                         SEQUENCE LISTING

<110>  MOCHLY-ROSEN, Daria D.
       QI, Xin
       INAGAKI, Koichi
 
<120>  Methods for maintaining blood-brain barrier integrity in 
       hypertensive subjects using a delta-PKC inhibitor

<130>  586008245WO0

<140>  Not Yet Assigned
<141>  2008-02-05

<150>  US 60/899,917
<151>  2007-02-06

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-V1-1, having a portion of the amino acid sequence of rat 
       delta-PKC

<400>  1

Ser Phe Asn Ser Tyr Glu Leu Gly Ser Leu 
1               5                   10  


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-PKC from rat, amino acids 35 to 45 as found in Genbank 
       Accession No. AAH76505

<400>  2

Ala Leu Thr Thr Asp Arg Gly Lys Thr Leu Val 
1               5                   10      


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-PKC from rat, amino acids 101 to 114 as found in Genbank 
       Accession No. AAH76505

<400>  3

Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  4
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Pro Phe Arg Pro Lys Val Lys Ser Pro Arg Pro Tyr Ser Asn Phe Asp 
1               5                   10                  15      


Gln Glu Phe Leu Asn Glu Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn 
            20                  25                  30          


Leu Ile Asp Ser Met Asp Gln Ser Ala Phe Ala Gly Phe Ser Phe Val 
        35                  40                  45              


Asn Pro Lys Phe Glu His Leu Leu Glu Asp 
    50                  55              


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Thr Phe Asn Ser Tyr Glu Leu Gly Ser Leu 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Ala Phe Asn Ser Tyr Glu Leu Gly Ser Leu 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Ser Phe Asn Ser Tyr Glu Leu Gly Thr Leu 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Thr Phe Asn Ser Tyr Glu Leu Gly Thr Leu 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Ser Tyr Asn Ser Tyr Glu Leu Gly Ser Leu 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Ser Phe Asn Ser Phe Glu Leu Gly Ser Leu 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Ser Asn Ser Tyr Asp Leu Gly Ser Leu 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Ser Phe Asn Ser Tyr Glu Leu Pro Ser Leu 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Ser Phe Asn Ser Tyr Glu Ile Gly Ser Val 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Ser Phe Asn Ser Tyr Glu Val Gly Ser Ile 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Ser Phe Asn Ser Tyr Glu Leu Gly Ser Val 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  16

Ser Phe Asn Ser Tyr Glu Leu Gly Ser Ile 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  17

Ser Phe Asn Ser Tyr Glu Ile Gly Ser Leu 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  18

Ser Phe Asn Ser Tyr Glu Val Gly Ser Leu 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  19

Ala Phe Asn Ser Tyr Glu Leu Gly Ser Leu 
1               5                   10  


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  20

Tyr Glu Leu Gly Ser Leu 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  21

Tyr Asp Leu Gly Ser Leu 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  22

Phe Asp Leu Gly Ser Leu 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  23

Tyr Asp Ile Gly Ser Leu 
1               5       


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  24

Ile Gly Ser Leu 
1               


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  25

Tyr Asp Val Gly Ser Leu 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  26

Tyr Asp Leu Pro Ser Leu 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  27

Tyr Asp Leu Gly Ile Leu 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  28

Tyr Asp Leu Gly Ser Ile 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  29

Tyr Asp Leu Gly Ser Val 
1               5       


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  30

Leu Gly Ser Leu 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  31

Ile Gly Ser Leu 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  32

Val Gly Ser Leu 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  33

Leu Pro Ser Leu 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  34

Leu Gly Ile Leu 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  35

Leu Gly Ser Ile 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  36

Leu Gly Ser Val 
1               


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  37

Ala Leu Ser Thr Asp Arg Gly Lys Thr Leu Val 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  38

Ala Leu Thr Ser Asp Arg Gly Lys Thr Leu Val 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  39

Ala Leu Thr Thr Asp Arg Gly Lys Ser Leu Val 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  40

Ala Leu Thr Thr Asp Arg Pro Lys Thr Leu Val 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  41

Ala Leu Thr Thr Asp Arg Gly Arg Thr Leu Val 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  42

Ala Leu Thr Thr Asp Lys Gly Lys Thr Leu Val 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  43

Ala Leu Thr Thr Asp Lys Gly Lys Thr Leu Val 
1               5                   10      


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  44

Arg Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  45

Lys Ala Asp Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  46

Lys Ala Glu Phe Trp Leu Glu Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  47

Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Arg Val 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  48

Lys Ala Glu Tyr Trp Leu Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  49

Lys Ala Glu Phe Trp Ile Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  50

Lys Ala Glu Phe Trp Val Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  51
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  51

Lys Ala Glu Phe Trp Leu Asp Ile Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  52

Lys Ala Glu Phe Trp Leu Asp Val Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  53

Lys Ala Glu Phe Trp Leu Asp Leu Asn Pro Gln Ala Lys Val 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  54

Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Asn Ala Lys Val 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  55

Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys Ile 
1               5                   10                  


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  56

Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys Leu 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  57

Lys Ala Glu Phe Trp Ala Asp Leu Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  58

Lys Ala Glu Phe Trp Leu Asp Ala Gln Pro Gln Ala Lys Val 
1               5                   10                  


