                         SEQUENCE LISTING

<110>  California Institute of Technology
       Fasan, Rudi
        
<120>  ALKANE OXIDATION BY MODIFIED HYDROXYLASES

<130>  1034345-000261

<140>  Not yet known
<141>  2008-02-08

<150>  US 11/697,404
<151>  2007-04-06

<150>  60/900,243
<151>  2007-02-08

<160>  125   

<170>  PatentIn version 3.4

<210>  1
<211>  1048
<212>  PRT
<213>  Bacillus megaterium

<400>  1

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg Asp 
65                  70                  75                  80  


Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Glu 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  2
<211>  1060
<212>  PRT
<213>  Bacillus subtilis

<400>  2

Lys Glu Thr Ser Pro Ile Pro Gln Pro Lys Thr Phe Gly Pro Leu Gly 
1               5                   10                  15      


Asn Leu Pro Leu Ile Asp Lys Asp Lys Pro Thr Leu Ser Leu Ile Lys 
            20                  25                  30          


Leu Ala Glu Glu Gln Gly Pro Ile Phe Gln Ile His Thr Pro Ala Gly 
        35                  40                  45              


Thr Thr Ile Val Val Ser Gly His Glu Leu Val Lys Glu Val Cys Asp 
    50                  55                  60                  


Glu Glu Arg Phe Asp Lys Ser Ile Glu Gly Ala Leu Glu Lys Val Arg 
65                  70                  75                  80  


Ala Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Pro Asn 
                85                  90                  95      


Trp Arg Lys Ala His Asn Ile Leu Met Pro Thr Phe Ser Gln Arg Ala 
            100                 105                 110         


Met Lys Asp Tyr His Glu Lys Met Val Asp Ile Ala Val Gln Leu Ile 
        115                 120                 125             


Gln Lys Trp Ala Arg Leu Asn Pro Asn Glu Ala Val Asp Val Pro Gly 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Tyr Tyr Arg Glu Thr Pro His Pro Phe Ile Asn 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met His Gln Met Gln Arg Leu 
            180                 185                 190         


Asp Val Gln Asp Lys Leu Met Val Arg Thr Lys Arg Gln Phe Arg Tyr 
        195                 200                 205             


Asp Ile Gln Thr Met Phe Ser Leu Val Asp Ser Ile Ile Ala Glu Arg 
    210                 215                 220                 


Arg Ala Asn Gly Asp Gln Asp Glu Lys Asp Leu Leu Ala Arg Met Leu 
225                 230                 235                 240 


Asn Val Glu Asp Pro Glu Thr Gly Glu Lys Leu Asp Asp Glu Asn Ile 
                245                 250                 255     


Arg Phe Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser 
            260                 265                 270         


Gly Leu Leu Ser Phe Ala Thr Tyr Phe Leu Leu Lys His Pro Asp Lys 
        275                 280                 285             


Leu Lys Lys Ala Tyr Glu Glu Val Asp Arg Val Leu Thr Asp Ala Ala 
    290                 295                 300                 


Pro Thr Tyr Lys Gln Val Leu Glu Leu Thr Tyr Ile Arg Met Ile Leu 
305                 310                 315                 320 


Asn Glu Ser Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr 
                325                 330                 335     


Pro Lys Glu Asp Thr Val Ile Gly Gly Lys Phe Pro Ile Thr Thr Asn 
            340                 345                 350         


Asp Arg Ile Ser Val Leu Ile Pro Gln Leu His Arg Asp Arg Asp Ala 
        355                 360                 365             


Trp Gly Lys Asp Ala Glu Glu Phe Arg Pro Glu Arg Phe Glu His Gln 
    370                 375                 380                 


Asp Gln Val Pro His His Ala Tyr Lys Pro Phe Gly Asn Gly Gln Arg 
385                 390                 395                 400 


Ala Cys Ile Gly Met Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu 
                405                 410                 415     


Gly Met Ile Leu Lys Tyr Phe Thr Leu Ile Asp His Glu Asn Tyr Glu 
            420                 425                 430         


Leu Asp Ile Lys Gln Thr Leu Thr Leu Lys Pro Gly Asp Phe His Ile 
        435                 440                 445             


Ser Val Gln Ser Arg His Gln Glu Ala Ile His Ala Asp Val Gln Ala 
    450                 455                 460                 


Ala Glu Lys Ala Ala Pro Asp Glu Gln Lys Glu Lys Thr Glu Ala Lys 
465                 470                 475                 480 


Gly Ala Ser Val Ile Gly Leu Asn Asn Arg Pro Leu Leu Val Leu Tyr 
                485                 490                 495     


Gly Ser Asp Thr Gly Thr Ala Glu Gly Val Ala Arg Glu Leu Ala Asp 
            500                 505                 510         


Thr Ala Ser Leu His Gly Val Arg Thr Lys Thr Ala Pro Leu Asn Asp 
        515                 520                 525             


Arg Ile Gly Lys Leu Pro Lys Glu Gly Ala Val Val Ile Val Thr Ser 
    530                 535                 540                 


Ser Tyr Asn Gly Lys Pro Pro Ser Asn Ala Gly Gln Phe Val Gln Trp 
545                 550                 555                 560 


Leu Gln Glu Ile Lys Pro Gly Glu Leu Glu Gly Val His Tyr Ala Val 
                565                 570                 575     


Phe Gly Cys Gly Asp His Asn Trp Ala Ser Thr Tyr Gln Tyr Val Pro 
            580                 585                 590         


Arg Phe Ile Asp Glu Gln Leu Ala Glu Lys Gly Ala Thr Arg Phe Ser 
        595                 600                 605             


Ala Arg Gly Glu Gly Asp Val Ser Gly Asp Phe Glu Gly Gln Leu Asp 
    610                 615                 620                 


Glu Trp Lys Lys Ser Met Trp Ala Asp Ala Ile Lys Ala Phe Gly Leu 
625                 630                 635                 640 


Glu Leu Asn Glu Asn Ala Asp Lys Glu Arg Ser Thr Leu Ser Leu Gln 
                645                 650                 655     


Phe Val Arg Gly Leu Gly Glu Ser Pro Leu Ala Arg Ser Tyr Glu Ala 
            660                 665                 670         


Ser His Ala Ser Ile Ala Glu Asn Arg Glu Leu Gln Ser Ala Asp Ser 
        675                 680                 685             


Asp Arg Ser Thr Arg His Ile Glu Ile Ala Leu Pro Pro Asp Val Glu 
    690                 695                 700                 


Tyr Gln Glu Gly Asp His Leu Gly Val Leu Pro Lys Asn Ser Gln Thr 
705                 710                 715                 720 


Asn Val Ser Arg Ile Leu His Arg Phe Gly Leu Lys Gly Thr Asp Gln 
                725                 730                 735     


Val Thr Leu Ser Ala Ser Gly Arg Ser Ala Gly His Leu Pro Leu Gly 
            740                 745                 750         


Arg Pro Val Ser Leu His Asp Leu Leu Ser Tyr Ser Val Glu Val Gln 
        755                 760                 765             


Glu Ala Ala Thr Arg Ala Gln Ile Arg Glu Leu Ala Ser Phe Thr Val 
    770                 775                 780                 


Cys Pro Pro His Arg Arg Glu Leu Glu Glu Leu Ser Ala Glu Gly Val 
785                 790                 795                 800 


Tyr Gln Glu Gln Ile Leu Lys Lys Arg Ile Ser Met Leu Asp Leu Leu 
                805                 810                 815     


Glu Lys Tyr Glu Ala Cys Asp Met Pro Phe Glu Arg Phe Leu Glu Leu 
            820                 825                 830         


Leu Arg Pro Leu Lys Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg 
        835                 840                 845             


Val Asn Pro Arg Gln Ala Ser Ile Thr Val Gly Val Val Arg Gly Pro 
    850                 855                 860                 


Ala Trp Ser Gly Arg Gly Glu Tyr Arg Gly Val Ala Ser Asn Asp Leu 
865                 870                 875                 880 


Ala Glu Arg Gln Ala Gly Asp Asp Val Val Met Phe Ile Arg Thr Pro 
                885                 890                 895     


Glu Ser Arg Phe Gln Leu Pro Lys Asp Pro Glu Thr Pro Ile Ile Met 
            900                 905                 910         


Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly Phe Leu Gln Ala 
        915                 920                 925             


Arg Asp Val Leu Lys Arg Glu Gly Lys Thr Leu Gly Glu Ala His Leu 
    930                 935                 940                 


Tyr Phe Gly Cys Arg Asn Asp Arg Asp Phe Ile Tyr Arg Asp Glu Leu 
945                 950                 955                 960 


Glu Arg Phe Glu Lys Asp Gly Ile Val Thr Val His Thr Ala Phe Ser 
                965                 970                 975     


Arg Lys Glu Gly Met Pro Lys Thr Tyr Val Gln His Leu Met Ala Asp 
            980                 985                 990         


Gln Ala Asp Thr Leu Ile Ser Ile  Leu Asp Arg Gly Gly  Arg Leu Tyr 
        995                 1000                 1005             


Val Cys  Gly Asp Gly Ser Lys  Met Ala Pro Asp Val  Glu Ala Ala 
    1010                 1015                 1020             


Leu Gln  Lys Ala Tyr Gln Ala  Val His Gly Thr Gly  Glu Gln Glu 
    1025                 1030                 1035             


Ala Gln  Asn Trp Leu Arg His  Leu Gln Asp Thr Gly  Met Tyr Ala 
    1040                 1045                 1050             


Lys Asp  Val Trp Ala Gly Ile  
    1055                 1060 


<210>  3
<211>  1053
<212>  PRT
<213>  Bacillus subtilis

<400>  3

Lys Gln Ala Ser Ala Ile Pro Gln Pro Lys Thr Tyr Gly Pro Leu Lys 
1               5                   10                  15      


Asn Leu Pro His Leu Glu Lys Glu Gln Leu Ser Gln Ser Leu Trp Arg 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Pro Ile Phe Arg Phe Asp Phe Pro Gly Val 
        35                  40                  45              


Ser Ser Val Phe Val Ser Gly His Asn Leu Val Ala Glu Val Cys Asp 
    50                  55                  60                  


