                        SEQUENCE LISTING

<110>  Roizman et al.
 
<120>  Separation of Receptor Binding and Pro-Fusogenic Domains of 
       Glycoprotein D of Herpes Simplex Virus 1 into Distinct 
       Interacting Proteins

<130>  27373/42553A

<140>  US 11/677,026
<141>  2007-02-20
          
<140>  US 11/215,636
<141>  2005-08-30

<140>  US 10/530,774
<141>  2005-04-07

<140>  PCT/US2003/31598
<141>  2003-10-06

<140>  US 60/416,716
<141>  2002-10-07

<140>  PCT/US2006/032291
<141>  2006-08-18

<140>  US 60/709,597
<141>  2005-08-19

<160>  74 

<170>  PatentIn version 3.3

<210>  1
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pIL13F1 primer

<400>  1
cattgctctc acttgccttg gcggctttgc ctccccaggc cctgtgcctc cctctacagc     60


<210>  2
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pIL13F2 primer

<400>  2
gcagctagcc tcatggcgct tttgttgacc acggtcattg ctctcacttg ccttggcggc     60

          
<210>  3
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pIL13REcoRI primer

<400>  3
gagctcggat cctgaattca accgtccctc                                      30


<210>  4
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pgC-F

<400>  4
gacacgggct accctcacta tcgagggc                                        28


<210>  5
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pgC-R

<400>  5
ggtgatgttc gtcaggacct cctctaggtc                                      30


<210>  6
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pgB1BamHI primer

<400>  6
gttcttcttc ggtttcggat cccccg                                          26


<210>  7
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pgB2BspEI primer

<400>  7
cggcatttcc ggaataacgc ccactc                                          26


<210>  8
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pgB3BamHI primer

<400>  8
cagaaaaccg gatcccccaa agccgcc                                         27


<210>  9
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pgB4BsiWI primer

<400>  9
gccaacacaa actcgtcgta cgggtac                                         27


<210>  10
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  first forward primer

<400>  10
cagttatcct taaggtctct tttgtgtggt g                                    31


<210>  11
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  first reverse primer

<400>  11
ccggaattcc ggagatcttc cctcgaggac cggaaggtct ttgccgcgaa ag             52


<210>  12
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  second forward primer

<400>  12
ccggaattcc ggggtaccct ggaccagctg accgaccctc cgg                       43


<210>  13
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  second reverse primer

<400>  13
cggggggatg cgcagcggga gggcgtactt ac                                   32


<210>  14
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13 forward primer

<400>  14
ccgctcgaga tggcgctttt gttgaccacg g                                    31


<210>  15
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13 reverse primer

<400>  15
ggggtaccgt tgaaccgtcc ctcgcgaaa                                       29


<210>  16
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL 13 ORF forward primer

<400>  16
ccgctcgaga tggcgctttt gttgaccacg g                                    31


<210>  17
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13 ORF reverse primer

<400>  17
ggggtaccgt tgaaccgtcc ctcgcgaaa                                       29


<210>  18
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13-gD forward junction primer

<400>  18
ccgctcgaga tggcgctttt gttgaccacg g                                    31


<210>  19
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13-gD reverse junction primer

<400>  19
aactgcaggt tgttcggggt ggccggggg                                       29


<210>  20
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13 2 forward primer

<400>  20
aagatttggg ctagcatggc tttcgtttgc                                      30


<210>  21
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13 2 reverse primer

<400>  21
tccctcgaag cttcaagcat aatctggcac atcatatgta tcacagaaaa a              51


<210>  22
<211>  568
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13-gC chimeric protein

