                         SEQUENCE LISTING

<110>  Yale University
 
<120>  CIRCULATING RENALASE AND METHODS OF INCREASING SAME

<130>  YALE-109/01WO	

<150>  US 60/846,762
<151>  2006-09-25

<160>  13    

<170>  PatentIn version 3.2

<210>  1
<211>  1477
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (24)..(1052)

<400>  1
gcggatcgct gctccctctc gcc atg gcg cag gtg ctg atc gtg ggc gcc ggg     53
                          Met Ala Gln Val Leu Ile Val Gly Ala Gly       
                          1               5                   10        

atg aca gga agc ttg tgc gct gcg ctg ctg agg agg cag acg tcc ggt      101
Met Thr Gly Ser Leu Cys Ala Ala Leu Leu Arg Arg Gln Thr Ser Gly         
                15                  20                  25              

ccc ttg tac ctt gct gtg tgg gac aag gct gac gac tca ggg gga aga      149
Pro Leu Tyr Leu Ala Val Trp Asp Lys Ala Asp Asp Ser Gly Gly Arg         
            30                  35                  40                  

atg act aca gcc tgc agt cct cat aat cct cag tgc aca gct gac ttg      197
Met Thr Thr Ala Cys Ser Pro His Asn Pro Gln Cys Thr Ala Asp Leu         
        45                  50                  55                      

ggt gct cag tac atc acc tgc act cct cat tat gcc aaa aaa cac caa      245
Gly Ala Gln Tyr Ile Thr Cys Thr Pro His Tyr Ala Lys Lys His Gln         
    60                  65                  70                          

cgt ttt tat gat gaa ctg tta gcc tat ggc gtt ttg agg cct cta agc      293
Arg Phe Tyr Asp Glu Leu Leu Ala Tyr Gly Val Leu Arg Pro Leu Ser         
75                  80                  85                  90          

tcg cct att gaa gga atg gtg atg aaa gaa gga gac tgt aac ttt gtg      341
Ser Pro Ile Glu Gly Met Val Met Lys Glu Gly Asp Cys Asn Phe Val         
                95                  100                 105             

gca cct caa gga att tct tca att att aag cat tac ttg aaa gaa tca      389
Ala Pro Gln Gly Ile Ser Ser Ile Ile Lys His Tyr Leu Lys Glu Ser         
            110                 115                 120                 

ggt gca gaa gtc tac ttc aga cat cgt gtg aca cag atc aac cta aga      437
Gly Ala Glu Val Tyr Phe Arg His Arg Val Thr Gln Ile Asn Leu Arg         
        125                 130                 135                     

gat gac aaa tgg gaa gta tcc aaa caa aca ggc tcc cct gag cag ttt      485
Asp Asp Lys Trp Glu Val Ser Lys Gln Thr Gly Ser Pro Glu Gln Phe         
    140                 145                 150                         

gat ctt att gtt ctc aca atg cca gtt cct gag att ctg cag ctt caa      533
Asp Leu Ile Val Leu Thr Met Pro Val Pro Glu Ile Leu Gln Leu Gln         
155                 160                 165                 170         

ggt gac atc acc acc tta att agt gaa tgc caa agg cag caa ctg gag      581
Gly Asp Ile Thr Thr Leu Ile Ser Glu Cys Gln Arg Gln Gln Leu Glu         
                175                 180                 185             

gct gtg agc tac tcc tct cga tat gct ctg ggc ctc ttt tat gaa gct      629
Ala Val Ser Tyr Ser Ser Arg Tyr Ala Leu Gly Leu Phe Tyr Glu Ala         
            190                 195                 200                 

ggt acg aag att gat gtc cct tgg gct ggg cag tac atc acc agt aat      677
Gly Thr Lys Ile Asp Val Pro Trp Ala Gly Gln Tyr Ile Thr Ser Asn         
        205                 210                 215                     

ccc tgc ata cgc ttc gtc tcc att gat aat aag aag cgc aat ata gag      725
Pro Cys Ile Arg Phe Val Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu         
    220                 225                 230                         

tca tca gaa att ggg cct tcc ctc gtg att cac acc act gtc cca ttt      773
Ser Ser Glu Ile Gly Pro Ser Leu Val Ile His Thr Thr Val Pro Phe         
235                 240                 245                 250         

gga gtt aca tac ttg gaa cac agc att gag gat gtg caa gag tta gtc      821
Gly Val Thr Tyr Leu Glu His Ser Ile Glu Asp Val Gln Glu Leu Val         
                255                 260                 265             

ttc cag cag ctg gaa aac att ttg ccg ggt ttg cct cag cca att gct      869
Phe Gln Gln Leu Glu Asn Ile Leu Pro Gly Leu Pro Gln Pro Ile Ala         
            270                 275                 280                 

acc aaa tgc caa aaa tgg aga cat tca cag gtt aca aat gct gct gcc      917
Thr Lys Cys Gln Lys Trp Arg His Ser Gln Val Thr Asn Ala Ala Ala         
        285                 290                 295                     

aac tgt cct ggc caa atg act ctg cat cac aaa cct ttc ctt gca tgt      965
Asn Cys Pro Gly Gln Met Thr Leu His His Lys Pro Phe Leu Ala Cys         
    300                 305                 310                         

gga ggg gat gga ttt act cag tcc aac ttt gat ggc tgc atc act tct     1013
Gly Gly Asp Gly Phe Thr Gln Ser Asn Phe Asp Gly Cys Ile Thr Ser         
315                 320                 325                 330         

gcc cta tgt gtt ctg gaa gct tta aag aat tat att tag tgcctatatc      1062
Ala Leu Cys Val Leu Glu Ala Leu Lys Asn Tyr Ile                         
                335                 340                                 

cttattctct atatgtgtat tgggttttta ttttcacaat tttctgttat tgattatttt   1122

gttttctatt ttgctaagaa aaattactgg aaaattgttc ttcacttatt atcatttttc   1182

atgtggagta taaaatcaat tttgtaattt tgatagttac aacccatgct agaatggaaa   1242

ttcctcacac cttgcacctt ccctactttt ctgaattgct atgactactc cttgttggag   1302

gaaaagtggt acttaaaaaa taacaaacga ctctctcaaa aaaattacat taaatcacaa   1362

taacagtttg tatgccaaaa acttgattat ccttatgaaa atttcaattc tgaataaaga   1422

ataatcacat tatcaaagcc ccatcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        1477