Glu Lys Arg Phe Asp Lys Asn Leu Gly Lys Gly Leu Gln Lys Val Arg 
65                  70                  75                  80  


Glu Phe Gly Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Pro Asn 
                85                  90                  95      


Trp Gln Lys Ala His Arg Ile Leu Leu Pro Ser Phe Ser Gln Lys Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ser Met Met Leu Asp Ile Ala Thr Gln Leu Ile 
        115                 120                 125             


Gln Lys Trp Ser Arg Leu Asn Pro Asn Glu Glu Ile Asp Val Ala Asp 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Ser Gln His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Leu Arg Ala Leu Lys Glu Ala Met Asn Gln Ser Lys Arg Leu 
            180                 185                 190         


Gly Leu Gln Asp Lys Met Met Val Lys Thr Lys Leu Gln Phe Gln Lys 
        195                 200                 205             


Asp Ile Glu Val Met Asn Ser Leu Val Asp Arg Met Ile Ala Glu Arg 
    210                 215                 220                 


Lys Ala Asn Pro Asp Glu Asn Ile Lys Asp Leu Leu Ser Leu Met Leu 
225                 230                 235                 240 


Tyr Ala Lys Asp Pro Val Thr Gly Glu Thr Leu Asp Asp Glu Asn Ile 
                245                 250                 255     


Arg Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser 
            260                 265                 270         


Gly Leu Leu Ser Phe Ala Ile Tyr Cys Leu Leu Thr His Pro Glu Lys 
        275                 280                 285             


Leu Lys Lys Ala Gln Glu Glu Ala Asp Arg Val Leu Thr Asp Asp Thr 
    290                 295                 300                 


Pro Glu Tyr Lys Gln Ile Gln Gln Leu Lys Tyr Ile Arg Met Val Leu 
305                 310                 315                 320 


Asn Glu Thr Leu Arg Leu Tyr Pro Thr Ala Pro Ala Phe Ser Leu Tyr 
                325                 330                 335     


Ala Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Ile Ser Lys Gly 
            340                 345                 350         


Gln Pro Val Thr Val Leu Ile Pro Lys Leu His Arg Asp Gln Asn Ala 
        355                 360                 365             


Trp Gly Pro Asp Ala Glu Asp Phe Arg Pro Glu Arg Phe Glu Asp Pro 
    370                 375                 380                 


Ser Ser Ile Pro His His Ala Tyr Lys Pro Phe Gly Asn Gly Gln Arg 
385                 390                 395                 400 


Ala Cys Ile Gly Met Gln Phe Ala Leu Gln Glu Ala Thr Met Val Leu 
                405                 410                 415     


Gly Leu Val Leu Lys His Phe Glu Leu Ile Asn His Thr Gly Tyr Glu 
            420                 425                 430         


Leu Lys Ile Lys Glu Ala Leu Thr Ile Lys Pro Asp Asp Phe Lys Ile 
        435                 440                 445             


Thr Val Lys Pro Arg Lys Thr Ala Ala Ile Asn Val Gln Arg Lys Glu 
    450                 455                 460                 


Gln Ala Asp Ile Lys Ala Glu Thr Lys Pro Lys Glu Thr Lys Pro Lys 
465                 470                 475                 480 


His Gly Thr Pro Leu Leu Val Leu Phe Gly Ser Asn Leu Gly Thr Ala 
                485                 490                 495     


Glu Gly Ile Ala Gly Glu Leu Ala Ala Gln Gly Arg Gln Met Gly Phe 
            500                 505                 510         


Thr Ala Glu Thr Ala Pro Leu Asp Asp Tyr Ile Gly Lys Leu Pro Glu 
        515                 520                 525             


Glu Gly Ala Val Val Ile Val Thr Ala Ser Tyr Asn Gly Ala Pro Pro 
    530                 535                 540                 


Asp Asn Ala Ala Gly Phe Val Glu Trp Leu Lys Glu Leu Glu Glu Gly 
545                 550                 555                 560 


Gln Leu Lys Gly Val Ser Tyr Ala Val Phe Gly Cys Gly Asn Arg Ser 
                565                 570                 575     


Trp Ala Ser Thr Tyr Gln Arg Ile Pro Arg Leu Ile Asp Asp Met Met 
            580                 585                 590         


Lys Ala Lys Gly Ala Ser Arg Leu Thr Ala Ile Gly Glu Gly Asp Ala 
        595                 600                 605             


Ala Asp Asp Phe Glu Ser His Arg Glu Ser Trp Glu Asn Arg Phe Trp 
    610                 615                 620                 


Lys Glu Thr Met Asp Ala Phe Asp Ile Asn Glu Ile Ala Gln Lys Glu 
625                 630                 635                 640 


Asp Arg Pro Ser Leu Ser Ile Thr Phe Leu Ser Glu Ala Thr Glu Thr 
                645                 650                 655     


Pro Val Ala Lys Ala Tyr Gly Ala Phe Glu Gly Ile Val Leu Glu Asn 
            660                 665                 670         


Arg Glu Leu Gln Thr Ala Ala Ser Thr Arg Ser Thr Arg His Ile Glu 
        675                 680                 685             


Leu Glu Ile Pro Ala Gly Lys Thr Tyr Lys Glu Gly Asp His Ile Gly 
    690                 695                 700                 


Ile Leu Pro Lys Asn Ser Arg Glu Leu Val Gln Arg Val Leu Ser Arg 
705                 710                 715                 720 


Phe Gly Leu Gln Ser Asn His Val Ile Lys Val Ser Gly Ser Ala His 
                725                 730                 735     


Met Ala His Leu Pro Met Asp Arg Pro Ile Lys Val Val Asp Leu Leu 
            740                 745                 750         


Ser Ser Tyr Val Glu Leu Gln Glu Pro Ala Ser Arg Leu Gln Leu Arg 
        755                 760                 765             


Glu Leu Ala Ser Tyr Thr Val Cys Pro Pro His Gln Lys Glu Leu Glu 
    770                 775                 780                 


Gln Leu Val Ser Asp Asp Gly Ile Tyr Lys Glu Gln Val Leu Ala Lys 
785                 790                 795                 800 


Arg Leu Thr Met Leu Asp Phe Leu Glu Asp Tyr Pro Ala Cys Glu Met 
                805                 810                 815     


Pro Phe Glu Arg Phe Leu Ala Leu Leu Pro Ser Leu Lys Pro Arg Tyr 
            820                 825                 830         


Tyr Ser Ile Ser Ser Ser Pro Lys Val His Ala Asn Ile Val Ser Met 
        835                 840                 845             


Thr Val Gly Val Val Lys Ala Ser Ala Trp Ser Gly Arg Gly Glu Tyr 
    850                 855                 860                 


Arg Gly Val Ala Ser Asn Tyr Leu Ala Glu Leu Asn Thr Gly Asp Ala 
865                 870                 875                 880 


Ala Ala Cys Phe Ile Arg Thr Pro Gln Ser Gly Phe Gln Met Pro Asn 
                885                 890                 895     


Asp Pro Glu Thr Pro Met Ile Met Val Gly Pro Gly Thr Gly Ile Ala 
            900                 905                 910         


Pro Phe Arg Gly Phe Ile Gln Ala Arg Ser Val Leu Lys Lys Glu Gly 
        915                 920                 925             


Ser Thr Leu Gly Glu Ala Leu Leu Tyr Phe Gly Cys Arg Arg Pro Asp 
    930                 935                 940                 


His Asp Asp Leu Tyr Arg Glu Glu Leu Asp Gln Ala Glu Gln Asp Gly 
945                 950                 955                 960 


Leu Val Thr Ile Arg Arg Cys Tyr Ser Arg Val Glu Asn Glu Pro Lys 
                965                 970                 975     


Gly Tyr Val Gln His Leu Leu Lys Gln Asp Thr Gln Lys Leu Met Thr 
            980                 985                 990         


Leu Ile Glu Lys Gly Ala His Ile  Tyr Val Cys Gly Asp  Gly Ser Gln 
        995                 1000                 1005             


Met Ala  Pro Asp Val Glu Arg  Thr Leu Arg Leu Ala  Tyr Glu Ala 
    1010                 1015                 1020             


Glu Lys  Ala Ala Ser Gln Glu  Glu Ser Ala Val Trp  Leu Gln Lys 
    1025                 1030                 1035             


Leu Gln  Asp Gln Arg Arg Tyr  Val Lys Asp Val Trp  Thr Gly Met 
    1040                 1045                 1050             


<210>  4
<211>  1065
<212>  PRT
<213>  Bacillus cereus

<400>  4

Met Asp Lys Lys Val Ser Ala Ile Pro Gln Pro Lys Thr Tyr Gly Pro 
1               5                   10                  15      


Leu Gly Asn Leu Pro Leu Ile Asp Lys Asp Lys Pro Thr Leu Ser Phe 
            20                  25                  30          


Ile Lys Ile Ala Glu Glu Tyr Gly Pro Ile Phe Gln Ile Gln Thr Leu 
        35                  40                  45              


Ser Asp Thr Ile Ile Val Ile Ser Gly His Glu Leu Val Ala Glu Val 
    50                  55                  60                  


Cys Asp Glu Thr Arg Phe Asp Lys Ser Ile Glu Gly Ala Leu Ala Lys 
65                  70                  75                  80  


Val Arg Ala Phe Ala Gly Asp Gly Leu Phe Thr Ser Glu Thr Gln Glu 
                85                  90                  95      


Pro Asn Trp Lys Lys Ala His Asn Ile Leu Met Pro Thr Phe Ser Gln 
            100                 105                 110         


Arg Ala Met Lys Asp Tyr His Ala Met Met Val Asp Ile Ala Val Gln 
        115                 120                 125             


Leu Val Gln Lys Trp Ala Arg Leu Asn Pro Asn Glu Asn Val Asp Val 
    130                 135                 140                 


Pro Glu Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly 
145                 150                 155                 160 


Phe Asn Tyr Arg Phe Asn Ser Phe Tyr Arg Glu Thr Pro His Pro Phe 
                165                 170                 175     


Ile Thr Ser Met Thr Arg Ala Leu Asp Glu Ala Met His Gln Leu Gln 
            180                 185                 190         


Arg Leu Asp Ile Glu Asp Lys Leu Met Trp Arg Thr Lys Arg Gln Phe 
        195                 200                 205             


