc tgcttatata ataaagatga   1260

atgatgggag ctgcaatcac atgacatgtg ctgtttgtgg ttgtgagttt tgttggttgt   1320

gtatgaaaga aatctcagat ttgcattatc taagtccatc aggatgtact ttttggggga   1380

agaaaccctg gagccgaaag aagaaaatat tgtggcaact gggaacactg gttggtgctc   1440

ctgtcggaat cgctttaata gctggcattg ctattcctgc aatgattatt ggcattcctg   1500

tgtatgtggg ccgcaagatt cacaatcgct atgaaggcaa ggatgtttca aagcacaaac   1560

ggaatttggc catagcaggt ggtgtaacgt tgtctgtaat cgtgtctcca gtagtagctg   1620

cagtgactgt aggtatcggt gttcctatta tgttagctta tgtctatggc gtagttccaa   1680

tttctctttg tcgaagcgga ggttgtggag tctcagcagg caatggaaaa ggagttagga   1740

ttgaatttga tgatgaaaat gatataaatg ttggtggaac taacacagct gtagacacaa   1800

catcagtagc agaagcaaga cacaacccaa gcatagggga gggaagtgtt ggtgggctga   1860

ctggcagttt gagtgcaagt ggaagccaca tggatcgaat aggagccatc cgagacaacc   1920

tgagtgaaac ggccagcacc atggcactag ctggagccag tataacgggg agtctgtcag   1980

gaagtgccat ggtaaactgt tttaacaggt tggaagtaca agcagatgta cagaaagaac   2040

ggtacagtct aagtggagaa tctggcacag tcagcttggg aacagttagt gataatgcca   2100

gcaccaaagc aatggcagga tccattctga attcctacat cccattggac aaagaaggca   2160

acagtatgga ggtgcaagta gatattgagt caaagccatc caaattcagg cacaacagtg   2220

gaagcagtag tgtggatgat ggcagtgcca cccgaagtca tgctggcggt tcatccagtg   2280

gcttgcctga aggtaaatct agtgccacca agtggtccaa agaagcaaca gcagggaaaa   2340

aatcaaaaag tggtaaactg aggaaaaagg gtaacatgaa gataaatgag acgagagagg   2400

acatggatgc acagttgtta gaacaacaaa gcacgaactc aagtgaattt gaggctccat   2460

ccctcagtga cagtatgcct tctgtagcag attctcactc tagtcatttt tctgaattta   2520

gttgttctga cctagaaagc atgaaaactt cttgtagtca tggttccagt gattatcaca   2580

cccgctttgc tactgttaac attcttcctg aggtagaaaa tgaccgtctg gaaaattccc   2640

cacatcagtg tagcatttct gtggttaccc aaactgcttc ctgttcagaa gtttcacagt   2700

tgaatcatat tgctgaagaa catggtaaca atggaataaa acctaatgtt gatttatatt   2760

ttggcgatgc actaaaagaa acaaataaca accactcaca tcagacaatg gaattaaaag   2820

ttgcaattca gactgaaatt taggcccata aatgctgcag aataattacc actgtacaac   2880

cgtgtttgga gctggttgaa ctacatgtga ctacttaagt ttcaggttac cagcaaaagc   2940

cgggtttcat tatcataatg cagatacatt ttctgtgttc agcaaggcat tgtgtgtcat   3000

gtggatctta gttaccaaac tatgaagtga aggctttaaa agtgcattat tttaaggata   3060

ataaatttga agagcaaagc atgttttgtg tgtttgccac aaaacattgc ttgaagcaca   3120

tacttagata gaaattggtc ttaatttata taatcaatat aaaatactaa tgcaattcta   3180

cagcattcaa atgaagaaaa cttgaggctt tagggataag tggttagtga tattttattg   3240

aaaccactaa agagataagt ttaaaagaac tgcataggtt actctcagta tatgatactc   3300

tgtaacattt ctatttatat cggcataaat ttcatttttt ttcttcatat gcaatgtggt   3360

tatataaagc ttaatgcagc tcatttgcta ccatttggat acttagacac tttgagcaag   3420

attgtggcag tttttgcaca actttgaaat agaaatacct ggtactctat cttgtttatt   3480

gttgatgcca tcttagagga aaaaatgtaa aggtaagtaa ttaagcatat gacagcaaca   3540

aataagatac ataaaactac aaaataaagt cccattaggt tataagtatt acaaaaaatc   3600

cacctttctc taaggggaag tttgtacccc attgattctt ggtgcctttg ggatcgactg   3660

ggttttaatg gcctagttat ttgaggattt tgctgtgttg ttttccatgt cttctctggt   3720

caccttggat tatatataaa aatacaggaa atagataaac atgaatgtga ttaataatgc   3780

tgaaaaagta ttagcctacc aaagacacac tcaggcttta gtgaataact ttacataacc   3840

tcagttttta acacatgcat atcttctcca accatgaaat caaagcacgg tgcagaactt   3900

gtaccaagta caaaaggtcc atgtatgatt agcattattt tcttttgctt ttgtttatgg   3960

acaatgttca gctgacataa gcagaagttg gccaaaatac tgcctgtact gttaatttcc   4020

tgtataattc acttaaataa aagcaggtta acctcaatga tagcagttaa aatgttctat   4080

cttatgtatt tcttttaagt attaccatta tggtgctact gagcgttttc ttttggtaaa   4140

aagaaaaatg ccatgggctg cagtcttctt ccatcacttt tccctaccag gtccattaat   4200

atgcttataa cactagtgcc agttatttta tttgataatg cttatggtat ttgtatattt   4260

gtttgcattc caattttgtt taataatgag tgtgtaaact gcatacgtta aataaatgta   4320

aatactaatg tactgctgca aaaaaaaaaa aaaaaaaaaa aaaaaa                  4366


<210>  1652
<211>  838
<212>  PRT
<213>  Homosapiens

<400>  1652

Met Gln Glu Gln Glu Ile Gly Phe Ile Ser Lys Tyr Asn Glu Gly Leu 
1               5                   10                  15      


Cys Val Asn Thr Asp Pro Val Ser Ile Leu Thr Ser Ile Leu Asp Met 
            20                  25                  30          


Ser Leu His Arg Gln Met Gly Ser Asp Arg Asp Leu Gln Ser Ser Ala 
        35                  40                  45              


Ser Ser Val Ser Leu Pro Ser Val Lys Lys Ala Pro Lys Lys Arg Arg 
    50                  55                  60                  


Ile Ser Ile Gly Ser Leu Phe Arg Arg Lys Lys Asp Asn Lys Arg Lys 
65                  70                  75                  80  


Ser Arg Glu Leu Asn Gly Gly Val Asp Gly Ile Ala Ser Ile Glu Ser 
                85                  90                  95      


Ile His Ser Glu Met Cys Thr Asp Lys Asn Ser Ile Phe Ser Thr Asn 
            100                 105                 110         


Thr Ser Ser Asp Asn Gly Leu Thr Ser Ile Ser Lys Gln Ile Gly Asp 
        115                 120                 125             


Phe Ile Glu Cys Pro Leu Cys Leu Leu Arg His Ser Lys Asp Arg Phe 
    130                 135                 140                 


Pro Asp Ile Met Thr Cys His His Arg Ser Cys Val Asp Cys Leu Arg 
145                 150                 155                 160 


Gln Tyr Leu Arg Ile Glu Ile Ser Glu Ser Arg Val Asn Ile Ser Cys 
                165                 170                 175     


Pro Glu Cys Thr Glu Arg Phe Asn Pro His Asp Ile Arg Leu Ile Leu 
            180                 185                 190         


Ser Asp Asp Val Leu Met Glu Lys Tyr Glu Glu Phe Met Leu Arg Arg 
        195                 200                 205             


Trp Leu Val Ala Asp Pro Asp Cys Arg Trp Cys Pro Ala Pro Asp Cys 
    210                 215                 220                 


Gly Tyr Ala Val Ile Ala Phe Gly Cys Ala Ser Cys Pro Lys Leu Thr 
225                 230                 235                 240 


Cys Gly Arg Glu Gly Cys Gly Thr Glu Phe Cys Tyr His Cys Lys Gln 
                245                 250                 255     


Ile Trp His Pro Asn Gln Thr Cys Asp Ala Ala Arg Gln Glu Arg Ala 
            260                 265                 270         


Gln Ser Leu Arg Leu Arg Thr Ile Arg Ser Ser Ser Ile Ser Tyr Ser 
        275                 280                 285             


Gln Glu Ser Gly Ala Ala Ala Asp Asp Ile Lys Pro Cys Pro Arg Cys 
    290                 295                 300                 


Ala Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His Met Thr 
305                 310                 315                 320 


Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys Glu Ile 
                325                 330                 335     


Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp Gly Lys 
            340                 345                 350         


Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly Thr Leu 
        355                 360                 365             


Val Gly Ala Pro Val Gly Ile Ala Leu Ile Ala Gly Ile Ala Ile Pro 
    370                 375                 380                 


Ala Met Ile Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile His Asn 
385                 390                 395                 400 


Arg Tyr Glu Gly Lys Asp Val Ser Lys His Lys Arg Asn Leu Ala Ile 
                405                 410                 415     


Ala Gly Gly Val Thr Leu Ser Val Ile Val Ser Pro Val Val Ala Ala 
            420                 425                 430         


Val Thr Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val Tyr Gly 
        435                 440                 445             


Val Val Pro Ile Ser Leu Cys Arg Ser Gly Gly Cys Gly Val Ser Ala 
    450                 455                 460                 


Gly Asn Gly Lys Gly Val Arg Ile Glu Phe Asp Asp Glu Asn Asp Ile 
465                 470                 475                 480 


Asn Val Gly Gly Thr Asn Thr Ala Val Asp Thr Thr Ser Val Ala Glu 
                485                 490                 495     


Ala Arg His Asn Pro Ser Ile Gly Glu Gly Ser Val Gly Gly Leu Thr 
            500                 505                 510         


Gly Ser Leu Ser Ala Ser Gly Ser His Met Asp Arg Ile Gly Ala Ile 
        515                 520                 525             


Arg Asp Asn Leu Ser Glu Thr Ala Ser Thr Met Ala Leu Ala Gly Ala 
    530                 535                 540                 


Ser Ile Thr Gly Ser Leu Ser Gly Ser Ala Met Val Asn Cys Phe Asn 
545                 550                 555                 560 


Arg Leu Glu Val Gln Ala Asp Val Gln Lys Glu Arg Tyr Ser Leu Ser 
                565                 570                 575     


Gly Glu Ser Gly Thr Val Ser Leu Gly Thr Val Ser Asp Asn Ala Ser 
            580                 585                 590         


Thr Lys Ala Met Ala Gly Ser Ile Leu Asn Ser Tyr Ile Pro Leu Asp 
        595                 600                 605             


Lys Glu Gly Asn Ser Met Glu Val Gln Val Asp Ile Glu Ser Lys Pro 
    610                 615                 620                 


Ser Lys Phe Arg His Asn Ser Gly Ser Ser Ser Val Asp Asp Gly Ser 
625                 630                 635                 640 


Ala Thr Arg Ser His Ala Gly Gly Ser Ser Ser Gly Leu Pro Glu Gly 
                645                 650                 655     


Lys Ser Ser Ala Thr Lys Trp Ser Lys Glu Ala Thr Ala Gly Lys Lys 
            660                 665                 670         


Ser Lys Ser Gly Lys Leu Arg Lys Lys Gly Asn Met Lys Ile Asn Glu 
        675                 680                 685             


Thr Arg Glu Asp Met Asp Ala Gln Leu Leu Glu Gln Gln Ser Thr Asn 
    690                 695                 700                 


Ser Ser Glu Phe Glu Ala Pro Ser Leu Ser Asp Ser Met Pro Ser Val 
705                 710                 715                 720 


Ala Asp Ser His Ser Ser His Phe Ser Glu Phe Ser Cys Ser Asp Leu 
                725                 730                 735     


Glu Ser Met Lys Thr Ser Cys Ser His Gly Ser Ser Asp Tyr His Thr 
            740                 745                 750         


Arg Phe Ala Thr Val Asn Ile Leu Pro Glu Val Glu Asn Asp Arg Leu 
        755                 760                 765             


Glu Asn Ser Pro His Gln Cys Ser Ile Ser Val Val Thr Gln Thr Ala 
    770                 775                 780                 


Ser Cys Ser Glu Val Ser Gln Leu Asn His Ile Ala Glu Glu His Gly 
785                 790                 795                 800 


Asn Asn Gly Ile Lys Pro Asn Val Asp Leu Tyr Phe Gly Asp Ala Leu 
                805                 810                 815     


Lys Glu Thr Asn Asn Asn His Ser His Gln Thr Met Glu Leu Lys Val 
            820                 825                 830         


Ala Ile Gln Thr Glu Ile 
        835             


<210>  1653
<211>  2842
<212>  DNA
<213>  Homosapiens

<400>  1653
tggaattcca gagctgccag gcgctcccag ccggtctcgg caaacttttc cccagcccac     60

gtgctaacca agcggctctc ttcccgagcc cgggatggag caccgcgcct agggaggccg    120

cgccgcccga gacgtgcgca cggttcgtgg cggagagatg ctgatcgcgc tgaactgacc    180

ggtgcggccc gggggtgagt ggcgagtctc cctctgagtc ctccccagca gcgcggccgg    240

cgccggctct ttgggcgaac cctccagttc ctagactttg agaggcgtct ctcccccgcc    300

cgaccgccca gatgcagttt cgccttttct cctttgccct catcattctg aactgcatgg    360

attacagcca ctgccaaggc aaccgatgga gacgcagtaa gcgagctagt tatgtatcaa    420

atcccatttg caagggttgt ttgtcttgtt caaaggacaa tgggtgtagc cgatgtcaac    480

agaagttgtt cttcttcctt cgaagagaag ggatgcgcca gtatggagag tgcctgcatt    540

cctgcccatc cgggtactat ggacaccgag ccccagatat gaacagatgt gcaagatgca    600

gaatagaaaa ctgtgattct tgctttagca aagacttttg taccaagtgc aaagtaggct    660

tttatttgca tagaggccgt tgctttgatg aatgtccaga tggttttgca ccattagaag    720

aaaccatgga atgtgtggaa ggatgtgaag ttggtcattg gagcgaatgg ggaacttgta    780

gcagaaataa tcgcacatgt ggatttaaat ggggtctgga aaccagaaca cggcaaattg    840

ttaaaaagcc agtgaaagac acaataccgt gtccaaccat tgctgaatcc aggagatgca    900

agatgacaat gaggcattgt ccaggaggga agagaacacc aaaggcgaag gagaagagga    960

acaagaaaaa gaaaaggaag ctgatagaaa gggcccagga gcaacacagc gtcttcctag   1020

ctacagacag agctaaccaa taaaacaaga gatccggtag atttttaggg gtttttgttt   1080

ttgcaaatgt gcacaaagct actctccact cctgcacact ggtgtgcagc ctttgtgctg   1140

ctctgcccag tatctgttcc cagtaacatg gtgaaaggaa gcaccaccag catggcccct   1200

gtgttattta tgctttgatt tgaatctgga gactgtgaag gcaggagtaa gtgcacagcc   1260

cgtgacttgg ctcagtgtgt gctgagagaa tccgtccccg gcaccatgga catgctagag   1320

gtgtgaggct gcagaacacc gctggaggac ggacttgtgc ctatttatgt gaaagaagat   1380

gcttggcagg caatgcgcta ctcactcgtg acctttattt ctcacattgt gcattttcaa   1440

ggatatgttt gtgtggatat ctgcttagtg ttaccacatg gtattctcag catgttacct   1500

tcacactgtt gtgcgatgaa actgctttta gctgaggata tgctctggaa attcctgctc   1560

agtttcactg cagccctaat atgtacatat actgcaggag ctacatataa agctcttatt   1620

tactgtatat ttatgctttc ttgtgggtaa caagtcatac ctgattaata tgatgccact   1680

ttgtttctag tggttcctaa cccattgtct gataaatgac ttttctagtt tggggaattg   1740

acacttgttt tgttgcctct tgaaactttt tttttttccc ctcattgtgg gcttatttct   1800

cattgtaagg gtaggataaa ctagtttttg tatatagagt caaatgacca gtgtcaaaga   1860

gtttgcatat tgggtagacc ttctccactc cacatgtccc acacatatag ataaagcagc   1920

aggcggcatc tggcaatcag aagcccaaac tgcctttgag tctaagatgt gatgactttg   1980

atgaaacaca actgaaaaca tgagggacta tatccagtca cttgtagcca gtttcacagg   2040

ccagctacag aattgtccaa acaaacatta tttctgactg caattttttt cccccaaatt   2100

taaagcaatc cctggcttta aatgacaagg cacctaccaa tgttcttggg tcactgaaga   2160

agctactacc atgagcctgt gcatagaatt ttaggagata aaaggatgaa tttctgtgac   2220

tgccagtcag atcttaacag gtttctgttg agccagaatc tgtttcagat ccaagatgga   2280

gaggaacact atggaaactt cccaggtgac tttcagagca gttgtttcaa acacatcatt   2340

gtccttttag gggaaccagt ttttagaagg ttgtgaattg gctttttcac aaagcatgat   2400

tatcttcctg gctgatccag gagaaaatta gaacagaaaa ataatggttg tggattttga   2460

aacaaagcaa ggtaaagcct tttttttttc accttgcatt ggcaaaacta cctcttcagt   2520

gtttttaact tttgattcaa aagcatctta ccaataagga taaatatcat atacatcgtt   2580

atgaaaatat tgctatgaga taataagcca catatgaatg ttgtatacaa ctttagggtt   2640

tacatttaat cctgaagtgt tacctccttt catgtctatt tacactattt tcccatttac   2700

taagtgggga gggggtctcc ttatatagtg cttcatcgtt aataagtcaa tacctgttgt   2760

tcctgggatg ttcttttttg tgcattaaaa acttcaaaat taaaaaaaaa aaaaaaaaaa   2820

aaaaaaaaaa aaaaaaaaaa ag                                            2842


<210>  1654
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  1654

Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met 
1               5                   10                  15      


Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala 
            20                  25                  30          


Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys 
        35                  40                  45              


Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg 
    50                  55                  60                  


Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser 
65                  70                  75                  80  


Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys 
                85                  90                  95      


Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys 
            100                 105                 110         


Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys 
        115                 120                 125             


Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr Met Glu Cys Val Glu Gly 
    130                 135                 140                 


Cys Glu Val Gly His Trp Ser Glu Trp Gly Thr Cys Ser Arg Asn Asn 
145                 150                 155                 160 


Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu Thr Arg Thr Arg Gln Ile 
                165                 170                 175     


Val Lys Lys Pro Val Lys Asp Thr Ile Pro Cys Pro Thr Ile Ala Glu 
            180                 185                 190         


Ser Arg Arg Cys Lys Met Thr Met Arg His Cys Pro Gly Gly Lys Arg 
        195                 200                 205             


Thr Pro Lys Ala Lys Glu Lys Arg Asn Lys Lys Lys Lys Arg Lys Leu 
    210                 215                 220                 


Ile Glu Arg Ala Gln Glu Gln His Ser Val Phe Leu Ala Thr Asp Arg 
225                 230                 235                 240 


Ala Asn Gln 
            


<210>  1655
<211>  6463
<212>  DNA
<213>  Homosapiens

<400>  1655
atcctgggct cccagctgga gaggcggagg cagctccagg gggctggaag tggaagcgca     60

gcggcagaag gagagggaga gagaaagaga gagaggctaa ttaaaaaagg atactccgag    120

ggaagagagc aagggcggtg cgccgccaag gaccaactag cggcggagct tcgatcttgc    180

ctaggcgcgg agagctccca acctgggctg gaaccttgcc cagcacaggt ggctgctaca    240

ccccatgtaa aaagcggaaa ataaaatgaa gattttccag cgcaagatgc ggtactggtt    300

gcttccacct tttttggcaa ttgtttattt ctgcaccatt gtccaaggtc aagtggctcc    360

acccacaagg ttaagatata atgtaatatc tcatgacagt atacagattt catggaaggc    420

tccaagaggg aaatttggtg gttacaaact tcttgtgact ccaacttcag gtggaaaaac    480

taaccagctg aatctgcaga acactgcaac taaagcaatt attcaaggcc ttatgccaga    540

ccagaattac acagttcaaa ttattgcata caataaagat aaagaaagca agccagctca    600

aggccaattc agaattaaag atttagaaaa aagaaaggat ccaaagccca gagtcaaagt    660

tgtggacaga ggaaatggga gtagaccatc ttcaccagaa gaagtgaaat ttgtctgtca    720

aactccagca attgctgaca ttgtaatcct ggtcgatggt tcatggagta ttggaagatt    780

caacttcaga ctggttcggc atttcttgga aaacctggtt acagcattcg atgtgggctc    840

agagaagaca cgaattggtc ttgcacagta tagtggtgac cccagaatag aatggcactt    900

gaatgcattt agcacaaaag atgaagtgat tgaagctgtc cgaaacctcc catataaagg    960

aggaaataca ctaacaggtc ttgctttgaa ctacattttt gaaaatagct tcaaaccaga   1020

agcaggatca aggactggag tatccaaaat tggcatttta atcacagatg gaaaatccca   1080

agatgacatt attccaccat ctagaaatct tcgtgagtct ggtgtagaac tgtttgccat   1140

aggggtgaaa aacgcggatg tgaatgagct gcaggagatc gcctctgaac cagacagcac   1200

tcatgtgtac aatgttgccg aattcgatct gatgcacaca gttgtggaga gtctgaccag   1260

gactctctgc tctagagtgg aagaacagga cagagaaatt aaagcctcag cccatgccat   1320

cactgggccg cctacggagt tgattacttc tgaagtcact gccagaagct ttatggttaa   1380

ctggactcat gccccaggaa atgtggaaaa atacagagtt gtgtattatc ctaccagggg   1440

tggaaaacca gacgaggtgg tggtagatgg aactgtatct tccacagtgt tgaaaaactt   1500

gatgtcttta actgaatatc agatagcagt ctttgcaatc tatgcccaca ctgctagtga   1560

aggcctacgg ggaactgaaa ctacacttgc tttaccgatg gcttctgacc ttctactgta   1620

cgacgtgact gagaacagca tgcgagtcaa atgggatgca gtgcctgggg cctcaggtta   1680

cctgatcctt tatgctcctc taacagaggg cctggctggg gatgaaaaag agatgaaaat   1740

tggagagacc cacacagata ttgaattgag tgggttgttg cccaatacag aatacacagt   1800

cacagtttat gccatgtttg gagaagaggc cagtgatcct gttacgggac aagaaacaac   1860

attggcttta agtccaccaa gaaacctgag aatctccaat gttggctcta acagtgctcg   1920

attaacctgg gacccaactt caagacagat caatggttat cgaattgtat ataacaatgc   1980

agatgggact gaaatcaatg aggttgaagt cgatcctatt actaccttcc ctctgaaggg   2040

cttgacacct ctcacagagt atactattgc tattttctcc atctatgatg aaggacagtc   2100

agagcctctg actggagttt ttaccaccga ggaagttcca gcccagcaat acttagaaat   2160

tgatgaggtg acgacagaca gttttagggt gacctggcat cccctctcag ctgatgaagg   2220

gctacacaaa ttgatgtgga ttccagtcta tggggggaag actgaggagg ttgtcctgaa   2280

agaagagcag gactcacatg ttattgaagg cctggagccc ggtacggagt atgaagtttc   2340

actattggcc gtacttgatg atggaagcga gagtgaggtg gtgactgctg tcgggaccac   2400

acttgacagt ttttggacag aaccagctac aaccatagtg cctaccacat ctgtgacttc   2460

agttttccag acgggaatca gaaacctagt tgtaggtgat gaaactactt ctagcctgcg   2520

ggtaaaatgg gacatttctg acagcgatgt gcagcagttt agggtgacct acatgacagc   2580

tcaaggggac cctgaggaag aagtcatagg aacggttatg gtgcctggaa gccagaacaa   2640

cctccttctg aagcctctgc ttcctgatac tgaatacaaa gtcacagtga ctcccatcta   2700

cacggatggc gaaggcgtca gcgtctccgc tcctggaaaa accttaccat cctcggggcc   2760

ccagaacttg cgggtgtccg aggaatggta taaccggttg cgcattacgt gggacccccc   2820

atcttccccg gtgaaaggct atagaattgt ctacaaacct gtcagtgttc ctggtccaac   2880

actggaaacg tttgtgggag ctgacattaa caccatcctt atcacaaacc tcctcagcgg   2940

aatggactac aatgtgaaga tatttgcctc ccaggcctca ggcttcagcg acgccctgac   3000

aggcatggtg aaaacattgt tcttgggtgt taccaatctc caagccaaac atgttgaaat   3060

gaccagcttg tgtgcccact ggcaggtaca tcgccatgcc acagcctata gggttgttat   3120

agaatccctc caggataggc aaaagcaaga atccactgtg ggtggaggga caaccaggca   3180

ttgcttctat ggacttcagc ctgattctga atataaaatc agtgtttata caaagctcca   3240

ggagattgaa ggacctagtg tgagcataat ggaaaaaaca caatcacttc ctacacgacc   3300

accaactttt cctccaacca ttccaccagc aaaagaagta tgtaaggcgg ccaaggctga   3360

cctggtattt atggtggatg gatcctggag cattggagat gaaaatttca ataagatcat   3420

cagctttcta tacagcactg ttggagccct gaacaagatt ggcacagatg gaacccaagt   3480

tgcaatggtt cagttcactg atgatcccag aacagaattt aaactaaatg cttacaaaac   3540

caaagagact cttcttgatg caattaaaca catttcatac aaaggaggaa atacaaaaac   3600

aggaaaagca attaagtatg ttcgagatac cttgttcact gcagagtcag gtacaagaag   3660

gggcatccca aaggttatcg tggttataac tgatggaaga tcacaagatg atgtgaacaa   3720

aatctccagg gagatgcaat tagatggcta tagcattttt gcaattggtg tggccgatgc   3780

agattactcg gagttggtta gcattggcag taagcccagc gcacgccatg tcttctttgt   3840

ggatgacttt gacgccttta agaaaatcga agatgagtta attacttttg tctgcgaaac   3900

agcatcagca acctgtccag tggtacacaa ggatggcatt gatcttgcag gatttaagat   3960

gatggaaatg tttggtttgg ttgaaaaaga tttttcatca gtggaagggg tttctatgga   4020

gcctggtacc ttcaatgtgt ttccatgtta ccaactccat aaagatgccc tggtttccca   4080

gccaaccagg tacttgcacc cagaaggatt gccctccgac tacacaatca gttttctatt   4140

ccggattctt cctgacactc cacaggagcc atttgctctt tgggagattt taaataaaaa   4200

ttctgaccca ttggttgggg ttattttaga caatggtggg aaaactctaa catatttcaa   4260

ctatgaccag agtggggatt ttcaaactgt tactttcgaa ggacctgaaa ttaggaaaat   4320

tttttatgga agctttcaca agctacacat tgttgtcagt gagactttgg tcaaagtggt   4380

tattgactgc aagcaagtgg gtgagaaggc aatgaacgca tcagctaata tcacgtcaga   4440

tggtgtagaa gtgctaggga aaatggttcg atcaagagga ccaggtggaa actctgcacc   4500

gttccagtta cagatgtttg atattgtttg ctccacatca tgggccaata cagacaaatg   4560

ctgtgaactt ccaggcctga gagatgatga gtcttgccca gaccttcccc attcctgctc   4620

ctgttctgaa accaatgaag tggctctggg accagcgggc ccaccaggtg gtccaggact   4680

ccgaggacca aagggccagc aaggtgaacc gggtccaaag ggaccagatg gccctcgggg   4740

tgaaattggt ctgccaggac ctcagggtcc acctggacct caaggaccaa gtggtctgtc   4800

cattcaagga atgcccggaa tgccaggaga aaaaggagag aaaggagata ctggccttcc   4860

aggtccacag ggtatcccag gaggcgttgg ttcaccagga cgtgatggct caccaggcca   4920

gaggggcctt ccgggaaagg atggatcctc gggacctcca ggaccaccag ggccaatagg   4980

cattcctggc acccctggag tcccagggat cacaggaagc atgggaccgc aaggcgccct   5040

gggaccacct ggtgtccctg gagcaaaggg ggaacgagga gagcggggtg acctgcagtc   5100

tcaagccatg gtgagatcag tggcgcgtca agtatgcgaa cagctcatcc agagtcacat   5160

ggccaggtac actgccatcc tcaaccagat tcccagccac tcctcatcca tccggactgt   5220

ccaagggcct cctggggagc ctgggaggcc aggctcacct ggagcccctg gtgaacaagg   5280

acccccaggc acaccaggct tccccggaaa tgcaggcgtg ccagggaccc caggagaacg   5340

aggtctaact ggtatcaaag gagaaaaagg aaatccaggc gttggaaccc aaggtccaag   5400

aggcccccct ggaccagcag gaccttcagg ggagagtcgg cctggcagcc ctgggccccc   5460

tggctctcct ggaccaagag gcccaccagg tcatctgggg gttcctggac cccaaggtcc   5520

ttctggccag cctggatatt gtgacccctc atcatgttct gcctatggtg tgagagctcc   5580

ccatccagat cagccagagt tcacccctgt ccaagatgag ctggaagcca tggaactgtg   5640

gggccctgga gtctgatagc ctcaggagaa atttgaagac caactgcaag aactcttaag   5700

gaatcttgtt tgagaaaatg ttgttatgtg gtttgtatgc tacttttggg gggcagggct   5760

catttcagca gcctaaatct cctccttgga taatgttaat attattatta ttattaacaa   5820

aaaatatata tttttaaaaa gttcccttaa tctatgacat ggtagcaatg atttcccttt   5880

ggtgtcttaa tggcatgtca gataatttgt ttttccagag aagagagctc aaagaggaat   5940

tgggaaaaat aaattgaact ctggaatctt ctctctcaag tcctaaaatg aacaaacaga   6000

tatgattgtg tttgagggaa atatgtccct agcaggaaaa gaattcaaag aggttcaaag   6060

aatatgtcac ttactcctac ttgctgtagg aataaccttg ctgataagaa aaaaagggac   6120

aatattggag aaactacctc ttgtttaatt gatctgtcca actctgagat cacttggtaa   6180

ctggtttcat gtgtatccaa aaatcagcat ttggatttaa gctttctgaa tttggtagtt   6240

taagaaacag atttagtttt tcaatggttt taactcatgt gaaataatga ttttccacca   6300

gctctgatgc aaagagatat aattttaatg aacgatttat ccagcagtgt gttccagggg   6360

ttgcctctcc ttatctacgg ggattacttt gtacatgcag ataagttttc gcaaacctat   6420

ttccattttc ttttgtaagc aaataaaact ttaaaacaaa aaa                     6463


<210>  1656
<211>  1796
<212>  PRT
<213>  Homosapiens

<400>  1656

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser 
    530                 535                 540                 


Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg 
545                 550                 555                 560 


Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu 
                565                 570                 575     


Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr Phe Pro Leu Lys Gly 
            580                 585                 590         


Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile Phe Ser Ile Tyr Asp 
        595                 600                 605             


Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe Thr Thr Glu Glu Val 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val Thr Thr Asp Ser Phe 
625                 630                 635                 640 


Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu Gly Leu His Lys Leu 
                645                 650                 655     


Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu Glu Val Val Leu Lys 
            660                 665                 670         


Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu Glu Pro Gly Thr Glu 
        675                 680                 685             


Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp Gly Ser Glu Ser Glu 
    690                 695                 700                 


Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser Phe Trp Thr Glu Pro 
705                 710                 715                 720 


Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr Ser Val Phe Gln Thr 
                725                 730                 735     


Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr Thr Ser Ser Leu Arg 
            740                 745                 750         


Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln Gln Phe Arg Val Thr 
        755                 760                 765             


Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu Val Ile Gly Thr Val 
    770                 775                 780                 


Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu Lys Pro Leu Leu Pro 
785                 790                 795                 800 


Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile Tyr Thr Asp Gly Glu 
                805                 810                 815     


Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu Pro Ser Ser Gly Pro 
            820                 825                 830         


Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn Arg Leu Arg Ile Thr 
        835                 840                 845             


Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr Arg Ile Val Tyr Lys 
    850                 855                 860                 


Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr Phe Val Gly Ala Asp 
865                 870                 875                 880 


Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser Gly Met Asp Tyr Asn 
                885                 890                 895     


Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe Ser Asp Ala Leu Thr 
            900                 905                 910         


Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr Asn Leu Gln Ala Lys 
        915                 920                 925             


His Val Glu Met Thr Ser Leu Cys Ala His Trp Gln Val His Arg His 
    930                 935                 940                 


Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu Gln Asp Arg Gln Lys 
945                 950                 955                 960 


Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg His Cys Phe Tyr Gly 
                965                 970                 975     


Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val Tyr Thr Lys Leu Gln 
            980                 985                 990         


Glu Ile Glu Gly Pro Ser Val Ser  Ile Met Glu Lys Thr  Gln Ser Leu 
        995                 1000                 1005             


Pro Thr  Arg Pro Pro Thr Phe  Pro Pro Thr Ile Pro  Pro Ala Lys 
    1010                 1015                 1020             


Glu Val  Cys Lys Ala Ala Lys  Ala Asp Leu Val Phe  Met Val Asp 
    1025                 1030                 1035             


Gly Ser  Trp Ser Ile Gly Asp  Glu Asn Phe Asn Lys  Ile Ile Ser 
    1040                 1045                 1050             


Phe Leu  Tyr Ser Thr Val Gly  Ala Leu Asn Lys Ile  Gly Thr Asp 
    1055                 1060                 1065             


Gly Thr  Gln Val Ala Met Val  Gln Phe Thr Asp Asp  Pro Arg Thr 
    1070                 1075                 1080             


Glu Phe  Lys Leu Asn Ala Tyr  Lys Thr Lys Glu Thr  Leu Leu Asp 
    1085                 1090                 1095             


Ala Ile  Lys His Ile Ser Tyr  Lys Gly Gly Asn Thr  Lys Thr Gly 
    1100                 1105                 1110             


Lys Ala  Ile Lys Tyr Val Arg  Asp Thr Leu Phe Thr  Ala Glu Ser 
    1115                 1120                 1125             


Gly Thr  Arg Arg Gly Ile Pro  Lys Val Ile Val Val  Ile Thr Asp 
    1130                 1135                 1140             


Gly Arg  Ser Gln Asp Asp Val  Asn Lys Ile Ser Arg  Glu Met Gln 
    1145                 1150                 1155             


Leu Asp  Gly Tyr Ser Ile Phe  Ala Ile Gly Val Ala  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Ser  Glu Leu Val Ser Ile  Gly Ser Lys Pro Ser  Ala Arg His 
    1175                 1180                 1185             


Val Phe  Phe Val Asp Asp Phe  Asp Ala Phe Lys Lys  Ile Glu Asp 
    1190                 1195                 1200             


Glu Leu  Ile Thr Phe Val Cys  Glu Thr Ala Ser Ala  Thr Cys Pro 
    1205                 1210                 1215             


Val Val  His Lys Asp Gly Ile  Asp Leu Ala Gly Phe  Lys Met Met 
    1220                 1225                 1230             


Glu Met  Phe Gly Leu Val Glu  Lys Asp Phe Ser Ser  Val Glu Gly 
    1235                 1240                 1245             


Val Ser  Met Glu Pro Gly Thr  Phe Asn Val Phe Pro  Cys Tyr Gln 
    1250                 1255                 1260             


Leu His  Lys Asp Ala Leu Val  Ser Gln Pro Thr Arg  Tyr Leu His 
    1265                 1270                 1275             


Pro Glu  Gly Leu Pro Ser Asp  Tyr Thr Ile Ser Phe  Leu Phe Arg 
    1280                 1285                 1290             


Ile Leu  Pro Asp Thr Pro Gln  Glu Pro Phe Ala Leu  Trp Glu Ile 
    1295                 1300                 1305             


Leu Asn  Lys Asn Ser Asp Pro  Leu Val Gly Val Ile  Leu Asp Asn 
    1310                 1315                 1320             


Gly Gly  Lys Thr Leu Thr Tyr  Phe Asn Tyr Asp Gln  Ser Gly Asp 
    1325                 1330                 1335             


Phe Gln  Thr Val Thr Phe Glu  Gly Pro Glu Ile Arg  Lys Ile Phe 
    1340                 1345                 1350             


Tyr Gly  Ser Phe His Lys Leu  His Ile Val Val Ser  Glu Thr Leu 
    1355                 1360                 1365             


Val Lys  Val Val Ile Asp Cys  Lys Gln Val Gly Glu  Lys Ala Met 
    1370                 1375                 1380             


Asn Ala  Ser Ala Asn Ile Thr  Ser Asp Gly Val Glu  Val Leu Gly 
    1385                 1390                 1395             


Lys Met  Val Arg Ser Arg Gly  Pro Gly Gly Asn Ser  Ala Pro Phe 
    1400                 1405                 1410             


Gln Leu  Gln Met Phe Asp Ile  Val Cys Ser Thr Ser  Trp Ala Asn 
    1415                 1420                 1425             


Thr Asp  Lys Cys Cys Glu Leu  Pro Gly Leu Arg Asp  Asp Glu Ser 
    1430                 1435                 1440             


Cys Pro  Asp Leu Pro His Ser  Cys Ser Cys Ser Glu  Thr Asn Glu 
    1445                 1450                 1455             


Val Ala  Leu Gly Pro Ala Gly  Pro Pro Gly Gly Pro  Gly Leu Arg 
    1460                 1465                 1470             


Gly Pro  Lys Gly Gln Gln Gly  Glu Pro Gly Pro Lys  Gly Pro Asp 
    1475                 1480                 1485             


Gly Pro  Arg Gly Glu Ile Gly  Leu Pro Gly Pro Gln  Gly Pro Pro 
    1490                 1495                 1500             


Gly Pro  Gln Gly Pro Ser Gly  Leu Ser Ile Gln Gly  Met Pro Gly 
    1505                 1510                 1515             


Met Pro  Gly Glu Lys Gly Glu  Lys Gly Asp Thr Gly  Leu Pro Gly 
    1520                 1525                 1530             


Pro Gln  Gly Ile Pro Gly Gly  Val Gly Ser Pro Gly  Arg Asp Gly 
    1535                 1540                 1545             


Ser Pro  Gly Gln Arg Gly Leu  Pro Gly Lys Asp Gly  Ser Ser Gly 
    1550                 1555                 1560             


Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Ile Pro Gly  Thr Pro Gly 
    1565                 1570                 1575             


Val Pro  Gly Ile Thr Gly Ser  Met Gly Pro Gln Gly  Ala Leu Gly 
    1580                 1585                 1590             


Pro Pro  Gly Val Pro Gly Ala  Lys Gly Glu Arg Gly  Glu Arg Gly 
    1595                 1600                 1605             


Asp Leu  Gln Ser Gln Ala Met  Val Arg Ser Val Ala  Arg Gln Val 
    1610                 1615                 1620             


Cys Glu  Gln Leu Ile Gln Ser  His Met Ala Arg Tyr  Thr Ala Ile 
    1625                 1630                 1635             


Leu Asn  Gln Ile Pro Ser His  Ser Ser Ser Ile Arg  Thr Val Gln 
    1640                 1645                 1650             


Gly Pro  Pro Gly Glu Pro Gly  Arg Pro Gly Ser Pro  Gly Ala Pro 
    1655                 1660                 1665             


Gly Glu  Gln Gly Pro Pro Gly  Thr Pro Gly Phe Pro  Gly Asn Ala 
    1670                 1675                 1680             


Gly Val  Pro Gly Thr Pro Gly  Glu Arg Gly Leu Thr  Gly Ile Lys 
    1685                 1690                 1695             


Gly Glu  Lys Gly Asn Pro Gly  Val Gly Thr Gln Gly  Pro Arg Gly 
    1700                 1705                 1710             


Pro Pro  Gly Pro Ala Gly Pro  Ser Gly Glu Ser Arg  Pro Gly Ser 
    1715                 1720                 1725             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Arg Gly Pro  Pro Gly His 
    1730                 1735                 1740             


Leu Gly  Val Pro Gly Pro Gln  Gly Pro Ser Gly Gln  Pro Gly Tyr 
    1745                 1750                 1755             


Cys Asp  Pro Ser Ser Cys Ser  Ala Tyr Gly Val Arg  Ala Pro His 
    1760                 1765                 1770             


Pro Asp  Gln Pro Glu Phe Thr  Pro Val Gln Asp Glu  Leu Glu Ala 
    1775                 1780                 1785             


Met Glu  Leu Trp Gly Pro Gly  Val 
    1790                 1795     


<210>  1657
<211>  1113
<212>  DNA
<213>  Homosapiens

<400>  1657
gacgcatttc cggttccctt cgtttaggtc ggctggaaat tatgtcctcc gtcggttttc     60

cgcagttttt ccaccaagcg agatattttt gggagttatt ccctaaataa ctgcattata    120

tgctcctttc atgacgaaat tgctgccgtg gagaagactg gaggaaactc gaggaagagg    180

gagaagccga caagtgctcg acgggctagg aactgtcctg cttgggtgtt agcgtttccc    240

gccgggccag taaggctgag tgacccggcg tggctactag gagaaggacg tacggtcctg    300

ctagtagagg aatatgtcga gtttctctag ggcgccccag caatgggcca cttttgctag    360

aatatggtat ctcttagatg ggaaaatgca gccacctggc aaacttgctg ctatggcatc    420

tataagactt cagggattac ataaacctgt gtaccatgca ctgagtgact gtggggatca    480

tgttgttata atgaacacaa gacacattgc attttctgga aacaaatggg aacaaaaagt    540

atactcttcg catactggct acccaggtgg atttagacaa gtaacagctg ctcagcttca    600

cctgagggat ccagtggcaa ttgtaaaact agctatttat ggcatgctgc caaaaaacct    660

tcacagaaga acaatgatgg aaaggttgca tctttttcca gatgagtata ttccagaaga    720

tattcttaag aatttagtag aggagcttcc tcaaccacga aaaataccta aacgtctaga    780

tgagtacaca caagaagaaa tagacgcctt cccaagattg tggactccac ctgaagatta    840

tcggctataa gagaataaga attgcagaaa ataacagtga agtgattgaa actttcttct    900

gatgagtttc tctaacctac aggatggagt aaaacaactg ctacagttca gcacctgttt    960

tatgtgccga atcactgtgg ggaaaggtca ggaaggtata gtccttcaat aggaaattgt   1020

aattaaaata taattttata gaaccatttt tatgtaatct gatttgaatg ttatagttga   1080

taataataaa atcacttact tggttgacta aaa                                1113


<210>  1658
<211>  178
<212>  PRT
<213>  Homosapiens

<400>  1658

Met Ser Ser Phe Ser Arg Ala Pro Gln Gln Trp Ala Thr Phe Ala Arg 
1               5                   10                  15      


Ile Trp Tyr Leu Leu Asp Gly Lys Met Gln Pro Pro Gly Lys Leu Ala 
            20                  25                  30          


Ala Met Ala Ser Ile Arg Leu Gln Gly Leu His Lys Pro Val Tyr His 
        35                  40                  45              


Ala Leu Ser Asp Cys Gly Asp His Val Val Ile Met Asn Thr Arg His 
    50                  55                  60                  


Ile Ala Phe Ser Gly Asn Lys Trp Glu Gln Lys Val Tyr Ser Ser His 
65                  70                  75                  80  


Thr Gly Tyr Pro Gly Gly Phe Arg Gln Val Thr Ala Ala Gln Leu His 
                85                  90                  95      


Leu Arg Asp Pro Val Ala Ile Val Lys Leu Ala Ile Tyr Gly Met Leu 
            100                 105                 110         


Pro Lys Asn Leu His Arg Arg Thr Met Met Glu Arg Leu His Leu Phe 
        115                 120                 125             


Pro Asp Glu Tyr Ile Pro Glu Asp Ile Leu Lys Asn Leu Val Glu Glu 
    130                 135                 140                 


Leu Pro Gln Pro Arg Lys Ile Pro Lys Arg Leu Asp Glu Tyr Thr Gln 
145                 150                 155                 160 


Glu Glu Ile Asp Ala Phe Pro Arg Leu Trp Thr Pro Pro Glu Asp Tyr 
                165                 170                 175     


Arg Leu 
        


<210>  1659
<211>  3081
<212>  DNA
<213>  Homosapiens

<400>  1659
gatgtggaag ccgagaccta aagttggggg gtgatctctg aggagatgga tcggtacctg     60

ctgctggtga tctgggggga aggaaaattc ccgtcggcgg ccagtaggga ggcagaacat    120

gggccagagg tgtcgtcggg tgagggtact gagaatcagc cggacttcac agcagcaaat    180

gtttatcacc tcttgaaaag aagcattagt gcttcaatta atccagaaga tagtactttc    240

cctgcctgtt cagtgggagg tatacctggt tccaagaagt ggttctttgc agtgcaggca    300

atatatggat tttatcagtt ttgtagttct gattggcaag agatacattt tgatacagaa    360

aaagataaaa ttgaagatgt tcttcaaacg aatatcgaag aatgtttggg tgctgttgag    420

tgttttgaag aagaagacag taatagcagg gaatcattat ccttggctga tctctatgaa    480

gaagctgcag aaaatttgca tcagctgtca gacaagcttc ctgctcctgg tagagcaatg    540

gtagatataa tactgttgct ttctgacaaa gatcctccta aattgaaaga ctatttacct    600

actgtaggag cattaaaaca tttgagagaa tggtattcag caaagatcac tatagcagga    660

aatcattgtg aaataaactg tcagaaaatt gcagaatacc tttctgctaa tgttgtatct    720

ttagaagatc tcagaaatgt tattgactca aaggaattat ggagggggaa aatacagata    780

tgggaaagaa agtttggatt tgaaattagt tttcctgaat tttgtttaaa gggagtcaca    840

cttaagaatt ttagtacttc taatttaaat actgacttcc ttgccaaaaa gatcatacca    900

tcaaaggata agaatatttt gccaaaggtt ttccattatt atggccctgc tttagaattt    960

gtgcagatga taaaattatc agatctaccc tcctgctata tgtcggatat tgaatttgag   1020

ttaggattga caaacagtac caaacagaat tctgtgttgc tgttggagca gatttcttct   1080

ctgtgtagca aggttggtgc tctttttgta ttgccatgta ccattagtaa catactgatt   1140

ccacctccca accaactcag ttcaagaaaa tggaaggaat atatagctaa aaagcctaaa   1200

acaatcagtg ttccagatgt tgaagtgaaa ggagagtgtt ctagctatta tctcttgtta   1260

caaggtaatg gcaatagaag atgtaaagcc acattgattc actcagccaa ccagatcaat   1320

ggctcatttg cactcaattt aattcatgga aagatgaaaa caaagacaga agaagccaaa   1380

ttgagttttc cttttgactt attatcactt ccacattttt ctggggagca gattgtacag   1440

agagagaaac agttagctaa tgttcaagtt ttagctttgg aagaatgcct aaaaagacga   1500

aagttggcaa agcagcctga aacagtttct gttgctgaac tcaaaagtct gttagtactc   1560

acaaggaaac actttttaga ttattttgat gctgtgattc ctaaaatgat tctaagaaag   1620

atggacaaaa ttaaaacctt caatatatta aatgatttta gtccagtgga acctaattcc   1680

tcaagtctaa tggaaaccaa tcctctggaa tggccagaaa ggcatgttct tcaaaatttg   1740

gaaacttttg aaaaaactaa acaaaaaatg agaactggtt cattacctca ttcatctgaa   1800

cagttgctgg gccacaaaga gggtcctcgg gactcaatca cattgttgga tgctaaagaa   1860

ttgctgaagt actttacctc agatggatta cccattggag atcttcaacc tttaccgatt   1920

caaaaggggg aaaagacttt tgttttgaca ccagaactta gtcctgggaa acttcaggtc   1980

ttaccttttg agaaagcctc agtatgtcat tatcatggaa ttgaatattg cttggatgac   2040

cgaaaagctt tggaaagaga tggaggattt tctgaacttc agtctcgtct tattcgttat   2100

gaaactcaaa ctacctgcac cagagaaagt tttccagtac ctactgtgtt gagccctctt   2160

ccatctcctg tagtttcgtc agatcctgga agtgtccctg acggagaagt tttacaaaat   2220

gaacttcgaa ctgaagtatc ccgattgaaa cggagatcta aagatctgaa ttgcctttat   2280

cccagaaaaa gacttgtgaa atctgaaagt tcagagtctc ttctttctca gacaactggt   2340

aatagtaatc actatcatca tcatgtgaca tccagaaagc cacaaacaga acggtcctta   2400

ccagtgactt gtccattggt tccaattcct agctgtgaaa ctccaaaact tgctacaaag   2460

accagttcag gtcaaaaaag tatgcatgaa tcaaaaacat caaggcaaat taaggaatca   2520

agatcacaga aacacacacg gatactgaaa gaagtagtta ctgaaaccct gaagaaacac   2580

agtattaccg agactcatga atgtttcact gcatgcagcc agcgtctctt tgaaatctct   2640

aagttctatc taaaggatct taaaacttca aggggtctat ttgaagaaat gaagaaaaca   2700

gcaaacaaca atgctgtaca ggtgattgac tgggtattag aaaagacaag caagaaatga   2760

tacataatca ttctctttaa gacaattata aattggatgg agctattatt cactacttct   2820

tttcttagtt tgaaaattat aaacaaattt taagctttat tcaaagaata gatgttatat   2880

ttctaaagaa tttcatgaat atatattcta tatttgtata gtttgaggga tgctatgtta   2940

atgtattttt aattagatac atattttgta aagtgttact atattttaaa gttattttta   3000

tatgttttaa aatgtttact cttatttaat tattacaata aacagaattt tttttttttt   3060

aaaaaaaaaa aaaaaaaaaa a                                             3081


<210>  1660
<211>  904
<212>  PRT
<213>  Homosapiens

<400>  1660

Met Asp Arg Tyr Leu Leu Leu Val Ile Trp Gly Glu Gly Lys Phe Pro 
1               5                   10                  15      


Ser Ala Ala Ser Arg Glu Ala Glu His Gly Pro Glu Val Ser Ser Gly 
            20                  25                  30          


Glu Gly Thr Glu Asn Gln Pro Asp Phe Thr Ala Ala Asn Val Tyr His 
        35                  40                  45              


Leu Leu Lys Arg Ser Ile Ser Ala Ser Ile Asn Pro Glu Asp Ser Thr 
    50                  55                  60                  


Phe Pro Ala Cys Ser Val Gly Gly Ile Pro Gly Ser Lys Lys Trp Phe 
65                  70                  75                  80  


Phe Ala Val Gln Ala Ile Tyr Gly Phe Tyr Gln Phe Cys Ser Ser Asp 
                85                  90                  95      


Trp Gln Glu Ile His Phe Asp Thr Glu Lys Asp Lys Ile Glu Asp Val 
            100                 105                 110         


Leu Gln Thr Asn Ile Glu Glu Cys Leu Gly Ala Val Glu Cys Phe Glu 
        115                 120                 125             


Glu Glu Asp Ser Asn Ser Arg Glu Ser Leu Ser Leu Ala Asp Leu Tyr 
    130                 135                 140                 


Glu Glu Ala Ala Glu Asn Leu His Gln Leu Ser Asp Lys Leu Pro Ala 
145                 150                 155                 160 


Pro Gly Arg Ala Met Val Asp Ile Ile Leu Leu Leu Ser Asp Lys Asp 
                165                 170                 175     


Pro Pro Lys Leu Lys Asp Tyr Leu Pro Thr Val Gly Ala Leu Lys His 
            180                 185                 190         


Leu Arg Glu Trp Tyr Ser Ala Lys Ile Thr Ile Ala Gly Asn His Cys 
        195                 200                 205             


Glu Ile Asn Cys Gln Lys Ile Ala Glu Tyr Leu Ser Ala Asn Val Val 
    210                 215                 220                 


Ser Leu Glu Asp Leu Arg Asn Val Ile Asp Ser Lys Glu Leu Trp Arg 
225                 230                 235                 240 


Gly Lys Ile Gln Ile Trp Glu Arg Lys Phe Gly Phe Glu Ile Ser Phe 
                245                 250                 255     


Pro Glu Phe Cys Leu Lys Gly Val Thr Leu Lys Asn Phe Ser Thr Ser 
            260                 265                 270         


Asn Leu Asn Thr Asp Phe Leu Ala Lys Lys Ile Ile Pro Ser Lys Asp 
        275                 280                 285             


Lys Asn Ile Leu Pro Lys Val Phe His Tyr Tyr Gly Pro Ala Leu Glu 
    290                 295                 300                 


Phe Val Gln Met Ile Lys Leu Ser Asp Leu Pro Ser Cys Tyr Met Ser 
305                 310                 315                 320 


Asp Ile Glu Phe Glu Leu Gly Leu Thr Asn Ser Thr Lys Gln Asn Ser 
                325                 330                 335     


Val Leu Leu Leu Glu Gln Ile Ser Ser Leu Cys Ser Lys Val Gly Ala 
            340                 345                 350         


Leu Phe Val Leu Pro Cys Thr Ile Ser Asn Ile Leu Ile Pro Pro Pro 
        355                 360                 365             


Asn Gln Leu Ser Ser Arg Lys Trp Lys Glu Tyr Ile Ala Lys Lys Pro 
    370                 375                 380                 


Lys Thr Ile Ser Val Pro Asp Val Glu Val Lys Gly Glu Cys Ser Ser 
385                 390                 395                 400 


Tyr Tyr Leu Leu Leu Gln Gly Asn Gly Asn Arg Arg Cys Lys Ala Thr 
                405                 410                 415     


Leu Ile His Ser Ala Asn Gln Ile Asn Gly Ser Phe Ala Leu Asn Leu 
            420                 425                 430         


Ile His Gly Lys Met Lys Thr Lys Thr Glu Glu Ala Lys Leu Ser Phe 
        435                 440                 445             


Pro Phe Asp Leu Leu Ser Leu Pro His Phe Ser Gly Glu Gln Ile Val 
    450                 455                 460                 


Gln Arg Glu Lys Gln Leu Ala Asn Val Gln Val Leu Ala Leu Glu Glu 
465                 470                 475                 480 


Cys Leu Lys Arg Arg Lys Leu Ala Lys Gln Pro Glu Thr Val Ser Val 
                485                 490                 495     


Ala Glu Leu Lys Ser Leu Leu Val Leu Thr Arg Lys His Phe Leu Asp 
            500                 505                 510         


Tyr Phe Asp Ala Val Ile Pro Lys Met Ile Leu Arg Lys Met Asp Lys 
        515                 520                 525             


Ile Lys Thr Phe Asn Ile Leu Asn Asp Phe Ser Pro Val Glu Pro Asn 
    530                 535                 540                 


Ser Ser Ser Leu Met Glu Thr Asn Pro Leu Glu Trp Pro Glu Arg His 
545                 550                 555                 560 


Val Leu Gln Asn Leu Glu Thr Phe Glu Lys Thr Lys Gln Lys Met Arg 
                565                 570                 575     


Thr Gly Ser Leu Pro His Ser Ser Glu Gln Leu Leu Gly His Lys Glu 
            580                 585                 590         


Gly Pro Arg Asp Ser Ile Thr Leu Leu Asp Ala Lys Glu Leu Leu Lys 
        595                 600                 605             


Tyr Phe Thr Ser Asp Gly Leu Pro Ile Gly Asp Leu Gln Pro Leu Pro 
    610                 615                 620                 


Ile Gln Lys Gly Glu Lys Thr Phe Val Leu Thr Pro Glu Leu Ser Pro 
625                 630                 635                 640 


Gly Lys Leu Gln Val Leu Pro Phe Glu Lys Ala Ser Val Cys His Tyr 
                645                 650                 655     


His Gly Ile Glu Tyr Cys Leu Asp Asp Arg Lys Ala Leu Glu Arg Asp 
            660                 665                 670         


Gly Gly Phe Ser Glu Leu Gln Ser Arg Leu Ile Arg Tyr Glu Thr Gln 
        675                 680                 685             


Thr Thr Cys Thr Arg Glu Ser Phe Pro Val Pro Thr Val Leu Ser Pro 
    690                 695                 700                 


Leu Pro Ser Pro Val Val Ser Ser Asp Pro Gly Ser Val Pro Asp Gly 
705                 710                 715                 720 


Glu Val Leu Gln Asn Glu Leu Arg Thr Glu Val Ser Arg Leu Lys Arg 
                725                 730                 735     


Arg Ser Lys Asp Leu Asn Cys Leu Tyr Pro Arg Lys Arg Leu Val Lys 
            740                 745                 750         


Ser Glu Ser Ser Glu Ser Leu Leu Ser Gln Thr Thr Gly Asn Ser Asn 
        755                 760                 765             


His Tyr His His His Val Thr Ser Arg Lys Pro Gln Thr Glu Arg Ser 
    770                 775                 780                 


Leu Pro Val Thr Cys Pro Leu Val Pro Ile Pro Ser Cys Glu Thr Pro 
785                 790                 795                 800 


Lys Leu Ala Thr Lys Thr Ser Ser Gly Gln Lys Ser Met His Glu Ser 
                805                 810                 815     


Lys Thr Ser Arg Gln Ile Lys Glu Ser Arg Ser Gln Lys His Thr Arg 
            820                 825                 830         


Ile Leu Lys Glu Val Val Thr Glu Thr Leu Lys Lys His Ser Ile Thr 
        835                 840                 845             


Glu Thr His Glu Cys Phe Thr Ala Cys Ser Gln Arg Leu Phe Glu Ile 
    850                 855                 860                 


Ser Lys Phe Tyr Leu Lys Asp Leu Lys Thr Ser Arg Gly Leu Phe Glu 
865                 870                 875                 880 


Glu Met Lys Lys Thr Ala Asn Asn Asn Ala Val Gln Val Ile Asp Trp 
                885                 890                 895     


Val Leu Glu Lys Thr Ser Lys Lys 
            900                 


<210>  1661
<211>  2978
<212>  DNA
<213>  Homosapiens

<400>  1661
aagggaagtc ggctcaggag gaccgagtga gggcaccgag gcgggacgca cgcacccggc     60

gaaggttgct ccaccccggt caggatcagg cgagggggaa ccagcctgag tgcagctgcc    120

aactcccgcc gagtgcgtct gcgaactccc ggagcggagt cccgcgtgcc gccacctccc    180

cgcggacgca ctctcctcgc tcccccgggc cccgcgtcct ccccccggcc acccttcccc    240

acttttcccc ccttttccaa tcacatggca ttttaagaat gccggaaaga tggcggtagc    300

ggcggcggcg gcggcggctg ggccggctgg cgcgggaggc ggccgggcgc agcggagcgg    360

gctgctggaa gttttggtgc gggatcgctg gcacaaagtt ctggtgaact tgagcgagga    420

cgccctggtt ctgagcagcg aggagggcgc tgcggcgtac aacggcatcg ggaccgccac    480

caatggctcg ttctgcaggg gcgccggggc tgggcacccg ggcgcgggcg gcgcgcagcc    540

cccggactcg cccgccgggg tccgcaccgc tttcaccgac ctgcccgagc aggtgcccga    600

gtccatctcg aaccagaagc gtggcgtgaa ggtgctgaag caggagctgg gcgggctggg    660

gatcagcatc aaggggggca aggagaacaa gatgcccatc ctcatcagca agatcttcaa    720

ggggctggcg gcggaccaga cccaagccct gtacgtgggc gacgccatcc tgtccgtgaa    780

cggagccgac ctgcgggacg ccacccacga cgaggcggtg caggcgttga agcgcgcggg    840

caaggaagtg ctgctggaag tgaagtacat gcgagaagcc acgccctatg tgaagaaagg    900

atccccagta tccgagattg ggtgggaaac acctccgcct gaatcccctc ggttaggggg    960

cagcacctca gaccccccgt catcgcagtc cttctccttc cacagagacc ggaaaagcat   1020

ccccctcaaa atgtgctacg tcactcggag tatggccttg gccgaccctg agaacaggca   1080

gcttgaaatc cactctccag atgctaagca cacggtgatc ctaaggagca aggactcagc   1140

cacggcccag gcatggttca gtgccatcca ttccaacgtt aatgacctgc tgacccgagt   1200

gattgctgag gtcagagagc agctggggaa aacaggcatt gctgggagcc gagagattag   1260

gcatcttggc tggcttgcag aaaaggtgcc aggggagagc aagaaacagt ggaaaccagc   1320

cctggttgtg ctgactgaga aagacctttt aatctatgac agcatgccac ggaggaagga   1380

agcctggttc agcccagttc acacataccc tcttcttgcc accaggctgg tccattcagg   1440

tccaggaaag ggatcacccc aggctggtgt ggatctgtcc tttgcaacgc gaactggtac   1500

caggcaaggg attgaaacac atctcttcag agcagagacc agcagggacc tctcccactg   1560

gacaaggagc atagtacagg gttgccacaa ttctgctgaa ctcattgctg aaatcagcac   1620

tgcttgcacc tacaaaaacc aggagtgccg tttgaccata cattatgaga atggattttc   1680

tattaccact gaaccacagg agggtgcctt tcccaagacc atcatacagt ctccttatga   1740

aaagctcaaa atgtcttcag atgatggaat caggatgctg tatttagatt ttggaggcaa   1800

agatggagag attcaactgg accttcattc ctgccccaag ccaattgttt tcatcattca   1860

ttccttcctg tcagctaaga ttacaagact gggcttggtg gcctgaagac aggggtgact   1920

tgcctttgag aaaagaaggg ctgcaatgcc accagagaac gtgatgtcag acaccatctg   1980

tagtgagcag cgcaccagat gtagcgtgct acagtcagct ttagctctca agagtcgtat   2040

gtaactgtcc cagactcctc tgtcagtttc agcaactaca agggataccc tgcgaaagta   2100

ccatgagaaa tatcagagta aaactttcta gaacagtaca aggttaaaga ggtgaggtga   2160

cgggaaatac acagcatagc tttgaaataa tgacaaccaa ggacatgacc attagaacag   2220

catgtgcaga tcttaatcat cccagttcct aggcaacttg ttcaccaggt acgcaagggc   2280

cgaatagttg agaaatggac atttttacct actcctccta gccccctatc cccagtaaca   2340

gtgatccctt ttcttattgt gatttatttc ctaattcttg ctgagttgac tttcccttgt   2400

aggaaaagaa aaatatttca aatagaaacc caccttttat ttaagtatga agcagctgtt   2460

actttttaaa aaatgaatta tctttcaatg gtgtagaatg attccaaagt gtctccatta   2520

gcatatactg agcaggaatt aaataaagca tcagatactg atctgagctg taagctggta   2580

gaatctgagc caaagtagac tgcttaaatt gataagcttt gctaaagagt tgtatgcaca   2640

aaggatgatt aattctggga ctatactcac accaaggtct gctgtcttat agccaagaat   2700

tacagcttta tttatagaga gtgaattatg ggtatttttt cagaaaatat tgtcatctga   2760

tatacacata aaacaactca cattgttgga gttaactaat tatccccatt tcatggtttt   2820

cagtggcaac ttactgaccc ttgtttttgc ctgtgcttgt atgcatgcat tttcaagcaa   2880

gtaataaagc agcctcattt aattctggat aatgctgggt tttacatata gactgaatgc   2940

tataatcaaa tctattgaca gtatctgcag ttctttca                           2978


<210>  1662
<211>  538
<212>  PRT
<213>  Homosapiens

<400>  1662

Met Ala Val Ala Ala Ala Ala Ala Ala Ala Gly Pro Ala Gly Ala Gly 
1               5                   10                  15      


Gly Gly Arg Ala Gln Arg Ser Gly Leu Leu Glu Val Leu Val Arg Asp 
            20                  25                  30          


Arg Trp His Lys Val Leu Val Asn Leu Ser Glu Asp Ala Leu Val Leu 
        35                  40                  45              


Ser Ser Glu Glu Gly Ala Ala Ala Tyr Asn Gly Ile Gly Thr Ala Thr 
    50                  55                  60                  


Asn Gly Ser Phe Cys Arg Gly Ala Gly Ala Gly His Pro Gly Ala Gly 
65                  70                  75                  80  


Gly Ala Gln Pro Pro Asp Ser Pro Ala Gly Val Arg Thr Ala Phe Thr 
                85                  90                  95      


Asp Leu Pro Glu Gln Val Pro Glu Ser Ile Ser Asn Gln Lys Arg Gly 
            100                 105                 110         


Val Lys Val Leu Lys Gln Glu Leu Gly Gly Leu Gly Ile Ser Ile Lys 
        115                 120                 125             


Gly Gly Lys Glu Asn Lys Met Pro Ile Leu Ile Ser Lys Ile Phe Lys 
    130                 135                 140                 


Gly Leu Ala Ala Asp Gln Thr Gln Ala Leu Tyr Val Gly Asp Ala Ile 
145                 150                 155                 160 


Leu Ser Val Asn Gly Ala Asp Leu Arg Asp Ala Thr His Asp Glu Ala 
                165                 170                 175     


Val Gln Ala Leu Lys Arg Ala Gly Lys Glu Val Leu Leu Glu Val Lys 
            180                 185                 190         


Tyr Met Arg Glu Ala Thr Pro Tyr Val Lys Lys Gly Ser Pro Val Ser 
        195                 200                 205             


Glu Ile Gly Trp Glu Thr Pro Pro Pro Glu Ser Pro Arg Leu Gly Gly 
    210                 215                 220                 


Ser Thr Ser Asp Pro Pro Ser Ser Gln Ser Phe Ser Phe His Arg Asp 
225                 230                 235                 240 


Arg Lys Ser Ile Pro Leu Lys Met Cys Tyr Val Thr Arg Ser Met Ala 
                245                 250                 255     


Leu Ala Asp Pro Glu Asn Arg Gln Leu Glu Ile His Ser Pro Asp Ala 
            260                 265                 270         


Lys His Thr Val Ile Leu Arg Ser Lys Asp Ser Ala Thr Ala Gln Ala 
        275                 280                 285             


Trp Phe Ser Ala Ile His Ser Asn Val Asn Asp Leu Leu Thr Arg Val 
    290                 295                 300                 


Ile Ala Glu Val Arg Glu Gln Leu Gly Lys Thr Gly Ile Ala Gly Ser 
305                 310                 315                 320 


Arg Glu Ile Arg His Leu Gly Trp Leu Ala Glu Lys Val Pro Gly Glu 
                325                 330                 335     


Ser Lys Lys Gln Trp Lys Pro Ala Leu Val Val Leu Thr Glu Lys Asp 
            340                 345                 350         


Leu Leu Ile Tyr Asp Ser Met Pro Arg Arg Lys Glu Ala Trp Phe Ser 
        355                 360                 365             


Pro Val His Thr Tyr Pro Leu Leu Ala Thr Arg Leu Val His Ser Gly 
    370                 375                 380                 


Pro Gly Lys Gly Ser Pro Gln Ala Gly Val Asp Leu Ser Phe Ala Thr 
385                 390                 395                 400 


Arg Thr Gly Thr Arg Gln Gly Ile Glu Thr His Leu Phe Arg Ala Glu 
                405                 410                 415     


Thr Ser Arg Asp Leu Ser His Trp Thr Arg Ser Ile Val Gln Gly Cys 
            420                 425                 430         


His Asn Ser Ala Glu Leu Ile Ala Glu Ile Ser Thr Ala Cys Thr Tyr 
        435                 440                 445             


Lys Asn Gln Glu Cys Arg Leu Thr Ile His Tyr Glu Asn Gly Phe Ser 
    450                 455                 460                 


Ile Thr Thr Glu Pro Gln Glu Gly Ala Phe Pro Lys Thr Ile Ile Gln 
465                 470                 475                 480 


Ser Pro Tyr Glu Lys Leu Lys Met Ser Ser Asp Asp Gly Ile Arg Met 
                485                 490                 495     


Leu Tyr Leu Asp Phe Gly Gly Lys Asp Gly Glu Ile Gln Leu Asp Leu 
            500                 505                 510         


His Ser Cys Pro Lys Pro Ile Val Phe Ile Ile His Ser Phe Leu Ser 
        515                 520                 525             


Ala Lys Ile Thr Arg Leu Gly Leu Val Ala 
    530                 535             


<210>  1663
<211>  2400
<212>  DNA
<213>  Homosapiens

<400>  1663
gtgcttttgc tgtgagcagc cccaagcagc tgggcgctcc atcagaggca actatgactt     60

ttgcaaagca aacgtgcaac cccaagcagc ggtctcccgg gccggggctg cgcggccgcc    120

gctgtgctgg cttttaacgg tgggagggca ccatcctctt gctctgctct cgttctccag    180

aaggctgtcc cggggccccc actctccgtc ccgctccggg gacagtggct cgcctgctat    240

gcgcggcagc ccgcgccggg gccggcacca gcagcgcccg ggcggatgca gcgagcccac    300

ggaggggcat gcttccacgc accaagtata accgcttcag gaatgactcg gtgacatcgg    360

tcgatgacct tctccacagc ctgtcggtga gcggcggcgg aggcaaggtt tcggcggcgc    420

gcgcgacccc ggcggcggct ccctacttgg tgtccggcga ggcgctgcgc aaggcgcccg    480

tcgatgggcc cggcagcctg ggccacctgc tccacaaggt gtcccacctg aaactctcca    540

gctcgggcct ccgcggcctg tcgtcggccg cccgggagcg ggcgggcgcg cggctctcgg    600

gcagctgcag cgcgcccagc ctggccgccc cggacggcag tgcgccctcg gcgccccgcg    660

ccccggccat gagcgccgcc aggaagggcc ggcccggcga cgagccgctg cccaggcccc    720

ctcggggggc gccgcacgcc agcgaccagg tgctggggcc cggagtcacc tacgtggtca    780

agtacttggg gtgcattgaa gttctgcgct caatgaggtc tcttgacttc agtacaagaa    840

cacaaattac cagggaagcc atcagccgcg tctgtgaagc tgtgcctggt gcgaagggag    900

ccttcaagaa gagaaagcct ccaagcaaaa tgctgtccag catcttggga aagagcaacc    960

tccagtttgc gggaatgagc atctctctga ccatctccac ggccagtctg aacctgcgaa   1020

ctccggactc caaacagatc atagcgaatc accacatgcg gtccatctcc ttcgcctctg   1080

ggggagaccc ggacacgact gactatgttg catatgtgac taaggaccct gttaatcgca   1140

gagcttgtca cattttggaa tgctgtgatg ggctggccca ggatgtcatc ggctccatcg   1200

gacaagcctt tgagctccgg tttaagcaat atttacagtg tcctaccaag attcccgctc   1260

tccatgatcg aatgcagagt ctggatgagc catggacgga agaggaggga gatggctcag   1320

accacccata ctacaacagc atcccaagca agatgcctcc tccagggggc tttcttgata   1380

ctagactgaa acccagaccc catgctcctg acacagccca gtttgcagga aaagagcaga   1440

cttattacca gggaagacac ttaggagaca cttttggcga agactggcag caaacacctt   1500

taaggcaagg gtcctcggac atctacagca cgccagaagg gaaactgcac gtggccccca   1560

cgggagaagc acccacctac gtcaacactc agcagatccc accacaggcc tggccggctg   1620

cggtcagcag tgctgagagc agcccaagga aagacctctt tgacatgaaa ccttttgaag   1680

atgctctcaa gaaccagccc ttggggcccg tgttaagcaa ggcagcctcc gtggagtgca   1740

tcagccctgt gtcacctaga gccccagatg ccaagatgct ggaggaactg caagccgaga   1800

cttggtacca aggagagatg agcaggaagg aggcagaggg gctgctggag aaagacggag   1860

acttcctggt caggaagagc accaccaacc cgggctcctt tgtcctcacg ggcatgcaca   1920

atggccaggc caagcacctg ctgctcgtgg acccagaagg cacgatccag acaaaggaca   1980

gagtctttga cagtatcagc cacctcatca accaccacct agaaagcagc ctgcccattg   2040

tctctgcagg gagtgagctg tgtctccagc agccagtgga gaggaagcag tgacatggcc   2100

agcactgctc ccggcactgc gcaccaggtc aggaggacct ggagtggact agaatcgggg   2160

ctgctggaac tgggacagct gcctgtggct cagagccttc ttcaaaagct tcaaaaggaa   2220

ggcttccttt aaggtcaagt ttcataaact tggttctgaa tttctcatat gcatattaaa   2280

ggtgtacata cctatacatc ctgtacaaat tatccctcta tatttatatt ttttaagact   2340

aagaaagacg taagactaat gttctgtgct gtatgttttt aatgaaaaaa aaaaaaaaaa   2400


<210>  1664
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  1664

Met Leu Pro Arg Thr Lys Tyr Asn Arg Phe Arg Asn Asp Ser Val Thr 
1               5                   10                  15      


Ser Val Asp Asp Leu Leu His Ser Leu Ser Val Ser Gly Gly Gly Gly 
            20                  25                  30          


Lys Val Ser Ala Ala Arg Ala Thr Pro Ala Ala Ala Pro Tyr Leu Val 
        35                  40                  45              


Ser Gly Glu Ala Leu Arg Lys Ala Pro Val Asp Gly Pro Gly Ser Leu 
    50                  55                  60                  


Gly His Leu Leu His Lys Val Ser His Leu Lys Leu Ser Ser Ser Gly 
65                  70                  75                  80  


Leu Arg Gly Leu Ser Ser Ala Ala Arg Glu Arg Ala Gly Ala Arg Leu 
                85                  90                  95      


Ser Gly Ser Cys Ser Ala Pro Ser Leu Ala Ala Pro Asp Gly Ser Ala 
            100                 105                 110         


Pro Ser Ala Pro Arg Ala Pro Ala Met Ser Ala Ala Arg Lys Gly Arg 
        115                 120                 125             


Pro Gly Asp Glu Pro Leu Pro Arg Pro Pro Arg Gly Ala Pro His Ala 
    130                 135                 140                 


Ser Asp Gln Val Leu Gly Pro Gly Val Thr Tyr Val Val Lys Tyr Leu 
145                 150                 155                 160 


Gly Cys Ile Glu Val Leu Arg Ser Met Arg Ser Leu Asp Phe Ser Thr 
                165                 170                 175     


Arg Thr Gln Ile Thr Arg Glu Ala Ile Ser Arg Val Cys Glu Ala Val 
            180                 185                 190         


Pro Gly Ala Lys Gly Ala Phe Lys Lys Arg Lys Pro Pro Ser Lys Met 
        195                 200                 205             


Leu Ser Ser Ile Leu Gly Lys Ser Asn Leu Gln Phe Ala Gly Met Ser 
    210                 215                 220                 


Ile Ser Leu Thr Ile Ser Thr Ala Ser Leu Asn Leu Arg Thr Pro Asp 
225                 230                 235                 240 


Ser Lys Gln Ile Ile Ala Asn His His Met Arg Ser Ile Ser Phe Ala 
                245                 250                 255     


Ser Gly Gly Asp Pro Asp Thr Thr Asp Tyr Val Ala Tyr Val Thr Lys 
            260                 265                 270         


Asp Pro Val Asn Arg Arg Ala Cys His Ile Leu Glu Cys Cys Asp Gly 
        275                 280                 285             


Leu Ala Gln Asp Val Ile Gly Ser Ile Gly Gln Ala Phe Glu Leu Arg 
    290                 295                 300                 


Phe Lys Gln Tyr Leu Gln Cys Pro Thr Lys Ile Pro Ala Leu His Asp 
305                 310                 315                 320 


Arg Met Gln Ser Leu Asp Glu Pro Trp Thr Glu Glu Glu Gly Asp Gly 
                325                 330                 335     


Ser Asp His Pro Tyr Tyr Asn Ser Ile Pro Ser Lys Met Pro Pro Pro 
            340                 345                 350         


Gly Gly Phe Leu Asp Thr Arg Leu Lys Pro Arg Pro His Ala Pro Asp 
        355                 360                 365             


Thr Ala Gln Phe Ala Gly Lys Glu Gln Thr Tyr Tyr Gln Gly Arg His 
    370                 375                 380                 


Leu Gly Asp Thr Phe Gly Glu Asp Trp Gln Gln Thr Pro Leu Arg Gln 
385                 390                 395                 400 


Gly Ser Ser Asp Ile Tyr Ser Thr Pro Glu Gly Lys Leu His Val Ala 
                405                 410                 415     


Pro Thr Gly Glu Ala Pro Thr Tyr Val Asn Thr Gln Gln Ile Pro Pro 
            420                 425                 430         


Gln Ala Trp Pro Ala Ala Val Ser Ser Ala Glu Ser Ser Pro Arg Lys 
        435                 440                 445             


Asp Leu Phe Asp Met Lys Pro Phe Glu Asp Ala Leu Lys Asn Gln Pro 
    450                 455                 460                 


Leu Gly Pro Val Leu Ser Lys Ala Ala Ser Val Glu Cys Ile Ser Pro 
465                 470                 475                 480 


Val Ser Pro Arg Ala Pro Asp Ala Lys Met Leu Glu Glu Leu Gln Ala 
                485                 490                 495     


Glu Thr Trp Tyr Gln Gly Glu Met Ser Arg Lys Glu Ala Glu Gly Leu 
            500                 505                 510         


Leu Glu Lys Asp Gly Asp Phe Leu Val Arg Lys Ser Thr Thr Asn Pro 
        515                 520                 525             


Gly Ser Phe Val Leu Thr Gly Met His Asn Gly Gln Ala Lys His Leu 
    530                 535                 540                 


Leu Leu Val Asp Pro Glu Gly Thr Ile Gln Thr Lys Asp Arg Val Phe 
545                 550                 555                 560 


Asp Ser Ile Ser His Leu Ile Asn His His Leu Glu Ser Ser Leu Pro 
                565                 570                 575     


Ile Val Ser Ala Gly Ser Glu Leu Cys Leu Gln Gln Pro Val Glu Arg 
            580                 585                 590         


Lys Gln 
        


<210>  1665
<211>  627
<212>  DNA
<213>  Homosapiens

<400>  1665
agtctccggc gagttgttgc ctgggctgga cgtggttttg tctgctgcgc ccgctcttcg     60

cgctctcgtt tcattttctg cagcgcgcca cgaggatggc ccacaagcag atctactact    120

cggacaagta cttcgacgaa cactacgagt accggcatgt tatgttaccc agagaacttt    180

ccaaacaagt acctaaaact catctgatgt ctgaagagga gtggaggaga cttggtgtcc    240

aacagagtct aggctgggtt cattacatga ttcatgagcc agaaccacat attcttctct    300

ttagacgacc tcttccaaaa gatcaacaaa aatgaagttt atctggggat cgtcaaatct    360

ttttcaaatt taatgtatat gtgtatataa ggtagtattc agtgaatact tgagaaatgt    420

acaaatcttt catccatacc tgtgcatgag ctgtattctt cacagcaaca gagctcagtt    480

aaatgcaact gcaagtaggt tactgtaaga tgtttaagat aaaagttctt ccagtcagtt    540

tttctcttaa gtgcctgttt gagtttactg aaacagttta cttttgttca ataaagtttg    600

tatgttgcat ttaaaaaaaa aaaaaaa                                        627


<210>  1666
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  1666

Met Ala His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Phe Asp Glu His 
1               5                   10                  15      


Tyr Glu Tyr Arg His Val Met Leu Pro Arg Glu Leu Ser Lys Gln Val 
            20                  25                  30          


Pro Lys Thr His Leu Met Ser Glu Glu Glu Trp Arg Arg Leu Gly Val 
        35                  40                  45              


Gln Gln Ser Leu Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro 
    50                  55                  60                  


His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Asp Gln Gln Lys 
65                  70                  75                  


<210>  1667
<211>  3457
<212>  DNA
<213>  Homosapiens

<400>  1667
ccaagccgac ggcccgctgc tggcctccgt gacgcggcct cctccgcgcc tcgcggcatg     60

gcgtcggagg ggccgcggga gcccgaaagc gagggcatca agttatcagc agatgtcaaa    120

ccatttgtcc ccagatttgc cgggctcaat gtggcatggt tagagtcctc agaagcatgt    180

gtcttcccca gctctgcagc cacatactat ccgtttgttc aggaaccacc agtgacagag    240

cagaaaatat atactgaaga catggccttt ggagcttcaa cttttccacc tcagtattta    300

tcttctgaga taactcttca tccatatgcc tattctcctt atacccttga ctccacacag    360

aatgtttact cagtgcctgg ctcccagtat ctttataacc aacccagttg ttaccgaggt    420

tttcaaacag tgaagcatcg aaatgagaac acatgccctc tcccacaaga aatgaaagct    480

ctgtttaaga agaaaaccta tgatgagaaa aaaacgtatg atcagcaaaa gtttgacagt    540

gaaagggctg atggaactat atcatctgag ataaaatcag ctagaggttc acatcatttg    600

tccatttacg ctgagaatag tttgaaatca gatggttacc ataagcgaac agacaggaaa    660

tccagaatca ttgcaaaaaa tgtatctacc tccaaacctg agtttgaatt taccacactg    720

gactttcctg aactgcaagg tgcagagaac aatatgtcag agatacagaa gcaacccaag    780

tggggacctg tccactctgt ctctaccgac atttctcttc taagagaagt agtaaaacca    840

gctgcagtgt tatcaaaggg tgaaatagtg gtgaaaaata acccaaatga atctgtaact    900

gctaatgccg ctaccaattc tccttcatgt acaagagagt tatcttggac accaatgggt    960

tatgttgttc gacagacatt atctacagaa ctgtcagcag cccctaaaaa tgttacttct   1020

atgataaact taaagaccat tgcttcatca gcagatccta aaaatgttag tataccatct   1080

tctgaagctt tatcttcgga tccttcctac aacaaagaaa aacacattat tcatcctacc   1140

caaaagtcta aagcatcaca aggtagtgac cttgaacaaa atgaagcctc aagaaagaat   1200

aagaaaaaga aagaaaaatc tacatcaaaa tatgaagtcc tgacagttca agagcctcca   1260

aggattgaag atgccgagga atttcccaac ctggcagttg catctgaaag aagagacaga   1320

atagagacac cgaaatttca atctaagcag cagccacagg ataattttaa aaataatgta   1380

aagaagagcc agcttccagt gcagttggac ttggggggca tgctgacagc cctggagaag   1440

aagcagcact ctcagcatgc aaagcagtcc tccaaaccag tggtagtctc agttggagca   1500

gtgccagtcc tttccaaaga atgtgcatca ggggagagag gccgccgcat gagtcaaatg   1560

aagaccccgc acaatccctt ggactccagc gccccactga tgaagaaagg gaagcagagg   1620

gagatcccca aggccaagaa gccaacctca ctgaagaaga ttattttgaa agaacggcaa   1680

gagagaaagc agcgtctcca agaaaatgct gtgagtccag cttttaccag tgatgacaca   1740

caagatggag agagtggtgg tgatgaccag tttcccgagc aggcagagct gtcagggcca   1800

gaggggatgg acgaactgat ctccactcct tcggttgagg acaagtctga agagccacca   1860

ggcacagagc tccagaggga cacagaggcc tcccaccttg ctcccaatca caccaccttc   1920

cctaagatcc acagccgcag attcagggat tactgcagcc agatgcttag taaagaagtg   1980

gatgcttgtg ttaccgacct actcaaagaa ctggtccgtt tccaagaccg tatgtaccag   2040

aaagatccag tcaaggccaa gactaaacgt cgacttgtgt tggggttgag ggaggttctc   2100

aaacacctga agctcaaaaa actgaaatgt gtcattattt ctcccaactg tgagaagata   2160

cagtcaaaag gtgggctgga tgacactttg cacacaatta ttgattatgc ctgtgagcag   2220

aacattccct ttgtgtttgc tctcaaccgc aaagctctgg ggcgcagttt gaataaggca   2280

gttcctgtca gtgtggtggg gatcttcagc tatgatgggg cccaggatca gttccacaag   2340

atggttgagc tgacagtggc ggcccgacag gcgtacaaga ccatgctgga gaatgtgcag   2400

caggagctgg tgggagagcc caggcctcag gcacctccca gcctactcac acagggcccc   2460

agctgccctg cagaagatgg ccccccagcc ctgaaagaaa aagaagagcc acactacatt   2520

gaaatctgga aaaaacatct ggaagcatac agtggatgta ccctggagct agaagaatcc   2580

ttggaggctt caacctctca aatgatgaat ttgaatttat gagagttctt gcctgtgtgt   2640

ctgtattttg ggtaaggagg ggaggtctga aaaagacttt ggggcttttt cttctgtttt   2700

tcatgacaat gtaatttgtg taactgttga atctggaaat tgatcagcat taaagggcac   2760

atgaagcagt gtctgcaggc gttcagtgct gcggagcctg ttaaaggtca ctcagatgtg   2820

caggtgttaa tcttctctaa aagcctggtg atacagctct ggctttctga gcacactacg   2880

gatctggaaa atactggaaa atgtgatact tagaatactt tggctgctaa ggaaacttcc   2940

tctccattgc agaatagctg agccaagtga gtgagtttgc agaaagcagg tggtgagctc   3000

ctgcctgctg gaggttgcca tggagggcca ttcctgcccg gcaacagcac cgtcctgcag   3060

ggagccactt ggcagaaggg tgcagggctg ctggtgtcag agcaagaggg ctacagggaa   3120

agggcccttt ctcaggggat gtagcttttt taaaagattt gggaacactt ggaggatttg   3180

ctaaaatgag cctcagaagg aaaattggtt ttctaacctg tgactttttg aaatgaatta   3240

ttcctttcag tctttatttt tcaaagaaac aatgtgtatt gaagtaccta gatttgtttg   3300

ataatcaaca aatctttcct ttttcaatga acatattctg aatgtggttt ctgtcttaga   3360

ccaggaggac agagtttgct ttcatatttt ccctgtaagt aagagggctt atttatttta   3420

aataaagagt aattattaaa aaaaaaaaaa aaaaaaa                            3457


<210>  1668
<211>  854
<212>  PRT
<213>  Homosapiens

<400>  1668

Met Ala Ser Glu Gly Pro Arg Glu Pro Glu Ser Glu Gly Ile Lys Leu 
1               5                   10                  15      


Ser Ala Asp Val Lys Pro Phe Val Pro Arg Phe Ala Gly Leu Asn Val 
            20                  25                  30          


Ala Trp Leu Glu Ser Ser Glu Ala Cys Val Phe Pro Ser Ser Ala Ala 
        35                  40                  45              


Thr Tyr Tyr Pro Phe Val Gln Glu Pro Pro Val Thr Glu Gln Lys Ile 
    50                  55                  60                  


Tyr Thr Glu Asp Met Ala Phe Gly Ala Ser Thr Phe Pro Pro Gln Tyr 
65                  70                  75                  80  


Leu Ser Ser Glu Ile Thr Leu His Pro Tyr Ala Tyr Ser Pro Tyr Thr 
                85                  90                  95      


Leu Asp Ser Thr Gln Asn Val Tyr Ser Val Pro Gly Ser Gln Tyr Leu 
            100                 105                 110         


Tyr Asn Gln Pro Ser Cys Tyr Arg Gly Phe Gln Thr Val Lys His Arg 
        115                 120                 125             


Asn Glu Asn Thr Cys Pro Leu Pro Gln Glu Met Lys Ala Leu Phe Lys 
    130                 135                 140                 


Lys Lys Thr Tyr Asp Glu Lys Lys Thr Tyr Asp Gln Gln Lys Phe Asp 
145                 150                 155                 160 


Ser Glu Arg Ala Asp Gly Thr Ile Ser Ser Glu Ile Lys Ser Ala Arg 
                165                 170                 175     


Gly Ser His His Leu Ser Ile Tyr Ala Glu Asn Ser Leu Lys Ser Asp 
            180                 185                 190         


Gly Tyr His Lys Arg Thr Asp Arg Lys Ser Arg Ile Ile Ala Lys Asn 
        195                 200                 205             


Val Ser Thr Ser Lys Pro Glu Phe Glu Phe Thr Thr Leu Asp Phe Pro 
    210                 215                 220                 


Glu Leu Gln Gly Ala Glu Asn Asn Met Ser Glu Ile Gln Lys Gln Pro 
225                 230                 235                 240 


Lys Trp Gly Pro Val His Ser Val Ser Thr Asp Ile Ser Leu Leu Arg 
                245                 250                 255     


Glu Val Val Lys Pro Ala Ala Val Leu Ser Lys Gly Glu Ile Val Val 
            260                 265                 270         


Lys Asn Asn Pro Asn Glu Ser Val Thr Ala Asn Ala Ala Thr Asn Ser 
        275                 280                 285             


Pro Ser Cys Thr Arg Glu Leu Ser Trp Thr Pro Met Gly Tyr Val Val 
    290                 295                 300                 


Arg Gln Thr Leu Ser Thr Glu Leu Ser Ala Ala Pro Lys Asn Val Thr 
305                 310                 315                 320 


Ser Met Ile Asn Leu Lys Thr Ile Ala Ser Ser Ala Asp Pro Lys Asn 
                325                 330                 335     


Val Ser Ile Pro Ser Ser Glu Ala Leu Ser Ser Asp Pro Ser Tyr Asn 
            340                 345                 350         


Lys Glu Lys His Ile Ile His Pro Thr Gln Lys Ser Lys Ala Ser Gln 
        355                 360                 365             


Gly Ser Asp Leu Glu Gln Asn Glu Ala Ser Arg Lys Asn Lys Lys Lys 
    370                 375                 380                 


Lys Glu Lys Ser Thr Ser Lys Tyr Glu Val Leu Thr Val Gln Glu Pro 
385                 390                 395                 400 


Pro Arg Ile Glu Asp Ala Glu Glu Phe Pro Asn Leu Ala Val Ala Ser 
                405                 410                 415     


Glu Arg Arg Asp Arg Ile Glu Thr Pro Lys Phe Gln Ser Lys Gln Gln 
            420                 425                 430         


Pro Gln Asp Asn Phe Lys Asn Asn Val Lys Lys Ser Gln Leu Pro Val 
        435                 440                 445             


Gln Leu Asp Leu Gly Gly Met Leu Thr Ala Leu Glu Lys Lys Gln His 
    450                 455                 460                 


Ser Gln His Ala Lys Gln Ser Ser Lys Pro Val Val Val Ser Val Gly 
465                 470                 475                 480 


Ala Val Pro Val Leu Ser Lys Glu Cys Ala Ser Gly Glu Arg Gly Arg 
                485                 490                 495     


Arg Met Ser Gln Met Lys Thr Pro His Asn Pro Leu Asp Ser Ser Ala 
            500                 505                 510         


Pro Leu Met Lys Lys Gly Lys Gln Arg Glu Ile Pro Lys Ala Lys Lys 
        515                 520                 525             


Pro Thr Ser Leu Lys Lys Ile Ile Leu Lys Glu Arg Gln Glu Arg Lys 
    530                 535                 540                 


Gln Arg Leu Gln Glu Asn Ala Val Ser Pro Ala Phe Thr Ser Asp Asp 
545                 550                 555                 560 


Thr Gln Asp Gly Glu Ser Gly Gly Asp Asp Gln Phe Pro Glu Gln Ala 
                565                 570                 575     


Glu Leu Ser Gly Pro Glu Gly Met Asp Glu Leu Ile Ser Thr Pro Ser 
            580                 585                 590         


Val Glu Asp Lys Ser Glu Glu Pro Pro Gly Thr Glu Leu Gln Arg Asp 
        595                 600                 605             


Thr Glu Ala Ser His Leu Ala Pro Asn His Thr Thr Phe Pro Lys Ile 
    610                 615                 620                 


His Ser Arg Arg Phe Arg Asp Tyr Cys Ser Gln Met Leu Ser Lys Glu 
625                 630                 635                 640 


Val Asp Ala Cys Val Thr Asp Leu Leu Lys Glu Leu Val Arg Phe Gln 
                645                 650                 655     


Asp Arg Met Tyr Gln Lys Asp Pro Val Lys Ala Lys Thr Lys Arg Arg 
            660                 665                 670         


Leu Val Leu Gly Leu Arg Glu Val Leu Lys His Leu Lys Leu Lys Lys 
        675                 680                 685             


Leu Lys Cys Val Ile Ile Ser Pro Asn Cys Glu Lys Ile Gln Ser Lys 
    690                 695                 700                 


Gly Gly Leu Asp Asp Thr Leu His Thr Ile Ile Asp Tyr Ala Cys Glu 
705                 710                 715                 720 


Gln Asn Ile Pro Phe Val Phe Ala Leu Asn Arg Lys Ala Leu Gly Arg 
                725                 730                 735     


Ser Leu Asn Lys Ala Val Pro Val Ser Val Val Gly Ile Phe Ser Tyr 
            740                 745                 750         


Asp Gly Ala Gln Asp Gln Phe His Lys Met Val Glu Leu Thr Val Ala 
        755                 760                 765             


Ala Arg Gln Ala Tyr Lys Thr Met Leu Glu Asn Val Gln Gln Glu Leu 
    770                 775                 780                 


Val Gly Glu Pro Arg Pro Gln Ala Pro Pro Ser Leu Leu Thr Gln Gly 
785                 790                 795                 800 


Pro Ser Cys Pro Ala Glu Asp Gly Pro Pro Ala Leu Lys Glu Lys Glu 
                805                 810                 815     


Glu Pro His Tyr Ile Glu Ile Trp Lys Lys His Leu Glu Ala Tyr Ser 
            820                 825                 830         


Gly Cys Thr Leu Glu Leu Glu Glu Ser Leu Glu Ala Ser Thr Ser Gln 
        835                 840                 845             


Met Met Asn Leu Asn Leu 
    850                 


<210>  1669
<211>  1837
<212>  DNA
<213>  Homosapiens

<400>  1669
agcccagaga aaaacaacag aggtttgcgg cagaagtggc caatgtcggg cccagagtcc     60

atgctcaagg ctggaagccc atcctggatg tgctgcactc ggcagtccta gtgtaattct    120

gcagggcccg gcccctgcca gggtctgagc tctccagcct gtggcatcta ctcccctcca    180

agcccacccc agtgtctcaa ttggagagac aggccctcat ggtccccact ctggcccagc    240

cccctctgca cacagctggc cgagctctgg gcctctccat gctgtggccc tggtgatggc    300

agagccttgg gatgtctctg tccatgtggt cacaggacat gtgtgtggca gcagggccat    360

ggtggggtgg gatgctgttc caaggcccag aaccattctg taagaaacca gcacagcgct    420

gcaagaaagg gggtcctagg ggacacaggc cacacaggtg tgctttgaaa aatggcaatt    480

aaggtcaaag agcaggaagt ccacaggacg ggccaaggcc aaggctcccg ctggccatgg    540

ggaagccacc tccagggcag tcccagggac tgaattggaa gttgtcccaa gtcacttcag    600

gtccaactgg gacagcagag gtaacccccc tgcaccctca tggggcagct tctttgggtc    660

ctaaatgtgg actcagaggt ggaaacggtc tgtgtcccca ggtcctgcag acattcgctt    720

tgtctgggag aagaatgggc gagctctgga gacctgtgtc cctgtgcaga cccatgcact    780

gcccgatggc agggcccatg cactcagctg gctgcaggac gccatcaggg aaagcgctga    840

gtatcgctgc tctgtcctct cctcagcagg gaacaagact tcgaaggtgc aggttgctgt    900

gatgagacct gaagtgaccc accaggagag gtggaccaga gagctctctg cctggagggc    960

tgtggctggg gagcacgacc ggatgatgca gagctggagg aaggcgtggg aaagctgtag   1020

caaggacacc ctgtagccac caggaaggag tccctgacac cgacctcaac cccaacaaga   1080

ccctgctgcc actgaccaca gccacccccg gagaaggcct ggtcccccac aactgtgaac   1140

tgtcttgccc aagcctgctc tgaacacagc cattgggcca ccacctgatg ggcagaggcg   1200

ggacagtgga gaagcctgga acccaagtgg gcctgtgaca ggaactaaga cttaaaaaat   1260

taggtgctta cctgggacag taagttctgt ctggcacaag caggtaacca ggatggctaa   1320

caggctttga tagctgctcg tgaactaaaa cagcagggtg tgtgcaggtt cctcctctac   1380

ggtcaggcag caggctctga aggctgatcc tacaccgtcc cagtgactcc ccttgacaga   1440

gtgcccccac cccctaatag ccaacagggt tagcatggcc agcacagatc gctgctttta   1500

ttgatgcaaa tcaagcctgc tgcttctcct ccctgcagac ttagccaagg aactccaaga   1560

tgcatgactg ggacaagaaa aggtgagact ccacatggaa atgccttgcc ctaaaccttg   1620

aatgactgtg agatgcgatc tgggagtgca tctgtcaagt ctttgtgttt tcttcactaa   1680

cctcagaata ctgggctcta ttttatcaag cgctgcagtt tatgcctctg tcccgtcaat   1740

gctcagcttc tgcaacagga caccaaactt gatgcagaaa gccaaatagg tcaattatgc   1800

aaatctcctg gtgccatatt aaatttcttg acaatgg                            1837


<210>  1670
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  1670

Met Trp Thr Gln Arg Trp Lys Arg Ser Val Ser Pro Gly Pro Ala Asp 
1               5                   10                  15      


Ile Arg Phe Val Trp Glu Lys Asn Gly Arg Ala Leu Glu Thr Cys Val 
            20                  25                  30          


Pro Val Gln Thr His Ala Leu Pro Asp Gly Arg Ala His Ala Leu Ser 
        35                  40                  45              


Trp Leu Gln Asp Ala Ile Arg Glu Ser Ala Glu Tyr Arg Cys Ser Val 
    50                  55                  60                  


Leu Ser Ser Ala Gly Asn Lys Thr Ser Lys Val Gln Val Ala Val Met 
65                  70                  75                  80  


Arg Pro Glu Val Thr His Gln Glu Arg Trp Thr Arg Glu Leu Ser Ala 
                85                  90                  95      


Trp Arg Ala Val Ala Gly Glu His Asp Arg Met Met Gln Ser Trp Arg 
            100                 105                 110         


Lys Ala Trp Glu Ser Cys Ser Lys Asp Thr Leu 
        115                 120             


<210>  1671
<211>  4675
<212>  DNA
<213>  Homosapiens

<400>  1671
gctgtaacac tcaccgtgaa ggtctgcagc ttcactcccg agccagcgag accacgaacc     60

caccagaagg aagaaactct gaacacatct gaacatcaga agggacagac tccagacgcg    120

ccaccactct gctaacacca gatagtggaa agaaaccatg tgctgaaatg tttgacgaca    180

ctgatggttt gactctgcta actggaatgg cttattgtgc aagaaagtac acctggtcgg    240

gtcctggggc tcatctctag caccagcaaa gatttctgaa gacgtctttc tagaaatgac    300

tggaaagttt caagaggcat aagatacagc atttcttctg aggccctgaa gaagtatcaa    360

gtgggctttg acattgcggt ggtgagagcg acccctcctc acctggagaa ctgggaaatg    420

tggattctca gggaccgcgc tgttcacgag ctccaggctg tgctgctggc cctggtcctg    480

gggcgctgag ccgcatctgc aatagcacac ttgcccggcc acctgctgcc gtgagccttt    540

gctgctgaag cccctggggt cgcctctacc tgatgaggat gtgcaccccc attagggggc    600

tgctcatggc ccttgcagtg atgtttggga cagcgatggc atttgcaccc ataccccgga    660

tcacctggga gcacagagag gtgcacctgg tgcagtttca tgagccagac atctacaact    720

actcagcctt gctgctgagc gaggacaagg acaccttgta cataggtgcc cgggaggcgg    780

tcttcgctgt gaacgcactc aacatctccg agaagcagca tgaggtgtat tggaaggtct    840

cagaagacaa aaaagcaaaa tgtgcagaaa aggggaaatc aaaacagaca gagtgcctca    900

actacatccg ggtgctgcag ccactcagcg ccacttccct ttacgtgtgt gggaccaacg    960

cattccagcc ggcctgtgac cacctgaact taacatcctt taagtttctg gggaaaaatg   1020

aagatggcaa aggaagatgt ccctttgacc cagcacacag ctacacatcc gtcatggttg   1080

atggagaact ttattcgggg acgtcgtata attttttggg aagtgaaccc atcatctccc   1140

gaaattcttc ccacagtcct ctgaggacag aatatgcaat cccttggctg aacgagccta   1200

gtttcgtgtt tgctgacgtg atccgaaaaa gcccagacag ccccgacggc gaggatgaca   1260

gggtctactt cttcttcacg gaggtgtctg tggagtatga gtttgtgttc agggtgctga   1320

tcccacggat agcaagagtg tgcaaggggg accagggcgg cctgaggacc ttgcagaaga   1380

aatggacctc cttcctgaaa gcccgactca tctgctcccg gccagacagc ggcttggtct   1440

tcaatgtgct gcgggatgtc ttcgtgctca ggtccccggg cctgaaggtg cctgtgttct   1500

atgcactctt caccccacag ctgaacaacg tggggctgtc ggcagtgtgc gcctacaacc   1560

tgtccacagc cgaggaggtc ttctcccacg ggaagtacat gcagagcacc acagtggagc   1620

agtcccacac caagtgggtg cgctataatg gcccggtacc caagccgcgg cctggagcgt   1680

gcatcgacag cgaggcacgg gccgccaact acaccagctc cttgaatttg ccagacaaga   1740

cgctgcagtt cgttaaagac caccctttga tggatgactc ggtaacccca atagacaaca   1800

ggcccaggtt aatcaagaaa gatgtgaact acacccagat cgtggtggac cggacccagg   1860

ccctggatgg gactgtctat gatgtcatgt ttgtcagcac agaccgggga gctctgcaca   1920

aagccatcag cctcgagcac gctgttcaca tcatcgagga gacccagctc ttccaggact   1980

ttgagccagt ccagaccctg ctgctgtctt caaagaaggg caacaggttt gtctatgctg   2040

gctctaactc gggcgtggtc caggccccgc tggccttctg tgggaagcac ggcacctgcg   2100

aggactgtgt gctggcgcgg gacccctact gcgcctggag cccgcccaca gcgacctgcg   2160

tggctctgca ccagaccgag agccccagca ggggtttgat tcaggagatg agcggcgatg   2220

cttctgtgtg cccggataaa agtaaaggaa gttaccggca gcattttttc aagcacggtg   2280

gcacagcgga actgaaatgc tcccaaaaat ccaacctggc ccgggtcttt tggaagttcc   2340

agaatgacgt gttgaaggcc gagagcccca agtacggtct tatgggcaga aaaaacttgc   2400

tcatcttcaa cttgtcagaa ggagacagtg gggtgtacca gtgcctgtca gaggagaggg   2460

ttaagaacaa aacggtcttc caagtggtcg ccaagcacgt cctggaagtg aaggtggttc   2520

caaagcccgt agtggccccc accttgtcag ttgttcagac agaaggtagt aggattgcca   2580

ccaaagtgtt ggtggcatcc acccaagggt cttctccccc aaccccagcc gtgcaggcca   2640

cctcctccgg ggccatcacc cttcctccca agcctgcgcc caccggcaca tcctgcgaac   2700

caaagatcgt catcaacacg gtcccccagc tccactcgga gaaaaccatg tatcttaagt   2760

ccagcgacaa ccgcctcctc atgtccctct tcctcttctt ctttgttctc ttcctctgcc   2820

tctttttcta caactgctat aagggatacc tgcccagaca gtgcttgaaa ttccgctcgg   2880

ccctactaat tgggaagaag aagcccaagt cagatttctg tgaccgtgag cagagcctga   2940

aggagacgtt agtagagcca gggagcttct cccagcagaa tggggagcac cccaagccag   3000

ccctggacac cggctatgag accgagcaag acaccatcac cagcaaagtc cccacggata   3060

gggaggactc acagaggatc gacgaccttt ctgccaggga caagcccttt gacgtcaagt   3120

gtgagctgaa gttcgctgac tcagacgcag atggagactg aggccggctg tgcatccccg   3180

ctggtgcctc ggctgcgacg tgtccaggcg tggagagttt tgtgtttctc ctgttcagta   3240

tccgagtctc gtgcagtgct gcgtaggtta gcccgcatcg tgcagacaac ctcagtcctc   3300

ttgtctattt tctcttgggt tgagcctgtg acttggtttc tctttgtcct tttggaaaaa   3360

tgacaatcct tgcatcccag tcttgtgttc cgaagtcagt cggagtactt gaagaaggcc   3420

cacgggcggc acggagttcc tgagcccttt ctgtagtggg ggaaaggtgg ctggacctct   3480

gttggctgag aagagcatcc cttcagcttc ccctccccgt agcagccact aaaagattat   3540

ttaattccag attggaaatg acattttagt ttatcagatt ggtaacttat cgcctgttgt   3600

ccagattggc acgaaccttt tcttccactt aattattttt ttaggatttt gctttgattg   3660

tgtttatgtc atgggtcatt tttttttagt tacagaagca gatgtgttaa tatttagaag   3720

aagatgtata tcttccagat tttgttatat atttggcata aaatacggct tacgttgctt   3780

aagattctca gggataaact tccttttgct aaatgcattc tttctgcttt tagaaatgta   3840

gacataaaca ctccccggag cccactcacc ttttttcttt ttcttttttt ttttttaact   3900

ttattccttg agggaagcat tgtttttgga gagattttct ttctgtactt cgttttactt   3960

ttcttttttt ttaactttta ctctctcgaa gaagaggacc ttcccacatc cacgaggtgg   4020

gttttgagca agggaaggta gcctggatga gctgagtgga gccaggctgg cccagagctg   4080

agatgggagt gcggtacaat ctggagccca cagctgtcgg tcagaacctc ctgtgagaca   4140

gatggaacct tcacaagggc gcctttggtt ctctgaacat ctcctttctc ttcttgcttc   4200

aattgcatac ccactgcctg cccagacttt ctatccagcc tcactgagct gcccactact   4260

ggaagggaac tgggcctcgg tggccggggc cgcgagctgt gaccacagca ccctcaagca   4320

tacggcgctg ttcctgccac tgtcctgaag atgtgaatgg gtggtacgat ttcaacactg   4380

gttaatttca cactccatct ccccgctttg taaataccca tcgggaagag actttttttc   4440

catggtgaag agcaataaac tctggatgtt tgtgcgcgtg tgtggacagt cttatcttcc   4500

agcatgatag gatttgacca ttttggtgta aacatttgtg ttttataaga tttaccttgt   4560

ttttattttt ctactttgaa ttgtatacat ttggaaagta cccaaataaa tgagaagctt   4620

ctatccttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        4675


<210>  1672
<211>  862
<212>  PRT
<213>  Homosapiens

<400>  1672

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Asp 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  1673
<211>  3935
<212>  DNA
<213>  Homosapiens

<400>  1673
cccacgcgtc cgggctaggg cgccggagcc gcacgcagcc gcggggctcc gagaggcgcg     60

cactggggct gggactgcgc ggcgccgccg ctgcgagcgc cactgagcgg tcgcgcaact    120

tcggaggcac agcgccggag ccaggcgagc gctcagagac ccggagccag aggggcgcgc    180

cggagcctcg ttcgagagcc ggcgccaggc acccaccgcg ctccgagtgc caggcggccc    240

tccgcgcagc gtggcttccg ctgcccccac ggaaggcacg ggctggcgct gccgggcgcc    300

ggggaggacg gcgaggagga ggcggcggcg gcggagacgg cggcggcgag actggggcca    360

gggagacagc cctgggggag aggcgcccga accaggccgc gggagcatgg gggcccggag    420

cggagctcgg ggcgcgctgc tgctggcact gctgctctgc tgggacccga ggctgagcca    480

agcaggcact gattctggca gcgaggtgct ccctgactcc ttcccgtcag cgccagcaga    540

gccgctgccc tacttcctgc aggagccaca ggacgcctac attgtgaaga acaagcctgt    600

ggagctccgc tgccgcgcct tccccgccac acagatctac ttcaagtgca acggcgagtg    660

ggtcagccag aacgaccacg tcacacagga aggcctggat gaggccaccg gcctgcgggt    720

gcgcgaggtg cagatcgagg tgtcgcggca gcaggtggag gagctctttg ggctggagga    780

ttactggtgc cagtgcgtgg cctggagctc cgcgggcacc accaagagtc gccgagccta    840

cgtccgcatc gcctacctgc gcaagaactt cgatcaggag cctctgggca aggaggtgcc    900

cctggaccat gaggttctcc tgcagtgccg cccgccggag ggggtgcctg tggccgaggt    960

ggaatggctc aagaatgagg atgtcatcga ccccacccag gacaccaact tcctgctcac   1020

catcgaccac aacctcatca tccgccaggc ccgcctgtcg gacactgcca actatacctg   1080

cgtggccaag aacatcgtgg ccaaacgccg gagcaccact gccaccgtca tcgtctacgt   1140

gaatggcggc tggtccagct gggcagagtg gtcaccctgc tccaaccgct gtggccgagg   1200

ctggcagaag cgcacccgga cctgcaccaa ccccgctcca ctcaacggag gggccttctg   1260

cgagggccag gcattccaga agaccgcctg caccaccatc tgcccagtcg atggggcgtg   1320

gacggagtgg agcaagtggt cagcctgcag cactgagtgt gcccactggc gtagccgcga   1380

gtgcatggcg cccccacccc agaacggagg ccgtgactgc agcgggacgc tgctcgactc   1440

taagaactgc acagatgggc tgtgcatgca aaataagaaa actctaagcg accccaacag   1500

ccacctgctg gaggcctcag gggatgcggc gctgtatgcg gggctcgtgg tggccatctt   1560

cgtggtcgtg gcaatcctca tggcggtggg ggtggtggtg taccgccgca actgccgtga   1620

cttcgacaca gacatcactg actcatctgc tgccctgact ggtggtttcc accccgtcaa   1680

ctttaagacg gcaaggccca gcaacccgca gctcctacac ccctctgtgc ctcctgacct   1740

gacagccagc gccggcatct accgcggacc cgtgtatgcc ctgcaggact ccaccgacaa   1800

aatccccatg accaactctc ctctgctgga ccccttaccc agccttaagg tcaaggtcta   1860

cagctccagc accacgggct ctgggccagg cctggcagac ggggctgacc tgctgggggt   1920

cttgccgcct ggcacatacc ctagcgattt cgcccgggac acccacttcc tgcacctgcg   1980

cagcgccagc ctcggttccc agcagctctt gggcctgccc cgagacccag ggagcagcgt   2040

cagcggcacc tttggctgcc tgggtgggag gctcagcatc cccggcacag gggtcagctt   2100

gctggtgccc aatggagcca ttccccaggg caagttctac gagatgtatc tactcatcaa   2160

caaggcagaa agtaccctcc cgctttcaga agggacccag acagtattga gcccctcggt   2220

gacctgtgga cccacaggcc tcctgctgtg ccgccccgtc atcctcacca tgccccactg   2280

tgccgaagtc agtgcccgtg actggatctt tcagctcaag acccaggccc accagggcca   2340

ctgggaggag gtggtgaccc tggatgagga gaccctgaac acaccctgct actgccagct   2400

ggagcccagg gcctgtcaca tcctgctgga ccagctgggc acctacgtgt tcacgggcga   2460

gtcctattcc cgctcagcag tcaagcggct ccagctggcc gtcttcgccc ccgccctctg   2520

cacctccctg gagtacagcc tccgggtcta ctgcctggag gacacgcctg tagcactgaa   2580

ggaggtgctg gagctggagc ggactctggg cggatacttg gtggaggagc cgaaaccgct   2640

aatgttcaag gacagttacc acaacctgcg cctctccctc catgacctcc cccatgccca   2700

ttggaggagc aagctgctgg ccaaatacca ggagatcccc ttctatcaca tttggagtgg   2760

cagccagaag gccctccact gcactttcac cctggagagg cacagcttgg cctccacaga   2820

gctcacctgc aagatctgcg tgcggcaagt ggaaggggag ggccagatat tccagctgca   2880

taccactctg gcagagacac ctgctggctc cctggacact ctctgctctg cccctggcag   2940

cactgtcacc acccagctgg gaccttatgc cttcaagatc ccactgtcca tccgccagaa   3000

gatatgcaac agcctagatg cccccaactc acggggcaat gactggcgga tgttagcaca   3060

gaagctctct atggaccggt acctgaatta ctttgccacc aaagcgagcc ccacgggtgt   3120

gatcctggac ctctgggaag ctctgcagca ggacgatggg gacctcaaca gcctggcgag   3180

tgccttggag gagatgggca agagtgagat gctggtggct gtggccaccg acggggactg   3240

ctgagcctcc tgggacagcg ggctggcagg gactggcagg aggcaggtgc agggaggcct   3300

ggggcagcct cctgatgggg atgtttggcc tctgcttcct cccagttcac agccagagtt   3360

gcctctcctc ctcctcttcc ccaaccccca gaccatgacc agccttagaa aatccatgta   3420

ctctgttgtt agagggccca gagttccttc tccacccccg ctctctctct cttggcctga   3480

gatctctgtg caggaaccaa gatggggctg aagcctctgg aggcagttgg ttgggggcgg   3540

gcaggcagga ggccctccct ccaccccccc accctcagcc cggcaacttc tgggttccat   3600

gggttttagt tccgttctcg ttttcttcct ccgttattga tttctccttt ctccctaagc   3660

ccccttctgc ttccacgccc ttttcctctt tgaagagtca agtacaattc agacaaactg   3720

ctttctcctg tccaaaagca aaaaggcaaa ggaaagaaag aaagcttcag accgctagta   3780

aggctcaaag aagaagaaaa acaccaaaac cacaagggaa aagaaaaacc cagtttctta   3840

ggaaacgcaa acgatttatt atccagatta tttggataag tcctttttaa gaaaaaaaaa   3900

agaaaatgaa aaacaacaca aaaaaaaaaa aaaaa                              3935


<210>  1674
<211>  945
<212>  PRT
<213>  Homosapiens

<400>  1674

Met Gly Ala Arg Ser Gly Ala Arg Gly Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Cys Trp Asp Pro Arg Leu Ser Gln Ala Gly Thr Asp Ser Gly Ser 
            20                  25                  30          


Glu Val Leu Pro Asp Ser Phe Pro Ser Ala Pro Ala Glu Pro Leu Pro 
        35                  40                  45              


Tyr Phe Leu Gln Glu Pro Gln Asp Ala Tyr Ile Val Lys Asn Lys Pro 
    50                  55                  60                  


Val Glu Leu Arg Cys Arg Ala Phe Pro Ala Thr Gln Ile Tyr Phe Lys 
65                  70                  75                  80  


Cys Asn Gly Glu Trp Val Ser Gln Asn Asp His Val Thr Gln Glu Gly 
                85                  90                  95      


Leu Asp Glu Ala Thr Gly Leu Arg Val Arg Glu Val Gln Ile Glu Val 
            100                 105                 110         


Ser Arg Gln Gln Val Glu Glu Leu Phe Gly Leu Glu Asp Tyr Trp Cys 
        115                 120                 125             


Gln Cys Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Arg Ala 
    130                 135                 140                 


Tyr Val Arg Ile Ala Tyr Leu Arg Lys Asn Phe Asp Gln Glu Pro Leu 
145                 150                 155                 160 


Gly Lys Glu Val Pro Leu Asp His Glu Val Leu Leu Gln Cys Arg Pro 
                165                 170                 175     


Pro Glu Gly Val Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp 
            180                 185                 190         


Val Ile Asp Pro Thr Gln Asp Thr Asn Phe Leu Leu Thr Ile Asp His 
        195                 200                 205             


Asn Leu Ile Ile Arg Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr 
    210                 215                 220                 


Cys Val Ala Lys Asn Ile Val Ala Lys Arg Arg Ser Thr Thr Ala Thr 
225                 230                 235                 240 


Val Ile Val Tyr Val Asn Gly Gly Trp Ser Ser Trp Ala Glu Trp Ser 
                245                 250                 255     


Pro Cys Ser Asn Arg Cys Gly Arg Gly Trp Gln Lys Arg Thr Arg Thr 
            260                 265                 270         


Cys Thr Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln 
        275                 280                 285             


Ala Phe Gln Lys Thr Ala Cys Thr Thr Ile Cys Pro Val Asp Gly Ala 
    290                 295                 300                 


Trp Thr Glu Trp Ser Lys Trp Ser Ala Cys Ser Thr Glu Cys Ala His 
305                 310                 315                 320 


Trp Arg Ser Arg Glu Cys Met Ala Pro Pro Pro Gln Asn Gly Gly Arg 
                325                 330                 335     


Asp Cys Ser Gly Thr Leu Leu Asp Ser Lys Asn Cys Thr Asp Gly Leu 
            340                 345                 350         


Cys Met Gln Asn Lys Lys Thr Leu Ser Asp Pro Asn Ser His Leu Leu 
        355                 360                 365             


Glu Ala Ser Gly Asp Ala Ala Leu Tyr Ala Gly Leu Val Val Ala Ile 
    370                 375                 380                 


Phe Val Val Val Ala Ile Leu Met Ala Val Gly Val Val Val Tyr Arg 
385                 390                 395                 400 


Arg Asn Cys Arg Asp Phe Asp Thr Asp Ile Thr Asp Ser Ser Ala Ala 
                405                 410                 415     


Leu Thr Gly Gly Phe His Pro Val Asn Phe Lys Thr Ala Arg Pro Ser 
            420                 425                 430         


Asn Pro Gln Leu Leu His Pro Ser Val Pro Pro Asp Leu Thr Ala Ser 
        435                 440                 445             


Ala Gly Ile Tyr Arg Gly Pro Val Tyr Ala Leu Gln Asp Ser Thr Asp 
    450                 455                 460                 


Lys Ile Pro Met Thr Asn Ser Pro Leu Leu Asp Pro Leu Pro Ser Leu 
465                 470                 475                 480 


Lys Val Lys Val Tyr Ser Ser Ser Thr Thr Gly Ser Gly Pro Gly Leu 
                485                 490                 495     


Ala Asp Gly Ala Asp Leu Leu Gly Val Leu Pro Pro Gly Thr Tyr Pro 
            500                 505                 510         


Ser Asp Phe Ala Arg Asp Thr His Phe Leu His Leu Arg Ser Ala Ser 
        515                 520                 525             


Leu Gly Ser Gln Gln Leu Leu Gly Leu Pro Arg Asp Pro Gly Ser Ser 
    530                 535                 540                 


Val Ser Gly Thr Phe Gly Cys Leu Gly Gly Arg Leu Ser Ile Pro Gly 
545                 550                 555                 560 


Thr Gly Val Ser Leu Leu Val Pro Asn Gly Ala Ile Pro Gln Gly Lys 
                565                 570                 575     


Phe Tyr Glu Met Tyr Leu Leu Ile Asn Lys Ala Glu Ser Thr Leu Pro 
            580                 585                 590         


Leu Ser Glu Gly Thr Gln Thr Val Leu Ser Pro Ser Val Thr Cys Gly 
        595                 600                 605             


Pro Thr Gly Leu Leu Leu Cys Arg Pro Val Ile Leu Thr Met Pro His 
    610                 615                 620                 


Cys Ala Glu Val Ser Ala Arg Asp Trp Ile Phe Gln Leu Lys Thr Gln 
625                 630                 635                 640 


Ala His Gln Gly His Trp Glu Glu Val Val Thr Leu Asp Glu Glu Thr 
                645                 650                 655     


Leu Asn Thr Pro Cys Tyr Cys Gln Leu Glu Pro Arg Ala Cys His Ile 
            660                 665                 670         


Leu Leu Asp Gln Leu Gly Thr Tyr Val Phe Thr Gly Glu Ser Tyr Ser 
        675                 680                 685             


Arg Ser Ala Val Lys Arg Leu Gln Leu Ala Val Phe Ala Pro Ala Leu 
    690                 695                 700                 


Cys Thr Ser Leu Glu Tyr Ser Leu Arg Val Tyr Cys Leu Glu Asp Thr 
705                 710                 715                 720 


Pro Val Ala Leu Lys Glu Val Leu Glu Leu Glu Arg Thr Leu Gly Gly 
                725                 730                 735     


Tyr Leu Val Glu Glu Pro Lys Pro Leu Met Phe Lys Asp Ser Tyr His 
            740                 745                 750         


Asn Leu Arg Leu Ser Leu His Asp Leu Pro His Ala His Trp Arg Ser 
        755                 760                 765             


Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His Ile Trp Ser 
    770                 775                 780                 


Gly Ser Gln Lys Ala Leu His Cys Thr Phe Thr Leu Glu Arg His Ser 
785                 790                 795                 800 


Leu Ala Ser Thr Glu Leu Thr Cys Lys Ile Cys Val Arg Gln Val Glu 
                805                 810                 815     


Gly Glu Gly Gln Ile Phe Gln Leu His Thr Thr Leu Ala Glu Thr Pro 
            820                 825                 830         


Ala Gly Ser Leu Asp Thr Leu Cys Ser Ala Pro Gly Ser Thr Val Thr 
        835                 840                 845             


Thr Gln Leu Gly Pro Tyr Ala Phe Lys Ile Pro Leu Ser Ile Arg Gln 
    850                 855                 860                 


Lys Ile Cys Asn Ser Leu Asp Ala Pro Asn Ser Arg Gly Asn Asp Trp 
865                 870                 875                 880 


Arg Met Leu Ala Gln Lys Leu Ser Met Asp Arg Tyr Leu Asn Tyr Phe 
                885                 890                 895     


Ala Thr Lys Ala Ser Pro Thr Gly Val Ile Leu Asp Leu Trp Glu Ala 
            900                 905                 910         


Leu Gln Gln Asp Asp Gly Asp Leu Asn Ser Leu Ala Ser Ala Leu Glu 
        915                 920                 925             


Glu Met Gly Lys Ser Glu Met Leu Val Ala Val Ala Thr Asp Gly Asp 
    930                 935                 940                 


Cys 
945 


<210>  1675
<211>  2243
<212>  DNA
<213>  Homosapiens

<400>  1675
cgccggaggc agcggcggcg tggcgcagcg gcgacatggc cgttgtctca gaggacgact     60

ttcagcacag ttcaaactcc acctacggaa ccacaagcag cagtctccga gctgaccagg    120

aggcactgct tgagaagctg ctggaccgcc cgccccctgg cctgcagagg cccgaggacc    180

gcttctgtgg cacatacatc atcttcttca gcctgggcat tggcagtcta ctgccatgga    240

acttctttat cactgccaag gagtactgga tgttcaaact ccgcaactcc tccagcccag    300

ccaccgggga ggaccctgag ggctcagaca tcctgaacta ctttgagagc taccttgccg    360

ttgcctccac cgtgccctcc atgctgtgcc tggtggccaa cttcctgctt gtcaacaggg    420

ttgcagtcca catccgtgtc ctggcctcac tgacggtcat cctggccatc ttcatggtga    480

taactgcact ggtgaaggtg gacacttcct cctggacccg tggttttttt gcggtcacca    540

ttgtctgcat ggtgatcctc agcggtgcct ccactgtctt cagcagcagc atctacggca    600

tgaccggctc ctttcctatg aggaactccc aagcactgat atcaggagga gccatgggcg    660

ggacggtcag cgccgtggcc tcattggtgg acttggctgc atccagtgat gtgaggaaca    720

gcgccctggc cttcttcctg acggccacca tcttcctcgt gctctgcatg ggactctacc    780

tgctgctgtc caggctggag tatgccaggt actacatgag gcctgttctt gcggcccatg    840

tgttttctgg tgaagaggag cttccccagg actccctcag tgccccttcg gtggcctcca    900

gattcattga ttcccacaca ccccctctcc gccccatcct gaagaagacg gccagcctgg    960

gcttctgtgt cacctacgtc ttcttcatca ccagcctcat ctaccccgcc gtctgcacca   1020

acatcgagtc cctcaacaag ggctcgggct cactgtggac caccaagttt ttcatccccc   1080

tcactacctt cctcctgtac aactttgctg acctatgtgg ccggcagctc accgcctgga   1140

tccaggtgcc agggcccaac agcaaggcgc tcccagggtt cgtgctcctc cggacctgcc   1200

tcatccccct cttcgtgctc tgtaactacc agccccgcgt ccacctgaag actgtggtct   1260

tccagtccga tgtgtacccc gcactcctca gctccctgct ggggctcagc aacggctacc   1320

tcagcaccct ggccctcctc tacgggccta agattgtgcc cagggagctg gctgaggcca   1380

cgggagtggt gatgtccttt tatgtgtgct tgggcttaac actgggctca gcctgctcta   1440

ccctcctggt gcacctcatc tagaagggag gacacaagga cattggtgct tcagagcctt   1500

tgaagatgag aagagagtgc aggagggctg ggggccatgg aggaaaggcc taaagtttca   1560

cttggggaca gagagcagag cacactcggg cctcatccct cccaagatgc cagtgagcca   1620

cgtccatgcc cattccgtgc aaggcagata ttccagtcat attaacagaa cactcctgag   1680

acagttgaag aagaaatagc acaaatcagg ggtactccct tcacagctga tggttaacat   1740

tccaccttct ttctagccct tcaaagatgc tgccagtgtt cgccctagag ttattacaaa   1800

gccagtgcca aaacccagcc atgggctctt tgcaacctcc cagctgcgct cattccagct   1860

gacagcgaga tgcaagcaaa tgctcagctc tccttaccct gaaggggtct ccctggaatg   1920

gaagtcccct ggcatggtca gtcctcaggc ccaagactca agtgtgcaca gacccctgtg   1980

ttctgcgggt gaacaactgc ccactaacca gactggaaaa cccagaaaga tgggccttcc   2040

atgaatgctt cattccagag ggaccagagg gcctccctgt gcaagggatc aagcatgtct   2100

ggcctgggtt ttcaaaaaaa gagggatcct catgacctgg tggtctatgg cctgggtcaa   2160

gatgagggtc tttcagtgtt cctgtttaca acatgtcaaa gccattggtt caagggcgta   2220

ataaatactt gcgtattcaa aaa                                           2243


<210>  1676
<211>  475
<212>  PRT
<213>  Homosapiens

<400>  1676

Met Ala Val Val Ser Glu Asp Asp Phe Gln His Ser Ser Asn Ser Thr 
1               5                   10                  15      


Tyr Gly Thr Thr Ser Ser Ser Leu Arg Ala Asp Gln Glu Ala Leu Leu 
            20                  25                  30          


