                         SEQUENCE LISTING

<110>  PATTI, JOSEPH M
 
<120>  MONOCLONAL ANTIBODIES RECOGNIZING THE ENTEROCOCCUS FAECIUM ACM 
       PROTEIN

<130>  P09148WO00/BAS

<150>  60/885,693
<151>  2007-01-19

<150>  60/886,125
<151>  2007-01-23

<160>  6     

<170>  PatentIn version 3.2

<210>  1
<211>  2700
<212>  DNA
<213>  Enterococcus faecium

<400>  1
tctaaataaa gaaacagatg tttctttata ttgtatttta tcctttaatt aacacaaaaa     60

cagctagtat aaactaataa tgttaattaa aagtgtattt tatgaaacta tcgttattta    120

ttaatgttgc atttttgtaa gttaaaaatt ggaaatatag attgaaaaaa tgaaagcaat    180

aagtaaaata aaatgaatat atgcgaaaaa ataatttaca ttaggaaaaa ccttgtaaaa    240

acagtttttt ggcatattta ttttttataa atatttgtaa aataactatc aattttttag    300

ttaaaagatt ggaaatgagt gggggaggaa ttgaagaaag gatttttgag agatgatata    360

gtaggtttta tttttagtta aaatagggga gatagaaaaa atgaaaaagt gtagaaatat    420

tattttatca atgttattta ttattactaa tataacatca ctgattcctg ttcatgtcta    480

tgcggatgca ggcagagata tcagcagtaa tgtcacttcg ttgaccgtgg acccaacgaa    540

tattacagat ggaggaaaca taaaagtaaa attctcgttt gacgaaaaaa aacaaaatat    600

ccaaccaggt gattatcttt ggatcaattg gccaagtgaa ggaaatattc gcggtgaagg    660

attccaaaaa gaaatcccat taatgattga aaataaaaat gttggaactt taacggtcag    720

aaaagattct gcgcaggttg tgtttaatga aaatattaaa aacctagact cagtagaagg    780

ttgggggcaa tttgagatac aggccagaaa cgtaaccgat accggtgaag aaaatacggg    840

accattcacc gtgacgagcg gtgataaaac agctactgta aatgtgacaa agccagcttc    900

tggttcttct tctagcgttt tttattataa aacaggagac atgctacctg aagatactaa    960

gcacattcga tggtttttga atattaacaa taacggcact tatgttgaac aaccagttaa   1020

aatcagtgat gaaatccaaa gtggacaaag attagatcca agtacgtttg aaattaatca   1080

aatacactta ggtgaacaga aggtttatag aggagaagag ggaatccaac aatttttaca   1140

agatttcccc agcgctacat ttaatttttc agtaactgat aattacattg aaataactat   1200

accaaaaaac tttgtcaatc ttaggaaaat aatggtgagt tataagacga tcatagaaaa   1260

cccagaacaa ataaattttg agaatcattc ggaagcttgg tttaaagaat ttaataaacc   1320

tgctgttgat ggagaaagtt tcaatcatac agttaaaaat atttcagctt ctggtggagt   1380

caacggtaca gttagaggcg aattgaagat tttcaaatat atcaatgaca cagagattgg   1440

tatcccaaat gtgactttcg aattaagacg agcagatgaa cagcctattc aaggacagtc   1500

tagtatcctg ttgacttcga atgaacaggg agaagctagt atcaaaggcc tgcaagtagg   1560

agactatgtt gtaaaagaaa aagaagcacc caattggatt gattttgatc cactaagttc   1620

aaatgaactc aaattctcca taaacgaaaa tgatacagag ggagtcagtt tacctattta   1680

taacaagaaa aaggttacga acatcacagc aactaaaatt tggaacggtg gaaccactcc   1740

aagaccgagt atttatttta aattattcag agcaagtaca aacaattggg aaccagttcc   1800

tgatgcagaa acaaaacgat tagacaatgg aataacttca gtgacttggg aagatatcca   1860

acagtatgat gatagtggaa acgaatatac gtttaaagtg caagaagtag atcaaaacgg   1920

aaatgattat gtcccttcag gttatcaaaa aattgaaaac gggctagtcg ttacaaatga   1980

gaataaagaa gtcatttcag tctcaggaca aaaaacatgg gaagacaatg agaaccaaga   2040