Gln His Asp Ile Gln Ser Met Phe Ser Leu Val Asp Asn Ile Ile Ala 
    210                 215                 220                 


Glu Arg Lys Ser Ser Gly Asn Gln Glu Glu Asn Asp Leu Leu Ser Arg 
225                 230                 235                 240 


Met Leu His Val Gln Asp Pro Glu Thr Gly Glu Lys Leu Asp Asp Glu 
                245                 250                 255     


Asn Ile Arg Phe Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr 
            260                 265                 270         


Thr Ser Gly Leu Leu Ser Phe Ala Ile Tyr Phe Leu Leu Lys Asn Pro 
        275                 280                 285             


Asp Lys Leu Lys Lys Ala Tyr Glu Glu Val Asp Arg Val Leu Thr Asp 
    290                 295                 300                 


Pro Thr Pro Thr Tyr Gln Gln Val Met Lys Leu Lys Tyr Ile Arg Met 
305                 310                 315                 320 


Ile Leu Asn Glu Ser Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser 
                325                 330                 335     


Leu Tyr Ala Lys Glu Asp Thr Val Ile Gly Gly Lys Tyr Pro Ile Lys 
            340                 345                 350         


Lys Gly Glu Asp Arg Ile Ser Val Leu Ile Pro Gln Leu His Arg Asp 
        355                 360                 365             


Lys Asp Ala Trp Gly Asp Asn Val Glu Glu Phe Gln Pro Glu Arg Phe 
    370                 375                 380                 


Glu Asp Leu Asp Lys Val Pro His His Ala Tyr Lys Pro Phe Gly Asn 
385                 390                 395                 400 


Gly Gln Arg Ala Cys Ile Gly Met Gln Phe Ala Leu His Glu Ala Thr 
                405                 410                 415     


Leu Val Met Gly Met Leu Leu Gln His Phe Glu Phe Ile Asp Tyr Glu 
            420                 425                 430         


Asp Tyr Gln Leu Asp Val Lys Gln Thr Leu Thr Leu Lys Pro Gly Asp 
        435                 440                 445             


Phe Lys Ile Arg Ile Val Pro Arg Asn Gln Asn Ile Ser His Thr Thr 
    450                 455                 460                 


Val Leu Ala Pro Thr Glu Glu Lys Leu Lys Asn His Glu Ile Lys Gln 
465                 470                 475                 480 


Gln Val Gln Lys Thr Pro Ser Ile Ile Gly Ala Asp Asn Leu Ser Leu 
                485                 490                 495     


Leu Val Leu Tyr Gly Ser Asp Thr Gly Val Ala Glu Gly Ile Ala Arg 
            500                 505                 510         


Glu Leu Ala Asp Thr Ala Ser Leu Glu Gly Val Gln Thr Glu Val Ala 
        515                 520                 525             


Ala Leu Asn Asp Arg Ile Gly Ser Leu Pro Lys Glu Gly Ala Val Leu 
    530                 535                 540                 


Ile Val Thr Ser Ser Tyr Asn Gly Lys Pro Pro Ser Asn Ala Gly Gln 
545                 550                 555                 560 


Phe Val Gln Trp Leu Glu Glu Leu Lys Pro Asp Glu Leu Lys Gly Val 
                565                 570                 575     


Gln Tyr Ala Val Phe Gly Cys Gly Asp His Asn Trp Ala Ser Thr Tyr 
            580                 585                 590         


Gln Arg Ile Pro Arg Tyr Ile Asp Glu Gln Met Ala Gln Lys Gly Ala 
        595                 600                 605             


Thr Arg Phe Ser Thr Arg Gly Glu Ala Asp Ala Ser Gly Asp Phe Glu 
    610                 615                 620                 


Glu Gln Leu Glu Gln Trp Lys Glu Ser Met Trp Ser Asp Ala Met Lys 
625                 630                 635                 640 


Ala Phe Gly Leu Glu Leu Asn Lys Asn Met Glu Lys Glu Arg Ser Thr 
                645                 650                 655     


Leu Ser Leu Gln Phe Val Ser Arg Leu Gly Gly Ser Pro Leu Ala Arg 
            660                 665                 670         


Thr Tyr Glu Ala Val Tyr Ala Ser Ile Leu Glu Asn Arg Glu Leu Gln 
        675                 680                 685             


Ser Ser Ser Ser Glu Arg Ser Thr Arg His Ile Glu Ile Ser Leu Pro 
    690                 695                 700                 


Glu Gly Ala Thr Tyr Lys Glu Gly Asp His Leu Gly Val Leu Pro Ile 
705                 710                 715                 720 


Asn Ser Glu Lys Asn Val Asn Arg Ile Leu Lys Arg Phe Gly Leu Asn 
                725                 730                 735     


Gly Lys Asp Gln Val Ile Leu Ser Ala Ser Gly Arg Ser Val Asn His 
            740                 745                 750         


Ile Pro Leu Asp Ser Pro Val Arg Leu Tyr Asp Leu Leu Ser Tyr Ser 
        755                 760                 765             


Val Glu Val Gln Glu Ala Ala Thr Arg Ala Gln Ile Arg Glu Met Val 
    770                 775                 780                 


Thr Phe Thr Ala Cys Pro Pro His Lys Lys Glu Leu Glu Ser Leu Leu 
785                 790                 795                 800 


Glu Asp Gly Val Tyr His Glu Gln Ile Leu Lys Lys Arg Ile Ser Met 
                805                 810                 815     


Leu Asp Leu Leu Glu Lys Tyr Glu Ala Cys Glu Ile Arg Phe Glu Arg 
            820                 825                 830         


Phe Leu Glu Leu Leu Pro Ala Leu Lys Pro Arg Tyr Tyr Ser Ile Ser 
        835                 840                 845             


Ser Ser Pro Leu Ile Ala Gln Asp Arg Leu Ser Ile Thr Val Gly Val 
    850                 855                 860                 


Val Asn Ala Pro Ala Trp Ser Gly Glu Gly Thr Tyr Glu Gly Val Ala 
865                 870                 875                 880 


Ser Asn Tyr Leu Ala Gln Arg His Asn Lys Asp Glu Ile Ile Cys Phe 
                885                 890                 895     


Ile Arg Thr Pro Gln Ser Asn Phe Gln Leu Pro Glu Asn Pro Glu Thr 
            900                 905                 910         


Pro Ile Ile Met Val Gly Pro Gly Thr Gly Ile Ala Pro Phe Arg Gly 
        915                 920                 925             


Phe Leu Gln Ala Arg Arg Val Gln Lys Gln Lys Gly Met Asn Leu Gly 
    930                 935                 940                 


Glu Ala His Leu Tyr Phe Gly Cys Arg His Pro Glu Lys Asp Tyr Leu 
945                 950                 955                 960 


Tyr Arg Thr Glu Leu Glu Asn Asp Glu Arg Asp Gly Leu Ile Ser Leu 
                965                 970                 975     


His Thr Ala Phe Ser Arg Leu Glu Gly His Pro Lys Thr Tyr Val Gln 
            980                 985                 990         


His Val Ile Lys Glu Asp Arg Met  Asn Leu Ile Ser Leu  Leu Asp Asn 
        995                 1000                 1005             


Gly Ala  His Leu Tyr Ile Cys  Gly Asp Gly Ser Lys  Met Ala Pro 
    1010                 1015                 1020             


Asp Val  Glu Asp Thr Leu Cys  Gln Ala Tyr Gln Glu  Ile His Glu 
    1025                 1030                 1035             


Val Ser  Glu Gln Glu Ala Arg  Asn Trp Leu Asp Arg  Leu Gln Asp 
    1040                 1045                 1050             


Glu Gly  Arg Tyr Gly Lys Asp  Val Trp Ala Gly Ile  
    1055                 1060                 1065 


<210>  5
<211>  1063
<212>  PRT
<213>  Ralstonia sp.

<400>  5

Ser Thr Ala Thr Pro Ala Ala Ala Leu Glu Pro Ile Pro Arg Asp Pro 
1               5                   10                  15      


Gly Trp Pro Ile Phe Gly Asn Leu Phe Gln Ile Thr Pro Gly Glu Val 
            20                  25                  30          


Gly Gln His Leu Leu Ala Arg Ser Arg His His Asp Gly Ile Phe Glu 
        35                  40                  45              


Leu Asp Phe Ala Gly Lys Arg Val Pro Phe Val Ser Ser Val Ala Leu 
    50                  55                  60                  


Ala Ser Glu Leu Cys Asp Ala Thr Arg Phe Arg Lys Ile Ile Gly Pro 
65                  70                  75                  80  


Pro Leu Ser Tyr Leu Arg Asp Met Ala Gly Asp Gly Leu Phe Thr Ala 
                85                  90                  95      


His Ser Asp Glu Pro Asn Trp Gly Cys Ala His Arg Ile Leu Met Pro 
            100                 105                 110         


Ala Phe Ser Gln Arg Ala Met Lys Ala Tyr Phe Asp Val Met Leu Arg 
        115                 120                 125             


Val Ala Asn Arg Leu Val Asp Lys Trp Asp Arg Gln Gly Pro Asp Ala 
    130                 135                 140                 


Asp Ile Ala Val Ala Asp Asp Met Thr Arg Leu Thr Leu Asp Thr Ile 
145                 150                 155                 160 


Ala Leu Ala Gly Phe Gly Tyr Asp Phe Ala Ser Phe Ala Ser Asp Glu 
                165                 170                 175     


Leu Asp Pro Phe Val Met Ala Met Val Gly Ala Leu Gly Glu Ala Met 
            180                 185                 190         


Gln Lys Leu Thr Arg Leu Pro Ile Gln Asp Arg Phe Met Gly Arg Ala 
        195                 200                 205             


His Arg Gln Ala Ala Glu Asp Ile Ala Tyr Met Arg Asn Leu Val Asp 
    210                 215                 220                 


Asp Val Ile Arg Gln Arg Arg Val Ser Pro Thr Ser Gly Met Asp Leu 
225                 230                 235                 240 


Leu Asn Leu Met Leu Glu Ala Arg Asp Pro Glu Thr Asp Arg Arg Leu 
                245                 250                 255     