<210>  2
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Val Leu Ile Val Gly Ala Gly Met Thr Gly Ser Leu Cys 
1               5                   10                  15      


Ala Ala Leu Leu Arg Arg Gln Thr Ser Gly Pro Leu Tyr Leu Ala Val 
            20                  25                  30          


Trp Asp Lys Ala Asp Asp Ser Gly Gly Arg Met Thr Thr Ala Cys Ser 
        35                  40                  45              


Pro His Asn Pro Gln Cys Thr Ala Asp Leu Gly Ala Gln Tyr Ile Thr 
    50                  55                  60                  


Cys Thr Pro His Tyr Ala Lys Lys His Gln Arg Phe Tyr Asp Glu Leu 
65                  70                  75                  80  


Leu Ala Tyr Gly Val Leu Arg Pro Leu Ser Ser Pro Ile Glu Gly Met 
                85                  90                  95      


Val Met Lys Glu Gly Asp Cys Asn Phe Val Ala Pro Gln Gly Ile Ser 
            100                 105                 110         


Ser Ile Ile Lys His Tyr Leu Lys Glu Ser Gly Ala Glu Val Tyr Phe 
        115                 120                 125             


Arg His Arg Val Thr Gln Ile Asn Leu Arg Asp Asp Lys Trp Glu Val 
    130                 135                 140                 


Ser Lys Gln Thr Gly Ser Pro Glu Gln Phe Asp Leu Ile Val Leu Thr 
145                 150                 155                 160 


Met Pro Val Pro Glu Ile Leu Gln Leu Gln Gly Asp Ile Thr Thr Leu 
                165                 170                 175     


Ile Ser Glu Cys Gln Arg Gln Gln Leu Glu Ala Val Ser Tyr Ser Ser 
            180                 185                 190         


Arg Tyr Ala Leu Gly Leu Phe Tyr Glu Ala Gly Thr Lys Ile Asp Val 
        195                 200                 205             


Pro Trp Ala Gly Gln Tyr Ile Thr Ser Asn Pro Cys Ile Arg Phe Val 
    210                 215                 220                 


Ser Ile Asp Asn Lys Lys Arg Asn Ile Glu Ser Ser Glu Ile Gly Pro 
225                 230                 235                 240 


Ser Leu Val Ile His Thr Thr Val Pro Phe Gly Val Thr Tyr Leu Glu 
                245                 250                 255     


His Ser Ile Glu Asp Val Gln Glu Leu Val Phe Gln Gln Leu Glu Asn 
            260                 265                 270         


Ile Leu Pro Gly Leu Pro Gln Pro Ile Ala Thr Lys Cys Gln Lys Trp 
        275                 280                 285             


Arg His Ser Gln Val Thr Asn Ala Ala Ala Asn Cys Pro Gly Gln Met 
    290                 295                 300                 


Thr Leu His His Lys Pro Phe Leu Ala Cys Gly Gly Asp Gly Phe Thr 
305                 310                 315                 320 


Gln Ser Asn Phe Asp Gly Cys Ile Thr Ser Ala Leu Cys Val Leu Glu 
                325                 330                 335     


Ala Leu Lys Asn Tyr Ile 
            340         


<210>  3
<211>  2107
<212>  DNA
<213>  Homo sapiens

<400>  3
aaaagcccgg gccgaacggc cccgccgcag agactcagcg cggatcgctg ctccctctcg     60