<400>  22
gcttggtcgg gaggccgcat cgaacgcaca cccccatccg gtggtccgtg tggaggtcgt     60

ttttcagtgc ccggtctcgc tttgccggga acgctagcct catggcgctt ttgttgacca    120

cggtcattgc tctcacttgc cttggcggct ttgcctcccc aggccctgtg cctccctcta    180

cagccctcag gtacctcatt gaggagctgg tcaacatcac ccagaaccag aaggctccgc    240

tctgcaatgg cagcatggta tggagcatca acctgacagc tggcatgtac tgtgcagccc    300

tggaatccct gatcaacgtg tcaggctgca gtgccatcga gaagacccag aggatgctga    360

gcggattctg cccgcacaag gtctcagctg ggcagttttc cagcttgcat gtccgagaca    420

ccaaaatcga ggtggcccag tttgtaaaag atctgctctt acatttaaag aaactttttc    480

gcgagggacg gttgaattcc acccgcatgg agttccgcct ccagatatgg cgttactcca    540

tgggtccgtc ccccccaatc gctccggc                                       568


<210>  23
<211>  350
<212>  DNA
<213>  Artificial sequence

<220>
<223>  domain of the gB open reading frame (i.e., ORF) from which the 
       poly lysine [poly(K)] sequence was deleted

<400>  23
gggtcctggt ggcgtcggcg gctccgagtt cccccggcac gcctggggtc gcggccgcga     60

cccaggcggc gaacggggga cctgccactc cggcgccgcc cgcccctggc cccgccccaa    120

cgggggatcc gaaaccgaag aagaacagaa aaccgaaacc cccaaagcgc cgcgccccgc    180

cggcgacaac gcgaccgtcg ccgcgggcca cgccaccctg cgcgagcacc tgcgggacat    240

caaggcggag aacaccgatg caaactttta cgtgtgccca ccccccacgg gcgccacggt    300

ggtgcagttc gagcagccgc gccgctgccc gacccggccc gagggtcaga               350


<210>  24
<211>  655
<212>  DNA
<213>  Artificial sequence

<220>
<223>  amino-terminal sequence of IL13-gD

<400>  24
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtcggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagctggc cgaccccaat    120

cgctttcgcc gcaaagacct tccggtcctc gagatggcgc ttttgttgac cacggtcatt    180

gctctcactt gccttggcgg ctttgcctcc ccaggccctg tgcctcccct ctacagccct    240

cagggagctc attgaggagc tggtcaacat cacccagaac cagaaggctc cgctctgcaa    300

tggcagcatg gtttggagca tcaacctgac agctggcatg tactgtgcag ccctggaatc    360

cctgatcaac gtgtcaggct gcagtgccat cgagaagacc cagaggatgc tgggcggatt    420

ctgcccgcac aaggtctcag ctgggcagtt ttccagcttg catgtccgag acaccaaaat    480

cgaggtggcc cagtttgtaa aggacctgct cttacattta aagaaacttt ttcgcgaggg    540

acggttcaac tgaaacggta ccctggacca gctgaccgac cctccggggg tccggcgcgt    600

gtaccacatc caggcgggcc taccggaccc gttccagccc cccagcctcc cgatc         655


<210>  25
<211>  1185
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gD polynucleotide

<400>  25
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagatggc cgaccccaat    120