Asp Asp Ala Asn Ile Arg Asn Gln Val Ile Thr Phe Leu Ile Ala Gly 
            260                 265                 270         


His Glu Thr Thr Ser Gly Leu Leu Thr Phe Ala Leu Tyr Glu Leu Leu 
        275                 280                 285             


Arg Asn Pro Gly Val Leu Ala Gln Ala Tyr Ala Glu Val Asp Thr Val 
    290                 295                 300                 


Leu Pro Gly Asp Ala Leu Pro Val Tyr Ala Asp Leu Ala Arg Met Pro 
305                 310                 315                 320 


Val Leu Asp Arg Val Leu Lys Glu Thr Leu Arg Leu Trp Pro Thr Ala 
                325                 330                 335     


Pro Ala Phe Ala Val Ala Pro Phe Asp Asp Val Val Leu Gly Gly Arg 
            340                 345                 350         


Tyr Arg Leu Arg Lys Asp Arg Arg Ile Ser Val Val Leu Thr Ala Leu 
        355                 360                 365             


His Arg Asp Pro Lys Val Trp Ala Asn Pro Glu Arg Phe Asp Ile Asp 
    370                 375                 380                 


Arg Phe Leu Pro Glu Asn Glu Ala Lys Leu Pro Ala His Ala Tyr Met 
385                 390                 395                 400 


Pro Phe Gly Gln Gly Glu Arg Ala Cys Ile Gly Arg Gln Phe Ala Leu 
                405                 410                 415     


Thr Glu Ala Lys Leu Ala Leu Ala Leu Met Leu Arg Asn Phe Ala Phe 
            420                 425                 430         


Gln Asp Pro His Asp Tyr Gln Phe Arg Leu Lys Glu Thr Leu Thr Ile 
        435                 440                 445             


Lys Pro Asp Gln Phe Val Leu Arg Val Arg Arg Arg Arg Pro His Glu 
    450                 455                 460                 


Arg Phe Val Thr Arg Gln Ala Ser Gln Ala Val Ala Asp Ala Ala Gln 
465                 470                 475                 480 


Thr Asp Val Arg Gly His Gly Gln Ala Met Thr Val Leu Cys Ala Ser 
                485                 490                 495     


Ser Leu Gly Thr Ala Arg Glu Leu Ala Glu Gln Ile His Ala Gly Ala 
            500                 505                 510         


Ile Ala Ala Gly Phe Asp Ala Lys Leu Ala Asp Leu Asp Asp Ala Val 
        515                 520                 525             


Gly Val Leu Pro Thr Ser Gly Leu Val Val Val Val Ala Ala Thr Tyr 
    530                 535                 540                 


Asn Gly Arg Ala Pro Asp Ser Ala Arg Lys Phe Glu Ala Met Leu Asp 
545                 550                 555                 560 


Ala Asp Asp Ala Ser Gly Tyr Arg Ala Asn Gly Met Arg Leu Ala Leu 
                565                 570                 575     


Leu Gly Cys Gly Asn Ser Gln Trp Ala Thr Tyr Gln Ala Phe Pro Arg 
            580                 585                 590         


Arg Val Phe Asp Phe Phe Ile Thr Ala Gly Ala Val Pro Leu Leu Pro 
        595                 600                 605             


Arg Gly Glu Ala Asp Gly Asn Gly Asp Phe Asp Gln Ala Ala Glu Arg 
    610                 615                 620                 


Trp Leu Ala Gln Leu Trp Gln Ala Leu Gln Ala Asp Gly Ala Gly Thr 
625                 630                 635                 640 


Gly Gly Leu Gly Val Asp Val Gln Val Arg Ser Met Ala Ala Ile Arg 
                645                 650                 655     


Ala Glu Thr Leu Pro Ala Gly Thr Gln Ala Phe Thr Val Leu Ser Asn 
            660                 665                 670         


Asp Glu Leu Val Gly Asp Pro Ser Gly Leu Trp Asp Phe Ser Ile Glu 
        675                 680                 685             


Ala Pro Arg Thr Ser Thr Arg Asp Ile Arg Leu Gln Leu Pro Pro Gly 
    690                 695                 700                 


Ile Thr Tyr Arg Thr Gly Asp His Ile Ala Val Trp Pro Gln Asn Asp 
705                 710                 715                 720 


Ala Gln Leu Val Ser Glu Leu Cys Glu Arg Leu Asp Leu Asp Pro Asp 
                725                 730                 735     


Ala Gln Ala Thr Ile Ser Ala Pro His Gly Met Gly Arg Gly Leu Pro 
            740                 745                 750         


Ile Asp Gln Ala Leu Pro Val Arg Gln Leu Leu Thr His Phe Ile Glu 
        755                 760                 765             


Leu Gln Asp Val Val Ser Arg Gln Thr Leu Arg Ala Leu Ala Gln Ala 
    770                 775                 780                 


Thr Arg Cys Pro Phe Thr Lys Gln Ser Ile Glu Gln Leu Ala Ser Asp 
785                 790                 795                 800 


Asp Ala Glu His Gly Tyr Ala Thr Lys Val Val Ala Arg Arg Leu Gly 
                805                 810                 815     


Ile Leu Asp Val Leu Val Glu His Pro Ala Ile Ala Leu Thr Leu Gln 
            820                 825                 830         


Glu Leu Leu Ala Cys Thr Val Pro Met Arg Pro Arg Leu Tyr Ser Ile 
        835                 840                 845             


Ala Ser Ser Pro Leu Val Ser Pro Asp Val Ala Thr Leu Leu Val Gly 
    850                 855                 860                 


Thr Val Cys Ala Pro Ala Leu Ser Gly Arg Gly Gln Phe Arg Gly Val 
865                 870                 875                 880 


Ala Ser Thr Trp Leu Gln His Leu Pro Pro Gly Ala Arg Val Ser Ala 
                885                 890                 895     


Ser Ile Arg Thr Pro Asn Pro Pro Phe Ala Pro Asp Pro Asp Pro Ala 
            900                 905                 910         


Ala Pro Met Leu Leu Ile Gly Pro Gly Thr Gly Ile Ala Pro Phe Arg 
        915                 920                 925             


Gly Phe Leu Glu Glu Arg Ala Leu Arg Lys Met Ala Gly Asn Ala Val 
    930                 935                 940                 


Thr Pro Ala Gln Leu Tyr Phe Gly Cys Arg His Pro Gln His Asp Trp 
945                 950                 955                 960 


Leu Tyr Arg Glu Asp Ile Glu Arg Trp Ala Gly Gln Gly Val Val Glu 
                965                 970                 975     


Val His Pro Ala Tyr Ser Val Val Pro Asp Ala Pro Arg Tyr Val Gln 
            980                 985                 990         


Asp Leu Leu Trp Gln Arg Arg Glu  Gln Val Trp Ala Gln  Val Arg Asp 
        995                 1000                 1005             


Gly Ala  Thr Ile Tyr Val Cys  Gly Asp Gly Arg Arg  Met Ala Pro 
    1010                 1015                 1020             


Ala Val  Arg Gln Thr Leu Ile  Glu Ile Gly Met Ala  Gln Gly Gly 
    1025                 1030                 1035             


Met Thr  Asp Lys Ala Ala Ser  Asp Trp Phe Gly Gly  Leu Val Ala 
    1040                 1045                 1050             


Gln Gly  Arg Tyr Arg Gln Asp  Val Phe Asn 
    1055                 1060             


<210>  6
<211>  1077
<212>  PRT
<213>  Bradyrhizobium japonicum

<400>  6

Ser Ser Lys Asn Arg Leu Asp Pro Ile Pro Gln Pro Pro Thr Lys Pro 
1               5                   10                  15      


Val Val Gly Asn Met Leu Ser Leu Asp Ser Ala Ala Pro Val Gln His 
            20                  25                  30          


Leu Thr Arg Leu Ala Lys Glu Leu Gly Pro Ile Phe Trp Leu Asp Met 
        35                  40                  45              


Met Gly Ser Pro Ile Val Val Val Ser Gly His Asp Leu Val Asp Glu 
    50                  55                  60                  


Leu Ser Asp Glu Lys Arg Phe Asp Lys Thr Val Arg Gly Ala Leu Arg 
65                  70                  75                  80  


Arg Val Arg Ala Val Gly Gly Asp Gly Leu Phe Thr Ala Asp Thr Arg 
                85                  90                  95      


Glu Pro Asn Trp Ser Lys Ala His Asn Ile Leu Leu Gln Pro Phe Gly 
            100                 105                 110         


Asn Arg Ala Met Gln Ser Tyr His Pro Ser Met Val Asp Ile Ala Glu 
        115                 120                 125             


Gln Leu Val Gln Lys Trp Glu Arg Leu Asn Ala Asp Asp Glu Ile Asp 
    130                 135                 140                 


Val Val His Asp Met Thr Ala Leu Thr Leu Asp Thr Ile Gly Leu Cys 
145                 150                 155                 160 


Gly Phe Asp Tyr Arg Phe Asn Ser Phe Tyr Arg Arg Asp Tyr His Pro 
                165                 170                 175     


Phe Val Glu Ser Leu Val Arg Ser Leu Glu Thr Ile Met Met Thr Arg 
            180                 185                 190         


Gly Leu Pro Phe Glu Gln Ile Trp Met Gln Lys Arg Arg Lys Thr Leu 
        195                 200                 205             


Ala Glu Asp Val Ala Phe Met Asn Lys Met Val Asp Glu Ile Ile Ala 
    210                 215                 220                 


Glu Arg Arg Lys Ser Ala Glu Gly Ile Asp Asp Lys Lys Asp Met Leu 
225                 230                 235                 240 


Ala Ala Met Met Thr Gly Val Asp Arg Ser Thr Gly Glu Gln Leu Asp 
                245                 250                 255     


Asp Val Asn Ile Arg Tyr Gln Ile Asn Thr Phe Leu Ile Ala Gly His 
            260                 265                 270         


Glu Thr Thr Ser Gly Leu Leu Ser Tyr Thr Leu Tyr Ala Leu Leu Lys 
        275                 280                 285             


His Pro Asp Ile Leu Lys Lys Ala Tyr Asp Glu Val Asp Arg Val Phe 
    290                 295                 300                 