ccatggcgca ggtgctgatc gtgggcgccg ggatgacagg aagcttgtgc gctgcgctgc    120

tgaggaggca gacgtccggt cccttgtacc ttgctgtgtg ggacaaggct gaggactcag    180

ggggaagaat gactacagcc tgcagtcctc ataatcctca gtgcacagct gacttgggtg    240

ctcagtacat cacctgcact cctcattatg ccaaaaaaca ccaacgtttt tatgatgaac    300

tgttagccta tggcgttttg aggcctctaa gctcgcctat tgaaggaatg gtgatgaaag    360

aaggagactg taactttgtg gcacctcaag gaatttcttc aattattaag cattacttga    420

aagaatcagg tgcagaagtc tacttcagac atcgtgtgac acagatcaac ctaagagatg    480

acaaatggga agtatccaaa caaacaggct cccctgagca gtttgatctt attgttctca    540

caatgccagt tcctgagatt ctgcagcttc aaggtgacat caccacctta attagtgaat    600

gccaaaggca gcaactggag gctgtgagct actcctctcg atatgctctg ggcctctttt    660

atgaagctgg tacgaagatt gatgtccctt gggctgggca gtacatcacc agtaatccct    720

gcatacgctt cgtctccatt gataataaga agcgcaatat agagtcatca gaaattgggc    780

cttccctcgt gattcacacc actgtcccat ttggagttac atacttggaa cacagcattg    840

aggatgtgca agagttagtc ttccagcagc tggaaaacat tttgccgggt ttgcctcagc    900

caattgctac caaatgccaa aaatggagac attcacaggt accaagtgct ggtgtgattc    960

taggatgtgc gaagagcccc tggatgatgg cgattggatt tcccatctga cttcctggaa   1020

attggagcac acagtcaggt tttatttgat tttttttttt aaggatacca cttcacagcc   1080

tttaggatag ctattattta gaagcaaaac agaagataaa tgttggcaag gatgtggaga   1140

tattggattc ccttgtgcag tgccggtggg aatgtaaaat gatgtagcta ctatggaaaa   1200

tgatacggca atttctttag aaatgaaata tagaattgcc gtatgatctg cagttccaca   1260

tctggatatc tatccaaaag aagtgaaagt agggacttga acgaacattt gtacaccaat   1320

gttcacagcg gctttattca caacagccaa aaggtggaag caacccagtg tccatggata   1380

gatgaataga taaataaaat gtggtataaa catacaatgg gctattgttt agccttaaaa   1440

gggaaggaaa ttctgacatg ctgcaatatg gatgaagctt aaagtcatta tgcaaagtgg   1500

aataagccta tcacaaaaaa taatattaca taattctact tatatgagga atctagagca   1560

gtcagtttca cagagacaga aaatagaatg gtggttgcca agggctggga gaagagggca   1620

atggagagtg agtgtttagt gggtcagagt tttagtttgg gaaggtaaaa agttctggag   1680

atggatgatg gttatgggtg ctcaacagtg tgaatgtact taatgccaca gaactgcaca   1740

tttaaatgtg gttaaaatca tcacttttat gttatgtata tttaccacaa taaataaaga   1800

agttgatatt tcttatactt acaaagagga gaagggcatt tgcaaatcaa caagaagtgt   1860

gaggcccctc tctctagcag aaaaatagac taaatctatt tctttatctt ttaacatcct   1920

gtttaaggga aatgccaaaa caaatgggaa aaaatacaca cacacaaata tatatgaaca   1980

tgttttgcct catgagtaat caaaatgtgt acatatgtat gtttatgtat gtgtgtttat   2040

atttaaaatc gtgttctgcc ttatgagtaa acaaaaagta tacaaattaa aaactataat   2100

gaaacgt                                                             2107


<210>  4
<211>  2107
<212>  DNA
<213>  Homo sapiens

<400>  4
aaaagcccgg gccgaacggc cccgccgcag agactcagcg cggatcgctg ctccctctcg     60

ccatggcgca ggtgctgatc gtgggcgccg ggatgacagg aagcttgtgc gctgcgctgc    120

tgaggaggca gacgtccggt cccttgtacc ttgctgtgtg ggacaaggct gaggactcag    180

ggggaagaat gactacagcc tgcagtcctc ataatcctca gtgcacagct gacttgggtg    240

ctcagtacat cacctgcact cctcattatg ccaaaaaaca ccaacgtttt tatgatgaac    300

tgttagccta tggcgttttg aggcctctaa gctcgcctat tgaaggaatg gtgatgaaag    360

aaggagactg taactttgtg gcacctcaag gaatttcttc aattattaag cattacttga    420

aagaatcagg tgcagaagtc tacttcagac atcgtgtgac acagatcaac ctaagagatg    480

acaaatggga agtatccaaa caaacaggct cccctgagca gtttgatctt attgttctca    540

caatgccagt tcctgagatt ctgcagcttc aaggtgacat caccacctta attagtgaat    600

gccaaaggca gcaactggag gctgtgagct actcctctcg atatgctctg ggcctctttt    660

atgaagctgg tacgaagatt gatgtccctt gggctgggca gtacatcacc agtaatccct    720

gcatacgctt cgtctccatt gataataaga agcgcaatat agagtcatca gaaattgggc    780

cttccctcgt gattcacacc actgtcccat ttggagttac atacttggaa cacagcattg    840

aggatgtgca agagttagtc ttccagcagc tggaaaacat tttgccgggt ttgcctcagc    900

caattgctac caaatgccaa aaatggagac attcacaggt accaagtgct ggtgtgattc    960

taggatgtgc gaagagcccc tggatgatgg cgattggatt tcccatctga cttcctggaa   1020

attggagcac acagtcaggt tttatttgat tttttttttt aaggatacca cttcacagcc   1080

tttaggatag ctattattta gaagcaaaac agaagataaa tgttggcaag gatgtggaga   1140

tattggattc ccttgtgcag tgccggtggg aatgtaaaat gatgtagcta ctatggaaaa   1200

tgatacggca atttctttag aaatgaaata tagaattgcc gtatgatctg cagttccaca   1260

tctggatatc tatccaaaag aagtgaaagt agggacttga acgaacattt gtacaccaat   1320

gttcacagcg gctttattca caacagccaa aaggtggaag caacccagtg tccatggata   1380

gatgaataga taaataaaat gtggtataaa catacaatgg gctattgttt agccttaaaa   1440

gggaaggaaa ttctgacatg ctgcaatatg gatgaagctt aaagtcatta tgcaaagtgg   1500

aataagccta tcacaaaaaa taatattaca taattctact tatatgagga atctagagca   1560

gtcagtttca cagagacaga aaatagaatg gtggttgcca agggctggga gaagagggca   1620

atggagagtg agtgtttagt gggtcagagt tttagtttgg gaaggtaaaa agttctggag   1680

atggatgatg gttatgggtg ctcaacagtg tgaatgtact taatgccaca gaactgcaca   1740

tttaaatgtg gttaaaatca tcacttttat gttatgtata tttaccacaa taaataaaga   1800

agttgatatt tcttatactt acaaagagga gaagggcatt tgcaaatcaa caagaagtgt   1860

gaggcccctc tctctagcag aaaaatagac taaatctatt tctttatctt ttaacatcct   1920

gtttaaggga aatgccaaaa caaatgggaa aaaatacaca cacacaaata tatatgaaca   1980

tgttttgcct catgagtaat caaaatgtgt acatatgtat gtttatgtat gtgtgtttat   2040

atttaaaatc gtgttctgcc ttatgagtaa acaaaaagta tacaaattaa aaactataat   2100

gaaacgt                                                             2107


<210>  5
<211>  1924
<212>  DNA
<213>  Homo sapiens

<400>  5
ggggaagtct tgtgagatct gatggttttg taaagggcag ttgtacatat gctatcttgc     60