Glu Lys Leu Leu Asp Arg Pro Pro Pro Gly Leu Gln Arg Pro Glu Asp 
        35                  40                  45              


Arg Phe Cys Gly Thr Tyr Ile Ile Phe Phe Ser Leu Gly Ile Gly Ser 
    50                  55                  60                  


Leu Leu Pro Trp Asn Phe Phe Ile Thr Ala Lys Glu Tyr Trp Met Phe 
65                  70                  75                  80  


Lys Leu Arg Asn Ser Ser Ser Pro Ala Thr Gly Glu Asp Pro Glu Gly 
                85                  90                  95      


Ser Asp Ile Leu Asn Tyr Phe Glu Ser Tyr Leu Ala Val Ala Ser Thr 
            100                 105                 110         


Val Pro Ser Met Leu Cys Leu Val Ala Asn Phe Leu Leu Val Asn Arg 
        115                 120                 125             


Val Ala Val His Ile Arg Val Leu Ala Ser Leu Thr Val Ile Leu Ala 
    130                 135                 140                 


Ile Phe Met Val Ile Thr Ala Leu Val Lys Val Asp Thr Ser Ser Trp 
145                 150                 155                 160 


Thr Arg Gly Phe Phe Ala Val Thr Ile Val Cys Met Val Ile Leu Ser 
                165                 170                 175     


Gly Ala Ser Thr Val Phe Ser Ser Ser Ile Tyr Gly Met Thr Gly Ser 
            180                 185                 190         


Phe Pro Met Arg Asn Ser Gln Ala Leu Ile Ser Gly Gly Ala Met Gly 
        195                 200                 205             


Gly Thr Val Ser Ala Val Ala Ser Leu Val Asp Leu Ala Ala Ser Ser 
    210                 215                 220                 


Asp Val Arg Asn Ser Ala Leu Ala Phe Phe Leu Thr Ala Thr Ile Phe 
225                 230                 235                 240 


Leu Val Leu Cys Met Gly Leu Tyr Leu Leu Leu Ser Arg Leu Glu Tyr 
                245                 250                 255     


Ala Arg Tyr Tyr Met Arg Pro Val Leu Ala Ala His Val Phe Ser Gly 
            260                 265                 270         


Glu Glu Glu Leu Pro Gln Asp Ser Leu Ser Ala Pro Ser Val Ala Ser 
        275                 280                 285             


Arg Phe Ile Asp Ser His Thr Pro Pro Leu Arg Pro Ile Leu Lys Lys 
    290                 295                 300                 


Thr Ala Ser Leu Gly Phe Cys Val Thr Tyr Val Phe Phe Ile Thr Ser 
305                 310                 315                 320 


Leu Ile Tyr Pro Ala Val Cys Thr Asn Ile Glu Ser Leu Asn Lys Gly 
                325                 330                 335     


Ser Gly Ser Leu Trp Thr Thr Lys Phe Phe Ile Pro Leu Thr Thr Phe 
            340                 345                 350         


Leu Leu Tyr Asn Phe Ala Asp Leu Cys Gly Arg Gln Leu Thr Ala Trp 
        355                 360                 365             


Ile Gln Val Pro Gly Pro Asn Ser Lys Ala Leu Pro Gly Phe Val Leu 
    370                 375                 380                 


Leu Arg Thr Cys Leu Ile Pro Leu Phe Val Leu Cys Asn Tyr Gln Pro 
385                 390                 395                 400 


Arg Val His Leu Lys Thr Val Val Phe Gln Ser Asp Val Tyr Pro Ala 
                405                 410                 415     


Leu Leu Ser Ser Leu Leu Gly Leu Ser Asn Gly Tyr Leu Ser Thr Leu 
            420                 425                 430         


Ala Leu Leu Tyr Gly Pro Lys Ile Val Pro Arg Glu Leu Ala Glu Ala 
        435                 440                 445             


Thr Gly Val Val Met Ser Phe Tyr Val Cys Leu Gly Leu Thr Leu Gly 
    450                 455                 460                 


Ser Ala Cys Ser Thr Leu Leu Val His Leu Ile 
465                 470                 475 


<210>  1677
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1677
gcggcggcgg cggctcggga gagagggacg cgggctgcag gcgcgatgct tggctagagg     60

acgcgtccga cggcggccgg acgctgaggt ggtcggggct agtcagcccg gcctgggcat    120

ggagcgcggg gtggcagagc ctctggacgt ttggggcgcg cccagtccga gcccccggcg    180

cgcctgaagt tgcgagcggc gagcggcgag cggcgagcgg cccgcggaga cccaggagct    240

gccggcacgc cgcggatgag ccttcgcgcc ggcgggaaga cgcggcggtg gccagggcca    300

gagcaggcgg cccgcggggg ccgatccggc ggagagcaga gcccgaggcg aggcgaggcg    360

cggcgccgct gcacacacgc acacggagcc atggggcgcc atgttgccac cagctgccac    420

gtggcctggc ttttggtgct gatctctgga tgctggggcc aggtgaaccg gctgcccttc    480

ttcaccaacc acttctttga tacatacctg ctgatcagcg aggacacgcc tgtgggttct    540

tctgtgaccc agttgctggc ccaagacatg gacaatgacc ccctggtgtt tggcgtgtct    600

ggggaggagg cctctcgctt ctttgcagtg gagcctgaca ctggcgtggt gtggctccgg    660

cagccactgg acagagagac caagtcagag ttcaccgtgg agttctctgt cagcgaccac    720

cagggggtga tcacacggaa ggtgaacatc caggttgggg atgtgaatga caacgcgccc    780

acatttcaca atcagcccta cagcgtccgc atccctgaga atacaccagt ggggacgccc    840

atcttcatcg tgaatgccac agaccccgac ttgggggcag ggggcagcgt cctctactcc    900

ttccagcccc cctcccaatt cttcgccatt gacagcgccc gcggtatcgt cacagtgatc    960

cgggagctgg actacgagac cacacaggcc taccagctca cggtcaacgc cacagatcaa   1020

gacaagacca ggcctctgtc caccctggcc aacttggcca tcatcatcac agatgtccag   1080

gacatggacc ccatcttcat caacctgcct tacagcacca acatctacga gcattctcct   1140

ccgggcacga cggtgcgcat catcaccgcc atagaccagg ataaaggacg tccccggggc   1200

attggctaca ccatcgtttc agggaatacc aacagcatct ttgccctgga ctacatcagc   1260

ggagtgctga ccttgaatgg cctgctggac cgggagaacc ccctgtacag ccatggcttc   1320

atcctgactg tgaagggcac ggagctgaac gatgaccgca ccccatctga cgctacagtc   1380

accacgacct tcaatatcct ggttattgac atcaatgaca atgccccgga gttcaacagc   1440

tccgagtaca gcgtggccat cactgagctg gcacaggtcg gctttgccct tccactcttc   1500

atccaggtgg tggacaagga tgagaatttg ggcctgaaca gcatgtttga ggtgtacttg   1560

gtggggaaca actcccacca cttcatcatc tccccgacct ccgtccaggg gaaggcggac   1620

attcgtattc gggtggccat cccactggac tacgagaccg tggaccgcta cgactttgat   1680

ctctttgcca atgagagtgt gcctgaccat gtgggctatg ccaaggtgaa gatcactctc   1740

atcaatgaaa atgacaaccg gcccatcttc agccagccac tgtacaacat cagcctgtac   1800

gagaacgtca ccgtggggac ctctgtgctg acagtcctgg caactgacaa tgatgcaggc   1860

acctttgggg aagtcagcta cttcttcagt gatgaccctg acaggttctc gctggacaag   1920

gacacgggac tcatcatgct gattgccagg ctggactatg agctcatcca gcgcttcacc   1980

ctgacgatca ttgcccggga cgggggcggc gaggagacca caggccgggt caggatcaat   2040

gtgttggatg tcaacgacaa cgtgcccacc ttccagaagg atgcctacgt gggtgctctg   2100

cgggagaacg agccttctgt cacacagctg gtgcggctcc gggcaacaga tgaagactcc   2160

cctcccaaca accagatcac ctacagcatt gtcagtgcat ctgcctttgg cagctacttc   2220

gacatcagcc tgtacgaggg ctatggagtg atcagcgtca gtcgccccct ggattatgaa   2280

cagatatcca atgggctgat ttatctgacg gtcatggcca tggatgctgg caacccccct   2340

ctcaacagca ccgtccctgt caccatcgag gtgtttgatg agaatgacaa ccctcccacc   2400

ttcagcaagc ccgcctactt cgtctccgtg gtggagaaca tcatggcagg agccacggtg   2460

ctgttcctga atgccacaga cctggaccgc tcccgggagt acggccagga gtccatcatc   2520

tactccttgg aaggctccac ccagtttcgg atcaatgccc gctcagggga aatcaccacc   2580

acgtctctgc ttgaccgaga gaccaagtct gaatacatcc tcatcgttcg cgcagtggac   2640

gggggtgtgg gccacaacca gaaaactggc atcgccaccg taaacatcac cctcctggac   2700

atcaatgaca accaccccac gtggaaggac gcaccctact acatcaacct ggtggagatg   2760

acccctccag actctgatgt gaccacggtg gtggctgttg acccagacct gggggagaat   2820

ggcaccctgg tgtacagcat ccagccaccc aacaagttct acagcctcaa cagcaccacg   2880

ggcaagatcc gcaccaccca cgccatgctg gaccgggaga accccgaccc ccatgaggcc   2940

gagctgatgc gcaaaatcgt cgtctctgtt actgactgtg gcaggccccc tctgaaagcc   3000

accagcagtg ccacagtgtt tgtgaacctc ttggatctca atgacaatga ccccaccttt   3060

cagaacctgc cttttgtggc cgaggtgctt gaaggcatcc cggcgggggt ctccatctac   3120

caagtggtgg ccatcgacct cgatgagggc ctgaacggcc tggtgtccta ccgcatgccg   3180

gtgggcatgc cccgcatgga cttcctcatc aacagcagca gcggcgtggt ggtcaccacc   3240

accgagctgg accgcgagcg catcgcggag taccagctgc gggtggtggc cagtgatgca   3300

ggcacgccca ccaagagctc caccagcacg ctcaccatcc atgtgctgga tgtgaacgac   3360

gagacgccca ccttcttccc ggccgtgtac aatgtgtctg tgtccgagga cgtgccacgc   3420

gagttccggg tggtctggct gaactgcacg gacaacgacg tgggcctcaa tgcagagctc   3480

agctacttca tcacaggtgg caacgtggat gggaagttca gcgtgggtta ccgcgatgcc   3540

gttgtgagaa ccgtggtggg cctggaccgg gagaccacag ccgcctacat gctcatcctg   3600

gaggccatcg acaacggccc tgtagggaag cgacacacgg gcacagccac cgtgttcgtc   3660

actgtcctgg atgtgaatga caaccggccc atctttctgc agagcagcta tgaggccagc   3720

gtccctgagg acatccctga aggccacagc atcttgcagc tgaaagccac ggacgcagat   3780

gagggcgagt ttgggcgtgt gtggtaccgc atcctccatg gtaaccatgg caacaacttc   3840

cggatccatg tcagcaatgg gctcctgatg cgagggcccc ggcccctgga ccgggagcgg   3900

aactcatccc acgtgctgat agtggaggcc tacaaccacg acctgggccc catgcggagc   3960

tccgtcaggg tgattgtgta cgtggaggac atcaacgatg aggcccccgt gttcacacag   4020

cagcagtaca gccgtctggg gcttcgagag accgcaggca ttggaacgtc agtcatcgtg   4080

gtccaagcca cagaccgaga ctctggggat ggtggcctgg tgaactaccg catcctgtcg   4140

ggcgcagagg ggaagtttga gattgacgag agcacagggc ttatcatcac cgtgaattac   4200

ctggactacg agaccaagac cagctacatg atgaatgtgt cggccactga ccaggccccg   4260

cccttcaacc agggcttctg cagcgtctac atcactctgc tcaacgagct ggacgaggcc   4320

gtgcagttct ccaatgcctc atacgaggct gccatcctgg agaatctggc actgggtact   4380

gagattgtgc gggtccaggc ctactccatc gacaacctca accaaatcac gtaccgcttc   4440

aacgcctaca ccagcaccca ggccaaagcc ctcttcaaga tagacgccat cacgggtgtg   4500

atcacagtcc agggcctggt ggaccgtgag aagggcgact tctatacctt gacagtggtg   4560

gcagatgacg gcggccccaa ggtggactcc accgtgaagg tctacatcac tgtgctggac   4620

gagaatgaca acagcccccg gtttgacttc acctccgact cggcggtcag catacccgag   4680

gactgccctg tgggccagcg agtggctact gtcaaggcct gggaccctga tgctggcagc   4740

aatgggcagg tggtcttctc cctggcctct ggcaacatcg cgggggcctt tgagatcgtc   4800

accaccaatg actccattgg cgaagtgttt gtggccaggc ccctggacag agaagagctg   4860

gatcactaca tcctccaggt tgtggcttct gaccgaggca cccctccacg gaagaaggac   4920

cacatcctgc aggtgaccat cctggacatc aatgacaacc ctccagtcat cgagagcccc   4980

tttggataca atgtcagtgt gaatgagaac gtgggtggag gtactgctgt ggtccaggtg   5040

agagccactg accgtgacat cgggatcaac agtgttctgt cctactacat caccgagggc   5100

aacaaggaca tggccttccg catggaccgc atcagcggtg agatcgccac acggcctgcc   5160

ccgcctgacc gcgagcgcca gagcttctac cacctggtgg ccactgtgga ggacgagggc   5220

accccaaccc tgtcggccac cacgcacgtg tacgtgacca ttgtggatga gaatgataac   5280

gcgcccatgt tccagcagcc ccactatgag gtgctgctgg atgagggccc agacacgctc   5340

aacaccagcc tcatcaccat ccaggcactg gacctggatg agggtcccaa cggcacagtc   5400

acctatgcca tcgtcgcagg caacatcgtc aacaccttcc gcatcgacag acacatgggt   5460

gtcatcactg ctgccaaaga gctggactac gagatcagcc acggccgcta caccctgatc   5520

gtcactgcca cagaccagtg ccccatctta tcccaccgcc tcacctctac caccacggtg   5580

cttgtgaatg tgaatgacat caacgacaat gtgcctacct tcccccggga ctatgaggga   5640

ccatttgaag tcactgaggg ccagccgggg cccagagtgt ggaccttcct ggcccatgac   5700

cgagactcag gacccaacgg gcaggtggag tacagcatca tggatggaga ccctctgggt   5760

gagtttgtga tctctcctgt ggagggggtg ctaagggtcc ggaaggacgt ggagctggac   5820

cgggagacca tcgccttcta caacctgacc atctgtgccc gtgaccgggg gatgccccca   5880

ctcagctcca caatgctggt ggggatccgg gtgctggaca tcaacgacaa cgaccctgtg   5940

ctgctgaacc tgcccatgaa catcaccatc agcgagaaca gccctgtctc cagctttgtc   6000

gcccatgtcc tggccagtga cgctgacagt ggctgcaatg cacgcctcac cttcaacatc   6060

actgcgggca accgcgagcg ggccttcttc atcaatgcca cgacagggat cgtcactgtg   6120

aaccggcccc tggaccgcga gcggatccca gagtacaagc tgaccatttc tgtgaaggac   6180

aacccggaga atccacgcat agccaggagg gattatgact tgcttctgat cttcctttct   6240

gatgagaatg acaaccaccc cctcttcact aaaagcacct accaggcaga ggtgatggaa   6300

aactctcccg ctggcacccc tctcacggtg ctcaatgggc ccatcctggc cctggatgca   6360

gaccaagaca tctacgccgt ggtgacctac cagctgctgg gtgcccagag tggcctcttt   6420

gacatcaaca gcagcaccgg tgtggtgacc gtgaggtcag gtgtcatcat tgaccgggag   6480

gcattctcgc cacccatcct ggagctgctg ctgctggctg aggacatcgg gctgctcaac   6540

agcacggccc acctgctcat caccatcctg gatgacaatg acaaccggcc cacctttagc   6600

cctgccaccc tcactgtcca tctgctagag aactgcccgc ctggattctc agtccttcaa   6660

gtcacagcca cagatgagga cagtggcctc aatggggagc tggtctaccg aatagaagct   6720

ggggctcagg accgcttcct cattcatctg gtcaccgggg tcatccgtgt tggtaatgcc   6780

accatcgaca gagaggagca ggagtcctac aggctaacgg tggtggccac cgaccggggc   6840

accgttcctc tctcgggcac agccattgtc accattctga tcgatgacat caatgactcc   6900

cgccccgagt tcctcaaccc catccagaca gtgagcgtgc tggagtcggc tgagccaggc   6960

actgtcattg ccaatatcac ggccattgac cacgacctca acccaaagct agagtaccac   7020

attgtcggca ttgtggccaa ggacgacact gatcgcctgg tgcccaacca ggaggacgcc   7080

tttgctgtga atatcaacac aggatctgta atggtgaagt cccccatgaa tcgggagctg   7140

gttgccacct atgaggtcac tctctcagtg attgacaatg ccagcgacct accagagcgc   7200

tctgtcagtg tgccaaatgc caagctgact gtcaacgtcc tggacgtcaa tgacaatacg   7260

ccccagttca agccctttgg gatcacctac tacatggagc ggatcctgga gggggccacc   7320

cctgggacca cactcattgc tgtggcagcc gtggaccctg acaagggcct taatgggctg   7380

gtcacctaca ccctgctgga cctggtgccc ccagggtatg tccagctgga ggactcctcg   7440

gcagggaagg tcattgccaa ccggacagtg gactacgagg aggtgcactg gctcaacttt   7500

accgtgaggg cctcagacaa cgggtccccg ccccgggcag ctgagatccc tgtctacctg   7560

gaaatcgtgg acatcaatga caacaacccc atctttgacc agccctccta ccaggaggct   7620

gtctttgagg atgtgcctgt gggcacaatc atcctgacag tcactgccac tgatgctgac   7680

tcaggcaact ttgcactcat tgagtacagc cttggagatg gagagagcaa gtttgccatc   7740

aaccccacca cgggtgacat ctatgtgctg tcttctctgg accgggagaa gaaggaccac   7800

tatatcctga ctgccttggc caaagacaac cctggggatg tagccagcaa ccgtcgcgaa   7860

aattcagtgc aggtggtgat ccaagtgctg gatgtcaatg actgccggcc acagttctcc   7920

aagccccagt tcagcacaag cgtgtatgag aatgagccgg cgggcacctc ggtcatcacc   7980

atgatggcca ctgaccagga tgaaggtccc aatggagagt tgacctactc acttgagggc   8040

cctggcgtgg aggccttcca tgtggacatg gactcgggct tggtgaccac acagcggcca   8100

ctgcagtcct acgagaagtt cagtctgacc gtggtggcca cagatggtgg agagccccca   8160

ctctggggca ccaccatgct cctggtggag gt                                 8192


<210>  1678
<211>  3354
<212>  PRT
<213>  Homosapiens

<400>  1678

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Lys Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Ala  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr Gln  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  1679
<211>  2022
<212>  DNA
<213>  Homosapiens

<400>  1679
gcggcggcgg cggctcggga gagagggacg cgggctgcag gcgcgatgct tggctagagg     60

acgcgtccga cggcggccgg acgctgaggt ggtcggggct agtcagcccg gcctgggcat    120

ggagcgcggg gtggcagagc ctctggacgt ttggggcgcg cccagtccga gcccccggcg    180

cgcctgaagt tgcgagcggc gagcggcgag cggcgagcgg cccgcggaga cccaggagct    240

gccggcacgc cgcggatgag ccttcgcgcc ggcgggaaga cgcggcggtg gccagggcca    300

gagcaggcgg cccgcggggg ccgatccggc ggagagcaga gcccgaggcg aggcgaggcg    360

cggcgccgct gcacacacgc acacggagcc atggggcgcc atgttgccac cagctgccac    420

gtggcctggc ttttggtgct gatctctgga tgctggggcc aggtgaaccg gctgcccttc    480

ttcaccaacc acttctttga tacatacctg ctgatcagcg aggacacgcc tgtgggttct    540

tctgtgaccc agttgctggc ccaagacatg gacaatgacc ccctggtgtt tggcgtgtct    600

ggggaggagg cctctcgctt ctttgcagtg gagcctgaca ctggcgtggt gtggctccgg    660

cagccactgg acagagagac caagtcagag ttcaccgtgg agttctctgt cagcgaccac    720

cagggggtga tcacacggaa ggtgaacatc caggttgggg atgtgaatga caacgcgccc    780

acatttcaca atcagcccta cagcgtccgc atccctgaga atacaccagt ggggacgccc    840

atcttcatcg tgaatgccac agaccccgac ttgggggcag ggggcagcgt cctctactcc    900

ttccagcccc cctcccaatt cttcgccatt gacagcgccc gcggtatcgt cacagtgatc    960

cgggagctgg actacgagac cacacaggcc taccagctca cggtcaacgc cacagatcaa   1020

gacaagacca ggcctctgtc caccctggcc aacttggcca tcatcatcac agatgtccag   1080

gacatggacc ccatcttcat caacctgcct tacagcacca acatctacga gcattctcct   1140

ccgggcacga cggtgcgcat catcaccgcc atagaccagg ataaaggacg tccccggggc   1200

attggctaca ccatcgtttc agggaatacc aacagcatct ttgccctgga ctacatcagc   1260

ggagtgctga ccttgaatgg cctgctggac cgggagaacc ccctgtacag ccatggcttc   1320

atcctgactg tgaagggcac ggagctgaac gatgaccgca ccccatctga cgctacagtc   1380

accacgacct tcaatatcct ggttattgac atcaatgaca atgccccgga gttcaacagc   1440

tccgagtaca gcgtggccat cactgagctg gcacaggtcg gctttgccct tccactcttc   1500

atccaggtgg tggacaagga tgagaatttg ggcctgaaca gcatgtttga ggtgtacttg   1560

gtggggaaca actcccacca cttcatcatc tccccgacct ccgtccaggg gaaggcggac   1620

attcgtattc gggtggccat cccactggac tacgagaccg tggaccgcta cgactttgat   1680

ctctttgcca atgagagtgt gcctgaccat gtgggctatg ccaaggtgaa gatcactctc   1740

atcaatgaaa atgacaaccg gcccatcttc agccagccac tgtacaacat cagcctgtac   1800

gagaacgtca ccgtggggac ctctgtgctg acagtcctgg tgagtccccg cttcactgca   1860

gggccactga gctctccagg gccgactgtg gtgaggcacc cagagggatt ttgtccaagg   1920

gacctcagca atcagggaag gaggcacccc caaatccctg agctgtgttt gttggtgtat   1980

taaataaagt ttttggactc ttaaaaaaaa aaaaaaaaaa aa                      2022


<210>  1680
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  1680

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Val Ser Pro Arg Phe Thr Ala Gly Pro Leu Ser Ser Pro 
                485                 490                 495     


Gly Pro Thr Val Val Arg His Pro Glu Gly Phe Cys Pro Arg Asp Leu 
            500                 505                 510         


Ser Asn Gln Gly Arg Arg His Pro Gln Ile Pro Glu Leu Cys Leu Leu 
        515                 520                 525             


Val Tyr 
    530 


<210>  1681
<211>  2438
<212>  DNA
<213>  Homosapiens

<400>  1681
ctcctttgtg cgatccgtcc cgagtccaca gtcgctcgcg gtcttggttg cagggaccct     60

aagtccgtag cctcgtctgg cttcacgggc cccgcagccc cgactgccct ggaccgtacc    120

acgactcctc aaggccccca gggctgtggc ttgggagccc cgtccaatgc gcggcccctt    180

tgctcggctc gggacatctc gccccaaaga aactcgcctc gccggggccc ctgggttacc    240

cgggactcgg ggctagggat agagggcgac tacactgcgc aagagatcgc aatgaagtcc    300

gtagatctcc aggctggagc cgcagagcga ggtggcgagg tggagaactc ggggctgggc    360

ctggacagcg gccctggggt cgtctggagt cctcgcgccc tcaacccgga aggcagcgga    420

ctgacatctg cgccgaagtc gcgcgtaccc cacggagggt cgggaccctg gaaatttcga    480

acgccccagc agttcagggc agtcatcgct tttcccaagc ccgggagtcc ggggccccgc    540

caggtttctc cgcgctgtga cctcgggcgc gcagagcgga gggcgccaag ctctctgctg    600

ggtgtcggag gacgcgccga aaacagggac gtctctgcag tgcgtccgac accagctctc    660

cagtcctgct gccgcccggg gttgctgcag cccgggttat cccggccccc caagctgccc    720

ggctttcggc ctcccctgct ccccgcgctg tggggtggcg gaggatggac ccaggctgac    780

gcgccgcgct gggctgggta cctggaaaga gggcccgcct cccggactcc gagtcgggca    840

cctgtgcgaa agaggcgaaa attcaggcct ggtgctcaag gctcagagat gaggagacct    900

ccccatcccc ccagattcct gccggcggtg ttggcgctca cctcctgatg gcctcgccct    960

gggtattccc cagcgttacg cgggcctgtg gatctaattt taattcattt gtaaaacaaa   1020

aggaccaacc cttcccgact tttggcggtg gaggaggctt gtaggttgag gccagcggtt   1080

cgatcgagga aagagtttgg gtttggggat taaagggccc atttgagtca gcgacttact   1140

ggtggtgcag cccctcggcc tcccagatcg tagttccaaa ttttatgtaa aacaactaat   1200

ttatggaaca atttaacaaa tggcagaaag aagtgagagt ccctctgttg ggacgttggc   1260

ctctcgcctt agaagtgaag ccccttcaga agtggtgggc gaaccgaagg catttcccaa   1320

gcagtcaaga gaaaagaaat accccaaaat ggttctttga ggtcggcttt tcggctggac   1380

tctgccccct tttccttccc cctttcccaa agatttctga ttcttgtcaa aggaatgcta   1440

gttgtggggg tcccaggtgc cttttacgaa gccgccctcc ccttccatcc ccgtcgttgc   1500

aggggcggtt gcggggtcaa cgggaagtac tcggggtggg acacgcctct tcttgctgag   1560

tctcaggtga acacagtctg ttgcttccac ccaaaagagc agccagtgcc acctgccact   1620

caacttagcg atttccagtg cccccctcag gggaaaccat gctgctgtcc gtaggtgtga   1680

ccagcttttt ggtgactacc tcttgaagaa agtgtctttc cctcagcaca tgtgtagcaa   1740

acaggacttg gatcctctcc ttatggtgca aacccatatc accgcctata gacacccact   1800

ttcctcccat aacacccttc cggagcttgc cagagggtct gggatgactc cacaccttca   1860

ggaattttga aacggctgct gattaggacg cagtttttga gtccgtgctt gatgaggatg   1920

tacagaggct gcacagctct gccttgaccc aaatcatccc agagagagtg cgaaggtggg   1980

agctgcagcc ggacccgcag ggccaccggc atggcaggtt ctgcaagagc ccgcctggcc   2040

gtccctgctt tctagcggct gatgtgaagt actggacaaa agcagctgct ccttgtcaag   2100

gatttccatt gtccaaggct gtgtacgtag aagacaccta ttttggtgga ataacacaat   2160

gatttgacag gaagaactaa ttttagctgc agttaactgc actactgtga gaataatatc   2220

agagatgttg aattttaaag aatagcttgg gtcatctttt gcaatgtaaa ggaatttttt   2280

caaaaaagac ggcagctcct tccacattct cttgaatttt aatagccttt ctttctgtaa   2340

atactataac tctgtaacac tcgtgagttt caggacctct aagaaaatca aatgaacctt   2400

cctgtaattt cctttaatta tactttacaa aaatcatt                           2438


<210>  1682
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  1682

Met Lys Ser Val Asp Leu Gln Ala Gly Ala Ala Glu Arg Gly Gly Glu 
1               5                   10                  15      


Val Glu Asn Ser Gly Leu Gly Leu Asp Ser Gly Pro Gly Val Val Trp 
            20                  25                  30          


Ser Pro Arg Ala Leu Asn Pro Glu Gly Ser Gly Leu Thr Ser Ala Pro 
        35                  40                  45              


Lys Ser Arg Val Pro His Gly Gly Ser Gly Pro Trp Lys Phe Arg Thr 
    50                  55                  60                  


Pro Gln Gln Phe Arg Ala Val Ile Ala Phe Pro Lys Pro Gly Ser Pro 
65                  70                  75                  80  


Gly Pro Arg Gln Val Ser Pro Arg Cys Asp Leu Gly Arg Ala Glu Arg 
                85                  90                  95      


Arg Ala Pro Ser Ser Leu Leu Gly Val Gly Gly Arg Ala Glu Asn Arg 
            100                 105                 110         


Asp Val Ser Ala Val Arg Pro Thr Pro Ala Leu Gln Ser Cys Cys Arg 
        115                 120                 125             


Pro Gly Leu Leu Gln Pro Gly Leu Ser Arg Pro Pro Lys Leu Pro Gly 
    130                 135                 140                 


Phe Arg Pro Pro Leu Leu Pro Ala Leu Trp Gly Gly Gly Gly Trp Thr 
145                 150                 155                 160 


Gln Ala Asp Ala Pro Arg Trp Ala Gly Tyr Leu Glu Arg Gly Pro Ala 
                165                 170                 175     


Ser Arg Thr Pro Ser Arg Ala Pro Val Arg Lys Arg Arg Lys Phe Arg 
            180                 185                 190         


Pro Gly Ala Gln Gly Ser Glu Met Arg Arg Pro Pro His Pro Pro Arg 
        195                 200                 205             


Phe Leu Pro Ala Val Leu Ala Leu Thr Ser 
    210                 215             


<210>  1683
<211>  2778
<212>  DNA
<213>  Homosapiens

<400>  1683
taaaagcgca gcaaggcggg ctggcagaac tccatccgcc acaacctgtc gctcaacgac     60

tgcttcaaga aggtgccccg cgacgaggac gacccaggta aaggcaatta ctggaccctg    120

gaccccaact gcgagaagat gtttgacaac gggaacttcc gaaggaagag gaagaggaga    180

gctgaagcca gcgcggccgt gcgctcggga gccaggagcg tgggaggggc cgaggcgcca    240

gcgctggagc ccccgagcgc ggcttgcctg gacctgcagg cctcgccctc tccatccgca    300

cccgaggccg ccacctgctt ctccggtttc gcttctgcta tgagcgctct ggctggcggc    360

cttggcacct tccccggggg cctggcgggc gacttttctt tcgggaggcg gccaccgaca    420

gtcgccaccc acgctcccca gacccttaac ccctcccctg gcttcgcccc tggccaccag    480

accgcggccg ccggcttccg cctcagtcac ctcctctaca gccgggaagg gaccgaagtt    540

tgaagggagg ctggaggcta gccgggtgcg ggtccagagg tgctgagctc aggcctccgg    600

tttcccctgg tgacagcccc acgtgttggc gttgaaggcc ttggtgccct gggaggaagc    660

gcagagccgg gggcggctcg gccagcaggg agctgggctg agcggctctt gggctttggg    720

gtgggtggcc cttctgctgt gcacccctca cccaggcgac cttcggagcc tccctgctct    780

gcctctaagt ccagccgccc tgggcgtcta gaacctgtgc tctcgaggga tttgccttga    840

aggggcggcg ggtcggccct cagctccagc gttttccaag gaggctggct gactccaaag    900

agccttagag cagatgggaa gaaggtgggc tgccagagcg gcccaggtgg tgggggccct    960

ttccacctcc acccagcttg gcccacctgg ctcagggcct tcccttctgc ttcagggaag   1020

ctgccgcagg ggctggggga cagagctcag gagcagctgc agtgggctcc aggtgggcca   1080

ggagcctgca gtgaggggat ctgagacagt tggcattggg tcctgtgtaa ggaaggtctt   1140

gctaatggtt ggaactgctg gtggtgggag ggagaagcac tgcgtgggca gaaagcgccc   1200

ttgggatacc agctcccttc cctgtcactc agccctggtc cttgatgacc cccctctagg   1260

acagggcaac tccccagggc cccgccacca ctgaccacag gagcggtgcc cagcacccag   1320

gagttcccca agggtccagg tttgtgccac ccacacccac actcacaccc acactcacac   1380

tcacactcac acccacaccc acacccacac ccacactcac acccacactc acactcacac   1440

ccacactcac acccacaccc acacccacac ccacacccac actcacacac actcacaccc   1500

acaccacact cacacccaca cacactcaca cccacacaca cccacactca tactcacacc   1560

cacactcaca ccacacccac actcacactg acacccacac tcacacccac actcacactg   1620

acacccacac tcacacccac actcacactc acactcacac ccacactcac actcacaccc   1680

acactcacac tcacacccac actcacacca cactcacacc cacacacacc cacactcata   1740

cactcacacc cacactcata ctgacacacc cacacccaca ctcacaccca cacccacact   1800

cacacccaca ctcacacagg ctcatggaag gccacacttg ttttggtctc tttcccctcc   1860

aaacccacag tttgagccaa agctgtgcgt gtgttcagag ctcctgaaca gcagcctccc   1920

gtgtaaattg aaccctgccc cacccagttc cttcttaggg atggtatctt tgtgaaggac   1980

aaggagcccc cagtcactgg gaagaggaat tttttggcct ctgtactcct tagaggacct   2040

aagtgcccca gtcagatgcc ctgagtcttt gtggcatctg ggactccctg gagatggaga   2100

cgttggtggg gggggggtac ccaccttgtt gttgatgggg gtacctatct tccctgcatt   2160

ttgggggagg gtgggagggg tccttcccag gaagagagtg gagacaggtt actgttactt   2220

tggagtggga caggctggtt tagcaatcct aagccccagc cacgcaggta ttcctgatct   2280

gcctgcaggg cccctcactg cagctgccac cagtgctgga aatgagagca gggctcctga   2340

ctgtccctag agctgactca tcatggccct gctgaagagt gaggtgtgtg tgtgtgtgtg   2400

cgtgtgtgcg taagacagag agggagggag aaggaaggag gcgggggaac atggagagaa   2460

ggagccagga gttgggataa acctggcccc tggtcatatg tttcatcagc agtggctcct   2520

aactccacgt gccatctctg ctgctgccct ccacaagcag gtgagcagag tgccagttgt   2580

gttgaaggtg atgatgtcgc ctaactaaac tcacaaccaa cccgcaatct ctcttggggg   2640

gacactcccc ataagcaata caattaaaga agaccaggaa aggaaaataa attccttagc   2700

ttatacattt aaaaagtatc ccttgaacct attttaatag aatgaaatgc taaaaataaa   2760

gaccaatata acatacat                                                 2778


<210>  1684
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  1684

Met Phe Asp Asn Gly Asn Phe Arg Arg Lys Arg Lys Arg Arg Ala Glu 
1               5                   10                  15      


Ala Ser Ala Ala Val Arg Ser Gly Ala Arg Ser Val Gly Gly Ala Glu 
            20                  25                  30          


Ala Pro Ala Leu Glu Pro Pro Ser Ala Ala Cys Leu Asp Leu Gln Ala 
        35                  40                  45              


Ser Pro Ser Pro Ser Ala Pro Glu Ala Ala Thr Cys Phe Ser Gly Phe 
    50                  55                  60                  


Ala Ser Ala Met Ser Ala Leu Ala Gly Gly Leu Gly Thr Phe Pro Gly 
65                  70                  75                  80  


Gly Leu Ala Gly Asp Phe Ser Phe Gly Arg Arg Pro Pro Thr Val Ala 
                85                  90                  95      


Thr His Ala Pro Gln Thr Leu Asn Pro Ser Pro Gly Phe Ala Pro Gly 
            100                 105                 110         


His Gln Thr Ala Ala Ala Gly Phe Arg Leu Ser His Leu Leu Tyr Ser 
        115                 120                 125             


Arg Glu Gly Thr Glu Val 
    130                 


<210>  1685
<211>  1174
<212>  DNA
<213>  Homosapiens

<400>  1685
aatgtccatt agcataaccc ttcctcagga agagtgagat tttatatttg acaataaagt     60

gttagactcc atttctaaat accagacttc aaaagataag gttcaaaagt gttataagaa    120

gatattcctt tttttgtcct agagaactta ttttcctgtg aaaatgccta ccacaaagaa    180

gacattgatg ttcttatcaa gctttttcac cagccttggg tccttcattg taatttgctc    240

tattcttggg acacaagcat ggatcaccag tacgattgct gttagagact ctgcttcaaa    300

tgggagcatt ttcatcactt acggactttt tcgtggggag agtagtgaag aattgagtca    360

cggacttgca gaaccaaaga aaaagtttgc agttttagag atactgaata attcttccca    420

aaaaactctg cattcggtga ctatcctgtt cctggtcctg agtttgatca cgtcgctgct    480

gagctctggg tttaccttct acaacagcat cagcaaccct taccagacat tcctggggcc    540

gacgggggtg tacacctgga acgggctcgg tgcatccttc gtttttgtga ccatgatact    600

gtttgtggcg aacacgcagt ccaaccaact ctccgaagag ttgttccaaa tgctttaccc    660

ggcaaccacc agtaaaggaa cgacccacag ttacggatac tcgttctggc tcatactgct    720

cgtcattctt ctaaatatag tcactgtaac catcatcatt ttctaccaga aggccagata    780

ccagcggaag caggagcaga gaaagccaat ggaatatgct ccaagggacg gaattttatt    840

ctgaattctc tttcatctca ttttggcgtt gcatctattg tacatcagcc ctgagtagta    900

actggttagc ttctctggac aattcagcat ggtaacgtga ctgtcatctg tgacagcatt    960

tgtgtttcat gacactgtgt tcttcattga tgctgtactc ctgaaaattt ttcccacaag   1020

gttggggaaa tgaatgggaa atgtcgctgg tctgtgtggt attcaaagca gtagtatcat   1080

gatgagcgta acgacccttc tggcctggtc tcacgatctg aaataataaa aggctgtgtc   1140

atgcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               1174


<210>  1686
<211>  226
<212>  PRT
<213>  Homosapiens

<400>  1686

Met Pro Thr Thr Lys Lys Thr Leu Met Phe Leu Ser Ser Phe Phe Thr 
1               5                   10                  15      


Ser Leu Gly Ser Phe Ile Val Ile Cys Ser Ile Leu Gly Thr Gln Ala 
            20                  25                  30          


Trp Ile Thr Ser Thr Ile Ala Val Arg Asp Ser Ala Ser Asn Gly Ser 
        35                  40                  45              


Ile Phe Ile Thr Tyr Gly Leu Phe Arg Gly Glu Ser Ser Glu Glu Leu 
    50                  55                  60                  


Ser His Gly Leu Ala Glu Pro Lys Lys Lys Phe Ala Val Leu Glu Ile 
65                  70                  75                  80  


Leu Asn Asn Ser Ser Gln Lys Thr Leu His Ser Val Thr Ile Leu Phe 
                85                  90                  95      


Leu Val Leu Ser Leu Ile Thr Ser Leu Leu Ser Ser Gly Phe Thr Phe 
            100                 105                 110         


Tyr Asn Ser Ile Ser Asn Pro Tyr Gln Thr Phe Leu Gly Pro Thr Gly 
        115                 120                 125             


Val Tyr Thr Trp Asn Gly Leu Gly Ala Ser Phe Val Phe Val Thr Met 
    130                 135                 140                 


Ile Leu Phe Val Ala Asn Thr Gln Ser Asn Gln Leu Ser Glu Glu Leu 
145                 150                 155                 160 


Phe Gln Met Leu Tyr Pro Ala Thr Thr Ser Lys Gly Thr Thr His Ser 
                165                 170                 175     


Tyr Gly Tyr Ser Phe Trp Leu Ile Leu Leu Val Ile Leu Leu Asn Ile 
            180                 185                 190         


Val Thr Val Thr Ile Ile Ile Phe Tyr Gln Lys Ala Arg Tyr Gln Arg 
        195                 200                 205             


Lys Gln Glu Gln Arg Lys Pro Met Glu Tyr Ala Pro Arg Asp Gly Ile 
    210                 215                 220                 


Leu Phe 
225     


<210>  1687
<211>  2394
<212>  DNA
<213>  Homosapiens

<400>  1687
cgggagatcc agaagtgaaa cgccaggctc tctggaggcc aggagatgac tctgttgacg     60

ttcagggatg tggccataga attctccctg gaggagtgga aatgcctgga cctcgctcag    120

cagaatttgt acagggatgt gatgttggag aactacagaa acttgttctc cgttggtctc    180

actgtctgta agccaggcct gatcacctgc ctggagcaac gaaaagagcc ctggaatgtg    240

aagagacagg aggcagcaga cggacatcca gagatgggat ttcaccatgc tactcaggct    300

tgtcttgaac tcctgggctc aagcgatctg cctgcctcag cctcccaaag tgctgggatt    360

acaggtgtga accaccgtgc ccagccaggc ctcaatgttt ctgtggacaa attcactgca    420

ctgtgctcac ctggggtgct gcaaactgtg aaatggtttt tagagttcag atgcatcttc    480

tcactagcta tgtcttctca ttttacccaa gaccttctgc cagagcaggg catacaagat    540

gcattcccaa aaagaatact gagaggatat ggaaattgtg gccttgataa tttatattta    600

aggaaagact gggaaagttt agatgagtgt aagttgcaaa aagattataa tggacttaac    660

caatgttcat caactaccca tagcaaaatc tttcaatata ataaatatgt taaaatcttt    720

gataactttt caaatttaca tagacgtaat ataagtaata ctggagagaa acctttcaaa    780

tgtcaagaat gtggcaaatc ctttcaaatg ctctcattcc taactgaaca tcagaaaatt    840

cacactggaa aaaaattcca aaaatgtgga gaatgtggca aaacctttat ccagtgctca    900

cactttactg aacctgagaa cattgacact ggagagaaac cttacaagtg tcaagaatgt    960

aacaacgtca ttaaaacttg ctcagtcctt actaaaaata gaatttatgc cggaggggaa   1020

cattacagat gtgaagaatt tggcaaagta tttaaccagt gctcccacct tactgaacat   1080

gagcatggta ctgaggaaaa accctgcaaa tatgaagagt gcagcagtgt ctttatctct   1140

tgctcaagcc tttctaatca acagatgatt cttgctggag agaagctctc caaatgtgaa   1200

acatggtaca aaggttttaa ccacagccca aatccttcca aacaccagag aaatgagatt   1260

ggagggaaac ctttcaaatg tgaggaatgt gacagcatct tcaagtggtt ctcagacctt   1320

actaaacata agagaattca cactggtgag aaaccataca aatgtgacga atgtgggaaa   1380

gcctatacac agtcctcaca cctcagtgaa cacaggagga ttcacaccgg agagaaaccc   1440

taccaatgtg aagaatgtgg gaaggtcttc agaacttgct caagcctttc taaccataag   1500

agaactcatt ctgaagaaaa accctacacg tgtgaagaat gtggcaacat ctttaagcag   1560

ttatcagacc tcactaagca taagaaaacc catactggag agaagcccta caaatgtgac   1620

gaatgtggaa aaaactttac ccagtcctcc aaccttattg tacataagag aattcatact   1680

ggagagaaac cctacaagtg tgaagaatgt ggcagagcct tcatgtggtt ctcagacatt   1740

accaaacata agcaaaccca tactggagag aaaccctaca aatgtgacga atgtggcaaa   1800

aactttaccc agtcctcaaa ccttattgta cataagagaa ttcatactgg agagaaaccc   1860

tacaagtgtg aaaagtgtgg caaagccttc acccagttct cacacctgac tgtacatgaa   1920

agcattcata cttgagaaaa aaataaacaa atataaaaat aggcaaagcc gttagtatct   1980

gctcgcatcc cactttacat cagagttcag acttaataaa gttatcataa atgtaattac   2040

tattgaaaga cctttcatga aatataagtc tccagagcac acaagagtat ttcttctgaa   2100

aaaaatgtta caattatact agatggaaga cttgcatcag ttgcttaaac tttcagaaaa   2160

tttgtagaga aacccaacaa atctcataaa tgtggaataa catttgttca aaaatgatag   2220

cttagaaaac actagagttc atactaaaag atattttgca aatacactaa atggaaaaat   2280

aagcaaaatc caatttaagt aaacaatgga ggatttgaag gagaaaggaa tagagcacgg   2340

acacgttcag aaatgacact gaatccctgt gttgagtcta cagagacatc taga         2394


<210>  1688
<211>  629
<212>  PRT
<213>  Homosapiens

<400>  1688

Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser 
        115                 120                 125             


Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile 
    130                 135                 140                 


Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu 
145                 150                 155                 160 


Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly 
                165                 170                 175     


Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu 
            180                 185                 190         


Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser 
        195                 200                 205             


Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile 
    210                 215                 220                 


Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly 
225                 230                 235                 240 


Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu 
                245                 250                 255     


Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln 
            260                 265                 270         


Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr 
        275                 280                 285             


Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu 
    290                 295                 300                 


Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile 
305                 310                 315                 320 


Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe 
                325                 330                 335     


Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys 
            340                 345                 350         


Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser 
        355                 360                 365             


Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys 
    370                 375                 380                 


Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His 
385                 390                 395                 400 


Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp 
                405                 410                 415     


Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr 
        435                 440                 445             


Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys 
    450                 455                 460                 


Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser 
465                 470                 475                 480 


Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys 
                485                 490                 495     


Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His 
            500                 505                 510         


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        515                 520                 525             


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
    530                 535                 540                 


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Ala Phe Met 
545                 550                 555                 560 


Trp Phe Ser Asp Ile Thr Lys His Lys Gln Thr His Thr Gly Glu Lys 
                565                 570                 575     


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
            580                 585                 590         


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        595                 600                 605             


Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His 
    610                 615                 620                 


Glu Ser Ile His Thr 
625                 


<210>  1689
<211>  768
<212>  DNA
<213>  Homosapiens

<400>  1689
ggctgtgacc gtctatgaca agccagcatc tttctttcaa gagacctctg gacctgcagc     60

accaactctt catgaagctg ggcggcacgc actctccgtt cagggcctgc tcagaacctg    120

aggacccaga cacggagcgg tcggccttca tggagcggga tgctgggagc gggctggtga    180

tgcgcctccg cgagcggcca gccctgctgg tcagcagcac aggctggaca gagtttgaac    240

aactgactct tgatggacac aaccttcctt ctctcgtctg tgtgataaca gggtcggtgg    300

atctgggtgt ctgtctgcac acgtcctgca gtggcctgga cctgcccatg aaggtggtgg    360

acatgttcgg gtgctgtttg cctgtgtgtg ccgtgaactt caagtgttta catgagctgg    420

tgaaacatga agaaaatggc ctggtctttg aggactcaga ggaactggca gctctgcagg    480

tgcttttctc aaactttcct gatcctgcgg gcaagctaaa ccagttccgg aagaacctgc    540

gggagtcgca gcagctccga tgggattaga gctgggtgca gactgtgctc cctttggtta    600

tggacacata actcctgggc cagaggctaa aaccccggga cccctgctgt ccttcccaca    660

gcttcttctc agagtctcag ggcaaatcct ttcgagcagc gcctcccagt ggccagaagc    720

tgaaatgatg gcagtagtgc cacctggtga atgaattggt tctgtgac                 768


<210>  1690
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  1690

Met Thr Ser Gln His Leu Ser Phe Lys Arg Pro Leu Asp Leu Gln His 
1               5                   10                  15      


Gln Leu Phe Met Lys Leu Gly Gly Thr His Ser Pro Phe Arg Ala Cys 
            20                  25                  30          


Ser Glu Pro Glu Asp Pro Asp Thr Glu Arg Ser Ala Phe Met Glu Arg 
        35                  40                  45              


Asp Ala Gly Ser Gly Leu Val Met Arg Leu Arg Glu Arg Pro Ala Leu 
    50                  55                  60                  


Leu Val Ser Ser Thr Gly Trp Thr Glu Phe Glu Gln Leu Thr Leu Asp 
65                  70                  75                  80  


Gly His Asn Leu Pro Ser Leu Val Cys Val Ile Thr Gly Ser Val Asp 
                85                  90                  95      


Leu Gly Val Cys Leu His Thr Ser Cys Ser Gly Leu Asp Leu Pro Met 
            100                 105                 110         


Lys Val Val Asp Met Phe Gly Cys Cys Leu Pro Val Cys Ala Val Asn 
        115                 120                 125             


Phe Lys Cys Leu His Glu Leu Val Lys His Glu Glu Asn Gly Leu Val 
    130                 135                 140                 


Phe Glu Asp Ser Glu Glu Leu Ala Ala Leu Gln Val Leu Phe Ser Asn 
145                 150                 155                 160 


Phe Pro Asp Pro Ala Gly Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg 
                165                 170                 175     


Glu Ser Gln Gln Leu Arg Trp Asp 
            180                 


<210>  1691
<211>  2895
<212>  DNA
<213>  Homosapiens

<400>  1691
atgtcgtggg ggactggtga ctcctcggtg gaaaatcggg gactgtcatt ggagaggagc     60

gatagaagaa aggctgaagc agtgaaatgt atctcctgca ccagcctggg cctcgatgtc    120

ttgagtactg atgacccact cctgctgtgg ggctgggtca tctgccagct ctccaaggag    180

ctggcgggaa accgctgcaa tcagagcgaa cccagggccc gggcagcctg tgtggagatt    240

gctgcattca cctttaatat ggctaaaatg ttttccttca atgacagtaa tgctgccaga    300

atccatcaag acacccagga actgatgtgc tttggcagat ggtgctggaa agatgggatt    360

cccggcagcc tttgcatccc ttgctcacag cccacgagca tctccactgt ccagcagggg    420

aagaaagcag catcatccca ctattccagg ggaggtgcta aatacgaggg tgaggctgtc    480

aagcggtccc tggtggagtc ctacactcac ccaaacagca acgagacaga gcggagggag    540

aacatcgata ccgtcatgaa ctgcttcagc acagaagact ttgactttgt gactctgtac    600

tacagagagc cagataacgt gggacatcga ttcgggccag aggcagagaa gaggaagttg    660

atgattcagc aaatcggcag gaccatcgtg tatctgttca gggtctgggt caagtttgat    720

attgcgggct acggtggctt tgggctgccc ctacccaaat tggggcaaga ggaagccctt    780

taccaggcac tgaagaatgc gcaccctcac ctccaggtct acaagaagga ggagtttcca    840

gaacacttcc atctcgctaa acatgaccgg gttctgccaa tcgtgatttt tcagagaatt    900

ataatgtgtt tcagcaaagg cagccatggc tttgataatg tcctcatgga catgaacatc    960

atattcagag ctttcgggcc agatttcaag aggaatcgcc tggccgatcc ttttaacagc   1020

atccacatct acccattcgt gtctttggag ccccaggaac aagatgtcaa cagctccata   1080

cagatagcac gggaggtagg gaatccctcg acctgctggc ggaggaactg cgagagtgcc   1140

tacgttggcc caaggcctga ccggacgatc ccggggaccc tcgccctaac cggccccgac   1200

tcccgggccc caaacccgga ctcggccccg cctgaagctc cggatcctgg ggcccgtccc   1260

tggctccgcg tcggcagacc gtgggctcgc tcctgggcct gcctcaaact ctccgcagag   1320

tccgagcagc gcctggccac gtgctacgac atagtcaacg ccccgccctg gccccgcctc   1380

ctgagccgtt ctccgggccc cgccccctct ctgcccccgc gcactgccct gggcccgccc   1440

ccttttcagt ccaggctcgg cttccgcccg gtctcccggc aacgctgcgg ccccgccccc   1500

gtcatggtgc ccgaggagaa cgcggggacc gaactcttgc tgcagagttt cgagcgccgc   1560

ttcctggcgg cgcgcgcact gcgttccttc ccctggcaga gcttagaagc aaagttaaga   1620

gactcatcag attctgagct tctgcgggat attttgcaga agactgtgaa gcatcctgtg   1680

tgtgtgaagc accggctgtc agtcaagtat gcccggtgct ttctctcaga actcaccaaa   1740

aagcacgagg ctgtccacac agagcttttg gacaagctgt acgaggacct ggcagagacc   1800

ctgatggcca aggagtccac ccagggccac ccgagctatt tgctgccctc gggaggctca   1860

gtcacactct ccgagagcac agccatcatc tcccatggca tcacaggcct ggtcacatga   1920

gatgctgccc tctacctggc agaatgggcc atcgagaacc cggcagcctt ctctcatagg   1980

actgtcctag agcttggcag tggcgccagc ctcacaggcc tggccatctg caagatgtgc   2040

cgcctccagg catacatctt cagcgactgt cacagccagg tcctcgagaa gctccgaggg   2100

aatgtccttc tcaatggcct ctcattagag gcagacatct ctgccaactt agacagcccc   2160

agggtgacag tggcccagct ggactgggac gtcgcgacgg tccatcagct ctctgccatc   2220

cagccagatg ttgtcattgc agcagacgtg ctgtattgcc cagaatccat cgtgtcgctg   2280

gtcgcggtcc tgcggaggct ggctgcctac cgggagcacc agcgggctcc tcaagtctac   2340

gtggccctta tcgtccgcaa cccagagacg tgccagctgt tcaccaccga gctatgccgg   2400

gccgggatca gatgggaagt ggaacctcgt catgaccaga aactgtttcc ctacgaagag   2460

cacttggaga tggcaatgct gaacctcaca ctgtaggact cacacacgac tccaacggga   2520

ttgtgagaat caagtcactc tcgtgggaag agtttttata tgggaaagcg gataaaactt   2580

tcattggact ggaatgtttg gagaatgtta atttccaaat caggaaccac aaactgccct   2640

ctgataagac atcggctatc taagcttgtg ggtgctccct ttctgccagc agttctggtt   2700

cttaagaaaa tcgccatcaa tcagacatga aaactctggc tccaaaaata gcattttctt   2760

tgtgcaaata aaaacgtgtg tatcaagtat gatgttcccc ccaacgtgga cacactcggt   2820

tcctcacaaa gccaagcccg ctgcagctgc cacatccctg ggcttatggt gcagcaggtg   2880

cttttttcaa gacag                                                    2895


<210>  1692
<211>  639
<212>  PRT
<213>  Homosapiens

<400>  1692

Met Ser Trp Gly Thr Gly Asp Ser Ser Val Glu Asn Arg Gly Leu Ser 
1               5                   10                  15      


Leu Glu Arg Ser Asp Arg Arg Lys Ala Glu Ala Val Lys Cys Ile Ser 
            20                  25                  30          


Cys Thr Ser Leu Gly Leu Asp Val Leu Ser Thr Asp Asp Pro Leu Leu 
        35                  40                  45              


Leu Trp Gly Trp Val Ile Cys Gln Leu Ser Lys Glu Leu Ala Gly Asn 
    50                  55                  60                  


Arg Cys Asn Gln Ser Glu Pro Arg Ala Arg Ala Ala Cys Val Glu Ile 
65                  70                  75                  80  


Ala Ala Phe Thr Phe Asn Met Ala Lys Met Phe Ser Phe Asn Asp Ser 
                85                  90                  95      


Asn Ala Ala Arg Ile His Gln Asp Thr Gln Glu Leu Met Cys Phe Gly 
            100                 105                 110         


Arg Trp Cys Trp Lys Asp Gly Ile Pro Gly Ser Leu Cys Ile Pro Cys 
        115                 120                 125             


Ser Gln Pro Thr Ser Ile Ser Thr Val Gln Gln Gly Lys Lys Ala Ala 
    130                 135                 140                 


Ser Ser His Tyr Ser Arg Gly Gly Ala Lys Tyr Glu Gly Glu Ala Val 
145                 150                 155                 160 


Lys Arg Ser Leu Val Glu Ser Tyr Thr His Pro Asn Ser Asn Glu Thr 
                165                 170                 175     


Glu Arg Arg Glu Asn Ile Asp Thr Val Met Asn Cys Phe Ser Thr Glu 
            180                 185                 190         


Asp Phe Asp Phe Val Thr Leu Tyr Tyr Arg Glu Pro Asp Asn Val Gly 
        195                 200                 205             


His Arg Phe Gly Pro Glu Ala Glu Lys Arg Lys Leu Met Ile Gln Gln 
    210                 215                 220                 


Ile Gly Arg Thr Ile Val Tyr Leu Phe Arg Val Trp Val Lys Phe Asp 
225                 230                 235                 240 


Ile Ala Gly Tyr Gly Gly Phe Gly Leu Pro Leu Pro Lys Leu Gly Gln 
                245                 250                 255     


Glu Glu Ala Leu Tyr Gln Ala Leu Lys Asn Ala His Pro His Leu Gln 
            260                 265                 270         


Val Tyr Lys Lys Glu Glu Phe Pro Glu His Phe His Leu Ala Lys His 
        275                 280                 285             


Asp Arg Val Leu Pro Ile Val Ile Phe Gln Arg Ile Ile Met Cys Phe 
    290                 295                 300                 


Ser Lys Gly Ser His Gly Phe Asp Asn Val Leu Met Asp Met Asn Ile 
305                 310                 315                 320 


Ile Phe Arg Ala Phe Gly Pro Asp Phe Lys Arg Asn Arg Leu Ala Asp 
                325                 330                 335     


Pro Phe Asn Ser Ile His Ile Tyr Pro Phe Val Ser Leu Glu Pro Gln 
            340                 345                 350         


Glu Gln Asp Val Asn Ser Ser Ile Gln Ile Ala Arg Glu Val Gly Asn 
        355                 360                 365             


Pro Ser Thr Cys Trp Arg Arg Asn Cys Glu Ser Ala Tyr Val Gly Pro 
    370                 375                 380                 


Arg Pro Asp Arg Thr Ile Pro Gly Thr Leu Ala Leu Thr Gly Pro Asp 
385                 390                 395                 400 


Ser Arg Ala Pro Asn Pro Asp Ser Ala Pro Pro Glu Ala Pro Asp Pro 
                405                 410                 415     


Gly Ala Arg Pro Trp Leu Arg Val Gly Arg Pro Trp Ala Arg Ser Trp 
            420                 425                 430         


Ala Cys Leu Lys Leu Ser Ala Glu Ser Glu Gln Arg Leu Ala Thr Cys 
        435                 440                 445             


Tyr Asp Ile Val Asn Ala Pro Pro Trp Pro Arg Leu Leu Ser Arg Ser 
    450                 455                 460                 


Pro Gly Pro Ala Pro Ser Leu Pro Pro Arg Thr Ala Leu Gly Pro Pro 
465                 470                 475                 480 


Pro Phe Gln Ser Arg Leu Gly Phe Arg Pro Val Ser Arg Gln Arg Cys 
                485                 490                 495     


Gly Pro Ala Pro Val Met Val Pro Glu Glu Asn Ala Gly Thr Glu Leu 
            500                 505                 510         


Leu Leu Gln Ser Phe Glu Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg 
        515                 520                 525             


Ser Phe Pro Trp Gln Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp 
    530                 535                 540                 


Ser Glu Leu Leu Arg Asp Ile Leu Gln Lys Thr Val Lys His Pro Val 
545                 550                 555                 560 


Cys Val Lys His Arg Leu Ser Val Lys Tyr Ala Arg Cys Phe Leu Ser 
                565                 570                 575     


Glu Leu Thr Lys Lys His Glu Ala Val His Thr Glu Leu Leu Asp Lys 
            580                 585                 590         


Leu Tyr Glu Asp Leu Ala Glu Thr Leu Met Ala Lys Glu Ser Thr Gln 
        595                 600                 605             


Gly His Pro Ser Tyr Leu Leu Pro Ser Gly Gly Ser Val Thr Leu Ser 
    610                 615                 620                 


Glu Ser Thr Ala Ile Ile Ser His Gly Ile Thr Gly Leu Val Thr 
625                 630                 635                 


<210>  1693
<211>  400
<212>  DNA
<213>  Homosapiens

<400>  1693
ggtgaaatgg gcagagtgac gcttacctgg gatggcagtg aagtgggatg gggaggtcat     60

tgtgacaagg ggcggcatga ggtacttggc cttgacgccc tccccggcca gacggtccag    120

gttgggggtg tccacatcct gatcctagtc ccagcggaag ccctggaagg agatcagcag    180

cagttaaact cctggagggc agagctgtgt ctgccatctt catcattgca ttaccaccac    240

ccagcacagt gcctggcaca aaagagttgc tcaataaata aatcaggatg aatggataaa    300

tacatggata ggcactttga actacagatg agtttaaata ctttgtgttt ttcttagtca    360

aacatgtgca attaagcatg tgataaatga tatgatgacc                          400


<210>  1694
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  1694

Met Gly Arg Val Thr Leu Thr Trp Asp Gly Ser Glu Val Gly Trp Gly 
1               5                   10                  15      


Gly His Cys Asp Lys Gly Arg His Glu Val Leu Gly Leu Asp Ala Leu 
            20                  25                  30          


Pro Gly Gln Thr Val Gln Val Gly Gly Val His Ile Leu Ile Leu Val 
        35                  40                  45              


Pro Ala Glu Ala Leu Glu Gly Asp Gln Gln Gln Leu Asn Ser Trp Arg 
    50                  55                  60                  


Ala Glu Leu Cys Leu Pro Ser Ser Ser Leu His Tyr His His Pro Ala 
65                  70                  75                  80  


Gln Cys Leu Ala Gln Lys Ser Cys Ser Ile Asn Lys Ser Gly 
                85                  90                  


<210>  1695
<211>  1798
<212>  DNA
<213>  Homosapiens

<400>  1695
ccagcgctga gccccactgg gtgaaggcaa tgcctgtcat gttcaccaca atatcccctc     60

ccccatcacc acgcctggtc cacagtgatg ctcaaaaaag atctgttggt agcaaagaga    120

aggtgcattc gtgtcatcct gcaggcggaa ttctccacga gtttggagca gcctcggttt    180

tcccaccacc tccaaatcat ggaagacaca gggtaagagc aaagacaagg tggctgtggc    240

cgatgtccac cctctcgggg cttcccttct cttctctcct ccttggggag ggagaccatc    300

ggggtgcaac ctggctgcag cggggaggag gggcagggcc tggtcagagc gggtatggcc    360

acaggcaggg gacagcgacc gcttgggccg gggcaggtga gcgcagcgca ggccagggcc    420

cggcgtgtcc gcggtgcgcg cgagcggcca gcagagggcg ccagagagcc aggagcggcc    480

cgcggaggag ccagcgcccg ccccgatgcc cagctccgcg ccgcgcggac ccaccgagcc    540

cgcgctcaga cgccccagct ccgccgagag gccgctcgcg ccgggtcctt cctcttcccc    600

aggtgcaggc agaacccccg gagccatggc cagcccttcc ggcagctccg aagccactgg    660

caagccccga ggcagggatg gccggcccag gagggaggag gacgacgtcc ctcccgagga    720

gaagaggctg cggctgttgc tggagggggg aagcgcacag cccgaggacg gggaggacgc    780

gccgcggccg ggcaggaagg agaccggcac ccagacaggt ggcgacggca gaggagtaag    840

tgacgcgggc gctggggtcc gggggtcccg ggggcgcagg gtaggggcgg cgggaggctc    900

cgtggccggc cccgggttga agttgggaga gcggccttca ttctgaaccc atttaggcag    960

cacgggcagc cctcctcgcc gtgggcggca ttagagccca ccctgcccag tcttggggtt   1020

gctccttgat gctgtctggg aggcttgctc atggtgacat ccttatctct ccgtgcacgt   1080

taccgcattc agagcttggg tcacgtggac actgaactca ggcgaatttt ctctgagatc   1140

ccgggagaag gaggacagtt ctttggaagg ttttccaggg ctgatcacgg aaaggatgag   1200

aagggagagg tcctggtcgg ggacacaatt acgatggcag tgtaacgccg ggaaacttta   1260

ttgcatgaag tccctctcac tccctctacc tccttctttt acgtggactc tgccaaagac   1320

caggatacca gaatgcagtg gagtgaccaa gtgtagtggg accttgggaa cccgagtctg   1380

gagccaggca gctggggttt gcatcctggt tctgcccctc cttagctggc tgacatggca   1440

caagccactt accctctctg agccttactg tcttcggtgg caaatggatc tgtcaacagg   1500

ccccattgcc tggggttgtt actgctgaga ttaagggaag ctcatccata gaagcactta   1560

gcgttgtgcc tggcacatag tgtatggtgg ataaatggga attaggactg aaactcatgc   1620

cttggtgtgt ttttgcagtg atgttttgtt ctggggtgca tcacaagaga caaagttctt   1680

ggctgggcat ggtggcttaa gccaataatc ccagcacttt gagaggccga aaggggagga   1740

tcgcttcagc ccaggagttt aagaccagct gggcaacata gtgaagcctc atatctac     1798


<210>  1696
<211>  162
<212>  PRT
<213>  Homosapiens

<400>  1696

Met Ala Thr Gly Arg Gly Gln Arg Pro Leu Gly Pro Gly Gln Val Ser 
1               5                   10                  15      


Ala Ala Gln Ala Arg Ala Arg Arg Val Arg Gly Ala Arg Glu Arg Pro 
            20                  25                  30          


Ala Glu Gly Ala Arg Glu Pro Gly Ala Ala Arg Gly Gly Ala Ser Ala 
        35                  40                  45              


Arg Pro Asp Ala Gln Leu Arg Ala Ala Arg Thr His Arg Ala Arg Ala 
    50                  55                  60                  


Gln Thr Pro Gln Leu Arg Arg Glu Ala Ala Arg Ala Gly Ser Phe Leu 
65                  70                  75                  80  


Phe Pro Arg Cys Arg Gln Asn Pro Arg Ser His Gly Gln Pro Phe Arg 
                85                  90                  95      


Gln Leu Arg Ser His Trp Gln Ala Pro Arg Gln Gly Trp Pro Ala Gln 
            100                 105                 110         


Glu Gly Gly Gly Arg Arg Pro Ser Arg Gly Glu Glu Ala Ala Ala Val 
        115                 120                 125             


Ala Gly Gly Gly Lys Arg Thr Ala Arg Gly Arg Gly Gly Arg Ala Ala 
    130                 135                 140                 


Ala Gly Gln Glu Gly Asp Arg His Pro Asp Arg Trp Arg Arg Gln Arg 
145                 150                 155                 160 


Ser Lys 
        


<210>  1697
<211>  297
<212>  DNA
<213>  Homosapiens

<400>  1697
atggcggcgg cagctgtcac tgggcctagc ccggggtggg aggcggtggg actccccgcg     60

gggcccgacc ccctggactc cactgatctg aacggggcgc acttcgaccc ggaactttac    120

ctagacaagc tgcctagaga gtgccctctg gcccagctga tagacagtga gacggacatg    180

gtgccgcaga tccgggctct agacagcgac atgcaaaccc tggtctatga gaactatgat    240

aagttcatcc cagccacaga aattgacaaa cagtacctcc cagtgccaag tgtataa       297


<210>  1698
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  1698

Met Ala Ala Ala Ala Val Thr Gly Pro Ser Pro Gly Trp Glu Ala Val 
1               5                   10                  15      


Gly Leu Pro Ala Gly Pro Asp Pro Leu Asp Ser Thr Asp Leu Asn Gly 
            20                  25                  30          


Ala His Phe Asp Pro Glu Leu Tyr Leu Asp Lys Leu Pro Arg Glu Cys 
        35                  40                  45              


Pro Leu Ala Gln Leu Ile Asp Ser Glu Thr Asp Met Val Pro Gln Ile 
    50                  55                  60                  


Arg Ala Leu Asp Ser Asp Met Gln Thr Leu Val Tyr Glu Asn Tyr Asp 
65                  70                  75                  80  


Lys Phe Ile Pro Ala Thr Glu Ile Asp Lys Gln Tyr Leu Pro Val Pro 
                85                  90                  95      


Ser Val 
        


<210>  1699
<211>  1477
<212>  DNA
<213>  Homosapiens

<400>  1699
cgctggcggc ttccgcagcc ttcaagtggg tcctccgccc ccggccctcc cctctcaggc     60

ggagccaaac tgcggccccg cctttacagt ctcggaaagg tccccagact ggaggctctg    120

aggaaggggt gtggggagtc gggggcggag acttggggcg gggggcgggc aataaactcc    180

caggccccgc ccacgccccg ccggggccct aatcctggac ccgggatccc gtgcgcctgg    240

agacagggtc cagatctgcc tccagcccct cgaaaccagg actccagcac ctctggtccc    300

gccctcaccc ggacccctgg ccctcacgtc tcctccaggg atggcgctgg cggctttgat    360

gatcgccctc ggcagcctcg gcctccacac ctggcaggcc caggctgttc ccatcctgcc    420

cctgggcctg gctccagaca cctttgacga tacctatgtg ggttgtgcag aggagatgga    480

ggagaaggca gcccccctgc taaaggagga aatggcccac catgccctgc tgcgggaatc    540

ctgggaggca gcccaggaga cctgggagga caagcgtcga gggcttacct tgccccctgg    600

cttcaaagcc cagaatggaa tagccattat ggtctacacc aactcatcga acaccttgta    660

ctgggagttg aatcaggccg tgcggacggg cggaggctcc cgggagctct acatgaggca    720

ctttcccttc aaggccctgc atttctacct gatccgggcc ctgcagctgc tgcgaggcag    780

tgggggctgc agcaggggac ctggggaggt ggtgttccga ggtgtgggca gccttcgctt    840

tgaacccaag aggctgggag actctgtccg cttgggccag tttgcctcca gctccctgga    900

taaggcagtg gcccacagat ttggtaatgc caccctcttc tctctaacaa cttgctttgg    960

ggcccctata caggccttct ctgtctttcc caaggagcgc gaggtgctga ttccccccca   1020

tgaagtcttt ttggttacca gattctctca ggatggagcc cagagcttgg tgactctctg   1080

gagctataat cagacctgta gccattttaa ctgcgcctat ctgggtgggg agaagaggcg   1140

gggctgtgtg tctgcgccag gagccctggg aacgggtgac cttcatatga cgaagaggca   1200

cctccagcag ccttgagaag caagaacatg gttccggacc cagccctagc agccttctcc   1260

ccaaccagga tgttggcctg gggaggccac agcagggctg agggaactct gctatgtgat   1320

ggggacttcc tgggacaagc aaggaaagta ctgaggcagc cacttgattg aacggtgttg   1380

caatgtggag acatggagtt ttattgaggt agctacgtga ttaaatggta ttgcagtgtg   1440

gagacatgga aaaaaaaaaa aaaaaaaaaa aaaaaaa                            1477


<210>  1700
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  1700

Met Ala Leu Ala Ala Leu Met Ile Ala Leu Gly Ser Leu Gly Leu His 
1               5                   10                  15      


Thr Trp Gln Ala Gln Ala Val Pro Ile Leu Pro Leu Gly Leu Ala Pro 
            20                  25                  30          


Asp Thr Phe Asp Asp Thr Tyr Val Gly Cys Ala Glu Glu Met Glu Glu 
        35                  40                  45              


Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala His His Ala Leu Leu 
    50                  55                  60                  


Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala Ile 
                85                  90                  95      


Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn Gln 
            100                 105                 110         


Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu Tyr Met Arg His Phe 
        115                 120                 125             


Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg Ala Leu Gln Leu Leu 
    130                 135                 140                 


Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly Glu Val Val Phe Arg 
145                 150                 155                 160 


Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg Leu Gly Asp Ser Val 
                165                 170                 175     


Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp Lys Ala Val Ala His 
            180                 185                 190         


Arg Phe Gly Asn Ala Thr Leu Phe Ser Leu Thr Thr Cys Phe Gly Ala 
        195                 200                 205             


Pro Ile Gln Ala Phe Ser Val Phe Pro Lys Glu Arg Glu Val Leu Ile 
    210                 215                 220                 


Pro Pro His Glu Val Phe Leu Val Thr Arg Phe Ser Gln Asp Gly Ala 
225                 230                 235                 240 


Gln Ser Leu Val Thr Leu Trp Ser Tyr Asn Gln Thr Cys Ser His Phe 
                245                 250                 255     


Asn Cys Ala Tyr Leu Gly Gly Glu Lys Arg Arg Gly Cys Val Ser Ala 
            260                 265                 270         


Pro Gly Ala Leu Gly Thr Gly Asp Leu His Met Thr Lys Arg His Leu 
        275                 280                 285             


Gln Gln Pro 
    290     


<210>  1701
<211>  1334
<212>  DNA
<213>  Homosapiens

<400>  1701
ggccatggtg gagatcagca gcagcttccc cacccaggac aaggcctaga tgaggaaact     60

gagacccaaa aagagacagc aactggccca gggtcaccag catgcagatg cctgctatga    120

tgtctctgct tcttgtgtct gtgggcctca tggaagcact tcaggcccag agccacccca    180

tcacacgacg agacctcttc tctcaagaga ttcagctgga catggccctg gcctcctttg    240

atgaccagta cgctggctgt gctgctgcca tgacagctgc tctcccggat ctcaaccaca    300

cggagttcca ggccaaccag gtgtatgcag acagctggac actggcaagc agccaatggc    360

aggagcgtca ggccaggtgg ccagagtgga gtctcagccc cacccgtcca tccccgccac    420

ccctgggctt ccgcgatgag catggggtgg ccctcctggc ctacacagcc aacagccccc    480

tgcacaagga gttcaatgca gccgtgcgtg aggcgggccg ctcccgggcc cactacctcc    540

accacttctc cttcaagaca ctccatttcc tgctgactga ggccctgcag ctcctgggca    600

gcggccagcg tccaccccgg tgccaccagg tgttccgagg tgtgcacggc ctgcgcttcc    660

ggccagcagg gccccgggcc accgtgaggc tggggggctt tgcttctgcc tccctgaagc    720

atgttgcagc ccagcagttt ggtgaggaca ccttcttcgg catctggacc tgccttgggg    780

cccctatcaa gggctactcc ttcttccctg gagaggaaga ggtgctgatc cccccctttg    840

agaccttcca agtgatcaat gccagcagac cggcccaggg ccccgcccgc atctacctcc    900

gagccctggg caagcacagc acctacaact gcgagtacat caaagacaag aagtgcaagt    960

ctgggccttg ccatctggat aattcagcca tgggtcagag ccccctctct gcagtctggt   1020

ctttgctgct gctgctctgg ttcctcgtgg tgagggcctt tccagatggt ccaggcctcc   1080

tttgatgcat gagacacggg acagcctcgc ctgctgcctc tgcccatcct gaggatgttg   1140

gccatgtgtg cttcagtgta accaagattc ctgtcaatcc catctgcagg gaactctggg   1200

accttctctg gtagctgcca gaccggctgg tggagaaaca ggagacaatc tggggactga   1260

accttaccca gggctgtagg agtgagactc tgaataaagg gttgggccgg caaaaaaaaa   1320

aaaaaaaaaa aaaa                                                     1334


<210>  1702
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1702

Met Gln Met Pro Ala Met Met Ser Leu Leu Leu Val Ser Val Gly Leu 
1               5                   10                  15      


Met Glu Ala Leu Gln Ala Gln Ser His Pro Ile Thr Arg Arg Asp Leu 
            20                  25                  30          


Phe Ser Gln Glu Ile Gln Leu Asp Met Ala Leu Ala Ser Phe Asp Asp 
        35                  40                  45              


Gln Tyr Ala Gly Cys Ala Ala Ala Met Thr Ala Ala Leu Pro Asp Leu 
    50                  55                  60                  


Asn His Thr Glu Phe Gln Ala Asn Gln Val Tyr Ala Asp Ser Trp Thr 
65                  70                  75                  80  


Leu Ala Ser Ser Gln Trp Gln Glu Arg Gln Ala Arg Trp Pro Glu Trp 
                85                  90                  95      


Ser Leu Ser Pro Thr Arg Pro Ser Pro Pro Pro Leu Gly Phe Arg Asp 
            100                 105                 110         


Glu His Gly Val Ala Leu Leu Ala Tyr Thr Ala Asn Ser Pro Leu His 
        115                 120                 125             


Lys Glu Phe Asn Ala Ala Val Arg Glu Ala Gly Arg Ser Arg Ala His 
    130                 135                 140                 


Tyr Leu His His Phe Ser Phe Lys Thr Leu His Phe Leu Leu Thr Glu 
145                 150                 155                 160 


Ala Leu Gln Leu Leu Gly Ser Gly Gln Arg Pro Pro Arg Cys His Gln 
                165                 170                 175     


Val Phe Arg Gly Val His Gly Leu Arg Phe Arg Pro Ala Gly Pro Arg 
            180                 185                 190         


Ala Thr Val Arg Leu Gly Gly Phe Ala Ser Ala Ser Leu Lys His Val 
        195                 200                 205             


Ala Ala Gln Gln Phe Gly Glu Asp Thr Phe Phe Gly Ile Trp Thr Cys 
    210                 215                 220                 


Leu Gly Ala Pro Ile Lys Gly Tyr Ser Phe Phe Pro Gly Glu Glu Glu 
225                 230                 235                 240 


Val Leu Ile Pro Pro Phe Glu Thr Phe Gln Val Ile Asn Ala Ser Arg 
                245                 250                 255     


Pro Ala Gln Gly Pro Ala Arg Ile Tyr Leu Arg Ala Leu Gly Lys His 
            260                 265                 270         


Ser Thr Tyr Asn Cys Glu Tyr Ile Lys Asp Lys Lys Cys Lys Ser Gly 
        275                 280                 285             


Pro Cys His Leu Asp Asn Ser Ala Met Gly Gln Ser Pro Leu Ser Ala 
    290                 295                 300                 


Val Trp Ser Leu Leu Leu Leu Leu Trp Phe Leu Val Val Arg Ala Phe 
305                 310                 315                 320 


Pro Asp Gly Pro Gly Leu Leu 
                325         


<210>  1703
<211>  1962
<212>  DNA
<213>  Homosapiens

<400>  1703
taattttgcc ctaggtctgg ccaggaggcc tcacatccag agacctgccc ccgctcttgc     60

agtgccaggg ccatggggct ccggagccac cacctcagcc tgggccttct gcttctgttt    120

ctactccctg cagagtgcct gggagctgag ggccggctgg ctctcaagct gttccgtgac    180

ctctttgcca actacacaag tgccctgaga cctgtggcag acacagacca gactctgaat    240

gtgaccctgg aggtgacact gtcccagatc atcgacatgg atgaacggaa ccaggtgctg    300

accctgtatc tgtggatacg gcaggagtgg acagatgcct acctacgatg ggaccccaat    360

gcctatggtg gcctggatgc catccgcatc cccagcagtc ttgtgtggcg gccagacatc    420

gtactctata acaaagccga cgcgcagcct ccaggttccg ccagcaccaa cgtggtcctg    480

cgccacgatg gcgccgtgcg ctgggacgcg ccggccatca cgcgcagctc gtgccgcgtg    540

gatgtagcag ccttcccgtt cgacgcccag cactgcggcc tgacgttcgg ctcctggact    600

cacggcgggc accaactgga tgtgcggccg cgcggcgctg cagccagcct ggcggacttc    660

gtggagaacg tggagtggcg cgtgctgggc atgccggcgc ggcggcgcgt gctcacctac    720

ggctgctgct ccgagcccta ccccgacgtc accttcacgc tgctgttgcg ccgccgcgcc    780

gccgcctacg tgtgcaacct gctgctgccc tgcgtgctca tctcgctgct tgcgccgctc    840

gccttccacc tgcctgccga ctcaggcgag aaggtgtcgc tgggcgtcac cgtgctgctg    900

gcgctcaccg tcttccagtt gctgctggcc gagagcatgc caccggccga gagcgtgccg    960

ctcatcggga agtactacat ggccactatg accatggtca cattctcaac agcactcacc   1020

atccttatca tgaacctgca ttactgtggt cccagtgtcc gcccagtgcc agcctgggct   1080

agggccctcc tgctgggaca cctggcacgg ggcctgtgcg tgcgggaaag aggggagccc   1140

tgtgggcagt ccaggccacc tgagttatct cctagccccc agtcgcctga aggaggggct   1200

ggccccccag cgggcccttg ccacgagcca cgatgtctgt gccgccagga agccctactg   1260

caccacgtag ccaccattgc caataccttc cgcagccacc gagctgccca gcgctgccat   1320

gaggactgga agcgcctggc ccgtgtgatg gaccgcttct tcctggccat cttcttctcc   1380

atggccctgg tcatgagcct cctggtgctg gtgcaggccc tgtgagggct gggactaagt   1440

cacagggatc tgctgcagcc acagctcctc cagaaaggga cagccacggc caagtggttg   1500

ctggtctttg ggccagccag tctctcccca ctgctcctaa gatcctgaga cacttgactt   1560

cacaatccac aagggagcac tcattgtcta cacaccctaa ctaaaggaag tccagagcct   1620

gccactcccc taattccaaa aaaaagagga actctacaaa ggccaagatc acagagtaca   1680

gtcttggagg gacagaattg tttgtgctgg gtattggagc tctcagtggg gagcacatgg   1740

gttataatga gaaactgaac tgtactgctg catttcctgt cttccttcct aggtggctgc   1800

tttgcagggc tttggctgtt acctttccct gctgaggggc tcagggaaaa gggtcgggga   1860

ttctcagtcg agtttccaga gcaggaggcc ctacagacat ttcgccccaa atccctgact   1920

caataaagta agcgtgtacc tagcaaaaaa aaaaaaaaaa aa                      1962


<210>  1704
<211>  450
<212>  PRT
<213>  Homosapiens

<400>  1704

Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys 
            20                  25                  30          


Leu Phe Arg Asp Leu Phe Ala Asn Tyr Thr Ser Ala Leu Arg Pro Val 
        35                  40                  45              


Ala Asp Thr Asp Gln Thr Leu Asn Val Thr Leu Glu Val Thr Leu Ser 
    50                  55                  60                  


Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu Thr Leu Tyr Leu 
65                  70                  75                  80  


Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu Arg Trp Asp Pro Asn 
                85                  90                  95      


Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser Ser Leu Val Trp 
            100                 105                 110         


Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala Gln Pro Pro Gly 
        115                 120                 125             


Ser Ala Ser Thr Asn Val Val Leu Arg His Asp Gly Ala Val Arg Trp 
    130                 135                 140                 


Asp Ala Pro Ala Ile Thr Arg Ser Ser Cys Arg Val Asp Val Ala Ala 
145                 150                 155                 160 


Phe Pro Phe Asp Ala Gln His Cys Gly Leu Thr Phe Gly Ser Trp Thr 
                165                 170                 175     


His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly Ala Ala Ala Ser 
            180                 185                 190         


Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val Leu Gly Met Pro 
        195                 200                 205             


Ala Arg Arg Arg Val Leu Thr Tyr Gly Cys Cys Ser Glu Pro Tyr Pro 
    210                 215                 220                 


Asp Val Thr Phe Thr Leu Leu Leu Arg Arg Arg Ala Ala Ala Tyr Val 
225                 230                 235                 240 


Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu Leu Ala Pro Leu 
                245                 250                 255     


Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val Ser Leu Gly Val 
            260                 265                 270         


Thr Val Leu Leu Ala Leu Thr Val Phe Gln Leu Leu Leu Ala Glu Ser 
        275                 280                 285             


Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys Tyr Tyr Met Ala 
    290                 295                 300                 


Thr Met Thr Met Val Thr Phe Ser Thr Ala Leu Thr Ile Leu Ile Met 
305                 310                 315                 320 


Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val Pro Ala Trp Ala 
                325                 330                 335     


Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu Cys Val Arg Glu 
            340                 345                 350         


Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu Leu Ser Pro Ser 
        355                 360                 365             


Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala Gly Pro Cys His 
    370                 375                 380                 


Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu His His Val Ala 
385                 390                 395                 400 


Thr Ile Ala Asn Thr Phe Arg Ser His Arg Ala Ala Gln Arg Cys His 
                405                 410                 415     


Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg Phe Phe Leu Ala 
            420                 425                 430         


Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu Val Leu Val Gln 
        435                 440                 445             


Ala Leu 
    450 


<210>  1705
<211>  3778
<212>  DNA
<213>  Homosapiens

<400>  1705
gcccaatgaa taacagggtc gacccagagt ggcggccgcg tccaccaatt cgcggacggc     60

gagggcggag cgtccgcaac gagcctctga cgccgggcgg cgtgtgacgc agtcgggccc    120

tctgcgcgct gcgcccgaag cggcggtcgg tggcaggggt ggtagcggcg gcggcgacgg    180

tttcgtgggg gccgcgcgct gctctgtgag cggcgggtgg cagcagggga ctcctgacac    240

ttccccttcc ccaccgaacc gcgctttctg aaacaaagac tcattttgaa gatgtttaac    300

aaatcatttg gaacaccctt tgggggtggc acaggtggct ttggcacaac ttcaacattt    360

ggacagaata ctggctttgg cactactagt ggaggggcat ttggaacatc tgcatttggt    420

tctagcaaca atactggagg cctctttgga aattcacaga ctaaaccagg aggattgttt    480

ggaaccagtt catttagcca gccagctacc tccacaagca ctggctttgg gtttggtacg    540

tcaacaggaa cagcaaatac cttgtttgga actgcaagca cagggaccag tctcttctca    600

tcccaaaaca atgcctttgc acaaaataaa ccaactggct ttggcaattt tggaaccagt    660

actagcagtg gaggactctt tggaaccaca aataccacct ctaatccttt tggcagcaca    720

tctggctccc tctttgggcc aagtagtttt acagctgctc ctactgggac tactattaaa    780

tttaaccctc caactggtac agatactatg gtcaaagctg gagttagcac taacataagt    840

accaagcacc agtgtattac tgctatgaaa gaatatgaaa gcaagtcact agaggaactt    900

cgtttagagg attatcaggc taacaggaag ggcccacaga accaggtggg agcaggtacc    960

acaactggct tgtttgggtc ttctccagcc acttccagcg caacaggact cttcagctcc   1020

tccaccacta attcaggctt tgcatatggt cagaacaaaa ctgcctttgg aactagtaca   1080

actggatttg gaacaaatcc aggtggtctc tttggccaac agaatcagca gactaccagc   1140

ctcttcagca aaccatttgg ccaggctaca accacccaga acactggctt ttcctttggt   1200

aataccagca ccataggaca gccaagcacc aacaccatgg gattatttgg agtaacccaa   1260

gcctcacagc ctggaggtct ttttgggaca gctacaaaca ccagcactgg gacagcattt   1320

ggaacaggaa caggtctctt tgggcagacc aatactggat ttggtgctgt tggttcgacc   1380

ctgtttggca ataacaagct tactacattt ggaagcagca caaccagtgc accttcattt   1440

ggtacaacca gtggcgggct ctttggtttt ggcacaaata ccagtgggaa tagtattttt   1500

ggaagtaaac cagcacctgg gactcttgga actgggcttg gtgcaggatt tggaacagct   1560

cttggtgctg gacaggcatc tttgtttggg aacaaccaac ctaagattgg agggcctctt   1620

ggtacaggag cctttggggc ccctggattt aatactacga cagccacttt gggctttgga   1680

gccccccagg ccccagtagc tttgacagat ccaaatgctt ctgctgccca gcaggctgtt   1740

ctccagcagc acatcaatag tctaacatac tcaccttttg gagactctcc tctcttccgg   1800

aatccgatgt cagaccctaa gaagaaggaa gagagattga aaccaacaaa tccagcagcc   1860

cagaaggctc ttactacacc tactcattat aaactgacac cccgccctgc cactagagtc   1920

cggccaaagg ctttacaaac aacaggcaca gccaagtcac atctctttga tgggctggat   1980

gacgatgaac catccctagc caatggagca ttcatgccca agaagagcat taagaagttg   2040

gttttgaaga accttaataa tagcaatctc ttttctcctg ttaatcgtga ttcagaaaat   2100

ctagcttcac catctgaata tccagaaaat ggagagagat ttagtttcct aagcaaacct   2160

gttgatgaga atcaccagca ggatggagat gaagattccc ttgtttcaca tttttatact   2220

aaccctattg ccaaacctat tcctcaaacc ccagaaagtg ctggaaataa acacagcaac   2280

agcaacagtg tggatgatac cattgttgca ttaaacatgc gtgctgcttt gcgaaatggg   2340

ctggaaggaa gcagtgaaga aacgtctttt catgatgagt cacttcagga tgaccgagaa   2400

gaaatagaaa ataattctta ccatatgcac ccagcaggta ttattctcac taaggttggt   2460

tactatacta ttccatctat ggatgacctt gctaaaatta ccaatgaaaa aggagagtgc   2520

attgtctctg atttcactat tggtcggaaa ggttatggtt caatctattt tgaaggagat   2580

gtgaatttga caaatctaaa tttggatgat attgtgcata tccggaggaa agaagtagtt   2640

gtctacttag atgataacca aaaaccacct gtgggtgaag ggctaaatag gaaggctgaa   2700

gttacattgg atggagtttg gccaacagat aaaacatctc gttgtttaat aaagagccca   2760

gatcgccttg ctgatatcaa ctatgaagga agattggaag cagtttcaag gaaacaggga   2820

gctcaattca aagaataccg gcctgaaact ggttcttggg tgtttaaggt ctcccatttt   2880

tctaagtatg gccttcagga ttctgatgaa gaggaggagg agcatccgtc taaaactagt   2940

acaaagaagt tgaagactgc tcctttgcct cctgcaagcc agactacgcc cttgcagatg   3000

gctcttaatg gcaaacctgc acctccacct caggtagaga aaaaaggaca gtgaatttga   3060

atggaatccg tgataccgaa gttgaaagca agtcattcag ctaatacaaa gctgttttat   3120

gacccttgga actttgaaga gtacaaacat tggcaatcac gttgaaacaa gtgcaaggga   3180

gggcgtgagg tcttgcaggc atctgtcttt ttactggaga gatttaaaga attctcttgc   3240

tgtttggatt attcctctac agattgtcat ttttaaaccc tttgttctct ctcatttgga   3300

cttgctgaat tctctgctca gtgattaact taagatttgc tcatgtgggt tcatgcacag   3360

taaattctgc ctttattgac tacctgatgt gcagtttaat ctttttcttt acctccatgg   3420

ttttttaaaa gttaaattag ctttctgaaa gggtttttaa tctccatttt tttaaagttg   3480

tttgcttata cttcgggtaa ccttgatatt tgtattttaa tagtacataa tctttatgaa   3540

aaatagtttg ggaatgtaaa tgaattatta tttggcttgg ggagattagg gcctacattg   3600

tttatcgcaa ttacttgtat cattgatacg ggatttcttt gtaaagcatc ctctacctct   3660

cagctgctga aagctagacc tttggtattt tccatgctat aattcttatg gctgctgaaa   3720

tgtgtggttt ttatgattta ttaaataatc tcttaggagg catttctgaa aaaaaaaa     3778


<210>  1706
<211>  920
<212>  PRT
<213>  Homosapiens

<400>  1706

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val 
    770                 775                 780                 


Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser 
865                 870                 875                 880 


Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Val Glu Lys Lys Gly Gln 
        915                 920 


<210>  1707
<211>  3829
<212>  DNA
<213>  Homosapiens

<400>  1707
gcccaatgaa taacagggtc gacccagagt ggcggccgcg tccaccaatt cgcggacggc     60

gagggcggag cgtccgcaac gagcctctga cgccgggcgg cgtgtgacgc agtcgggccc    120

tctgcgcgct gcgcccgaag cggcggtcgg tggcaggggt ggtagcggcg gcggcgacgg    180

tttcgtgggg gccgcgcgct gctctgtgag cggcgggtgg cagcagggga ctcctgacac    240

ttccccttcc ccaccgaacc gcgctttctg aaacaaagac tcattttgaa gatgtttaac    300

aaatcatttg gaacaccctt tgggggtggc acaggtggct ttggcacaac ttcaacattt    360

ggacagaata ctggctttgg cactactagt ggaggggcat ttggaacatc tgcatttggt    420

tctagcaaca atactggagg cctctttgga aattcacaga ctaaaccagg aggattgttt    480

ggaaccagtt catttagcca gccagctacc tccacaagca ctggctttgg gtttggtacg    540

tcaacaggaa cagcaaatac cttgtttgga actgcaagca cagggaccag tctcttctca    600

tcccaaaaca atgcctttgc acaaaataaa ccaactggct ttggcaattt tggaaccagt    660

actagcagtg gaggactctt tggaaccaca aataccacct ctaatccttt tggcagcaca    720

tctggctccc tctttgggcc aagtagtttt acagctgctc ctactgggac tactattaaa    780

tttaaccctc caactggtac agatactatg gtcaaagctg gagttagcac taacataagt    840

accaagcacc agtgtattac tgctatgaaa gaatatgaaa gcaagtcact agaggaactt    900

cgtttagagg attatcaggc taacaggaag ggcccacaga accaggtggg agcaggtacc    960

acaactggct tgtttgggtc ttctccagcc acttccagcg caacaggact cttcagctcc   1020

tccaccacta attcaggctt tgcatatggt cagaacaaaa ctgcctttgg aactagtaca   1080

actggatttg gaacaaatcc aggtggtctc tttggccaac agaatcagca gactaccagc   1140

ctcttcagca aaccatttgg ccaggctaca accacccaga acactggctt ttcctttggt   1200

aataccagca ccataggaca gccaagcacc aacaccatgg gattatttgg agtaacccaa   1260

gcctcacagc ctggaggtct ttttgggaca gctacaaaca ccagcactgg gacagcattt   1320

ggaacaggaa caggtctctt tgggcagacc aatactggat ttggtgctgt tggttcgacc   1380

ctgtttggca ataacaagct tactacattt ggaagcagca caaccagtgc accttcattt   1440

ggtacaacca gtggcgggct ctttggtaac aaaccaaccc tgactttagg aaccaataca   1500

aacacttcta attttggttt tggcacaaat accagtggga atagtatttt tggaagtaaa   1560

ccagcacctg ggactcttgg aactgggctt ggtgcaggat ttggaacagc tcttggtgct   1620

ggacaggcat ctttgtttgg gaacaaccaa cctaagattg gagggcctct tggtacagga   1680

gcctttgggg cccctggatt taatactacg acagccactt tgggctttgg agccccccag   1740

gccccagtag ctttgacaga tccaaatgct tctgctgccc agcaggctgt tctccagcag   1800

cacatcaata gtctaacata ctcacctttt ggagactctc ctctcttccg gaatccgatg   1860

tcagacccta agaagaagga agagagattg aaaccaacaa atccagcagc ccagaaggct   1920

cttactacac ctactcatta taaactgaca ccccgccctg ccactagagt ccggccaaag   1980

gctttacaaa caacaggcac agccaagtca catctctttg atgggctgga tgacgatgaa   2040

ccatccctag ccaatggagc attcatgccc aagaagagca ttaagaagtt ggttttgaag   2100

aaccttaata atagcaatct cttttctcct gttaatcgtg attcagaaaa tctagcttca   2160

ccatctgaat atccagaaaa tggagagaga tttagtttcc taagcaaacc tgttgatgag   2220

aatcaccagc aggatggaga tgaagattcc cttgtttcac atttttatac taaccctatt   2280

gccaaaccta ttcctcaaac cccagaaagt gctggaaata aacacagcaa cagcaacagt   2340

gtggatgata ccattgttgc attaaacatg cgtgctgctt tgcgaaatgg gctggaagga   2400

agcagtgaag aaacgtcttt tcatgatgag tcacttcagg atgaccgaga agaaatagaa   2460

aataattctt accatatgca cccagcaggt attattctca ctaaggttgg ttactatact   2520

attccatcta tggatgacct tgctaaaatt accaatgaaa aaggagagtg cattgtctct   2580

gatttcacta ttggtcggaa aggttatggt tcaatctatt ttgaaggaga tgtgaatttg   2640

acaaatctaa atttggatga tattgtgcat atccggagga aagaagtagt tgtctactta   2700

gatgataacc aaaaaccacc tgtgggtgaa gggctaaata ggaaggctga agttacattg   2760

gatggagttt ggccaacaga taaaacatct cgttgtttaa taaagagccc agatcgcctt   2820

gctgatatca actatgaagg aagattggaa gcagtttcaa ggaaacaggg agctcaattc   2880

aaagaatacc ggcctgaaac tggttcttgg gtgtttaagg tctcccattt ttctaagtat   2940

ggccttcagg attctgatga agaggaggag gagcatccgt ctaaaactag tacaaagaag   3000

ttgaagactg ctcctttgcc tcctgcaagc cagactacgc ccttgcagat ggctcttaat   3060

ggcaaacctg cacctccacc tcaggtagag aaaaaaggac agtgaatttg aatggaatcc   3120

gtgataccga agttgaaagc aagtcattca gctaatacaa agctgtttta tgacccttgg   3180

aactttgaag agtacaaaca ttggcaatca cgttgaaaca agtgcaaggg agggcgtgag   3240

gtcttgcagg catctgtctt tttactggag agatttaaag aattctcttg ctgtttggat   3300

tattcctcta cagattgtca tttttaaacc ctttgttctc tctcatttgg acttgctgaa   3360

ttctctgctc agtgattaac ttaagatttg ctcatgtggg ttcatgcaca gtaaattctg   3420

cctttattga ctacctgatg tgcagtttaa tctttttctt tacctccatg gttttttaaa   3480

agttaaatta gctttctgaa agggttttta atctccattt ttttaaagtt gtttgcttat   3540

acttcgggta accttgatat ttgtatttta atagtacata atctttatga aaaatagttt   3600

gggaatgtaa atgaattatt atttggcttg gggagattag ggcctacatt gtttatcgca   3660

attacttgta tcattgatac gggatttctt tgtaaagcat cctctacctc tcagctgctg   3720

aaagctagac ctttggtatt ttccatgcta taattcttat ggctgctgaa atgtgtggtt   3780

tttatgattt attaaataat ctcttaggag gcatttctga aaaaaaaaa               3829


<210>  1708
<211>  937
<212>  PRT
<213>  Homosapiens

<400>  1708

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly 
385                 390                 395                 400 


Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Thr Ser Gly 
                405                 410                 415     


Asn Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly 
            420                 425                 430         


Leu Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu 
        435                 440                 445             


Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala 
    450                 455                 460                 


Phe Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly 
465                 470                 475                 480 


Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala 
                485                 490                 495     


Gln Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro 
            500                 505                 510         


Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys 
        515                 520                 525             


Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu 
    530                 535                 540                 


Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val 
545                 550                 555                 560 


Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe 
                565                 570                 575     


Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met 
            580                 585                 590         


Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser 
        595                 600                 605             


Asn Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro 
    610                 615                 620                 


Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro 
625                 630                 635                 640 


Val Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser 
                645                 650                 655     


His Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu 
            660                 665                 670         


Ser Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile 
        675                 680                 685             


Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser 
    690                 695                 700                 


Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu 
705                 710                 715                 720 


Glu Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu 
                725                 730                 735     


Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys 
            740                 745                 750         


Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly 
        755                 760                 765             


Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr 
    770                 775                 780                 


Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val 
785                 790                 795                 800 


Val Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn 
                805                 810                 815     


Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr 
            820                 825                 830         


Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr 
        835                 840                 845             


Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys 
    850                 855                 860                 


Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe 
865                 870                 875                 880 


Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro 
                885                 890                 895     


Ser Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala 
            900                 905                 910         


Ser Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro 
        915                 920                 925             


Pro Pro Gln Val Glu Lys Lys Gly Gln 
    930                 935         


<210>  1709
<211>  6850
<212>  DNA
<213>  Homosapiens

<400>  1709
gcccaatgaa taacagggtc gacccagagt ggcggccgcg tccaccaatt cgcggacggc     60

gagggcggag cgtccgcaac gagcctctga cgccgggcgg cgtgtgacgc agtcgggccc    120

tctgcgcgct gcgcccgaag cggcggtcgg tggcaggggt ggtagcggcg gcggcgacgg    180

tttcgtgggg gccgcgcgct gctctgtgag cggcgggtgg cagcagggga ctcctgacac    240

ttccccttcc ccaccgaacc gcgctttctg aaacaaagac tcattttgaa gatgtttaac    300

aaatcatttg gaacaccctt tgggggtggc acaggtggct ttggcacaac ttcaacattt    360

ggacagaata ctggctttgg cactactagt ggaggggcat ttggaacatc tgcatttggt    420

tctagcaaca atactggagg cctctttgga aattcacaga ctaaaccagg aggattgttt    480

ggaaccagtt catttagcca gccagctacc tccacaagca ctggctttgg gtttggtacg    540

tcaacaggaa cagcaaatac cttgtttgga actgcaagca cagggaccag tctcttctca    600

tcccaaaaca atgcctttgc acaaaataaa ccaactggct ttggcaattt tggaaccagt    660

actagcagtg gaggactctt tggaaccaca aataccacct ctaatccttt tggcagcaca    720

tctggctccc tctttgggcc aagtagtttt acagctgctc ctactgggac tactattaaa    780

tttaaccctc caactggtac agatactatg gtcaaagctg gagttagcac taacataagt    840

accaagcacc agtgtattac tgctatgaaa gaatatgaaa gcaagtcact agaggaactt    900

cgtttagagg attatcaggc taacaggaag ggcccacaga accaggtggg agcaggtacc    960

acaactggct tgtttgggtc ttctccagcc acttccagcg caacaggact cttcagctcc   1020

tccaccacta attcaggctt tgcatatggt cagaacaaaa ctgcctttgg aactagtaca   1080

actggatttg gaacaaatcc aggtggtctc tttggccaac agaatcagca gactaccagc   1140

ctcttcagca aaccatttgg ccaggctaca accacccaga acactggctt ttcctttggt   1200

aataccagca ccataggaca gccaagcacc aacaccatgg gattatttgg agtaacccaa   1260

gcctcacagc ctggaggtct ttttgggaca gctacaaaca ccagcactgg gacagcattt   1320

ggaacaggaa caggtctctt tgggcagacc aatactggat ttggtgctgt tggttcgacc   1380

ctgtttggca ataacaagct tactacattt ggaagcagca caaccagtgc accttcattt   1440

ggtacaacca gtggcgggct ctttggtttt ggcacaaata ccagtgggaa tagtattttt   1500

ggaagtaaac cagcacctgg gactcttgga actgggcttg gtgcaggatt tggaacagct   1560

cttggtgctg gacaggcatc tttgtttggg aacaaccaac ctaagattgg agggcctctt   1620

ggtacaggag cctttggggc ccctggattt aatactacga cagccacttt gggctttgga   1680

gccccccagg ccccagtagc tttgacagat ccaaatgctt ctgctgccca gcaggctgtt   1740

ctccagcagc acatcaatag tctaacatac tcaccttttg gagactctcc tctcttccgg   1800

aatccgatgt cagaccctaa gaagaaggaa gagagattga aaccaacaaa tccagcagcc   1860

cagaaggctc ttactacacc tactcattat aaactgacac cccgccctgc cactagagtc   1920

cggccaaagg ctttacaaac aacaggcaca gccaagtcac atctctttga tgggctggat   1980

gacgatgaac catccctagc caatggagca ttcatgccca agaagagcat taagaagttg   2040

gttttgaaga accttaataa tagcaatctc ttttctcctg ttaatcgtga ttcagaaaat   2100

ctagcttcac catctgaata tccagaaaat ggagagagat ttagtttcct aagcaaacct   2160

gttgatgaga atcaccagca ggatggagat gaagattccc ttgtttcaca tttttatact   2220

aaccctattg ccaaacctat tcctcaaacc ccagaaagtg ctggaaataa acacagcaac   2280

agcaacagtg tggatgatac cattgttgca ttaaacatgc gtgctgcttt gcgaaatggg   2340

ctggaaggaa gcagtgaaga aacgtctttt catgatgagt cacttcagga tgaccgagaa   2400

gaaatagaaa ataattctta ccatatgcac ccagcaggta ttattctcac taaggttggt   2460

tactatacta ttccatctat ggatgacctt gctaaaatta ccaatgaaaa aggagagtgc   2520

attgtctctg atttcactat tggtcggaaa ggttatggtt caatctattt tgaaggagat   2580

gtgaatttga caaatctaaa tttggatgat attgtgcata tccggaggaa agaagtagtt   2640

gtctacttag atgataacca aaaaccacct gtgggtgaag ggctaaatag gaaggctgaa   2700

gttacattgg atggagtttg gccaacagat aaaacatctc gttgtttaat aaagagccca   2760

gatcgccttg ctgatatcaa ctatgaagga agattggaag cagtttcaag gaaacaggga   2820

gctcaattca aagaataccg gcctgaaact ggttcttggg tgtttaaggt ctcccatttt   2880

tctaagtatg gccttcagga ttctgatgaa gaggaggagg agcatccgtc taaaactagt   2940

acaaagaagt tgaagactgc tcctttgcct cctgcaagcc agactacgcc cttgcagatg   3000

gctcttaatg gcaaacctgc acctccacct cagagccaga gcccagaggt ggagcagtta   3060

gggagggttg tggaactgga cagtgacatg gtagatatca cccaggagcc agttttggat   3120

accatgttag aagagagcat gcctgaggat caggaacctg tgtctgcctc aacacatatt   3180

gcatcttcac tgggaattaa tccacatgtc ttacagatca tgaaagcatc attgcttact   3240

gatgaagaag atgtagatat ggcactggat caacgcttca gtcgcctgcc ttccaaagca   3300

gatacttctc aagaaatctg ttctcccaga ctccccattt cagcatccca ctcgtcgaaa   3360

actcgttcac tagttggtgg gttactacaa tcaaaattta caagtggagc ttttctttca   3420

ccaagtgtct ctgtgcaaga atgtcgtact cccagagcag catctttaat gaatatccca   3480

tccacatcct cttggtctgt ccctccaccc ctgacttctg tgttcacaat gcccagccca   3540

gcccctgagg ttccgttgaa aacagtgggt acacgtaggc aactaggcct agtccctcgt   3600

gaaaagtctg tcacctatgg caagggaaaa ctcttgatgg acatggccct attcatggga   3660

cgctcatttc gtgttggttg gggccccaac tggactcttg ctaatagtgg agaacagctg   3720

aatggctctc atgaactaga aaatcatcag attgccgatt ccatggagtt tggattcctg   3780

cccaatccag tagctgttaa acccctaact gagtccccat tcaaagttca cttagaaaaa   3840

ctcagtttga gacaaagaaa gccagatgaa gacatgaaat tatatcagac acctctggag   3900

ctcaaattaa aacacagcac tgtccatgtg gatgaactgt gtcctctcat tgtccccaat   3960

ctgggagttg ctgtcattca tgactatgca gattgggtta aagaagcatc aggagactta   4020

ccagaagcac aaattgtgaa gcactggagc ctgacatgga cactatgtga agccctatgg   4080

ggccacctga aggagcttga cagccagcta aatgaacccc gtgaatacat tcaaattctg   4140

gagcgaagaa gagctttctc ccgctggcta tcctgtactg ccacacctca gattgaagag   4200

gaagtctcct taacccaaaa aaacagccct gtggaggctg tattcagcta cctcacaggc   4260

aaaaggatca gtgaggcctg ctctctggcc cagcagtcag gggatcatcg tcttgctctt   4320

cttttatctc agtttgtggg tagccagtca gtccgggagc tgctcaccat gcagttggtg   4380

gactggcatc agctccaagc agactccttc atccaggatg agagactgcg catctttgct   4440

ctgttggctg gaaaaccggt gtggcagctc tcagaaaaga agcaaataaa cgtgtgctcc   4500

cagttggatt ggaaacgctc cctggctatc catctttggt atttgcttcc accaacagcc   4560

tccatttcta gggcgctcag catgtatgaa gaagcatttc agaatacctc tgacagtgac   4620

agatatgcct gctccccact tccttcgtat ctggagggtt ctggctgtgt gatagcggag   4680

gagcaaaact cacagacacc acttcgagat gtctgctttc accttctaaa actctacagt   4740

gacagacatt atgatctcaa ccagctgctg gagcctcgaa gcataacagc agatcctttg   4800

gactaccgcc taagctggca cttgtgggaa gtgctgaggg ctcttaacta cacccatctc   4860

tcagcgcagt gtgaaggtgt gctacaggcc agttacgctg gccagcttga aagtgagggg   4920

ctctgggagt gggccatctt tgtcctcctg cacattgaca actcaggcat acgtgagaag   4980

gctgttcgag agctgcttac ccggcactgc cagctgttgg agacccctga atcttgggct   5040

aaagagactt tccttaccca gaagctccgt gtacctgcca aatggatcca cgaggccaaa   5100

gctgtgcgag cacacatgga atctgacaag cacttagagg ccctttgctt atttaaggct   5160

gagcactgga accgctgcca caagctcatc atccgacact tagcttctga tgccatcatt   5220

aatgagaact atgactacct gaaggggttc ttggaagacc tggcacctcc agagcgcagc   5280

agcctaattc aggattggga aacatctggg cttgtttacc tggactatat tagagtcatt   5340

gaaatgctcc gccatataca gcaggtggat tgctcaggta atgacctgga gcagttacac   5400

atcaaagtga cttcactgtg cagtcggata gagcagattc agtgttacag tgctaaagat   5460

cgcctggctc agtcagacat ggccaaacgt gtagccaacc tgctgcgcgt ggtgctgagt   5520

ctgcatcatc ctcctgatag aacctccgac tcaacaccag accctcagcg agtccctttg   5580

cgcctcttgg ctccccacat tggccggctt cccatgcctg aggactatgc catggacgaa   5640

ctgcgcagcc ttacccagtc ctatctgcga gaactggctg ttgggagcct gtgagcccca   5700

ggcactttgc atcacagtca catgcccatt cacaccacac agaggttccc tgccttgttt   5760

ggattggcac tgtttgccat tctctgggtt ggctgtggca tctaccctcc ctccctgctg   5820

ccagaagcag catcctccac ttgttcaggg cttttcttaa tactgaacgt agcataaggg   5880

cttctggaac ccagaagagg agacagttta ccatcctcaa gatcattcag tgtttttcct   5940

ttaaaaaaat ggtcaataaa gctcctttgg cagaatcccc caaagaacca gggtattctt   6000

tttccatccc tagccattct ggatcttgtg accctccatg ccaaccagct tccctactcc   6060

taccctggcc cttttatact aggactcctt aggaggagtg agacaggtga taatggatcc   6120

ttaacagatg aactatccac agaaggaaga gggatccgtc tcttaagtaa ttggttagtt   6180

aacactgaat tttggaggca aaggagggtt ggcctgagtt aggaaacaaa atgggatctt   6240

tctgacacac ttagggcaga agtgaatgcc tgtcacggag ggattgatct tcagggctgt   6300

ttttgttcct gcctttagag ttccatgaac accatacctt tgctactact atgtgcagga   6360

acccttggtc acatgtgaca tgtctgtggg aagctcccag agtttggttt ggtccctggt   6420

tttcagtctt gctgagactc tgtctggatt tgcctgcaga gtttggataa aaaatggcag   6480

gttgggtaac cctccctgtt catcccatgt tagctccaaa gcatttccca ccctccatct   6540

accccttcca gaagcaaaaa caaaccatga ctgaggcagg catggagttg ggcgttaggg   6600

gcaggcagag ggcctttgct acactgctga cagctatagg gagccccagg taatggcatg   6660

agatagctgg tgttagggct atctcaggca atatggccac acctgggtct ttatgcatga   6720

agataatgta aaggttttta ttaaaaaata tatatatgta taaataaatg atctagatat   6780

tttcctcttt ttctgaagct actttcttaa aaaataaata aaatgtttat agcattcctg   6840

gtaaaaaaaa                                                          6850


<210>  1710
<211>  1800
<212>  PRT
<213>  Homosapiens

<400>  1710

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val 
    770                 775                 780                 


Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser 
865                 870                 875                 880 


Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu 
        915                 920                 925             


Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr 
    930                 935                 940                 


Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser 
945                 950                 955                 960 


Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile 
                965                 970                 975     


Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu 
            980                 985                 990         


Asp Gln Arg Phe Ser Arg Leu Pro  Ser Lys Ala Asp Thr  Ser Gln Glu 
        995                 1000                 1005             


Ile Cys  Ser Pro Arg Leu Pro  Ile Ser Ala Ser His  Ser Ser Lys 
    1010                 1015                 1020             


Thr Arg  Ser Leu Val Gly Gly  Leu Leu Gln Ser Lys  Phe Thr Ser 
    1025                 1030                 1035             


Gly Ala  Phe Leu Ser Pro Ser  Val Ser Val Gln Glu  Cys Arg Thr 
    1040                 1045                 1050             


Pro Arg  Ala Ala Ser Leu Met  Asn Ile Pro Ser Thr  Ser Ser Trp 
    1055                 1060                 1065             


Ser Val  Pro Pro Pro Leu Thr  Ser Val Phe Thr Met  Pro Ser Pro 
    1070                 1075                 1080             


Ala Pro  Glu Val Pro Leu Lys  Thr Val Gly Thr Arg  Arg Gln Leu 
    1085                 1090                 1095             


Gly Leu  Val Pro Arg Glu Lys  Ser Val Thr Tyr Gly  Lys Gly Lys 
    1100                 1105                 1110             


Leu Leu  Met Asp Met Ala Leu  Phe Met Gly Arg Ser  Phe Arg Val 
    1115                 1120                 1125             


Gly Trp  Gly Pro Asn Trp Thr  Leu Ala Asn Ser Gly  Glu Gln Leu 
    1130                 1135                 1140             


Asn Gly  Ser His Glu Leu Glu  Asn His Gln Ile Ala  Asp Ser Met 
    1145                 1150                 1155             


Glu Phe  Gly Phe Leu Pro Asn  Pro Val Ala Val Lys  Pro Leu Thr 
    1160                 1165                 1170             


Glu Ser  Pro Phe Lys Val His  Leu Glu Lys Leu Ser  Leu Arg Gln 
    1175                 1180                 1185             


Arg Lys  Pro Asp Glu Asp Met  Lys Leu Tyr Gln Thr  Pro Leu Glu 
    1190                 1195                 1200             


Leu Lys  Leu Lys His Ser Thr  Val His Val Asp Glu  Leu Cys Pro 
    1205                 1210                 1215             


Leu Ile  Val Pro Asn Leu Gly  Val Ala Val Ile His  Asp Tyr Ala 
    1220                 1225                 1230             


Asp Trp  Val Lys Glu Ala Ser  Gly Asp Leu Pro Glu  Ala Gln Ile 
    1235                 1240                 1245             


Val Lys  His Trp Ser Leu Thr  Trp Thr Leu Cys Glu  Ala Leu Trp 
    1250                 1255                 1260             


Gly His  Leu Lys Glu Leu Asp  Ser Gln Leu Asn Glu  Pro Arg Glu 
    1265                 1270                 1275             


Tyr Ile  Gln Ile Leu Glu Arg  Arg Arg Ala Phe Ser  Arg Trp Leu 
    1280                 1285                 1290             


Ser Cys  Thr Ala Thr Pro Gln  Ile Glu Glu Glu Val  Ser Leu Thr 
    1295                 1300                 1305             


Gln Lys  Asn Ser Pro Val Glu  Ala Val Phe Ser Tyr  Leu Thr Gly 
    1310                 1315                 1320             


Lys Arg  Ile Ser Glu Ala Cys  Ser Leu Ala Gln Gln  Ser Gly Asp 
    1325                 1330                 1335             


His Arg  Leu Ala Leu Leu Leu  Ser Gln Phe Val Gly  Ser Gln Ser 
    1340                 1345                 1350             


Val Arg  Glu Leu Leu Thr Met  Gln Leu Val Asp Trp  His Gln Leu 
    1355                 1360                 1365             


Gln Ala  Asp Ser Phe Ile Gln  Asp Glu Arg Leu Arg  Ile Phe Ala 
    1370                 1375                 1380             


Leu Leu  Ala Gly Lys Pro Val  Trp Gln Leu Ser Glu  Lys Lys Gln 
    1385                 1390                 1395             


Ile Asn  Val Cys Ser Gln Leu  Asp Trp Lys Arg Ser  Leu Ala Ile 
    1400                 1405                 1410             


His Leu  Trp Tyr Leu Leu Pro  Pro Thr Ala Ser Ile  Ser Arg Ala 
    1415                 1420                 1425             


Leu Ser  Met Tyr Glu Glu Ala  Phe Gln Asn Thr Ser  Asp Ser Asp 
    1430                 1435                 1440             


Arg Tyr  Ala Cys Ser Pro Leu  Pro Ser Tyr Leu Glu  Gly Ser Gly 
    1445                 1450                 1455             


Cys Val  Ile Ala Glu Glu Gln  Asn Ser Gln Thr Pro  Leu Arg Asp 
    1460                 1465                 1470             


Val Cys  Phe His Leu Leu Lys  Leu Tyr Ser Asp Arg  His Tyr Asp 
    1475                 1480                 1485             


Leu Asn  Gln Leu Leu Glu Pro  Arg Ser Ile Thr Ala  Asp Pro Leu 
    1490                 1495                 1500             


Asp Tyr  Arg Leu Ser Trp His  Leu Trp Glu Val Leu  Arg Ala Leu 
    1505                 1510                 1515             


Asn Tyr  Thr His Leu Ser Ala  Gln Cys Glu Gly Val  Leu Gln Ala 
    1520                 1525                 1530             


Ser Tyr  Ala Gly Gln Leu Glu  Ser Glu Gly Leu Trp  Glu Trp Ala 
    1535                 1540                 1545             


Ile Phe  Val Leu Leu His Ile  Asp Asn Ser Gly Ile  Arg Glu Lys 
    1550                 1555                 1560             


Ala Val  Arg Glu Leu Leu Thr  Arg His Cys Gln Leu  Leu Glu Thr 
    1565                 1570                 1575             


Pro Glu  Ser Trp Ala Lys Glu  Thr Phe Leu Thr Gln  Lys Leu Arg 
    1580                 1585                 1590             


Val Pro  Ala Lys Trp Ile His  Glu Ala Lys Ala Val  Arg Ala His 
    1595                 1600                 1605             


Met Glu  Ser Asp Lys His Leu  Glu Ala Leu Cys Leu  Phe Lys Ala 
    1610                 1615                 1620             


Glu His  Trp Asn Arg Cys His  Lys Leu Ile Ile Arg  His Leu Ala 
    1625                 1630                 1635             


Ser Asp  Ala Ile Ile Asn Glu  Asn Tyr Asp Tyr Leu  Lys Gly Phe 
    1640                 1645                 1650             


Leu Glu  Asp Leu Ala Pro Pro  Glu Arg Ser Ser Leu  Ile Gln Asp 
    1655                 1660                 1665             


Trp Glu  Thr Ser Gly Leu Val  Tyr Leu Asp Tyr Ile  Arg Val Ile 
    1670                 1675                 1680             


Glu Met  Leu Arg His Ile Gln  Gln Val Asp Cys Ser  Gly Asn Asp 
    1685                 1690                 1695             


Leu Glu  Gln Leu His Ile Lys  Val Thr Ser Leu Cys  Ser Arg Ile 
    1700                 1705                 1710             


Glu Gln  Ile Gln Cys Tyr Ser  Ala Lys Asp Arg Leu  Ala Gln Ser 
    1715                 1720                 1725             


Asp Met  Ala Lys Arg Val Ala  Asn Leu Leu Arg Val  Val Leu Ser 
    1730                 1735                 1740             


Leu His  His Pro Pro Asp Arg  Thr Ser Asp Ser Thr  Pro Asp Pro 
    1745                 1750                 1755             


Gln Arg  Val Pro Leu Arg Leu  Leu Ala Pro His Ile  Gly Arg Leu 
    1760                 1765                 1770             


Pro Met  Pro Glu Asp Tyr Ala  Met Asp Glu Leu Arg  Ser Leu Thr 
    1775                 1780                 1785             


Gln Ser  Tyr Leu Arg Glu Leu  Ala Val Gly Ser Leu  
    1790                 1795                 1800 


<210>  1711
<211>  6628
<212>  DNA
<213>  Homosapiens

<400>  1711
gcccaatgaa taacagggtc gacccagagt ggcggccgcg tccaccaatt cgcggacggc     60

gagggcggag cgtccgcaac gagcctctga cgccgggcgg cgtgtgacgc agtcgggccc    120

tctgcgcgct gcgcccgaag cggcggtcgg tggcaggggt ggtagcggcg gcggcgacgg    180

tttcgtgggg gccgcgcgct gctctgtgag cggcgggtgg cagcagggga ctcctgacac    240

ttccccttcc ccaccgaacc gcgctttctg aaacaaagac tcattttgaa gatgtttaac    300

aaatcatttg gaacaccctt tgggggtggc acaggtggct ttggcacaac ttcaacattt    360

ggacagaata ctggctttgg cactactagt ggaggggcat ttggaacatc tgcatttggt    420

tctagcaaca atactggagg cctctttgga aattcacaga ctaaaccagg aggattgttt    480

ggaaccagtt catttagcca gccagctacc tccacaagca ctggctttgg gtttggtacg    540

tcaacaggaa cagcaaatac cttgtttgga actgcaagca cagggaccag tctcttctca    600

tcccaaaaca atgcctttgc acaaaataaa ccaactggct ttggcaattt tggaaccagt    660

actagcagtg gaggactctt tggaaccaca aataccacct ctaatccttt tggcagcaca    720

tctggctccc tctttgggcc aagtagtttt acagctgctc ctactgggac tactattaaa    780

tttaaccctc caactggtac agatactatg gtcaaagctg gagttagcac taacataagt    840

accaagcacc agtgtattac tgctatgaaa gaatatgaaa gcaagtcact agaggaactt    900

cgtttagagg attatcaggc taacaggaag ggcccacaga accaggtggg agcaggtacc    960

acaactggct tgtttgggtc ttctccagcc acttccagcg caacaggact cttcagctcc   1020

tccaccacta attcaggctt tgcatatggt cagaacaaaa ctgcctttgg aactagtaca   1080

actggatttg gaacaaatcc aggtggtctc tttggccaac agaatcagca gactaccagc   1140

ctcttcagca aaccatttgg ccaggctaca accacccaga acactggctt ttcctttggt   1200

aataccagca ccataggaca gccaagcacc aacaccatgg gattatttgg agtaacccaa   1260

gcctcacagc ctggaggtct ttttgggaca gctacaaaca ccagcactgg gacagcattt   1320

ggaacaggaa caggtctctt tgggcagacc aatactggat ttggtgctgt tggttcgacc   1380

ctgtttggca ataacaagct tactacattt ggaagcagca caaccagtgc accttcattt   1440

ggtacaacca gtggcgggct ctttggtttt ggcacaaata ccagtgggaa tagtattttt   1500

ggaagtaaac cagcacctgg gactcttgga actgggcttg gtgcaggatt tggaacagct   1560

cttggtgctg gacaggcatc tttgtttggg aacaaccaac ctaagattgg agggcctctt   1620

ggtacaggag cctttggggc ccctggattt aatactacga cagccacttt gggctttgga   1680

gccccccagg ccccagtagc tttgacagat ccaaatgctt ctgctgccca gcaggctgtt   1740

ctccagcagc acatcaatag tctaacatac tcaccttttg gagactctcc tctcttccgg   1800

aatccgatgt cagaccctaa gaagaaggaa gagagattga aaccaacaaa tccagcagcc   1860

cagaaggctc ttactacacc tactcattat aaactgacac cccgccctgc cactagagtc   1920

cggccaaagg ctttacaaac aacaggcaca gccaagtcac atctctttga tgggctggat   1980

gacgatgaac catccctagc caatggagca ttcatgccca agaagagcat taagaagttg   2040

gttttgaaga accttaataa tagcaatctc ttttctcctg ttaatcgtga ttcagaaaat   2100

ctagcttcac catctgaata tccagaaaat ggagagagat ttagtttcct aagcaaacct   2160

gttgatgaga atcaccagca ggatggagat gaagattccc ttgtttcaca tttttatact   2220

aaccctattg ccaaacctat tcctcaaacc ccagaaagtg ctggaaataa acacagcaac   2280

agcaacagtg tggatgatac cattgttgca ttaaacatgc gtgctgcttt gcgaaatggg   2340

ctggaaggaa gcagtgaaga aacgtctttt catgatgagt cacttcagga tgaccgagaa   2400

gaaatagaaa ataattctta ccatatgcac ccagcaggta ttattctcac taaggttggt   2460

tactatacta ttccatctat ggatgacctt gctaaaatta ccaatgaaaa aggagagtgc   2520

attgtctctg atttcactat tggtcggaaa ggttatggtt caatctattt tgaaggagat   2580

gtgaatttga caaatctaaa tttggatgat attgtgcata tccggaggaa agaagtagtt   2640

gtctacttag atgataacca aaaaccacct gtgggtgaag ggctaaatag gaaggctgaa   2700

gttacattgg atggagtttg gccaacagat aaaacatctc gttgtttaat aaagagccca   2760

gatcgccttg ctgatatcaa ctatgaagga agattggaag cagtttcaag gaaacaggga   2820

gctcaattca aagaataccg gcctgaaact ggttcttggg tgtttaaggt ctcccatttt   2880

tctaagtatg gccttcagga ttctgatgaa gaggaggagg agcatccgtc taaaactagt   2940

acaaagaagt tgaagactgc tcctttgcct cctgcaagcc agactacgcc cttgcagatg   3000

gctcttaatg gcaaacctgc acctccacct cagagccaga gcccagaggt ggagcagtta   3060

gggagggttg tggaactgga cagtgacatg gtagatatca cccaggagcc agttttggat   3120

accatgttag aagagagcat gcctgaggat caggaacctg tgtctgcctc aacacatatt   3180

gcatcttcac tgggaattaa tccacatgtc ttacagatca tgaaagcatc attgcttact   3240

gatgaagaag atgtagatat ggcactggat caacgcttca gtcgcctgcc ttccaaagca   3300

gatacttctc aagaaatctg ttctcccaga ctccccattt cagcatccca ctcgtcgaaa   3360

actcgttcac tagttggtgg gttactacaa tcaaaattta caagtggagc ttttctttca   3420

ccaagtgtct ctgtgcaaga atgtcgtact cccagagcag catctttaat gaatatccca   3480

tccacatcct cttggtctgt ccctccaccc ctgacttctg tgttcacaat gcccagccca   3540

gcccctgagg ttccgttgaa aacagtgggt acacgtaggc aactaggcct agtccctcgt   3600

gaaaagtctg tcacctatgg caagggaaaa ctcttgatgg acatggccct attcatggga   3660

cgctcatttc gtgttggttg gggccccaac tggactcttg ctaatagtgg agaacagctg   3720

aatggctctc atgaactaga aaatcatcag attgccgatt ccatggagtt tggattcctg   3780

cccaatccag tagctgttaa acccctaact gagtccccat tcaaagttca cttagaaaaa   3840

ctcagtttga gacaaagaaa gccagatgaa gacatgaaat tatatcagac acctctggag   3900

ctcaaattaa aacacagcac tgtccatgtg gatgaactgt gtcctctcat tgtccccaat   3960

ctgggagttg ctgtcattca tgactatgca gattgggtta aagaagcatc aggagactta   4020

ccagaagcac aaattgtgaa gcactggagc ctgacatgga cactatgtga agccctatgg   4080

ggccacctga aggagcttga cagccagcta aatgaacccc gtgaatacat tcaaattctg   4140

gagcgaagaa gagctttctc ccgctggcta tcctgtactg ccacacctca gattgaagag   4200

gaagtctcct taacccaaaa aaacagccct gtggaggctg tattcagcta cctcacaggc   4260

aaaaggatca gtgaggcctg ctctctggcc cagcagtcag gggatcatcg tcttgctctt   4320

cttttatctc agtttgtggg tagccagtca gtccgggagc tgctcaccat gcagttggtg   4380

gactggcatc agctccaagc agactccttc atccaggatg agagactgcg catctttgct   4440

ctgttggctg gaaaaccggt gtggcagctc tcagaaaaga agcaaataaa cgtgtgctcc   4500

cagttggatt ggaaacgctc cctggctatc catctttggt atttgcttcc accaacagcc   4560

tccatttcta gggcgctcag catgtatgaa gaagcatttc agaatacctc tgacagtgac   4620

agatatgcct gctccccact tccttcgtat ctggagggtt ctggctgtgt gatagcggag   4680

gagcaaaact cacagacacc acttcgagat gtctgctttc accttctaaa actctacagt   4740

gacagcatac gtgagaaggc tgttcgagag ctgcttaccc ggcactgcca gctgttggag   4800

acccctgaat cttgggctaa agagactttc cttacccaga agctccgtgt acctgccaaa   4860

tggatccacg aggccaaagc tgtgcgagca cacatggaat ctgacaagca cttagaggcc   4920

ctttgcttat ttaaggctga gcactggaac cgctgccaca agctcatcat ccgacactta   4980

gcttctgatg ccatcattaa tgagaactat gactacctga aggggttctt ggaagacctg   5040

gcacctccag agcgcagcag cctaattcag gattgggaaa catctgggct tgtttacctg   5100

gactatatta gagtcattga aatgctccgc catatacagc aggtggattg ctcaggtaat   5160

gacctggagc agttacacat caaagtgact tcactgtgca gtcggataga gcagattcag   5220

tgttacagtg ctaaagatcg cctggctcag tcagacatgg ccaaacgtgt agccaacctg   5280

ctgcgcgtgg tgctgagtct gcatcatcct cctgatagaa cctccgactc aacaccagac   5340

cctcagcgag tccctttgcg cctcttggct ccccacattg gccggcttcc catgcctgag   5400

gactatgcca tggacgaact gcgcagcctt acccagtcct atctgcgaga actggctgtt   5460

gggagcctgt gagccccagg cactttgcat cacagtcaca tgcccattca caccacacag   5520

aggttccctg ccttgtttgg attggcactg tttgccattc tctgggttgg ctgtggcatc   5580

taccctccct ccctgctgcc agaagcagca tcctccactt gttcagggct tttcttaata   5640

ctgaacgtag cataagggct tctggaaccc agaagaggag acagtttacc atcctcaaga   5700

tcattcagtg tttttccttt aaaaaaatgg tcaataaagc tcctttggca gaatccccca   5760

aagaaccagg gtattctttt tccatcccta gccattctgg atcttgtgac cctccatgcc   5820

aaccagcttc cctactccta ccctggccct tttatactag gactccttag gaggagtgag   5880

acaggtgata atggatcctt aacagatgaa ctatccacag aaggaagagg gatccgtctc   5940

ttaagtaatt ggttagttaa cactgaattt tggaggcaaa ggagggttgg cctgagttag   6000

gaaacaaaat gggatctttc tgacacactt agggcagaag tgaatgcctg tcacggaggg   6060

attgatcttc agggctgttt ttgttcctgc ctttagagtt ccatgaacac catacctttg   6120

ctactactat gtgcaggaac ccttggtcac atgtgacatg tctgtgggaa gctcccagag   6180

tttggtttgg tccctggttt tcagtcttgc tgagactctg tctggatttg cctgcagagt   6240

ttggataaaa aatggcaggt tgggtaaccc tccctgttca tcccatgtta gctccaaagc   6300

atttcccacc ctccatctac cccttccaga agcaaaaaca aaccatgact gaggcaggca   6360

tggagttggg cgttaggggc aggcagaggg cctttgctac actgctgaca gctataggga   6420

gccccaggta atggcatgag atagctggtg ttagggctat ctcaggcaat atggccacac   6480

ctgggtcttt atgcatgaag ataatgtaaa ggtttttatt aaaaaatata tatatgtata   6540

aataaatgat ctagatattt tcctcttttt ctgaagctac tttcttaaaa aataaataaa   6600

atgtttatag cattcctggt aaaaaaaa                                      6628


<210>  1712
<211>  1726
<212>  PRT
<213>  Homosapiens

<400>  1712

Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly 
1               5                   10                  15      


Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr 
            20                  25                  30          


Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr 
        35                  40                  45              


Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly 
    50                  55                  60                  


Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly 
65                  70                  75                  80  


Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn 
            100                 105                 110         


Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly 
        115                 120                 125             


Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr 
145                 150                 155                 160 


Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala 
                165                 170                 175     


Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met 
            180                 185                 190         


Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr 
        195                 200                 205             


Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr 
    210                 215                 220                 


Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu 
225                 230                 235                 240 


Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys 
                245                 250                 255     


Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly 
            260                 265                 270         


Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro 
        275                 280                 285             


Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn 
    290                 295                 300                 


Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly 
305                 310                 315                 320 


Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn 
                325                 330                 335     


Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln 
            340                 345                 350         


Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn 
        355                 360                 365             


Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly 
    370                 375                 380                 


Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn 
385                 390                 395                 400 


Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu 
                405                 410                 415     


Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe 
            420                 425                 430         


Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe 
        435                 440                 445             


Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala 
    450                 455                 460                 


Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln 
465                 470                 475                 480 


Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe 
                485                 490                 495     


Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys 
            500                 505                 510         


Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr 
        515                 520                 525             


Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg 
    530                 535                 540                 


Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp 
545                 550                 555                 560 


Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro 
                565                 570                 575     


Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn 
            580                 585                 590         


Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser 
        595                 600                 605             


Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val 
    610                 615                 620                 


Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His 
625                 630                 635                 640 


Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser 
                645                 650                 655     


Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val 
            660                 665                 670         


Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser 
        675                 680                 685             


Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu 
    690                 695                 700                 


Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr 
705                 710                 715                 720 


Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile 
                725                 730                 735     


Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg 
            740                 745                 750         


Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn 
        755                 760                 765             


Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val 
    770                 775                 780                 


Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg 
785                 790                 795                 800 


Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser 
                805                 810                 815     


Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu 
            820                 825                 830         


Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu 
        835                 840                 845             


Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser 
    850                 855                 860                 


Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser 
865                 870                 875                 880 


Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro 
            900                 905                 910         


Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu 
        915                 920                 925             


Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr 
    930                 935                 940                 


Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser 
945                 950                 955                 960 


Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile 
                965                 970                 975     


Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu 
            980                 985                 990         


Asp Gln Arg Phe Ser Arg Leu Pro  Ser Lys Ala Asp Thr  Ser Gln Glu 
        995                 1000                 1005             


Ile Cys  Ser Pro Arg Leu Pro  Ile Ser Ala Ser His  Ser Ser Lys 
    1010                 1015                 1020             


Thr Arg  Ser Leu Val Gly Gly  Leu Leu Gln Ser Lys  Phe Thr Ser 
    1025                 1030                 1035             


Gly Ala  Phe Leu Ser Pro Ser  Val Ser Val Gln Glu  Cys Arg Thr 
    1040                 1045                 1050             


Pro Arg  Ala Ala Ser Leu Met  Asn Ile Pro Ser Thr  Ser Ser Trp 
    1055                 1060                 1065             


Ser Val  Pro Pro Pro Leu Thr  Ser Val Phe Thr Met  Pro Ser Pro 
    1070                 1075                 1080             


Ala Pro  Glu Val Pro Leu Lys  Thr Val Gly Thr Arg  Arg Gln Leu 
    1085                 1090                 1095             


Gly Leu  Val Pro Arg Glu Lys  Ser Val Thr Tyr Gly  Lys Gly Lys 
    1100                 1105                 1110             


Leu Leu  Met Asp Met Ala Leu  Phe Met Gly Arg Ser  Phe Arg Val 
    1115                 1120                 1125             


Gly Trp  Gly Pro Asn Trp Thr  Leu Ala Asn Ser Gly  Glu Gln Leu 
    1130                 1135                 1140             


Asn Gly  Ser His Glu Leu Glu  Asn His Gln Ile Ala  Asp Ser Met 
    1145                 1150                 1155             


Glu Phe  Gly Phe Leu Pro Asn  Pro Val Ala Val Lys  Pro Leu Thr 
    1160                 1165                 1170             


Glu Ser  Pro Phe Lys Val His  Leu Glu Lys Leu Ser  Leu Arg Gln 
    1175                 1180                 1185             


Arg Lys  Pro Asp Glu Asp Met  Lys Leu Tyr Gln Thr  Pro Leu Glu 
    1190                 1195                 1200             


Leu Lys  Leu Lys His Ser Thr  Val His Val Asp Glu  Leu Cys Pro 
    1205                 1210                 1215             


Leu Ile  Val Pro Asn Leu Gly  Val Ala Val Ile His  Asp Tyr Ala 
    1220                 1225                 1230             


Asp Trp  Val Lys Glu Ala Ser  Gly Asp Leu Pro Glu  Ala Gln Ile 
    1235                 1240                 1245             


Val Lys  His Trp Ser Leu Thr  Trp Thr Leu Cys Glu  Ala Leu Trp 
    1250                 1255                 1260             


Gly His  Leu Lys Glu Leu Asp  Ser Gln Leu Asn Glu  Pro Arg Glu 
    1265                 1270                 1275             


Tyr Ile  Gln Ile Leu Glu Arg  Arg Arg Ala Phe Ser  Arg Trp Leu 
    1280                 1285                 1290             


Ser Cys  Thr Ala Thr Pro Gln  Ile Glu Glu Glu Val  Ser Leu Thr 
    1295                 1300                 1305             


Gln Lys  Asn Ser Pro Val Glu  Ala Val Phe Ser Tyr  Leu Thr Gly 
    1310                 1315                 1320             


Lys Arg  Ile Ser Glu Ala Cys  Ser Leu Ala Gln Gln  Ser Gly Asp 
    1325                 1330                 1335             


His Arg  Leu Ala Leu Leu Leu  Ser Gln Phe Val Gly  Ser Gln Ser 
    1340                 1345                 1350             


Val Arg  Glu Leu Leu Thr Met  Gln Leu Val Asp Trp  His Gln Leu 
    1355                 1360                 1365             


Gln Ala  Asp Ser Phe Ile Gln  Asp Glu Arg Leu Arg  Ile Phe Ala 
    1370                 1375                 1380             


Leu Leu  Ala Gly Lys Pro Val  Trp Gln Leu Ser Glu  Lys Lys Gln 
    1385                 1390                 1395             


Ile Asn  Val Cys Ser Gln Leu  Asp Trp Lys Arg Ser  Leu Ala Ile 
    1400                 1405                 1410             


His Leu  Trp Tyr Leu Leu Pro  Pro Thr Ala Ser Ile  Ser Arg Ala 
    1415                 1420                 1425             


Leu Ser  Met Tyr Glu Glu Ala  Phe Gln Asn Thr Ser  Asp Ser Asp 
    1430                 1435                 1440             


Arg Tyr  Ala Cys Ser Pro Leu  Pro Ser Tyr Leu Glu  Gly Ser Gly 
    1445                 1450                 1455             


Cys Val  Ile Ala Glu Glu Gln  Asn Ser Gln Thr Pro  Leu Arg Asp 
    1460                 1465                 1470             


Val Cys  Phe His Leu Leu Lys  Leu Tyr Ser Asp Ser  Ile Arg Glu 
    1475                 1480                 1485             


Lys Ala  Val Arg Glu Leu Leu  Thr Arg His Cys Gln  Leu Leu Glu 
    1490                 1495                 1500             


Thr Pro  Glu Ser Trp Ala Lys  Glu Thr Phe Leu Thr  Gln Lys Leu 
    1505                 1510                 1515             


Arg Val  Pro Ala Lys Trp Ile  His Glu Ala Lys Ala  Val Arg Ala 
    1520                 1525                 1530             


His Met  Glu Ser Asp Lys His  Leu Glu Ala Leu Cys  Leu Phe Lys 
    1535                 1540                 1545             


Ala Glu  His Trp Asn Arg Cys  His Lys Leu Ile Ile  Arg His Leu 
    1550                 1555                 1560             


Ala Ser  Asp Ala Ile Ile Asn  Glu Asn Tyr Asp Tyr  Leu Lys Gly 
    1565                 1570                 1575             


Phe Leu  Glu Asp Leu Ala Pro  Pro Glu Arg Ser Ser  Leu Ile Gln 
    1580                 1585                 1590             


Asp Trp  Glu Thr Ser Gly Leu  Val Tyr Leu Asp Tyr  Ile Arg Val 
    1595                 1600                 1605             


Ile Glu  Met Leu Arg His Ile  Gln Gln Val Asp Cys  Ser Gly Asn 
    1610                 1615                 1620             


Asp Leu  Glu Gln Leu His Ile  Lys Val Thr Ser Leu  Cys Ser Arg 
    1625                 1630                 1635             


Ile Glu  Gln Ile Gln Cys Tyr  Ser Ala Lys Asp Arg  Leu Ala Gln 
    1640                 1645                 1650             


Ser Asp  Met Ala Lys Arg Val  Ala Asn Leu Leu Arg  Val Val Leu 
    1655                 1660                 1665             


Ser Leu  His His Pro Pro Asp  Arg Thr Ser Asp Ser  Thr Pro Asp 
    1670                 1675                 1680             


Pro Gln  Arg Val Pro Leu Arg  Leu Leu Ala Pro His  Ile Gly Arg 
    1685                 1690                 1695             


Leu Pro  Met Pro Glu Asp Tyr  Ala Met Asp Glu Leu  Arg Ser Leu 
    1700                 1705                 1710             


Thr Gln  Ser Tyr Leu Arg Glu  Leu Ala Val Gly Ser  Leu 
    1715                 1720                 1725     


<210>  1713
<211>  1825
<212>  DNA
<213>  Homosapiens

<400>  1713
agaaaggaac acagtaaact gaattgatcc gtttagaagt ttacaatgaa gtttcttcta     60

atactgctcc tgcaggccac tgcttctgga gctcttcccc tgaacagctc tacaagcctg    120

gaaaaaaata atgtgctatt tggtgaaaga tacttagaaa aattttatgg ccttgagata    180

aacaaacttc cagtgacaaa aatgaaatat agtggaaact taatgaagga aaaaatccaa    240

gaaatgcagc acttcttggg tctgaaagtg accgggcaac tggacacatc taccctggag    300

atgatgcacg cacctcgatg tggagtcccc gatgtccatc atttcaggga aatgccaggg    360

gggcccgtat ggaggaaaca ttatatcacc tacagaatca ataattacac acctgacatg    420

aaccgtgagg atgttgacta cgcaatccgg aaagctttcc aagtatggag taatgttacc    480

cccttgaaat tcagcaagat taacacaggc atggctgaca ttttggtggt ttttgcccgt    540

ggagctcatg gagacttcca tgcttttgat ggcaaaggtg gaatcctagc ccatgctttt    600

ggacctggat ctggcattgg aggggatgca catttcgatg aggacgaatt ctggactaca    660

cattcaggag gcacaaactt gttcctcact gctgttcacg agattggcca ttccttaggt    720

cttggccatt ctagtgatcc aaaggccgta atgttcccca cctacaaata tgttgacatc    780

aacacatttc gcctctctgc tgatgacata cgtggcattc agtccctgta tggagaccca    840

aaagagaacc aacgcttgcc aaatcctgac aattcagaac cagctctctg tgaccccaat    900

ttgagttttg atgctgtcac taccgtggga aataagatct ttttcttcaa agacaggttc    960

ttctggctga aggtttctga gagaccaaag accagtgtta atttaatttc ttccttatgg   1020

ccaaccttgc catctggcat tgaagctgct tatgaaattg aagccagaaa tcaagttttt   1080

ctttttaaag atgacaaata ctggttaatt agcaatttaa gaccagagcc aaattatccc   1140

aagagcatac attcttttgg ttttcctaac tttgtgaaaa aaattgatgc agctgttttt   1200

aacccacgtt tttataggac ctacttcttt gtagataacc agtattggag gtatgatgaa   1260

aggagacaga tgatggaccc tggttatccc aaactgatta ccaagaactt ccaaggaatc   1320

gggcctaaaa ttgatgcagt cttctactct aaaaacaaat actactattt cttccaagga   1380

tctaaccaat ttgaatatga cttcctactc caacgtatca ccaaaacact gaaaagcaat   1440

agctggtttg gttgttagaa atggtgtaat taatggtttt tgttagttca cttcagctta   1500

ataagtattt attgcatatt tgctatgtcc tcagtgtacc actacttaga gatatgtatc   1560

ataaaaataa aatctgtaaa ccataggtaa tgattatata aaatacataa tatttttcaa   1620

ttttgaaaac tctaattgtc cattcttgct tgactctact attaagtttg aaaatagtta   1680

ccttcaaagg ccaagagaat tctatttgaa gcatgctctg taagttgctt cctaacatcc   1740

ttggactgag aaattatact tacttctggc ataactaaaa ttaagtatat atattttggc   1800

tcaaataaaa ttgaaaaaaa aatca                                         1825


<210>  1714
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  1714

Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe 
            20                  25                  30          


Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu 
        35                  40                  45              


Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile 
    50                  55                  60                  


Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp 
65                  70                  75                  80  


Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His 
            100                 105                 110         


Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu 
        115                 120                 125             


Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu 
145                 150                 155                 160 


Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly 
                165                 170                 175     


Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr 
225                 230                 235                 240 


Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro 
            260                 265                 270         


Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe 
        275                 280                 285             


Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg 
    290                 295                 300                 


Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu 
305                 310                 315                 320 


Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr 
                325                 330                 335     


Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr 
            340                 345                 350         


Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile 
        355                 360                 365             


His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val 
    370                 375                 380                 


Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr 
385                 390                 395                 400 


Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys 
                405                 410                 415     


Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln 
        435                 440                 445             


Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser 
    450                 455                 460                 


Asn Ser Trp Phe Gly Cys 
465                 470 


<210>  1715
<211>  2722
<212>  DNA
<213>  Homosapiens

<400>  1715
caacagtccc caggcatcac cattcaagat gcatccaggg gtcctggctg ccttcctctt     60

cttgagctgg actcattgtc gggccctgcc ccttcccagt ggtggtgatg aagatgattt    120

gtctgaggaa gacctccagt ttgcagagcg ctacctgaga tcatactacc atcctacaaa    180

tctcgcggga atcctgaagg agaatgcagc aagctccatg actgagaggc tccgagaaat    240

gcagtctttc ttcggcttag aggtgactgg caaacttgac gataacacct tagatgtcat    300

gaaaaagcca agatgcgggg ttcctgatgt gggtgaatac aatgttttcc ctcgaactct    360

taaatggtcc aaaatgaatt taacctacag aattgtgaat tacacccctg atatgactca    420

ttctgaagtc gaaaaggcat tcaaaaaagc cttcaaagtt tggtccgatg taactcctct    480

gaattttacc agacttcacg atggcattgc tgacatcatg atctcttttg gaattaagga    540

gcatggcgac ttctacccat ttgatgggcc ctctggcctg ctggctcatg cttttcctcc    600

tgggccaaat tatggaggag atgcccattt tgatgatgat gaaacctgga caagtagttc    660

caaaggctac aacttgtttc ttgttgctgc gcatgagttc ggccactcct taggtcttga    720

ccactccaag gaccctggag cactcatgtt tcctatctac acctacaccg gcaaaagcca    780

ctttatgctt cctgatgacg atgtacaagg gatccagtct ctctatggtc caggagatga    840

agaccccaac cctaaacatc caaaaacgcc agacaaatgt gacccttcct tatcccttga    900

tgccattacc agtctccgag gagaaacaat gatctttaaa gacagattct tctggcgcct    960

gcatcctcag caggttgatg cggagctgtt tttaacgaaa tcattttggc cagaacttcc   1020

caaccgtatt gatgctgcat atgagcaccc ttctcatgac ctcatcttca tcttcagagg   1080

tagaaaattt tgggctctta atggttatga cattctggaa ggttatccca aaaaaatatc   1140

tgaactgggt cttccaaaag aagttaagaa gataagtgca gctgttcact ttgaggatac   1200

aggcaagact ctcctgttct caggaaacca ggtctggaga tatgatgata ctaaccatat   1260

tatggataaa gactatccga gactaataga agaagacttc ccaggaattg gtgataaagt   1320

agatgctgtc tatgagaaaa atggttatat ctattttttc aacggaccca tacagtttga   1380

atacagcatc tggagtaacc gtattgttcg cgtcatgcca gcaaattcca ttttgtggtg   1440

ttaagtgtct ttttaaaaat tgttatttaa atcctgaaga gcatttgggg taatacttcc   1500

agaagtgcgg ggtaggggaa gaagagctat caggagaaag cttggttctg tgaacaagct   1560

tcagtaagtt atctttgaat atgtagtatc tatatgacta tgcgtggctg gaaccacatt   1620

gaagaatgtt agagtaatga aatggaggat ctctaaagag catctgattc ttgttgctgt   1680

acaaaagcaa tggttgatga tacttcccac accacaaatg ggacacatgg tctgtcaatg   1740

agagcataat ttaaaaatat atttataagg aaattttaca agggcataaa gtaaatacat   1800

gcatataatg aataaatcat tcttactaaa aagtataaaa tagtatgaaa atggaaattt   1860

gggagagcca tacataaaag aaataaacca aaggaaaatg tctgtaataa tagactgtaa   1920

cttccaaata aataattttc attttgcact gaggatattc agatgtatgt gcccttcttc   1980

acacagacac taacgaaata tcaaagtcat taaagacagg agacaaaaga gcagtggtaa   2040

gaatagtaga tgtggccttt gaattctgtt taattttcac ttttggcaat gactcaaagt   2100

ctgctctcat ataagacaaa tattcctttg catattataa aggataaaga aggatgatgt   2160

ctttttatta aaatatttca ggttcttcag aagtcacaca ttacaaagtt aaaattgtta   2220

tcaaaatagt ctaaggccat ggcatccctt tttcataaat tatttgatta tttaagacta   2280

aaagttgcat tttaacccta ttttacctag ctaattattt aattgtccgg tttgtcttgg   2340

atatataggc tattttctaa agacttgtat agcatgaaat aaaatatatc ttataaagtg   2400

gaagtatgta tattaaaaaa gagacatcca aatttttttt taaagcagtc tactagattg   2460

tgatcccttg agatatggaa ggatgccttt ttttctctgc atttaaaaaa atcccccagc   2520

acttcccaca gtgcctattg atacttgggg agggtgcttg gcacttattg aatatatgat   2580

cggccatcaa gggaagaact attgtgctca gagacactgt tgataaaaac tcaggcaaag   2640

aaaatgaaat gcatatttgc aaagtgtatt aggaagtgtt tatgttgttt ataataaaaa   2700

tatattttca acagaaaaaa aa                                            2722


<210>  1716
<211>  471
<212>  PRT
<213>  Homosapiens

<400>  1716

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  1717
<211>  1277
<212>  DNA
<213>  Homosapiens

<400>  1717
ctgccgcgct gtccgcgtta tctcctcccg gtgagaacga accgcagtgt ccaccggcga     60

ggagccagcc ctgtcccggt cagagaaaga cgacgaggat acctgggagc gggcggcggc    120

cgggctgggc cgcgccggtg cgggctggcg actctgctcc tccgcttgct gctgtctctg    180

ggaactgggt gccagcgctg aggggcttcc agcggacagg gacccccttc cccggctccc    240

ctgcccaccc tgccggggag ggcggaagat gccggtgaag aagaagagaa aatcccctgg    300

ggtggcagca gcagtagcgg aagacggagg cctcaaaaag tgtaaaatct ccagctattg    360

cagatcccaa ccccctgcta gactaataag tggagaggaa catttttcaa gcaagaagtg    420

cctggcttgg ttttatgaat atgcaggtcc tgatgaagtt gtagggccag aaggaatgga    480

aaaattttgt gaagacattg gtgttgaacc tgaaaatatt attatgttag ttttagcgtg    540

gaaattggag gctgaaagca tgggattttt taccaaggaa gaatggttaa agggaatgac    600

ttcattacag tgtgactgca cagaaaagtt acaaaacaaa tttgactttt tgcgctcaca    660

gttgaatgat atttcgtcat ttaagaatat ctacagatat gcctttgatt ttgcaaggga    720

taaagatcag agaagccttg atattgatac tgctaaatct atgttagctc ttctgcttgg    780

gaggacatgg ccactgtttt cagtatttta ccagtacctg gagcaatcaa agtatcgtgt    840

tatgaacaaa gatcaatggt acaatgtatt agaattcagc agaacagtcc atgctgatct    900

tagtaactat gatgaagatg gtgcttggcc tgttcttctt gatgaatttg ttgagtggca    960

aaaagtccgt cagacatcat agcaagaact atgtgaagaa aatgcaaacc tttcaattcc   1020

cacgtgtata caagctaatg tgatgagggg gaaaaaaatc caacgggtgc attttcattc   1080

atatgaaaga cttctcatag tacttttttt tccttttttt aaaggaggtt tttcttgtta   1140

catgtgatgg gcattgagcc acacctcttc ttagactgaa tattgaagtt tttgttttga   1200

gttatgttta taacatttat ttcagaacaa taaagattca gatttgtgaa aaaaaaaaaa   1260

aaaaaaaaaa aaaaaaa                                                  1277


<210>  1718
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  1718

Met Pro Val Lys Lys Lys Arg Lys Ser Pro Gly Val Ala Ala Ala Val 
1               5                   10                  15      


Ala Glu Asp Gly Gly Leu Lys Lys Cys Lys Ile Ser Ser Tyr Cys Arg 
            20                  25                  30          


Ser Gln Pro Pro Ala Arg Leu Ile Ser Gly Glu Glu His Phe Ser Ser 
        35                  40                  45              


Lys Lys Cys Leu Ala Trp Phe Tyr Glu Tyr Ala Gly Pro Asp Glu Val 
    50                  55                  60                  


Val Gly Pro Glu Gly Met Glu Lys Phe Cys Glu Asp Ile Gly Val Glu 
65                  70                  75                  80  


Pro Glu Asn Ile Ile Met Leu Val Leu Ala Trp Lys Leu Glu Ala Glu 
                85                  90                  95      


Ser Met Gly Phe Phe Thr Lys Glu Glu Trp Leu Lys Gly Met Thr Ser 
            100                 105                 110         


Leu Gln Cys Asp Cys Thr Glu Lys Leu Gln Asn Lys Phe Asp Phe Leu 
        115                 120                 125             


Arg Ser Gln Leu Asn Asp Ile Ser Ser Phe Lys Asn Ile Tyr Arg Tyr 
    130                 135                 140                 


Ala Phe Asp Phe Ala Arg Asp Lys Asp Gln Arg Ser Leu Asp Ile Asp 
145                 150                 155                 160 


Thr Ala Lys Ser Met Leu Ala Leu Leu Leu Gly Arg Thr Trp Pro Leu 
                165                 170                 175     


Phe Ser Val Phe Tyr Gln Tyr Leu Glu Gln Ser Lys Tyr Arg Val Met 
            180                 185                 190         


Asn Lys Asp Gln Trp Tyr Asn Val Leu Glu Phe Ser Arg Thr Val His 
        195                 200                 205             


Ala Asp Leu Ser Asn Tyr Asp Glu Asp Gly Ala Trp Pro Val Leu Leu 
    210                 215                 220                 


Asp Glu Phe Val Glu Trp Gln Lys Val Arg Gln Thr Ser 
225                 230                 235         


<210>  1719
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1719
atggcgaacg ggactgcgga cgttcggaag ctcttcatct tcactactac ccagaattac     60

ttcgggttga tgtctgaact ctgggatcag ccactgttgt gcaactgtct tgaaatcaac    120

aacttcttgg atgacggcaa ccagatgctc ctcagggtgc agcgatccga cgcaggaatc    180

tccttttcca acacgattga gtttggtgac acaaaagata aagtgctggt gtttttcaag    240

ctgcgacctg aagtaattac tgatgagaat ctacatgata acattcttgt ttcatctatg    300

ttagagtcac ctattagttc tctttaccaa gcagtacggc aagtattcgc accaatgttg    360

ttaaaggatc aggaatggag cagaaacttt gatcccaaac ttcagaatct tttgagtgaa    420

ctagaagctg ggttgggtat agttctacga agatcagaca ctaacttaac aaaattgaaa    480

tttaaggaag atgacacacg aggtatcctt acaccaagcg atgagttcca gttttggata    540

gaacaagctc accgtggaaa taaacagatt agtaaagaaa gagccaatta ttttaaagaa    600

ttatttgaaa caattgcaag agagttttat aacttggaca gtctatcctt actagaagtt    660

gttgacttgg tggagactac tcaggatgtt gtagatgatg tgtggagaca aacagaacat    720

gatcattatc ctgagtcacg aatgttgcat ctcttagaca tcataggtgg ttcatttgga    780

aggtttgttc agaaaaagtt gggaactttg aacctgtggg aagatcctta ttatcttgtg    840

aaagaaagtc tgaaagctgg tatttcaatt tgtgaacagt gggtgatagt ctgtaatcat    900

ctaacaggtc aggtgtggca gcgctatgtt cctcatccat ggaaaaatga aaaatatttt    960

ccagaaacac ttgacaaact tggcaaacgc cttgaagagg tcttggctat tagaacaatt   1020

catgagaagt ttctctattt tctacctgcc agtgaagaga aaatcatatg cctcactcga   1080

gtatttgaac cttttactgg cctgaatcct gtgcaatata atccatatac tgagcccttg   1140

tggaaagctg cggtgtctca atatgaaaag attattgcac ctgcggaaca aaaaatagca   1200

ggaaaattga aaaattatat ttcagaaatt caagacagtc cacagcagct tcttcaagca   1260

ttcctgaaat ataaagagtt ggtaaagcgt ccaactataa gcaaagaatt gatgttagaa   1320

agagaaactt tactggcaag acttgtggac tcaattaaag attttcgatt agactttgag   1380

aatcggtgcc gaggaattcc tggtgatgca tctggaccac tttctggcaa aaatctttca   1440

gaagttgtca acagtatagt ttgggttcgc cagttggaat tgaaggtaga tgatactatc   1500

aagattgcag aggctctttt atctgacttg ccaggatttc gatgtttcca tcaaagtgcc   1560

aaagatctct tagaccagct taaactatat gaacaggaac aatttgatga ttggtccagg   1620

gatattcaat caggtttatc tgattccaga tctggtttgt gtattgaggc tagtagtcga   1680

attatggaat tggattctaa tgatggatta ctaaaagtgc attattcaga tcgtttggtg   1740

attcttctga gagaagttcg tcagctctct gcacttggct ttgttattcc tgccaaaata   1800

cagcaagttg caaacattgc acagaaattc tgcaagcaag caattattct taaacaagtg   1860

gcacattttt ataattctat tgatcaacaa atgattcaaa gtcagaggcc aatgatgtta   1920

caatctgcct tagcatttga acagataatt aagaattcaa aagcaggaag tggagggaaa   1980

tcacagataa cttgggataa tcctaaagaa ttagaaggct atatccaaaa actccaaaat   2040

gctgctgaac ggcttgccac tgaaaataga aaactgagaa aatggcacac tacattttgt   2100

gaaaaggtgg ttgttcttat gaatattgat ctgcttcggc agcaacagcg ctggaaagat   2160

ggattacaag aattgagaac tggcttagca actgtagaag cacagggatt ccaagcaagt   2220

gacatgcatg catggaaaca acactggaat catcaactgt acaaagctct ggagcatcag   2280

taccagatgg gcttagaagc acttaatgag aatttgccag aaataaatat agacttaact   2340

tacaaacagg gacgattaca attcaggccc ccttttgaag aaatccgggc taaatattat   2400

agagaaatga agagattcat cggcattcca aatcagttta agggagtggg tgaggcagga   2460

gatgaatcta ttttttctat tatgattgat agaaatgcaa gtggattttt gacgattttc   2520

agcaaagcag aagatctgtt tagaagattg tcagctgttt tacaccaaca taaggaatgg   2580

attgtaattg ggcaagttga tatggaagct ctggtggaaa agcatctttt tactgtacat   2640

gattgggaga aaaattttaa agcattaaaa ataaagggga aagaagtaga acgacttcca   2700

agtgctgtca aggtagattg tttaaatatt aattgcaacc ctgtgaagac tgtgattgat   2760

gatctcatcc agaagttatt tgatctgctt gttctttctt tgaagaagtc catacaggct   2820

catttacatg aaattgatac atttgttact gaggctatgg aagtcttaac aattatgccc   2880

cagtctgtgg aagaaattgg tgatgcaaat ctacaatata gtaagttaca agaacggaag   2940

ccagagattt tgcccttatt tcaagaagct gaagacaaaa acagactttt acgaactgtg   3000

gctggtggag gtttagaaac aattagtaat ttgaaagcca agtgggataa atttgagtta   3060

atgatggaaa gtcaccaact tatgattaaa gaccagattg aagtgatgaa aggaaatgtg   3120

aaatcacgtc ttcagatcta ttatcaagaa ctggaaaaat ttaaagctcg ttgggaccaa   3180

ctaaagcctg gtgatgatgt tattgaaact ggccaacata atactcttga taaaagtgca   3240

aagttaataa aagagaaaaa aattgagttt gatgatcttg aagtcacaag aaaaaagctg   3300

gttgatgatt gccatcattt tagactggaa gagcctaatt tctccctggc aagtagtatc   3360

tctaaagata tcgagagctg tgcccaaatt tgggcctttt atgaagagtt tcaacaagga   3420

tttcaggaaa tggccaatga agactggatc acttttcgga ctaagacata cctgtttgag   3480

gaatttttga tgaactggca tgacagatta aggaaggttg aagaacattc agtgatgaca   3540

gtgaaattac aatcagaggt tgacaaatat aaaatcgtaa ttcctatctt gaaatatgtg   3600

agaggggagc atctttctcc agatcactgg cttgaccttt ttcgtctcct tggacttcct   3660

agggggacta gtctagagaa actactgttt ggtgatttgc tcagagtagc tgatacaatt   3720

gtagccaaag ctgccgacct taaagattta aatagtcggg cacaaggtga agttacaatc   3780

agagaagctt tacgtgaact tgatctttgg ggagttggag cagtgtttac attaattgat   3840

tatgaagaca gccaaagtcg aactatgaag ctgattaaag actggaaaga tatagtaaat   3900

caggttggag ataatagatg ccttctccaa tccttaaagg attctcctta ttataaagga   3960

tttgaagata aagtatcaat ttgggaaaga aaacttgcag agttagatga atacctgcag   4020

aatttaaatc atattcagag aaagtgggtg tatttggaac ccattttcgg ccgtggagca   4080

ttgccaaaag aacagacacg cttcaacaga gttgatgaag attttagatc aataatgact   4140

gatatcaaga aagacaatag agtcacaaca ttaactactc atgctggaat aagaaattct   4200

ctactaacaa tacttgatca gcttcaaaga tgtcagaaat cattaaatga atttttggag   4260

gaaaaacgct cagcattccc aagattttat tttattggtg atgatgactt attagaaata   4320

ttgggccagt ctaccaaccc atcagtgatt cagtctcacc tgaagaagct ttttgctggt   4380

attaacagtg tttgctttga tgagaaatca aaacatataa ctgcaatgaa atctttagag   4440

ggagaagttg taccttttaa aaataaagtt cctctatcaa ataatgtaga gacatggttg   4500

aatgatttgg ccttagaaat gaagaaaact ttggaacagt tgttgaagga atgtgttact   4560

actgggcgaa gttctcaagg tgcagttgac ccatctctgt tcccttcaca gattttatgc   4620

ttggcggagc agattaaatt cactgaagat gtagaaaatg ctattaaaga tcatagtctt   4680

catcagattg aaacacaact ggtgaataag ttagagcaat atactaacat tgatacaagt   4740

tctgaggatc cagggaatac tgaatcgggc atcctggagc ttaaacttaa agccctaatt   4800

cttgacatta tccataatat tgatgtggta aagcagttaa accaaattca ggttcataca   4860

actgaagact gggcttggaa aaaacaactt agattctata tgaaaagtga tcatacatgt   4920

tgtgttcaaa tggtggattc tgaatttcag tatacttatg aatatcaggg taatgcttcc   4980

aaactggttt atactccact gacagacaag tgctacttaa ctctcactca agccatgaag   5040

atgggacttg gaggaaatcc ttatggacca gctggaactg ggaaaacgga atcagtaaag   5100

gctttaggtg gacttcttgg aagacaagtt ttagtcttta attgtgatga gggcatcgat   5160

gtgaagtcaa tgggacgaat atttgttggt ttggtgaagt gtggggcctg gggttgtttt   5220

gatgaattta ataggctgga agaatctgta ctgtcagcag tttctatgca aatccagaca   5280

attcaagatg ctttgaagaa tcatagaact gtatgtgaac tgcttggcaa ggaggtagaa   5340

gtaaattcta attctggaat ttttatcact atgaatcctg ctggaaaagg ttatggagga   5400

agacaaaaac tgcctgataa tcttaaacag cttttcaggc ccgtagctat gtctcatcca   5460

gacaatgagc ttattgcaga agttattctc tattcggaag gctttaaaga cgctaaagta   5520

ttgagcagaa aattggtagc tattttcaat ctatctaggg aacttttgac acctcagcaa   5580

cattatgatt ggggtttgag agctttgaag acagttctga gaggaagtgg aaatctcctt   5640

agacagctaa acaaaagtgg cactacacag aatgctaatg aaagtcatat tgtggtacaa   5700

gcactgaggc ttaataccat gtcaaagttt acgtttactg attgcacccg gtttgatgca   5760

ctgataaaag atgtctttcc gggaattgaa ttgaaagaag tggaatatga tgaactaagt   5820

gctgcattaa agcaggtctt tgaagaggcc aattatgaaa ttatacccaa tcagatcaaa   5880

aaggctttag aattgtatga acagttatgc cagaggatgg gagttgttat tgttggtcca   5940

agtggtgctg gaaaatcaac gctttggaga atgttaaggg ctgcgctttg taaaactggc   6000

aaagtagtga aacaatatac tatgaatccc aaagctatgc ctcgatatca attattaggc   6060

catattgaca tggacacaag agaatggtct gatggtgttt tgacaaatag tgctcgtcaa   6120

gtggttcggg aacctcaaga tgtcagctca tggataatct gtgatggtga tattgaccct   6180

gaatggatag aatctctgaa ttctgttctg gatgataatc gactgctgac tatgcccagt   6240

ggagaaagga ttcagtttgg cccaaatgtt aactttgtat ttgaaactca tgatttaagt   6300

tgtgcatcac cagccacaat atctagaatg ggaatgatct ttcttagtga tgaagagaca   6360

gatcttaatt ctctgataaa atcttggttg aggaatcagc ctgctgaata tagaaataat   6420

cttgaaaatt ggattggaga ttattttgaa aaggctttac aatgggttct aaagcagaat   6480

gactatgtgg tagaaacaag tttggttggg actgtgatga atggtttgtc acatctacat   6540

ggttgcagag atcatgacga attcattatt aatctcataa ggggacttgg tggaaatctg   6600

aatatgaagt cacgtttgga atttaccaaa gaggtttttc attgggcacg agaatctcct   6660

ccagactttc acaaacctat ggatacctac tatgactcta ctaggggtcg attagcaaca   6720

tatgtgctta agaagccaga agacttgact gctgatgatt tcagtaacgg cttaactctt   6780

ccagtcattc agactcctga catgcaacga ggtctagatt atttcaaacc atggttaagt   6840

tctgatacta aacagccctt tattctggta ggaccagaag gatgtggcaa agggatgctg   6900

ctcaggtacg cattttcaca actccggtcc actcaaattg ctacagttca ctgtagtgca   6960

caaaccactt ctcgacatct cctgcagaaa ctgagccaga cttgcatggt aatcagtact   7020

aatactggtc gtgtatacag accaaaagac tgtgaaagac ttgttctgta cttaaaagat   7080

atcaacctac ctaaacttga taaatggggg accagtactt tggtagcatt cctacaacag   7140

gtattgacgt atcaaggatt ttatgatgaa aatttggaat gggttggtct agaaaatatt   7200

caaattgtgg cttctatgtc agctggagga agactgggaa gacataaact tactaccaga   7260

tttacttcca tcgttcgtct ttgttctata gattacccag aaagagagca gttacaaacg   7320

atttatggag catatttgga accagttcta cataaaaatc tgaagaatca ttctatttgg   7380

ggttcttcat caaaaattta tcttttagca ggatctatgg tacaagtgta tgaacaggtg   7440

cgagccaaat ttacagttga tgattatagt cactatttct ttactccttg cattcttacc   7500

caatgggttc ttggcttatt tagatatgat ttagaaggag gatcctcaaa ccatccacta   7560

gattatgtgt tagaaattgt agcatatgag gcacggcgct tatttcgtga caaaattgtt   7620

ggtgcaaagg aacttcattt atttgacatc attttaacat cagtgtttca aggagattgg   7680

ggctcagaca tattagacaa tatgtcagat agtttctacg ttacatgggg agctcggcat   7740

aattcaggag caagggcagc cccaggacaa ccattacctc cacatggaaa accacttgga   7800

aaactaaact ctactgatct caaggatgtt attaaaaagg gtcttattca ttatggacga   7860

gataaccaga atttagacat tttacttttc cacgaagtct tggagtatat gtctaggata   7920

gatagagtgc tgagtttccc tggaggttca cttctattag caggacgcag tggtgtaggt   7980

cgtcggacca tcacttcttt agtcagtcac atgcatggag cggtcctgtt ttctccaaag   8040

atttccagag gatatgaact gaagcagttc aaaaatgatc tcaaacatgt gctgcaactt   8100

gcaggaattg aagcacaaca ggtagtttta cttcttgagg attaccagtt tgtacatcct   8160

acatttttgg agatgatcaa tagccttttg tc                                 8192


<210>  1720
<211>  4307
<212>  PRT
<213>  Homosapiens

<400>  1720

Met Ala Asn Gly Thr Ala Asp Val Arg Lys Leu Phe Ile Phe Thr Thr 
1               5                   10                  15      


Thr Gln Asn Tyr Phe Gly Leu Met Ser Glu Leu Trp Asp Gln Pro Leu 
            20                  25                  30          


Leu Cys Asn Cys Leu Glu Ile Asn Asn Phe Leu Asp Asp Gly Asn Gln 
        35                  40                  45              


Met Leu Leu Arg Val Gln Arg Ser Asp Ala Gly Ile Ser Phe Ser Asn 
    50                  55                  60                  


Thr Ile Glu Phe Gly Asp Thr Lys Asp Lys Val Leu Val Phe Phe Lys 
65                  70                  75                  80  


Leu Arg Pro Glu Val Ile Thr Asp Glu Asn Leu His Asp Asn Ile Leu 
                85                  90                  95      


Val Ser Ser Met Leu Glu Ser Pro Ile Ser Ser Leu Tyr Gln Ala Val 
            100                 105                 110         


Arg Gln Val Phe Ala Pro Met Leu Leu Lys Asp Gln Glu Trp Ser Arg 
        115                 120                 125             


Asn Phe Asp Pro Lys Leu Gln Asn Leu Leu Ser Glu Leu Glu Ala Gly 
    130                 135                 140                 


Leu Gly Ile Val Leu Arg Arg Ser Asp Thr Asn Leu Thr Lys Leu Lys 
145                 150                 155                 160 


Phe Lys Glu Asp Asp Thr Arg Gly Ile Leu Thr Pro Ser Asp Glu Phe 
                165                 170                 175     


Gln Phe Trp Ile Glu Gln Ala His Arg Gly Asn Lys Gln Ile Ser Lys 
            180                 185                 190         


Glu Arg Ala Asn Tyr Phe Lys Glu Leu Phe Glu Thr Ile Ala Arg Glu 
        195                 200                 205             


Phe Tyr Asn Leu Asp Ser Leu Ser Leu Leu Glu Val Val Asp Leu Val 
    210                 215                 220                 


Glu Thr Thr Gln Asp Val Val Asp Asp Val Trp Arg Gln Thr Glu His 
225                 230                 235                 240 


Asp His Tyr Pro Glu Ser Arg Met Leu His Leu Leu Asp Ile Ile Gly 
                245                 250                 255     


Gly Ser Phe Gly Arg Phe Val Gln Lys Lys Leu Gly Thr Leu Asn Leu 
            260                 265                 270         


Trp Glu Asp Pro Tyr Tyr Leu Val Lys Glu Ser Leu Lys Ala Gly Ile 
        275                 280                 285             


Ser Ile Cys Glu Gln Trp Val Ile Val Cys Asn His Leu Thr Gly Gln 
    290                 295                 300                 


Val Trp Gln Arg Tyr Val Pro His Pro Trp Lys Asn Glu Lys Tyr Phe 
305                 310                 315                 320 


Pro Glu Thr Leu Asp Lys Leu Gly Lys Arg Leu Glu Glu Val Leu Ala 
                325                 330                 335     


Ile Arg Thr Ile His Glu Lys Phe Leu Tyr Phe Leu Pro Ala Ser Glu 
            340                 345                 350         


Glu Lys Ile Ile Cys Leu Thr Arg Val Phe Glu Pro Phe Thr Gly Leu 
        355                 360                 365             


Asn Pro Val Gln Tyr Asn Pro Tyr Thr Glu Pro Leu Trp Lys Ala Ala 
    370                 375                 380                 


Val Ser Gln Tyr Glu Lys Ile Ile Ala Pro Ala Glu Gln Lys Ile Ala 
385                 390                 395                 400 


Gly Lys Leu Lys Asn Tyr Ile Ser Glu Ile Gln Asp Ser Pro Gln Gln 
                405                 410                 415     


Leu Leu Gln Ala Phe Leu Lys Tyr Lys Glu Leu Val Lys Arg Pro Thr 
            420                 425                 430         


Ile Ser Lys Glu Leu Met Leu Glu Arg Glu Thr Leu Leu Ala Arg Leu 
        435                 440                 445             


Val Asp Ser Ile Lys Asp Phe Arg Leu Asp Phe Glu Asn Arg Cys Arg 
    450                 455                 460                 


Gly Ile Pro Gly Asp Ala Ser Gly Pro Leu Ser Gly Lys Asn Leu Ser 
465                 470                 475                 480 


Glu Val Val Asn Ser Ile Val Trp Val Arg Gln Leu Glu Leu Lys Val 
                485                 490                 495     


Asp Asp Thr Ile Lys Ile Ala Glu Ala Leu Leu Ser Asp Leu Pro Gly 
            500                 505                 510         


Phe Arg Cys Phe His Gln Ser Ala Lys Asp Leu Leu Asp Gln Leu Lys 
        515                 520                 525             


Leu Tyr Glu Gln Glu Gln Phe Asp Asp Trp Ser Arg Asp Ile Gln Ser 
    530                 535                 540                 


Gly Leu Ser Asp Ser Arg Ser Gly Leu Cys Ile Glu Ala Ser Ser Arg 
545                 550                 555                 560 


Ile Met Glu Leu Asp Ser Asn Asp Gly Leu Leu Lys Val His Tyr Ser 
                565                 570                 575     


Asp Arg Leu Val Ile Leu Leu Arg Glu Val Arg Gln Leu Ser Ala Leu 
            580                 585                 590         


Gly Phe Val Ile Pro Ala Lys Ile Gln Gln Val Ala Asn Ile Ala Gln 
        595                 600                 605             


Lys Phe Cys Lys Gln Ala Ile Ile Leu Lys Gln Val Ala His Phe Tyr 
    610                 615                 620                 


Asn Ser Ile Asp Gln Gln Met Ile Gln Ser Gln Arg Pro Met Met Leu 
625                 630                 635                 640 


Gln Ser Ala Leu Ala Phe Glu Gln Ile Ile Lys Asn Ser Lys Ala Gly 
                645                 650                 655     


Ser Gly Gly Lys Ser Gln Ile Thr Trp Asp Asn Pro Lys Glu Leu Glu 
            660                 665                 670         


Gly Tyr Ile Gln Lys Leu Gln Asn Ala Ala Glu Arg Leu Ala Thr Glu 
        675                 680                 685             


Asn Arg Lys Leu Arg Lys Trp His Thr Thr Phe Cys Glu Lys Val Val 
    690                 695                 700                 


Val Leu Met Asn Ile Asp Leu Leu Arg Gln Gln Gln Arg Trp Lys Asp 
705                 710                 715                 720 


Gly Leu Gln Glu Leu Arg Thr Gly Leu Ala Thr Val Glu Ala Gln Gly 
                725                 730                 735     


Phe Gln Ala Ser Asp Met His Ala Trp Lys Gln His Trp Asn His Gln 
            740                 745                 750         


Leu Tyr Lys Ala Leu Glu His Gln Tyr Gln Met Gly Leu Glu Ala Leu 
        755                 760                 765             


Asn Glu Asn Leu Pro Glu Ile Asn Ile Asp Leu Thr Tyr Lys Gln Gly 
    770                 775                 780                 


Arg Leu Gln Phe Arg Pro Pro Phe Glu Glu Ile Arg Ala Lys Tyr Tyr 
785                 790                 795                 800 


Arg Glu Met Lys Arg Phe Ile Gly Ile Pro Asn Gln Phe Lys Gly Val 
                805                 810                 815     


Gly Glu Ala Gly Asp Glu Ser Ile Phe Ser Ile Met Ile Asp Arg Asn 
            820                 825                 830         


Ala Ser Gly Phe Leu Thr Ile Phe Ser Lys Ala Glu Asp Leu Phe Arg 
        835                 840                 845             


Arg Leu Ser Ala Val Leu His Gln His Lys Glu Trp Ile Val Ile Gly 
    850                 855                 860                 


Gln Val Asp Met Glu Ala Leu Val Glu Lys His Leu Phe Thr Val His 
865                 870                 875                 880 


Asp Trp Glu Lys Asn Phe Lys Ala Leu Lys Ile Lys Gly Lys Glu Val 
                885                 890                 895     


Glu Arg Leu Pro Ser Ala Val Lys Val Asp Cys Leu Asn Ile Asn Cys 
            900                 905                 910         


Asn Pro Val Lys Thr Val Ile Asp Asp Leu Ile Gln Lys Leu Phe Asp 
        915                 920                 925             


Leu Leu Val Leu Ser Leu Lys Lys Ser Ile Gln Ala His Leu His Glu 
    930                 935                 940                 


Ile Asp Thr Phe Val Thr Glu Ala Met Glu Val Leu Thr Ile Met Pro 
945                 950                 955                 960 


Gln Ser Val Glu Glu Ile Gly Asp Ala Asn Leu Gln Tyr Ser Lys Leu 
                965                 970                 975     


Gln Glu Arg Lys Pro Glu Ile Leu Pro Leu Phe Gln Glu Ala Glu Asp 
            980                 985                 990         


Lys Asn Arg Leu Leu Arg Thr Val  Ala Gly Gly Gly Leu  Glu Thr Ile 
        995                 1000                 1005             


Ser Asn  Leu Lys Ala Lys Trp  Asp Lys Phe Glu Leu  Met Met Glu 
    1010                 1015                 1020             


Ser His  Gln Leu Met Ile Lys  Asp Gln Ile Glu Val  Met Lys Gly 
    1025                 1030                 1035             


Asn Val  Lys Ser Arg Leu Gln  Ile Tyr Tyr Gln Glu  Leu Glu Lys 
    1040                 1045                 1050             


Phe Lys  Ala Arg Trp Asp Gln  Leu Lys Pro Gly Asp  Asp Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Gln His Asn Thr  Leu Asp Lys Ser Ala  Lys Leu Ile 
    1070                 1075                 1080             


Lys Glu  Lys Lys Ile Glu Phe  Asp Asp Leu Glu Val  Thr Arg Lys 
    1085                 1090                 1095             


Lys Leu  Val Asp Asp Cys His  His Phe Arg Leu Glu  Glu Pro Asn 
    1100                 1105                 1110             


Phe Ser  Leu Ala Ser Ser Ile  Ser Lys Asp Ile Glu  Ser Cys Ala 
    1115                 1120                 1125             


Gln Ile  Trp Ala Phe Tyr Glu  Glu Phe Gln Gln Gly  Phe Gln Glu 
    1130                 1135                 1140             


Met Ala  Asn Glu Asp Trp Ile  Thr Phe Arg Thr Lys  Thr Tyr Leu 
    1145                 1150                 1155             


Phe Glu  Glu Phe Leu Met Asn  Trp His Asp Arg Leu  Arg Lys Val 
    1160                 1165                 1170             


Glu Glu  His Ser Val Met Thr  Val Lys Leu Gln Ser  Glu Val Asp 
    1175                 1180                 1185             


Lys Tyr  Lys Ile Val Ile Pro  Ile Leu Lys Tyr Val  Arg Gly Glu 
    1190                 1195                 1200             


His Leu  Ser Pro Asp His Trp  Leu Asp Leu Phe Arg  Leu Leu Gly 
    1205                 1210                 1215             


Leu Pro  Arg Gly Thr Ser Leu  Glu Lys Leu Leu Phe  Gly Asp Leu 
    1220                 1225                 1230             


Leu Arg  Val Ala Asp Thr Ile  Val Ala Lys Ala Ala  Asp Leu Lys 
    1235                 1240                 1245             


Asp Leu  Asn Ser Arg Ala Gln  Gly Glu Val Thr Ile  Arg Glu Ala 
    1250                 1255                 1260             


Leu Arg  Glu Leu Asp Leu Trp  Gly Val Gly Ala Val  Phe Thr Leu 
    1265                 1270                 1275             


Ile Asp  Tyr Glu Asp Ser Gln  Ser Arg Thr Met Lys  Leu Ile Lys 
    1280                 1285                 1290             


Asp Trp  Lys Asp Ile Val Asn  Gln Val Gly Asp Asn  Arg Cys Leu 
    1295                 1300                 1305             


Leu Gln  Ser Leu Lys Asp Ser  Pro Tyr Tyr Lys Gly  Phe Glu Asp 
    1310                 1315                 1320             


Lys Val  Ser Ile Trp Glu Arg  Lys Leu Ala Glu Leu  Asp Glu Tyr 
    1325                 1330                 1335             


Leu Gln  Asn Leu Asn His Ile  Gln Arg Lys Trp Val  Tyr Leu Glu 
    1340                 1345                 1350             


Pro Ile  Phe Gly Arg Gly Ala  Leu Pro Lys Glu Gln  Thr Arg Phe 
    1355                 1360                 1365             


Asn Arg  Val Asp Glu Asp Phe  Arg Ser Ile Met Thr  Asp Ile Lys 
    1370                 1375                 1380             


Lys Asp  Asn Arg Val Thr Thr  Leu Thr Thr His Ala  Gly Ile Arg 
    1385                 1390                 1395             


Asn Ser  Leu Leu Thr Ile Leu  Asp Gln Leu Gln Arg  Cys Gln Lys 
    1400                 1405                 1410             


Ser Leu  Asn Glu Phe Leu Glu  Glu Lys Arg Ser Ala  Phe Pro Arg 
    1415                 1420                 1425             


Phe Tyr  Phe Ile Gly Asp Asp  Asp Leu Leu Glu Ile  Leu Gly Gln 
    1430                 1435                 1440             


Ser Thr  Asn Pro Ser Val Ile  Gln Ser His Leu Lys  Lys Leu Phe 
    1445                 1450                 1455             


Ala Gly  Ile Asn Ser Val Cys  Phe Asp Glu Lys Ser  Lys His Ile 
    1460                 1465                 1470             


Thr Ala  Met Lys Ser Leu Glu  Gly Glu Val Val Pro  Phe Lys Asn 
    1475                 1480                 1485             


Lys Val  Pro Leu Ser Asn Asn  Val Glu Thr Trp Leu  Asn Asp Leu 
    1490                 1495                 1500             


Ala Leu  Glu Met Lys Lys Thr  Leu Glu Gln Leu Leu  Lys Glu Cys 
    1505                 1510                 1515             


Val Thr  Thr Gly Arg Ser Ser  Gln Gly Ala Val Asp  Pro Ser Leu 
    1520                 1525                 1530             


Phe Pro  Ser Gln Ile Leu Cys  Leu Ala Glu Gln Ile  Lys Phe Thr 
    1535                 1540                 1545             


Glu Asp  Val Glu Asn Ala Ile  Lys Asp His Ser Leu  His Gln Ile 
    1550                 1555                 1560             


Glu Thr  Gln Leu Val Asn Lys  Leu Glu Gln Tyr Thr  Asn Ile Asp 
    1565                 1570                 1575             


Thr Ser  Ser Glu Asp Pro Gly  Asn Thr Glu Ser Gly  Ile Leu Glu 
    1580                 1585                 1590             


Leu Lys  Leu Lys Ala Leu Ile  Leu Asp Ile Ile His  Asn Ile Asp 
    1595                 1600                 1605             


Val Val  Lys Gln Leu Asn Gln  Ile Gln Val His Thr  Thr Glu Asp 
    1610                 1615                 1620             


Trp Ala  Trp Lys Lys Gln Leu  Arg Phe Tyr Met Lys  Ser Asp His 
    1625                 1630                 1635             


Thr Cys  Cys Val Gln Met Val  Asp Ser Glu Phe Gln  Tyr Thr Tyr 
    1640                 1645                 1650             


Glu Tyr  Gln Gly Asn Ala Ser  Lys Leu Val Tyr Thr  Pro Leu Thr 
    1655                 1660                 1665             


Asp Lys  Cys Tyr Leu Thr Leu  Thr Gln Ala Met Lys  Met Gly Leu 
    1670                 1675                 1680             


Gly Gly  Asn Pro Tyr Gly Pro  Ala Gly Thr Gly Lys  Thr Glu Ser 
    1685                 1690                 1695             


Val Lys  Ala Leu Gly Gly Leu  Leu Gly Arg Gln Val  Leu Val Phe 
    1700                 1705                 1710             


Asn Cys  Asp Glu Gly Ile Asp  Val Lys Ser Met Gly  Arg Ile Phe 
    1715                 1720                 1725             


Val Gly  Leu Val Lys Cys Gly  Ala Trp Gly Cys Phe  Asp Glu Phe 
    1730                 1735                 1740             


Asn Arg  Leu Glu Glu Ser Val  Leu Ser Ala Val Ser  Met Gln Ile 
    1745                 1750                 1755             


Gln Thr  Ile Gln Asp Ala Leu  Lys Asn His Arg Thr  Val Cys Glu 
    1760                 1765                 1770             


Leu Leu  Gly Lys Glu Val Glu  Val Asn Ser Asn Ser  Gly Ile Phe 
    1775                 1780                 1785             


Ile Thr  Met Asn Pro Ala Gly  Lys Gly Tyr Gly Gly  Arg Gln Lys 
    1790                 1795                 1800             


Leu Pro  Asp Asn Leu Lys Gln  Leu Phe Arg Pro Val  Ala Met Ser 
    1805                 1810                 1815             


His Pro  Asp Asn Glu Leu Ile  Ala Glu Val Ile Leu  Tyr Ser Glu 
    1820                 1825                 1830             


Gly Phe  Lys Asp Ala Lys Val  Leu Ser Arg Lys Leu  Val Ala Ile 
    1835                 1840                 1845             


Phe Asn  Leu Ser Arg Glu Leu  Leu Thr Pro Gln Gln  His Tyr Asp 
    1850                 1855                 1860             


Trp Gly  Leu Arg Ala Leu Lys  Thr Val Leu Arg Gly  Ser Gly Asn 
    1865                 1870                 1875             


Leu Leu  Arg Gln Leu Asn Lys  Ser Gly Thr Thr Gln  Asn Ala Asn 
    1880                 1885                 1890             


Glu Ser  His Ile Val Val Gln  Ala Leu Arg Leu Asn  Thr Met Ser 
    1895                 1900                 1905             


Lys Phe  Thr Phe Thr Asp Cys  Thr Arg Phe Asp Ala  Leu Ile Lys 
    1910                 1915                 1920             


Asp Val  Phe Pro Gly Ile Glu  Leu Lys Glu Val Glu  Tyr Asp Glu 
    1925                 1930                 1935             


Leu Ser  Ala Ala Leu Lys Gln  Val Phe Glu Glu Ala  Asn Tyr Glu 
    1940                 1945                 1950             


Ile Ile  Pro Asn Gln Ile Lys  Lys Ala Leu Glu Leu  Tyr Glu Gln 
    1955                 1960                 1965             


Leu Cys  Gln Arg Met Gly Val  Val Ile Val Gly Pro  Ser Gly Ala 
    1970                 1975                 1980             


Gly Lys  Ser Thr Leu Trp Arg  Met Leu Arg Ala Ala  Leu Cys Lys 
    1985                 1990                 1995             


Thr Gly  Lys Val Val Lys Gln  Tyr Thr Met Asn Pro  Lys Ala Met 
    2000                 2005                 2010             


Pro Arg  Tyr Gln Leu Leu Gly  His Ile Asp Met Asp  Thr Arg Glu 
    2015                 2020                 2025             


Trp Ser  Asp Gly Val Leu Thr  Asn Ser Ala Arg Gln  Val Val Arg 
    2030                 2035                 2040             


Glu Pro  Gln Asp Val Ser Ser  Trp Ile Ile Cys Asp  Gly Asp Ile 
    2045                 2050                 2055             


Asp Pro  Glu Trp Ile Glu Ser  Leu Asn Ser Val Leu  Asp Asp Asn 
    2060                 2065                 2070             


Arg Leu  Leu Thr Met Pro Ser  Gly Glu Arg Ile Gln  Phe Gly Pro 
    2075                 2080                 2085             


Asn Val  Asn Phe Val Phe Glu  Thr His Asp Leu Ser  Cys Ala Ser 
    2090                 2095                 2100             


Pro Ala  Thr Ile Ser Arg Met  Gly Met Ile Phe Leu  Ser Asp Glu 
    2105                 2110                 2115             


Glu Thr  Asp Leu Asn Ser Leu  Ile Lys Ser Trp Leu  Arg Asn Gln 
    2120                 2125                 2130             


Pro Ala  Glu Tyr Arg Asn Asn  Leu Glu Asn Trp Ile  Gly Asp Tyr 
    2135                 2140                 2145             


Phe Glu  Lys Ala Leu Gln Trp  Val Leu Lys Gln Asn  Asp Tyr Val 
    2150                 2155                 2160             


Val Glu  Thr Ser Leu Val Gly  Thr Val Met Asn Gly  Leu Ser His 
    2165                 2170                 2175             


Leu His  Gly Cys Arg Asp His  Asp Glu Phe Ile Ile  Asn Leu Ile 
    2180                 2185                 2190             


Arg Gly  Leu Gly Gly Asn Leu  Asn Met Lys Ser Arg  Leu Glu Phe 
    2195                 2200                 2205             


Thr Lys  Glu Val Phe His Trp  Ala Arg Glu Ser Pro  Pro Asp Phe 
    2210                 2215                 2220             


His Lys  Pro Met Asp Thr Tyr  Tyr Asp Ser Thr Arg  Gly Arg Leu 
    2225                 2230                 2235             


Ala Thr  Tyr Val Leu Lys Lys  Pro Glu Asp Leu Thr  Ala Asp Asp 
    2240                 2245                 2250             


Phe Ser  Asn Gly Leu Thr Leu  Pro Val Ile Gln Thr  Pro Asp Met 
    2255                 2260                 2265             


Gln Arg  Gly Leu Asp Tyr Phe  Lys Pro Trp Leu Ser  Ser Asp Thr 
    2270                 2275                 2280             


Lys Gln  Pro Phe Ile Leu Val  Gly Pro Glu Gly Cys  Gly Lys Gly 
    2285                 2290                 2295             


Met Leu  Leu Arg Tyr Ala Phe  Ser Gln Leu Arg Ser  Thr Gln Ile 
    2300                 2305                 2310             


Ala Thr  Val His Cys Ser Ala  Gln Thr Thr Ser Arg  His Leu Leu 
    2315                 2320                 2325             


Gln Lys  Leu Ser Gln Thr Cys  Met Val Ile Ser Thr  Asn Thr Gly 
    2330                 2335                 2340             


Arg Val  Tyr Arg Pro Lys Asp  Cys Glu Arg Leu Val  Leu Tyr Leu 
    2345                 2350                 2355             


Lys Asp  Ile Asn Leu Pro Lys  Leu Asp Lys Trp Gly  Thr Ser Thr 
    2360                 2365                 2370             


Leu Val  Ala Phe Leu Gln Gln  Val Leu Thr Tyr Gln  Gly Phe Tyr 
    2375                 2380                 2385             


Asp Glu  Asn Leu Glu Trp Val  Gly Leu Glu Asn Ile  Gln Ile Val 
    2390                 2395                 2400             


Ala Ser  Met Ser Ala Gly Gly  Arg Leu Gly Arg His  Lys Leu Thr 
    2405                 2410                 2415             


Thr Arg  Phe Thr Ser Ile Val  Arg Leu Cys Ser Ile  Asp Tyr Pro 
    2420                 2425                 2430             


Glu Arg  Glu Gln Leu Gln Thr  Ile Tyr Gly Ala Tyr  Leu Glu Pro 
    2435                 2440                 2445             


Val Leu  His Lys Asn Leu Lys  Asn His Ser Ile Trp  Gly Ser Ser 
    2450                 2455                 2460             


Ser Lys  Ile Tyr Leu Leu Ala  Gly Ser Met Val Gln  Val Tyr Glu 
    2465                 2470                 2475             


Gln Val  Arg Ala Lys Phe Thr  Val Asp Asp Tyr Ser  His Tyr Phe 
    2480                 2485                 2490             


Phe Thr  Pro Cys Ile Leu Thr  Gln Trp Val Leu Gly  Leu Phe Arg 
    2495                 2500                 2505             


Tyr Asp  Leu Glu Gly Gly Ser  Ser Asn His Pro Leu  Asp Tyr Val 
    2510                 2515                 2520             


Leu Glu  Ile Val Ala Tyr Glu  Ala Arg Arg Leu Phe  Arg Asp Lys 
    2525                 2530                 2535             


Ile Val  Gly Ala Lys Glu Leu  His Leu Phe Asp Ile  Ile Leu Thr 
    2540                 2545                 2550             


Ser Val  Phe Gln Gly Asp Trp  Gly Ser Asp Ile Leu  Asp Asn Met 
    2555                 2560                 2565             


Ser Asp  Ser Phe Tyr Val Thr  Trp Gly Ala Arg His  Asn Ser Gly 
    2570                 2575                 2580             


Ala Arg  Ala Ala Pro Gly Gln  Pro Leu Pro Pro His  Gly Lys Pro 
    2585                 2590                 2595             


Leu Gly  Lys Leu Asn Ser Thr  Asp Leu Lys Asp Val  Ile Lys Lys 
    2600                 2605                 2610             


Gly Leu  Ile His Tyr Gly Arg  Asp Asn Gln Asn Leu  Asp Ile Leu 
    2615                 2620                 2625             


Leu Phe  His Glu Val Leu Glu  Tyr Met Ser Arg Ile  Asp Arg Val 
    2630                 2635                 2640             


Leu Ser  Phe Pro Gly Gly Ser  Leu Leu Leu Ala Gly  Arg Ser Gly 
    2645                 2650                 2655             


Val Gly  Arg Arg Thr Ile Thr  Ser Leu Val Ser His  Met His Gly 
    2660                 2665                 2670             


Ala Val  Leu Phe Ser Pro Lys  Ile Ser Arg Gly Tyr  Glu Leu Lys 
    2675                 2680                 2685             


Gln Phe  Lys Asn Asp Leu Lys  His Val Leu Gln Leu  Ala Gly Ile 
    2690                 2695                 2700             


Glu Ala  Gln Gln Val Val Leu  Leu Leu Glu Asp Tyr  Gln Phe Val 
    2705                 2710                 2715             


His Pro  Thr Phe Leu Glu Met  Ile Asn Ser Leu Leu  Ser Ser Gly 
    2720                 2725                 2730             


Glu Val  Pro Gly Leu Tyr Thr  Leu Glu Glu Leu Glu  Pro Leu Leu 
    2735                 2740                 2745             


Leu Pro  Leu Lys Asp Gln Ala  Ser Gln Asp Gly Phe  Phe Gly Pro 
    2750                 2755                 2760             


Val Phe  Asn Tyr Phe Thr Tyr  Arg Ile Gln Gln Asn  Leu His Ile 
    2765                 2770                 2775             


Val Leu  Ile Met Asp Ser Ala  Asn Ser Asn Phe Met  Ile Asn Cys 
    2780                 2785                 2790             


Glu Ser  Asn Pro Ala Leu His  Lys Lys Cys Gln Val  Leu Trp Met 
    2795                 2800                 2805             


Glu Gly  Trp Ser Asn Ser Ser  Met Lys Lys Ile Pro  Glu Met Leu 
    2810                 2815                 2820             


Phe Ser  Glu Thr Gly Gly Gly  Glu Lys Tyr Asn Asp  Lys Lys Arg 
    2825                 2830                 2835             


Lys Glu  Glu Lys Lys Lys Asn  Ser Val Asp Pro Asp  Phe Leu Lys 
    2840                 2845                 2850             


Ser Phe  Leu Leu Ile His Glu  Ser Cys Lys Ala Tyr  Gly Ala Thr 
    2855                 2860                 2865             


Pro Ser  Arg Tyr Met Thr Phe  Leu His Val Tyr Ser  Ala Ile Ser 
    2870                 2875                 2880             


Ser Ser  Lys Lys Lys Glu Leu  Leu Lys Arg Gln Ser  His Leu Gln 
    2885                 2890                 2895             


Ala Gly  Val Ser Lys Leu Asn  Glu Ala Lys Ala Leu  Val Asp Glu 
    2900                 2905                 2910             


Leu Asn  Arg Lys Ala Gly Glu  Gln Ser Val Leu Leu  Lys Thr Lys 
    2915                 2920                 2925             


Gln Asp  Glu Ala Asp Ala Ala  Leu Gln Met Ile Thr  Val Ser Met 
    2930                 2935                 2940             


Gln Asp  Ala Ser Glu Gln Lys  Thr Glu Leu Glu Arg  Leu Lys His 
    2945                 2950                 2955             


Arg Ile  Ala Glu Glu Val Val  Lys Ile Glu Glu Arg  Lys Asn Lys 
    2960                 2965                 2970             


Ile Asp  Asp Glu Leu Lys Glu  Val Gln Pro Leu Val  Asn Glu Ala 
    2975                 2980                 2985             


Lys Leu  Ala Val Gly Asn Ile  Lys Pro Glu Ser Leu  Ser Glu Ile 
    2990                 2995                 3000             


Arg Ser  Leu Arg Met Pro Pro  Asp Val Ile Arg Asp  Ile Leu Glu 
    3005                 3010                 3015             


Gly Val  Leu Arg Leu Met Gly  Ile Phe Asp Thr Ser  Trp Val Ser 
    3020                 3025                 3030             


Met Lys  Ser Phe Leu Ala Lys  Arg Gly Val Arg Glu  Asp Ile Ala 
    3035                 3040                 3045             


Thr Phe  Asp Ala Arg Asn Ile  Ser Lys Glu Ile Arg  Glu Ser Val 
    3050                 3055                 3060             


Glu Glu  Leu Leu Phe Lys Asn  Lys Gly Ser Phe Asp  Pro Lys Asn 
    3065                 3070                 3075             


Ala Lys  Arg Ala Ser Thr Ala  Ala Ala Pro Leu Ala  Ala Trp Val 
    3080                 3085                 3090             


Lys Ala  Asn Ile Gln Tyr Ser  His Val Leu Glu Arg  Ile His Pro 
    3095                 3100                 3105             


Leu Glu  Thr Glu Gln Ala Gly  Leu Glu Ser Asn Leu  Lys Lys Thr 
    3110                 3115                 3120             


Glu Asp  Arg Lys Arg Lys Leu  Glu Glu Leu Leu Asn  Ser Val Gly 
    3125                 3130                 3135             


Gln Lys  Val Ser Glu Leu Lys  Glu Lys Phe Gln Ser  Arg Thr Ser 
    3140                 3145                 3150             


Glu Ala  Ala Lys Leu Glu Ala  Glu Val Ser Lys Ala  Gln Glu Thr 
    3155                 3160                 3165             


Ile Lys  Ala Ala Glu Val Leu  Ile Asn Gln Leu Asp  Arg Glu His 
    3170                 3175                 3180             


Lys Arg  Trp Asn Ala Gln Val  Val Glu Ile Thr Glu  Glu Leu Ala 
    3185                 3190                 3195             


Thr Leu  Pro Lys Arg Ala Gln  Leu Ala Ala Ala Phe  Ile Thr Tyr 
    3200                 3205                 3210             


Leu Ser  Ala Ala Pro Glu Ser  Leu Arg Lys Thr Cys  Leu Glu Glu 
    3215                 3220                 3225             


Trp Thr  Lys Ser Ala Gly Leu  Glu Lys Phe Asp Leu  Arg Arg Phe 
    3230                 3235                 3240             


Leu Cys  Thr Glu Ser Glu Gln  Leu Ile Trp Lys Ser  Glu Gly Leu 
    3245                 3250                 3255             


Pro Ser  Asp Asp Leu Ser Ile  Glu Asn Ala Leu Val  Ile Leu Gln 
    3260                 3265                 3270             


Ser Arg  Val Cys Pro Phe Leu  Ile Asp Pro Ser Ser  Gln Ala Thr 
    3275                 3280                 3285             


Glu Trp  Leu Lys Thr His Leu  Lys Asp Ser Arg Leu  Glu Val Ile 
    3290                 3295                 3300             


Asn Gln  Gln Asp Ser Asn Phe  Ile Thr Ala Leu Glu  Leu Ala Val 
    3305                 3310                 3315             


Arg Phe  Gly Lys Thr Leu Ile  Ile Gln Glu Met Asp  Gly Val Glu 
    3320                 3325                 3330             


Pro Val  Leu Tyr Pro Leu Leu  Arg Arg Asp Leu Val  Ala Gln Gly 
    3335                 3340                 3345             


Pro Arg  Tyr Val Val Gln Ile  Gly Asp Lys Ile Ile  Asp Tyr Asn 
    3350                 3355                 3360             


Glu Glu  Phe Arg Leu Phe Leu  Ser Thr Arg Asn Pro  Asn Pro Phe 
    3365                 3370                 3375             


Ile Pro  Pro Asp Ala Ala Ser  Ile Val Thr Glu Val  Asn Phe Thr 
    3380                 3385                 3390             


Thr Thr  Arg Ser Gly Leu Arg  Gly Gln Leu Leu Ala  Leu Thr Ile 
    3395                 3400                 3405             


Gln His  Glu Lys Pro Asp Leu  Glu Glu Gln Lys Thr  Lys Leu Leu 
    3410                 3415                 3420             


Gln Gln  Glu Glu Asp Lys Lys  Ile Gln Leu Ala Lys  Leu Glu Glu 
    3425                 3430                 3435             


Ser Leu  Leu Glu Thr Leu Ala  Thr Ser Gln Gly Asn  Ile Leu Glu 
    3440                 3445                 3450             


Asn Lys  Asp Leu Ile Glu Ser  Leu Asn Gln Thr Lys  Ala Ser Ser 
    3455                 3460                 3465             


Ala Leu  Ile Gln Glu Ser Leu  Lys Glu Ser Tyr Lys  Leu Gln Ile 
    3470                 3475                 3480             


Ser Leu  Asp Gln Glu Arg Asp  Ala Tyr Leu Pro Leu  Ala Glu Ser 
    3485                 3490                 3495             


Ala Ser  Lys Met Tyr Phe Ile  Ile Ser Asp Leu Ser  Lys Ile Asn 
    3500                 3505                 3510             


Asn Met  Tyr Arg Phe Ser Leu  Ala Ala Phe Leu Arg  Leu Phe Gln 
    3515                 3520                 3525             


Arg Ala  Leu Gln Asn Lys Gln  Asp Ser Glu Asn Thr  Glu Gln Arg 
    3530                 3535                 3540             


Ile Gln  Ser Leu Ile Ser Ser  Leu Gln His Met Val  Tyr Glu Tyr 
    3545                 3550                 3555             


Ile Cys  Arg Cys Leu Phe Lys  Ala Asp Gln Leu Met  Phe Ala Leu 
    3560                 3565                 3570             


His Phe  Val Arg Gly Met His  Pro Glu Leu Phe Gln  Glu Asn Glu 
    3575                 3580                 3585             


Trp Asp  Thr Phe Thr Gly Val  Val Val Gly Asp Met  Leu Arg Lys 
    3590                 3595                 3600             


Ala Asp  Ser Gln Gln Lys Ile  Arg Asp Gln Leu Pro  Ser Trp Ile 
    3605                 3610                 3615             


Asp Gln  Glu Arg Ser Trp Ala  Val Ala Thr Leu Lys  Ile Ala Leu 
    3620                 3625                 3630             


Pro Ser  Leu Tyr Gln Thr Leu  Cys Phe Glu Asp Ala  Ala Leu Trp 
    3635                 3640                 3645             


Arg Thr  Tyr Tyr Asn Asn Ser  Met Cys Glu Gln Glu  Phe Pro Ser 
    3650                 3655                 3660             


Ile Leu  Ala Lys Lys Val Ser  Leu Phe Gln Gln Ile  Leu Val Val 
    3665                 3670                 3675             


Gln Ala  Leu Arg Pro Asp Arg  Leu Gln Ser Ala Met  Ala Leu Phe 
    3680                 3685                 3690             


Ala Cys  Lys Thr Leu Gly Leu  Lys Glu Val Ser Pro  Leu Pro Leu 
    3695                 3700                 3705             


Asn Leu  Lys Arg Leu Tyr Lys  Glu Thr Leu Glu Ile  Glu Pro Ile 
    3710                 3715                 3720             


Leu Ile  Ile Ile Ser Pro Gly  Ala Asp Pro Ser Gln  Glu Leu Gln 
    3725                 3730                 3735             


Glu Leu  Ala Asn Ala Glu Arg  Ser Gly Glu Cys Tyr  His Gln Val 
    3740                 3745                 3750             


Ala Met  Gly Gln Gly Gln Ala  Asp Leu Ala Ile Gln  Met Leu Lys 
    3755                 3760                 3765             


Glu Cys  Ala Arg Asn Gly Asp  Trp Leu Cys Leu Lys  Asn Leu His 
    3770                 3775                 3780             


Leu Val  Val Ser Trp Leu Pro  Val Leu Glu Lys Glu  Leu Asn Thr 
    3785                 3790                 3795             


Leu Gln  Pro Lys Asp Thr Phe  Arg Leu Trp Leu Thr  Ala Glu Val 
    3800                 3805                 3810             


His Pro  Asn Phe Thr Pro Ile  Leu Leu Gln Ser Ser  Leu Lys Ile 
    3815                 3820                 3825             


Thr Tyr  Glu Ser Pro Pro Gly  Leu Lys Lys Asn Leu  Met Arg Thr 
    3830                 3835                 3840             


Tyr Glu  Ser Trp Thr Pro Glu  Gln Ile Ser Lys Lys  Asp Asn Thr 
    3845                 3850                 3855             


His Arg  Ala His Ala Leu Phe  Ser Leu Ala Trp Phe  His Ala Ala 
    3860                 3865                 3870             


Cys Gln  Glu Arg Arg Asn Tyr  Ile Pro Gln Gly Trp  Thr Lys Phe 
    3875                 3880                 3885             


Tyr Glu  Phe Ser Leu Ser Asp  Leu Arg Ala Gly Tyr  Asn Ile Ile 
    3890                 3895                 3900             


Asp Arg  Leu Phe Asp Gly Ala  Lys Asp Val Gln Trp  Glu Phe Val 
    3905                 3910                 3915             


His Gly  Leu Leu Glu Asn Ala  Ile Tyr Gly Gly Arg  Ile Asp Asn 
    3920                 3925                 3930             


Tyr Phe  Asp Leu Arg Val Leu  Gln Ser Tyr Leu Lys  Gln Phe Phe 
    3935                 3940                 3945             


Asn Ser  Ser Val Ile Asp Val  Phe Asn Gln Arg Asn  Lys Lys Ser 
    3950                 3955                 3960             


Ile Phe  Pro Tyr Ser Val Ser  Leu Pro Gln Ser Cys  Ser Ile Leu 
    3965                 3970                 3975             


Asp Tyr  Arg Ala Val Ile Glu  Lys Ile Pro Glu Asp  Asp Lys Pro 
    3980                 3985                 3990             


Ser Phe  Phe Gly Leu Pro Ala  Asn Ile Ala Arg Ser  Ser Gln Arg 
    3995                 4000                 4005             


Met Ile  Ser Ser Gln Val Ile  Ser Gln Leu Arg Ile  Leu Gly Arg 
    4010                 4015                 4020             


Ser Ile  Thr Ala Gly Ser Lys  Phe Asp Arg Glu Ile  Trp Ser Asn 
    4025                 4030                 4035             


Glu Leu  Ser Pro Val Leu Asn  Leu Trp Lys Lys Leu  Asn Gln Asn 
    4040                 4045                 4050             


Ser Asn  Leu Ile His Gln Lys  Val Pro Pro Pro Asn  Asp Arg Gln 
    4055                 4060                 4065             


Gly Ser  Pro Ile Leu Ser Phe  Ile Ile Leu Glu Gln  Phe Asn Ala 
    4070                 4075                 4080             


Ile Arg  Leu Val Gln Ser Val  His Gln Ser Leu Ala  Ala Leu Ser 
    4085                 4090                 4095             


Lys Val  Ile Arg Gly Thr Thr  Leu Leu Ser Ser Glu  Val Gln Lys 
    4100                 4105                 4110             


Leu Ala  Ser Ala Leu Leu Asn  Gln Lys Cys Pro Leu  Ala Trp Gln 
    4115                 4120                 4125             


Ser Lys  Trp Glu Gly Pro Glu  Asp Pro Leu Gln Tyr  Leu Arg Gly 
    4130                 4135                 4140             


Leu Val  Ala Arg Ala Leu Ala  Ile Gln Asn Trp Val  Asp Lys Ala 
    4145                 4150                 4155             


Glu Lys  Gln Ala Leu Leu Ser  Glu Thr Leu Asp Leu  Ser Glu Leu 
    4160                 4165                 4170             


Phe His  Pro Asp Thr Phe Leu  Asn Ala Leu Arg Gln  Glu Thr Ala 
    4175                 4180                 4185             


Arg Ala  Val Gly Arg Ser Val  Asp Ser Leu Lys Phe  Val Ala Ser 
    4190                 4195                 4200             


Trp Lys  Gly Arg Leu Gln Glu  Ala Lys Leu Gln Ile  Lys Ile Ser 
    4205                 4210                 4215             


Gly Leu  Leu Leu Glu Gly Cys  Ser Phe Asp Gly Asn  Gln Leu Ser 
    4220                 4225                 4230             


Glu Asn  Gln Leu Asp Ser Pro  Ser Val Ser Ser Val  Leu Pro Cys 
    4235                 4240                 4245             


Phe Met  Gly Trp Ile Pro Gln  Asp Ala Cys Gly Pro  Tyr Ser Pro 
    4250                 4255                 4260             


Asp Glu  Cys Ile Ser Leu Pro  Val Tyr Thr Ser Ala  Glu Arg Asp 
    4265                 4270                 4275             


Arg Val  Val Thr Asn Ile Asp  Val Pro Cys Gly Gly  Asn Gln Asp 
    4280                 4285                 4290             


Gln Trp  Ile Gln Cys Gly Ala  Ala Leu Phe Leu Lys  Asn Gln 
    4295                 4300                 4305         


<210>  1721
<211>  6207
<212>  DNA
<213>  Homosapiens

<400>  1721
gaggcgcgtg tccgtgcact agaggccccc gtgcgtgaca caggccgatg agctcctgcg     60

ggctgcaccc acgcggagtc acagaccgaa aagcccgcgg tgtcgagcgc aggcggaggt    120

acatggcccc gacgggaggc gcgcggcgag cacccggagc tcggctccct gcctgagcac    180

ggcagccgcg cctccgcccg cgcgtcctcg cccctccggc cggcagcccg cggacatgat    240

cgtgtagcct cctcctgggc tgggatttgt ttgaagattt tcttcatgga agcgatgtcc    300

ccccagcagg agactctagg gggacagccg gggcgctcct cttccctgac aggagtgtct    360

cggctcgcgg gaggcagctg caccaagaag aaaatgaaaa cactagcaga aaggaggagg    420

agcgctccat ctcttatcct ggataaagcc ctacaaaaac ggcctactac cagggacagt    480

ccttctgcta gtgttgacac atgcacattt ctgtcatcat tagtgtgctc caataggact    540

ctgctgattg atggccgggc agaactcaaa agaggcctcc agaggcagga gcggcatctt    600

ttcctattca atgatctgtt tgttgtggcc aaaatcaaat ataacaataa ctttaagata    660

aaaaataaaa ttaaattaac tgatatgtgg acagcaagct gtgtggatga agtgggagaa    720

ggcaacacca atgccatgaa atcctttgtt ttgggctggc ccacagtgaa ctttgtggcc    780

actttcagtt ctccagaaca aaaggacaaa tggctctctc tccttcagag atacatcaat    840

ctagagaaag aaaaggacta cccgaagagc attcccctca aaatcttcgc caaggacatt    900

gggaattgtg cctactctaa aactataaca gtaatgaatt cagatacagc gaatgaagtt    960

atcaacatgt cattaccaat gctagggata actggctctg agagagatta ccagttgtgg   1020

gtcaattctg gcaaagaaga ggctccatac ccactcattg ggcatgaata tccatatgga   1080

attaaaatga gccatcttcg agactctgca ctcctgacac cgggatcaaa ggactctacc   1140

acccctttca acctccagga gcccttcctt atggaacagc tcccccgaga gatgcagtgc   1200

cagttcatcc tgaagcccag ccgcctggct gcagcccagc aactgagtga ttcaggtcat   1260

aagacattta aaaggagaag atctatcata aactgggcct tctggcgagg ttctagcact   1320

cacctggaca acttgccctc atcgccaaca tcacctatgc caggacagct ctttggaatt   1380

tctctgccaa atatttgtga gaatgacaat ctgcccaaac ctgtcttgga tatgcttttc   1440

tttcttaatc aaaaaggacc tctcaccaaa ggtatcttca ggcaatcagc caatgtgaaa   1500

tcctgcagag aactaaaaga gaaattgaat tctggagtcg aagtacacct agactgtgaa   1560

tctatttttg tgatagcatc tgtcttaaag gattttctgc gaaatattcc aggaagtatt   1620

ttttcatcag atctctatga tcactgggtc tctgtaatgg atcaaggaaa tgatgaagag   1680

aaaataaata ctgttcaaag gctattagac cagcttccga gagccaatgt tgttctccta   1740

aggtatcttt ttggggtgtt acacaacatt gagcaacatt cctcatccaa tcagatgact   1800

gcatttaatt tagctgtgtg tgtcgctcca agtattcttt ggcctcctgc ttcctccagc   1860

ccagaactag aaaacgaatt tacaaaaaag gtttccctgc ttatacaatt tctgattgag   1920

aattgcctta ggatatttgg agaagaaatc acttccctct tcagagaggt ttcagtgaga   1980

tgtgacacta gagagaatgc ctcagatatt tcttgctttc aactgaatga ctcctcctat   2040

gacagcttgg aaaatgagct aaatgaggat gttgatgcac catgcagtga cttggtaaag   2100

aaacttggcc aggggagcag aagcatggac tctgtcttaa ccctcagtga ctatgatctt   2160

gaccagcccg aggtggaagg ccttttaacc ctaagcgact ttgacttggc ccattctaaa   2220

gatgaagatg ttcaaatgaa acggcctctt gaatccaagc cggtgaacat tttagtgtac   2280

acaaagatcc cactgcggga tcatgccagg gccccatctg ccatgtgcac acccagctac   2340

ctgtccacag ctgcagcaaa tgctgcaaaa agcctgaggc gacaccggcg ttgctcagag   2400

cccagcatcg actatctgga ttcaaagctt tcctacctca gggagtttta tcagaaaaag   2460

ctacgcaagt ccagctgtga tgcaattctt tctcaaaaag atgaagacta tctgaagcag   2520

aatcaacccc tccaggagga aggaaagaca tgttttaaac agagtttagt cacaggcact   2580

gatgtcagca agaaaaatgc cactactcaa aacactaaga agaaaagctt gtctggtagt   2640

gaaggaaatc acgtgaaact tttccctaag tctaagccag tggccatttc tgtggcatct   2700

tatagtccta tgtcctcaca ggatcattcc aagaaccagc cctttgatgt gaatacatct   2760

ggatactccc caccacacac agcagatgcc ctcaagggtc caaggacaca tcggcgctgc   2820

tcagagccca acatagaaga ccagaaccgc aagctgacct atctcagggg aatttattca   2880

aagaaacaac ataaaaccag ctgtgaagct ggtctcttgc atggagagga ggattatctc   2940

aaacggcata agtctttgca aatggagggg cagaagctca ttaatcagag tttagtcatg   3000

gggattgagg tgggcaagag tagtgccaca aaccaaaaca ctgagaaggt tttaccccca   3060

agattaaacc tttgcccaag gaccagctat tccagcttat cctccccagg cacttcccca   3120

tccggctcat cagtaagctc ccaagacagt gctttttctc agatttctga acactctgtg   3180

tttacaccca ctgagacttc ctctccaata gattgcactt ttcaggctca gagaaaacgg   3240

gaagaccttt ctcctgactt tagcaatgcc agccatgttt ccggaatgcc cggtccctca   3300

tcagggcagg cttgcagccg cccagcctat acaaagaagg acaccatgga gtggcattca   3360

caaatgcatt ctgtaactct tcatcccagc acatggttga gaaatggtgt ggccagtttg   3420

aaaaactggt ccctcaaaaa gaaagcaaag gcagccagac cagaggaaga gaaaatagct   3480

tctccaaaag gacccttaga gccaccccca catgcttctg gtgttccaga agccaactca   3540

ctgcaagagg aacaaaaaga cttgccctta agggcagctg aaggactgtc ccctgtgcag   3600

tcagcccaaa ggtgtagttc ttctcccttc caggactcag agagacactg tagctctcca   3660

ttcagcctgg tggagagcag acttaagctg tgcatgaagt cacatgagga aatagagcct   3720

ggtagtcaga gctcttctgg ttctctgcct tgggaaagag cctcagccag ctcttggact   3780

ctagaggatg cgaccagccc agactcaggg cctacagtgg tctgcgacat tgaggacagg   3840

tatttaacca aagacattta agcatagtaa gaatctgatg tccacaagaa caggaactgg   3900

gttaataata atagacaata attattatga cccctttgta taagatacct gggagaggta   3960

gcataaggat tatcattgct aatacttagg acaacgaaat aattctcttt attgagacta   4020

cttgacaaat actttatgct aaaaattttg tcacctaagt gtttgggagg ctttttctta   4080

ttaaaggttg gtattggtcc tgtcatgtgg ttttagagat actaacagag ggctagagaa   4140

agcatcttct gcagaggaag cacttatggg aacagtctgt gagattgatg tcctgagaag   4200

accaagatat caggaatgag gaataggggc ctgaggagag aggggaaggg tacagagaaa   4260

ccatctacat tccatggaat gtttttaata agtaggcaag aaaaatgcca ctaatcaaag   4320

cattaagtgt gtccagtaat aaagaacatc atataaaatc tttccctaaa tctaagccag   4380

tggccatttt tgtgggatct tactaatcac gtgtccttac agaatcattc caagaaccag   4440

cccattgcta cagctagagt ggagaaaaac agagtgactc aaaagccatg ggtaccatga   4500

tatcagtttt gttggttgta tttgtcggtt tgttttttca ttcatgttga agtgctttgc   4560

aaggcttcag gaaacagagt tgtgaggaga aagaagaaaa tggctgccca tttcagtacc   4620

ctttcaaagg tatctctgcc taggaacatt cttcagaaat gcaacttctt ctatttagaa   4680

ggtgacctcc tgacagcgtt cactctcaat atggaggaaa agaccacaac aactgtcctt   4740

tctcaattac acaaatgctg ttaaaatgtg atcaaaccat ggcatcactt tgctgaaatg   4800

tttctgcaca gtcctgcctc ttagattaca gtcagccaga aaaacatact tataaatcat   4860

cccttttctg atttttgtag tttggcaatt gagagagcaa tattgaggtt ggccggttat   4920

aaggagtccc acaatagaat acccaacaaa gtggctgcca ggccttctca gacagccatt   4980

tgctttgggt tttgcttcca gacgttgttc catatttttg ccccaaatgt ttcatggctt   5040

ataccccatt ggtttatttt atatccatgg acctttcttt ctctgctttc ttgacttaaa   5100

ggttgcagca gtacatctcg tcacctagga atagattatc aggccttgcc aactagtatg   5160

cagggatggc actaaaaatg gatgtgcatc ttctttcaca ttaactacta acctataaga   5220

agttgctctg agcccattta tttaaactct ttagttcacc atcagatgga cctttctctc   5280

acaagctagc ttattccaaa ttatttgtct tattaatcac cagaaaatgg tcatatcaaa   5340

tgttctttct tttttgttct aaaggttgca ttttcagtta taggggaaaa aatattttct   5400

ctaagataga agaagttatt tcagtattag ctataggtgc tacctacctc ttggggacat   5460

ggccctgttt gcgctaacca ttacaatgat cttttagaac tctgtatcca aagagctact   5520

tcgtgacact ggccatctga gtcacagatg tgaagtcgat ttcactttat aactaaccag   5580

tcctacatat taagacttct aagtgtccat atgcctcttt tttggtataa tatataaagt   5640

cagcagggac tcccctttcc cttagggcat actactgtca gtcagaactg caagatgtga   5700

atgaagctct taacggcttg gagtgtcttt ctggaagaaa ttgccttttt tttttttttc   5760

atgttagcag gtaaaaaatc attcacccaa tttgaagcat agaagaaaat agttgctgag   5820

gttttttaat aaccattcct actatctgtg ttcccttaga tactcctgta attcttaatg   5880

tgaatagttt gttaatattg ctgtaaagta ttatattgta tgatttgaag acagactata   5940

tgtcatttta ttatactcca tcaatctata atatattaga ctgatgcttt atctaaaatg   6000

ctttgagttt gtataatata tcttgacaaa ttttactacc atatgttatg taataaatgt   6060

gtatttttgt acttgcagaa actgctgcta acttttaaag ttgtttggtt ttcaaggcac   6120

tgataatgga tatgtatgaa gtccatgctg tctgttaaat aaaatgccat tctgcagaat   6180

taaccatcca aaaaaaaaaa aaaaaaa                                       6207


<210>  1722
<211>  1191
<212>  PRT
<213>  Homosapiens

<400>  1722

Met Glu Ala Met Ser Pro Gln Gln Glu Thr Leu Gly Gly Gln Pro Gly 
1               5                   10                  15      


Arg Ser Ser Ser Leu Thr Gly Val Ser Arg Leu Ala Gly Gly Ser Cys 
            20                  25                  30          


Thr Lys Lys Lys Met Lys Thr Leu Ala Glu Arg Arg Arg Ser Ala Pro 
        35                  40                  45              


Ser Leu Ile Leu Asp Lys Ala Leu Gln Lys Arg Pro Thr Thr Arg Asp 
    50                  55                  60                  


Ser Pro Ser Ala Ser Val Asp Thr Cys Thr Phe Leu Ser Ser Leu Val 
65                  70                  75                  80  


Cys Ser Asn Arg Thr Leu Leu Ile Asp Gly Arg Ala Glu Leu Lys Arg 
                85                  90                  95      


Gly Leu Gln Arg Gln Glu Arg His Leu Phe Leu Phe Asn Asp Leu Phe 
            100                 105                 110         


Val Val Ala Lys Ile Lys Tyr Asn Asn Asn Phe Lys Ile Lys Asn Lys 
        115                 120                 125             


Ile Lys Leu Thr Asp Met Trp Thr Ala Ser Cys Val Asp Glu Val Gly 
    130                 135                 140                 


Glu Gly Asn Thr Asn Ala Met Lys Ser Phe Val Leu Gly Trp Pro Thr 
145                 150                 155                 160 


Val Asn Phe Val Ala Thr Phe Ser Ser Pro Glu Gln Lys Asp Lys Trp 
                165                 170                 175     


Leu Ser Leu Leu Gln Arg Tyr Ile Asn Leu Glu Lys Glu Lys Asp Tyr 
            180                 185                 190         


Pro Lys Ser Ile Pro Leu Lys Ile Phe Ala Lys Asp Ile Gly Asn Cys 
        195                 200                 205             


Ala Tyr Ser Lys Thr Ile Thr Val Met Asn Ser Asp Thr Ala Asn Glu 
    210                 215                 220                 


Val Ile Asn Met Ser Leu Pro Met Leu Gly Ile Thr Gly Ser Glu Arg 
225                 230                 235                 240 


Asp Tyr Gln Leu Trp Val Asn Ser Gly Lys Glu Glu Ala Pro Tyr Pro 
                245                 250                 255     


Leu Ile Gly His Glu Tyr Pro Tyr Gly Ile Lys Met Ser His Leu Arg 
            260                 265                 270         


Asp Ser Ala Leu Leu Thr Pro Gly Ser Lys Asp Ser Thr Thr Pro Phe 
        275                 280                 285             


Asn Leu Gln Glu Pro Phe Leu Met Glu Gln Leu Pro Arg Glu Met Gln 
    290                 295                 300                 


Cys Gln Phe Ile Leu Lys Pro Ser Arg Leu Ala Ala Ala Gln Gln Leu 
305                 310                 315                 320 


Ser Asp Ser Gly His Lys Thr Phe Lys Arg Arg Arg Ser Ile Ile Asn 
                325                 330                 335     


Trp Ala Phe Trp Arg Gly Ser Ser Thr His Leu Asp Asn Leu Pro Ser 
            340                 345                 350         


Ser Pro Thr Ser Pro Met Pro Gly Gln Leu Phe Gly Ile Ser Leu Pro 
        355                 360                 365             


Asn Ile Cys Glu Asn Asp Asn Leu Pro Lys Pro Val Leu Asp Met Leu 
    370                 375                 380                 


Phe Phe Leu Asn Gln Lys Gly Pro Leu Thr Lys Gly Ile Phe Arg Gln 
385                 390                 395                 400 


Ser Ala Asn Val Lys Ser Cys Arg Glu Leu Lys Glu Lys Leu Asn Ser 
                405                 410                 415     


Gly Val Glu Val His Leu Asp Cys Glu Ser Ile Phe Val Ile Ala Ser 
            420                 425                 430         


Val Leu Lys Asp Phe Leu Arg Asn Ile Pro Gly Ser Ile Phe Ser Ser 
        435                 440                 445             


Asp Leu Tyr Asp His Trp Val Ser Val Met Asp Gln Gly Asn Asp Glu 
    450                 455                 460                 


Glu Lys Ile Asn Thr Val Gln Arg Leu Leu Asp Gln Leu Pro Arg Ala 
465                 470                 475                 480 


Asn Val Val Leu Leu Arg Tyr Leu Phe Gly Val Leu His Asn Ile Glu 
                485                 490                 495     


Gln His Ser Ser Ser Asn Gln Met Thr Ala Phe Asn Leu Ala Val Cys 
            500                 505                 510         


Val Ala Pro Ser Ile Leu Trp Pro Pro Ala Ser Ser Ser Pro Glu Leu 
        515                 520                 525             


Glu Asn Glu Phe Thr Lys Lys Val Ser Leu Leu Ile Gln Phe Leu Ile 
    530                 535                 540                 


Glu Asn Cys Leu Arg Ile Phe Gly Glu Glu Ile Thr Ser Leu Phe Arg 
545                 550                 555                 560 


Glu Val Ser Val Arg Cys Asp Thr Arg Glu Asn Ala Ser Asp Ile Ser 
                565                 570                 575     


Cys Phe Gln Leu Asn Asp Ser Ser Tyr Asp Ser Leu Glu Asn Glu Leu 
            580                 585                 590         


Asn Glu Asp Val Asp Ala Pro Cys Ser Asp Leu Val Lys Lys Leu Gly 
        595                 600                 605             


Gln Gly Ser Arg Ser Met Asp Ser Val Leu Thr Leu Ser Asp Tyr Asp 
    610                 615                 620                 


Leu Asp Gln Pro Glu Val Glu Gly Leu Leu Thr Leu Ser Asp Phe Asp 
625                 630                 635                 640 


Leu Ala His Ser Lys Asp Glu Asp Val Gln Met Lys Arg Pro Leu Glu 
                645                 650                 655     


Ser Lys Pro Val Asn Ile Leu Val Tyr Thr Lys Ile Pro Leu Arg Asp 
            660                 665                 670         


His Ala Arg Ala Pro Ser Ala Met Cys Thr Pro Ser Tyr Leu Ser Thr 
        675                 680                 685             


Ala Ala Ala Asn Ala Ala Lys Ser Leu Arg Arg His Arg Arg Cys Ser 
    690                 695                 700                 


Glu Pro Ser Ile Asp Tyr Leu Asp Ser Lys Leu Ser Tyr Leu Arg Glu 
705                 710                 715                 720 


Phe Tyr Gln Lys Lys Leu Arg Lys Ser Ser Cys Asp Ala Ile Leu Ser 
                725                 730                 735     


Gln Lys Asp Glu Asp Tyr Leu Lys Gln Asn Gln Pro Leu Gln Glu Glu 
            740                 745                 750         


Gly Lys Thr Cys Phe Lys Gln Ser Leu Val Thr Gly Thr Asp Val Ser 
        755                 760                 765             


Lys Lys Asn Ala Thr Thr Gln Asn Thr Lys Lys Lys Ser Leu Ser Gly 
    770                 775                 780                 


Ser Glu Gly Asn His Val Lys Leu Phe Pro Lys Ser Lys Pro Val Ala 
785                 790                 795                 800 


Ile Ser Val Ala Ser Tyr Ser Pro Met Ser Ser Gln Asp His Ser Lys 
                805                 810                 815     


Asn Gln Pro Phe Asp Val Asn Thr Ser Gly Tyr Ser Pro Pro His Thr 
            820                 825                 830         


Ala Asp Ala Leu Lys Gly Pro Arg Thr His Arg Arg Cys Ser Glu Pro 
        835                 840                 845             


Asn Ile Glu Asp Gln Asn Arg Lys Leu Thr Tyr Leu Arg Gly Ile Tyr 
    850                 855                 860                 


Ser Lys Lys Gln His Lys Thr Ser Cys Glu Ala Gly Leu Leu His Gly 
865                 870                 875                 880 


Glu Glu Asp Tyr Leu Lys Arg His Lys Ser Leu Gln Met Glu Gly Gln 
                885                 890                 895     


Lys Leu Ile Asn Gln Ser Leu Val Met Gly Ile Glu Val Gly Lys Ser 
            900                 905                 910         


Ser Ala Thr Asn Gln Asn Thr Glu Lys Val Leu Pro Pro Arg Leu Asn 
        915                 920                 925             


Leu Cys Pro Arg Thr Ser Tyr Ser Ser Leu Ser Ser Pro Gly Thr Ser 
    930                 935                 940                 


Pro Ser Gly Ser Ser Val Ser Ser Gln Asp Ser Ala Phe Ser Gln Ile 
945                 950                 955                 960 


Ser Glu His Ser Val Phe Thr Pro Thr Glu Thr Ser Ser Pro Ile Asp 
                965                 970                 975     


Cys Thr Phe Gln Ala Gln Arg Lys Arg Glu Asp Leu Ser Pro Asp Phe 
            980                 985                 990         


Ser Asn Ala Ser His Val Ser Gly  Met Pro Gly Pro Ser  Ser Gly Gln 
        995                 1000                 1005             


Ala Cys  Ser Arg Pro Ala Tyr  Thr Lys Lys Asp Thr  Met Glu Trp 
    1010                 1015                 1020             


His Ser  Gln Met His Ser Val  Thr Leu His Pro Ser  Thr Trp Leu 
    1025                 1030                 1035             


Arg Asn  Gly Val Ala Ser Leu  Lys Asn Trp Ser Leu  Lys Lys Lys 
    1040                 1045                 1050             


Ala Lys  Ala Ala Arg Pro Glu  Glu Glu Lys Ile Ala  Ser Pro Lys 
    1055                 1060                 1065             


Gly Pro  Leu Glu Pro Pro Pro  His Ala Ser Gly Val  Pro Glu Ala 
    1070                 1075                 1080             


Asn Ser  Leu Gln Glu Glu Gln  Lys Asp Leu Pro Leu  Arg Ala Ala 
    1085                 1090                 1095             


Glu Gly  Leu Ser Pro Val Gln  Ser Ala Gln Arg Cys  Ser Ser Ser 
    1100                 1105                 1110             


Pro Phe  Gln Asp Ser Glu Arg  His Cys Ser Ser Pro  Phe Ser Leu 
    1115                 1120                 1125             


Val Glu  Ser Arg Leu Lys Leu  Cys Met Lys Ser His  Glu Glu Ile 
    1130                 1135                 1140             


Glu Pro  Gly Ser Gln Ser Ser  Ser Gly Ser Leu Pro  Trp Glu Arg 
    1145                 1150                 1155             


Ala Ser  Ala Ser Ser Trp Thr  Leu Glu Asp Ala Thr  Ser Pro Asp 
    1160                 1165                 1170             


Ser Gly  Pro Thr Val Val Cys  Asp Ile Glu Asp Arg  Tyr Leu Thr 
    1175                 1180                 1185             


Lys Asp  Ile 
    1190     


<210>  1723
<211>  912
<212>  DNA
<213>  Homosapiens

<400>  1723
atgtctaagt cagagtctcc taaagagccc aaacagctaa ggaagctctt cattggaggg     60

ttgaggtttg aaacatcaga tgagagcctg aggagccatt ctgagcaatg gggaacgctc    120

actgaatgtg tggtaatgag agatccaaac accaatcgct ccaggggctt tgggtttgtc    180

ccctatgtca ctgtggagga ggtggatgca gccatgaatg caaggccaca caagatgggt    240

ggaagagttg tggaaccaaa gacagctgtc tcaagagaag attctcaaag accaggtgcc    300

tacttaacag tgaaaaagat atttgttggt ggcattaaag aagacactga agaacatccc    360

ctaagagatt attatgaaca gtatggaaaa actgaagtga ttgaaatcat gactgaccaa    420

ggcagtggca agaaaaggga ctttgccttt gtaacttttg acaaccatga ctccacggat    480

aagattgtca ttcagaaata ccatattgtg aatggccaca actgtgaagt tagaagtggt    540

tctggaaact ttggtggtgg tcgtggaggt ggtttcagtg ggaatgacaa ctttggtcat    600

ggaggaaact tcagtggttg tggtggcttt ggtggcagcc atggtggcag tgcagacggc    660

tataatggat ttggtaatga tggaaagaat tttggaggtg gtagcagcta caatgatttt    720

ggcaattgca acaatcagtc ttcaaatttt ggacccatga agggaggaaa ctttggaggc    780

aaaagatctt gcctctatgg tggtggaggc caatactttg ccaaaccaca aaaccaaggt    840

ggctatgggg gttccagtag cagcagtagc tatggcagtg gcagaagatt tcaattagga    900

aacaaaactt ag                                                        912


<210>  1724
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  1724

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Lys Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Arg Phe Glu Thr Ser Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Ser Glu Gln Trp Gly Thr Leu Thr Glu Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Asn Arg Ser Arg Gly Phe Gly Phe Val Pro Tyr Val Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Met Gly 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Thr Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala Tyr Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His Pro Leu Arg Asp Tyr Tyr Glu Gln Tyr 
        115                 120                 125             


Gly Lys Thr Glu Val Ile Glu Ile Met Thr Asp Gln Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Asp Phe Ala Phe Val Thr Phe Asp Asn His Asp Ser Thr Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Ile Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe 
            180                 185                 190         


Ser Gly Asn Asp Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly 
        195                 200                 205             


Gly Phe Gly Gly Ser His Gly Gly Ser Ala Asp Gly Tyr Asn Gly Phe 
    210                 215                 220                 


Gly Asn Asp Gly Lys Asn Phe Gly Gly Gly Ser Ser Tyr Asn Asp Phe 
225                 230                 235                 240 


Gly Asn Cys Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly 
                245                 250                 255     


Asn Phe Gly Gly Lys Arg Ser Cys Leu Tyr Gly Gly Gly Gly Gln Tyr 
            260                 265                 270         


Phe Ala Lys Pro Gln Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser 
        275                 280                 285             


Ser Ser Tyr Gly Ser Gly Arg Arg Phe Gln Leu Gly Asn Lys Thr 
    290                 295                 300             


<210>  1725
<211>  1957
<212>  DNA
<213>  Homosapiens

<400>  1725
cccggggccg cggagccggg ccggggcagc gccgtctccg cctcggggcc gccgggggcg     60

ccctgctgag cgctacccac gtgcgtccgc gccacctcgc gggcgacccc gcggccaagg    120

cccccggcgg agcggctccc gggcgccccg aactagcccc caactttggg cgaagtttgc    180

ctgcgcctct ccccgccccc acgcggcgcg ccggggccgc ggacggcagc ggcccccggg    240

gatgcgcctt cccggggtac ccctggcgcg ccctgcgctg ctgctgctgc tgccgctgct    300

cgcgccgctg ctgggaacgg gtgcgccggc cgagctgcgg gtccgcgtgc ggctgccgga    360

cggccaggtg accgaggaga gcctgcaggc ggacagcgac gcggacagca tcagcctcga    420

gctgcgcaag cccgacggca ccctcgtctc cttcaccgcc gacttcaaga aggatgtgaa    480

ggtcttccgg gccctgatcc tgggggagct ggagaagggg cagagtcagt tccaggccct    540

ctgctttgtc acccagctgc agcacaatga gatcatcccc agtgaggcca tggccaagct    600

ccggcagaaa aatccccggg cagtgcggca ggcggaggag gttcggggtc tggagcatct    660

gcacatggat gtcgctgtca acttcagcca gggggccctg ctgagccccc atctccacaa    720

cgtgtgtgcc gaggccgtgg atgccatcta cacccgccag gaggatgtcc ggttctggct    780

ggagcaaggt gtggacagtt ctgtgttcga ggctctgccc aaggcctcag agcaggcgga    840

gctgcctcgc tgcaggcagg tgggggacca cgggaagccc tgcgtctgcc gctatggcct    900

gagcctggcc tggtacccct gcatgctcaa gtactgccac agccgcgacc ggcccacgcc    960

ctacaagtgt ggcatccgca gctgccagaa gagctacagc ttcgacttct acgtgcccca   1020

gaggcagctg tgtctctggg atgaggatcc ctacccaggc tagggtggga gcaacctggc   1080

gggtggctgc tctgggccca ctgctcttca ccagccacta gagggggtgg caacccccac   1140

ctgaggcctt atttccctcc ctccccactc ccctggccct agagcctggg cccctctggc   1200

cccatctcac atgactgtga agggggtgtg gcatggcagg gggtctcatg aaggcacccc   1260

cattcccacc ctgtgccttc cttgcgggca gagagggaga gaagggctcc ccagatctac   1320

acccctccct cctgcatctc ccctggagtg ttcacttgca agctgccaaa acatgatggc   1380

ctctggttgt tctgttgaac tccttgaacg tttagaccct aaaaggagtc tatacctgga   1440

cacccacctc cccagacaca actcccttcc ccatgcacac atctggaagg agctggcccc   1500

tcagtccctt cctactcccc aacaaggggc tcactatccc caaagaagga gctgttgggg   1560

acccacgacg cagcccctgt actggattac agcatattct catctctggc cccgaggctg   1620

cctgtggggc gagtggagac ctcccatcac tgagacagat cacagaccac gagtgccttt   1680

cccggacctg gacgttgcct ccagagcagg caccagctct ttccctctct acacagaaat   1740

atttttgtaa ggttctgggg cagggaggga gcatgaagta cgaggaaaac ttgaattcca   1800

gatttttagt gcaaagtatt tatcatttct accagaaata aacgttttaa gtttttactt   1860

gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            1957


<210>  1726
<211>  273
<212>  PRT
<213>  Homosapiens

<400>  1726

Met Arg Leu Pro Gly Val Pro Leu Ala Arg Pro Ala Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Ala Pro Leu Leu Gly Thr Gly Ala Pro Ala Glu Leu 
            20                  25                  30          


Arg Val Arg Val Arg Leu Pro Asp Gly Gln Val Thr Glu Glu Ser Leu 
        35                  40                  45              


Gln Ala Asp Ser Asp Ala Asp Ser Ile Ser Leu Glu Leu Arg Lys Pro 
    50                  55                  60                  


Asp Gly Thr Leu Val Ser Phe Thr Ala Asp Phe Lys Lys Asp Val Lys 
65                  70                  75                  80  


Val Phe Arg Ala Leu Ile Leu Gly Glu Leu Glu Lys Gly Gln Ser Gln 
                85                  90                  95      


Phe Gln Ala Leu Cys Phe Val Thr Gln Leu Gln His Asn Glu Ile Ile 
            100                 105                 110         


Pro Ser Glu Ala Met Ala Lys Leu Arg Gln Lys Asn Pro Arg Ala Val 
        115                 120                 125             


Arg Gln Ala Glu Glu Val Arg Gly Leu Glu His Leu His Met Asp Val 
    130                 135                 140                 


Ala Val Asn Phe Ser Gln Gly Ala Leu Leu Ser Pro His Leu His Asn 
145                 150                 155                 160 


Val Cys Ala Glu Ala Val Asp Ala Ile Tyr Thr Arg Gln Glu Asp Val 
                165                 170                 175     


Arg Phe Trp Leu Glu Gln Gly Val Asp Ser Ser Val Phe Glu Ala Leu 
            180                 185                 190         


Pro Lys Ala Ser Glu Gln Ala Glu Leu Pro Arg Cys Arg Gln Val Gly 
        195                 200                 205             


Asp His Gly Lys Pro Cys Val Cys Arg Tyr Gly Leu Ser Leu Ala Trp 
    210                 215                 220                 


Tyr Pro Cys Met Leu Lys Tyr Cys His Ser Arg Asp Arg Pro Thr Pro 
225                 230                 235                 240 


Tyr Lys Cys Gly Ile Arg Ser Cys Gln Lys Ser Tyr Ser Phe Asp Phe 
                245                 250                 255     


Tyr Val Pro Gln Arg Gln Leu Cys Leu Trp Asp Glu Asp Pro Tyr Pro 
            260                 265                 270         


Gly 
    


<210>  1727
<211>  2868
<212>  DNA
<213>  Homosapiens

<400>  1727
ggggaggatg gtgaatctgg agtccatgca cacagatatc aagatgagtg gggatgtagc     60

cgattccacg gatgctcgca gcactctcag ccaggtggag ccaggaaatg atcgaaaagg    120

cctagatttc aacaggcaga ttaaaaccga agatctcagt gactccctgc agcagaccct    180

ctcccatcgg ccatgccacc tgagtcaagg acctgccatg atgtccggaa accaaatgtc    240

tgggctaaat gccagcccat gtcaggacat ggcttccctc catccgctcc agcagcttgt    300

gctggttccc ggccacttac agtctgtatc ccagttcctg ctatctcaga cccagcctgg    360

gcagcaaggt ctgcagccaa atctcctccc ctttccacag caacaaagcg gtctcctcct    420

cccacagact gggccgggac tggcatccca ggcatttggg caccctgggc tgccaggatc    480

ctctttagaa ccccacctgg aagcatccca gcatctccca gtgcccaagc atctacccag    540

ctctggaggg gccgatgagc ccagtgacct cgaggagctg gagaagtttg ccaagacctt    600

caagcagagg cgcattaagc tgggcttcac acagggagat gtggggctgg cgatgggaaa    660

gctgtatggc aacgacttca gccagaccac catctcacga tttgaggccc tcaacctgag    720

cttcaagaac atgtgcaagc tcaagcccct gctggagaag tggctgaatg atgcagagtc    780

ctctccgtca gacccctcag tgagcacgcc cagctcctac cccagcctca gtgaagtatt    840

tggtaggaag agaaagaaac ggaccagcat cgagaccaac atccgcctga ctctggagaa    900

gaggtttcaa gataacccaa aacccagctc ggaggagatc tccatgattg cagagcagtt    960

gtccatggag aaggaggtgg tgagggtctg gttctgcaac cgacgccaaa aggagaagcg   1020

aatcaactgc cctgtggcca cacccatcaa accacctgtc tacaactccc ggctggtatc   1080

tccctcaggg tctctgggcc ccctctctgt ccctcctgtc cacagtacca tgcctggaac   1140

agtaacgtca tcctgttccc ctgggaacaa cagcaggcct tcatctcctg gctcaggact   1200

ccacgccagc agccccactg catctcaaaa taactccaaa gcagcagtga actccgcctc   1260

cagttttaac tcttcaggat cttggtaccg atggaatcat tccacctacc tccactgaga   1320

ccaaaaagtt tctcctactc cagctggccc tgtattcccc tggaaggaag ggaatcatgc   1380

cttctatata cagacagatt gccttcagaa gagtggaaga aaatctccac tatcaatgaa   1440

cccagactct tgtcttcttc aagagcaagg gcctccggag atccaaactg tgattgaacc   1500

aagtgcagac tcctaatgct cttgaaatac acagcccctc ctaggagctt accattttca   1560

ccttccttgc ctatgccctt gccttctagt tccaaatatt ttagccagct tcactgtggc   1620

aatagtcttt cagagaaaag acttcttgct gttattctcc aactcatccg tgggcttctg   1680

gggacagcca tttggctggg gtgccaaaca ccagaagggg agataatagt tttgactctg   1740

aacttggcca caacccctga actgatccca aaatctgtga aaagatttga atctgatatc   1800

tccaccaaag ccttgatgtt ttctctgtac agctaagttt tctgatggaa tcttcatctc   1860

accccatttt ctttttaacc tcgccccctt ttctacaatc aaatccattc attattgcgc   1920

cctccaggtc ccctcctttt tgcagaaggt gtaaaagagc tgcccttggt gggtgccctt   1980

gagcatgttg caacgcctgc tggtgccctt ctgtctgtcc acgtctgcct agggctcagg   2040

agtgcttgtt ctttccctgg cgccctgggt ttctctttat cctgtcccct ctcctttctc   2100

ctggcagcag aaaaggaaga acacaagagc aaacacacaa caatgatggt ggcaaagtac   2160

ctgtatatag ccctttccca tttttgcatt atgttcttaa ctccttaatg tggaattttc   2220

cagcaaaatg tttaactcag gtgtgatttt tgaaaatgtc tctgtaatat tttatcttct   2280

ttaaaaaaaa gggggggaaa taccaaagtg tgaaatactg tgctaccttc cagagttccc   2340

acatgggctg ggattttttt ttctttttct tttttttttt tttttttgag acagtcttgc   2400

tccagcccag gctggagtgc agtggcatga tcttggctca ctgcatgctc tgccacttgg   2460

gttcaagcga ttctcctgcc tcagcctctc aagtagcgga ttacaggcgc ccaccaccaa   2520

aaattagccc agctaatttt tgtattttta gtagagatgg ggtttcacca tgttggtcag   2580

gctggtcttg aactcctgac ctcctgatcc acccacctca gcgtcccgaa gtgctgggat   2640

tacaggtgtg agccaccgcg cctggcctgg gctgggaatc tttgttgact tctttgggaa   2700

cattatctct agagtctgct tttttgtggg ccagtttgta gagatgtaac atgaagccat   2760

tccagaaatg gtaacttaaa aaaaaaaaga ctacatgtct aggaaactgt tgagattcaa   2820

aggaatctca ctgttcctaa ataaatgtgt atagtgatta tgaaaagt                2868


<210>  1728
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  1728

Met Val Asn Leu Glu Ser Met His Thr Asp Ile Lys Met Ser Gly Asp 
1               5                   10                  15      


Val Ala Asp Ser Thr Asp Ala Arg Ser Thr Leu Ser Gln Val Glu Pro 
            20                  25                  30          


Gly Asn Asp Arg Lys Gly Leu Asp Phe Asn Arg Gln Ile Lys Thr Glu 
        35                  40                  45              


Asp Leu Ser Asp Ser Leu Gln Gln Thr Leu Ser His Arg Pro Cys His 
    50                  55                  60                  


Leu Ser Gln Gly Pro Ala Met Met Ser Gly Asn Gln Met Ser Gly Leu 
65                  70                  75                  80  


Asn Ala Ser Pro Cys Gln Asp Met Ala Ser Leu His Pro Leu Gln Gln 
                85                  90                  95      


Leu Val Leu Val Pro Gly His Leu Gln Ser Val Ser Gln Phe Leu Leu 
            100                 105                 110         


Ser Gln Thr Gln Pro Gly Gln Gln Gly Leu Gln Pro Asn Leu Leu Pro 
        115                 120                 125             


Phe Pro Gln Gln Gln Ser Gly Leu Leu Leu Pro Gln Thr Gly Pro Gly 
    130                 135                 140                 


Leu Ala Ser Gln Ala Phe Gly His Pro Gly Leu Pro Gly Ser Ser Leu 
145                 150                 155                 160 


Glu Pro His Leu Glu Ala Ser Gln His Leu Pro Val Pro Lys His Leu 
                165                 170                 175     


Pro Ser Ser Gly Gly Ala Asp Glu Pro Ser Asp Leu Glu Glu Leu Glu 
            180                 185                 190         


Lys Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr 
        195                 200                 205             


Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe 
    210                 215                 220                 


Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys 
225                 230                 235                 240 


Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala 
                245                 250                 255     


Glu Ser Ser Pro Ser Asp Pro Ser Val Ser Thr Pro Ser Ser Tyr Pro 
            260                 265                 270         


Ser Leu Ser Glu Val Phe Gly Arg Lys Arg Lys Lys Arg Thr Ser Ile 
        275                 280                 285             


Glu Thr Asn Ile Arg Leu Thr Leu Glu Lys Arg Phe Gln Asp Asn Pro 
    290                 295                 300                 


Lys Pro Ser Ser Glu Glu Ile Ser Met Ile Ala Glu Gln Leu Ser Met 
305                 310                 315                 320 


Glu Lys Glu Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu 
                325                 330                 335     


Lys Arg Ile Asn Cys Pro Val Ala Thr Pro Ile Lys Pro Pro Val Tyr 
            340                 345                 350         


Asn Ser Arg Leu Val Ser Pro Ser Gly Ser Leu Gly Pro Leu Ser Val 
        355                 360                 365             


Pro Pro Val His Ser Thr Met Pro Gly Thr Val Thr Ser Ser Cys Ser 
    370                 375                 380                 


Pro Gly Asn Asn Ser Arg Pro Ser Ser Pro Gly Ser Gly Leu His Ala 
385                 390                 395                 400 


Ser Ser Pro Thr Ala Ser Gln Asn Asn Ser Lys Ala Ala Val Asn Ser 
                405                 410                 415     


Ala Ser Ser Phe Asn Ser Ser Gly Ser Trp Tyr Arg Trp Asn His Ser 
            420                 425                 430         


Thr Tyr Leu His 
        435     


<210>  1729
<211>  922
<212>  DNA
<213>  Homosapiens

<400>  1729
gcgatccggg ccgggagctg cgggcgcccg ggcgcccgag gcttcccggt gcgctccgcc     60

aggtcagtca tcgctagagg gttattattg acatttactc atcataaaat gtgatgtcag    120

cctaccagct cggagtgcag ttcctggttt ccagtttaca acattgacca gttgctaaca    180

tgttatctct gaggaacttg gaatgataaa tacagccata cttaaataga agattcttgg    240

ccgtgtagat aaggaaaata agataaggca atatttttga actattctat aatagaaatg    300

aggatatata cacaaaatga cccagtgctg ttttcttagg gtgcatcctt tgtttttctg    360

gttttggtct tttcatcaca ggatggcatt agctctgtgt ctgcaggtgc tgtgcagcct    420

gtgtggctgg ctctcgctct atatttcttt ctgccacctg aataagcacc gaagctatga    480

gtggagctgc cgcctggtca ccttcaccca tggagtcctc tctataggcc tctccgctta    540

tattggcttc attgatggcc catggccttt tacccaccca ggctcaccca atacacctct    600

ccaagttcat gtcctgtgtc tcaccttggg ctacttcatc ttcgacttgg gctgcatctg    660

gcgctttgca tggaggaaga gcatcaagaa gtaccatgct tggagaagca ggcggagtga    720

ggaacggcag ctgaaacaca acggacatct caaaatacac tagccaaggc ttgctccaga    780

ttatggattg ggttaagtca gccatgggaa ccaggttgga aatatgactg ttacataatt    840

acacttataa caaacttagg tttcaataaa gggctaaatg tattgaaaaa aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaaa aa                                             922


<210>  1730
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  1730

Met Thr Gln Cys Cys Phe Leu Arg Val His Pro Leu Phe Phe Trp Phe 
1               5                   10                  15      


Trp Ser Phe His His Arg Met Ala Leu Ala Leu Cys Leu Gln Val Leu 
            20                  25                  30          


Cys Ser Leu Cys Gly Trp Leu Ser Leu Tyr Ile Ser Phe Cys His Leu 
        35                  40                  45              


Asn Lys His Arg Ser Tyr Glu Trp Ser Cys Arg Leu Val Thr Phe Thr 
    50                  55                  60                  


His Gly Val Leu Ser Ile Gly Leu Ser Ala Tyr Ile Gly Phe Ile Asp 
65                  70                  75                  80  


