                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado
       Graham, Douglas
       Sather, Susan
 
<120>  AXL TYROSINE KINASE INHIBITORS AND METHODS OF MAKING AND USING 
       THE SAME

<130>  2848-95-PCT

<150>  60/888,741
<151>  2007-02-07

<160>  18    

<170>  PatentIn version 3.4

<210>  1
<211>  5014
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (459)..(3143)

<400>  1
gagtggagtt ctggaggaat gtttaccaga cacagagccc agagggacag cgcccagagc     60

ccagatagag agacacggcc tcactggctc agcaccaggg tccccttccc cctcctcagc    120

tccctccctg gcccctttaa gaaagagctg atcctctcct ctcttgagtt aacccctgat    180

tgtccaggtg gcccctggct ctggcctggt gggcggaggc aaagggggag ccaggggcgg    240

agaaagggtt gcccaagtct gggagtgagg gaaggaggca ggggtgctga gaaggcggct    300

gctgggcaga gccggtggca agggcctccc ctgccgctgt gccaggcagg cagtgccaaa    360

tccggggagc ctggagctgg ggggagggcc ggggacagcc cggccctgcc ccctcccccg    420

ctgggagccc agcaacttct gaggaaagtt tggcaccc atg gcg tgg cgg tgc ccc    476
                                          Met Ala Trp Arg Cys Pro       
                                          1               5             

agg atg ggc agg gtc ccg ctg gcc tgg tgc ttg gcg ctg tgc ggc tgg      524
Arg Met Gly Arg Val Pro Leu Ala Trp Cys Leu Ala Leu Cys Gly Trp         
            10                  15                  20                  

gcg tgc atg gcc ccc agg ggc acg cag gct gaa gaa agt ccc ttc gtg      572
Ala Cys Met Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val         
        25                  30                  35                      

ggc aac cca ggg aat atc aca ggt gcc cgg gga ctc acg ggc acc ctt      620
Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu         
    40                  45                  50                          

cgg tgt cag ctc cag gtt cag gga gag ccc ccc gag gta cat tgg ctt      668
Arg Cys Gln Leu Gln Val Gln Gly Glu Pro Pro Glu Val His Trp Leu         
55                  60                  65                  70          

cgg gat gga cag atc ctg gag ctc gcg gac agc acc cag acc cag gtg      716
Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val         
                75                  80                  85              

ccc ctg ggt gag gat gaa cag gat gac tgg ata gtg gtc agc cag ctc      764
Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser Gln Leu         
            90                  95                  100                 

aga atc acc tcc ctg cag ctt tcc gac acg gga cag tac cag tgt ttg      812
Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln Cys Leu         
        105                 110                 115                     

gtg ttt ctg gga cat cag acc ttc gtg tcc cag cct ggc tat gtt ggg      860
Val Phe Leu Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr Val Gly         
    120                 125                 130                         

ctg gag ggc ttg cct tac ttc ctg gag gag ccc gaa gac agg act gtg      908
Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val         
135                 140                 145                 150         

gcc gcc aac acc ccc ttc aac ctg agc tgc caa gct cag gga ccc cca      956
Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro         
                155                 160                 165             

gag ccc gtg gac cta ctc tgg ctc cag gat gct gtc ccc ctg gcc acg     1004
Glu Pro Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr         
            170                 175                 180                 

gct cca ggt cac ggc ccc cag cgc agc ctg cat gtt cca ggg ctg aac     1052
Ala Pro Gly His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn         
        185                 190                 195                     

aag aca tcc tct ttc tcc tgc gaa gcc cat aac gcc aag ggg gtc acc     1100
Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr         
    200                 205                 210                         

aca tcc cgc aca gcc acc atc aca gtg ctc ccc cag cag ccc cgt aac     1148
Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Gln Pro Arg Asn         
215                 220                 225                 230         

ctc cac ctg gtc tcc cgc caa ccc acg gag ctg gag gtg gct tgg act     1196
Leu His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr         
                235                 240                 245             

cca ggc ctg agc ggc atc tac ccc ctg acc cac tgc acc ctg cag gct     1244
Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala         
            250                 255                 260                 

gtg ctg tca gac gat ggg atg ggc atc cag gcg gga gaa cca gac ccc     1292
Val Leu Ser Asp Asp Gly Met Gly Ile Gln Ala Gly Glu Pro Asp Pro         
        265                 270                 275                     

cca gag gag ccc ctc acc tcg caa gca tcc gtg ccc ccc cat cag ctt     1340
Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser Val Pro Pro His Gln Leu         
    280                 285                 290                         

cgg cta ggc agc ctc cat cct cac acc cct tat cac atc cgc gtg gca     1388
Arg Leu Gly Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala         
295                 300                 305                 310         

tgc acc agc agc cag ggc ccc tca tcc tgg acc cac tgg ctt cct gtg     1436
Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr His Trp Leu Pro Val         
                315                 320                 325             

gag acg ccg gag gga gtg ccc ctg ggc ccc cct gag aac att agt gct     1484
Glu Thr Pro Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala         
            330                 335                 340                 

acg cgg aat ggg agc cag gcc ttc gtg cat tgg caa gag ccc cgg gcg     1532
Thr Arg Asn Gly Ser Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala         
        345                 350                 355                     

ccc ctg cag ggt acc ctg tta ggg tac cgg ctg gcg tat caa ggc cag     1580
Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln         
    360                 365                 370                         

gac acc cca gag gtg cta atg gac ata ggg cta agg caa gag gtg acc     1628
Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr         
375                 380                 385                 390         

ctg gag ctg cag ggg gac ggg tct gtg tcc aat ctg aca gtg tgt gtg     1676
Leu Glu Leu Gln Gly Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val         
                395                 400                 405             

gca gcc tac act gct gct ggg gat gga ccc tgg agc ctc cca gta ccc     1724
Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro         
            410                 415                 420                 

ctg gag gcc tgg cgc cca ggg caa gca cag cca gtc cac cag ctg gtg     1772
Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln Pro Val His Gln Leu Val         
        425                 430                 435                     

aag gaa cct tca act cct gcc ttc tcg tgg ccc tgg tgg tat gta ctg     1820
Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu         
    440                 445                 450                         

cta gga gca gtc gtg gcc gct gcc tgt gtc ctc atc ttg gct ctc ttc     1868
Leu Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe         
455                 460                 465                 470         

ctt gtc cac cgg cga aag aag gag acc cgt tat gga gaa gtg ttt gaa     1916
Leu Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu         
                475                 480                 485             

cca aca gtg gaa aga ggt gaa ctg gta gtc agg tac cgc gtg cgc aag     1964
Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys         
            490                 495                 500                 

tcc tac agt cgt cgg acc act gaa gct acc ttg aac agc ctg ggc atc     2012
Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile         
        505                 510                 515                     

agt gaa gag ctg aag gag aag ctg cgg gat gtg atg gtg gac cgg cac     2060
Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His         
    520                 525                 530                         

aag gtg gcc ctg ggg aag act ctg gga gag gga gag ttt gga gct gtg     2108
Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val         
535                 540                 545                 550         

atg gaa ggc cag ctc aac cag gac gac tcc atc ctc aag gtg gct gtg     2156
Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val         
                555                 560                 565             

aag acg atg aag att gcc atc tgc acg agg tca gag ctg gag gat ttc     2204
Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe         
            570                 575                 580                 

ctg agt gaa gcg gtc tgc atg aag gaa ttt gac cat ccc aac gtc atg     2252
Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met         
        585                 590                 595                     

agg ctc atc ggt gtc tgt ttc cag ggt tct gaa cga gag agc ttc cca     2300
Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro         
    600                 605                 610                         

gca cct gtg gtc atc tta cct ttc atg aaa cat gga gac cta cac agc     2348
Ala Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser         
615                 620                 625                 630         

ttc ctc ctc tat tcc cgg ctc ggg gac cag cca gtg tac ctg ccc act     2396
Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr         
                635                 640                 645             

cag atg cta gtg aag ttc atg gca gac atc gcc agt ggc atg gag tat     2444
Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr         
            650                 655                 660                 

ctg agt acc aag aga ttc ata cac cgg gac ctg gcg gcc agg aac tgc     2492
Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys         
        665                 670                 675                     

atg ctg aat gag aac atg tcc gtg tgt gtg gcg gac ttc ggg ctc tcc     2540
Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser         
    680                 685                 690                         

aag aag atc tac aat ggg gac tac tac cgc cag gga cgt atc gcc aag     2588
Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys         
695                 700                 705                 710         

atg cca gtc aag tgg att gcc att gag agt cta gct gac cgt gtc tac     2636
Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr         
                715                 720                 725             

acc agc aag agc gat gtg tgg tcc ttc ggg gtg aca atg tgg gag att     2684
Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile         
            730                 735                 740                 

gcc aca aga ggc caa acc cca tat ccg ggc gtg gag aac agc gag att     2732
Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile         
        745                 750                 755                     

tat gac tat ctg cgc cag gga aat cgc ctg aag cag cct gcg gac tgt     2780
Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys         
    760                 765                 770                         

ctg gat gga ctg tat gcc ttg atg tcg cgg tgc tgg gag cta aat ccc     2828
Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro         
775                 780                 785                 790         

cag gac cgg cca agt ttt aca gag ctg cgg gaa gat ttg gag aac aca     2876
Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr         
                795                 800                 805             

ctg aag gcc ttg cct cct gcc cag gag cct gac gaa atc ctc tat gtc     2924
Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val         
            810                 815                 820                 

aac atg gat gag ggt gga ggt tat cct gaa ccc cct gga gct gca gga     2972
Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly         
        825                 830                 835                     

gga gct gac ccc cca acc cag cca gac cct aag gat tcc tgt agc tgc     3020
Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys         
    840                 845                 850                         

ctc act gcg gct gag gtc cat cct gct gga cgc tat gtc ctc tgc cct     3068
Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro         
855                 860                 865                 870         

tcc aca acc cct agc ccc gct cag cct gct gat agg ggc tcc cca gca     3116
Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala         
                875                 880                 885             

gcc cca ggg cag gag gat ggt gcc tga gacaaccctc cacctggtac           3163
Ala Pro Gly Gln Glu Asp Gly Ala                                         
            890                                                         

tccctctcag gatccaagct aagcactgcc actggggaaa actccacctt cccactttcc   3223

caccccacgc cttatcccca cttgcagccc tgtcttccta cctatcccac ctccatccca   3283

gacaggtccc tccccttctc tgtgcagtag catcaccttg aaagcagtag catcaccatc   3343

tgtaaaagga aggggttgga ttgcaatatc tgaagccctc ccaggtgtta acattccaag   3403

actctagagt ccaaggttta aagagtctag attcaaaggt tctaggtttc aaagatgctg   3463

tgagtctttg gttctaagga cctgaaattc caaagtctct aattctatta aagtgctaag   3523

gttctaaggc ctactttttt tttttttttt tttttttttt ttttttttgc gatagagtct   3583

cactgtgtca cccaggctgg agtgcagtgg tgcaatctcg cctcactgca accttcacct   3643

accgagttca agtgattttc ctgccttggc ctcccaagta gctgggatta caggtgtgtg   3703

ccaccacacc cggctaattt ttatattttt agtagagaca gggtttcacc atgttggcca   3763

ggctggtcta aaactcctga cctcaagtga tctgcccacc tcagcctccc aaagtgctga   3823

gattacaggc atgagccact gcactcaacc ttaagaccta ctgttctaaa gctctgacat   3883

tatgtggttt tagattttct ggttctaaca tttttgataa agcctcaagg ttttaggttc   3943

taaagttcta agattctgat tttaggagct aaggctctat gagtctagat gtttattctt   4003

ctagagttca gagtccttaa aatgtaagat tatagattct aaagattcta tagttctaga   4063

catggaggtt ctaaggccta ggattctaaa atgtgatgtt ctaaggctct gagagtctag   4123

attctctggc tgtaaggctc tagatcataa ggcttcaaaa tgttatcttc tcaagttcta   4183

agattctaat gatgatcaat tatagtttct gaggctttat gataatagat tctcttgtat   4243

aagatcctag atcctaaggg tcgaaagctc tagaatctgc aattcaaaag ttccaagagt   4303

ctaaagatgg agtttctaag gtccggtgtt ctaagatgtg atattctaag acttactcta   4363

agatcttaga ttctctgtgt ctaagattct agatcagatg ctccaagatt ctagatgatt   4423

aaataagatt ctaacggtct gttctgtttc aaggcactct agattccatt ggtccaagat   4483

tccggatcct aagcatctaa gttataagac tctcacactc agttgtgact aactagacac   4543

caaagttcta ataatttcta atgttggaca cctttaggtt ctttgctgca ttctgcctct   4603

ctaggaccat ggttaagagt ccaagaatcc acatttctaa aatcttatag ttctaggcac   4663

tgtagttcta agactcaaat gttctaagtt tctaagattc taaaggtcca caggtctaga   4723

ctattaggtg caatttcaag gttctaaccc tatactgtag tattctttgg ggtgcccctc   4783

tccttcttag ctatcattgc ttcctcctcc ccaactgtgg gggtgtgccc ccttcaagcc   4843

tgtgcaatgc attagggatg cctcctttcc cgcaggggat ggacgatctc ccacctttcg   4903

ggccatgttg cccccgtgag ccaatccctc accttctgag tacagagtgt ggactctggt   4963

gcctccagag gggctcaggt cacataaaac tttgtatatc aacgaaaaaa a            5014


<210>  2
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  3
<211>  4987
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (459)..(3116)

<400>  3
gagtggagtt ctggaggaat gtttaccaga cacagagccc agagggacag cgcccagagc     60

ccagatagag agacacggcc tcactggctc agcaccaggg tccccttccc cctcctcagc    120

tccctccctg gcccctttaa gaaagagctg atcctctcct ctcttgagtt aacccctgat    180

tgtccaggtg gcccctggct ctggcctggt gggcggaggc aaagggggag ccaggggcgg    240

agaaagggtt gcccaagtct gggagtgagg gaaggaggca ggggtgctga gaaggcggct    300

gctgggcaga gccggtggca agggcctccc ctgccgctgt gccaggcagg cagtgccaaa    360

tccggggagc ctggagctgg ggggagggcc ggggacagcc cggccctgcc ccctcccccg    420

ctgggagccc agcaacttct gaggaaagtt tggcaccc atg gcg tgg cgg tgc ccc    476
                                          Met Ala Trp Arg Cys Pro       
                                          1               5             

agg atg ggc agg gtc ccg ctg gcc tgg tgc ttg gcg ctg tgc ggc tgg      524
Arg Met Gly Arg Val Pro Leu Ala Trp Cys Leu Ala Leu Cys Gly Trp         
            10                  15                  20                  

gcg tgc atg gcc ccc agg ggc acg cag gct gaa gaa agt ccc ttc gtg      572
Ala Cys Met Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val         
        25                  30                  35                      

ggc aac cca ggg aat atc aca ggt gcc cgg gga ctc acg ggc acc ctt      620
Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu         
    40                  45                  50                          

cgg tgt cag ctc cag gtt cag gga gag ccc ccc gag gta cat tgg ctt      668
Arg Cys Gln Leu Gln Val Gln Gly Glu Pro Pro Glu Val His Trp Leu         
55                  60                  65                  70          

cgg gat gga cag atc ctg gag ctc gcg gac agc acc cag acc cag gtg      716
Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val         
                75                  80                  85              

ccc ctg ggt gag gat gaa cag gat gac tgg ata gtg gtc agc cag ctc      764
Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser Gln Leu         
            90                  95                  100                 

aga atc acc tcc ctg cag ctt tcc gac acg gga cag tac cag tgt ttg      812
Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln Cys Leu         
        105                 110                 115                     

gtg ttt ctg gga cat cag acc ttc gtg tcc cag cct ggc tat gtt ggg      860
Val Phe Leu Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr Val Gly         
    120                 125                 130                         

ctg gag ggc ttg cct tac ttc ctg gag gag ccc gaa gac agg act gtg      908
Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val         
135                 140                 145                 150         

gcc gcc aac acc ccc ttc aac ctg agc tgc caa gct cag gga ccc cca      956
Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro         
                155                 160                 165             

gag ccc gtg gac cta ctc tgg ctc cag gat gct gtc ccc ctg gcc acg     1004
Glu Pro Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr         
            170                 175                 180                 

gct cca ggt cac ggc ccc cag cgc agc ctg cat gtt cca ggg ctg aac     1052
Ala Pro Gly His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn         
        185                 190                 195                     

aag aca tcc tct ttc tcc tgc gaa gcc cat aac gcc aag ggg gtc acc     1100
Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr         
    200                 205                 210                         

aca tcc cgc aca gcc acc atc aca gtg ctc ccc cag cag ccc cgt aac     1148
Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Gln Pro Arg Asn         
215                 220                 225                 230         

ctc cac ctg gtc tcc cgc caa ccc acg gag ctg gag gtg gct tgg act     1196
Leu His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr         
                235                 240                 245             

cca ggc ctg agc ggc atc tac ccc ctg acc cac tgc acc ctg cag gct     1244
Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala         
            250                 255                 260                 

gtg ctg tca gac gat ggg atg ggc atc cag gcg gga gaa cca gac ccc     1292
Val Leu Ser Asp Asp Gly Met Gly Ile Gln Ala Gly Glu Pro Asp Pro         
        265                 270                 275                     

cca gag gag ccc ctc acc tcg caa gca tcc gtg ccc ccc cat cag ctt     1340
Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser Val Pro Pro His Gln Leu         
    280                 285                 290                         