cggcaaacga ccgacgacga tcacagtaaa tctattagcc gacggtcaac cgatccaaca   2100

caaagaagta agtgaaaaag atgattggcg ctatcgtttc acaaatctgc caaaatacag   2160

agacgggcaa gaaatcatct atactgtaac ggaagacaac gtgcccgaat acagtacgac   2220

gattgacggg tataacatca aaaacagtta tacaccggaa aaaacaaata tatctatacc   2280

aggtagccat ataacaccgt ggaaaaattt tccagagaag acagagagag agaaaattag   2340

aaatctattc tctcaaaaat tgcaaatatt tgctcataca ggagaatcca gcgaacaaag   2400

aagcaattat attagtaaga gagctgtacc taaacagata acaaataaat caaaaagcat   2460

tcttcctaaa acaagtagta aaaaatctag ttttgctgta atcattggtt tattgatagt   2520

aactatctgt gctgggatat tcttacaaaa atataaaaaa gtttagttag aatataatat   2580

tttttgttaa atatgactga aatcaaaaga ataaaattcc gatttataat cgaaaaaaga   2640

agcattttta tatatgcttc ttttttcgta gaatcaataa atatggattt ggctaactat   2700


<210>  2
<211>  721
<212>  PRT
<213>  Enterococcus faecium

<400>  2

Met Lys Lys Cys Arg Asn Ile Ile Leu Ser Met Leu Phe Ile Ile Thr 
1               5                   10                  15      


Asn Ile Thr Ser Leu Ile Pro Val His Val Tyr Ala Asp Ala Gly Arg 
            20                  25                  30          


Asp Ile Ser Ser Asn Val Thr Ser Leu Thr Val Asp Pro Thr Asn Ile 
        35                  40                  45              


Thr Asp Gly Gly Asn Ile Lys Val Lys Phe Ser Phe Asp Glu Lys Lys 
    50                  55                  60                  


Gln Asn Ile Gln Pro Gly Asp Tyr Leu Trp Ile Asn Trp Pro Ser Glu 
65                  70                  75                  80  


Gly Asn Ile Arg Gly Glu Gly Phe Gln Lys Glu Ile Pro Leu Met Ile 
                85                  90                  95      


Glu Asn Lys Asn Val Gly Thr Leu Thr Val Arg Lys Asp Ser Ala Gln 
            100                 105                 110         


Val Val Phe Asn Glu Asn Ile Lys Asn Leu Asp Ser Val Glu Gly Trp 
        115                 120                 125             


Gly Gln Phe Glu Ile Gln Ala Arg Asn Val Thr Asp Thr Gly Glu Glu 
    130                 135                 140                 


Asn Thr Gly Pro Phe Thr Val Thr Ser Gly Asp Lys Thr Ala Thr Val 
145                 150                 155                 160 


Asn Val Thr Lys Pro Ala Ser Gly Ser Ser Ser Ser Val Phe Tyr Tyr 
                165                 170                 175     


Lys Thr Gly Asp Met Leu Pro Glu Asp Thr Lys His Ile Arg Trp Phe 
            180                 185                 190         


Leu Asn Ile Asn Asn Asn Gly Thr Tyr Val Glu Gln Pro Val Lys Ile 
        195                 200                 205             


Ser Asp Glu Ile Gln Ser Gly Gln Arg Leu Asp Pro Ser Thr Phe Glu 
    210                 215                 220                 


Ile Asn Gln Ile His Leu Gly Glu Gln Lys Val Tyr Arg Gly Glu Glu 
225                 230                 235                 240 


