                         SEQUENCE LISTING

<110>  Baylor Research Institute
       Zurawski, Gerard
 
<120>  MULTIVARIABLE ANTIGENS COMPLEXED WITH TARGETING HUMANIZED 
       MONOCLONAL ANTIBODY

<130>  BHCS:2094

<150>  US 60/888,029
<151>  2007-02-02

<160>  43    

<170>  PatentIn version 3.4

<210>  1
<211>  2299
<212>  PRT
<213>  Bacteroides cellulosolvens

<400>  1

Met Gln Ser Pro Arg Leu Lys Arg Lys Ile Leu Ser Val Ile Leu Ala 
1               5                   10                  15      


Val Cys Tyr Ile Ile Ser Ser Phe Ser Ile Gln Phe Ala Ala Thr Pro 
            20                  25                  30          


Gln Val Asn Ile Ile Ile Gly Ser Ala Gln Gly Ile Pro Gly Ser Thr 
        35                  40                  45              


Val Lys Val Pro Ile Asn Leu Gln Asn Val Pro Glu Ile Gly Ile Asn 
    50                  55                  60                  


Asn Cys Asp Phe Thr Ile Lys Phe Asp Ser Asp Ile Leu Asp Phe Asn 
65                  70                  75                  80  


Ser Val Glu Ala Gly Asp Ile Val Pro Leu Pro Val Ala Ser Phe Ser 
                85                  90                  95      


Ser Asn Asn Ser Lys Asp Ile Ile Lys Phe Leu Phe Ser Asp Ala Thr 
            100                 105                 110         


Gln Gly Asn Met Pro Ile Asn Glu Asn Gly Leu Phe Ala Val Ile Ser 
        115                 120                 125             


Phe Lys Ile Lys Asp Asn Ala Gln Lys Gly Ile Ser Asn Ile Lys Val 
    130                 135                 140                 


Ser Ser Tyr Gly Ser Phe Ser Gly Met Ser Gly Lys Glu Met Gln Ser 
145                 150                 155                 160 


Leu Ser Pro Thr Phe Phe Ser Gly Ser Ile Asp Val Ser Asp Val Ser 
                165                 170                 175     


Thr Ser Lys Leu Asp Val Lys Val Gly Asn Val Glu Gly Ile Ala Gly 
            180                 185                 190         


Thr Glu Val Asn Val Pro Ile Thr Phe Glu Asn Val Pro Asp Asn Gly 
        195                 200                 205             


Ile Asn Asn Cys Asn Phe Thr Leu Ser Tyr Asp Ser Asn Ala Leu Glu 
    210                 215                 220                 


Phe Leu Thr Thr Glu Ala Gly Asn Ile Ile Pro Leu Ala Ile Ala Asp 
225                 230                 235                 240 


Tyr Ser Ser Tyr Arg Ser Met Glu Gly Lys Ile Lys Phe Leu Phe Ser 
                245                 250                 255     


Asp Ser Ser Gln Gly Thr Arg Ser Ile Lys Asn Asp Gly Val Phe Ala 
            260                 265                 270         


Asn Ile Lys Phe Lys Ile Lys Gly Asn Ala Ile Arg Asp Thr Tyr Arg 
        275                 280                 285             


Ile Asp Leu Ser Glu Leu Gly Ser Phe Ser Ser Lys Gln Asn Asn Asn 
    290                 295                 300                 


Leu Lys Ser Ile Ala Thr Gln Phe Leu Ser Gly Ser Val Asn Val Lys 
305                 310                 315                 320 


Asp Ile Glu Ser Ser Val Ser Pro Thr Thr Ser Val His Pro Thr Pro 
                325                 330                 335     


Thr Ser Val Pro Pro Thr Pro Thr Lys Ser Ser Pro Gly Asn Lys Met 
            340                 345                 350         


Lys Ile Gln Ile Gly Asp Val Lys Ala Asn Gln Gly Asp Thr Val Ile 
        355                 360                 365             


Val Pro Ile Thr Phe Asn Glu Val Pro Val Met Gly Val Asn Asn Cys 
    370                 375                 380                 


Asn Phe Thr Leu Ala Tyr Asp Lys Asn Ile Met Glu Phe Ile Ser Ala 
385                 390                 395                 400 


Asp Ala Gly Asp Ile Val Thr Leu Pro Met Ala Asn Tyr Ser Tyr Asn 
                405                 410                 415     


Met Pro Ser Asp Gly Leu Val Lys Phe Leu Tyr Asn Asp Gln Ala Gln 
            420                 425                 430         


Gly Ala Met Ser Ile Lys Glu Asp Gly Thr Phe Ala Asn Val Lys Phe 
        435                 440                 445             


Lys Ile Lys Gln Ser Ala Ala Phe Gly Lys Tyr Ser Val Gly Ile Lys 
    450                 455                 460                 


Ala Ile Gly Ser Ile Ser Ala Leu Ser Asn Ser Lys Leu Ile Pro Ile 
465                 470                 475                 480 


Glu Ser Ile Phe Lys Asp Gly Ser Ile Thr Val Thr Asn Lys Pro Ile 
                485                 490                 495     


Val Asn Ile Glu Ile Gly Lys Val Lys Val Lys Ala Gly Asp Lys Ile 
            500                 505                 510         


Lys Val Pro Val Glu Ile Lys Asp Ile Pro Ser Ile Gly Ile Asn Asn 
        515                 520                 525             


Cys Asn Phe Thr Leu Lys Tyr Asn Ser Asn Val Leu Lys Tyr Val Ser 
    530                 535                 540                 


Asn Glu Ala Gly Thr Ile Val Pro Ala Pro Leu Ala Asn Leu Ser Ile 
545                 550                 555                 560 


Asn Lys Pro Asp Glu Gly Ile Ile Lys Leu Leu Phe Ser Asp Ala Ser 
                565                 570                 575     


Gln Gly Gly Met Pro Ile Lys Asp Asn Gly Ile Phe Val Asn Leu Glu 
            580                 585                 590         


Phe Gln Ala Val Asn Asp Ala Asn Ile Gly Val Tyr Gly Leu Glu Leu 
        595                 600                 605             


Asp Thr Ile Gly Ala Phe Ser Gly Ile Ser Ser Ala Lys Met Thr Ser 
    610                 615                 620                 


Ile Glu Pro Gln Phe Asn Asn Gly Ser Ile Glu Ile Phe Asn Ser Ala 
625                 630                 635                 640 


Gln Thr Pro Val Pro Ser Asn Thr Glu Val Gln Thr Pro Thr Asn Thr 
                645                 650                 655     


Ile Ser Val Thr Pro Thr Asn Asn Ser Thr Pro Thr Asn Asn Ser Thr 
            660                 665                 670         


Pro Lys Pro Asn Pro Leu Tyr Asn Leu Asn Val Asn Ile Gly Glu Ile 
        675                 680                 685             


Ser Gly Glu Ala Gly Gly Val Ile Glu Val Pro Ile Glu Phe Lys Asn 
    690                 695                 700                 


Val Pro Asp Phe Gly Ile Asn Asn Cys Asp Phe Ser Val Lys Tyr Asp 
705                 710                 715                 720 


Lys Ser Ile Phe Glu Tyr Val Thr Tyr Glu Ala Gly Ser Ile Val Lys 
                725                 730                 735     


Asp Ser Ile Val Asn Leu Ala Cys Met Glu Asn Ser Gly Ile Ile Asn 
            740                 745                 750         


Leu Leu Phe Asn Asp Ala Thr Gln Ser Ser Ser Pro Ile Lys Asn Asn 
        755                 760                 765             


Gly Val Phe Ala Lys Leu Lys Phe Lys Ile Asn Ser Asn Ala Ala Ser 
    770                 775                 780                 


Gly Thr Tyr Gln Ile Asn Ala Glu Gly Tyr Gly Lys Phe Ser Gly Asn 
785                 790                 795                 800 


Leu Asn Gly Lys Leu Thr Ser Ile Asn Pro Ile Phe Glu Asn Gly Ile 
                805                 810                 815     


Ile Asn Ile Gly Asn Val Thr Val Lys Pro Thr Ser Thr Pro Ala Asp 
            820                 825                 830         


Ser Ser Thr Ile Thr Pro Thr Ala Thr Pro Thr Ala Thr Pro Thr Ile 
        835                 840                 845             


Lys Gly Thr Pro Thr Val Thr Pro Ile Tyr Trp Met Asn Val Leu Ile 
    850                 855                 860                 


Gly Asn Met Asn Ala Ala Ile Gly Glu Glu Val Val Val Pro Ile Glu 
865                 870                 875                 880 


Phe Lys Asn Val Pro Pro Phe Gly Ile Asn Asn Cys Asp Phe Lys Leu 
                885                 890                 895     


Val Tyr Asp Ser Asn Ala Leu Glu Leu Lys Lys Val Glu Ala Gly Asp 
            900                 905                 910         


Ile Val Pro Glu Pro Leu Ala Asn Leu Ser Ser Asn Lys Ser Glu Gly 
        915                 920                 925             