cgctttcgcg gcaaagacct tccggtcccg gaccggctga ccgaccctcc gggggtccgg    180

cgcgtgtacc acatccaggc gggcctaccg gacccgttcc agccccccag cctcccgatc    240

acggtttact acgccgtgtt ggagcgcgcc tgccgcagcg tgctcctaaa cgcaccgtcg    300

gaggcccccc agattgtccg cggggcctcc gaagacgtcc ggaaacaacc ctacaacctg    360

accatcgctt ggtttcggat gggaggcaac tgtgctatcc ccatcacggt catggagtac    420

accgaatgct cctacaacaa gtctctgggg gcctgtccca tccgaacgca gccccgctgg    480

aactactatg acagcttcag cgccgtcagc gaggataacc tggggttcct gatgcacgcc    540

cccgcgtttg agaccgccgg cacgtacctg cggctcgtga agataaacga ctggacggag    600

attacacagt ttatcctgga gcaccgagcc aagggctcct gtaagtacgc ccttccgctg    660

cgcatccccc cgtcagcctg cctctccccc caggcctacc agcagggggt gacggtggac    720

agcatcggga tgctgccccg cttcatcccc gagaaccagc gcaccgtcgc cgtatacagc    780

ttgaagatcg ccgggtggca cgggcccaag gccccataca cgagcaccct gctgcccccg    840

gagctgtccg agacccccaa cgccacgcag ccagaactcg ccccggaaga ccccgaggat    900

tcggccctct tggaggaccc cgtggggacg gtggtgccgc aaatcccacc aaactggcac    960

ataccgtcga tccaggacgc cgcgacgcct taccatcccc cggccacccc gaacaacatg   1020

ggcctgatcg ccggcgcggt gggcggcagt ctcctggtag ccctggtcat ttgcggaatt   1080

gtgtactgga tgcgccgccg cactcaaaaa gccccaaagc gcatacgcct cccccacatc   1140

cgggaagacg accagccgtc ctcgcaccag cccttgtttt actag                   1185


<210>  26
<211>  394
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gD amino acid

<400>  26

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Pro Asp Arg Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp 
            100                 105                 110         


Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly 
        115                 120                 125             


Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Val Gly Thr Val Val Pro Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr 
                325                 330                 335     


Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu 
            340                 345                 350         


Val Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr 
        355                 360                 365             


Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp 
    370                 375                 380                 


Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
385                 390                 


<210>  27
<211>  2715
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gB polynucleotide

<400>  27
atgcgccagg gcgcccccgc gcgggggcgc cggtggttcg tcgtatgggc gctcttgggg     60