cgg cta ggc agc ctc cat cct cac acc cct tat cac atc cgc gtg gca     1388
Arg Leu Gly Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala         
295                 300                 305                 310         

tgc acc agc agc cag ggc ccc tca tcc tgg acc cac tgg ctt cct gtg     1436
Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr His Trp Leu Pro Val         
                315                 320                 325             

gag acg ccg gag gga gtg ccc ctg ggc ccc cct gag aac att agt gct     1484
Glu Thr Pro Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala         
            330                 335                 340                 

acg cgg aat ggg agc cag gcc ttc gtg cat tgg caa gag ccc cgg gcg     1532
Thr Arg Asn Gly Ser Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala         
        345                 350                 355                     

ccc ctg cag ggt acc ctg tta ggg tac cgg ctg gcg tat caa ggc cag     1580
Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln         
    360                 365                 370                         

gac acc cca gag gtg cta atg gac ata ggg cta agg caa gag gtg acc     1628
Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr         
375                 380                 385                 390         

ctg gag ctg cag ggg gac ggg tct gtg tcc aat ctg aca gtg tgt gtg     1676
Leu Glu Leu Gln Gly Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val         
                395                 400                 405             

gca gcc tac act gct gct ggg gat gga ccc tgg agc ctc cca gta ccc     1724
Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro         
            410                 415                 420                 

ctg gag gcc tgg cgc cca gtg aag gaa cct tca act cct gcc ttc tcg     1772
Leu Glu Ala Trp Arg Pro Val Lys Glu Pro Ser Thr Pro Ala Phe Ser         
        425                 430                 435                     

tgg ccc tgg tgg tat gta ctg cta gga gca gtc gtg gcc gct gcc tgt     1820
Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys         
    440                 445                 450                         

gtc ctc atc ttg gct ctc ttc ctt gtc cac cgg cga aag aag gag acc     1868
Val Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr         
455                 460                 465                 470         

cgt tat gga gaa gtg ttt gaa cca aca gtg gaa aga ggt gaa ctg gta     1916
Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val         
                475                 480                 485             

gtc agg tac cgc gtg cgc aag tcc tac agt cgt cgg acc act gaa gct     1964
Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala         
            490                 495                 500                 

acc ttg aac agc ctg ggc atc agt gaa gag ctg aag gag aag ctg cgg     2012
Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg         
        505                 510                 515                     

gat gtg atg gtg gac cgg cac aag gtg gcc ctg ggg aag act ctg gga     2060
Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly         
    520                 525                 530                         

gag gga gag ttt gga gct gtg atg gaa ggc cag ctc aac cag gac gac     2108
Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp         
535                 540                 545                 550         

tcc atc ctc aag gtg gct gtg aag acg atg aag att gcc atc tgc acg     2156
Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr         
                555                 560                 565             

agg tca gag ctg gag gat ttc ctg agt gaa gcg gtc tgc atg aag gaa     2204
Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu         
            570                 575                 580                 

ttt gac cat ccc aac gtc atg agg ctc atc ggt gtc tgt ttc cag ggt     2252
Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly         
        585                 590                 595                     

tct gaa cga gag agc ttc cca gca cct gtg gtc atc tta cct ttc atg     2300
Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met         
    600                 605                 610                         

aaa cat gga gac cta cac agc ttc ctc ctc tat tcc cgg ctc ggg gac     2348
Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp         
615                 620                 625                 630         

cag cca gtg tac ctg ccc act cag atg cta gtg aag ttc atg gca gac     2396
Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp         
                635                 640                 645             

atc gcc agt ggc atg gag tat ctg agt acc aag aga ttc ata cac cgg     2444
Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg         
            650                 655                 660                 

gac ctg gcg gcc agg aac tgc atg ctg aat gag aac atg tcc gtg tgt     2492
Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys         
        665                 670                 675                     

gtg gcg gac ttc ggg ctc tcc aag aag atc tac aat ggg gac tac tac     2540
Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr         
    680                 685                 690                         

cgc cag gga cgt atc gcc aag atg cca gtc aag tgg att gcc att gag     2588
Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu         
695                 700                 705                 710         

agt cta gct gac cgt gtc tac acc agc aag agc gat gtg tgg tcc ttc     2636
Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe         
                715                 720                 725             

ggg gtg aca atg tgg gag att gcc aca aga ggc caa acc cca tat ccg     2684
Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro         
            730                 735                 740                 

ggc gtg gag aac agc gag att tat gac tat ctg cgc cag gga aat cgc     2732
Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg         
        745                 750                 755                     

ctg aag cag cct gcg gac tgt ctg gat gga ctg tat gcc ttg atg tcg     2780
Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser         
    760                 765                 770                         

cgg tgc tgg gag cta aat ccc cag gac cgg cca agt ttt aca gag ctg     2828
Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu         
775                 780                 785                 790         

cgg gaa gat ttg gag aac aca ctg aag gcc ttg cct cct gcc cag gag     2876
Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu         
                795                 800                 805             

cct gac gaa atc ctc tat gtc aac atg gat gag ggt gga ggt tat cct     2924
Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro         
            810                 815                 820                 

gaa ccc cct gga gct gca gga gga gct gac ccc cca acc cag cca gac     2972
Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp         
        825                 830                 835                     

cct aag gat tcc tgt agc tgc ctc act gcg gct gag gtc cat cct gct     3020
Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala         
    840                 845                 850                         

gga cgc tat gtc ctc tgc cct tcc aca acc cct agc ccc gct cag cct     3068
Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro         
855                 860                 865                 870         

gct gat agg ggc tcc cca gca gcc cca ggg cag gag gat ggt gcc tga     3116
Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala             
                875                 880                 885             

gacaaccctc cacctggtac tccctctcag gatccaagct aagcactgcc actggggaaa   3176

actccacctt cccactttcc caccccacgc cttatcccca cttgcagccc tgtcttccta   3236

cctatcccac ctccatccca gacaggtccc tccccttctc tgtgcagtag catcaccttg   3296

aaagcagtag catcaccatc tgtaaaagga aggggttgga ttgcaatatc tgaagccctc   3356

ccaggtgtta acattccaag actctagagt ccaaggttta aagagtctag attcaaaggt   3416

tctaggtttc aaagatgctg tgagtctttg gttctaagga cctgaaattc caaagtctct   3476

aattctatta aagtgctaag gttctaaggc ctactttttt tttttttttt tttttttttt   3536

ttttttttgc gatagagtct cactgtgtca cccaggctgg agtgcagtgg tgcaatctcg   3596

cctcactgca accttcacct accgagttca agtgattttc ctgccttggc ctcccaagta   3656

gctgggatta caggtgtgtg ccaccacacc cggctaattt ttatattttt agtagagaca   3716

gggtttcacc atgttggcca ggctggtcta aaactcctga cctcaagtga tctgcccacc   3776

tcagcctccc aaagtgctga gattacaggc atgagccact gcactcaacc ttaagaccta   3836

ctgttctaaa gctctgacat tatgtggttt tagattttct ggttctaaca tttttgataa   3896

agcctcaagg ttttaggttc taaagttcta agattctgat tttaggagct aaggctctat   3956

gagtctagat gtttattctt ctagagttca gagtccttaa aatgtaagat tatagattct   4016

aaagattcta tagttctaga catggaggtt ctaaggccta ggattctaaa atgtgatgtt   4076

ctaaggctct gagagtctag attctctggc tgtaaggctc tagatcataa ggcttcaaaa   4136

tgttatcttc tcaagttcta agattctaat gatgatcaat tatagtttct gaggctttat   4196

gataatagat tctcttgtat aagatcctag atcctaaggg tcgaaagctc tagaatctgc   4256

aattcaaaag ttccaagagt ctaaagatgg agtttctaag gtccggtgtt ctaagatgtg   4316

atattctaag acttactcta agatcttaga ttctctgtgt ctaagattct agatcagatg   4376

ctccaagatt ctagatgatt aaataagatt ctaacggtct gttctgtttc aaggcactct   4436

agattccatt ggtccaagat tccggatcct aagcatctaa gttataagac tctcacactc   4496

agttgtgact aactagacac caaagttcta ataatttcta atgttggaca cctttaggtt   4556

ctttgctgca ttctgcctct ctaggaccat ggttaagagt ccaagaatcc acatttctaa   4616

aatcttatag ttctaggcac tgtagttcta agactcaaat gttctaagtt tctaagattc   4676

taaaggtcca caggtctaga ctattaggtg caatttcaag gttctaaccc tatactgtag   4736

tattctttgg ggtgcccctc tccttcttag ctatcattgc ttcctcctcc ccaactgtgg   4796

gggtgtgccc ccttcaagcc tgtgcaatgc attagggatg cctcctttcc cgcaggggat   4856

ggacgatctc ccacctttcg ggccatgttg cccccgtgag ccaatccctc accttctgag   4916

tacagagtgt ggactctggt gcctccagag gggctcaggt cacataaaac tttgtatatc   4976

aacgaaaaaa a                                                        4987


<210>  4
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  5
<211>  4200
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (144)..(2783)

<400>  5
ggaggagttg agccagccga ggggctcccg ctgtgccagg cgggcagtgc caaatcccag     60

gagccctgcc ccctttccta gcgaggtgcc catcaacttc ggaagaaagt ttggcatcaa    120

tctgagctgt tggtgtctgg agg atg ggc agg gtc ccg ctg gcc tgg tgg ttg    173
                          Met Gly Arg Val Pro Leu Ala Trp Trp Leu       
                          1               5                   10        

gcg ctg tgc tgc tgg ggg tgt gca gcc cat aag gac aca cag acc gag      221
Ala Leu Cys Cys Trp Gly Cys Ala Ala His Lys Asp Thr Gln Thr Glu         
                15                  20                  25              

gct ggc agc ccg ttt gtg ggg aac cca ggg aat atc aca ggt gcc aga      269
Ala Gly Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg         
            30                  35                  40                  

gga ctc acg ggg aca ctt cgg tgt gag ctc cag gtt cag ggg gaa ccc      317
Gly Leu Thr Gly Thr Leu Arg Cys Glu Leu Gln Val Gln Gly Glu Pro         
        45                  50                  55                      

cct gag gtg gtg tgg ctt cga gat gga cag atc cta gaa ctg gct gat      365
Pro Glu Val Val Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp         
    60                  65                  70                          

aac acc cag acc cag gtg cct ctg ggc gaa gac tgg caa gat gaa tgg      413
Asn Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp         
75                  80                  85                  90          

aaa gtt gtc agt cag ctc aga atc tca gcc ctg caa ctt tca gat gca      461
Lys Val Val Ser Gln Leu Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala         
                95                  100                 105             

ggg gag tac cag tgt atg gtg cat cta gaa gga cgg acc ttt gtg tct      509
Gly Glu Tyr Gln Cys Met Val His Leu Glu Gly Arg Thr Phe Val Ser         
            110                 115                 120                 

cag ccg ggc ttt gta ggg ctg gaa ggt ctc ccg tac ttc ctg gag gag      557
Gln Pro Gly Phe Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu         
        125                 130                 135                     

cct gag gac aaa gct gtg cct gcc aac acc cct ttc aac cta agc tgc      605
Pro Glu Asp Lys Ala Val Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys         
    140                 145                 150                         

cag gcc cag gga ccc ccg gaa ccc gtg acc cta ctc tgg ctt caa gat      653
Gln Ala Gln Gly Pro Pro Glu Pro Val Thr Leu Leu Trp Leu Gln Asp         
155                 160                 165                 170         

gct gtc ccc ctg gcc cca gtc aca gga cac agc tcc cag cac agt ctg      701
Ala Val Pro Leu Ala Pro Val Thr Gly His Ser Ser Gln His Ser Leu         
                175                 180                 185             

caa act cca ggc ctg aac aag aca tct tct ttc tca tgt gaa gcc cac      749
Gln Thr Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His         
            190                 195                 200                 

aat gcc aag gga gtc acc acc tcc cgc aca gcc acc atc aca gtg ctc      797
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu         
        205                 210                 215                     

ccc cag agg cct cac cat ctc cac gtg gtt tcc aga caa cct acg gag      845
Pro Gln Arg Pro His His Leu His Val Val Ser Arg Gln Pro Thr Glu         
    220                 225                 230                         

cta gag gta gct tgg acc cct ggc ctg agt ggc atc tac ccg ctc acc      893
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr         
235                 240                 245                 250         

cac tgc aac ctg cag gcc gtg ctg tca gac gat ggg gtg ggt atc tgg      941
His Cys Asn Leu Gln Ala Val Leu Ser Asp Asp Gly Val Gly Ile Trp         
                255                 260                 265             

ctg gga aag tca gat cct cct gaa gac ccc ctc acc ttg caa gta tca      989
Leu Gly Lys Ser Asp Pro Pro Glu Asp Pro Leu Thr Leu Gln Val Ser         
            270                 275                 280                 

gtg ccc ccc cac cag ctt cgg ctg gaa aag ctc ctt cct cac acc ccg     1037
Val Pro Pro His Gln Leu Arg Leu Glu Lys Leu Leu Pro His Thr Pro         
        285                 290                 295                     

tat cac atc cgg ata tcc tgc agc agc agc cag ggc ccc tca cct tgg     1085
Tyr His Ile Arg Ile Ser Cys Ser Ser Ser Gln Gly Pro Ser Pro Trp         
    300                 305                 310                         

acc cac tgg ctt cct gtg gag acc aca gag gga gtg ccc ttg ggt ccc     1133
Thr His Trp Leu Pro Val Glu Thr Thr Glu Gly Val Pro Leu Gly Pro         
315                 320                 325                 330         

cct gag aac gtt agc gcc atg cgg aat ggg agc cag gtc ctc gtg cgt     1181
Pro Glu Asn Val Ser Ala Met Arg Asn Gly Ser Gln Val Leu Val Arg         
                335                 340                 345             

tgg cag gag cca agg gtg ccc ctg caa ggc acc ctg tta ggg tac cgg     1229
Trp Gln Glu Pro Arg Val Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg         
            350                 355                 360                 

ctg gca tat cga ggc cag gac acc ccc gag gta ctt atg gat ata ggg     1277
Leu Ala Tyr Arg Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly         
        365                 370                 375                     

cta act cga gag gtg acc ttg gaa ctg cgg ggg gac agg cct gtg gct     1325
Leu Thr Arg Glu Val Thr Leu Glu Leu Arg Gly Asp Arg Pro Val Ala         
    380                 385                 390                         

aac ctg act gtg tct gtg aca gcc tat acc tcg gct ggg gat ggg ccc     1373
Asn Leu Thr Val Ser Val Thr Ala Tyr Thr Ser Ala Gly Asp Gly Pro         
395                 400                 405                 410         

tgg agc ctt cct gtg ccc cta gag ccc tgg cgc cca gtg agt gaa ccc     1421
Trp Ser Leu Pro Val Pro Leu Glu Pro Trp Arg Pro Val Ser Glu Pro         
                415                 420                 425             

cca cct cgc gcc ttc tcg tgg cct tgg tgg tat gta ctg ctg gga gca     1469
Pro Pro Arg Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala         
            430                 435                 440                 

ctt gtg gct gcc gcc tgc gtc ctc atc ttg gcc ctg ttc ctt gtc cat     1517
Leu Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His         
        445                 450                 455                     

cgg agg aag aag gag act cga tat ggg gag gtg ttt gag cca acc gtg     1565
Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val         
    460                 465                 470                         

gaa aga ggt gaa ctg gta gtc agg tac cgt gtc cga aag tcc tac agc     1613
Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser         
475                 480                 485                 490         

cgg cgg acc act gaa gcc acc ttg aac agt ctg ggc atc agt gaa gag     1661
Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu         
                495                 500                 505             

ctg aag gag aaa cta cga gac gtc atg gta gat cgg cat aag gtg gcc     1709
Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala         
            510                 515                 520                 

ttg ggg aag acc ctg gga gaa gga gaa ttt ggc gct gtg atg gaa ggt     1757
Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly         
        525                 530                 535                     

cag ctc aat cag gat gac tcc atc ctc aag gtc gct gtg aag acc atg     1805
Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met         
    540                 545                 550                         

aaa att gcc atc tgc aca aga tca gag ctg gag gat ttc ctg agt gaa     1853
Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu         
555                 560                 565                 570         

gct gtc tgc atg aag gaa ttt gac cac ccc aac gtc atg agg ctc att     1901
Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile         
                575                 580                 585             

ggc gtc tgt ttt cag ggc tct gac aga gag ggt ttc cca gaa cct gtg     1949
Gly Val Cys Phe Gln Gly Ser Asp Arg Glu Gly Phe Pro Glu Pro Val         
            590                 595                 600                 

gtc atc ttg cct ttc atg aaa cac gga gac cta cac agt ttc ctc ctg     1997
Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu         
        605                 610                 615                     

tac tcc cgg ctc ggg gac cag cca gtg ttc ctg ccc act cag atg cta     2045
Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe Leu Pro Thr Gln Met Leu         
    620                 625                 630                         

gtg aag ttc atg gcc gac att gcc agt ggt atg gag tac ctg agt acc     2093
Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr         
635                 640                 645                 650         

aag aga ttc ata cat cgg gac ctg gct gcc agg aac tgc atg ctg aat     2141
Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn         
                655                 660                 665             

gag aac atg tcc gtg tgt gtg gca gac ttc ggg ctc tcc aag aag atc     2189
Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile         
            670                 675                 680                 

tac aac ggg gat tac tac cgc caa ggg cgc att gcc aag atg cca gtc     2237
Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val         
        685                 690                 695                     

aag tgg att gct att gag agt ctg gca gat cgg gtc tac acc agc aag     2285
Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys         
    700                 705                 710                         