Lys Ile Gln Phe Leu Phe Asn Asp Ala Ser Gln Gly Ser Met Gln Ile 
    930                 935                 940                 


Glu Asn Gly Gly Val Phe Ala Lys Ile Thr Phe Lys Val Lys Ser Thr 
945                 950                 955                 960 


Ala Ala Ser Gly Ile Tyr Asn Ile Arg Lys Asp Ser Val Gly Ser Phe 
                965                 970                 975     


Ser Gly Leu Ile Asp Asn Lys Met Thr Ser Ile Gly Pro Lys Phe Thr 
            980                 985                 990         


Asp Gly Ser Ile Val Val Gly Thr  Val Thr Pro Thr Ala  Thr Ala Thr 
        995                 1000                 1005             


Pro Ser  Ala Ile Val Thr Thr  Ile Thr Pro Thr Ala  Thr Thr Lys 
    1010                 1015                 1020             


Pro Ile  Ala Thr Pro Thr Ile  Lys Gly Thr Pro Thr  Ala Thr Pro 
    1025                 1030                 1035             


Met Tyr  Trp Met Asn Val Val  Ile Gly Lys Met Asn  Ala Glu Val 
    1040                 1045                 1050             


Gly Gly  Glu Val Val Val Pro  Ile Glu Phe Asn Asn  Val Pro Ser 
    1055                 1060                 1065             


Phe Gly  Ile Asn Asn Cys Asp  Phe Lys Leu Val Tyr  Asp Ala Thr 
    1070                 1075                 1080             


Ala Leu  Glu Leu Lys Asn Val  Glu Ala Gly Asp Ile  Ile Lys Thr 
    1085                 1090                 1095             


Pro Leu  Ala Asn Phe Ser Asn  Asn Lys Ser Glu Glu  Gly Lys Ile 
    1100                 1105                 1110             


Ser Phe  Leu Phe Asn Asp Ala  Ser Gln Gly Ser Met  Gln Ile Glu 
    1115                 1120                 1125             


Asn Gly  Gly Val Phe Ala Lys  Ile Thr Phe Lys Val  Lys Ser Thr 
    1130                 1135                 1140             


Thr Ala  Thr Gly Val Tyr Asp  Leu Arg Lys Asp Leu  Val Gly Ser 
    1145                 1150                 1155             


Phe Ser  Gly Leu Lys Asp Asn  Lys Met Thr Ser Ile  Gly Ala Glu 
    1160                 1165                 1170             


Phe Thr  Asn Gly Ser Ile Thr  Val Ala Ala Thr Ala  Pro Thr Val 
    1175                 1180                 1185             


Thr Pro  Thr Val Asn Ala Thr  Pro Ser Ala Ala Thr  Pro Thr Val 
    1190                 1195                 1200             


Thr Pro  Thr Ala Thr Ala Thr  Pro Ser Val Thr Ile  Pro Thr Val 
    1205                 1210                 1215             


Thr Pro  Thr Ala Thr Ala Thr  Pro Ser Val Thr Ile  Pro Thr Val 
    1220                 1225                 1230             


Thr Pro  Thr Ala Thr Ala Thr  Pro Ser Ala Ala Thr  Pro Thr Val 
    1235                 1240                 1245             


Thr Pro  Thr Ala Thr Ala Thr  Pro Ser Val Thr Ile  Pro Thr Val 
    1250                 1255                 1260             


Thr Pro  Thr Val Thr Ala Thr  Pro Ser Asp Thr Ile  Pro Thr Val 
    1265                 1270                 1275             


Thr Pro  Thr Ala Thr Ala Thr  Pro Ser Ala Ile Val  Thr Thr Ile 
    1280                 1285                 1290             


Thr Pro  Thr Ala Thr Ala Lys  Pro Ile Ala Thr Pro  Thr Ile Lys 
    1295                 1300                 1305             


Gly Thr  Pro Thr Ala Thr Pro  Met Tyr Trp Met Asn  Val Val Ile 
    1310                 1315                 1320             


Gly Lys  Met Asn Ala Glu Val  Gly Gly Glu Val Val  Val Pro Ile 
    1325                 1330                 1335             


Glu Phe  Lys Asn Val Pro Ser  Phe Gly Ile Asn Asn  Cys Asp Phe 
    1340                 1345                 1350             


Lys Leu  Val Tyr Asp Ala Thr  Ala Leu Glu Leu Lys  Asn Val Glu 
    1355                 1360                 1365             


Ala Gly  Asp Ile Ile Lys Thr  Pro Leu Ala Asn Phe  Ser Asn Asn 
    1370                 1375                 1380             


Lys Ser  Glu Glu Gly Lys Ile  Ser Phe Leu Phe Asn  Asp Ala Ser 
    1385                 1390                 1395             


Gln Gly  Ser Met Gln Ile Glu  Asn Gly Gly Val Ser  Ala Lys Ile 
    1400                 1405                 1410             


Thr Phe  Lys Val Lys Ser Thr  Thr Ala Ile Gly Val  Tyr Asp Ile 
    1415                 1420                 1425             


Arg Lys  Asp Leu Ile Gly Ser  Phe Ser Gly Leu Lys  Asp Ser Lys 
    1430                 1435                 1440             


Met Thr  Ser Ile Gly Ala Glu  Phe Thr Asn Gly Ser  Ile Thr Val 
    1445                 1450                 1455             


Ala Thr  Thr Ala Pro Thr Val  Thr Pro Thr Ala Thr  Ala Thr Pro 
    1460                 1465                 1470             


Ser Val  Thr Ile Pro Thr Val  Thr Pro Thr Ala Thr  Ala Thr Pro 
    1475                 1480                 1485             


Gly Thr  Ala Thr Pro Gly Thr  Ala Thr Pro Thr Ala  Thr Ala Thr 
    1490                 1495                 1500             


Pro Gly  Ala Ala Thr Pro Thr  Glu Thr Ala Thr Pro  Ser Val Met 
    1505                 1510                 1515             


Ile Pro  Thr Val Thr Pro Thr  Ala Thr Ala Thr Pro  Thr Ala Thr 
    1520                 1525                 1530             


Ala Thr  Pro Thr Val Lys Gly  Thr Pro Thr Ile Lys  Pro Val Tyr 
    1535                 1540                 1545             


Lys Met  Asn Val Val Ile Gly  Arg Val Asn Val Val  Ala Gly Glu 
    1550                 1555                 1560             


Glu Val  Val Val Pro Val Glu  Phe Lys Asn Ile Pro  Ala Ile Gly 
    1565                 1570                 1575             


Val Asn  Asn Cys Asn Phe Val  Leu Glu Tyr Asp Ala  Asn Val Leu 
    1580                 1585                 1590             


Glu Val  Lys Lys Val Asp Ala  Gly Glu Ile Val Pro  Asp Ala Leu 
    1595                 1600                 1605             


Ile Asn  Phe Gly Ser Asn Asn  Ser Asp Glu Gly Lys  Val Tyr Phe 
    1610                 1615                 1620             


Leu Phe  Asn Asp Ala Leu Gln  Gly Arg Met Gln Ile  Ala Asn Asp 
    1625                 1630                 1635             


Gly Ile  Phe Ala Asn Ile Thr  Phe Lys Val Lys Ser  Ser Ala Ala 
    1640                 1645                 1650             


Ala Gly  Ile Tyr Asn Ile Arg  Lys Asp Ser Val Gly  Ala Phe Ser 
    1655                 1660                 1665             


Gly Leu  Val Asp Lys Leu Val  Pro Ile Ser Ala Glu  Phe Thr Asp 
    1670                 1675                 1680             


Gly Ser  Ile Ser Val Glu Ser  Ala Lys Ser Thr Pro  Thr Ala Thr 
    1685                 1690                 1695             


Ala Thr  Gly Thr Asn Val Thr  Pro Thr Val Ala Ala  Thr Val Thr 
    1700                 1705                 1710             


Pro Thr  Ala Thr Pro Ala Ser  Thr Thr Pro Thr Ala  Thr Pro Thr 
    1715                 1720                 1725             


Ala Thr  Ser Thr Val Lys Gly  Thr Pro Thr Ala Thr  Pro Leu Tyr 
    1730                 1735                 1740             


Ser Met  Asn Val Ile Ile Gly  Lys Val Asn Ala Glu  Ala Ser Gly 
    1745                 1750                 1755             


Glu Val  Val Val Pro Val Glu  Phe Lys Asp Val Pro  Ser Ile Gly 
    1760                 1765                 1770             


Ile Asn  Asn Cys Asn Phe Ile  Leu Glu Tyr Asp Ala  Ser Ala Leu 
    1775                 1780                 1785             


Glu Leu  Asp Ser Ala Glu Ala  Gly Glu Ile Val Pro  Val Pro Leu 
    1790                 1795                 1800             


Gly Asn  Phe Ser Ser Asn Asn  Lys Asp Glu Gly Lys  Ile Tyr Phe 
    1805                 1810                 1815             