Gly Pro Trp Pro Phe Thr His Pro Gly Ser Pro Asn Thr Pro Leu Gln 
                85                  90                  95      


Val His Val Leu Cys Leu Thr Leu Gly Tyr Phe Ile Phe Asp Leu Gly 
            100                 105                 110         


Cys Ile Trp Arg Phe Ala Trp Arg Lys Ser Ile Lys Lys Tyr His Ala 
        115                 120                 125             


Trp Arg Ser Arg Arg Ser Glu Glu Arg Gln Leu Lys His Asn Gly His 
    130                 135                 140                 


Leu Lys Ile His 
145             


<210>  1731
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1731
ggccccaatg agtggcacac agtctactat caccgacagg tttcccctca aaaaacctat     60

aaggcatgga agtattttga accgagagtc accaacagat aagaagcaga aagttgagcg    120

cattgcatca catgattttg accccacaga tagctcctcc aagaagacaa agtctagttc    180

agaggagagt agatccgaga tatatggtct tgttcagcgt tgcgtaatca tccagaaaga    240

tgacaatgga tttgggctga cggtcagtgg agacaatcca gtcttcgtac agtctgtcaa    300

agaagatgga gcagccatgc gggctggagt acagacaggt gatcgaatca tcaaggtgaa    360

tggaactctg gtgactcatt caaatcatct ggaggtggtg aagctaatca aatctggttc    420

ctatgtagct ctcactgttc agggacgccc acctgggtcg ccccagattc cacttgccga    480

ctctgaagta gagccgtcag tcattggaca tatgtctccc atcatgacat ctcctcattc    540

acctggagca tctgggaata tggagagaat cactagtcct gtgctcatgg gggaggaaaa    600

caatgtggtt cataaccaga aagtagaaat tctgagaaaa atgttacaga aagaacagga    660

acggctacag ttattgcagg aagattacaa ccgaacacct gcccaaagat tgctaaaaga    720

gatccaagag gccaagaaac acattcctca gctgcaagag cagttatcca aagccacagg    780

ctctgctcag gatggagctg tagttacacc ctccagacct ttaggggaca ccctaacagt    840

cagtgaggca gaaacagatc ctggagatgt actgggcagg actgactgta gcagtggaga    900

tgcttctcgg cccagtagtg acaatgcaga tagtcccaag agtggcccaa aagagagaat    960

ttatctagag gaaaacccag agaaaagtga aacaattcag gacactgaca ctcaatcact   1020

tgtcggaagt ccctcaaccc gtatagcacc tcatattatt ggagcagaag atgatgattt   1080

tggtactgaa catgaacaga tcaatggaca gtgcagctgt ttccagagca ttgaattact   1140

aaaatctcgc ccggctcatt tggctgtttt cttacaccat gtagtttcac aatttgaccc   1200

tgcgactttg ctctgttatc tctattcaga cctgtataaa cataccaatt ccaaagaaac   1260

tcgtcgcatc ttccttgagt ttcatcagtt ctttctagat cgatcagcac acctgaaagt   1320

ttctgttcct gatgaaatgt ctgcagatct agaaaagaga agacctgagc tcattcctga   1380

ggatctgcat cgccactata tccaaactat gcaagaaaga gtccatccag aagttcaaag   1440

gcacttagaa gattttcggc agaaacgtag tatgggactg accttggctg aaagcgagct   1500

gactaaactt gatgcagagc gagacaagga ccgattgact ttggagaagg agcggacatg   1560

tgcagaacag attgttgcca aaattgaaga agtattgatg actgctcagg ctgtagagga   1620

agataagagc tccaccatgc agtatgttat tctcatgtat atgaagcatt tgggagtaaa   1680

agtgaaagag cctcgaaatt tggagcacaa acggggtcgg attggatttc ttcccaaaat   1740

caagcaaagt atgaagaaag ataaagaagg ggaagaaaaa gggaagcgaa gaggattccc   1800

cagcatcctg ggacccccac ggagaccaag ccgtcatgac aacagtgcaa ttggcagagc   1860

catggaacta cagaaggcgc gccaccctaa gcacttatcc acaccctcat ctgtgagtcc   1920

tgaacctcag gactctgcca agttgcgcca gagtgggtta gcaaatgaag gaacagacgc   1980

tggatacctg cctgccaatt ccatgtcttc tgtagcttca ggggcctctt tttcccagga   2040

aggagggaaa gagaatgata caggatcaaa gcaagttgga gaaacatcag cacctggaga   2100

caccttagat ggcacacctc gtactctcaa tactgtcttt gatttcccac cacctccatt   2160

agaccaagtg caggaggagg aatgtgaagt agaaagggtg actgaacatg ggacaccaaa   2220

gccctttcga aagtttgaca gtgtagcttt tggagaaagt caaagtgagg atgaacaatt   2280

tgaaaatgac ttagagacag acccacccaa ctggcagcag cttgttagtc gagaagtgtt   2340

actgggacta aaaccttgtg aaatcaaaag acaggaagtg attaatgaat tgttctacac   2400

tgaaagagct catgttcgaa cactgaaggt tcttgatcaa gtgttctatc agcgagtatc   2460

cagagaagga attctgtcac cctcagagct acggaaaatt ttttcaaact tggaagatat   2520

tcttcaactt catattggat tgaatgaaca aatgaaggct gttcgaaaga gaaatgagac   2580

ctctgttatc gatcagattg gggaagattt gctgacatgg ttcagcggac caggagagga   2640

gaaattgaaa catgctgctg ctaccttttg cagtaaccaa cctttcgccc tggaaatgat   2700

caaatctcgt cagaaaaagg attctcgatt tcagactttt gtgcaagatg ctgaaagtaa   2760

tccactgtgt cgtcgtcttc aactgaagga tattattccc actcaaatgc aaaggcttac   2820

taagtaccca cttctgttgg ataatattgc caaatacaca gaatggccaa cagaaaggga   2880

gaaggtgaag aaagctgcag atcactgtcg tcagatctta aattatgtaa atcaggctgt   2940

caaggaggca gaaaacaagc agcgcctaga agattatcag cgtcgccttg atacctccag   3000

cctgaagttg tcagagtacc caaatgttga agagctcagg aatttggatt taacaaaaag   3060

gaagatgatt catgaagggc cattggtttg gaaggtgaat agagataaaa ctattgattt   3120

atacacgttg ctgctggaag acattcttgt attgttacaa aagcaggatg atagactggt   3180

tttaaggtgt catagtaaga ttctggcatc tacagctgat agcaaacaca cgtttagccc   3240

tgtcattaag ttgagtacag tgttggttcg acaagtggca acagataaca aagctttatt   3300

cgtcatttcc atgtcagaca atggcgctca gatttatgaa ctggtggcac agacagtttc   3360

tgaaaagact gtctggcagg acctaatctg tcggatggct gcatcagtga aggagcaatc   3420

cacaaagcca attccattac cacagtcaac acctggcgaa ggagataatg atgaagaaga   3480

tccttcaaaa ttaaaagagg agcagcatgg catttcagtc actggtttgc agagtccaga   3540

cagagatttg ggattagaat ctaccttaat atcgtcaaaa cctcagtctc attcactgag   3600

tacctctggg aaatcagagg tacgtgatct gtttgtggct gagagacagt ttgcaaagga   3660

acaacataca gatgggacac taaaggaagt tggagaagat tatcaaatcg caatcccaga   3720

ttcacacctg cctgtctcag aagaacggtg ggcattggat gcactaagaa atttgggttt   3780

gttgaagcag ttgctggtgc aacagctagg tttgactgag aagagcgttc aggaagactg   3840

gcaacatttc ccaagataca gaacagcctc tcaggggccg cagacagaca gtgtcatcca   3900

gaactctgaa aatattaagg cctatcattc tggtgaagga catatgccct ttagaactgg   3960

aactggtgac attgcaactt gttacagtcc acggacttca actgaatctt ttgctccacg   4020

ggattcagtg ggactggcac cccaggatag ccaggcaagt aacattttag taatggacca   4080

catgattatg accccagaga tgcctaccat ggagccagaa gggggtcttg atgacagtgg   4140

agagcacttt tttgatgccc gtgaagcaca tagtgatgag aatccatcag aaggtgatgg   4200

agcagttaac aaggaagaga aggatgttaa tttacgcatc tcaggaaact atttgatcct   4260

tgatggctat gacccagtgc aggagagttc cacagatgag gaggttgctt cctcacttac   4320

cctgcagccc atgacaggca tccctgctgt ggaatccacc caccagcagc aacattctcc   4380

tcagaatact cactccgatg gggcaatttc accattcacc cccgaatttc tggtccagca   4440

gcgctgggga gctatggagt attcctgttt tgagatccag agtccctcct cttgtgcaga   4500

ttcacagagc cagatcatgg agtacattca taagatagag gctgaccttg aacacttaaa   4560

gaaggtggag gaaagttaca ccattctttg ccaaaggctg gctggatcag ccctcacaga   4620

caagcactca gataaaagtt agagccgcat gtcctggagg tgactgcagg ttgttggatt   4680

tggagtatcg gccgtgtctc accacatcct ggctccagtg tggatgcaga gagagtgtga   4740

cagaggatct gcctgtgaac cacctgggat tagtcaagtc ccaaggtgcc cagagtggga   4800

ctagttcttc acagtgtggc agctgcacta atctgtttgt gagggaatat ccattccctc   4860

actctactct cctcactatc ggaaattcat tttgattcag aataaaaacc aaatgtatag   4920

agctttgggt gtaggatatg aaattgtact tagatttaag aaaaagagaa aatcagatgt   4980

atttatttga cttcattccg tatttgaaag cacattttaa tttttatttg ccttgttttg   5040

ttttaattga gtagtgagag ttttagacct ttgtctttag tacacccaag gatcaactgc   5100

tcctgaagca aagaggtcag gatggagtat gcagaagttg ggtagagagg ttaagaagag   5160

gaggaagtga gacggggaag ggaggagcac cttgcttcac tatacagtat tccaagctct   5220

ctgctgtcca gtaggctgct tctctgaggg tcacctcaaa ggtatgctat gccgtgtggc   5280

tcttatgtgc ccaggtggtg tggtcagaga gtggatgggc ttcctcccgc cctgaggcaa   5340

gcacctcttc tctgtagctg ggatcaacca caattaatag gaatcctcaa catactaaat   5400

agcaggcact tgaaaatggg tgtgttttct tccattgtcg tcttttctat tgagggttgg   5460

gatttgggtg ggagaggaaa gcaaatttta ttttcttgac tataaatttg ttattcttgg   5520

tatcatttca tttttataat tatacattag acattggcac ttgtgtaaaa ctgtccctgc   5580

agattgagca ggaagtaaaa acaaatggaa atgcttcgga tagtggcagg ggtgggggtt   5640

gctaaggaaa gggtgggatg ggagtgggta aagagtttgg gaaggttatc taactgaatc   5700

actactgagt tgaatcatgg ctatcattag ccacaggtac tgctgattat aaggccagta   5760

aaattttagt acctggaggt ttgactctaa tttttgcact gatggtgcca aagggccctg   5820

agtcaaaagg atagccaagg gtggagtgga aaaagatatg gtgaaggcag aactgctcac   5880

accagctcca gaagcacgtc ctctgacttc actgccgcag ctctttccac acggggccgt   5940

gattgaccct aaaaattgca gaccagcaca tacactggac actgcaggca aggtgttggt   6000

aactgcctgc tctaggatga atagtagcgt tagcagcacc ctacagaggg taagtttcag   6060

aattgtaatt tgagaactcc ttcaattata ttgactttct ttggttttcc ttgtgcatta   6120

ggtatatatt ttttgaagta tttttgccaa ctaaaatgaa gtctgtaaat tctgttaata   6180

aacaaggagt tcatccgttg ctcacatctt tcattggtgc cctctgaact ctgtgggttg   6240

ctaggatgta attttaatgc ttccctgcag tccaaagatg attttttcac cacaaatggt   6300

aagggatgcc cacctacttt tataaacacc actgcaactt aacaagttta tttatctatg   6360

tccagatttc tgtttctgtc ctaaattgat ctgtgttttt aggtggatca acttggatct   6420

ttagacctca tctataaatt gaaattatat ttttagtcat aagccaagta caatctaact   6480

cagaatggga ttaaaaattt tagaagcaga agctaatata taaatgaagt ttgggatttg   6540

gaactttctg tatctcttag gaggaacaag taaaaaccaa atggttacat tgtgctgcta   6600

gaaataatgt cattctcaat taaaagggtt acacctgtag ccacttgaca ctaacaccat   6660

cgagggcaat taatcaggag aaaagtaaat ataaaaactt tgctcttaac gtcacacact   6720

acagggtaat tatgtaattc tctagcactc aattaagaag cttgtaggtt agcaaaattt   6780

cagtttctct agttcagcca gtgtcttgtc cttagtaatt atttgctttc cctgcagttc   6840

aatttctcct tggaactcta acaggactaa ctggaaaaat actttgacca tagctctagt   6900

acttccaaat aaattcatat ctagattttc aaacaaagcc ccaagatgaa gtctaattct   6960

gaaaatatct cacaattttt gaatgttctt tttatcttac cgacctaact tctcttttcc   7020

ctcccaactt ggcctcccac acgttccatt tcattttggc cattatagtc acatccgttt   7080

gactttggtt gtgacatctt cctttcagga tgatggaatt agatgcagtc tgtctttgag   7140

tgagactggt caccatcaga ggagtttttt ctaagtgacg tgactagaag ttgaaatcta   7200

cttccctgct aaagggcaca ggggtggtgt acaaagaaag ctaccttccc agagcaagca   7260

ggctgcattt tagctatgga agtgacctgc tgtgacactg tgctctcttc tgtgggctta   7320

atggttcctt tgctatgaag tggcaaatta catgtagagt gtctccttcc ttttcagaga   7380

acagttaatc aaggcaaatc agcaagcccc caaagtgctg taatttaaca tcatgattac   7440

caccttcgaa gctatatatt ttgcatactt taaaatcacc taacttggac tgcttgaatt   7500

acattggctt ttagaaccga aattgtaact atgtattgta tttcatggga ggtatatttt   7560

atgagctttt tggctttctt ttttcccaca gcaactgcca atgaaggatg aatccccttt   7620

ttaaaaagtt gttgttgttg ttgtttattt gattttgagt taggagggat aatagagaag   7680

tccatttaaa aattattttt agaagctaaa gaaagtaatt atgcttcctg tgaattgtct   7740

tttactggca tctttgtttt cctctttgat gttagtaaat ttggtgtaat acgtggggct   7800

tccatatttc aaagtggaag ctttcttctc tgaagtcgat atatggtttt gaattactag   7860

agctttggtc agtatttcct tccctatatg tcacagaggg caccactgag aactgcgtgc   7920

ataggacctc aaaatacaaa attagcaggg cctcacagtc agcttcctca tggctagttt   7980

ttccccctta tattacaatt tttgttttat aagtcatttt tttcctgata tttccaccac   8040

ttttcagagt catctacaaa atttttcttt cctcaagaaa agagttcctt ttgccttatt   8100

ccttatgcct tccccactgg tattgagggt tttgataata aattggtagg aaaaaaaagt   8160

acctcctaga aggaagcctt ccccaccatt tc                                 8192


<210>  1732
<211>  1544
<212>  PRT
<213>  Homosapiens

<400>  1732

Met Ser Gly Thr Gln Ser Thr Ile Thr Asp Arg Phe Pro Leu Lys Lys 
1               5                   10                  15      


Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Thr Asp Lys 
            20                  25                  30          


Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Thr Asp 
        35                  40                  45              


Ser Ser Ser Lys Lys Thr Lys Ser Ser Ser Glu Glu Ser Arg Ser Glu 
    50                  55                  60                  


Ile Tyr Gly Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn 
65                  70                  75                  80  


Gly Phe Gly Leu Thr Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser 
                85                  90                  95      


Val Lys Glu Asp Gly Ala Ala Met Arg Ala Gly Val Gln Thr Gly Asp 
            100                 105                 110         


Arg Ile Ile Lys Val Asn Gly Thr Leu Val Thr His Ser Asn His Leu 
        115                 120                 125             


Glu Val Val Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Thr Val 
    130                 135                 140                 


Gln Gly Arg Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu 
145                 150                 155                 160 


Val Glu Pro Ser Val Ile Gly His Met Ser Pro Ile Met Thr Ser Pro 
                165                 170                 175     


His Ser Pro Gly Ala Ser Gly Asn Met Glu Arg Ile Thr Ser Pro Val 
            180                 185                 190         


Leu Met Gly Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln 
    210                 215                 220                 


Glu Asp Tyr Asn Arg Thr Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln 
225                 230                 235                 240 


Glu Ala Lys Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala 
                245                 250                 255     


Thr Gly Ser Ala Gln Asp Gly Ala Val Val Thr Pro Ser Arg Pro Leu 
            260                 265                 270         


Gly Asp Thr Leu Thr Val Ser Glu Ala Glu Thr Asp Pro Gly Asp Val 
        275                 280                 285             


Leu Gly Arg Thr Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser 
    290                 295                 300                 


Asp Asn Ala Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu 
305                 310                 315                 320 


Glu Glu Asn Pro Glu Lys Ser Glu Thr Ile Gln Asp Thr Asp Thr Gln 
                325                 330                 335     


Ser Leu Val Gly Ser Pro Ser Thr Arg Ile Ala Pro His Ile Ile Gly 
            340                 345                 350         


Ala Glu Asp Asp Asp Phe Gly Thr Glu His Glu Gln Ile Asn Gly Gln 
        355                 360                 365             


Cys Ser Cys Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His 
    370                 375                 380                 


Leu Ala Val Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Thr 
385                 390                 395                 400 


Leu Leu Cys Tyr Leu Tyr Ser Asp Leu Tyr Lys His Thr Asn Ser Lys 
                405                 410                 415     


Glu Thr Arg Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg 
            420                 425                 430         


Ser Ala His Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu 
        435                 440                 445             


Glu Lys Arg Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr 
    450                 455                 460                 


Ile Gln Thr Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu 
465                 470                 475                 480 


Glu Asp Phe Arg Gln Lys Arg Ser Met Gly Leu Thr Leu Ala Glu Ser 
                485                 490                 495     


Glu Leu Thr Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu 
            500                 505                 510         


Glu Lys Glu Arg Thr Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu 
        515                 520                 525             


Val Leu Met Thr Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Thr Met 
    530                 535                 540                 


Gln Tyr Val Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys 
545                 550                 555                 560 


Glu Pro Arg Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro 
                565                 570                 575     


Lys Ile Lys Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly 
            580                 585                 590         


Lys Arg Arg Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser 
        595                 600                 605             


Arg His Asp Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala 
    610                 615                 620                 


Arg His Pro Lys His Leu Ser Thr Pro Ser Ser Val Ser Pro Glu Pro 
625                 630                 635                 640 


Gln Asp Ser Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Thr 
                645                 650                 655     


Asp Ala Gly Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly 
            660                 665                 670         


Ala Ser Phe Ser Gln Glu Gly Gly Lys Glu Asn Asp Thr Gly Ser Lys 
        675                 680                 685             


Gln Val Gly Glu Thr Ser Ala Pro Gly Asp Thr Leu Asp Gly Thr Pro 
    690                 695                 700                 


Arg Thr Leu Asn Thr Val Phe Asp Phe Pro Pro Pro Pro Leu Asp Gln 
705                 710                 715                 720 


Val Gln Glu Glu Glu Cys Glu Val Glu Arg Val Thr Glu His Gly Thr 
                725                 730                 735     


Pro Lys Pro Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln 
            740                 745                 750         


Ser Glu Asp Glu Gln Phe Glu Asn Asp Leu Glu Thr Asp Pro Pro Asn 
        755                 760                 765             


Trp Gln Gln Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys 
    770                 775                 780                 


Glu Ile Lys Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Thr Glu Arg 
785                 790                 795                 800 


Ala His Val Arg Thr Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg 
                805                 810                 815     


Val Ser Arg Glu Gly Ile Leu Ser Pro Ser Glu Leu Arg Lys Ile Phe 
            820                 825                 830         


Ser Asn Leu Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln 
        835                 840                 845             


Met Lys Ala Val Arg Lys Arg Asn Glu Thr Ser Val Ile Asp Gln Ile 
    850                 855                 860                 


Gly Glu Asp Leu Leu Thr Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu 
865                 870                 875                 880 


Lys His Ala Ala Ala Thr Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu 
                885                 890                 895     


Met Ile Lys Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Thr Phe Val 
            900                 905                 910         


Gln Asp Ala Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp 
        915                 920                 925             


Ile Ile Pro Thr Gln Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu 
    930                 935                 940                 


Asp Asn Ile Ala Lys Tyr Thr Glu Trp Pro Thr Glu Arg Glu Lys Val 
945                 950                 955                 960 


Lys Lys Ala Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln 
                965                 970                 975     


Ala Val Lys Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg 
            980                 985                 990         


Arg Leu Asp Thr Ser Ser Leu Lys  Leu Ser Glu Tyr Pro  Asn Val Glu 
        995                 1000                 1005             


Glu Leu  Arg Asn Leu Asp Leu  Thr Lys Arg Lys Met  Ile His Glu 
    1010                 1015                 1020             


Gly Pro  Leu Val Trp Lys Val  Asn Arg Asp Lys Thr  Ile Asp Leu 
    1025                 1030                 1035             


Tyr Thr  Leu Leu Leu Glu Asp  Ile Leu Val Leu Leu  Gln Lys Gln 
    1040                 1045                 1050             


Asp Asp  Arg Leu Val Leu Arg  Cys His Ser Lys Ile  Leu Ala Ser 
    1055                 1060                 1065             


Thr Ala  Asp Ser Lys His Thr  Phe Ser Pro Val Ile  Lys Leu Ser 
    1070                 1075                 1080             


Thr Val  Leu Val Arg Gln Val  Ala Thr Asp Asn Lys  Ala Leu Phe 
    1085                 1090                 1095             


Val Ile  Ser Met Ser Asp Asn  Gly Ala Gln Ile Tyr  Glu Leu Val 
    1100                 1105                 1110             


Ala Gln  Thr Val Ser Glu Lys  Thr Val Trp Gln Asp  Leu Ile Cys 
    1115                 1120                 1125             


Arg Met  Ala Ala Ser Val Lys  Glu Gln Ser Thr Lys  Pro Ile Pro 
    1130                 1135                 1140             


Leu Pro  Gln Ser Thr Pro Gly  Glu Gly Asp Asn Asp  Glu Glu Asp 
    1145                 1150                 1155             


Pro Ser  Lys Leu Lys Glu Glu  Gln His Gly Ile Ser  Val Thr Gly 
    1160                 1165                 1170             


Leu Gln  Ser Pro Asp Arg Asp  Leu Gly Leu Glu Ser  Thr Leu Ile 
    1175                 1180                 1185             


Ser Ser  Lys Pro Gln Ser His  Ser Leu Ser Thr Ser  Gly Lys Ser 
    1190                 1195                 1200             


Glu Val  Arg Asp Leu Phe Val  Ala Glu Arg Gln Phe  Ala Lys Glu 
    1205                 1210                 1215             


Gln His  Thr Asp Gly Thr Leu  Lys Glu Val Gly Glu  Asp Tyr Gln 
    1220                 1225                 1230             


Ile Ala  Ile Pro Asp Ser His  Leu Pro Val Ser Glu  Glu Arg Trp 
    1235                 1240                 1245             


Ala Leu  Asp Ala Leu Arg Asn  Leu Gly Leu Leu Lys  Gln Leu Leu 
    1250                 1255                 1260             


Val Gln  Gln Leu Gly Leu Thr  Glu Lys Ser Val Gln  Glu Asp Trp 
    1265                 1270                 1275             


Gln His  Phe Pro Arg Tyr Arg  Thr Ala Ser Gln Gly  Pro Gln Thr 
    1280                 1285                 1290             


Asp Ser  Val Ile Gln Asn Ser  Glu Asn Ile Lys Ala  Tyr His Ser 
    1295                 1300                 1305             


Gly Glu  Gly His Met Pro Phe  Arg Thr Gly Thr Gly  Asp Ile Ala 
    1310                 1315                 1320             


Thr Cys  Tyr Ser Pro Arg Thr  Ser Thr Glu Ser Phe  Ala Pro Arg 
    1325                 1330                 1335             


Asp Ser  Val Gly Leu Ala Pro  Gln Asp Ser Gln Ala  Ser Asn Ile 
    1340                 1345                 1350             


Leu Val  Met Asp His Met Ile  Met Thr Pro Glu Met  Pro Thr Met 
    1355                 1360                 1365             


Glu Pro  Glu Gly Gly Leu Asp  Asp Ser Gly Glu His  Phe Phe Asp 
    1370                 1375                 1380             


Ala Arg  Glu Ala His Ser Asp  Glu Asn Pro Ser Glu  Gly Asp Gly 
    1385                 1390                 1395             


Ala Val  Asn Lys Glu Glu Lys  Asp Val Asn Leu Arg  Ile Ser Gly 
    1400                 1405                 1410             


Asn Tyr  Leu Ile Leu Asp Gly  Tyr Asp Pro Val Gln  Glu Ser Ser 
    1415                 1420                 1425             


Thr Asp  Glu Glu Val Ala Ser  Ser Leu Thr Leu Gln  Pro Met Thr 
    1430                 1435                 1440             


Gly Ile  Pro Ala Val Glu Ser  Thr His Gln Gln Gln  His Ser Pro 
    1445                 1450                 1455             


Gln Asn  Thr His Ser Asp Gly  Ala Ile Ser Pro Phe  Thr Pro Glu 
    1460                 1465                 1470             


Phe Leu  Val Gln Gln Arg Trp  Gly Ala Met Glu Tyr  Ser Cys Phe 
    1475                 1480                 1485             


Glu Ile  Gln Ser Pro Ser Ser  Cys Ala Asp Ser Gln  Ser Gln Ile 
    1490                 1495                 1500             


Met Glu  Tyr Ile His Lys Ile  Glu Ala Asp Leu Glu  His Leu Lys 
    1505                 1510                 1515             


Lys Val  Glu Glu Ser Tyr Thr  Ile Leu Cys Gln Arg  Leu Ala Gly 
    1520                 1525                 1530             


Ser Ala  Leu Thr Asp Lys His  Ser Asp Lys Ser 
    1535                 1540                 


<210>  1733
<211>  3992
<212>  DNA
<213>  Homosapiens

<400>  1733
aagcaattga ctttctcaga gccacccggc aggctatcgg ggcatcctcg aaaaggccag     60

ggacaggggc gcaggtgcac caagagatct ggcgaggggt acgcttcctc gagacttggg    120

gctctttctc tctgcgctct ccagacactg aactctgagc tgcaaggaca agaacgccac    180

caccttccct actaaggctc tgccacaagc gcatcccagt gaggtgtatc cagctgcagc    240

cgcctccgga gcttcggagc gctcagacct ccctccctcg cgcatctcca gcctaagggt    300

tgtcccacct cgccataaca cggggctctc gcgcgggcat cgaggattct cagcttttgg    360

cgtcccagtc ctgcctctgc tcctgcctgg tggtgtcccc acgcccaggt cctgcggacc    420

cgaccacggc tgaaacgcgc ggctttgccg tctgcgctcc agccttcgcc tggcagagcg    480

cgcagcccac ctagcgtctt ctggctctag gggtgcagag ggcgcatccc gcctcttcct    540

ccgcccccgg gccccgctgt cctcccccac ctgctgacca gcctactcct gcgtgagctg    600

ccagcctttt gccttctgtg cgtaaagcat gtcaggctct gggcgaaaag acttcgatgt    660

gaagcacatt ctgcgactcc gctggaaact cttcagccac ccgtctcctt ccaccggcgg    720

cccggcgggg ggaggctgcc tgcaacagga cggcagtggc agctttgagc actggggacc    780

cagccagagt cgcctgctca aaagccaaga gagaagcggt gtgagcactt tctggaagaa    840

gccttcctcc tcttcctctt catcgtcctc cccgtcctct tcctcctctt ccttcaatcc    900

gctgaatggc accctgcttc cagttgccac gaggctgcag caaggggctc ctgggcaggg    960

cactcagcag ccagccagga ctctcttcta cgtggagtca ctagaggagg aggtggtgcc   1020

aggcatggac tttcctggac cacacgaaaa agggctggtt ctgcaagagc tcaaagtgga   1080

gccagacaac tctagccagg caacaggtga aggatgtgga cacaggctgt catcaaccgg   1140

ccattcaatg acacctcaaa gtgatttgga ctccagtagc tctgaagaat tctatcaagc   1200

tgttcatcat gctgagcaaa ccttcagaaa gatggaaagt tatttgaagc agcagcaact   1260

ttgtgatgtt atcctgattg ttgggaaccg aaagatacct gcacataggc ttgttctgag   1320

ttcagtctcc gactattttg cggccatgtt tacaagtgat gtttgtgaag ccaagcaaga   1380

ggagatcaaa atggaaggca tagaccccaa tgctctctgg gaccttgtcc aatttgcata   1440

tacaggctgc ttggaattaa aagaggacac cattgagaac cttcttgctg cagcgtgcct   1500

tcttcagctt ccacaggtgg tggaagtgtg ctgccacttc ctcatgaagc ttttgcatcc   1560

atctaactgt ttaggaattc gagccttcgc agatgctcaa ggatgcattg agttaatgaa   1620

ggtggcccac agctacacaa tggaaaacat aatggaagtt atcagaaatc aagagttttt   1680

actccttcca gctgaggagc tccataaact actggccagt gatgatgtca atgttcctga   1740

tgaagaaacc atcttccatg cattgatgat gtgggtcaag tatgacatgc agagtagatg   1800

caatgacctg agcatgcttc ttgcctttat aagactgcca ctgcttccac cacagatatt   1860

ggctgaccta gaaaatcatg cattatttaa gaatgatctg gaatgtcaaa agctgattct   1920

agaagcaatg aaataccatc tattgccaga aagaagaact ttaatgcaaa gtccgagaac   1980

taaacccaga aaatctacag tcggaacttt gtatgctgta ggaggaatgg ataacaacaa   2040

aggagctaca actatagaga aatatgatct gagaacaaat ctgtggatcc aggcagggat   2100

gatgaatggc agaaggctgc agtttggtgt ggctgttatt gatgacaaac tctttgtaat   2160

tggaggtcga gatggcttaa agacattgaa cactgttgaa tgttacaatc ccaaaaccaa   2220

gacatggact gtcttaccac caatgtcaac acacagacat ggtctaggtg taacagtact   2280

tgaaggccct atttatgctg tgggaggcca tgatggctgg agctatctga atacagtgga   2340

aaggtgggat ccacagagtc aacaatggac atttgtagcc agtatgtcaa ttgctcggag   2400

cacagttggt gtagcagcat tgaatggcaa gttgtattca gttggaggtc gtgatggaag   2460

ttcctgtttg agttcaatgg aatattatga tcctcataca aataagtgga acatgtgtgc   2520

tcccatgtgt aagaggagag ggggtgtcgg agtggccaca tgtgacggtt ttctttatgc   2580

agtaggaggt catgatgctc ctgcttcaaa tcactgttcc cggctactgg attatgtaga   2640

aagatatgat cccaaaacag acacttggac catggtggct cctttgagta tgcccagaga   2700

tgctgttggg gtctgtctcc ttggtgacag attatatgct gttggtggct atgatggaca   2760

gacatacctc aacactatgg aatcctatga cccacaaact aatgagtgga cacagatggc   2820

ttccttgaat attgggagag caggtgcctg tgtggtagtc atcaagcaac cttgacttat   2880

tgatatttta cttggaaaga ttttacttgc tggagtggtt atttttatat tgaatggcaa   2940

gaatgagaac ttccagagat gaaaactctt caagaacaag gatctctgta gcgttaccta   3000

ctgatgttga aagagttagt agatcaaaca gaatagtagg aaacaagaaa acattaaact   3060

tatacaggaa aaatgtctgg ccatatgtta gttagttcgg gaatggttat tggtaatttg   3120

ttttgtatta tagcatacaa taactagagt taccaaaggc ttgttttttc ttgagcagtt   3180

gaaaggagag accaatattt gtgacatgga tagtttcatg accacaactc attcaatcat   3240

tttatagtct atggcaatat ccaagagatt gccaagagta gaagacagaa tatttcatct   3300

gacagtatct gattggttta ctgtttttct aatcatatgt ggtcataacg ggaagcagaa   3360

ttatgcttta ttcaaacaaa cctgcttctg cctcattttc ctaagctatg agaacaatta   3420

gagaaacaga ttcatgcttg tatcttgcat tcagaaaaca aactgtccta ctaatcaaag   3480

ctgcatatct catcagagat aatggttgaa ttttattgca accatattgg caatctgaaa   3540

ctggcaaaca caaaggattg ttttcactag gcttaccatt ttgctttgct tttttaacac   3600

actgagccaa agatgcagtg taattattgg gcttttgcct tatgttgagt tcagtgtaag   3660

catggaagct agtgattctg aatgatatat atatccattg catgttgaac tcctttagaa   3720

ttttgttctt aaacaaactt agaatttcaa aagaaaacat atgatccatt aagttggagt   3780

gtttatgatt attgctagaa agaaggcaga cttcatattc tcatcgccca tttttcaaac   3840

ttgttacatt gatctgtaca ttattttaag ccacatgttt gtaattgttt aaaacaaagt   3900

ggaaacatta cacaatgtcc ttaataaata ggcccatgta aattttaatt acaattaata   3960

aatgatcaaa aaatttgcat ttaaaaaaaa aa                                 3992


<210>  1734
<211>  748
<212>  PRT
<213>  Homosapiens

<400>  1734

Met Ser Gly Ser Gly Arg Lys Asp Phe Asp Val Lys His Ile Leu Arg 
1               5                   10                  15      


Leu Arg Trp Lys Leu Phe Ser His Pro Ser Pro Ser Thr Gly Gly Pro 
            20                  25                  30          


Ala Gly Gly Gly Cys Leu Gln Gln Asp Gly Ser Gly Ser Phe Glu His 
        35                  40                  45              


Trp Gly Pro Ser Gln Ser Arg Leu Leu Lys Ser Gln Glu Arg Ser Gly 
    50                  55                  60                  


Val Ser Thr Phe Trp Lys Lys Pro Ser Ser Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Ser Ser Ser Ser Ser Ser Phe Asn Pro Leu Asn Gly Thr Leu 
                85                  90                  95      


Leu Pro Val Ala Thr Arg Leu Gln Gln Gly Ala Pro Gly Gln Gly Thr 
            100                 105                 110         


Gln Gln Pro Ala Arg Thr Leu Phe Tyr Val Glu Ser Leu Glu Glu Glu 
        115                 120                 125             


Val Val Pro Gly Met Asp Phe Pro Gly Pro His Glu Lys Gly Leu Val 
    130                 135                 140                 


Leu Gln Glu Leu Lys Val Glu Pro Asp Asn Ser Ser Gln Ala Thr Gly 
145                 150                 155                 160 


Glu Gly Cys Gly His Arg Leu Ser Ser Thr Gly His Ser Met Thr Pro 
                165                 170                 175     


Gln Ser Asp Leu Asp Ser Ser Ser Ser Glu Glu Phe Tyr Gln Ala Val 
            180                 185                 190         


His His Ala Glu Gln Thr Phe Arg Lys Met Glu Ser Tyr Leu Lys Gln 
        195                 200                 205             


Gln Gln Leu Cys Asp Val Ile Leu Ile Val Gly Asn Arg Lys Ile Pro 
    210                 215                 220                 


Ala His Arg Leu Val Leu Ser Ser Val Ser Asp Tyr Phe Ala Ala Met 
225                 230                 235                 240 


Phe Thr Ser Asp Val Cys Glu Ala Lys Gln Glu Glu Ile Lys Met Glu 
                245                 250                 255     


Gly Ile Asp Pro Asn Ala Leu Trp Asp Leu Val Gln Phe Ala Tyr Thr 
            260                 265                 270         


Gly Cys Leu Glu Leu Lys Glu Asp Thr Ile Glu Asn Leu Leu Ala Ala 
        275                 280                 285             


Ala Cys Leu Leu Gln Leu Pro Gln Val Val Glu Val Cys Cys His Phe 
    290                 295                 300                 


Leu Met Lys Leu Leu His Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe 
305                 310                 315                 320 


Ala Asp Ala Gln Gly Cys Ile Glu Leu Met Lys Val Ala His Ser Tyr 
                325                 330                 335     


Thr Met Glu Asn Ile Met Glu Val Ile Arg Asn Gln Glu Phe Leu Leu 
            340                 345                 350         


Leu Pro Ala Glu Glu Leu His Lys Leu Leu Ala Ser Asp Asp Val Asn 
        355                 360                 365             


Val Pro Asp Glu Glu Thr Ile Phe His Ala Leu Met Met Trp Val Lys 
    370                 375                 380                 


Tyr Asp Met Gln Ser Arg Cys Asn Asp Leu Ser Met Leu Leu Ala Phe 
385                 390                 395                 400 


Ile Arg Leu Pro Leu Leu Pro Pro Gln Ile Leu Ala Asp Leu Glu Asn 
                405                 410                 415     


His Ala Leu Phe Lys Asn Asp Leu Glu Cys Gln Lys Leu Ile Leu Glu 
            420                 425                 430         


Ala Met Lys Tyr His Leu Leu Pro Glu Arg Arg Thr Leu Met Gln Ser 
        435                 440                 445             


Pro Arg Thr Lys Pro Arg Lys Ser Thr Val Gly Thr Leu Tyr Ala Val 
    450                 455                 460                 


Gly Gly Met Asp Asn Asn Lys Gly Ala Thr Thr Ile Glu Lys Tyr Asp 
465                 470                 475                 480 


Leu Arg Thr Asn Leu Trp Ile Gln Ala Gly Met Met Asn Gly Arg Arg 
                485                 490                 495     


Leu Gln Phe Gly Val Ala Val Ile Asp Asp Lys Leu Phe Val Ile Gly 
            500                 505                 510         


Gly Arg Asp Gly Leu Lys Thr Leu Asn Thr Val Glu Cys Tyr Asn Pro 
        515                 520                 525             


Lys Thr Lys Thr Trp Thr Val Leu Pro Pro Met Ser Thr His Arg His 
    530                 535                 540                 


Gly Leu Gly Val Thr Val Leu Glu Gly Pro Ile Tyr Ala Val Gly Gly 
545                 550                 555                 560 


His Asp Gly Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp Asp Pro Gln 
                565                 570                 575     


Ser Gln Gln Trp Thr Phe Val Ala Ser Met Ser Ile Ala Arg Ser Thr 
            580                 585                 590         


Val Gly Val Ala Ala Leu Asn Gly Lys Leu Tyr Ser Val Gly Gly Arg 
        595                 600                 605             


Asp Gly Ser Ser Cys Leu Ser Ser Met Glu Tyr Tyr Asp Pro His Thr 
    610                 615                 620                 


Asn Lys Trp Asn Met Cys Ala Pro Met Cys Lys Arg Arg Gly Gly Val 
625                 630                 635                 640 


Gly Val Ala Thr Cys Asp Gly Phe Leu Tyr Ala Val Gly Gly His Asp 
                645                 650                 655     


Ala Pro Ala Ser Asn His Cys Ser Arg Leu Leu Asp Tyr Val Glu Arg 
            660                 665                 670         


Tyr Asp Pro Lys Thr Asp Thr Trp Thr Met Val Ala Pro Leu Ser Met 
        675                 680                 685             


Pro Arg Asp Ala Val Gly Val Cys Leu Leu Gly Asp Arg Leu Tyr Ala 
    690                 695                 700                 


Val Gly Gly Tyr Asp Gly Gln Thr Tyr Leu Asn Thr Met Glu Ser Tyr 
705                 710                 715                 720 


Asp Pro Gln Thr Asn Glu Trp Thr Gln Met Ala Ser Leu Asn Ile Gly 
                725                 730                 735     


Arg Ala Gly Ala Cys Val Val Val Ile Lys Gln Pro 
            740                 745             


<210>  1735
<211>  1897
<212>  DNA
<213>  Homosapiens

<400>  1735
acttcctctc caggaatccg cggagggagc gcaggctcga agagctcctg gacgcagagg     60

ccctgccctt gccagacggc gcagacatgt cagaacaaag taaggatctg agcgacccta    120

actttgcagc cgaggccccc aactccgagg tgcacagcag ccctggggtt tcggaggggg    180

ttcctccgtc cgcgaccctg gcagagccgc agagccctcc tctaggcccg acggccgctc    240

cgcaggccgc gccgcctccc caggccccga acgacgaggg cgacccgaag gccctgcagc    300

aggctgcgga ggagggccgc gcccaccagg ccccgagcgc ggcccagccg ggcccggcac    360

cgccagcccc ggcgcagctg gtgcagaagg cgcacgagct catgtggtac gtgctggtca    420

aggaccagaa gaagatgatc atctggtttc cagacatggt gaaagatgtc atcggcagct    480

acaagaagtg gtgcaggagc atcctccggc gcaccagcct catcctcgcc cgggtgttcg    540

ggctgcacct gaggctaacc agcctgcaca ccatggagtt tgcgctggtc aaagcgctgg    600

agcccgagga gctggacagg gtggcgctga gcaaccgcat gcccatgaca ggcctcctgc    660

tcatgatcct gagcctcatc tacgtgaagg gccgcggcgc cagagagagc gccgtctgga    720

acgtgctgcg catcctgggg ctgcggccct ggaagaagca ctccaccttc ggggacgtgc    780

ggaagctcat cactgaggag ttcgtccaaa tgaattacct gaagtaccag cgcgtcccat    840

acgtggagcc gcccgaatac gagttctttt ggggctcccg ggccagccgc gaaatcacca    900

agatgcaaat catggagttc ctggccaggg tctttaagaa agacccccag gcctggccct    960

cccgatacag agaagctctg gaggaggcca gagctctgcg ggaggctaat cccactgccc   1020

actaccctcg cagcagtgtc tctgaggact agcaaagtct ggaggcagat gaatggtttc   1080

tgaccctcac cagggctgtg gaagggtggg ggtgggtcat tatagtattc aggatttaca   1140

gtgcagtatt cacgtgtaac ttttaagttt tcagtacagt gcttttatac ctttaatgca   1200

atgttgtatt catttgggta ctattgtgta gtatttagga tgtatgcatg tttgtttata   1260

tgtaagcttg gttggtgctt tcgcttttgt gctacctttc ttggattttt gtaccagaga   1320

tgtgctaaac tgatgaaata cattgagaaa gtttccatct tattctttta tatgggactg   1380

atgatgtgtg ttggggtaga ctgctcctgc agagtttgga agaagtcacc agcaaagccg   1440

gcctaaccaa gaaaagtcaa ggcccttcat gaccttgctg ggcacagaaa acaccctcgt   1500

ggagtacact aatttgaact ggactggtct cagtgtgagc acttggcaca ctttactaaa   1560

cacatataca accccaccgt gagtcaactt taaagtaaac attaaagatt cttgtgatac   1620

aatcattttt ggaaaagtgt actttatcat tttaacaaag cagtatggtt gggaatgaga   1680

caattctcta ttttacagtg tatacagata caactatttc ccctaatagg gtgggaaaaa   1740

tcgctactca tgattactcc taaatttgtg aagtttatag ttctattgtc tttaaatgta   1800

actcatgttt atttcaaaaa cattcacaaa tatagaaaag tatacaaaac aaaacagtaa   1860

gattgtctgt aatcacatca tatgggaata aaaaaca                            1897


<210>  1736
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  1736

Met Ser Glu Gln Ser Lys Asp Leu Ser Asp Pro Asn Phe Ala Ala Glu 
1               5                   10                  15      


Ala Pro Asn Ser Glu Val His Ser Ser Pro Gly Val Ser Glu Gly Val 
            20                  25                  30          


Pro Pro Ser Ala Thr Leu Ala Glu Pro Gln Ser Pro Pro Leu Gly Pro 
        35                  40                  45              


Thr Ala Ala Pro Gln Ala Ala Pro Pro Pro Gln Ala Pro Asn Asp Glu 
    50                  55                  60                  


Gly Asp Pro Lys Ala Leu Gln Gln Ala Ala Glu Glu Gly Arg Ala His 
65                  70                  75                  80  


Gln Ala Pro Ser Ala Ala Gln Pro Gly Pro Ala Pro Pro Ala Pro Ala 
                85                  90                  95      


Gln Leu Val Gln Lys Ala His Glu Leu Met Trp Tyr Val Leu Val Lys 
            100                 105                 110         


Asp Gln Lys Lys Met Ile Ile Trp Phe Pro Asp Met Val Lys Asp Val 
        115                 120                 125             


Ile Gly Ser Tyr Lys Lys Trp Cys Arg Ser Ile Leu Arg Arg Thr Ser 
    130                 135                 140                 


Leu Ile Leu Ala Arg Val Phe Gly Leu His Leu Arg Leu Thr Ser Leu 
145                 150                 155                 160 


His Thr Met Glu Phe Ala Leu Val Lys Ala Leu Glu Pro Glu Glu Leu 
                165                 170                 175     


Asp Arg Val Ala Leu Ser Asn Arg Met Pro Met Thr Gly Leu Leu Leu 
            180                 185                 190         


Met Ile Leu Ser Leu Ile Tyr Val Lys Gly Arg Gly Ala Arg Glu Ser 
        195                 200                 205             


Ala Val Trp Asn Val Leu Arg Ile Leu Gly Leu Arg Pro Trp Lys Lys 
    210                 215                 220                 


His Ser Thr Phe Gly Asp Val Arg Lys Leu Ile Thr Glu Glu Phe Val 
225                 230                 235                 240 


Gln Met Asn Tyr Leu Lys Tyr Gln Arg Val Pro Tyr Val Glu Pro Pro 
                245                 250                 255     


Glu Tyr Glu Phe Phe Trp Gly Ser Arg Ala Ser Arg Glu Ile Thr Lys 
            260                 265                 270         


Met Gln Ile Met Glu Phe Leu Ala Arg Val Phe Lys Lys Asp Pro Gln 
        275                 280                 285             


Ala Trp Pro Ser Arg Tyr Arg Glu Ala Leu Glu Glu Ala Arg Ala Leu 
    290                 295                 300                 


Arg Glu Ala Asn Pro Thr Ala His Tyr Pro Arg Ser Ser Val Ser Glu 
305                 310                 315                 320 


Asp 
    


<210>  1737
<211>  3103
<212>  DNA
<213>  Homosapiens

<400>  1737
gtgggtgcaa gatggcgcaa gcggcgctcc ccctgcgccc cccgcgctgc tgagcaggca     60

tgcggcccca gtcccccacc gcctgggctc ggccccggcc ggagccccag ccccggcccc    120

ggcgccggcc ccgcgggacg ctgtgagccg cgagaggccc gggagccgcg cgtcgccgag    180

ccgagctgac cgagagcccc atggctgtgc agcgcgccgc gtctccgcgc cgcccgcccg    240

ccccgctctg gccccggctc ctgctgccgc tgctgttgct gctgctgccc gcgccgagcg    300

agggtcttgg ccactctgcc gaactggcat ttgctgtgga gccaagtgat gatgttgccg    360

tccccgggca gcctatagtg ctggactgca gggtggaggg gacccctcca gtgcgaatca    420

cctggaggaa gaatggggta gagctgccag agagtaccca ctccaccttg ctggccaatg    480

ggtccttgat gatccgtcac ttcaggctgg agccgggagg cagcccttcg gatgaaggtg    540

actatgagtg tgtggcccag aaccgctttg ggctggtggt cagccggaag gctcgcatcc    600

aagctgcaac catgtcggac ttccacgtgc atccccaggc caccgtgggt gaggagggtg    660

gtgtggcccg cttccagtgc caaatccatg ggcttcccaa acccctgatc acttgggaga    720

agaacagagt cccaattgac acggacaatg agaggtacac attgctgccc aagggggtcc    780

tgcagatcac aggacttcga gctgaggacg gtggcatctt ccactgtgtg gcctcaaaca    840

tcgccagtat ccggatcagc cacggggcca ggctcactgt gtcaggctcg ggctctgggg    900

cctacaagga gccagccatc ctcgtggggc ctgagaacct caccctgaca gtgcaccaga    960

ccgcggtgct tgagtgtgtc gccacgggca acccgcgccc cattgtgtcc tggagccgcc   1020

tggatggtcg ccctatcggg gtggagggca tccaggtgct gggcacagga aacctcatca   1080

tctcagacgt gacggtccag cactctggcg tctacgtctg tgcagccaac agacctggca   1140

cccgggtgag gagaacggca cagggccggc tggtggtgca agccccagct gagtttgtgc   1200

agcatcccca gtccatctcc aggccagctg ggaccacagc catgttcacc tgccaagccc   1260

agggtgagcc accgcctcat gtcacgtggc tgaaaaatgg acaggtgctg gggccaggag   1320

gccacgtcag gctcaagaat aacaacagca cactgaccat ttctggaatc ggtcctgagg   1380

atgaagccat ttatcagtgt gtggccgaga acagtgcggg ctcatcacag gccagtgcca   1440

ggctgaccgt actgtgggct gaggggctcc ccgggcctcc ccgcaatgtg cgggcagtct   1500

ctgtgtcttc cactgaggtg cgtgtgtcct ggagtgagcc gctggccaac accaaggaga   1560

tcatcggcta cgtcctgcac atcaggaagg ctgctgaccc accggagctg gagtatcagg   1620

aggcagtcag caagagcacc tttcagcacc tggtcagcga cctggagccc tccacagcct   1680

acagtttcta catcaaggcc tacacaccaa ggggggccag ctcagcctct gtgcccaccc   1740

tagctagcac cctgggtgaa gcccctgccc cacccccact gtcagtgcga gtcctgggca   1800

gctcctcctt gcagctgctg tgggagcctt ggccccggct ggcccagcac gagggcggct   1860

tcaagctgtt ttaccgccca gcaagcaaga cctccttcac cggccccatc ctgctgcctg   1920

gaaccgtctc ctcctacaac ctcagccagc tcgaccccac tgcagtgtat gaggtgaagc   1980

tgctcgccta caaccagcat ggagatggca atgccacagt ccgctttgtg tctttgaggg   2040

gagcatctga gaggacagcc ttgagcccac catgtgactg ccggaaggag gaggccgcca   2100

accagacgtc caccacaggc atcgtcatcg gcatccacat cggggtcact tgcatcatct   2160

tctgtgtcct cttcctcctg ttcggccaaa ggggcagggt cctcctgtgt aaagatgtgg   2220

aaaaccagct gtcccctcca cagggtcccc ggagccagag ggaccctggc attctggccc   2280

taaatggggc gagacgggga cagcggggcc agctgggccg agacgagaaa cgtgtggata   2340

tgaaggagct ggagcagctg ttccccccgg ccagcgcagc agggcagccg gaccccagac   2400

ccacacagga tcctgcagcc cccgctccgt gtgaggagac ccagctctcc ttgctgccac   2460

ttcaggggtg cggcctgatg gaggggaaga cgacggaggc gaagaccaca gaggccacgg   2520

ctccctgcgc cggcctggcg gctgccccac cacccccaga tggaggccct ggcctcctca   2580

gtgaaggcca ggcttccagg cctgcagcgg cccgggttac ccagccagct cactcggaac   2640

agtagccagt gtctggcagg ctccagaggg tggacggagc ggggcccatt ctcaggtcaa   2700

aagcaagatt tctactgtca tgtgggattt ggatggtcct gggggctccc cagtatttct   2760

atcctgactg cctcttgggt tgtcaaaacc caaggcagcc ttgacaggga ccccccggcc   2820

ctaacaccca tcaggagttg gagcagttcc tgcaggagcc tgttccttcc ctgggctgac   2880

gcccccttgc ctctgcctgg tacccacatg acttggaact gaactaacat ttttctttaa   2940

aaagcaaaac ttaaaaaaaa aaaaaaagag gagagagata gaggaaggtg aattagactc   3000

caaaagatga ccctgctgta gctgggccct gacactgtca ccctccaccg actttgtttt   3060

ctcaggatgg atttttgctg ttttggctct cagcacctac ctc                     3103


<210>  1738
<211>  814
<212>  PRT
<213>  Homosapiens

<400>  1738

Met Ala Val Gln Arg Ala Ala Ser Pro Arg Arg Pro Pro Ala Pro Leu 
1               5                   10                  15      


Trp Pro Arg Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Pro Ala Pro 
            20                  25                  30          


Ser Glu Gly Leu Gly His Ser Ala Glu Leu Ala Phe Ala Val Glu Pro 
        35                  40                  45              


Ser Asp Asp Val Ala Val Pro Gly Gln Pro Ile Val Leu Asp Cys Arg 
    50                  55                  60                  


Val Glu Gly Thr Pro Pro Val Arg Ile Thr Trp Arg Lys Asn Gly Val 
65                  70                  75                  80  


Glu Leu Pro Glu Ser Thr His Ser Thr Leu Leu Ala Asn Gly Ser Leu 
                85                  90                  95      


Met Ile Arg His Phe Arg Leu Glu Pro Gly Gly Ser Pro Ser Asp Glu 
            100                 105                 110         


Gly Asp Tyr Glu Cys Val Ala Gln Asn Arg Phe Gly Leu Val Val Ser 
        115                 120                 125             


Arg Lys Ala Arg Ile Gln Ala Ala Thr Met Ser Asp Phe His Val His 
    130                 135                 140                 


Pro Gln Ala Thr Val Gly Glu Glu Gly Gly Val Ala Arg Phe Gln Cys 
145                 150                 155                 160 


Gln Ile His Gly Leu Pro Lys Pro Leu Ile Thr Trp Glu Lys Asn Arg 
                165                 170                 175     


Val Pro Ile Asp Thr Asp Asn Glu Arg Tyr Thr Leu Leu Pro Lys Gly 
            180                 185                 190         


Val Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Gly Gly Ile Phe His 
        195                 200                 205             


Cys Val Ala Ser Asn Ile Ala Ser Ile Arg Ile Ser His Gly Ala Arg 
    210                 215                 220                 


Leu Thr Val Ser Gly Ser Gly Ser Gly Ala Tyr Lys Glu Pro Ala Ile 
225                 230                 235                 240 


Leu Val Gly Pro Glu Asn Leu Thr Leu Thr Val His Gln Thr Ala Val 
                245                 250                 255     


Leu Glu Cys Val Ala Thr Gly Asn Pro Arg Pro Ile Val Ser Trp Ser 
            260                 265                 270         


Arg Leu Asp Gly Arg Pro Ile Gly Val Glu Gly Ile Gln Val Leu Gly 
        275                 280                 285             


Thr Gly Asn Leu Ile Ile Ser Asp Val Thr Val Gln His Ser Gly Val 
    290                 295                 300                 


Tyr Val Cys Ala Ala Asn Arg Pro Gly Thr Arg Val Arg Arg Thr Ala 
305                 310                 315                 320 


Gln Gly Arg Leu Val Val Gln Ala Pro Ala Glu Phe Val Gln His Pro 
                325                 330                 335     


Gln Ser Ile Ser Arg Pro Ala Gly Thr Thr Ala Met Phe Thr Cys Gln 
            340                 345                 350         


Ala Gln Gly Glu Pro Pro Pro His Val Thr Trp Leu Lys Asn Gly Gln 
        355                 360                 365             


Val Leu Gly Pro Gly Gly His Val Arg Leu Lys Asn Asn Asn Ser Thr 
    370                 375                 380                 


Leu Thr Ile Ser Gly Ile Gly Pro Glu Asp Glu Ala Ile Tyr Gln Cys 
385                 390                 395                 400 


Val Ala Glu Asn Ser Ala Gly Ser Ser Gln Ala Ser Ala Arg Leu Thr 
                405                 410                 415     


Val Leu Trp Ala Glu Gly Leu Pro Gly Pro Pro Arg Asn Val Arg Ala 
            420                 425                 430         


Val Ser Val Ser Ser Thr Glu Val Arg Val Ser Trp Ser Glu Pro Leu 
        435                 440                 445             


Ala Asn Thr Lys Glu Ile Ile Gly Tyr Val Leu His Ile Arg Lys Ala 
    450                 455                 460                 


Ala Asp Pro Pro Glu Leu Glu Tyr Gln Glu Ala Val Ser Lys Ser Thr 
465                 470                 475                 480 


Phe Gln His Leu Val Ser Asp Leu Glu Pro Ser Thr Ala Tyr Ser Phe 
                485                 490                 495     


Tyr Ile Lys Ala Tyr Thr Pro Arg Gly Ala Ser Ser Ala Ser Val Pro 
            500                 505                 510         


Thr Leu Ala Ser Thr Leu Gly Glu Ala Pro Ala Pro Pro Pro Leu Ser 
        515                 520                 525             


Val Arg Val Leu Gly Ser Ser Ser Leu Gln Leu Leu Trp Glu Pro Trp 
    530                 535                 540                 


Pro Arg Leu Ala Gln His Glu Gly Gly Phe Lys Leu Phe Tyr Arg Pro 
545                 550                 555                 560 


Ala Ser Lys Thr Ser Phe Thr Gly Pro Ile Leu Leu Pro Gly Thr Val 
                565                 570                 575     


Ser Ser Tyr Asn Leu Ser Gln Leu Asp Pro Thr Ala Val Tyr Glu Val 
            580                 585                 590         


Lys Leu Leu Ala Tyr Asn Gln His Gly Asp Gly Asn Ala Thr Val Arg 
        595                 600                 605             


Phe Val Ser Leu Arg Gly Ala Ser Glu Arg Thr Ala Leu Ser Pro Pro 
    610                 615                 620                 


Cys Asp Cys Arg Lys Glu Glu Ala Ala Asn Gln Thr Ser Thr Thr Gly 
625                 630                 635                 640 


Ile Val Ile Gly Ile His Ile Gly Val Thr Cys Ile Ile Phe Cys Val 
                645                 650                 655     


Leu Phe Leu Leu Phe Gly Gln Arg Gly Arg Val Leu Leu Cys Lys Asp 
            660                 665                 670         


Val Glu Asn Gln Leu Ser Pro Pro Gln Gly Pro Arg Ser Gln Arg Asp 
        675                 680                 685             


Pro Gly Ile Leu Ala Leu Asn Gly Ala Arg Arg Gly Gln Arg Gly Gln 
    690                 695                 700                 


Leu Gly Arg Asp Glu Lys Arg Val Asp Met Lys Glu Leu Glu Gln Leu 
705                 710                 715                 720 


Phe Pro Pro Ala Ser Ala Ala Gly Gln Pro Asp Pro Arg Pro Thr Gln 
                725                 730                 735     


Asp Pro Ala Ala Pro Ala Pro Cys Glu Glu Thr Gln Leu Ser Leu Leu 
            740                 745                 750         


Pro Leu Gln Gly Cys Gly Leu Met Glu Gly Lys Thr Thr Glu Ala Lys 
        755                 760                 765             


Thr Thr Glu Ala Thr Ala Pro Cys Ala Gly Leu Ala Ala Ala Pro Pro 
    770                 775                 780                 


Pro Pro Asp Gly Gly Pro Gly Leu Leu Ser Glu Gly Gln Ala Ser Arg 
785                 790                 795                 800 


Pro Ala Ala Ala Arg Val Thr Gln Pro Ala His Ser Glu Gln 
                805                 810                 


<210>  1739
<211>  6485
<212>  DNA
<213>  Homosapiens

<400>  1739
ctcgcccaag atggcgatgg aggggcgggt gaggcggcag cggccctggc ccccgcgccg     60

gccccagctc gggcccgggc ccccgaggcc gcgcccccgc ccgcggcgcc gcgcctcccc    120

gggccactga cgcccggcgc gctctccccc cgcggcggcg gccgaagcac ggggaggcgg    180

cggcggcggc ggcggcccga gcccagcccc atggcgcggg gggacgccgg ccgcggccgt    240

gggctcctcg cgttgacctt ctgcctgttg gccgcgcgcg gggagctgct gttgccccag    300

gagacgactg tggagctgag ctgtggagtg gggccactgc aagtgatcct gggcccagag    360

caggctgcag tgctaaactg tagcctgggg gctgctgccg ctggaccccc caccagggtg    420

acctggagca aggatgggga caccctgctg gagcacgacc acttacacct gctgcccaat    480

ggttccctgt ggctgtccca gccactagca cccaatggca gtgacgagtc agtccctgag    540

gctgtggggg tcattgaagg caactattcg tgcctagccc acggccccct cggagtgctg    600

gccagccaga ctgctgtcgt caagcttgcc acactcgcag acttctctct gcacccggag    660

tctcagacgg tggaggagaa cgggacagct cgctttgagt gccacattga agggctgcca    720

gctcccatca ttacttggga gaaggaccag gtgacattgc ctgaggagcc tcggctcatc    780

gtgcttccca acggcgtcct tcagatcctg gatgttcagg agagtgatgc aggcccctac    840

cgctgcgtgg ccaccaactc agctcgccag cacttcagcc aggaggccct actcagtgtg    900

gcccacagag ggtccctggc gtccaccagg gggcaggacg tggtcattgt ggcagcccca    960

gagaacacca cagtggtgtc tggccagagt gtggtgatgg aatgtgtggc ctcagctgac   1020

cccacccctt ttgtgtcctg ggtccgacaa gacgggaagc ccatctccac agatgtcatc   1080

gtcctgggcc gcaccaacct actaattgcc aacgcgcagc cctggcactc cggcgtctat   1140

gtctgccgcg ccaacaagcc ccgcacgcgc gacttcgcca ctgcagccgc tgagctccgt   1200

gtgctggcgg ctcccgccat cactcaggcg cccgaggcgc tgtcgcggac gcgggcgagc   1260

acagcgcgct tcgtgtgccg cgcgtcgggg gagccgcggc cagcgctgcg ctggctgcac   1320

aacggggcgc cgctgcggcc caacgggcgc gtcaaggtcc agggcggcgg tggcagcctg   1380

gtcatcacac agatcggcct gcaggacgcc ggctactacc agtgcgtggc tgagaacagc   1440

gcgggaatgg cgtgcgctgc cgcgtcgctg gccgtggtgg tgcgcgaggg gctgcccagc   1500

gcccccacgc gggtcactgc tacgccactg agcagctccg ctgtgttggt ggcctgggag   1560

cggcccgaga tgcacagcga gcagatcatc ggcttctctc tccactacca gaaggcacgg   1620

ggcatggaca atgtggaata ccagtttgca gtgaacaacg acaccacaga actacaggtt   1680

cgggacctgg aacccaacac agattatgag ttctacgtgg tggcctactc ccagctggga   1740

gccagccgca cctccacccc agcactggtg cacacactgg atgatgtccc cagtgcagca   1800

ccccagctct ccctgtccag ccccaaccct tcggacatca gggtggcgtg gctgcccctg   1860

ccccccagcc tgagcaatgg gcaggtggtg aagtacaaga tagaatacgg tttgggaaag   1920

gaagatcaga ttttctctac tgaggtgcga ggaaatgaga cacagcttat gctgaactcg   1980

cttcagccaa acaaggtgta tcgagtacgg atttcggctg gtacagcagc cggcttcggg   2040

gccccctccc agtggatgca tcacaggacg cccagtatgc acaaccagag ccatgtccct   2100

tttgcccctg cagagttgaa ggtgcaggca aagatggagt ccctggtcgt gtcatggcag   2160

ccaccccctc accccaccca gatctctggc tacaaactat attggcggga ggtgggggct   2220

gaggaggagg ccaatggcga tcgcctgcca gggggccgtg gagaccaggc ttgggatgtg   2280

gggcctgtcc ggctcaagaa gaaagtgaag cagtatgagc tgacccagct agtccctggc   2340

cggctgtacg aggtgaagct cgtggctttc aacaaacatg aggatggcta tgcagcagtg   2400

tggaagggca agacggagaa ggcgccggca ccagacatgc ctatccagag gggaccaccc   2460

ctgcctccag cccacgtcca tgcggaatca aacagctcca catccatctg gcttcggtgg   2520

aaaaagccag atttcaccac agtcaagatt gtcaactaca ctgtgcgctt cagcccctgg   2580

gggctcagga atgcctccct ggtcacctat tacaccagtt ctggagaaga catcctcatt   2640

ggcggcttga agccattcac caaatacgag tttgcagtgc agtctcacgg cgtggacatg   2700

gatgggcctt tcggctctgt ggtggagcgc tccaccctgc ctgaccggcc ctccacaccc   2760

ccatccgacc tgcgactgag ccccctgaca ccgtccacgg ttcggctgca ctggtgcccc   2820

cccacagagc ccaacgggga gatcgtggag tatctgatcc tgtacagcag caaccacacg   2880

cagcctgagc accagtggac cttgctcacc acgcagggaa acatcttcag tgctgaggtc   2940

catggcctgg agagcgacac tcggtacttc ttcaagatgg gggcgcgcac agaggtggga   3000

cctgggcctt tctcccgcct gcaggatgtg atcacgctcc aggagaagct gtcagactcg   3060

ctggacatgc actcagtcac gggcatcatc gtgggtgtct gcctgggcct cctctgcctc   3120

ctggcctgca tgtgtgctgg cctgcgccgc agcccccaca gggaatccct cccaggcctg   3180

tcctccaccg ccacccccgg gaatcccgcg ctgtactcca gagctcggct tggccccccc   3240

agccccccag ctgcccatga attggagtcc cttgtgcacc cccatcccca ggactggtcc   3300

ccgccaccct cagacgtgga ggacagggct gaagtgcaca gccttatggg tggcggtgtt   3360

tctgaaggcc ggagtcactc caaaagaaag atctcctggg ctcaaccaag cgggctgagc   3420

tgggctggtt cctgggcagg ctgtgagctg ccccaggcag gcccccggcc ggctctgacc   3480

cgggccctgc tgccccctgc tggaactggg cagacgctgt tgctgcaggc tctggtgtac   3540

gacgccataa agggcaatgg gaggaagaag tcacccccag cctgcaggaa ccaggtggag   3600

gctgaagtca ttgtccactc tgactttagt gcatctaacg ggaaccctga cctccatctc   3660

caagacctgg agcctgagga ccccctgcct ccagaggctc ctgatctcat ctcgggtgtt   3720

ggggatccag ggcagggggc agcctggctg gacagggagt tgggagggtg tgagctggca   3780

gcccccgggc cagacagact tacctgcttg ccagaggcag ccagtgcttc ctgctcctac   3840

ccggacctcc agccaggcga ggtgctagag gagacccctg gagatagctg ccagctcaaa   3900

tccccctgcc ctctaggagc cagcccaggc ctgcccagat ccccggtctc ctcctctgcc   3960

tagctcttcc cagaggatgt ggtttggggc aggcaggtat ggatcacata ggatgcgata   4020

cctgtggccg tgtatgtcca catgtgtgcc tgtagataca tcatcaagcc ctttggagct   4080

tcctaagttg ctttggctga ggggagagga aaacatggat tattcactcc ccccatactc   4140

tttgtgatac acatgtgaca tgtgaaagac atacgagaca tagctacatg tgatgtgcac   4200

atgtgtgaag tgcatgtatg cgtactggtt gttgagctgg gaaaccgtgg cccaggcagt   4260

ggtcactaca gcctgattgg tcctccaggt cagaacggtg ccccacagtg gtcagtcccc   4320

agccctgtgg gcccccacct ccatcgccca gccttttatt acacactctg agagtgtctc   4380

caatgcctgt ctgacaaaga cagtcccagc ccattctcct gtctggctgg gttgggtgca   4440

agcaggctct gaatgcctgg catttcagct gcatcacctc ccagctcctt attgcccaaa   4500

tagagagggt ggccctggct cccctccgag caactctgca tttaattttg taatctggga   4560

agtgcctggt tttgaaaatc cgctttctct cactcttccc ctccttcctt gcccctggct   4620

gctctagtgt tctgtctccc agtcacctcg ctctcccagc accagtgccc ttctcctgct   4680

cccagatact ctttcctttc ctctctcctg ttttccttcc tctgctatct ctcacacctc   4740

tcccagacta tgtcatcttg ttctcctgcc tgggttcaaa ctctgcatcc ttctctaaca   4800

acgtgactac ctcatgtctg cttcaaggcc cccgtgccct tcctgtatcc gcggctgccg   4860

cgcactcgcc tgccatcctc ctgcctcctc ttcactcagt gcttctgctt gccctgcccc   4920

aggcagccca cccacgccca gtgcgggtgt ggagaagatc ttctggcttc cctgcatctt   4980

gcctttggga ttgggatcca agggttctcc atggatggat ccaagtcata gaggggaatg   5040

tttgagacag ggaagggggc tgtgatccag aggctcagaa taaaaagatg ccctcccttc   5100

tatgcagggg ggcaagttta ctggatggag atgatttggg cctctcttcc agaagaagct   5160

aaaggaagag aaggggagtg agagttcagg gaggcccttc ccaccctgtg aggcttgact   5220

tgatctggat tggggatgac aggaatctca ccctctgggg tgctggcaag gaggtctttg   5280

cacaggaaaa ggggtagctc atttcagttt gttttttctt taaattgaat cctcaagtca   5340

ttttctgttc acctgccgca cagggacaag cttgacttct attttctgtg tagtgaaaac   5400

aatgtcattt atttggtttt tcacctcagc cctctcatag gagcatagaa tgttagggtc   5460

tttactccct aatgatgtct gattggcaca tcaagagtta actctgcctt ctgggccaaa   5520

ttcgaaataa ccagtccatt tttccttttt tttttttttt tttttaaatg gtggaatgtc   5580

tctcagcaca gttgcggctt cctcaaaccc tgaaagcatc tgtgtttatt atactcgggt   5640

gtcactcact gttgatgtct gcacctacgt ttccacctcc tccccctcct tcagccagcc   5700

tatgataaca ctaaagatta ttaatgttgg ttttgtatct cgttaaagac agaattgtca   5760

cttgtagtat ttctgtagca ttcagcgctg ctgtggctaa caccactgtg tatgtttcat   5820

cattgctctg aaggtcaaaa gcctcatttt attttgctgg tttgattttt tttttttaaa   5880

gaagaaaaaa aaactgccct gaattaaatg gctgttttaa cagtaggctc ttagcattat   5940

accacatagt catttttcat gttcttgttt aacaggcact gaggttctgg tttaaattaa   6000

atagctgcaa atgagacaat ttataaccca ttaggttggg tggaaaattg tttctcaaaa   6060

gcaaataagt aataaatctg gtatctgcct ataactcaca gttgataaga aagtggccat   6120

ttctcactag cactatatat gatttgggct ctgggtaatt tggaagtgtt aggtttgtgt   6180

ctttgtagca gtatttttat tagaaaagaa tctattggcc ttttacaggg tattaatccc   6240

tttgtcacct accattgatg ccttaagttt tctgagtctc aattaaaaat cttccttttc   6300

ttgatgcatg acaagtgtaa tcagtacttg ctcatttatt tgtctgtatt tagtttatgc   6360

tgtactattt aattatcctt ccagcgtttt ttttttctcc ttacaaatat gatactcttt   6420

agtgttaagc taaggcattg attcatgtat ctgtccttat aatgaattaa taaactattt   6480

tccag                                                               6485


<210>  1740
<211>  1250
<212>  PRT
<213>  Homosapiens

<400>  1740

Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr 
1               5                   10                  15      


Phe Cys Leu Leu Ala Ala Arg Gly Glu Leu Leu Leu Pro Gln Glu Thr 
            20                  25                  30          


Thr Val Glu Leu Ser Cys Gly Val Gly Pro Leu Gln Val Ile Leu Gly 
        35                  40                  45              


Pro Glu Gln Ala Ala Val Leu Asn Cys Ser Leu Gly Ala Ala Ala Ala 
    50                  55                  60                  


Gly Pro Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Leu Leu 
65                  70                  75                  80  


Glu His Asp His Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser 
                85                  90                  95      


Gln Pro Leu Ala Pro Asn Gly Ser Asp Glu Ser Val Pro Glu Ala Val 
            100                 105                 110         


Gly Val Ile Glu Gly Asn Tyr Ser Cys Leu Ala His Gly Pro Leu Gly 
        115                 120                 125             


Val Leu Ala Ser Gln Thr Ala Val Val Lys Leu Ala Thr Leu Ala Asp 
    130                 135                 140                 


Phe Ser Leu His Pro Glu Ser Gln Thr Val Glu Glu Asn Gly Thr Ala 
145                 150                 155                 160 


Arg Phe Glu Cys His Ile Glu Gly Leu Pro Ala Pro Ile Ile Thr Trp 
                165                 170                 175     


Glu Lys Asp Gln Val Thr Leu Pro Glu Glu Pro Arg Leu Ile Val Leu 
            180                 185                 190         


Pro Asn Gly Val Leu Gln Ile Leu Asp Val Gln Glu Ser Asp Ala Gly 
        195                 200                 205             


Pro Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln His Phe Ser Gln 
    210                 215                 220                 


Glu Ala Leu Leu Ser Val Ala His Arg Gly Ser Leu Ala Ser Thr Arg 
225                 230                 235                 240 


Gly Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val 
                245                 250                 255     


Ser Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr 
            260                 265                 270         


Pro Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp 
        275                 280                 285             


Val Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Asn Ala Gln Pro 
    290                 295                 300                 


Trp His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg 
305                 310                 315                 320 


Asp Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala 
                325                 330                 335     


Ile Thr Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala 
            340                 345                 350         


Arg Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu Arg Trp 
        355                 360                 365             


Leu His Asn Gly Ala Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln 
    370                 375                 380                 


Gly Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala 
385                 390                 395                 400 


Gly Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Met Ala Cys Ala 
                405                 410                 415     


Ala Ala Ser Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro 
            420                 425                 430         


Thr Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ala Val Leu Val Ala 
        435                 440                 445             


Trp Glu Arg Pro Glu Met His Ser Glu Gln Ile Ile Gly Phe Ser Leu 
    450                 455                 460                 


His Tyr Gln Lys Ala Arg Gly Met Asp Asn Val Glu Tyr Gln Phe Ala 
465                 470                 475                 480 


Val Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn 
                485                 490                 495     


Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser 
            500                 505                 510         


Arg Thr Ser Thr Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser 
        515                 520                 525             


Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg 
    530                 535                 540                 


Val Ala Trp Leu Pro Leu Pro Pro Ser Leu Ser Asn Gly Gln Val Val 
545                 550                 555                 560 


Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Ile Phe Ser 
                565                 570                 575     


Thr Glu Val Arg Gly Asn Glu Thr Gln Leu Met Leu Asn Ser Leu Gln 
            580                 585                 590         


Pro Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Ala Ala Gly 
        595                 600                 605             


Phe Gly Ala Pro Ser Gln Trp Met His His Arg Thr Pro Ser Met His 
    610                 615                 620                 


Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Gln Ala 
625                 630                 635                 640 


Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr 
                645                 650                 655     


Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala Glu Glu 
            660                 665                 670         


Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln Ala Trp 
        675                 680                 685             


Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu 
    690                 695                 700                 


Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe 
705                 710                 715                 720 


Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu 
                725                 730                 735     


Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro Leu Pro 
            740                 745                 750         


Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu 
        755                 760                 765             


Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr 
    770                 775                 780                 


Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr 
785                 790                 795                 800 


Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe 
                805                 810                 815     


Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly 
            820                 825                 830         


Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser 
        835                 840                 845             


Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val 
    850                 855                 860                 


Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu 
865                 870                 875                 880 


Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His Gln Trp 
                885                 890                 895     


Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val His Gly 
            900                 905                 910         


Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu 
        915                 920                 925             


Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln 
    930                 935                 940                 


Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Val Thr Gly Ile Ile 
945                 950                 955                 960 


Val Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala 
                965                 970                 975     


Gly Leu Arg Arg Ser Pro His Arg Glu Ser Leu Pro Gly Leu Ser Ser 
            980                 985                 990         


Thr Ala Thr Pro Gly Asn Pro Ala  Leu Tyr Ser Arg Ala  Arg Leu Gly 
        995                 1000                 1005             


Pro Pro  Ser Pro Pro Ala Ala  His Glu Leu Glu Ser  Leu Val His 
    1010                 1015                 1020             


Pro His  Pro Gln Asp Trp Ser  Pro Pro Pro Ser Asp  Val Glu Asp 
    1025                 1030                 1035             


Arg Ala  Glu Val His Ser Leu  Met Gly Gly Gly Val  Ser Glu Gly 
    1040                 1045                 1050             


Arg Ser  His Ser Lys Arg Lys  Ile Ser Trp Ala Gln  Pro Ser Gly 
    1055                 1060                 1065             


Leu Ser  Trp Ala Gly Ser Trp  Ala Gly Cys Glu Leu  Pro Gln Ala 
    1070                 1075                 1080             


Gly Pro  Arg Pro Ala Leu Thr  Arg Ala Leu Leu Pro  Pro Ala Gly 
    1085                 1090                 1095             


Thr Gly  Gln Thr Leu Leu Leu  Gln Ala Leu Val Tyr  Asp Ala Ile 
    1100                 1105                 1110             


Lys Gly  Asn Gly Arg Lys Lys  Ser Pro Pro Ala Cys  Arg Asn Gln 
    1115                 1120                 1125             


Val Glu  Ala Glu Val Ile Val  His Ser Asp Phe Ser  Ala Ser Asn 
    1130                 1135                 1140             


Gly Asn  Pro Asp Leu His Leu  Gln Asp Leu Glu Pro  Glu Asp Pro 
    1145                 1150                 1155             


Leu Pro  Pro Glu Ala Pro Asp  Leu Ile Ser Gly Val  Gly Asp Pro 
    1160                 1165                 1170             


Gly Gln  Gly Ala Ala Trp Leu  Asp Arg Glu Leu Gly  Gly Cys Glu 
    1175                 1180                 1185             


Leu Ala  Ala Pro Gly Pro Asp  Arg Leu Thr Cys Leu  Pro Glu Ala 
    1190                 1195                 1200             


Ala Ser  Ala Ser Cys Ser Tyr  Pro Asp Leu Gln Pro  Gly Glu Val 
    1205                 1210                 1215             


Leu Glu  Glu Thr Pro Gly Asp  Ser Cys Gln Leu Lys  Ser Pro Cys 
    1220                 1225                 1230             


Pro Leu  Gly Ala Ser Pro Gly  Leu Pro Arg Ser Pro  Val Ser Ser 
    1235                 1240                 1245             


Ser Ala  
    1250 


<210>  1741
<211>  2846
<212>  DNA
<213>  Homosapiens

<400>  1741
ggatcgcaac gaaccggaag tgctaaagcc tccgaggcca aggccgctgc tactgccgcc     60

gctgcttctt agtgccgcgt tcgccgcctg ggttgtcacc ggcgccgccg ccgaggaagc    120

cactgcaacc aggaccggag tggaggcggc gcagcatgaa gcggcgcagg cccgctccat    180

agcgcacgtc gggacggtcc gggcggggcc ggggggaagg aaaatgcaac atggcagcag    240

caatggaaac agaacagctg ggtgttgaga tatttgaaac tgcggactgt gaggagaata    300

ttgaatcaca ggatcggcct aaattggagc ctttttatgt tgagcggtat tcctggagtc    360

agcttaaaaa gctgcttgcc gataccagaa aatatcatgg ctacatgatg gctaaggcac    420

cacatgattt catgtttgtg aagaggaatg atccagatgg acctcattca gacagaatct    480

attaccttgc catgtctggt gagaacagag aaaatacact gttttattct gaaattccca    540

aaactatcaa tagagcagca gtcttaatgc tctcttggaa gcctcttttg gatctttttc    600

aggcaacact ggactatgga atgtattctc gagaagaaga actattaaga gaaagaaaac    660

gcattggaac agtcggaatt gcttcttacg attatcacca aggaagtgga acatttctgt    720

ttcaagccgg tagtggaatt tatcacgtaa aagatggagg gccacaagga tttacgcaac    780

aacctttaag gcccaatcta gtggaaacta gttgtcccaa catacggatg gatccaaaat    840

tatgccctgc tgatccagac tggattgctt ttatacatag caacgatatt tggatatcta    900

acatcgtaac cagagaagaa aggagactca cttatgtgca caatgagcta gccaacatgg    960

aagaagatgc cagatcagct ggagtcgcta cctttgttct ccaagaagaa tttgatagat   1020

attctggcta ttggtggtgt ccaaaagctg aaacaactcc cagtggtggt aaaattctta   1080

gaattctata tgaagaaaat gatgaatctg aggtggaaat tattcatgtt acatccccta   1140

tgttggaaac aaggagggca gattcattcc gttatcctaa aacaggtaca gcaaatccta   1200

aagtcacttt taagatgtca gaaataatga ttgatgctga aggaaggatc atagatgtca   1260

tagataagga actaattcaa ccttttgaga ttctatttga aggagttgaa tatattgcca   1320

gagctggatg gactcctgag ggaaaatatg cttggtccat cctactagat cgctcccaga   1380

ctcgcctaca gatagtgttg atctcacctg aattatttat cccagtagaa gatgatgtta   1440

tggaaaggca gagactcatt gagtcagtgc ctgattctgt gacgccacta attatctatg   1500

aagaaacaac agacatctgg ataaatatcc atgacatctt tcatgttttt ccccaaagtc   1560

acgaagagga aattgagttt atttttgcct ctgaatgcaa aacaggtttc cgtcatttat   1620

acaaaattac atctatttta aaggaaagca aatataaacg atccagtggt gggctgcctg   1680

ctccaagtga tttcaagtgt cctatcaaag aggagatagc aattaccagt ggtgaatggg   1740

aagttcttgg ccggcatgga tctaatatcc aagttgatga agtcagaagg ctggtatatt   1800

ttgaaggcac caaagactcc cctttagagc atcacctgta cgtagtcagt tacgtaaatc   1860

ctggagaggt gacaaggctg actgaccgtg gctactcaca ttcttgctgc atcagtcagc   1920

actgtgactt ctttataagt aagtatagta accagaagaa tccacactgt gtgtcccttt   1980

acaagctatc aagtcctgaa gatgacccaa cttgcaaaac aaaggaattt tgggccacca   2040

ttttggattc agcaggtcct cttcctgact atactcctcc agaaattttc tcttttgaaa   2100

gtactactgg atttacattg tatgggatgc tctacaagcc tcatgatcta cagcctggaa   2160

agaaatatcc tactgtgctg ttcatatatg gtggtcctca ggttgctatt gctggggccc   2220

cagtcactct gtggatcttc tatgatacag gatacacgga acgttatatg ggtcaccctg   2280

accagaatga acagggctat tacttaggat ctgtggccat gcaagcagaa aagttcccct   2340

ctgaaccaaa tcgtttactg ctcttacatg gtttcctgga tgagaatgtc cattttgcac   2400

ataccagtat attactgagt tttttagtga gggctggaaa gccatatgat ttacagatct   2460

atcctcagga gagacacagc ataagagttc ctgaatcggg agaacattat gaactgcatc   2520

ttttgcacta ccttcaagaa aaccttggat cacgtattgc tgctctaaaa gtgatataat   2580

tttgacctgt gtagaactct ctggtataca ctggctattt aaccaaatga ggaggtttaa   2640

tcaacagaaa acacagaatt gatcatcaca ttttgatacc tgccatgtaa catctactcc   2700

tgaaaataaa tgtggtgcca tgcaggggtc tacggtttgt ggtagtaatc taatacctta   2760

accccacatg ctcaaaatca aatgatacat attcctgaga gacccagcaa taccataaga   2820

attactaaaa aaaaaaaaaa aaaaaa                                        2846


<210>  1742
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  1742

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp Ile Phe Tyr Asp 
            660                 665                 670         


Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp Gln Asn Glu Gln 
        675                 680                 685             


Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu Lys Phe Pro Ser 
    690                 695                 700                 


Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu Asp Glu Asn Val 
705                 710                 715                 720 


His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu Val Arg Ala Gly 
                725                 730                 735     


Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg His Ser Ile Arg 
            740                 745                 750         


Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu Leu His Tyr Leu 
        755                 760                 765             


Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys Val Ile 
    770                 775                 780         


<210>  1743
<211>  3129
<212>  DNA
<213>  Homosapiens

<400>  1743
ggatcgcaac gaaccggaag tgctaaagcc tccgaggcca aggccgctgc tactgccgcc     60

gctgcttctt agtgccgcgt tcgccgcctg ggttgtcacc ggcgccgccg ccgaggaagc    120

cactgcaacc aggaccggag tggaggcggc gcagcatgaa gcggcgcagg cccgctccat    180

agcgcacgtc gggacggtcc gggcggggcc ggggggaagg ctttgatggt gaggaaagga    240

aagattcctg tgagaagagc aggatgagca gagggattct atgcttgaag tcgagtcact    300

tgaaaaagat ctctttgaat gtggaagaga tctgagcaga tgaaaataaa atcaggaaaa    360

tgcaacatgg cagcagcaat ggaaacagaa cagctgggtg ttgagatatt tgaaactgcg    420

gactgtgagg agaatattga atcacaggat cggcctaaat tggagccttt ttatgttgag    480

cggtattcct ggagtcagct taaaaagctg cttgccgata ccagaaaata tcatggctac    540

atgatggcta aggcaccaca tgatttcatg tttgtgaaga ggaatgatcc agatggacct    600

cattcagaca gaatctatta ccttgccatg tctggtgaga acagagaaaa tacactgttt    660

tattctgaaa ttcccaaaac tatcaataga gcagcagtct taatgctctc ttggaagcct    720

cttttggatc tttttcaggc aacactggac tatggaatgt attctcgaga agaagaacta    780

ttaagagaaa gaaaacgcat tggaacagtc ggaattgctt cttacgatta tcaccaagga    840

agtggaacat ttctgtttca agccggtagt ggaatttatc acgtaaaaga tggagggcca    900

caaggattta cgcaacaacc tttaaggccc aatctagtgg aaactagttg tcccaacata    960

cggatggatc caaaattatg ccctgctgat ccagactgga ttgcttttat acatagcaac   1020

gatatttgga tatctaacat cgtaaccaga gaagaaagga gactcactta tgtgcacaat   1080

gagctagcca acatggaaga agatgccaga tcagctggag tcgctacctt tgttctccaa   1140

gaagaatttg atagatattc tggctattgg tggtgtccaa aagctgaaac aactcccagt   1200

ggtggtaaaa ttcttagaat tctatatgaa gaaaatgatg aatctgaggt ggaaattatt   1260

catgttacat cccctatgtt ggaaacaagg agggcagatt cattccgtta tcctaaaaca   1320

ggtacagcaa atcctaaagt cacttttaag atgtcagaaa taatgattga tgctgaagga   1380

aggatcatag atgtcataga taaggaacta attcaacctt ttgagattct atttgaagga   1440

gttgaatata ttgccagagc tggatggact cctgagggaa aatatgcttg gtccatccta   1500

ctagatcgct cccagactcg cctacagata gtgttgatct cacctgaatt atttatccca   1560

gtagaagatg atgttatgga aaggcagaga ctcattgagt cagtgcctga ttctgtgacg   1620

ccactaatta tctatgaaga aacaacagac atctggataa atatccatga catctttcat   1680

gtttttcccc aaagtcacga agaggaaatt gagtttattt ttgcctctga atgcaaaaca   1740

ggtttccgtc atttatacaa aattacatct attttaaagg aaagcaaata taaacgatcc   1800

agtggtgggc tgcctgctcc aagtgatttc aagtgtccta tcaaagagga gatagcaatt   1860

accagtggtg aatgggaagt tcttggccgg catggatcta atatccaagt tgatgaagtc   1920

agaaggctgg tatattttga aggcaccaaa gactcccctt tagagcatca cctgtacgta   1980

gtcagttacg taaatcctgg agaggtgaca aggctgactg accgtggcta ctcacattct   2040

tgctgcatca gtcagcactg tgacttcttt ataagtaagt atagtaacca gaagaatcca   2100

cactgtgtgt ccctttacaa gctatcaagt cctgaagatg acccaacttg caaaacaaag   2160

gaattttggg ccaccatttt ggattcagca ggtcctcttc ctgactatac tcctccagaa   2220

attttctctt ttgaaagtac tactggattt acattgtatg ggatgctcta caagcctcat   2280

gatctacagc ctggaaagaa atatcctact gtgctgttca tatatggtgg tcctcaggtg   2340

cagttggtga ataatcggtt taaaggagtc aagtatttcc gcttgaatac cctagcctct   2400

ctaggttatg tggttgtagt gatagacaac aggggatcct gtcaccgagg gcttaaattt   2460

gaaggcgcct ttaaatataa aatggttgct attgctgggg ccccagtcac tctgtggatc   2520

ttctatgata caggatacac ggaacgttat atgggtcacc ctgaccagaa tgaacagggc   2580

tattacttag gatctgtggc catgcaagca gaaaagttcc cctctgaacc aaatcgttta   2640

ctgctcttac atggtttcct ggatgagaat gtccattttg cacataccag tatattactg   2700

agttttttag tgagggctgg aaagccatat gatttacaga tctatcctca ggagagacac   2760

agcataagag ttcctgaatc gggagaacat tatgaactgc atcttttgca ctaccttcaa   2820

gaaaaccttg gatcacgtat tgctgctcta aaagtgatat aattttgacc tgtgtagaac   2880

tctctggtat acactggcta tttaaccaaa tgaggaggtt taatcaacag aaaacacaga   2940

attgatcatc acattttgat acctgccatg taacatctac tcctgaaaat aaatgtggtg   3000

ccatgcaggg gtctacggtt tgtggtagta atctaatacc ttaaccccac atgctcaaaa   3060

tcaaatgata catattcctg agagacccag caataccata agaattacta aaaaaaaaaa   3120

aaaaaaaaa                                                           3129


<210>  1744
<211>  847
<212>  PRT
<213>  Homosapiens

<400>  1744

Met Trp Lys Arg Ser Glu Gln Met Lys Ile Lys Ser Gly Lys Cys Asn 
1               5                   10                  15      


Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
            20                  25                  30          


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
        35                  40                  45              


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
    50                  55                  60                  


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
65                  70                  75                  80  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
                85                  90                  95      


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
            100                 105                 110         


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
        115                 120                 125             


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
    130                 135                 140                 


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
                165                 170                 175     


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
            180                 185                 190         


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
        195                 200                 205             


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
    210                 215                 220                 


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
225                 230                 235                 240 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
                245                 250                 255     


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
            260                 265                 270         


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
        275                 280                 285             


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
    290                 295                 300                 


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
305                 310                 315                 320 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
                325                 330                 335     


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
            340                 345                 350         


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
        355                 360                 365             


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
    370                 375                 380                 


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
385                 390                 395                 400 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
                405                 410                 415     


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
            420                 425                 430         


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
        435                 440                 445             


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
    450                 455                 460                 


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
465                 470                 475                 480 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
                485                 490                 495     


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
            500                 505                 510         


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
        515                 520                 525             


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
    530                 535                 540                 


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
545                 550                 555                 560 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
                565                 570                 575     


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
            580                 585                 590         


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
        595                 600                 605             


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
    610                 615                 620                 


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
625                 630                 635                 640 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
                645                 650                 655     


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
            660                 665                 670         


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
        675                 680                 685             


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
    690                 695                 700                 


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
705                 710                 715                 720 


Lys Met Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp Ile Phe Tyr 
                725                 730                 735     


Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp Gln Asn Glu 
            740                 745                 750         


Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu Lys Phe Pro 
        755                 760                 765             


Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu Asp Glu Asn 
    770                 775                 780                 


Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu Val Arg Ala 
785                 790                 795                 800 


Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg His Ser Ile 
                805                 810                 815     


Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu Leu His Tyr 
            820                 825                 830         


Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys Val Ile 
        835                 840                 845         


<210>  1745
<211>  3146
<212>  DNA
<213>  Homosapiens

<400>  1745
ggatcgcaac gaaccggaag tgctaaagcc tccgaggcca aggccgctgc tactgccgcc     60

gctgcttctt agtgccgcgt tcgccgcctg ggttgtcacc ggcgccgccg ccgaggaagc    120

cactgcaacc aggaccggag tggaggcggc gcagcatgaa gcggcgcagg cccgctccat    180

agcgcacgtc gggacggtcc gggcggggcc ggggggaagg aaaatgcaac atggcagcag    240

caatggaaac agaacagctg ggtgttgaga tatttgaaac tgcggactgt gaggagaata    300

ttgaatcaca ggatcggcct aaattggagc ctttttatgt tgagcggtat tcctggagtc    360

agcttaaaaa gctgcttgcc gataccagaa aatatcatgg ctacatgatg gctaaggcac    420

cacatgattt catgtttgtg aagaggaatg atccagatgg acctcattca gacagaatct    480

attaccttgc catgtctggt gagaacagag aaaatacact gttttattct gaaattccca    540

aaactatcaa tagagcagca gtcttaatgc tctcttggaa gcctcttttg gatctttttc    600

aggcaacact ggactatgga atgtattctc gagaagaaga actattaaga gaaagaaaac    660

gcattggaac agtcggaatt gcttcttacg attatcacca aggaagtgga acatttctgt    720

ttcaagccgg tagtggaatt tatcacgtaa aagatggagg gccacaagga tttacgcaac    780

aacctttaag gcccaatcta gtggaaacta gttgtcccaa catacggatg gatccaaaat    840

tatgccctgc tgatccagac tggattgctt ttatacatag caacgatatt tggatatcta    900

acatcgtaac cagagaagaa aggagactca cttatgtgca caatgagcta gccaacatgg    960

aagaagatgc cagatcagct ggagtcgcta cctttgttct ccaagaagaa tttgatagat   1020

attctggcta ttggtggtgt ccaaaagctg aaacaactcc cagtggtggt aaaattctta   1080

gaattctata tgaagaaaat gatgaatctg aggtggaaat tattcatgtt acatccccta   1140

tgttggaaac aaggagggca gattcattcc gttatcctaa aacaggtaca gcaaatccta   1200

aagtcacttt taagatgtca gaaataatga ttgatgctga aggaaggatc atagatgtca   1260

tagataagga actaattcaa ccttttgaga ttctatttga aggagttgaa tatattgcca   1320

gagctggatg gactcctgag ggaaaatatg cttggtccat cctactagat cgctcccaga   1380

ctcgcctaca gatagtgttg atctcacctg aattatttat cccagtagaa gatgatgtta   1440

tggaaaggca gagactcatt gagtcagtgc ctgattctgt gacgccacta attatctatg   1500

aagaaacaac agacatctgg ataaatatcc atgacatctt tcatgttttt ccccaaagtc   1560

acgaagagga aattgagttt atttttgcct ctgaatgcaa aacaggtttc cgtcatttat   1620

acaaaattac atctatttta aaggaaagca aatataaacg atccagtggt gggctgcctg   1680

ctccaagtga tttcaagtgt cctatcaaag aggagatagc aattaccagt ggtgaatggg   1740

aagttcttgg ccggcatgga tctaatatcc aagttgatga agtcagaagg ctggtatatt   1800

ttgaaggcac caaagactcc cctttagagc atcacctgta cgtagtcagt tacgtaaatc   1860

ctggagaggt gacaaggctg actgaccgtg gctactcaca ttcttgctgc atcagtcagc   1920

actgtgactt ctttataagt aagtatagta accagaagaa tccacactgt gtgtcccttt   1980

acaagctatc aagtcctgaa gatgacccaa cttgcaaaac aaaggaattt tgggccacca   2040

ttttggattc agcaggtcct cttcctgact atactcctcc agaaattttc tcttttgaaa   2100

gtactactgg atttacattg tatgggatgc tctacaagcc tcatgatcta cagcctggaa   2160

agaaatatcc tactgtgctg ttcatatatg gtggtcctca ggtgcagttg gtgaataatc   2220

ggtttaaagg agtcaagtat ttccgcttga ataccctagc ctctctaggt tatgtggttg   2280

tagtgataga caacagggga tcctgtcacc gagggcttaa atttgaaggc gcctttaaat   2340

ataaaatggg tcaaatagaa attgacgatc aggtggaagg actccaatat ctagcttctc   2400

gatatgattt cattgactta gatcgtgtgg gcatccacgg ctggtcctat ggaggatacc   2460

tctccctgat ggcattaatg cagaggtcag atatcttcag ggttgctatt gctggggccc   2520

cagtcactct gtggatcttc tatgatacag gatacacgga acgttatatg ggtcaccctg   2580

accagaatga acagggctat tacttaggat ctgtggccat gcaagcagaa aagttcccct   2640

ctgaaccaaa tcgtttactg ctcttacatg gtttcctgga tgagaatgtc cattttgcac   2700

ataccagtat attactgagt tttttagtga gggctggaaa gccatatgat ttacagatct   2760

atcctcagga gagacacagc ataagagttc ctgaatcggg agaacattat gaactgcatc   2820

ttttgcacta ccttcaagaa aaccttggat cacgtattgc tgctctaaaa gtgatataat   2880

tttgacctgt gtagaactct ctggtataca ctggctattt aaccaaatga ggaggtttaa   2940

tcaacagaaa acacagaatt gatcatcaca ttttgatacc tgccatgtaa catctactcc   3000

tgaaaataaa tgtggtgcca tgcaggggtc tacggtttgt ggtagtaatc taatacctta   3060

accccacatg ctcaaaatca aatgatacat attcctgaga gacccagcaa taccataaga   3120

attactaaaa aaaaaaaaaa aaaaaa                                        3146


<210>  1746
<211>  882
<212>  PRT
<213>  Homosapiens

<400>  1746

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
            660                 665                 670         


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
        675                 680                 685             


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
    690                 695                 700                 


Lys Met Gly Gln Ile Glu Ile Asp Asp Gln Val Glu Gly Leu Gln Tyr 
705                 710                 715                 720 


Leu Ala Ser Arg Tyr Asp Phe Ile Asp Leu Asp Arg Val Gly Ile His 
                725                 730                 735     


Gly Trp Ser Tyr Gly Gly Tyr Leu Ser Leu Met Ala Leu Met Gln Arg 
            740                 745                 750         


Ser Asp Ile Phe Arg Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp 
        755                 760                 765             


Ile Phe Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp 
    770                 775                 780                 


Gln Asn Glu Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu 
785                 790                 795                 800 


Lys Phe Pro Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu 
                805                 810                 815     


Asp Glu Asn Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu 
            820                 825                 830         


Val Arg Ala Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg 
        835                 840                 845             


His Ser Ile Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu 
    850                 855                 860                 


Leu His Tyr Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys 
865                 870                 875                 880 


Val Ile 
        


<210>  1747
<211>  3055
<212>  DNA
<213>  Homosapiens

<400>  1747
gaggaagccg aggctctgag attccgagtc aaccaccgtt cactgggcgc cccttgagct     60

ctgggcgctg gcctcctggc ttccacgctt tgatggtgag gaaaggaaag attcctgtga    120

gaagagcagg atgagcagag ggattctatg cttgaagtcg agtcacttga aaaagatctc    180

tttgaatgtg gaagagatct gagcagatga aaataaaatc aggaaaatgc aacatggcag    240

cagcaatgga aacagaacag ctgggtgttg agatatttga aactgcggac tgtgaggaga    300

atattgaatc acaggatcgg cctaaattgg agccttttta tgttgagcgg tattcctgga    360

gtcagcttaa aaagctgctt gccgatacca gaaaatatca tggctacatg atggctaagg    420

caccacatga tttcatgttt gtgaagagga atgatccaga tggacctcat tcagacagaa    480

tctattacct tgccatgtct ggtgagaaca gagaaaatac actgttttat tctgaaattc    540

ccaaaactat caatagagca gcagtcttaa tgctctcttg gaagcctctt ttggatcttt    600

ttcaggcaac actggactat ggaatgtatt ctcgagaaga agaactatta agagaaagaa    660

aacgcattgg aacagtcgga attgcttctt acgattatca ccaaggaagt ggaacatttc    720

tgtttcaagc cggtagtgga atttatcacg taaaagatgg agggccacaa ggatttacgc    780

aacaaccttt aaggcccaat ctagtggaaa ctagttgtcc caacatacgg atggatccaa    840

aattatgccc tgctgatcca gactggattg cttttataca tagcaacgat atttggatat    900

ctaacatcgt aaccagagaa gaaaggagac tcacttatgt gcacaatgag ctagccaaca    960

tggaagaaga tgccagatca gctggagtcg ctacctttgt tctccaagaa gaatttgata   1020

gatattctgg ctattggtgg tgtccaaaag ctgaaacaac tcccagtggt ggtaaaattc   1080

ttagaattct atatgaagaa aatgatgaat ctgaggtgga aattattcat gttacatccc   1140

ctatgttgga aacaaggagg gcagattcat tccgttatcc taaaacaggt acagcaaatc   1200

ctaaagtcac ttttaagatg tcagaaataa tgattgatgc tgaaggaagg atcatagatg   1260

tcatagataa ggaactaatt caaccttttg agattctatt tgaaggagtt gaatatattg   1320

ccagagctgg atggactcct gagggaaaat atgcttggtc catcctacta gatcgctccc   1380

agactcgcct acagatagtg ttgatctcac ctgaattatt tatcccagta gaagatgatg   1440

ttatggaaag gcagagactc attgagtcag tgcctgattc tgtgacgcca ctaattatct   1500

atgaagaaac aacagacatc tggataaata tccatgacat ctttcatgtt tttccccaaa   1560

gtcacgaaga ggaaattgag tttatttttg cctctgaatg caaaacaggt ttccgtcatt   1620

tatacaaaat tacatctatt ttaaaggaaa gcaaatataa acgatccagt ggtgggctgc   1680

ctgctccaag tgatttcaag tgtcctatca aagaggagat agcaattacc agtggtgaat   1740

gggaagttct tggccggcat ggatctaata tccaagttga tgaagtcaga aggctggtat   1800

attttgaagg caccaaagac tcccctttag agcatcacct gtacgtagtc agttacgtaa   1860

atcctggaga ggtgacaagg ctgactgacc gtggctactc acattcttgc tgcatcagtc   1920

agcactgtga cttctttata agtaagtata gtaaccagaa gaatccacac tgtgtgtccc   1980

tttacaagct atcaagtcct gaagatgacc caacttgcaa aacaaaggaa ttttgggcca   2040

ccattttgga ttcagcaggt cctcttcctg actatactcc tccagaaatt ttctcttttg   2100

aaagtactac tggatttaca ttgtatggga tgctctacaa gcctcatgat ctacagcctg   2160

gaaagaaata tcctactgtg ctgttcatat atggtggtcc tcaggtgcag ttggtgaata   2220

atcggtttaa aggagtcaag tatttccgct tgaataccct agcctctcta ggttatgtgg   2280

ttgtagtgat agacaacagg ggatcctgtc accgagggct taaatttgaa ggcgccttta   2340

aatataaaat gggtcaaata gaaattgacg atcaggtgga aggactccaa tatctagctt   2400

ctcgatatga tttcattgac ttagatcgtg tgggcatcca cggctggtcc tatggaggat   2460

acctctccct gatggcatta atgcagaggt cagatatctt cagggttgct attgctgggg   2520

ccccagtcac tctgtggatc ttctatgata caggatacac ggaacgttat atgggtcacc   2580

ctgaccagaa tgaacagggc tattacttag gatctgtggc catgcaagca gaaaagttcc   2640

cctctgaacc aaatcgttta ctgctcttac atggtttcct ggatgagaat gtccattttg   2700

cacataccag tatattactg agttttttag tgagggctgg aaagccatat gatttacaga   2760

tctatcctca ggagagacac agcataagag ttcctgaatc gggagaacat tatgaactgc   2820

atcttttgca ctaccttcaa gaaaaccttg gatcacgtat tgctgctcta aaagtgatat   2880

aattttgacc tgtgtagaac tctctggtat acactggcta tttaaccaaa tgaggaggtt   2940

taatcaacag aaaacacaga attgatcatc acattttgat acctgccatg taacatctac   3000

tcctgaaaat aaatgtggtg ccatgcaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        3055


<210>  1748
<211>  898
<212>  PRT
<213>  Homosapiens

<400>  1748

Met Trp Lys Arg Ser Glu Gln Met Lys Ile Lys Ser Gly Lys Cys Asn 
1               5                   10                  15      


Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
            20                  25                  30          


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
        35                  40                  45              


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
    50                  55                  60                  


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
65                  70                  75                  80  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
                85                  90                  95      


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
            100                 105                 110         


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
        115                 120                 125             


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
    130                 135                 140                 


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
                165                 170                 175     


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
            180                 185                 190         


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
        195                 200                 205             


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
    210                 215                 220                 


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
225                 230                 235                 240 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
                245                 250                 255     


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
            260                 265                 270         


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
        275                 280                 285             


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
    290                 295                 300                 


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
305                 310                 315                 320 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
                325                 330                 335     


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
            340                 345                 350         


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
        355                 360                 365             


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
    370                 375                 380                 


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
385                 390                 395                 400 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
                405                 410                 415     


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
            420                 425                 430         


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
        435                 440                 445             


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
    450                 455                 460                 


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
465                 470                 475                 480 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
                485                 490                 495     


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
            500                 505                 510         


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
        515                 520                 525             


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
    530                 535                 540                 


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
545                 550                 555                 560 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
                565                 570                 575     


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
            580                 585                 590         


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
        595                 600                 605             


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
    610                 615                 620                 


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
625                 630                 635                 640 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
                645                 650                 655     


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
            660                 665                 670         


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
        675                 680                 685             


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
    690                 695                 700                 


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
705                 710                 715                 720 


Lys Met Gly Gln Ile Glu Ile Asp Asp Gln Val Glu Gly Leu Gln Tyr 
                725                 730                 735     


Leu Ala Ser Arg Tyr Asp Phe Ile Asp Leu Asp Arg Val Gly Ile His 
            740                 745                 750         


Gly Trp Ser Tyr Gly Gly Tyr Leu Ser Leu Met Ala Leu Met Gln Arg 
        755                 760                 765             


Ser Asp Ile Phe Arg Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp 
    770                 775                 780                 


Ile Phe Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp 
785                 790                 795                 800 


Gln Asn Glu Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu 
                805                 810                 815     


Lys Phe Pro Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu 
            820                 825                 830         


Asp Glu Asn Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu 
        835                 840                 845             


Val Arg Ala Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg 
    850                 855                 860                 


His Ser Ile Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu 
865                 870                 875                 880 


Leu His Tyr Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys 
                885                 890                 895     


Val Ile 
        


<210>  1749
<211>  1689
<212>  DNA
<213>  Homosapiens

<400>  1749
cgggagcgtg gggtatctcg aggtgccggg ttgcaggcgc tcaggggcgc tagggtttga     60

ggcctgcttt ctgctcgcgc cagcagagca ctacctgagg cagcgaggcg cagcgagcct    120

agcctccccg cgccctgggc agtgtggcca tggagaatca ggtgttgacg ccgcatgtct    180

actgggctca gcgacaccgc gagctatatc tgcgcgtgga gctgagtgac gtacagaacc    240

ctgccatcag catcactgaa aacgtgctgc atttcaaagc tcaaggacat ggtgccaaag    300

gagacaatgt ctatgaattt cacctggagt tcttagacct tgtgaaacca gagcctgttt    360

acaaactgac ccagaggcag gtaaacatta cagtacagaa gaaagtgagt cagtggtggg    420

agagactcac aaagcaggaa aagcgaccac tgtttttggc tcctgacttt gatcgttggc    480

tggatgaatc tgatgcggaa atggagctca gagctaagga agaagagcgc ctaaataaac    540

tccgactgga aagcgaaggc tctcctgaaa ctcttacaaa cttaaggaaa ggatacctgt    600

ttatgtataa tcttgtgcaa ttcttgggat tctcctggat ctttgtcaac ctgactgtgc    660

gattctgtat cttgggaaaa gagtcctttt atgacacatt ccatactgtg gctgacatga    720

tgtatttctg ccagatgctg gcagttgtgg aaactatcaa tgcagcaatt ggagtcacta    780

cgtcaccggt gctgccttct ctgatccagc ttcttggaag aaattttatt ttgtttatca    840

tctttggcac catggaagaa atgcagaaca aagctgtggt tttctttgtg ttttatttgt    900

ggagtgcaat tgaaattttc aggtactctt tctacatgct gacgtgcatt gacatggatt    960

ggaaggtgct cacatggctt cgttacactc tgtggattcc cttatatcca ctgggatgtt   1020

tggtggaagc tgtctcagtg attcagtcca ttccaatatt caatgagacc ggacgattca   1080

gtttcacatt gccatatcca gtgaaaatca aagttagatt ttcctttttt cttcagattt   1140

atcttataat gatattttta ggtttataca taaattttcg tcacctttat aaacagcgca   1200

gacggcgcta tggaaaaaaa agaaaaagat ccactaaaaa gaaagattta gatggcttct   1260

tgccagtttg agcctaatct gattcttaca gttttacctt cttgaaccaa tgtaaaagtt   1320

tttttaatgt taaatgatta aattctcagt gaggctatct tccttttccc cagtaacatt   1380

cctgaattta ctgttatctt attgtagtac ttgcatgaca tggattcctg atatctgatg   1440

agaggttcat tcttgtgtat tcagttaatg acaccaaaag gctcagccca ccccaaccct   1500

atctcatgtt cagtctgtct aatacatgcc agagattttt ttttcaaaaa gtgctttatc   1560

cctacaatgt actgacagtt cttacagttg aggatttggt tcttttcagc taattgcttg   1620

gtggattaaa aaaagcaaga ctaatgtcaa ctctaatgga aggctggtta aaagtggact   1680

caggcaagg                                                           1689


<210>  1750
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  1750

Met Glu Asn Gln Val Leu Thr Pro His Val Tyr Trp Ala Gln Arg His 
1               5                   10                  15      


Arg Glu Leu Tyr Leu Arg Val Glu Leu Ser Asp Val Gln Asn Pro Ala 
            20                  25                  30          


Ile Ser Ile Thr Glu Asn Val Leu His Phe Lys Ala Gln Gly His Gly 
        35                  40                  45              


Ala Lys Gly Asp Asn Val Tyr Glu Phe His Leu Glu Phe Leu Asp Leu 
    50                  55                  60                  


Val Lys Pro Glu Pro Val Tyr Lys Leu Thr Gln Arg Gln Val Asn Ile 
65                  70                  75                  80  


Thr Val Gln Lys Lys Val Ser Gln Trp Trp Glu Arg Leu Thr Lys Gln 
                85                  90                  95      


Glu Lys Arg Pro Leu Phe Leu Ala Pro Asp Phe Asp Arg Trp Leu Asp 
            100                 105                 110         


Glu Ser Asp Ala Glu Met Glu Leu Arg Ala Lys Glu Glu Glu Arg Leu 
        115                 120                 125             


Asn Lys Leu Arg Leu Glu Ser Glu Gly Ser Pro Glu Thr Leu Thr Asn 
    130                 135                 140                 


Leu Arg Lys Gly Tyr Leu Phe Met Tyr Asn Leu Val Gln Phe Leu Gly 
145                 150                 155                 160 


Phe Ser Trp Ile Phe Val Asn Leu Thr Val Arg Phe Cys Ile Leu Gly 
                165                 170                 175     


Lys Glu Ser Phe Tyr Asp Thr Phe His Thr Val Ala Asp Met Met Tyr 
            180                 185                 190         


Phe Cys Gln Met Leu Ala Val Val Glu Thr Ile Asn Ala Ala Ile Gly 
        195                 200                 205             


Val Thr Thr Ser Pro Val Leu Pro Ser Leu Ile Gln Leu Leu Gly Arg 
    210                 215                 220                 


Asn Phe Ile Leu Phe Ile Ile Phe Gly Thr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Lys Ala Val Val Phe Phe Val Phe Tyr Leu Trp Ser Ala Ile Glu Ile 
                245                 250                 255     


Phe Arg Tyr Ser Phe Tyr Met Leu Thr Cys Ile Asp Met Asp Trp Lys 
            260                 265                 270         


Val Leu Thr Trp Leu Arg Tyr Thr Leu Trp Ile Pro Leu Tyr Pro Leu 
        275                 280                 285             


Gly Cys Leu Val Glu Ala Val Ser Val Ile Gln Ser Ile Pro Ile Phe 
    290                 295                 300                 


Asn Glu Thr Gly Arg Phe Ser Phe Thr Leu Pro Tyr Pro Val Lys Ile 
305                 310                 315                 320 


Lys Val Arg Phe Ser Phe Phe Leu Gln Ile Tyr Leu Ile Met Ile Phe 
                325                 330                 335     


Leu Gly Leu Tyr Ile Asn Phe Arg His Leu Tyr Lys Gln Arg Arg Arg 
            340                 345                 350         


Arg Tyr Gly Lys Lys Arg Lys Arg Ser Thr Lys Lys Lys Asp Leu Asp 
        355                 360                 365             


Gly Phe Leu Pro Val 
    370             


<210>  1751
<211>  2538
<212>  DNA
<213>  Homosapiens

<400>  1751
tgcctttcgc tgcttgttgg ggttacaggt gaaggggtta tgggtgaaga acaacccagg     60

gccagcgctt ggccttcccg ccaccgtggc ggccgccccg cgctgtctgt gaggcgccag    120

ttccggggcg ctgctcccgg cctcccctcg ctctgaggct cggggtcccc agctccgcgt    180

aaactgcacg atttcgccct ctgctcagct cccctctgcc ccctctttcc aagagagact    240

tccagatccc acattttctt gactgatttt taagcatttc ttcgtttata gctgtctgtt    300

tgcattctga ttgggaacac tgggatcatt ttcatcatgc cgacagtggt ggtaatggat    360

gtatcccttt ccatgacccg acctgtgtct attgaggggt ccgaggaata ccagcgtaag    420

cacctagcag cccatggttt aacgatgctg tttgagcaca tggccacaaa ttacaagctt    480

gaatttacag cacttgtggt tttttcatca ctttgggagt tgatggtccc cttcacgaga    540

gattataata ccctacagga agcactaagt aatatggatg attatgacaa aacctgcttg    600

gggtctgcat tagttggtgt ttgcaatatc gttcagcaag aatggggtgg tgcaattcct    660

tgccaggttg tcctggtgac agacggctgt cttggcattg gtagagggtc actgcgacat    720

tccctagcca ctcaaaatca acgaagtgag agcaacaggt ttccactacc ttttcctttc    780

ccatctaagt tatatatcat gtgcatggcg aatttggagg agctccagag caccgattcc    840

ttggaatgcc ttgaacgtct catagattta aacaatggtg aagggcagat ttttactatt    900

gatggccccc tgtgcttgaa gaatgtacag tctatgtttg gaaaactgat aggtttggca    960

tatacgcctt tccatgctgt tctcaagtgt ggccacctaa ctgctgatgt acaagtcttc   1020

cccaggccag aaccttttgt tgtagatgaa gaaattgatc ctatccctaa agtcattaac   1080

acagatttgg aaatagtggg atttattgat atagctgata tctcaagtcc cccagttctg   1140

tccagacatc tggtcttacc tatagcactt aacaaagaag gtgatgaggt gggtactggc   1200

atcactgatg acaatgaaga tgaaaattca gccaatcaga ttgcaggcaa aatacccaac   1260

ttttgtgtcc tgctccatgg tagcctaaaa gtggaaggaa tggtagcgat tgttcaatta   1320

ggtcctgaat ggcatggaat gctctactcc caagctgaca gcaagaagaa atcaaacctc   1380

atgatgtctc tctttgagcc tggcccagaa cctctcccat ggctagggaa aatggcacag   1440

ttgggtccta tttcagatgc taaagaaaac ccttatggcg aggatgacaa taagagtcca   1500

ttccccctgc agcccaaaaa caagcgcagt tatgcccaga atgtgactgt ctggatcaaa   1560

cccagcggcc tgcagacaga tgtacagaag attttaagaa atgcaaggaa actacctgaa   1620

aaaacacaga cattctataa ggagctgaac cgtttgcgaa aggccgctct agcctttggt   1680

ttcctggacc tgctgaaagg ggtggctgac atgctggaaa gggaatgcac actgctgcct   1740

gagacagccc accctgatgc tgcattccag ctgacccatg ctgcccagca gctcaagctg   1800

gccagtaccg gcacctctga gtatgccgct tatgaccaga acatcacacc tttgcacacg   1860

gacttctctg ggagcagcac tgaaagaatt tgaaactgac ttttggagct ttccttcttt   1920

tttcatttca actgaaaatg ctttaggtaa aaacctttcc agtatgttca cctctagaat   1980

agccacccaa agaccttcct gaggctgcct cagaagcacc acttgctgtt ttgaatgact   2040

ctactagtat gagaaggatg tgaaggtggt tggctggttg ggctttaact tcctgggatt   2100

cataattttt aagcttggaa gatagctgct gttcccatga tgggcacatt tcctgagaag   2160

cttgaatgac tgatgagcat agagcacccc tgccttcctc aggaaacctg accggcaggg   2220

gctctctggc ttcctgaaag cttcacctct tccctcgttt atatctcaac tgtaagggca   2280

ttttcaagct tctgttcatg gaatgagcaa ctcagactgt ctggagcttg ctgagtacaa   2340

acacaccacc actaagtttc agaactttcc ttaggacttg ggcaaaatgt ggtggtaact   2400

cttaagtgct tttggtatct cttgagattc taacttttaa agagcaacca ttaatgtgta   2460

aaatgattcc tattattcaa ggtttttttt taatgaaaat aaaatatttg attttctaga   2520

aaaaaaaaaa aaaaaaaa                                                 2538


<210>  1752
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  1752

Met Pro Thr Val Val Val Met Asp Val Ser Leu Ser Met Thr Arg Pro 
1               5                   10                  15      


Val Ser Ile Glu Gly Ser Glu Glu Tyr Gln Arg Lys His Leu Ala Ala 
            20                  25                  30          


His Gly Leu Thr Met Leu Phe Glu His Met Ala Thr Asn Tyr Lys Leu 
        35                  40                  45              


Glu Phe Thr Ala Leu Val Val Phe Ser Ser Leu Trp Glu Leu Met Val 
    50                  55                  60                  


Pro Phe Thr Arg Asp Tyr Asn Thr Leu Gln Glu Ala Leu Ser Asn Met 
65                  70                  75                  80  


Asp Asp Tyr Asp Lys Thr Cys Leu Gly Ser Ala Leu Val Gly Val Cys 
                85                  90                  95      


Asn Ile Val Gln Gln Glu Trp Gly Gly Ala Ile Pro Cys Gln Val Val 
            100                 105                 110         


Leu Val Thr Asp Gly Cys Leu Gly Ile Gly Arg Gly Ser Leu Arg His 
        115                 120                 125             


Ser Leu Ala Thr Gln Asn Gln Arg Ser Glu Ser Asn Arg Phe Pro Leu 
    130                 135                 140                 


Pro Phe Pro Phe Pro Ser Lys Leu Tyr Ile Met Cys Met Ala Asn Leu 
145                 150                 155                 160 


Glu Glu Leu Gln Ser Thr Asp Ser Leu Glu Cys Leu Glu Arg Leu Ile 
                165                 170                 175     


Asp Leu Asn Asn Gly Glu Gly Gln Ile Phe Thr Ile Asp Gly Pro Leu 
            180                 185                 190         


Cys Leu Lys Asn Val Gln Ser Met Phe Gly Lys Leu Ile Gly Leu Ala 
        195                 200                 205             


Tyr Thr Pro Phe His Ala Val Leu Lys Cys Gly His Leu Thr Ala Asp 
    210                 215                 220                 


Val Gln Val Phe Pro Arg Pro Glu Pro Phe Val Val Asp Glu Glu Ile 
225                 230                 235                 240 


Asp Pro Ile Pro Lys Val Ile Asn Thr Asp Leu Glu Ile Val Gly Phe 
                245                 250                 255     


Ile Asp Ile Ala Asp Ile Ser Ser Pro Pro Val Leu Ser Arg His Leu 
            260                 265                 270         


Val Leu Pro Ile Ala Leu Asn Lys Glu Gly Asp Glu Val Gly Thr Gly 
        275                 280                 285             


Ile Thr Asp Asp Asn Glu Asp Glu Asn Ser Ala Asn Gln Ile Ala Gly 
    290                 295                 300                 


Lys Ile Pro Asn Phe Cys Val Leu Leu His Gly Ser Leu Lys Val Glu 
305                 310                 315                 320 


Gly Met Val Ala Ile Val Gln Leu Gly Pro Glu Trp His Gly Met Leu 
                325                 330                 335     


Tyr Ser Gln Ala Asp Ser Lys Lys Lys Ser Asn Leu Met Met Ser Leu 
            340                 345                 350         


Phe Glu Pro Gly Pro Glu Pro Leu Pro Trp Leu Gly Lys Met Ala Gln 
        355                 360                 365             


Leu Gly Pro Ile Ser Asp Ala Lys Glu Asn Pro Tyr Gly Glu Asp Asp 
    370                 375                 380                 


Asn Lys Ser Pro Phe Pro Leu Gln Pro Lys Asn Lys Arg Ser Tyr Ala 
385                 390                 395                 400 


Gln Asn Val Thr Val Trp Ile Lys Pro Ser Gly Leu Gln Thr Asp Val 
                405                 410                 415     


Gln Lys Ile Leu Arg Asn Ala Arg Lys Leu Pro Glu Lys Thr Gln Thr 
            420                 425                 430         


Phe Tyr Lys Glu Leu Asn Arg Leu Arg Lys Ala Ala Leu Ala Phe Gly 
        435                 440                 445             


Phe Leu Asp Leu Leu Lys Gly Val Ala Asp Met Leu Glu Arg Glu Cys 
    450                 455                 460                 


Thr Leu Leu Pro Glu Thr Ala His Pro Asp Ala Ala Phe Gln Leu Thr 
465                 470                 475                 480 


His Ala Ala Gln Gln Leu Lys Leu Ala Ser Thr Gly Thr Ser Glu Tyr 
                485                 490                 495     


Ala Ala Tyr Asp Gln Asn Ile Thr Pro Leu His Thr Asp Phe Ser Gly 
            500                 505                 510         