ctgccaccac taattagtga atgccaaagg cagcaactgg aggccgtgag ctactcctct    120

cgatatgctc tgggcctctt ttatgaagct ggtacgaaga ttgatgtccc ttgggctggg    180

cagtacatca ccagtaatcc ctgcatacgc ttcgtctcca ttgataataa gaagcgcaat    240

atagagtcat cagaaattgg gccttccctc gtgattcaca ccactgtccc atttggagtt    300

acatacttgg aacacagcat tgaggatgtg caagagttag tcttccagca gctggaaaac    360

attttgccgg gtttgcctca gccaattgct accaaatgcc aaaaatggag acattcacag    420

attttgtttg gtgggggaag tggatgtgca cacagaagag cttgagacca cccgtacgtt    480

tacattatcc cctcatgaga ttaatttctg gttacaaatg ctgctgccaa ctgtcctggc    540

caaatgactc tgcatcacaa acctttcctt gcatgtggag gggatggatt tactcagtcc    600

aactttgatg gctgcatcac ttctgcccta tgtgttctgg aagctttaaa gaattatatt    660

tagtgcctat atccttattc tctacatgtg tattgggttt ttattttcac aattttctgt    720

tattgattat tttgttttct attttgctaa gaaaaattac tggaaaattg ttcttcactt    780

attatcattt ttcatgtgga gtataaaatc aattttgtaa ttttgatagt tacaacccat    840

gctagaatgg aaattcctca caccttgcac cttccctact tttctgaatt gctatgacta    900

ctccttgttg aaggaaaagt ggtacttaaa aaataacaaa cgactctctc aaaaaaatta    960

cattaaatca caataacagt ttgtatgcca aaaacttgat tatccttatg aaaatttcaa   1020

ttctgaataa agaataatca cattatcaaa gccccatctt aagtcttcgg atgtgtcctt   1080

gaatcaataa ttttgcaaat tatacaaaac aagatttttc caaaatgtag gtaacagagt   1140

gtaattctta tttctcattt atcccccaag ttattaagtg atcctgaatt gtaggtcata   1200

tatgtcatca tcttagtgtg gagggcaact tgactgataa agagaccttc cttcagattt   1260

tcagaaagta taagattcca catgattttc ccagccacac agtacttttt aactttcaaa   1320

caaattccag tcctaatatg aaagataaaa attaaataga aacagagaga aagtatatcg   1380

atccttacct tttgctatat tttatagctg ttgctgttac tttatgggct ctccagtatg   1440

tgctgtggca tttagactgt gtcgagttta atgaatttaa cacaacaaaa aatttactga   1500

accagaaaat agatgcactt aaaatagttc aatatttgcc aagttggtgg ttcagcatat   1560

cacccacatg cttcagtgac ctgaccccac gacttgctag ctggagagaa atcaatctcc   1620

agccttccaa accagctacc tgttgctaat ttgaaaagca aaatgatgag ttctatttca   1680

gcattttgaa aggagaaaaa tcattgcagc ctctcaaact aacaaaagtt caacaaaaga   1740

cttcttactg taatagtgtt taaagtttca cacttacatg tccactgtca tacatacaca   1800

tacacaggca caggcagaac ttgcttctat agctgcaaag tgggttttat gaccctatag   1860

catattatta tatgtttcct cttagcaata aattggtgaa aaacttaaat gccaaaaaaa   1920

aaaa                                                                1924


<210>  6
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
tgcaggcacc gtcgtcgact taacaatgcg accccagggc cccgccg                   47


<210>  7
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
catcaatgta tcttatcatg tctgatcaac cagctaccca tacgatgttc cagattacgc     60

tttttggtag ttcttcaata ag                                              82


<210>  8
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
ttttggatcc atggcgcagg tgctgatcgt g                                    31


<210>  9
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
ttttgaattc ctaaatataa ttctttaaag c                                    31


<210>  10
<211>  4090
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (182)..(1765)

<400>  10
gggcgctccc ggagtatcag caaaagggtt cgccccgccc acagtgcccg gctccccccg     60

ggtatcaaaa gaaggatcgg ctccgccccc gggctccccg ggggagttga tagaagggtc    120

cttcccaccc tttgccgtcc ccactcctgt gcctacgacc caggagcgtg tcagccaaag    180

c atg gag aat caa gag aag gcg agt atc gcg ggc cac atg ttc gac gta    229
  Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val       
  1               5                   10                  15            

gtc gtg atc gga ggt ggc att tca gga cta tct gct gcc aaa ctc ttg      277
Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu         
            20                  25                  30                  

act gaa tat ggc gtt agt gtt ttg gtt tta gaa gct cgg gac agg gtt      325
Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val         
        35                  40                  45                      

gga gga aga aca tat act ata agg aat gag cat gtt gat tac gta gat      373
Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp         
    50                  55                  60                          

gtt ggt gga gct tat gtg gga cca acc caa aac aga atc tta cgc ttg      421
Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu         
65                  70                  75                  80          

tct aag gag ctg ggc ata gag act tac aaa gtg aat gtc agt gag cgt      469
Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg         
                85                  90                  95              

ctc gtt caa tat gtc aag ggg aaa aca tat cca ttt cgg ggc gcc ttt      517
Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe         
            100                 105                 110                 

cca cca gta tgg aat ccc att gca tat ttg gat tac aat aat ctg tgg      565
Pro Pro Val Trp Asn Pro Ile Ala Tyr Leu Asp Tyr Asn Asn Leu Trp         
        115                 120                 125                     

