                         SEQUENCE LISTING

<110>  CEDARS-SINAI MEDICAL CENTER
       Rappaport, Basil
       McLachlan, Sandra
       Chen, Chun-Rong
 
<120>  MONOCLONAL ANTIBODY THAT SUPPRESSES THYROTROPIN RECEPTOR 
       CONSTITUTIVE ACTIVITY

<130>  67789-972

<150>  60/886,564
<151>  2007-01-25

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys His Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Asp Met Arg Gln Gly Leu His Asn Met Glu 
                725                 730                 735     


Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Met Gln Thr Val Leu 
        755                 760                 


<210>  2
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Phe Gln Gly Leu Cys Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn 
1               5                   10                  15      


Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu 
            20                  25                  30          


Asp Ala Val Tyr Leu Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys 
        35                  40                  45              


Asp Ala Phe Gly Gly Val Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser 
    50                  55                  60                  


Gln Thr Ser Val Thr Ala Leu Pro Ser Lys Gly Leu Glu His Leu Lys 
65                  70                  75                  80  


Glu Leu Ile Ala Arg Asn Thr Trp Thr Leu 
                85                  90  


<210>  3
<211>  2295
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc     60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc    120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt    180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga    240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg    300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat    360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg    420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac    480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg    540

acactgaagc tgtacaacaa tggctttact tcagtccaag gatatgcttt caatgggaca    600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca    660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc    720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt    780

aagaaacttc cactttcctt gagtttcctt cacctcacac gggctgacct ttcttaccca    840

agccactgct gtgcttttaa gaatcagaag aaaatcagag gaatccttga gtccttgatg    900

tgtaatgaga gcagtatgca gagcttgcgc cagagaaaat ctgtgaatgc cttgaatagc    960

cccctccacc aggaatatga agagaatctg ggtgacagca ttgttgggta caaggaaaag   1020

tccaagttcc aggatactca taacaacgct cattattacg tcttctttga agaacaagag   1080

gatgagatca ttggttttgg ccaggagctc aaaaaccccc aggaagagac tctacaagct   1140

tttgacagcc attatgacta caccatatgt ggggacagtg aagacatggt gtgtaccccc   1200

aagtccgatg agttcaaccc gtgtgaagac ataatgggct acaagttcct gagaattgtg   1260

gtgtggttcg ttagtctgct ggctctcctg ggcaatgtct ttgtcctgct tattctcctc   1320

accagccact acaaactgaa cgtcccccgc tttctcatgt gcaacctggc ctttgcggat   1380

ttctgcatgg ggatgtacct gctcctcatc gcctctgtag acctctacac tcactctgag   1440

tactacaacc atgccatcga ctggcagaca ggccctgggt gcaacacggc tggtttcttc   1500

actgtctttg caagcgagtt atcggtgtat acgctgacgg tcatcaccct ggagcgctgg   1560

tatgccatca ccttcgccat gcgcctggac cggaagatcc gcctcaggca cgcatgtgcc   1620

atcatggttg ggggctgggt ttgctgcttc cttctcgccc tgcttccttt ggtgggaata   1680

agtagctatg ccaaagtcag tatctgcctg cccatggaca ccgagacccc tcttgctctg   1740

gcatatattg tttttgttct gacgctcaac atagttgcct tcgtcatcgt ctgctgctgt   1800

tatgtgaaga tctacatcac agtccgaaat ccgcagtaca acccagggga caaagatacc   1860

aaaattgcca agaggatggc tgtgttgatc ttcaccgact tcatatgcat ggccccaatc   1920

tcattctatg ctctgtcagc aattctgaac aagcctctca tcactgttag caactccaaa   1980

atcttgctgg tactcttcta tccacttaac tcctgtgcca atccattcct ctatgctatt   2040

ttcaccaagg ccttccagag ggatgtgttc atcctactca gcaagtttgg catctgtaaa   2100

cgccaggctc aggcataccg ggggcagagg gttcctccaa agaacagcac tgatattcag   2160

gttcaaaagg ttacccacga catgaggcag ggtctccaca acatggaaga tgtctatgaa   2220

ctgattgaaa actcccatct aaccccaaag aagcaaggcc aaatctcaga agagtatatg   2280

caaacggttt tgtaa                                                    2295


<210>  4
<211>  251
<212>  DNA
<213>  Homo sapiens

<400>  4
gcttttcagg gactatgcaa tgaaaccttg acactgaagc tgtacaacaa tggctttact     60

tcagtccaag gatatgcttt caatgggaca aagctggatg ctgtttacct aaacaagaat    120

aaatacctga cagttattga caaagatgca tttggaggag tatacagtgg accaagcttg    180

ctggacgtgt ctcaaaccag tgtcactgcc cttccatcca aaggcctgga gcacctgaag    240

gaactgatag c                                                         251