Ser Ser Thr Glu Arg Ile 
        515             


<210>  1753
<211>  5374
<212>  DNA
<213>  Homosapiens

<400>  1753
cccttcacac ccgacccagc cttgaattag gattccatag gagagctggg ggcaggagaa     60

tggggtgttc cctgctgtcc agcttcagac ccactctttg agatattgga ttctgacaag    120

tttccagagc tgagaagaca gccagatgtc aaggtctgaa gggttgtgga taccccctgg    180

ctgggcttca tggagaaatc ttctctgatc accaacctga atcccagagt agcctccatc    240

ttaggacaga atgagaggcc ttctgtaacc agatataact ggccagcatg gggaaattga    300

tcaggatggg gccgcaagag aggtggttac tccggacaaa gcggcttcat tggagtcgcc    360

tcctcttctt actgggaatg ttgatcatcg gttctactta tcagcacctt aggagacccc    420

ggggcctttc ctcattgtgg gcagcagtct cttctcatca gcctataaaa ctggccagtc    480

gggacctctc cagtgaagag atgatgatga tgagcagcag cccttcaaaa cctagctccg    540

aaatgggggg taagatgctg gtaccccaag cctcagtggg cagtgatgaa gcaacactga    600

gcatgacagt ggagaatatc cccagtatgc ctaaaagaac agccaagatg atcccaacaa    660

caaccaagaa taattacagc ccaacagcag caggtacaga aagaaggaag gaagacaccc    720

caacatccag tagaacactg acttactaca cctcaacttc aagcagacaa atagtaaaaa    780

agtatacccc aacacccagg ggagaaatga agagctacag cccaactcaa gtgagggaaa    840

aggtgaagta tactccttcc ccacgtggta gaagagtagg cacttacgtg ccgtccacat    900

tcatgacaat ggaaacaagc catgcgatca cccccaggac aacagtgaaa gacagtgaca    960

ttacagcaac ctataaaata ctcgaaacca actctcttaa gagaataatg gaggaaacca   1020

ccccaaccac tctcaaggga atgtttgata gcaccccaac ttttctgaca catgaggtag   1080

aagcaaacgt cttgacttct ccaaggagcg tcatggaaaa aaacaacctg tttcccccca   1140

gaagagtgga aagtaacagc tcagcccatc cctgggggtt agtgggaaag agcaacccga   1200

agactcccca gggaacagtc ctgttgcata ccccagccac ctctgagggg caggtgacaa   1260

taagcaccat gacaggcagc agcccagcag aaaccaaagc cttcactgct gcctggagtc   1320

ttaggaatcc ttcacccagg accagtgtat cagccatcaa aacagcccca gccatagtct   1380

ggaggctggc aaagaaacct tccacagcac ccagcacctc aacaacccct acggtcaggg   1440

caaagctgac catgcaggtc catcactgtg tggttgtgaa gccaacccca gccatgctca   1500

ccactccctc cccaagcctc acaacagccc tgctcccaga ggagctcagt cctagtccct   1560

cagtgctgcc tcccagcttg ccagacctcc accccaaggg agagtacccc ccagatctgt   1620

tcagtgtgga ggagcggcgg cagggctggg tggtcctgca cgtttttggc atgatgtatg   1680

tgtttgtggc cttggccatt gtttgcgacg agtacttcgt tccagccctg ggtgtcatca   1740

cagacaagct gcagatctcc gaggatgtgg caggcgccac attcatggct gctggaggct   1800

ctgctcctga gctcttcacc tccctcatcg gtgtcttcat ttcccacagc aacgtgggca   1860

ttggtaccat tgtgggctct gctgtgttca acattctctt tgtcattggc acttgttccc   1920

tcttctcccg agagatcctc aacctcacct ggtggccctt attccgtgat gtctccttct   1980

acatccttga cctgataatg ctcatcctct tcttcctgga cagcctcatt gcctggtggg   2040

agagcctgct gctgctgctg gcctatgcct tctatgtgtt caccatgaag tggaacaagc   2100

atatcgaggt ctgggtgaag gagcagctca gcaggaggcc agtggccaag gtcatggcct   2160

tagaagacct cagcaagccg ggcgatgggg ccattgcggt ggatgagcta caggataaca   2220

agaagctgaa gctcccgtcc ttgctgaccc gagggagcag ctcgacctct ctgcacaaca   2280

gcaccatccg cagcaccatc taccagctca tgctccacag cctggacccc ctgagggaag   2340

ttcgccttgc caaggagaag gaggaggaga gcttgaatca aggggccaga gcccaacccc   2400

aggccaaagc agaaagcaaa ccagaagagg aggagccagc caagctccct gcggtcacgg   2460

tcacaccagc ccctgttcca gacatcaagg gagatcagaa ggagaatcca ggcggtcagg   2520

aagatgtggc tgaggccgag agcacaggtg aaatgccagg cgaagagggc gaaactgctg   2580

gtgaaggtga aactgaagag aaaagtggag gtgaaactca accagaaggt gaaggtgaaa   2640

ctgaaacaca aggaaaagga gaagaatgtg aagatgaaaa tgaagcagaa ggaaaaggag   2700

acaatgaagg tgaagatgag ggtgaaatcc acgcagaaga tggtgaaatg aaaggtaatg   2760

aaggtgaaac tgaaagccag gaactcagtg ctgaaaatca cggtgaagcc aaaaatgatg   2820

agaaaggtgt agaagatgga gggggaagtg atggagggga tagcgaagag gaggaagagg   2880

aggaggaaga gcaggaggaa gaggaggagg aggaagagca ggaggaagag gaggaggagg   2940

aggaggaaga ggaggagaag ggaaatgaag agcctctgtc cctggactgg cctgaaacca   3000

ggcagaagca ggccatttac ctcttccttc tgcccatcgt gttcccactg tggctgacag   3060

tccccgacgt ccgaaggcag gagtctagga agttttttgt tttcaccttc ctgggatcta   3120

tcatgtggat agccatgttc tcatacctca tggtgtggtg ggctcaccag gttggtgaaa   3180

caatagggat ttctgaagag atcatgggcc tgacaatcct tgcagcaggc acatcaattc   3240

ctgacctcat caccagtgtg attgtcgctc gaaaaggcct gggagacatg gctgtgtcaa   3300

gctctgtggg cagtaacata tttgatatca ctgtgggctt gcctgttcct tggttgcttt   3360

tctctcttat caatggatta cagccagttc cagtcagcag caatggcttg ttttgtgcaa   3420

ttgttttgct ttttctcatg cttctgtttg tgatctcttc aattgcgtca tgtaaatgga   3480

gaatgaacaa gatcctgggc ttcacaatgt tcctccttta ctttgtattc ctgataatca   3540

gtgtgatgtt agaagatcga atcatatcct gtcctgtatc tgtctgaatc agtcactctt   3600

gctcacaatg ggcatggatc agaagaccat gcagaagtta ctgtatctct tgtgacccta   3660

atgaaagaat gtatatgatc ctggaaagtg aactgggtga cctaggacct ctgatatgaa   3720

tgtgatctga gactaaagtt tgtccttgga aacacctgca gctcattgtg gattaagaac   3780

ctcacccctg gaggggtgga gtttctaccc ctgactcatg cagacatcta ttacatggag   3840

gcagtagaag gacccctgga gccagagggt tttctaaatg agataactgg gggcaaaggt   3900

tgggataggc gcacgagcta taagacaagc tcctacgctc actgttccct gatcattcca   3960

aaggctgctg gcccaaaaga tgcagatgtg gtctacatct cagccttcct gacctctgcc   4020

ccaaacacac gctgcaattt tgtctcctcc ttttctgttc aaattgtgag gttctatcag   4080

gtttgtaatc actgtagctt cagttattgg tgagtctaag gatccaaggc tacagaaaaa   4140

aaagaaatat aacaggaatt aatgatcatt ccacgttttg tagcccactg catctggata   4200

tataccagta tttttctttt tttttttttt gagacagagt ttggctcttg ttgcccaggc   4260

tggtgtgcaa tggcgtgatc tcggcacacc acaaccttca cctccccggt tcaagcaatt   4320

ctcctgcctc agcctgaagt cgtgatctgc ccgcctcggc ctcccaaagt gctgggatta   4380

caggcgtcag ccaccgcgcc tggcctatac cagtattttc tagtttaaag gaggactaca   4440

ttaactctta ttgttgtgtt tctgaaaagt gaaatttaaa aagcagcctg aaaaataaaa   4500

atttataatt tgcccttgaa ttggaaggaa tggagattag ggaaggaaaa ctactctaga   4560

ggccatttaa aagtatgtat ttattagaac atcgaaattc gtgttgtctc catcagtggt   4620

caccttgagg gattagacat tctaatggaa tgtcctggct ccaccctcca gcatgttctc   4680

acccaacaat gacagttgag tggagtggga agggaagtca ttctaaagag tccaaagtca   4740

gtagcgccac atctggttta taaagtaaga gatccagtgg acaatgctat ttttgtatgc   4800

caacctagat aggattataa agcaagactg atttcttctg tggtttatga atgatcttaa   4860

ggtaattaca aaagggaaat tccaagaatg cataacacaa tgacaacatg gtgagaaaag   4920

tgcagtacta cttccaaggt ggctagtgta aaggacactt gagtttttaa aactgtggtt   4980

aaatgtttta tgtggaattt gatgagtttg tatattaaat accactgctt gctgctttta   5040

ctagaatcaa gttaagggac acgttagaaa tagaacagct taatatcact ggcttcagag   5100

caaaatgagc tcgggtgact gcagattatg atggtaaata tggctttaat tacaaacatg   5160

aggaatgatt cactgaagat gaaaagatag gacggatgtg atatgaaaaa aacccaaaca   5220

ttttggcatt gaatgatggc taaggtgttc caagtattcc atcttttaag atgaattgct   5280

taattaattg cctcgctacc ccaggattct cattctttgg aaataatttt tattaaattt   5340

caataaactg tgaatcccaa tggtatttta cttt                               5374


<210>  1754
<211>  1099
<212>  PRT
<213>  Homosapiens

<400>  1754

Met Gly Lys Leu Ile Arg Met Gly Pro Gln Glu Arg Trp Leu Leu Arg 
1               5                   10                  15      


Thr Lys Arg Leu His Trp Ser Arg Leu Leu Phe Leu Leu Gly Met Leu 
            20                  25                  30          


Ile Ile Gly Ser Thr Tyr Gln His Leu Arg Arg Pro Arg Gly Leu Ser 
        35                  40                  45              


Ser Leu Trp Ala Ala Val Ser Ser His Gln Pro Ile Lys Leu Ala Ser 
    50                  55                  60                  


Arg Asp Leu Ser Ser Glu Glu Met Met Met Met Ser Ser Ser Pro Ser 
65                  70                  75                  80  


Lys Pro Ser Ser Glu Met Gly Gly Lys Met Leu Val Pro Gln Ala Ser 
                85                  90                  95      


Val Gly Ser Asp Glu Ala Thr Leu Ser Met Thr Val Glu Asn Ile Pro 
            100                 105                 110         


Ser Met Pro Lys Arg Thr Ala Lys Met Ile Pro Thr Thr Thr Lys Asn 
        115                 120                 125             


Asn Tyr Ser Pro Thr Ala Ala Gly Thr Glu Arg Arg Lys Glu Asp Thr 
    130                 135                 140                 


Pro Thr Ser Ser Arg Thr Leu Thr Tyr Tyr Thr Ser Thr Ser Ser Arg 
145                 150                 155                 160 


Gln Ile Val Lys Lys Tyr Thr Pro Thr Pro Arg Gly Glu Met Lys Ser 
                165                 170                 175     


Tyr Ser Pro Thr Gln Val Arg Glu Lys Val Lys Tyr Thr Pro Ser Pro 
            180                 185                 190         


Arg Gly Arg Arg Val Gly Thr Tyr Val Pro Ser Thr Phe Met Thr Met 
        195                 200                 205             


Glu Thr Ser His Ala Ile Thr Pro Arg Thr Thr Val Lys Asp Ser Asp 
    210                 215                 220                 


Ile Thr Ala Thr Tyr Lys Ile Leu Glu Thr Asn Ser Leu Lys Arg Ile 
225                 230                 235                 240 


Met Glu Glu Thr Thr Pro Thr Thr Leu Lys Gly Met Phe Asp Ser Thr 
                245                 250                 255     


Pro Thr Phe Leu Thr His Glu Val Glu Ala Asn Val Leu Thr Ser Pro 
            260                 265                 270         


Arg Ser Val Met Glu Lys Asn Asn Leu Phe Pro Pro Arg Arg Val Glu 
        275                 280                 285             


Ser Asn Ser Ser Ala His Pro Trp Gly Leu Val Gly Lys Ser Asn Pro 
    290                 295                 300                 


Lys Thr Pro Gln Gly Thr Val Leu Leu His Thr Pro Ala Thr Ser Glu 
305                 310                 315                 320 


Gly Gln Val Thr Ile Ser Thr Met Thr Gly Ser Ser Pro Ala Glu Thr 
                325                 330                 335     


Lys Ala Phe Thr Ala Ala Trp Ser Leu Arg Asn Pro Ser Pro Arg Thr 
            340                 345                 350         


Ser Val Ser Ala Ile Lys Thr Ala Pro Ala Ile Val Trp Arg Leu Ala 
        355                 360                 365             


Lys Lys Pro Ser Thr Ala Pro Ser Thr Ser Thr Thr Pro Thr Val Arg 
    370                 375                 380                 


Ala Lys Leu Thr Met Gln Val His His Cys Val Val Val Lys Pro Thr 
385                 390                 395                 400 


Pro Ala Met Leu Thr Thr Pro Ser Pro Ser Leu Thr Thr Ala Leu Leu 
                405                 410                 415     


Pro Glu Glu Leu Ser Pro Ser Pro Ser Val Leu Pro Pro Ser Leu Pro 
            420                 425                 430         


Asp Leu His Pro Lys Gly Glu Tyr Pro Pro Asp Leu Phe Ser Val Glu 
        435                 440                 445             


Glu Arg Arg Gln Gly Trp Val Val Leu His Val Phe Gly Met Met Tyr 
    450                 455                 460                 


Val Phe Val Ala Leu Ala Ile Val Cys Asp Glu Tyr Phe Val Pro Ala 
465                 470                 475                 480 


Leu Gly Val Ile Thr Asp Lys Leu Gln Ile Ser Glu Asp Val Ala Gly 
                485                 490                 495     


Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser 
            500                 505                 510         


Leu Ile Gly Val Phe Ile Ser His Ser Asn Val Gly Ile Gly Thr Ile 
        515                 520                 525             


Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Thr Cys Ser 
    530                 535                 540                 


Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg 
545                 550                 555                 560 


Asp Val Ser Phe Tyr Ile Leu Asp Leu Ile Met Leu Ile Leu Phe Phe 
                565                 570                 575     


Leu Asp Ser Leu Ile Ala Trp Trp Glu Ser Leu Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Ala Phe Tyr Val Phe Thr Met Lys Trp Asn Lys His Ile Glu Val 
        595                 600                 605             


Trp Val Lys Glu Gln Leu Ser Arg Arg Pro Val Ala Lys Val Met Ala 
    610                 615                 620                 


Leu Glu Asp Leu Ser Lys Pro Gly Asp Gly Ala Ile Ala Val Asp Glu 
625                 630                 635                 640 


Leu Gln Asp Asn Lys Lys Leu Lys Leu Pro Ser Leu Leu Thr Arg Gly 
                645                 650                 655     


Ser Ser Ser Thr Ser Leu His Asn Ser Thr Ile Arg Ser Thr Ile Tyr 
            660                 665                 670         


Gln Leu Met Leu His Ser Leu Asp Pro Leu Arg Glu Val Arg Leu Ala 
        675                 680                 685             


Lys Glu Lys Glu Glu Glu Ser Leu Asn Gln Gly Ala Arg Ala Gln Pro 
    690                 695                 700                 


Gln Ala Lys Ala Glu Ser Lys Pro Glu Glu Glu Glu Pro Ala Lys Leu 
705                 710                 715                 720 


Pro Ala Val Thr Val Thr Pro Ala Pro Val Pro Asp Ile Lys Gly Asp 
                725                 730                 735     


Gln Lys Glu Asn Pro Gly Gly Gln Glu Asp Val Ala Glu Ala Glu Ser 
            740                 745                 750         


Thr Gly Glu Met Pro Gly Glu Glu Gly Glu Thr Ala Gly Glu Gly Glu 
        755                 760                 765             


Thr Glu Glu Lys Ser Gly Gly Glu Thr Gln Pro Glu Gly Glu Gly Glu 
    770                 775                 780                 


Thr Glu Thr Gln Gly Lys Gly Glu Glu Cys Glu Asp Glu Asn Glu Ala 
785                 790                 795                 800 


Glu Gly Lys Gly Asp Asn Glu Gly Glu Asp Glu Gly Glu Ile His Ala 
                805                 810                 815     


Glu Asp Gly Glu Met Lys Gly Asn Glu Gly Glu Thr Glu Ser Gln Glu 
            820                 825                 830         


Leu Ser Ala Glu Asn His Gly Glu Ala Lys Asn Asp Glu Lys Gly Val 
        835                 840                 845             


Glu Asp Gly Gly Gly Ser Asp Gly Gly Asp Ser Glu Glu Glu Glu Glu 
    850                 855                 860                 


Glu Glu Glu Glu Gln Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu 
865                 870                 875                 880 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Gly Asn Glu Glu Pro 
                885                 890                 895     


Leu Ser Leu Asp Trp Pro Glu Thr Arg Gln Lys Gln Ala Ile Tyr Leu 
            900                 905                 910         


Phe Leu Leu Pro Ile Val Phe Pro Leu Trp Leu Thr Val Pro Asp Val 
        915                 920                 925             


Arg Arg Gln Glu Ser Arg Lys Phe Phe Val Phe Thr Phe Leu Gly Ser 
    930                 935                 940                 


Ile Met Trp Ile Ala Met Phe Ser Tyr Leu Met Val Trp Trp Ala His 
945                 950                 955                 960 


Gln Val Gly Glu Thr Ile Gly Ile Ser Glu Glu Ile Met Gly Leu Thr 
                965                 970                 975     


Ile Leu Ala Ala Gly Thr Ser Ile Pro Asp Leu Ile Thr Ser Val Ile 
            980                 985                 990         


Val Ala Arg Lys Gly Leu Gly Asp  Met Ala Val Ser Ser  Ser Val Gly 
        995                 1000                 1005             


Ser Asn  Ile Phe Asp Ile Thr  Val Gly Leu Pro Val  Pro Trp Leu 
    1010                 1015                 1020             


Leu Phe  Ser Leu Ile Asn Gly  Leu Gln Pro Val Pro  Val Ser Ser 
    1025                 1030                 1035             


Asn Gly  Leu Phe Cys Ala Ile  Val Leu Leu Phe Leu  Met Leu Leu 
    1040                 1045                 1050             


Phe Val  Ile Ser Ser Ile Ala  Ser Cys Lys Trp Arg  Met Asn Lys 
    1055                 1060                 1065             


Ile Leu  Gly Phe Thr Met Phe  Leu Leu Tyr Phe Val  Phe Leu Ile 
    1070                 1075                 1080             


Ile Ser  Val Met Leu Glu Asp  Arg Ile Ile Ser Cys  Pro Val Ser 
    1085                 1090                 1095             


Val 
    


<210>  1755
<211>  6585
<212>  DNA
<213>  Homosapiens

<400>  1755
ggagaaagag gcggaggcag tggcggccgc gaggggaggg ggagtcccgt ctgactgaga     60

cggcaggcct gggcgggcgg gcgggggtgc cgcgaagggc ggagcgccgg gctggggatg    120

agctaagcgg gctcagagcg ccgcggcatt cagcccctcg tgttccgcta ccgcgcgtgc    180

gggattccgg cgccgctctc cgagctcgat ccgctgctcg cacgggagcc agctgggtgt    240

tatttctcaa actctgaggc tgcggagttc acacattgaa atctgtcatc tttttcagag    300

agaaactttc ggtaatgtat gtaaccttct gtaatggaag atgattgaag acaaggggcc    360

tcgtgttgct gactactttg ttgtagcagg attaactgat gtttcaaagc ctctagaaga    420

agaaattcac ttcaatgatg cttgtcataa agtagctaaa ccaaaagaac ctattacaga    480

tgtttcagtt attatcaaat ctcttgggga ggaagtccca caggattata tctgtattga    540

tgttacccca actggattgt cagctgatct taataatgga agtcttgtgg ggccacagat    600

ttacctttgc tatagaagag gaagagataa gcctccactt acagatctgg gggttttata    660

tgactggaaa gaaagattga aacagggttg tgaaattatt cagagtactc cctatgggcg    720

ccccgcaaat attagtggga gtacctcatc acaaagaatt tatatcactt accgaagagc    780

ctctgaaaac atgactcaga atacgttggc tgtcactgac atatgtatta ttatacccag    840

taaaggagaa agcccaccac acacgttctg caaagtcgac aagaatctca ataacagtat    900

gtggggatca gcagtatact tgtgttataa aaaatcggtg gcaaagacga acactgtatc    960

ttacaaagct ggcctaattt gtagatatcc tcaagaagat tatgagtcat tctcactacc   1020

ggaatctgtt cctctatttt gtttaccaat gggtgcaacc attgaatgtt ggccatcaaa   1080

tagcaaatac cctctgcctg tattttctac ttttgtttta actggagcct cagctgaaaa   1140

ggtttatggt gctgctattc agttttatga accatactct gaggagaatc tcacagaaaa   1200

gcagagactt cttttgggtt taacatcagc agatgggaag tctgatagtt ccaaaacaat   1260

tcatactaac aaatgcatct gtcttctttc tcactggcct ttttttgatg cattcaggaa   1320

gtttctgact tttctgtatc gttattccat ctctgggcct catgtccttc caattgagaa   1380

gcatatttct cattttatgc ataaagttcc ttttccatct cctcagagac cacggatttt   1440

agttcagtta tcaccacatg ataatctgat tctcagtcag cctgtgtctt cacctcttcc   1500

actaagtggt ggcaagtttt caacactact gcagaattta ggccctgaaa atgctgtgac   1560

actactggtg tttgcagtaa cagaacataa aattcttatc cattccctac ggccatccgt   1620

gcttactagt gtgacagaag cattagtgtc tatgattttc cctttccact ggccatgccc   1680

gtatgttcct ctctgcccac tggctttagc agatgtcttg agtgcaccat gtccattcat   1740

agtagggatt gattcaagat actttgatct ctatgatcct ccaccagatg tcagttgtgt   1800

tgatgtagat accaacacta tttctcagat tggtgacaag aaaaatgtag cctggaagat   1860

acttccaaag aagccatgta aaaatctgat gaacacactg aataatttgc atcagcaatt   1920

ggcaaaattg cagcagagac cgagagatga tggactcatg gatttagcaa taaatgacta   1980

tgattttaat tctggaaaga ggttgcacat gatagatttg gaaatccaag aggcattttt   2040

gtttttcatg gcctctattt taaaaggtta cagatcatac ttaaggccaa taacacaagc   2100

cccatctgag acagccacag atgcagcctc tctctttgcc ctacaagctt tcttaagaag   2160

ccgggaccgg tcacatcaaa aattctataa catgatgacc aaaacacaaa tgtttattcg   2220

cttcattgaa gaatgttctt ttgttagtga caaagatgca agcctggcat tttttgatga   2280

ttgtgtagat aaagtggata tggacaagag cggtgaagta cgacttatag aactggatga   2340

atctttcaaa agtgaacaca ctgtttttgt aacaccacct gagatccccc acctacccaa   2400

tggtgaagaa ccccctttac agtacagcta taatggattt ccagttctta ggaacaattt   2460

atttgaaaga cctgaaggat ttctacaagc aaagaagaac aaattgcctt caaaatcaag   2520

tagtcctaat agccctttgc ccatgttcag aagaacaaaa caggaaatta aatcagccca   2580

taaaattgca aagaggtact cttccatccc tcagatgtgg tctaggtgtc tactgcgcca   2640

ctgttatgga ctgtggttta tttgtctccc agcttatgtg aaagtctgtc attcaaaagt   2700

cagggctctg aaaacagcat atgatgtgct taaaaaaatg cagtcaaaga agatggatcc   2760

acctgatgag gtatgctacc gcattcttat gcaactctgt ggacaatatg atcagccagt   2820

gcttgcagtt cgagtgcttt ttgaaatgca gaaagctggt attgacccca atgccattac   2880

ttatggttat tataataagg ctgttttgga aagtacctgg ccttcaagaa gtcgtagtgg   2940

ctattttctt tggacaaaag taagaaatgt tgttttagga gtaacacagt tcaaaagagc   3000

tttaaagaag catgcacact tatcacaaac aactctctca ggtggccagt ctgatcttgg   3060

atataattca ttatctaaag atgaagttag aagaggggat acatctactg aagacattca   3120

agaagaaaaa gataaaaaag ggagtgattg tagttccttg tcagagagtg agagtacaaa   3180

aggaagtgct gattgccttc ctaagctcag ttatcaaaat tcttccagta tcgttcgcct   3240

cactggtaca agtaacaaca gtgctggtaa aatatcagga gaaagcatgg gtaaggaaag   3300

cacacctgag ctgctcttaa tatcatctct tgaagataca aatgaaacac gaaacattca   3360

aagtagatgc ttcaggaaaa gacataaaag tgacaatgaa actaatttgc agcagcaagt   3420

ggtctgggga aatagaaacc gtaatcttag tggaggggta ctgatgggat ttatgctcaa   3480

tagaattaac caggaagcaa cccctggaga tatagttgaa aaattgggag ctgatgcaaa   3540

aattctttca aatgttatct caaaaagcac gagaccaaat actcttgata ttgggaagcc   3600

acctttaaga tcaaaaagag acagtctaga aaaggaatct agtgatgatg atacaccttt   3660

tgatggttct aactatttgg cagataaagt ggattctcct gttatttttg acttagaaga   3720

cttagacagt gaaacagatg tatcaaaagc aggatgtgtt gctacacaaa atcccaagag   3780

gattcaacgt atgaacagca gcttttcagt aaaacctttt gaaaaaactg atgtcgcaac   3840

aggatttgat cccctctctc ttttggttgc tgagactgaa cagcagcaaa aagaagaaga   3900

ggaggaggat gaagatgata gcaaaagcat ttcaacacca tctgctaggc gtgatttagc   3960

tgaagaaatt gtgatgtata tgaataacat gagcagtcct ttgacaagtc gtacaccaag   4020

cattgattta caacgggcat gtgatgataa attaaataag aaaagtccac cattggtcaa   4080

ggcatgcaga agatctagtc tgcctcctaa ttctcctaag ccagtgagac ttaccaaatc   4140

taaaagttac acaaaaagtg aggagaaacc aagggataga ctttggtctt ctccagcctt   4200

ctcacctact tgcccattta gggaagaatc tcaggataca ttaacccact catcaccttc   4260

atttaactta gatacactac tagtacctaa actagatgtt ctaagaaaca gtatgttcac   4320

tgctggaaaa ggagttgcag agaaagcaag caaatggtat tcaagattca ccatgtacac   4380

cacatcatct aaggatcaaa gttctgatcg taccagtctt tcttcagtgg gagcccagga   4440

ttctgaatct acctctttaa cagatgaaga tgtctgccat gagttggaag gacctatctc   4500

ctctcaagag accagtgcta cttcagggac taagagaatt gatctcagcc gaataagcct   4560

ggaaagttct gcatccttgg aaggatctct gtcgaagttt gccttacctg ggaaatcaga   4620

agtgacatct tccttcaacg cgagtaatac aaatatcttc cagaactatg caatggaggt   4680

tctcatctca agttgctctc ggtgtagaac ttgtgattgt cttgtccatg atgaggaaat   4740

catggctggc tggacagcag atgattcaaa tctcaatact acatgcccat tctgtggcaa   4800

tatcttctta ccctttctga atatagaaat aagagattta agacgacctg gaagatactt   4860

tctaaagtca agcccatcaa cagaaaatat gcactttcca tcctccattt caagtcagac   4920

gaggcagtct tgcatttcaa catcagcctc tggtcttgac acatctgctc tctctgttca   4980

agggaatttt gatctaaata gcaaatctaa actgcaggaa aatttttgca cccgaagtat   5040

tcagatccct gctaatagat caaaaacagc tatgtctaaa tgtccaatat ttccaatggc   5100

caggagtatt agtacttctg gccccttgga taaggaagat actggaagac agaagctcat   5160

ttctacaggc agcctgccag ctactttaca aggagctaca gattctttag gtttagaatg   5220

gcaccttcca agtcccgatc ctgtcactgt tccgtatctt agtcctttag tggtatggaa   5280

agaacttgaa agcttattgg aaaatgaagg tgatcatgca ataacagtag cagactttgt   5340

ggaccatcat ccaattgttt tttggaacct ggtatggtat ttcagacgtc ttgacttgcc   5400

cagtaactta cctggattga ttctttcttc tgagcactgt aacaagtatt caaagattcc   5460

ccgccactgt atgtctgaag atagcaaata tgttttaata caaatgttat gggacaatat   5520

gaagttacat caggatccgg gacagccctt gtacattctc tggaatgcac acacccaaaa   5580

atatccaatg gtccatttat tgcaaaaaag tgataactca tttaaccagg aactgttgaa   5640

aagtatggta aaaagcatta aaatgaatga tgtctatgga ccaatgagtc agattttaga   5700

gacactgaat aagtgtccac attttaaaag acagaggagt ttatacagag aaatactatt   5760

tctctcactt gtggcactgg gaagagaaaa cattgatata gatgcttttg ataaagagta   5820

caagatggca tacgatcgtc tcacacctag tcaagtcaag agtacacaca actgtgatag   5880

accaccaagt acaggggtga tggaatgtcg aaaaaccttt ggagaacctt atctttaaga   5940

tgtatttgta tgtgtaaaca ttcaatgtat attgtatagt cagtgtataa aataacactt   6000

ttagactcta aatatttttt cttcaatttt tgaaaataca atttgtaaat ggttcaaaag   6060

actcagacag cttatgtaca gaatgtttga agaagagaat agtgacaagt ggggagaaag   6120

ccactttgtt tctcatttct tttttcttct tctttaactc ccctgtaata ggaaataaag   6180

tatttttgtg atgaggaaat ccctaaacaa aattagttgc cataaaatat gacaactgct   6240

ttatggtttc ttttggaaga gacagattga aaaatcatga atggaatcta aacagaaatg   6300

tcagatgaac gtatttcctg ttttcataga ctattcaaat gttttgacca tgaagttgta   6360

ttatacatat tttaaattgt ttatagtaag ttgatatttt tttaattttt aaatttaata   6420

tagcaaactt aaaatgaatt taaacttaag caagcaagcg tgtattttcc ttgtctgctg   6480

ctatttgaag taattagtac agctgcagat ctctctgtgt atatctatct atatatatat   6540

tttttattac ttgggagaat gaattttaaa atgtcagtgc tagtg                   6585


<210>  1756
<211>  1865
<212>  PRT
<213>  Homosapiens

<400>  1756

Met Ile Glu Asp Lys Gly Pro Arg Val Ala Asp Tyr Phe Val Val Ala 
1               5                   10                  15      


Gly Leu Thr Asp Val Ser Lys Pro Leu Glu Glu Glu Ile His Phe Asn 
            20                  25                  30          


Asp Ala Cys His Lys Val Ala Lys Pro Lys Glu Pro Ile Thr Asp Val 
        35                  40                  45              


Ser Val Ile Ile Lys Ser Leu Gly Glu Glu Val Pro Gln Asp Tyr Ile 
    50                  55                  60                  


Cys Ile Asp Val Thr Pro Thr Gly Leu Ser Ala Asp Leu Asn Asn Gly 
65                  70                  75                  80  


Ser Leu Val Gly Pro Gln Ile Tyr Leu Cys Tyr Arg Arg Gly Arg Asp 
                85                  90                  95      


Lys Pro Pro Leu Thr Asp Leu Gly Val Leu Tyr Asp Trp Lys Glu Arg 
            100                 105                 110         


Leu Lys Gln Gly Cys Glu Ile Ile Gln Ser Thr Pro Tyr Gly Arg Pro 
        115                 120                 125             


Ala Asn Ile Ser Gly Ser Thr Ser Ser Gln Arg Ile Tyr Ile Thr Tyr 
    130                 135                 140                 


Arg Arg Ala Ser Glu Asn Met Thr Gln Asn Thr Leu Ala Val Thr Asp 
145                 150                 155                 160 


Ile Cys Ile Ile Ile Pro Ser Lys Gly Glu Ser Pro Pro His Thr Phe 
                165                 170                 175     


Cys Lys Val Asp Lys Asn Leu Asn Asn Ser Met Trp Gly Ser Ala Val 
            180                 185                 190         


Tyr Leu Cys Tyr Lys Lys Ser Val Ala Lys Thr Asn Thr Val Ser Tyr 
        195                 200                 205             


Lys Ala Gly Leu Ile Cys Arg Tyr Pro Gln Glu Asp Tyr Glu Ser Phe 
    210                 215                 220                 


Ser Leu Pro Glu Ser Val Pro Leu Phe Cys Leu Pro Met Gly Ala Thr 
225                 230                 235                 240 


Ile Glu Cys Trp Pro Ser Asn Ser Lys Tyr Pro Leu Pro Val Phe Ser 
                245                 250                 255     


Thr Phe Val Leu Thr Gly Ala Ser Ala Glu Lys Val Tyr Gly Ala Ala 
            260                 265                 270         


Ile Gln Phe Tyr Glu Pro Tyr Ser Glu Glu Asn Leu Thr Glu Lys Gln 
        275                 280                 285             


Arg Leu Leu Leu Gly Leu Thr Ser Ala Asp Gly Lys Ser Asp Ser Ser 
    290                 295                 300                 


Lys Thr Ile His Thr Asn Lys Cys Ile Cys Leu Leu Ser His Trp Pro 
305                 310                 315                 320 


Phe Phe Asp Ala Phe Arg Lys Phe Leu Thr Phe Leu Tyr Arg Tyr Ser 
                325                 330                 335     


Ile Ser Gly Pro His Val Leu Pro Ile Glu Lys His Ile Ser His Phe 
            340                 345                 350         


Met His Lys Val Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val 
        355                 360                 365             


Gln Leu Ser Pro His Asp Asn Leu Ile Leu Ser Gln Pro Val Ser Ser 
    370                 375                 380                 


Pro Leu Pro Leu Ser Gly Gly Lys Phe Ser Thr Leu Leu Gln Asn Leu 
385                 390                 395                 400 


Gly Pro Glu Asn Ala Val Thr Leu Leu Val Phe Ala Val Thr Glu His 
                405                 410                 415     


Lys Ile Leu Ile His Ser Leu Arg Pro Ser Val Leu Thr Ser Val Thr 
            420                 425                 430         


Glu Ala Leu Val Ser Met Ile Phe Pro Phe His Trp Pro Cys Pro Tyr 
        435                 440                 445             


Val Pro Leu Cys Pro Leu Ala Leu Ala Asp Val Leu Ser Ala Pro Cys 
    450                 455                 460                 


Pro Phe Ile Val Gly Ile Asp Ser Arg Tyr Phe Asp Leu Tyr Asp Pro 
465                 470                 475                 480 


Pro Pro Asp Val Ser Cys Val Asp Val Asp Thr Asn Thr Ile Ser Gln 
                485                 490                 495     


Ile Gly Asp Lys Lys Asn Val Ala Trp Lys Ile Leu Pro Lys Lys Pro 
            500                 505                 510         


Cys Lys Asn Leu Met Asn Thr Leu Asn Asn Leu His Gln Gln Leu Ala 
        515                 520                 525             


Lys Leu Gln Gln Arg Pro Arg Asp Asp Gly Leu Met Asp Leu Ala Ile 
    530                 535                 540                 


Asn Asp Tyr Asp Phe Asn Ser Gly Lys Arg Leu His Met Ile Asp Leu 
545                 550                 555                 560 


Glu Ile Gln Glu Ala Phe Leu Phe Phe Met Ala Ser Ile Leu Lys Gly 
                565                 570                 575     


Tyr Arg Ser Tyr Leu Arg Pro Ile Thr Gln Ala Pro Ser Glu Thr Ala 
            580                 585                 590         


Thr Asp Ala Ala Ser Leu Phe Ala Leu Gln Ala Phe Leu Arg Ser Arg 
        595                 600                 605             


Asp Arg Ser His Gln Lys Phe Tyr Asn Met Met Thr Lys Thr Gln Met 
    610                 615                 620                 


Phe Ile Arg Phe Ile Glu Glu Cys Ser Phe Val Ser Asp Lys Asp Ala 
625                 630                 635                 640 


Ser Leu Ala Phe Phe Asp Asp Cys Val Asp Lys Val Asp Met Asp Lys 
                645                 650                 655     


Ser Gly Glu Val Arg Leu Ile Glu Leu Asp Glu Ser Phe Lys Ser Glu 
            660                 665                 670         


His Thr Val Phe Val Thr Pro Pro Glu Ile Pro His Leu Pro Asn Gly 
        675                 680                 685             


Glu Glu Pro Pro Leu Gln Tyr Ser Tyr Asn Gly Phe Pro Val Leu Arg 
    690                 695                 700                 


Asn Asn Leu Phe Glu Arg Pro Glu Gly Phe Leu Gln Ala Lys Lys Asn 
705                 710                 715                 720 


Lys Leu Pro Ser Lys Ser Ser Ser Pro Asn Ser Pro Leu Pro Met Phe 
                725                 730                 735     


Arg Arg Thr Lys Gln Glu Ile Lys Ser Ala His Lys Ile Ala Lys Arg 
            740                 745                 750         


Tyr Ser Ser Ile Pro Gln Met Trp Ser Arg Cys Leu Leu Arg His Cys 
        755                 760                 765             


Tyr Gly Leu Trp Phe Ile Cys Leu Pro Ala Tyr Val Lys Val Cys His 
    770                 775                 780                 


Ser Lys Val Arg Ala Leu Lys Thr Ala Tyr Asp Val Leu Lys Lys Met 
785                 790                 795                 800 


Gln Ser Lys Lys Met Asp Pro Pro Asp Glu Val Cys Tyr Arg Ile Leu 
                805                 810                 815     


Met Gln Leu Cys Gly Gln Tyr Asp Gln Pro Val Leu Ala Val Arg Val 
            820                 825                 830         


Leu Phe Glu Met Gln Lys Ala Gly Ile Asp Pro Asn Ala Ile Thr Tyr 
        835                 840                 845             


Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Thr Trp Pro Ser Arg Ser 
    850                 855                 860                 


Arg Ser Gly Tyr Phe Leu Trp Thr Lys Val Arg Asn Val Val Leu Gly 
865                 870                 875                 880 


Val Thr Gln Phe Lys Arg Ala Leu Lys Lys His Ala His Leu Ser Gln 
                885                 890                 895     


Thr Thr Leu Ser Gly Gly Gln Ser Asp Leu Gly Tyr Asn Ser Leu Ser 
            900                 905                 910         


Lys Asp Glu Val Arg Arg Gly Asp Thr Ser Thr Glu Asp Ile Gln Glu 
        915                 920                 925             


Glu Lys Asp Lys Lys Gly Ser Asp Cys Ser Ser Leu Ser Glu Ser Glu 
    930                 935                 940                 


Ser Thr Lys Gly Ser Ala Asp Cys Leu Pro Lys Leu Ser Tyr Gln Asn 
945                 950                 955                 960 


Ser Ser Ser Ile Val Arg Leu Thr Gly Thr Ser Asn Asn Ser Ala Gly 
                965                 970                 975     


Lys Ile Ser Gly Glu Ser Met Gly Lys Glu Ser Thr Pro Glu Leu Leu 
            980                 985                 990         


Leu Ile Ser Ser Leu Glu Asp Thr  Asn Glu Thr Arg Asn  Ile Gln Ser 
        995                 1000                 1005             


Arg Cys  Phe Arg Lys Arg His  Lys Ser Asp Asn Glu  Thr Asn Leu 
    1010                 1015                 1020             


Gln Gln  Gln Val Val Trp Gly  Asn Arg Asn Arg Asn  Leu Ser Gly 
    1025                 1030                 1035             


Gly Val  Leu Met Gly Phe Met  Leu Asn Arg Ile Asn  Gln Glu Ala 
    1040                 1045                 1050             


Thr Pro  Gly Asp Ile Val Glu  Lys Leu Gly Ala Asp  Ala Lys Ile 
    1055                 1060                 1065             


Leu Ser  Asn Val Ile Ser Lys  Ser Thr Arg Pro Asn  Thr Leu Asp 
    1070                 1075                 1080             


Ile Gly  Lys Pro Pro Leu Arg  Ser Lys Arg Asp Ser  Leu Glu Lys 
    1085                 1090                 1095             


Glu Ser  Ser Asp Asp Asp Thr  Pro Phe Asp Gly Ser  Asn Tyr Leu 
    1100                 1105                 1110             


Ala Asp  Lys Val Asp Ser Pro  Val Ile Phe Asp Leu  Glu Asp Leu 
    1115                 1120                 1125             


Asp Ser  Glu Thr Asp Val Ser  Lys Ala Gly Cys Val  Ala Thr Gln 
    1130                 1135                 1140             


Asn Pro  Lys Arg Ile Gln Arg  Met Asn Ser Ser Phe  Ser Val Lys 
    1145                 1150                 1155             


Pro Phe  Glu Lys Thr Asp Val  Ala Thr Gly Phe Asp  Pro Leu Ser 
    1160                 1165                 1170             


Leu Leu  Val Ala Glu Thr Glu  Gln Gln Gln Lys Glu  Glu Glu Glu 
    1175                 1180                 1185             


Glu Asp  Glu Asp Asp Ser Lys  Ser Ile Ser Thr Pro  Ser Ala Arg 
    1190                 1195                 1200             


Arg Asp  Leu Ala Glu Glu Ile  Val Met Tyr Met Asn  Asn Met Ser 
    1205                 1210                 1215             


Ser Pro  Leu Thr Ser Arg Thr  Pro Ser Ile Asp Leu  Gln Arg Ala 
    1220                 1225                 1230             


Cys Asp  Asp Lys Leu Asn Lys  Lys Ser Pro Pro Leu  Val Lys Ala 
    1235                 1240                 1245             


Cys Arg  Arg Ser Ser Leu Pro  Pro Asn Ser Pro Lys  Pro Val Arg 
    1250                 1255                 1260             


Leu Thr  Lys Ser Lys Ser Tyr  Thr Lys Ser Glu Glu  Lys Pro Arg 
    1265                 1270                 1275             


Asp Arg  Leu Trp Ser Ser Pro  Ala Phe Ser Pro Thr  Cys Pro Phe 
    1280                 1285                 1290             


Arg Glu  Glu Ser Gln Asp Thr  Leu Thr His Ser Ser  Pro Ser Phe 
    1295                 1300                 1305             


Asn Leu  Asp Thr Leu Leu Val  Pro Lys Leu Asp Val  Leu Arg Asn 
    1310                 1315                 1320             


Ser Met  Phe Thr Ala Gly Lys  Gly Val Ala Glu Lys  Ala Ser Lys 
    1325                 1330                 1335             


Trp Tyr  Ser Arg Phe Thr Met  Tyr Thr Thr Ser Ser  Lys Asp Gln 
    1340                 1345                 1350             


Ser Ser  Asp Arg Thr Ser Leu  Ser Ser Val Gly Ala  Gln Asp Ser 
    1355                 1360                 1365             


Glu Ser  Thr Ser Leu Thr Asp  Glu Asp Val Cys His  Glu Leu Glu 
    1370                 1375                 1380             


Gly Pro  Ile Ser Ser Gln Glu  Thr Ser Ala Thr Ser  Gly Thr Lys 
    1385                 1390                 1395             


Arg Ile  Asp Leu Ser Arg Ile  Ser Leu Glu Ser Ser  Ala Ser Leu 
    1400                 1405                 1410             


Glu Gly  Ser Leu Ser Lys Phe  Ala Leu Pro Gly Lys  Ser Glu Val 
    1415                 1420                 1425             


Thr Ser  Ser Phe Asn Ala Ser  Asn Thr Asn Ile Phe  Gln Asn Tyr 
    1430                 1435                 1440             


Ala Met  Glu Val Leu Ile Ser  Ser Cys Ser Arg Cys  Arg Thr Cys 
    1445                 1450                 1455             


Asp Cys  Leu Val His Asp Glu  Glu Ile Met Ala Gly  Trp Thr Ala 
    1460                 1465                 1470             


Asp Asp  Ser Asn Leu Asn Thr  Thr Cys Pro Phe Cys  Gly Asn Ile 
    1475                 1480                 1485             


Phe Leu  Pro Phe Leu Asn Ile  Glu Ile Arg Asp Leu  Arg Arg Pro 
    1490                 1495                 1500             


Gly Arg  Tyr Phe Leu Lys Ser  Ser Pro Ser Thr Glu  Asn Met His 
    1505                 1510                 1515             


Phe Pro  Ser Ser Ile Ser Ser  Gln Thr Arg Gln Ser  Cys Ile Ser 
    1520                 1525                 1530             


Thr Ser  Ala Ser Gly Leu Asp  Thr Ser Ala Leu Ser  Val Gln Gly 
    1535                 1540                 1545             


Asn Phe  Asp Leu Asn Ser Lys  Ser Lys Leu Gln Glu  Asn Phe Cys 
    1550                 1555                 1560             


Thr Arg  Ser Ile Gln Ile Pro  Ala Asn Arg Ser Lys  Thr Ala Met 
    1565                 1570                 1575             


Ser Lys  Cys Pro Ile Phe Pro  Met Ala Arg Ser Ile  Ser Thr Ser 
    1580                 1585                 1590             


Gly Pro  Leu Asp Lys Glu Asp  Thr Gly Arg Gln Lys  Leu Ile Ser 
    1595                 1600                 1605             


Thr Gly  Ser Leu Pro Ala Thr  Leu Gln Gly Ala Thr  Asp Ser Leu 
    1610                 1615                 1620             


Gly Leu  Glu Trp His Leu Pro  Ser Pro Asp Pro Val  Thr Val Pro 
    1625                 1630                 1635             


Tyr Leu  Ser Pro Leu Val Val  Trp Lys Glu Leu Glu  Ser Leu Leu 
    1640                 1645                 1650             


Glu Asn  Glu Gly Asp His Ala  Ile Thr Val Ala Asp  Phe Val Asp 
    1655                 1660                 1665             


His His  Pro Ile Val Phe Trp  Asn Leu Val Trp Tyr  Phe Arg Arg 
    1670                 1675                 1680             


Leu Asp  Leu Pro Ser Asn Leu  Pro Gly Leu Ile Leu  Ser Ser Glu 
    1685                 1690                 1695             


His Cys  Asn Lys Tyr Ser Lys  Ile Pro Arg His Cys  Met Ser Glu 
    1700                 1705                 1710             


Asp Ser  Lys Tyr Val Leu Ile  Gln Met Leu Trp Asp  Asn Met Lys 
    1715                 1720                 1725             


Leu His  Gln Asp Pro Gly Gln  Pro Leu Tyr Ile Leu  Trp Asn Ala 
    1730                 1735                 1740             


His Thr  Gln Lys Tyr Pro Met  Val His Leu Leu Gln  Lys Ser Asp 
    1745                 1750                 1755             


Asn Ser  Phe Asn Gln Glu Leu  Leu Lys Ser Met Val  Lys Ser Ile 
    1760                 1765                 1770             


Lys Met  Asn Asp Val Tyr Gly  Pro Met Ser Gln Ile  Leu Glu Thr 
    1775                 1780                 1785             


Leu Asn  Lys Cys Pro His Phe  Lys Arg Gln Arg Ser  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Ile  Leu Phe Leu Ser Leu  Val Ala Leu Gly Arg  Glu Asn Ile 
    1805                 1810                 1815             


Asp Ile  Asp Ala Phe Asp Lys  Glu Tyr Lys Met Ala  Tyr Asp Arg 
    1820                 1825                 1830             


Leu Thr  Pro Ser Gln Val Lys  Ser Thr His Asn Cys  Asp Arg Pro 
    1835                 1840                 1845             


Pro Ser  Thr Gly Val Met Glu  Cys Arg Lys Thr Phe  Gly Glu Pro 
    1850                 1855                 1860             


Tyr Leu  
    1865 


<210>  1757
<211>  2393
<212>  DNA
<213>  Homosapiens

<400>  1757
agcggcaggg aggggctctt cacccagtcc ggcagttgaa gctcggcgct cgggttaccc     60

ctgcagcgac gccccctggt cccacagata ccactgctgc tcccgccctt tcgctcctcg    120

gccgcgcaat gggcacccgc gacgacgagt acgactacct ctttaaagtt gtccttattg    180

gagattctgg tgttggaaag agtaatctcc tgtctcgatt tactcgaaat gagtttaatc    240

tggaaagcaa gagcaccatt ggagtagagt ttgcaacaag aagcatccag gttgatggaa    300

aaacaataaa ggcacagata tgggacacag cagggcaaga gcgatatcga gctataacat    360

cagcatatta tcgtggagct gtaggtgcct tattggttta tgacattgct aaacatctca    420

catatgaaaa tgtagagcga tggctgaaag aactgagaga tcatgctgat agtaacattg    480

ttatcatgct tgtgggcaat aagagtgatc tacgtcatct cagggcagtt cctacagatg    540

aagcaagagc ttttgcagaa aagaatggtt tgtcattcat tgaaacttcg gccctagact    600

ctacaaatgt agaagctgct tttcagacaa ttttaacaga gatttaccgc attgtttctc    660

agaagcaaat gtcagacaga cgcgaaaatg acatgtctcc aagcaacaat gtggttccta    720

ttcatgttcc accaaccact gaaaacaagc caaaggtgca gtgctgtcag aacatctaag    780

gcatttctct tctcccctag aaggctgtgt atagtccatt tcccaggtct gagatttaaa    840

tatatttgta attcttgtgt cacttttgtg ttttattact tcatacttat gaatttttcc    900

atgtcctaag tcttttgatt ttagctttat aaaatcatcc acttgtcccg aatgactgca    960

gctttttttc atgctatggc ttcactagcc ttagtttaat aaactgaatg tttggattcc   1020

tcagttattg tttacttttc atcatggaag cctgtcactg tatgtaggac ataatagaac   1080

ttgatcactt gaagctcaga cctattggtc ttgatcaaat caaactaaga agaccttaga   1140

aataagctac cattttgcca cagagcagct tataggtaat acactcttct ctcagtgcag   1200

tgtacatttc cacaaatcta agaattgccc tataaacata gcaggatttt gagagcttga   1260

aaattttcca ttattctgga catgaatttc taaaatgcct taataggttt atgtagttga   1320

gtaaattttg ttttttaatt tttgtaagca tcaaagttga ttagagaggg gggcactttt   1380

tctggagaat tctcttagta aacacaaaag attgttacgg tttcattagt agtatggttg   1440

tggggccata agttaaacag tgctgcctgg taggctggga actgaagaga cttgtggtat   1500

tccatctcgg gtgcctctgt tggcaatgat caggcagccc aaaagattta aatgatctat   1560

aataatttcc aagcggtaga ttatgtggca ttttattgct caggcaataa ttggtttaat   1620

gctggtagtg tcaaattttg aagtgttaat tttgtcttag aaccttccag taagtgaaat   1680

acaacctagt tttatcacca tatccaccag caggcatgga taattatttt aacaatgcta   1740

atatttgagt tttgcagtat attatagaat atagtccagt taaatctttg gtttcagtat   1800

gtctgaagag tacagtgaga ggttaatttc tgctcaagtg gtaccactta aaggcatgta   1860

ttcttttagt atgtaaaatg aaatagtacc ttgagtttaa atagaatgca tttaggcatt   1920

gtagagatct gaaatagttt tcttccacta cattgttgaa atcaatgaag caattagttt   1980

ctcattcaga aatgtgcaca ctaatattta gttttgcttt ctcgtggata atattaagca   2040

cttactctgc agtttcctgg aagttgtgtc aactgcagtg atactattca ggatggtggg   2100

aaatccccaa aaatatgtat gtgtgggctt gcttagatta ctatatttca tagttaatct   2160

tttgtctctt gcggtgctca tgatgtgtgg ggcacacgga aggcattgct gtagtcagtc   2220

attttggttt tcttctatag ccattttatt attttagtgt attagttatg aagataatat   2280

tatctatttg taaattgcta ctttgtattt tatgcatgct ctgtaatttg attttttttt   2340

agttattgat ttggattata ttcacattct aataaacagt tataggggga tta          2393


<210>  1758
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  1758

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  1759
<211>  5702
<212>  DNA
<213>  Homosapiens

<400>  1759
gcccgctgcc cgccgcccgg ctcccggctg ctcgcggccc cctgctcctg cctggcgctc     60

tggccaggct cgggctccgg aggacaggac cgcgcgactg gccggccgat ccctgggccg    120

gccgcgggag cagctatgct gtgactgtcc aggaatcgta tgcacacccc ttcgatcaga    180

tctattacac acgatgcaca gacatcctca actggttcaa gtgcaccagg caccgccctg    240

tgtacggagg agtgtgtgca cggccgctgc gtttccccgg acacctgcca ctgcgagcct    300

ggctggggag ggcccgactg ctccagcggc tgcgacagcg accactgggg gccccactgc    360

agcaaccggt gccagtgcca gaacggcgcc ctgtgtaacc ccatcacagg cgcctgcgtg    420

tgcgccgccg gcttccgtgg atggcgctgc gaggagctct gcgcgcctgg cacccacggc    480

aagggatgcc agctgccgtg ccagtgccga cacggtgcca gctgcgaccc ccgcgccggc    540

gagtgcctct gcgcacctgg ctacaccggc gtctactgcg aggagctgtg ccctcctggg    600

agccatggag ctcactgtga gctgcgctgc ccctgtcaga atgggggcac ctgccaccac    660

atcactggcg agtgtgcctg ccccccaggc tggacgggag cagtgtgtgc ccagccctgc    720

ccaccaggga catttggcca gaactgcagc caggattgtc cttgccacca tggagggcag    780

tgtgaccacg tgactggaca gtgccactgt acagctggat acatggggga caggtgccaa    840

gaggagtgcc ccttcgggtc cttcggcttc cagtgctcac agcgctgtga ctgccacaat    900

ggggggcagt gttcacccac cacgggtgcc tgcgagtgtg agcctggcta caagggccca    960

cgctgccagg agcgactgtg cccggagggc ctgcatggcc caggctgcac cctgccctgc   1020

ccctgtgacg ctgacaacac catcagctgc cacccagtaa ctggagcttg tacctgccag   1080

ccaggctggt ctggtcacca ctgcaatgaa tcctgccctg ttggctacta tggcgatggc   1140

tgccagctgc cttgcacctg tcagaatggc gccgactgcc acagcatcac tgggggctgc   1200

acttgtgctc cgggcttcat gggagaggtc tgtgccgttt cctgtgcagc agggacctat   1260

ggccccaact gctcgtccat ctgtagctgt aacaatggtg gcacctgctc cccagtagat   1320

ggctcctgta cctgcaagga agggtggcag ggcctggact gcaccctgcc atgtcccagt   1380

gggacgtggg gcctgaactg caacgagagc tgcacctgtg ccaatggggc agcctgcagc   1440

cccatagacg gctcctgctc ctgcactcct ggctggctgg gagacacctg tgagctgcct   1500

tgcccggatg gcacatttgg gctgaactgc agtgaacact gtgactgcag ccatgctgat   1560

ggatgtgacc ccgtcacagg ccactgctgc tgcctggccg gatggacagg catccgctgt   1620

gacagcacgt gtccacctgg ccgctggggc cccaactgct ctgtctcctg cagctgtgag   1680

aatggaggct cctgctcccc agaggatggg agctgcgagt gtgcccctgg cttccgagga   1740

cccttatgcc agagaatctg cccccctggg ttctatggcc acggctgcgc ccagccatgc   1800

cccctctgcg tgcacagcag caggccctgc caccacatca gcggcatctg tgagtgcctc   1860

ccaggattct ctggagctct ctgcaaccaa gtgtgtgctg gaggatactt tgggcaggac   1920

tgtgcccagc tctgctcctg tgccaacaac gggacctgca gccctatcga tggctcctgc   1980

cagtgctttc ctggatggat tggcaaggac tgctcacagg cttgcccacc cgggttctgg   2040

ggccccgcct gcttccacgc atgcagctgc cacaacgggg cgagctgcag cgccgaggac   2100

ggggcctgcc actgcacccc tggctggact ggactcttct gcacacagcg ctgcccagca   2160

gcattttttg ggaaggactg tgggcgcgta tgccagtgtc agaatggcgc cagctgtgac   2220

cacatcagtg gcaagtgcac ctgccgcaca ggcttcaccg ggcaacactg tgagcagaga   2280

tgtgccccag gaacctttgg ctatgggtgt cagcagctat gtgagtgcat gaacaactcc   2340

acctgtgacc atgtcaccgg cacctgttac tgcagccctg gcttcaaagg aatcaggtgt   2400

gaccaagctg ccctcatgat ggaggagctg aatccctaca ccaagatcag cccagcactg   2460

ggtgcagagc ggcactcggt gggtgctgtc acaggcatca tgctcctgtt attcttcatt   2520

gtggtgctgc tgggcctatt tgcctggcat cggcggcggc agaaagagaa gggccgagac   2580

ctggctcccc gtgtctccta cacacctgcc atgaggatga ccagcaccga ctactccctc   2640

tcaggtgctt gtggaatgga tagacgtcag aacacataca ttatggacaa aggcttcaaa   2700

gattacatga aagaatccgt gtgcagttct agtacttgtt ccttgaatag cagtgaaaac   2760

ccttacgcca caattaagga cccacccatc ctcacctgca agcttccaga aagcagctat   2820

gtagaaatga agtcgcctgt gcacatgggg tctccgtaca cagatgtgcc atccttgtcg   2880

acatctaata aaaatatata tgaagttgag cccacagtca gtgtggtcca agaaggttgc   2940

ggtcataact ccagctatat ccagaatgca tacgacctac ctaggaacag ccatattcct   3000

ggtcattatg acctcctccc agtaagacag agccctgcca atgggccgtc ccaggacaag   3060

caatcttaag agggataagc ttctctcttg cagtgtgctc tactgaatat tctgactctg   3120

aaagaagaca gtcccttgac ttgaagtaat ggtacagact ggctccagct gcatgttagt   3180

tattacgttc acctggaact aaagaagagc gtccaggtgg gactgggata attgttcaag   3240

gaattgtgtt ctcaaaggca aatcctatca cccactcagc cccaaatgcc ctggattata   3300

tgatttttaa aacattttaa gatacagcta ctcatcaaca tcagctaaat atagctgata   3360

tatatatata tatttatctg aaacgtgata ttttaaaaac atgtaggttt aacaaacctt   3420

cctaggacaa aaaggagact ggggagggaa gaggattact ttaaagcacc tgaaacgtat   3480

atgtactttt ggttgctgtt accatcaaca tctgttttat taccgaagac aattagtaca   3540

cagacatgaa ctgttcttaa acagaacagt cttaaaatgt ctgtacatat ctgtctggtc   3600

catcaaatta caacagccaa gattacagaa tctatatagt ctaatgctga caacttctat   3660

tttaaaaaac aagactttac tttcttctgc cccctaagtg ataggtttaa acacacagag   3720

acacacacac acgtttccaa agtgcagcag tgtctctttc agtctacaat aagattccta   3780

gggcagcttt atcaaatttt gccaattcaa agttcaagga cattacaagt tagtcctggc   3840

tttgtcatat ctacttagtc catccgacac ctgaatcatt ccatgtaaaa cagagctcta   3900

agatgatcct ttaagcaagc agtcatagac tggtcgggat taagtaaaag acggctagtt   3960

ggcctcctca ttttatttgg tcagcatccc ttgactcaag agtacttgct ttcaagttct   4020

tcataaatct tgagattgac gtagtatgaa acctaaaagt atacaggaaa ttggacaaat   4080

gtggatacag caagtttaca ctgcttaaag tacattatgc tttttaatgg aactaaatga   4140

tcaaaaaaag aatggactgt aaccagttgc tgtaacatga tgtaaaaacg ttactgtaaa   4200

cagcatgagg atatgaagtc cttccacctt ctatcttaaa actactactt actgagctag   4260

cccaatatgc attacaatga gctaatgctc cagatcccag tattcagatg tgtctatacc   4320

ttccactatg aacacagata aactgaggct cagataagtc caaatgaaat gaaatcaact   4380

cccaagccct aaagagaacc ttctcacaag aattaaaaac aaaaagggca aacctaggaa   4440

gctaacggct actcctgtac cactctattc actggtacag tccagccagt aaaaaacact   4500

tccaaaaaga tacacagaag aggaactaaa tgactgcgaa gctggaatac tgctacagga   4560

agtatgagag ttctgaaacc cttgatagaa actggaagcc tgccatggaa cacaatactt   4620

tgggcaataa tcagaaaaag caaaaaaata aataaatgag tacatctccc cttcccacat   4680

cactcaaggc ataagcagat tttactgtta gaggaaaata tgtaatactt acatgaatgt   4740

tgcatgtgtg catgggagca actgagtagc aatagtaaat ttactttcca aaaaagcctt   4800

attaaaatat aaatattaga aaattacttt ggagacccaa gtaaatattt ctcatacata   4860

tgtagaaaga aatataggta agcagcttac ctcagtattt cagggcagca agtgtttgtg   4920

aagcaaggat gagcagcatg aagatgtcag atcagcaagg agaaacttca actcaatccc   4980

aggttttctc ttcttccctt atcctgcatg tacaataact gctgcctggc aaactgcaaa   5040

caagcagcat cactcaagtt tgaagtttcg ccgcttttgt caactatcct ctgggcaaag   5100

gtattcagca agaggtggaa tggctagaca ctgaatcaag agatttcagt gttactctgg   5160

tcaagttagt cgccctctct gggctccctt tttttctatg cataaaaagg ggagaagcag   5220

agagtgggaa gacagctcta ctaacccttc agctctagca gtccatgact ttttaaggaa   5280

atgtaataca agtcaaacca ggcaatacag aggagaaggg aaaggcagag ggtgtgatta   5340

tggtgacaat agctgccttc ccctatcgaa cagttatcag taaaagacat ttcaatctta   5400

caaagcaact gttagaaact tctgtctaac accatcacaa ataggttcat ggtcagccta   5460

aacatgtata ctgtgcattt tatgggtgac tttgaaagat ctgttcaatt atttttcaga   5520

aactaaattt tcaaaaaatt aatatgtgta caattaaaat gaatgaaaga aaaaccatta   5580

ttgtacagag gtattaatga gactatgaaa cggcaatact tttttaaatc acagatttgt   5640

aatatatgtt cactgtgcag agggattgta ccttgtacaa aataaaacaa atttctcaaa   5700

ct                                                                  5702


<210>  1760
<211>  969
<212>  PRT
<213>  Homosapiens

<400>  1760

Met His Thr Pro Ser Ile Arg Ser Ile Thr His Asp Ala Gln Thr Ser 
1               5                   10                  15      


Ser Thr Gly Ser Ser Ala Pro Gly Thr Ala Leu Cys Thr Glu Glu Cys 
            20                  25                  30          


Val His Gly Arg Cys Val Ser Pro Asp Thr Cys His Cys Glu Pro Gly 
        35                  40                  45              


Trp Gly Gly Pro Asp Cys Ser Ser Gly Cys Asp Ser Asp His Trp Gly 
    50                  55                  60                  


Pro His Cys Ser Asn Arg Cys Gln Cys Gln Asn Gly Ala Leu Cys Asn 
65                  70                  75                  80  


Pro Ile Thr Gly Ala Cys Val Cys Ala Ala Gly Phe Arg Gly Trp Arg 
                85                  90                  95      


Cys Glu Glu Leu Cys Ala Pro Gly Thr His Gly Lys Gly Cys Gln Leu 
            100                 105                 110         


Pro Cys Gln Cys Arg His Gly Ala Ser Cys Asp Pro Arg Ala Gly Glu 
        115                 120                 125             


Cys Leu Cys Ala Pro Gly Tyr Thr Gly Val Tyr Cys Glu Glu Leu Cys 
    130                 135                 140                 


Pro Pro Gly Ser His Gly Ala His Cys Glu Leu Arg Cys Pro Cys Gln 
145                 150                 155                 160 


Asn Gly Gly Thr Cys His His Ile Thr Gly Glu Cys Ala Cys Pro Pro 
                165                 170                 175     


Gly Trp Thr Gly Ala Val Cys Ala Gln Pro Cys Pro Pro Gly Thr Phe 
            180                 185                 190         


Gly Gln Asn Cys Ser Gln Asp Cys Pro Cys His His Gly Gly Gln Cys 
        195                 200                 205             


Asp His Val Thr Gly Gln Cys His Cys Thr Ala Gly Tyr Met Gly Asp 
    210                 215                 220                 


Arg Cys Gln Glu Glu Cys Pro Phe Gly Ser Phe Gly Phe Gln Cys Ser 
225                 230                 235                 240 


Gln Arg Cys Asp Cys His Asn Gly Gly Gln Cys Ser Pro Thr Thr Gly 
                245                 250                 255     


Ala Cys Glu Cys Glu Pro Gly Tyr Lys Gly Pro Arg Cys Gln Glu Arg 
            260                 265                 270         


Leu Cys Pro Glu Gly Leu His Gly Pro Gly Cys Thr Leu Pro Cys Pro 
        275                 280                 285             


Cys Asp Ala Asp Asn Thr Ile Ser Cys His Pro Val Thr Gly Ala Cys 
    290                 295                 300                 


Thr Cys Gln Pro Gly Trp Ser Gly His His Cys Asn Glu Ser Cys Pro 
305                 310                 315                 320 


Val Gly Tyr Tyr Gly Asp Gly Cys Gln Leu Pro Cys Thr Cys Gln Asn 
                325                 330                 335     


Gly Ala Asp Cys His Ser Ile Thr Gly Gly Cys Thr Cys Ala Pro Gly 
            340                 345                 350         


Phe Met Gly Glu Val Cys Ala Val Ser Cys Ala Ala Gly Thr Tyr Gly 
        355                 360                 365             


Pro Asn Cys Ser Ser Ile Cys Ser Cys Asn Asn Gly Gly Thr Cys Ser 
    370                 375                 380                 


Pro Val Asp Gly Ser Cys Thr Cys Lys Glu Gly Trp Gln Gly Leu Asp 
385                 390                 395                 400 


Cys Thr Leu Pro Cys Pro Ser Gly Thr Trp Gly Leu Asn Cys Asn Glu 
                405                 410                 415     


Ser Cys Thr Cys Ala Asn Gly Ala Ala Cys Ser Pro Ile Asp Gly Ser 
            420                 425                 430         


Cys Ser Cys Thr Pro Gly Trp Leu Gly Asp Thr Cys Glu Leu Pro Cys 
        435                 440                 445             


Pro Asp Gly Thr Phe Gly Leu Asn Cys Ser Glu His Cys Asp Cys Ser 
    450                 455                 460                 


His Ala Asp Gly Cys Asp Pro Val Thr Gly His Cys Cys Cys Leu Ala 
465                 470                 475                 480 


Gly Trp Thr Gly Ile Arg Cys Asp Ser Thr Cys Pro Pro Gly Arg Trp 
                485                 490                 495     


Gly Pro Asn Cys Ser Val Ser Cys Ser Cys Glu Asn Gly Gly Ser Cys 
            500                 505                 510         


Ser Pro Glu Asp Gly Ser Cys Glu Cys Ala Pro Gly Phe Arg Gly Pro 
        515                 520                 525             


Leu Cys Gln Arg Ile Cys Pro Pro Gly Phe Tyr Gly His Gly Cys Ala 
    530                 535                 540                 


Gln Pro Cys Pro Leu Cys Val His Ser Ser Arg Pro Cys His His Ile 
545                 550                 555                 560 


Ser Gly Ile Cys Glu Cys Leu Pro Gly Phe Ser Gly Ala Leu Cys Asn 
                565                 570                 575     


Gln Val Cys Ala Gly Gly Tyr Phe Gly Gln Asp Cys Ala Gln Leu Cys 
            580                 585                 590         


Ser Cys Ala Asn Asn Gly Thr Cys Ser Pro Ile Asp Gly Ser Cys Gln 
        595                 600                 605             


Cys Phe Pro Gly Trp Ile Gly Lys Asp Cys Ser Gln Ala Cys Pro Pro 
    610                 615                 620                 


Gly Phe Trp Gly Pro Ala Cys Phe His Ala Cys Ser Cys His Asn Gly 
625                 630                 635                 640 


Ala Ser Cys Ser Ala Glu Asp Gly Ala Cys His Cys Thr Pro Gly Trp 
                645                 650                 655     


Thr Gly Leu Phe Cys Thr Gln Arg Cys Pro Ala Ala Phe Phe Gly Lys 
            660                 665                 670         


Asp Cys Gly Arg Val Cys Gln Cys Gln Asn Gly Ala Ser Cys Asp His 
        675                 680                 685             


Ile Ser Gly Lys Cys Thr Cys Arg Thr Gly Phe Thr Gly Gln His Cys 
    690                 695                 700                 


Glu Gln Arg Cys Ala Pro Gly Thr Phe Gly Tyr Gly Cys Gln Gln Leu 
705                 710                 715                 720 


Cys Glu Cys Met Asn Asn Ser Thr Cys Asp His Val Thr Gly Thr Cys 
                725                 730                 735     


Tyr Cys Ser Pro Gly Phe Lys Gly Ile Arg Cys Asp Gln Ala Ala Leu 
            740                 745                 750         


Met Met Glu Glu Leu Asn Pro Tyr Thr Lys Ile Ser Pro Ala Leu Gly 
        755                 760                 765             


Ala Glu Arg His Ser Val Gly Ala Val Thr Gly Ile Met Leu Leu Leu 
    770                 775                 780                 


Phe Phe Ile Val Val Leu Leu Gly Leu Phe Ala Trp His Arg Arg Arg 
785                 790                 795                 800 


Gln Lys Glu Lys Gly Arg Asp Leu Ala Pro Arg Val Ser Tyr Thr Pro 
                805                 810                 815     


Ala Met Arg Met Thr Ser Thr Asp Tyr Ser Leu Ser Gly Ala Cys Gly 
            820                 825                 830         


Met Asp Arg Arg Gln Asn Thr Tyr Ile Met Asp Lys Gly Phe Lys Asp 
        835                 840                 845             


Tyr Met Lys Glu Ser Val Cys Ser Ser Ser Thr Cys Ser Leu Asn Ser 
    850                 855                 860                 


Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp Pro Pro Ile Leu Thr Cys 
865                 870                 875                 880 


Lys Leu Pro Glu Ser Ser Tyr Val Glu Met Lys Ser Pro Val His Met 
                885                 890                 895     


Gly Ser Pro Tyr Thr Asp Val Pro Ser Leu Ser Thr Ser Asn Lys Asn 
            900                 905                 910         


Ile Tyr Glu Val Glu Pro Thr Val Ser Val Val Gln Glu Gly Cys Gly 
        915                 920                 925             


His Asn Ser Ser Tyr Ile Gln Asn Ala Tyr Asp Leu Pro Arg Asn Ser 
    930                 935                 940                 


His Ile Pro Gly His Tyr Asp Leu Leu Pro Val Arg Gln Ser Pro Ala 
945                 950                 955                 960 


Asn Gly Pro Ser Gln Asp Lys Gln Ser 
                965                 


<210>  1761
<211>  2284
<212>  DNA
<213>  Homosapiens

<400>  1761
acactggaaa gaggggcttg gagagggaga cagggccaga catgttctag cagagagatg     60

gtatattact cccttctcac gctgctaaga aggaatacct gagactgggt aatttataaa    120

gaaaagaggt ttaattgact cacagttccg catggctgtg gcgggggggc ggccacaaga    180

aacttaacaa tcatggcaga aggacctctt cacaggacag caggagagag aacgagtacc    240

agcaggggaa atgccagatg cttataaaac catcagatct tgtgagaact cactcaccat    300

cacaagaaca gtatggggga agcagccccc ttcattcaat tacctcccgc cggatccctc    360

ccacaacaca tggtgattat ggggattaca attcaagatg agatgtgggc ggggacacag    420

acaaaccaca ggagatgtgt gaagattgct tgtggcttat cagtggtccc tttctgcctt    480

aagggtgatg gaatcaaaaa gaacttctcc atccttggct ttgatatttc aggcgcacaa    540

acaaggcctc attcaccctt cccagagctg atccactggc gtgatttgct ctaatgccaa    600

catcaccacc cctccccaga ggccctgcca gcctctactc tcccaggaag tcagccccac    660

tctgctggct agtcctggct ctctactgtc tttctgggcc catcatggct ccctgaccac    720

ccaactctga aacaatctcc cggtccaggg catcccagga accaggtcat tgatggagcc    780

gctatttggc agttgcaggt ggggcaggaa tggtatgggg aagtagaggc agaatgaaat    840

ggcctggaag aagttaccct ttttggatga gttcaaaacc cctagggctg atgcacccaa    900

cccctgctct gtcattcgtg acctgctctt tctagagcaa aatatcatgg gatgggaggg    960

ccctctgaat cttttcctgt gaagttgact ttgatgatat gttggtcctt ttgtcaagcc   1020

tgagctgctg tggtctgatg ctgagtgtct cacctgtaac atctcagcac ataacactcc   1080

acagtgagag ccttccttct gcccctggga gggagagctt tacagaagta tttccaagca   1140

aatttccaga aggcctcaaa gtaagcagca gaagccgctg ctggtgtcag cagcaaatca   1200

gcactcagct tgaggcctcc cagcctgccc cgggaggggc acggctcgca gcctttgcac   1260

tctgggttct ttccagggag gatcccatgg ggcacttcca ggaaggagcc cctgctgctt   1320

tctccaaaga gctctgcttc gggtctctaa ggattggttt tatctgcaga gaagctaaag   1380

gaaggaatct actggtcccc taaggacctg atgacacatg cacagagatc ccatctctct   1440

tttcattccc tgaagtaagg gaggcaatga agccatacgt gtaccacaaa gagtgtgaga   1500

aagaaggaac tctccagccg gggtctttct ctgagtcatt tttcagtcgt agggtacaaa   1560

aagctccagg ttatattcaa ggttttattt tttccagagt atcttcgggg aaaaaaagta   1620

tatctgaaaa tcacagaaat tcttttcttt caaggtaaat tagaggattt gaaggggcag   1680

tgctggatga tctctgggtt cccctctagt ccaacaccca gactctgaga ttgcttccct   1740

gtgggagctc ggcctggcct ccttccatgg gcgtttcttc caacgtggag gtttgtcagt   1800

ggcgtgcctg atggccaggg ccagatgctg ttcttcacac cagaacgtca taatttaaaa   1860

tgtctatgct ctgaagcaag aaatcagagc ttcaaaccta aaacttgtag gatttacaaa   1920

gcagtttcat tccaccaaca tctattgagt actcattatg ggccaggtac agagatgaga   1980

agtgggtctg agaacagtcc ctgcccccaa gtagttcaca aatctcattg tgaagaggca   2040

ggcacagaaa atctatccat ctggtagcgg ccaacccaag ccaggtaggc aatactttcc   2100

ctcatagagt tagagggtag tttaaagaaa ctgccaccca gagggaacgg cggtgaggtt   2160

ttaggaatta tgattccttt cctaaatttc tttgctattt gttatgagct acacaaatgt   2220

ttatacacaa gtcttaaagt tttggctgat tagaatattt tcaataaaga gagaatttct   2280

actt                                                                2284


<210>  1762
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  1762

Met Leu Val Leu Leu Ser Ser Leu Ser Cys Cys Gly Leu Met Leu Ser 
1               5                   10                  15      


Val Ser Pro Val Thr Ser Gln His Ile Thr Leu His Ser Glu Ser Leu 
            20                  25                  30          


Pro Ser Ala Pro Gly Arg Glu Ser Phe Thr Glu Val Phe Pro Ser Lys 
        35                  40                  45              


Phe Pro Glu Gly Leu Lys Val Ser Ser Arg Ser Arg Cys Trp Cys Gln 
    50                  55                  60                  


Gln Gln Ile Ser Thr Gln Leu Glu Ala Ser Gln Pro Ala Pro Gly Gly 
65                  70                  75                  80  


Ala Arg Leu Ala Ala Phe Ala Leu Trp Val Leu Ser Arg Glu Asp Pro 
                85                  90                  95      


Met Gly His Phe Gln Glu Gly Ala Pro Ala Ala Phe Ser Lys Glu Leu 
            100                 105                 110         


Cys Phe Gly Ser Leu Arg Ile Gly Phe Ile Cys Arg Glu Ala Lys Gly 
        115                 120                 125             


Arg Asn Leu Leu Val Pro 
    130                 


<210>  1763
<211>  3262
<212>  DNA
<213>  Homosapiens

<400>  1763
gaccttccat tttggtagct tcaactttgc agctgctgtg tctcttcgtc gtctgggaag     60

aaaactttca cattaagagt tgctgatgcg gattttcttt ctttcctctc ccggcgttga    120

tgagtgcttg gctcctgaca gaagggattt ggctcccagc tttgtagttc ggaagaagtt    180

gggtctatag atttccccct aactctccat tgatgtgttg agcttcagag ggaataataa    240

ctctacgtaa agcatgctgg cgtctcaagg agttctcctg catccttatg gcgtgcctat    300

gattgtaccg gcagctcctt accttcctgg actgattcag ggtaatcagg aagcagccgc    360

tgcccctgac acaatggctc agccttacgc ttcggcccag tttgctcccc cgcagaacgg    420

tatccccgcg gaatacacgg cccctcatcc ccaccccgcg ccagagtaca caggccagac    480

cacggttccc gagcacacat taaacctgta ccctcccgcc cagacgcact ccgagcagag    540

cccggcggac acgagcgctc agaccgtctc tggcaccgcc acacagacag atgacgcagc    600

accgacggat ggccagcccc agacacaacc ttctgaaaac acggaaaaca agtctcagcc    660

caagcggctg catgtctcca atatcccctt caggttccgg gatccggacc tcagacaaat    720

gtttggtcaa tttggtaaaa tcttagatgt tgaaattatt tttaatgagc gaggctcaaa    780

gggatttggt ttcgtaactt tcgaaaatag tgccgatgcg gacagggcga gggagaaatt    840

acacggcacc gtggtagagg gccgtaaaat cgaggtaaat aatgccacag cacgtgtaat    900

gacaaataaa aagaccgtca acccttatac aaatggctgg aaattgaatc cagttgtggg    960

tgcagtctac agtcccgaat tctatgcagg cacggtcctg ttgtgccagg ccaaccagga   1020

gggatcttcc atgtacagtg cccccagttc acttgtatat acttctgcaa tgccaggctt   1080

cccgtatcca gcagccaccg ccgcggccgc ctaccgaggg gcgcacctgc gaggccgcgg   1140

tcgcaccgtg tacaacacct tcagggccgc ggcgcccccg cccccgatcc cggcctacgg   1200

cggagtagtg tatcaagagc ctgtgtatgg caataaattg ctgcagggtg gttatgctgc   1260

ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca gttacggacg   1320

agtttatgct gccgacccct accaccacgc acttgctcca gcccccacct acggcgttgg   1380

tgccatgaat gcttttgcac ctttgactga tgccaagact aggagccatg ctgatgatgt   1440

gggtctcgtt ctttcttcat tgcaggctag tatataccga gggggataca accgttttgc   1500

tccatactaa atgacaaaac cataaaaacc ttccaatgtg gggagaaagg aagctttccg   1560

aggcctgagt attgcaatac atgcagtagt acatcatttt agcaactcta aaaaaaaaaa   1620

aaatacaaat aaaaaggaaa aaaaatgaca ttttttatct tatacctcag atattttgtt   1680

ctgtgtattt taatattgtg ggtctttaat ttctgaaggt tccgtagttt ggttgctggc   1740

tgtaggagtt tttgtggttg atctagacag atgctagata atgaataaaa actggtttag   1800

ggccatatcc agagtgctat attatgtaaa tgaattatat atgctgaata ttaagctact   1860

ggggttatca gctgtttggg aagagtgtaa gtgactacag tagtcatttt tttctgcacc   1920

tgcattattt tattttgtga aaggggaggt tgggaggggc ttaggggatt ggaactgggg   1980

tttggctgaa agaaaaaaaa aaaaatgtaa ctgatgaatc taaacgaccc actgcaccaa   2040

caatcattta tcaatggttc taagttactc attgccagtt caagccaaag gtcatgttgt   2100

taagggggtg cttctagtag cacttgtgca tctgagttga atgaagctgt gcaaacccac   2160

cctttaaacc attccacccg gcagtattca gcttcttaac cagtcgctat ttaggaaaaa   2220

aaacccacta gttaggccat caacaagcat tctttttata tttcttccag tataataaat   2280

tattgatatc actgctgact tttatattat gggagggaaa aaataacatt aataaaaagg   2340

tgataaaaaa gcactgtttc tatttttttc tttttttcca aaaaaagaaa gtaataaaaa   2400

cttaaattct ttgtaccagt taaaaaaaat gtataaaatt tacatctgtg cagtggagtt   2460

gttaagttct agaaacagtc tatgaagctt tagttttagc ctagtagaac aactgttaga   2520

gacagacgta taatttttat ggaattacat gataatcata ttcggattta tagaagcatt   2580

ttacaagtat tgcaatcatt gagtagagat aatcatggta ttttcatcag cttggtactt   2640

tttgaaacgt gactgcgttg tgtgaacaat ctgcaatttt tcagtccgtg agatcctgcc   2700

cttccacctc tttcccatac ccccaaggat tatctcaaaa tgatctcttt agttctgtct   2760

ccaaggccca ggacacttgt cagaaggatg caaaaaaaga aaaaagtaca tccaccctct   2820

taatcccaaa agaacaaagt ctccccacct ttctcggatg cagggccaga gtgacacagc   2880

cgaaaaattg cagtttgtct gtacttctgt ttgaactttc cacgttgtcc tgtttacaag   2940

ttaacttaag ttggggtatc cgtcacgggt cttcctgttt tgtatttaaa taaaaacaac   3000

agcagcaggc tgtccctgag tagttttgct gccataggtt aagtcctcat gtgtacagtg   3060

caggccctgt ggcccgcact tcagtaagtt atcaactctc accgctgtga acctgccaat   3120

ccgctgtaac aactctgctt taaaacaaaa ccaaacaaaa ctttaaaaaa aaatgtgtga   3180

tccagctttc tcttgccatc ctatgtgcat gccgtaagat cagttggata ttaaaccatc   3240

aataaagttt cacaagattt ga                                            3262


<210>  1764
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  1764

Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
        355                 360                 365             


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu 
    370                 375                 380                 


Thr Asp Ala Lys Thr Arg Ser His Ala Asp Asp Val Gly Leu Val Leu 
385                 390                 395                 400 


Ser Ser Leu Gln Ala Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala 
                405                 410                 415     


Pro Tyr 
        


<210>  1765
<211>  3184
<212>  DNA
<213>  Homosapiens

<400>  1765
gaccttccat tttggtagct tcaactttgc agctgctgtg tctcttcgtc gtctgggaag     60

aaaactttca cattaagagt tgctgatgcg gattttcttt ctttcctctc ccggcgttga    120

tgagtgcttg gctcctgaca gaagggattt ggctcccagc tttgtagttc ggaagaagtt    180

gggtctatag atttccccct aactctccat tgatgtgttg agcttcagag ggaataataa    240

ctctacgtaa agcatgctgg cgtctcaagg agttctcctg catccttatg gcgtgcctat    300

gattgtaccg gcagctcctt accttcctgg actgattcag ggtaatcagg aagcagccgc    360

tgcccctgac acaatggctc agccttacgc ttcggcccag tttgctcccc cgcagaacgg    420

tatccccgcg gaatacacgg cccctcatcc ccaccccgcg ccagagtaca caggccagac    480

cacggttccc gagcacacat taaacctgta ccctcccgcc cagacgcact ccgagcagag    540

cccggcggac acgagcgctc agaccgtctc tggcaccgcc acacagacag atgacgcagc    600

accgacggat ggccagcccc agacacaacc ttctgaaaac acggaaaaca agtctcagcc    660

caagcggctg catgtctcca atatcccctt caggttccgg gatccggacc tcagacaaat    720

gtttggtcaa tttggtaaaa tcttagatgt tgaaattatt tttaatgagc gaggctcaaa    780

gggatttggt ttcgtaactt tcgaaaatag tgccgatgcg gacagggcga gggagaaatt    840

acacggcacc gtggtagagg gccgtaaaat cgaggtaaat aatgccacag cacgtgtaat    900

gacaaataaa aagaccgtca acccttatac aaatggctgg aaattgaatc cagttgtggg    960

tgcagtctac agtcccgaat tctatgcagg cacggtcctg ttgtgccagg ccaaccagga   1020

gggatcttcc atgtacagtg cccccagttc acttgtatat acttctgcaa tgccaggctt   1080

cccgtatcca gcagccaccg ccgcggccgc ctaccgaggg gcgcacctgc gaggccgcgg   1140

tcgcaccgtg tacaacacct tcagggccgc ggcgcccccg cccccgatcc cggcctacgg   1200

cggagtagtg tatcaagagc ctgtgtatgg caataaattg ctgcagggtg gttatgctgc   1260

ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca gttacggacg   1320

agtttatgct gccgacccct accaccacgc acttgctcca gcccccacct acggcgttgg   1380

tgccatggct agtatatacc gagggggata caaccgtttt gctccatact aaatgacaaa   1440

accataaaaa ccttccaatg tggggagaaa ggaagctttc cgaggcctga gtattgcaat   1500

acatgcagta gtacatcatt ttagcaactc taaaaaaaaa aaaaatacaa ataaaaagga   1560

aaaaaaatga cattttttat cttatacctc agatattttg ttctgtgtat tttaatattg   1620

tgggtcttta atttctgaag gttccgtagt ttggttgctg gctgtaggag tttttgtggt   1680

tgatctagac agatgctaga taatgaataa aaactggttt agggccatat ccagagtgct   1740

atattatgta aatgaattat atatgctgaa tattaagcta ctggggttat cagctgtttg   1800

ggaagagtgt aagtgactac agtagtcatt tttttctgca cctgcattat tttattttgt   1860

gaaaggggag gttgggaggg gcttagggga ttggaactgg ggtttggctg aaagaaaaaa   1920

aaaaaaatgt aactgatgaa tctaaacgac ccactgcacc aacaatcatt tatcaatggt   1980

tctaagttac tcattgccag ttcaagccaa aggtcatgtt gttaaggggg tgcttctagt   2040

agcacttgtg catctgagtt gaatgaagct gtgcaaaccc accctttaaa ccattccacc   2100

cggcagtatt cagcttctta accagtcgct atttaggaaa aaaaacccac tagttaggcc   2160

atcaacaagc attcttttta tatttcttcc agtataataa attattgata tcactgctga   2220

cttttatatt atgggaggga aaaaataaca ttaataaaaa ggtgataaaa aagcactgtt   2280

tctatttttt tctttttttc caaaaaaaga aagtaataaa aacttaaatt ctttgtacca   2340

gttaaaaaaa atgtataaaa tttacatctg tgcagtggag ttgttaagtt ctagaaacag   2400

tctatgaagc tttagtttta gcctagtaga acaactgtta gagacagacg tataattttt   2460

atggaattac atgataatca tattcggatt tatagaagca ttttacaagt attgcaatca   2520

ttgagtagag ataatcatgg tattttcatc agcttggtac tttttgaaac gtgactgcgt   2580

tgtgtgaaca atctgcaatt tttcagtccg tgagatcctg cccttccacc tctttcccat   2640

acccccaagg attatctcaa aatgatctct ttagttctgt ctccaaggcc caggacactt   2700

gtcagaagga tgcaaaaaaa gaaaaaagta catccaccct cttaatccca aaagaacaaa   2760

gtctccccac ctttctcgga tgcagggcca gagtgacaca gccgaaaaat tgcagtttgt   2820

ctgtacttct gtttgaactt tccacgttgt cctgtttaca agttaactta agttggggta   2880

tccgtcacgg gtcttcctgt tttgtattta aataaaaaca acagcagcag gctgtccctg   2940

agtagttttg ctgccatagg ttaagtcctc atgtgtacag tgcaggccct gtggcccgca   3000

cttcagtaag ttatcaactc tcaccgctgt gaacctgcca atccgctgta acaactctgc   3060

tttaaaacaa aaccaaacaa aactttaaaa aaaaatgtgt gatccagctt tctcttgcca   3120

tcctatgtgc atgccgtaag atcagttgga tattaaacca tcaataaagt ttcacaagat   3180

ttga                                                                3184


<210>  1766
<211>  392
<212>  PRT
<213>  Homosapiens

<400>  1766

Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
        355                 360                 365             


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Ala Ser Ile Tyr Arg Gly 
    370                 375                 380                 


Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390         


<210>  1767
<211>  3315
<212>  DNA
<213>  Homosapiens

<400>  1767
gaccttccat tttggtagct tcaactttgc agctgctgtg tctcttcgtc gtctgggaag     60

aaaactttca cattaagagt tgctgatgcg gattttcttt ctttcctctc ccggcgttga    120

tgagtgcttg gctcctgaca gaagggattt ggctcccagc tttgtagttc ggaagaagtt    180

gggtctatag atttccccct aactctccat tgatgtgttg agcttcagag ggaataataa    240

ctctacgtaa agcatgctgg cgtctcaagg agttctcctg catccttatg gcgtgcctat    300

gattgtaccg gcagctcctt accttcctgg actgattcag ggtaatcagg aagcagccgc    360

tgcccctgac acaatggctc agccttacgc ttcggcccag tttgctcccc cgcagaacgg    420

tatccccgcg gaatacacgg cccctcatcc ccaccccgcg ccagagtaca caggccagac    480

cacggttccc gagcacacat taaacctgta ccctcccgcc cagacgcact ccgagcagag    540

cccggcggac acgagcgctc agaccgtctc tggcaccgcc acacagacag atgacgcagc    600

accgacggat ggccagcccc agacacaacc ttctgaaaac acggaaaaca agtctcagcc    660

caagcggctg catgtctcca atatcccctt caggttccgg gatccggacc tcagacaaat    720

gtttggtcaa tttggtaaaa tcttagatgt tgaaattatt tttaatgagc gaggctcaaa    780

gggatttggt ttcgtaactt tcgaaaatag tgccgatgcg gacagggcga gggagaaatt    840

acacggcacc gtggtagagg gccgtaaaat cgaggtaaat aatgccacag cacgtgtaat    900

gacaaataaa aagaccgtca acccttatac aaatggctgg aaattgaatc cagttgtggg    960

tgcagtctac agtcccgaat tctatgcagg cacggtcctg ttgtgccagg ccaaccagga   1020

gggatcttcc atgtacagtg cccccagttc acttgtatat acttctgcaa tgccaggctt   1080

cccgtatcca gcagccaccg ccgcggccgc ctaccgaggg gcgcacctgc gaggccgcgg   1140

tcgcaccgtg tacaacacct tcagggccgc ggcgcccccg cccccgatcc cggcctacgg   1200

cggagtagtg tatcaagagc ctgtgtatgg caataaattg ctgcagggtg gttatgctgc   1260

ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca gaaatcagtt   1320

cgtcttcgtt gcagcagatg aaatttcttg taacacctct gcagttacgg acgagtttat   1380

gctgccgacc cctaccacca cgcacttgct ccagccccca cctacggcgt tggtgccatg   1440

aatgcttttg cacctttgac tgatgccaag actaggagcc atgctgatga tgtgggtctc   1500

gttctttctt cattgcaggc tagtatatac cgagggggat acaaccgttt tgctccatac   1560

taaatgacaa aaccataaaa accttccaat gtggggagaa aggaagcttt ccgaggcctg   1620

agtattgcaa tacatgcagt agtacatcat tttagcaact ctaaaaaaaa aaaaaataca   1680

aataaaaagg aaaaaaaatg acatttttta tcttatacct cagatatttt gttctgtgta   1740

ttttaatatt gtgggtcttt aatttctgaa ggttccgtag tttggttgct ggctgtagga   1800

gtttttgtgg ttgatctaga cagatgctag ataatgaata aaaactggtt tagggccata   1860

tccagagtgc tatattatgt aaatgaatta tatatgctga atattaagct actggggtta   1920

tcagctgttt gggaagagtg taagtgacta cagtagtcat ttttttctgc acctgcatta   1980

ttttattttg tgaaagggga ggttgggagg ggcttagggg attggaactg gggtttggct   2040

gaaagaaaaa aaaaaaaatg taactgatga atctaaacga cccactgcac caacaatcat   2100

ttatcaatgg ttctaagtta ctcattgcca gttcaagcca aaggtcatgt tgttaagggg   2160

gtgcttctag tagcacttgt gcatctgagt tgaatgaagc tgtgcaaacc caccctttaa   2220

accattccac ccggcagtat tcagcttctt aaccagtcgc tatttaggaa aaaaaaccca   2280

ctagttaggc catcaacaag cattcttttt atatttcttc cagtataata aattattgat   2340

atcactgctg acttttatat tatgggaggg aaaaaataac attaataaaa aggtgataaa   2400

aaagcactgt ttctattttt ttcttttttt ccaaaaaaag aaagtaataa aaacttaaat   2460

tctttgtacc agttaaaaaa aatgtataaa atttacatct gtgcagtgga gttgttaagt   2520

tctagaaaca gtctatgaag ctttagtttt agcctagtag aacaactgtt agagacagac   2580

gtataatttt tatggaatta catgataatc atattcggat ttatagaagc attttacaag   2640

tattgcaatc attgagtaga gataatcatg gtattttcat cagcttggta ctttttgaaa   2700

cgtgactgcg ttgtgtgaac aatctgcaat ttttcagtcc gtgagatcct gcccttccac   2760

ctctttccca tacccccaag gattatctca aaatgatctc tttagttctg tctccaaggc   2820

ccaggacact tgtcagaagg atgcaaaaaa agaaaaaagt acatccaccc tcttaatccc   2880

aaaagaacaa agtctcccca cctttctcgg atgcagggcc agagtgacac agccgaaaaa   2940

ttgcagtttg tctgtacttc tgtttgaact ttccacgttg tcctgtttac aagttaactt   3000

aagttggggt atccgtcacg ggtcttcctg ttttgtattt aaataaaaac aacagcagca   3060

ggctgtccct gagtagtttt gctgccatag gttaagtcct catgtgtaca gtgcaggccc   3120

tgtggcccgc acttcagtaa gttatcaact ctcaccgctg tgaacctgcc aatccgctgt   3180

aacaactctg ctttaaaaca aaaccaaaca aaactttaaa aaaaaatgtg tgatccagct   3240

ttctcttgcc atcctatgtg catgccgtaa gatcagttgg atattaaacc atcaataaag   3300

tttcacaaga tttga                                                    3315


<210>  1768
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  1768

Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Arg Asn Gln Phe Val Phe Val Ala Ala Asp Glu Ile Ser Cys Asn Thr 
        355                 360                 365             


Ser Ala Val Thr Asp Glu Phe Met Leu Pro Thr Pro Thr Thr Thr His 
    370                 375                 380                 


Leu Leu Gln Pro Pro Pro Thr Ala Leu Val Pro 
385                 390                 395 


<210>  1769
<211>  2279
<212>  DNA
<213>  Homosapiens

<400>  1769
tccggctctc ctttgtttat tttctaatct atatttttac tggaagattt cctctttatt     60

ctctcccgcc ctcctacaag cgctcttgct ggccgtctgg gtgcacacac cgctccctcg    120

atcaccccag cccccttcct ggtctcccga gcgcggggtt tgaaggtcac ctcctttcca    180

gtccccgtgc gagccgcgct gccgccgcct cctccagcca gagtcggtgg gactggctgc    240

gctgccctga agtggttctc caagcagcgc ggagggtggc ggacggcgga cggagcccag    300

gggccgcgtc gggtggggaa acccgaactc gcggagggga atccctcccc cttcgcccca    360

gccccccagc agcacccgcg gtggggcggg ggcgctctgc cagccccggg aacagcagag    420

gcggcggcac tggctggacc cacgcgcgcg cctccggggc tgaagaagga aggagtgagc    480

cgagccgagc accccacatc tggaggggac agccagccgt gggccccgcc ccggcgtccg    540

gagcaggaga attccgagct tcttgcccag gcagagagag caggagcgga ccgcgcgccc    600

gggattgaga gtccttgcgc tccagacccc cacccagtgg ccgccaggtc ccgcctgtcc    660

ggaccctcgc cgcgcccagg caggcgcgcc agggcggggc tgacctgccc gcgaagttgc    720

ggacagtgcg tgagaaacca gcaccccctt ccgccgcctc cagcttatgg tgagtgtggc    780

tgggggtgca gagagcgcac gggaattcgg gggtctgggg ccgagaacgt gaccgcagcc    840

gggctcgccg ggagttctag gaaactggtc aaagaactca tgcaagtgga acttacagct    900

tccttgatcg gactcagcat tcagatatca aagcagactg caatacctgc gtggaaatag    960

aagacagaaa ggtttcaaga caacagatga attgtgaaag agagcagcta aggggtaatc   1020

aggaagcagc cgctgcccct gacacaatgg ctcagcctta cgcttcggcc cagtttgctc   1080

ccccgcagaa cggtatcccc gcggaataca cggcccctca tccccacccc gcgccagagt   1140

acacaggcca gaccacggtt cccgagcaca cattaaacct gtaccctccc gcccagacgc   1200

actccgagca gagcccggcg gacacgagcg ctcagaccgt ctctggcacc gccacacaga   1260

cagatgacgc agcaccgacg gatggccagc cccagacaca accttctgaa aacacggaaa   1320

acaagtctca gcccaagcgg ctgcatgtct ccaatatccc cttcaggttc cgggatccgg   1380

acctcagaca aatgtttggt caatttggta aaatcttaga tgttgaaatt atttttaatg   1440

agcgaggctc aaagggattt ggtttcgtaa ctttcgaaaa tagtgccgat gcggacaggg   1500

cgagggagaa attacacggc accgtggtag agggccgtaa aatcgaggta aataatgcca   1560

cagcacgtgt aatgacaaat aaaaagaccg tcaaccctta tacaaatggc tggaaattga   1620

atccagttgt gggtgcagtc tacagtcccg aattctatgc aggcacggtc ctgttgtgcc   1680

aggccaacca ggagggatct tccatgtaca gtgcccccag ttcacttgta tatacttctg   1740

caatgccagg cttcccgtat ccagcagcca ccgccgcggc cgcctaccga ggggcgcacc   1800

tgcgaggccg cggtcgcacc gtgtacaaca ccttcagggc cgcggcgccc ccgcccccga   1860

tcccggccta cggcggtgtt gtttaccagg atggatttta tggtgcagac atttatggtg   1920

gttatgctgc ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca   1980

gttacggacg agtttatgct gccgacccct accaccacgc acttgctcca gcccccacct   2040

acggcgttgg tgccatgaat gcttttgcac ctttgactga tgccaagact aggagccatg   2100

ctgatgatgt gggtctcgtt ctttcttcat tgcaggctag tatataccga gggggataca   2160

accgttttgc tccatactaa atgacaaaac cataaaaacc ttccaatgtg gggagaaagg   2220

aagctttccg aggcctgagt attgcaatac atgcagtagt acatcatttt agcaactct    2279


<210>  1770
<211>  397
<212>  PRT
<213>  Homosapiens

<400>  1770

Met Asn Cys Glu Arg Glu Gln Leu Arg Gly Asn Gln Glu Ala Ala Ala 
1               5                   10                  15      


Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala Gln Phe Ala Pro 
            20                  25                  30          


Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro His Pro His Pro 
        35                  40                  45              


Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu His Thr Leu Asn 
    50                  55                  60                  


Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser Pro Ala Asp Thr 
65                  70                  75                  80  


Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr Asp Asp Ala Ala 
                85                  90                  95      


Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu Asn Thr Glu Asn 
            100                 105                 110         


Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe 
        115                 120                 125             


Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu 
    130                 135                 140                 


Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe 
145                 150                 155                 160 


Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu 
                165                 170                 175     


His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr 
            180                 185                 190         


Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro Tyr Thr Asn Gly 
        195                 200                 205             


Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser Pro Glu Phe Tyr 
    210                 215                 220                 


Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu Gly Ser Ser Met 
225                 230                 235                 240 


Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala Met Pro Gly Phe 
                245                 250                 255     


Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg Gly Ala His Leu 
            260                 265                 270         


Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg Ala Ala Ala Pro 
        275                 280                 285             


Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr Gln Asp Gly Phe 
    290                 295                 300                 


Tyr Gly Ala Asp Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln 
305                 310                 315                 320 


Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp Ser Tyr Gly Arg Val 
                325                 330                 335     


Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala Pro Ala Pro Thr Tyr 
            340                 345                 350         


Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu Thr Asp Ala Lys Thr 
        355                 360                 365             


Arg Ser His Ala Asp Asp Val Gly Leu Val Leu Ser Ser Leu Gln Ala 
    370                 375                 380                 


Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390                 395         


<210>  1771
<211>  1919
<212>  DNA
<213>  Homosapiens

<400>  1771
tttaatcagg aatgtaattt tagatagagg cggtaatgga gtggtaggcc acacataaca     60

gaatgaagct tccccaacgt ggattcccag actatggaag tgctggcctc cctgctccca    120

gctgagccgg gaaaactctg ccccactcca agaggtgctt ctcaaagatg attcctgatc    180

ccaggcatgt cctgtgtcct gtcaccaatc ctggtgcttc atcgtccttt aaaatccaaa    240

cgaggtgatc tagtgttctt cctctgcgtc ctctggtctt ctagcatcct ggataggccg    300

tgtatgttta gaaagagggg ctccaccctg tgcccgccta agatgatggc tcatttatca    360

agaccaggct ggaggctcag ctaccagagc ttctgttgtt tgggaggaag gctgccagca    420

gcagatgttt gtcctcgcct cagctccctg cagcctttga gctccatctg ccgcacactc    480

gggcacagct gccagtgctt cccctccgtg ctcacctttc acctctcacg gaggctgggg    540

tttcatgcat ctgggcccaa cagagagatg gtgacccaga ccctgcgatc ctggtgccac    600

aatccttccc aacagcttgc tgggcatctt tctgcagtag cctgtcagca tgctggaagc    660

agcaccgatg gaggttgttg agcagggttg caattgtagc ccgtcacttt ggtcttggtg    720

ttccatcttg ttagggcaag agagtcagag cacacacagc catctcctgg ctggatcatc    780

tggtggagtg ggagtgtgca cgtgcccacc cccatttcta aataagatat gcattgtctc    840

agggcctttg caatgtccac tccctagtcc tcaatgctct tccccattgg tcatcccaga    900

gctcatctca aatgtcaccc tttagagggg cagctgtcag tcttcccagt taaagcatat    960

gccaaccccc tcatcactcc tggtctcaac aacctcttta tttccctcat tgctattatt   1020

ttcatctgta attctcatct ttataatatc tcttgaatga atctttagga ggattactct   1080

tcctagagtg tgcaaaacgg attgcaggga tggtgagagg tgggcggaaa tgttggaaag   1140

gggacaaggg tggaattggt agcactgatc ttgttgagag aggattggcc ctggaaaaag   1200

aaagtagcaa tggagcagga agtaattaga catagaagag agctcttcac gtgggaggtg   1260

aggagaatcg gtgttgggat tgtgtgttag gactgaggaa ggaggaggag gaggatgccc   1320

agctttctaa actgggtatt tgagtggatg ggggtgactt gccgaaaata aagaatggtt   1380

tgagaagaaa gatgctgtgc tcatcttgga aatgttgagt tttgggcccc tgtagaagac   1440

ccagctgaga tttgcaggtc tgcatcaaat ggagaattca tcagagaggc aatggtactc   1500

aaaaccatga cagtgaaagg tgcttcccta ggagagaggc aggataaaaa aataaggtgg   1560

cccaaaatta ggatggccac acatcccagt tagccaggat attcctgcct tatacctgtt   1620

gttccaccat aatttctaat ggcccccgcc cccctacttt cactttcact tgtctcagtg   1680

aactatatcg tcaccctacc cgcatgagaa ggttggggaa attcagagtt cataggaggg   1740

cataagaacc cactgaaaaa aactgagtat gagcagaagg gtagaaagaa aaaccggggt   1800

agtgttgggt aatgtatgcc aagggtagaa aattgacaag agaagaatca ttcatgtcaa   1860

atgggtcaca gaggtgaagt catgcaagtg tcaagagctg tgcattggat ttagctacc    1919


<210>  1772
<211>  164
<212>  PRT
<213>  Homosapiens

<400>  1772

Met Ser Cys Val Leu Ser Pro Ile Leu Val Leu His Arg Pro Leu Lys 
1               5                   10                  15      


Ser Lys Arg Gly Asp Leu Val Phe Phe Leu Cys Val Leu Trp Ser Ser 
            20                  25                  30          


Ser Ile Leu Asp Arg Pro Cys Met Phe Arg Lys Arg Gly Ser Thr Leu 
        35                  40                  45              


Cys Pro Pro Lys Met Met Ala His Leu Ser Arg Pro Gly Trp Arg Leu 
    50                  55                  60                  


Ser Tyr Gln Ser Phe Cys Cys Leu Gly Gly Arg Leu Pro Ala Ala Asp 
65                  70                  75                  80  


Val Cys Pro Arg Leu Ser Ser Leu Gln Pro Leu Ser Ser Ile Cys Arg 
                85                  90                  95      


Thr Leu Gly His Ser Cys Gln Cys Phe Pro Ser Val Leu Thr Phe His 
            100                 105                 110         


Leu Ser Arg Arg Leu Gly Phe His Ala Ser Gly Pro Asn Arg Glu Met 
        115                 120                 125             


Val Thr Gln Thr Leu Arg Ser Trp Cys His Asn Pro Ser Gln Gln Leu 
    130                 135                 140                 


Ala Gly His Leu Ser Ala Val Ala Cys Gln His Ala Gly Ser Ser Thr 
145                 150                 155                 160 


Asp Gly Gly Cys 
                


<210>  1773
<211>  3201
<212>  DNA
<213>  Homosapiens

<400>  1773
cagcgcgcgg cggcggcggc agaggctgaa gcagaagccg cggcggagcc ggggaagcgg     60

gggcgctgca gacggagcag gtgccgccgg cgggtccgcg cgcccccctc ggtccccttg    120

cctgaggctg aggggggggc ggtggtgggg gggccactcg gactcggcgg gcagcgtggg    180

gcggggggcc atgcggccgg gctcccccct ggcgcagcgg gacagcggcc agggccgggg    240

gcgcagcggc gtcgcttcat gcagccgggg cggctgggca gcggcggcgg cggcggcggc    300

ggcggcggcg ggggcggcgg ctgaaaccat gtccgggcag cgccgggggc tgccgccgcc    360

gccgccgccg ccgcgagccg ggagccgcga tggcccggtg gcccgcacct cctccgcctc    420

cgcctccgcc tccacctctg gccgcgccgc cgccgcccgg cgcctctgct aaggggccgc    480

cggcgcgcaa gctgcttttt atgtgcacct tgtccctgtc tgtcacctac ctgtgctaca    540

gcctcctggg cggctcgggc tccctgcaat tccctctggc gctgcaggag tcgccgggcg    600

ccgccgccga gcccccgccg agcccgccgc caccctctct gctgcctacc cccgtgcgcc    660

tcggcgcccc ctcgcagccg cccgcgccgc cgccgctgga caacgcgagc cacggggagc    720

cgcccgagcc cccagagcag ccagccgccc ccgggaccga cggctggggg ctgccgagcg    780

gcggcggagg cgcccgggac gcctggctcc ggaccccgct ggcccccagc gagatgatca    840

cggctcagag cgcgctgccg gagagggaag cgcaggagtc cagcaccacc gacgaggatc    900

tcgcaggccg gagagcggcc aacgggagca gcgagagggg cggcgccgtc agcacccccg    960

actatgggga gaagaagctg ccacaggcgc tcatcatcgg ggtcaagaaa ggagggaccc   1020

gcgcgctgct ggaggcgatc cgcgtgcacc cggacgtgcg ggcggtgggc gtagagccgc   1080

acttcttcga caggaactac gaaaaggggt tggagtggta cagaaatgtg atgcccaaga   1140

ctttggatgg gcaaataacc atggagaaga ctccaagtta ctttgtgaca aatgaggctc   1200

ccaagcgcat tcactccatg gccaaggaca tcaaactgat tgtggtggtg agaaaccccg   1260

tgaccagggc catctctgac tacacgcaga cactgtcaaa gaaacccgag atccccacct   1320

ttgaggtgct ggccttcaaa aaccggaccc tcgggctgat cgatgcttcc tggagtgcca   1380

ttcgaatagg gatctatgcg ctgcatctgg aaaactggct ccagtatttc cccctctccc   1440

agatcctctt tgtcagtggt gagcgactca ttgtggaccc cgccggggaa atggccaaag   1500

tacaggattt tctaggcctc aaacgtgttg tgactaagaa gcatttctat ttcaacaaaa   1560

ccaaggggtt cccttgccta aagaagccag aagacagcag tgccccgagg tgcttaggca   1620

agagcaaagg tcggactcat cctcgcattg acccagatgt catccacaga ctgaggaaat   1680

tctacaaacc cttcaacttg atgttttacc aaatgactgg tcaagatttt cagtgggaac   1740

aggaagaggg tgataaatga ggctagagag gcagaggaag gctagtcaat aagctaagga   1800

ggctccttgc ctgagtcctt gaatacccca gcttctgcag cttcacttgc tggagtgcca   1860

agtagatctc ctcctccttc atgcagccag gattgcctcc agtgctgtta gcttaggcaa   1920

acaggtggat cccatggcat ccccatggag gaaccaggcc catctgggca gcagcatctg   1980

gttgaccaga tggccaccag aacccactgt tcattcttat cttctgctag ttaatatagc   2040

ctgaagacag aggataaata gttgtcaatg tcagagacag tgctattaat gtatatgtga   2100

gcgacaaaaa aggtctgctt tataggggtt ctcactctag cttggggagc ccagggttct   2160

agccctgtat ctgtcatggg cacctgctgt ctaaacctct gcttgggctt ctccccagaa   2220

tgcactttgt ggctgagtgc tccaggactc ctagggagca agctcctccc tctaaggtgt   2280

ttctagtctt ctctttaaag gtctcatccc acaacccctg acttcctccc tccccacatc   2340

atgaaggcag aggcatgcac attcctcact gaaaaagaaa acacacaccc acccacacac   2400

acacacacag aagaaaatga aagctgacac acctcgaagc cttctttcca agagccctct   2460

aaatggggtt gggtctcact cttcatgagt atcctgggtt gtgcagaagc ttagcatatg   2520

cccttgtgtt cggatcaggc ccacagggct gctcaaagag tagagtaatt gtaaccgagg   2580

tcagagctct ggggttggca gagatgagtg gccatatctg ggggtaaaag aagaaatcct   2640

gtcctcttgg tgggaggtta ccttacctga agaccatctc tcccaagcac tgtagttctg   2700

agcatgtttt tggggtggac tctgtcccct agggtcccta gaagggcaaa gaccagagag   2760

ttgacaagtc tgttattagg aataatcctt agccatgtaa tggagaaagg agcagtcagc   2820

attcttccaa tttgccccac caccacctcc tcgggcttca ttttctctat ttagagatgg   2880

cagagagtga ggtagtggcg agaaagctga ctccattcat cagatccagt ttatgagggt   2940

tgggggtgag caagggctgt ctgcagaaac ccccatcaag agctgctgaa tgaagtgtcc   3000

cttcccatca gtttgattca attaaaatgc atcatttgac ataaagcact tgttcacaga   3060

tctccaaaac caggaattgt tctagtaaaa ctggaaattt gtatgagtgg ggggagttaa   3120

atctgttcag ctgttattaa actgtcattt ctcccgctaa atgaaaaccg tgttgttata   3180

aagcttaatg caacctgatt a                                             3201


<210>  1774
<211>  456
<212>  PRT
<213>  Homosapiens

<400>  1774

Met Ala Arg Trp Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Leu Ala Ala Pro Pro Pro Pro Gly Ala Ser Ala Lys Gly Pro Pro Ala 
            20                  25                  30          


Arg Lys Leu Leu Phe Met Cys Thr Leu Ser Leu Ser Val Thr Tyr Leu 
        35                  40                  45              


Cys Tyr Ser Leu Leu Gly Gly Ser Gly Ser Leu Gln Phe Pro Leu Ala 
    50                  55                  60                  


Leu Gln Glu Ser Pro Gly Ala Ala Ala Glu Pro Pro Pro Ser Pro Pro 
65                  70                  75                  80  


Pro Pro Ser Leu Leu Pro Thr Pro Val Arg Leu Gly Ala Pro Ser Gln 
                85                  90                  95      


Pro Pro Ala Pro Pro Pro Leu Asp Asn Ala Ser His Gly Glu Pro Pro 
            100                 105                 110         


Glu Pro Pro Glu Gln Pro Ala Ala Pro Gly Thr Asp Gly Trp Gly Leu 
        115                 120                 125             


Pro Ser Gly Gly Gly Gly Ala Arg Asp Ala Trp Leu Arg Thr Pro Leu 
    130                 135                 140                 


Ala Pro Ser Glu Met Ile Thr Ala Gln Ser Ala Leu Pro Glu Arg Glu 
145                 150                 155                 160 


Ala Gln Glu Ser Ser Thr Thr Asp Glu Asp Leu Ala Gly Arg Arg Ala 
                165                 170                 175     


Ala Asn Gly Ser Ser Glu Arg Gly Gly Ala Val Ser Thr Pro Asp Tyr 
            180                 185                 190         


Gly Glu Lys Lys Leu Pro Gln Ala Leu Ile Ile Gly Val Lys Lys Gly 
        195                 200                 205             


Gly Thr Arg Ala Leu Leu Glu Ala Ile Arg Val His Pro Asp Val Arg 
    210                 215                 220                 


Ala Val Gly Val Glu Pro His Phe Phe Asp Arg Asn Tyr Glu Lys Gly 
225                 230                 235                 240 


Leu Glu Trp Tyr Arg Asn Val Met Pro Lys Thr Leu Asp Gly Gln Ile 
                245                 250                 255     


Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Asn Glu Ala Pro Lys 
            260                 265                 270         


Arg Ile His Ser Met Ala Lys Asp Ile Lys Leu Ile Val Val Val Arg 
        275                 280                 285             


Asn Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr Leu Ser Lys 
    290                 295                 300                 


Lys Pro Glu Ile Pro Thr Phe Glu Val Leu Ala Phe Lys Asn Arg Thr 
305                 310                 315                 320 


Leu Gly Leu Ile Asp Ala Ser Trp Ser Ala Ile Arg Ile Gly Ile Tyr 
                325                 330                 335     


Ala Leu His Leu Glu Asn Trp Leu Gln Tyr Phe Pro Leu Ser Gln Ile 
            340                 345                 350         


Leu Phe Val Ser Gly Glu Arg Leu Ile Val Asp Pro Ala Gly Glu Met 
        355                 360                 365             


Ala Lys Val Gln Asp Phe Leu Gly Leu Lys Arg Val Val Thr Lys Lys 
    370                 375                 380                 


His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu Lys Lys Pro 
385                 390                 395                 400 


Glu Asp Ser Ser Ala Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Thr 
                405                 410                 415     


His Pro Arg Ile Asp Pro Asp Val Ile His Arg Leu Arg Lys Phe Tyr 
            420                 425                 430         


Lys Pro Phe Asn Leu Met Phe Tyr Gln Met Thr Gly Gln Asp Phe Gln 
        435                 440                 445             


Trp Glu Gln Glu Glu Gly Asp Lys 
    450                 455     


<210>  1775
<211>  4098
<212>  DNA
<213>  Homosapiens

<400>  1775
gacggtcggc tgacaggctc cacagagctc cactcacgct caggccctgg acggacaggc     60

agtccaacgg aacagaaaca tccctcagcc ccacaggcac gatctgttcc tcctgggaag    120

atgcagaggc tcatgatgct cctcgccaca tcgggcgcct gcctgggcct gctggcagtg    180

gcagcagtgg cagcagcagg tgctaaccct gcccaacggg acacccacag cctgctgccc    240

acccaccggc gccaaaagag agattggatt tggaaccaga tgcacattga tgaagagaaa    300

aacacctcac ttccccatca tgtaggcaag atcaagtcaa gcgtgagtcg caagaatgcc    360

aagtacctgc tcaaaggaga atatgtgggc aaggtcttcc gggtcgatgc agagacagga    420

gacgtgttcg ccattgagag gctggaccgg gagaatatct cagagtacca cctcactgct    480

gtcattgtgg acaaggacac tggtgaaaac ctggagactc cttccagctt caccatcaaa    540

gttcatgacg tgaacgacaa ctggcctgtg ttcacgcatc ggttgttcaa tgcgtccgtg    600

cctgagtcgt cggctgtggg gacctcagtc atctctgtga cagcagtgga tgcagacgac    660

cccactgtgg gagaccacgc ctctgtcatg taccaaatcc tgaaggggaa agagtatttt    720

gccatcgata attctggacg tattatcaca ataacgaaaa gcttggaccg agagaagcag    780

gccaggtatg agatcgtggt ggaagcgcga gatgcccagg gcctccgggg ggactcgggc    840

acggccaccg tgctggtcac tctgcaagac atcaatgaca acttcccctt cttcacccag    900

accaagtaca catttgtcgt gcctgaagac acccgtgtgg gcacctctgt gggctctctg    960

tttgttgagg acccagatga gccccagaac cggatgacca agtacagcat cttgcggggc   1020

gactaccagg acgctttcac cattgagaca aaccccgccc acaacgaggg catcatcaag   1080

cccatgaagc ctctggatta tgaatacatc cagcaataca gcttcatcgt cgaggccaca   1140

gaccccacca tcgacctccg atacatgagc cctcccgcgg gaaacagagc ccaggtcatt   1200

atcaacatca cagatgtgga cgagcccccc attttccagc agcctttcta ccacttccag   1260

ctgaaggaaa accagaagaa gcctctgatt ggcacagtgc tggccatgga ccctgatgcg   1320

gctaggcata gcattggata ctccatccgc aggaccagtg acaagggcca gttcttccga   1380

gtcacaaaaa agggggacat ttacaatgag aaagaactgg acagagaagt ctacccctgg   1440

tataacctga ctgtggaggc caaagaactg gattccactg gaacccccac aggaaaagaa   1500

tccattgtgc aagtccacat tgaagttttg gatgagaatg acaatgcccc ggagtttgcc   1560

aagccctacc agcccaaagt gtgtgagaac gctgtccatg gccagctggt cctgcagatc   1620

tccgcaatag acaaggacat aacaccacga aacgtgaagt tcaaattcac cttgaatact   1680

gagaacaact ttaccctcac ggataatcac gataacacgg ccaacatcac agtcaagtat   1740

gggcagtttg accgggagca taccaaggtc cacttcctac ccgtggtcat ctcagacaat   1800

gggatgccaa gtcgcacggg caccagcacg ctgaccgtgg ccgtgtgcaa gtgcaacgag   1860

cagggcgagt tcaccttctg cgaggatatg gccgcccagg tgggcgtgag catccaggca   1920

gtggtagcca tcttactctg catcctcacc atcacagtga tcaccctgct catcttcctg   1980

cggcggcggc tccggaagca ggcccgcgcg cacggcaaga gcgtgccgga gatccacgag   2040

cagctggtca cctacgacga ggagggcggc ggcgagatgg acaccaccag ctacgatgtg   2100

tcggtgctca actcggtgcg ccgcggcggg gccaagcccc cgcggcccgc gctggacgcc   2160

cggccttccc tctatgcgca ggtgcagaag ccaccgaggc acgcgcctgg ggcacacgga   2220

gggcccgggg agatggcagc catgatcgag gtgaagaagg acgaggcgga ccacgacggc   2280

gacggccccc cctacgacac gctgcacatc tacggctacg agggctccga gtccatagcc   2340

gagtccctca gctccctggg caccgactca tccgactctg acgtggatta cgacttcctt   2400

aacgactggg gacccaggtt taagatgctg gctgagctgt acggctcgga cccccgggag   2460

gagctgctgt attaggcggc cgaggtcact ctgggcctgg ggacccaaac cccctgcagc   2520

ccaggccagt cagacgccag gcaccacagc ctccaaaaat ggcagtgact ccccagccca   2580

gcaccccttc ctcgtgggtc ccagagacct catcagcctt gggatagcaa actccaggtt   2640

cctgaaatat ccaggaatat atgtcagtga tgactattct caaatgctgg caaatccagg   2700

ctggtgttct gtctgggctc agacatccac ataaccctgt cacccacaga ccgccgtcta   2760

actcaaagac ttcctctggc tccccaaggc tgcaaagcaa aacagactgt gtttaactgc   2820

tgcagggtct ttttctaggg tccctgaacg ccctggtaag gctggtgagg tcctggtgcc   2880

tatctgcctg gaggcaaagg cctggacagc ttgacttgtg gggcaggatt ctctgcagcc   2940

cattcccaag ggagactgac catcatgccc tctctcggga gccctagccc tgctccaact   3000

ccatactcca ctccaagtgc cccaccactc cccaacccct ctccaggcct gtcaagaggg   3060

aggaaggggc cccatggcag ctcctgacct tgggtcctga agtgacctca ctggcctgcc   3120

atgccagtaa ctgtgctgta ctgagcactg aaccacattc agggaaatgg cttattaaac   3180

tttgaagcaa ctgtgaattc attctggagg ggcagtggag atcaggagtg acagatcaca   3240

gggtgagggc cacctccaca cccaccccct ctggagaagg cctggaagag ctgagacctt   3300

gctttgagac tcctcagcac ccctccagtt ttgcctgaga aggggcagat gttcccggag   3360

cagaagacgt ctccccttct ctgcctcacc tggtcgccaa tccatgctct ctttcttttc   3420

tctgtctact ccttatccct tggtttagag gaacccaaga tgtggccttt agcaaaactg   3480

gacaatgtcc aaacccactc atgactgcat gacggagccg agccatgtgt ctttacacct   3540

cgctgttgtc acatctcagg gaactgaccc tcaggcacac cttgcagaag gcaaggccct   3600

gccctgccca acctctgtgg tcacccatgc atcttccact ggaacgtttc actgcaaaca   3660

caccttggag aagtggcatc agtcaacaga gaggggcagg gaaggagaca ccaagctcac   3720

ccttcgtcat ggaccgaggt tcccactctg ggcaaagccc ctcacactgc aagggattgt   3780

agataacact gacttgtttg ttttaaccaa taactagctt cttataatga tttttttact   3840

aatgatactt acaagtttct agctctcaca gacatataga ataagggttt ttgcataata   3900

agcaggttgt tatttaggtt aacaatatta attcaggttt tttagttgga aaaacaattc   3960

ctgtaacctt ctattttcta taattgtagt aattgctcta cagataatgt ctatatattg   4020

gccaaactgg tgcatgacaa gtactgtatt tttttatacc taaataaaga aaaatcttta   4080

gcctgggcaa caaaaaaa                                                 4098


<210>  1776
<211>  784
<212>  PRT
<213>  Homosapiens

<400>  1776

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210>  1777
<211>  6392
<212>  DNA
<213>  Homosapiens

<400>  1777
atcttttttc atcttctagc tgtagctcgg gctgcttgtc ggcttggcct ccccctcccc     60

cctttgctct ctgcctcgtc tttccccagg acttcgctat tttgcttttt taaaaaaagg    120

caagaaagaa ctaaactccc ccctccctct cctccagtcg ggctgcacct ctgccttgca    180

ctttgcacag aggtagagag cgcgcgaggg agagagagga aagaaaaaaa ataataaaga    240

gagccaagca gaagaggagg cgagaagcat gaagtgttaa ctcccccgtg ccaaggcccg    300

cgccgcccgg acagacgccc gccgcgcctc cagccccgag cggacgccgc gcgcgccctg    360

cctgcagccc gggccggcga ggcgagccct tccttatgca aagcgcgcag cggagcggcg    420

agcgggggac gccgcgcacc gggccgggct cctccagctt cgccgccgca gccaccaccg    480

ccgccaccgc agctcgcgga ggatcttccc gagcctgaag ccgccggctc ggcgcgcaag    540

gaggcgagcg agcaaggagg ggccggggcg agcgagggag cacattggcg tgagcagggg    600

ggagggaggg cgggcgcggg gggcgcgggc agggcggggg ggtgtgtgtg tgagcgcgct    660

cggaggtttc gggccagcca ccgccgcgca agctagaagc gccccagccc ggcaagctgg    720

ctcacccgct ggccacccag cacagcccgc tggcccctct cctgcagccc atctggcgga    780

gcggcggcgg cggcggcggc ggcaggagaa tggcatcaga actggcaatg agcaactccg    840

acctgcccac cagtcccctg gccatggaat atgttaatga cttcgatctg atgaagtttg    900

aagtgaaaaa ggaaccggtg gagaccgacc gcatcatcag ccagtgcggc cgtctcatcg    960

ccgggggctc gctgtcctcc acccccatga gcacgccgtg cagctcggtg cccccttccc   1020

ccagcttctc ggcgcccagc ccgggctcgg gcagcgagca gaaggcgcac ctggaagact   1080

actactggat gaccggctac ccgcagcagc tgaaccccga ggcgctgggc ttcagccccg   1140

aggacgcggt cgaggcgctc atcagcaaca gccaccagct ccagggcggc ttcgatggct   1200

acgcgcgcgg ggcgcagcag ctggccgcgg cggccggggc cggtgccggc gcctccttgg   1260

gcggcagcgg cgaggagatg ggccccgccg ccgccgtggt gtccgccgtg atcgccgcgg   1320

ccgccgcgca gagcggcgcg ggcccgcact accaccacca ccaccaccac gccgccggcc   1380

accaccacca cccgacggcc ggcgcgcccg gcgccgcggg cagcgcggcc gcctcggccg   1440

gtggcgctgg gggcgcgggc ggcggtggcc cggccagcgc tgggggcggc ggcggcggcg   1500

gcggcggcgg aggcggcggg ggcgcggcgg gggcgggggg cgccctgcac ccgcaccacg   1560

ccgccggcgg cctgcacttc gacgaccgct tctccgacga gcagctggtg accatgtctg   1620

tgcgcgagct gaaccggcag ctgcgcgggg tcagcaagga ggaggtgatc cggctgaagc   1680

agaagaggcg gaccctgaaa aaccgcggct atgcccagtc ctgccgcttc aagagggtgc   1740

agcagagaca cgtcctggag tcggagaaga accagctgct gcagcaagtc gaccacctca   1800

agcaggagat ctccaggctg gtgcgcgaga gggacgcgta caaggagaaa tacgagaagt   1860

tggtgagcag cggcttccga gaaaacggct cgagcagcga caacccgtcc tctcccgagt   1920

ttttcatgtg agtctgacac gcgattccag ctagccaccc tgataagtgc tccgcggggg   1980

tccggctcgg gtgtgggctt gctagttcta gagccatgct cgccaccacc tcaccacccc   2040

cacccccacc gagtttggcc cccttggccc cctacacaca cacaaacccg cacgcacaca   2100

ccacacacac acacacacac acacacacac cccacaccct gctcgagttt gtggtggtgg   2160

tggctgtttt aaactgggga gggaatgggt gtctggctca tggattgcca atctgaaatt   2220

ctccataact tgctagcttg tttttttttt ttttttacac ccccccgccc cacccccgga   2280

cttgcacaat gttcaatgat ctcagcagag ttcttcatgt gaaacgttga tcacctttga   2340

agcctgcatc attcacatat tttttcttct tcttcccctt cagttcatga actggtgttc   2400

attttctgtg tgtgtgtgtg ttttattttg tttggatttt tttttttaat tttactttta   2460

gagcttgctg tgttgcccac cttttttcca acctccaccc tcactccttc tcaacccatc   2520

tcttccgaga tgaaagaaaa aaaaaagcaa agtttttttt tcttctcctg agttcttcat   2580

gtgagattga gcttgcaaag gaaaaaaaaa tgtgaaatgt tatagacttg cagcgtgccg   2640

agttccatcg ggtttttttt ttagcattgt tatgctaaaa tagagaaaaa aatcctcatg   2700

aaccttccac aatcaagcct gcatcaacct tctgggtgtg acttgtgagt tttggccttg   2760

tgatgccaaa tctgagagtt tagtctgcca ttaaaaaaac tcattctcat ctcatgcatt   2820

attatgcttg ctactttgtc ttagcaacaa tgaactataa ctgtttcaaa gactttatgg   2880

aaaagagaca ttatattaat aaaaaaaaaa agcctgcatg ctggacatgt atggtataat   2940

tattttttcc tttttttttc cttttggctt ggaaatggac gttcgaagac ttatagcatg   3000

gcattcatac ttttgtttta ttgcctcatg acttttttga gtttagaaca aaacagtgca   3060

accgtagagc cttcttccca tgaaattttg catctgctcc aaaactgctt tgagttactc   3120

agaacttcaa cctcccaatg cactgaaggc attccttgtc aaagatacca gaatgggtta   3180

cacatttaac ctggcaaaca ttgaagaact cttaatgttt tctttttaat aagaatgacg   3240

ccccactttg gggactaaaa ttgtgctatt gccgagaagc agtctaaaat ttatttttta   3300

aaaagagaaa ctgccccatt atttttggtt tgttttattt ttattttata ttttttggct   3360

tttggtcatt gtcaaatgtg gaatgctctg ggtttctagt atataattta attctagttt   3420

ttataatctg ttagcccagt taaaatgtat gctacagata aaggaatgtt atagataaat   3480

ttgaaagagt taggtctgtt tagctgtaga ttttttaaac gattgatgca ctaaattgtt   3540

tactattgtg atgttaaggg gggtagagtt tgcaagggga ctgtttaaaa aaagtagctt   3600

atacagcatg tgcttgcaac ttaaatataa gttgggtatg tgtagtcttt gctataccac   3660

tgactgtatt gaaaaccaaa gtattaagag gggaaacgcc cctgtttata tctgtagggg   3720

tattttacat tcaaaaatgt atgttttttt ttcttttcaa aattaaagta tttgggactg   3780

aattgcacta agatataacc tgcaagcata taatacaaaa aaaaattgca aaactgttta   3840

gaacgctaat aaaatttatg cagttataaa aatggcatta ctgcacagtt ttaagatgat   3900

gcagattttt ttacagttgt attgtggtgc agaactggat tttctgtaac ttaaaaaaaa   3960

atccacagtt ttaaaggcaa taatcagtaa atgttatttt cagggactga catcctgtct   4020

ttaaaaagaa atgaaaagta aatcttacca caataaatat aaaaaaatct tgtcagttac   4080

ttttctttta catattttgc tgtgcaaaat tgttttatat cttgagttac taactaacca   4140

cgcgtgttgt tcctatgtgc ttttctttca ttttcaattc tggttatatc aagaaaagaa   4200

taatctacaa taataaacgg catttttttt tgattctgta ctcagtttct tagtgtacag   4260

tttaactggg cccaacaacc tcgttaaaag tgtaaaatgc atccttttct ccagtggaag   4320

gattcctgga ggaataggga gacagtaatt cagggtgaaa ttataggctg ttttttgaag   4380

tgaggaggct ggccccatat actgattagc aatatttaat atagatgtaa attatgacct   4440

catttttttc tccccaaagt tttcagtttt caaatgagtt gagccataat tgcccttggt   4500

aggaaaaaca aaacaaaaca gtggaactag gcttcctgag catggcccta cacttctgat   4560

caggagcaaa gccatccata gacagaggag ccggacaaat atggcgcatc agaggtggct   4620

tgcgcacata tgcattgaac ggtaaagaga aacagcgctt gccttttcac taaagttgac   4680

tatttttcct tcttctctta cacaccgaga ttttcttgtt agcaaggcct gacaagattt   4740

aacataaaca tgacaaatca tagttgtttg ttttgttttg cttttctctt taacactgaa   4800

gatcatttgt cttaaatagg aaaaagaaaa tccactcctt acttccatat ttccaagtac   4860

atatctggtt taaactatgt tatcaaatca tatttcaccg tgaatattca gtggagaact   4920

tctctacctg gatgagctag taatgatttc agatcatgct atccccagaa ataaaagcaa   4980

aaaataatac ctgtgtggaa tataggctgt gctttgattt actggtattt accccaaaat   5040

aggctgtgta tgggggctga cttaaagatc ccttggaaag actcaaaact accttcacta   5100

gtaggactcc taagcgctga cctattttta aatgacacaa attcatgaaa ctaatgttac   5160

aaattcatgc agtttgcact cttagtcatc ttcccctagc acaccaatag aatgttagac   5220

aaagccagca ctgttttgaa aatacagcca aacacgatga cttttgtttt gttttctgcc   5280

gttcttaaaa gaaaaaaaga taatattgca actctgactg aaagacttat ttttaagaaa   5340

acaggttgtg tttggtgctg ctaagttctg gccagtttat catctggcct tcctgcctat   5400

tttttacaaa acacgaagac agtgtgtaac ctcgacattt tgaccttcct ttatgtgcta   5460

gtttagacag gctcctgaat ccacacttaa ttttgcttaa caaaagtctt aatagtaaac   5520

ctcccctcat gagcttgaag tcaagtgttc ttgacttcag atatttcttt cctttttttt   5580

tttttttcct catcacaact aagagataca caaactctga agaagcagaa atggagagaa   5640

tgcttttaac aaaaaagcat ctgatgaaag attttaggca aacattctca aaataagagt   5700

gatattctgg atgtagttat tgcagttatc tcatgacaaa tgaggcctgg attggaagga   5760

aaatatagtt gtgtagaatt aagcattttg ataggaatct acaaggtagt tgaatataat   5820

aagcaggttt gggcccccaa actttagaaa atcaaatgca aaggtgctgg caaaaatgag   5880

gtttgagtgg ctggctgtaa gagaaggtta actcctagta aaaggcattt ttagaaataa   5940

caattactga aaactttgaa gtatagtggg agtagcaaac aaatacatgt tttttttttc   6000

ttacaaagaa ctcctaaatc ctgagtaagt gccattcatt acaataagtc tctaaattta   6060

aaaaaaaaaa aatcatatga ggaaatctag ctttcccctt tacgctgcgt ttgatctttg   6120

tctaaatagt gttaaaattc ctttcattcc aattacagaa ctgagcccac tcgcaagttg   6180

gagccatcag tgggatacgc cacattttgg aagccccagc atcgtgtact taccagtgtg   6240

ttcacaaaat gaaatttgtg tgagagctgt acattaaaaa aaatcatcat tattattatt   6300

atttgcagtc atggagaacc acctacccct gacttctgtt tagtctcctt tttaaataaa   6360

aattactgtg ttagagaaaa aaaaaaaaaa aa                                 6392


<210>  1778
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  1778

Met Ala Ser Glu Leu Ala Met Ser Asn Ser Asp Leu Pro Thr Ser Pro 
1               5                   10                  15      


Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
            20                  25                  30          


Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
        35                  40                  45              


Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
    50                  55                  60                  


Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser 
65                  70                  75                  80  


Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                85                  90                  95      


Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
            100                 105                 110         


Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
        115                 120                 125             


Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
    130                 135                 140                 


Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
145                 150                 155                 160 


Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                165                 170                 175     


Ala Gly Pro His Tyr His His His His His His Ala Ala Gly His His 
            180                 185                 190         


His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
        195                 200                 205             


Ser Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Leu His Pro His His Ala Ala Gly Gly Leu His 
                245                 250                 255     


Phe Asp Asp Arg Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg 
            260                 265                 270         


Glu Leu Asn Arg Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg 
        275                 280                 285             


Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser 
    290                 295                 300                 


Cys Arg Phe Lys Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys 
305                 310                 315                 320 


Asn Gln Leu Leu Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg 
                325                 330                 335     


Leu Val Arg Glu Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val 
            340                 345                 350         


Ser Ser Gly Phe Arg Glu Asn Gly Ser Ser Ser Asp Asn Pro Ser Ser 
        355                 360                 365             


Pro Glu Phe Phe Met 
    370             


<210>  1779
<211>  2161
<212>  DNA
<213>  Homosapiens

<400>  1779
atcttttttc atcttctagc tgtagctcgg gctgcttgtc ggcttggcct ccccctcccc     60

cctttgctct ctgcctcgtc tttccccagg acttcgctat tttgcttttt taaaaaaagg    120

caagaaagaa ctaaactccc ccctccctct cctccagtcg ggctgcacct ctgccttgca    180

ctttgcacag aggtagagag cgcgcgaggg agagagagga aagaaaaaaa ataataaaga    240

gagccaagca gaagaggagg cgagaagcat gaagtgttaa ctcccccgtg ccaaggcccg    300

cgccgcccgg acagacgccc gccgcgcctc cagccccgag cggacgccgc gcgcgccctg    360

cctgcagccc gggccggcga ggcgagccct tccttatgca aagcgcgcag cggagcggcg    420

agcgggggac gccgcgcacc gggccgggct cctccagctt cgccgccgca gccaccaccg    480

ccgccaccgc agctcgcgga ggatcttccc gagcctgaag ccgccggctc ggcgcgcaag    540

gaggcgagcg agcaaggagg ggccggggcg agcgagggag cacattggcg tgagcagggg    600

ggagggaggg cgggcgcggg gggcgcgggc agggcggggg ggtgtgtgtg tgagcgcgct    660

cggaggtttc gggccagcca ccgccgcgca agctagaagc gccccagccc ggcaagctgg    720

ctcacccgct ggccacccag cacagcccgc tggcccctct cctgcagccc atctggcgga    780

gcggcggcgg cggcggcggc ggcaggagaa tggcatcaga actggcaatg agcaactccg    840

acctgcccac cagtcccctg gccatggaat atgttaatga cttcgatctg atgaagtttg    900

aagtgaaaaa ggaaccggtg gagaccgacc gcatcatcag ccagtgcggc cgtctcatcg    960

ccgggggctc gctgtcctcc acccccatga gcacgccgtg cagctcggtg cccccttccc   1020

ccagcttctc ggcgcccagc ccgggctcgg gcagcgagca gaaggcgcac ctggaagact   1080

actactggat gaccggctac ccgcagcagc tgaaccccga ggcgctgggc ttcagccccg   1140

aggacgcggt cgaggcgctc atcagcaaca gccaccagct ccagggcggc ttcgatggct   1200

acgcgcgcgg ggcgcagcag ctggccgcgg cggccggggc cggtgccggc gcctccttgg   1260

gcggcagcgg cgaggagatg ggccccgccg ccgccgtggt gtccgccgtg atcgccgcgg   1320

ccgccgcgca gagcggcgcg ggcccgcact accaccacca ccaccaccac gccgccggcc   1380

accaccacca cccgacggcc ggcgcgcccg gcgccgcggg cagcgcggcc gcctcggccg   1440

gtggcgctgg gggcgcgggc ggcggtggcc cggccagcgc tgggggcggc ggcggcggcg   1500

gcggcggcgg aggcggcggg ggcgcggcgg gggcgggggg cgccctgcac ccgcaccacg   1560

ccgccggcgg cctgcacttc gacgaccgct tctccgacga gcagctggtg accatgtctg   1620

tgcgcgagct gaaccggcag ctgcgcgggg tcagcaagga ggaggtgatc cggctgaagc   1680

agaagaggcg gaccctgaaa aaccgcggct atgcccagtc ctgccgcttc aagagggtgc   1740

agcagagaca cgtcctggag tcggagaaga accagctgct gcagcaagtc gaccacctca   1800

agcaggagat ctccaggctg gtgcgcgaga gggacgcgta caaggagaaa tacgagaagt   1860

tggtgagcag cggcttccga gaaaacggct cgagcagcga caacccgtcc tctcccgagt   1920

ttttcataac tgagcccact cgcaagttgg agccatcagt gggatacgcc acattttgga   1980

agccccagca tcgtgtactt accagtgtgt tcacaaaatg aaatttgtgt gagagctgta   2040

cattaaaaaa aatcatcatt attattatta tttgcagtca tggagaacca cctacccctg   2100

acttctgttt agtctccttt ttaaataaaa attactgtgt tagagaaaaa aaaaaaaaaa   2160

a                                                                   2161


<210>  1780
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  1780

Met Ala Ser Glu Leu Ala Met Ser Asn Ser Asp Leu Pro Thr Ser Pro 
1               5                   10                  15      


Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
            20                  25                  30          


Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
        35                  40                  45              


Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
    50                  55                  60                  


Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser 
65                  70                  75                  80  


Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                85                  90                  95      


Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
            100                 105                 110         


Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
        115                 120                 125             


Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
    130                 135                 140                 


Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
145                 150                 155                 160 


Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                165                 170                 175     


Ala Gly Pro His Tyr His His His His His His Ala Ala Gly His His 
            180                 185                 190         


His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
        195                 200                 205             


Ser Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Leu His Pro His His Ala Ala Gly Gly Leu His 
                245                 250                 255     


Phe Asp Asp Arg Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg 
            260                 265                 270         


Glu Leu Asn Arg Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg 
        275                 280                 285             


Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser 
    290                 295                 300                 


Cys Arg Phe Lys Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys 
305                 310                 315                 320 


Asn Gln Leu Leu Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg 
                325                 330                 335     


Leu Val Arg Glu Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val 
            340                 345                 350         


Ser Ser Gly Phe Arg Glu Asn Gly Ser Ser Ser Asp Asn Pro Ser Ser 
        355                 360                 365             


Pro Glu Phe Phe Ile Thr Glu Pro Thr Arg Lys Leu Glu Pro Ser Val 
    370                 375                 380                 


Gly Tyr Ala Thr Phe Trp Lys Pro Gln His Arg Val Leu Thr Ser Val 
385                 390                 395                 400 


Phe Thr Lys 
            


<210>  1781
<211>  685
<212>  DNA
<213>  Homosapiens

<400>  1781
tttacctgct aggctcgtcc cacctgtgtg gagctcccat cgccctccag cgttgcgcag     60

cctgaaggga caggacggac aagcgggtgc ctccttctaa ttcatcttca ccattgtggt    120

tgtcaatatg gcatgcagaa ttatccctct ttccaggttt tccccaagga ccctggacaa    180

tgctggtttt tcctatgtgc accaccaaag ggcctatcca gcttctggag tctacctgga    240

ttcctgggct catggcccct tcctccatct tcaaaccagc aatggaaatg gaaatgaaag    300

caaaatggaa ggacgtgagg tccttatcct tggagatcct atggagtctc cacagacatt    360

ccttgaagaa atcagatgga gctgagcctg acactctaac cggttctctg ggtgtactgc    420

aaaggtctaa taaaaggcac ctttgcccgg ttgcttcaat tctaggaagc tgttcaatgt    480

ttgactatat ttctccatac tcatttgaaa acagttcatc aggttagttc agttgaatta    540

ttgctccttg ggagttttcc aaaccctgga tttccttcgg agagagctag attctattcc    600

attcttggaa ttcagctcct tgcccttctc tgtgaccccg gatcgcgaat gcagtaaaaa    660

taaaaatatc ctgctgcctc ctgca                                          685


<210>  1782
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  1782

Met Leu Val Phe Pro Met Cys Thr Thr Lys Gly Pro Ile Gln Leu Leu 
1               5                   10                  15      


Glu Ser Thr Trp Ile Pro Gly Leu Met Ala Pro Ser Ser Ile Phe Lys 
            20                  25                  30          


Pro Ala Met Glu Met Glu Met Lys Ala Lys Trp Lys Asp Val Arg Ser 
        35                  40                  45              


Leu Ser Leu Glu Ile Leu Trp Ser Leu His Arg His Ser Leu Lys Lys 
    50                  55                  60                  


Ser Asp Gly Ala Glu Pro Asp Thr Leu Thr Gly Ser Leu Gly Val Leu 
65                  70                  75                  80  


Gln Arg Ser Asn Lys Arg His Leu Cys Pro Val Ala Ser Ile Leu Gly 
                85                  90                  95      


Ser Cys Ser Met Phe Asp Tyr Ile Ser Pro Tyr Ser Phe Glu Asn Ser 
            100                 105                 110         


Ser Ser Gly 
        115 


<210>  1783
<211>  5744
<212>  DNA
<213>  Homosapiens

<400>  1783
agcgcatgga gccagaggag gaggatgaac taggctcagg gcgggatgtg gattccaact     60

ccaacgcgga cagtgagaaa tgggtggcag gagatggttt ggaagaacag gaattttcta    120

tcaaggaggc aaacttcaca gagggaagtc tgaagctaaa gattcagacc acaaagcggg    180

ctaagaaacc cccaaagaat ttggagaact atatatgtcc acctgagatc aagatcacca    240

tcaagcagtc tggggaccag aaggtgtccc gtgctggaaa aaatagcaaa gccacgaagg    300

aggaagaaag aagccactcc aaaaagaagc tcctcacagc cagtgacctt gcagccagtg    360

acctcaaagg atttcagcca caggcttacg aaaggcccca gaaacattca actctccatt    420

atgacacggg cctcccacag gacttcaccg gtgacacctt aaaaccaaag caccagcaaa    480

aaagcagcag ccagaaccac atggactggt ccaccaactc tgacagcgga cccgtcactc    540

agaattgctt catcagtcca gagtctggca gagaaactgc aagcaccagc aagatccccg    600

ctcttgagcc cgtggcttcc tttgcaaagg cccagggtaa gaaaggcagt gcagggaaca    660

cgtggagtca gttgtctaac aataacaaag atctgctctt gggaggtgtg gctccatccc    720

caagcagcca cagctcacca gccccaccca gcagctctgc tgagtgcaac gggcttcagc    780

ccttggtgga tcaagatgga ggaggtacaa aggagccccc agaaccacct acggtgggca    840

gcaagaaaaa gtccagtaaa aaagatgtga taagtcagac cataccaaac ccagacctgg    900

attgggtcaa gaatgcccag aaagcatttg acaatacaga agggaaaagg gaaggttatt    960

ccgcagatag tgcccaagag gcatcaccag ccaggcagaa cgtgagttct gccagtaatc   1020

ctgaaaatga ctcaagtcat gtccggatta ctatccccat caaggcaccc tctctggatc   1080

caaccaacca taagaggaaa aaaagacagt ccattaaagc ggtggtggaa aagatcatgc   1140

cagagaaagc cttggcttct ggaatcacca tgagcagtga agtagttaac aggatacttt   1200

ccaactctga ggggaataag aaggatcccc gtgtccctaa gttgagtaaa atgatagaga   1260

atgagtcccc ctcagttggc cttgaaactg gtggaaatgc tgagaaagtt atcccaggag   1320

gtgtgtctaa gccgcggaag ccacccatgg tcatgacacc tccaacgtgc acagatcact   1380

ctccatccag aaagctgcca gaaatccagc atccaaaatt tgctgcaaaa cgaaggtgga   1440

cttgcagcaa accaaaacct agcaccatgc ttcgagaggc agttatggcc acctctgata   1500

aactgatgct ggagcccccg tctgcatatc ccatcacccc atccagccct ctctacacca   1560

acacagacag tcttactgtg atcactccag tcaaaaagaa gcggggacga ccaaagaagc   1620

agcctttgct cacagtcgag acgattcatg agggaacttc caccagcccc gtcagtccca   1680

tcagccgaga gtttcctggc actaagaaaa gaaagcgacg acgcaattta gcgaagttgg   1740

cccagctagt gccgggagag gacaaaccca tgagcgagat gaaatttcac aagaaagttg   1800

gaaagctcgg cgtgttggat aagaagacca tcaaaactat caataagatg aagacactca   1860

agaggaaaaa catcttgaat cagatcttgt cctgttccag cagcgttgct ctgaaggcaa   1920

aagctccccc agagaccagc cctggggcag cagccattga aagcaaactg ggcaagcaga   1980

ttaatgtcag caagagggga accatctaca ttggcaagaa gcggggcagg aagccaagag   2040

cagagctgcc acccccatcc gaagaaccca aaacagccat caagcacccc aggcctgttt   2100

ctagccagcc ggatgttcca gccgtgcctt ccaactttca gtcacttgtg gcgtcttcac   2160

cagcagctat gcacccactt tcaacacagt taggtgggtc caatggcaac ctgagccctg   2220

ccagcactga aaccaatttt tcagagttga aaactatgcc aaatctccag cccatcagtg   2280

ctcttccaac caaaacccaa aagggaatac acagtggaac ctggaagctg tctccaccca   2340

gactgatggc caactcccct tcacacctgt gcgagattgg ctccctaaag gaaatcacgc   2400

tgtcccctgt gagcgagtcc cacagtgagg agacgatccc cagcgacagc ggcattggga   2460

cagacaacaa cagcacttct gaccaagcgg agaagagctc agaatcccga aggaggtact   2520

cttttgattt ctgctccctg gacaacccgg aggccattcc gtccgacacc agcacaaaga   2580

accggcatgg ccaccggcaa aagcatctca ttgtggacaa ctttctggcc cacgaaagcc   2640

tcaagaagcc aaagcacaag aggaaacgga aaagcctgca aaaccgcgat gacctccagt   2700

ttctggcaga cctggaggag ctaatcacca agttccaagt gttcagaatc tcccaccgga   2760

gttacacctt ctaccacgag aatccatatc ccagcatttt tcggattaat tttgatcact   2820

attacccggt gccatatatc cagtatgacc cgttgctcta tcttcgtagg acttcagact   2880

tgaagtcaaa gaagaagcgt ggtaggcctg caaaaaccaa tgacaccatg acaaaggtgc   2940

cttttttaca agggttcagc taccctattc ccagtggaag ttactatgca ccctatggaa   3000

tgccttacac atcaatgcct atgatgaacc ttggttatta cggtcagtac ccagctcctt   3060

tgtacctatc gcacacgctt ggagcagctt ccccattcat gaggccaaca gtgccaccac   3120

ctcagttcca cacaaactcc cacataaaga tgtccggtgc agctaagcat aaagccaagc   3180

atggagtaca cctgcaggga cctgttagca tgggccttgg tgacatgcag ccttctctga   3240

accctcccaa ggtaggcagt gccagtctgt ccagtggtcg gctccataag aggaaacaca   3300

aacacaagca taagcacaag gaagaccgga tcctagggac ccatgacaac ctgagtggtc   3360

tttttgcagg caaagccaca ggcttctcca gccacatcct gagcgagcgg ctgagtagcg   3420

cagacaaaga gctcccgctg gtgagtgaga agaacaagca taaggagaaa cagaagcacc   3480

agcacagcga agccggccac aaagcttcta agaacaactt tgaggtggac accctgtcta   3540

cactgtcact ttccgacgcc cagcattgga cacaggccaa ggaaaaagga gacttgagca   3600

gtgagcctgt ggactcatgc acgaaaagat actctggcag tggcggggat ggtggcagca   3660

cgagatcgga gaacctggac gtgttcagtg aaatgaaccc ttcgaatgac aagtgggaca   3720

gtgacgtgag tgggagtaaa aggaggagct atgaaggctt tggaacgtac agggaaaagg   3780

acatccaagc cttcaagatg aaccgcaagg agagaagttc ttatgactcc tccatgtctc   3840

cagggatgcc aagtccccac ttaaaagtgg accagacagc agtgcatagt aagaacgaag   3900

gctcagtgcc caccatgatg accaggaaga agccagccgc agttgacagt gttacaattc   3960

caccagcccc agtgttatct ctccttgctg catctgcagc aacgtcggat gcagtcggct   4020

cctccctgaa gaagaggttc aagcggcggg agatcgaagc catccagtgc gaagtgcgga   4080

agatgtgcaa ctacaccaag atcctgtcca ccaagaagaa cctggaccac gtgaacaaga   4140

tcctgaaggc caagcggctg cagagacaat caaaaacagg caacaacttc gtgaagaaga   4200

ggcgcgggcg tcccaggaag cagcccaccc agttcgatga ggactccaga gaccaaatgc   4260

cggtgctgga aaaatgcatc gacctgccca gcaaaagagg ccagaagccc agcctgagcc   4320

cgctggtgct ggagcccgcc gccagccaag acaccatcat ggccaccatc gaggcggtca   4380

tccacatggc ccgggaggcg ccgcccctgc ccccgccacc gccgccgccc ctgccgccac   4440

cgccgccacc acccctgccc ccgccacccc ctctacccaa gaccccccga ggcggaaaga   4500

ggaaacacaa accgcaggcc cccgctcagc ccccacagca gtcgcccccg cagcagcccc   4560

ttccccagga agaggaggtg aaagccaaaa ggcagaggaa gtcccgaggg agtgagagcg   4620

aggtccttcc ctagggcggg tctgggcgtc tgcacctggg gcctagggaa ctgacacgtg   4680

ggaagcgcag tgagccgggg cgggggcgga atcccccgct gcagggacac ccacgccctt   4740

ctctccagaa gccgggcagg cagaatccgg ccagacgacg gggctgagcc atcaggagct   4800

cttgggaaag caaagcaggg agacaccttc agaagaagct tgtctgagct tcaccgcagc   4860

tcccaccacg cggcgcttca gtacggctgg atcctccgca ggcgagcgga aggcccccag   4920

gaggagcagg ctggtggcac tctcctgacc tcacgctgcc aaggtgcgcc ctcgactccc   4980

gatttcattt gctggccagg aaaatcgaaa gggaaacacc ctcaattagg aaacattcca   5040

aggggagaaa agctgcaaat tgctcaactg gcattgctgt aacccgttcc atttaattgg   5100

tttttatttc ttttgatttt caagctctgc taagctttgg ggtaccaacg tcatcttcag   5160

gtgacctgaa tctttccctt aaccgtacag tttctcgatg gaattgtgtg atcagaaggt   5220

ggaattctag tgataggcga cctcagaccc gcattcatgt tctgtgtgcc tcttctattg   5280

cacatacact gatttttagc attgtctatt cctatttttc ctttgcccat tgtacttcca   5340

tatatctttt cattaactta cttgctgcct tttttttttc ttggtacaca tttaaataaa   5400

gtaatcctta acctgtgctg taaagttcac ccttggcatg ctgttccaag aacctgggtt   5460

tgaatcccaa tcgttgtgaa acatactcag tattgataaa acctttttaa taagtgatgc   5520

agagcagcca aggatatgtt gacccagatg tcaaccaggc tatttttata cttaaaacat   5580

gtcagcagag cataggcaga ataaaatggt ttaaataccc cacagcaaat agagtaactg   5640

acaaaccacc aaaaactgaa accccagacc caccagaaag acaagtgtct agcaatgcct   5700

tggtacctga tctttttcat tcaaataatt gtcataggtt gttc                    5744


<210>  1784
<211>  1542
<212>  PRT
<213>  Homosapiens

<400>  1784

Met Glu Pro Glu Glu Glu Asp Glu Leu Gly Ser Gly Arg Asp Val Asp 
1               5                   10                  15      


Ser Asn Ser Asn Ala Asp Ser Glu Lys Trp Val Ala Gly Asp Gly Leu 
            20                  25                  30          


Glu Glu Gln Glu Phe Ser Ile Lys Glu Ala Asn Phe Thr Glu Gly Ser 
        35                  40                  45              


Leu Lys Leu Lys Ile Gln Thr Thr Lys Arg Ala Lys Lys Pro Pro Lys 
    50                  55                  60                  


Asn Leu Glu Asn Tyr Ile Cys Pro Pro Glu Ile Lys Ile Thr Ile Lys 
65                  70                  75                  80  


Gln Ser Gly Asp Gln Lys Val Ser Arg Ala Gly Lys Asn Ser Lys Ala 
                85                  90                  95      


Thr Lys Glu Glu Glu Arg Ser His Ser Lys Lys Lys Leu Leu Thr Ala 
            100                 105                 110         


Ser Asp Leu Ala Ala Ser Asp Leu Lys Gly Phe Gln Pro Gln Ala Tyr 
        115                 120                 125             


Glu Arg Pro Gln Lys His Ser Thr Leu His Tyr Asp Thr Gly Leu Pro 
    130                 135                 140                 


Gln Asp Phe Thr Gly Asp Thr Leu Lys Pro Lys His Gln Gln Lys Ser 
145                 150                 155                 160 


Ser Ser Gln Asn His Met Asp Trp Ser Thr Asn Ser Asp Ser Gly Pro 
                165                 170                 175     


Val Thr Gln Asn Cys Phe Ile Ser Pro Glu Ser Gly Arg Glu Thr Ala 
            180                 185                 190         


Ser Thr Ser Lys Ile Pro Ala Leu Glu Pro Val Ala Ser Phe Ala Lys 
        195                 200                 205             


Ala Gln Gly Lys Lys Gly Ser Ala Gly Asn Thr Trp Ser Gln Leu Ser 
    210                 215                 220                 


Asn Asn Asn Lys Asp Leu Leu Leu Gly Gly Val Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser His Ser Ser Pro Ala Pro Pro Ser Ser Ser Ala Glu Cys Asn Gly 
                245                 250                 255     


Leu Gln Pro Leu Val Asp Gln Asp Gly Gly Gly Thr Lys Glu Pro Pro 
            260                 265                 270         


Glu Pro Pro Thr Val Gly Ser Lys Lys Lys Ser Ser Lys Lys Asp Val 
        275                 280                 285             


Ile Ser Gln Thr Ile Pro Asn Pro Asp Leu Asp Trp Val Lys Asn Ala 
    290                 295                 300                 


Gln Lys Ala Phe Asp Asn Thr Glu Gly Lys Arg Glu Gly Tyr Ser Ala 
305                 310                 315                 320 


Asp Ser Ala Gln Glu Ala Ser Pro Ala Arg Gln Asn Val Ser Ser Ala 
                325                 330                 335     


Ser Asn Pro Glu Asn Asp Ser Ser His Val Arg Ile Thr Ile Pro Ile 
            340                 345                 350         


Lys Ala Pro Ser Leu Asp Pro Thr Asn His Lys Arg Lys Lys Arg Gln 
        355                 360                 365             


Ser Ile Lys Ala Val Val Glu Lys Ile Met Pro Glu Lys Ala Leu Ala 
    370                 375                 380                 


Ser Gly Ile Thr Met Ser Ser Glu Val Val Asn Arg Ile Leu Ser Asn 
385                 390                 395                 400 


Ser Glu Gly Asn Lys Lys Asp Pro Arg Val Pro Lys Leu Ser Lys Met 
                405                 410                 415     


Ile Glu Asn Glu Ser Pro Ser Val Gly Leu Glu Thr Gly Gly Asn Ala 
            420                 425                 430         


Glu Lys Val Ile Pro Gly Gly Val Ser Lys Pro Arg Lys Pro Pro Met 
        435                 440                 445             


Val Met Thr Pro Pro Thr Cys Thr Asp His Ser Pro Ser Arg Lys Leu 
    450                 455                 460                 


Pro Glu Ile Gln His Pro Lys Phe Ala Ala Lys Arg Arg Trp Thr Cys 
465                 470                 475                 480 


Ser Lys Pro Lys Pro Ser Thr Met Leu Arg Glu Ala Val Met Ala Thr 
                485                 490                 495     


Ser Asp Lys Leu Met Leu Glu Pro Pro Ser Ala Tyr Pro Ile Thr Pro 
            500                 505                 510         


Ser Ser Pro Leu Tyr Thr Asn Thr Asp Ser Leu Thr Val Ile Thr Pro 
        515                 520                 525             


Val Lys Lys Lys Arg Gly Arg Pro Lys Lys Gln Pro Leu Leu Thr Val 
    530                 535                 540                 


Glu Thr Ile His Glu Gly Thr Ser Thr Ser Pro Val Ser Pro Ile Ser 
545                 550                 555                 560 


Arg Glu Phe Pro Gly Thr Lys Lys Arg Lys Arg Arg Arg Asn Leu Ala 
                565                 570                 575     


Lys Leu Ala Gln Leu Val Pro Gly Glu Asp Lys Pro Met Ser Glu Met 
            580                 585                 590         


Lys Phe His Lys Lys Val Gly Lys Leu Gly Val Leu Asp Lys Lys Thr 
        595                 600                 605             


Ile Lys Thr Ile Asn Lys Met Lys Thr Leu Lys Arg Lys Asn Ile Leu 
    610                 615                 620                 


Asn Gln Ile Leu Ser Cys Ser Ser Ser Val Ala Leu Lys Ala Lys Ala 
625                 630                 635                 640 


Pro Pro Glu Thr Ser Pro Gly Ala Ala Ala Ile Glu Ser Lys Leu Gly 
                645                 650                 655     


Lys Gln Ile Asn Val Ser Lys Arg Gly Thr Ile Tyr Ile Gly Lys Lys 
            660                 665                 670         


Arg Gly Arg Lys Pro Arg Ala Glu Leu Pro Pro Pro Ser Glu Glu Pro 
        675                 680                 685             


Lys Thr Ala Ile Lys His Pro Arg Pro Val Ser Ser Gln Pro Asp Val 
    690                 695                 700                 


Pro Ala Val Pro Ser Asn Phe Gln Ser Leu Val Ala Ser Ser Pro Ala 
705                 710                 715                 720 


Ala Met His Pro Leu Ser Thr Gln Leu Gly Gly Ser Asn Gly Asn Leu 
                725                 730                 735     


Ser Pro Ala Ser Thr Glu Thr Asn Phe Ser Glu Leu Lys Thr Met Pro 
            740                 745                 750         


Asn Leu Gln Pro Ile Ser Ala Leu Pro Thr Lys Thr Gln Lys Gly Ile 
        755                 760                 765             


His Ser Gly Thr Trp Lys Leu Ser Pro Pro Arg Leu Met Ala Asn Ser 
    770                 775                 780                 


Pro Ser His Leu Cys Glu Ile Gly Ser Leu Lys Glu Ile Thr Leu Ser 
785                 790                 795                 800 


Pro Val Ser Glu Ser His Ser Glu Glu Thr Ile Pro Ser Asp Ser Gly 
                805                 810                 815     


Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp Gln Ala Glu Lys Ser Ser 
            820                 825                 830         


Glu Ser Arg Arg Arg Tyr Ser Phe Asp Phe Cys Ser Leu Asp Asn Pro 
        835                 840                 845             


Glu Ala Ile Pro Ser Asp Thr Ser Thr Lys Asn Arg His Gly His Arg 
    850                 855                 860                 


Gln Lys His Leu Ile Val Asp Asn Phe Leu Ala His Glu Ser Leu Lys 
865                 870                 875                 880 


Lys Pro Lys His Lys Arg Lys Arg Lys Ser Leu Gln Asn Arg Asp Asp 
                885                 890                 895     


Leu Gln Phe Leu Ala Asp Leu Glu Glu Leu Ile Thr Lys Phe Gln Val 
            900                 905                 910         


Phe Arg Ile Ser His Arg Ser Tyr Thr Phe Tyr His Glu Asn Pro Tyr 
        915                 920                 925             


Pro Ser Ile Phe Arg Ile Asn Phe Asp His Tyr Tyr Pro Val Pro Tyr 
    930                 935                 940                 


Ile Gln Tyr Asp Pro Leu Leu Tyr Leu Arg Arg Thr Ser Asp Leu Lys 
945                 950                 955                 960 


Ser Lys Lys Lys Arg Gly Arg Pro Ala Lys Thr Asn Asp Thr Met Thr 
                965                 970                 975     


Lys Val Pro Phe Leu Gln Gly Phe Ser Tyr Pro Ile Pro Ser Gly Ser 
            980                 985                 990         


Tyr Tyr Ala Pro Tyr Gly Met Pro  Tyr Thr Ser Met Pro  Met Met Asn 
        995                 1000                 1005             


Leu Gly  Tyr Tyr Gly Gln Tyr  Pro Ala Pro Leu Tyr  Leu Ser His 
    1010                 1015                 1020             


Thr Leu  Gly Ala Ala Ser Pro  Phe Met Arg Pro Thr  Val Pro Pro 
    1025                 1030                 1035             


Pro Gln  Phe His Thr Asn Ser  His Ile Lys Met Ser  Gly Ala Ala 
    1040                 1045                 1050             


Lys His  Lys Ala Lys His Gly  Val His Leu Gln Gly  Pro Val Ser 
    1055                 1060                 1065             


Met Gly  Leu Gly Asp Met Gln  Pro Ser Leu Asn Pro  Pro Lys Val 
    1070                 1075                 1080             


Gly Ser  Ala Ser Leu Ser Ser  Gly Arg Leu His Lys  Arg Lys His 
    1085                 1090                 1095             


Lys His  Lys His Lys His Lys  Glu Asp Arg Ile Leu  Gly Thr His 
    1100                 1105                 1110             


Asp Asn  Leu Ser Gly Leu Phe  Ala Gly Lys Ala Thr  Gly Phe Ser 
    1115                 1120                 1125             


Ser His  Ile Leu Ser Glu Arg  Leu Ser Ser Ala Asp  Lys Glu Leu 
    1130                 1135                 1140             


Pro Leu  Val Ser Glu Lys Asn  Lys His Lys Glu Lys  Gln Lys His 
    1145                 1150                 1155             


Gln His  Ser Glu Ala Gly His  Lys Ala Ser Lys Asn  Asn Phe Glu 
    1160                 1165                 1170             


Val Asp  Thr Leu Ser Thr Leu  Ser Leu Ser Asp Ala  Gln His Trp 
    1175                 1180                 1185             


Thr Gln  Ala Lys Glu Lys Gly  Asp Leu Ser Ser Glu  Pro Val Asp 
    1190                 1195                 1200             


Ser Cys  Thr Lys Arg Tyr Ser  Gly Ser Gly Gly Asp  Gly Gly Ser 
    1205                 1210                 1215             


Thr Arg  Ser Glu Asn Leu Asp  Val Phe Ser Glu Met  Asn Pro Ser 
    1220                 1225                 1230             


Asn Asp  Lys Trp Asp Ser Asp  Val Ser Gly Ser Lys  Arg Arg Ser 
    1235                 1240                 1245             


Tyr Glu  Gly Phe Gly Thr Tyr  Arg Glu Lys Asp Ile  Gln Ala Phe 
    1250                 1255                 1260             


Lys Met  Asn Arg Lys Glu Arg  Ser Ser Tyr Asp Ser  Ser Met Ser 
    1265                 1270                 1275             


Pro Gly  Met Pro Ser Pro His  Leu Lys Val Asp Gln  Thr Ala Val 
    1280                 1285                 1290             


His Ser  Lys Asn Glu Gly Ser  Val Pro Thr Met Met  Thr Arg Lys 
    1295                 1300                 1305             


Lys Pro  Ala Ala Val Asp Ser  Val Thr Ile Pro Pro  Ala Pro Val 
    1310                 1315                 1320             


Leu Ser  Leu Leu Ala Ala Ser  Ala Ala Thr Ser Asp  Ala Val Gly 
    1325                 1330                 1335             


Ser Ser  Leu Lys Lys Arg Phe  Lys Arg Arg Glu Ile  Glu Ala Ile 
    1340                 1345                 1350             


Gln Cys  Glu Val Arg Lys Met  Cys Asn Tyr Thr Lys  Ile Leu Ser 
    1355                 1360                 1365             


Thr Lys  Lys Asn Leu Asp His  Val Asn Lys Ile Leu  Lys Ala Lys 
    1370                 1375                 1380             


Arg Leu  Gln Arg Gln Ser Lys  Thr Gly Asn Asn Phe  Val Lys Lys 
    1385                 1390                 1395             


Arg Arg  Gly Arg Pro Arg Lys  Gln Pro Thr Gln Phe  Asp Glu Asp 
    1400                 1405                 1410             


Ser Arg  Asp Gln Met Pro Val  Leu Glu Lys Cys Ile  Asp Leu Pro 
    1415                 1420                 1425             


Ser Lys  Arg Gly Gln Lys Pro  Ser Leu Ser Pro Leu  Val Leu Glu 
    1430                 1435                 1440             


Pro Ala  Ala Ser Gln Asp Thr  Ile Met Ala Thr Ile  Glu Ala Val 
    1445                 1450                 1455             


Ile His  Met Ala Arg Glu Ala  Pro Pro Leu Pro Pro  Pro Pro Pro 
    1460                 1465                 1470             


Pro Pro  Leu Pro Pro Pro Pro  Pro Pro Pro Leu Pro  Pro Pro Pro 
    1475                 1480                 1485             


Pro Leu  Pro Lys Thr Pro Arg  Gly Gly Lys Arg Lys  His Lys Pro 
    1490                 1495                 1500             


Gln Ala  Pro Ala Gln Pro Pro  Gln Gln Ser Pro Pro  Gln Gln Pro 
    1505                 1510                 1515             


Leu Pro  Gln Glu Glu Glu Val  Lys Ala Lys Arg Gln  Arg Lys Ser 
    1520                 1525                 1530             


Arg Gly  Ser Glu Ser Glu Val  Leu Pro 
    1535                 1540         


<210>  1785
<211>  5050
<212>  DNA
<213>  Homosapiens

<400>  1785
agaagaaggg gagaggaggt tgtgtgggac aaggtgctcc tgacagaagg atgccacagc     60

tgagcctgtc ctcgctgggc ctttggccaa tggcagcatc cccgtggctg ctcctgctgc    120

tggttggggc ctcctggctc ctggcccgca tcctggcctg gacctatacc ttctatgaca    180

actgctgccg cctccggtgt ttcccgcaac ccccgaaacg gaattggttc ttgggtcacc    240

tgggcctgat tcacagctcg gaggaaggtc tcctatacac acaaagcctg gcatgcacct    300

tcggtgatat gtgctgctgg tgggtggggc cctggcacgc aatcgtccgc atcttccacc    360

ccacctacat caagcctgtg ctctttgctc cagctgccat tgtaccaaag gacaaggtct    420

tctacagctt cctgaagccc tggctggggg atgggctcct gctgagtgct ggtgaaaagt    480

ggagccgcca ccgtcggatg ctgacgcctg ccttccattt caacatcctg aagccctata    540

tgaagatttt caatgagagt gtgaacatca tgcatgccaa gtggcagctc ctggcctcag    600

agggtagtgc ccgtctggac atgtttgagc acatcagcct catgaccttg gacagtctgc    660

agaaatgtgt cttcagcttt gacagccatt gccaggagaa gcccagtgaa tatattgccg    720

ccatcttgga gctcagtgcc cttgtgacaa aaagacacca gcagatcctc ctgtacatag    780

acttcctgta ttatctcacc cctgatgggc agcgtttccg cagggcctgc cgcctggtgc    840

acgacttcac agatgacgtc atccaggagc ggcgccgcac cctccctagc cagggtgttg    900

atgacttcct ccaagccaag gccaaatcca agactttgga cttcattgat gtactcctgc    960

tgagcaagga tgaagatggg aagaagttgt ccgatgagga cataagagca gaagctgaca   1020

cctttatgtt tgagggccat gacaccacag ccagtggtct ctcctgggtc ctgtaccacc   1080

ttgcaaagca cccggaatac caggagcgct gtcggcagga ggtacaagag cttctgaagg   1140

accgtgagcc taaagagatt gaatgggacg acctggccca gctgcccttc ctgaccatgt   1200

gcattaagga gagcctgagg ctgcatcccc cagtccctgc cgtctctcgc tgctgcaccc   1260

aagacattgt gctcccagac ggccgggtca tccccaaagg cattatctgc ctcatcagtg   1320

tttttggaac ccatcacaac ccagccgtgt ggccggaccc tgaggtctat gacccctttc   1380

gctttgaccc aaagaacatc aaggagaggt cacctctggc ttttattccc ttctcagcag   1440

ggcccaggaa ctgcatcggg caggcgttcg cgatggcgga gatgaaggtg gtcctggggc   1500

tcacgctgct ggccttccgc gtcctgcctg accacaccga gccccgcagg aagccggagc   1560

tggtcctgcg cgcagagggc ggactttggc tgcgggtgga gcccctgagc tgagttctgc   1620

agagacccac tctgacccca ctaaaatgac ccctgattca tcaaaagtga ggcctagaat   1680

taccctaaga ccctgttcca cagtcctgta ttccatccta gatatctact caaaataatt   1740

gagacaagtg ttcaaacaga aagacgcttg tgcggaatgt tcatggcagc cctattcaca   1800

gtagcccaaa cgatgaaaac accccaagct atatattacc agataaaagg ataaacacaa   1860

tatggtccat ccatacactg gagtattaca cagccataaa aaggaatgaa gcagtgatcc   1920

ccactacact gtggatgaac cttgaatgca tgatactgaa tgaaagacat cagatgcaaa   1980

aggtcacata gtgtactgtc cttttatatg gaaatttcca gaacaggcca atctgaagag   2040

atgtatagtg gattggtggc tttcagcagc tgtggggagg tgggactgag gagcgactgc   2100

taatcaggat ggggttttct cctgggatgg tgaaaatgtt ccggacctag atagtgatga   2160

aggtagcacg acactgtgag tgcactaaat gctattgaat tagacacttt agaatggttg   2220

aaatagtgat ttttatgtga attctaccta aacatgctat tacagctcat atatactttt   2280

tccatctgga ttcttcacaa aagaatatgt tgtgagcatc tttccatgat attaaatcat   2340

cttaggaaac attattttgt gttcttcaaa atgtgcatgt taagtattca aatcagtctt   2400

aaatttttaa aaatatgtaa ttttagaaaa taatttaaaa ggttttgttt cagtttgtaa   2460

gatttctttt ctggcacttt aatggcttga ggtatcatta tcagttacaa attgagttat   2520

tcttcatcaa atgacttttg gagtagagat tttattttta tagcaataga tgcacagata   2580

ttcctgtaag atacaggtgt ggttagacac ttttctagaa caggcatgcc ctgcaaactc   2640

cacagacact gactgttttt gtcctatgaa caagcagacc actgagaagg gagaaggtga   2700

cattttagct ttcccaggta aaagtggttt tcatcctcac accaatttta tggactggac   2760

gttaactctc ttgctcaagg tcactctgtg agtggaagag tggggataaa tctggttcgt   2820

ttggcatcag aggccatgac ttttcctacc acagaagtaa ttttcaaagt aagtctctgc   2880

cctaggcaca tcagatcacc tggggaccac tccagagtga gtagacaaga ctttgacagg   2940

ggtgcctaat tttttttttt ttttttgaga tggagtctcg ctctgttgcc caggctggag   3000

tgcggtggca tgatctcggt tcattgcaac ctccgcctcc tgcgttcggg tgattgacct   3060

gtctcggcct cccgggtggc tgggattgca ggcacccacc accacgtcca gctaattgtt   3120

gtatttttga tagaggcggg gtttcgccat gttacactgg ctggtgttga actcctaacc   3180

tcaggtgatc cacctgcctc ggcctcccaa agtgctggga ttacaggcct ggccccagtt   3240

tgatagtttg ttatcatgtt atacgtacac ttagaataat gatccagcca tctcattcta   3300

acagcaatga gaacttaggc tcccctctct actaaagtac aaaagttagc tggtcgtggt   3360

ggtgcgggcc tgtggtccca gctgctcggg aggttgatgc aggagaatca cttgaaaccc   3420

acaggcggag gttgcggtgg gctggggtgg tgccactgcg ctccagcctg ggggaggggg   3480

acatagcgag actcggtctc aaaaacaaaa caaaacaaaa caaaacaaaa caaaacaaaa   3540

caaaacaaaa cactgccaaa ctgtttccaa agcatctgca tcgtgtttaa tttccataag   3600

taacgtatga gaattctagg tcctccaaat aattagcagt ccttcgtagg gtcagttttt   3660

gtttcagcct tccttatggg tatgctgtgg catatccctg agattttaat tcgcattttc   3720

cagtgactaa gggtgttgaa ccactcgtgc cttcctgtgc ctatttgaca ctcctatatt   3780

ttctttggag aagagtctgt tcaatcatct gctcattaaa ttttccttcg attgtttgcc   3840

ttcttattgt tggattttga gagttctatg tacaagtcct ttgtcagtcg tgtgatttgc   3900

aagtcttctt cctagactct gaagtttctt tctttcatag agcaaatgtt ttaaattttt   3960

atgaggtaag acttctcagc attatttttg gtgaattatg tttatactgc catatatagg   4020

aactctttgc ttaactggag gtcatggaga ttttctccta cattttcttt taaaagtttt   4080

atagtttcag agtttacatg taattccata atctccattt agttaaattt tgtgtggggt   4140

gtgaactgtg gtttaactgt tttcttgtat atggatatcc aattgtttca cacaattttt   4200

ttgaaaagaa tatccttggc agggcacggt agctcacacc tgtaatccca gcactttagg   4260

aggtcaaggt gggcagatca tgaggtcagg agtttgagac cagcctggcc aatatggtga   4320

aaccacgtct ctattaaaaa tagaaaaatt agccaggcgt ggtggtgtgt gcctgtattc   4380

acagctgctt ggatggctga ggcaggagaa tcgcttgaac ccaggagtca gaggtttcag   4440

tgagccgaga ttgtgccact gcactccagc ctgggtgaaa gagctagatt ctctctctca   4500

aaaaaaaaaa aaaaaaggaa agaaagaaag aaaagaaaag aaaatccctt tttgctttaa   4560

cttgcccttg caggtttgta gaaactcaat tgttgaaatt tgggtggata aatttctgga   4620

ttttctatct attccatgtt ggaccaatac cacactgccc tagtcactgt tgcattatag   4680

tatatcttta aaggagtaat gggaatcctt caactacatt tttttcccca ataatttttg   4740

gctattctgc ttcttttgtg tttctatgta aattttatca tcagtgtgtc tatttctaca   4800

aatagtcctg atagggtttg aattgggatt tctgtgaatc tatagatcaa tctgaggaga   4860

cttaataatg atattgattc tcccaattca tgaatatagt atacccctgt atttatttgt   4920

tttcttgaat ttcttttatc attgttttgt agttttcacc atgacagtct tgcacatatt   4980

ttgttaaatg tacagctgag aatttaattt tttctggtgt acaatgctaa taaaatggtg   5040

actttaaaag                                                          5050


<210>  1786
<211>  520
<212>  PRT
<213>  Homosapiens

<400>  1786

Met Pro Gln Leu Ser Leu Ser Ser Leu Gly Leu Trp Pro Met Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Cys Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Ile His Ser Ser Glu Glu Gly Leu Leu Tyr Thr Gln Ser Leu 
65                  70                  75                  80  


Ala Cys Thr Phe Gly Asp Met Cys Cys Trp Trp Val Gly Pro Trp His 
                85                  90                  95      


Ala Ile Val Arg Ile Phe His Pro Thr Tyr Ile Lys Pro Val Leu Phe 
            100                 105                 110         


Ala Pro Ala Ala Ile Val Pro Lys Asp Lys Val Phe Tyr Ser Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Glu Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Thr Lys Arg His Gln Gln Ile Leu 
225                 230                 235                 240 


Leu Tyr Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Asp Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Ala Val Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Lys 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Gly Leu Thr Leu Leu Ala Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  1787
<211>  1694
<212>  DNA
<213>  Homosapiens

<400>  1787
cgtgtgggac aagctgctcc cgacagaagg atgtcgctgc tgagcctgcc ctggctgggc     60

ctcagactgg tggcaatgtc cccatggcta ctcctgctgc tggttgtggg ctcctggcta    120

ctcgcccgca tcctggcttg gacctatgcc ttctataaca actgccgccg gctccagtgt    180

ttcccacagc ccccaaaacg gaactggttt tggggtcacc tgggcctgat cactcctaca    240

gaggagggct tgaaggactc gacccagatg tcggccacct attcccaggg ctttacggta    300

tggctgggtc ccatcatccc cttcatcgtt ttatgccacc ctgacaccat ccggtctatc    360

accaatgcct cagctgccat tgcacccaag gataatctct tcatcaggtt cctgaagccc    420

tggctgggag aagggatact gctgagtggc ggtgacaagt ggagccgcca ccgtcggatg    480

ctgacgcccg ccttccattt caacatcctg aagtcctata taacgatctt caacaagagt    540

gcaaacatca tgcttgacaa gtggcagcac ctggcctcag agggcagcag tcgtctggac    600

atgtttgagc acatcagcct catgaccttg gacagtctac agaaatgcat cttcagcttt    660

gacagccatt gtcaggagag gcccagtgaa tatattgcca ccatcttgga gctcagtgcc    720

cttgtagaga aaagaagcca gcatatcctc cagcacatgg actttctgta ttacctctcc    780

catgacgggc ggcgcttcca cagggcctgc cgcctggtgc atgacttcac agacgctgtc    840

atccgggagc ggcgtcgcac cctccccact cagggtattg atgatttttt caaagacaaa    900

gccaagtcca agactttgga tttcattgat gtgcttctgc tgagcaagga tgaagatggg    960

aaggcattgt cagatgagga tataagagca gaggctgaca ccttcatgtt tggaggccat   1020

gacaccacgg ccagtggcct ctcctgggtc ctgtacaacc ttgcgaggca cccagaatac   1080

caggagcgct gccgacagga ggtgcaagag cttctgaagg accgcgatcc taaagagatt   1140

gaatgggacg acctggccca gctgcccttc ctgaccatgt gcgtgaagga gagcctgagg   1200

ttacatcccc cagctccctt catctcccga tgctgcaccc aggacattgt tctcccagat   1260

ggccgagtca tccccaaagg cattacctgc ctcatcgata ttataggggt ccatcacaac   1320

ccaactgtgt ggccggatcc tgaggtctac gaccccttcc gctttgaccc agagaacagc   1380

aaggggaggt cacctctggc ttttattcct ttctccgcag ggcccaggaa ctgcatcggg   1440

caggcgttcg ccatggcgga gatgaaagtg gtcctggcgt tgatgctgct gcacttccgg   1500

ttcctgccag accacactga gccccgcagg aagctggaat tgatcatgcg cgccgagggc   1560

gggctttggc tgcgggtgga gcccctgaat gtaggcttgc agtgactttc tgacccatcc   1620

acctgttttt ttgcagattg tcatgaataa aacggtgctg tcacctctgc ctgggcctca   1680

ctgacagcct gcag                                                     1694


<210>  1788
<211>  524
<212>  PRT
<213>  Homosapiens

<400>  1788

Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Leu Val Ala Met 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu 
    50                  55                  60                  


Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asp Ser Thr Gln Met 
65                  70                  75                  80  


Ser Ala Thr Tyr Ser Gln Gly Phe Thr Val Trp Leu Gly Pro Ile Ile 
                85                  90                  95      


Pro Phe Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Ser Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp 
                165                 170                 175     


Lys Trp Gln His Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu 
225                 230                 235                 240 


Gln His Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys 
        275                 280                 285             


Asp Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Val Lys Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ser Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Asn Val Gly Leu Gln 
        515                 520                 


<210>  1789
<211>  948
<212>  DNA
<213>  Homosapiens

<400>  1789
atgctggggc taaaccacac ctccatgtct gaattcatcc tcgtcggctt ctctgccttc     60

ccccacctcc aactgatgct cttcctgctg ttcctgctga tgtacctgtt cacgctgctg    120

ggcaacctgc tcatcatggc caccgtctgg agcgagcgca gcctccacac gcccatgtac    180

ctcttcctgt gcgtcctctc agtctccgag atcctctaca ccgtggccat catcccgcgc    240

atgctggccg acctgctgtc cacccagcgc tccatcgcct tcctggcctg tgccagtcag    300

atgttcttct ccttcagctt cggcttcacc cactccttcc tgctcaccgt catgggctac    360

gaccgctacg tggccatctg ccaccccctg cgctacaacg tgctcatgag cccacggggc    420

tgcgcctgcc tggtgggctg ctcctgggct ggtggctcgg tcatggggat ggtggtgacc    480

tcggccattt tccaactgac tttctgtgga tcccatgaga tccagcattt tttatgtcat    540

gtgccacctc tgttgaagtt ggcctgtgga aataatgtac cagctgtggc cctgggcgtg    600

ggcttggtat gtatcatggc actgctgggc tgttttctcc tcatcctcct ctcctatgcc    660

ttcatcgtgg ccgacatctt gaagatccct tctgctgaag gtcggaacaa ggccttctcc    720

acctgtgcct ctcaccttat tgtggtcatt gtgcactatg gctttgcctc tgtcatctac    780

ctcaagccca aaggtcccca ctctcaggag ggtgacaccc tgatggccac cacctacgca    840

gtcctcacgc ccttcctcag ccccatcatc ttcagcctca ggaacaaaga actgaaggtt    900

gccatgaaga ggaccttcct cagcacactc tattcctcag gcacctga                 948


<210>  1790
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  1790

Met Leu Gly Leu Asn His Thr Ser Met Ser Glu Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 
        35                  40                  45              


Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Cys 
    50                  55                  60                  


Val Leu Ser Val Ser Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 
65                  70                  75                  80  


Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 
                85                  90                  95      


Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 
            100                 105                 110         


Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Cys Leu 
    130                 135                 140                 


Val Gly Cys Ser Trp Ala Gly Gly Ser Val Met Gly Met Val Val Thr 
145                 150                 155                 160 


Ser Ala Ile Phe Gln Leu Thr Phe Cys Gly Ser His Glu Ile Gln His 
                165                 170                 175     


Phe Leu Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asn Asn 
            180                 185                 190         


Val Pro Ala Val Ala Leu Gly Val Gly Leu Val Cys Ile Met Ala Leu 
        195                 200                 205             


Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 
    210                 215                 220                 


Asp Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ala Ser His Leu Ile Val Val Ile Val His Tyr Gly Phe Ala 
                245                 250                 255     


Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro His Ser Gln Glu Gly Asp 
            260                 265                 270         


Thr Leu Met Ala Thr Thr Tyr Ala Val Leu Thr Pro Phe Leu Ser Pro 
        275                 280                 285             


Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Arg 
    290                 295                 300                 


Thr Phe Leu Ser Thr Leu Tyr Ser Ser Gly Thr 
305                 310                 315 


<210>  1791
<211>  951
<212>  DNA
<213>  Homosapiens

<400>  1791
atgcctggtc agaactacag aaccatatct gaatttatcc tctctggctt ctcagccttc     60

ccccagcagc tcctgcctgt cttgttcctg ctgtacctcc tgatgttcct gttcacattg    120

cttggcaacc ttcttatcat ggccacagtt tggattgaac gcagactcca cacacccatg    180

tacctcttct tgtgtgccct ctccatctct gagattctgt tcactgttgc catcacccct    240

cgcatgctgg ctgatctgct cttcacccat cgttccatca cctttgtggc ttgtgccatt    300

cagatgttct tctccttcat gtttggcttc actcactcct tccttctcat ggtcatgggc    360

tatgatcact acgtgaccat ctgccaccca ctgcattaca acatgctaat gagtccccgt    420

ggctgtgccc atcttgtggc ctggacctgg gctggtggct cggtcatggg gatgatggtg    480

acaatgatgg tttttcacct cactttctgt gggtctaatg tgatccacca ttttctctgt    540

catgtgcttt ccctcttgaa gttggcctgt gggagcaaga catcatctgt catcatgggt    600

gtgatgctgg tgtgtgtcac agccctgata ggctgtttgt tcctcatcat cctctccttt    660

gtcttcattg tggctgccat cttgaggatt ccttctgctg agggccggca caagactttc    720

tccacttgtg tatcccacct cactgtggtg gtcatgcact atagttttgc ctcccttatc    780

tacctcaaac ccaagggcct ccattctatg tacagtgatg ccttgatggc caccacctat    840

actgtcttca cccccttcct cagcccaatc attttcagtc taaggaacaa ggagctgaag    900

aatgccataa ataaaaactt ttgcagaagg ttctgccctc taagctccta a             951


<210>  1792
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  1792

Met Pro Gly Gln Asn Tyr Arg Thr Ile Ser Glu Phe Ile Leu Ser Gly 
1               5                   10                  15      


Phe Ser Ala Phe Pro Gln Gln Leu Leu Pro Val Leu Phe Leu Leu Tyr 
            20                  25                  30          


Leu Leu Met Phe Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala 
        35                  40                  45              


Thr Val Trp Ile Glu Arg Arg Leu His Thr Pro Met Tyr Leu Phe Leu 
    50                  55                  60                  


Cys Ala Leu Ser Ile Ser Glu Ile Leu Phe Thr Val Ala Ile Thr Pro 
65                  70                  75                  80  


Arg Met Leu Ala Asp Leu Leu Phe Thr His Arg Ser Ile Thr Phe Val 
                85                  90                  95      


Ala Cys Ala Ile Gln Met Phe Phe Ser Phe Met Phe Gly Phe Thr His 
            100                 105                 110         


Ser Phe Leu Leu Met Val Met Gly Tyr Asp His Tyr Val Thr Ile Cys 
        115                 120                 125             


His Pro Leu His Tyr Asn Met Leu Met Ser Pro Arg Gly Cys Ala His 
    130                 135                 140                 


Leu Val Ala Trp Thr Trp Ala Gly Gly Ser Val Met Gly Met Met Val 
145                 150                 155                 160 


Thr Met Met Val Phe His Leu Thr Phe Cys Gly Ser Asn Val Ile His 
                165                 170                 175     


His Phe Leu Cys His Val Leu Ser Leu Leu Lys Leu Ala Cys Gly Ser 
            180                 185                 190         


Lys Thr Ser Ser Val Ile Met Gly Val Met Leu Val Cys Val Thr Ala 
        195                 200                 205             


Leu Ile Gly Cys Leu Phe Leu Ile Ile Leu Ser Phe Val Phe Ile Val 
    210                 215                 220                 


Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe 
225                 230                 235                 240 


Ser Thr Cys Val Ser His Leu Thr Val Val Val Met His Tyr Ser Phe 
                245                 250                 255     


Ala Ser Leu Ile Tyr Leu Lys Pro Lys Gly Leu His Ser Met Tyr Ser 
            260                 265                 270         


Asp Ala Leu Met Ala Thr Thr Tyr Thr Val Phe Thr Pro Phe Leu Ser 
        275                 280                 285             


Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Asn 
    290                 295                 300                 


Lys Asn Phe Cys Arg Arg Phe Cys Pro Leu Ser Ser 
305                 310                 315     


<210>  1793
<211>  1587
<212>  DNA
<213>  Homosapiens

<400>  1793
atgccgcagc tgagcctgtc ctggctgggc ctcgggcagg tggcagcatt cccgtggctg     60

ctcctgctgc tggctggggc ctcccggctc ctggccggct tcctggcctg gacctatgcc    120

ttctatgaca actgccgccg ccttcagtac tttccacaac ccccaaaaca gaaatggttt    180

tggggtcaac caggacctca ggaaggcttg aagaacttga cccagatgtc agccacctat    240

ccccagggct ttaggatatg gctgggtccc atcttcccct tcatcgtttt atgccaccct    300

gacatcgtcc ggtctatcac caatgcctca gctgctattg cgcccaagga tgatctctcc    360

atcaggttcc tgaagccctg gctgggagaa gggatactgc tgagtggcgg tgacaagtgg    420

agccgccacc gtcggatgct gacgcccgcc ttccatttca acatcctgaa accctatata    480

aagatcttca acaggagtgt gaacatcatg cacgacaagt ggcagcacct ggcctcagag    540

ggcagcagtc gtctggacat gtttgagcac atcagcctca tgaccttgga cagtctgcag    600

aaatgcatct tcagctttga cagccattgt caggagaggc ccagtgaata tattgctacc    660

atcttggagc tcagtgccct tgtagaaaaa agaaaccagc atatcctcca gcacatggac    720

tttctgtatt acctctccca tgacgggtgg cgcttccgca gggcctgccg cctggtgcac    780

gacttcacag atgccgtcat ccaggagcgg cgccataccc ttcccactca gggtattgat    840

gaagatggga aggtgttgtc agatgaggat gtaagagcag aggctgacac cttcatgttt    900

gcaggccatg acaccacagc cagtggtctc tcctgggtcc tgtacaacct cgcgaggcac    960

ccagaatacc aggagcactg ccggcaggag gtgcaagagc ttctgaagga ccgcgatcct   1020

aaagagattg aatggtacga cctggcccag ctgcccttcc tgaccatgtg cgtgaaggag   1080

agcctgcggt tgcatccccc tgttccgtac acctcccgcc accgcatctg ggacattgtg   1140

ctcccagatg gcattatctg catcatcaac attataggaa tccatcacaa cccaactgtc   1200

tacaacccct tccgcttcaa ctcagagaac agcaaggaga ggtcacctct ggcttttatt   1260

cccttctctg cgggacccag tttatgggaa aatgtccata gaatgggggc tgatctgggt   1320

gcggttgagg atcccgggcc aggtttccgg cgtgatgggg cccaaatgcg gatcctgggc   1380

gcagtcacag tccccactcc cacccgcagg aactgcatcg ggcaggcgtt cgccatggcg   1440

aagatgaagg tggtcctggc gctgacgctg ctgcgcttcc gcttcctgct ggaccacacg   1500

gagccccgca ggaagccgga gctgatcatg cgcgctgaag gaggactttg gctgcgagtg   1560

gagcccctga acgcgggctt gcagtga                                       1587


<210>  1794
<211>  528
<212>  PRT
<213>  Homosapiens

<400>  1794

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Gln Val Ala Ala 
1               5                   10                  15      


Phe Pro Trp Leu Leu Leu Leu Leu Ala Gly Ala Ser Arg Leu Leu Ala 
            20                  25                  30          


Gly Phe Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Tyr Phe Pro Gln Pro Pro Lys Gln Lys Trp Phe Trp Gly Gln Pro 
    50                  55                  60                  


Gly Pro Gln Glu Gly Leu Lys Asn Leu Thr Gln Met Ser Ala Thr Tyr 
65                  70                  75                  80  


Pro Gln Gly Phe Arg Ile Trp Leu Gly Pro Ile Phe Pro Phe Ile Val 
                85                  90                  95      


Leu Cys His Pro Asp Ile Val Arg Ser Ile Thr Asn Ala Ser Ala Ala 
            100                 105                 110         


Ile Ala Pro Lys Asp Asp Leu Ser Ile Arg Phe Leu Lys Pro Trp Leu 
        115                 120                 125             


Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp Ser Arg His Arg 
    130                 135                 140                 


Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu Lys Pro Tyr Ile 
145                 150                 155                 160 


Lys Ile Phe Asn Arg Ser Val Asn Ile Met His Asp Lys Trp Gln His 
                165                 170                 175     


Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe Glu His Ile Ser 
            180                 185                 190         


Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe Ser Phe Asp Ser 
        195                 200                 205             


His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr Ile Leu Glu Leu 
    210                 215                 220                 


Ser Ala Leu Val Glu Lys Arg Asn Gln His Ile Leu Gln His Met Asp 
225                 230                 235                 240 


Phe Leu Tyr Tyr Leu Ser His Asp Gly Trp Arg Phe Arg Arg Ala Cys 
                245                 250                 255     


Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln Glu Arg Arg His 
            260                 265                 270         


Thr Leu Pro Thr Gln Gly Ile Asp Glu Asp Gly Lys Val Leu Ser Asp 
        275                 280                 285             


Glu Asp Val Arg Ala Glu Ala Asp Thr Phe Met Phe Ala Gly His Asp 
    290                 295                 300                 


Thr Thr Ala Ser Gly Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His 
305                 310                 315                 320 


Pro Glu Tyr Gln Glu His Cys Arg Gln Glu Val Gln Glu Leu Leu Lys 
                325                 330                 335     


Asp Arg Asp Pro Lys Glu Ile Glu Trp Tyr Asp Leu Ala Gln Leu Pro 
            340                 345                 350         


Phe Leu Thr Met Cys Val Lys Glu Ser Leu Arg Leu His Pro Pro Val 
        355                 360                 365             


Pro Tyr Thr Ser Arg His Arg Ile Trp Asp Ile Val Leu Pro Asp Gly 
    370                 375                 380                 


Ile Ile Cys Ile Ile Asn Ile Ile Gly Ile His His Asn Pro Thr Val 
385                 390                 395                 400 


Tyr Asn Pro Phe Arg Phe Asn Ser Glu Asn Ser Lys Glu Arg Ser Pro 
                405                 410                 415     


Leu Ala Phe Ile Pro Phe Ser Ala Gly Pro Ser Leu Trp Glu Asn Val 
            420                 425                 430         


His Arg Met Gly Ala Asp Leu Gly Ala Val Glu Asp Pro Gly Pro Gly 
        435                 440                 445             


Phe Arg Arg Asp Gly Ala Gln Met Arg Ile Leu Gly Ala Val Thr Val 
    450                 455                 460                 


Pro Thr Pro Thr Arg Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala 
465                 470                 475                 480 


Lys Met Lys Val Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Phe Leu 
                485                 490                 495     


Leu Asp His Thr Glu Pro Arg Arg Lys Pro Glu Leu Ile Met Arg Ala 
            500                 505                 510         


Glu Gly Gly Leu Trp Leu Arg Val Glu Pro Leu Asn Ala Gly Leu Gln 
        515                 520                 525             


<210>  1795
<211>  948
<212>  DNA
<213>  Homosapiens

<400>  1795
atgcaggggc taaaccacac ctccgtgtct gaattcatcc tcgttggctt ctctgccttc     60

ccccacctcc agctgatgct cttcctgctg ttcctgctga tgtacctgtt cacgctgctg    120

ggcaacctgc tcatcatggc cactgtctgg agcgagcgca gcctccacat gcccatgtac    180

ctcttcctgt gtgccctctc catcaccgag atcctctaca ccgtggccat catcccgcgc    240

atgctggccg acctgctgtc cacccagcgc tccatcgcct tcctggcctg tgccagtcag    300

atgttcttct ccttcagctt cggcttcacc cactccttcc tgctcactgt catgggctac    360

gaccgctacg tggccatctg ccaccccctg cgttacaacg tgctcatgag cctgcggggc    420

tgcacctgcc gggtgggctg ctcctgggct ggtggcttgg tcatggggat ggtggtgacc    480

tcggccattt tccacctcgc cttctgtgga cacaaggaga tccaccattt cttctgccac    540

gtgccacctc tgttgaagtt ggcctgtgga gatgatgtgc tggtggtggc caaaggcgtg    600

ggcttggtgt gtatcacggc cctgctgggc tgttttctcc tcatcctcct ctcctatgcc    660

ttcatcgtgg ccgccatctt gaagatccct tctgctgaag gtcggaacaa ggccttctcc    720

acctgtgcct ctcacctcac tgtggtggtc gtgcactatg gctttgcctc cgtcatttac    780

ctgaagccca aaggtcccca gtctccggaa ggagacacct tgatgggcat cacctacacg    840

gtcctcacac ccttcctcag ccccatcatc ttcagcctca ggaacaagga gctgaaggtc    900

gccatgaaga agacttgctt caccaaactc tttccacaga actgctga                 948


<210>  1796
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  1796

Met Gln Gly Leu Asn His Thr Ser Val Ser Glu Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 
        35                  40                  45              


Val Trp Ser Glu Arg Ser Leu His Met Pro Met Tyr Leu Phe Leu Cys 
    50                  55                  60                  


Ala Leu Ser Ile Thr Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 
65                  70                  75                  80  


Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 
                85                  90                  95      


Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 
            100                 105                 110         


Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Asn Val Leu Met Ser Leu Arg Gly Cys Thr Cys Arg 
    130                 135                 140                 


Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr 
145                 150                 155                 160 


Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His 
                165                 170                 175     


Phe Phe Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp 
            180                 185                 190         


Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu 
        195                 200                 205             


Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 
    210                 215                 220                 


Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala 
                245                 250                 255     


Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro Gln Ser Pro Glu Gly Asp 
            260                 265                 270         


Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro 
        275                 280                 285             


Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys 
    290                 295                 300                 


Thr Cys Phe Thr Lys Leu Phe Pro Gln Asn Cys 
305                 310                 315 


<210>  1797
<211>  957
<212>  DNA
<213>  Homosapiens

<400>  1797
atgcagagag ccaatcactc cacagtgacc caattcatcc tcgtcggctt ctctgtcttc     60

ccccacctcc agctgatgct cttcctgctg ttcctgctga tgtacctgtt cacgctgctg    120

ggcaacctgc tcatcatggc caccgtctgg agcgagcgca gcctccacac gcccatgtac    180

ctcttcctgt gcgccctctc cgtctccgag atcctctaca ccgtggccat catcccgcgc    240

atgctggccg acctgctgtc cacccagcgc tccatcgcct tcctggcctg tgccagtcag    300

atgttcttct ccttcagctt cggcttcacc cactccttcc tgctcaccgt catgggctac    360

gaccgctacg tggccatctg ccaccccctg cgctacaacg tgctcatgag cccgcggggc    420

tgcgcctgcc tggtgggctg ctcctgggct ggtggcttgg tcatggggat ggtggtgacc    480

tcggccattt tccacctcgc cttctgtgga cacaaggaga tccaccattt tgcttgccat    540

gtgccacctc tgttgaagtt ggcctgtgga gacgatgtgc tggtggtggc caaaggcgtg    600

ggcttggtgt gtatcacggc cctgctgggc tgttttctcc tcatcctcct ctcctatgcc    660

ttcatcgtgg ccgccatctt gaagatccct tctgctgaag gtcggaacaa ggccttctcc    720

acctgtgcct ctcacctcac tgtggtggtc gtgcactatg gctttgcctc cgtcatttac    780

ctgaagccca aaagtcccca gtctctggaa ggagacacct tgatgggcat cacctacacg    840

gtcctcacac ccttcctcag ccccatcatc ttcagcctca ggaacaagga gctgaaggtc    900

gccatgaaga agaccttctt cagtaaactc tacccagaaa aaaatgtaat gatgtag       957


<210>  1798
<211>  318
<212>  PRT
<213>  Homosapiens

<400>  1798

Met Gln Arg Ala Asn His Ser Thr Val Thr Gln Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Ser Val Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 
        35                  40                  45              


Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Cys 
    50                  55                  60                  


Ala Leu Ser Val Ser Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 
65                  70                  75                  80  


Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 
                85                  90                  95      


Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 
            100                 105                 110         


Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Cys Leu 
    130                 135                 140                 


Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr 
145                 150                 155                 160 


Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His 
                165                 170                 175     


Phe Ala Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp 
            180                 185                 190         


Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu 
        195                 200                 205             


Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 
    210                 215                 220                 


Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala 
                245                 250                 255     


Ser Val Ile Tyr Leu Lys Pro Lys Ser Pro Gln Ser Leu Glu Gly Asp 
            260                 265                 270         


Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro 
        275                 280                 285             


Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys 
    290                 295                 300                 


Thr Phe Phe Ser Lys Leu Tyr Pro Glu Lys Asn Val Met Met 
305                 310                 315             


<210>  1799
<211>  771
<212>  DNA
<213>  Homosapiens

<400>  1799
atgtggattg cagtggagac gctggcgtta gagaatgcgg ggagggaaac gttcattaca     60

agatttacgg ccagcccaag ggggagcgag gctgggggac cgggtcgcgg agacccggct    120

tcgcacacct tttggaagac tcagggagaa gcgggggccg ccttcggggg gaaaggcggg    180

actggggagc ccacaggcca tggctcctcc cacaggatcc ccaggccgga ggcgggatcc    240

ccccatgatc ctcccgtggc ccccgcacaa tctggggaga tgcggagctg cccagagagg    300

gctctggggc gacagtcact gcgcagggac aggacaggac tcccggagtc ccagctgccg    360

gcccagcccc accctgcggc cgagaggacc gagggccgag ctgctccagg ggaactcggg    420

tcccagaccc cggagtcgca gcggacaggc ccgggtcccg ccacagccag atccggctgg    480

ttccaccagc tcctcctccg gtctcgggac gtccggcccc gcacactcag catttccggc    540

ttccgggtgt cccggcgtcc tcccctgggc ctgctcacgt cgcagagggg cggcgacggg    600

gattagaggg gaggagggcc tgcgcgagca gcaaagaccc caaaccccaa aaaacaaaga    660

aaccgccaga aactgaagct tccacagccc gccacgtccc ccggctacgg ctacgctcct    720

gattggatag ttagtacggc ccctagtgcc cctgattgga taccgcttca g             771


<210>  1800
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1800

Met Trp Ile Ala Val Glu Thr Leu Ala Leu Glu Asn Ala Gly Arg Glu 
1               5                   10                  15      


Thr Phe Ile Thr Arg Phe Thr Ala Ser Pro Arg Gly Ser Glu Ala Gly 
            20                  25                  30          


Gly Pro Gly Arg Gly Asp Pro Ala Ser His Thr Phe Trp Lys Thr Gln 
        35                  40                  45              


Gly Glu Ala Gly Ala Ala Phe Gly Gly Lys Gly Gly Thr Gly Glu Pro 
    50                  55                  60                  


Thr Gly His Gly Ser Ser His Arg Ile Pro Arg Pro Glu Ala Gly Ser 
65                  70                  75                  80  


Pro His Asp Pro Pro Val Ala Pro Ala Gln Ser Gly Glu Met Arg Ser 
                85                  90                  95      


Cys Pro Glu Arg Ala Leu Gly Arg Gln Ser Leu Arg Arg Asp Arg Thr 
            100                 105                 110         


Gly Leu Pro Glu Ser Gln Leu Pro Ala Gln Pro His Pro Ala Ala Glu 
        115                 120                 125             


Arg Thr Glu Gly Arg Ala Ala Pro Gly Glu Leu Gly Ser Gln Thr Pro 
    130                 135                 140                 


Glu Ser Gln Arg Thr Gly Pro Gly Pro Ala Thr Ala Arg Ser Gly Trp 
145                 150                 155                 160 


Phe His Gln Leu Leu Leu Arg Ser Arg Asp Val Arg Pro Arg Thr Leu 
                165                 170                 175     


Ser Ile Ser Gly Phe Arg Val Ser Arg Arg Pro Pro Leu Gly Leu Leu 
            180                 185                 190         


Thr Ser Gln Arg Gly Gly Asp Gly Asp 
        195                 200     


<210>  1801
<211>  447
<212>  DNA
<213>  Homosapiens

<400>  1801
catgattgaa ggcagggatg ctagcagcaa ggaccccaaa gaattatcag cattggggcc     60

caaacttccc cccaggctgg gggaaactgg acttcctgac atcaactaac caggcgacat    120

cctggatagg cctcttcaaa gatggccaag gaagtgccca caggtggatg gatggctcag    180

cccccaccta cataaactgg gactccagga aattggatga taatggaacc accccagcct    240

gtgtgatgat gctctaccag ggacactgga gcaactcctc ttgcaaatca gagtctcctg    300

tttacatctg tgagaagagg cagagctgct gacctaggcc cctaccccat aagattggtg    360

taaacctctt gttgtgcatc ctcaacctcc atccctgccc tctctgggct ctgaatcccc    420

agaggcaaca ataaaggacg tttctcc                                        447


<210>  1802
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  1802

Met Leu Ala Ala Arg Thr Pro Lys Asn Tyr Gln His Trp Gly Pro Asn 
1               5                   10                  15      


Phe Pro Pro Gly Trp Gly Lys Leu Asp Phe Leu Thr Ser Thr Asn Gln 
            20                  25                  30          


Ala Thr Ser Trp Ile Gly Leu Phe Lys Asp Gly Gln Gly Ser Ala His 
        35                  40                  45              


Arg Trp Met Asp Gly Ser Ala Pro Thr Tyr Ile Asn Trp Asp Ser Arg 
    50                  55                  60                  


Lys Leu Asp Asp Asn Gly Thr Thr Pro Ala Cys Val Met Met Leu Tyr 
65                  70                  75                  80  


Gln Gly His Trp Ser Asn Ser Ser Cys Lys Ser Glu Ser Pro Val Tyr 
                85                  90                  95      


Ile Cys Glu Lys Arg Gln Ser Cys 
            100                 


<210>  1803
<211>  2360
<212>  DNA
<213>  Homosapiens

<400>  1803
agcagacaga gagaggaggt tgtctgggac agactgctcc tgacagaagg atgtcccagc     60

tgagcctgtc ctggctgggc ctctggccag tggcagcatc cccttggctg ctcctcctgc    120

tggtcggggc ctcctggctc ctggcccatg tcctggcctg gacctacgcc ttctatgaca    180

actgccgccg ccttcggtgt ttcccacaac ccccaagacg gaactggttt tggggacacc    240

agggcatggt caaccccaca gaggagggca tgagagttct gactcagctg gtggccacct    300

acccccaggg ctttaaggtc tggatgggac ccatctcccc cctcctcagt ttgtgccacc    360

ccgacatcat ccggtctgtc atcaacgcct cagctgccat tgcaccaaag gacaagttct    420

tctacagctt cctggagccc tggctggggg atgggctcct gctgagtgct ggtgacaagt    480

ggagccgcca ccgtcggatg ctgacgcctg ccttccattt caacatcctg aagccctata    540

tgaagatttt caatgagagt gtgaacatca tgcacgccaa gtggcagctc ctggcctcag    600

agggtagtgc ctgtttggat atgtttgagc acatcagcct catgaccttg gacagtctac    660

agaaatgtgt cttcagcttt gacagccatt gtcaggagaa acccagtgaa tatattgccg    720

ccatcttgga gctcagtgcc cttgtatcaa aaagacacca tgagatcctc ctgcatattg    780

acttcctgta ttatctcacc cctgatgggc agcgtttccg cagggcctgc cgcctggtgc    840

acgacttcac agatgccgtc atccaggagc ggcgccgcac tctccctagc cagggtgttg    900

atgacttcct ccaagccaag gccaaatcca agactttgga cttcattgat gtactcctgc    960

tgagcaagga tgaagacggg aagaagttat ctgatgagga cataagagca gaagctgaca   1020

cctttatgtt tgagggccat gacaccacgg ccagtggtct ctcctgggtc ctgtaccacc   1080

ttgcaaagca cccagaatac caggagcgct gccggcagga ggtgcaagaa cttctgaagg   1140

accgtgagcc taaagagatt gaatgggacg acctggccca tttgcccttc ctgaccatgt   1200

gcatgaagga gagcctgcgg ctgcatcccc cagtcccggt catctcccgc catgtcaccc   1260

aggacattgt gctcccagac ggccgggtca tccccaaagg cattatctgc ctcatcagtg   1320

ttttcggaac ccatcacaac ccagctgtgt ggccggaccc tgaggtctac gacccctttc   1380

gctttgaccc agagaacatc aaggagaggt cacctctggc ttttattccc ttctcggcag   1440

ggcccaggaa ctgcatcggg cagacgttcg cgatggcgga gatgaaggtg gtcctggcgc   1500

tcacgctgct gcgcttccgc gtcctgcctg accacaccga gccccgcagg aagccggagc   1560

tggtcctgcg cgcagagggc ggactttggc tgcgggtgga gcccctgagc tgagttctgc   1620

agagacccac tctgacccca ctaaaatgac ccctgattca tcaaaagtga agcctagaat   1680

taccctaaga ccctgttcca cagtcctgta ttccatccta gatatctact caaaataatt   1740

gagacaagtg ttcaaacaga aagacgcttg tgcgtgaatg ttcatggcgg ccctattcac   1800

agtagccaaa cgatgaaaac aaccccaagc tatatattac cagatgaaag gataaacaaa   1860

atgtggtcca tccatacaat ggagtattac acagccataa aaaggaatga agcagtgatc   1920

cctactacac tgtggatgaa ccttgaatgc atgatactga atgaaagacg tcagatgcaa   1980

aaggtcacat agtgtactgt ccttttatac gaaatttcca gaacaggcca atctgaagag   2040

atgcatagcg gattggtggc tttcagcagc tgtggggagg tgggactgag gagcgactgc   2100

taatcagtat ggggtttcct cccgggatgg tgaaaatgtt ccggacctag atactgacga   2160

aggtagcacg acactgtgag tgcactaaat gctattgaat tggacacttt gaaatggtga   2220

atttcgtggt atgtgaattc tacctcaatc aaaaaaattt gctattttat ctcacataca   2280

ttttttttct gtccaggttg ttcatataat aatatgctgt gagcatcttt ccatgacatt   2340

aaatcatctt aggaaacatt                                               2360


<210>  1804
<211>  520
<212>  PRT
<213>  Homosapiens

<400>  1804

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Val Asn Pro Thr Glu Glu Gly Met Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Lys Val Trp Met Gly Pro Ile Ser 
                85                  90                  95      


Pro Leu Leu Ser Leu Cys His Pro Asp Ile Ile Arg Ser Val Ile Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Cys Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Ser Lys Arg His His Glu Ile Leu 
225                 230                 235                 240 


Leu His Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala His Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Met Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


His Val Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Thr Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  1805
<211>  3044
<212>  DNA
<213>  Homosapiens

<400>  1805
atctgcctcc agcactgccc atccttgccc ctttccactg tccttggagc ttcctgggcc     60

cttccctggg cctcaggatc ccaccctcca tcccgtctgc cctgcaggat gccgcagctg    120

agcctgtcct ggctgggcct cgggcccgtg gcagcatccc cgtggctgct tctgctgctg    180

gttgggggct cctggctcct ggcccgcgtc ctggcctgga cctacacctt ctatgacaac    240

tgccgccgcc tccagtgttt tcctcaaccc ccgaaacaga actggttttg gggacaccag    300

ggcctggtca ctcccacgga agagggcatg aagacattga cccagctggt gaccacatat    360

ccccagggct ttaagttgtg gctgggtcct accttccccc tcctcatttt atgccaccct    420

gacattatcc ggcctatcac cagtgcctca gctgctgtcg cacccaagga tatgattttc    480

tatggcttcc tgaagccctg gctgggggat gggctcctgc tgagtggtgg tgacaagtgg    540

agccgccacc gtcggatgtt gacgcctgcc ttccatttca acatcttgaa gccttatatg    600

aagattttca acaagagtgt gaacatcatg cacgacaagt ggcagcgcct ggcctcagag    660

ggcagcgcca gactggacat gtttgaacac atcagcctca tgaccttgga cagtctgcag    720

aaatgtgtct tcagctttga aagcaattgt caggagaagc ccagtgaata tattgccgcc    780

atcttggagc tcagtgcctt tgtagaaaag agaaaccagc agattctctt gcacacggac    840

ttcctgtatt atctcactcc tgatgggcag cgcttccgca gggcctgcca cctggtgcac    900

gacttcacag atgccgtcat ccaggagcgg cgccgcaccc tccccactca gggtattgat    960

gatttcctca agaacaaggc aaagtccaag actttagact tcattgatgt gcttctgctg   1020

agcaaggatg aagatgggaa ggaattgtct gatgaggaca taagagcaga agctgacacc   1080

ttcatgtttg agggccatga cactacagcc agtggtctct cctgggtcct ataccacctt   1140

gcaaagcacc cagaatacca ggaacagtgc cggcaagaag tgcaagagct tctgaaggac   1200

cgtgaaccta tagagattga atgggacgac ctggcccagc tgcccttcct gaccatgtgc   1260

attaaggaga gcctgcggtt gcatccccca gtcccggtca tctcccgatg ttgcacgcag   1320

gactttgtgc tcccagacgg ccgcgtcatc cccaaaggca ttgtctgcct catcaatatt   1380

atcgggatcc attacaaccc aactgtgtgg ccagaccctg aggtctacga ccccttccgt   1440

ttcgaccaag agaacatcaa ggagaggtca cctctggctt ttattccctt ctcggcaggg   1500

cccagaaact gcatcgggca ggcgttcgcc atggctgaga tgaaggtggt cctggcgctc   1560

accctgctgc acttccgcat cctgccgacc cacactgaac cccgcaggaa acccgagctg   1620

atattgcgcg cagagggtgg actttggctg cgggtggagc ccctgggtgc gaactcacag   1680

tgactgtcct acccacccac ccacctctgt agagtcccag aaacaaaact atgctgacac   1740

ctctgcttga gcctcgttga cagccagcat ggggctcctg gggactggtg ggatctaaga   1800

aagggaggtg agtgggtgga ggcagggtga cgtctctgaa cccaaaaccc tgacggcctc   1860

tctggctgag cacagggcat ctaggccctt agtgggttct cccagagccc aagtaaaaac   1920

tttatcctgt gggcagtagg gagccctggg aggtgtttga gcaggagagg gaacaggatt   1980

aagaatgggt ttaaggagca agactgagac tctgattcag cgagaaacaa ccataggggc   2040

agatcccttc atctgtcctg ggaatgtcct cccaagactg gagtcctcag ctcagaacaa   2100

agggaaaggg gtgcagcttc caccctggca ggctctcaga aatttttagt tcctttttcc   2160

accaacttcc cacccctgtt tctccccctc ccagtgcgtt ctctctgtga ctctcttccc   2220

ttactttcag aggcatagga tctggagcca gactgcttgg gctcaagtcc tggctctgct   2280

gcgtgacttg agcaagttaa ttcctctctc tgtgcctcgg ttccctcaac catataatgg   2340

agacaacagc attacctata tcagggtttt cctgaggtct caatataagg gactcagagc   2400

tgtgcctggc acacaatgaa tgctaaatat atggagccat tattatttcc tgtctcagaa   2460

agtctggctg ttaaagaatg ttgtctttca agatcgttat ttctaccacg actttaaagg   2520

ctgtgttttg gaactcaaag gcaaaaattc taatatctgt gctccttgaa caacctcttc   2580

tcctagaggg ctgtgcatat aagatatgta tatatatata tatattatat atatatatat   2640

atacacacac acacacacac acacacacat atatacatat acacacacac acacacacac   2700

acacacacac acacacatat atatatatat atattttttt ttttttcctg aggatggtga   2760

aggtacctga ctgtgtgagg tggtaggaga atgagagaaa cctcagtcag tgtctcaaaa   2820

taaaatcctg ctacaaacat tgatctcttt tcatagccta agggatgttg catcgctaaa   2880

ccctgttgac ttctctaatc tcttctgtag ctgatctcct tcccttgcta cactcggtta   2940

ctctggcctt gattctgatc tccaaataca ttatattttt tatttgggac catcgtattg   3000

cctttgcacc tttatcaaat ataagttgcc tatatttatt tgga                    3044


<210>  1806
<211>  524
<212>  PRT
<213>  Homosapiens

<400>  1806

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Val Cys Leu Ile Asn Ile Ile Gly Ile His Tyr Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Gln Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu His Phe Arg Ile Leu Pro Thr His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Ile Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly Ala Asn Ser Gln 
        515                 520                 


<210>  1807
<211>  951
<212>  DNA
<213>  Homosapiens

<400>  1807
atgcctagtc agaactatag catcatatct gaatttaacc tctttggctt ctcagccttc     60

ccccagcacc tcctgcccat cttgttcctg ctgtacctcc tgatgttcct gttcacattg    120

ctgggcaacc ttctcatcat ggccacaatc tggattgaac acagactcca cacacccatg    180

tacctcttct tgtgcaccct ctccgtctct gagattctgt tcactgttgc catcacccct    240

cgcatgctgg ctgatctgct ttccacccat cattccatca cctttgtggc ttgtgccaac    300

cagatgttct tctccttcat gtttggcttc actcactcct tccttctcct ggtcatgggc    360

tatgatcgct atgtggccat ctgccaccca ctgcgttaca atgtgctcat gagcccccgt    420

gactgtgccc atcttgtggc ctgtacctgg gctggtggct cagtcatggg gatgatggtg    480

acaacgatag ttttccacct cactttctgt gggtctaatg tgatccacca ttttttctgt    540

catgtgcttt ccctcttgaa gttggcctgt gaaaacaaga catcatctgt catcatgggt    600

gtgatgctgg tgtgtgtcac agccctgata ggctgtttat tcctcatcat cctctcctat    660

gtcttcattg tggctgccat cttgaggatt ccctctgccg aaggccggca caagacattt    720

tctacgtgtg tatcccacct cactgtggtg gtcacgcact atagttttgc ctcctttatc    780

tacctcaagc ccaagggcct ccattctatg tacagtgacg ccttgatggc caccacctat    840

actgtcttca cccccttcct tagcccaatc attttcagcc taaggaacaa ggagctgaag    900

aatgccataa ataaaaactt ttacagaaaa ttctgtcctc caagttcctg a             951


<210>  1808
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  1808

Met Pro Ser Gln Asn Tyr Ser Ile Ile Ser Glu Phe Asn Leu Phe Gly 
1               5                   10                  15      


Phe Ser Ala Phe Pro Gln His Leu Leu Pro Ile Leu Phe Leu Leu Tyr 
            20                  25                  30          


Leu Leu Met Phe Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala 
        35                  40                  45              


Thr Ile Trp Ile Glu His Arg Leu His Thr Pro Met Tyr Leu Phe Leu 
    50                  55                  60                  


Cys Thr Leu Ser Val Ser Glu Ile Leu Phe Thr Val Ala Ile Thr Pro 
65                  70                  75                  80  


Arg Met Leu Ala Asp Leu Leu Ser Thr His His Ser Ile Thr Phe Val 
                85                  90                  95      


Ala Cys Ala Asn Gln Met Phe Phe Ser Phe Met Phe Gly Phe Thr His 
            100                 105                 110         


Ser Phe Leu Leu Leu Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Asp Cys Ala His 
    130                 135                 140                 


Leu Val Ala Cys Thr Trp Ala Gly Gly Ser Val Met Gly Met Met Val 
145                 150                 155                 160 


Thr Thr Ile Val Phe His Leu Thr Phe Cys Gly Ser Asn Val Ile His 
                165                 170                 175     


His Phe Phe Cys His Val Leu Ser Leu Leu Lys Leu Ala Cys Glu Asn 
            180                 185                 190         


Lys Thr Ser Ser Val Ile Met Gly Val Met Leu Val Cys Val Thr Ala 
        195                 200                 205             


Leu Ile Gly Cys Leu Phe Leu Ile Ile Leu Ser Tyr Val Phe Ile Val 
    210                 215                 220                 


Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe 
225                 230                 235                 240 


Ser Thr Cys Val Ser His Leu Thr Val Val Val Thr His Tyr Ser Phe 
                245                 250                 255     


Ala Ser Phe Ile Tyr Leu Lys Pro Lys Gly Leu His Ser Met Tyr Ser 
            260                 265                 270         


Asp Ala Leu Met Ala Thr Thr Tyr Thr Val Phe Thr Pro Phe Leu Ser 
        275                 280                 285             


Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Asn 
    290                 295                 300                 


Lys Asn Phe Tyr Arg Lys Phe Cys Pro Pro Ser Ser 
305                 310                 315     


<210>  1809
<211>  1131
<212>  DNA
<213>  Homosapiens

<400>  1809
atgaaggagg gcatgagagt tctgactcag ctggtggcca cttaccccca gggctttaag     60

atctggatga accccattac tcccatcatc aggttgtgcc accccaacat catctggtct    120

gtcatcaatg cctcagccac cattgcacca aaagacgagg ccttctacaa gttcctgaag    180

ccctggctgg gggatgggct cctggtaaat gccagtgaca agtggagctg ccaccgtcag    240

atgctgatgc ccgccttcca tttcaacatg ctgaagccct atatgaagtt tttcactgac    300

agtgtgaata tcatgcacgc caagtggcag ctcctggcct cagggggcag tgcccatctg    360

gacatgtttg agcacaccag cctcatgacc ttggacagtg tgcagaaatg tgtcttcagc    420

tttgacagcc attgtcagga cggatggcgc ttccgcaggg cctgctgcct ggttcatgac    480

ttcacagaag ctatcatcca ggagcagcgc cacaccctta ctagccaggg tgttgattat    540

ttccacgaag taaaggccaa gtccaagact ttggacttca ctgatgtact cctgctgagc    600

aaggatgaag attggaagga gttgtctgat gaggaaataa gagcagaagc tgacaccttc    660

atgtttgagg atgagtgtcc cagtcataac accacggcca gtggcctctc ctgggtccta    720

tactaccttg caaggcaccc agaataccag gagcactgct gggatgacct ggcccagctg    780

cccttcctga ccatgtacat taaggacagc ctgtggctgc atcccccagt ccctgtcatc    840

tcccgatgct gcacccagga cattgtctat gaccccttcc gctttgaccc agagaatagc    900

aaagagagat cacctctggc ttttattccc ttctcagcag ggtccagaca agggaactgc    960

attgggcagg cgtttgcaat ggctgagatg aaggtggtcc tggcgctcac gctgctgtgc   1020

ttccgtgtct gtccagacca catggagccc cgcaggaagc cggaggtcat aatgtatgca   1080

gagggcggac tttggctgtg ggtgaagccc ctgagcgcag acccacagtg a            1131


<210>  1810
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  1810

Met Lys Glu Gly Met Arg Val Leu Thr Gln Leu Val Ala Thr Tyr Pro 
1               5                   10                  15      


Gln Gly Phe Lys Ile Trp Met Asn Pro Ile Thr Pro Ile Ile Arg Leu 
            20                  25                  30          


Cys His Pro Asn Ile Ile Trp Ser Val Ile Asn Ala Ser Ala Thr Ile 
        35                  40                  45              


Ala Pro Lys Asp Glu Ala Phe Tyr Lys Phe Leu Lys Pro Trp Leu Gly 
    50                  55                  60                  


Asp Gly Leu Leu Val Asn Ala Ser Asp Lys Trp Ser Cys His Arg Gln 
65                  70                  75                  80  


Met Leu Met Pro Ala Phe His Phe Asn Met Leu Lys Pro Tyr Met Lys 
                85                  90                  95      


Phe Phe Thr Asp Ser Val Asn Ile Met His Ala Lys Trp Gln Leu Leu 
            100                 105                 110         


Ala Ser Gly Gly Ser Ala His Leu Asp Met Phe Glu His Thr Ser Leu 
        115                 120                 125             


Met Thr Leu Asp Ser Val Gln Lys Cys Val Phe Ser Phe Asp Ser His 
    130                 135                 140                 


Cys Gln Asp Gly Trp Arg Phe Arg Arg Ala Cys Cys Leu Val His Asp 
145                 150                 155                 160 


Phe Thr Glu Ala Ile Ile Gln Glu Gln Arg His Thr Leu Thr Ser Gln 
                165                 170                 175     


Gly Val Asp Tyr Phe His Glu Val Lys Ala Lys Ser Lys Thr Leu Asp 
            180                 185                 190         


Phe Thr Asp Val Leu Leu Leu Ser Lys Asp Glu Asp Trp Lys Glu Leu 
        195                 200                 205             


Ser Asp Glu Glu Ile Arg Ala Glu Ala Asp Thr Phe Met Phe Glu Asp 
    210                 215                 220                 


Glu Cys Pro Ser His Asn Thr Thr Ala Ser Gly Leu Ser Trp Val Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ala Arg His Pro Glu Tyr Gln Glu His Cys Trp Asp Asp 
                245                 250                 255     


Leu Ala Gln Leu Pro Phe Leu Thr Met Tyr Ile Lys Asp Ser Leu Trp 
            260                 265                 270         


Leu His Pro Pro Val Pro Val Ile Ser Arg Cys Cys Thr Gln Asp Ile 
        275                 280                 285             


Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu Asn Ser Lys Glu Arg Ser 
    290                 295                 300                 


Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly Ser Arg Gln Gly Asn Cys 
305                 310                 315                 320 


Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val Val Leu Ala Leu 
                325                 330                 335     


Thr Leu Leu Cys Phe Arg Val Cys Pro Asp His Met Glu Pro Arg Arg 
            340                 345                 350         


Lys Pro Glu Val Ile Met Tyr Ala Glu Gly Gly Leu Trp Leu Trp Val 
        355                 360                 365             


Lys Pro Leu Ser Ala Asp Pro Gln 
    370                 375     


<210>  1811
<211>  1128
<212>  DNA
<213>  Homosapiens

<400>  1811
gccccccaga gcttggtggt gtcccaggac ggtcctccca ggaaacattt tgaataagtt     60

gctgaagtgc ctgatggacg tggctctcgt cacgaaatga gtttggatcc gagaagccct    120

cttcttcatc ggaaaacagg acaaagatga gctgcgtgcc cataattcca cgtttacgct    180

gactcctcca gtgcctcatc aatgaagtaa gcaggcagct acgttctgga tggctagcat    240

gtaccgaagg cacaaaacct ccagagttgg cagagttaag tcctggcgtg cccgaggcta    300

tccaggggaa cacgcgggac agacagcacc ctcagcctgt ccccatgacc ctctgctcca    360

gtctgagggg caggacacca tgagacctct cagacacaga gtccaccctc gacatgaccc    420

ggatgaaagg caggagtgtg tgccctgctt ttgccctcga agctcgctga aggggaccca    480

tctctgcaag cccacagccc tacctgcagc atccacagcc tcagagagca gcggggcccc    540

ttacccctga accccctcca agagcatcag gacaacaagc cttgagctgt ggagacaaga    600

gaatcagtat ccctggccca gggaggattc caggagagga cacgggcagg agccctggcc    660

cagagccaga accaagagtc cagccagagg cggctagagc atcacctctt cacgcaagtg    720

tcttgaaact cagcttgaag atttcagcaa atgtgtctta cagagaagag aagagggagt    780

cagcccatcg ggattaaaaa tatagaggca gtgacaacac acactcggct tcagttctta    840

ggagagtttt ggttttgatt tttttttttt ttttggagaa gatttttttt ttaatggatc    900

tacactgtta actgagactc tgttgagatt cactggttta cttaaaaact tctcagggat    960

gtctgtaaat ttcagtgtta tatgtcatga aaactggtgt gggcagatct gttggttgaa   1020

ataatttcta ctgtttcaaa tactgaaggc aggaataatt ggtttatact gtgttttaaa   1080

tagaagtatt actggtaagt cccccaggac attaaacctt aaaaatca                1128


<210>  1812
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  1812

Met Ala Ser Met Tyr Arg Arg His Lys Thr Ser Arg Val Gly Arg Val 
1               5                   10                  15      


Lys Ser Trp Arg Ala Arg Gly Tyr Pro Gly Glu His Ala Gly Gln Thr 
            20                  25                  30          


Ala Pro Ser Ala Cys Pro His Asp Pro Leu Leu Gln Ser Glu Gly Gln 
        35                  40                  45              


Asp Thr Met Arg Pro Leu Arg His Arg Val His Pro Arg His Asp Pro 
    50                  55                  60                  


Asp Glu Arg Gln Glu Cys Val Pro Cys Phe Cys Pro Arg Ser Ser Leu 
65                  70                  75                  80  


Lys Gly Thr His Leu Cys Lys Pro Thr Ala Leu Pro Ala Ala Ser Thr 
                85                  90                  95      


Ala Ser Glu Ser Ser Gly Ala Pro Tyr Pro 
            100                 105     


<210>  1813
<211>  1916
<212>  DNA
<213>  Homosapiens

<400>  1813
ggagtgagcg cggcagtggc cctggcagct ggcggagcgg cccagcccgt gtgcacgtgg     60

cgccggcgct gcctttcggt tgccaaaatt caggctgtag acggcgagat aacaagttta    120

aaaccccggc taagccagaa gagccaaaga gggacctcgc caaggccact cctcgctctc    180

taggccgaga atactgcgca aattctggga ggtttgggcc tggcggctct ccgttcccga    240

cccccggcgt ggattcgttc ccgcgctttc tggcgtgagg ggtcagaggg cgcgccgacg    300

ctcaggcgaa cggagcggag gcggcagcgg ccatgggcga agcgggcgcc gctgaggagg    360

cctgccggca catgggaact aaagaggaat ttgttaaagt cagaaagaag gatctggaac    420

ggctgacaac tgaagtgatg caaatacggg acttcttacc cagaatacta aatggggagg    480

tgctggagag cttccagaaa ttaaagattg tagaaaaaaa cctggaaagg aaagagcaag    540

aattagagca gctgaaaatg gattgtgagc actttaaagc ccgcctggaa accgtgcagg    600

ccgacaacat aagagagaag aaggagaaac tggctcttcg acagcagttg aatgaagcga    660

agcagcaact cctgcagcag gcagagtatt gtacagaaat gggagcagca gcgtgtaccc    720

tcttgtgggg tgtctccagc agtgaggaag tcgtcaaggc cattttggga ggagataaag    780

ctttgaagtt tttcagcatc actggtcaaa caatggagag ttttgtgaag tcgttagacg    840

gtgatgtcca ggagctggat tcggatgaaa gtcagtttgt tttcgctctg gctggaattg    900

tcacgaatgt tgctgctata gcatgtggtc gtgaattctt ggttaattca agccgggtgc    960

tcttggacac catattgcag cttctgggag acttgaagcc aggacagtgt accaaactca   1020

aagtgctaat gctgatgtcc ctatacaatg taagcatcaa tttgaaaggc ttgaaataca   1080

tcagcgagag tccaggattc atccctttgc tgtggtggct tttgagtgat ccagatgcag   1140

aggtgtgcct tcatgtactg aggcttgtcc agtctgtggt tctggaacct gaagtcttct   1200

ccaagtcggc ctctgagttc cggagctccc tgcccctgca acgcatcctg gcaatgtcca   1260

agagccgcaa cccccgcctg caaaccgcag cccaggagct cctggaagat ctccgcactc   1320

tggagcataa tgtgtaggtg tgctcggcca ccagggtttt ggtgaaaatg ccggtgtccc   1380

ttctccccag atccctcatt tgatactcca aaaccatcac catgtaccat gtgttagagt   1440

tggcaaaatg tgattgacta gagatggaca tgaattgata tgtatcccac ataactttgt   1500

cttggaagtg agagtgcttg taggtggttg gttaagcttg ccaaaggaga ggccatgaaa   1560

gaacctgtcc ttctggaaaa gtggtccatg tctgtgctgg ctggaagagg gcttgcttag   1620

ggcagcttct tgctgctcag cagaccatga cctgtaggtt cacctataaa acagggaaat   1680

tgaataacca tctaccccat tagtcagcat tttcttgaga tacatttctt tgaaaagcaa   1740

ttcattctct ctctagtaat tgtaattaat ccccccaaaa tgcaagttta cttttataac   1800

cttttggtga acctgctatt tcggatgaca ttgggcattt tagttctata ttttttgtgc   1860

ctcttttatt tttgaataaa gaaaatcaga agagttgtaa aaaaaaaaaa aaaaaa       1916


<210>  1814
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  1814

Met Gly Glu Ala Gly Ala Ala Glu Glu Ala Cys Arg His Met Gly Thr 
1               5                   10                  15      


Lys Glu Glu Phe Val Lys Val Arg Lys Lys Asp Leu Glu Arg Leu Thr 
            20                  25                  30          


Thr Glu Val Met Gln Ile Arg Asp Phe Leu Pro Arg Ile Leu Asn Gly 
        35                  40                  45              


Glu Val Leu Glu Ser Phe Gln Lys Leu Lys Ile Val Glu Lys Asn Leu 
    50                  55                  60                  


Glu Arg Lys Glu Gln Glu Leu Glu Gln Leu Lys Met Asp Cys Glu His 
65                  70                  75                  80  


Phe Lys Ala Arg Leu Glu Thr Val Gln Ala Asp Asn Ile Arg Glu Lys 
                85                  90                  95      


Lys Glu Lys Leu Ala Leu Arg Gln Gln Leu Asn Glu Ala Lys Gln Gln 
            100                 105                 110         


Leu Leu Gln Gln Ala Glu Tyr Cys Thr Glu Met Gly Ala Ala Ala Cys 
        115                 120                 125             


Thr Leu Leu Trp Gly Val Ser Ser Ser Glu Glu Val Val Lys Ala Ile 
    130                 135                 140                 


Leu Gly Gly Asp Lys Ala Leu Lys Phe Phe Ser Ile Thr Gly Gln Thr 
145                 150                 155                 160 


Met Glu Ser Phe Val Lys Ser Leu Asp Gly Asp Val Gln Glu Leu Asp 
                165                 170                 175     


Ser Asp Glu Ser Gln Phe Val Phe Ala Leu Ala Gly Ile Val Thr Asn 
            180                 185                 190         


Val Ala Ala Ile Ala Cys Gly Arg Glu Phe Leu Val Asn Ser Ser Arg 
        195                 200                 205             


Val Leu Leu Asp Thr Ile Leu Gln Leu Leu Gly Asp Leu Lys Pro Gly 
    210                 215                 220                 


Gln Cys Thr Lys Leu Lys Val Leu Met Leu Met Ser Leu Tyr Asn Val 
225                 230                 235                 240 


Ser Ile Asn Leu Lys Gly Leu Lys Tyr Ile Ser Glu Ser Pro Gly Phe 
                245                 250                 255     


Ile Pro Leu Leu Trp Trp Leu Leu Ser Asp Pro Asp Ala Glu Val Cys 
            260                 265                 270         


Leu His Val Leu Arg Leu Val Gln Ser Val Val Leu Glu Pro Glu Val 
        275                 280                 285             


Phe Ser Lys Ser Ala Ser Glu Phe Arg Ser Ser Leu Pro Leu Gln Arg 
    290                 295                 300                 


Ile Leu Ala Met Ser Lys Ser Arg Asn Pro Arg Leu Gln Thr Ala Ala 
305                 310                 315                 320 


Gln Glu Leu Leu Glu Asp Leu Arg Thr Leu Glu His Asn Val 
                325                 330                 


<210>  1815
<211>  381
<212>  DNA
<213>  Homosapiens

<400>  1815
atgccggagc cagcgaagtc cgctcccgcg cccaagaagg gctcgaagaa agccgtgact     60

aaggcgcaga agaaggacgg caggaagcgc aagcgcagcc gcaaggagag ctactccgta    120

tacgtgtaca aggtgctgaa gcaggtccac cccgacaccg gcatctcctc taaggccatg    180

ggaatcatga actccttcgt caacgacatc ttcgaacgca tcgcaggtga ggcttcccgc    240

ctgccgcatt acaacaagcg ctcgaccatc acctccaggg agatccagac ggccgtgcgc    300

ctgctgctgc ccggggagtt ggccaagcac gccgtgtccg agggcaccaa ggccgtcacc    360

aagtacacca gcgctaagta a                                              381


<210>  1816
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  1816

Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Arg Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Pro His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ala Lys 
        115                 120                 125     


<210>  1817
<211>  5087
<212>  DNA
<213>  Homosapiens

<400>  1817
cgccgccttc tgtgcagtcg cggcccgggc ggacggtggc tggctgctcc gcagcgctcg     60

gctggctgca gcggcaccgc gggttgcgcg gccggggatg ctccagcggg cgcgatggcc    120

cccgccatgc agccggccga gatccaattt gcccagcggc tggcgtccag cgagaagggc    180

atccgggacc gagcggtgaa gaagctgcgc cagtacatca gcgtgaagac gcagagggag    240

acaggaggtt tcagtcagga agaacttctg aaaatctgga aggggctctt ctactgcatg    300

tgggtgcagg atgaacccct tctacaggaa gagctcgcca acaccattgc acagctagtc    360

catgctgtta acaactcagc ggctcaacac ctgttcattc agaccttttg gcaaaccatg    420

aatcgagaat ggaaaggaat agacaggcta cgcctggaca aatactatat gctgattcgt    480

ctggtcctga ggcagtcctt tgaagtcttg aagcgaaatg gctgggaaga aagccgaatc    540

aaggttttct tggatgtcct gatgaaggag gtcctgtgtc ctgagagtca gtctcctaat    600

ggagtgagat tccacttcat tgatatttac ctggatgaac tctccaaagt cggggggaag    660

gagcttttag cagatcagaa tctcaagttt atcgatccat tctgcaaaat tgctgcgaag    720

acgaaggacc acaccctggt acagaccata gctcggggtg tcttcgaagc tatcgtagat    780

cagtctcctt ttgtgcctga agagacgatg gaggaacaga agacaaaagt gggtgatggt    840

gacctctctg ctgaggagat acctgaaaat gaggtatcct tgagaagagc tgtcagtaaa    900

aagaagacag cactgggcaa aaaccattcc agaaaagatg gactcagtga tgaaagagga    960

agagatgact gtggaacctt tgaggacaca gggccccttc tccagtttga ctataaggct   1020

gttgctgatc gactcctgga aatgaccagc aggaagaaca cgccccactt caacaggaag   1080

cgcctctcca aactcatcaa gaaattccaa gacctttctg aaggaagcag tatatctcaa   1140

ctcagttttg cggaggacat ttctgctgat gaagatgacc aaatcctcag tcaaggaaag   1200

cataagaaga aaggaaataa acttttagag aaaactaact tggaaaagga gaaaggaagc   1260

agagtctttt gtgtagagga agaggacagt gaaagcagtc ttcaaaagag aagaaggaag   1320

aagaagaaga agcaccacct gcagcctgaa aatccaggcc cagggggtgc agccccgtcc   1380

ctggaacaga accggggcag ggagcccgag gcctctgggc tgaaagccct gaaggcacgt   1440

gtggccgagc caggtgcaga ggccacgtcc agcactgggg aggagagtgg ctccgagcat   1500

cctccagccg tccccatgca caataaaagg aaacggccac ggaagaagag cccgagggcc   1560

cacagggaaa tgttggaatc agcagtgttg cccccagagg acatgtctca gagtggcccg   1620

agtggcagtc atcctcaggg acctagaggg tccccgacag gtggagccca actcctaaaa   1680

aggaagcgga aacttggagt tgtgcccgtc aatggcagtg gcctgtccac gccggcctgg   1740

cctccattgc agcaggaagg ccctcccaca ggccccgcag agggggcgaa cagccacacc   1800

acgctgcccc agcgcaggag gctgcagaaa aagaaggcag ggcccggcag cctggagctc   1860

tgtggcctgc ccagccagaa aacagcaagt ttgaaaaaga ggaagaaaat gagagtgatg   1920

tcaaacttgg tggagcacaa cggggtgctg gagtccgaag ctgggcaacc ccaggctctg   1980

ggaagcagtg ggacttgcag ttccctgaag aagcagaagc tgagggcaga gagcgacttt   2040

gtgaagtttg acaccccctt cttaccaaag cccctgttct tcagaagagc caagagcagc   2100

actgccaccc accctccagg ccctgccgtc cagctaaaca agacaccatc cagctccaag   2160

aaagtcacct ttgggctgaa cagaaacatg actgccgaat tcaagaagac agacaagagt   2220

atcttggtca gtcccacggg cccttctcga gtggccttcg accctgaaca gaagcccctc   2280

cacggggtgc tgaagacccc caccagctca cctgccagct cacccctggt ggccaagaag   2340

cccctgacca ccacaccaag gagaaggccc agggctatgg atttcttctg aggagcagca   2400

gagtcccttg taaaagactg cttttgtaca gaatgcgcta taaattatac ctttaagaat   2460

gtggggcctt ttttatgatt ttgtaagttc ccataagttg tgtgcacgag gttctgagag   2520

tgcccgcagg ctgctgcgtc ctggcccctc tgtagtggct gcgggcgtct tggttgaatc   2580

ttttgctaca aaccatgttt gcgtttgagc tctccaggat tttacatttt tgggtaacct   2640

cagtgattcc cattggtgta ggaaatgaga ccctctctga agctgaggag agcacgttga   2700

tctgaacttt aaatcaatca gtgctgctgg cacaatgaaa ggtggaactg cacttctgtt   2760

gagctctcag ttctgcggaa tttggtactc attaccgtat tcgccgtact aagttggttt   2820

ctgttagtct taacagtctg ttttctttta aaagcatgta gggcttcatt gccatgttct   2880

gtgggtgttt ggcaggttac cgatggggaa gattcttgtc acagaatcag caataccata   2940

gtttttctac atgtgctcag ctgggggtgt ggacaggtag gggtggggaa agaagaggct   3000

ctgcgttctg ggggcttttt cttctcctcc ccctacccgg tttccctccc tgttttccta   3060

cctctacggc aagcccaaag tgtcttcccg ggagcccagc gcagcccccg gctcttaccc   3120

aggaccccgc cccgtgctga gccttctgct gaggtccttg cgtggagcac actcattcct   3180

ccaagccctt gcgctcccgt ttctctctct ctccgtccac gttccagccg agtcactgcc   3240

tgaccggctc catggcagct ccccatcttc cctagaggct gcctgcgcat ctggagcctg   3300

cgctccggct cagcgacctt tcctctcaaa tgcggaagcg tgcacttaca gttcagaccg   3360

ttctcctgta agttcattac aaacacgggc ggaaggcact caggctttcg ttggagaaac   3420

agaaataagg ccttcttttg agcagcgatt gctggatcat tgatctgttt gaggaagtgt   3480

ctgacctggg cctgagagct ggagaaggtg cagattcaaa gtgagcggct cctgaggaga   3540

gccgccaagg ctgctcgcct tctccgtggc ttccgcagct accgtctgca cggtgagagg   3600

gcacgggcac acggttcggg ctggcgtgca gctctcccag ccagccacgc tctgctcagg   3660

cctggaagtg aaagccgcct ccttcccgtt atgcccccca tacaggagcc tcggtttttc   3720

agcaaaacgc ggccagtccc cttctccact gctgcctccc agcagagggc cccaggatct   3780

ccaaggtccc agctatggct ttggacaacg tggcttcggc ccctggggtt gcagagcttg   3840

cattgggttt acctcggtct cattcattca tggagccaag ggtggggttt cacctgcgaa   3900

catcagactg acttgctggc gtcaagagca gttgactcac tgatgaaggc cctggtgagg   3960

agaaagcact ctgttcttcg cctactctgt aatcgttttg tcataatgag ccatgaaaaa   4020

agtaatgaac ttgtgctgtt aatcgtcact gtaatgagaa gtcttacgta caacatagct   4080

gtggtggctt aatggctgca ttagatagga tcctcacatc ccattcagaa ccaaaactga   4140

tacagtgaaa caattaaggt gagcaaatag ttttaacttt tctttttttt ttttaagttt   4200

cattcttcct agaatatttt tctaacaatt tttatttcag ctttaaagat gggtcatata   4260

gccaaacggg ccatataatc caacattgtt gagatgtctt aggacatcta aggcaaaact   4320

ggcacatttg ttctgcagac tattgcagga atgttttttc ctagcatttc tatattatct   4380

gtccattctg aggaaccagt gaatgtccta taaatgcacc tcctgtcaaa accatgcctg   4440

agaggtcccg gctgggagtg acagggtgct tcttagattc tattggtcct tctctcattc   4500

tccgaactta ctccttttta tgggtaagtc aactaggttt acagtccctt atttttaatg   4560

cctaagtttt gacagcagga agaaaacaat tttttaaaaa ttctcattac atagacgcac   4620

aagaatatgt cacataaaga aaatgtgttt agaatactgg ttttctattt acgcatgata   4680

ttttcctaag taaaattgcc aagtggactt ggaagtccag aaaggaaaat aatttaaatt   4740

aatgctggtg atcttaacaa tattttgtaa aatgatgctt cccccttctc catggtctag   4800

tcaattttgt acaattaggt atctgacttt acaagtttgt tatcctttct aatttttact   4860

gaactgaaag cacaaagaag actacacaga aaatctggaa acagttgcag gtgttgggag   4920

gaagatgaaa tcgagctgtc ttttaacttt tgtatgtgtt ttatcagaat ttgctggact   4980

atgctggcaa ggactttgtt tacgatcaaa ttgtactagt gtctgcaggg tttgtcagta   5040

ctcgtcaaag ccaagtccaa ttaaaaaaaa aagtctttgc cctccaa                 5087


<210>  1818
<211>  758
<212>  PRT
<213>  Homosapiens

<400>  1818

Met Ala Pro Ala Met Gln Pro Ala Glu Ile Gln Phe Ala Gln Arg Leu 
1               5                   10                  15      


Ala Ser Ser Glu Lys Gly Ile Arg Asp Arg Ala Val Lys Lys Leu Arg 
            20                  25                  30          


Gln Tyr Ile Ser Val Lys Thr Gln Arg Glu Thr Gly Gly Phe Ser Gln 
        35                  40                  45              


Glu Glu Leu Leu Lys Ile Trp Lys Gly Leu Phe Tyr Cys Met Trp Val 
    50                  55                  60                  


Gln Asp Glu Pro Leu Leu Gln Glu Glu Leu Ala Asn Thr Ile Ala Gln 
65                  70                  75                  80  


Leu Val His Ala Val Asn Asn Ser Ala Ala Gln His Leu Phe Ile Gln 
                85                  90                  95      


Thr Phe Trp Gln Thr Met Asn Arg Glu Trp Lys Gly Ile Asp Arg Leu 
            100                 105                 110         


Arg Leu Asp Lys Tyr Tyr Met Leu Ile Arg Leu Val Leu Arg Gln Ser 
        115                 120                 125             


Phe Glu Val Leu Lys Arg Asn Gly Trp Glu Glu Ser Arg Ile Lys Val 
    130                 135                 140                 


Phe Leu Asp Val Leu Met Lys Glu Val Leu Cys Pro Glu Ser Gln Ser 
145                 150                 155                 160 


Pro Asn Gly Val Arg Phe His Phe Ile Asp Ile Tyr Leu Asp Glu Leu 
                165                 170                 175     


Ser Lys Val Gly Gly Lys Glu Leu Leu Ala Asp Gln Asn Leu Lys Phe 
            180                 185                 190         


Ile Asp Pro Phe Cys Lys Ile Ala Ala Lys Thr Lys Asp His Thr Leu 
        195                 200                 205             


Val Gln Thr Ile Ala Arg Gly Val Phe Glu Ala Ile Val Asp Gln Ser 
    210                 215                 220                 


Pro Phe Val Pro Glu Glu Thr Met Glu Glu Gln Lys Thr Lys Val Gly 
225                 230                 235                 240 


Asp Gly Asp Leu Ser Ala Glu Glu Ile Pro Glu Asn Glu Val Ser Leu 
                245                 250                 255     


Arg Arg Ala Val Ser Lys Lys Lys Thr Ala Leu Gly Lys Asn His Ser 
            260                 265                 270         


Arg Lys Asp Gly Leu Ser Asp Glu Arg Gly Arg Asp Asp Cys Gly Thr 
        275                 280                 285             


Phe Glu Asp Thr Gly Pro Leu Leu Gln Phe Asp Tyr Lys Ala Val Ala 
    290                 295                 300                 


Asp Arg Leu Leu Glu Met Thr Ser Arg Lys Asn Thr Pro His Phe Asn 
305                 310                 315                 320 


Arg Lys Arg Leu Ser Lys Leu Ile Lys Lys Phe Gln Asp Leu Ser Glu 
                325                 330                 335     


Gly Ser Ser Ile Ser Gln Leu Ser Phe Ala Glu Asp Ile Ser Ala Asp 
            340                 345                 350         


Glu Asp Asp Gln Ile Leu Ser Gln Gly Lys His Lys Lys Lys Gly Asn 
        355                 360                 365             


Lys Leu Leu Glu Lys Thr Asn Leu Glu Lys Glu Lys Gly Ser Arg Val 
    370                 375                 380                 


Phe Cys Val Glu Glu Glu Asp Ser Glu Ser Ser Leu Gln Lys Arg Arg 
385                 390                 395                 400 


Arg Lys Lys Lys Lys Lys His His Leu Gln Pro Glu Asn Pro Gly Pro 
                405                 410                 415     


Gly Gly Ala Ala Pro Ser Leu Glu Gln Asn Arg Gly Arg Glu Pro Glu 
            420                 425                 430         


Ala Ser Gly Leu Lys Ala Leu Lys Ala Arg Val Ala Glu Pro Gly Ala 
        435                 440                 445             


Glu Ala Thr Ser Ser Thr Gly Glu Glu Ser Gly Ser Glu His Pro Pro 
    450                 455                 460                 


Ala Val Pro Met His Asn Lys Arg Lys Arg Pro Arg Lys Lys Ser Pro 
465                 470                 475                 480 


Arg Ala His Arg Glu Met Leu Glu Ser Ala Val Leu Pro Pro Glu Asp 
                485                 490                 495     


Met Ser Gln Ser Gly Pro Ser Gly Ser His Pro Gln Gly Pro Arg Gly 
            500                 505                 510         


Ser Pro Thr Gly Gly Ala Gln Leu Leu Lys Arg Lys Arg Lys Leu Gly 
        515                 520                 525             


Val Val Pro Val Asn Gly Ser Gly Leu Ser Thr Pro Ala Trp Pro Pro 
    530                 535                 540                 


Leu Gln Gln Glu Gly Pro Pro Thr Gly Pro Ala Glu Gly Ala Asn Ser 
545                 550                 555                 560 


His Thr Thr Leu Pro Gln Arg Arg Arg Leu Gln Lys Lys Lys Ala Gly 
                565                 570                 575     


Pro Gly Ser Leu Glu Leu Cys Gly Leu Pro Ser Gln Lys Thr Ala Ser 
            580                 585                 590         


Leu Lys Lys Arg Lys Lys Met Arg Val Met Ser Asn Leu Val Glu His 
        595                 600                 605             


Asn Gly Val Leu Glu Ser Glu Ala Gly Gln Pro Gln Ala Leu Gly Ser 
    610                 615                 620                 


Ser Gly Thr Cys Ser Ser Leu Lys Lys Gln Lys Leu Arg Ala Glu Ser 
625                 630                 635                 640 


Asp Phe Val Lys Phe Asp Thr Pro Phe Leu Pro Lys Pro Leu Phe Phe 
                645                 650                 655     


Arg Arg Ala Lys Ser Ser Thr Ala Thr His Pro Pro Gly Pro Ala Val 
            660                 665                 670         


Gln Leu Asn Lys Thr Pro Ser Ser Ser Lys Lys Val Thr Phe Gly Leu 
        675                 680                 685             


Asn Arg Asn Met Thr Ala Glu Phe Lys Lys Thr Asp Lys Ser Ile Leu 
    690                 695                 700                 


Val Ser Pro Thr Gly Pro Ser Arg Val Ala Phe Asp Pro Glu Gln Lys 
705                 710                 715                 720 


Pro Leu His Gly Val Leu Lys Thr Pro Thr Ser Ser Pro Ala Ser Ser 
                725                 730                 735     


Pro Leu Val Ala Lys Lys Pro Leu Thr Thr Thr Pro Arg Arg Arg Pro 
            740                 745                 750         