Gly Pro Asp Val Asn Ala Lys Pro Thr Tyr Gln Gln Val Thr Gln Leu 
305                 310                 315                 320 


Thr Tyr Ile Thr Gln Ile Leu Lys Glu Ala Leu Arg Leu Trp Pro Pro 
                325                 330                 335     


Ala Pro Ala Tyr Gly Ile Ser Pro Leu Ala Asp Glu Thr Ile Gly Gly 
            340                 345                 350         


Gly Lys Tyr Lys Leu Arg Lys Gly Thr Phe Ile Thr Ile Leu Val Thr 
        355                 360                 365             


Ala Leu His Arg Asp Pro Ser Val Trp Gly Pro Asn Pro Asp Ala Phe 
    370                 375                 380                 


Asp Pro Glu Asn Phe Ser Arg Glu Ala Glu Ala Lys Arg Pro Ile Asn 
385                 390                 395                 400 


Ala Trp Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys Ile Gly Arg Gly 
                405                 410                 415     


Phe Ala Met His Glu Ala Ala Leu Ala Leu Gly Met Ile Leu Gln Arg 
            420                 425                 430         


Phe Lys Leu Ile Asp His Gln Arg Tyr Gln Met His Leu Lys Glu Thr 
        435                 440                 445             


Leu Thr Met Lys Pro Glu Gly Phe Lys Ile Lys Val Arg Pro Arg Ala 
    450                 455                 460                 


Asp Arg Glu Arg Gly Ala Tyr Gly Gly Pro Val Ala Ala Val Ser Ser 
465                 470                 475                 480 


Ala Pro Arg Ala Pro Arg Gln Pro Thr Ala Arg Pro Gly His Asn Thr 
                485                 490                 495     


Pro Met Leu Val Leu Tyr Gly Ser Asn Leu Gly Thr Ala Glu Glu Leu 
            500                 505                 510         


Ala Thr Arg Met Ala Asp Leu Ala Glu Ile Asn Gly Phe Ala Val His 
        515                 520                 525             


Leu Gly Ala Leu Asp Glu Tyr Val Gly Lys Leu Pro Gln Glu Gly Gly 
    530                 535                 540                 


Val Leu Ile Ile Cys Ala Ser Tyr Asn Gly Ala Pro Pro Asp Asn Ala 
545                 550                 555                 560 


Thr Gln Phe Val Lys Trp Leu Gly Ser Asp Leu Pro Lys Asp Ala Phe 
                565                 570                 575     


Ala Asn Val Arg Tyr Ala Val Phe Gly Cys Gly Asn Ser Asp Trp Ala 
            580                 585                 590         


Ala Thr Tyr Gln Ser Val Pro Arg Phe Ile Asp Glu Gln Leu Ser Gly 
        595                 600                 605             


His Gly Ala Arg Ala Val Tyr Pro Arg Gly Glu Gly Asp Ala Arg Ser 
    610                 615                 620                 


Asp Leu Asp Gly Gln Phe Gln Lys Trp Phe Pro Ala Ala Ala Gln Val 
625                 630                 635                 640 


Ala Thr Lys Glu Phe Gly Ile Asp Trp Asn Phe Thr Arg Thr Ala Glu 
                645                 650                 655     


Asp Asp Pro Leu Tyr Ala Ile Glu Pro Val Ala Val Thr Ala Val Asn 
            660                 665                 670         


Thr Ile Val Ala Gln Gly Gly Ala Val Ala Met Lys Val Leu Val Asn 
        675                 680                 685             


Asp Glu Leu Gln Asn Lys Ser Gly Ser Asn Pro Ser Glu Arg Ser Thr 
    690                 695                 700                 


Arg His Ile Glu Val Gln Leu Pro Ser Asn Ile Thr Tyr Arg Val Gly 
705                 710                 715                 720 


Asp His Leu Ser Val Val Pro Arg Asn Asp Pro Thr Leu Val Asp Ser 
                725                 730                 735     


Val Ala Arg Arg Phe Gly Phe Leu Pro Ala Asp Gln Ile Arg Leu Gln 
            740                 745                 750         


Val Ala Glu Gly Arg Arg Ala Gln Leu Pro Val Gly Glu Ala Val Ser 
        755                 760                 765             


Val Gly Arg Leu Leu Ser Glu Phe Val Glu Leu Gln Gln Val Ala Thr 
    770                 775                 780                 


Arg Lys Gln Ile Gln Ile Met Ala Glu His Thr Arg Cys Pro Val Thr 
785                 790                 795                 800 


Lys Pro Lys Leu Leu Ala Phe Val Gly Glu Glu Ala Glu Pro Ala Glu 
                805                 810                 815     


Arg Tyr Arg Thr Glu Ile Leu Ala Met Arg Lys Ser Val Tyr Asp Leu 
            820                 825                 830         


Leu Leu Glu Tyr Pro Ala Cys Glu Leu Pro Phe His Val Tyr Leu Glu 
        835                 840                 845             


Met Leu Ser Leu Leu Ala Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro 
    850                 855                 860                 


Ser Val Asp Pro Ala Arg Cys Ser Ile Thr Val Gly Val Val Glu Gly 
865                 870                 875                 880 


Pro Ala Ala Ser Gly Arg Gly Val Tyr Lys Gly Ile Cys Ser Asn Tyr 
                885                 890                 895     


Leu Ala Asn Arg Arg Ala Ser Asp Ala Ile Tyr Ala Thr Val Arg Glu 
            900                 905                 910         


Thr Lys Ala Gly Phe Arg Leu Pro Asp Asp Ser Ser Val Pro Ile Ile 
        915                 920                 925             


Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu Gln 
    930                 935                 940                 


Glu Arg Ala Ala Arg Lys Ala Lys Gly Ala Ser Leu Gly Pro Ala Met 
945                 950                 955                 960 


Leu Phe Phe Gly Cys Arg His Pro Asp Gln Asp Phe Leu Tyr Ala Asp 
                965                 970                 975     


Glu Leu Lys Ala Leu Ala Ala Ser Gly Val Thr Glu Leu Phe Thr Ala 
            980                 985                 990         


Phe Ser Arg Ala Asp Gly Pro Lys  Thr Tyr Val Gln His  Val Leu Ala 
        995                 1000                 1005             


Ala Gln  Lys Asp Lys Val Trp  Pro Leu Ile Glu Gln  Gly Ala Ile 
    1010                 1015                 1020             


Ile Tyr  Val Cys Gly Asp Gly  Gly Gln Met Glu Pro  Asp Val Lys 
    1025                 1030                 1035             


Ala Ala  Leu Val Ala Ile Arg  His Glu Lys Ser Gly  Ser Asp Thr 
    1040                 1045                 1050             


Ala Thr  Ala Ala Arg Trp Ile  Glu Glu Met Gly Ala  Thr Asn Arg 
    1055                 1060                 1065             


Tyr Val  Leu Asp Val Trp Ala  Gly Gly 
    1070                 1075         


<210>  7
<211>  1048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  7

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Gly 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  8
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  8

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Arg 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  9
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  9

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Tyr 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  10
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  10

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Thr 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  11
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  11

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro Arg Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Gly 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  12
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  12

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Gly 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Arg Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Leu Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  13
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  13

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Ser Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Gly 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asn Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


<210>  14
<211>  862
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus sequence

<400>  14

Ile Ile Pro Gln Pro Lys Thr Phe Gly Leu Gly Asn Leu Pro Leu Leu 
1               5                   10                  15      


Asp Asp Lys Pro Gln Ser Leu Ile Lys Ile Ala Asp Glu Leu Gly Pro 
            20                  25                  30          


Ile Phe Ile Asp Pro Gly Thr Ile Phe Val Ser Gly His Leu Val Glu 
        35                  40                  45              


Val Cys Asp Glu Ser Arg Phe Asp Lys Ile Ala Leu Lys Val Arg Asp 
    50                  55                  60                  


Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Pro Asn Trp 
65                  70                  75                  80  


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Arg Ala Met 
                85                  90                  95      


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
            100                 105                 110         


Lys Trp Glu Arg Leu Asn Pro Asp Glu Ile Asp Val Glu Asp Met Thr 
        115                 120                 125             


Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr Arg Phe 
    130                 135                 140                 


Asn Ser Phe Tyr Arg Asp Pro His Pro Phe Ile Ser Met Val Arg Ala 
145                 150                 155                 160 


Leu Asp Glu Ala Met Asn Leu Gln Arg Leu Ile Asp Asp Lys Met Arg 
                165                 170                 175     


Lys Arg Gln Phe Gln Glu Asp Ile Met Asn Leu Val Asp Ile Ile Ala 
            180                 185                 190         


Glu Arg Lys Ala Gly Asp Gln Asp Leu Leu Ser Met Leu Gly Lys Asp 
        195                 200                 205             


Pro Glu Thr Gly Glu Leu Asp Asp Glu Asn Ile Arg Tyr Gln Ile Ile 
    210                 215                 220                 


Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu Leu Ser Phe 
225                 230                 235                 240 


Ala Leu Tyr Phe Leu Leu Lys Asn Pro Asp Val Leu Lys Lys Ala Tyr 
                245                 250                 255     


Glu Glu Val Asp Arg Val Leu Asp Pro Thr Tyr Lys Gln Val Gln Leu 
            260                 265                 270         


Lys Tyr Ile Met Val Leu Asn Glu Ala Leu Arg Leu Trp Pro Thr Ala 
        275                 280                 285             


Pro Ala Phe Ser Leu Tyr Ala Lys Glu Asp Thr Val Leu Gly Gly Tyr 
    290                 295                 300                 


Pro Ile Lys Gly Asp Ile Ser Val Leu Ile Pro Gln Leu His Arg Asp 
305                 310                 315                 320 


Lys Ile Trp Gly Asp Glu Glu Phe Arg Pro Glu Arg Phe Glu Ser Ile 
                325                 330                 335     


Pro His Ala Tyr Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys Ile Gly 
            340                 345                 350         


Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met Met Leu Lys 
        355                 360                 365             


His Phe Asp Phe Ile Asp His Tyr Glu Leu Asp Ile Lys Glu Thr Leu 
    370                 375                 380                 


Thr Leu Lys Pro Glu Phe Ile Lys Val Lys Arg Lys Ala Pro Gly Lys 
385                 390                 395                 400 