Gly Ile Gln Gln Phe Leu Gln Asp Phe Pro Ser Ala Thr Phe Asn Phe 
                245                 250                 255     


Ser Val Thr Asp Asn Tyr Ile Glu Ile Thr Ile Pro Lys Asn Phe Val 
            260                 265                 270         


Asn Leu Arg Lys Ile Met Val Ser Tyr Lys Thr Ile Ile Glu Asn Pro 
        275                 280                 285             


Glu Gln Ile Asn Phe Glu Asn His Ser Glu Ala Trp Phe Lys Glu Phe 
    290                 295                 300                 


Asn Lys Pro Ala Val Asp Gly Glu Ser Phe Asn His Thr Val Lys Asn 
305                 310                 315                 320 


Ile Ser Ala Ser Gly Gly Val Asn Gly Thr Val Arg Gly Glu Leu Lys 
                325                 330                 335     


Ile Phe Lys Tyr Ile Asn Asp Thr Glu Ile Gly Ile Pro Asn Val Thr 
            340                 345                 350         


Phe Glu Leu Arg Arg Ala Asp Glu Gln Pro Ile Gln Gly Gln Ser Ser 
        355                 360                 365             


Ile Leu Leu Thr Ser Asn Glu Gln Gly Glu Ala Ser Ile Lys Gly Leu 
    370                 375                 380                 


Gln Val Gly Asp Tyr Val Val Lys Glu Lys Glu Ala Pro Asn Trp Ile 
385                 390                 395                 400 


Asp Phe Asp Pro Leu Ser Ser Asn Glu Leu Lys Phe Ser Ile Asn Glu 
                405                 410                 415     


Asn Asp Thr Glu Gly Val Ser Leu Pro Ile Tyr Asn Lys Lys Lys Val 
            420                 425                 430         


Thr Asn Ile Thr Ala Thr Lys Ile Trp Asn Gly Gly Thr Thr Pro Arg 
        435                 440                 445             


Pro Ser Ile Tyr Phe Lys Leu Phe Arg Ala Ser Thr Asn Asn Trp Glu 
    450                 455                 460                 


Pro Val Pro Asp Ala Glu Thr Lys Arg Leu Asp Asn Gly Ile Thr Ser 
465                 470                 475                 480 


Val Thr Trp Glu Asp Ile Gln Gln Tyr Asp Asp Ser Gly Asn Glu Tyr 
                485                 490                 495     


Thr Phe Lys Val Gln Glu Val Asp Gln Asn Gly Asn Asp Tyr Val Pro 
            500                 505                 510         


Ser Gly Tyr Gln Lys Ile Glu Asn Gly Leu Val Val Thr Asn Glu Asn 
        515                 520                 525             


Lys Glu Val Ile Ser Val Ser Gly Gln Lys Thr Trp Glu Asp Asn Glu 
    530                 535                 540                 


Asn Gln Asp Gly Lys Arg Pro Thr Thr Ile Thr Val Asn Leu Leu Ala 
545                 550                 555                 560 


Asp Gly Gln Pro Ile Gln His Lys Glu Val Ser Glu Lys Asp Asp Trp 
                565                 570                 575     


Arg Tyr Arg Phe Thr Asn Leu Pro Lys Tyr Arg Asp Gly Gln Glu Ile 
            580                 585                 590         


Ile Tyr Thr Val Thr Glu Asp Asn Val Pro Glu Tyr Ser Thr Thr Ile 
        595                 600                 605             


Asp Gly Tyr Asn Ile Lys Asn Ser Tyr Thr Pro Glu Lys Thr Asn Ile 
    610                 615                 620                 


Ser Ile Pro Gly Ser His Ile Thr Pro Trp Lys Asn Phe Pro Glu Lys 
625                 630                 635                 640 


Thr Glu Arg Glu Lys Ile Arg Asn Leu Phe Ser Gln Lys Leu Gln Ile 
                645                 650                 655     


Phe Ala His Thr Gly Glu Ser Ser Glu Gln Arg Ser Asn Tyr Ile Ser 
            660                 665                 670         