agg aca ata gat aac atg ggg aag gag att cca act gat gca ccc tgg      613
Arg Thr Ile Asp Asn Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp         
    130                 135                 140                         

gag gct caa cat gct gac aaa tgg gac aaa atg acc atg aaa gag ctc      661
Glu Ala Gln His Ala Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu         
145                 150                 155                 160         

att gac aaa atc tgc tgg aca aag act gct agg cgg ttt gct tat ctt      709
Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu         
                165                 170                 175             

ttt gtg aat atc aat gtg acc tct gag cct cac gaa gtg tct gcc ctg      757
Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu         
            180                 185                 190                 

tgg ttc ttg tgg tat gtg aag cag tgc ggg ggc acc act cgg ata ttc      805
Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe         
        195                 200                 205                     

tct gtc acc aat ggt ggc cag gaa cgg aag ttt gta ggt gga tct ggt      853
Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly         
    210                 215                 220                         

caa gtg agc gaa cgg ata atg gac ctc ctc gga gac caa gtg aag ctg      901
Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu         
225                 230                 235                 240         

aac cat cct gtc act cac gtt gac cag tca agt gac aac atc atc ata      949
Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile         
                245                 250                 255             

gag acg ctg aac cat gaa cat tat gag tgc aaa tac gta att aat gcg      997
Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala         
            260                 265                 270                 

atc cct ccg acc ttg act gcc aag att cac ttc aga cca gag ctt cca     1045
Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro         
        275                 280                 285                     

gca gag aga aac cag tta att cag cgg ctt cca atg gga gct gtc att     1093
Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile         
    290                 295                 300                         

aag tgc atg atg tat tac aag gag gcc ttc tgg aag aag aag gat tac     1141
Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr         
305                 310                 315                 320         

tgt ggc tgc atg atc att gaa gat gaa gat gct cca att tca ata acc     1189
Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr         
                325                 330                 335             

ttg gat gac acc aag cca gat ggg tca ctg cct gcc atc atg ggc ttc     1237
Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe         
            340                 345                 350                 

att ctt gcc cgg aaa gct gat cga ctt gct aag cta cat aag gaa ata     1285
Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile         
        355                 360                 365                     

agg aag aag aaa atc tgt gag ctc tat gcc aaa gtg ctg gga tcc caa     1333
Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln         
    370                 375                 380                         

gaa gct tta cat cca gtg cat tat gaa gag aag aac tgg tgt gag gag     1381
Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu         
385                 390                 395                 400         

cag tac tct ggg ggc tgc tac acg gcc tac ttc cct cct ggg atc atg     1429
Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met         
                405                 410                 415             

act caa tat gga agg gtg att cgt caa ccc gtg ggc agg att ttc ttt     1477
Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe         
            420                 425                 430                 

gcg ggc aca gag act gcc aca aag tgg agc ggc tac atg gaa ggg gca     1525
Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala         
        435                 440                 445                     

gtt gag gct gga gaa cga gca gct agg gag gtc tta aat ggt ctc ggg     1573
Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly         
    450                 455                 460                         

aag gtg acc gag aaa gat atc tgg gta caa gaa cct gaa tca aag gac     1621
Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp         
465                 470                 475                 480         

gtt cca gcg gta gaa atc acc cac acc ttc tgg gaa agg aac ctg ccc     1669
Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro         
                485                 490                 495             

tct gtt tct ggc ctg ctg aag atc att gga ttt tcc aca tca gta act     1717
Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr         
            500                 505                 510                 

gcc ctg ggg ttt gtg ctg tac aaa tac aag ctc ctg cca cgg tct tga     1765
Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser             
        515                 520                 525                     