Ser Ala His Asn Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Leu Gly 
                405                 410                 415     


Thr Ala Glu Gly Ile Ala Arg Glu Leu Ala Asp Ala Gly Phe Val Ala 
            420                 425                 430         


Leu Asp Asp His Ile Gly Leu Pro Lys Glu Gly Ala Val Leu Ile Val 
        435                 440                 445             


Thr Ala Ser Tyr Asn Gly Pro Pro Asp Asn Ala Gln Phe Val Trp Leu 
    450                 455                 460                 


Asp Asp Glu Leu Lys Gly Val Arg Tyr Ala Val Phe Gly Cys Gly Asp 
465                 470                 475                 480 


Asn Trp Ala Ser Thr Tyr Gln Lys Val Pro Arg Phe Ile Asp Glu Leu 
                485                 490                 495     


Ala Ala Lys Gly Ala Ile Ala Arg Gly Glu Ala Asp Ala Ser Asp Phe 
            500                 505                 510         


Glu Gly Glu Trp Lys Met Trp Ser Asp Phe Gly Leu Asp Ile Asp Asp 
        515                 520                 525             


Arg Ser Thr Leu Ser Leu Gln Phe Val Ala Asp Ser Pro Leu Ala Lys 
    530                 535                 540                 


Tyr Gly Ala Val Leu Asn Arg Glu Leu Gln Ala Ser Arg Ser Thr Arg 
545                 550                 555                 560 


His Ile Glu Ile Leu Pro Thr Tyr Lys Glu Gly Asp His Leu Gly Val 
                565                 570                 575     


Leu Pro Arg Asn Leu Val Asn Arg Val Arg Phe Gly Leu Ala Gln Ile 
            580                 585                 590         


Arg Leu Ser Ala Leu Ala His Leu Pro Leu Ala Lys Val Ser Val Asp 
        595                 600                 605             


Leu Leu Ser Tyr Val Glu Leu Gln Asp Ala Thr Arg Gln Leu Arg Met 
    610                 615                 620                 


Ala Ala Thr Val Cys Pro Pro His Lys Glu Leu Glu Ala Leu Leu Asp 
625                 630                 635                 640 


Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Ser Met Leu Asp Leu Leu 
                645                 650                 655     


Glu Lys Tyr Pro Ala Cys Glu Met Phe Phe Leu Ala Leu Leu Pro Ser 
            660                 665                 670         


Leu Lys Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Val Ala Ser 
        675                 680                 685             


Ile Thr Val Gly Val Val Gly Pro Ala Trp Ser Gly Arg Gly Glu Tyr 
    690                 695                 700                 


Lys Gly Val Ala Ser Asn Tyr Leu Ala Glu Leu Gln Gly Asp Ile Cys 
705                 710                 715                 720 


Phe Ile Arg Thr Pro Gln Ser Phe Leu Pro Asp Pro Glu Thr Pro Ile 
                725                 730                 735     


Ile Met Val Gly Pro Gly Thr Gly Ile Ala Pro Phe Arg Gly Phe Leu 
            740                 745                 750         


Gln Ala Arg Val Leu Lys Gly Ser Leu Gly Glu Ala His Leu Tyr Phe 
        755                 760                 765             


Gly Cys Arg Pro Asp Asp Tyr Leu Tyr Arg Glu Glu Leu Glu Asn Asp 
    770                 775                 780                 


Gly Ile Ile Thr Leu His Thr Ala Phe Ser Arg Met Glu Pro Lys Thr 
785                 790                 795                 800 


Tyr Val Gln His Val Leu Gln Asp Lys Leu Ile Leu Leu Asp Gln Gly 
                805                 810                 815     


Ala His Ile Tyr Val Cys Gly Asp Gly Ser Gln Met Ala Pro Asp Val 
            820                 825                 830         


Glu Ala Thr Leu Met Ala Tyr Asp Val His Gly Val Ser Glu Glu Ala 
        835                 840                 845             


Trp Leu Leu Asp Gly Arg Tyr Ala Lys Asp Val Trp Ala Gly 
    850                 855                 860         


<210>  15
<211>  3147
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  15
atgacaatta aagaaatgcc tcagccaaaa acgtttggag agcttaaaaa tttaccgtta     60

ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc    120

tttaaattcg aggcgcctgg ttgtgtaacg cgctacttat caagtcagcg tctaattaaa    180

gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa attctttcgt    240

gattttagcg gagacgggtt atttacaagc tggacgcatg aaataaattg gaaaaaagcg    300

cataatatct tacttccaag ctttagtcag caggcaatga aaggctatca tgcgatgatg    360

gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt    420

gaagtatcgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac    480

tatcgcttta acagctttta ccgagatcag cctcatccat ttattataag tatggtccgt    540

gcactggatg aagtaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat    600

gaaaacaagc gccagtgtca agaagatatc aaggtgatga acgacctagt agataaaatt    660

attgcagatc gcaaagcaag gggtgaacaa agcgatgatt tattaacgca gatgctaaac    720

ggaaaagatc cagaaacggg tgagccgctt gatgacggga acattagcta tcaaattatt    780

acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc    840

ttagtgaaaa atccacatgt attacaaaaa gtagcagaag aagcagcacg agttctagta    900

gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac    960

gaagcgctgc gcttatggcc aacttttcct gcgttttccc tatatgcaaa agaagatacg   1020

gtgcttggag gagaatatcc tttagaaaaa ggcgacgaag taatggttct gattcctcag   1080

cttcaccgtg ataaaacaat ttggggagac gatgtggagg agttccgtcc agagcgtttt   1140

gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg   1200

tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa   1260

cactttgact ttgaagatca tacaaactac gagctcgata ttaaagaaac tttaacgtta   1320

aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct   1380

tcacctagca ctgaacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat   1440

acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat   1500

ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac   1560

gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat   1620

ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta   1680

aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa   1740

aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac   1800

cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat   1860

atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa   1920

tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac   1980

ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga   2040

agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat   2100

ttaggtgtta ttcctcgcaa ctatgaagga atagtaaacc gtgtaacagc aaggttcggc   2160

ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca   2220

ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt   2280

acgcgcacgc agcttcgcgc aatggctgct aaaacggtct gcccgccgca taaagtagag   2340

cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca   2400

atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc   2460

cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa   2520

aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa   2580

tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc   2640

tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc   2700

atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag   2760

ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct   2820

catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg   2880

cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg   2940

gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc   3000

ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac   3060

gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc   3120

cgatacgcaa aagacgtgtg ggctggg                                       3147


<210>  16
<211>  4500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  16
atgacaatta aagaaatgcc tcagccaaaa acgtttggag agcttaaaaa tttaccgtta     60

ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc    120

tttaaattcg aggcgcctgg ttgtgtaacg cgctacttat caagtcagcg tctaattaaa    180

gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa attctttcgt    240

gattttagcg gagacgggtt atttacaagc tggacgcatg aaataaattg gaaaaaagcg    300

cataatatct tacttccaag ctttagtcag caggcaatga aaggctatca tgcgatgatg    360

gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt    420

gaagtatcgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac    480

tatcgcttta acagctttta ccgagatcag cctcatccat ttattataag tatggtccgt    540

gcactggatg aagtaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat    600

gaaaacaagc gccagtgtca agaagatatc aaggtgatga acgacctagt agataaaatt    660

attgcagatc gcaaagcaag gggtgaacaa agcgatgatt tattaacgca gatgctaaac    720

ggaaaagatc cagaaacggg tgagccgctt gatgacggga acattagcta tcaaattatt    780

acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc    840

ttagtgaaaa atccacatgt attacaaaaa gtagcagaag aagcagcacg agttctagta    900

gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac    960

gaagcgctgc gcttatggcc aacttttcct gcgttttccc tatatgcaaa agaagatacg   1020

gtgcttggag gagaatatcc tttagaaaaa ggcgacgaag taatggttct gattcctcag   1080

cttcaccgtg ataaaacaat ttggggagac gatgtggagg agttccgtcc agagcgtttt   1140

gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg   1200

tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa   1260

cactttgact ttgaagatca tacaaactac gagctcgata ttaaagaaac tttaacgtta   1320

aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct   1380

tcacctagca ctgaacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat   1440

acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat   1500

ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac   1560

gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat   1620

ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta   1680

aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa   1740

aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac   1800

cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat   1860

atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa   1920

tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac   1980

ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga   2040

agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat   2100

ttaggtgtta ttcctcgcaa ctatgaagga atagtaaacc gtgtaacagc aaggttcggc   2160

ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca   2220

ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt   2280

acgcgcacgc agcttcgcgc aatggctgct aaaacggtct gcccgccgca taaagtagag   2340

cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca   2400

atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc   2460

cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa   2520

aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa   2580

tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc   2640

tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc   2700

atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag   2760

ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct   2820

catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg   2880

cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg   2940

gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc   3000

ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac   3060

gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc   3120

cgatacgcaa aagacgtgtg ggctgggtaa gaattcatcg atgataagct gtcaaacatg   3180

agcagatctg agcccgccta atgagcgggc ttttttttca gatctgcttg aagacgaaag   3240

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagcgt   3300

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta   3360

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc   3420

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt   3480

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg   3540

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca   3600

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcgggct   3660

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga   3720

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt tcaggtggca   3780

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata   3840

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga   3900

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc   3960

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg   4020

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc   4080

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat   4140

cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact   4200

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat   4260

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga   4320

tcggaggacc gaaggagcta accgcttttt tggttgagta ctcaccagtc acagaaaagc   4380

atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata   4440

acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt   4500


<210>  17
<211>  3147
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  17
atgacaatta aagaaatgcc tcagccaaaa acgtttggag agcttaaaaa tttaccgtta     60

ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc    120

tttaaattcg aggcgcctgg ttgtgtaacg cgctacttat caagtcagcg tctaattaaa    180

gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa attctttcgt    240

gattttagcg gagacgggtt atttacaagc tggacgcatg aaataaattg gaaaaaagcg    300

cataatatct tacttccaag ctttagtcag caggcaatga aaggctatca tgcgatgatg    360

gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt    420

gaagtatcgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac    480

tatcgcttta acagctttta ccgagatcag cctcatccat ttattataag tatggtccgt    540

gcactggatg aagtaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat    600

gaaaacaagc gccagtgtca agaagatatc aaggtgatga acgacctagt agataaaatt    660

attgcagatc gcaaagcaag gggtgaacaa agcgatgatt tattaacgca gatgctaaac    720

ggaaaagatc cagaaacggg tgagccgctt gatgacggga acattagcta tcaaattatt    780

acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc    840

ttagtgaaaa atccacatgt attacaaaaa gtagcagaag aagcagcacg agttctagta    900

gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac    960

gaagcgctgc gcttatggcc aacttttcct gcgttttccc tatatgcaaa agaagatacg   1020

gtgcttggag gagaatatcc tttagaaaaa ggcgacgaag taatggttct gattcctcag   1080

cttcaccgtg ataaaacaat ttggggagac gatgtggagg agttccgtcc agagcgtttt   1140

gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg   1200

tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa   1260

cactttgact ttgaagatca tacaaactac gagctcgata ttaaagaaac tttaacgtta   1320

aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct   1380

tcacctagca ctggacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat   1440

acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat   1500

ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac   1560

gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat   1620

ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta   1680

aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa   1740

aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac   1800

cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat   1860

atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa   1920

tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac   1980

ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga   2040

agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat   2100

ttaggtgtta ttcctcgcaa ctatgaagga acagtaaacc gtgtaacagc aaggttcggc   2160

ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca   2220

ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt   2280

acgcgcacgc agcttcgcgc aatggctgct aagacggtct gcccgccgca taaagtagag   2340

cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca   2400

atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc   2460

cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa   2520

aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa   2580

tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc   2640

tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc   2700

atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag   2760

ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct   2820

catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg   2880

cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg   2940

gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc   3000

ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac   3060

gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc   3120

cgatacgcaa aagacgtgtg ggctggg                                       3147


<210>  18
<211>  8060
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  18
atgacaatta aagaaatgcc tcagccaaaa acgtttggag agcttaaaaa tttaccgtta     60

ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc    120

tttaaattcg aggcgcctgg ttgtgtaacg cgctacttat caagtcagcg tctaattaaa    180

gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa attctttcgt    240

gattttagcg gagacgggtt atttacaagc tggacgcatg aaataaattg gaaaaaagcg    300

cataatatct tacttccaag ctttagtcag caggcaatga aaggctatca tgcgatgatg    360

gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt    420

gaagtatcgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac    480

tatcgcttta acagctttta ccgagatcag cctcatccat ttattataag tatggtccgt    540

gcactggatg aagtaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat    600

gaaaacaagc gccagtgtca agaagatatc aaggtgatga acgacctagt agataaaatt    660

attgcagatc gcaaagcaag gggtgaacaa agcgatgatt tattaacgca gatgctaaac    720

ggaaaagatc cagaaacggg tgagccgctt gatgacggga acattagcta tcaaattatt    780

acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc    840

ttagtgaaaa atccacatgt attacaaaaa gtagcagaag aagcagcacg agttctagta    900

gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac    960

gaagcgctgc gcttatggcc aacttttcct gcgttttccc tatatgcaaa agaagatacg   1020

gtgcttggag gagaatatcc tttagaaaaa ggcgacgaag taatggttct gattcctcag   1080

cttcaccgtg ataaaacaat ttggggagac gatgtggagg agttccgtcc agagcgtttt   1140

gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg   1200

tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa   1260

cactttgact ttgaagatca tacaaactac gagctcgata ttaaagaaac tttaacgtta   1320

aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct   1380

tcacctagca ctggacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat   1440

acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat   1500

ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac   1560

gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat   1620

ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta   1680

aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa   1740

aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac   1800

cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat   1860

atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa   1920

tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac   1980

ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga   2040

agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat   2100

ttaggtgtta ttcctcgcaa ctatgaagga acagtaaacc gtgtaacagc aaggttcggc   2160

ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca   2220

ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt   2280

acgcgcacgc agcttcgcgc aatggctgct aagacggtct gcccgccgca taaagtagag   2340

cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca   2400

atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc   2460

cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa   2520

aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa   2580

tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc   2640

tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc   2700

atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag   2760

ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct   2820

catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg   2880

cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg   2940

gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc   3000

ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac   3060

gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc   3120

cgatacgcaa aagacgtgtg ggctgggtaa gaattcatcg atgataagct gtcaaacatg   3180

agcagatctg agcccgccta atgagcgggc ttttttttca gatctgcttg aagacgaaag   3240

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagcgt   3300

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta   3360

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc   3420

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt   3480

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg   3540

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca   3600

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcgggct   3660

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga   3720

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt tcaggtggca   3780

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata   3840

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga   3900

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc   3960

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg   4020

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc   4080

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat   4140

cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact   4200

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat   4260

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga   4320

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc   4380

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga   4440

tgcctgcagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag   4500

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc   4560

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt   4620

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct   4680

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg   4740

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg   4800

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca   4860

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga   4920

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa   4980

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga   5040

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt   5100

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt   5160

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat   5220

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct   5280

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca   5340

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag   5400

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc   5460

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga   5520

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca   5580

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag   5640

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg   5700

aagagcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat   5760

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt atacactccg   5820

ctatcgctac gtgactgggt catggctgcg ccccgacacc cgccaacacc cgctgacgcg   5880

ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg   5940

agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgaggca gaacgccatc   6000

aaaaataatt cgcgtctggc cttcctgtag ccagctttca tcaacattaa atgtgagcga   6060

gtaacaaccc gtcggattct ccgtgggaac aaacggcgga ttgaccgtaa tgggataggt   6120

tacgttggtg tagatgggcg catcgtaacc gtgcatctgc cagtttgagg ggacgacgac   6180

agtatcggcc tcaggaagat cgcactccag ccagctttcc ggcaccgctt ctggtgccgg   6240

aaaccaggca aagcgccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt   6300

gcgggcctct tcgctattac gccagctggc gaaaggggga tgtgctgcaa ggcgattaag   6360

ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa acgacggcca gtgaatccgt   6420

aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca   6480

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat   6540

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt   6600

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgccag ggtggttttt   6660

cttttcacca gtgagacggg caacagctga ttgcccttca ccgcctggcc ctgagagagt   6720

tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa aatcctgttt gatggtggtt   6780

aacggcggga tataacatga gctgtcttcg gtatcgtcgt atcccactac cgagatatcc   6840

gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg cgcccagcgc catctgatcg   6900

ttggcaacca gcatcgcagt gggaacgatg ccctcattca gcatttgcat ggtttgttga   6960

aaaccggaca tggcactcca gtcgccttcc cgttccgcta tcggctgaat ttgattgcga   7020

gtgagatatt tatgccagcc agccagacgc agacgcgccg agacagaact taatgggccc   7080

gctaacagcg cgatttgctg gtgacccaat gcgaccagat gctccacgcc cagtcgcgta   7140

ccgtcttcat gggagaaaat aatactgttg atgggtgtct ggtcagagac atcaagaaat   7200

aacgccggaa cattagtgca ggcagcttcc acagcaatgg catcctggtc atccagcgga   7260

tagttaatga tcagcccact gacgcgttgc gcgagaagat tgtgcaccgc cgctttacag   7320

gcttcgacgc cgcttcgttc taccatcgac accaccacgc tggcacccag ttgatcggcg   7380

cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca gggccagact ggaggtggca   7440

acgccaatca gcaacgactg tttgcccgcc agttgttgtg ccacgcggtt gggaatgtaa   7500

ttcagctccg ccatcgccgc ttccactttt tcccgcgttt tcgcagaaac gtggctggcc   7560

tggttcacca cgcgggaaac ggtctgataa gagacaccgg catactctgc gacatcgtat   7620

aacgttactg gtttcacatt caccaccctg aattgactct cttccgggcg ctatcatgcc   7680

ataccgcgaa aggttttgcg ccattcgatg gtgtcctggc acgacaggtt tcccgactgg   7740

aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag   7800

gctttacact ttatgcttcc ggctcgtata atgtgtggaa ttgtgagcgg ataacaattt   7860

cacacaggaa acaggatcga tccatcgatg agcttactcc ccatccccct gttgacaatt   7920

aatcatcggc tcgtataatg tgtggaattg tgagcggata acaatttcac acaggaaaca   7980

ggatcagctt actccccatc cccctgttga caattaatca tcggctcgta taatgtgtgg   8040

aattgtgagc ggataacaat                                               8060


<210>  19
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  n is a, c, g, or t

<400>  19
gtcaannnct taaatttgca cg                                              22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  n is a, c, g, or t

<400>  20
gtcaagcgnn naaatttgca cg                                              22


<210>  21
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  n is a, c, g, or t

<400>  21
gcttaaattt nnncgtgatt ttgcagg                                         27


<210>  22
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  n is a, c, g, or t

<400>  22
cgtgatnnng caggagac                                                   18


<210>  23
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  n is a, c, g, or t

<400>  23
cgtgattttn nnggagac                                                   18


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  n is a, c, g, or t

<400>  24
gagacgggtt annnacaagc tggac                                           25


<210>  25
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  n is a, c, g, or t

<400>  25
ggagacgggt tatttnnnag ctggacg                                         27


<210>  26
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  n is a, c, g, or t

<400>  26
caaattattn nnttcttaat tgcgggac                                        28


<210>  27
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  n is a, c, g, or t

<400>  27
acattcttan nngcgggaca cgaaac                                          26


<210>  28
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  n is a, c, g, or t

<400>  28
acattcttaa ttnnnggaca cgaaac                                          26


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  n is a, c, g, or t

<400>  29
ccaactnnnc ctgcgttttc c                                               21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  30
ggaaacagga tccatcgatg c                                               21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  31
gtgaaggaat accgccaagc                                                 20


<210>  32
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  32
gcttaaattc rcgcgtgatt ttdbcggaga cg                                   32


<210>  33
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  33
cttaaattct ttcgtgattt tdbcggagac g                                    31


<210>  34
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  34
caaattatta cattcttaat tgcgggac                                        28


<210>  35
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  35
caaattatta acttcttaat tgcgggac                                        28


<210>  36
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  36
caaattattc ttttcttaat tgcgggac                                        28