ttgacgctgg gggtcctggt ggcgtcggcg gctccgagtt cccccggcac gcctggggtc    120

gcggccgcga cccaggcggc gaacgggggc cctgccactc cggcgccgcc cgcccctggc    180

gcccccccaa cgggggaccc gaaaccgaag aagaacagaa aaccgaaacc cccaaagccg    240

ccgcgccccg ccggcgacaa cgcgaccgtc gccgcgggcc acgccaccct gcgcgagcac    300

ctgcgggaca tcaaggcgga gaacaccgat gcaaactttt acgtgtgccc accccccacg    360

ggcgccacgg tggtgcagtt cgagcagccg cgccgctgcc cgacccggcc cgagggtcag    420

aactacacgg agggcatcgc ggtggtcttc aaggagaaca tcgccccgta caagttcaag    480

gccaccatgt actacaaaga cgtcaccgtt tcgcaggtgt ggttcggcca ccgctactcc    540

cagtttatgg ggatctttga ggaccgcgcc cccgtcccct tcgaggaggt gatcgacaag    600

atcaacgcca agggggtctg tcggtccacg gccaagtacg tgcgcaacaa cctggagacc    660

accgcgtttc accgggacga ccacgagacc gacatggagc tgaaaccggc caacgccgcg    720

acccgcacga gccggggctg gcacaccacc gacctcaagt acaacccctc gcgggtggag    780

gcgttccacc ggtacgggac gacggtaaac tgcatcgtcg aggaggtgga cgcgcgctcg    840

gtgtacccgt acgacgagtt tgtgttggcg actggcgact ttgtgtacat gtccccgttt    900

tacggctacc gggaggggtc gcacaccgaa cacaccagct acgccgccga ccgcttcaag    960

caggtcgacg gcttctacgc gcgcgacctc accaccaagg cccgggccac ggcgccgacc   1020

acccggaacc tgctcacgac ccccaagttc accgtggcct gggactgggt gccaaagcgc   1080

ccgtcggtct gcaccatgac caagtggcag gaggtggacg agatgctgcg ctccgagtac   1140

ggcggctcct tccgattctc ttccgacgcc atatccacca ccttcaccac caacctgacc   1200

gagtacccgc tctcgcgcgt ggacctgggg gactgcatcg gcaaggacgc ccgcgacgcc   1260

atggaccgca tcttcgcccg caggtacaac gcgacgcaca tcaaggtggg ccagccgcag   1320

tactacctgg ccaatggggg ctttctgatc gcgtaccagc cccttctcag caacacgctc   1380

gcggagctgt acgtgcggga acacctccgc gagcagagcc gcaagccccc aaaccccacg   1440

cccccgccgc ccggggccag cgccaacgcg tccgtggagc gcatcaagac cacctcctcc   1500

atcgagttcg ccaggctgca gtttacgtac aaccacatac agcgccatgt caacgatatg   1560

ttgggccgcg ttgccatcgc gtggtgcgag ctgcagaatc acgagctgac cctgtggaac   1620

gaggcccgca agctgaaccc caacgccatc gcctcggcca ccgtgggccg gcgggtgagc   1680

gcgcggatgc tcggcgacgt gatggccgtc tccacgtgcg tgccggtcgc cgcggacaac   1740

gtgatcgtcc aaaactcgat gcgcatcagc tcgcggcccg gggcctgcta cagccgcccc   1800

ctggtcagct ttcggtacga agaccagggc ccgttggtcg aggggcagct gggggagaac   1860

aacgagctgc ggctgacgcg cgatgcgatc gagccgtgca ccgtgggaca ccggcgctac   1920

ttcaccttcg gtgggggcta cgtgtacttc gaggagtacg cgtactccca ccagctgagc   1980

cgcgccgaca tcaccaccgt cagcaccttc atcgacctca acatcaccat gctggaggat   2040

cacgagtttg tccccctgga ggtgtacacc cgccacgaga tcaaggacag cggcctgctg   2100

gactacacgg aggtccagcg ccgcaaccag ctgcacgacc tgcgcttcgc cgacatcgac   2160

acggtcatcc acgccgacgc caacgccgcc atgtttgcgg gcctgggcgc gttcttcgag   2220

gggatgggcg acctggggcg cgcggtcggc aaggtggtga tgggcatcgt gggcggcgtg   2280

gtatcggccg tgtcgggcgt gtcctccttc atgtccaacc cctttggggc gctggccgtg   2340

ggtctgttgg tcctggccgg cctggcggcg gccttcttcg cctttcgcta cgtcatgcgg   2400

ctgcagagca accccatgaa ggccctgtac ccgctaacca ccaaggagct caagaacccc   2460

accaacccgg acgcgtccgg ggagggcgag gagggcggcg actttgacga ggccaagcta   2520

gccgaggccc gggagatgat acggtacatg gccctggtgt ctgccatgga gcgcacggaa   2580

cacaaggcca agaagaaggg cacgagcgcg ctgctcagcg ccaaggtcac cgacatggtc   2640

atgcgcaagc gccgcaacac caactacacc caagttccca acaaagacgg tgacgccgac   2700

gaggacgacc tgtga                                                    2715


<210>  28
<211>  904
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gB amino acid

<400>  28

Met Arg Gln Gly Ala Pro Ala Arg Gly Arg Arg Trp Phe Val Val Trp 
1               5                   10                  15      


Ala Leu Leu Gly Leu Thr Leu Gly Val Leu Val Ala Ser Ala Ala Pro 
            20                  25                  30          


Ser Ser Pro Gly Thr Pro Gly Val Ala Ala Ala Thr Gln Ala Ala Asn 
        35                  40                  45              


Gly Gly Pro Ala Thr Pro Ala Pro Pro Ala Pro Gly Ala Pro Pro Thr 
    50                  55                  60                  


Gly Asp Pro Lys Pro Lys Lys Asn Arg Lys Pro Lys Pro Pro Lys Pro 
65                  70                  75                  80  


Pro Arg Pro Ala Gly Asp Asn Ala Thr Val Ala Ala Gly His Ala Thr 
                85                  90                  95      


Leu Arg Glu His Leu Arg Asp Ile Lys Ala Glu Asn Thr Asp Ala Asn 
            100                 105                 110         


Phe Tyr Val Cys Pro Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu 
        115                 120                 125             


Gln Pro Arg Arg Cys Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu 
    130                 135                 140                 


Gly Ile Ala Val Val Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Ala Thr Met Tyr Tyr Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly 
                165                 170                 175     


His Arg Tyr Ser Gln Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val 
            180                 185                 190         


Pro Phe Glu Glu Val Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg 
        195                 200                 205             