Lys Arg Ala Val Pro Lys Gln Ile Thr Asn Lys Ser Lys Ser Ile Leu 
        675                 680                 685             


Pro Lys Thr Ser Ser Lys Lys Ser Ser Phe Ala Val Ile Ile Gly Leu 
    690                 695                 700                 


Leu Ile Val Thr Ile Cys Ala Gly Ile Phe Leu Gln Lys Tyr Lys Lys 
705                 710                 715                 720 


Val 
    


<210>  3
<211>  1505
<212>  DNA
<213>  Enterococcus faecium

<400>  3
atgcaggcag agatatcagc agtaatgtca cttcgttgac cgtggaccca acgaatatta     60

cagatggagg aaacataaaa gtaaaattct cgtttgacga aaaaaaacaa aatatccaac    120

caggtgatta tctttggatc aattggccaa gtgaaggaaa tattcgcggt gaaggattcc    180

aaaaagaaat cccattaatg attgaaaata aaaatgttgg aactttaacg gtcagaaaag    240

attctgcgca ggttgtgttt aatgaaaata ttaaaaacct agactcagta gaaggttggg    300

ggcaatttga gatacaggcc agaaacgtaa ccgataccgg tgaagaaaat acgggaccat    360

tcaccgtgac gagcggtgat aaaacagcta ctgtaaatgt gacaaagcca gcttctggtt    420

cttcttctag cgttttttat tataaaacag gagacatgct acctgaagat actaagcaca    480

ttcgatggtt tttgaatatt aacaataacg gcacttatgt tgaacaacca gttaaaatca    540

gtgatgaaat ccaaagtgga caaagattag atccaagtac gtttgaaatt aatcaaatac    600

acttaggtga acagaaggtt tatagaggag aagagggaat ccaacaattt ttacaagatt    660

tccccagcgc tacatttaat ttttcagtaa ctgataatta cattgaaata actataccaa    720

aaaactttgt caatcttagg aaaataatgg tgagttataa gacgatcata gaaaacccag    780

aacaaataaa ttttgagaat cattcggaag cttggtttaa agaatttaat aaacctgctg    840

ttgatggaga aagtttcaat catacagtta aaaatatttc agcttctggt ggagtcaacg    900

gtacagttag aggcgaattg aagattttca aatatatcaa tgacacagag attggtatcc    960

caaatgtgac tttcgaatta agacgagcag atgaacagcc tattcaagga cagtctagta   1020

tcctgttgac ttcgaatgaa cagggagaag ctagtatcaa aggcctgcaa gtaggagact   1080

atgttgtaaa agaaaaagaa gcacccaatt ggattgattt tgatccacta agttcaaatg   1140

aactcaaatt ctccataaac gaaaatgata cagagggagt cagtttacct atttataaca   1200

agaaaaaggt tacgaacatc acagcaacta aaatttggaa cggtggaacc actccaagac   1260

cgagtattta ttttaaatta ttcagagcaa gtacaaacaa ttgggaacca gttcctgatg   1320

cagaaacaaa acgattagac aatggaataa cttcagtgac ttgggaagat atccaacagt   1380

atgatgatag tggaaacgaa tatacgttta aagtgcaaga agtagatcaa aacggaaatg   1440

attatgtccc ttcaggttat caaaaaattg aaaacgggct agtcgttaca aatgagaata   1500

aatag                                                               1505


<210>  4
<211>  513
<212>  PRT
<213>  Enterococcus faecium

<400>  4

Met Arg Gly Ser His His His His His His Gly Ser Asp Ala Gly Arg 
1               5                   10                  15      


Asp Ile Ser Ser Asn Val Thr Ser Leu Thr Val Asp Pro Thr Asn Ile 
            20                  25                  30          


Thr Asp Gly Gly Asn Ile Lys Val Lys Phe Ser Phe Asp Glu Lys Lys 
        35                  40                  45              