Leu Phe  Ser Asp Gly Thr Gln  Gly Arg Met Gln Ile  Val Asn Asp 
    1820                 1825                 1830             


Gly Ile  Phe Ala Lys Ile Lys  Phe Lys Val Lys Ser  Thr Ala Ser 
    1835                 1840                 1845             


Asp Gly  Thr Tyr Tyr Ile Arg  Lys Asp Ser Val Gly  Ala Phe Ser 
    1850                 1855                 1860             


Gly Leu  Ile Glu Lys Lys Ile  Ile Lys Ile Gly Ala  Glu Phe Thr 
    1865                 1870                 1875             


Asp Gly  Ser Ile Thr Val Arg  Ser Leu Thr Pro Thr  Pro Thr Val 
    1880                 1885                 1890             


Thr Pro  Asn Val Ala Ser Pro  Thr Pro Thr Lys Val  Val Ala Glu 
    1895                 1900                 1905             


Pro Thr  Ser Asn Gln Pro Ala  Gly Pro Gly Pro Ile  Thr Gly Thr 
    1910                 1915                 1920             


Ile Pro  Thr Ala Thr Thr Thr  Ala Thr Ala Thr Pro  Thr Lys Ala 
    1925                 1930                 1935             


Ser Val  Ala Thr Ala Thr Pro  Thr Ala Thr Pro Ile  Val Val Val 
    1940                 1945                 1950             


Glu Pro  Thr Ile Val Arg Pro  Gly Tyr Asn Lys Asp  Ala Asp Leu 
    1955                 1960                 1965             


Ala Val  Phe Ile Ser Ser Asp  Lys Ser Arg Tyr Glu  Glu Ser Ser 
    1970                 1975                 1980             


Ile Ile  Thr Tyr Ser Ile Glu  Tyr Lys Asn Ile Gly  Lys Val Asn 
    1985                 1990                 1995             


Ala Thr  Asn Val Lys Ile Ala  Ala Gln Ile Pro Lys  Phe Thr Lys 
    2000                 2005                 2010             


Val Tyr  Asp Ala Ala Lys Gly  Ala Val Lys Gly Ser  Glu Ile Val 
    2015                 2020                 2025             


Trp Met  Ile Gly Asn Leu Ala  Val Gly Glu Ser Tyr  Thr Lys Glu 
    2030                 2035                 2040             


Tyr Lys  Val Lys Val Asp Ser  Leu Thr Lys Ser Glu  Glu Tyr Thr 
    2045                 2050                 2055             


Asp Asn  Thr Val Thr Ile Ser  Ser Asp Gln Thr Val  Asp Ile Pro 
    2060                 2065                 2070             


Glu Asn  Ile Thr Thr Gly Asn  Asp Asp Lys Ser Thr  Ile Arg Val 
    2075                 2080                 2085             


Met Leu  Tyr Ser Asn Arg Phe  Thr Pro Gly Ser His  Ser Ser Tyr 
    2090                 2095                 2100             


Ile Leu  Gly Tyr Lys Asp Lys  Thr Phe Lys Pro Lys  Gln Asn Val 
    2105                 2110                 2115             


Thr Arg  Ala Glu Val Ala Ala  Met Phe Ala Arg Ile  Met Gly Leu 
    2120                 2125                 2130             


Thr Val  Lys Asp Gly Ala Lys  Ser Ser Tyr Lys Asp  Val Ser Asn 
    2135                 2140                 2145             


Lys His  Trp Ala Leu Lys Tyr  Ile Glu Ala Val Thr  Lys Ser Gly 
    2150                 2155                 2160             


Ile Phe  Lys Gly Tyr Lys Asp  Ser Thr Phe His Pro  Asn Ala Pro 
    2165                 2170                 2175             


Ile Thr  Arg Ala Glu Leu Ser  Thr Val Ile Phe Asn  Tyr Leu His 
    2180                 2185                 2190             


Leu Asn  Asn Ile Ala Pro Ser  Lys Val His Phe Thr  Asp Ile Asn 
    2195                 2200                 2205             


Lys His  Trp Ala Lys Asn Tyr  Ile Glu Glu Ile Tyr  Arg Phe Lys 
    2210                 2215                 2220             


Leu Ile  Gln Gly Tyr Ser Asp  Gly Ser Phe Lys Pro  Asn Asn Asn 
    2225                 2230                 2235             


Ile Thr  Arg Ala Glu Val Val  Thr Met Ile Asn Arg  Met Leu Tyr 
    2240                 2245                 2250             


Arg Gly  Pro Leu Lys Val Lys  Val Gly Ser Phe Pro  Asp Val Ser 
    2255                 2260                 2265             


Pro Lys  Tyr Trp Ala Tyr Gly  Asp Ile Glu Glu Ala  Ser Arg Asn 
    2270                 2275                 2280             


His Lys  Tyr Thr Arg Asp Glu  Lys Asp Gly Ser Glu  Ile Leu Ile 
    2285                 2290                 2295             


Glu 
    


<210>  2
<211>  1653
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  2
atggacctcc tgtgcaagaa catgaagcac ctgtggttct tcctcctgct ggtggcggct     60

cccagatggg tcctgtcccg gctgcagctg caggagtcgg gcccaggcct gctgaagcct    120

tcggtgaccc tgtccctcac ctgcactgtc tcgggtgact ccgtcgccag tagttcttat    180

tactggggct gggtccgtca gcccccaggg aagggactcg agtggatagg gactatcaat    240

tttagtggca atatgtatta tagtccgtcc ctcaggagtc gagtgaccat gtcggcagac    300

atgtccgaga actccttcta tctgaaattg gactctgtga ccgcagcaga cacggccgtc    360

tattattgtg cggcaggaca cctcgttatg ggatttgggg cccactgggg acagggaaaa    420

ctggtctccg tctctccagc ttccaccaag ggcccatccg tcttccccct ggcgccctgc    480

tccaggagca cctccgagag cacagccgcc ctgggctgcc tggtcaagga ctacttcccc    540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg    600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc    660

agcttgggca cgaagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg    720

gacaagagag ttgagtccaa atatggtccc ccatgcccac cctgcccagc acctgagttc    780

gaagggggac catcagtctt cctgttcccc ccaaaaccca aggacactct catgatctcc    840

cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc cgaggtccag    900

ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag    960

cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg   1020

aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc catcgagaaa   1080

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc   1140

caggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc   1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg   1260

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaggctaac cgtggacaag   1320

agcaggtggc aggaggggaa tgtcttctca tgctccgtga tgcatgaggc tctgcacaac   1380

cactacacac agaagagcct ctccctgtct ctgggtaaag ctagcaattc tcctcaaaat   1440

gaagtactgt acggagatgt gaatgatgac ggaaaagtaa actccactga cttgactttg   1500

ttaaaaagat atgttcttaa agccgtctca actctccctt cttccaaagc tgaaaagaac   1560

gcagatgtaa atcgtgacgg aagagttaat tccagtgatg tcacaatact ttcaagatat   1620

ttgataaggg taatcgagaa attaccaata taa                                1653


<210>  3
<211>  524
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  3

Arg Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Val 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ala Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Asn Phe Ser Gly Asn Met Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Met Ser Ala Asp Met Ser Glu Asn Ser Phe 
65                  70                  75                  80  


Tyr Leu Lys Leu Asp Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly His Leu Val Met Gly Phe Gly Ala His Trp Gly Gln 
            100                 105                 110         


Gly Lys Leu Val Ser Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala 
        435                 440                 445             


Ser Asn Ser Pro Gln Asn Glu Val Leu Tyr Gly Asp Val Asn Asp Asp 
    450                 455                 460                 


Gly Lys Val Asn Ser Thr Asp Leu Thr Leu Leu Lys Arg Tyr Val Leu 
465                 470                 475                 480 


Lys Ala Val Ser Thr Leu Pro Ser Ser Lys Ala Glu Lys Asn Ala Asp 
                485                 490                 495     


Val Asn Arg Asp Gly Arg Val Asn Ser Ser Asp Val Thr Ile Leu Ser 
            500                 505                 510         