agttctgttc ttatgctctc tgctcactgg ttttcaatac caccaagagg aaaatattga   1825

caagtttaaa ggctgtgtca ttgggccatg tttaagtgta ctggatttaa ctacctttgg   1885

cttaattcca atcattgtta aagtaaaaac aattcaaaga atcacctaat taatttcagt   1945

aagatcaagc tccatcttat ttgtcagtgt agatcaactc atgttaattg atagaataaa   2005

gccttgtgat cactttctga aattcacaaa gttaaacgtg atgtgctcat cagaaacaat   2065

ttctgtgtcc tgtttttatt cccttcaatg caaaatacat gatgatttca gaaacaaagc   2125

atttgacttt ctgtctgtgg aggtggagta ggtgaaggcc cagcctgtaa ctgtcctttt   2185

tcttccctta ggcaatggtg aactgtcatt acagagccta gaggctcaca gcctcctgga   2245

ggaagcagcc tccactttgg atcaggaaat agtaaaggaa agcagtgttg ggggtagcgg   2305

catgcagacc ctcagaccag aatggggaca tcttgtggtc tgctgcctca ggaatctcct   2365

gaccacttgt agtccctccg acttctctag acatctagtc tcagtgctag cttatttgta   2425

tttttcctct ttcacttctt atggaggaga gtgtttaact gagttagaat gttgaaactg   2485

acttgctgtg acttatgtgc agctttccag ttgagcagag gaaaatagtg gcaggactgt   2545

cccccaggag gactccctgc ttagctctgt gggagaccaa ctacgactgg catcttctct   2605

tccccctgga aggcagctag acaccaatgg atccttgtca gttgtaacat tctatttcaa   2665

cttcaggaaa gcagcagttt tcttttaatt tttcctatga ccataaaatt agacatacct   2725

ctcaacttac atatgtcttc aacatggtta cctctgcata aatattagca aagcatgcca   2785

atttctctta agtactgaaa tacatatgat aaatttgact gttatttgtt gagactatca   2845

aacagaaaag aaattagggc tctaatttcc ttaaagcaag ctcacttgct ttagttgtta   2905

agttttataa aagacatgaa attgagtcat tttatatatg aaaactaagt tctctatctt   2965

aggagtaatg tcggcccaca agggtgccca cctcttgttt tcccctttta aaaactcaga   3025

tttttaaaag ccctttccaa aggtttcaac tgtaaaatac ttctttttac aatgtatcaa   3085

catattttta tttaagggga attaacaatt gccagggaaa ccagccaacc caagtttatt   3145

atatcattaa ccttatcata aattcaaacc taagttgctg gaccctggtg tgaggacata   3205

aatcttccaa agttttgcct atcctaagag ctgcattttt ctactgctct ttaccttgca   3265

ttttagctaa tttaggagtt ttgagaatgt attggatacg ctccagtaca taaggagttg   3325

ccgcatatta tatcagactg ctttgagaaa tctcatccct agtctattgc agttgtttct   3385

attagcttac tgattaactc agtcctgaca caccttttgg gaaatgctga tttaaacttc   3445

ttaactggca acagttggaa cagtaatcag tttgctaaca tatttaaagt cttgaatgtt   3505

gaagaactca tgtgatttac ccttttcaac tttttggaaa acgatttaat ttattctaat   3565

tagattaacc ctattaatct atggattggg tatcaaaatg aatgccagtc cagatgtgcc   3625

tagacacgaa attggagctg aggactctca cgatatgcaa gttcatccaa cgtgaagata   3685

ccataagctt tttctctgaa ccagagaaat gaaagtcagt ttaagaggct gatagatctt   3745

ggccctgtta aggcatccac ttcacagttc tgaaggctga gtcagcccca ctccacagtt   3805

aggccaagaa ttagatttta aaacttcatc tgtctgtccc agttaactgt taaataaggc   3865

ctcatcctcc actgaagagt atggattgaa ggattgtgaa ctatgtttag tgtgattgtg   3925

aacttggtgc ctaatgttcc atgtctgaag tttgccccag tgctacacgt tggagtatac   3985

ctatgtgtgt gctttgccac tgaagtaaga ttttgcctgt atggtactgt tttgtttgtt   4045

aataaagtgc actgccaccc ccaatgcaaa aaaaaaaaaa aaaaa                   4090


<210>  11
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val 
1               5                   10                  15      


Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu 
            20                  25                  30          


Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val 
        35                  40                  45              


Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp 
    50                  55                  60                  


Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu 
65                  70                  75                  80  


Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg 
                85                  90                  95      


Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe 
            100                 105                 110         


Pro Pro Val Trp Asn Pro Ile Ala Tyr Leu Asp Tyr Asn Asn Leu Trp 
        115                 120                 125             


Arg Thr Ile Asp Asn Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp 
    130                 135                 140                 


Glu Ala Gln His Ala Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu 
145                 150                 155                 160 


Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu 
                165                 170                 175     


Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu 
            180                 185                 190         


Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe 
        195                 200                 205             


Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly 
    210                 215                 220                 


Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu 
225                 230                 235                 240 


Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile 
                245                 250                 255     


Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala 
            260                 265                 270         


Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro 
        275                 280                 285             


Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile 
    290                 295                 300                 


Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr 
305                 310                 315                 320 


Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr 
                325                 330                 335     


Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe 
            340                 345                 350         


Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile 
        355                 360                 365             


Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln 
    370                 375                 380                 


Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu 
385                 390                 395                 400 


Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met 
                405                 410                 415     


Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe 
            420                 425                 430         


Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala 
        435                 440                 445             


Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly 
    450                 455                 460                 


Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp 
465                 470                 475                 480 


Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro 
                485                 490                 495     


Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr 
            500                 505                 510         


Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser 
        515                 520                 525         


<210>  12
<211>  2566
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (137)..(1699)

<400>  12
cgaggcgctg gtgcacgggg gcagcgcgca gcaggccggc gggcaggcgg gcgggctggc     60

tggcaggcag gactgggatc gaggcccaga aaacggagca gcgggcacca gggaggcctg    120

gaacggggcg agcgcc atg agc aac aaa tgc gac gtg gtc gtg gtg ggg ggc    172
                  Met Ser Asn Lys Cys Asp Val Val Val Val Gly Gly       
                  1               5                   10                

ggc atc tca ggt atg gca gca gcc aaa ctt ctg cat gac tct gga ctg      220
Gly Ile Ser Gly Met Ala Ala Ala Lys Leu Leu His Asp Ser Gly Leu         
        15                  20                  25                      

aat gtg gtt gtt ctg gaa gcc cgg gac cgt gtg gga ggc agg act tac      268
Asn Val Val Val Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Thr Tyr         
    30                  35                  40                          

act ctt agg aac caa aag gtt aaa tat gtg gac ctt gga gga tcc tat      316
Thr Leu Arg Asn Gln Lys Val Lys Tyr Val Asp Leu Gly Gly Ser Tyr         
45                  50                  55                  60          

gtt gga cca acc cag aat cgt atc ttg aga tta gcc aag gag cta gga      364
Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu Ala Lys Glu Leu Gly         
                65                  70                  75              

ttg gag acc tac aaa gtg aat gag gtt gag cgt ctg atc cac cat gta      412
Leu Glu Thr Tyr Lys Val Asn Glu Val Glu Arg Leu Ile His His Val         
            80                  85                  90                  

aag ggc aaa tca tac ccc ttc agg ggg cca ttc cca cct gta tgg aat      460
Lys Gly Lys Ser Tyr Pro Phe Arg Gly Pro Phe Pro Pro Val Trp Asn         
        95                  100                 105                     

cca att acc tac tta gat cat aac aac ttt tgg agg aca atg gat gac      508
Pro Ile Thr Tyr Leu Asp His Asn Asn Phe Trp Arg Thr Met Asp Asp         
    110                 115                 120                         

atg ggg cga gag att ccg agt gat gcc cca tgg aag gct ccc ctt gca      556
Met Gly Arg Glu Ile Pro Ser Asp Ala Pro Trp Lys Ala Pro Leu Ala         
125                 130                 135                 140         