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  59

Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala Lys Ala 
1               5                   10                  


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  60

Lys Ala Glu Phe Trp Leu Asp 
1               5           


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  61

Asp Leu Gln Pro Gln Ala Lys Val 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  62

Glu Phe Trp Leu Asp Leu Gln Pro 
1               5               


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  63

Leu Asp Leu Gln Pro Gln Ala 
1               5           


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  64

Leu Gln Pro Gln Ala Lys Val 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  65

Ala Glu Phe Trp Leu Asp Leu 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  66

Trp Leu Asp Leu Gln Pro Gln 
1               5           


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  67

Ser Pro Arg Pro Tyr Ser Asn Phe 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  68

Arg Pro Tyr Ser Asn Phe Asp Gln 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  69

Ser Asn Phe Asp Gln Glu Phe Leu 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  70

Asp Gln Glu Phe Leu Asn Glu Lys 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  71

Phe Leu Asn Glu Lys Ala Arg Leu 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  72

Leu Ile Asp Ser Met Asp Gln Ser 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  73

Ser Met Asp Gln Ser Ala Phe Ala 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  74

Asp Gln Ser Ala Phe Ala Gly Phe 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  75

Phe Val Asn Pro Lys Phe Glu His 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  76

Lys Phe Glu His Leu Leu Glu Asp 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  77

Asn Glu Lys Ala Arg Leu Ser Tyr 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  78

Arg Leu Ser Tyr Ser Asp Lys Asn 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  79

Ser Tyr Ser Asp Lys Asn Leu Ile 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  80

Asp Lys Asn Leu Ile Asp Ser Met 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  81

Pro Phe Arg Pro Lys Val Lys Ser 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  82

Arg Pro Lys Val Lys Ser Pro Arg 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  83

Val Lys Ser Pro Arg Pro Tyr Ser 
1               5               


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  84

Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transactivating Regulatory Protein (Tat)-derived transport 
       polypeptide from the Human Immunodeficiency Virus, Type 1

<400>  85

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  86
<211>  673
<212>  PRT
<213>  Rattus norvegicus

<400>  86

Met Ala Pro Phe Leu Arg Ile Ser Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Asp Ala Ser Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Thr Thr Asp Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Asp Pro 
65                  70                  75                  80  


Met Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Cys Val Gln Tyr Phe Leu Glu Asp Gly Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Glu Glu Ala Met Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Thr Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Lys Ala Ser Arg Lys Pro Glu Thr 
    290                 295                 300                 


Pro Glu Thr Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr Ala Val 
305                 310                 315                 320 


Ser Gly Asn Asp Ile Pro Asp Asn Asn Gly Thr Tyr Gly Lys Ile Trp 
                325                 330                 335     


Glu Gly Ser Asn Arg Cys Arg Leu Glu Asn Phe Thr Phe Gln Lys Val 
            340                 345                 350         


Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Glu Leu Lys Gly 
        355                 360                 365             


Lys Glu Arg Tyr Phe Ala Ile Lys Tyr Leu Lys Lys Asp Val Val Leu 
    370                 375                 380                 


Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala 
385                 390                 395                 400 


Leu Ala Trp Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr Phe Gln 
                405                 410                 415     


Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly Gly Asp 
            420                 425                 430         


Leu Met Phe His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr Arg Ala 
        435                 440                 445             


Thr Phe Tyr Ala Ala Glu Ile Ile Cys Gly Leu Gln Phe Leu His Gly 
    450                 455                 460                 


Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp 
465                 470                 475                 480 


Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn 
                485                 490                 495     


Ile Phe Gly Glu Asn Arg Ala Ser Thr Phe Cys Gly Thr Pro Asp Tyr 
            500                 505                 510         


Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Ser Phe Ser Val Asp 
        515                 520                 525             


Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln Ser 
    530                 535                 540                 


Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile Arg Val 
545                 550                 555                 560 


Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys Asp Ile 
                565                 570                 575     


Met Glu Lys Leu Phe Glu Arg Asp Pro Ala Lys Arg Leu Gly Val Thr 
            580                 585                 590         


Gly Asn Ile Arg Leu His Pro Phe Phe Lys Thr Ile Asn Trp Asn Leu 
        595                 600                 605             


Leu Glu Lys Arg Lys Val Glu Pro Pro Phe Lys Pro Lys Val Lys Ser 
    610                 615                 620                 


Pro Ser Asp Tyr Ser Asn Phe Asp Pro Glu Phe Leu Asn Glu Lys Pro 
625                 630                 635                 640 


Gln Leu Ser Phe Ser Asp Lys Asn Leu Ile Asp Ser Met Asp Gln Thr 
                645                 650                 655     


Ala Phe Lys Gly Phe Ser Phe Val Asn Pro Lys Tyr Glu Gln Phe Leu 
            660                 665                 670         


Glu 
    


<210>  87
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu Asp 
        675     


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  delta-PKC peptide, delta-V1-7

<400>  88

Met Arg Ala Ala Glu Asp Pro Met 
1               5               


<210>  89
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  DISULFID
<222>  (12)..(13)

<400>  89

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Cys Ser Phe Asn 
1               5                   10                  15      


Ser Tyr Glu Leu Gly Ser Leu 
            20              


Page 1