<210>  37
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<400>  37
gagacgggtt antyacaagc tggac                                           25


<210>  38
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<400>  38
gagacgggtt antytgtagc tggac                                           25


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  39
ccaactgctc ctgcgttttc c                                               21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  40
ccaactbttc ctgcgttttc c                                               21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  41
ccaactatgc ctgcgttttc c                                               21


<210>  42
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  42
cttaagtcaa gcgmttaaat tc                                              22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  43
cttaagtcaa gcgtggaaat tc                                              22


<210>  44
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  44
gactttgaag atcatacaaa ctacgagctc g                                    31


<210>  45
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  45
agatctgctc atgtttgaca gcttatcatc gatgaattc                            39


<210>  46
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  46
cgcgctacat atcaagtcag c                                               21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  47
gctgacttga tatgtagcgc g                                               21


<210>  48
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  48
gtatcggaag acgcgacacg tttaacg                                         27


<210>  49
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  49
gtatcggaag acgcgacacg tttaacg                                         27


<210>  50
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  50
gaagatacga tgcttggagg ag                                              22


<210>  51
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  51
ctcctccaag catcgtatct tc                                              22


<210>  52
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  52
cgtgataaaa cagtttgggg agacg                                           25


<210>  53
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  53
cgtctcccca aactgtttta tcacg                                           25


<210>  54
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  54
cgttaaaacc taaaggcttt gtgg                                            24


<210>  55
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  55
ccacaaagcc tttaggtttt aacg                                            24


<210>  56
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  56
cgaagcgctg cgcatctggc caactt                                          26


<210>  57
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  57
aagttggcca gatgcgcagc gcttcg                                          26


<210>  58
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  58
cttacttcca aggttcagtc agcagg                                          26


<210>  59
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reversse primer

<400>  59
cctgctgact gaaccttgga agtaag                                          26


<210>  60
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  60
cacaggaaac aggatccatc gatgcttagg                                      30


<210>  61
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  61
ctaggtgaag gaataccgcc aagcgga                                         27


<210>  62
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  62
cgatattaaa gaaactnnka cgttaaaacc                                      30


<210>  63
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  63
ggttttaacg tmnnagtttc tttaatatcg                                      30


<210>  64
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  64
cgatattaaa gaaactttan nkttaaaacc                                      30


<210>  65
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  65
ggttttaamn ntaaagtttc tttaatatcg                                      30


<210>  66
<211>  30
<212>  DNA
<213>  Artificial primer

<220>
<223>  Reverse primer

<400>  66
ccgggctcag atctgctcat gtttgacagc                                      30


<210>  67
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  67
ggtccgtgca nnkgatgaag taatg                                           25


<210>  68
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  68
cattacttca tcmnntgcac ggacc                                           25


<210>  69
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  69
cgtgattttn nkggagacgg gtta                                            24


<210>  70
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  70
taacccgtct ccmnnaaaat cacg                                            24


<210>  71
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  71
aacttaagtc aannkcttaa attc                                            24


<210>  72
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  72
gaatttaagm nnttgactta agtt                                            24


<210>  73
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<400>  73
gtcaagcgnn kaaattcttt cgtg                                            24


<210>  74
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  74
cacgaaagaa tttmnncgct tgac                                            24


<210>  75
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  75
gtcaagcgct taaattcnnk cgtgatttt                                       29


<210>  76
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  76
aaaatcacgm nngaatttaa gcgcttgac                                       29


<210>  77
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<400>  77
ggccaactnn kcctgcgttt tcc                                             23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  78
ggaaaacgca ggmnnagttg gcc                                             23


<210>  79
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  79
gcactggatg aannkatgaa caag                                            24


<210>  80
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  80
cttgttcatm nnttcatcca gtgc                                            24


<210>  81
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  n is a, c, g, or t

<400>  81
gaacaagnnk cagcgagcaa atcc                                            24


<210>  82
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<400>  82
ggatttgctc gctgmnnctt gttc                                            24


<210>  83
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  83
gcgtgcgtgt nnkggtcagc ag                                              22


<210>  84
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  84
ctgctgaccm nnacacgcac gc                                              22


<210>  85
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  85
gcgggacacg aannkacaag tggtc                                           25


<210>  86
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is a, c, g, or t

<400>  86
gaccacttgt mnnttcgtgt cccgc                                           25


<210>  87
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  87
cattcttaat tgcgnnkcac gaaacaacaa gtg                                  33


<210>  88
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  88
cacttgttgt ttcgtgmnnc gcaattaaga atg                                  33


<210>  89
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is a, c, g, or t

<400>  89
cattcttaat tnnkggacac gaaacaacaa gtg                                  33


<210>  90
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<400>  90
cacttgttgt ttcgtgtccm nnaattaaga atg                                  33


<210>  91
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  91
caaattattn nkttcttaat tgcgggac                                        28


<210>  92
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  92
gtcccgcaat taagaamnna ataatttg                                        28


<210>  93
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<400>  93
gtcaagcgnn kaaatttgta cg                                              22


<210>  94
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  94
gtcccgcaat taagaamnna ataatttg                                        28


<210>  95
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  95
gacgggttat ttnnkagctg gacgcatg                                        28


<210>  96
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  96
gtcccgcaat taagaamnna ataatttg                                        28


<210>  97
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  97
gacgggttan nkacaagctg g                                               21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  98
ccagcttgtm nntaacccgt c                                               21


<210>  99
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  99
cgtgattttg gtggagacgg gtta                                            24


<210>  100
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  100
taacccgtct ccaccaaaat cacg                                            24


<210>  101
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  101
gctggtactt ggtatgatgc t                                               21


<210>  102
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  102
ccagacggat ttgctgtgat                                                 20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  103
cgtgtaacag caaggttcgg                                                 20


<210>  104
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  104
ctgctcatgt ttgacagctt atc                                             23


<210>  105
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  105
cgttaaaacc tgaannkttt gtgg                                            24


<210>  106
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<400>  106
ccacaaamnn ttcaggtttt aacg                                            24


<210>  107
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  107
cctgaaggct ttnnkgtaaa agca                                            24


<210>  108
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  108
tgcttttacm nnaaagcctt cagg                                            24


<210>  109
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  n is a, c, g, or t

<400>  109
cgctcataat nnkccgctgc ttgtg                                           25


<210>  110
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  110
cacaagcagc ggmnnattat gagcg                                           25


<210>  111
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primere


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  111
ccgcaggtcg cannkcttga ttcac                                           25


<210>  112
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is a, c, g, or t

<400>  112
gtgaatcaag mnntgcgacc tgcgg                                           25


<210>  113
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  113
gcggatatgn nkcttgcgaa aatg                                            24


<210>  114
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  114
cattttcgca agmnncatat ccgc                                            24


<210>  115
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  115
ggtgcgtttt cannkaacgt cgtagca                                         27


<210>  116
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<400>  116
tgctacgacg ttmnntgaaa acgcacc                                         27


<210>  117
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  117
caagaaggan nkcatttagg tg                                              22


<210>  118
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is a, c, g, or t

<400>  118
cacctaaatg mnntccttct tg                                              22


<210>  119
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer


<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  119
cagcagctag aannkaaagg ccg                                             23


<210>  120
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<400>  120
cggcctttmn nttctagctg ctg                                             23


<210>  121
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  121
gcagatattg caatgagcaa agg                                             23


<210>  122
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  122
cctttgctca ttgcaatatc tgc                                             23


<210>  123
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward primer

<400>  123
cggtctgccc gccgcataaa g                                               21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse primer

<400>  124
ctttatgcgg cgggcagacc g                                               21


<210>  125
<211>  1048
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutant sequence

<400>  125

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Cys Val 
        35                  40                  45              


Thr Arg Tyr Ile Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Glu Leu Lys Phe Phe Arg Asp 
65                  70                  75                  80  


Phe Gly Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Ile Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Ser Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Ile Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Val Met Asn Lys Pro Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Cys Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Arg Gly Glu Gln Ser Asp Asp Leu Leu Thr Gln Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Gly Asn Ile Ser Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Val Val Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Phe Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Val Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Val Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Ala Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Gly 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn Thr 
465                 470                 475                 480 


Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly Thr 
                485                 490                 495     


Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro Gln 
            500                 505                 510         


Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly Ala 
        515                 520                 525             


Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn Ala 
    530                 535                 540                 


Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val Lys 
545                 550                 555                 560 


Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala Thr 
                565                 570                 575     


Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala Lys 
            580                 585                 590         


Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp Asp 
        595                 600                 605             


Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp Val 
    610                 615                 620                 


Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu Ala 
                645                 650                 655     


Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu Leu 
            660                 665                 670         


Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu Leu 
        675                 680                 685             


Pro Lys Glu Ala Ser Tyr Gln Glu Gly Gly His Leu Gly Val Ile Pro 
    690                 695                 700                 


Arg Asn Tyr Glu Gly Thr Val Asn Arg Val Thr Ala Arg Phe Gly Leu 
705                 710                 715                 720 


Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu Ala 
                725                 730                 735     


His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln Tyr 
            740                 745                 750         


Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met Ala 
        755                 760                 765             


Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu Leu 
    770                 775                 780                 


Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr Met 
785                 790                 795                 800 


Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser Glu 
                805                 810                 815     


Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile Ser 
            820                 825                 830         


Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser Val 
        835                 840                 845             


Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile Ala 
    850                 855                 860                 


Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys Phe 
865                 870                 875                 880 


Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu Thr 
                885                 890                 895     


Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg Gly 
            900                 905                 910         


Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu Gly 
        915                 920                 925             


Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr Leu 
    930                 935                 940                 


Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr Leu 
945                 950                 955                 960 


His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val Gln 
                965                 970                 975     


His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp Gln 
            980                 985                 990         


Gly Ala His Phe Tyr Ile Cys Gly  Asp Gly Ser Gln Met  Ala Pro Ala 
        995                 1000                 1005             


Val Glu  Ala Thr Leu Met Lys  Ser Tyr Ala Asp Val  His Gln Val 
    1010                 1015                 1020             


Ser Glu  Ala Asp Ala Arg Leu  Trp Leu Gln Gln Leu  Glu Glu Lys 
    1025                 1030                 1035             


Gly Arg  Tyr Ala Lys Asp Val  Trp Ala Gly 
    1040                 1045             