gaa gag tgg gac aac atg aca atg aag gag cta ctg gac aag ctc tgc      604
Glu Glu Trp Asp Asn Met Thr Met Lys Glu Leu Leu Asp Lys Leu Cys         
                145                 150                 155             

tgg act gaa tct gca aag cag ctt gcc act ctc ttt gtg aac ctg tgt      652
Trp Thr Glu Ser Ala Lys Gln Leu Ala Thr Leu Phe Val Asn Leu Cys         
            160                 165                 170                 

gtc act gca gag acc cat gag gtc tct gct ctc tgg ttc ctg tgg tat      700
Val Thr Ala Glu Thr His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr         
        175                 180                 185                     

gtg aag cag tgt gga ggc aca aca aga atc atc tcg aca aca aat gga      748
Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Ile Ser Thr Thr Asn Gly         
    190                 195                 200                         

gga cag gag agg aaa ttt gtg ggc gga tct ggt caa gtg agt gag cgg      796
Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg         
205                 210                 215                 220         

ata atg gac ctc ctt gga gac cga gtg aag ctg gag agg cct gtg atc      844
Ile Met Asp Leu Leu Gly Asp Arg Val Lys Leu Glu Arg Pro Val Ile         
                225                 230                 235             

tac att gac cag aca aga gaa aat gtc ctt gtg gag acc cta aac cat      892
Tyr Ile Asp Gln Thr Arg Glu Asn Val Leu Val Glu Thr Leu Asn His         
            240                 245                 250                 

gag atg tat gag gct aaa tat gtg att agt gct att cct cct act ctg      940
Glu Met Tyr Glu Ala Lys Tyr Val Ile Ser Ala Ile Pro Pro Thr Leu         
        255                 260                 265                     

ggc atg aag att cac ttc aat ccc cct ctg cca atg atg aga aac cag      988
Gly Met Lys Ile His Phe Asn Pro Pro Leu Pro Met Met Arg Asn Gln         
    270                 275                 280                         

atg atc act cgt gtg cct ttg ggt tca gtc atc aag tgt ata gtt tat     1036
Met Ile Thr Arg Val Pro Leu Gly Ser Val Ile Lys Cys Ile Val Tyr         
285                 290                 295                 300         

tat aaa gag cct ttc tgg agg aaa aag gat tac tgt gga acc atg att     1084
Tyr Lys Glu Pro Phe Trp Arg Lys Lys Asp Tyr Cys Gly Thr Met Ile         
                305                 310                 315             

att gat gga gaa gaa gct cca gtt gcc tac acg ttg gat gat acc aaa     1132
Ile Asp Gly Glu Glu Ala Pro Val Ala Tyr Thr Leu Asp Asp Thr Lys         
            320                 325                 330                 

cct gaa ggc aac tat gct gcc ata atg gga ttt atc ctg gcc cac aaa     1180
Pro Glu Gly Asn Tyr Ala Ala Ile Met Gly Phe Ile Leu Ala His Lys         
        335                 340                 345                     

gcc aga aaa ctg gca cgt ctt acc aaa gag gaa agg ttg aag aaa ctt     1228
Ala Arg Lys Leu Ala Arg Leu Thr Lys Glu Glu Arg Leu Lys Lys Leu         
    350                 355                 360                         

tgt gaa ctc tat gcc aag gtt ctg ggt tcc cta gaa gct ctg gag cca     1276
Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Leu Glu Ala Leu Glu Pro         
365                 370                 375                 380         

gtg cat tat gaa gaa aag aac tgg tgt gag gag cag tac tct ggg ggc     1324
Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly         
                385                 390                 395             

tgc tac aca act tat ttc ccc cct ggg atc ctg act caa tat gga agg     1372
Cys Tyr Thr Thr Tyr Phe Pro Pro Gly Ile Leu Thr Gln Tyr Gly Arg         
            400                 405                 410                 

gtt cta cgc cag cca gtg gac agg att tac ttt gca ggc acc gag act     1420
Val Leu Arg Gln Pro Val Asp Arg Ile Tyr Phe Ala Gly Thr Glu Thr         
        415                 420                 425                     

gcc aca cac tgg agc ggc tac atg gag ggg gct gta gag gcc ggg gag     1468
Ala Thr His Trp Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu         
    430                 435                 440                         

aga gca gcc cga gag atc ctg cat gcc atg ggg aag att cca gag gat     1516
Arg Ala Ala Arg Glu Ile Leu His Ala Met Gly Lys Ile Pro Glu Asp         
445                 450                 455                 460         

gaa atc tgg cag tca gaa cca gag tct gtg gat gtc cct gca cag ccc     1564
Glu Ile Trp Gln Ser Glu Pro Glu Ser Val Asp Val Pro Ala Gln Pro         
                465                 470                 475             

atc acc acc acc ttt ttg gag aga cat ttg ccc tcc gtg cca ggc ctg     1612
Ile Thr Thr Thr Phe Leu Glu Arg His Leu Pro Ser Val Pro Gly Leu         
            480                 485                 490                 

ctc agg ctg att gga ttg acc acc atc ttt tca gca acg gct ctt ggc     1660
Leu Arg Leu Ile Gly Leu Thr Thr Ile Phe Ser Ala Thr Ala Leu Gly         
        495                 500                 505                     

ttc ctg gcc cac aaa agg ggg cta ctt gtg aga gtc taa agagagaggg      1709
Phe Leu Ala His Lys Arg Gly Leu Leu Val Arg Val                         
    510                 515                 520                         