Arg Tyr Leu Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520                 


<210>  4
<211>  1635
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  4
atgaaatgca gctgggtcat cttcttcctg atggcagtgg ttacaggggt caattcagag     60

gttcagctgc agcagtctgg ggctgagctt gtgaggccag gggccttagt caagttgtcc    120

tgcaaagctt ctggcttcaa cattaatgac tactatatcc actgggtgaa gcagcggcct    180

gaacagggcc tggagcggat tggatggatt gatcctgaca atggtaatac tatatatgac    240

ccgaagttcc agggcaaggc cagtataaca gcagacacat cccccaacac agcctacctg    300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag aacccgatct    360

cctatggtta cgacggggtt tgtttactgg ggccaaggga ctgtggtcac tgtctctgca    420

gccaaaacga agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag    480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc    660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc    720

aaatatggtc ccccatgccc accctgccca gcacctgagt tcgaaggggg accatcagtc    780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg    840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat    900

ggcgtggagg tgcataatgc caagacraag ccgcgggagg agcagttcaa cagcacgtac    960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag   1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa   1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag   1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag   1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc   1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg   1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc   1380

ctctccctgt ctctgggtaa agctagcaat tctcctcaaa atgaagtact gtacggagat   1440

gtgaatgatg acggaaaagt aaactccact gacttgactt tgttaaaaag atatgttctt   1500

aaagccgtct caactctccc ttcttccaaa gctgaaaaga acgcagatgt aaatcgtgac   1560

ggaagagtta attccagtga tgtcacaata ctttcaagat atttgataag ggtaatcgag   1620

aaattaccaa tataa                                                    1635


<210>  5
<211>  525
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Asn Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Arg Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Asp Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Pro Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Arg Ser Pro Met Val Thr Thr Gly Phe Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Val Val Thr Val Ser Ala Ala Lys Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


Ala Ser Asn Ser Pro Gln Asn Glu Val Leu Tyr Gly Asp Val Asn Asp 
    450                 455                 460                 


Asp Gly Lys Val Asn Ser Thr Asp Leu Thr Leu Leu Lys Arg Tyr Val 
465                 470                 475                 480 


Leu Lys Ala Val Ser Thr Leu Pro Ser Ser Lys Ala Glu Lys Asn Ala 
                485                 490                 495     


Asp Val Asn Arg Asp Gly Arg Val Asn Ser Ser Asp Val Thr Ile Leu 
            500                 505                 510         


Ser Arg Tyr Leu Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520                 525 


<210>  6
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  6
atggacccca aaggctccct ttcctggaga atacttctgt ttctctccct ggcttttgag     60

ttgtcgtacg gagatgtgca gcttcaggag tcaggacctg acctggtgaa accttctcag    120

tcactttcac tcacctgcac tgtcactggc tactccatca ccagtggtta tagctggcac    180

tggatccggc agtttccagg aaacaaactg gaatggatgg gctacatact cttcagtggt    240

agcactaact acaacccatc tctgaaaagt cgaatctcta tcactcgaga cacatccaag    300

aaccagttct tcctgcagtt gaattctgtg actactgagg acacagccac atatttctgt    360

gcaagatcta actatggttc ctttgcttcc tggggccaag ggactctggt cactgtctct    420

gcagccaaaa caaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc    480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag    660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag    720

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcgaagg gggaccatca    780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc    840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg    900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg    960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac   1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc   1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc   1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg   1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac   1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag   1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag   1380

agcctctccc tgtctctggg taaagctagc aattctcctc aaaatgaagt actgtacgga   1440

gatgtgaatg atgacggaaa agtaaactcc actgacttga ctttgttaaa aagatatgtt   1500

cttaaagccg tctcaactct cccttcttcc aaagctgaaa agaacgcaga tgtaaatcgt   1560

gacggaagag ttaattccag tgatgtcaca atactttcaa gatatttgat aagggtaatc   1620

gagaaattac caatataa                                                 1638


<210>  7
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  7

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Leu Phe Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Gly Ser Phe Ala Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asn Ser 
        435                 440                 445             


Pro Gln Asn Glu Val Leu Tyr Gly Asp Val Asn Asp Asp Gly Lys Val 
    450                 455                 460                 


Asn Ser Thr Asp Leu Thr Leu Leu Lys Arg Tyr Val Leu Lys Ala Val 
465                 470                 475                 480 


Ser Thr Leu Pro Ser Ser Lys Ala Glu Lys Asn Ala Asp Val Asn Arg 
                485                 490                 495     


Asp Gly Arg Val Asn Ser Ser Asp Val Thr Ile Leu Ser Arg Tyr Leu 
            500                 505                 510         


Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520     


<210>  8
<211>  1623
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  8
atggaaaggc actggatctt tctcttcctg ttttcagtaa ctgcaggtgt ccactcccag     60

gtccagcttc agcagtctgg ggctgagctg gcaaaacctg gggcctcagt gaagatgtcc    120

tgcaaggctt ctggctacac ctttactacc tactggatgc actgggtaaa acagaggcct    180

ggacagggtc tggaatggat tggatacatt aatcctatca ctggttatac tgagtacaat    240

cagaagttca aggacaaggc caccttgact gcagacaaat cctccagcac agcctacatg    300

caactgagca gcctgacatc tgaggactct gcagtctatt actgtgcaag agagggttta    360

agtgctatgg actattgggg tcagggaacc tcagtcaccg tcacctcagc caaaacaacg    420

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc    480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac    660

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttgagtccaa atatggtccc    720

ccatgcccac cctgcccagc acctgagttc gaagggggac catcagtctt cctgttcccc    780

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg    900

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc    960

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga   1080

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1260

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct   1380

ctgggtaaag ctagcaattc tcctcaaaat gaagtactgt acggagatgt gaatgatgac   1440

ggaaaagtaa actccactga cttgactttg ttaaaaagat atgttcttaa agccgtctca   1500

actctccctt cttccaaagc tgaaaagaac gcagatgtaa atcgtgacgg aagagttaat   1560

tccagtgatg tcacaatact ttcaagatat ttgataaggg taatcgagaa attaccaata   1620

taa                                                                 1623


<210>  9
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ile Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Leu Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Thr Ser Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asn Ser 
        435                 440                 445             


Pro Gln Asn Glu Val Leu Tyr Gly Asp Val Asn Asp Asp Gly Lys Val 
    450                 455                 460                 


Asn Ser Thr Asp Leu Thr Leu Leu Lys Arg Tyr Val Leu Lys Ala Val 
465                 470                 475                 480 


Ser Thr Leu Pro Ser Ser Lys Ala Glu Lys Asn Ala Asp Val Asn Arg 
                485                 490                 495     


Asp Gly Arg Val Asn Ser Ser Asp Val Thr Ile Leu Ser Arg Tyr Leu 
            500                 505                 510         


Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520     


<210>  10
<211>  732
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  10
atgcatcgca ccagcatggg catcaagatg gagtcacaga ttcaggcatt tgtattcgtg     60

tttctctggt tgtctggtgt tggcggagac attgtgatga cccagtctca caaattcatg    120

tccacatcag taggagacag ggtcagcgtc acctgcaagg ccagtcagga tgtgacttct    180

gctgtagcct ggtatcaaca aaaaccaggg caatctccta aactactgat ttactgggca    240

tccacccggc acactggagt ccctgatcgc ttcacaggca gtggatctgg gacagattat    300

actctcacca tcagcagtgg gcaggctgaa gacctggcac tttattactg tcaccaatat    360

tatagcgctc ctcggacgtt cggtggaggc accaagctcg agatcaaacg aactgtggct    420

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct    480

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat    540

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc    600

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc    660

tatgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg    720

ggagagtgtt ag                                                        732


<210>  11
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  11

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asp Val Thr Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Gly Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys His Gln Tyr Tyr Ser Ala Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  1644
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  12
atgggatggt catgtatcat cctttttcta gtagcaactg caactggagt acattcacag     60

gtccaactgc agcagcctgg ggctgagctg gtgaggcctg ggacttcagt gaagttgtcc    120

tgcaaggctt ctggttacat ctttaccagc tactggatgc actgggtaaa gcagaggcct    180

ggacaaggcc ttgagtggat cggactgatt gatccttctg atagttatag taagtacaat    240

caaaagttca agggcaaggc cacattgact gtagacacat cctccagcac agcctacatg    300

cagctcagca gcctgacatc tgaggactct gcggtctatt actgtgcaag aggggagctc    360

agtgacttct ggggccaagg caccactctc acagtctcct cagccaaaac aacaccccca    420

tcagtctatc cactggcccc tgggtgtgga gatacaactg gttcctctgt gactctggga    480

tgcctggtca agggctactt ccctgagtca gtgactgtga cttggaactc tggatccctg    540

tccagcagtg tgcacacctt cccagctctc ctgcagtctg gactctacac tatgagcagc    600

tcagtgactg tcccctccag cacctggcca agtcagaccg tcacctgcag cgttgctcac    660

ccagccagca gcaccacggt ggacaaaaaa cttgagccca gcgggcccat ttcaacaatc    720

aacccctgtc ctccatgcaa ggagtgtcac aaatgcccag ctcctaacct cgagggtgga    780

ccatccgtct tcatcttccc tccaaatatc aaggatgtac tcatgatctc cctgacaccc    840

aaggtcacgt gtgtggtggt ggatgtgagc gaggatgacc cagacgtccg gatcagctgg    900

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac    960

agtactatcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag   1020

gagttcaaat gcaaggtcaa caacaaagac ctcccatcac ccatcgagag aaccatctca   1080

aaaattaaag ggctagtcag agctccacaa gtatacatct tgccgccacc agcagagcag   1140

ttgtccagga aagatgtcag tctcacttgc ctggtcgtgg gcttcaaccc tggagacatc   1200

agtgtggagt ggaccagcaa tgggcataca gaggagaact acaaggacac cgcaccagtc   1260

ctggactctg acggttctta cttcatatac agcaagctcg atataaaaac aagcaagtgg   1320

gagaaaacag attccttctc atgcaacgtg agacacgagg gtctgaaaaa ttactacctg   1380

aagaagacca tctcccggtc tccgggtaaa gctagcaatt ctcctcaaaa tgaagtactg   1440

tacggagatg tgaatgatga cggaaaagta aactccactg acttgacttt gttaaaaaga   1500

tatgttctta aagccgtctc aactctgcct tcttccaaag ctgaaaagaa cgcagatgta   1560

aatcgtgacg gaagagttaa ttccagtgat gtcacaatac tttcaagata tttgataagg   1620

gtaatcgaga aattaccaat ataa                                          1644


<210>  13
<211>  528
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  13

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asp Pro Ser Asp Ser Tyr Ser Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Leu Ser Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu 
                165                 170                 175     


Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val 
        195                 200                 205             


Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys 
    210                 215                 220                 


Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Arg Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu 
    370                 375                 380                 


Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asp Ile 
                405                 410                 415     


Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg 
            420                 425                 430         


His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser 
        435                 440                 445             


Pro Gly Lys Ala Ser Asn Ser Pro Gln Asn Glu Val Leu Tyr Gly Asp 
    450                 455                 460                 


Val Asn Asp Asp Gly Lys Val Asn Ser Thr Asp Leu Thr Leu Leu Lys 
465                 470                 475                 480 


Arg Tyr Val Leu Lys Ala Val Ser Thr Leu Pro Ser Ser Lys Ala Glu 
                485                 490                 495     


Lys Asn Ala Asp Val Asn Arg Asp Gly Arg Val Asn Ser Ser Asp Val 
            500                 505                 510         


Thr Ile Leu Ser Arg Tyr Leu Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520                 525             


<210>  14
<211>  2061
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  14
atggatccca aaggatccct ttcctggaga atacttctgt ttctctccct ggcttttgag     60

ttgagctacg gactcgacga tctggatgca gtaaggatta aagtggacac agtaaatgca    120

aaaccgggag acacagtaag aatacctgta agattcagcg gtataccatc caagggaata    180

gcaaactgtg actttgtata cagctatgac ccgaatgtac ttgagataat agagatagaa    240

ccgggagaca taatagttga cccgaatcct gacaagagct ttgatactgc agtatatcct    300

gacagaaaga taatagtatt cctgtttgca gaagacagcg gaacaggagc gtatgcaata    360

actaaagacg gagtatttgc tacgatagta gcgaaagtaa aagaaggagc acctaacgga    420

ctcagtgtaa tcaaatttgt agaagtaggc ggatttgcga acaatgacct tgtagaacag    480

aagacacagt tctttgacgg tggagtaaat gttggagata caacagaacc tgcaacacct    540

acaacacctg taacaacacc gacaacaaca gatgatctgg atgcactcga gatcatccca    600

gttgaggagg agaacccgga cttctggaac cgcgaggcag ccgaggccct gggtgccgcc    660

aagaagctgc agcctgcaca gacagccgcc aagaacctca tcatcttcct gggcgatggg    720

atgggggtgt ctacggtgac agctgccagg atcctaaaag ggcagaagaa ggacaaactg    780

gggcctgagt tacccctggc catggaccgc ttcccatatg tggctctgtc caagacatac    840

aatgtagaca aacatgtgcc agacagtgga gccacagcca cggcctacct gtgcggggtc    900

aagggcaact tccagaccat tggcttgagt gcagccgccc gctttaacca gtgcaacacg    960

acacgcggca acgaggtcat ctccgtgatg aatcgggcca agaaagcagg gaagtcagtg   1020

ggagtggtaa ccaccacacg agtgcagcac gcctcgccag ccggcaccta cgcccacacg   1080

gtgaaccgca actggtactc ggacgccgac gtgcctgcct cggcccgcca ggaggggtgc   1140

caggacatcg ctacgcagct catctccaac atggacattg acgtgatcct aggtggaggc   1200

cgaaagtaca tgtttcgcat gggaacccca gaccctgagt acccagatga ctacagccaa   1260

ggtgggacca ggctggacgg gaagaatctg gtgcaggaat ggctggcgaa gcgccagggt   1320

gcccggtacg tgtggaaccg cactgagctc atgcaggctt ccctggaccc gtctgtgacc   1380

catctcatgg gtctctttga gcctggagac atgaaatacg agatccaccg agactccaca   1440

ctggacccct ccctgatgga gatgacagag gctgccctgc gcctgctgag caggaacccc   1500

cgcggcttct tcctcttcgt ggagggtggt cgcatcgacc atggtcatca tgaaagcagg   1560

gcttaccggg cactgactga gacgatcatg ttcgacgacg ccattgagag ggcgggccag   1620

ctcaccagcg aggaggacac gctgagcctc gtcactgccg accactccca cgtcttctcc   1680

ttcggaggct accccctgcg agggagctcc atcttcgggc tggcccctgg caaggcccgg   1740

gacaggaagg cctacacggt cctcctatac ggaaacggtc caggctatgt gctcaaggac   1800

ggcgcccggc cggatgttac cgagagcgag agcgggagcc ccgagtatcg gcagcagtca   1860

gcagtgcccc tggacgaaga gacccacgca ggcgaggacg tggcggtgtt cgcgcgcggc   1920

ccgcaggcgc acctggttca cggcgtgcag gagcagacct tcatagcgca cgtcatggcc   1980

ttcgccgcct gcctggagcc ctacaccgcc tgcgacctgg cgccccccgc cggcaccacc   2040

caccatcacc atcaccattg a                                             2061


<210>  15
<211>  662
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  15

Leu Asp Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala 
1               5                   10                  15      


Lys Pro Gly Asp Thr Val Arg Ile Pro Val Arg Phe Ser Gly Ile Pro 
            20                  25                  30          


Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn 
        35                  40                  45              


Val Leu Glu Ile Ile Glu Ile Glu Pro Gly Glu Leu Ile Val Asp Pro 
    50                  55                  60                  


Asn Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met 
65                  70                  75                  80  


Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile 
                85                  90                  95      


Thr Glu Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Ser Gly 
            100                 105                 110         


Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe 
        115                 120                 125             


Ala Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly 
    130                 135                 140                 


Val Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val 
145                 150                 155                 160 


Thr Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Leu Glu Ile Ile Pro 
                165                 170                 175     


Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu Ala Ala Glu Ala 
            180                 185                 190         


Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr Ala Ala Lys Asn 
        195                 200                 205             


Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser Thr Val Thr Ala 
    210                 215                 220                 


Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu Gly Pro Glu Leu 
225                 230                 235                 240 


Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu Ser Lys Thr Tyr 
                245                 250                 255     


Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr Ala Thr Ala Tyr 
            260                 265                 270         


Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly Leu Ser Ala Ala 
        275                 280                 285             


Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn Glu Val Ile Ser 
    290                 295                 300                 


Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val Gly Val Val Thr 
305                 310                 315                 320 


Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr Tyr Ala His Thr 
                325                 330                 335     


Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro Ala Ser Ala Arg 
            340                 345                 350         


Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile Ser Asn Met Asp 
        355                 360                 365             


Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met Phe Arg Met Gly 
    370                 375                 380                 


Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln Gly Gly Thr Arg 
385                 390                 395                 400 


Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala Lys Arg Gln Gly 
                405                 410                 415     


Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln Ala Ser Leu Asp 
            420                 425                 430         


Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro Gly Asp Met Lys 
        435                 440                 445             


Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser Leu Met Glu Met 
    450                 455                 460                 


Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro Arg Gly Phe Phe 
465                 470                 475                 480 


Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His His Glu Ser Arg 
                485                 490                 495     


Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp Asp Ala Ile Glu 
            500                 505                 510         


Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu Ser Leu Val Thr 
        515                 520                 525             


Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr Pro Leu Arg Gly 
    530                 535                 540                 


Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg Asp Arg Lys Ala 
545                 550                 555                 560 


Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr Val Leu Lys Asp 
                565                 570                 575     


Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly Ser Pro Glu Tyr 
            580                 585                 590         


Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr His Ala Gly Glu 
        595                 600                 605             


Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His Leu Val His Gly 
    610                 615                 620                 


Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala Phe Ala Ala Cys 
625                 630                 635                 640 


Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro Ala Gly Thr Thr 
                645                 650                 655     