Arg Ala Met Asp Phe Phe 
        755             


<210>  1819
<211>  7380
<212>  DNA
<213>  Homosapiens

<400>  1819
cggaactcgc gggttcggag ccgcccgctg aggtcagaag gaggcgtctg cgctgatcgg     60

gtccgccgcg cgccagagcc agagtcgcag ccgaggggag ccggggccgg agcccgagcc    120

cgagccgagc cggagcccga gcgagcggcg gagaccgtgc ccccgcctcg gccccgcgcc    180

gccgcggcca ggcccggcat ggaggaggag tgccgggtgc tctccataca gagccacgtc    240

atccgcggct acgtgggcaa ccgggcggcc acgttcccgc tgcaggtttt gggatttgag    300

attgacgcgg tgaactctgt ccagttttca aaccacacag gctatgccca ctggaagggc    360

caagtgctga attcagatga gctccaggag ttgtacgaag gcctgaggct gaacaacatg    420

aataaatatg actacgtgct cacaggttat acgagggaca agtcgttcct ggccatggtg    480

gtggacattg tgcaggagct gaagcagcag aaccccaggc tggtgtacgt gtgtgatcca    540

gtcttgggtg acaagtggga cggcgaaggc tcgatgtacg tcccggagga cctccttccc    600

gtctacaaag aaaaagtggt gccgcttgca gacattatca cgcccaacca gtttgaggcc    660

gagttactga gtggccggaa gatccacagc caggaggaag ccttgcgggt gatggacatg    720

ctgcactcta tgggccccga caccgtggtc atcaccagct ccgacctgcc ctccccgcag    780

ggcagcaact acctgattgt gctggggagt cagaggagga ggaatcccgc tggctccgtg    840

gtgatggaac gcatccggat ggacattcgc aaagtggacg ccgtctttgt gggcactggg    900

gacctgtttg ctgccatgct cctggcgtgg acacacaagc accccaataa cctcaaggtg    960

gcctgtgaga agaccgtgtc taccttgcac cacgttctgc agaggaccat ccagtgtgca   1020

aaagcccagg ccggggaagg agtgaggccc agccccatgc agctggagct gcggatggtg   1080

cagagcaaaa gggacatcga ggacccagag atcgtcgtcc aggccacggt gctgtgaggg   1140

ccccgccgct tgcccgtgac acgcagcgcg ttggtgtctc cgtgtttgtc cctgtgaaaa   1200

catgtaacgt ctgccttaga gccatgaccg aaacttgata tttttttctt tcatgagtgt   1260

ccggcatctg ctggtcttca ttgtgaaacg tgccagtcgt gctttgtgaa aaataacaaa   1320

gtggtcacag aaatttgtga tctgaaaacc cggctccctt ccccacaagg ctcctgggcc   1380

tccgggaaga cgggcccctg tttgccatct cgggggtgtt ccctgtggga gggtgagtgg   1440

gtgaggccga gcctgctgcg tgtggagcct cgagtgggcc ctggctgcca ctaccgtaca   1500

gaggccgtgt cgcgctgggc tgggcctggg tggcctctgt ctttgcatct ctgagaagga   1560

gtcgggtggt aacggttggg gtcaggaaga attctgccaa gtatctttac tgtcattctg   1620

accatagcct ctttgttccc gcattcgaac ttttggttct tactttgctg ctcgtttagt   1680

ccctggggat ttcagatctt aggctgttgt ttcaccgtat gggagggttg atgtgagctt   1740

gcttggagac acacggtgca gcatcaggga ccttcccagg ccccagcaaa ttcaagtcgg   1800

tctgcagacc tctcagctac ccgcgggacc tcttgtaacc catcggcatc ttccaggaat   1860

ccgccgagtg acttgaggaa gatgctaacg cagtaaggtc tgtgctgggc caagagcagc   1920

tttgaagctc cagagaacca ccccgtcagg ttccttgtgg aagctcccct catccgtggt   1980

gcagcaggct gagcactgcg cgtttgccac gtgctgcccg tgacagcaca ttgagccaca   2040

gcatttgtag acaggacaga ggggtgcctg ccccctgccc ctgctggcac atttaaccct   2100

tgtcccctga cctcagttct gtgccccacc aaatgcccag gggcaagagg ccaccctgga   2160

agctgccaat cttccaaggt gggtgtgggg cacggtgggg gcgggcagct cccaggccct   2220

tgggcaggct ggggtgacgg cagaggccac agcaccagct ctgacaagtc ctatcatcct   2280

ctgctcagca gtgacctccc tggccccact ttgcccagag tttggggtcc ccccaggtat   2340

agctataggc ggcagtgcct gtccctggcc tgccttgatt tcagccacac ccctgcagcc   2400

ctgcatccca gctctggggt gtgcagaggt ttgtgtctcc agggaaccca cggctggaga   2460

gaaataggga gatgcaggaa gtgggggccc atggggcccc caagaagcgg actctccaag   2520

gggtaccccc accccgctac cttccccacg gacgggcccc tcctggagcc cataccctcc   2580

tgtgaggcca ttccagtgtc ttctagaaag actcgcttgc caggagtgcg ttctttgttg   2640

aaaaatgccc tgaagcgaaa agatgcaggt ttatatggaa cccccacccc ctcccccact   2700

ctcccactct gttcgttctg aatgtcttca cgagcgtgca tcagggcgcc tggctccccc   2760

acctcagcca gtgagtcaga cacgggtttc gcagccatgt ttcctggctc cgaggacacg   2820

ggtggcaggc ccgttgcagc ccagagccac tggtccctac agggcgccgc cacaccagca   2880

ggaaggagga tggctgtgtc cggagcctgg cggggaggcg gcctccccag tatgtgagtg   2940

cagggatctg ccagaaccac ctggccctct gtagggcgtt taactggaaa taccctcact   3000

gccaagtgga gactggggcg tgtgccacat tgccagccac caggaaagct tttctttttc   3060

tttttttttt ttttttaaac accaagagca cgtatagcat gggggaaaga acctaaatgt   3120

ctctctgtcc tgtgagctgg tgaaaaaccc agcatgagaa cgcagtgtca ggtgtgggac   3180

tccttctgcc cctgcagtgg gtgttacggg cggtgtgccc tggcgagcaa gctttgattc   3240

ttggttcttt gagctcgttt cagaggctga gtccccacat cagctttagt tcttggactt   3300

ccctgtatta agcaagaatt aggagaatgg ctgtccctgc aggcgcctcc cgtaaatcct   3360

gagctctctg gcgcaatctg aaacttctct tctgttttct ttggctgtat cagccgaacc   3420

aggagaggcc tgggctgcga ctaaggagaa agaaatcggg ggtttctgag agcagatggt   3480

gcctttgtgg gtgcagggct tttgtggaaa ttgtcagcct ctacgggcag agtccggcat   3540

cccctcccca gactgcctgc tgtcaaacca cggagcagct ggagcctgcc ctgtccacgg   3600

cccgtttcca cccgggcatg ttcgtctctc atgacttcgg cagaggcccc tggtggcctt   3660

cagtttcagt ttctcatcca ggaaggtaac cttgggcatt ggcagtgggt ttccctatgg   3720

cttggatcca gattagaatt gatctttgtt ttcactttcc atagttaata acatgcaaaa   3780

taatgagaag aatttatttt aaggtgacag ctatactggt ccaacatcgc ctgcttattg   3840

tcagggtaca gaagtttaat actttcttaa tccagttttt caaacttctc cctgtagacc   3900

gtaaggatga attccacaat aggatccttt ttaaaatcga ttttaaattg ttgcctagtc   3960

ctgccaaggt tattatgtgc atctgttatt tttccaatac atgtaaacag ttgcagcatg   4020

atgctttgtt taatgtcctg ttcttaagct cgttagagcc agttttgaaa cgtttggtct   4080

taccgtgaac ggaggctggc ttggcttagc cacgctgatg agtaagtgag ggatgtctcc   4140

atcttgagat caccaggcaa gagagttgcc tgcaccaggt aagaggccaa agcccctggg   4200

gtaacagtcc ccaccgctac ccgaggtaaa acaataaaag ctatgtggtt gagctcaggc   4260

ctctcgtgcc tggtgtcaga gaaggcagag cccacagtag gtgcagggtg caaggccctg   4320

ggagggcact ggccagggaa ggtggtatag atggccctca gattgcgggg ccccgagcag   4380

ctccccactc tgcccgtcca ccttccctgg ctccagcctc attctctctt tagtttaact   4440

atgcaaagag aggaggttga gagtgttctg gcagctggag ctcttttcct tgtccttcct   4500

gccctccgat ggggccacct gtgtcggggc agcagtgtcc atgtttatgg agatcagagg   4560

tgtccccact gtgtggctgg actgtactct gctgcccggg tagccaggag tctctccctc   4620

tctcccctgc cgcctgcctg gtctcatggg cctccttcac acacccctcc ctgtggatcg   4680

cctgcctggg cccagagcag gggaactgga gtttgtgagt gagcagagca ggttatgtgc   4740

agacagggaa acgagaactt tggacctggc tttctgagtc caggtgagag ctgtgtggcc   4800

ccccgatgcc actctgcccg ccggagggat gtgcctgctg agccttttcc ttccacgccg   4860

cctctcactg ccaggccagc ggcttccgct gagactcgct ggagaggcgg ctcccgtgtc   4920

cgtccaccga gcactcagat ggatgctgat caccagggcc gagggggctc ccagaaggac   4980

cccaggccct ggggagggtg gctgtgggag gccaagtcca ctgcccggaa gtcttgtcag   5040

ccctaagcca gggaagcctg gagcgtggcc tggcgggtct gggtggacac cgtccccact   5100

ccggactccc agcacagggg aggatacctg agcctgtatg gccctgtagc cctgggcaga   5160

gctgggcctg tcgtgtgttc ctgcctggca ggtgcaggtg ctggccatct gcaggtggaa   5220

ggaggtggga atcttggatt ttttgttttt ttttgtcttt ttttttttga gatgaagtct   5280

cgctctgaca cccaggctgg cgtgcagtgg tgtgatctcg gctcactgca aactccgctt   5340

cctgggttca agtggttctc ctgccccagc ctcccaagta gctgggatta caggcatgcg   5400

ccaccacgct cagctgattt ttgtattttt agtagagatg gggtttcacc atgttggcca   5460

agctggtctc aaactcctga cctcaagtga tctgcccgcc tcggcctccc agagtgctgg   5520

gattacaggc gtgagccagt gcacccggcg gaatcttgga atttttatag acagcacctc   5580

agtttctgac tccagccgca cacctcctgc ctctgccagc aggggttgcc gccagaccag   5640

agccagggcc aggtccctgc gtccatcccc cccggtagga tggacgtgag ccatccttct   5700

aggggacttt tttcagtgtg cgactcgtct ctgttaggtg gtaggagcca gtttgtgtgg   5760

cctgtgccac gctccacagt gcgtggctgg gctctgtgtg tggcctgtgt cccctgtccc   5820

tgcaggaccc agcaggcatc gtggcgtgac agctgtgtcc aagccactgc ccgggcatcc   5880

catcacccac cagggtgcac ggtctctcct gctgggggct ttctgtcgca tgtgtgtctc   5940

ctgtcgactc tgcagtttgt tctcagagca gaatgtttcc tgttctcagt gcacaaagac   6000

actggttttc aatcggcgtc taaaaccacg ttcctgcctt tcattgcaac acggtgtgtt   6060

catttgttta aaacagttta atgagtaagt ttagatgact ggtcaatatc ttaaaaatgt   6120

atattagtaa gaagttcttc ctggaatttt tctttcgatt ctggcagaat aaacaggtgt   6180

ttttagtttt cccactgtct gagccaagca ggaccctgtc ccagagcaag agatgtcccc   6240

ttccatctct gacccttgcc tgggacaagc tttgatgggg ggccccagct tcaaggctgt   6300

ggtgggaaca gcacccccaa atgccagcct ctcctttctt cccatccacc agtatactgc   6360

ggggccattt ctggtctttg tccaacagga aacccatttc tggtgggata tgccttccag   6420

tgccacaggg ccactcaccc catgcatctc tgtcctgccc gtcagtgctg ggacggacag   6480

caagggcaag cccagtgtct ggcggatagg tgggtgggaa cagagagggg agaatgccgt   6540

cctaagcttc tgcttgggga tcccccacac gacctgggta ctgcctggga aacctgtcct   6600

aagtaaaact atggacctcg cctcgcccac cggcctgcga agccagcatc tccgtgaagg   6660

tggatggaag cgcctttgtc ctcattttga gctgcaagct gggtcagcgg ctctgaagcc   6720

ctcgagtgac tttctaaccc aagacccagc ccctggcagg aggagggtgg gtgcagggct   6780

ggtgggacaa aaagaggcct cagcaggcct ggaagaccct tccagtacat cccacagcgt   6840

gtcgagcagc tgggagaacc tgtgtcaagc tcgagccgtc ataggtcccc atgaggtgtc   6900

tgaagcccct tcttggtgat gggaggcaga ggtgctgacg ttctggagca tggacgtgag   6960

tcctcagctg gctccgcgtg ggcccttgga gggtgccagg tgtgtggtga ccttctggat   7020

gcctttaact tcatggctgc gtcattcctg atttagaact ttaaccggag cttcatctag   7080

tgattgcaaa actggaccaa tgggaggacg gcggcgcagc ccgctccctc cgtggaatgg   7140

agctcagctc ttcggaggca tcaaagcacc tgtcgcctcc gtggtccccc tgctgaggga   7200

gtgcggcctc tgcaaggttc gggggtggct tcgtttgcct ggagtggccg gccctgcttg   7260

tgccatgtgg atgtttgtga gcctcggtcc tacagcactg tgtaggctgc atctgtttcg   7320

tgctggtcct gttgacttgt atgatatcca caaataaata ttttcatggc ggtaaaaaaa   7380


<210>  1820
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  1820

Met Glu Glu Glu Cys Arg Val Leu Ser Ile Gln Ser His Val Ile Arg 
1               5                   10                  15      


Gly Tyr Val Gly Asn Arg Ala Ala Thr Phe Pro Leu Gln Val Leu Gly 
            20                  25                  30          


Phe Glu Ile Asp Ala Val Asn Ser Val Gln Phe Ser Asn His Thr Gly 
        35                  40                  45              


Tyr Ala His Trp Lys Gly Gln Val Leu Asn Ser Asp Glu Leu Gln Glu 
    50                  55                  60                  


Leu Tyr Glu Gly Leu Arg Leu Asn Asn Met Asn Lys Tyr Asp Tyr Val 
65                  70                  75                  80  


Leu Thr Gly Tyr Thr Arg Asp Lys Ser Phe Leu Ala Met Val Val Asp 
                85                  90                  95      


Ile Val Gln Glu Leu Lys Gln Gln Asn Pro Arg Leu Val Tyr Val Cys 
            100                 105                 110         


Asp Pro Val Leu Gly Asp Lys Trp Asp Gly Glu Gly Ser Met Tyr Val 
        115                 120                 125             


Pro Glu Asp Leu Leu Pro Val Tyr Lys Glu Lys Val Val Pro Leu Ala 
    130                 135                 140                 


Asp Ile Ile Thr Pro Asn Gln Phe Glu Ala Glu Leu Leu Ser Gly Arg 
145                 150                 155                 160 


Lys Ile His Ser Gln Glu Glu Ala Leu Arg Val Met Asp Met Leu His 
                165                 170                 175     


Ser Met Gly Pro Asp Thr Val Val Ile Thr Ser Ser Asp Leu Pro Ser 
            180                 185                 190         


Pro Gln Gly Ser Asn Tyr Leu Ile Val Leu Gly Ser Gln Arg Arg Arg 
        195                 200                 205             


Asn Pro Ala Gly Ser Val Val Met Glu Arg Ile Arg Met Asp Ile Arg 
    210                 215                 220                 


Lys Val Asp Ala Val Phe Val Gly Thr Gly Asp Leu Phe Ala Ala Met 
225                 230                 235                 240 


Leu Leu Ala Trp Thr His Lys His Pro Asn Asn Leu Lys Val Ala Cys 
                245                 250                 255     


Glu Lys Thr Val Ser Thr Leu His His Val Leu Gln Arg Thr Ile Gln 
            260                 265                 270         


Cys Ala Lys Ala Gln Ala Gly Glu Gly Val Arg Pro Ser Pro Met Gln 
        275                 280                 285             


Leu Glu Leu Arg Met Val Gln Ser Lys Arg Asp Ile Glu Asp Pro Glu 
    290                 295                 300                 


Ile Val Val Gln Ala Thr Val Leu 
305                 310         


<210>  1821
<211>  1989
<212>  DNA
<213>  Homosapiens

<400>  1821
cgcctgcagg ttttgggatt tgagattgac gcggtgaact ctgtccagtt ttcaaaccac     60

acagagacaa ggtcggtctc tgtcgcccag gctggcgtga agtggcgcaa ccagctcact    120

gcagccttga cctcctgggc tgaagcaatc tttctgcctc cacctcccga gtggctggga    180

ctatagttgt gcaccagcac gcccacctcc tgcccagggt tgttactggg gtggtcacgt    240

gggcagcttc tgcctgggat gggccacaaa gccagactcc cggcagggac acgggtgttc    300

cacacaagct gcgttgttgg ttccctgacg cccttcaggc tggggggtgg gaaagccgat    360

cccccaagtg cctgcagagc ccacctggcg caggcctcgc cgcctcgagg ctgctgctcg    420

cacttctgcc ccttcccccg gccaggcccc cgttccttga ggccgtacca caaggtgcgt    480

tcatttttcc acaccgtgag ctgggcttgg cagagcctcc accttgtggc cagtattccc    540

agtggcccct ttgagaggat ttcctggagc tccctgtctg agcttcccgg actgagggca    600

ctgggaagga gcctgcggag ctggaggtca gcgggtggac gggttgcgct gtcctggctt    660

tcggagtgta gagccagagg ggatgggaca ggtgccctgc tgctgggctt ggtggtccct    720

gctgcaggga aggggcagct ggtgtgaaca caaggagctg cggggctgga gaaggccagg    780

gccaggagcc tgccgacgga caccagcgag gggccaggcc gggccaggag cctgccgacg    840

gacaccagcg aggggccagg ccgggccaga ctccctggcc ggctgggatc tgacaggagc    900

gccaggctcc ttgggccgcc cgaggaaccg cttgtttgcc tgtgcttttt catctgtaaa    960

tggaatgagt tggacacaag atccaagcgc cctcccctgt tggagaaggt tcttgtgggc   1020

tctgggccca tcccacatcc cacagtgggc aggaggccac caagaggtgc aagaccatgc   1080

cctctgtttc gataggaagc tgggcctcag aggggcctgg ggcctgtgtc tgagacccgg   1140

ccaagtgctg gacgtctccc cttcctcatg gctgttatgg ctgaattacg tccccccaaa   1200

ttctcatgtt gcagccttaa ccccagcacc tcagtgtggg actgggtttg gagatggagc   1260

ccctacagag gtcagcaggt taaaagaggc catcagggct ctgggtgggc cctgatccaa   1320

gctgcttggt gtccttgtaa gaagaagaga tgaggacaca gacacacaca gagggacagc   1380

cccatgagga aacagggagg caatgccgtc tgcaagccca gggcagaggc ctcaggaacc   1440

agccctggtg acacctggac cttggacccc cgtgcccagg acagtaggag aattggagcc   1500

gcctggctgc agtccttccc gatggcaccc tgtattagtc cgttctcaca ctgctaattg   1560

ttgggaaaag ggcttgtgga atgcctgtat aaactggcca tgaaaatatg ggacaataag   1620

ttgtggaaag ccacaagagg cctctgagga ggaaagcctc ctaattgcca tcatgttcgc   1680

atgctcaggg cgagacctgc tgtcttatct gtaaacactg tgttcaagga gaaagacatt   1740

ccttcgaagc actggactgt ggacagacac acgagctcct ggttaagccc gctcccacca   1800

gctcctgtcc gataagttaa agatacgctg tttgagcaca aaggagattc attgaaaccg   1860

ctattgctgt agattacgcc tgtgacgcac tgcctccctt tcactgtttc gccctgaata   1920

tctgcttctc agatctaagt gactgtactc aataaatagc gtggagacca gaaaaaaaaa   1980

aaaaaaaaa                                                           1989


<210>  1822
<211>  162
<212>  PRT
<213>  Homosapiens

<400>  1822

Met Gly His Lys Ala Arg Leu Pro Ala Gly Thr Arg Val Phe His Thr 
1               5                   10                  15      


Ser Cys Val Val Gly Ser Leu Thr Pro Phe Arg Leu Gly Gly Gly Lys 
            20                  25                  30          


Ala Asp Pro Pro Ser Ala Cys Arg Ala His Leu Ala Gln Ala Ser Pro 
        35                  40                  45              


Pro Arg Gly Cys Cys Ser His Phe Cys Pro Phe Pro Arg Pro Gly Pro 
    50                  55                  60                  


Arg Ser Leu Arg Pro Tyr His Lys Val Arg Ser Phe Phe His Thr Val 
65                  70                  75                  80  


Ser Trp Ala Trp Gln Ser Leu His Leu Val Ala Ser Ile Pro Ser Gly 
                85                  90                  95      


Pro Phe Glu Arg Ile Ser Trp Ser Ser Leu Ser Glu Leu Pro Gly Leu 
            100                 105                 110         


Arg Ala Leu Gly Arg Ser Leu Arg Ser Trp Arg Ser Ala Gly Gly Arg 
        115                 120                 125             


Val Ala Leu Ser Trp Leu Ser Glu Cys Arg Ala Arg Gly Asp Gly Thr 
    130                 135                 140                 


Gly Ala Leu Leu Leu Gly Leu Val Val Pro Ala Ala Gly Lys Gly Gln 
145                 150                 155                 160 


Leu Val 
        


<210>  1823
<211>  3151
<212>  DNA
<213>  Homosapiens

<400>  1823
gtcctcgtgc gctgtggacg gaggttgtgg agagagcagg gcggcattgg tggctgcggc     60

tgaggcttga gccagagatt taaaaatgga caatgatgat tttttttcca tggactttaa    120

agatggagtc tgtctctgtt gtccaggctg gagtgcagtg gcatgatctc ggctcactgc    180

aacctccgcc tcctgtgttc aagcgattct tctgcctcag cctcccaagt agctgggact    240

acagaagttg ttgaaaacct ggttacaaat gataattcac ctaacatacc agaggcaatt    300

gatagactct tcagcgacat agcaaatatc aacagggagt ctatggctga aataacagac    360

attcagattg aagaaatggc agtaaaccta tggaactggg cacttaccat aggaggaggt    420

tggcttgtaa atgaagagca gaaaattaga ttacattatg ttgcttgcaa gttgctgagt    480

atgtgtgaag cctcatttgc ctcagaacaa agtattcaac gactgattat gatgaatatg    540

agaataggaa aagaatggtt ggatgctgga aattttctaa tcgctgatga atgttttcaa    600

gctgctgtgg ccagtctgga gcaattatac gtcaaattaa ttcaaaggag ctcccctgag    660

gctgacttga ccatggagaa gattactgtt gagagtgacc acttcagagt gctttcttac    720

caagcagagt cagcagttgc tcaaggggat tttcaaagag catctatgtg tgtactgcaa    780

tgtaaagata tgttgatgag gctcccccag atgacttcaa gtcttcatca tctctgttac    840

aactttggag tagaaaccca gaagaataat aaatatgaag aaagttcttt ctggcttagc    900

caaagctatg atattgggaa gatggataag aaatctactg ggccagaaat gctggctaaa    960

gttctacggc tattagccac gaattatttg gattgggatg acaccaaata ttatgataag   1020

gctctcaatg ctgtaaacct agcaaacaag gaacatttaa gttctcctgg gcttttctta   1080

aaaatgaaaa tcctcttgaa aggcgaaaca tctaatgaag aactccttga agctgtcatg   1140

gaaatactac atcttgacat gcccttagac ttctgtctga acattgctaa actgctgatg   1200

gatcatgaaa gagaatctgt tgggtttcat ttcctgacga ttattcatga acgttttaag   1260

tcatcggaaa atattggaaa agttctgata ctccatactg acatgctttt acaaaggaag   1320

gaagaacttc ttgccaagga gaagattgaa gaaatctttt tagctcacca aacaggaaga   1380

caactgacag cagaatcaat gaactggtta cacaacattc tgtggagaca agctgccagt   1440

agttttgagg tacaaaatta cactgatgcc ctacaatggt actattattc tctgaggttt   1500

tattcaactg atgaaatgga tctggacttc accaagctgc agaggaacat ggcttgctgt   1560

tacctgaatt tgcaacaact tgataaggcc aaagaggcag tggcagaagc tgaacgacat   1620

gaccctagga acgttttcac tcaattttat atattcaaga ttgcagtcat agagggcaac   1680

tctgaaagag ctttgcaggc aataattact ttagagaata tattaacaga tgaagagtca   1740

gaagataatg atctagttgc agagagaggt tcacctacca tgcttctaag tttagctgcc   1800

cagtttgctc tagagaatgg acaacaaatt gtggcagaaa aagctttgga atatttagct   1860

caacattcag aagaccagga acaagttctt acagctgtaa agtgtttgct tcgttttctt   1920

cttccaaaaa ttgctgaaat gccggaatct gaagataaga agaaagaaat ggatcgactt   1980

ttgacttgcc tgaatagagc ctttgtgaaa ctttctcagc cttttggtga agaagcctta   2040

agtttggagt caagagctaa tgaagctcag tggtttcgaa aaacagcttg gaacttggct   2100

gtgcaatgtg acaaagatcc agtgatgatg agagagtttt ttatactttc ttataagatg   2160

tcccagtttt gtccttctga tcaagtaatt ctgattgcac ggaaaacatg tttacttatg   2220

gcagttgcag ttgatctaga gcaagggaga aaagcttcaa cagcttttga acagaccatg   2280

ttcctgagtc gtgcacttga ggagatccag acatgcaatg acatccataa tttcctgaaa   2340

caaacaggga ccttctcaaa tgattcatgt gagaaattgc ttctgctgta cgagtttgaa   2400

gttagagcca aattgaatga tccattactg gaaagcttcc tggaatcagt gtgggagttg   2460

cctcatttag aaactaaaac ttttgaaaca attgcaataa tagcaatgga aaagcctgca   2520

cactatcctt tgattgctct caaggccttg aaaaaggctt tattgctcta caaaaaggaa   2580

gaaccaattg atatatcaca atacagcaaa tgtatgcaca acttggttaa cctctcagtg   2640

ccagatgggg cgtcgaatgt agagctctgt cccctggaag aagtttgggg ctattttgaa   2700

gatgctctga gccacattag ccgcactaaa gactacccag aaatggagat tctctggctg   2760

atggtcaagt cctggaatac cggagtactt atgtttagca ggagcaagta tgcatctgct   2820

gaaaagtggt gtggcctggc cttgcgtttc cttaaccacc ttacctcctt caaggaaagc   2880

tatgaaactc agatgaatat gctgtatagt cagcttgtgg aagcattgag taacaacaag   2940

ggcccagttt ttcatgaaca tggctactgg agcaagtcag attaggcaag ctcatggcca   3000

catgaagaag atacattgtc ccgagatgct gactgtttaa atttttgcca gagtttctct   3060

tgagcttttg tttctgtttg ctcagaccct gttttcatgt tgttgaataa actttctaaa   3120

ataaaagcat gctgaattta aaaaaaaaaa a                                  3151


<210>  1824
<211>  940
<212>  PRT
<213>  Homosapiens

<400>  1824

Met Ile Ser Ala His Cys Asn Leu Arg Leu Leu Cys Ser Ser Asp Ser 
1               5                   10                  15      


Ser Ala Ser Ala Ser Gln Val Ala Gly Thr Thr Glu Val Val Glu Asn 
            20                  25                  30          


Leu Val Thr Asn Asp Asn Ser Pro Asn Ile Pro Glu Ala Ile Asp Arg 
        35                  40                  45              


Leu Phe Ser Asp Ile Ala Asn Ile Asn Arg Glu Ser Met Ala Glu Ile 
    50                  55                  60                  


Thr Asp Ile Gln Ile Glu Glu Met Ala Val Asn Leu Trp Asn Trp Ala 
65                  70                  75                  80  


Leu Thr Ile Gly Gly Gly Trp Leu Val Asn Glu Glu Gln Lys Ile Arg 
                85                  90                  95      


Leu His Tyr Val Ala Cys Lys Leu Leu Ser Met Cys Glu Ala Ser Phe 
            100                 105                 110         


Ala Ser Glu Gln Ser Ile Gln Arg Leu Ile Met Met Asn Met Arg Ile 
        115                 120                 125             


Gly Lys Glu Trp Leu Asp Ala Gly Asn Phe Leu Ile Ala Asp Glu Cys 
    130                 135                 140                 


Phe Gln Ala Ala Val Ala Ser Leu Glu Gln Leu Tyr Val Lys Leu Ile 
145                 150                 155                 160 


Gln Arg Ser Ser Pro Glu Ala Asp Leu Thr Met Glu Lys Ile Thr Val 
                165                 170                 175     


Glu Ser Asp His Phe Arg Val Leu Ser Tyr Gln Ala Glu Ser Ala Val 
            180                 185                 190         


Ala Gln Gly Asp Phe Gln Arg Ala Ser Met Cys Val Leu Gln Cys Lys 
        195                 200                 205             


Asp Met Leu Met Arg Leu Pro Gln Met Thr Ser Ser Leu His His Leu 
    210                 215                 220                 


Cys Tyr Asn Phe Gly Val Glu Thr Gln Lys Asn Asn Lys Tyr Glu Glu 
225                 230                 235                 240 


Ser Ser Phe Trp Leu Ser Gln Ser Tyr Asp Ile Gly Lys Met Asp Lys 
                245                 250                 255     


Lys Ser Thr Gly Pro Glu Met Leu Ala Lys Val Leu Arg Leu Leu Ala 
            260                 265                 270         


Thr Asn Tyr Leu Asp Trp Asp Asp Thr Lys Tyr Tyr Asp Lys Ala Leu 
        275                 280                 285             


Asn Ala Val Asn Leu Ala Asn Lys Glu His Leu Ser Ser Pro Gly Leu 
    290                 295                 300                 


Phe Leu Lys Met Lys Ile Leu Leu Lys Gly Glu Thr Ser Asn Glu Glu 
305                 310                 315                 320 


Leu Leu Glu Ala Val Met Glu Ile Leu His Leu Asp Met Pro Leu Asp 
                325                 330                 335     


Phe Cys Leu Asn Ile Ala Lys Leu Leu Met Asp His Glu Arg Glu Ser 
            340                 345                 350         


Val Gly Phe His Phe Leu Thr Ile Ile His Glu Arg Phe Lys Ser Ser 
        355                 360                 365             


Glu Asn Ile Gly Lys Val Leu Ile Leu His Thr Asp Met Leu Leu Gln 
    370                 375                 380                 


Arg Lys Glu Glu Leu Leu Ala Lys Glu Lys Ile Glu Glu Ile Phe Leu 
385                 390                 395                 400 


Ala His Gln Thr Gly Arg Gln Leu Thr Ala Glu Ser Met Asn Trp Leu 
                405                 410                 415     


His Asn Ile Leu Trp Arg Gln Ala Ala Ser Ser Phe Glu Val Gln Asn 
            420                 425                 430         


Tyr Thr Asp Ala Leu Gln Trp Tyr Tyr Tyr Ser Leu Arg Phe Tyr Ser 
        435                 440                 445             


Thr Asp Glu Met Asp Leu Asp Phe Thr Lys Leu Gln Arg Asn Met Ala 
    450                 455                 460                 


Cys Cys Tyr Leu Asn Leu Gln Gln Leu Asp Lys Ala Lys Glu Ala Val 
465                 470                 475                 480 


Ala Glu Ala Glu Arg His Asp Pro Arg Asn Val Phe Thr Gln Phe Tyr 
                485                 490                 495     


Ile Phe Lys Ile Ala Val Ile Glu Gly Asn Ser Glu Arg Ala Leu Gln 
            500                 505                 510         


Ala Ile Ile Thr Leu Glu Asn Ile Leu Thr Asp Glu Glu Ser Glu Asp 
        515                 520                 525             


Asn Asp Leu Val Ala Glu Arg Gly Ser Pro Thr Met Leu Leu Ser Leu 
    530                 535                 540                 


Ala Ala Gln Phe Ala Leu Glu Asn Gly Gln Gln Ile Val Ala Glu Lys 
545                 550                 555                 560 


Ala Leu Glu Tyr Leu Ala Gln His Ser Glu Asp Gln Glu Gln Val Leu 
                565                 570                 575     


Thr Ala Val Lys Cys Leu Leu Arg Phe Leu Leu Pro Lys Ile Ala Glu 
            580                 585                 590         


Met Pro Glu Ser Glu Asp Lys Lys Lys Glu Met Asp Arg Leu Leu Thr 
        595                 600                 605             


Cys Leu Asn Arg Ala Phe Val Lys Leu Ser Gln Pro Phe Gly Glu Glu 
    610                 615                 620                 


Ala Leu Ser Leu Glu Ser Arg Ala Asn Glu Ala Gln Trp Phe Arg Lys 
625                 630                 635                 640 


Thr Ala Trp Asn Leu Ala Val Gln Cys Asp Lys Asp Pro Val Met Met 
                645                 650                 655     


Arg Glu Phe Phe Ile Leu Ser Tyr Lys Met Ser Gln Phe Cys Pro Ser 
            660                 665                 670         


Asp Gln Val Ile Leu Ile Ala Arg Lys Thr Cys Leu Leu Met Ala Val 
        675                 680                 685             


Ala Val Asp Leu Glu Gln Gly Arg Lys Ala Ser Thr Ala Phe Glu Gln 
    690                 695                 700                 


Thr Met Phe Leu Ser Arg Ala Leu Glu Glu Ile Gln Thr Cys Asn Asp 
705                 710                 715                 720 


Ile His Asn Phe Leu Lys Gln Thr Gly Thr Phe Ser Asn Asp Ser Cys 
                725                 730                 735     


Glu Lys Leu Leu Leu Leu Tyr Glu Phe Glu Val Arg Ala Lys Leu Asn 
            740                 745                 750         


Asp Pro Leu Leu Glu Ser Phe Leu Glu Ser Val Trp Glu Leu Pro His 
        755                 760                 765             


Leu Glu Thr Lys Thr Phe Glu Thr Ile Ala Ile Ile Ala Met Glu Lys 
    770                 775                 780                 


Pro Ala His Tyr Pro Leu Ile Ala Leu Lys Ala Leu Lys Lys Ala Leu 
785                 790                 795                 800 


Leu Leu Tyr Lys Lys Glu Glu Pro Ile Asp Ile Ser Gln Tyr Ser Lys 
                805                 810                 815     


Cys Met His Asn Leu Val Asn Leu Ser Val Pro Asp Gly Ala Ser Asn 
            820                 825                 830         


Val Glu Leu Cys Pro Leu Glu Glu Val Trp Gly Tyr Phe Glu Asp Ala 
        835                 840                 845             


Leu Ser His Ile Ser Arg Thr Lys Asp Tyr Pro Glu Met Glu Ile Leu 
    850                 855                 860                 


Trp Leu Met Val Lys Ser Trp Asn Thr Gly Val Leu Met Phe Ser Arg 
865                 870                 875                 880 


Ser Lys Tyr Ala Ser Ala Glu Lys Trp Cys Gly Leu Ala Leu Arg Phe 
                885                 890                 895     


Leu Asn His Leu Thr Ser Phe Lys Glu Ser Tyr Glu Thr Gln Met Asn 
            900                 905                 910         


Met Leu Tyr Ser Gln Leu Val Glu Ala Leu Ser Asn Asn Lys Gly Pro 
        915                 920                 925             


Val Phe His Glu His Gly Tyr Trp Ser Lys Ser Asp 
    930                 935                 940 


<210>  1825
<211>  3029
<212>  DNA
<213>  Homosapiens

<400>  1825
gtcctcgtgc gctgtggacg gaggttgtgg agagagcagg gcggcattgg tggctgcggc     60

tgaggcttga gccagagatt taaaaatgga caatgatgat tttttttcca tggactttaa    120

agaagttgtt gaaaacctgg ttacaaatga taattcacct aacataccag aggcaattga    180

tagactcttc agcgacatag caaatatcaa cagggagtct atggctgaaa taacagacat    240

tcagattgaa gaaatggcag taaacctatg gaactgggca cttaccatag gaggaggttg    300

gcttgtaaat gaagagcaga aaattagatt acattatgtt gcttgcaagt tgctgagtat    360

gtgtgaagcc tcatttgcct cagaacaaag tattcaacga ctgattatga tgaatatgag    420

aataggaaaa gaatggttgg atgctggaaa ttttctaatc gctgatgaat gttttcaagc    480

tgctgtggcc agtctggagc aattatacgt caaattaatt caaaggagct cccctgaggc    540

tgacttgacc atggagaaga ttactgttga gagtgaccac ttcagagtgc tttcttacca    600

agcagagtca gcagttgctc aaggggattt tcaaagagca tctatgtgtg tactgcaatg    660

taaagatatg ttgatgaggc tcccccagat gacttcaagt cttcatcatc tctgttacaa    720

ctttggagta gaaacccaga agaataataa atatgaagaa agttctttct ggcttagcca    780

aagctatgat attgggaaga tggataagaa atctactggg ccagaaatgc tggctaaagt    840

tctacggcta ttagccacga attatttgga ttgggatgac accaaatatt atgataaggc    900

tctcaatgct gtaaacctag caaacaagga acatttaagt tctcctgggc ttttcttaaa    960

aatgaaaatc ctcttgaaag gcgaaacatc taatgaagaa ctccttgaag ctgtcatgga   1020

aatactacat cttgacatgc ccttagactt ctgtctgaac attgctaaac tgctgatgga   1080

tcatgaaaga gaatctgttg ggtttcattt cctgacgatt attcatgaac gttttaagtc   1140

atcggaaaat attggaaaag ttctgatact ccatactgac atgcttttac aaaggaagga   1200

agaacttctt gccaaggaga agattgaaga aatcttttta gctcaccaaa caggaagaca   1260

actgacagca gaatcaatga actggttaca caacattctg tggagacaag ctgccagtag   1320

ttttgaggta caaaattaca ctgatgccct acaatggtac tattattctc tgaggtttta   1380

ttcaactgat gaaatggatc tggacttcac caagctgcag aggaacatgg cttgctgtta   1440

cctgaatttg caacaacttg ataaggccaa agaggcagtg gcagaagctg aacgacatga   1500

ccctaggaac gttttcactc aattttatat attcaagatt gcagtcatag agggcaactc   1560

tgaaagagct ttgcaggcaa taattacttt agagaatata ttaacagatg aagagtcaga   1620

agataatgat ctagttgcag agagaggttc acctaccatg cttctaagtt tagctgccca   1680

gtttgctcta gagaatggac aacaaattgt ggcagaaaaa gctttggaat atttagctca   1740

acattcagaa gaccaggaac aagttcttac agctgtaaag tgtttgcttc gttttcttct   1800

tccaaaaatt gctgaaatgc cggaatctga agataagaag aaagaaatgg atcgactttt   1860

gacttgcctg aatagagcct ttgtgaaact ttctcagcct tttggtgaag aagccttaag   1920

tttggagtca agagctaatg aagctcagtg gtttcgaaaa acagcttgga acttggctgt   1980

gcaatgtgac aaagatccag tgatgatgag agagtttttt atactttctt ataagatgtc   2040

ccagttttgt ccttctgatc aagtaattct gattgcacgg aaaacatgtt tacttatggc   2100

agttgcagtt gatctagagc aagggagaaa agcttcaaca gcttttgaac agaccatgtt   2160

cctgagtcgt gcacttgagg agatccagac atgcaatgac atccataatt tcctgaaaca   2220

aacagggacc ttctcaaatg attcatgtga gaaattgctt ctgctgtacg agtttgaagt   2280

tagagccaaa ttgaatgatc cattactgga aagcttcctg gaatcagtgt gggagttgcc   2340

tcatttagaa actaaaactt ttgaaacaat tgcaataata gcaatggaaa agcctgcaca   2400

ctatcctttg attgctctca aggccttgaa aaaggcttta ttgctctaca aaaaggaaga   2460

accaattgat atatcacaat acagcaaatg tatgcacaac ttggttaacc tctcagtgcc   2520

agatggggcg tcgaatgtag agctctgtcc cctggaagaa gtttggggct attttgaaga   2580

tgctctgagc cacattagcc gcactaaaga ctacccagaa atggagattc tctggctgat   2640

ggtcaagtcc tggaataccg gagtacttat gtttagcagg agcaagtatg catctgctga   2700

aaagtggtgt ggcctggcct tgcgtttcct taaccacctt acctccttca aggaaagcta   2760

tgaaactcag atgaatatgc tgtatagtca gcttgtggaa gcattgagta acaacaaggg   2820

cccagttttt catgaacatg gctactggag caagtcagat taggcaagct catggccaca   2880

tgaagaagat acattgtccc gagatgctga ctgtttaaat ttttgccaga gtttctcttg   2940

agcttttgtt tctgtttgct cagaccctgt tttcatgttg ttgaataaac tttctaaaat   3000

aaaagcatgc tgaatttaaa aaaaaaaaa                                     3029


<210>  1826
<211>  925
<212>  PRT
<213>  Homosapiens

<400>  1826

Met Asp Asn Asp Asp Phe Phe Ser Met Asp Phe Lys Glu Val Val Glu 
1               5                   10                  15      


Asn Leu Val Thr Asn Asp Asn Ser Pro Asn Ile Pro Glu Ala Ile Asp 
            20                  25                  30          


Arg Leu Phe Ser Asp Ile Ala Asn Ile Asn Arg Glu Ser Met Ala Glu 
        35                  40                  45              


Ile Thr Asp Ile Gln Ile Glu Glu Met Ala Val Asn Leu Trp Asn Trp 
    50                  55                  60                  


Ala Leu Thr Ile Gly Gly Gly Trp Leu Val Asn Glu Glu Gln Lys Ile 
65                  70                  75                  80  


Arg Leu His Tyr Val Ala Cys Lys Leu Leu Ser Met Cys Glu Ala Ser 
                85                  90                  95      


Phe Ala Ser Glu Gln Ser Ile Gln Arg Leu Ile Met Met Asn Met Arg 
            100                 105                 110         


Ile Gly Lys Glu Trp Leu Asp Ala Gly Asn Phe Leu Ile Ala Asp Glu 
        115                 120                 125             


Cys Phe Gln Ala Ala Val Ala Ser Leu Glu Gln Leu Tyr Val Lys Leu 
    130                 135                 140                 


Ile Gln Arg Ser Ser Pro Glu Ala Asp Leu Thr Met Glu Lys Ile Thr 
145                 150                 155                 160 


Val Glu Ser Asp His Phe Arg Val Leu Ser Tyr Gln Ala Glu Ser Ala 
                165                 170                 175     


Val Ala Gln Gly Asp Phe Gln Arg Ala Ser Met Cys Val Leu Gln Cys 
            180                 185                 190         


Lys Asp Met Leu Met Arg Leu Pro Gln Met Thr Ser Ser Leu His His 
        195                 200                 205             


Leu Cys Tyr Asn Phe Gly Val Glu Thr Gln Lys Asn Asn Lys Tyr Glu 
    210                 215                 220                 


Glu Ser Ser Phe Trp Leu Ser Gln Ser Tyr Asp Ile Gly Lys Met Asp 
225                 230                 235                 240 


Lys Lys Ser Thr Gly Pro Glu Met Leu Ala Lys Val Leu Arg Leu Leu 
                245                 250                 255     


Ala Thr Asn Tyr Leu Asp Trp Asp Asp Thr Lys Tyr Tyr Asp Lys Ala 
            260                 265                 270         


Leu Asn Ala Val Asn Leu Ala Asn Lys Glu His Leu Ser Ser Pro Gly 
        275                 280                 285             


Leu Phe Leu Lys Met Lys Ile Leu Leu Lys Gly Glu Thr Ser Asn Glu 
    290                 295                 300                 


Glu Leu Leu Glu Ala Val Met Glu Ile Leu His Leu Asp Met Pro Leu 
305                 310                 315                 320 


Asp Phe Cys Leu Asn Ile Ala Lys Leu Leu Met Asp His Glu Arg Glu 
                325                 330                 335     


Ser Val Gly Phe His Phe Leu Thr Ile Ile His Glu Arg Phe Lys Ser 
            340                 345                 350         


Ser Glu Asn Ile Gly Lys Val Leu Ile Leu His Thr Asp Met Leu Leu 
        355                 360                 365             


Gln Arg Lys Glu Glu Leu Leu Ala Lys Glu Lys Ile Glu Glu Ile Phe 
    370                 375                 380                 


Leu Ala His Gln Thr Gly Arg Gln Leu Thr Ala Glu Ser Met Asn Trp 
385                 390                 395                 400 


Leu His Asn Ile Leu Trp Arg Gln Ala Ala Ser Ser Phe Glu Val Gln 
                405                 410                 415     


Asn Tyr Thr Asp Ala Leu Gln Trp Tyr Tyr Tyr Ser Leu Arg Phe Tyr 
            420                 425                 430         


Ser Thr Asp Glu Met Asp Leu Asp Phe Thr Lys Leu Gln Arg Asn Met 
        435                 440                 445             


Ala Cys Cys Tyr Leu Asn Leu Gln Gln Leu Asp Lys Ala Lys Glu Ala 
    450                 455                 460                 


Val Ala Glu Ala Glu Arg His Asp Pro Arg Asn Val Phe Thr Gln Phe 
465                 470                 475                 480 


Tyr Ile Phe Lys Ile Ala Val Ile Glu Gly Asn Ser Glu Arg Ala Leu 
                485                 490                 495     


Gln Ala Ile Ile Thr Leu Glu Asn Ile Leu Thr Asp Glu Glu Ser Glu 
            500                 505                 510         


Asp Asn Asp Leu Val Ala Glu Arg Gly Ser Pro Thr Met Leu Leu Ser 
        515                 520                 525             


Leu Ala Ala Gln Phe Ala Leu Glu Asn Gly Gln Gln Ile Val Ala Glu 
    530                 535                 540                 


Lys Ala Leu Glu Tyr Leu Ala Gln His Ser Glu Asp Gln Glu Gln Val 
545                 550                 555                 560 


Leu Thr Ala Val Lys Cys Leu Leu Arg Phe Leu Leu Pro Lys Ile Ala 
                565                 570                 575     


Glu Met Pro Glu Ser Glu Asp Lys Lys Lys Glu Met Asp Arg Leu Leu 
            580                 585                 590         


Thr Cys Leu Asn Arg Ala Phe Val Lys Leu Ser Gln Pro Phe Gly Glu 
        595                 600                 605             


Glu Ala Leu Ser Leu Glu Ser Arg Ala Asn Glu Ala Gln Trp Phe Arg 
    610                 615                 620                 


Lys Thr Ala Trp Asn Leu Ala Val Gln Cys Asp Lys Asp Pro Val Met 
625                 630                 635                 640 


Met Arg Glu Phe Phe Ile Leu Ser Tyr Lys Met Ser Gln Phe Cys Pro 
                645                 650                 655     


Ser Asp Gln Val Ile Leu Ile Ala Arg Lys Thr Cys Leu Leu Met Ala 
            660                 665                 670         


Val Ala Val Asp Leu Glu Gln Gly Arg Lys Ala Ser Thr Ala Phe Glu 
        675                 680                 685             


Gln Thr Met Phe Leu Ser Arg Ala Leu Glu Glu Ile Gln Thr Cys Asn 
    690                 695                 700                 


Asp Ile His Asn Phe Leu Lys Gln Thr Gly Thr Phe Ser Asn Asp Ser 
705                 710                 715                 720 


Cys Glu Lys Leu Leu Leu Leu Tyr Glu Phe Glu Val Arg Ala Lys Leu 
                725                 730                 735     


Asn Asp Pro Leu Leu Glu Ser Phe Leu Glu Ser Val Trp Glu Leu Pro 
            740                 745                 750         


His Leu Glu Thr Lys Thr Phe Glu Thr Ile Ala Ile Ile Ala Met Glu 
        755                 760                 765             


Lys Pro Ala His Tyr Pro Leu Ile Ala Leu Lys Ala Leu Lys Lys Ala 
    770                 775                 780                 


Leu Leu Leu Tyr Lys Lys Glu Glu Pro Ile Asp Ile Ser Gln Tyr Ser 
785                 790                 795                 800 


Lys Cys Met His Asn Leu Val Asn Leu Ser Val Pro Asp Gly Ala Ser 
                805                 810                 815     


Asn Val Glu Leu Cys Pro Leu Glu Glu Val Trp Gly Tyr Phe Glu Asp 
            820                 825                 830         


Ala Leu Ser His Ile Ser Arg Thr Lys Asp Tyr Pro Glu Met Glu Ile 
        835                 840                 845             


Leu Trp Leu Met Val Lys Ser Trp Asn Thr Gly Val Leu Met Phe Ser 
    850                 855                 860                 


Arg Ser Lys Tyr Ala Ser Ala Glu Lys Trp Cys Gly Leu Ala Leu Arg 
865                 870                 875                 880 


Phe Leu Asn His Leu Thr Ser Phe Lys Glu Ser Tyr Glu Thr Gln Met 
                885                 890                 895     


Asn Met Leu Tyr Ser Gln Leu Val Glu Ala Leu Ser Asn Asn Lys Gly 
            900                 905                 910         


Pro Val Phe His Glu His Gly Tyr Trp Ser Lys Ser Asp 
        915                 920                 925 


<210>  1827
<211>  2280
<212>  DNA
<213>  Homosapiens

<400>  1827
gcctgagcgg ccgaactcgg cagctccaac ccaactcggc ttaactccgc ctcaccgagc     60

ccagtccaag actctgtgct ccctaggttt gcaacagctc tctgatcatc ttcttcaatt    120

cctgctagga tgccgtggca agcatttcgc agatttggtc aaaagctggt acgcagacgt    180

acactggagt caggcatggc tgagactcgc cttgccagat gcctaagcac cctggattta    240

gtggccctgg gtgtgggcag cacattgggt gcaggcgtgt atgtcctagc tggcgaggtg    300

gccaaagata aagcagggcc atccattgtg atctgctttt tggtggctgc cctgtcttct    360

gtgttggctg ggctgtgcta tgcggagttt ggtgcccggg ttccccgttc tggttcggca    420

tatctctaca gctatgtcac tgtgggtgaa ctctgggcct tcaccactgg ctggaacctc    480

atcctctcct atgtcattgg tacagccagt gtggcccggg cctggagctc tgcttttgac    540

aacctgattg ggaaccacat ctctaagact ctgcaggggt ccattgcact gcacgtgccc    600

catgtccttg cagaatatcc agatttcttt gctttgggcc tcgtgttgct gctcactgga    660

ttgttggctc tcggggctag tgagtcggcc ctggttacca gagtgttcac aggcgtgaac    720

cttttggttc ttgggttcgt catgatctct ggcttcgtta agggggacgt gcacaactgg    780

aagctcacag aagaggacta cgaattggcc atggctgaac tcaatgacac ctatagcttg    840

ggtcctctgg gctctggagg atttgtgcct ttcggcttcg agggaattct ccgtggagca    900

gcgacctgtt tctatgcatt tgttggtttc gactgtattg ctaccactgg agaagaagcc    960

cagaatcccc agcgttccat cccgatgggc attgtgatct cactgtctgt ctgctttttg   1020

gcgtattttg ctgtctcttc tgcactcacc ctgatgatgc cttactacca gcttcagcct   1080

gagagccctt tgcctgaggc atttctctac attggatggg ctcctgcccg ctatgttgtg   1140

gctgttggct ccctctgtgc tctttctacc agcctcctgg gctccatgtt ccccatgcct   1200

cgggtgatct acgcgatggc agaggatggc ctcctgttcc gtgtacttgc tcggatccac   1260

accggcacac gcaccccaat catagccacc gtggtctctg gcattattgc agcattcatg   1320

gcattcctct tcaaactcac tgatcttgtg gacctcatgt caattgggac cctgcttgct   1380

tactccctgg tgtcgatttg tgttctcatc ctcaggtatc aacctgatca ggagacaaag   1440

actggggaag aagtggagtt gcaggaggag gcaataacta ctgaatcaga gaagttgacc   1500

ctatggggac tatttttccc actcaactcc atccccactc cactctctgg ccaaattgtc   1560

tatgtttgtt cctcattgct tgctgtcctg ctgactgctc tttgcctggt gctggcccag   1620

tggtcagttc cattgctttc tggagacctg gtgtggactg cagtggttgt gctgctcctg   1680

ctgctcatta ttgggatcat tgtggtcatc tggagacagc cacagagctc cactcccctt   1740

cactttaagg tgcctgcttt gcctctcctc ccactaatga gcatctttgt gaatatttac   1800

cttatgatgc agatgacagc tggtacctgg gcccgatttg gggtctggat gctgattggc   1860

tttgctatct acttcggcta tgggatccag cacagcctgg aagagattaa gagtaaccaa   1920

ccctcacgca agtctagagc caaaactgta gaccttgatc ccggcactct ctatgtccac   1980

tcagtttgac atcgtcacac ctaaatgctg tctggtcccc tgcacaataa tggagagtac   2040

tcctgacccc agtgacagct agccctcccc tgtgatggtg gtggtggata ctaatacagt   2100

tctgtacgat gtgaaggatg tgtctttgct atttcttgtc tattttaacc cgtctgcttc   2160

taaatgatgt ctagctgctt accaacttta aaaaatgata ttaaaagaaa gtagaaaaat   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2280


<210>  1828
<211>  619
<212>  PRT
<213>  Homosapiens

<400>  1828

Met Pro Trp Gln Ala Phe Arg Arg Phe Gly Gln Lys Leu Val Arg Arg 
1               5                   10                  15      


Arg Thr Leu Glu Ser Gly Met Ala Glu Thr Arg Leu Ala Arg Cys Leu 
            20                  25                  30          


Ser Thr Leu Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              


Gly Val Tyr Val Leu Ala Gly Glu Val Ala Lys Asp Lys Ala Gly Pro 
    50                  55                  60                  


Ser Ile Val Ile Cys Phe Leu Val Ala Ala Leu Ser Ser Val Leu Ala 
65                  70                  75                  80  


Gly Leu Cys Tyr Ala Glu Phe Gly Ala Arg Val Pro Arg Ser Gly Ser 
                85                  90                  95      


Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Thr 
            100                 105                 110         


Thr Gly Trp Asn Leu Ile Leu Ser Tyr Val Ile Gly Thr Ala Ser Val 
        115                 120                 125             


Ala Arg Ala Trp Ser Ser Ala Phe Asp Asn Leu Ile Gly Asn His Ile 
    130                 135                 140                 


Ser Lys Thr Leu Gln Gly Ser Ile Ala Leu His Val Pro His Val Leu 
145                 150                 155                 160 


Ala Glu Tyr Pro Asp Phe Phe Ala Leu Gly Leu Val Leu Leu Leu Thr 
                165                 170                 175     


Gly Leu Leu Ala Leu Gly Ala Ser Glu Ser Ala Leu Val Thr Arg Val 
            180                 185                 190         


Phe Thr Gly Val Asn Leu Leu Val Leu Gly Phe Val Met Ile Ser Gly 
        195                 200                 205             


Phe Val Lys Gly Asp Val His Asn Trp Lys Leu Thr Glu Glu Asp Tyr 
    210                 215                 220                 


Glu Leu Ala Met Ala Glu Leu Asn Asp Thr Tyr Ser Leu Gly Pro Leu 
225                 230                 235                 240 


Gly Ser Gly Gly Phe Val Pro Phe Gly Phe Glu Gly Ile Leu Arg Gly 
                245                 250                 255     


Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr 
            260                 265                 270         


Thr Gly Glu Glu Ala Gln Asn Pro Gln Arg Ser Ile Pro Met Gly Ile 
        275                 280                 285             


Val Ile Ser Leu Ser Val Cys Phe Leu Ala Tyr Phe Ala Val Ser Ser 
    290                 295                 300                 


Ala Leu Thr Leu Met Met Pro Tyr Tyr Gln Leu Gln Pro Glu Ser Pro 
305                 310                 315                 320 


Leu Pro Glu Ala Phe Leu Tyr Ile Gly Trp Ala Pro Ala Arg Tyr Val 
                325                 330                 335     


Val Ala Val Gly Ser Leu Cys Ala Leu Ser Thr Ser Leu Leu Gly Ser 
            340                 345                 350         


Met Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu 
        355                 360                 365             


Leu Phe Arg Val Leu Ala Arg Ile His Thr Gly Thr Arg Thr Pro Ile 
    370                 375                 380                 


Ile Ala Thr Val Val Ser Gly Ile Ile Ala Ala Phe Met Ala Phe Leu 
385                 390                 395                 400 


Phe Lys Leu Thr Asp Leu Val Asp Leu Met Ser Ile Gly Thr Leu Leu 
                405                 410                 415     


Ala Tyr Ser Leu Val Ser Ile Cys Val Leu Ile Leu Arg Tyr Gln Pro 
            420                 425                 430         


Asp Gln Glu Thr Lys Thr Gly Glu Glu Val Glu Leu Gln Glu Glu Ala 
        435                 440                 445             


Ile Thr Thr Glu Ser Glu Lys Leu Thr Leu Trp Gly Leu Phe Phe Pro 
    450                 455                 460                 


Leu Asn Ser Ile Pro Thr Pro Leu Ser Gly Gln Ile Val Tyr Val Cys 
465                 470                 475                 480 


Ser Ser Leu Leu Ala Val Leu Leu Thr Ala Leu Cys Leu Val Leu Ala 
                485                 490                 495     


Gln Trp Ser Val Pro Leu Leu Ser Gly Asp Leu Val Trp Thr Ala Val 
            500                 505                 510         


Val Val Leu Leu Leu Leu Leu Ile Ile Gly Ile Ile Val Val Ile Trp 
        515                 520                 525             


Arg Gln Pro Gln Ser Ser Thr Pro Leu His Phe Lys Val Pro Ala Leu 
    530                 535                 540                 


Pro Leu Leu Pro Leu Met Ser Ile Phe Val Asn Ile Tyr Leu Met Met 
545                 550                 555                 560 


Gln Met Thr Ala Gly Thr Trp Ala Arg Phe Gly Val Trp Met Leu Ile 
                565                 570                 575     


Gly Phe Ala Ile Tyr Phe Gly Tyr Gly Ile Gln His Ser Leu Glu Glu 
            580                 585                 590         


Ile Lys Ser Asn Gln Pro Ser Arg Lys Ser Arg Ala Lys Thr Val Asp 
        595                 600                 605             


Leu Asp Pro Gly Thr Leu Tyr Val His Ser Val 
    610                 615                 


<210>  1829
<211>  3521
<212>  DNA
<213>  Homosapiens

<400>  1829
aggaagcggg aagttactta gcacggttcc gggtttctcg cgccccgcct gtcccccctc     60

cctatcactg ctactggctc ttggtccctc cgttggactg tcctgcggag agaaacccca    120

gcccatcggt ctgcgctggg accgcccgcc gcgcatctgc ccttcttcgc tgactccgcc    180

ccgcatctgg ccagacccgc ctcgcgtcag agctgaccca ctcactgcgc gtttgccagt    240

cagtctctcc ggacctgcct cgagcctcag gctgctgaaa tcaccgcgcc tcactcgcct    300

cgacagtgat tctgagtctg cttttagctt ccttttgcct gccttggctt tttctgttcg    360

tgaacagctg tttggcccat agcttagaga aagcagcctt ttttctcttc aaagagaacc    420

tcctcccagt gctcagagag atggggagcg gggagcctaa tcctgctggc aagaaaaaga    480

agtatctcaa ggccgctctg tacgtgggtg acttggaccc agatgtcacc gaggacatgc    540

tctataagaa gttcaggcct gctggccctc tgcgattcac ccgaatctgc cgtgatccgg    600

tgacccgcag ccccctgggc tatgggtatg ttaacttccg ctttcccgcg gatgcagagt    660

gggccttgaa caccatgaat tttgatttga ttaatggaaa accattccgc cttatgtggt    720

ctcagccaga tgaccgctta agaaagtctg gagtgggaaa tatattcatc aaaaacctgg    780

acaaatccat agacaatagg gccctgtttt acttattttc tgcttttggg aacattctgt    840

cctgcaaagt cgtatgcgat gacaacggct ctaagggtta tgcctatgtt cactttgaca    900

gcctggccgc tgccaataga gccatctggc acatgaatgg agtgcggctc aacaaccgcc    960

aggtgtatgt tggcagattc aaattcccag aagagcgggc ggctgaggtc agaaccaggg   1020

atagagcaac tttcaccaat gttttcgtta aaaacattgg agacgacata gatgacgaaa   1080

aactgaagga acttttctgt gaatatgggc caactgagag tgttaaagta ataagagatg   1140

ccagtgggaa atctaaaggc tttggatttg tgagatatga gacacacgag gctgcccaaa   1200

aggctgtgct agacttgcat ggaaagtcca tcgatggaaa agtcctctat gtagggcgag   1260

cacagaagaa aattgaacgc ctggctgagt tgaggcggag atttgaacgg ctgaggttaa   1320

aagaaaaaag tcggccccca ggggtgccta tctatattaa gaacttggat gagacaatca   1380

atgatgaaaa actgaaggag gaattttctt cctttgggtc aattagtcgg gccaaagtga   1440

tgatggaagt ggggcaaggc aaaggatttg gtgtggtctg cttttcctct tttgaagagg   1500

ctaccaaagc agtggatgag atgaatggcc gcatagtggg ctccaagccc ctgcatgtca   1560

ccctgggcca ggccaggcgc aggtgctgag aataagaatg ctcagtttgt ttcagcctta   1620

gttggtgcct ccttagtttg ggctcctttg tgataagggg ttattttatg ctaattcaca   1680

agtttttttt gaagtgaatt cttttgaaaa aaaaatgcaa aactagaaaa ctttattcat   1740

tttagaatag aacataattt ctaactgtaa aattgtcatt ttgtactttt tttgatgtaa   1800

tatccttaga aatctgtaga ataaagtgta ttcctccact tttttttcct gaacagtcaa   1860

ggtgaggcaa ttgattgagt atatttccct tcttatttca gtaatactct attttttttc   1920

atgaaaatgt caacatggtt cttctgaatc tatcacagtg aaaagttcta acttgttttt   1980

gagaagtcag tacagcaggg gaaaacatat gtgatgcaat taacatctgc ataatttcac   2040

ttaaaattat tatgcaaaaa tgaatgtttt ttcaaaaaat gtgaaatgta ttttattttc   2100

tttatttgta ttcttgtttc attttttaat atgttgtgaa catgctacag atttgatagt   2160

acttttgact aaatgttggg agtggtcgta ttaacttctt gcccaaagaa gtaagcatat   2220

tggtgttttc tcaattagtc actgagaaaa ttaacacttt aggcagtggc tatttaaagt   2280

aggaattgca tcttaaaaac ctttcctaag agatttggta tgtgaggata ctttcagtac   2340

cactcctacc attcattttt ctaaattcct tagtacatat acttggatca tgttaaatta   2400

acaagaaaga tgaataactg cgctgaattg cctttaccta taaataattt aatattttac   2460

cttcgggttt tatcaactgt caatataaaa ggcagtactc cacagaatga tgttgaaaaa   2520

cttcttcgaa gaacaccttc tattaaactt gttatctctt gtaaattatt gtgtgtgtcc   2580

ttttgataat attcacaggt gtttcaaagg taaggaatag gttgtctctt ggattaagtc   2640

atatgcctcc agccattata tgagaactgt gaaaccaata tggttttctt tatgtcttgg   2700

ctgcttgaaa attaaaaaaa aaaaaggttt gttcaatatt gccgttacat ttattagcct   2760

gtaatttcta aattggagat tctctacatt tcacttgcag tttcctgttc tcctcattgc   2820

ctgccttcca ttcatattac acttattttt ctattttttg tattaccttt ttaaaaatat   2880

ataccagttc aagtcctttt aggaagaaga aaatacctaa tttatgtaaa atttaaataa   2940

ttactttttt ataatatgat tcacttatgc cacagattca acattagaat atgttttatc   3000

tctactgtca gttttattac cttatataca aatcttcatt ttcatacata gtacaatgta   3060

aatatataac tttgttaaca cttttgttag ctctttgacc ataaaataat gacaataagc   3120

tgtttctatg tatttgttta tctacaaatt acaggtttat ccatttgcaa atattttcaa   3180

aatggaaatc actgtttata ttgattataa acataagaca tgctcattgt aaaaaatgta   3240

cacaaggcag aaggaagtaa aatttccaca gttcagaaat accacaatta atattttcaa   3300

tgtgtaaata tcttttcata ttttttccta cgtatacaca aacattttga ccaaaaatcc   3360

acactatatg tactgttctg tatttttaat tttaaactga acaataatca tcttttcctg   3420

acaataaata tcaatctcta tcatcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       3521


<210>  1830
<211>  382
<212>  PRT
<213>  Homosapiens

<400>  1830

Met Gly Ser Gly Glu Pro Asn Pro Ala Gly Lys Lys Lys Lys Tyr Leu 
1               5                   10                  15      


Lys Ala Ala Leu Tyr Val Gly Asp Leu Asp Pro Asp Val Thr Glu Asp 
            20                  25                  30          


Met Leu Tyr Lys Lys Phe Arg Pro Ala Gly Pro Leu Arg Phe Thr Arg 
        35                  40                  45              


Ile Cys Arg Asp Pro Val Thr Arg Ser Pro Leu Gly Tyr Gly Tyr Val 
    50                  55                  60                  


Asn Phe Arg Phe Pro Ala Asp Ala Glu Trp Ala Leu Asn Thr Met Asn 
65                  70                  75                  80  


Phe Asp Leu Ile Asn Gly Lys Pro Phe Arg Leu Met Trp Ser Gln Pro 
                85                  90                  95      


Asp Asp Arg Leu Arg Lys Ser Gly Val Gly Asn Ile Phe Ile Lys Asn 
            100                 105                 110         


Leu Asp Lys Ser Ile Asp Asn Arg Ala Leu Phe Tyr Leu Phe Ser Ala 
        115                 120                 125             


Phe Gly Asn Ile Leu Ser Cys Lys Val Val Cys Asp Asp Asn Gly Ser 
    130                 135                 140                 


Lys Gly Tyr Ala Tyr Val His Phe Asp Ser Leu Ala Ala Ala Asn Arg 
145                 150                 155                 160 


Ala Ile Trp His Met Asn Gly Val Arg Leu Asn Asn Arg Gln Val Tyr 
                165                 170                 175     


Val Gly Arg Phe Lys Phe Pro Glu Glu Arg Ala Ala Glu Val Arg Thr 
            180                 185                 190         


Arg Asp Arg Ala Thr Phe Thr Asn Val Phe Val Lys Asn Ile Gly Asp 
        195                 200                 205             


Asp Ile Asp Asp Glu Lys Leu Lys Glu Leu Phe Cys Glu Tyr Gly Pro 
    210                 215                 220                 


Thr Glu Ser Val Lys Val Ile Arg Asp Ala Ser Gly Lys Ser Lys Gly 
225                 230                 235                 240 


Phe Gly Phe Val Arg Tyr Glu Thr His Glu Ala Ala Gln Lys Ala Val 
                245                 250                 255     


Leu Asp Leu His Gly Lys Ser Ile Asp Gly Lys Val Leu Tyr Val Gly 
            260                 265                 270         


Arg Ala Gln Lys Lys Ile Glu Arg Leu Ala Glu Leu Arg Arg Arg Phe 
        275                 280                 285             


Glu Arg Leu Arg Leu Lys Glu Lys Ser Arg Pro Pro Gly Val Pro Ile 
    290                 295                 300                 


Tyr Ile Lys Asn Leu Asp Glu Thr Ile Asn Asp Glu Lys Leu Lys Glu 
305                 310                 315                 320 


Glu Phe Ser Ser Phe Gly Ser Ile Ser Arg Ala Lys Val Met Met Glu 
                325                 330                 335     


Val Gly Gln Gly Lys Gly Phe Gly Val Val Cys Phe Ser Ser Phe Glu 
            340                 345                 350         


Glu Ala Thr Lys Ala Val Asp Glu Met Asn Gly Arg Ile Val Gly Ser 
        355                 360                 365             


Lys Pro Leu His Val Thr Leu Gly Gln Ala Arg Arg Arg Cys 
    370                 375                 380         


<210>  1831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1831
aaatatttac raagctcaca t                                               21


<210>  1832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1832
agtccctaga waatgatgac a                                               21


<210>  1833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1833
ctggccatgc ractgttctg c                                               21


<210>  1834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1834
gcagaaaaaa wtagtttagc t                                               21


<210>  1835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1835
acagaaatgc yaaaggaaac c                                               21


<210>  1836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1836
caaagagctc rttttagtat g                                               21


<210>  1837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1837
gggcccatca wgggagatat t                                               21


<210>  1838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1838
ttttggttaa mctttttttg c                                               21


<210>  1839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1839
aggttaccaa wtacttggca t                                               21


<210>  1840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1840
taaaaataga rtgagccaac c                                               21


<210>  1841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1841
agatactgct ycatttcttg t                                               21


<210>  1842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1842
ggtctcttta yaggctggct a                                               21


<210>  1843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1843
acattatttg ratgaaacat a                                               21


<210>  1844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1844
tctccaggat rttttcactc t                                               21


<210>  1845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1845
cttctaatgg ygcatttaca c                                               21


<210>  1846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1846
tgtgtatgtc rctgtaatta a                                               21


<210>  1847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1847
accaaactct yagaatgagc a                                               21


<210>  1848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1848
tgttttactt sagtggttct t                                               21


<210>  1849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1849
tcacaggtga ygtagaggag g                                               21


<210>  1850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1850
aaaagtccaa ygaactacag a                                               21


<210>  1851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1851
cggactcttg rcttcaggcg a                                               21


<210>  1852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1852
atgtccagcc rttagccaga a                                               21


<210>  1853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1853
ttccaacttc rtctcaactc c                                               21


<210>  1854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1854
tagtcaaata ragggctcct t                                               21


<210>  1855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1855
aagatgccca ytgccaagtc c                                               21


<210>  1856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1856
cattacaaaa yttttaacag c                                               21


<210>  1857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1857
ttaacgaaat ygtattttta a                                               21


<210>  1858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1858
ctttttgctt yacttcactg t                                               21


<210>  1859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1859
ctggagcttg rgcggcagag t                                               21


<210>  1860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1860
acatctgctt rccttcttta t                                               21


<210>  1861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1861
aacccataca sagagtttag a                                               21


<210>  1862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1862
agcactgact ktgagtcaca c                                               21


<210>  1863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1863
ctcatgcctg statttgatc t                                               21


<210>  1864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1864
gggagcccct mcgcaacaac c                                               21


<210>  1865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1865
caatattaat rttaaactgc c                                               21


<210>  1866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1866
tatccaagat raaattgtga c                                               21


<210>  1867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1867
acttttcagt stctttctcc a                                               21


<210>  1868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1868
ctcattagta ratcctgagt a                                               21


<210>  1869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1869
ctgtgcttca rtgcctttat a                                               21


<210>  1870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1870
tttaccaatg yggtggtggc c                                               21


<210>  1871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1871
ctatgattta raaaattgtg t                                               21


<210>  1872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1872
aaataatgag sgttcataag a                                               21


<210>  1873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1873
aaccagacca mgtacaggtg t                                               21


<210>  1874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1874
tcggctgctg waggtatttt g                                               21


<210>  1875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1875
ggaaaggaat rtattcagat g                                               21


<210>  1876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1876
ccagccaatt kaaagcaatt t                                               21


<210>  1877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1877
tttgtccact rcaaaaaaac a                                               21


<210>  1878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1878
tttcctcttc stgttatggt c                                               21


<210>  1879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1879
acaatcagta yggcaggaac a                                               21


<210>  1880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1880
tacaattcaa ytagagattt g                                               21


<210>  1881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1881
gctaagagat matcttaaca a                                               21


<210>  1882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1882
gaccattctt yttttcagga g                                               21


<210>  1883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1883
aagcaataga stagttcttc a                                               21


<210>  1884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1884
tgtttttgct rtaatcttca g                                               21


<210>  1885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1885
caggtgcaat rtgctgtgtc a                                               21


<210>  1886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1886
tctcattcac rcataatatc t                                               21


<210>  1887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1887
aacagagaaa rgtttgtctc t                                               21


<210>  1888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1888
aggtaataga satggtcatt c                                               21


<210>  1889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1889
taggacaata ytcattttag t                                               21


<210>  1890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1890
tatcagggac ytgagacttt g                                               21


<210>  1891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1891
ccgaacatca rcatttagga c                                               21


<210>  1892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1892
atgatatttc rgtgtaattg t                                               21


<210>  1893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1893
agaacattga rtctgaaatg t                                               21


<210>  1894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1894
acaataagta ytcaaataat g                                               21


<210>  1895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1895
agactaagtt matgatacat a                                               21


<210>  1896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1896
ttggaactga staaagaaac a                                               21


<210>  1897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1897
tttctgcact kaaattagga t                                               21


<210>  1898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1898
tttaagctat rcagatgtct g                                               21


<210>  1899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1899
gtaaatgtct stactatgcc a                                               21


<210>  1900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1900
ctgctgtcaa kaaatttcta t                                               21


<210>  1901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1901
ccaagagagt rctaactcag t                                               21


<210>  1902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1902
tttaaaatgt rtctctctgt g                                               21


<210>  1903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1903
ctgcatgaca ygatcttttt t                                               21


<210>  1904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1904
tacagatgtt rtttaagaat a                                               21


<210>  1905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1905
cccactgatg rttacttcat a                                               21


<210>  1906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1906
tcagtgtaat ragcagctca g                                               21


<210>  1907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1907
tcacctcaca rgtttaagtt t                                               21


<210>  1908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1908
agagtagtat katgtgacag t                                               21


<210>  1909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1909
gccaatcccg rccctatcat g                                               21


<210>  1910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1910
caaaagcaat ygaagtccta g                                               21


<210>  1911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1911
caaaaagttt rtaaggattt g                                               21


<210>  1912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1912
gttatcagaa yatatgtcca a                                               21


<210>  1913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1913
gctaacactt ygtaaggtgg a                                               21


<210>  1914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1914
cggatcactg rgctcaatgt c                                               21


<210>  1915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1915
cacccagaat ytccccagtg g                                               21


<210>  1916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1916
tggtaagcaa mggagaggag a                                               21


<210>  1917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1917
caataggtac rctcctctgt a                                               21


<210>  1918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1918
tacaacacaa sacttgtaac a                                               21


<210>  1919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1919
gtgaattatg ytgtgatgaa c                                               21


<210>  1920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1920
aaatctgtct mcaactaaaa t                                               21


<210>  1921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1921
taaccacatc rcaccagcgt t                                               21


<210>  1922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1922
agaggttatt rggtttggag g                                               21


<210>  1923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1923
acccatggta ygctgagtcc t                                               21


<210>  1924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1924
caatccaaga yggcaggcag t                                               21


<210>  1925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1925
catgggaggg ytctacatgt t                                               21


<210>  1926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1926
tagggggcat ktcatggctg c                                               21


<210>  1927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1927
gtgccttagg yataatgtca a                                               21


<210>  1928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1928
taggaaaatt kcttcgtttc t                                               21


<210>  1929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1929
aacagaagcc rcagtgatct t                                               21


<210>  1930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1930
attgaacaaa yatttataga c                                               21


<210>  1931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1931
gtgccagtgc ratggacagg g                                               21


<210>  1932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1932
agttcaaccc wcaacaccgg t                                               21


<210>  1933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1933
tctgtatttg ycaactaaat a                                               21


<210>  1934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1934
taagtcagac rttaaagaca t                                               21


<210>  1935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1935
cctgctcagc wtggctgatg g                                               21


<210>  1936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1936
gcctagacta rgctccacag g                                               21


<210>  1937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1937
tccacgtgat ytgtacattt c                                               21


<210>  1938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1938
gaaacataac yatatgatac a                                               21


<210>  1939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1939
ctgggctttt yggaaggcag a                                               21


<210>  1940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1940
agagacacac rtaaaatcca g                                               21


<210>  1941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1941
atcctgtttc rtggctctat g                                               21


<210>  1942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1942
acttcatgca ktcaactatt a                                               21


<210>  1943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1943
tcatctgcaa wtgatttcat a                                               21


<210>  1944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1944
tatggattaa ytggaggtaa a                                               21


<210>  1945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1945
taatgagcca ytgctattga a                                               21


<210>  1946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1946
ctaggccccc yggctgactg t                                               21


<210>  1947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1947
tgtgctaaaa stgagagaag t                                               21


<210>  1948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1948
aattttccct yctcccatat c                                               21


<210>  1949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1949
cagaacctga ygctttggaa g                                               21


<210>  1950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1950
aaaaaaggaa saaaggaaga g                                               21


<210>  1951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1951
tgaaagacta kgatggacca a                                               21


<210>  1952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1952
tgcccagccc wtctcctctt t                                               21


<210>  1953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1953
cattccattc stagggattc a                                               21


<210>  1954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1954
tttgagggca yttgagttta t                                               21


<210>  1955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1955
taatatctcc ratacatgct g                                               21


<210>  1956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1956
tcctaaaaaa wgtcttctag a                                               21


<210>  1957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1957
agtgaacaca wcctcaacat t                                               21


<210>  1958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1958
aattcattca rtaaacatcg a                                               21


<210>  1959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1959
cttgaatgcc rccatactca t                                               21


<210>  1960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1960
acgatattaa ygtttccctg a                                               21


<210>  1961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1961
aaaaaagact raaaaatttg g                                               21


<210>  1962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1962
tcttttaccc mgaaggtggt a                                               21


<210>  1963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1963
tggatggata kttgaaggct a                                               21


<210>  1964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1964
taaatcataa wcaatgcttc a                                               21


<210>  1965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1965
atgaaaagtg ktatgtttta a                                               21


<210>  1966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1966
tggaagattt ygaaatatcc a                                               21


<210>  1967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1967
attcaagtta yaaaaatgtg c                                               21


<210>  1968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1968
ttggataaat rtcgacaacc a                                               21


<210>  1969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1969
actaggtagg yttgtgtcta g                                               21


<210>  1970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1970
cttaacaatg sagaattact a                                               21


<210>  1971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1971
agtagtatta rgttgtaatc a                                               21


<210>  1972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1972
atgagtttag ygtgtgtaaa c                                               21


<210>  1973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1973
ctgacatgaa ygctccatct c                                               21


<210>  1974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1974
aggattaatt macactactg a                                               21


<210>  1975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1975
cataacaaaa scagatttag t                                               21


<210>  1976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1976
ggcttgaaca rtgactctag g                                               21


<210>  1977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1977
gctcttattt rtaggaaata g                                               21


<210>  1978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1978
tttagtatga rctttgcata t                                               21


<210>  1979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1979
tcgttggaga yagagctttg g                                               21


<210>  1980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1980
aagaaaacta racagaagtc t                                               21


<210>  1981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1981
attctgctta rctatttctc t                                               21


<210>  1982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1982
tggaggattt ycagacattt g                                               21


<210>  1983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1983
tgctccatgc mataataatg t                                               21


<210>  1984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1984
atgatgctca ragagtaaag g                                               21


<210>  1985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1985
aaagctaagt scaaaagtga t                                               21


<210>  1986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1986
ctgcagtcaa sttgggaacg a                                               21


<210>  1987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1987
aaatgtttac ygtggtgcaa t                                               21


<210>  1988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1988
aatagcatta sattgagaat a                                               21


<210>  1989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1989
agagaaagat wtcatccaga g                                               21


<210>  1990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1990
cattgttgca yaggtgaatg a                                               21


<210>  1991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1991
ctgttgttaa ygtggtacct t                                               21


<210>  1992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1992
ccataggaga sagaacctca c                                               21


<210>  1993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1993
agacatatag ygatactcta c                                               21


<210>  1994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1994
ttgttcccca kcttctcctt c                                               21


<210>  1995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1995
ttaccgccac rtcttggtaa t                                               21


<210>  1996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1996
aacccaccaa ktaggtacag a                                               21


<210>  1997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1997
attttcccat mtatttctgc a                                               21


<210>  1998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1998
cttcagggct mtcaaggtat g                                               21


<210>  1999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1999
tattaagtca kcagatattg c                                               21


<210>  2000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2000
gccaccaggt rgagaaggaa a                                               21


<210>  2001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2001
tgttgatact rttgtattgt a                                               21


<210>  2002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2002
agaggatttc kggtaccaca g                                               21


<210>  2003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2003
tctctcacac kttaggaagc c                                               21


<210>  2004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2004
ttggggaaaa ygccaccatg c                                               21


<210>  2005
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2005
gtcggaccca rgaccctggg a                                               21


<210>  2006
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2006
tctaacttcc yaactgcggc c                                               21


<210>  2007
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2007
gctgcacaac rctgagaata t                                               21


<210>  2008
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2008
aactgaaaac rtgcatgtcc a                                               21


<210>  2009
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2009
cttggattta ygggagccct t                                               21


<210>  2010
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2010
accacccgtg kgactctgag c                                               21


<210>  2011
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2011
ctcaggtggg yagctcagaa a                                               21


<210>  2012
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2012
catgctcaga ygtgtggccc c                                               21


<210>  2013
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2013
accatctatt ygtgtaatac t                                               21


<210>  2014
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2014
atttcgtgtc kctcaaagta t                                               21


<210>  2015
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2015
agcctcaact ratatccaca t                                               21


<210>  2016
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2016
ataggcattc ycatatacag t                                               21


<210>  2017
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2017
attaagtgca rctattatca a                                               21


<210>  2018
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2018
catcaaataa rtaacctgca g                                               21


<210>  2019
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2019
ggctaagtac yatgttgtcc t                                               21


<210>  2020
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2020
gccagagccc ktttcttggt c                                               21


<210>  2021
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2021
gcttggaatt mtctctctat c                                               21


<210>  2022
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2022
agagagataa sacaagatga c                                               21


<210>  2023
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2023
gaggccctta scaccttccc a                                               21


<210>  2024
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2024
tgtttacttc yaagctcctt t                                               21


<210>  2025
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2025
tctgtcgggc ragcatttgg a                                               21


<210>  2026
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2026
taggtttagt ractttagag t                                               21


<210>  2027
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2027
aacatgctgc ygtcctagaa g                                               21


<210>  2028
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2028
gcaggcacca rattctattc a                                               21


<210>  2029
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2029
tctagatcac ygtatgaggc g                                               21


<210>  2030
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2030
gaaaggcgtt satttttgag g                                               21


<210>  2031
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2031
attagatcac ygatgctcac t                                               21


<210>  2032
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2032
gctgaccacc rgcgggatgg c                                               21


<210>  2033
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2033
atgctgctta ycttatagga c                                               21


<210>  2034
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2034
gttttacaaa yagtgctaaa a                                               21


<210>  2035
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2035
ggaaaaccaa rtaactagca c                                               21


<210>  2036
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2036
ttctccacag ktgtattcag t                                               21


<210>  2037
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2037
tatgttgcta ygtgggaggt g                                               21


<210>  2038
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2038
ataattttag raaatttaaa a                                               21


<210>  2039
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2039
caattaaggg ygctttacaa a                                               21


<210>  2040
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2040
tatggctttg sggacagata a                                               21


<210>  2041
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2041
gagaatgcat ygtatcccag a                                               21


<210>  2042
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2042
ggctttggac yatactttgg g                                               21


<210>  2043
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2043
atggaatagc rtaggagagc c                                               21


<210>  2044
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2044
aacctagatg rccaggaaga g                                               21


<210>  2045
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2045
gataggcggt scctctacag c                                               21


<210>  2046
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2046
agatttttac rtggcattcg c                                               21


<210>  2047
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2047
tcttaatgca rtataaccag t                                               21


<210>  2048
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2048
tcagagagac raggacttat c                                               21


<210>  2049
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2049
aagctaaaaa magattgcaa a                                               21


<210>  2050
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2050
gaaaatacta ygggctgtct c                                               21


<210>  2051
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2051
aaatggaagt rcagtggcct c                                               21


<210>  2052
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2052
atgggtggaa yaggcagagt a                                               21


<210>  2053
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2053
ttttggtcca yaaagctagt g                                               21


<210>  2054
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2054
ttttatttgg ragttagcat a                                               21


<210>  2055
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2055
gacagagatc yatttaaggc a                                               21


<210>  2056
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2056
caccatagga ygtcaggttt t                                               21


<210>  2057
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2057
atttcaactt yttgaactgg c                                               21


<210>  2058
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2058
aaacctactt wtgtcccagg t                                               21


<210>  2059
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2059
tgttctttgt ygtaaattca g                                               21


<210>  2060
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2060
atacattatt wagagcacag t                                               21


<210>  2061
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2061
cttttctata saagtctagt a                                               21


<210>  2062
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2062
atatccaaat kgaacatcca g                                               21


<210>  2063
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2063
aagcacttca yaaggtataa t                                               21


<210>  2064
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2064
tgtgaccatg ragaaatgta t                                               21


<210>  2065
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2065
acaatatgta ygtgatcaac t                                               21


<210>  2066
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2066
atgtttttat rggattaaag t                                               21


<210>  2067
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2067
gtgataaggc yattatagca t                                               21


<210>  2068
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2068
actcccctca ygtctgttgg c                                               21


<210>  2069
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2069
gcaccatcac sgggccctgg g                                               21


<210>  2070
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2070
tactgcagat rtaaaaaatg c                                               21


<210>  2071
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2071
accacttaga wggatgtctg a                                               21


<210>  2072
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2072
aagggaatcc raggagatct a                                               21


<210>  2073
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2073
gtttaataaa ygccaccaac g                                               21


<210>  2074
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2074
tttaggcact rtaggtactg t                                               21


<210>  2075
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2075
tggtatgtgg yaagcattca a                                               21


<210>  2076
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2076
gataagctga yaatgtgcaa a                                               21


<210>  2077
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2077
acaaataaga kaattcagag a                                               21


<210>  2078
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2078
cctgctgcca ygttgtatgc c                                               21


<210>  2079
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2079
gggctaaatt yagtgtttca a                                               21


<210>  2080
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2080
actcctaacc yttagcaggc t                                               21


<210>  2081
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2081
tcaggttttc yatgttctgc t                                               21


<210>  2082
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2082
gaaaatgcct kccacactta g                                               21


<210>  2083
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2083
tttgtgttta yttttcaaga t                                               21


<210>  2084
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2084
ttaagaggat ytatgaggca c                                               21


<210>  2085
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2085
acactcctat scactgtgta a                                               21


<210>  2086
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2086
gtctgtgtct yaaatttaca t                                               21


<210>  2087
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2087
ccgtagcaac rtagtattct g                                               21


<210>  2088
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2088
gcaaacttaa ygcagaatct a                                               21


<210>  2089
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2089
ctaatctcaa kaattaaatg a                                               21


<210>  2090
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2090
aaattaaagt rtatactcct g                                               21


<210>  2091
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2091
attcttatta ygtaacttcg a                                               21


<210>  2092
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2092
gattgtttta wcaggaagtt a                                               21


<210>  2093
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2093
ctttcaaatt ytagctcaag a                                               21


<210>  2094
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2094
tattttcttg ygctcccagg a                                               21


<210>  2095
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2095
tctttttcct rgctttccct g                                               21


<210>  2096
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2096
ctctcattgc magccaaatt c                                               21


<210>  2097
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2097
gatactcctg rgaatgctga a                                               21


<210>  2098
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2098
gtttgagttt rggccagttt a                                               21


<210>  2099
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2099
ctcactccca rttgatgatg g                                               21


<210>  2100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2100
acgtccagac rgggttacga c                                               21


<210>  2101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2101
tccaaaacta rcaagatggg g                                               21


<210>  2102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2102
gcaatagtgt racgtctggt t                                               21


<210>  2103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2103
gcatctattt rcccctgtat c                                               21


<210>  2104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2104
tctcagtagt rtaggttcct a                                               21


<210>  2105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2105
tttcatggca rcttccttca a                                               21


<210>  2106
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2106
attcagaaaa mataatccat g                                               21


<210>  2107
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2107
tcctcagcct rtaagacaca t                                               21


<210>  2108
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2108
ttcttggtcc yttaatttaa t                                               21


<210>  2109
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2109
caggtcttag rgaatgggcg a                                               21


<210>  2110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2110
cttggagact rggatctttt t                                               21


<210>  2111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2111
gcaacctgac rcgctatggg a                                               21


<210>  2112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2112
cttggcggca rgaaggtggg g                                               21


<210>  2113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2113
ccccttcatc rgtcacgtta a                                               21


<210>  2114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2114
gactgcatgc yaggaaggac t                                               21


<210>  2115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2115
acaaaagtcc yaggacaggt c                                               21


<210>  2116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2116
agtgaatagg wcaaggcaga t                                               21


<210>  2117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2117
tgttgaactt stgctgaaca a                                               21


<210>  2118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2118
aggtcctggg magccacctg t                                               21


<210>  2119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2119
ctgagacgca sgagttttga a                                               21


<210>  2120
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2120
gcagagccca rccctgggct g                                               21


<210>  2121
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2121
tgccacccaa kgacccacat g                                               21


<210>  2122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2122
ctccaaatac katactaatt g                                               21


<210>  2123
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2123
ggctacacca mctacataag c                                               21


<210>  2124
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2124
caaacatgaa yaatgaaaca c                                               21


<210>  2125
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2125
gaagcacacc rgcaggctgg a                                               21


<210>  2126
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2126
tcaccaaatc mtgcaaaaat c                                               21


<210>  2127
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2127
aagttcatca mcctgagcta a                                               21


<210>  2128
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2128
ttggctgttc rtatacctgg a                                               21


<210>  2129
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2129
gatggctgaa kttaccaact c                                               21


<210>  2130
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2130
acaccataaa ygacaacatt t                                               21


<210>  2131
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2131
caggaaaaac rtagcctccc t                                               21


<210>  2132
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2132
agggactaac rtagaagtga a                                               21


<210>  2133
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2133
ttgctctcca ragagtttaa g                                               21


<210>  2134
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2134
aggacaaaca scatttttct c                                               21


<210>  2135
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2135
ctgggaaaat ygaaattaca a                                               21


<210>  2136
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2136
cacttcttac wtactttccg t                                               21


<210>  2137
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2137
ccagctccca rctccaccta c                                               21


<210>  2138
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2138
ccaaatataa raagtgcaac t                                               21


<210>  2139
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2139
ctgtgaggat rgagacaagg g                                               21


<210>  2140
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2140
tccagctgca sagttggctg c                                               21


<210>  2141
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2141
ttagtctgct wtcacatgta a                                               21


<210>  2142
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2142
gaaacttacc rtaaccaagt t                                               21


<210>  2143
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2143
cattgtttct rcttcactcc t                                               21


<210>  2144
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2144
ctctgggtat rgcctgcaaa a                                               21


<210>  2145
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2145
gtagattatc rtgttacagt g                                               21


<210>  2146
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2146
aatcaataat ytcagtaagc a                                               21


<210>  2147
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2147
gacctggttc yaaacagact a                                               21


<210>  2148
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2148
agccatttgc ytttagactt a                                               21


<210>  2149
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2149
ccatttgtag rtgtgcatat t                                               21


<210>  2150
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2150
tttacccact rgactttgta a                                               21


<210>  2151
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2151
aaagcagtca saacattcat a                                               21


<210>  2152
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2152
ttaaccagaa ratgtgaacc a                                               21


<210>  2153
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2153
aacctcagct yttatgtcac t                                               21


<210>  2154
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2154
catacaccat wtatctctca c                                               21


<210>  2155
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2155
ttcatcacaa yttgggaacg t                                               21


<210>  2156
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2156
tgctataatg ytgtttatta a                                               21


<210>  2157
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2157
attttctatg yttttctgtg a                                               21


<210>  2158
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2158
atctggtagc ragtatctgg t                                               21


<210>  2159
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2159
ttcaccagta raatgtaaga t                                               21


<210>  2160
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2160
gaaaagcaac stccaaataa g                                               21


<210>  2161
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2161
gcattttaat yctaaattat c                                               21


<210>  2162
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2162
taagcatagc rccaaatagt t                                               21


<210>  2163
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2163
agtggcaaga scactcttcc g                                               21


<210>  2164
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2164
tctttaacac saggcttctc a                                               21


<210>  2165
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2165
aagacttagg magcctctgc t                                               21


<210>  2166
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2166
cagtgccttc yactctgtct g                                               21


<210>  2167
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2167
gatctatttg wtaacagcaa t                                               21


<210>  2168
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2168
tagaaatttt raaaagtcat a                                               21


<210>  2169
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2169
tcctcattcc wcttcaacca g                                               21


<210>  2170
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2170
taccataagg sctgcattcc t                                               21


<210>  2171
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2171
tgaacacggt rgcaacatgc a                                               21


<210>  2172
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2172
aattctgaaa yacatgtgag g                                               21


<210>  2173
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2173
aacatggggc wttattatag a                                               21


<210>  2174
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2174
tccagattcc ygggcctcag g                                               21


<210>  2175
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2175
ggtttcaaat yctaacactc t                                               21


<210>  2176
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2176
tgaataccgc ygaaatggtg c                                               21


<210>  2177
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2177
cttttagatg ytactatacc t                                               21


<210>  2178
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2178
gcagaactca rtcattgctg a                                               21


<210>  2179
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2179
agttaattca rgtcctccag t                                               21


<210>  2180
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2180
caccaaagat kttaacattg a                                               21


<210>  2181
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2181
agccacttta raatggttga t                                               21


<210>  2182
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2182
atcatatagc rtgtgttttg t                                               21


<210>  2183
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2183
gattatgttc ygtagacttt a                                               21


<210>  2184
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2184
taccaagaat rtatgtaata c                                               21


<210>  2185
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2185
tactataaat ktacaaaaac c                                               21


<210>  2186
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2186
tgccatttat ygacaaaatg a                                               21


<210>  2187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2187
gagaggaagt raaaattgca t                                               21


<210>  2188
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2188
tactttttct yaaagttgtt c                                               21


<210>  2189
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2189
aaggtgagtc ygacctaaat g                                               21


<210>  2190
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2190
cacaaaattg rgtagatata c                                               21


<210>  2191
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2191
acctttgaca ygaaacttga c                                               21


<210>  2192
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2192
ctatccacaa rggctttttt t                                               21


<210>  2193
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2193
gtccaggtgg yatggcttcc a                                               21


<210>  2194
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2194
acagtcctct sctctcaaat t                                               21


<210>  2195
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2195
gcagtaggaa yagaatttgg t                                               21


<210>  2196
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2196
tactgtctgt yctctaccaa a                                               21


<210>  2197
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2197
gggactccac macaagaaac c                                               21


<210>  2198
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2198
ccagtgcagt kcttctcaaa a                                               21


<210>  2199
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2199
ggtttgcaga ygaaggggaa a                                               21


<210>  2200
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2200
atgacactcc sgaaaatttc a                                               21


<210>  2201
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2201
ggtcacggct scttgactca c                                               21


<210>  2202
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2202
gaactctagc rtgtttagat c                                               21


<210>  2203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2203
ttattgtcag wtaaacttct t                                               21


<210>  2204
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2204
aatacgggac ytgatttgag t                                               21


<210>  2205
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2205
gggaagagcc rtaacttcaa g                                               21


<210>  2206
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2206
tccatcagag yggctaatgg t                                               21


<210>  2207
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2207
ttcatatctc ygctttctca t                                               21


<210>  2208
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2208
atgaaggtga rtaaaacatg g                                               21


<210>  2209
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2209
cccctggcac rtacctcatt t                                               21


<210>  2210
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2210
atgattcttt yagctctgag a                                               21


<210>  2211
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2211
aagcttactc kgcttcttga t                                               21


<210>  2212
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2212
tagaaccatt ragctagaat c                                               21


<210>  2213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2213
ctactttagg wagagttgtc a                                               21


<210>  2214
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2214
ctgtcagaag rtatatttcc t                                               21


<210>  2215
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2215
aagttcgtac sgtttccagc a                                               21


<210>  2216
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2216
cctcctgtga mttttccccc c                                               21


<210>  2217
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2217
aataaatata ytccatatgc t                                               21


<210>  2218
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2218
cagaaaaaaa wgtaggctac a                                               21


<210>  2219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2219
atgagaagag ragataactg a                                               21


<210>  2220
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2220
aaaaacgtct ygtgtatcct c                                               21


<210>  2221
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2221
tagtagtgtg rgcaagtttc t                                               21


<210>  2222
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2222
atacagttta rtttaatatt t                                               21


<210>  2223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2223
actgtagcct rtcttaccag t                                               21


<210>  2224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2224
aacggcaaca ytaccttgag a                                               21


<210>  2225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2225
ttggggaatc rtgctagaag a                                               21


<210>  2226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2226
aaaagaagga ygagattaca a                                               21


<210>  2227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2227
atcacaataa sactatatca a                                               21


<210>  2228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2228
cctaaagtat rtaacaaagg t                                               21


<210>  2229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2229
cccaaccaaa magaaaaata a                                               21


<210>  2230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2230
gacttgagaa mctgttgttg c                                               21


<210>  2231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2231
aggcctatgg rtattcctgt t                                               21


<210>  2232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2232
ggaaagttcc magaagagtg a                                               21


<210>  2233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2233
catccctgaa katacctttt g                                               21


<210>  2234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2234
tccaggagaa rgtctcaatt a                                               21


<210>  2235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2235
agcaccatta maaaaatctt g                                               21


<210>  2236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2236
ggaatagtgt yggaaatttg t                                               21


<210>  2237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2237
tcatcctctt kattgtcctc a                                               21


<210>  2238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2238
gtagtgatga ktgggacata t                                               21


<210>  2239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2239
aagctaaaaa rtgtctaagt t                                               21


<210>  2240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2240
gatgagcact kagcaaacat c                                               21


<210>  2241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2241
tggtttcaat wctggaatct t                                               21


<210>  2242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2242
catcactaga scatattttt c                                               21


<210>  2243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2243
cttaccatat rtgatgttct c                                               21


<210>  2244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2244
acaggacctt yaagtcacat g                                               21


<210>  2245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2245
gtctgaagtc wtcaaaaatg a                                               21


<210>  2246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2246
tggaagggcc satatttaac a                                               21


<210>  2247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2247
aacatttaac wtgaacttga a                                               21


<210>  2248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2248
aaaaattctc stcttacagg g                                               21


<210>  2249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2249
cagatctttt saggcagaac t                                               21


<210>  2250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2250
acggggtctg ygtgaccttc t                                               21


<210>  2251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2251
aaaaaagaaa yagcaattat g                                               21


<210>  2252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2252
tactcatgag scatatgctg t                                               21


<210>  2253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2253
ggcaaagcac mccaaaaatc t                                               21


<210>  2254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2254
ttacctgtca ytcttttccc t                                               21


<210>  2255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2255
aaaggaacca ygggtaccaa c                                               21


<210>  2256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2256
aatgggatga ygcctattta t                                               21


<210>  2257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2257
tgccatctca ygttgttggt g                                               21


<210>  2258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2258
gggtctacag wggctggttc g                                               21


<210>  2259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2259
tttttacttg wctgcacaat c                                               21


<210>  2260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2260
tgtaacaggg sggtctggta c                                               21


<210>  2261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2261
tagaatggag rtggctacca a                                               21


<210>  2262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2262
atatatgaca kggtaagttt c                                               21


<210>  2263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2263
agcattctct ktattgagac a                                               21


<210>  2264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2264
ctgtttgatc rcttgcagaa a                                               21


<210>  2265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2265
acacttccta ygccctatat a                                               21


<210>  2266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2266
gaataatgca rtgatttgaa a                                               21


<210>  2267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2267
tgttgtttta stggtatgag a                                               21


<210>  2268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2268
tgaggcaaac ktgatccaga a                                               21


<210>  2269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2269
atgtactcat yagggaaaaa a                                               21


<210>  2270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2270
agattgatga ygggcaacgg t                                               21


<210>  2271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2271
gaaaccctgg rcaaaactgt t                                               21


<210>  2272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2272
ttgtgtgatc yaaatgattg a                                               21


<210>  2273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2273
ttttattaca yagttacgta c                                               21


<210>  2274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2274
gagggaaaga ytctgatttt t                                               21


<210>  2275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2275
ttctttattc rttgttgtta c                                               21


<210>  2276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2276
caaaagagga wcatagaatt g                                               21


<210>  2277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2277
cttcattcac ytttgttttc a                                               21


<210>  2278
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2278
ctgaagttat rtaatgggca c                                               21


<210>  2279
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2279
aagggtgaca ragttttgga a                                               21


<210>  2280
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2280
agagacgctt ycaggagaat g                                               21


<210>  2281
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2281
tcctgaataa ratcattact a                                               21


<210>  2282
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2282
cagtaagctc yttccaaatg a                                               21


<210>  2283
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2283
tatggactac ragggcttct a                                               21


<210>  2284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2284
aatgtcagca rtgaccttga a                                               21


<210>  2285
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2285
acatggcatc rgaatattaa t                                               21


<210>  2286
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2286
gttcaatgca ycatcctccc c                                               21


<210>  2287
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2287
actctacaaa mcttatgagt g                                               21


<210>  2288
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2288
aactaaacag ygagcaaaac a                                               21


<210>  2289
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2289
cattgtcagc rtgttgagga c                                               21


<210>  2290
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2290
attggaaccc rgacagggca t                                               21


<210>  2291
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2291
tggtattact yccatctctc c                                               21


<210>  2292
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2292
tagtttagaa rgcaagatca c                                               21


<210>  2293
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2293
caagaatacc yggctccttt t                                               21


<210>  2294
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2294
acagagtacc rtgtcaggta a                                               21


<210>  2295
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2295
gaagaggcca yagaattgaa a                                               21


<210>  2296
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2296
tgtatgtctc watatgaata t                                               21


<210>  2297
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2297
aagagaacag mtggtaacaa g                                               21


<210>  2298
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2298
agatggttta yggagtgacc c                                               21


<210>  2299
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2299
cctcaataaa yggcatggtc c                                               21


<210>  2300
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2300
tgtgcaaaat rgcctgccaa a                                               21


<210>  2301
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2301
ccagtagagc ytttctaaac t                                               21


<210>  2302
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2302
caggaatttc wtttgacatg t                                               21


<210>  2303
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2303
tagctgttct stcttttgat a                                               21


<210>  2304
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2304
gtagtttgta sctaatgttt t                                               21


<210>  2305
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2305
gtgaactgaa mtgggtccat c                                               21


<210>  2306
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2306
ttttccccca ractgtactc c                                               21


<210>  2307
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2307
caaacatttc ytgaaattgg a                                               21


<210>  2308
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2308
atatacataa rgcaatacac c                                               21


<210>  2309
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2309
atttatttcc yctctgtcta g                                               21


<210>  2310
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2310
aaggtgtatt ytatgtcact t                                               21


<210>  2311
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2311
aatagctgcc wgatgaaaca g                                               21


<210>  2312
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2312
atgtgaaaga ygagactcac a                                               21


<210>  2313
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2313
aagacttaca ytttttgcta c                                               21


<210>  2314
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2314
agaatagatt rttgaagagt t                                               21


<210>  2315
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2315
atatcgtctc ygttttgagg g                                               21


<210>  2316
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2316
agaattggga sgtagtacag c                                               21


<210>  2317
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2317
gcttctcaag kcactagctt g                                               21


<210>  2318
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2318
tagtagaaac ygtaactgtc c                                               21


<210>  2319
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2319
ttggagtagc rtccagaatt a                                               21


<210>  2320
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2320
aaatgaaagt ktatgtactg a                                               21


<210>  2321
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2321
ttaaggtttc mgtatatgaa t                                               21


<210>  2322
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2322
gcaaaagcaa yagttgtagt g                                               21


<210>  2323
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2323
cttaataggg ragctttatc a                                               21


<210>  2324
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2324
ggggggctca ytatggtctc t                                               21


<210>  2325
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2325
gaaattattt rctgatcggg c                                               21


<210>  2326
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2326
ccttttctca ygcattcatt c                                               21


<210>  2327
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2327
atagatattt ktcatctgag g                                               21


<210>  2328
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2328
tctgacctag yatgtcttct c                                               21


<210>  2329
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2329
ccacgtagag raaatttaag t                                               21


<210>  2330
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2330
tactcatcac waatgcacaa a                                               21


<210>  2331
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2331
ggggtggtgc yctgaactga a                                               21


<210>  2332
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2332
ctgccaaaaa ygcttgggag g                                               21


<210>  2333
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2333
gattggcaac rtctgcatta a                                               21


<210>  2334
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2334
gaattcaaag wtaatgccta c                                               21


<210>  2335
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2335
tttgatctct rtttcttaat a                                               21


<210>  2336
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2336
atggctattc rtagagatca t                                               21


<210>  2337
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2337
acaattcaga ytttggacat g                                               21


<210>  2338
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2338
tgattagaag saaaggaaga t                                               21


<210>  2339
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2339
gatattaacc ytttgtttgc a                                               21


<210>  2340
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2340
tgctaaactg matgtaaact c                                               21


<210>  2341
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2341
gctaacagtc yaatttgaag a                                               21


<210>  2342
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2342
tattttgcac scagttgtga t                                               21


<210>  2343
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2343
tttcatttcc rcttcttttg c                                               21


<210>  2344
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2344
ctttaaatac stcaaaataa a                                               21


<210>  2345
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2345
tcctgcacga ytgatgaaac a                                               21


<210>  2346
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2346
actgagttca sgggacaaga a                                               21


<210>  2347
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2347
atgaccggcc mcactgtgac a                                               21


<210>  2348
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2348
gtgctatggg yacgtattag a                                               21


<210>  2349
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2349
ctgacaatta stgtactgtg a                                               21


<210>  2350
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2350
agtaatgatg rcagtgatat t                                               21


<210>  2351
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2351
gctggatgac rataagcctg g                                               21


<210>  2352
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2352
ataaaacttt rgctgcttaa c                                               21


<210>  2353
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2353
caggggccag rgcacagttg t                                               21


<210>  2354
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2354
catgatggat raataagaaa c                                               21


<210>  2355
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2355
aagtaagctc rtgaagctat t                                               21


<210>  2356
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2356
gcattatact rtctctgtaa g                                               21


<210>  2357
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2357
tcatttgtaa rgctcctgtg a                                               21


<210>  2358
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2358
cttcctttac rctgaacggg t                                               21


<210>  2359
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2359
catcttgtat kttcttgggc t                                               21


<210>  2360
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2360
acaattgacc rtatttgaaa t                                               21


<210>  2361
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2361
tattattatc rtaactgcaa t                                               21


<210>  2362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2362
ttggaacaca kcaggtgatt a                                               21


<210>  2363
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2363
cctcacagta ytctgaaatt t                                               21


<210>  2364
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2364
gcatctagga rggatttata t                                               21


<210>  2365
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2365
aaggagaaag saaagtatgg a                                               21


<210>  2366
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2366
acaatatcaa sacgcttaac a                                               21


<210>  2367
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2367
gaaggtgggc rctaggtaaa c                                               21


<210>  2368
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2368
ctagtttacc rctcagatct c                                               21


<210>  2369
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2369
aaattatgaa wggatgaatt a                                               21


<210>  2370
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2370
attgagaaac ycttcacagc a                                               21


<210>  2371
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2371
aaatattctc yagtcacttt c                                               21


<210>  2372
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2372
gagagagcag ytgggaaaga a                                               21


<210>  2373
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2373
tacagtacct sagtttctca t                                               21


<210>  2374
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2374
tagcaattag kcttgaaccc a                                               21


<210>  2375
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2375
gaagaagcag stctagcaca g                                               21


<210>  2376
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2376
ttcattctct ytgccctgca t                                               21


<210>  2377
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2377
acaatatgct raagtatgaa t                                               21


<210>  2378
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2378
gtttccaaaa rttgtattat a                                               21


<210>  2379
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2379
caatgaatac ytagaaaatt c                                               21


<210>  2380
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2380
gttagcctgg kccctgtact t                                               21


<210>  2381
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2381
tcatggtgta ygtggaaaac t                                               21


<210>  2382
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2382
aaataacatg ygctaagggt t                                               21


<210>  2383
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2383
caggctacta rtattagaat t                                               21


<210>  2384
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2384
atattagtta yactgaacat a                                               21


<210>  2385
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2385
cataatcaca ytacattata t                                               21


<210>  2386
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2386
atattttgca rgacactgtt c                                               21


<210>  2387
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2387
tttatgggga wttttttatg c                                               21


<210>  2388
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2388
tacagagact wcaccatata a                                               21


<210>  2389
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2389
atttcatcct saaaaacaca a                                               21


<210>  2390
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2390
ttgtttttat wctccttaca a                                               21


<210>  2391
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2391
catgcacgct stcagtggag t                                               21


<210>  2392
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2392
cagtggagat ycatgtccaa g                                               21


<210>  2393
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2393
ttagtgaaat ygttgtgtta a                                               21


<210>  2394
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2394
agtaaaattc yggataatct a                                               21


<210>  2395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2395
ttcatgcatt yaactactgt t                                               21


<210>  2396
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2396
gaagtatgtt mttttattca t                                               21


<210>  2397
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2397
attccagtca kgagcagaca c                                               21


<210>  2398
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2398
ttcactcttc yttccaatga a                                               21


<210>  2399
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2399
tgtaaaatat raagtccaag t                                               21


<210>  2400
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2400
ccatataaat katcttaagc a                                               21


<210>  2401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2401
ctcttaaact rtactttcca t                                               21


<210>  2402
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2402
tttttaatgc rtatacaaac a                                               21


<210>  2403
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2403
tacacatagt ragtaacaat a                                               21


<210>  2404
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2404
aaaggttaca ycgaaattct a                                               21


<210>  2405
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2405
gcaaatatga kgtatatcaa t                                               21


<210>  2406
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2406
tcaaaaggaa rtcttactct t                                               21


<210>  2407
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2407
agtgcagcta yggaaggcaa t                                               21


<210>  2408
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2408
agaaagtttg wttaacaatt t                                               21


<210>  2409
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2409
tcagtattat kctaagtttc a                                               21


<210>  2410
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2410
ataagccaaa yatgaataca a                                               21


<210>  2411
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2411
ttgaagttct rttgtttgga t                                               21


<210>  2412
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2412
atgacaaaca ytctttaggt g                                               21


<210>  2413
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2413
gaactagacg ycagtcattt c                                               21


<210>  2414
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2414
aaccactttc rtgaagcaaa a                                               21


<210>  2415
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2415
tgcttagtag kgctccttca t                                               21


<210>  2416
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2416
caattttcct raaaaataac t                                               21


<210>  2417
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2417
ggaggctcat kgtgtctgca t                                               21


<210>  2418
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2418
aagaaacatg saattcaaga g                                               21


<210>  2419
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2419
ctctctgttg ygcttggaaa c                                               21


<210>  2420
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2420
agtaaatgca yaccattttc t                                               21


<210>  2421
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2421
ccattctatc rggaaaatct c                                               21


<210>  2422
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2422
aaataatcca stcaaataag g                                               21


<210>  2423
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2423
ttcatcgtag wtcaccgctt a                                               21


<210>  2424
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2424
gggaaggtct sacttcctga a                                               21


<210>  2425
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2425
tggggaggag rgagaggcct g                                               21


<210>  2426
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2426
ctgataaaaa ygtgattatt t                                               21


<210>  2427
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2427
atgtatttac ragagcattc a                                               21


<210>  2428
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2428
gtttttattt yaggtgtata c                                               21


<210>  2429
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2429
tagaccaggg katccagatg a                                               21


<210>  2430
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2430
catccatgga yacgtaggtt g                                               21


<210>  2431
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2431
tttcattaaa rtcaacattg a                                               21


<210>  2432
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2432
aattatcttg ytgatgacaa a                                               21


<210>  2433
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2433
aactcaaggt rgattaaaag t                                               21


<210>  2434
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2434
gtatcaaata yctttccagc a                                               21


<210>  2435
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2435
aaaccttttg yattttctaa a                                               21


<210>  2436
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2436
ttccaaagaa stccagtcag t                                               21


<210>  2437
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2437
tttgatcaaa yagcatagaa a                                               21


<210>  2438
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2438
tttttggccc rtgtgggaag g                                               21


<210>  2439
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2439
catgctagcc rctggatata c                                               21


<210>  2440
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2440
atgtttccac rtgtatccta c                                               21


<210>  2441
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2441
gaatcagatg yttgccagac a                                               21


<210>  2442
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2442
ttatgtgctg yagaaaaagt a                                               21


<210>  2443
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2443
gatttcctca ytgtctattg g                                               21


<210>  2444
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2444
agttcaccta yactttgaca a                                               21


<210>  2445
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2445
caagtaagcg rccgcgagta a                                               21


<210>  2446
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2446
ttggtgagct mttaccagaa g                                               21


<210>  2447
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2447
tttatgaaaa ytttttgtag g                                               21


<210>  2448
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2448
ttgggttccc rggagcccac g                                               21


<210>  2449
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2449
ctctgctata ygtttaaata g                                               21


<210>  2450
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2450
tcatgcgtgt yctcttcttg a                                               21


<210>  2451
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2451
gttccagaac rgatttagaa t                                               21


<210>  2452
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2452
gtgaaagatg ygggacccta a                                               21


<210>  2453
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2453
gttaaatgta yggctggccc a                                               21


<210>  2454
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2454
attgtcagta rgggtcctcc a                                               21


<210>  2455
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2455
cagctttttg maaagggctt g                                               21


<210>  2456
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2456
gctggtgcca sggagagttc c                                               21


<210>  2457
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2457
tttcacatag wttcttaagg g                                               21


<210>  2458
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2458
tggtgtcttc yagattctca a                                               21


<210>  2459
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2459
ttgttgttgt kttctccaag g                                               21


<210>  2460
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2460
gagcagcccc rcatcccaca t                                               21


<210>  2461
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2461
tgatgagagc ratgccgtag c                                               21


<210>  2462
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2462
ccaggacttc ygatggttct g                                               21


<210>  2463
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2463
ggatgtgagg yggtcataat a                                               21


<210>  2464
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2464
agcccattgc yggtacccat g                                               21


<210>  2465
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2465
cacaggtgat mtgaacccag c                                               21


<210>  2466
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2466
aggaagccac rggcctggag g                                               21


<210>  2467
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2467
agccctgtgc ygagccttcc t                                               21


<210>  2468
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2468
gcccagatgc maacagcagc c                                               21


<210>  2469
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2469
gagcttttgc yggcagtcat t                                               21


<210>  2470
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2470
gatcctttcc ygccaccttc a                                               21


<210>  2471
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2471
ttctagtgtt kcagagagct c                                               21


<210>  2472
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2472
aaactgctat ytgagtttca c                                               21


<210>  2473
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2473
ctttgtattc ktctaaaact g                                               21


<210>  2474
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2474
cacagctaaa magaagatgc c                                               21


<210>  2475
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2475
ggtacctgat yatgttcccc t                                               21


<210>  2476
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2476
ctgcgatata yggtcaacgc t                                               21


<210>  2477
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2477
taggtgaata yggtgtttca t                                               21


<210>  2478
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2478
ctgcagtatg wagttcatta g                                               21


<210>  2479
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2479
ttctggggca ycagaaaaat c                                               21


<210>  2480
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2480
gcacagggaa ytggcttgga a                                               21


<210>  2481
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2481
tgtgagtata kggaacagca g                                               21


<210>  2482
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2482
tctgtgccct raagagtggc c                                               21


<210>  2483
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2483
ttgtgatgag kaaagagaga t                                               21


<210>  2484
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2484
attcccttgg ycccaaatgc c                                               21


<210>  2485
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2485
tcactaaaga stccaaaata a                                               21


<210>  2486
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2486
ttaaggtaac rtgaatgcaa t                                               21


<210>  2487
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2487
cgacaatgct rctttcaagt c                                               21


<210>  2488
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2488
tgtgaatttt ytctggctgc c                                               21


<210>  2489
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2489
atgtgggatt kgattacaaa g                                               21


<210>  2490
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2490
ttggacttga rgtgcctcct c                                               21


<210>  2491
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2491
tccagcattt sacagagcag a                                               21


<210>  2492
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2492
tttcctgtca wtgaatgcat a                                               21


<210>  2493
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2493
cagcagcagg yctagtttat g                                               21


<210>  2494
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2494
tcagttttca wgtccacaga a                                               21


<210>  2495
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2495
ttttctacct kccctgactt t                                               21


<210>  2496
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2496
aggttgagga mactggttgg a                                               21


<210>  2497
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2497
tcttatcacc ragcttaaga g                                               21


<210>  2498
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2498
aggcatttca maagcatggg t                                               21


<210>  2499
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2499
atgcacagag yggtatgcaa c                                               21


<210>  2500
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2500
tatagataga wttgttacaa a                                               21


<210>  2501
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2501
aatacattct rcagactaat g                                               21


<210>  2502
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2502
ggccttatca ytgggcagcc c                                               21


<210>  2503
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2503
ggatagtgat ytcattagca a                                               21


<210>  2504
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2504
ggctcctgca stgctcacag c                                               21


<210>  2505
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2505
agattgattc rgcaaagaag a                                               21


<210>  2506
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2506
atagttacca yagagaaccc a                                               21


<210>  2507
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2507
ataaatcagc yatattgaca g                                               21


<210>  2508
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2508
ccaaaaagct yaaaggcagt t                                               21


<210>  2509
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2509
gcaagtaaac ktatttccac t                                               21


<210>  2510
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2510
gaaattacag rcttgtggtg c                                               21


<210>  2511
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2511
tgtatgttac yccacatggc a                                               21


<210>  2512
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2512
taggaatagt rtatagttag a                                               21


<210>  2513
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2513
tctgatgctt saggatgatg g                                               21


<210>  2514
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2514
tttcagaagc raagaatatt t                                               21


<210>  2515
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2515
cattaatcac rggtaaatta g                                               21


<210>  2516
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2516
aaatttcaaa yccttcatat g                                               21


<210>  2517
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2517
tcctttggct raacagatta g                                               21


<210>  2518
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2518
gaaggggcac rtctgacaat g                                               21


<210>  2519
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2519
cattagcact ygctgaggta a                                               21


<210>  2520
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2520
acttaaaaga ytgggacctt a                                               21


<210>  2521
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2521
tctctgcgtc rtttagaatg t                                               21


<210>  2522
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2522
gcccaagaac yggccggcta g                                               21


<210>  2523
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2523
tctgcgtgcc ytcacccatg t                                               21


<210>  2524
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2524
agctgtgggt ycctaggcaa a                                               21


<210>  2525
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2525
atgcagacag wggaacaggt g                                               21


<210>  2526
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2526
gtcctatata yggcattccc t                                               21


<210>  2527
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2527
ggttggatct ytatgccact t                                               21


<210>  2528
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2528
ccaggaagaa rgcctaatca a                                               21


<210>  2529
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2529
ccagactgct wtgctacctc t                                               21


<210>  2530
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2530
ttttctgtac yactattaca a                                               21


<210>  2531
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2531
tatttcatgc yttgaattgt g                                               21


<210>  2532
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2532
tttgttctaa rtggcactaa a                                               21


<210>  2533
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2533
agagaaaaag mgcccagttg a                                               21


<210>  2534
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2534
aaagaattaa rgctgagatt c                                               21


<210>  2535
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2535
tcctacttca wtttcctgag t                                               21


<210>  2536
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2536
aagactaata wcctctgcac t                                               21


<210>  2537
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2537
gagactcaca raataatact c                                               21


<210>  2538
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2538
ttttcatact rtatgggaat a                                               21


<210>  2539
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2539
tgtgctcagc rgcattactc t                                               21


<210>  2540
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2540
gtcattggca mttttttaac c                                               21


<210>  2541
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2541
taacaaatac rgtggtcata t                                               21


<210>  2542
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2542
gttaaggata rattagtaaa a                                               21


<210>  2543
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2543
tcacttttgt yccctcaaaa c                                               21


<210>  2544
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2544
gacagggata yaaaatcaat t                                               21


<210>  2545
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2545
aaactttgaa wtcatttgtg t                                               21


<210>  2546
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2546
gaacatgcga raaaaacaat t                                               21


<210>  2547
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2547
acataaaatg scgttactat a                                               21


<210>  2548
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2548
ccaggaaact wttatttaaa g                                               21


<210>  2549
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2549
tcttcagccc ygacctctat c                                               21


<210>  2550
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2550
aattcatgag ygctggagaa g                                               21


<210>  2551
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2551
agtgtcccta sgtaaataga a                                               21


<210>  2552
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2552
ctcagtgtga magtcttgaa t                                               21


<210>  2553
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2553
tggtggaagg kcctactgaa a                                               21


<210>  2554
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2554
caaatgactc wgattagacc a                                               21


<210>  2555
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2555
ggcctctgga wctatgagag a                                               21


<210>  2556
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2556
gtattgtttt yacttacacc a                                               21


<210>  2557
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2557
tgtgccacca mcttttttaa t                                               21


<210>  2558
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2558
aaaaaagttc kaagagggaa g                                               21


<210>  2559
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2559
taggctaaga rtatttttaa g                                               21


<210>  2560
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2560
acctaggcta stcacctttg g                                               21


<210>  2561
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2561
ttagtaaaat raaagcccat c                                               21


<210>  2562
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2562
ccagagtctg rttgaggata a                                               21


<210>  2563
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2563
ataaagaggt rgtaacatca a                                               21


<210>  2564
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2564
caaattggcc kgacaaaggt c                                               21


<210>  2565
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2565
gaaataattt rtgaattttg t                                               21


<210>  2566
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2566
atgttgttcc sttctctttt g                                               21


<210>  2567
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2567
tcactcgaaa saccttctcc a                                               21


<210>  2568
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2568
acagttgcct yatgacctgg a                                               21


<210>  2569
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2569
aaaaggctca rgcaggcagg g                                               21


<210>  2570
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2570
tctcttgact satgttacac a                                               21


<210>  2571
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2571
tgaagcacag ygttggcctg c                                               21


<210>  2572
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2572
taaggatcgt ytgcagaggc c                                               21


<210>  2573
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2573
gcagatattc ratctaattg c                                               21


<210>  2574
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2574
tgggagcact rgggacatgt c                                               21


<210>  2575
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2575
caaagagctc yacatttgac a                                               21


<210>  2576
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2576
acagggctga ktcatggtga c                                               21


<210>  2577
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2577
ctggccttgc ycagtcctca g                                               21


<210>  2578
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2578
gcaaaatttc sagccccatc c                                               21


<210>  2579
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2579
gccctaatcc ytttctaagg c                                               21


<210>  2580
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2580
taaagataaa ygagtacagt g                                               21


<210>  2581
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2581
cctgatccaa rggtgatgct c                                               21


<210>  2582
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2582
gcccatgaac yctgtggacc t                                               21


<210>  2583
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2583
atgcatgtat rttgcatatg c                                               21


<210>  2584
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2584
tagttgtgag maaagcacag c                                               21


<210>  2585
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2585
cattagtggt rtagcctatg c                                               21


<210>  2586
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2586
tgatatatat rtaggcccta g                                               21


<210>  2587
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2587
gcttccccag mggccttgct g                                               21


<210>  2588
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2588
acattttccc matgtgtcaa c                                               21


<210>  2589
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2589
tctgtgtctc yctttatggt a                                               21


<210>  2590
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2590
gattatctac ygccaaggcg c                                               21


<210>  2591
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2591
cccaggatta ycattccact g                                               21


<210>  2592
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2592
gctttgacca kcacaaccct t                                               21


<210>  2593
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2593
ttgttagtgt wccttaaagg c                                               21


<210>  2594
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2594
tctatatcaa ycaacataaa t                                               21


<210>  2595
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2595
ttttcccttt waatagcctc c                                               21


<210>  2596
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2596
taatatggct stttcataaa a                                               21


<210>  2597
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2597
cacttgtcca yctcctttct a                                               21


<210>  2598
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2598
acctttaatc stgcgtcccc c                                               21


<210>  2599
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2599
tctcttgcca sgtagcccac t                                               21


<210>  2600
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2600
atagaggttg rgtcaggagt g                                               21


<210>  2601
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2601
aacccagatc kttccctgca a                                               21


<210>  2602
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2602
gcctcctgct rtcctggcaa g                                               21


<210>  2603
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2603
ctatgaccca ytgagtaaaa g                                               21


<210>  2604
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2604
aaaaattaaa rcattgtgaa g                                               21


<210>  2605
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2605
tctcccctgc rtgttgcgtt g                                               21


<210>  2606
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2606
aagattttcc rggaagttgt c                                               21


<210>  2607
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2607
ggtcagggtc wtgtaggtgc t                                               21


<210>  2608
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2608
ctggtctcct ygtcagtcct c                                               21


<210>  2609
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2609
ccgtgttgca yattagagac t                                               21


<210>  2610
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2610
atcagtccag scatttgacc t                                               21


<210>  2611
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2611
gttagcctct rccgtggtgc t                                               21


<210>  2612
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2612
cggggaagac rttttggagc a                                               21


<210>  2613
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2613
gcttgaaaaa yggcagctgg t                                               21


<210>  2614
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2614
ggtgcgtaat rtaaaacatg g                                               21


<210>  2615
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2615
ccaggtgctt kagaagtttg c                                               21


<210>  2616
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2616
ttctgtccag ytgcttttgc t                                               21


<210>  2617
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2617
ggataagtca ktcgcacaag g                                               21


<210>  2618
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2618
caatcacccc wtaaacataa c                                               21


<210>  2619
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2619
ggtgatgaaa mgaacgtgga t                                               21


<210>  2620
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2620
cctccgtggc scatgcattc t                                               21


<210>  2621
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2621
gacaccgcac rgtaagcaga t                                               21


<210>  2622
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2622
ttgttgtttt yagttgtttg g                                               21


<210>  2623
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2623
tcagtgattc wagagagaaa g                                               21


<210>  2624
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2624
aattttttag rgcatctgga g                                               21


<210>  2625
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2625
attataacac rgtacatggg t                                               21


<210>  2626
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2626
gtcacctggg raaatcttgg t                                               21


<210>  2627
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2627
agaaagtaaa ygcaacacag t                                               21


<210>  2628
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2628
tacaggatag yttcctccta t                                               21


<210>  2629
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2629
gttgctgtaa kaaatgtgaa c                                               21


<210>  2630
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2630
taaaattgtc rttgctggaa a                                               21


<210>  2631
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2631
tctctgtgaa ygttaccagc t                                               21


<210>  2632
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2632
acctaataca rgagtcacta a                                               21


<210>  2633
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2633
agaatagcat rtgtaataaa c                                               21


<210>  2634
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2634
gtaagtagat rgagaaaagc c                                               21


<210>  2635
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2635
attcatcaca raagtaggaa g                                               21


<210>  2636
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2636
atttcaagac ygaacaggag t                                               21


<210>  2637
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2637
cttaatgagg ygaccatgag t                                               21


<210>  2638
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2638
agcatgggac rtctctgcct a                                               21


<210>  2639
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2639
gaacttcctc yttggaggct t                                               21


<210>  2640
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2640
cccagctcca ygttcacccc c                                               21


<210>  2641
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2641
caggaacaac rgctccttca t                                               21


<210>  2642
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2642
ttctgaattc rcatctcaat a                                               21


<210>  2643
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2643
tggagcactc rctactggtg a                                               21


<210>  2644
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2644
tatgtggcac ktcataaaaa a                                               21


<210>  2645
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2645
ttgattagta yggcattaga a                                               21


<210>  2646
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2646
agatacgtag raagaaagtc g                                               21


<210>  2647
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2647
gaaaagcata sgagggaaat g                                               21


<210>  2648
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2648
tcatttggaa rtagttttga g                                               21


<210>  2649
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2649
aagtatgcca ratgtattcc t                                               21


<210>  2650
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2650
gcatctgtaa ktccactgct t                                               21


<210>  2651
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2651
atcataaaaa rttagctgat a                                               21


<210>  2652
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2652
gtgtcttaac yctgagcata t                                               21


<210>  2653
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2653
atttatggag ktatccacta a                                               21


<210>  2654
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2654
gagaaaatcc rtcaagttga c                                               21


<210>  2655
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2655
aggatgtata magaagaatg t                                               21


<210>  2656
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2656
atatgatcgc ytgcttcctc c                                               21


<210>  2657
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2657
aatgatttac rttcagatta c                                               21


<210>  2658
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2658
ttggtttaca ygggctctag a                                               21


<210>  2659
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2659
cttcagtgct yagccaggcc a                                               21


<210>  2660
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2660
atttcaaact kagattaggt g                                               21


<210>  2661
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2661
tctaaccaac mtgacattgc t                                               21


<210>  2662
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2662
atacatgtac wcacagtgta t                                               21


<210>  2663
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2663
ttcatacacc sagcgtggat t                                               21


<210>  2664
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2664
tttcacacaa saataaagag a                                               21


<210>  2665
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2665
ctgttatacc rcaactgcta t                                               21


<210>  2666
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2666
gtcgaaacaa waatggcgga t                                               21


<210>  2667
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2667
aggggaacca rctcctggac a                                               21


<210>  2668
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2668
gaagacattt rgaagtcaca g                                               21


<210>  2669
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2669
aatgaaccac yacatcctgg t                                               21


<210>  2670
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2670
cgtaggaata matcaacagg a                                               21


<210>  2671
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2671
ctggtgacca ytgttccact c                                               21


<210>  2672
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2672
aggtcttaac yctagctcat c                                               21


<210>  2673
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2673
agtaatccta macatttgta t                                               21


<210>  2674
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2674
ggcaacaagt yaccatctta g                                               21


<210>  2675
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2675
atgtgcactt wgatacagca c                                               21


<210>  2676
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2676
gcagtggcag raggggtgag c                                               21