agc gat gtg tgg tcc ttc ggt gtg aca atg tgg gag atc gcc acc cga     2333
Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg         
715                 720                 725                 730         

ggc caa act ccc tat cca ggg gtg gag aac agt gag att tac gac tac     2381
Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr         
                735                 740                 745             

ctg cgt caa gga aat cgg ctg aaa cag cct gtg gac tgt ctg gac ggc     2429
Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Val Asp Cys Leu Asp Gly         
            750                 755                 760                 

ctg tat gcc ctg atg tct cgg tgc tgg gaa ctg aac cct cga gac cgg     2477
Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Arg Asp Arg         
        765                 770                 775                     

cca agt ttt gcg gag ctc cgg gaa gac ttg gag aac aca ctg aag gct     2525
Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala         
    780                 785                 790                         

ctg ccc cct gct cag gag cca gat gaa atc ctc tat gtc aac atg gat     2573
Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp         
795                 800                 805                 810         

gag ggc gga agc cac ctt gaa ccc cgt ggg gct gct gga gga gct gac     2621
Glu Gly Gly Ser His Leu Glu Pro Arg Gly Ala Ala Gly Gly Ala Asp         
                815                 820                 825             

ccc cca acc caa cct gat cct aag gat tcc tgt agc tgt ctc act gca     2669
Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala         
            830                 835                 840                 

gct gac gtc cac tca gct gga cgc tat gtc ctt tgt cct tct aca gcc     2717
Ala Asp Val His Ser Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Ala         
        845                 850                 855                     

cca gga ccc act ctg tct gct gac aga ggc tgc cca gca cct cca ggg     2765
Pro Gly Pro Thr Leu Ser Ala Asp Arg Gly Cys Pro Ala Pro Pro Gly         
    860                 865                 870                         

cag gag gac gga gcc tga gacaatcttc cacctgggac atcctctcag            2813
Gln Glu Asp Gly Ala                                                     
875                                                                     

gacccaagct aggcactgcc actgggggaa agctcacccc cccactccgt cactccaggc   2873

cttctcccca gatgcagaat ggccttccct cccttctcag atgcagtcca tgccttatgc   2933

accctatcca taacagtttc aagggatcgt ctcacatctt ccatcccagc gttctagatt   2993

ttaaggtttg agtttagagt tcaaagttct caaagatgat gagtctttgg accgagatgc   3053

ttgtttctag gtctgcagcg ctgttgctat agacaggccc actgctcgaa ggctctgaga   3113

ttctatggct ctagattttt ctggctctat aattcgtggc aatgctccca tggttttagg   3173

ttgcacgact ctgagattcc aggacctaag gcttctagac tttatttttc tggagccagg   3233

ggtcctgtca gtggaagatt gtagattttt aaattctaaa gattctaggc atgaaggttc   3293

taaggcatac tgcttctcca gtttaacagt ttagggctca tgttggaata ctccagatca   3353

taatgtttca aacttttatt ttttttaatt tctaagaccc cagtgatggt caactacaga   3413

ttctgaagcc ttatgaccat agattctttt atataaaaat cctgtatctc aaggaaatat   3473

gattctagac tctgaaattc caaagcttta agagtctcca gatggagttt ctaagctatg   3533

atgtggtgat aatctaaagt ttagtccaag gttctagatt cctaagcttc cacgtcatct   3593

gctcccagga ttccagatta ttaaactcta aaactctaat gttggcctga tcttcgtctc   3653

aggccctgta ggatgctgtg ggtcctcagc atctaagtca caagaggctc cagttaacga   3713

ggactaatga gacaccaaag ttctaaccac ttctaatgct ggacacctct aggttctatg   3773

ctgctttttg cctttctagc acataattaa atgcccaaga atacatatgt ctaaagatct   3833

taaatctcta agcactatgg agccaatgtt ttgagtgtct gagattctaa aggtccacag   3893

tctagagtat taggtacgac tccaagggtg ggcgcttgta gccatcctaa gtcctttccc   3953

tccttaagca cctatgctcc tcctctcctt gtgtggggta caccccacct taagcctgtg   4013

cgatgcactg ggaatgcctg ctttcctcca agggatgggt catctcccct catttggggc   4073

catgttgccc cttgagccag tcccctatgc ctgttctgaa gtgtggactc tggtgcctcc   4133

agagaggctc agatcacata aaacttttgt cagtcactaa aaaaaaaaaa aaaaaaaaaa   4193

aaaaaaa                                                             4200


<210>  6
<211>  879
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Arg Val Pro Leu Ala Trp Trp Leu Ala Leu Cys Cys Trp Gly 
1               5                   10                  15      


Cys Ala Ala His Lys Asp Thr Gln Thr Glu Ala Gly Ser Pro Phe Val 
            20                  25                  30          


Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu 
        35                  40                  45              


Arg Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Val Trp Leu 
    50                  55                  60                  


Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Asn Thr Gln Thr Gln Val 
65                  70                  75                  80  


Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp Lys Val Val Ser Gln Leu 
                85                  90                  95      


Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala Gly Glu Tyr Gln Cys Met 
            100                 105                 110         


Val His Leu Glu Gly Arg Thr Phe Val Ser Gln Pro Gly Phe Val Gly 
        115                 120                 125             


Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Lys Ala Val 
    130                 135                 140                 


Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro 
145                 150                 155                 160 


Glu Pro Val Thr Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Pro 
                165                 170                 175     


Val Thr Gly His Ser Ser Gln His Ser Leu Gln Thr Pro Gly Leu Asn 
            180                 185                 190         


Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr 
        195                 200                 205             


Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro His His 
    210                 215                 220                 


Leu His Val Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr 
225                 230                 235                 240 


Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Asn Leu Gln Ala 
                245                 250                 255     


Val Leu Ser Asp Asp Gly Val Gly Ile Trp Leu Gly Lys Ser Asp Pro 
            260                 265                 270         


Pro Glu Asp Pro Leu Thr Leu Gln Val Ser Val Pro Pro His Gln Leu 
        275                 280                 285             


Arg Leu Glu Lys Leu Leu Pro His Thr Pro Tyr His Ile Arg Ile Ser 
    290                 295                 300                 


Cys Ser Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val 
305                 310                 315                 320 


Glu Thr Thr Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala 
                325                 330                 335     


Met Arg Asn Gly Ser Gln Val Leu Val Arg Trp Gln Glu Pro Arg Val 
            340                 345                 350         


Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln 
        355                 360                 365             


Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Thr Arg Glu Val Thr 
    370                 375                 380                 


Leu Glu Leu Arg Gly Asp Arg Pro Val Ala Asn Leu Thr Val Ser Val 
385                 390                 395                 400 


Thr Ala Tyr Thr Ser Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro 
                405                 410                 415     


Leu Glu Pro Trp Arg Pro Val Ser Glu Pro Pro Pro Arg Ala Phe Ser 
            420                 425                 430         


Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala Leu Val Ala Ala Ala Cys 
        435                 440                 445             


Val Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr 
    450                 455                 460                 


Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val 
465                 470                 475                 480 


Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala 
                485                 490                 495     


Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg 
            500                 505                 510         


Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly 
        515                 520                 525             


Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp 
    530                 535                 540                 


Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr 
545                 550                 555                 560 


Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu 
                565                 570                 575     


Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly 
            580                 585                 590         


Ser Asp Arg Glu Gly Phe Pro Glu Pro Val Val Ile Leu Pro Phe Met 
        595                 600                 605             


Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp 
    610                 615                 620                 


Gln Pro Val Phe Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp 
625                 630                 635                 640 


Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg 
                645                 650                 655     


Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys 
            660                 665                 670         


Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr 
        675                 680                 685             


Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu 
    690                 695                 700                 


Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe 
705                 710                 715                 720 


Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro 
                725                 730                 735     


Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg 
            740                 745                 750         


Leu Lys Gln Pro Val Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser 
        755                 760                 765             


Arg Cys Trp Glu Leu Asn Pro Arg Asp Arg Pro Ser Phe Ala Glu Leu 
    770                 775                 780                 


Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu 
785                 790                 795                 800 


Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Ser His Leu 
                805                 810                 815     


Glu Pro Arg Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp 
            820                 825                 830         


Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Asp Val His Ser Ala 
        835                 840                 845             


Gly Arg Tyr Val Leu Cys Pro Ser Thr Ala Pro Gly Pro Thr Leu Ser 
    850                 855                 860                 


Ala Asp Arg Gly Cys Pro Ala Pro Pro Gly Gln Glu Asp Gly Ala 
865                 870                 875                 


<210>  7
<211>  2667
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(2667)

<400>  7
atg ggc agg gtc ccg ctg gcc tgg tgc gtg gcg ctg tgc tgc tgg ggg       48
Met Gly Arg Val Pro Leu Ala Trp Cys Val Ala Leu Cys Cys Trp Gly         
1               5                   10                  15              

tgt gca gcc cct aag gac aca cag acc gag gct gac agc cca ttc gtg       96
Cys Ala Ala Pro Lys Asp Thr Gln Thr Glu Ala Asp Ser Pro Phe Val         
            20                  25                  30                  

ggg aac cca ggg aat atc acg ggt gcc aga gga ctc acg ggg acc ctt      144
Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu         
        35                  40                  45                      

cgg tgt gag ctc cag gtt cag ggg gag ccc cct gag gtg atg tgg ctt      192
Arg Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Met Trp Leu         
    50                  55                  60                          

cga gat gga cag atc cta gaa ctg gct gat aac acc cag acc cag gtg      240
Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Asn Thr Gln Thr Gln Val         
65                  70                  75                  80          

cct ctg ggc gaa gac tgg caa gat gaa tgg aaa gtc gtc agt cag ctc      288
Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp Lys Val Val Ser Gln Leu         
                85                  90                  95              

aga atc tca gcc ctg caa ctt tca gat gca gga gag tac cag tgt atg      336
Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala Gly Glu Tyr Gln Cys Met         
            100                 105                 110                 

gtg cac ctg gaa gga cgg acc ttt gtg tct cag ccg ggc ttt gta gga      384
Val His Leu Glu Gly Arg Thr Phe Val Ser Gln Pro Gly Phe Val Gly         
        115                 120                 125                     

ctg gaa ggt ctc ccg tac ttc ctg gag gaa cct gaa gac aaa gct gtg      432
Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Lys Ala Val         
    130                 135                 140                         

cct gcc aac acc ccc ttc aac cta agc tgc cag gcc cag gga ccc ccg      480
Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro         
145                 150                 155                 160         

gaa ccc gtg acc ctg ctc tgg ctt caa gat gct gtc cct ctg gcc cca      528
Glu Pro Val Thr Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Pro         
                165                 170                 175             

gtc gca gga tac agc ttt cag cac agt ttg caa gct cca ggc ctg aac      576
Val Ala Gly Tyr Ser Phe Gln His Ser Leu Gln Ala Pro Gly Leu Asn         
            180                 185                 190                 

aag aca tct tct ttc tca tgt gaa gcc cac aat gcc aag gga gtc acc      624
Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr         
        195                 200                 205                     

acc tcc cgc aca gct acc atc aca gtg ctc cca cag aga cct cac aat      672
Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro His Asn         
    210                 215                 220                         

ctc cac gtg gtt tcc aga cat ccc acg gag cta gag gta gct tgg atc      720
Leu His Val Val Ser Arg His Pro Thr Glu Leu Glu Val Ala Trp Ile         
225                 230                 235                 240         

cct acc ctg agt ggc atc tac ccg ctc acc cac tgc acc ctg cag gct      768
Pro Thr Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala         
                245                 250                 255             

gtg ctg tca aac gat ggg gtg ggc gtc tgg ctg gga aag tca gat cct      816
Val Leu Ser Asn Asp Gly Val Gly Val Trp Leu Gly Lys Ser Asp Pro         
            260                 265                 270                 

cct gaa gaa ccc ctc acc gtg caa gta tca gtg ccc ccc cac cag ctt      864
Pro Glu Glu Pro Leu Thr Val Gln Val Ser Val Pro Pro His Gln Leu         
        275                 280                 285                     

cgg ctg gaa aag ctc ctt cct cac acc cca tat cac atc cgg gta tcc      912
Arg Leu Glu Lys Leu Leu Pro His Thr Pro Tyr His Ile Arg Val Ser         
    290                 295                 300                         

tgc act agc agc cag ggc ccc tca cct tgg acc cac tgg ctt cct gtg      960
Cys Thr Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val         
305                 310                 315                 320         

gag acc acg gag gga gtg ccc ttg ggt ccc cct gag aac gtt agc gcc     1008
Glu Thr Thr Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala         
                325                 330                 335             

atg cgg aat ggg agc cag gcc ctc gtg cgt tgg cag gag cca agg gag     1056
Met Arg Asn Gly Ser Gln Ala Leu Val Arg Trp Gln Glu Pro Arg Glu         
            340                 345                 350                 

ccc ttg cag ggc acc ctg tta ggg tac cgg ctg gca tat cga ggc cag     1104
Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln         
        355                 360                 365                     

gac acc ccc gag gta ctt atg gat ata ggg cta act cga gag gtg acc     1152
Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Thr Arg Glu Val Thr         
    370                 375                 380                         

ttg gaa ctt cgg ggg gac agg cct gtg gct aac ctg act gtg tct gtg     1200
Leu Glu Leu Arg Gly Asp Arg Pro Val Ala Asn Leu Thr Val Ser Val         
385                 390                 395                 400         

gca gcc tat acc tca gct ggg gat ggg ccc tgg agc ctt cct gtg ccc     1248
Ala Ala Tyr Thr Ser Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro         
                405                 410                 415             

cta gag ccc tgg cgc cca ggg caa gga cag cca ctc cac cat ctg gtg     1296
Leu Glu Pro Trp Arg Pro Gly Gln Gly Gln Pro Leu His His Leu Val         
            420                 425                 430                 

agt gaa ccc cca cct ccc gcc ttc tcg tgg cct tgg tgg tat gta ctg     1344
Ser Glu Pro Pro Pro Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu         
        435                 440                 445                     

ctg gga gca ctt gtg gcc gcc gcc tgt gtc ctt atc ttg acc ctg ttc     1392
Leu Gly Ala Leu Val Ala Ala Ala Cys Val Leu Ile Leu Thr Leu Phe         
    450                 455                 460                         

ctt gtc cat cgg agg aag aag gag acg aga tat ggg gag gtg ttc gag     1440
Leu Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu         
465                 470                 475                 480         

cca act gtg gaa agg ggt gaa ctg gta gtc agg tac cgt gcc cga aag     1488
Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Ala Arg Lys         
                485                 490                 495             

tcc tac agt cgc cgg acc acg gaa gcc acc ttg aac agt ctg ggc atc     1536
Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile         
            500                 505                 510                 

agc gaa gag ctg aag gag aaa cta cga gac gtc atg gta gat cgg cat     1584
Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His         
        515                 520                 525                     

aag gtg gcc ttg ggg aag acc ctg gga gag gga gaa ttt ggt gct gtg     1632
Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val         
    530                 535                 540                         

atg gag ggc cag ctc aac cag gat gac tcc atc ctc aag gtc gct gtg     1680
Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val         
545                 550                 555                 560         

aag acc atg aaa att gcc atc tgc aca aga tca gag ctg gag gat ttc     1728
Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe         
                565                 570                 575             

ctg agt gaa gct gtc tgc atg aag gaa ttt gac cac ccc aac gtc atg     1776
Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met         
            580                 585                 590                 

agg ctc att ggc gtc tgt ttc cag ggt tct gac cga gag ggt ttc cca     1824
Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Asp Arg Glu Gly Phe Pro         
        595                 600                 605                     

gaa ccg gtg gtc atc ttg cct ttc atg aaa cat gga gac ctc cac agt     1872
Glu Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser         
    610                 615                 620                         

ttc ctc ctg tac tcg cgg ctc ggg gac cag cca gtg ttc ctg ccc act     1920
Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe Leu Pro Thr         
625                 630                 635                 640         

cag atg cta gtg aag ttt atg gcc gac att gcc agt ggc atg gag tac     1968
Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr         
                645                 650                 655             

ctc agt acc aag aga ttc ata cac cgg gac cta gct gcc agg aac tgc     2016
Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys         
            660                 665                 670                 

atg ctg aat gag aac atg tcc gtg tgc gtg gca gac ttc ggg ctc tcc     2064
Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser         
        675                 680                 685                     

aag aag atc tac aat ggg gat tac tac cgc caa ggg cgc att gcc aag     2112
Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys         
    690                 695                 700                         

atg cca gtc aag tgg att gct atc gag agt ctg gca gat cga gtc tac     2160
Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr         
705                 710                 715                 720         

acc agc aag agt gac gtg tgg tcc ttc ggt gtg aca atg tgg gag atc     2208
Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile         
                725                 730                 735             

gcc acc cga ggc caa act ccc tat cca ggg gtg gag aac agt gag att     2256
Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile         
            740                 745                 750                 

tac gac tac cta cgt caa gga aat cgc ctg aaa cag cct ctg gac tgt     2304
Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Leu Asp Cys         
        755                 760                 765                     

ctg gat ggc ctc tat gcc ctg atg tcc cgg tgc tgg gag ctg aac cct     2352
Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro         
    770                 775                 780                         

cga gac cgg cca agt ttt gca gag ctc cgg gaa gac ttg gag aac aca     2400
Arg Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr         
785                 790                 795                 800         

ttg aag gct cta ccc cct gct cag gag cct gat gaa atc ctc tat gtc     2448
Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val         
                805                 810                 815             

aac atg gat gag ggc gga agt cac ctt gaa ccc cgt ggg gct gct gga     2496
Asn Met Asp Glu Gly Gly Ser His Leu Glu Pro Arg Gly Ala Ala Gly         
            820                 825                 830                 

gga gct gac ccc cca acc caa cct gat cct aag gat tac tgt agc tgt     2544
Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Tyr Cys Ser Cys         
        835                 840                 845                     

ctc act gca gct gac gtc cac tca gct gga cgc tat gtc ctt tgt cct     2592
Leu Thr Ala Ala Asp Val His Ser Ala Gly Arg Tyr Val Leu Cys Pro         
    850                 855                 860                         

tct aca gcc cca gga ccc act ctg tct gct gac aga ggc tgc cca gca     2640
Ser Thr Ala Pro Gly Pro Thr Leu Ser Ala Asp Arg Gly Cys Pro Ala         
865                 870                 875                 880         

cct cca ggg cag gag gac gga gcc tga                                 2667
Pro Pro Gly Gln Glu Asp Gly Ala                                         
                885                                                     