Gln Asn Ile Gln Pro Gly Asp Tyr Leu Trp Ile Asn Trp Pro Ser Glu 
    50                  55                  60                  


Gly Asn Ile Arg Gly Glu Gly Phe Gln Lys Glu Ile Pro Leu Met Ile 
65                  70                  75                  80  


Glu Asn Lys Asn Val Gly Thr Leu Thr Val Arg Lys Asp Ser Ala Gln 
                85                  90                  95      


Val Val Phe Asn Glu Asn Ile Lys Asn Leu Asp Ser Val Glu Gly Trp 
            100                 105                 110         


Gly Gln Phe Glu Ile Gln Ala Arg Asn Val Thr Asp Thr Gly Glu Glu 
        115                 120                 125             


Asn Thr Gly Pro Phe Thr Val Thr Ser Gly Asp Lys Thr Ala Thr Val 
    130                 135                 140                 


Asn Val Thr Lys Pro Ala Ser Gly Ser Ser Ser Ser Val Phe Tyr Tyr 
145                 150                 155                 160 


Lys Thr Gly Asp Met Leu Pro Glu Asp Thr Lys His Ile Arg Trp Phe 
                165                 170                 175     


Leu Asn Ile Asn Asn Asn Gly Thr Tyr Val Glu Gln Pro Val Lys Ile 
            180                 185                 190         


Ser Asp Glu Ile Gln Ser Gly Gln Arg Leu Asp Pro Ser Thr Phe Glu 
        195                 200                 205             


Ile Asn Gln Ile His Leu Gly Glu Gln Lys Val Tyr Arg Gly Glu Glu 
    210                 215                 220                 


Gly Ile Gln Gln Phe Leu Gln Asp Phe Pro Ser Ala Thr Phe Asn Phe 
225                 230                 235                 240 


Ser Val Thr Asp Asn Tyr Ile Glu Ile Thr Ile Pro Lys Asn Phe Val 
                245                 250                 255     


Asn Leu Arg Lys Ile Met Val Ser Tyr Lys Thr Ile Ile Glu Asn Pro 
            260                 265                 270         


Glu Gln Ile Asn Phe Glu Asn His Ser Glu Ala Trp Phe Lys Glu Phe 
        275                 280                 285             


Asn Lys Pro Ala Val Asp Gly Glu Ser Phe Asn His Thr Val Lys Asn 
    290                 295                 300                 


Ile Ser Ala Ser Gly Gly Val Asn Gly Thr Val Arg Gly Glu Leu Lys 
305                 310                 315                 320 


Ile Phe Lys Tyr Ile Asn Asp Thr Glu Ile Gly Ile Pro Asn Val Thr 
                325                 330                 335     


Phe Glu Leu Arg Arg Ala Asp Glu Gln Pro Ile Gln Gly Gln Ser Ser 
            340                 345                 350         


Ile Leu Leu Thr Ser Asn Glu Gln Gly Glu Ala Ser Ile Lys Gly Leu 
        355                 360                 365             


Gln Val Gly Asp Tyr Val Val Lys Glu Lys Glu Ala Pro Asn Trp Ile 
    370                 375                 380                 


Asp Phe Asp Pro Leu Ser Ser Asn Glu Leu Lys Phe Ser Ile Asn Glu 
385                 390                 395                 400 


Asn Asp Thr Glu Gly Val Ser Leu Pro Ile Tyr Asn Lys Lys Lys Val 
                405                 410                 415     


Thr Asn Ile Thr Ala Thr Lys Ile Trp Asn Gly Gly Thr Thr Pro Arg 
            420                 425                 430         


Pro Ser Ile Tyr Phe Lys Leu Phe Arg Ala Ser Thr Asn Asn Trp Glu 
        435                 440                 445             


Pro Val Pro Asp Ala Glu Thr Lys Arg Leu Asp Asn Gly Ile Thr Ser 
    450                 455                 460                 