tgtctgtaat cacactctct tcttactgta tttgggatat gagtttgggg aaagagttgc   1769

agtaaagttc catgaagaca aatagtgtgg agtgaggcgg ggagcatgaa gataaatcca   1829

actctgactg taaaatacat ggtatctctt tctccgttgt ggcccctgct tagtgtccct   1889

tacctggctt agcgttctgt ttcaccagtt tccaagttta ttgccctcaa aatctttaga   1949

atagttaaat tggcttgttt aaggttcttg ctgccccaca acacaccttg cccatgcaca   2009

aggaatgaat tttttcctac cattatggct ttgtgcttgt tcttcctctt acctgtaata   2069

gcctcacctt ccctagttct ttgcattcgt ccttagaata ctgtattgtt acagctgaaa   2129

gacagtaaag accatttagt cctcaccttc tgttttagag ttgagcaaac tgaagcccac   2189

agaggtggaa cttaattacc taagagccac aataagccac tggtatctgg gggactagaa   2249

cacaaatcca acgcttttcc cacctctttg gatgttttcc ccaattatcc tccttcactc   2309

cctgtcatag ttaccgatgg tgtcccgttg tgtgggttta ctctgtgcta agttgtctta   2369

cacttctcaa atgctactca gtatatagcc ttaagtctta ctgttttgtg cggtgtgtct   2429

ccagctgatt ttaacttttt tgatggtaga aattttatct cttcttcctt ttgtatcctc   2489

cattgtatct tcatacaaag gacagtacac acttgggtaa ttaaaaataa aagttgattg   2549

accataaaaa aaaaaaa                                                  2566


<210>  13
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Asn Lys Cys Asp Val Val Val Val Gly Gly Gly Ile Ser Gly 
1               5                   10                  15      


Met Ala Ala Ala Lys Leu Leu His Asp Ser Gly Leu Asn Val Val Val 
            20                  25                  30          


Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Thr Tyr Thr Leu Arg Asn 
        35                  40                  45              


Gln Lys Val Lys Tyr Val Asp Leu Gly Gly Ser Tyr Val Gly Pro Thr 
    50                  55                  60                  


Gln Asn Arg Ile Leu Arg Leu Ala Lys Glu Leu Gly Leu Glu Thr Tyr 
65                  70                  75                  80  


Lys Val Asn Glu Val Glu Arg Leu Ile His His Val Lys Gly Lys Ser 
                85                  90                  95      


Tyr Pro Phe Arg Gly Pro Phe Pro Pro Val Trp Asn Pro Ile Thr Tyr 
            100                 105                 110         


Leu Asp His Asn Asn Phe Trp Arg Thr Met Asp Asp Met Gly Arg Glu 
        115                 120                 125             


Ile Pro Ser Asp Ala Pro Trp Lys Ala Pro Leu Ala Glu Glu Trp Asp 
    130                 135                 140                 


Asn Met Thr Met Lys Glu Leu Leu Asp Lys Leu Cys Trp Thr Glu Ser 
145                 150                 155                 160 


Ala Lys Gln Leu Ala Thr Leu Phe Val Asn Leu Cys Val Thr Ala Glu 
                165                 170                 175     


Thr His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr Val Lys Gln Cys 
            180                 185                 190         


Gly Gly Thr Thr Arg Ile Ile Ser Thr Thr Asn Gly Gly Gln Glu Arg 
        195                 200                 205             


Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg Ile Met Asp Leu 
    210                 215                 220                 


Leu Gly Asp Arg Val Lys Leu Glu Arg Pro Val Ile Tyr Ile Asp Gln 
225                 230                 235                 240 


Thr Arg Glu Asn Val Leu Val Glu Thr Leu Asn His Glu Met Tyr Glu 
                245                 250                 255     


Ala Lys Tyr Val Ile Ser Ala Ile Pro Pro Thr Leu Gly Met Lys Ile 
            260                 265                 270         


His Phe Asn Pro Pro Leu Pro Met Met Arg Asn Gln Met Ile Thr Arg 
        275                 280                 285             


Val Pro Leu Gly Ser Val Ile Lys Cys Ile Val Tyr Tyr Lys Glu Pro 
    290                 295                 300                 


Phe Trp Arg Lys Lys Asp Tyr Cys Gly Thr Met Ile Ile Asp Gly Glu 
305                 310                 315                 320 


Glu Ala Pro Val Ala Tyr Thr Leu Asp Asp Thr Lys Pro Glu Gly Asn 
                325                 330                 335     


Tyr Ala Ala Ile Met Gly Phe Ile Leu Ala His Lys Ala Arg Lys Leu 
            340                 345                 350         


Ala Arg Leu Thr Lys Glu Glu Arg Leu Lys Lys Leu Cys Glu Leu Tyr 
        355                 360                 365             


Ala Lys Val Leu Gly Ser Leu Glu Ala Leu Glu Pro Val His Tyr Glu 
    370                 375                 380                 


Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly Cys Tyr Thr Thr 
385                 390                 395                 400 


Tyr Phe Pro Pro Gly Ile Leu Thr Gln Tyr Gly Arg Val Leu Arg Gln 
                405                 410                 415     


Pro Val Asp Arg Ile Tyr Phe Ala Gly Thr Glu Thr Ala Thr His Trp 
            420                 425                 430         


Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu Arg Ala Ala Arg 
        435                 440                 445             


Glu Ile Leu His Ala Met Gly Lys Ile Pro Glu Asp Glu Ile Trp Gln 
    450                 455                 460                 


Ser Glu Pro Glu Ser Val Asp Val Pro Ala Gln Pro Ile Thr Thr Thr 
465                 470                 475                 480 


Phe Leu Glu Arg His Leu Pro Ser Val Pro Gly Leu Leu Arg Leu Ile 
                485                 490                 495     


Gly Leu Thr Thr Ile Phe Ser Ala Thr Ala Leu Gly Phe Leu Ala His 
            500                 505                 510         


Lys Arg Gly Leu Leu Val Arg Val 
        515                 520 