<210>  8
<211>  888
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Gly Arg Val Pro Leu Ala Trp Cys Val Ala Leu Cys Cys Trp Gly 
1               5                   10                  15      


Cys Ala Ala Pro Lys Asp Thr Gln Thr Glu Ala Asp Ser Pro Phe Val 
            20                  25                  30          


Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu 
        35                  40                  45              


Arg Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Met Trp Leu 
    50                  55                  60                  


Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Asn Thr Gln Thr Gln Val 
65                  70                  75                  80  


Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp Lys Val Val Ser Gln Leu 
                85                  90                  95      


Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala Gly Glu Tyr Gln Cys Met 
            100                 105                 110         


Val His Leu Glu Gly Arg Thr Phe Val Ser Gln Pro Gly Phe Val Gly 
        115                 120                 125             


Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Lys Ala Val 
    130                 135                 140                 


Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro 
145                 150                 155                 160 


Glu Pro Val Thr Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Pro 
                165                 170                 175     


Val Ala Gly Tyr Ser Phe Gln His Ser Leu Gln Ala Pro Gly Leu Asn 
            180                 185                 190         


Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr 
        195                 200                 205             


Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro His Asn 
    210                 215                 220                 


Leu His Val Val Ser Arg His Pro Thr Glu Leu Glu Val Ala Trp Ile 
225                 230                 235                 240 


Pro Thr Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala 
                245                 250                 255     


Val Leu Ser Asn Asp Gly Val Gly Val Trp Leu Gly Lys Ser Asp Pro 
            260                 265                 270         


Pro Glu Glu Pro Leu Thr Val Gln Val Ser Val Pro Pro His Gln Leu 
        275                 280                 285             


Arg Leu Glu Lys Leu Leu Pro His Thr Pro Tyr His Ile Arg Val Ser 
    290                 295                 300                 


Cys Thr Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val 
305                 310                 315                 320 


Glu Thr Thr Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala 
                325                 330                 335     


Met Arg Asn Gly Ser Gln Ala Leu Val Arg Trp Gln Glu Pro Arg Glu 
            340                 345                 350         


Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln 
        355                 360                 365             


Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Thr Arg Glu Val Thr 
    370                 375                 380                 


Leu Glu Leu Arg Gly Asp Arg Pro Val Ala Asn Leu Thr Val Ser Val 
385                 390                 395                 400 


Ala Ala Tyr Thr Ser Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro 
                405                 410                 415     


Leu Glu Pro Trp Arg Pro Gly Gln Gly Gln Pro Leu His His Leu Val 
            420                 425                 430         


Ser Glu Pro Pro Pro Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu 
        435                 440                 445             


Leu Gly Ala Leu Val Ala Ala Ala Cys Val Leu Ile Leu Thr Leu Phe 
    450                 455                 460                 


Leu Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu 
465                 470                 475                 480 


Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Ala Arg Lys 
                485                 490                 495     


Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile 
            500                 505                 510         


Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His 
        515                 520                 525             


Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val 
    530                 535                 540                 


Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val 
545                 550                 555                 560 


Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe 
                565                 570                 575     


Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met 
            580                 585                 590         


Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Asp Arg Glu Gly Phe Pro 
        595                 600                 605             


Glu Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser 
    610                 615                 620                 


Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe Leu Pro Thr 
625                 630                 635                 640 


Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr 
                645                 650                 655     


Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
            660                 665                 670         


Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser 
        675                 680                 685             


Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys 
    690                 695                 700                 


Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr 
705                 710                 715                 720 


Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile 
                725                 730                 735     


Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile 
            740                 745                 750         


Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Leu Asp Cys 
        755                 760                 765             


Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro 
    770                 775                 780                 


Arg Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr 
785                 790                 795                 800 


Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val 
                805                 810                 815     


Asn Met Asp Glu Gly Gly Ser His Leu Glu Pro Arg Gly Ala Ala Gly 
            820                 825                 830         


Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Tyr Cys Ser Cys 
        835                 840                 845             


Leu Thr Ala Ala Asp Val His Ser Ala Gly Arg Tyr Val Leu Cys Pro 
    850                 855                 860                 


Ser Thr Ala Pro Gly Pro Thr Leu Ser Ala Asp Arg Gly Cys Pro Ala 
865                 870                 875                 880 


Pro Pro Gly Gln Glu Asp Gly Ala 
                885             


<210>  9
<211>  4961
<212>  DNA
<213>  Gallus gallus


<220>
<221>  CDS
<222>  (229)..(2850)

<400>  9
agcgcggtgg cggagggccg ggcccggccc cggaggaggc gccgcgcggc cgcgcgccga     60

tagggggaga gcgcccggca ctcagcgccc ggcggcggca ccgcaccgca ccgcgttcgg    120

agcgccgctg cccggccgga gccgccgcgg aacttggagc gttcccacag cgtcccagcg    180

cggcccggcg gagccgagga gccgggggag gatggtggtg cgggagag atg gag ctg     237
                                                     Met Glu Leu        
                                                     1                  

agg cgg agc atg gcg ctg ccg cgg ctc ctc ttg ctg gga ctg tgg gct      285
Arg Arg Ser Met Ala Leu Pro Arg Leu Leu Leu Leu Gly Leu Trp Ala         
    5                   10                  15                          

gcg gcg ctt cgg gac ggc gcc gtg gcg gca ggt atg aag ttt aca gga      333
Ala Ala Leu Arg Asp Gly Ala Val Ala Ala Gly Met Lys Phe Thr Gly         
20                  25                  30                  35          

tct cca atc aaa tta aag gtg tcc cag ggt caa ccc gtc aaa cta aat      381
Ser Pro Ile Lys Leu Lys Val Ser Gln Gly Gln Pro Val Lys Leu Asn         
                40                  45                  50              

tgc agc ctg gag gga atg gaa gat ccc gag atg ttg tgg atc aag gac      429
Cys Ser Leu Glu Gly Met Glu Asp Pro Glu Met Leu Trp Ile Lys Asp         
            55                  60                  65                  

gga gca gtg gtg caa agc gta gac cag gtg tac att cca gta gat gaa      477
Gly Ala Val Val Gln Ser Val Asp Gln Val Tyr Ile Pro Val Asp Glu         
        70                  75                  80                      

gat cac tgg atc ggc ttc ctc agc ctg aaa tcc gtc gag agg aca gat      525
Asp His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Thr Asp         
    85                  90                  95                          

tct ggg aag tac tgg tgc cag gtt gag aac ggg ggg aag aag gaa gaa      573
Ser Gly Lys Tyr Trp Cys Gln Val Glu Asn Gly Gly Lys Lys Glu Glu         
100                 105                 110                 115         

tca cag caa gtg tgg ctc ata gtg gaa ggt gtg ccc tac ttt act gtg      621
Ser Gln Gln Val Trp Leu Ile Val Glu Gly Val Pro Tyr Phe Thr Val         
                120                 125                 130             

gaa cct gag gat gtg tcc gtg tcc cct aat gcc cca ttt cat atg gcc      669
Glu Pro Glu Asp Val Ser Val Ser Pro Asn Ala Pro Phe His Met Ala         
            135                 140                 145                 

tgt gct gct gtt ggt ccc cct gaa cca gtg aca att gtc tgg tgg atg      717
Cys Ala Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Met         
        150                 155                 160                     

gga gac tct aga gtg ggg ctt cca gac atc tcc ccc tcc atc cta aac      765
Gly Asp Ser Arg Val Gly Leu Pro Asp Ile Ser Pro Ser Ile Leu Asn         
    165                 170                 175                         

gtg tca ggt att aat caa agc aca atg ttc tcc tgc gaa gct cac aac      813
Val Ser Gly Ile Asn Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn         
180                 185                 190                 195         

gta aag gga ttg tct tca tct cgg aca gcc act gtt cag att aaa gcc      861
Val Lys Gly Leu Ser Ser Ser Arg Thr Ala Thr Val Gln Ile Lys Ala         
                200                 205                 210             

atg cct ctg cca ccc ctc aac gtg acg gtg agc cag gtc acc agc agc      909
Met Pro Leu Pro Pro Leu Asn Val Thr Val Ser Gln Val Thr Ser Ser         
            215                 220                 225                 

aat gcc agt gtg gtc tgg gtg ccg ggg ttt gat ggc cgt gct ccc ctc      957
Asn Ala Ser Val Val Trp Val Pro Gly Phe Asp Gly Arg Ala Pro Leu         
        230                 235                 240                     

cat tct tgc act ctt cag gtt gct gag tcc cca gat ggc cag gag gtc     1005
His Ser Cys Thr Leu Gln Val Ala Glu Ser Pro Asp Gly Gln Glu Val         
    245                 250                 255                         

tcc acc gaa gtc gcc cca gtg cct ccc ttt gcc tat ggc gtg cag ggc     1053
Ser Thr Glu Val Ala Pro Val Pro Pro Phe Ala Tyr Gly Val Gln Gly         
260                 265                 270                 275         

ctg aag cac tcc acc aac tac agt gtt cgt gtg cag tgc agc aat gag     1101
Leu Lys His Ser Thr Asn Tyr Ser Val Arg Val Gln Cys Ser Asn Glu         
                280                 285                 290             

atg ggc agc tcc cct ttc aca gag aga gtt tac ttc cag aca ctg gag     1149
Met Gly Ser Ser Pro Phe Thr Glu Arg Val Tyr Phe Gln Thr Leu Glu         
            295                 300                 305                 

ctt gct cca agc agc acc cca caa aat atc cat gtg atc caa agg gat     1197
Leu Ala Pro Ser Ser Thr Pro Gln Asn Ile His Val Ile Gln Arg Asp         
        310                 315                 320                     

cct ggt ttg gtt ttg gag tgg gaa ggc gtg gct cca gac gtg ctg aaa     1245
Pro Gly Leu Val Leu Glu Trp Glu Gly Val Ala Pro Asp Val Leu Lys         
    325                 330                 335                         

gaa aat gtc ctg gga tac agg ctg gag tgg att cag gat aat gtg act     1293
Glu Asn Val Leu Gly Tyr Arg Leu Glu Trp Ile Gln Asp Asn Val Thr         
340                 345                 350                 355         

cag ggg gag atg atc gtg cag gat aca aaa gca aat ctc aca acg tgg     1341
Gln Gly Glu Met Ile Val Gln Asp Thr Lys Ala Asn Leu Thr Thr Trp         
                360                 365                 370             

aac cct ctc aaa gac cta atc atc agg gtg tgt gtg ctg aac tcg gct     1389
Asn Pro Leu Lys Asp Leu Ile Ile Arg Val Cys Val Leu Asn Ser Ala         
            375                 380                 385                 

ggg tgc gga cca tgg agt gac ctc ttc ctg ctg gaa gcc cag gag gtc     1437
Gly Cys Gly Pro Trp Ser Asp Leu Phe Leu Leu Glu Ala Gln Glu Val         
        390                 395                 400                     

atg ggt ggt cag aga cag cct cct tat ggg aca tcc tgg gtt cct gtg     1485
Met Gly Gly Gln Arg Gln Pro Pro Tyr Gly Thr Ser Trp Val Pro Val         
    405                 410                 415                         

gca ttg ggc att ctc aca gct ctg gtc aca gct gtt gcc ttg gct ctt     1533
Ala Leu Gly Ile Leu Thr Ala Leu Val Thr Ala Val Ala Leu Ala Leu         
420                 425                 430                 435         

att ctc ctt cga aaa aga aga aag gaa act cga ttt ggc cat gcc ttt     1581
Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly His Ala Phe         
                440                 445                 450             

ggt agt gtg gtt ggc aga ggg gat cca gct gtc cat ttc aga gct gcc     1629
Gly Ser Val Val Gly Arg Gly Asp Pro Ala Val His Phe Arg Ala Ala         
            455                 460                 465                 

agg tct ttc aac agg gag ggc cca gag ctc att gaa gca aca ttg gag     1677
Arg Ser Phe Asn Arg Glu Gly Pro Glu Leu Ile Glu Ala Thr Leu Glu         
        470                 475                 480                     

agt gta ggg atc agt gat gag ctg aag aca aaa ctg aaa gat gtc ctt     1725
Ser Val Gly Ile Ser Asp Glu Leu Lys Thr Lys Leu Lys Asp Val Leu         
    485                 490                 495                         

atc cag gag cag cag ttc acc ttg gga cga atg tta ggc aaa gga gag     1773
Ile Gln Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu         
500                 505                 510                 515         

ttt ggg tca gtt cga gag gca cta ctg aag cta gat gat ggc tct ttc     1821
Phe Gly Ser Val Arg Glu Ala Leu Leu Lys Leu Asp Asp Gly Ser Phe         
                520                 525                 530             

cag aaa gtg gca gtt aag atg ctg aaa gcg gac atc ttc acc tcc act     1869
Gln Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Phe Thr Ser Thr         
            535                 540                 545                 

gac atc gag gag ttc ctg cgg gag gct gcg tgt atg aag gag ttt gac     1917
Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp         
        550                 555                 560                     

cac cca cat gtc act aag ctg att gga gtc agt cta cgg agc cgt ccc     1965
His Pro His Val Thr Lys Leu Ile Gly Val Ser Leu Arg Ser Arg Pro         
    565                 570                 575                         

aag ggc cgt ctc cca att ccc atg gtg atc ctg ccc ttc atg aag cat     2013
Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His         
580                 585                 590                 595         

gga gac ctt cat gct ttt ctg ctg atg tca agg atc ggg gaa aac cct     2061
Gly Asp Leu His Ala Phe Leu Leu Met Ser Arg Ile Gly Glu Asn Pro         
                600                 605                 610             

ttt aac ttg cct ctt cag aca ctc ctc aag ttc atg att gac att gcc     2109
Phe Asn Leu Pro Leu Gln Thr Leu Leu Lys Phe Met Ile Asp Ile Ala         
            615                 620                 625                 

agt ggg atg gag tac ttg agc tca aaa aat ttc ata cac aga gac ctt     2157
Ser Gly Met Glu Tyr Leu Ser Ser Lys Asn Phe Ile His Arg Asp Leu         
        630                 635                 640                     

gca gct cgg aac tgc atg ctg gat gag aac atg aat gtg agt gtt gca     2205
Ala Ala Arg Asn Cys Met Leu Asp Glu Asn Met Asn Val Ser Val Ala         
    645                 650                 655                         

gac ttc ggc ctt tct aag aaa atc tac agt gga gac tac tac cgt cag     2253
Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln         
660                 665                 670                 675         

ggc tgt gcc tcc aag ctg cca gtg aag tgg ctt gct ctg gaa agc ctg     2301
Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu         
                680                 685                 690             

gcg gat aat ctg tac aca aca cac agc gat gtg tgg gcg ttt ggg gtg     2349
Ala Asp Asn Leu Tyr Thr Thr His Ser Asp Val Trp Ala Phe Gly Val         
            695                 700                 705                 

acc atg tgg gag att gtg acc cga ggg caa acc cct tat gct ggc att     2397
Thr Met Trp Glu Ile Val Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile         
        710                 715                 720                     

gag aat gca gaa atc tac aac tac ctc atc agt ggg aac agg ctg aag     2445
Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Ser Gly Asn Arg Leu Lys         
    725                 730                 735                         

cag cca ccg gag tgc ctg gaa gat gtc tac gat ctc atg tgc aga tgt     2493
Gln Pro Pro Glu Cys Leu Glu Asp Val Tyr Asp Leu Met Cys Arg Cys         
740                 745                 750                 755         

tgg cat cct gag ccc aag cta cgc cca agc ttt gga gtg ctc cgg tcc     2541
Trp His Pro Glu Pro Lys Leu Arg Pro Ser Phe Gly Val Leu Arg Ser         
                760                 765                 770             

cag ctg gaa atg att cgg ggg agg atg tcc aca ctc tcc tta agc caa     2589
Gln Leu Glu Met Ile Arg Gly Arg Met Ser Thr Leu Ser Leu Ser Gln         
            775                 780                 785                 

gac cct ctc tat gtc aac att ggg aag gac aaa gag tca tct gtc agt     2637
Asp Pro Leu Tyr Val Asn Ile Gly Lys Asp Lys Glu Ser Ser Val Ser         
        790                 795                 800                     

gac cct gcc gtg cac acc tct ttt gga aac acg gac ggt gat gag acc     2685
Asp Pro Ala Val His Thr Ser Phe Gly Asn Thr Asp Gly Asp Glu Thr         
    805                 810                 815                         

att gct ggg gca gca gct gct gcc atc acg agt gac tat cgc tac atc     2733
Ile Ala Gly Ala Ala Ala Ala Ala Ile Thr Ser Asp Tyr Arg Tyr Ile         
820                 825                 830                 835         