Val Thr Trp Glu Asp Ile Gln Gln Tyr Asp Asp Ser Gly Asn Glu Tyr 
465                 470                 475                 480 


Thr Phe Lys Val Gln Glu Val Asp Gln Asn Gly Asn Asp Tyr Val Pro 
                485                 490                 495     


Ser Gly Tyr Gln Lys Ile Glu Asn Gly Leu Val Val Thr Asn Glu Asn 
            500                 505                 510         


Lys 
    


<210>  5
<211>  1469
<212>  DNA
<213>  Enterococcus faecium

<400>  5
tgaccgtgga cccaacgaat attacagatg gaggaaacat aaaagtaaaa ttctcgtttg     60

acgaaaaaaa acaaaatatc caaccaggtg attatctttg gatcaattgg ccaagtgaag    120

gaaatattcg cggtgaagga ttccaaaaag aaatcccatt aatgattgaa aataaaaatg    180

ttggaacttt aacggtcaga aaagattctg cgcaggttgt gtttaatgaa aatattaaaa    240

acctagactc agtagaaggt tgggggcaat ttgagataca ggccagaaac gtaaccgata    300

ccggtgaaga aaatacggga ccattcaccg tgacgagcgg tgataaaaca gctactgtaa    360

atgtgacaaa gccagcttct ggttcttctt ctagcgtttt ttattataaa acaggagaca    420

tgctacctga agatactaag cacattcgat ggtttttgaa tattaacaat aacggcactt    480

atgttgaaca accagttaaa atcagtgatg aaatccaaag tggacaaaga ttagatccaa    540

gtacgtttga aattaatcaa atacacttag gtgaacagaa ggtttataga ggagaagagg    600

gaatccaaca atttttacaa gatttcccca gcgctacatt taatttttca gtaactgata    660

attacattga aataactata ccaaaaaact ttgtcaatct taggaaaata atggtgagtt    720

ataagacgat catagaaaac ccagaacaaa taaattttga gaatcattcg gaagcttggt    780

ttaaagaatt taataaacct gctgttgatg gagaaagttt caatcataca gttaaaaata    840

tttcagcttc tggtggagtc aacggtacag ttagaggcga attgaagatt ttcaaatata    900

tcaatgacac agagattggt atcccaaatg tgactttcga attaagacga gcagatgaac    960

agcctattca aggacagtct agtatcctgt tgacttcgaa tgaacaggga gaagctagta   1020

tcaaaggcct gcaagtagga gactatgttg taaaagaaaa agaagcaccc aattggattg   1080

attttgatcc actaagttca aatgaactca aattctccat aaacgaaaat gatacagagg   1140

gagtcagttt acctatttat aacaagaaaa aggttacgaa catcacagca actaaaattt   1200

ggaacggtgg aaccactcca agaccgagta tttattttaa attattcaga gcaagtacaa   1260

acaattggga accagttcct gatgcagaaa caaaacgatt agacaatgga ataacttcag   1320

tgacttggga agatatccaa cagtatgatg atagtggaaa cgaatatacg tttaaagtgc   1380

aagaagtaga tcaaaacgga aatgattatg tcccttcagg ttatcaaaaa attgaaaacg   1440

ggctagtcgt tacaaatgag aataaatag                                     1469


<210>  6
<211>  501
<212>  PRT
<213>  Enterococcus faecium

<400>  6

Asp Ala Gly Arg Asp Ile Ser Ser Asn Val Thr Ser Leu Thr Val Asp 
1               5                   10                  15      


Pro Thr Asn Ile Thr Asp Gly Gly Asn Ile Lys Val Lys Phe Ser Phe 
            20                  25                  30          


Asp Glu Lys Lys Gln Asn Ile Gln Pro Gly Asp Tyr Leu Trp Ile Asn 
        35                  40                  45              


Trp Pro Ser Glu Gly Asn Ile Arg Gly Glu Gly Phe Gln Lys Glu Ile 
    50                  55                  60                  


Pro Leu Met Ile Glu Asn Lys Asn Val Gly Thr Leu Thr Val Arg Lys 
65                  70                  75                  80  