Ser Thr Ala Lys Tyr Val Arg Asn Asn Leu Glu Thr Thr Ala Phe His 
    210                 215                 220                 


Arg Asp Asp His Glu Thr Asp Met Glu Leu Lys Pro Ala Asn Ala Ala 
225                 230                 235                 240 


Thr Arg Thr Ser Arg Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro 
                245                 250                 255     


Ser Arg Val Glu Ala Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile 
            260                 265                 270         


Val Glu Glu Val Asp Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val 
        275                 280                 285             


Leu Ala Thr Gly Asp Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg 
    290                 295                 300                 


Glu Gly Ser His Thr Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys 
305                 310                 315                 320 


Gln Val Asp Gly Phe Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala 
                325                 330                 335     


Thr Ala Pro Thr Thr Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val 
            340                 345                 350         


Ala Trp Asp Trp Val Pro Lys Arg Pro Ser Val Cys Thr Met Thr Lys 
        355                 360                 365             


Trp Gln Glu Val Asp Glu Met Leu Arg Ser Glu Tyr Gly Gly Ser Phe 
    370                 375                 380                 


Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr 
385                 390                 395                 400 


Glu Tyr Pro Leu Ser Arg Val Asp Leu Gly Asp Cys Ile Gly Lys Asp 
                405                 410                 415     


Ala Arg Asp Ala Met Asp Arg Ile Phe Ala Arg Arg Tyr Asn Ala Thr 
            420                 425                 430         


His Ile Lys Val Gly Gln Pro Gln Tyr Tyr Leu Ala Asn Gly Gly Phe 
        435                 440                 445             


Leu Ile Ala Tyr Gln Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr 
    450                 455                 460                 


Val Arg Glu His Leu Arg Glu Gln Ser Arg Lys Pro Pro Asn Pro Thr 
465                 470                 475                 480 


Pro Pro Pro Pro Gly Ala Ser Ala Asn Ala Ser Val Glu Arg Ile Lys 
                485                 490                 495     


Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His 
            500                 505                 510         


Ile Gln Arg His Val Asn Asp Met Leu Gly Arg Val Ala Ile Ala Trp 
        515                 520                 525             


Cys Glu Leu Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys 
    530                 535                 540                 


Leu Asn Pro Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser 
545                 550                 555                 560 


Ala Arg Met Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val 
                565                 570                 575     


Ala Ala Asp Asn Val Ile Val Gln Asn Ser Met Arg Ile Ser Ser Arg 
            580                 585                 590         


Pro Gly Ala Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp 
        595                 600                 605             


Gln Gly Pro Leu Val Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg 
    610                 615                 620                 


Leu Thr Arg Asp Ala Ile Glu Pro Cys Thr Val Gly His Arg Arg Tyr 
625                 630                 635                 640 


Phe Thr Phe Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser 
                645                 650                 655     


His Gln Leu Ser Arg Ala Asp Ile Thr Thr Val Ser Thr Phe Ile Asp 
            660                 665                 670         


Leu Asn Ile Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val 
        675                 680                 685             


Tyr Thr Arg His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu 
    690                 695                 700                 


Val Gln Arg Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp 
705                 710                 715                 720 


Thr Val Ile His Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Gly 
                725                 730                 735     


Ala Phe Phe Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val 
            740                 745                 750         


Val Met Gly Ile Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser 
        755                 760                 765             


Ser Phe Met Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val 
    770                 775                 780                 


Leu Ala Gly Leu Ala Ala Ala Phe Phe Ala Phe Arg Tyr Val Met Arg 
785                 790                 795                 800 


Leu Gln Ser Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu 
                805                 810                 815     


Leu Lys Asn Pro Thr Asn Pro Asp Ala Ser Gly Glu Gly Glu Glu Gly 
            820                 825                 830         


Gly Asp Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Lys 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ala Lys Val Thr Asp Met Val 
865                 870                 875                 880 


Met Arg Lys Arg Arg Asn Thr Asn Tyr Thr Gln Val Pro Asn Lys Asp 
                885                 890                 895     