atg agc ccc ttg tgc ctt gga gat gat gtc gag ggt gaa agg cat cca     2781
Met Ser Pro Leu Cys Leu Gly Asp Asp Val Glu Gly Glu Arg His Pro         
                840                 845                 850             

gaa ggg cag gaa ggg gag aac aaa agc ctt ctg tat gag ctg gag aca     2829
Glu Gly Gln Glu Gly Glu Asn Lys Ser Leu Leu Tyr Glu Leu Glu Thr         
            855                 860                 865                 

gaa gga gag aaa agt tgt tag tctgtacata gcagtgacac tctgcttccc        2880
Glu Gly Glu Lys Ser Cys                                                 
        870                                                             

tgggacggga tgtgtgcagc cacagtgccg cgtcgcctga gtcttcgatg ccggatctgg   2940

agtggcttta aacagcacag gctggagctc ttgggcagct ttggcagctt tcatttctgt   3000

atgggctgca gttgcggaca gcttggatgg accgcagccc tgacatgccc ttggatttgg   3060

ggagggaggc ggtagggtgg caggctgttc acatcccgca gaaagaaggt caaagccaag   3120

gtgggcagtc agagcctctg ctctggtctt tctcactggc agctggagca gagctgaacg   3180

caccttctgt tcggtcagtg ctcgctctcg tgtagatgtt gtctttgatc ctggctgcgt   3240

gacttcggga ctggtacctc tgaaaacact agtgggtatt tacaccgtca tcaggacacc   3300

gggggaagtt cctcttgtgt tcactcagca gtgctgccta gacgtcttgc ctacctcagt   3360

ggttctcaaa ctacgatctg cagatctgca ttcacccgac attgaacatc tggcacattt   3420

catgcagtaa tgctcgctgc tccctctacc cagggctctt ttaaggtact cagacttgca   3480

gtgagcaatg aaattagaaa aaaaaaaaga aaatggagca tccctctctg ccccacatgc   3540

ctcttttatg tgtttttctt tctgtttggt gccggtttag gcctgaccaa ccttgcagtt   3600

ggccttcaaa tgggaaggga gggagagcag ctggcatggg tgagggcaga atctaacttc   3660

aaaggaattg agaggaaact gtgtagagag gacttgtcgg cagtgtgggg aagcagtgct   3720

aattaatgca aaatgctgcc ctccaggaga ggaaggagac tgcttagata gagaatggcg   3780

gacacgcatc actttcagca ggagcaggat tcagcatttg cttgaaagta ggattccttt   3840

aatctttctc tttttaacca tcctctgact ttttcaaaca atccagtgct gtagctgctg   3900

tggtgaaggt ctgaagtcag tttggggaag gtatgtgtga gatgggggga agggaccaac   3960

cgggaaatct ctttctaaag agagaatcct tatcacgaaa aagcttgaga accactggcc   4020

gtcttattta ggaggtcttc tggcacactg taaaagccac atcagatcat agacccgtat   4080

caccgcagcc ttccacgcag ggcaaaattg atggttttgc tctttgggtt ttgttttcca   4140

atcagcatgt ctgactcact gtaactgcaa gtgcttttgt ggtttttaat aatttaatat   4200

tttaatgtaa aatcagcatt tgttttgtgc agtgtttccc agcaaggaag tgcagctaca   4260

tcttactcta gttatcctaa atatttgcta gatcttcatt tgttttattt tcagcgtgct   4320

gaaaactcag cagtaccaca ggacttagga ttccacactg cttttcctca gacacaaata   4380

ccaccaacgt cgtcgcttgc caggttggcg aaggtggaac caatgagcca agttagactg   4440

caggctcagt atcaggacac cctaccattc gatgccccgt tcttggctgt tgccgggtga   4500

ggggctcact gcaaaatttg ggtccagttt catcccttgc tgagagcacc ttcctgcgga   4560

agggaaagtt cagcctgggg cttgggcatg ggtcctttct gtaagatttc ctactaccca   4620

acgctgccct acagctggaa gcccagtatg gtttcttggt cacaaactgc aaaacattac   4680

accccaggca gtacgggttt ttttccatca tttagctgga tcgctgtcaa tgcaggtgag   4740

aaaataacag ctaacgaagg ttagcagaaa cgtgtgcggt gcacacattg gcagtgaggg   4800

cagaaggctg tgctccctgt aactgcctgg gaagcgcaga tgtacataga gactctaact   4860

ttgggaagca tgtcatagtt tttatgcatt tttttaaata ataaaacatg tactgtgtct   4920

gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       4961


<210>  10
<211>  873
<212>  PRT
<213>  Gallus gallus

<400>  10

Met Glu Leu Arg Arg Ser Met Ala Leu Pro Arg Leu Leu Leu Leu Gly 
1               5                   10                  15      


Leu Trp Ala Ala Ala Leu Arg Asp Gly Ala Val Ala Ala Gly Met Lys 
            20                  25                  30          


Phe Thr Gly Ser Pro Ile Lys Leu Lys Val Ser Gln Gly Gln Pro Val 
        35                  40                  45              


Lys Leu Asn Cys Ser Leu Glu Gly Met Glu Asp Pro Glu Met Leu Trp 
    50                  55                  60                  


Ile Lys Asp Gly Ala Val Val Gln Ser Val Asp Gln Val Tyr Ile Pro 
65                  70                  75                  80  


Val Asp Glu Asp His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu 
                85                  90                  95      


Arg Thr Asp Ser Gly Lys Tyr Trp Cys Gln Val Glu Asn Gly Gly Lys 
            100                 105                 110         


Lys Glu Glu Ser Gln Gln Val Trp Leu Ile Val Glu Gly Val Pro Tyr 
        115                 120                 125             


Phe Thr Val Glu Pro Glu Asp Val Ser Val Ser Pro Asn Ala Pro Phe 
    130                 135                 140                 


His Met Ala Cys Ala Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val 
145                 150                 155                 160 


Trp Trp Met Gly Asp Ser Arg Val Gly Leu Pro Asp Ile Ser Pro Ser 
                165                 170                 175     


Ile Leu Asn Val Ser Gly Ile Asn Gln Ser Thr Met Phe Ser Cys Glu 
            180                 185                 190         


Ala His Asn Val Lys Gly Leu Ser Ser Ser Arg Thr Ala Thr Val Gln 
        195                 200                 205             


Ile Lys Ala Met Pro Leu Pro Pro Leu Asn Val Thr Val Ser Gln Val 
    210                 215                 220                 


Thr Ser Ser Asn Ala Ser Val Val Trp Val Pro Gly Phe Asp Gly Arg 
225                 230                 235                 240 


Ala Pro Leu His Ser Cys Thr Leu Gln Val Ala Glu Ser Pro Asp Gly 
                245                 250                 255     


Gln Glu Val Ser Thr Glu Val Ala Pro Val Pro Pro Phe Ala Tyr Gly 
            260                 265                 270         


Val Gln Gly Leu Lys His Ser Thr Asn Tyr Ser Val Arg Val Gln Cys 
        275                 280                 285             


Ser Asn Glu Met Gly Ser Ser Pro Phe Thr Glu Arg Val Tyr Phe Gln 
    290                 295                 300                 


Thr Leu Glu Leu Ala Pro Ser Ser Thr Pro Gln Asn Ile His Val Ile 
305                 310                 315                 320 


Gln Arg Asp Pro Gly Leu Val Leu Glu Trp Glu Gly Val Ala Pro Asp 
                325                 330                 335     


Val Leu Lys Glu Asn Val Leu Gly Tyr Arg Leu Glu Trp Ile Gln Asp 
            340                 345                 350         


Asn Val Thr Gln Gly Glu Met Ile Val Gln Asp Thr Lys Ala Asn Leu 
        355                 360                 365             


Thr Thr Trp Asn Pro Leu Lys Asp Leu Ile Ile Arg Val Cys Val Leu 
    370                 375                 380                 


Asn Ser Ala Gly Cys Gly Pro Trp Ser Asp Leu Phe Leu Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Val Met Gly Gly Gln Arg Gln Pro Pro Tyr Gly Thr Ser Trp 
                405                 410                 415     


Val Pro Val Ala Leu Gly Ile Leu Thr Ala Leu Val Thr Ala Val Ala 
            420                 425                 430         


Leu Ala Leu Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly 
        435                 440                 445             


His Ala Phe Gly Ser Val Val Gly Arg Gly Asp Pro Ala Val His Phe 
    450                 455                 460                 


Arg Ala Ala Arg Ser Phe Asn Arg Glu Gly Pro Glu Leu Ile Glu Ala 
465                 470                 475                 480 


Thr Leu Glu Ser Val Gly Ile Ser Asp Glu Leu Lys Thr Lys Leu Lys 
                485                 490                 495     


Asp Val Leu Ile Gln Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly 
            500                 505                 510         


Lys Gly Glu Phe Gly Ser Val Arg Glu Ala Leu Leu Lys Leu Asp Asp 
        515                 520                 525             


Gly Ser Phe Gln Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Phe 
    530                 535                 540                 


Thr Ser Thr Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys 
545                 550                 555                 560 


Glu Phe Asp His Pro His Val Thr Lys Leu Ile Gly Val Ser Leu Arg 
                565                 570                 575     


Ser Arg Pro Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe 
            580                 585                 590         


Met Lys His Gly Asp Leu His Ala Phe Leu Leu Met Ser Arg Ile Gly 
        595                 600                 605             


Glu Asn Pro Phe Asn Leu Pro Leu Gln Thr Leu Leu Lys Phe Met Ile 
    610                 615                 620                 


Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Ser Lys Asn Phe Ile His 
625                 630                 635                 640 


Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Asn Met Asn Val 
                645                 650                 655     


Ser Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp Tyr 
            660                 665                 670         


Tyr Arg Gln Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu 
        675                 680                 685             


Glu Ser Leu Ala Asp Asn Leu Tyr Thr Thr His Ser Asp Val Trp Ala 
    690                 695                 700                 


Phe Gly Val Thr Met Trp Glu Ile Val Thr Arg Gly Gln Thr Pro Tyr 
705                 710                 715                 720 


Ala Gly Ile Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Ser Gly Asn 
                725                 730                 735     


Arg Leu Lys Gln Pro Pro Glu Cys Leu Glu Asp Val Tyr Asp Leu Met 
            740                 745                 750         


Cys Arg Cys Trp His Pro Glu Pro Lys Leu Arg Pro Ser Phe Gly Val 
        755                 760                 765             


Leu Arg Ser Gln Leu Glu Met Ile Arg Gly Arg Met Ser Thr Leu Ser 
    770                 775                 780                 


Leu Ser Gln Asp Pro Leu Tyr Val Asn Ile Gly Lys Asp Lys Glu Ser 
785                 790                 795                 800 


Ser Val Ser Asp Pro Ala Val His Thr Ser Phe Gly Asn Thr Asp Gly 
                805                 810                 815     


Asp Glu Thr Ile Ala Gly Ala Ala Ala Ala Ala Ile Thr Ser Asp Tyr 
            820                 825                 830         


Arg Tyr Ile Met Ser Pro Leu Cys Leu Gly Asp Asp Val Glu Gly Glu 
        835                 840                 845             


Arg His Pro Glu Gly Gln Glu Gly Glu Asn Lys Ser Leu Leu Tyr Glu 
    850                 855                 860                 


Leu Glu Thr Glu Gly Glu Lys Ser Cys 
865                 870             


<210>  11
<211>  4510
<212>  DNA
<213>  Bos taurus


<220>
<221>  CDS
<222>  (1)..(3012)

<400>  11
atg gga cag aca gac agg aga cgc gga ggg cta ggg gct ggg ctt gac       48
Met Gly Gln Thr Asp Arg Arg Arg Gly Gly Leu Gly Ala Gly Leu Asp         
1               5                   10                  15              

ctg ggg gcc tcg cag aga ggg gct gag cgg agg ctc cct ccc atc tcc       96
Leu Gly Ala Ser Gln Arg Gly Ala Glu Arg Arg Leu Pro Pro Ile Ser         
            20                  25                  30                  

ttt tct tcc cca cca tcc acc agc cca gtc tgt gaa gtc tct aga gac      144
Phe Ser Ser Pro Pro Ser Thr Ser Pro Val Cys Glu Val Ser Arg Asp         
        35                  40                  45                      

cct aag cag ggg cag gcc agc cgg gca gtc agg gcg tgg gag gct gcc      192
Pro Lys Gln Gly Gln Ala Ser Arg Ala Val Arg Ala Trp Glu Ala Ala         
    50                  55                  60                          

aga tgc tgg gcc tac ttc cca acg gga tgg agg ccg gac ccc agt ccc      240
Arg Cys Trp Ala Tyr Phe Pro Thr Gly Trp Arg Pro Asp Pro Ser Pro         
65                  70                  75                  80          

ctg gga agg ctc cca tcc tcc tca cga agc ctc cac cct ccg ccc ccc      288
Leu Gly Arg Leu Pro Ser Ser Ser Arg Ser Leu His Pro Pro Pro Pro         
                85                  90                  95              

cag ctg agg tca ctc aac aac tat gtg ggc cta agg gcc tgg cgg ggt      336
Gln Leu Arg Ser Leu Asn Asn Tyr Val Gly Leu Arg Ala Trp Arg Gly         
            100                 105                 110                 

cct ggc agc cgt agg cag gcc ggc agg gat gga acc gag gag tcc agg      384
Pro Gly Ser Arg Arg Gln Ala Gly Arg Asp Gly Thr Glu Glu Ser Arg         
        115                 120                 125                     

gaa gca ggg gtt ccc aag cta atg ttc ttc cat ctc cct gca ggc cca      432
Glu Ala Gly Val Pro Lys Leu Met Phe Phe His Leu Pro Ala Gly Pro         
    130                 135                 140                         

cag act gaa gtg tcc ccc ttt gtg ggg agt ccg ggg aac atc acc ggt      480
Gln Thr Glu Val Ser Pro Phe Val Gly Ser Pro Gly Asn Ile Thr Gly         
145                 150                 155                 160         

gcc cga gga ctc atg ggc acc ctt cgg tgt gag ctc cag gtt cag ggg      528
Ala Arg Gly Leu Met Gly Thr Leu Arg Cys Glu Leu Gln Val Gln Gly         
                165                 170                 175             

gag ccc cct gag gtg acc tgg ctt cgg gat gga cag gtc cta gag ctg      576
Glu Pro Pro Glu Val Thr Trp Leu Arg Asp Gly Gln Val Leu Glu Leu         
            180                 185                 190                 

gca gac agc acc cag acc cag gtg ccc ctg ggc gaa gac ggg cag gat      624
Ala Asp Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Gly Gln Asp         
        195                 200                 205                     

gac tgg aaa gtg gtc agc caa ctc aga atc tcg tct ctg cag ctc tca      672
Asp Trp Lys Val Val Ser Gln Leu Arg Ile Ser Ser Leu Gln Leu Ser         
    210                 215                 220                         

gat gcg gga tgg tac cag tgc acc gtg gtc ctg gga gaa aag acc ttt      720
Asp Ala Gly Trp Tyr Gln Cys Thr Val Val Leu Gly Glu Lys Thr Phe         
225                 230                 235                 240         

gtg tct cag cct ggc tac gtg ggg ctg gaa ggc ctg cct tac ttc ctg      768
Val Ser Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu         
                245                 250                 255             

gag gag cct gag gac agg act gtg gtt gcc aac act ccc ttc aac ctg      816
Glu Glu Pro Glu Asp Arg Thr Val Val Ala Asn Thr Pro Phe Asn Leu         
            260                 265                 270                 

agc tgc cgg gcg cag gga ccc cca gag ccc gtg gac ctc ctc tgg ctc      864
Ser Cys Arg Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu         
        275                 280                 285                     

cag gat gct gtc tcc ctg gct tca gcc atg gac cac agc ccc cag cac      912
Gln Asp Ala Val Ser Leu Ala Ser Ala Met Asp His Ser Pro Gln His         
    290                 295                 300                         

aca ctc cgt gtt cca ggc ctg aac aag act gcg tct ttc tcc tgt gaa      960
Thr Leu Arg Val Pro Gly Leu Asn Lys Thr Ala Ser Phe Ser Cys Glu         
305                 310                 315                 320         

gcc cac aat gcc aag ggg atc acc aca tcc cgc acg gcc acc atc aca     1008
Ala His Asn Ala Lys Gly Ile Thr Thr Ser Arg Thr Ala Thr Ile Thr         
                325                 330                 335             

gtg ctc ccc cag cgg ccc cac gac ctc cac ttg gtt tcc acc cag ccg     1056
Val Leu Pro Gln Arg Pro His Asp Leu His Leu Val Ser Thr Gln Pro         
            340                 345                 350                 

acg gaa ctg gag gtg gct tgg acc cca ggc ctg agt ggc atc tac ccc     1104
Thr Glu Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro         
        355                 360                 365                     

ctc acc cac tgc att ctg cag gct gtg ctg tca gat gac agg gtg ggc     1152
Leu Thr His Cys Ile Leu Gln Ala Val Leu Ser Asp Asp Arg Val Gly         
    370                 375                 380                         

gcc tgg ctg gga gag cca gac ccc cca gag gag ccc ctc acc tta caa     1200
Ala Trp Leu Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Leu Gln         
385                 390                 395                 400         

gca tcc gtt cct cct cat caa cta cgg ctg ggc agc ctc cat cct cac     1248
Ala Ser Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His         
                405                 410                 415             