<210>  2677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2677
caccattacc rtaaatacat c                                               21


<210>  2678
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2678
ataccgttcc rggcagccct c                                               21


<210>  2679
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2679
ggtgcaataa rgtccaagtt g                                               21


<210>  2680
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2680
gagaagcaga wgacaggctc a                                               21


<210>  2681
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2681
tccatgcatt stttgtaaca g                                               21


<210>  2682
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2682
tctaataact mcaactgtgg a                                               21


<210>  2683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2683
tcataccttt raacatgtat c                                               21


<210>  2684
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2684
tcctcgctaa rcacagacac a                                               21


<210>  2685
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2685
cagatttaaa ytttcagtga c                                               21


<210>  2686
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2686
acatatgtat ratttacagt a                                               21


<210>  2687
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2687
agccaacagc ragaattaca t                                               21


<210>  2688
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2688
gaaactaaat rccttcatca g                                               21


<210>  2689
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2689
tgcagtgata ytgaaacacc a                                               21


<210>  2690
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2690
gctctgcagc ygtgggtttc t                                               21


<210>  2691
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2691
aggtagaaga saactgtaag t                                               21


<210>  2692
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2692
gtaaaatttg rtaattaaca a                                               21


<210>  2693
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2693
gtcacattta yggataagtt a                                               21


<210>  2694
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2694
caagcatttt wggtaaattg a                                               21


<210>  2695
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2695
tgaagaggct kccctgccaa a                                               21


<210>  2696
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2696
atgtcaacta yctcttctgt t                                               21


<210>  2697
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2697
acctacagat ktccctaatt t                                               21


<210>  2698
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2698
ccactttttt rgaaccttag t                                               21


<210>  2699
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2699
gatgacagcc ratgacagta a                                               21


<210>  2700
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2700
gtagacctgc rccttagttc c                                               21


<210>  2701
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2701
cattgacatc rgtcgagtca c                                               21


<210>  2702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2702
gtgacttctg ytctgcctag c                                               21


<210>  2703
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2703
aatataaatc ratttagggc a                                               21


<210>  2704
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2704
cttgtaaata ygctatctct a                                               21


<210>  2705
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2705
gtgtgtgtgg sttcacccag t                                               21


<210>  2706
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2706
cattttgcgc rattaggaaa c                                               21


<210>  2707
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2707
aaatgcacaa ytatataaca t                                               21


<210>  2708
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2708
ggggagacag raaggaaatg a                                               21


<210>  2709
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2709
aggctagtga ygttgagcat a                                               21


<210>  2710
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2710
taaccactta ytttgtaata c                                               21


<210>  2711
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2711
tttgacataa yggcattttt c                                               21


<210>  2712
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2712
attaactctt yaccaaacaa g                                               21


<210>  2713
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2713
tgttcatctc yaggactggg t                                               21


<210>  2714
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2714
gctgtggatg rcatcacatc t                                               21


<210>  2715
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2715
ctaaagggta mctcaaaaat c                                               21


<210>  2716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2716
ttgccctgaa ygcctagagt t                                               21


<210>  2717
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2717
ggtaggctcc raggagagtg a                                               21


<210>  2718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2718
atgagagaca rgtcattaag c                                               21


<210>  2719
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2719
accttgattg ytgactcaca g                                               21


<210>  2720
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2720
gccacaatca yggcaaaaac t                                               21


<210>  2721
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2721
tcacacagaa rgacaaacct g                                               21


<210>  2722
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2722
tttccttcaa kttccttgtt t                                               21


<210>  2723
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2723
catatcttat rtaattgcta a                                               21


<210>  2724
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2724
gctggcattc rtgatttggt t                                               21


<210>  2725
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2725
cattagggtt wtatcatttg c                                               21


<210>  2726
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2726
gagttcactc raagttctca c                                               21


<210>  2727
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2727
ttaactccac raaactattc c                                               21


<210>  2728
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2728
tccacaggtc rgtctataag c                                               21


<210>  2729
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2729
agagtgaatc raatatttta c                                               21


<210>  2730
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2730
atataacaga rgcaacctga c                                               21


<210>  2731
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2731
ttgggccaag yttaaatcag c                                               21


<210>  2732
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2732
attataatca ygtctcaaag c                                               21


<210>  2733
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2733
ctaattgtac ktcatttgca a                                               21


<210>  2734
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2734
tggctattgc rcttctttag a                                               21


<210>  2735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2735
tcttccactt mgcaatacca c                                               21


<210>  2736
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2736
tatgctaaga ragattaaat t                                               21


<210>  2737
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2737
aggggctggc mgttgaggat c                                               21


<210>  2738
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2738
atcactgaac ygtttgcatt a                                               21


<210>  2739
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2739
cagagtttaa stggggcttc c                                               21


<210>  2740
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2740
tcagcattta rcaaggcagt a                                               21


<210>  2741
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2741
gaagactgca stggttgctg c                                               21


<210>  2742
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2742
aaatgcacat rgaaggagaa a                                               21


<210>  2743
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2743
gtggaggtgc yctgctacag g                                               21


<210>  2744
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2744
ttgtacattc ytcctgtggt t                                               21


<210>  2745
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2745
gcagatgaat yccacccaga t                                               21


<210>  2746
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2746
ctgtgatgat sgagtgaact c                                               21


<210>  2747
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2747
agagccagat ytggattcaa g                                               21


<210>  2748
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2748
gctggatgtc rgagttaagt g                                               21


<210>  2749
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2749
ggaatatttt kctttagcaa c                                               21


<210>  2750
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2750
cattcattgc ragccagatg g                                               21


<210>  2751
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2751
ctaacaaaag stgtccccaa c                                               21


<210>  2752
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2752
aaaagttatc rgacttatca a                                               21


<210>  2753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2753
agagtagtct rgggaaagct t                                               21


<210>  2754
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2754
tagagcagca ygatccatct c                                               21


<210>  2755
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2755
aacacaagtc scagtcattg c                                               21


<210>  2756
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2756
ttttaagaaa ytgtttatcc g                                               21


<210>  2757
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2757
gagactcatc rtatttacca c                                               21


<210>  2758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2758
agggtttctg rgcttaaaat g                                               21


<210>  2759
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2759
attcaaagaa ytggaagcat t                                               21


<210>  2760
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2760
tggtcagagg ygtagtactg a                                               21


<210>  2761
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2761
aaaagtacat rtattcaaag a                                               21


<210>  2762
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2762
cctgattagt sctaaaagtc c                                               21


<210>  2763
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2763
ccatcacaac kgatcaatat t                                               21


<210>  2764
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2764
gtagttttac yctctggaca t                                               21


<210>  2765
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2765
aggccatagg stgtactttg g                                               21


<210>  2766
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2766
gttctcacag ygctgaggat a                                               21


<210>  2767
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2767
tttcatctct ygatactcat t                                               21


<210>  2768
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2768
gtctgacata ygaaaggtaa t                                               21


<210>  2769
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2769
gaagtgacta yagaaatgaa c                                               21


<210>  2770
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2770
acccagattt ygtgccaaga a                                               21


<210>  2771
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2771
ttatgaccta rgaatcttac t                                               21


<210>  2772
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2772
gccaaatcta ytgggagcct c                                               21


<210>  2773
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2773
tgaatcctat rgtacaatga g                                               21


<210>  2774
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2774
gtacacacac rttagtgcat g                                               21


<210>  2775
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2775
tctctaagct kcttctttcc t                                               21


<210>  2776
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2776
gtagctcgtg yagagcctgg c                                               21


<210>  2777
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2777
caacttttgc mtgagatagg g                                               21


<210>  2778
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2778
agctgtacca ygacaccact c                                               21


<210>  2779
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2779
tggctctgat staggtctcc c                                               21


<210>  2780
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2780
tcacgttgaa yactcatagc a                                               21


<210>  2781
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2781
tctatccaca yggcaaagct c                                               21


<210>  2782
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2782
aggtttgtat ragagttaaa t                                               21


<210>  2783
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2783
gtaaattcag rctgttaacg a                                               21


<210>  2784
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2784
tgtcagtgcc rtgtgttact t                                               21


<210>  2785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2785
aacaaagcca rtaagaccct g                                               21


<210>  2786
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2786
caaatttctg ygtcttagaa t                                               21


<210>  2787
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2787
gtttagggcc rtgataagaa a                                               21


<210>  2788
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2788
agtacttgcc rtggaactag a                                               21


<210>  2789
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2789
tatagagtga ycagagtgat a                                               21


<210>  2790
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2790
tatcaaactt yctgaaattc t                                               21


<210>  2791
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2791
gccagaacca sttagttgaa c                                               21


<210>  2792
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2792
atttgagcta ytgatcctgt t                                               21


<210>  2793
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2793
actaggcata ygggggaaaa g                                               21


<210>  2794
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2794
ggtttgaaga rgaaggaagg a                                               21


<210>  2795
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2795
gcttgtccta wttatttagc a                                               21


<210>  2796
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2796
caagataagg wtggtgagaa a                                               21


<210>  2797
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2797
tgtagtttgc ygtatcatcc a                                               21


<210>  2798
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2798
ctagtttgaa rgttctctga g                                               21


<210>  2799
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2799
tggataatga yagaaatgaa t                                               21


<210>  2800
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2800
tgtttgtcac ygcaagttcc t                                               21


<210>  2801
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2801
aagggtccag kaagggcctg g                                               21


<210>  2802
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2802
atctgagcca saggtgacca t                                               21


<210>  2803
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2803
aatttggaaa mctgtagggc t                                               21


<210>  2804
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2804
agatttgcat ragagaaaag c                                               21


<210>  2805
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2805
gacactagca ragaaagtca a                                               21


<210>  2806
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2806
actcgtagta ygaaactctt c                                               21


<210>  2807
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2807
tgaaaattca yctacatctt c                                               21


<210>  2808
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2808
acctgcttca rgtagaaacc a                                               21


<210>  2809
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2809
aagaccctta ygtgtatgta t                                               21


<210>  2810
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2810
agcaggcctt watgcatttg t                                               21


<210>  2811
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2811
gcattcttga raaataacat t                                               21


<210>  2812
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2812
ttacactcct wagtcttgct t                                               21


<210>  2813
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2813
gaagtttttt mtgacaatga a                                               21


<210>  2814
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2814
acattcgaac rgaacactgc c                                               21


<210>  2815
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2815
ttgtccaacc ycataaaatt t                                               21


<210>  2816
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2816
ataaccaaat kaagtcagta t                                               21


<210>  2817
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2817
ctttctcatt mtcaaatata c                                               21


<210>  2818
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2818
attttgccag yatgtccaat a                                               21


<210>  2819
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2819
ggcagcagga kgctggcatg t                                               21


<210>  2820
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2820
ataagcttct raggaacttc a                                               21


<210>  2821
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2821
gttacaagaa rcagaccaat g                                               21


<210>  2822
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2822
tcaacacata ytgaattact g                                               21


<210>  2823
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2823
cttttgttct rtattaatct t                                               21


<210>  2824
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2824
taaaggaatg yctctgtaac t                                               21


<210>  2825
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2825
tggaattttc waactgaagt g                                               21


<210>  2826
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2826
aataaaaggg rcatctctca c                                               21


<210>  2827
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2827
tcttcgagta rattctgaca c                                               21


<210>  2828
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2828
gctttaattt yctaaaagtc t                                               21


<210>  2829
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2829
aactctaatg satctaattt a                                               21


<210>  2830
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2830
tatgactgca ytggtcccca a                                               21


<210>  2831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2831
ctgaacctta wgctttggga t                                               21


<210>  2832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2832
gtaatgaatg wtcttcaatc a                                               21


<210>  2833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2833
tttaaatata yagcaagtag a                                               21


<210>  2834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2834
tacaccatca ytgtgggtga c                                               21


<210>  2835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2835
ttaaggacct mtccctaacg a                                               21


<210>  2836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2836
ccctgatacc rcctttgaaa a                                               21


<210>  2837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2837
aactaacaaa kaaaacccca a                                               21


<210>  2838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2838
caaggttcat waatttaagg c                                               21


<210>  2839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2839
ataagcactg ytgatcttaa a                                               21


<210>  2840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2840
tgcctcacat mcatggttca a                                               21


<210>  2841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2841
ggttgattat ygcaaacaga t                                               21


<210>  2842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2842
tttattttac mtgaaagcgc a                                               21


<210>  2843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2843
gtgcctacaa rtaccgggaa a                                               21


<210>  2844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2844
tgttccccat rgtcatttgg t                                               21


<210>  2845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2845
atgcatttac rtaagcttta a                                               21


<210>  2846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2846
agggctctgc rcttgaactt c                                               21


<210>  2847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2847
aatatatgtt sttagagtta t                                               21


<210>  2848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2848
cttagaagag rccatatatg a                                               21


<210>  2849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2849
tgctaaacag yatgaagact a                                               21


<210>  2850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2850
ctaccctact yatcataatg g                                               21


<210>  2851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2851
ccttttcttc ratattgtga t                                               21


<210>  2852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2852
tttttaggca ygtgaactga t                                               21


<210>  2853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2853
aacaccaaga rtgctggtaa g                                               21


<210>  2854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2854
gtgctctttt stcagtgttt t                                               21


<210>  2855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2855
tagagaaggg kacaagccat t                                               21


<210>  2856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2856
agaattgtga yattttagtt c                                               21


<210>  2857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2857
tgagccttag rgatccaatt t                                               21


<210>  2858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2858
agaatagtaa rgatgttaaa a                                               21


<210>  2859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2859
aggtaaagta ygttgaataa t                                               21


<210>  2860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2860
gaatcccaca rtgaacttgc a                                               21


<210>  2861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2861
attctaaaac rttaggagac a                                               21


<210>  2862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2862
agcctgtcta yctactggca t                                               21


<210>  2863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2863
ctcagtgatc rcacatagta g                                               21


<210>  2864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2864
gccaggtatt kttcagaatt c                                               21


<210>  2865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2865
cttgcttcta magacatgtg a                                               21


<210>  2866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2866
taaggaacga yagaaaggct g                                               21


<210>  2867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2867
gaagcattta rcgctatccc t                                               21


<210>  2868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2868
agaaccctta ygctaacctg a                                               21


<210>  2869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2869
aatgtgatct yctccacttc a                                               21


<210>  2870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2870
gattattgct yagtaattgt t                                               21


<210>  2871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2871
tcagacagac ytgcttgggg t                                               21


<210>  2872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2872
agaaaataaa rtggtatcaa a                                               21


<210>  2873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2873
tcaccatgta matatcttaa a                                               21


<210>  2874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2874
cacagcacat yccttcaatg a                                               21


<210>  2875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2875
acagagtctc rtcaggtccc t                                               21


<210>  2876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2876
taaaaatctc ytgaataatc t                                               21


<210>  2877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2877
cgaagccctt ycatgattct c                                               21


<210>  2878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2878
ccagaaatct yctttgactc a                                               21


<210>  2879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2879
aacagggtca stcaggttcc t                                               21


<210>  2880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2880
aattttggaa rgcattggaa t                                               21


<210>  2881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2881
attctttgat ytgacacaat c                                               21


<210>  2882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2882
aaaataaaga sctgtggctg c                                               21


<210>  2883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2883
ggtggtatct saaagtatca a                                               21


<210>  2884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2884
ttgtttcata wttttcctac a                                               21


<210>  2885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2885
gattgtgtcc kgctattatc t                                               21


<210>  2886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2886
ccttgcatct ygccagtata t                                               21


<210>  2887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2887
tgcgctcccg ytgctcctcc t                                               21


<210>  2888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2888
tctctggtag stggagtgtg g                                               21


<210>  2889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2889
atttgatgaa sagtcacaaa t                                               21


<210>  2890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2890
agtttattcc ygctgggtgt c                                               21


<210>  2891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2891
acttcaaata yggctgtgtc c                                               21


<210>  2892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2892
tagggcccac ygccagaaaa t                                               21


<210>  2893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2893
aacggtaaac rcatggtcta g                                               21


<210>  2894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2894
tgatactatc mttcgtgcac c                                               21


<210>  2895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2895
gttcatcagt rtctctctag a                                               21


<210>  2896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2896
cttcacgatg ygtctcttag a                                               21


<210>  2897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2897
aagctgttct ragattccac g                                               21


<210>  2898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2898
tccaagctgg rccttgagtg t                                               21


<210>  2899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2899
acgtgctgga ygctttgcct a                                               21


<210>  2900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2900
tgggaagcaa ygggaggtga g                                               21


<210>  2901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2901
tctcttacaa rgtcatctta c                                               21


<210>  2902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2902
tatcatcgga wtggtactgc c                                               21


<210>  2903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2903
actacaacga yaacaacaaa a                                               21


<210>  2904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2904
gagaattcca ktgcttatag g                                               21


<210>  2905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2905
aaaatacaga ragtattttg g                                               21


<210>  2906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2906
taggatttga rtgtaagcat t                                               21


<210>  2907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2907
cagtgtaagc rttcagaatg a                                               21


<210>  2908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2908
gcagtttatt yacattattt a                                               21


<210>  2909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2909
gaacaaagaa yacttatttt t                                               21


<210>  2910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2910
cagtgcctca rtaatactcc t                                               21


<210>  2911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2911
tattcagaat rgcagtgtaa a                                               21


<210>  2912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2912
gaagccactc kcttttcacc t                                               21


<210>  2913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2913
aagtggcacc rgacaagggg a                                               21


<210>  2914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2914
aggccatagg wcaggacatt t                                               21


<210>  2915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2915
tcaaataacc rtattttatt c                                               21


<210>  2916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2916
tgatgagcct sattcatctt t                                               21


<210>  2917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2917
ctgtggctac rgcactcagc a                                               21


<210>  2918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2918
ctaccattgg mtctcatggc t                                               21


<210>  2919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2919
gtgatgaaca scttcttcct c                                               21


<210>  2920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2920
aagactgtat stttcatagc a                                               21


<210>  2921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2921
ggtctggggt ygagaagtca c                                               21


<210>  2922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2922
gtgaaatagt wtccattgca t                                               21


<210>  2923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2923
aatgaaaaca ytgaacccac t                                               21


<210>  2924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2924
ctgttttacc rtgcaccagt t                                               21


<210>  2925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2925
aataggtggt rgtcatatct c                                               21


<210>  2926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2926
acttcactgt ygggtaaaac a                                               21


<210>  2927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2927
gtgcggccca wctgaaggag t                                               21


<210>  2928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2928
actgttggga katttacctg t                                               21


<210>  2929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2929
gcatatagtg rctatcccag a                                               21


<210>  2930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2930
gcaaaattag ycacactaaa a                                               21


<210>  2931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2931
aagggtaata wactttactc a                                               21


<210>  2932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2932
catttttaaa ycttagcagg t                                               21


<210>  2933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2933
gcacatagct rgatgttaaa c                                               21


<210>  2934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2934
gccacactga yggttgttag a                                               21


<210>  2935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2935
ataaagatgg yccttaaact t                                               21


<210>  2936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2936
taagcatgct stcgcacaca t                                               21


<210>  2937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2937
ttttttatac rcagagaagg a                                               21


<210>  2938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2938
tatggctccc magtggagat g                                               21


<210>  2939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2939
gtcttaatag rtatcagaca c                                               21


<210>  2940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2940
atcagtatat rttaaatcca c                                               21


<210>  2941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2941
taggtgagaa sagccctggg g                                               21


<210>  2942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2942
aattaatata ygtaagatgt t                                               21


<210>  2943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2943
tcataaaaga mcttgagagc c                                               21


<210>  2944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2944
catctgtgcc ygtgacaatg t                                               21


<210>  2945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2945
agacctgtta kgcaggtata a                                               21


<210>  2946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2946
ggagccgaca yagagagctg t                                               21


<210>  2947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2947
cttgacgcag rgtagagaaa g                                               21


<210>  2948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2948
tcacgaaaac rtaactgagt t                                               21


<210>  2949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2949
ttaacagtcc yctccagtta a                                               21


<210>  2950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2950
aatacgatga yaataaggct c                                               21


<210>  2951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2951
acacaaaggg wgtacatcta c                                               21


<210>  2952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2952
cgctattgca rtgccacgtg a                                               21


<210>  2953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2953
ttcatagaca raagtaagtc a                                               21


<210>  2954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2954
agaccttcat rcggtgacga t                                               21


<210>  2955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2955
agtggatgag rgattcttat g                                               21


<210>  2956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2956
cttcccgtgg sacagaactt t                                               21


<210>  2957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2957
acgtccttgc rgatgacttc c                                               21


<210>  2958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2958
tgtcaagcca rtaatctccc a                                               21


<210>  2959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2959
atgtagtatg ygttacattt c                                               21


<210>  2960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2960
ctggccaaga yattggtcac t                                               21


<210>  2961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2961
cttttttcgg ygtatcaccc c                                               21


<210>  2962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2962
ctttacaagc watactttct g                                               21


<210>  2963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2963
gcatcatttc yggtgtaggc a                                               21


<210>  2964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2964
ggcactgcgt ytttctgtcc t                                               21


<210>  2965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2965
gctgaaactt rgccacaaat a                                               21


<210>  2966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2966
tgacttttta ktcttgaaac c                                               21


<210>  2967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2967
ttgtgtctta wattcatggg c                                               21


<210>  2968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2968
tgtccatgca ygtacagagt t                                               21


<210>  2969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2969
tatgtcccaa ytcacaatgg t                                               21


<210>  2970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2970
acctatgcac rtttttatca t                                               21


<210>  2971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2971
aagtgatgaa yagcataaac t                                               21


<210>  2972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2972
gaaaagccat ygtgttgaag t                                               21


<210>  2973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2973
atcagtagtg yacttgaaaa t                                               21


<210>  2974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2974
ccttagcaac mctttcatat c                                               21


<210>  2975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2975
gcctctttaa yatggatgca a                                               21


<210>  2976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2976
ctccattgaa ytgtgaagag a                                               21


<210>  2977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2977
tcatattgcc rgctgctccc t                                               21


<210>  2978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2978
taactgttat ytttgttgcc a                                               21


<210>  2979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2979
tttggtgtgc mggccaattt t                                               21


<210>  2980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2980
gcattttttt rtaacagccc a                                               21


<210>  2981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2981
taagtagtaa rataaaaata a                                               21


<210>  2982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2982
tgttgaagat yaaagataat a                                               21


<210>  2983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2983
aaggatcaaa mcagtggagc a                                               21


<210>  2984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2984
taccaagtag katatttgtg a                                               21


<210>  2985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2985
cctcctctta rtagacctac t                                               21


<210>  2986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2986
ttaaataaag sgtggattgg g                                               21


<210>  2987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2987
attgcatgat ygtatcagat g                                               21


<210>  2988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2988
atatagtagt kaagaaccct a                                               21


<210>  2989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2989
aaaagagtcc racaaggaaa a                                               21


<210>  2990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2990
gactctaaga ktaaggaata g                                               21


<210>  2991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2991
tgacatatac rttagccctt a                                               21


<210>  2992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2992
gatctagtgt sctctcaaaa t                                               21


<210>  2993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2993
accatgcccc rggtcctgtg c                                               21


<210>  2994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2994
atggaaaaca yggaaaggag a                                               21


<210>  2995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2995
aagttaagac yacattccta t                                               21


<210>  2996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2996
agatcacttt ktatggacat t                                               21


<210>  2997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2997
caggagttcc rttaagtatc a                                               21


<210>  2998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2998
caaccagcag wttatgattt a                                               21


<210>  2999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  2999
atgactttgg wctgttccaa a                                               21


<210>  3000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3000
aatcatttca raaaggtatt a                                               21


<210>  3001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3001
acattcctgt yagagcactt a                                               21


<210>  3002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3002
ctctgccaag rttccatgta g                                               21


<210>  3003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3003
atggtgagaa sgtacaacca g                                               21


<210>  3004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3004
gcatctccaa yaaaatacaa g                                               21


<210>  3005
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3005
agtaattgcc rttgaggaaa g                                               21


<210>  3006
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3006
gttacttcta rgcaccttca g                                               21


<210>  3007
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3007
ctgaatgccc wcacaggacc a                                               21


<210>  3008
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3008
catgtgactt yggaaatgca t                                               21


<210>  3009
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3009
attacactac mgcagtgagc c                                               21


<210>  3010
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3010
ggttccagat yggtggatcc a                                               21


<210>  3011
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3011
tgggctccca yagcacccag a                                               21


<210>  3012
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3012
tggttaaggc watttttaga t                                               21


<210>  3013
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3013
ttaaacaaaa ytggatgcaa g                                               21


<210>  3014
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3014
ttccagactt ygggagcctt c                                               21


<210>  3015
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3015
ggaggatctc rtgaaatcag g                                               21


<210>  3016
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3016
acagagtata scaaaaacat c                                               21


<210>  3017
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3017
gtaggagaag wgaaatcgtc t                                               21


<210>  3018
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3018
aaggacacag ygtatcaaac c                                               21


<210>  3019
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3019
ttgttctagg ytccaagagc a                                               21


<210>  3020
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3020
tgccaaattc ygggctaaat t                                               21


<210>  3021
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3021
ggcagggatc rcaggtagca g                                               21


<210>  3022
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3022
tataagacat raaaatgaca a                                               21


<210>  3023
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3023
acatccatac rtttttaaga g                                               21


<210>  3024
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3024
ataattataa wtctagccaa t                                               21


<210>  3025
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3025
aagcagccaa rtaacagcta a                                               21


<210>  3026
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3026
actcagaatg magtcctcaa a                                               21


<210>  3027
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3027
aaataaccgt yatgcatttt g                                               21


<210>  3028
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3028
acatgttctg raatttgatc t                                               21


<210>  3029
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3029
aatgtcatcc rtaagttctt g                                               21


<210>  3030
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3030
acccaagtca rtcatggata t                                               21


<210>  3031
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3031
aatgaccttt sgtgtggcat g                                               21


<210>  3032
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3032
ggatattgtt ytttaatcct c                                               21


<210>  3033
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3033
ccaaagtcta rcttagctca a                                               21


<210>  3034
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3034
gaaaccagca ygcattagag c                                               21


<210>  3035
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3035
ccggagtaga rgaagaaaga g                                               21


<210>  3036
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3036
ggagactctt ragggatctg c                                               21


<210>  3037
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3037
cagttttttt watcttgctg g                                               21


<210>  3038
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3038
tgaatttgag ycacactggg a                                               21


<210>  3039
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3039
caacaatgca stttacacac t                                               21


<210>  3040
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3040
agacattttt ratggcgctg g                                               21


<210>  3041
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3041
ttttgtggga mtgcctttca c                                               21


<210>  3042
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3042
atttactaaa rccacgtaca t                                               21


<210>  3043
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3043
ccagacagtt sctttttaag a                                               21


<210>  3044
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3044
tccatgttta stgaagctgg g                                               21


<210>  3045
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3045
atctctccca sgttgtgaat g                                               21


<210>  3046
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3046
aggagggctg ygtcgggtaa t                                               21


<210>  3047
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3047
agacatacat yatccactca g                                               21


<210>  3048
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3048
cttactttaa yatgcccata a                                               21


<210>  3049
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3049
aaaccatata matttttaga a                                               21


<210>  3050
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3050
aacaggccct ycaaaattga t                                               21


<210>  3051
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3051
tccatcatca yggccaccct a                                               21


<210>  3052
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3052
taagagacag mtttcaacaa a                                               21


<210>  3053
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3053
cacagacgct yacaaggggc c                                               21


<210>  3054
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3054
tggaactagg wcctattgtg g                                               21


<210>  3055
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3055
ctacgccaca rtaataaaca c                                               21


<210>  3056
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3056
tggcctcttg mgtcttacag c                                               21


<210>  3057
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3057
ggttcacaga kctcagcatt a                                               21


<210>  3058
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3058
aacattatta saatcacttt a                                               21


<210>  3059
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3059
acttatcttc mtatttctta c                                               21


<210>  3060
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3060
tgtaattgtt kgtctcaact g                                               21


<210>  3061
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3061
tttaaaaaat ktaaatgtct g                                               21


<210>  3062
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3062
cagtgttctt yctggaaata a                                               21


<210>  3063
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3063
ataatacttc satttgactg c                                               21


<210>  3064
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3064
ggatatttgg rttccagtcc t                                               21


<210>  3065
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3065
tacattgatc rtgttgaaag g                                               21


<210>  3066
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3066
tgcagccaac yatcttaaaa g                                               21


<210>  3067
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3067
tcactctatc sctttaaatt a                                               21


<210>  3068
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3068
gtattgtaaa sattcaccct g                                               21


<210>  3069
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3069
ggctgattag yggagacggt c                                               21


<210>  3070
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3070
gacttggact saacaccatc a                                               21


<210>  3071
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3071
ggctttaaag ktaagagtaa t                                               21


<210>  3072
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3072
tatgctagct rctttgcagg t                                               21


<210>  3073
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3073
ttagatcaca rtgaaaagtt a                                               21


<210>  3074
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3074
taagaatgtt katggaaacc c                                               21


<210>  3075
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3075
ccagagaagc racgattctt a                                               21


<210>  3076
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3076
gcgtgaatac rtggagagcg t                                               21


<210>  3077
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3077
ctgctccaac yggcaggcaa g                                               21


<210>  3078
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3078
tggtttgtcc sccacaccat a                                               21


<210>  3079
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3079
tcattcctcc wtgtctgttt a                                               21


<210>  3080
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3080
aggcggggaa kggtattcca a                                               21


<210>  3081
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3081
tcgacaagcc rccgagttca a                                               21


<210>  3082
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3082
cagagtcgca saggatcggg g                                               21


<210>  3083
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3083
accctggtac yagcagacat c                                               21


<210>  3084
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3084
cgcctcagac kgaggatccc c                                               21


<210>  3085
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3085
aatttctctc rttttgcaat a                                               21


<210>  3086
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3086
aatcagtcct ytctaaacgt g                                               21


<210>  3087
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3087
tcctagccca yagcgcccca a                                               21


<210>  3088
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3088
tcctgggaac mttgacaaga a                                               21


<210>  3089
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3089
gacaatggcc raggcataga t                                               21


<210>  3090
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3090
tcaagaagtc rgcaggggcc a                                               21


<210>  3091
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3091
cctgatatgt kggtataagt t                                               21


<210>  3092
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3092
gaagaaggag mcctctctaa g                                               21


<210>  3093
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3093
caaaaagtca rttgttgaag t                                               21


<210>  3094
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3094
ctccgctttt rgagtgtgtc t                                               21


<210>  3095
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3095
ggtttaatac ygtgcatgca a                                               21


<210>  3096
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3096
taagagacca ygaccatgtg t                                               21


<210>  3097
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3097
gcctttcaga ytgtgggcca c                                               21


<210>  3098
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3098
tgtttcatcc ktcaaagaag a                                               21


<210>  3099
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3099
atcccttcca ygcaagggct a                                               21


<210>  3100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3100
gaagagcaaa katgatgctg t                                               21


<210>  3101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3101
cgggagagat ktgatttacg a                                               21


<210>  3102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3102
tctcagtcac raatctagcc c                                               21


<210>  3103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3103
tttttttcct sagagtcagt g                                               21


<210>  3104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3104
agattcgaaa mtgcatggca g                                               21


<210>  3105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3105
cagcaaaaca sagtggctca g                                               21


<210>  3106
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3106
ctacacattt kaaaagtcat g                                               21


<210>  3107
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3107
gtattttcca ygctttctgt g                                               21


<210>  3108
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3108
tgtccctgct rtctggacgt c                                               21


<210>  3109
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3109
gtaatcacca yggaaagtgg c                                               21


<210>  3110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3110
tgacataaag rcatcaaaac c                                               21


<210>  3111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3111
gcttgagttt ktttcggttt t                                               21


<210>  3112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3112
gttagagaaa rttaaagaga g                                               21


<210>  3113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3113
gggcggtcat mctccacaca t                                               21


<210>  3114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3114
ttgaagtttc yatttaagat a                                               21


<210>  3115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3115
acacgtgcac rcagacagag a                                               21


<210>  3116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3116
tcctcctacc ratgactaaa a                                               21


<210>  3117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3117
gaggcgacca rtggcagata g                                               21


<210>  3118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3118
tgtgtccttt stcacagcat a                                               21


<210>  3119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3119
ttgtattagt ygctggtgtg t                                               21


<210>  3120
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3120
ttaaatcacc rctttatgaa t                                               21


<210>  3121
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3121
ggattgggtt rtatgtttct g                                               21


<210>  3122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3122
aacccttcat statgggccg a                                               21


<210>  3123
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3123
gtgggatcgt stagccttca t                                               21


<210>  3124
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3124
gagacccact kgataaaaac g                                               21


<210>  3125
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3125
cctccagaaa ycaccctgag a                                               21


<210>  3126
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3126
agatccatag ytggaaggaa g                                               21


<210>  3127
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3127
tggagtcact saggtaggtg g                                               21


<210>  3128
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3128
gcggtgcccg ygattgtctg a                                               21


<210>  3129
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3129
acggcattca rttcacattt g                                               21


<210>  3130
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3130
gacgccaatt rtacagatgc a                                               21


<210>  3131
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3131
ggttcagtat rgaattccca g                                               21


<210>  3132
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3132
gattaagttg wctaagcaag a                                               21


<210>  3133
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3133
gcatgcttgc rtagcccaga a                                               21


<210>  3134
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3134
agaagatagg ytcttgaatg t                                               21


<210>  3135
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3135
ttggaaaggg wctcaccagt t                                               21


<210>  3136
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3136
tcattgtttg ygtgcccttt a                                               21


<210>  3137
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3137
ttctgtaccg yggcctggga t                                               21


<210>  3138
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3138
ttcttcctgc racaaaagac c                                               21


<210>  3139
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3139
atggcaagac rgttaaaaca a                                               21


<210>  3140
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3140
gcctgggacc kcccagcccc a                                               21


<210>  3141
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3141
catgtttaaa yggcattctg t                                               21


<210>  3142
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3142
gtggtttcca yacctgggaa g                                               21


<210>  3143
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3143
gctgatacat matcgttact g                                               21


<210>  3144
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3144
gcatgtccaa ygtggaagga a                                               21


<210>  3145
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3145
agaaagactt wgaagaggag a                                               21


<210>  3146
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3146
gcccaagctg stcagctgag a                                               21


<210>  3147
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3147
ggacactaac rtcgggaggg a                                               21


<210>  3148
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3148
gagatggaac ygtaggccag g                                               21


<210>  3149
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3149
tattatctca ygtatgcttt g                                               21


<210>  3150
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3150
cccgagtcca macaccctat g                                               21


<210>  3151
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3151
tgccactccc rtgaagtggt g                                               21


<210>  3152
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3152
aggtgcagac rccccagctt c                                               21


<210>  3153
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3153
caggaaaggg raaggggcag t                                               21


<210>  3154
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3154
ggaacccaga rtggccaaag c                                               21


<210>  3155
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3155
tgcatttcca ygtagacact g                                               21


<210>  3156
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3156
tgccgggact yaaggtcagt g                                               21


<210>  3157
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3157
ttcagaacga rgatgacatg c                                               21


<210>  3158
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3158
agatcattca mataattttt a                                               21


<210>  3159
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3159
actgtggatt yagttggaag t                                               21


<210>  3160
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3160
gctgggagcc ygatctgaat g                                               21


<210>  3161
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3161
tcccaggatg scacatgcaa c                                               21


<210>  3162
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3162
gtaaaccccg ygatgaaggg c                                               21


<210>  3163
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3163
catatgtcag mcttcccctg a                                               21


<210>  3164
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3164
gaggaagcat yggagactgg g                                               21


<210>  3165
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3165
ctggctctgt rtatgcacgt g                                               21


<210>  3166
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3166
ctgtctccaa rtgagagtac g                                               21


<210>  3167
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3167
tctgtaaaaa wtttaagtga a                                               21


<210>  3168
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3168
agtaaaaaaa wttgagaatt c                                               21


<210>  3169
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3169
ttttcaaaga magtatacaa t                                               21


<210>  3170
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3170
tggtattgga rcacacattt a                                               21


<210>  3171
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3171
tgatttttac yactttttaa a                                               21


<210>  3172
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3172
agtctgaaaa yttaccgact c                                               21


<210>  3173
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3173
ccttggaaga ygagactacc c                                               21


<210>  3174
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3174
ctgagcacag yacataagag a                                               21


<210>  3175
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3175
cctttgacaa saataaggct g                                               21


<210>  3176
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3176
ttatttgtca mtctcacatc c                                               21


<210>  3177
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3177
tccatcccac rttctattaa a                                               21


<210>  3178
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3178
caattcttcc rtttactgcc c                                               21


<210>  3179
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3179
cccctgagac ygtaacagag a                                               21


<210>  3180
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3180
ggatttttga ragtcagagt a                                               21


<210>  3181
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3181
gcttcaggtc rtctcttcct t                                               21


<210>  3182
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3182
aattattgct mcagaaatca t                                               21


<210>  3183
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3183
gaacctgccg yaggatagct t                                               21


<210>  3184
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3184
catttgcttt yaggtatccc t                                               21


<210>  3185
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3185
acctaaccaa mgctttgtat t                                               21


<210>  3186
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3186
ggatatccta ygccacagac c                                               21


<210>  3187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3187
tttgaaagat wcaggttgat t                                               21


<210>  3188
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3188
tttgtgatag raatttttca g                                               21


<210>  3189
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3189
tacatacatt rctaaaaatg t                                               21


<210>  3190
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3190
gtgacaagtg ytttctttta t                                               21


<210>  3191
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3191
atgtgtcctg ycaggcacat t                                               21


<210>  3192
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3192
gttcctcacc rccattcgct c                                               21


<210>  3193
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3193
aaaatttgct maatagagtt a                                               21


<210>  3194
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3194
tcaacatgta stagagtgag g                                               21


<210>  3195
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3195
aagaaatcta mgaacactgg c                                               21


<210>  3196
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3196
aaatctgtat kaaagaggtt c                                               21


<210>  3197
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3197
atgcagatga ragacaccat t                                               21


<210>  3198
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3198
tctcttttga rtatgtcttt t                                               21


<210>  3199
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3199
aaagctgaac rttgacaacc t                                               21


<210>  3200
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3200
cgcctgagca wtctatccag a                                               21


<210>  3201
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3201
tgaccaactc ytgccccagt a                                               21


<210>  3202
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3202
aacactctgg rcctcctgcc a                                               21


<210>  3203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3203
cctctgcacc saagtgtgtg a                                               21


<210>  3204
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3204
tagacattgt rgcccgaatg t                                               21


<210>  3205
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3205
agagtgggca ygatgacctg a                                               21


<210>  3206
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3206
acgatggggc rtggggcttg g                                               21


<210>  3207
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3207
tcactttgac rgagtctctt g                                               21


<210>  3208
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3208
tgaattaaaa yagggctgtg t                                               21


<210>  3209
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3209
atttacatca wcggtttata a                                               21


<210>  3210
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3210
tcattgctta mtctctatgt a                                               21


<210>  3211
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3211
aatcaaaagc rtggtacccg g                                               21


<210>  3212
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3212
ggaacattct ytcttggttt a                                               21


<210>  3213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3213
gattttcaca wctttttcag t                                               21


<210>  3214
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3214
atcacctact kccagtaatt a                                               21


<210>  3215
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3215
atttctcaag kgaagaattc a                                               21


<210>  3216
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3216
atacacagag wtgattatat g                                               21


<210>  3217
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3217
tatctccctc yggttttctc c                                               21


<210>  3218
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3218
acttatgtct mttaaaataa a                                               21


<210>  3219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3219
ttttataatg mactaatgct t                                               21


<210>  3220
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3220
attttaatga wttagggtct t                                               21


<210>  3221
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3221
aaaatgacca rttaccatat t                                               21


<210>  3222
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3222
atgttgtatg ytaatttcca t                                               21


<210>  3223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3223
ggcagatgtc rtgaccagaa g                                               21


<210>  3224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3224
gatcccaaaa yaattgccat a                                               21


<210>  3225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3225
actattttcg watttactta t                                               21


<210>  3226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3226
cctgtaggat rtcattgagt c                                               21


<210>  3227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3227
ttggcacagg yattttagct c                                               21


<210>  3228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3228
atttggtaaa mcccagatgt a                                               21


<210>  3229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3229
agagaatggt rggtatcaca g                                               21


<210>  3230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3230
tccgccagtc rtagtgtttt c                                               21


<210>  3231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3231
ggaaaattcc ycaagatcta a                                               21


<210>  3232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3232
caaactttgc ygaaagcagc t                                               21


<210>  3233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3233
actctgatag ycatccaatc t                                               21


<210>  3234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3234
aagtgttgtg yatgactata c                                               21


<210>  3235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3235
ttgagaacta yattgttgta g                                               21


<210>  3236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3236
aaagacttca rtaatactgt c                                               21


<210>  3237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3237
atcaattgca yggaaatatt c                                               21


<210>  3238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3238
gcttttcatt yatcccatgt g                                               21


<210>  3239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3239
tctgtattca wctattcatt g                                               21


<210>  3240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3240
caataacata watcaaggca g                                               21


<210>  3241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3241
gaagatggtg ycatcctcca a                                               21


<210>  3242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3242
ccaaaataca wtctcatttt a                                               21


<210>  3243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3243
ctccaagaga wctatctggt c                                               21


<210>  3244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3244
caggctatac rttcagggat a                                               21


<210>  3245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3245
ccaggtactt yactcaagat t                                               21


<210>  3246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3246
gcgtagccaa yactcatcaa t                                               21


<210>  3247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3247
agctcccatc rctgccatat t                                               21


<210>  3248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3248
ccagaaagat yacaaataga c                                               21


<210>  3249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3249
ctataagttt sggaaaggaa a                                               21


<210>  3250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3250
aattcttctc rgatacaccc t                                               21


<210>  3251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3251
aaaagagcct yctagcccct t                                               21


<210>  3252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3252
gttaattctt ytcatagatt g                                               21


<210>  3253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3253
actgacataa ygtaaagcca t                                               21


<210>  3254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3254
ctatctttaa rctaaaaaaa c                                               21


<210>  3255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3255
aagtaaatca mctgtcttct a                                               21


<210>  3256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3256
gcttacacaa ytcctttacc t                                               21


<210>  3257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3257
ttacaatagc rgaaagttca g                                               21


<210>  3258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3258
taaaaccaaa yggcacaaat c                                               21


<210>  3259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3259
attgtttata yatttaatat g                                               21


<210>  3260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3260
attcttattt maaacagttt t                                               21


<210>  3261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3261
gtatgtgttc ygggttaatg t                                               21


<210>  3262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3262
gcaaattcag yttcttcctg a                                               21


<210>  3263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3263
actggattcc raagtttaga a                                               21


<210>  3264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3264
gtgtgaaaaa ratggcattg a                                               21


<210>  3265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3265
atgaactccc rggtttagga t                                               21


<210>  3266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3266
actttggaat maaaaaatag c                                               21


<210>  3267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3267
tctcaatcta ygtccacagg a                                               21


<210>  3268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3268
acctcagtta yagtgaagca a                                               21


<210>  3269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3269
gggcagtgtc rtcatctgtt c                                               21


<210>  3270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3270
ctaaagtgca rttttggaaa g                                               21


<210>  3271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3271
cagaagattc rcatggacat g                                               21


<210>  3272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3272
caaaaaggac rtccagcctt a                                               21


<210>  3273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3273
atgcaaggca kctgtaagag g                                               21


<210>  3274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3274
tttctagaga waaaatggac t                                               21


<210>  3275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3275
ttgaacctta ygttttggag g                                               21


<210>  3276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3276
aaggccttga ragctgccca a                                               21


<210>  3277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3277
cagttattat yggagaggag g                                               21


<210>  3278
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3278
agtaagagtc ygaggaattc a                                               21


<210>  3279
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3279
caggtccatg yagtgcaaag t                                               21


<210>  3280
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3280
acttcgtgat mtggccttag g                                               21


<210>  3281
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3281
ttgaggaacc yatcttgctg t                                               21


<210>  3282
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3282
agctagagat rtgtatggga t                                               21


<210>  3283
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3283
agatgtgatg wgtagtgaga t                                               21


<210>  3284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3284
gggcatcagg ratgttataa a                                               21


<210>  3285
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3285
aaagcaaaca yagtaccgag g                                               21


<210>  3286
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3286
ctgtaacaca satgttttgg t                                               21


<210>  3287
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3287
ccaggtaagg ytgtctttat t                                               21


<210>  3288
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3288
gggtagatgt sctaacgatt a                                               21


<210>  3289
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3289
ggattcaacc ytggttattt t                                               21


<210>  3290
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3290
ttttggcagc rtattcccag t                                               21


<210>  3291
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3291
gtacattgtt yaaaagagct g                                               21


<210>  3292
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3292
ctggacttcc ytcaaacgtg g                                               21


<210>  3293
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3293
gagttcaaga mcgactggac g                                               21


<210>  3294
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3294
aagtaggttt rcttaagccc a                                               21


<210>  3295
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3295
acttggaaaa yggacaggaa g                                               21


<210>  3296
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3296
agctgcaacc kacttggttt t                                               21


<210>  3297
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3297
ttatcaaatt yaacaaaaat t                                               21


<210>  3298
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3298
aatacaaact rtcttacagt g                                               21


<210>  3299
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3299
aagtgttcct mtgacaaaat a                                               21


<210>  3300
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3300
ataagagatt yctggtgcca a                                               21


<210>  3301
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3301
tcatttctga mcaaattggc c                                               21


<210>  3302
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3302
gaagcaagga mtcatctttt g                                               21


<210>  3303
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3303
ccaagtctca sagtgacatc a                                               21


<210>  3304
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3304
acgccataaa rtaggtttgc c                                               21


<210>  3305
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3305
ccccggaaat kggagtgaag c                                               21


<210>  3306
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3306
aaatcatttt yctacacggg a                                               21


<210>  3307
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3307
catacacacc ygtgttttat a                                               21


<210>  3308
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3308
gctgtgctgt rtcattgcag a                                               21


<210>  3309
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3309
gcagacagac stcacttact c                                               21


<210>  3310
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3310
aatgatttag satggagcac a                                               21


<210>  3311
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3311
gtattattcc rtcagccctt c                                               21


<210>  3312
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3312
ccgattggct yttggtatta a                                               21


<210>  3313
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3313
aagggaggac saggtgtcgc t                                               21


<210>  3314
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3314
taacttggtc rtgtgtgtgt g                                               21


<210>  3315
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3315
taatcaagaa yatcaggctt g                                               21


<210>  3316
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3316
agacaggcac yagcagacac a                                               21


<210>  3317
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3317
cctaggggat yggagttgga a                                               21


<210>  3318
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3318
tttggagccc ygtagaatca g                                               21


<210>  3319
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3319
tgcccttagg wtgcggaatt t                                               21


<210>  3320
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3320
ctcttcatct kttaacttct c                                               21


<210>  3321
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3321
gagttgcagg raaagtacag a                                               21


<210>  3322
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3322
tatagatacg yacatgttga c                                               21


<210>  3323
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3323
tcagaaaaac rtcacagagc c                                               21


<210>  3324
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3324
accaaactca rgatgaaaac a                                               21


<210>  3325
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3325
atggcacccg ytgcagaatg c                                               21


<210>  3326
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3326
aacagaagaa ygaattaccc a                                               21


<210>  3327
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3327
ggaacatatc yctgggtaat t                                               21


<210>  3328
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3328
aacaagctct rgaactgaaa t                                               21


<210>  3329
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3329
cactgaacta mccaggcttt a                                               21


<210>  3330
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3330
agctgccacg ytggaatttt t                                               21


<210>  3331
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3331
caatagaatc scaatttgta a                                               21


<210>  3332
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3332
gttatgatta ytgaaaaatt t                                               21


<210>  3333
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3333
cgcagaatga magccaacca g                                               21


<210>  3334
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3334
attgtgttgt saaatagttt t                                               21


<210>  3335
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3335
ttgtgagtgt ygtcagattc a                                               21


<210>  3336
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3336
gacagcattc ytttttccct c                                               21


<210>  3337
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3337
agctctcggt ycttactccc c                                               21


<210>  3338
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3338
gttcggagat rttcttaagc t                                               21


<210>  3339
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3339
actcgatgca ytgaaataag t                                               21


<210>  3340
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3340
caaagtccac rtcgtcttta a                                               21


<210>  3341
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3341
gcccttctgt ycactcttca a                                               21


<210>  3342
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3342
tcctaggcac rttatttact t                                               21


<210>  3343
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3343
ccagaacaaa ygcaactgcc t                                               21


<210>  3344
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3344
gcaaataatg stacactata t                                               21


<210>  3345
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3345
cacgtactca ytcctttgtg c                                               21


<210>  3346
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3346
agacttcctc rgagtgttgt t                                               21


<210>  3347
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3347
tcacgtcaag kcaaaaagaa a                                               21


<210>  3348
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3348
agatacaaat rcgtgtgctg a                                               21


<210>  3349
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3349
caatagtgct ygttcatcta t                                               21


<210>  3350
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3350
cagccatttg matctctgtg a                                               21


<210>  3351
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3351
tttatttgac raagttttgt t                                               21


<210>  3352
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3352
gcctgagttt sgctctgtct c                                               21


<210>  3353
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3353
gcgtcgcagc yccggtcccg g                                               21


<210>  3354
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3354
agacgtgagt yggccgatgc t                                               21


<210>  3355
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3355
gccaccatgt ygggcaactt t                                               21


<210>  3356
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3356
tctagctagg wcagccagta t                                               21


<210>  3357
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3357
cctactttac rcaaatcata g                                               21


<210>  3358
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3358
cactgtgatt rtagaaagtg t                                               21


<210>  3359
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3359
cttccaggct ygtggtagtc c                                               21


<210>  3360
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3360
ttggtttgca yagctagaaa g                                               21


<210>  3361
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3361
caacttcagg ragatgcccc t                                               21


<210>  3362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3362
ggaaaccatt wgtgacctgt a                                               21


<210>  3363
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3363
ctggtataag ktccctgaat t                                               21


<210>  3364
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3364
aaaaatgctt yagttaaaag a                                               21


<210>  3365
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3365
ctagggagac ygagcaaagc a                                               21


<210>  3366
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3366
ctgggaccca saagacctgg a                                               21


<210>  3367
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3367
ctgctcctaa mctctgaaat a                                               21


<210>  3368
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3368
atactgcacc ytaccctact g                                               21


<210>  3369
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3369
gagaagaagt yggggccagg t                                               21


<210>  3370
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3370
atgggaaatc ratgagactt g                                               21


<210>  3371
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3371
acgaactatt raaactaaaa g                                               21


<210>  3372
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3372
actctactac rgggttatct g                                               21


<210>  3373
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3373
agaaagttga wgcaatgtga a                                               21


<210>  3374
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3374
gtaacaaatg rttctaactg g                                               21


<210>  3375
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3375
cagacaagga kgtatgtggt g                                               21


<210>  3376
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3376
cccaaccagc rtatgtgtga a                                               21


<210>  3377
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3377
tatcttgatt yaaaaccagg a                                               21


<210>  3378
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3378
gagaacatta ygggcaatag a                                               21


<210>  3379
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3379
ctattgatga raagagagat g                                               21


<210>  3380
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3380
agatttggag yaggagttac a                                               21


<210>  3381
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3381
tagcaatttt ycccttcatt a                                               21


<210>  3382
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3382
aatgcccact rgatttgaag g                                               21


<210>  3383
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3383
aatcagtgaa rgaggtagga a                                               21


<210>  3384
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3384
tctggctctg rtaatagtta g                                               21


<210>  3385
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3385
tataattcag rgacatgagt g                                               21


<210>  3386
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3386
caggtggggc yttcttcctt c                                               21


<210>  3387
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3387
gtcagcttgc rctatgcaga a                                               21


<210>  3388
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3388
acggtccacc rtggacagag g                                               21


<210>  3389
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3389
aaataagcgc racggaggga g                                               21


<210>  3390
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3390
tgaatgtcct yctgaagccg c                                               21


<210>  3391
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3391
gtagtatttc ygacatatgc a                                               21


<210>  3392
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3392
attcaaaatt rctagtgctg t                                               21


<210>  3393
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3393
atatctagaa sccatgtctt t                                               21


<210>  3394
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3394
ccaaccttca mctattttac a                                               21


<210>  3395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3395
atatgaaagg rtatatgtat t                                               21


<210>  3396
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3396
caataaacct ygtatagtgt c                                               21


<210>  3397
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3397
tttccaaatt rctgtatgca c                                               21


<210>  3398
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3398
agccattaac ycctagaaaa t                                               21


<210>  3399
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3399
agccattaac wgaagcaaga g                                               21


<210>  3400
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3400
aaaagtttat mtggaggcca g                                               21


<210>  3401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3401
gaaatggaag ygtccaataa a                                               21


<210>  3402
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3402
tgtttccaac rctcaacata a                                               21


<210>  3403
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3403
tgctggcatg ygctcaagct t                                               21


<210>  3404
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3404
taatgcatca yagtaaagga g                                               21


<210>  3405
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3405
ttcctctccc rtaacgcttt c                                               21


<210>  3406
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3406
gcaggccata yggtttccgg c                                               21


<210>  3407
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3407
caaatcatga scttagatga a                                               21


<210>  3408
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3408
atatgtactt kttattcctt t                                               21


<210>  3409
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3409
tctaaataaa yaggagccag a                                               21


<210>  3410
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3410
tcaaaccagt rattactcaa t                                               21


<210>  3411
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3411
cacaaggtaa wtttctacat a                                               21


<210>  3412
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3412
ggatactaga kagaatatgg a                                               21


<210>  3413
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3413
atattttgga wcagtgccta t                                               21


<210>  3414
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3414
aaatttctgc matctctgga g                                               21


<210>  3415
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3415
tcctatgact rgagttgtcc c                                               21


<210>  3416
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3416
tgctcttctg rtcacactgc a                                               21


<210>  3417
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3417
taatgaccct rcacaaactt a                                               21


<210>  3418
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3418
tataaattga rcttctccct g                                               21


<210>  3419
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3419
tatataagta ytgagctcta g                                               21


<210>  3420
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3420
ggggctacac yctcaacaat t                                               21


<210>  3421
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3421
tggacttaca ycttttttct t                                               21


<210>  3422
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3422
tgtcttccaa yaaactagct t                                               21


<210>  3423
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3423
cttaactaac rtaatctaat t                                               21


<210>  3424
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3424
agtggtaaca rtcacagatt c                                               21


<210>  3425
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3425
tatccaaaaa mcatcagtat a                                               21


<210>  3426
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3426
gctatcccca raataataat a                                               21


<210>  3427
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3427
tctgaaagac mgctttgcca g                                               21


<210>  3428
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3428
cccatgatat mttattgtca a                                               21


<210>  3429
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3429
tcctttctaa rtcctgtttc t                                               21


<210>  3430
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3430
attaagaagg rgctcagtta c                                               21


<210>  3431
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3431
tttatgaaag yagtatgctg t                                               21


<210>  3432
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3432
aatttattcc rcaaagctgt a                                               21


<210>  3433
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3433
cagtttacat kggaacctgt c                                               21


<210>  3434
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3434
ggttaattat ycccatttgt t                                               21


<210>  3435
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3435
ttgagcttga maatgattct t                                               21


<210>  3436
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3436
tctctgaaaa yctgctagtc a                                               21


<210>  3437
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3437
atatctaaga sagccccctt c                                               21


<210>  3438
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3438
atttctgtaa yttccaaaag a                                               21


<210>  3439
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3439
tgcacgaaaa rtaaatttca a                                               21


<210>  3440
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3440
gttttgcaac rattctccac t                                               21


<210>  3441
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3441
tcacatgtca saaaatatgg a                                               21


<210>  3442
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3442
tattttgtaa matgatgaag g                                               21


<210>  3443
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3443
tctcctttca ragactttcc c                                               21


<210>  3444
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3444
agctgttaaa kttaagtcac c                                               21


<210>  3445
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3445
agagacagaa ygctggagaa a                                               21


<210>  3446
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3446
attttcatca yttaagccag a                                               21


<210>  3447
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3447
gcttaacagc rtctggaact c                                               21


<210>  3448
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3448
tgagccatag ygctctatcc c                                               21


<210>  3449
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3449
cgcctggctc rgagggtctc a                                               21


<210>  3450
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3450
tatcacagga yagaggctat t                                               21


<210>  3451
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3451
tctataaaaa ycctgaaaga c                                               21


<210>  3452
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3452
acgctgaaat wggctatcag a                                               21


<210>  3453
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3453
gtcagtagta satgtcagtc c                                               21


<210>  3454
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3454
acatgcagtt raagaaacag t                                               21


<210>  3455
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3455
ttttgttttc raagacttta t                                               21


<210>  3456
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3456
gttttaaata kaataagcac t                                               21


<210>  3457
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3457
gaattagcat yaagattttt a                                               21


<210>  3458
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3458
aaaatggcca raaaaatcta t                                               21


<210>  3459
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3459
tcacttcaac ygttaaggac c                                               21


<210>  3460
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3460
gtttaacagt katgacaaat t                                               21


<210>  3461
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3461
attggaggaa ytgacaaagg t                                               21


<210>  3462
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3462
gaaaaaaatg ycttttaata a                                               21


<210>  3463
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3463
gaaatgacca yaggccaaga c                                               21


<210>  3464
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3464
tttaaataag ycctaaactc t                                               21


<210>  3465
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3465
tggccctagc rttcaaatag t                                               21


<210>  3466
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3466
ctgtctaccc rtgggaattt c                                               21


<210>  3467
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3467
acttaaaaac sctcctcaaa g                                               21


<210>  3468
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3468
atgcctacct yagcttcact a                                               21


<210>  3469
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3469
gaaataactt yttgtaggta a                                               21


<210>  3470
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3470
tttcgcccaa ygtgaattaa a                                               21


<210>  3471
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3471
agaatgcttc raacagaaga a                                               21


<210>  3472
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3472
cagaggtgca rtatctctga a                                               21


<210>  3473
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3473
ctattcctca yttagacaat t                                               21


<210>  3474
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3474
attctgtatg ytgaatgtat g                                               21


<210>  3475
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3475
gaatattttt staagttcaa g                                               21


<210>  3476
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3476
aaatccttgt yacatatatt t                                               21


<210>  3477
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3477
tgggtaatta matacagtag t                                               21


<210>  3478
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3478
tttagcatct rtaaatctga g                                               21


<210>  3479
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3479
tctgacttga rccactggat c                                               21


<210>  3480
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3480
aagtatgaag kttttttgca t                                               21


<210>  3481
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3481
caatgatttg rtgtcatata g                                               21


<210>  3482
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3482
tgttcgagga raggcagaag t                                               21


<210>  3483
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3483
agtctaacta rtcagagtat a                                               21


<210>  3484
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3484
gtaagttatt yggaaaggga g                                               21


<210>  3485
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3485
acatatatct rttcattgga g                                               21


<210>  3486
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3486
caaatcaata yggaaaagaa t                                               21


<210>  3487
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3487
aaattccact rttgaaactt t                                               21


<210>  3488
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3488
agttacacat raaattgccc t                                               21


<210>  3489
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3489
aaatatgtta ygcattgaat t                                               21


<210>  3490
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3490
tctgaatcac rtatgctttc t                                               21


<210>  3491
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3491
tagttatctc ygaacttact g                                               21


<210>  3492
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3492
tcatcatctg sactagcctg a                                               21


<210>  3493
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3493
ttaagtggct saggaacaca g                                               21


<210>  3494
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3494
ctgggctgga scaaggttcg c                                               21


<210>  3495
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3495
tcttgatacg rtaaattatt t                                               21


<210>  3496
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3496
caaacagatt kataaaggca g                                               21


<210>  3497
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3497
ccctgtgcaa ygtggagagc a                                               21


<210>  3498
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3498
acagagcttt mtcatcacct a                                               21


<210>  3499
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3499
ctcccaggtg ygccccagga g                                               21


<210>  3500
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3500
gacagtccag rtgaataatt t                                               21


<210>  3501
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3501
gtagcttacc ygcttgcccc g                                               21


<210>  3502
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3502
gacccaatat rgatgaagcc a                                               21


<210>  3503
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3503
aaatgtccca yaaaatagct c                                               21


<210>  3504
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3504
attgaagaag ygtcatttaa a                                               21


<210>  3505
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3505
cacccggagc saaagtagaa a                                               21


<210>  3506
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3506
agtgtaaaga ytgatcaagg c                                               21


<210>  3507
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3507
tttggatata wttagattag t                                               21


<210>  3508
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3508
ccagagggct staatatggc t                                               21


<210>  3509
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3509
ttgattaata scagaataaa c                                               21


<210>  3510
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3510
tacaaaataa rcctccttca a                                               21


<210>  3511
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3511
ggatgcctga kgtgaaaata t                                               21


<210>  3512
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3512
gagtgttaac wtccttactg c                                               21


<210>  3513
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3513
tatgtttagg yatattcctt g                                               21


<210>  3514
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3514
acaagtagta ragagaggaa c                                               21


<210>  3515
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3515
tttaagaact rgtccaaact a                                               21


<210>  3516
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3516
actctttgtt ytgccctgat t                                               21


<210>  3517
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3517
tgccctaata yatgaagttt t                                               21


<210>  3518
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3518
ttctctcaca kaacactgaa g                                               21


<210>  3519
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3519
tcattcacca ytttattttg c                                               21


<210>  3520
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3520
aaaaaaacct rcaaattaag t                                               21


<210>  3521
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3521
aatgatcgct staaacattc t                                               21


<210>  3522
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3522
attgacttac rtgaaatctg g                                               21


<210>  3523
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3523
caattctttt yggaggtaac a                                               21


<210>  3524
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3524
actgaaaatg ytacgtcaga g                                               21


<210>  3525
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3525
cacgttatac raacttggca c                                               21


<210>  3526
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3526
ttctgcaatt ktaattcctc t                                               21


<210>  3527
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3527
gttataatct rtggcaactg a                                               21


<210>  3528
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3528
ttaaatctta ygtttccatt t                                               21


<210>  3529
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3529
gggtctactg yacattatta c                                               21


<210>  3530
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3530
gtttgacagg ycctccctac c                                               21


<210>  3531
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3531
tctatttaca ractacatat t                                               21


<210>  3532
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3532
taatacataa rtctctcata a                                               21


<210>  3533
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3533
caaaaattca ygtccaattt c                                               21


<210>  3534
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3534
tatatgaaag ktgaaggctg t                                               21


<210>  3535
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3535
tcccaggatg rccccaatag a                                               21


<210>  3536
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3536
ttaaacctgt ratttcatcg g                                               21


<210>  3537
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3537
aaagtattct rcctacaatt t                                               21


<210>  3538
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3538
ccatagagag yggttctttt a                                               21


<210>  3539
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3539
tttccatggc rcgagtctcc a                                               21


<210>  3540
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3540
aggcattttt scctttaaca c                                               21


<210>  3541
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3541
ggagtaaggc wgtcacctgt c                                               21


<210>  3542
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3542
tttcaaattt sgagaaagat a                                               21


<210>  3543
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3543
ttgcgagtgc raaaacatct g                                               21


<210>  3544
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3544
aaaaagccta mataccaatt a                                               21


<210>  3545
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3545
ttctaagatg ytgctcagtg g                                               21


<210>  3546
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3546
acttaaatca yagaagctgc t                                               21


<210>  3547
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3547
tctgcagcca yctgaatcaa a                                               21


<210>  3548
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3548
aaatccctac ytactcatgt t                                               21


<210>  3549
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3549
ctcaagacca saaagttttt g                                               21


<210>  3550
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3550
ctttggcacc rgttacaaag g                                               21


<210>  3551
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3551
attaactaac rtaagtaaaa t                                               21


<210>  3552
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3552
cctctatagg mctccattaa t                                               21


<210>  3553
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3553
actccctttg yctggaatga c                                               21


<210>  3554
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3554
gctaggttaa mtggtcttag t                                               21


<210>  3555
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3555
ccattaaaaa ycttctggct c                                               21


<210>  3556
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3556
tggctactaa ygtgcaccat a                                               21


<210>  3557
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3557
ctccttcctt yatcctttta a                                               21


<210>  3558
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3558
agttaacaaa rgaacaaaag t                                               21


<210>  3559
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3559
caattcaccc yttggttagt t                                               21


<210>  3560
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3560
cataactgag rctatccagc a                                               21


<210>  3561
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3561
ggagtaaaga yattatacaa a                                               21


<210>  3562
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3562
ctgtatcttg rtgaatttca t                                               21


<210>  3563
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3563
ccagatattt ycattttgct g                                               21


<210>  3564
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3564
tctgtgcagt mccagtgcca g                                               21


<210>  3565
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3565
actaatttct stttctctca a                                               21


<210>  3566
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3566
gagaaatcag raaaattaat t                                               21


<210>  3567
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3567
ttcctcccaa rttagcaggc t                                               21


<210>  3568
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3568
ctctctcctc stgcactgct a                                               21


<210>  3569
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3569
catttctgaa rttctgtggt a                                               21


<210>  3570
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3570
ttccatgaac ytcaaggtct a                                               21


<210>  3571
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3571
caacatggga scccacaaag a                                               21


<210>  3572
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3572
tttattcctt ygtaaattct g                                               21


<210>  3573
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3573
ttagagacaa yaggcatcaa a                                               21


<210>  3574
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3574
gtagcaaaag kgataagtaa t                                               21


<210>  3575
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3575
taggactttc ytcaccaaat a                                               21


<210>  3576
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3576
ctaaacattt yctagcataa t                                               21


<210>  3577
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3577
taagtagctg rtagaaaagt c                                               21


<210>  3578
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3578
accaggtaca ygaagaggac t                                               21


<210>  3579
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3579
aagtcctatt kgtctatttt t                                               21


<210>  3580
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3580
acgtttcaca rtctagccca c                                               21


<210>  3581
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3581
aaagtaagtg wtggcattcc t                                               21


<210>  3582
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3582
gctgcatcta sgttttgcaa a                                               21


<210>  3583
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3583
agtccacagg ygctaccctg g                                               21


<210>  3584
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3584
gcctactccc raaagggctc a                                               21


<210>  3585
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3585
gagccttctt yagcacgtgc t                                               21


<210>  3586
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3586
aaaatattgg satacaaaat a                                               21


<210>  3587
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3587
agtcatataa yacatactct a                                               21


<210>  3588
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3588
tccacctatc rggcattatt g                                               21


<210>  3589
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3589
tgacaaaact rtaaggtagg t                                               21


<210>  3590
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3590
tagagtttag rtaagtttcc c                                               21


<210>  3591
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3591
gccatcatac rccatcagat t                                               21


<210>  3592
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3592
tctcgtctcc rttggggtcg t                                               21


<210>  3593
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3593
ttcagtgccc mtagtacaaa g                                               21


<210>  3594
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3594
atagttgaag kctttggaag a                                               21


<210>  3595
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3595
tcaggcttgg rtataccata a                                               21


<210>  3596
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3596
ggctgcttta mttactaaat g                                               21


<210>  3597
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3597
tctaatagtg raaatatgac t                                               21


<210>  3598
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3598
ggacacaaat rtatcaccct c                                               21


<210>  3599
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3599
aactctccac yaagctagac c                                               21


<210>  3600
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3600
attgtttatg ktatttatgc a                                               21


<210>  3601
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3601
agtattttct ycaatgctaa g                                               21


<210>  3602
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3602
gagcttgtcc raagtaattt t                                               21


<210>  3603
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3603
atattcttaa ytttacctgc c                                               21


<210>  3604
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3604
tagcagttag ytgaaacaac a                                               21


<210>  3605
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3605
gcccactcta yaaatgagga c                                               21


<210>  3606
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3606
caggagattc rtggcaggcg g                                               21


<210>  3607
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3607
tgaggtggct ygccccaagg c                                               21


<210>  3608
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3608
ttgcagatgg rgcctgagat g                                               21


<210>  3609
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3609
agttagacct yacatcctgt t                                               21


<210>  3610
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3610
ttcctttcca mtctctaatc c                                               21


<210>  3611
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3611
attttgtaag ytgaattcca t                                               21


<210>  3612
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3612
tcaaatgaga yggtggttgt g                                               21


<210>  3613
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3613
ggttgattgg ygaccggaag c                                               21


<210>  3614
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3614
cccaagacag rcactcagtt g                                               21


<210>  3615
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3615
tgaggcaatg stcacctgtc t                                               21


<210>  3616
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3616
ttgaaacaac ytcacacacc c                                               21


<210>  3617
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3617
tgcattccaa yttccctgaa c                                               21


<210>  3618
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3618
ttcctagatt rgtattctcg c                                               21


<210>  3619
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3619
aatggaaata ygtgatgtgg a                                               21


<210>  3620
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3620
cttgaattgc ycttaaatca c                                               21


<210>  3621
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3621
acgcttccct ygagggagga c                                               21


<210>  3622
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3622
gatagaagga ytcactctta a                                               21


<210>  3623
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3623
cgaagagacc statgcaaag g                                               21


<210>  3624
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3624
ttcacaggga rgtacaagaa a                                               21


<210>  3625
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3625
tcttgaaggt ygtcactgcc c                                               21


<210>  3626
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3626
tttagagaat wtaaattttg c                                               21


<210>  3627
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3627
tgtcaggcag yagaaggaag a                                               21


<210>  3628
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3628
taatttatac rcacaaaact a                                               21


<210>  3629
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3629
cctcaggaac yacattatgt g                                               21


<210>  3630
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3630
ctgtcctatg ytgagtaaga g                                               21


<210>  3631
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3631
gatcaagcat ygttgatgac c                                               21


<210>  3632
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3632
gatgcccaac rtggaggatc a                                               21


<210>  3633
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3633
acaaggtggc yatctatgac a                                               21


<210>  3634
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3634
gtgtaagttt rtggctaggg g                                               21


<210>  3635
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3635
tcctgtaaaa ytgattcatt a                                               21


<210>  3636
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3636
tagagttgtc ragaggattt a                                               21


<210>  3637
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3637
catatagtgg rccacactct g                                               21


<210>  3638
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3638
ataaacctgc ytgatggtaa c                                               21


<210>  3639
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3639
gttctacctc waagaccgat c                                               21


<210>  3640
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3640
ggaaccttct ycatgtagta g                                               21


<210>  3641
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3641
tcaagactca ygtttattca g                                               21


<210>  3642
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3642
agcttagcca yggtaaaata g                                               21


<210>  3643
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3643
gtggaagaga yggttttttc t                                               21


<210>  3644
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3644
gctcctctac sttcggcaca g                                               21


<210>  3645
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3645
aacgtacact stttaatgtt a                                               21


<210>  3646
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3646
tccataacct yggtaataca a                                               21


<210>  3647
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3647
tgatggagta wgtaatagga c                                               21


<210>  3648
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3648
ggttttagac stcttatcca g                                               21


<210>  3649
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3649
ataaaatcta wgtctggaag c                                               21


<210>  3650
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3650
tctggaccca rtcgttgttg g                                               21


<210>  3651
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3651
tgggtcccta ygtcaaaggc a                                               21


<210>  3652
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3652
atttcactgg ygtctttaag g                                               21


<210>  3653
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3653
aataagatac ragctttgaa t                                               21


<210>  3654
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3654
cacttgacag wctaatccac t                                               21


<210>  3655
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3655
acatgtgctt sctcaggtac t                                               21


<210>  3656
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3656
gatcaatata yacaaggcat t                                               21


<210>  3657
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3657
acacttcaaa rttagaaata g                                               21


<210>  3658
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3658
gatgtcccag rcactacaag a                                               21


<210>  3659
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3659
tcccctttag wttttcttag c                                               21


<210>  3660
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3660
tgcccctatt rctttcttgc t                                               21


<210>  3661
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3661
cctcaactta yaatgttaga a                                               21


<210>  3662
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3662
tggcttaaaa wacctcagaa g                                               21


<210>  3663
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3663
atgtactttg rgtgataata t                                               21


<210>  3664
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3664
gtaactgatt ktgtttacaa g                                               21


<210>  3665
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3665
ttataaccac mcatttaagg t                                               21


<210>  3666
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3666
ctaattcttt ytgaaacttg c                                               21


<210>  3667
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3667
agatagtcat yagcattaac a                                               21


<210>  3668
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3668
gtcacttttt waaagaagat t                                               21


<210>  3669
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3669
gttaggcatc ytccttgcag g                                               21


<210>  3670
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3670
tttgtaaact rtgttactgt c                                               21


<210>  3671
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3671
ttttgttact sttctctcct t                                               21


<210>  3672
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3672
gccatgttta rcaggtacta c                                               21


<210>  3673
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3673
tattgaaaag sctatttcta t                                               21


<210>  3674
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3674
agaacagcaa yggacaaaga g                                               21


<210>  3675
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3675
tttattagtt ygaggttgac t                                               21


<210>  3676
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3676
agcattttgc wgttagctgg c                                               21


<210>  3677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3677
gattttgaac saagctctgt a                                               21


<210>  3678
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3678
gtgcacaaaa katgtgtgtt t                                               21


<210>  3679
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3679
cctttttaga ygaagcagat c                                               21


<210>  3680
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3680
ggaacagata ycttgatctc a                                               21


<210>  3681
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3681
aaatgaggct ytgtgcattc c                                               21


<210>  3682
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3682
attaggtcaa yagggactta a                                               21


<210>  3683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3683
tgcctgcagt ytggcatgct t                                               21


<210>  3684
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3684
ggctatgcac rtcactgagg t                                               21


<210>  3685
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3685
atattacacc rggtggaaca g                                               21


<210>  3686
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3686
caacgctaaa wgacagccat c                                               21


<210>  3687
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3687
ccctgggcac rgattacagc t                                               21


<210>  3688
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3688
tggctttgca sagctactaa a                                               21


<210>  3689
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3689
cagtgaatca rtgcaaagct c                                               21


<210>  3690
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3690
tctttgacaa ygtattgtgt a                                               21


<210>  3691
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3691
aacaactaca rcagaggcat c                                               21


<210>  3692
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3692
atggcccatc rtaacgtccc c                                               21


<210>  3693
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3693
tcggtcacta yggactggct t                                               21


<210>  3694
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3694
catggatagg sctcagcttg c                                               21


<210>  3695
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3695
acttcataca rcatatagct t                                               21


<210>  3696
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3696
aggatatact rtttacattg t                                               21


<210>  3697
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3697
tgtgtataat rtcaactatt a                                               21


<210>  3698
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3698
gctccaaggt rtttctagct t                                               21


<210>  3699
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3699
gccaagtacc kagtgttggc t                                               21


<210>  3700
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3700
tatccacaga ygaccttatg t                                               21


<210>  3701
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3701
atgaagcctg raaaatgagt t                                               21


<210>  3702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3702
caaatgaaga ratggaaggt t                                               21


<210>  3703
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3703
aaccaaaata yggaattgaa t                                               21


<210>  3704
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3704
atgtccctaa kagcatctct t                                               21


<210>  3705
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3705
tctgctacta yagacctaat g                                               21


<210>  3706
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3706
atacaattca mcattatttc c                                               21


<210>  3707
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3707
gacccatata matgtggaaa g                                               21


<210>  3708
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3708
ttgtgttgtc yatctacctt c                                               21


<210>  3709
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3709
tcagaggatg ytcaagtccc t                                               21


<210>  3710
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3710
tatcctctac rtcactgtta c                                               21


<210>  3711
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3711
cagttggctg stgttaggaa t                                               21


<210>  3712
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3712
ttgcttatgg mttgcctacc a                                               21


<210>  3713
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3713
gccactctcc rctgggtcac c                                               21


<210>  3714
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3714
aatgcttttc rttgttctca c                                               21


<210>  3715
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3715
tatgtaaact ygttctggcc a                                               21


<210>  3716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3716
gttcctgtga rgggtccaga a                                               21


<210>  3717
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3717
gtatttcctg rtaattgttt g                                               21


<210>  3718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3718
ctattttgtt yatccagcta t                                               21


<210>  3719
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3719
tcttcattgc ygttcagtgc t                                               21


<210>  3720
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3720
caacacactc ractagttta c                                               21


<210>  3721
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3721
aggaattgcc rttgatttaa a                                               21


<210>  3722
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3722
tatttatggg raagtgatat t                                               21


<210>  3723
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3723
cagcttctct yggtctcact g                                               21


<210>  3724
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3724
acgactctcc yggacagcat t                                               21


<210>  3725
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3725
catgcgaaaa rtcacaggag c                                               21


<210>  3726
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3726
cttcacggcc ygctctgggg a                                               21


<210>  3727
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3727
taagaagtgg rtgactttta g                                               21


<210>  3728
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3728
gaattctgct mcgtgcatgt g                                               21


<210>  3729
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3729
acttaggctt ytaaaattta a                                               21


<210>  3730
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3730
catgttgagg yttccacaac a                                               21


<210>  3731
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3731
tcccagccca rcatcagttt t                                               21


<210>  3732
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3732
agaaaagatc sgatatctta c                                               21


<210>  3733
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3733
tagtcctgat yctgttaaga g                                               21


<210>  3734
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3734
tcataaaggg rtagcacaag g                                               21


<210>  3735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3735
ttccactgtc yttttaagaa c                                               21


<210>  3736
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3736
aaagccttgt rtaatctttg a                                               21


<210>  3737
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3737
ctggcactaa rtgggttttt t                                               21


<210>  3738
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3738
cacgtggtct wttccctgtg c                                               21


<210>  3739
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3739
gaggctattg ygaggactca c                                               21


<210>  3740
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3740
atgactccca yctgatttct t                                               21


<210>  3741
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3741
cgtcattata waactcacca a                                               21


<210>  3742
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3742
ttatcacagc rtgaaataca g                                               21


<210>  3743
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3743
agttttttca rttgccaact t                                               21


<210>  3744
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3744
aactttgcac wttcttagtg t                                               21


<210>  3745
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3745
ataacggaga yttgcctttt a                                               21


<210>  3746
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3746
cttcctcatt rgccatgtaa a                                               21


<210>  3747
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3747
acttacacga ygtacttatg t                                               21


<210>  3748
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3748
tcatttatct ycattgcaaa a                                               21


<210>  3749
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3749
acagtatgac sttctagaac a                                               21


<210>  3750
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3750
atttgtcctt rtaagtctct a                                               21


<210>  3751
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3751
agtgaattcc ygtggtagtc t                                               21


<210>  3752
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3752
gacttccaca rccttgattg t                                               21


<210>  3753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3753
cacaatccag mgtaattgtg c                                               21


<210>  3754
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3754
atgtatggcc stggtgagtg g                                               21


<210>  3755
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3755
tcattaacct kagagtcata t                                               21


<210>  3756
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3756
acttaatcca ygtgcacagt g                                               21


<210>  3757
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3757
agcagcagag rttagaaagc a                                               21


<210>  3758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3758
tttggggaga rtaagaccat t                                               21


<210>  3759
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3759
attttctttg sattgctata t                                               21


<210>  3760
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3760
tcttgagctc yctgaactgt a                                               21


<210>  3761
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3761
aaaccaagca yatacagctg g                                               21


<210>  3762
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3762
cattccttag rccaacagtc c                                               21


<210>  3763
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3763
ctacccaagc rtacagatgt t                                               21


<210>  3764
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3764
tggagatact yggtaaatgt t                                               21


<210>  3765
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3765
gagatgccta ygaaaataga g                                               21


<210>  3766
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3766
ctggaatgat rgtgagctag t                                               21


<210>  3767
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3767
tgaggtttct sttacatgtt t                                               21


<210>  3768
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3768
ttttcaaatg ygtcattcaa a                                               21


<210>  3769
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3769
atttaatgta yagtaatgca t                                               21


<210>  3770
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3770
agtcattttg ragtgattac a                                               21


<210>  3771
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3771
cagatacaaa ygtggagtta c                                               21


<210>  3772
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3772
gataattaag rtatggcttt t                                               21


<210>  3773
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3773
tctttcgaat yctagcatta a                                               21


<210>  3774
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3774
ctctaagctg rtttgaacag a                                               21


<210>  3775
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3775
tcgattacta ycctctttga a                                               21


<210>  3776
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3776
tacataatgc rtgagattgt g                                               21


<210>  3777
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3777
tttctgtcca rtctgtggct g                                               21


<210>  3778
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3778
atgccaggga rtacaatatt c                                               21


<210>  3779
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3779
gattaaaagt ytatggtact a                                               21


<210>  3780
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3780
ctgactaata yggctaccca g                                               21


<210>  3781
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3781
ttctagaata ygtaaatgag a                                               21


<210>  3782
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3782
tccagtttca rtattatgca a                                               21


<210>  3783
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3783
catacattaa mctacaaata g                                               21


<210>  3784
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3784
tgtataaaaa rtaataatag c                                               21


<210>  3785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3785
agagggcacc rcctgcacct g                                               21


<210>  3786
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3786
ggtggcaaca kcagggagga a                                               21


<210>  3787
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3787
acccaaggaa mtgctataat c                                               21


<210>  3788
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3788
ttctagattg ycttttttca c                                               21


<210>  3789
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3789
tttaaagatg kaacaggata t                                               21


<210>  3790
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3790
cctgacccaa ygagtggaag t                                               21


<210>  3791
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3791
attttaaaac katgtgattc a                                               21


<210>  3792
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3792
ctgtaacagc yctcagaata t                                               21


<210>  3793
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3793
taatgctttc mtggtagcag g                                               21


<210>  3794
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3794
ttgaaaacag rtagtcagat a                                               21


<210>  3795
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3795
actgtgtccc yacacatttc a                                               21


<210>  3796
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3796
aagcggggtg ygatgtttgg a                                               21


<210>  3797
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3797
atcgaaaatc ygttgtaagg a                                               21


<210>  3798
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3798
tccttctgga yggactaggg g                                               21


<210>  3799
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3799
aaaggaggtc ytattatctc c                                               21


<210>  3800
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3800
tgtttttaag rctcttgata c                                               21


<210>  3801
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3801
ggcccctctg yggctgggcc t                                               21


<210>  3802
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3802
ctggggaatg rgatgcaagt g                                               21


<210>  3803
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3803
cctcctataa matccactcc t                                               21


<210>  3804
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3804
ccaatgcaca stgcccatcc a                                               21


<210>  3805
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3805
gtaccaacta yctgcaaggc a                                               21


<210>  3806
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3806
gggttcgggc mcccactttg a                                               21


<210>  3807
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3807
gagagtggcc rgtcctagat g                                               21


<210>  3808
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3808
aagcaaagga yggtgtctgt t                                               21


<210>  3809
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3809
cagccacagc rtatgaggaa g                                               21


<210>  3810
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3810
aacactcatg rtgtgccaag t                                               21


<210>  3811
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3811
gatgcggcac sgcacttcga t                                               21


<210>  3812
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3812
gtgcctacct ygctcaccct t                                               21


<210>  3813
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3813
tttaactgga ygtgaatgag t                                               21


<210>  3814
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3814
tgaggtccag rgctccaatc t                                               21


<210>  3815
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3815
ctgggagatc ytccattcag c                                               21


<210>  3816
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3816
gtatctggta ktgggtgatc t                                               21


<210>  3817
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3817
aaaaagttat rcactggatt a                                               21


<210>  3818
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3818
cccactacaa sttctgctac c                                               21


<210>  3819
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3819
tctttctttt mcatttttag t                                               21


<210>  3820
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3820
tgtggtcctc rtctcctgtg g                                               21


<210>  3821
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3821
agaagccaat wcaagtctcc a                                               21


<210>  3822
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3822
tctaagagcc rtatgacaaa g                                               21


<210>  3823
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3823
gaagtgaggg ygcccagtgc t                                               21


<210>  3824
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3824
catctatagg yattcctgtt c                                               21


<210>  3825
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3825
acattagcgc ytccgccccc t                                               21


<210>  3826
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3826
tctctggtaa rttagaaacc g                                               21


<210>  3827
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3827
tcctcaagaa mgacttgcat t                                               21


<210>  3828
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3828
cagttgtctc ratgcctagt a                                               21


<210>  3829
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3829
ttcaagtgtt wgtttggaat a                                               21


<210>  3830
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3830
agaaacctag yggtagcaag t                                               21


<210>  3831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3831
ctggtcctgc rtttggctct g                                               21


<210>  3832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3832
gcagttggat sacttgattt t                                               21


<210>  3833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3833
aaataagatt yttttgaata g                                               21


<210>  3834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3834
tgacaaccac rtacagctca a                                               21


<210>  3835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3835
gatttttgga kttaaatggc t                                               21


<210>  3836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3836
gtaggtacca ycctaaggca c                                               21


<210>  3837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3837
tgaactttgg rtggagagag c                                               21


<210>  3838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3838
acaacagcaa yatttttaaa c                                               21


<210>  3839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3839
aatcctccca ygagaatttt a                                               21


<210>  3840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3840
agttttgctt ytggcagtta a                                               21


<210>  3841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3841
tcagaaattt rgattaacaa g                                               21


<210>  3842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3842
ttatgagtaa yatgaggcat t                                               21


<210>  3843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3843
tcagcaccaa kaataggcct a                                               21


<210>  3844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3844
gaggaaaaaa yacaatgtat c                                               21


<210>  3845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3845
taattccagc ytcaatgtat c                                               21


<210>  3846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3846
tactcagtga waaaagactg a                                               21


<210>  3847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3847
ccagtattag wttttatttt t                                               21


<210>  3848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3848
acacaataaa rcagataata g                                               21


<210>  3849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3849
caaagagatc rtctcagctc t                                               21


<210>  3850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3850
cagagcaaag rattgtacat c                                               21


<210>  3851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3851
tgaaaatgta raataacaat g                                               21


<210>  3852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3852
ttttctcatg ygtaagttgg t                                               21


<210>  3853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3853
agccttctct ygtgacagtg t                                               21


<210>  3854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3854
cattttctca rctctctagc t                                               21


<210>  3855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3855
tgttaggtta yagagacaaa t                                               21


<210>  3856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3856
ctcaaagccc rcattcacgg a                                               21


<210>  3857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3857
tgaacccact kttttcagac t                                               21


<210>  3858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3858
cagatatttt ycctcttccc c                                               21


<210>  3859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3859
ggctaataga mcattggtta a                                               21


<210>  3860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3860
ttccacacac rtgggatgaa c                                               21


<210>  3861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3861
agaacagata ytgaaaaagc t                                               21


<210>  3862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3862
agactgctat ytgttttggt g                                               21


<210>  3863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3863
gggagaacaa ytttaaaaat t                                               21


<210>  3864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3864
ccccatagcc rggtgtcatt c                                               21


<210>  3865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3865
tccttggaaa yaatgaaata c                                               21


<210>  3866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3866
tgttgcattt kgttgtcttt t                                               21


<210>  3867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3867
cttcttttct rttcaccaca c                                               21


<210>  3868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3868
tgccctgtgc mtttgaagtc a                                               21


<210>  3869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3869
gactctatgc rtgtcaagca t                                               21


<210>  3870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3870
caaactcaac wttttagtta g                                               21


<210>  3871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3871
tctttcctga yggtgggctg g                                               21


<210>  3872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3872
tgatcccaat ytccatttca t                                               21


<210>  3873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3873
ctctcctatt ygcatccatg t                                               21


<210>  3874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3874
gctctctaag ytttctaaat a                                               21


<210>  3875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3875
atctatgcag yatacactaa c                                               21


<210>  3876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3876
agagacatta ytttgggtgc c                                               21


<210>  3877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3877
agtttaacac yaatgatgga t                                               21


<210>  3878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3878
aactcttcta yatcttcaac t                                               21


<210>  3879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3879
ctcagttacg statatatta g                                               21


<210>  3880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3880
atagagaagc yagagaaatt c                                               21


<210>  3881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3881
agaaaaaaaa raaagggcca t                                               21


<210>  3882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3882
attcagcact ytgaatttca g                                               21


<210>  3883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3883
attaggaaac ktgaagacat t                                               21


<210>  3884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3884
gtaaaacaca ytctgaagta c                                               21


<210>  3885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3885
aaggtaaaat mgtcacaggt g                                               21


<210>  3886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3886
accatcatca ygtctaaaac c                                               21


<210>  3887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3887
tgcataaagt ytgaaaaaag t                                               21


<210>  3888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3888
atatctatca ytaacagaaa c                                               21


<210>  3889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3889
acattagtgt ygttttcaca g                                               21


<210>  3890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3890
gttcacttac rgatgtccat a                                               21


<210>  3891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3891
cctcaccact wtggctactc c                                               21


<210>  3892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3892
ataataactg maagtctgac a                                               21


<210>  3893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3893
tctgaactcc yttctttacc t                                               21


<210>  3894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3894
ctgccacatg rttacaagga c                                               21


<210>  3895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3895
acagctctgc scactgggag a                                               21


<210>  3896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3896
gctgttttgg wcatccctag t                                               21


<210>  3897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3897
ttaaagataa kaattgctgc a                                               21


<210>  3898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3898
ctttttgaaa yggctttcaa a                                               21


<210>  3899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3899
aaaacacacc rgttgactat t                                               21


<210>  3900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3900
gaacttgagt rttccaagga g                                               21


<210>  3901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3901
ttgcccatag ygtttggata t                                               21


<210>  3902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3902
ataaaataaa rgtagacttc t                                               21


<210>  3903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3903
gattaatact wttaaaaggc c                                               21


<210>  3904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3904
tatatatgtt kaagagatga a                                               21


<210>  3905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3905
tccaaaccac rttgctgctg c                                               21


<210>  3906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3906
atttgtagga yatttgcatt t                                               21


<210>  3907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3907
gaggcgcctg mccaagtgat g                                               21


<210>  3908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3908
ccctgggctt kcaggctgat g                                               21


<210>  3909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3909
aggaccaata yacatgctca g                                               21


<210>  3910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3910
tcaacttgag rcaaagcagg a                                               21


<210>  3911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3911
acaaaattgc rttccttccc t                                               21


<210>  3912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3912
ttccagcttt wgatcttcca c                                               21


<210>  3913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3913
tttggaaata rgaaggtgat t                                               21


<210>  3914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3914
gtaccaaatg ytccttttta t                                               21


<210>  3915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3915
ccaattgcaa mtccaagtta g                                               21


<210>  3916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3916
tttctgatta yggaaaatac c                                               21


<210>  3917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3917
tatccaggga ygcttcattc t                                               21


<210>  3918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3918
acccacaatg yaaggaagac a                                               21


<210>  3919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3919
attagatcca ycaagtaact c                                               21


<210>  3920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3920
cttcattctc yaactacagc c                                               21


<210>  3921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3921
cttccatcac ytacagatcc a                                               21


<210>  3922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3922
ctccaaaata yatccatctt t                                               21


<210>  3923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3923
gcttttactc rtgctgtttc t                                               21


<210>  3924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3924
ctaaaaatag yaccatatct c                                               21


<210>  3925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3925
tcctaaacct rctatttcag a                                               21


<210>  3926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3926
gtaaaaaaat rtcacaaatg c                                               21


<210>  3927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3927
agaactatca rgtcttcctg a                                               21


<210>  3928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3928
tccacaacat kaccctgtca a                                               21


<210>  3929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3929
atgagagcta ytggctcaaa c                                               21


<210>  3930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3930
tgtttccaag wagtacattg t                                               21


<210>  3931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3931
tggatacgtc ktgaaatact a                                               21


<210>  3932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3932
gttatggttc raggccaggg t                                               21


<210>  3933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3933
gttatctagc rgaaaacagc c                                               21


<210>  3934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3934
taaagagccc rctaatttag a                                               21


<210>  3935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3935
ttattgtctt rttagctgaa g                                               21


<210>  3936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3936
aaagctaatg stgtaaaaat a                                               21


<210>  3937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3937
ttcccagggg ktacgggttc c                                               21


<210>  3938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3938
gggcttccaa yttaatattc a                                               21


<210>  3939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3939
gaatcctttt wagattaatt g                                               21


<210>  3940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3940
ttgagaagaa yctaactgtt c                                               21


<210>  3941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3941
catcccttct staagaacac t                                               21


<210>  3942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3942
cctgtctttt rgcaactttg t                                               21


<210>  3943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3943
agaaactcct yggggataga g                                               21


<210>  3944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3944
acataggttc rgagagtcat c                                               21


<210>  3945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3945
aataagaaaa scaagctgca g                                               21


<210>  3946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3946
atgtttagac kagactggaa g                                               21


<210>  3947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3947
ccatctcctc kgctagattt g                                               21


<210>  3948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3948
aattcgttac rtattatttt c                                               21


<210>  3949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3949
taatttagtg rcaactacct a                                               21


<210>  3950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3950
gaggtttgtc ktagtcccat t                                               21


<210>  3951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3951
tcttactaag ytaaatttca t                                               21


<210>  3952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3952
tttcttaaca sattttaaac a                                               21


<210>  3953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3953
tgagcaagtg yattttcaac c                                               21


<210>  3954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3954
agtcctgatt ytctccttta a                                               21


<210>  3955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3955
tatccctttg wtgcactggt c                                               21


<210>  3956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3956
ttgcgttaac sttgttttag g                                               21


<210>  3957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3957
tctaccactg rtgacaggtt g                                               21


<210>  3958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3958
gtattgactt ytgtgttttc a                                               21


<210>  3959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3959
ggtgcggatc rtatgctata a                                               21


<210>  3960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3960
caatgaagtc ragagaaaac t                                               21


<210>  3961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3961
ggaaagcacg ygttgattgc c                                               21


<210>  3962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3962
gattctaaat rgctgtatta t                                               21


<210>  3963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3963
gcattagcca sgtctaggga g                                               21


<210>  3964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3964
atattgtttt ygttcagaat a                                               21


<210>  3965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3965
atgaaagtga yggatggtac t                                               21


<210>  3966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3966
gacttcagaa katctttaac t                                               21


<210>  3967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3967
ggagcctgac ygttcacact a                                               21


<210>  3968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3968
tgtgataatt kgactatttc a                                               21


<210>  3969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3969
tcaaatactt ytatccatgt c                                               21


<210>  3970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3970
gcttggatac ygttcccatt c                                               21


<210>  3971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3971
ctcatttgct rttcaaggaa c                                               21


<210>  3972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3972
tcaaaaatga matacccgtg a                                               21


<210>  3973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3973
agctctaaaa rtttacccaa g                                               21


<210>  3974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3974
agactaatct ygtatctcta a                                               21


<210>  3975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3975
ggtgcttttg ycatttgcag a                                               21


<210>  3976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3976
ctaccaaatt scacctttcc c                                               21


<210>  3977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3977
ttggacaata raagcaattt a                                               21


<210>  3978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3978
ctgtttcacc rtttctcaga a                                               21


<210>  3979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3979
ccaagattgc ktcaatgttc t                                               21


<210>  3980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3980
tctagccttc ygtcaaagca t                                               21


<210>  3981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3981
gctctgccaa yttcaggcag t                                               21


<210>  3982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3982
atgactaatc raattattgc a                                               21


<210>  3983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3983
aatacactat ygaattaaaa a                                               21


<210>  3984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3984
tagtcttaga yttgcagcag a                                               21


<210>  3985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3985
tgactgggaa yggttttggg t                                               21


<210>  3986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3986
gaattttttc rggaaagtct t                                               21


<210>  3987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3987
tgctaccttt rtccagtaat t                                               21


<210>  3988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3988
ccattcccaa kacttggatt a                                               21


<210>  3989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3989
ggttcttttc raactcctag g                                               21


<210>  3990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3990
ggcaatgtaa rtatgacatt t                                               21


<210>  3991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3991
atcttccttc ycttttgcta g                                               21


<210>  3992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3992
gtaggtagat yctaaatgct t                                               21


<210>  3993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3993
agcatgaaca rcaggacaaa a                                               21


<210>  3994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3994
ttgacccacc rcgcgcgacc c                                               21


<210>  3995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3995
gttacaaatt kcttgagatg a                                               21


<210>  3996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3996
tagaatttca macagtaaag a                                               21


<210>  3997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3997
atatgtagga rtgccctttg g                                               21


<210>  3998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3998
agagtgcaga rgttcacatg g                                               21


<210>  3999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3999
tccaccagaa rggtacattg g                                               21


<210>  4000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4000
ttgaaatgaa ktcttgatct a                                               21


<210>  4001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4001
tatatccttg yctgcatttg g                                               21


<210>  4002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4002
aggggtcatg yaatcgttta t                                               21


<210>  4003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4003
gtttacatca ratgtgtcta g                                               21


<210>  4004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4004
catgtgtcaa raaaaagtta t                                               21


<210>  4005
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4005
gcatatctgg yttaaaagca a                                               21


<210>  4006
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4006
catgttttgg mtatttacct a                                               21


<210>  4007
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4007
tcctttggca scaagagtaa t                                               21


<210>  4008
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4008
taaccactca rtaatctgga c                                               21


<210>  4009
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4009
taaagatcag ygtggactgc a                                               21


<210>  4010
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4010
ggctggagag stttcagagg t                                               21


<210>  4011
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4011
ttttattcac ygctaccacg g                                               21


<210>  4012
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4012
attctggcag stggcacttc a                                               21


<210>  4013
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4013
ttctaccaca ygtttaaata t                                               21


<210>  4014
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4014
ttctgtatac sttatctgct t                                               21


<210>  4015
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4015
ggtatagaca yagattgcca g                                               21


<210>  4016
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4016
gtgattgcta wctttgtttt c                                               21


<210>  4017
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4017
acaaacactt wttgagcact g                                               21


<210>  4018
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4018
caccggttct yttaaccgtt c                                               21


<210>  4019
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4019
tactgagttc rtgagattct t                                               21


<210>  4020
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4020
atatatgtca mtcaaatgtg t                                               21


<210>  4021
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4021
tacagtgata yatggttgat a                                               21


<210>  4022
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4022
tatctttcac wgcagcaagt a                                               21


<210>  4023
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4023
ggcttaagaa yacccggcat g                                               21


<210>  4024
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4024
aaggagagta sagttacaaa g                                               21


<210>  4025
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4025
agtgatgata mcatgttctg t                                               21


<210>  4026
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4026
ttgacgagca mgttttttgg t                                               21


<210>  4027
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4027
taagtcttta ygtgtgaaaa c                                               21


<210>  4028
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4028
aaggagaacg rcagtttgtg t                                               21


<210>  4029
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4029
ccaaatattt kaaaaactaa a                                               21


<210>  4030
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4030
ctgctttgca rttaggagtg c                                               21


<210>  4031
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4031
tgtttttact raaaattaga g                                               21


<210>  4032
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4032
aggaatattc yagggactgc a                                               21


<210>  4033
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4033
aattatcact scaagtctgc c                                               21


<210>  4034
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4034
atctctaaaa wctcagccag a                                               21


<210>  4035
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4035
taacataacc rttgtgaaca g                                               21


<210>  4036
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4036
gggaaaacca ygataagcct c                                               21


<210>  4037
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4037
agagaaggta yggtgcaggg a                                               21


<210>  4038
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4038
tattgcaaat rgacactatg t                                               21


<210>  4039
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4039
gtttttgtaa ytgtctctgt t                                               21


<210>  4040
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4040
cctcactttc ytaggcatta t                                               21


<210>  4041
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4041
tgcagtgtac rttacttgaa t                                               21


<210>  4042
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4042
ggtgtatggt yggaaagcca c                                               21


<210>  4043
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4043
taaggattcc kacactaaat g                                               21


<210>  4044
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4044
ggtgctcgcc yaaagcctga c                                               21


<210>  4045
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4045
aagctcttca rgtggccagt t                                               21


<210>  4046
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4046
gagatttaca ytggggtggg c                                               21


<210>  4047
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4047
atctttggaa ytgaaaacct c                                               21


<210>  4048
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4048
aatataataa ygacattcag t                                               21


<210>  4049
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4049
tctggaggaa ktgcagttta g                                               21


<210>  4050
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4050
aaatgtggac satggggaag c                                               21


<210>  4051
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4051
tgggttattt stgcctagtg t                                               21


<210>  4052
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4052
aatgagtggc yggtgaacag c                                               21


<210>  4053
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4053
ctttaggatg ytttaaaggg a                                               21


<210>  4054
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4054
tcatttagca wacacacatt t                                               21


<210>  4055
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4055
tagccatgca rtataaatgc t                                               21


<210>  4056
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4056
ctgtcaccta scccatgccg t                                               21


<210>  4057
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4057
ggcaagagag ytgactagaa g                                               21


<210>  4058
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4058
tctaattgcc rcaggaattc a                                               21


<210>  4059
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4059
acaatatcct ytgggagaac g                                               21


<210>  4060
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4060
acacagcttg maacttttat g                                               21


<210>  4061
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4061
tcgtttccag rttaaaaaaa g                                               21


<210>  4062
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4062
gcatggatta rctatacatt t                                               21


<210>  4063
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4063
actattaatc raatcacatt a                                               21


<210>  4064
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4064
actataaacc rattgctatg g                                               21


<210>  4065
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4065
atgctcgtac mgaaggctat a                                               21


<210>  4066
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4066
tacttcctga ycctataggt t                                               21


<210>  4067
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4067
caaatgtgtc rtgctattcc a                                               21


<210>  4068
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4068
tataagctca ratttggaaa c                                               21


<210>  4069
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4069
gcattatgac watatcacta c                                               21


<210>  4070
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4070
agagagacac magatactat c                                               21


<210>  4071
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4071
tctaaagttg rcagaagaat c                                               21


<210>  4072
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4072
tctgcatcct sagttcagtg c                                               21


<210>  4073
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4073
gattcagttc rtctcctttt t                                               21


<210>  4074
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4074
ggcacataca rctactaacc a                                               21


<210>  4075
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4075
caaatagcac rtaaactaga a                                               21


<210>  4076
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4076
cattcatttc yaaaacattg c                                               21


<210>  4077
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4077
attatgtgca kttactatca g                                               21


<210>  4078
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4078
gttaaactct rttcccttga t                                               21


<210>  4079
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4079
gtcatcttat stagccttca a                                               21


<210>  4080
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4080
caaggataac mattctcagc g                                               21


<210>  4081
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4081
ctgtgataaa kagcttgtgc a                                               21


<210>  4082
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4082
aagaaaatgc ktatattttt a                                               21


<210>  4083
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4083
tttaggtggc rtggttattt g                                               21


<210>  4084
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4084
ttgaggggaa rgatttgcct c                                               21


<210>  4085
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4085
ctctccatct staaggtggt t                                               21


<210>  4086
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4086
gccaggcctc ygaactgtac t                                               21


<210>  4087
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4087
ctagagctac rctgtccaat a                                               21


<210>  4088
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4088
ggtgtacggt rtggaagatt t                                               21


<210>  4089
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4089
gtagagaaca ytgacaggca g                                               21


<210>  4090
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4090
tgctgggaaa rgggcccttg a                                               21


<210>  4091
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4091
ccctgtataa sagacattgg a                                               21


<210>  4092
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4092
aggtgaagtt ygaaggatca c                                               21


<210>  4093
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4093
ctccaaggaa ygtagatagt g                                               21


<210>  4094
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4094
cagatgctat rctagatgct g                                               21


<210>  4095
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4095
atctgattat ytgtaacatt g                                               21


<210>  4096
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4096
gcatattaga maactccata t                                               21


<210>  4097
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4097
tttagaaaaa kataaaatct g                                               21


<210>  4098
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4098
taccagggat rcagttcctg g                                               21


<210>  4099
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4099
gtcacatcac ytataaaagt t                                               21


<210>  4100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4100
acaactcata ygaagatttt t                                               21


<210>  4101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4101
ctacaaactc ygattagcta c                                               21


<210>  4102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4102
ggttgaaata sgtaggaaag t                                               21


<210>  4103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4103
ctttatgact scttgacaca t                                               21


<210>  4104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4104
agcaggctgc rgctgaagtg c                                               21


<210>  4105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4105
actacagtaa rtcctcaagt c                                               21


<210>  4106
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4106
ggttcccttc ytccttccct g                                               21


<210>  4107
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4107
gcctggaacc stcaggccaa c                                               21


<210>  4108
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4108
agacaggcac racatgtttg g                                               21


<210>  4109
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4109
gtgcttgaaa rtatcatttc t                                               21


<210>  4110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4110
ctttctttct ytactctttc g                                               21


<210>  4111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4111
gcacattgag magtactatc t                                               21


<210>  4112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4112
tcatctgcct kgtgaaggga c                                               21


<210>  4113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4113
ggctccggga raatgccagt g                                               21


<210>  4114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4114
actgatggac wcatgtagat g                                               21


<210>  4115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4115
gaggaaatgg yctcagtgaa g                                               21


<210>  4116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4116
tcctatatac yctcaaacca c                                               21


<210>  4117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4117
cagaataatt mgtgcagaat c                                               21


<210>  4118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4118
accttggaac rtattatagt c                                               21


<210>  4119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4119
aaaattgtgg kgtacaaaga a                                               21


<210>  4120
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4120
gaaaaaaatc rtttgatcaa t                                               21


<210>  4121
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4121
aaatttcatg ytctggaaaa g                                               21


<210>  4122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4122
agtacaatgt kccatatcag a                                               21


<210>  4123
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4123
aacataacca raaaatataa t                                               21


<210>  4124
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4124
cctaggaata yaagttgtta a                                               21


<210>  4125
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4125
atacctgggc sagtctcaca t                                               21


<210>  4126
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4126
attcaaaaaa mggttagtaa g                                               21


<210>  4127
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4127
taaatagaaa yctactctgt g                                               21


<210>  4128
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4128
acgtgctagg rcctgaggag a                                               21


<210>  4129
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4129
cagtcaaatg sagcttagca a                                               21


<210>  4130
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4130
ccatgtaggg maacagccaa g                                               21


<210>  4131
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4131
cagagatacc rtccccgggt a                                               21


<210>  4132
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4132
agttgggccc raaagtcagc t                                               21


<210>  4133
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4133
caggtatgtt kaacacttag t                                               21


<210>  4134
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4134
agctgacaca yggctggagt c                                               21


<210>  4135
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4135
cagcattatc ycatcctgat a                                               21


<210>  4136
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4136
ccctcagttc rattggacac a                                               21


<210>  4137
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4137
taaggttgct rtgattctat c                                               21


<210>  4138
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4138
tcaaatactc rgcagttact g                                               21


<210>  4139
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4139
gcagggaaga raaatgcacc a                                               21


<210>  4140
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4140
gcagtctgtt ygggtctccc c                                               21


<210>  4141
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4141
cttgcttgct rttactaaga c                                               21


<210>  4142
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4142
gtggacactt yctcctggac c                                               21


<210>  4143
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4143
cctactatgc ygggtgccac t                                               21


<210>  4144
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4144
caaattgtat ytgatttctg c                                               21


<210>  4145
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4145
caggaaaagc sgagtgcgaa t                                               21


<210>  4146
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4146
gcagggaaag rcacagctca a                                               21


<210>  4147
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4147
gggtctgctt rtctgtggag a                                               21


<210>  4148
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4148
gctgcttcac rttgtacttt g                                               21


<210>  4149
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4149
gctcccttcc kcctcctttc t                                               21


<210>  4150
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4150
ctgtgcgttt ytcattaagc c                                               21


<210>  4151
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4151
caacccattt scaacatgac t                                               21


<210>  4152
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4152
ccaggccata wggtgtaacc t                                               21


<210>  4153
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4153
gtcttgatgt rcaaaatgtt c                                               21


<210>  4154
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4154
gcaaccaggg maaactagtt g                                               21


<210>  4155
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4155
tgttccctga ycccaagccc a                                               21


<210>  4156
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4156
ggctttggta kattttcata c                                               21


<210>  4157
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4157
caaagtcagc yggaaagaag t                                               21


<210>  4158
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4158
catttggtaa wgtctggaga c                                               21


<210>  4159
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4159
ctggtcccaa mctcctggct c                                               21


<210>  4160
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4160
ctgatttgca rccaagatgg a                                               21


<210>  4161
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4161
agggtcgtta ygctcatcat g                                               21


<210>  4162
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4162
ccagatagac rtggggctcc c                                               21


<210>  4163
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4163
caatttaacc raaaccttta g                                               21


<210>  4164
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4164
atataatttg ycaatctgga g                                               21


<210>  4165
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4165
ggaggcacag rccatttact g                                               21


<210>  4166
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4166
tctttccccg ytgacttctc c                                               21


<210>  4167
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4167
cctgcacttt ygggcccatc t                                               21


<210>  4168
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4168
aacttgggga ygatagtgct g                                               21


<210>  4169
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4169
gggttgtctt ytgcccatga c                                               21


<210>  4170
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4170
ttgttgtctt ygactttcaa a                                               21


<210>  4171
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4171
tcagtgactg yacaattttt t                                               21


<210>  4172
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4172
ctctcaccct yaaacatttc c                                               21


<210>  4173
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4173
ccatactgtt raaactttct c                                               21


<210>  4174
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4174
aaacggttct wctttgccaa g                                               21


<210>  4175
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4175
tatacttaac rcataagttt c                                               21


<210>  4176
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4176
atcagcgtca mccctctgct t                                               21


<210>  4177
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4177
ttcctcctcc rtcctccagg a                                               21


<210>  4178
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4178
tggccaacgc rgcggtctct g                                               21


<210>  4179
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4179
ggccaggtta yaacaagcat g                                               21


<210>  4180
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4180
ctggcaaagt stggaaggtg g                                               21


<210>  4181
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4181
aaattatgta rgaacttctc a                                               21


<210>  4182
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4182
acagaagtga sagagtgtgc a                                               21


<210>  4183
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4183
ttatgattcc ktcagtttaa a                                               21


<210>  4184
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4184
gtcctaaaga yaacttttcc c                                               21


<210>  4185
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4185
ctgtcatcca rtactctttg a                                               21


<210>  4186
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4186
aggagacatc satggagttc a                                               21


<210>  4187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4187
tcagaatcaa ygtatttaac t                                               21


<210>  4188
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4188
aaatgcctta kactcagccc a                                               21


<210>  4189
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4189
tttcatatta rgtaaaataa g                                               21


<210>  4190
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4190
catatggttt ygattgcaga g                                               21


<210>  4191
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4191
gtaccagaga ytgaattaca g                                               21


<210>  4192
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4192
ctccaaaaat ktgatcactt a                                               21


<210>  4193
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4193
catattgtcc ygctgttttt g                                               21


<210>  4194
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4194
agggtgactt sattcttgat g                                               21


<210>  4195
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4195
aggaacgaaa kaattaaacc t                                               21


<210>  4196
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4196
tacattataa wattaactca t                                               21


<210>  4197
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4197
gcccaaatag wggcaaaaat a                                               21


<210>  4198
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4198
aattaagtat rataatgtgg g                                               21


<210>  4199
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4199
gtattagtcc racggagaga a                                               21


<210>  4200
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4200
cttcattaat kgttactttt a                                               21


<210>  4201
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4201
ctccagggcc rttggctcag t                                               21


<210>  4202
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4202
tgctctgggg racttttgcc a                                               21


<210>  4203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4203
atattctaga ygctgagcca a                                               21


<210>  4204
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4204
tagtgctgtt wgccattctt a                                               21


<210>  4205
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4205
aagtgggata raagtctata c                                               21


<210>  4206
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4206
gtaaacaatt kaagtgcagg g                                               21


<210>  4207
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4207
cactgttatc ygcaacacag t                                               21


<210>  4208
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4208
aagatttgac rtgagttcat g                                               21


<210>  4209
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4209
agtatatcta rttatttggt a                                               21


<210>  4210
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4210
ttactgctta raaagagacc t                                               21


<210>  4211
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4211
tgattatgtt kttaatgagt a                                               21


<210>  4212
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4212
ctgttgcaac yaaaaaggcc a                                               21


<210>  4213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4213
aggatataaa yctttagtca t                                               21


<210>  4214
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4214
ttattcctct wtggtgcatc t                                               21


<210>  4215
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4215
ctgtaactta ytaacaattt t                                               21


<210>  4216
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4216
caaccatgct rgcatctgct t                                               21


<210>  4217
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4217
attgaattat rtctgtcaaa c                                               21


<210>  4218
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4218
catattcata yatatatcgt g                                               21


<210>  4219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4219
ttgccagaac mactgtatga a                                               21


<210>  4220
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4220
gattgtgtaa racatctttt a                                               21


<210>  4221
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4221
agtaacaaca ytggtaagca a                                               21


<210>  4222
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4222
taaagtttcc wtgcaaattt g                                               21


<210>  4223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4223
actgcttatc rtttgctaag a                                               21


<210>  4224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4224
gtgtattagc stgttaaaga t                                               21


<210>  4225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4225
gcgttatttg rccattctta t                                               21


<210>  4226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4226
aatattaacc yggctctaga g                                               21


<210>  4227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4227
cacatttctt rgcattgaaa t                                               21


<210>  4228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4228
gaataaaatg ytgttttaga g                                               21


<210>  4229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4229
tgttgatata ytgagtgttt t                                               21


<210>  4230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4230
tttaaaaaat kcaccattat a                                               21


<210>  4231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4231
tgtggtgggt rtactattaa a                                               21


<210>  4232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4232
acccaggtac mtaaaggcag t                                               21


<210>  4233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4233
ctgttagtaa ycatcacagt t                                               21


<210>  4234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4234
ctgtgatgaa yagggatgaa c                                               21


<210>  4235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4235
attagagcta ygttttagca a                                               21


<210>  4236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4236
tgagagacat rtgcttgcaa t                                               21


<210>  4237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4237
acatctttgc rataagccct t                                               21


<210>  4238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4238
tgctgtcaca rgaatgagtg g                                               21


<210>  4239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4239
tttcacaaac wcttttccac a                                               21


<210>  4240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4240
tgcggtccta rtaattcaca c                                               21


<210>  4241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4241
gagaagagcc kgcatgcccc a                                               21


<210>  4242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4242
ttgagttatt yttttgacag g                                               21


<210>  4243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4243
ggtgacatgc ytgttttctc t                                               21


<210>  4244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4244
gtgtcaacta ytgggagtgc c                                               21


<210>  4245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4245
acttctacaa ygtcatatag g                                               21


<210>  4246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4246
aaactagatt rgaagataat c                                               21


<210>  4247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4247
tttataattt waaaaaatag c                                               21


<210>  4248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4248
atctgaggaa ycaagaggtt a                                               21


<210>  4249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4249
tgtccaggag ytgggtttct a                                               21


<210>  4250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4250
ggggtggaat rgtgacattt g                                               21


<210>  4251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4251
aaagccatca maatgaataa t                                               21


<210>  4252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4252
tatgcttact ytttatatgt t                                               21


<210>  4253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4253
caaaatgagt macagttttt a                                               21


<210>  4254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4254
gacgtcatac wtcagattcc t                                               21


<210>  4255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4255
acacaagtgg kagaagaaaa a                                               21


<210>  4256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4256
tctaatggct yagattgtct t                                               21


<210>  4257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4257
atggactttt kccctaggac g                                               21


<210>  4258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4258
gcaaaatgta raagaaaaat a                                               21


<210>  4259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4259
tgaatggcca ygggtaatga t                                               21


<210>  4260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4260
tttacctcca yttattcatt c                                               21


<210>  4261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4261
ggcaggagtt ygtcacctac c                                               21


<210>  4262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4262
tagtatttac rcaaaactgt c                                               21


<210>  4263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4263
aaaattatga yggttccatt g                                               21


<210>  4264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4264
aatagtaaaa mctgtaatat t                                               21


<210>  4265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4265
acagctagaa ycagtttcag t                                               21


<210>  4266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4266
aactgttaga kaaattttcc g                                               21


<210>  4267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4267
atcatgacca rtaaagttat c                                               21


<210>  4268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4268
ttgtaaatta ygtggtttag a                                               21


<210>  4269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4269
tgattatcta mcaatctgag c                                               21


<210>  4270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4270
ttttttgcaa statacttag a                                               21


<210>  4271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4271
gtattgtagg sagcatgatt g                                               21


<210>  4272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4272
aatttataca rctatagcag g                                               21


<210>  4273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4273
taaggctgcc rtaaaaaatc a                                               21


<210>  4274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4274
tgttactaat rtgggttaca t                                               21


<210>  4275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4275
tgtgagggtt wtcaataagc a                                               21


<210>  4276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4276
ctactaccat ycttgtcttt g                                               21


<210>  4277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4277
tcttctatta kttatttatt t                                               21


<210>  4278
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4278
caaatatcaa ygtgaggttt g                                               21


<210>  4279
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4279
aattagacaa yctgcgtagt g                                               21


<210>  4280
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4280
catggaaacc rgcaaaaaac g                                               21


<210>  4281
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4281
aaacagaaag rcatggaaat g                                               21


<210>  4282
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4282
acataatggg ragccagctt t                                               21


<210>  4283
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4283
ccaaccccac rgccaggttt t                                               21


<210>  4284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4284
tatttagaaa wgagccgcaa t                                               21


<210>  4285
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4285
gtgtgaaggg yggacggaga g                                               21


<210>  4286
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4286
gaatacgaag ygaagcgcta a                                               21


<210>  4287
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4287
taggggacat rtaactctct t                                               21


<210>  4288
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4288
gtaataaaat ygtcaaaaat a                                               21


<210>  4289
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4289
tgtggttgtc mgcctgaaag a                                               21


<210>  4290
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4290
atatagcaat wctctaaatt t                                               21


<210>  4291
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4291
ccaaaggaca ycctggaaac t                                               21


<210>  4292
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4292
attaggaata ygcaaacatt a                                               21


<210>  4293
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4293
ataagggtgc kagaccaaga t                                               21


<210>  4294
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4294
tcctcattca raattgttat t                                               21


<210>  4295
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4295
gttgccagca ytcagagcct c                                               21


<210>  4296
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4296
tagtatgtac mtagttttga c                                               21


<210>  4297
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4297
taaaatttgt yaaattgttt c                                               21


<210>  4298
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4298
ctgaagacca ycctgttgct a                                               21


<210>  4299
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4299
ggcatattac raaggcctgg g                                               21


<210>  4300
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4300
cagcccataa sagattctca a                                               21


<210>  4301
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4301
tgaggtcaaa ygtcacgcat t                                               21


<210>  4302
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4302
taaattatga rcttttacat g                                               21


<210>  4303
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4303
tagtgagagc raggacacag g                                               21


<210>  4304
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4304
atgtttttca matcccttcc a                                               21


<210>  4305
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4305
acctactgac mcctttgaaa t                                               21


<210>  4306
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4306
tgacaaggaa ragagaatag g                                               21


<210>  4307
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4307
gactgcccgg ygatcttttt g                                               21


<210>  4308
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4308
tgttgtgcat rgcacctagt a                                               21


<210>  4309
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4309
tctgtgataa ygacatggtt g                                               21


<210>  4310
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4310
tcttacattc wtgggcactc c                                               21


<210>  4311
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4311
ttatttagag sctaattttc a                                               21


<210>  4312
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4312
tgggttgtgt rtgtttcttc t                                               21


<210>  4313
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4313
agattccctc mgtcctgtag a                                               21


<210>  4314
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4314
tcaatccttt yccccagggt t                                               21


<210>  4315
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4315
ggaatataat ktgctcctta c                                               21


<210>  4316
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4316
atatattgcc rcagaattaa a                                               21


<210>  4317
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4317
tgttttcctg katagttata g                                               21


<210>  4318
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4318
tcttactcta magtcattat t                                               21


<210>  4319
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4319
aatgtgtgaa saagtttata a                                               21


<210>  4320
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4320
catcgtgaag sggcttctcc a                                               21


<210>  4321
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4321
gcttatagca rgttacccag a                                               21


<210>  4322
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4322
taaatgtgct stagcagttg a                                               21


<210>  4323
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4323
tctaatactg ygcaccaaaa a                                               21


<210>  4324
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4324
gcaggtgtct rccaccatga t                                               21


<210>  4325
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4325
catggccagc satctgaaag a                                               21


<210>  4326
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4326
cactaattac rccaactaat t                                               21


<210>  4327
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4327
atcaccatgc rtcattacac a                                               21


<210>  4328
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4328
ctcctccact rtgacttcct a                                               21


<210>  4329
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4329
catttactac ytgtccactt c                                               21


<210>  4330
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4330
tacagcttcc rgtaacccaa a                                               21


<210>  4331
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4331
cgggttttat ygtttaaaaa t                                               21


<210>  4332
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4332
aactaagaac wgagcatcca c                                               21


<210>  4333
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4333
taatcaccac rgaacacttt t                                               21


<210>  4334
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4334
tcccctcaca sctcctcaaa t                                               21


<210>  4335
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4335
cgacttgacc rtgaatgagg t                                               21


<210>  4336
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4336
tatgtttcca ytggacagca c                                               21


<210>  4337
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4337
accaacaaac rtcatactga a                                               21


<210>  4338
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4338
gagaggccac rttttttatt t                                               21


<210>  4339
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4339
agcctttcac raagacagcc a                                               21


<210>  4340
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4340
caaaacaatt mggaagcgat g                                               21


<210>  4341
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4341
taaattagta scagggagtg c                                               21


<210>  4342
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4342
tgaagctggt raatctcact t                                               21


<210>  4343
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4343
attaaagttt ytgaaagcaa t                                               21


<210>  4344
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4344
aaattacccc rtataatggt c                                               21


<210>  4345
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4345
ccctcgatga yttcctctgc c                                               21


<210>  4346
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4346
gctttggtga yagacactga g                                               21


<210>  4347
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4347
tctgtgtgca stttgggaaa a                                               21


<210>  4348
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4348
gttaaacata kttttcagac t                                               21


<210>  4349
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4349
ggggtgttga yatctcaccg c                                               21


<210>  4350
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4350
gagtcacatc rtcacttcct g                                               21


<210>  4351
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4351
tataaaacac satcattctg t                                               21


<210>  4352
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4352
gctactttgc rtaagaggtg c                                               21


<210>  4353
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4353
gtcatttgta yttatgacag c                                               21


<210>  4354
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4354
ggagtgccac maactatgct t                                               21


<210>  4355
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4355
agcgggtcct yggcacttga a                                               21


<210>  4356
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4356
tgtgagtgat yctttttaaa c                                               21


<210>  4357
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4357
ttgtccttct ktagcatgtg t                                               21


<210>  4358
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4358
cttggccaat yttcatattt c                                               21


<210>  4359
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4359
gacatctaga yatgttcagt c                                               21


<210>  4360
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4360
tatatgacaa yactcatcac a                                               21


<210>  4361
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4361
tgttgttttt kggggaaaga a                                               21


<210>  4362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4362
ccaatggagt ragcccagaa c                                               21


<210>  4363
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4363
tcaagaaaaa ygcccagaca a                                               21


<210>  4364
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4364
gaaaatgaga yctctacccc a                                               21


<210>  4365
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4365
atgatatcta rgcaaatatt t                                               21


<210>  4366
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4366
ttatggaaat saagattcaa c                                               21


<210>  4367
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4367
catagatatt kgcatgaaca a                                               21


<210>  4368
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4368
tgggatgcct rgcacaaagg a                                               21


<210>  4369
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4369
tcctcacttg rcatgtatct g                                               21


<210>  4370
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4370
gcaaggcatg raaaactaga g                                               21


<210>  4371
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4371
ggatactttc wggattggag a                                               21


<210>  4372
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4372
aattcttcag staggggagt a                                               21


<210>  4373
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4373
ccagcaaata ygaggacttc a                                               21


<210>  4374
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4374
ataatatgtg wttccattta g                                               21


<210>  4375
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4375
ataatagaag rgttcattca g                                               21


<210>  4376
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4376
aataggaaaa rtgtttggtc c                                               21


<210>  4377
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4377
cctgttagat kctccacaac a                                               21


<210>  4378
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4378
ttgcaactgc kgattgaaaa c                                               21


<210>  4379
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4379
tattggaaaa rtacaaacca g                                               21


<210>  4380
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4380
tcacagtttg sctgctttat c                                               21


<210>  4381
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4381
aaactacagg mtaacccaga a                                               21


<210>  4382
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4382
tctggaccca rtcagagtct g                                               21


<210>  4383
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4383
atttcactag saagttaagc a                                               21


<210>  4384
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4384
tggaaaacta ycataaaaga a                                               21


<210>  4385
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4385
aggactcggt rcctttctga a                                               21


<210>  4386
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4386
aatgactcta ygtaaaactg a                                               21


<210>  4387
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4387
tgggaatcta wtctcatctc c                                               21


<210>  4388
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4388
tatctgagtc rgagtcttga t                                               21


<210>  4389
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4389
agcatttatt rtgatcaatt a                                               21


<210>  4390
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4390
gctgggatta ygagttcaga g                                               21


<210>  4391
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4391
aaccaagttt yagagtaaga a                                               21


<210>  4392
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4392
gatgatgtat ygtttttgct t                                               21


<210>  4393
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4393
tttagtattc rgtatgacat t                                               21


<210>  4394
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4394
atgtttatcc rtatgcattt a                                               21


<210>  4395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4395
tcagtaaata ygtggtagaa t                                               21


<210>  4396
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4396
gttggtgttt sttatattaa c                                               21


<210>  4397
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4397
ggaattagcc rttacaaact t                                               21


<210>  4398
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4398
aaaatatccc raggcattaa g                                               21


<210>  4399
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4399
aaagtgctca ygtatatatg t                                               21


<210>  4400
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4400
aacttcctac rctgtctaca g                                               21


<210>  4401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4401
aacagaaatt ytggagcagg a                                               21


<210>  4402
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4402
ctcatctact yagccctgcc t                                               21


<210>  4403
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4403
tgactccata ygtttcagag a                                               21


<210>  4404
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4404
agtaagaaca ygcctcataa t                                               21


<210>  4405
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4405
attgggtcag rtccataatc c                                               21


<210>  4406
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4406
ctagttatag yaaaaggtct g                                               21


<210>  4407
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4407
cttaactgtt yacctaactg a                                               21


<210>  4408
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4408
gaaataatga rcatttgagc c                                               21


<210>  4409
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4409
ttgattaatc maaattgcca a                                               21


<210>  4410
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4410
tttgtgcact kccattagaa a                                               21


<210>  4411
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4411
ttggatactg yggtagaaga t                                               21


<210>  4412
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4412
aaactattaa waaattcaaa a                                               21


<210>  4413
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4413
tgataagttc ygtgttctgt c                                               21


<210>  4414
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4414
gtactgttaa maactatatc c                                               21


<210>  4415
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4415
caattaatag yttggccacc a                                               21


<210>  4416
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4416
agattggttg raaaaaaagt g                                               21


<210>  4417
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4417
tcttttcata wtttttccta c                                               21