His His His His His His 
            660         


<210>  16
<211>  2556
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  16
atggatccca aaggatccct ttcctggaga atacttctgt ttctctccct ggcttttgag     60

ttgagctacg gactcgacga tctggatgca gtaaggatta aagtggacac agtaaatgca    120

aaaccgggag acacagtaag aatacctgta agattcagcg gtataccatc caagggaata    180

gcaaactgtg actttgtata cagctatgac ccgaatgtac ttgagataat agagataaaa    240

ccgggagaat tgatagttga cccgaatcct gacaagagct ttgatactgc agtatatcct    300

gacagaaaga taatagtatt cctgtttgca gaagacagcg gaacaggagc gtatgcaata    360

actaaagacg gagtatttgc tacgatagta gcgaaagtaa aatccggagc acctaacgga    420

ctcagtgtaa tcaaatttgt agaagtaggc ggatttgcga ataatgacct tgtagaacag    480

aagacacagt tctttgacgg tggagtaaat gttggagata caacagaacc tgcaacacct    540

acaacacctg taacaacacc gacaacaaca gatgatctgg atgcagtaag gattaaagtg    600

gacacagtaa atgcaaaacc gggagacaca gtaaatatac ctgtaagatt cagtggtata    660

ccatccaagg gaatagcaaa ctgtgacttt gtatacagct atgacccgaa tgtacttgag    720

ataatagaga taaaaccggg agaattgata gttgacccga atcctaccaa gagctttgat    780

actgcagtat atcctgacag aaagatgata gtattcctgt ttgcggaaga cagcggaaca    840

ggagcgtatg caataactaa agacggagta tttgctacga tagtagcgaa agtaaaagaa    900

ggagcaccta acggactcag tgtaatcaaa tttgtagaag taggcggatt tgcgaacaat    960

gaccttgtag aacagaagac acagttcttt gacggtggag taaatgttgg agatacaaca   1020

gaacctgcaa cacctacaac acctgtaaca acaccgacaa caacagatga tctggatgca   1080

ctcgagatca tcccagttga ggaggagaac ccggacttct ggaaccgcga ggcagccgag   1140

gccctgggtg ccgccaagaa gctgcagcct gcacagacag ccgccaagaa cctcatcatc   1200

ttcctgggcg atgggatggg ggtgtctacg gtgacagctg ccaggatcct aaaagggcag   1260

aagaaggaca aactggggcc tgagttaccc ctggccatgg accgcttccc atatgtggct   1320

ctgtccaaga catacaatgt agacaaacat gtgccagaca gtggagccac agccacggcc   1380

tacctgtgcg gggtcaaggg caacttccag accattggct tgagtgcagc cgcccgcttt   1440

aaccagtgca acacgacacg cggcaacgag gtcatctccg tgatgaatcg ggccaagaaa   1500

gcagggaagt cagtgggagt ggtaaccacc acacgagtgc agcacgcctc gccagccggc   1560

acctacgccc acacggtgaa ccgcaactgg tactcggacg ccgacgtgcc tgcctcggcc   1620

cgccaggagg ggtgccagga catcgctacg cagctcatct ccaacatgga cattgacgtg   1680

atcctaggtg gaggccgaaa gtacatgttt cgcatgggaa ccccagaccc tgagtaccca   1740

gatgactaca gccaaggtgg gaccaggctg gacgggaaga atctggtgca ggaatggctg   1800

gcgaagcgcc agggtgcccg gtacgtgtgg aaccgcactg agctcatgca ggcttccctg   1860

gacccgtctg tgacccatct catgggtctc tttgagcctg gagacatgaa atacgagatc   1920

caccgagact ccacactgga cccctccctg atggagatga cagaggctgc cctgcgcctg   1980

ctgagcagga acccccgcgg cttcttcctc ttcgtggagg gtggtcgcat cgaccatggt   2040

catcatgaaa gcagggctta ccgggcactg actgagacga tcatgttcga cgacgccatt   2100

gagagggcgg gccagctcac cagcgaggag gacacgctga gcctcgtcac tgccgaccac   2160

tcccacgtct tctccttcgg aggctacccc ctgcgaggga gctccatctt cgggctggcc   2220

cctggcaagg cccgggacag gaaggcctac acggtcctcc tatacggaaa cggtccaggc   2280

tatgtgctca aggacggcgc ccggccggat gttaccgaga gcgagagcgg gagccccgag   2340

tatcggcagc agtcagcagt gcccctggac gaagagaccc acgcaggcga ggacgtggcg   2400

gtgttcgcgc gcggcccgca ggcgcacctg gttcacggcg tgcaggagca gaccttcata   2460

gcgcacgtca tggccttcgc cgcctgcctg gagccctaca ccgcctgcga cctggcgccc   2520

cccgccggca ccacccacca tcaccatcac cattga                             2556


<210>  17
<211>  826
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  17

Leu Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys 
1               5                   10                  15      


Pro Gly Asp Thr Val Arg Ile Pro Val Arg Phe Ser Gly Ile Pro Ser 
            20                  25                  30          


Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val 
        35                  40                  45              


Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro Asn 
    50                  55                  60                  


Pro Asp Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Ile Ile 
65                  70                  75                  80  


Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr 
                85                  90                  95      


Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Ser Gly Ala 
            100                 105                 110         


Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala 
        115                 120                 125             


Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val 
    130                 135                 140                 


Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr 
145                 150                 155                 160 


Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Val Arg Ile Lys Val Asp 
                165                 170                 175     


Thr Val Asn Ala Lys Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe 
            180                 185                 190         


Ser Gly Ile Pro Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser 
        195                 200                 205             


Tyr Asp Pro Asn Val Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu 
    210                 215                 220                 


Ile Val Asp Pro Asn Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro 
225                 230                 235                 240 


Asp Arg Lys Met Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly 
                245                 250                 255     


Ala Tyr Ala Ile Thr Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys 
            260                 265                 270         


Val Lys Glu Gly Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu 
        275                 280                 285             


Val Gly Gly Phe Ala Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe 
    290                 295                 300                 


Phe Asp Gly Gly Val Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro 
305                 310                 315                 320 


Thr Thr Pro Val Thr Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Leu 
                325                 330                 335     


Glu Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            340                 345                 350         


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        355                 360                 365             


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    370                 375                 380                 


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
385                 390                 395                 400 


Gly Pro Glu Leu Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                405                 410                 415     


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            420                 425                 430         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        435                 440                 445             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    450                 455                 460                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
465                 470                 475                 480 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                485                 490                 495     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            500                 505                 510         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        515                 520                 525             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    530                 535                 540                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
545                 550                 555                 560 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                565                 570                 575     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            580                 585                 590         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        595                 600                 605             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    610                 615                 620                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
625                 630                 635                 640 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                645                 650                 655     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            660                 665                 670         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        675                 680                 685             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    690                 695                 700                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
705                 710                 715                 720 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                725                 730                 735     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            740                 745                 750         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        755                 760                 765             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    770                 775                 780                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
785                 790                 795                 800 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                805                 810                 815     


Ala Gly Thr Thr His His His His His His 
            820                 825     


<210>  18
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  18
atggatccca aaggatccct ttcctggaga atacttctgt ttctctccct ggcttttgag     60

ttgagctacg gactcgacga tctggatgca gtaaggatta aagtggacac agtaaatgca    120

aaaccgggag acacagtaag aatacctgta agattcagcg gtataccatc caagggaata    180

gcaaactgtg actttgtata cagctatgac ccgaatgtac ttgagataat agagatagaa    240

ccgggagaca taatagttga cccgaatcct gacaagagct ttgatactgc agtatatcct    300

gacagaaaga taatagtatt cctgtttgca gaagacagcg gaacaggagc gtatgcaata    360

actaaagacg gagtatttgc tacgatagta gcgaaagtaa aagaaggagc acctaacgga    420

ctcagtgtaa tcaaatttgt agaagtaggc ggatttgcga acaatgacct tgtagaacag    480

aagacacagt tctttgacgg tggagtaaat gttggagata caacagaacc tgcaacacct    540

acaacacctg taacaacacc gacaacaaca gatgatctgg atgcactcga ggcgcccctc    600

atcctgtctc ggattgtggg aggctgggag tgcgagaagc attcccaacc ctggcaggtg    660

cttgtggcct ctcgtggcag ggcagtctgc ggcggtgttc tggtgcaccc ccagtgggtc    720

ctcacagctg cccactgcat caggaacaaa agcgtgatct tgctgggtcg gcacagcctg    780

tttcatcctg aagacacagg ccaggtattt caggtcagcc acagcttccc acacccgctc    840

tacgatatga gcctcctgaa gaatcgattc ctcaggccag gtgatgactc cagccacgac    900

ctcatgctgc tccgcctgtc agagcctgcc gagctcacgg atgctgtgaa ggtcatggac    960

ctgcccaccc aggagccagc actggggacc acctgctacg cctcaggctg gggcagcatt   1020

gaaccagagg agttcttgac cccaaagaaa cttcagtgtg tggacctcca tgttatttcc   1080

aatgacgtgt gcgcgcaagt tcaccctcag aaggtgacca agttcatgct gtgtgctgga   1140

cgctggacag ggggcaaaag cacctgctcg ggtgattctg ggggcccact tgtctgtaat   1200

ggtgtgcttc aaggtatcac gtcatggggc agtgaaccat gtgccctgcc cgaaaggcct   1260

tccctgtaca ccaaggtggt gcattaccgg aagtggatca aggacaccat cgtggccaac   1320

ccctga                                                              1326


<210>  19
<211>  417
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  19

Leu Asp Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala 
1               5                   10                  15      