acc cct tac cac ctc cgg gtg gcc tgt gtc agt agc cag ggc ccc tca     1296
Thr Pro Tyr His Leu Arg Val Ala Cys Val Ser Ser Gln Gly Pro Ser         
            420                 425                 430                 

ccc tgg acc cac tgg ctt cct gtg gag aca ccg gaa gga gaa tac tgg     1344
Pro Trp Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Glu Tyr Trp         
        435                 440                 445                     

agt ggg ttg cca tgc cct cct cca ggg aat ctt cct gac ccc aga gat     1392
Ser Gly Leu Pro Cys Pro Pro Pro Gly Asn Leu Pro Asp Pro Arg Asp         
    450                 455                 460                         

cca acc cac gtc tcc tgg atc aga ccc aaa tcc cct gca ttg caa ggt     1440
Pro Thr His Val Ser Trp Ile Arg Pro Lys Ser Pro Ala Leu Gln Gly         
465                 470                 475                 480         

gga ttc tta acc act gga cca cca ggg aca tcc cct cac act cct cct     1488
Gly Phe Leu Thr Thr Gly Pro Pro Gly Thr Ser Pro His Thr Pro Pro         
                485                 490                 495             

cca acg tcc act cct ttc atg tcc atc gca tgc ccc gtc cag ccc tgt     1536
Pro Thr Ser Thr Pro Phe Met Ser Ile Ala Cys Pro Val Gln Pro Cys         
            500                 505                 510                 

cca tca ccc aat gaa cct aca cct gcc tcc ctt caa cac cac ccc cct     1584
Pro Ser Pro Asn Glu Pro Thr Pro Ala Ser Leu Gln His His Pro Pro         
        515                 520                 525                     

ggg gac cca agg aac caa gac ctc cac cat gac ctg tct gcg tac ccc     1632
Gly Asp Pro Arg Asn Gln Asp Leu His His Asp Leu Ser Ala Tyr Pro         
    530                 535                 540                         

gtg aca gtg agt gaa ccc cca gcc ccc gcc ttc tcg tgg ccc tgg tgg     1680
Val Thr Val Ser Glu Pro Pro Ala Pro Ala Phe Ser Trp Pro Trp Trp         
545                 550                 555                 560         

tat gta ctg ctg gga gca gtg gtg gcc gcc gcc tgt gtc ctc atc ctg     1728
Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu         
                565                 570                 575             

gcc ctg ttc ctc ttc cac cgg cgg aag aag gag acc cgt tat gga gag     1776
Ala Leu Phe Leu Phe His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu         
            580                 585                 590                 

gtg ttt gaa cca acc gtg gag agg ggt gag ctg gtg gtc agg tac cgt     1824
Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg         
        595                 600                 605                     

gtt cgc aag tcc tac agt cgg agg acc act gaa gcc acc ttg aac agc     1872
Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser         
    610                 615                 620                         

ctc ggc atc agc gaa gag ctg aag gag aaa ctg cgg gat gtg atg gtg     1920
Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val         
625                 630                 635                 640         

gac cgg cat aag gtg gct ctg ggg aag acc ctg gga gag gga gag ttc     1968
Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe         
                645                 650                 655             

gga gct gtg atg gaa ggc cag ctc aac cag gac gac tcc gtc ctc aag     2016
Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Val Leu Lys         
            660                 665                 670                 

gtg gct gtg aag acc atg aag att gcc atc tgc aca agg tcg gag ctg     2064
Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu         
        675                 680                 685                     

gag gat ttc ctg agt gaa gcc gtc tgc atg aag gaa ttc gac cac ccc     2112
Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro         
    690                 695                 700                         

aac gtc atg agg ctc att ggc gtt tgt ttc cag ggt tct gaa cga gaa     2160
Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu         
705                 710                 715                 720         

ggc ttc ccg gcg ccc gtg gtc atc tta ccc ttc atg aaa cac gga gac     2208
Gly Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp         
                725                 730                 735             

cta cac agt ttc ctt ctc tat tcc cgg ctc ggg gac cag cca gtg ttc     2256
Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe         
            740                 745                 750                 

ctg ccc acc cag atg ctg gtg aag ttc atg gca gat att gcc agt ggc     2304
Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly         
        755                 760                 765                     

atg gag tat ctg agt acc aag aga ttc ata cac cgg gac ctg gct gct     2352
Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala         
    770                 775                 780                         

agg aat tgc atg ctg aat gag aac atg tcg gtg tgt gtg gct gac ttt     2400
Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe         
785                 790                 795                 800         

ggg ctc tcc aag aag atc tac aat ggg gac tac tac cgt cag gga cgc     2448
Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg         
                805                 810                 815             

atc gcc aag atg ccg gtc aag tgg att gcc atc gag agc ctg gcg gac     2496
Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp         
            820                 825                 830                 

cgt gtc tat acc agc aag agc gat gta tgg tcc ttt ggg gtg acg atg     2544
Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met         
        835                 840                 845                     

tgg gag att gcc acg cga ggg caa acc cca tat cca gga gtg gag aac     2592
Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn         
    850                 855                 860                         

agt gag att tat gac tac ctg cgc cag gga aac cgc ctg aag cag ccc     2640
Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro         
865                 870                 875                 880         

gtg gac tgt ctg gac gga ctg tac gcc ctg atg tcc cgg tgc tgg gag     2688
Val Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu         
                885                 890                 895             

cta aac ccc cgg gac cgg ccg agt ttt gca gag ctg cgg gaa gac ctg     2736
Leu Asn Pro Arg Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu         
            900                 905                 910                 

gag aat acg ctg aag gcc ctg ccc cct gct cag gag cca gac gaa atc     2784
Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile         
        915                 920                 925                     

ctc tat gtc aac atg gat gag ggt gga ggt cat tct gaa cca ctt gga     2832
Leu Tyr Val Asn Met Asp Glu Gly Gly Gly His Ser Glu Pro Leu Gly         
    930                 935                 940                         

gct gct gga gga gcg gac ccc cca gct cag cct gac cct aag gat tcc     2880
Ala Ala Gly Gly Ala Asp Pro Pro Ala Gln Pro Asp Pro Lys Asp Ser         
945                 950                 955                 960         

tgc agc tgc ctc acc gcc gct gaa gtc cat cct gcc ggc cgc tat gtc     2928
Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val         
                965                 970                 975             

ctc tgc cct tct aca gcc cct ggc ccc atc ctg cct gct gaa agg agc     2976
Leu Cys Pro Ser Thr Ala Pro Gly Pro Ile Leu Pro Ala Glu Arg Ser         
            980                 985                 990                 

tcc cca gca ccc ccg ggg cag gag  gac ggc gcc tga gaccaccctc         3022
Ser Pro Ala Pro Pro Gly Gln Glu  Asp Gly Ala                            
        995                 1000                                        

cacctgggac ttcctctcag gacccaagct aggcactgcc actgggggac ggccccctac   3082

tttcccactc cagaccctac ccccaaccat agccctctct tcctacctgt tccacttcca   3142

tcccagacag atcctctccc ttttccatac cttagtgtcc ccatgcgtaa aagaaaggga   3202

ttagactgaa atccctgagg gccctcccag gtttaacatt ccaagattct agattctaag   3262

gtttaaagag tctagattca cagggtctaa gtttcagagc tgaatctttg agtctaaaga   3322

ctttgaattc cagtctctaa ttctaaagtg ctaaggttct agacatggaa gttctaaggc   3382

ctacattcta aggctctgag atgctgtggc tctagatttt tctggttctg agattcttca   3442

taaagcccat gaaattttag gttacaaagc tctaagattc tatttctaga atctaaggct   3502

ctgtgatttt agatttttat ttttctaggg ttttaagtcc tgagggtgta agatactaga   3562

tcctacaatt ctaaaaatcc tacagttcta gacatggagg ttctaaggcc ttatgttcta   3622

aaatttgaag ttctgggcct cttagagtat aacttttctg gttttaagac tccagatcat   3682

aagccacaag atttgatctt ctcaagttct aagattctaa tgatggtcag tgacagagtc   3742

taaggcttta tgatccttga aacccttgtt atgagactgt ggatcctaaa gatctaaaat   3802

gctagcatct gcaattcaaa agttctaata gtctaaagat ggaggttcta aggtctaatg   3862

ttctaagatg tgatgttcta aggcttagtc taagaaccta gagtctctgt gtctaagatt   3922

ccagatcata tgcttcaaga ttctagatta ttaaactcta agattctaat gttgttctgt   3982

tctgtgttcc aaggcattct agatcctatt ggtccaagat tctggatcct cagcatctat   4042

ggtatagata ttccacggtt agtggtgaca aactggatgc caaagttcta atcattttta   4102

atttcggaca cctttaagtt ctatgctgca tcttctcttt ccaggatttt agttaagggt   4162

ctaggaattc atggttctaa gttttacgat tctgggttcc aagattcaca tgttataaga   4222

ttctaaaggt ctagaattcc aaagtaaaat tctgaggttc taaccttata gttttatcct   4282

gtgtgaccct tcccttctta gccacctctg cttcctcttc ctttcatgtg ggggcgtgcc   4342

ccctcaaacc tgtgcaatgc aataaagacg cctcctttcc ccagaggaca atatccctct   4402

tttgggggcc atattgcccc cctgagccag tcctttatgc ctcctgaaca gagtgtgaac   4462

cctggcacct ccagtggggc tcagatcaca taaaactttg taaccatg                4510


<210>  12
<211>  1003
<212>  PRT
<213>  Bos taurus

<400>  12

Met Gly Gln Thr Asp Arg Arg Arg Gly Gly Leu Gly Ala Gly Leu Asp 
1               5                   10                  15      


Leu Gly Ala Ser Gln Arg Gly Ala Glu Arg Arg Leu Pro Pro Ile Ser 
            20                  25                  30          


Phe Ser Ser Pro Pro Ser Thr Ser Pro Val Cys Glu Val Ser Arg Asp 
        35                  40                  45              


Pro Lys Gln Gly Gln Ala Ser Arg Ala Val Arg Ala Trp Glu Ala Ala 
    50                  55                  60                  


Arg Cys Trp Ala Tyr Phe Pro Thr Gly Trp Arg Pro Asp Pro Ser Pro 
65                  70                  75                  80  


Leu Gly Arg Leu Pro Ser Ser Ser Arg Ser Leu His Pro Pro Pro Pro 
                85                  90                  95      


Gln Leu Arg Ser Leu Asn Asn Tyr Val Gly Leu Arg Ala Trp Arg Gly 
            100                 105                 110         


Pro Gly Ser Arg Arg Gln Ala Gly Arg Asp Gly Thr Glu Glu Ser Arg 
        115                 120                 125             


Glu Ala Gly Val Pro Lys Leu Met Phe Phe His Leu Pro Ala Gly Pro 
    130                 135                 140                 


Gln Thr Glu Val Ser Pro Phe Val Gly Ser Pro Gly Asn Ile Thr Gly 
145                 150                 155                 160 


Ala Arg Gly Leu Met Gly Thr Leu Arg Cys Glu Leu Gln Val Gln Gly 
                165                 170                 175     


Glu Pro Pro Glu Val Thr Trp Leu Arg Asp Gly Gln Val Leu Glu Leu 
            180                 185                 190         


Ala Asp Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Gly Gln Asp 
        195                 200                 205             


Asp Trp Lys Val Val Ser Gln Leu Arg Ile Ser Ser Leu Gln Leu Ser 
    210                 215                 220                 


Asp Ala Gly Trp Tyr Gln Cys Thr Val Val Leu Gly Glu Lys Thr Phe 
225                 230                 235                 240 


Val Ser Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu 
                245                 250                 255     


Glu Glu Pro Glu Asp Arg Thr Val Val Ala Asn Thr Pro Phe Asn Leu 
            260                 265                 270         


Ser Cys Arg Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu 
        275                 280                 285             


Gln Asp Ala Val Ser Leu Ala Ser Ala Met Asp His Ser Pro Gln His 
    290                 295                 300                 


Thr Leu Arg Val Pro Gly Leu Asn Lys Thr Ala Ser Phe Ser Cys Glu 
305                 310                 315                 320 


Ala His Asn Ala Lys Gly Ile Thr Thr Ser Arg Thr Ala Thr Ile Thr 
                325                 330                 335     


Val Leu Pro Gln Arg Pro His Asp Leu His Leu Val Ser Thr Gln Pro 
            340                 345                 350         


Thr Glu Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro 
        355                 360                 365             


Leu Thr His Cys Ile Leu Gln Ala Val Leu Ser Asp Asp Arg Val Gly 
    370                 375                 380                 


Ala Trp Leu Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Leu Gln 
385                 390                 395                 400 


Ala Ser Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His 
                405                 410                 415     


Thr Pro Tyr His Leu Arg Val Ala Cys Val Ser Ser Gln Gly Pro Ser 
            420                 425                 430         


Pro Trp Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Glu Tyr Trp 
        435                 440                 445             


Ser Gly Leu Pro Cys Pro Pro Pro Gly Asn Leu Pro Asp Pro Arg Asp 
    450                 455                 460                 


Pro Thr His Val Ser Trp Ile Arg Pro Lys Ser Pro Ala Leu Gln Gly 
465                 470                 475                 480 


Gly Phe Leu Thr Thr Gly Pro Pro Gly Thr Ser Pro His Thr Pro Pro 
                485                 490                 495     


Pro Thr Ser Thr Pro Phe Met Ser Ile Ala Cys Pro Val Gln Pro Cys 
            500                 505                 510         


Pro Ser Pro Asn Glu Pro Thr Pro Ala Ser Leu Gln His His Pro Pro 
        515                 520                 525             


Gly Asp Pro Arg Asn Gln Asp Leu His His Asp Leu Ser Ala Tyr Pro 
    530                 535                 540                 


Val Thr Val Ser Glu Pro Pro Ala Pro Ala Phe Ser Trp Pro Trp Trp 
545                 550                 555                 560 


Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu 
                565                 570                 575     


Ala Leu Phe Leu Phe His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu 
            580                 585                 590         


Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg 
        595                 600                 605             


Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser 
    610                 615                 620                 


Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val 
625                 630                 635                 640 


Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe 
                645                 650                 655     


Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Val Leu Lys 
            660                 665                 670         


Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu 
        675                 680                 685             


Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro 
    690                 695                 700                 


Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu 
705                 710                 715                 720 


Gly Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp 
                725                 730                 735     


Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe 
            740                 745                 750         


Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly 
        755                 760                 765             


Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala 
    770                 775                 780                 


Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe 
785                 790                 795                 800 


Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg 
                805                 810                 815     


Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp 
            820                 825                 830         


Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met 
        835                 840                 845             


Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn 
    850                 855                 860                 


Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro 
865                 870                 875                 880 


Val Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu 
                885                 890                 895     


Leu Asn Pro Arg Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu 
            900                 905                 910         


Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile 
        915                 920                 925             


Leu Tyr Val Asn Met Asp Glu Gly Gly Gly His Ser Glu Pro Leu Gly 
    930                 935                 940                 


Ala Ala Gly Gly Ala Asp Pro Pro Ala Gln Pro Asp Pro Lys Asp Ser 
945                 950                 955                 960 


Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val 
                965                 970                 975     


Leu Cys Pro Ser Thr Ala Pro Gly Pro Ile Leu Pro Ala Glu Arg Ser 
            980                 985                 990         


Ser Pro Ala Pro Pro Gly Gln Glu  Asp Gly Ala 
        995                 1000             


<210>  13
<211>  2664
<212>  DNA
<213>  Canis familiaris


<220>
<221>  CDS
<222>  (1)..(2664)