Asp Ser Ala Gln Val Val Phe Asn Glu Asn Ile Lys Asn Leu Asp Ser 
                85                  90                  95      


Val Glu Gly Trp Gly Gln Phe Glu Ile Gln Ala Arg Asn Val Thr Asp 
            100                 105                 110         


Thr Gly Glu Glu Asn Thr Gly Pro Phe Thr Val Thr Ser Gly Asp Lys 
        115                 120                 125             


Thr Ala Thr Val Asn Val Thr Lys Pro Ala Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 


Val Phe Tyr Tyr Lys Thr Gly Asp Met Leu Pro Glu Asp Thr Lys His 
145                 150                 155                 160 


Ile Arg Trp Phe Leu Asn Ile Asn Asn Asn Gly Thr Tyr Val Glu Gln 
                165                 170                 175     


Pro Val Lys Ile Ser Asp Glu Ile Gln Ser Gly Gln Arg Leu Asp Pro 
            180                 185                 190         


Ser Thr Phe Glu Ile Asn Gln Ile His Leu Gly Glu Gln Lys Val Tyr 
        195                 200                 205             


Arg Gly Glu Glu Gly Ile Gln Gln Phe Leu Gln Asp Phe Pro Ser Ala 
    210                 215                 220                 


Thr Phe Asn Phe Ser Val Thr Asp Asn Tyr Ile Glu Ile Thr Ile Pro 
225                 230                 235                 240 


Lys Asn Phe Val Asn Leu Arg Lys Ile Met Val Ser Tyr Lys Thr Ile 
                245                 250                 255     


Ile Glu Asn Pro Glu Gln Ile Asn Phe Glu Asn His Ser Glu Ala Trp 
            260                 265                 270         


Phe Lys Glu Phe Asn Lys Pro Ala Val Asp Gly Glu Ser Phe Asn His 
        275                 280                 285             


Thr Val Lys Asn Ile Ser Ala Ser Gly Gly Val Asn Gly Thr Val Arg 
    290                 295                 300                 


Gly Glu Leu Lys Ile Phe Lys Tyr Ile Asn Asp Thr Glu Ile Gly Ile 
305                 310                 315                 320 


Pro Asn Val Thr Phe Glu Leu Arg Arg Ala Asp Glu Gln Pro Ile Gln 
                325                 330                 335     


Gly Gln Ser Ser Ile Leu Leu Thr Ser Asn Glu Gln Gly Glu Ala Ser 
            340                 345                 350         


Ile Lys Gly Leu Gln Val Gly Asp Tyr Val Val Lys Glu Lys Glu Ala 
        355                 360                 365             


Pro Asn Trp Ile Asp Phe Asp Pro Leu Ser Ser Asn Glu Leu Lys Phe 
    370                 375                 380                 


Ser Ile Asn Glu Asn Asp Thr Glu Gly Val Ser Leu Pro Ile Tyr Asn 
385                 390                 395                 400 


Lys Lys Lys Val Thr Asn Ile Thr Ala Thr Lys Ile Trp Asn Gly Gly 
                405                 410                 415     


Thr Thr Pro Arg Pro Ser Ile Tyr Phe Lys Leu Phe Arg Ala Ser Thr 
            420                 425                 430         


Asn Asn Trp Glu Pro Val Pro Asp Ala Glu Thr Lys Arg Leu Asp Asn 
        435                 440                 445             


Gly Ile Thr Ser Val Thr Trp Glu Asp Ile Gln Gln Tyr Asp Asp Ser 
    450                 455                 460                 


Gly Asn Glu Tyr Thr Phe Lys Val Gln Glu Val Asp Gln Asn Gly Asn 
465                 470                 475                 480 


Asp Tyr Val Pro Ser Gly Tyr Gln Lys Ile Glu Asn Gly Leu Val Val 
                485                 490                 495     


Thr Asn Glu Asn Lys 
            500     