Lys Pro Gly Asp Thr Val Arg Ile Pro Val Arg Phe Ser Gly Ile Pro 
            20                  25                  30          


Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn 
        35                  40                  45              


Val Leu Glu Ile Ile Glu Ile Glu Pro Gly Glu Leu Ile Val Asp Pro 
    50                  55                  60                  


Asn Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met 
65                  70                  75                  80  


Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile 
                85                  90                  95      


Thr Glu Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Ser Gly 
            100                 105                 110         


Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe 
        115                 120                 125             


Ala Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly 
    130                 135                 140                 


Val Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val 
145                 150                 155                 160 


Thr Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Leu Glu Ala Pro Leu 
                165                 170                 175     


Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu Lys His Ser Gln 
            180                 185                 190         


Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly Gly 
        195                 200                 205             


Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg 
    210                 215                 220                 


Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu 
225                 230                 235                 240 


Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu 
                245                 250                 255     


Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp 
            260                 265                 270         


Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu 
        275                 280                 285             


Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu 
    290                 295                 300                 


Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu 
305                 310                 315                 320 


Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser 
                325                 330                 335     


Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met 
            340                 345                 350         


Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp 
        355                 360                 365             


Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser 
    370                 375                 380                 


Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr 
385                 390                 395                 400 


Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn 
                405                 410                 415     


Pro 
    


<210>  20
<211>  1554
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  20
atggatccca aaggatccct ttcctggaga atacttctgt ttctctccct ggcttttgag     60

ttgagctacg gactcgacga tctggatgca gtaaggatta aagtggacac agtaaatgca    120

aaaccgggag acacagtaag aatacctgta agattcagcg gtataccatc caagggaata    180

gcaaactgtg actttgtata cagctatgac ccgaatgtac ttgagataat agagatagaa    240

ccgggagaca taatagttga cccgaatcct gacaagagct ttgatactgc agtatatcct    300

gacagaaaga taatagtatt cctgtttgca gaagacagcg gaacaggagc gtatgcaata    360

actaaagacg gagtatttgc tacgatagta gcgaaagtaa aagaaggagc acctaacgga    420

ctcagtgtaa tcaaatttgt agaagtaggc ggatttgcga acaatgacct tgtagaacag    480

aagacacagt tctttgacgg tggagtaaat gttggagata caacagaacc tgcaacacct    540

acaacacctg taacaacacc gacaacaaca gatgatctgg atgcactcga ggatcagatt    600

tgcattggtt accatgcaaa caactcgaca gagcaggttg acacaataat ggaaaagaac    660

gttactgtta cacatgccca agacatactg gaaaagaaac acaacgggaa gctctgcgat    720

ctagatggag tgaagcctct aattttgaga gattgtagcg tagctggatg gctcctcgga    780

aacccaatgt gtgacgaatt catcaatgtg ccggaatggt cttacatagt ggagaaggcc    840

aatccagtca atgacctctg ttacccaggg gatttcaatg actatgaaaa attgaaacac    900

ctattgagca gaataaacca ttttgagaaa attcagatca tccccaaaag ttcttggtcc    960

agtcatgaag cctcattagg ggtgagctca gcatgtccat accagggaaa gtcctccttt   1020

ttcagaaatg tggtatggct tatcaaaaag aacagtacat acccaacaat aaagaggagc   1080

tacaataata ccaaccaaga agatcttttg gtactgtggg ggattcacca tcctaatgat   1140

gcggcagagc agacaaagct ctatcaaaac ccaaccacct atatttccgt tgggacatca   1200

acactaaacc agagattggt accaagaata gctactagat ccaaagtaaa cgggcaaagt   1260

ggaaggatgg agttcttctg gacaatttta aagccgaatg atgcaatcaa cttcgagagt   1320

aatggaaatt tcattgctcc agaatatgca tacaaaattg tcaagaaagg ggactcaaca   1380

attatgaaaa gtgaattgga atatggtaac tgcaacacca agtgtcaaac tccaatgggg   1440

gcgataaact ctagcatgcc attccacaat atacaccctc tcaccattgg ggaatgcccc   1500

aaatatgtga aatcaaacag attagtcctt gcgcaccatc accatcacca ttga         1554


<210>  21
<211>  493
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  21

Leu Asp Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala 
1               5                   10                  15      


Lys Pro Gly Asp Thr Val Arg Ile Pro Val Arg Phe Ser Gly Ile Pro 
            20                  25                  30          


Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn 
        35                  40                  45              


Val Leu Glu Ile Ile Glu Ile Glu Pro Gly Glu Leu Ile Val Asp Pro 
    50                  55                  60                  


Asn Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met 
65                  70                  75                  80  


Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile 
                85                  90                  95      


Thr Glu Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Ser Gly 
            100                 105                 110         


Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe 
        115                 120                 125             


Ala Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly 
    130                 135                 140                 


Val Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val 
145                 150                 155                 160 


Thr Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Leu Glu Asp Gln Ile 
                165                 170                 175     


Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile 
            180                 185                 190         


Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys 
        195                 200                 205             


Lys His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile 
    210                 215                 220                 


Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys 
225                 230                 235                 240 


Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala 
                245                 250                 255     


Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp Tyr Glu 
            260                 265                 270         


Lys Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 
        275                 280                 285             


Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser Leu Gly Val 
    290                 295                 300                 


Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe Arg Asn Val 
305                 310                 315                 320 


Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile Lys Arg Ser 
                325                 330                 335     


Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His 
            340                 345                 350         


His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr 
        355                 360                 365             


Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro 
    370                 375                 380                 


Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 
385                 390                 395                 400 


Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser 
                405                 410                 415     


Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys 
            420                 425                 430         


Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn 
        435                 440                 445             


Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe 
    450                 455                 460                 


His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys 
465                 470                 475                 480 


Ser Asn Arg Leu Val Leu Ala His His His His His His 
                485                 490             


<210>  22
<211>  1293
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  22
atggatctgg atgcagtaag gattaaagtg gacacagtaa atgcaaaacc gggagacaca     60

gtaaatatac ctgtaagatt cagtggtata ccatccaagg gaatagcaaa ctgtgacttt    120

gtatacagct atgacccgaa tgtacttgag ataatagaga taaaaccggg agaattgata    180

gttgacccga atcctaccaa gagctttgat actgcagtat atcctgacag aaagatgata    240

gtattcctgt ttgcggaaga cagcggaaca ggagcgtatg caataactaa agacggagta    300

tttgctacga tagtagcgaa agtaaaagaa ggagcaccta acgggctcag tgtaatcaaa    360

tttgtagaag taggcggatt tgcgaacaat gaccttgtag aacagaagac acagttcttt    420

gacggtggag taaatgttgg agatacaaca gaacctgcaa cacctacaac acctgtaaca    480

acaccgacaa caacagatga tctggatgca gctagccttc taaccgaggt cgaaacgtac    540

gttctctcta tcatcccgtc aggccccctc aaagccgaga tcgcacagag acttgaagat    600

gtctttgcag ggaagaacac cgatcttgag gttctcatgg aatggctaaa gacaagacca    660

atcctgtcac ctctgactaa ggggatttta ggatttgtgt tcacgctcac cgtgcccagt    720

gagcggggac tgcagcgtag acgctttgtc caaaatgctc ttaatgggaa cggagatcca    780

aataacatgg acaaagcagt taaactgtat aggaagctta agagggagat aacattccat    840

ggggccaaag aaatagcact cagttattct gctggtgcac ttgccagttg tatgggcctc    900

atatacaaca ggatgggggc tgtgaccact gaagtggcat ttggcctggt atgcgcaacc    960

tgtgaacaga ttgctgactc ccagcatcgg tctcataggc aaatggtgac aacaaccaat   1020

ccactaatca gacatgagaa cagaatggtt ctagccagca ctacagctaa ggctatggag   1080

caaatggctg gatcgagtga gcaagcagca gaggccatgg atattgctag tcaggccagg   1140

caaatggtgc aggcgatgag aaccattggg actcatccta gctccagtgc tggtctaaaa   1200

gatgatcttc ttgaaaattt gcaggcttac cagaaacgga tgggggtgca gatgcagcga   1260

ttcaagctcg agcaccacca ccaccaccac tga                                1293


<210>  23
<211>  430
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  23

Met Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys 
1               5                   10                  15      


Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly Ile Pro Ser 
            20                  25                  30          


Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val 
        35                  40                  45              


Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro Asn 
    50                  55                  60                  


Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met Ile 
65                  70                  75                  80  


Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr 
                85                  90                  95      


Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly Ala 
            100                 105                 110         


Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala 
        115                 120                 125             


Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val 
    130                 135                 140                 


Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr 
145                 150                 155                 160 


Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Ala Ser Leu Leu Thr Glu 
                165                 170                 175     


Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala 
            180                 185                 190         


Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn Thr Asp 
        195                 200                 205             


Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro 
    210                 215                 220                 


Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser 
225                 230                 235                 240 


Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu Asn Gly 
                245                 250                 255     


Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr Arg Lys 
            260                 265                 270         


Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ala Leu Ser 
        275                 280                 285             


Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg 
    290                 295                 300                 


Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys Ala Thr 
305                 310                 315                 320 


Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln Met Val 
                325                 330                 335     


Thr Thr Thr Asn Pro Leu Ile Arg His Glu Asn Arg Met Val Leu Ala 
            340                 345                 350         


Ser Thr Thr Ala Lys Ala Met Glu Gln Met Ala Gly Ser Ser Glu Gln 
        355                 360                 365             


Ala Ala Glu Ala Met Asp Ile Ala Ser Gln Ala Arg Gln Met Val Gln 
    370                 375                 380                 


Ala Met Arg Thr Ile Gly Thr His Pro Ser Ser Ser Ala Gly Leu Lys 
385                 390                 395                 400 


Asp Asp Leu Leu Glu Asn Leu Gln Ala Tyr Gln Lys Arg Met Gly Val 
                405                 410                 415     


Gln Met Gln Arg Phe Lys Leu Glu His His His His His His 
            420                 425                 430 


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  24

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  25
<211>  661
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  25

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  26

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  27

Ile Met Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  28

Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  29

Tyr Leu Glu Pro Gly Pro Val Thr Val 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  30

Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210>  31
<211>  204
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  31

Met Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys 
1               5                   10                  15      


Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly Ile Pro Ser 
            20                  25                  30          


Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val 
        35                  40                  45              


Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro Asn 
    50                  55                  60                  


Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met Ile 
65                  70                  75                  80  


Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr 
                85                  90                  95      


Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly Ala 
            100                 105                 110         


Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala 
        115                 120                 125             


Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val 
    130                 135                 140                 


Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr 
145                 150                 155                 160 


Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Ala Arg Ser Ala Phe Thr 
                165                 170                 175     


Ile Met Asp Gln Val Pro Phe Ser Val Ser Val Ser Ala Ser Arg Lys 
            180                 185                 190         


Gly Ala Ala Ala Leu Glu His His His His His His 
        195                 200                 


<210>  32
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  32

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  33
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  33

Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  34

Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  35

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  36
<211>  204
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  36

Met Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys 
1               5                   10                  15      


Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly Ile Pro Ser 
            20                  25                  30          


Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val 
        35                  40                  45              


Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro Asn 
    50                  55                  60                  


Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met Ile 
65                  70                  75                  80  


Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr 
                85                  90                  95      


Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly Ala 
            100                 105                 110         


Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala 
        115                 120                 125             


Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val 
    130                 135                 140                 


Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr 
145                 150                 155                 160 


Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Ala Arg Thr Ala Glu Glu 
                165                 170                 175     


Leu Ala Gly Ile Gly Ile Leu Thr Val Ile Leu Gly Ala Ser Arg Lys 
            180                 185                 190         


Gly Ala Ala Ala Leu Glu His His His His His His 
        195                 200                 


<210>  37
<211>  241
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  37

Met Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys 
1               5                   10                  15      


Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly Ile Pro Ser 
            20                  25                  30          


Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val 
        35                  40                  45              


Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro Asn 
    50                  55                  60                  


Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met Ile 
65                  70                  75                  80  


Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr 
                85                  90                  95      


Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly Ala 
            100                 105                 110         


Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala 
        115                 120                 125             


Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val 
    130                 135                 140                 


Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr 
145                 150                 155                 160 


Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Ala Ser Asp Thr Thr Glu 
                165                 170                 175     


Ala Arg His Pro His Pro Pro Val Thr Thr Pro Thr Thr Asp Arg Lys 
            180                 185                 190         


Gly Thr Thr Ala Glu Glu Leu Ala Gly Ile Gly Ile Leu Thr Val Ile 
        195                 200                 205             


Leu Gly Gly Lys Arg Thr Asn Asn Ser Thr Pro Thr Lys Gly Glu Phe 
    210                 215                 220                 


Cys Arg Tyr Pro Ser His Trp Arg Pro Leu Glu His His His His His 
225                 230                 235                 240 


His 
    


<210>  38
<211>  66
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  38

Ala Ser Asp Thr Thr Glu Ala Arg His Pro His Pro Pro Val Thr Thr 
1               5                   10                  15      


Pro Thr Thr Thr Asp Arg Lys Gly Thr Thr Ala Glu Glu Leu Ala Gly 
            20                  25                  30          


Ile Gly Ile Leu Thr Val Ile Leu Gly Gly Lys Arg Thr Asn Asn Ser 
        35                  40                  45              


Thr Pro Thr Lys Gly Glu Phe Cys Arg Tyr Pro Ser His Trp Arg Pro 
    50                  55                  60                  


Arg Leu 
65      


<210>  39
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  39
cacggtcacc gtctccaaag cttccggagc tagcgagggc ggcagcctgg ccgcgct        57


<210>  40
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized oligonucleotide

<400>  40
ggccggctcc tgcgaaggga gccggccggt cgcggccgct tacttcaggt cctcgcgcgg     60

cggtttgccg                                                            70


<210>  41
<211>  518
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  41

Met Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala Lys 
1               5                   10                  15      


Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly Ile Pro Ser 
            20                  25                  30          


Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn Val 
        35                  40                  45              


Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro Asn 
    50                  55                  60                  


Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met Ile 
65                  70                  75                  80  


Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile Thr 
                85                  90                  95      


Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly Ala 
            100                 105                 110         


Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe Ala 
        115                 120                 125             


Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly Val 
    130                 135                 140                 


Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr 
145                 150                 155                 160 


Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Ala Ser Glu Gly Gly Ser 
                165                 170                 175     


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
            180                 185                 190         


Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys 
        195                 200                 205             


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
    210                 215                 220                 


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
225                 230                 235                 240 


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
                245                 250                 255     


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
            260                 265                 270         


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala 
        275                 280                 285             


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
    290                 295                 300                 


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
305                 310                 315                 320 


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
                325                 330                 335     


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
            340                 345                 350         


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
        355                 360                 365             


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
    370                 375                 380                 


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
385                 390                 395                 400 


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
                405                 410                 415     


Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
            420                 425                 430         


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
        435                 440                 445             


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
    450                 455                 460                 


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
465                 470                 475                 480 


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
                485                 490                 495     


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
            500                 505                 510         


Pro Arg Glu Asp Leu Lys 
        515             


<210>  42
<211>  614
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  42

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Phe Arg Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Gly Ser Ser Ala Lys Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser 
        435                 440                 445             


Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Pro Thr Thr 
    450                 455                 460                 


Thr Asp Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala 
465                 470                 475                 480 


Lys Pro Gly Asp Thr Val Asn Ile Pro Val Arg Phe Ser Gly Ile Pro 
                485                 490                 495     


Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn 
            500                 505                 510         


Val Leu Glu Ile Ile Glu Ile Lys Pro Gly Glu Leu Ile Val Asp Pro 
        515                 520                 525             


Asn Pro Thr Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Met 
    530                 535                 540                 


Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile 
545                 550                 555                 560 


Thr Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly 
                565                 570                 575     


Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe 
            580                 585                 590         


Ala Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly 
        595                 600                 605             


Val Asn Val Gly Asp Thr 
    610                 


<210>  43
<211>  308
<212>  PRT
<213>  Artificial

<220>
<223>  Chemically synthesized peptide

<400>  43

Leu Asp Asp Leu Asp Ala Val Arg Ile Lys Val Asp Thr Val Asn Ala 
1               5                   10                  15      


Lys Pro Gly Asp Thr Val Arg Ile Pro Val Arg Phe Ser Gly Ile Pro 
            20                  25                  30          


Ser Lys Gly Ile Ala Asn Cys Asp Phe Val Tyr Ser Tyr Asp Pro Asn 
        35                  40                  45              


Val Leu Glu Ile Ile Glu Ile Glu Pro Gly Asp Ile Ile Val Asp Pro 
    50                  55                  60                  


Asn Pro Asp Lys Ser Phe Asp Thr Ala Val Tyr Pro Asp Arg Lys Ile 
65                  70                  75                  80  


Ile Val Phe Leu Phe Ala Glu Asp Ser Gly Thr Gly Ala Tyr Ala Ile 
                85                  90                  95      


Thr Lys Asp Gly Val Phe Ala Thr Ile Val Ala Lys Val Lys Glu Gly 
            100                 105                 110         


Ala Pro Asn Gly Leu Ser Val Ile Lys Phe Val Glu Val Gly Gly Phe 
        115                 120                 125             


Ala Asn Asn Asp Leu Val Glu Gln Lys Thr Gln Phe Phe Asp Gly Gly 
    130                 135                 140                 


Val Asn Val Gly Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val 
145                 150                 155                 160 


Thr Thr Pro Thr Thr Thr Asp Asp Leu Asp Ala Leu Glu Ala Asp Gln 
                165                 170                 175     


Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val 
            180                 185                 190         


Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro 
        195                 200                 205             


Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys 
    210                 215                 220                 


Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg 
225                 230                 235                 240 


Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr 
                245                 250                 255     


Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp 
            260                 265                 270         


Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser 
        275                 280                 285             


Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly 
    290                 295                 300                 


Ser Glu Asp Ser 
305             