<400>  13
atg ggc agg gtc ccg ctg gcc tgg tgc ttg gcg ctg tgc tgc tgg ggg       48
Met Gly Arg Val Pro Leu Ala Trp Cys Leu Ala Leu Cys Cys Trp Gly         
1               5                   10                  15              

tgc ctg gcc ccc ccg ggc aca cag gct gag gca gac ccc ttt gtg ggg       96
Cys Leu Ala Pro Pro Gly Thr Gln Ala Glu Ala Asp Pro Phe Val Gly         
            20                  25                  30                  

agt cca agg aac atc acc ggt gcc cga gga ctc acc ggg gcc ctt cgg      144
Ser Pro Arg Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Ala Leu Arg         
        35                  40                  45                      

tgt gag ctc cag gtt cag ggg gag ccc cct gag gtg acg tgg ctt cgg      192
Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Thr Trp Leu Arg         
    50                  55                  60                          

gat gga cag gtg ctg gag ctg gcg gac agt acc cag acc cag gtg ccc      240
Asp Gly Gln Val Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val Pro         
65                  70                  75                  80          

ctg ggt gaa gac ggg cag gat gac tgg aag gtg gtc agc caa ctc aga      288
Leu Gly Glu Asp Gly Gln Asp Asp Trp Lys Val Val Ser Gln Leu Arg         
                85                  90                  95              

atc tca tcc ctg cag ctc tca gac gcc ggg tgg tac caa tgt gcc gtg      336
Ile Ser Ser Leu Gln Leu Ser Asp Ala Gly Trp Tyr Gln Cys Ala Val         
            100                 105                 110                 

gtc ctg gga gga aag acc ttc gtg tcg cag cct ggc tac gtt ggg ctg      384
Val Leu Gly Gly Lys Thr Phe Val Ser Gln Pro Gly Tyr Val Gly Leu         
        115                 120                 125                     

gag ggc ctg cct tac ttc ctg gag gag ccc gag gac aga acc gtg gcc      432
Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala         
    130                 135                 140                         

gcc aat acc ccc ttt aac ctg agc tgc cgg gct gag gga ccc cca gag      480
Ala Asn Thr Pro Phe Asn Leu Ser Cys Arg Ala Glu Gly Pro Pro Glu         
145                 150                 155                 160         

cct gtg gat cta ctc tgg ctc cag gat gcc gtc ccc cta cct cta gcc      528
Pro Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Pro Leu Ala         
                165                 170                 175             

gcg acc cac agt gcc cag cac acg ctg cgc att cca ggc ttg aac aag      576
Ala Thr His Ser Ala Gln His Thr Leu Arg Ile Pro Gly Leu Asn Lys         
            180                 185                 190                 

aca tct tct ttc tcc tgt gaa gcc cat aat gcc aag ggg gtc acc aca      624
Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr         
        195                 200                 205                     

tcc cgc aca gcc acc atc aca gtg ctc ccc cag cgg ccc cgc aac ctc      672
Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro Arg Asn Leu         
    210                 215                 220                         

cac ctg gtt tcc cgc cag ccc aca gag ctg gag gtg gct tgg act cca      720
His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr Pro         
225                 230                 235                 240         

ggc ctg agt ggc atc tat ccc ctc acg cac tgc acc ctg cag cct caa      768
Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Pro Gln         
                245                 250                 255             

gtc cca cca gat gtc ctg ggt tca aat cct gac tcc ccc aac ccc ccg      816
Val Pro Pro Asp Val Leu Gly Ser Asn Pro Asp Ser Pro Asn Pro Pro         
            260                 265                 270                 

gag gag cct ctc acc ttg caa gcg ttt gtc ccc cct cac caa ctt cgg      864
Glu Glu Pro Leu Thr Leu Gln Ala Phe Val Pro Pro His Gln Leu Arg         
        275                 280                 285                     

gtg ggc agc ctc cat cct cac act cct tac cac atc cgg gtg gcc tgt      912
Val Gly Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala Cys         
    290                 295                 300                         

acc agt agc cag ggg ccc tca ccc tgg acc cac tgg ctt cct gtg gag      960
Thr Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val Glu         
305                 310                 315                 320         

aca cca gag gga gtg ccc ctg ggt ccc ccc gag aac gtt agc gcc ttg     1008
Thr Pro Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala Leu         
                325                 330                 335             

cgg aat ggg agc caa gcc ctc gtg cgt tgg cag gag cca agg gcg ccc     1056
Arg Asn Gly Ser Gln Ala Leu Val Arg Trp Gln Glu Pro Arg Ala Pro         
            340                 345                 350                 

ctg cag ggc acc ctg tta ggg tac cgg ctg gcc tac cga ggc cag gac     1104
Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln Asp         
        355                 360                 365                     

acc ccc gag gtg ctc atg gac ata ggg cta aag aga gag gtg acc ctg     1152
Thr Pro Glu Val Leu Met Asp Ile Gly Leu Lys Arg Glu Val Thr Leu         
    370                 375                 380                         

gag ctg caa ggg gat ggg acg gtg ccc aac ctg aca gtg tgt gtg gca     1200
Glu Leu Gln Gly Asp Gly Thr Val Pro Asn Leu Thr Val Cys Val Ala         
385                 390                 395                 400         

gcc tac act gct gct ggg gat gga ccc tgg agc ctc cct gtg ccc ctg     1248
Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu         
                405                 410                 415             

gag ccc tgg cgc cca ggg caa gga caa cca atc cac cag ctg gtg agt     1296
Glu Pro Trp Arg Pro Gly Gln Gly Gln Pro Ile His Gln Leu Val Ser         
            420                 425                 430                 

gag ccc cca gcc cct gcc ttc tca tgg ccc tgg tgg tat gta ttg ctg     1344
Glu Pro Pro Ala Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu         
        435                 440                 445                     

gga gca gtc gtg gct gcc ggt tgt gtc ctc atc ttg gcc ctg ttc ctt     1392
Gly Ala Val Val Ala Ala Gly Cys Val Leu Ile Leu Ala Leu Phe Leu         
    450                 455                 460                         

gtc cac cgg cgg aag aag gag acc cgc tat gga gag gtg ttt gaa cca     1440
Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro         
465                 470                 475                 480         

aca gtg gag agg ggt gag ctg gtg gtt agg tac cgt gtt cgc aag tcc     1488
Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser         
                485                 490                 495             

tac agt cgc cgg acc act gaa gcc acc ttg aac agc ctg ggc atc agt     1536
Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser         
            500                 505                 510                 

gaa gag ctg aag gag aag ctt cgg gat gtg atg gtg gac cgg cat aag     1584
Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys         
        515                 520                 525                     

gtg gcg ctg ggg aag acc ctg gga gaa gga gaa ttt gga gca gtg atg     1632
Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met         
    530                 535                 540                         

gag ggc cag ctc aac cag gat gac tct atc ctc aag gtg gct gtg aag     1680
Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys         
545                 550                 555                 560         

aca atg aag att gct atc tgc aca agg tcg gag ctg gag gat ttc ctg     1728
Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu         
                565                 570                 575             

agt gaa gct gtc tgc atg aag gaa ttt gac cac ccc aac gtg atg agg     1776
Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg         
            580                 585                 590                 

ctc att ggc gtc tgt ttc cag ggt tcc gaa cga gag ggc ttc ccg gca     1824
Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Gly Phe Pro Ala         
        595                 600                 605                     

ccg gtg gtc atc tta cct ttc atg aag cat gga gac ctg cac agt ttc     1872
Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe         
    610                 615                 620                         

ctt ctc tat tcc cgg ctt ggg gac cag cca gtg ttc ctg ccc act cag     1920
Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe Leu Pro Thr Gln         
625                 630                 635                 640         

atg ctg gtg aag ttc atg gca gac atc gcc agt ggc atg gag tat ctg     1968
Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu         
                645                 650                 655             

agt acc aag aga ttc ata cac cga gac ctg gcc gcc agg aac tgc atg     2016
Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met         
            660                 665                 670                 

ctg aat gag aac atg tcc gtg tgt gtg gcg gat ttt ggg ctt tcc aag     2064
Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys         
        675                 680                 685                     

aag atc tac aat ggg gac tac tac cgc cag gga cgc atc gcc aag atg     2112
Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met         
    690                 695                 700                         

cca gtc aag tgg att gcc att gag agc ctg gct gac cgt gtc tac acc     2160
Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr         
705                 710                 715                 720         

agc aag agt gat gtg tgg tcc ttt ggg gtg acg atg tgg gag att gct     2208
Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala         
                725                 730                 735             

aca cgg ggc caa acc cca tat cca gga gtg gaa aac agc gag att tac     2256
Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr         
            740                 745                 750                 

gac tac ctg tgc cag gga aat cga cta aag cag cct gtg ggc tgt ctg     2304
Asp Tyr Leu Cys Gln Gly Asn Arg Leu Lys Gln Pro Val Gly Cys Leu         
        755                 760                 765                     

gat gga ctg tat gcc ctg atg tcc cgg tgc tgg gag cta aac ccc cgg     2352
Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Arg         
    770                 775                 780                         

gac cgg ccg agt ttc tca gag ctt cgg gaa gat ctg gag aac aca ctg     2400
Asp Arg Pro Ser Phe Ser Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu         
785                 790                 795                 800         

aaa gcc ctg ccc cct gcc cag gag ccc gag gaa atc ctc tat gtc aac     2448
Lys Ala Leu Pro Pro Ala Gln Glu Pro Glu Glu Ile Leu Tyr Val Asn         
                805                 810                 815             

atg gat gag ggt ggg agt cat tct gaa cca ctt gga gct gct gga gga     2496
Met Asp Glu Gly Gly Ser His Ser Glu Pro Leu Gly Ala Ala Gly Gly         
            820                 825                 830                 

gct gac ccc cca act cag cct gac ccc aag gat tcc tgc agt tgc ctc     2544
Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu         
        835                 840                 845                     

acc gcg gct gag gtc cat cct gct gga cgc tat gtc ctc tgc cct tct     2592
Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser         
    850                 855                 860                         

aca gcc cct ggc ccc gcc ctg cct act gac agg agc tcc cca gct cct     2640
Thr Ala Pro Gly Pro Ala Leu Pro Thr Asp Arg Ser Ser Pro Ala Pro         
865                 870                 875                 880         

cca ggg cag gag gat gga gcc tga                                     2664
Pro Gly Gln Glu Asp Gly Ala                                             
                885                                                     


<210>  14
<211>  887
<212>  PRT
<213>  Canis familiaris

<400>  14

Met Gly Arg Val Pro Leu Ala Trp Cys Leu Ala Leu Cys Cys Trp Gly 
1               5                   10                  15      


Cys Leu Ala Pro Pro Gly Thr Gln Ala Glu Ala Asp Pro Phe Val Gly 
            20                  25                  30          


Ser Pro Arg Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Ala Leu Arg 
        35                  40                  45              


Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Thr Trp Leu Arg 
    50                  55                  60                  


Asp Gly Gln Val Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val Pro 
65                  70                  75                  80  


Leu Gly Glu Asp Gly Gln Asp Asp Trp Lys Val Val Ser Gln Leu Arg 
                85                  90                  95      


Ile Ser Ser Leu Gln Leu Ser Asp Ala Gly Trp Tyr Gln Cys Ala Val 
            100                 105                 110         


Val Leu Gly Gly Lys Thr Phe Val Ser Gln Pro Gly Tyr Val Gly Leu 
        115                 120                 125             


Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala 
    130                 135                 140                 


Ala Asn Thr Pro Phe Asn Leu Ser Cys Arg Ala Glu Gly Pro Pro Glu 
145                 150                 155                 160 


Pro Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Pro Leu Ala 
                165                 170                 175     


Ala Thr His Ser Ala Gln His Thr Leu Arg Ile Pro Gly Leu Asn Lys 
            180                 185                 190         


Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr 
        195                 200                 205             


Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro Arg Asn Leu 
    210                 215                 220                 


His Leu Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr Pro 
225                 230                 235                 240 


Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Pro Gln 
                245                 250                 255     


Val Pro Pro Asp Val Leu Gly Ser Asn Pro Asp Ser Pro Asn Pro Pro 
            260                 265                 270         


Glu Glu Pro Leu Thr Leu Gln Ala Phe Val Pro Pro His Gln Leu Arg 
        275                 280                 285             


Val Gly Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala Cys 
    290                 295                 300                 


Thr Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val Glu 
305                 310                 315                 320 


Thr Pro Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala Leu 
                325                 330                 335     


Arg Asn Gly Ser Gln Ala Leu Val Arg Trp Gln Glu Pro Arg Ala Pro 
            340                 345                 350         


Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln Asp 
        355                 360                 365             


Thr Pro Glu Val Leu Met Asp Ile Gly Leu Lys Arg Glu Val Thr Leu 
    370                 375                 380                 


Glu Leu Gln Gly Asp Gly Thr Val Pro Asn Leu Thr Val Cys Val Ala 
385                 390                 395                 400 


Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu 
                405                 410                 415     


Glu Pro Trp Arg Pro Gly Gln Gly Gln Pro Ile His Gln Leu Val Ser 
            420                 425                 430         


Glu Pro Pro Ala Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu 
        435                 440                 445             


Gly Ala Val Val Ala Ala Gly Cys Val Leu Ile Leu Ala Leu Phe Leu 
    450                 455                 460                 


Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
465                 470                 475                 480 


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
                485                 490                 495     


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
            500                 505                 510         


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
        515                 520                 525             


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
    530                 535                 540                 


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
545                 550                 555                 560 


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
                565                 570                 575     


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
            580                 585                 590         


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Gly Phe Pro Ala 
        595                 600                 605             


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
    610                 615                 620                 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Phe Leu Pro Thr Gln 
625                 630                 635                 640 


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
                645                 650                 655     


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
            660                 665                 670         


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
        675                 680                 685             


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
    690                 695                 700                 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
705                 710                 715                 720 


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
                725                 730                 735     


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
            740                 745                 750         


Asp Tyr Leu Cys Gln Gly Asn Arg Leu Lys Gln Pro Val Gly Cys Leu 
        755                 760                 765             


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Arg 
    770                 775                 780                 


Asp Arg Pro Ser Phe Ser Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
785                 790                 795                 800 


Lys Ala Leu Pro Pro Ala Gln Glu Pro Glu Glu Ile Leu Tyr Val Asn 
                805                 810                 815     


Met Asp Glu Gly Gly Ser His Ser Glu Pro Leu Gly Ala Ala Gly Gly 
            820                 825                 830         


Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu 
        835                 840                 845             


Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser 
    850                 855                 860                 


Thr Ala Pro Gly Pro Ala Leu Pro Thr Asp Arg Ser Ser Pro Ala Pro 
865                 870                 875                 880 


Pro Gly Gln Glu Asp Gly Ala 
                885         


<210>  15
<211>  2682
<212>  DNA
<213>  Danio rerio


<220>
<221>  CDS
<222>  (1)..(2682)

<400>  15
atg cag ctt gga aag ccc cat gca cac cca gtc tac cat gct tgt aac       48
Met Gln Leu Gly Lys Pro His Ala His Pro Val Tyr His Ala Cys Asn         
1               5                   10                  15              

cct aaa ttc aaa aag aaa tct aaa aaa tta ttg aca aaa tgg atc cca       96
Pro Lys Phe Lys Lys Lys Ser Lys Lys Leu Leu Thr Lys Trp Ile Pro         
            20                  25                  30                  

aaa caa gat gcc cgt gag ctt ctg ctg gac ctg agt ttt gcc caa gtg      144
Lys Gln Asp Ala Arg Glu Leu Leu Leu Asp Leu Ser Phe Ala Gln Val         
        35                  40                  45                      

gac cag cag cct ctt tac atc ttt gtt att aaa tct aac cag tct cag      192
Asp Gln Gln Pro Leu Tyr Ile Phe Val Ile Lys Ser Asn Gln Ser Gln         
    50                  55                  60                          

aag cca tat gga cca caa aaa cca gtt ctt gca atc aca gtc cag cat      240
Lys Pro Tyr Gly Pro Gln Lys Pro Val Leu Ala Ile Thr Val Gln His         
65                  70                  75                  80          

cca ttc ctt gca aac ggc tat cct cgg gat gag gac ctg agt cat gcc      288
Pro Phe Leu Ala Asn Gly Tyr Pro Arg Asp Glu Asp Leu Ser His Ala         
                85                  90                  95              

aag gct cta aat ttg gga aac atc tct gag aac ggc ttt tac ctg gcg      336
Lys Ala Leu Asn Leu Gly Asn Ile Ser Glu Asn Gly Phe Tyr Leu Ala         
            100                 105                 110                 

ttt tta tac agc gga aac tgc atg ttc att gct tca gtc cag gtg ttc      384
Phe Leu Tyr Ser Gly Asn Cys Met Phe Ile Ala Ser Val Gln Val Phe         
        115                 120                 125                     

ttc ctc aaa tgt cca gct ttt gca tgg aag cag atg aag ttt gag gaa      432
Phe Leu Lys Cys Pro Ala Phe Ala Trp Lys Gln Met Lys Phe Glu Glu         
    130                 135                 140                         

act gca gca gga ggg tcg agg aga gga gtg tgt gtg gat gga gca gtg      480
Thr Ala Ala Gly Gly Ser Arg Arg Gly Val Cys Val Asp Gly Ala Val         
145                 150                 155                 160         

gag att tcg acc ccg ctg act gag tgt cag tct aat ggg aca tgg gct      528
Glu Ile Ser Thr Pro Leu Thr Glu Cys Gln Ser Asn Gly Thr Trp Ala         
                165                 170                 175             

tca ccg caa ggc tca ggt gtc ggc agg gca gaa tac cag agc agt gga      576
Ser Pro Gln Gly Ser Gly Val Gly Arg Ala Glu Tyr Gln Ser Ser Gly         
            180                 185                 190                 

gac aca ggc aaa ggt gag gaa gtg ttt tat gtg ttt aac agt gcc ctt      624
Asp Thr Gly Lys Gly Glu Glu Val Phe Tyr Val Phe Asn Ser Ala Leu         
        195                 200                 205                     

aga ggg cca cct ctg atg tac att att gat tac att gcg caa atg tcc      672
Arg Gly Pro Pro Leu Met Tyr Ile Ile Asp Tyr Ile Ala Gln Met Ser         
    210                 215                 220                         

act att ggt gga aca gct gaa tgg aat gct cta aac cag ggg gtt gat      720
Thr Ile Gly Gly Thr Ala Glu Trp Asn Ala Leu Asn Gln Gly Val Asp         
225                 230                 235                 240         

gag att ctt ctt acc tac aac tgg tgg ccc gag tgc aat tcc aaa ccc      768
Glu Ile Leu Leu Thr Tyr Asn Trp Trp Pro Glu Cys Asn Ser Lys Pro         
                245                 250                 255             

tcc aaa gca cat gag aat ccc atg cgc ctg acc aag ccg ttc aat gcc      816
Ser Lys Ala His Glu Asn Pro Met Arg Leu Thr Lys Pro Phe Asn Ala         
            260                 265                 270                 

cac aat ctt ggt agt gat tct gga tct gat ctc aaa acc aaa ccc ggc      864
His Asn Leu Gly Ser Asp Ser Gly Ser Asp Leu Lys Thr Lys Pro Gly         
        275                 280                 285                     

tta gcc gaa aac act acc aca gtg aaa ctg ttg atc aac aaa gac ccc      912
Leu Ala Glu Asn Thr Thr Thr Val Lys Leu Leu Ile Asn Lys Asp Pro         
    290                 295                 300                         

aca gag cta caa gac agt gaa gga gaa cgg aaa gtc cac ata ttg tcc      960
Thr Glu Leu Gln Asp Ser Glu Gly Glu Arg Lys Val His Ile Leu Ser         
305                 310                 315                 320         

agt tca ata ata gca cga gcc att aag aag tgg atg cgt cca tat gga     1008
Ser Ser Ile Ile Ala Arg Ala Ile Lys Lys Trp Met Arg Pro Tyr Gly         
                325                 330                 335             

cag tat ttc tgc gaa aca gta gag ctc cta cag gac cgg gtc ttc atg     1056
Gln Tyr Phe Cys Glu Thr Val Glu Leu Leu Gln Asp Arg Val Phe Met         
            340                 345                 350                 

gct ttc tgt atc gcc atg ttt ctg ttt agc tta gga gca ttt cca cct     1104
Ala Phe Cys Ile Ala Met Phe Leu Phe Ser Leu Gly Ala Phe Pro Pro         
        355                 360                 365                     

gtg ctc ttc atg gag gac gtg gcc cag agc gaa ggg ctt att gat ggg     1152
Val Leu Phe Met Glu Asp Val Ala Gln Ser Glu Gly Leu Ile Asp Gly         
    370                 375                 380                         

att gcg ctg ata cca ctg gtc tcc att gtt gcg atg act aca ggc atc     1200
Ile Ala Leu Ile Pro Leu Val Ser Ile Val Ala Met Thr Thr Gly Ile         
385                 390                 395                 400         

ggt aag ctg att ctg ggt gtg ctg gcc gac atg cga tgg gtc aac agt     1248
Gly Lys Leu Ile Leu Gly Val Leu Ala Asp Met Arg Trp Val Asn Ser         
                405                 410                 415             

ctg tat ctg tac gcc ctg aca ctc att ggc tct gga acg gct ctg ctt     1296
Leu Tyr Leu Tyr Ala Leu Thr Leu Ile Gly Ser Gly Thr Ala Leu Leu         
            420                 425                 430                 

ctc atc cct gtg tcc aag agc tat ttg ggt cta cag att ctt tca gcc     1344
Leu Ile Pro Val Ser Lys Ser Tyr Leu Gly Leu Gln Ile Leu Ser Ala         
        435                 440                 445                     

gct gtt ggg ttt ttc tca ggg aac tgg tct ctt aca tca tac atc act     1392
Ala Val Gly Phe Phe Ser Gly Asn Trp Ser Leu Thr Ser Tyr Ile Thr         
    450                 455                 460                         

acc aag att gtg ggc att gaa cgg ctt ggt cag gcg cat ggg att ctc     1440
Thr Lys Ile Val Gly Ile Glu Arg Leu Gly Gln Ala His Gly Ile Leu         
465                 470                 475                 480         

atg tgc ttt gga ggg ttt gga att gca ctc ggg cca cca gtt gta gtg     1488
Met Cys Phe Gly Gly Phe Gly Ile Ala Leu Gly Pro Pro Val Val Val         
                485                 490                 495             

tca gac tca gat cag atg ttg gat ggg ata aag gat cat ctg ctg tgt     1536
Ser Asp Ser Asp Gln Met Leu Asp Gly Ile Lys Asp His Leu Leu Cys         
            500                 505                 510                 

ctt aga gat gtg ctg gtg gaa cgg aca aag tta caa tta agc caa aaa     1584
Leu Arg Asp Val Leu Val Glu Arg Thr Lys Leu Gln Leu Ser Gln Lys         
        515                 520                 525                     

ctt ggg aaa ggg gaa ttt gga gct gtt tat gag ggc ata ttt tcc cct     1632
Leu Gly Lys Gly Glu Phe Gly Ala Val Tyr Glu Gly Ile Phe Ser Pro         
    530                 535                 540                         

aaa ata gga caa gac atc aga gtt gcg gtc aaa aca tct aaa gac gtg     1680
Lys Ile Gly Gln Asp Ile Arg Val Ala Val Lys Thr Ser Lys Asp Val         
545                 550                 555                 560         

atc cac agt gaa gaa gat ctg gag tct ttc ctg aag gag gcg gaa atg     1728
Ile His Ser Glu Glu Asp Leu Glu Ser Phe Leu Lys Glu Ala Glu Met         
                565                 570                 575             

atg aag cat ttc gat cat gtg aat gta gtt aaa ttg ctc ggt ttt agc     1776
Met Lys His Phe Asp His Val Asn Val Val Lys Leu Leu Gly Phe Ser         
            580                 585                 590                 

ccg aac ccg acc gct ccc gct tat gct cag cat tta ttg tcc cgc tgc     1824
Pro Asn Pro Thr Ala Pro Ala Tyr Ala Gln His Leu Leu Ser Arg Cys         
        595                 600                 605                     

ccg act cgc tct gtt ttc tac ccg ccg tgc ctg ttc ctg gta atg ggg     1872
Pro Thr Arg Ser Val Phe Tyr Pro Pro Cys Leu Phe Leu Val Met Gly         
    610                 615                 620                         

gtt gca cta gag tgg gat ccg gaa tct tct atg gtt gta cca ctg gtt     1920
Val Ala Leu Glu Trp Asp Pro Glu Ser Ser Met Val Val Pro Leu Val         
625                 630                 635                 640         

att ctc cca tac atg aag cac aga gac tta cac agt ttc ctc aga gcg     1968
Ile Leu Pro Tyr Met Lys His Arg Asp Leu His Ser Phe Leu Arg Ala         
                645                 650                 655             

aca aga tac gat gat gtt ccc atg ttt gtg cct cat cag agt ctt ctg     2016
Thr Arg Tyr Asp Asp Val Pro Met Phe Val Pro His Gln Ser Leu Leu         
            660                 665                 670                 

cgc ttt atg atg gac att gct gcg gga atg gag tat ctg agc ctt cag     2064
Arg Phe Met Met Asp Ile Ala Ala Gly Met Glu Tyr Leu Ser Leu Gln         
        675                 680                 685                     

ggt ttc tta cac aga gat ctg gcc gcc cgc aac tgc atg ttg ggt gat     2112
Gly Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Gly Asp         
    690                 695                 700                         

gat ctg cgt gtg tgt gtg gcg gac ttt ggc ctc tct aag atg atg tat     2160
Asp Leu Arg Val Cys Val Ala Asp Phe Gly Leu Ser Lys Met Met Tyr         
705                 710                 715                 720         

tcc agc aac tac tac aga cat aag agt cag gat gtt aaa ctg cct gtg     2208
Ser Ser Asn Tyr Tyr Arg His Lys Ser Gln Asp Val Lys Leu Pro Val         
                725                 730                 735             

agg tgg atg gcc ata gag agt gtg tca gac ttc ata ttc acc acc aag     2256
Arg Trp Met Ala Ile Glu Ser Val Ser Asp Phe Ile Phe Thr Thr Lys         
            740                 745                 750                 

agt gat gtg tgg tca ttt ggg gta acc atg tgg gag atc aca tct aga     2304
Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Thr Ser Arg         
        755                 760                 765                     

ggg aag gta cct tat cca ggt gtc tcc aat tac gag ctt ctg gac tac     2352
Gly Lys Val Pro Tyr Pro Gly Val Ser Asn Tyr Glu Leu Leu Asp Tyr         
    770                 775                 780                         

ctg gaa aaa gga cat cgg ctt agc caa ggg gac aat gac agc aaa cta     2400
Leu Glu Lys Gly His Arg Leu Ser Gln Gly Asp Asn Asp Ser Lys Leu         
785                 790                 795                 800         

tat gag ctt atg ttg agc tgc tgg cac aga gat cca tct cag aga cca     2448
Tyr Glu Leu Met Leu Ser Cys Trp His Arg Asp Pro Ser Gln Arg Pro         
                805                 810                 815             

agt ttt gga gag ctg cac cag agc ttc agt gct ctt ctg tct gag ctt     2496
Ser Phe Gly Glu Leu His Gln Ser Phe Ser Ala Leu Leu Ser Glu Leu         
            820                 825                 830                 

cca ctt ctg gag gac aga atg gag agc cac tac atc aac ctg ggc ctg     2544
Pro Leu Leu Glu Asp Arg Met Glu Ser His Tyr Ile Asn Leu Gly Leu         
        835                 840                 845                     

gag gct gcc aac gat cga cag gac agt gca caa aac cag gtg gaa aat     2592
Glu Ala Ala Asn Asp Arg Gln Asp Ser Ala Gln Asn Gln Val Glu Asn         
    850                 855                 860                         

aaa aca gac tat ctg gat ctg ctt aaa act ggt gag ggg ttt gag gaa     2640
Lys Thr Asp Tyr Leu Asp Leu Leu Lys Thr Gly Glu Gly Phe Glu Glu         
865                 870                 875                 880         

aga gaa gga aag tat aag gag gga gag caa aag tat atg tga             2682
Arg Glu Gly Lys Tyr Lys Glu Gly Glu Gln Lys Tyr Met                     
                885                 890                                 


<210>  16
<211>  893
<212>  PRT
<213>  Danio rerio

<400>  16

Met Gln Leu Gly Lys Pro His Ala His Pro Val Tyr His Ala Cys Asn 
1               5                   10                  15      


Pro Lys Phe Lys Lys Lys Ser Lys Lys Leu Leu Thr Lys Trp Ile Pro 
            20                  25                  30          


Lys Gln Asp Ala Arg Glu Leu Leu Leu Asp Leu Ser Phe Ala Gln Val 
        35                  40                  45              


Asp Gln Gln Pro Leu Tyr Ile Phe Val Ile Lys Ser Asn Gln Ser Gln 
    50                  55                  60                  


Lys Pro Tyr Gly Pro Gln Lys Pro Val Leu Ala Ile Thr Val Gln His 
65                  70                  75                  80  


Pro Phe Leu Ala Asn Gly Tyr Pro Arg Asp Glu Asp Leu Ser His Ala 
                85                  90                  95      


Lys Ala Leu Asn Leu Gly Asn Ile Ser Glu Asn Gly Phe Tyr Leu Ala 
            100                 105                 110         


Phe Leu Tyr Ser Gly Asn Cys Met Phe Ile Ala Ser Val Gln Val Phe 
        115                 120                 125             


Phe Leu Lys Cys Pro Ala Phe Ala Trp Lys Gln Met Lys Phe Glu Glu 
    130                 135                 140                 


Thr Ala Ala Gly Gly Ser Arg Arg Gly Val Cys Val Asp Gly Ala Val 
145                 150                 155                 160 


Glu Ile Ser Thr Pro Leu Thr Glu Cys Gln Ser Asn Gly Thr Trp Ala 
                165                 170                 175     


Ser Pro Gln Gly Ser Gly Val Gly Arg Ala Glu Tyr Gln Ser Ser Gly 
            180                 185                 190         


Asp Thr Gly Lys Gly Glu Glu Val Phe Tyr Val Phe Asn Ser Ala Leu 
        195                 200                 205             


Arg Gly Pro Pro Leu Met Tyr Ile Ile Asp Tyr Ile Ala Gln Met Ser 
    210                 215                 220                 


Thr Ile Gly Gly Thr Ala Glu Trp Asn Ala Leu Asn Gln Gly Val Asp 
225                 230                 235                 240 


Glu Ile Leu Leu Thr Tyr Asn Trp Trp Pro Glu Cys Asn Ser Lys Pro 
                245                 250                 255     


Ser Lys Ala His Glu Asn Pro Met Arg Leu Thr Lys Pro Phe Asn Ala 
            260                 265                 270         


His Asn Leu Gly Ser Asp Ser Gly Ser Asp Leu Lys Thr Lys Pro Gly 
        275                 280                 285             


Leu Ala Glu Asn Thr Thr Thr Val Lys Leu Leu Ile Asn Lys Asp Pro 
    290                 295                 300                 


Thr Glu Leu Gln Asp Ser Glu Gly Glu Arg Lys Val His Ile Leu Ser 
305                 310                 315                 320 


Ser Ser Ile Ile Ala Arg Ala Ile Lys Lys Trp Met Arg Pro Tyr Gly 
                325                 330                 335     


Gln Tyr Phe Cys Glu Thr Val Glu Leu Leu Gln Asp Arg Val Phe Met 
            340                 345                 350         


Ala Phe Cys Ile Ala Met Phe Leu Phe Ser Leu Gly Ala Phe Pro Pro 
        355                 360                 365             


Val Leu Phe Met Glu Asp Val Ala Gln Ser Glu Gly Leu Ile Asp Gly 
    370                 375                 380                 


Ile Ala Leu Ile Pro Leu Val Ser Ile Val Ala Met Thr Thr Gly Ile 
385                 390                 395                 400 


Gly Lys Leu Ile Leu Gly Val Leu Ala Asp Met Arg Trp Val Asn Ser 
                405                 410                 415     


Leu Tyr Leu Tyr Ala Leu Thr Leu Ile Gly Ser Gly Thr Ala Leu Leu 
            420                 425                 430         


Leu Ile Pro Val Ser Lys Ser Tyr Leu Gly Leu Gln Ile Leu Ser Ala 
        435                 440                 445             


Ala Val Gly Phe Phe Ser Gly Asn Trp Ser Leu Thr Ser Tyr Ile Thr 
    450                 455                 460                 


Thr Lys Ile Val Gly Ile Glu Arg Leu Gly Gln Ala His Gly Ile Leu 
465                 470                 475                 480 


Met Cys Phe Gly Gly Phe Gly Ile Ala Leu Gly Pro Pro Val Val Val 
                485                 490                 495     


Ser Asp Ser Asp Gln Met Leu Asp Gly Ile Lys Asp His Leu Leu Cys 
            500                 505                 510         


Leu Arg Asp Val Leu Val Glu Arg Thr Lys Leu Gln Leu Ser Gln Lys 
        515                 520                 525             


Leu Gly Lys Gly Glu Phe Gly Ala Val Tyr Glu Gly Ile Phe Ser Pro 
    530                 535                 540                 


Lys Ile Gly Gln Asp Ile Arg Val Ala Val Lys Thr Ser Lys Asp Val 
545                 550                 555                 560 


Ile His Ser Glu Glu Asp Leu Glu Ser Phe Leu Lys Glu Ala Glu Met 
                565                 570                 575     


Met Lys His Phe Asp His Val Asn Val Val Lys Leu Leu Gly Phe Ser 
            580                 585                 590         


Pro Asn Pro Thr Ala Pro Ala Tyr Ala Gln His Leu Leu Ser Arg Cys 
        595                 600                 605             


Pro Thr Arg Ser Val Phe Tyr Pro Pro Cys Leu Phe Leu Val Met Gly 
    610                 615                 620                 


Val Ala Leu Glu Trp Asp Pro Glu Ser Ser Met Val Val Pro Leu Val 
625                 630                 635                 640 


Ile Leu Pro Tyr Met Lys His Arg Asp Leu His Ser Phe Leu Arg Ala 
                645                 650                 655     


Thr Arg Tyr Asp Asp Val Pro Met Phe Val Pro His Gln Ser Leu Leu 
            660                 665                 670         


Arg Phe Met Met Asp Ile Ala Ala Gly Met Glu Tyr Leu Ser Leu Gln 
        675                 680                 685             


Gly Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Gly Asp 
    690                 695                 700                 


Asp Leu Arg Val Cys Val Ala Asp Phe Gly Leu Ser Lys Met Met Tyr 
705                 710                 715                 720 


Ser Ser Asn Tyr Tyr Arg His Lys Ser Gln Asp Val Lys Leu Pro Val 
                725                 730                 735     


Arg Trp Met Ala Ile Glu Ser Val Ser Asp Phe Ile Phe Thr Thr Lys 
            740                 745                 750         


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Thr Ser Arg 
        755                 760                 765             


Gly Lys Val Pro Tyr Pro Gly Val Ser Asn Tyr Glu Leu Leu Asp Tyr 
    770                 775                 780                 


Leu Glu Lys Gly His Arg Leu Ser Gln Gly Asp Asn Asp Ser Lys Leu 
785                 790                 795                 800 


Tyr Glu Leu Met Leu Ser Cys Trp His Arg Asp Pro Ser Gln Arg Pro 
                805                 810                 815     


Ser Phe Gly Glu Leu His Gln Ser Phe Ser Ala Leu Leu Ser Glu Leu 
            820                 825                 830         


Pro Leu Leu Glu Asp Arg Met Glu Ser His Tyr Ile Asn Leu Gly Leu 
        835                 840                 845             


Glu Ala Ala Asn Asp Arg Gln Asp Ser Ala Gln Asn Gln Val Glu Asn 
    850                 855                 860                 


Lys Thr Asp Tyr Leu Asp Leu Leu Lys Thr Gly Glu Gly Phe Glu Glu 
865                 870                 875                 880 


Arg Glu Gly Lys Tyr Lys Glu Gly Glu Gln Lys Tyr Met 
                885                 890             


<210>  17
<211>  679
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic

<400>  17

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Ala Ala Glu 
        435                 440                 445             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    450                 455                 460                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
465                 470                 475                 480 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                485                 490                 495     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            500                 505                 510         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        515                 520                 525             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    530                 535                 540                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
545                 550                 555                 560 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                565                 570                 575     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            580                 585                 590         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        595                 600                 605             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    610                 615                 620                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
625                 630                 635                 640 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                645                 650                 655     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            660                 665                 670         


Leu Ser Leu Ser Pro Gly Lys 
        675                 


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X = Isoleucine or Leucine

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X = Isoleucine or Leucine

<400>  18

Lys Trp Xaa Ala Xaa Glu Ser 
1               5           