Gly Asp Ala Asp Glu Asp Asp Leu 
            900                 


<210>  29
<211>  1800
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gC polynucleotide

<400>  29
agggcgcttg gtcgggaggc cgcatcgaac gcacaccccc atccggtggt ccgtgtggag     60

gtcgttttca tgcccggtct cgctttgtcg ggaacgctag ccggtccctc gcgaggggga    120

ggcgtcgggc atggccccgg ggcgggtggg ccttgccgtg gtcctgtgga gcctgttgtg    180

gctcggggcg ggggtggccg ggggctcgga aactgcctcc accgggccca cgatcaccgc    240

gggagcggtg acgaacgcga gcgaggcccc cacatcgggg tcccccgggt cagccgccag    300

cccggaagtc acccccacat cgaccccaaa ccccaacaat gtcacacaaa acaaaaccac    360

ccccaccgag ccggccagcc ccccaacaac ccccaagccc acctccacgc ccaaaagccc    420

ccccacgtcc acccccgacc ccaaacccaa gaacaacacc acccccgcca agtcgggccg    480

ccccactaaa ccccccgggc ccgtgtggtg cgaccgccgc gacccattgg cccggtacgg    540

ctcgtgggtg cagatccgat gccggttttg gaattccacc cgcatggagt tccgcctcca    600

gatatggcgt tactccatgg gtccgtcccc cccaatcgct ccggctcccg acctagagga    660

ggtcctgacg aacatcaccg ccccacccgg gggactcctg gtgtacgaca gcgcccccaa    720

cctgacggac ccccacgtgc tctgggcgga gggggccggc ccgggcgccg accctccgtt    780

gtattctgtc accgggccgc tgccgaccca gcggctgatt atcggcgagg tgacgcccgc    840

gacccaggga atgtattact tggcctgggg ccggatggac agcccgcacg agtacgggac    900

gtgggtgcgc gtccgcatgt tccgcccccc gtctctgacc ctccagcccc acgcggtgat    960

ggagggtcag ccgttcaagg cgacgtgcac ggccgccgcc tactacccgc gtaaccccgt   1020

ggagtttgtc tggttcgagg acgaccgcca ggtgtttaac ccgggccaga tcgacacgca   1080

gacgcacgag caccccgacg ggttcaccac agtctctacc gtgacctccg aggctgtcgg   1140

cggccaggtc cccccgcgga ccttcacctg ccagatgacg tggcaccgcg actccgtgac   1200

gttctcgcga cgcaatgcca ccgggctggc cctggtgctg ccgcggccaa ccatcaccat   1260

ggaatttggg gtccggcatg tggtctgcac ggccggctgc gtccccgagg gcgtgacgtt   1320

tgcctggttc ctgggggacg acccctcacc ggcggctaag tcggccgtta cggcccagga   1380

gtcgtgcgac caccccgggc tggctacggt ccggtccacc ctgcccattt cgtacgacta   1440

cagcgagtac atctgtcggt tgaccggata tccggccggg attcccgttc tagagcacca   1500

cggcagtcac cagcccccac ccagggaccc caccgagcgg caggtgatcg aggcgatcga   1560

gtgggtgggg attggaatcg gggttctcgc ggcgggggtc ctggtcgtaa cggcaatcgt   1620

gtacgtcgtc cgcacatcac agtcgcggca gcgtcatcgg cggtaacgcg agaccccccc   1680

gttacctttt taatatctat atagtttggt cccccctcta tcccgcccac cgctgggcgc   1740

tataaagccg ccaccctctc ttccctcagg tcatccttgg tcgatcccga acgacacacg   1800


<210>  30
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gC amino acid

<400>  30

Met Ala Pro Gly Arg Val Gly Leu Ala Val Val Leu Trp Gly Leu Leu 
1               5                   10                  15      


Trp Leu Gly Ala Gly Val Ala Gly Gly Ser Glu Thr Ala Ser Thr Gly 
            20                  25                  30          


Pro Thr Ile Thr Ala Gly Ala Val Thr Asn Ala Ser Glu Ala Pro Thr 
        35                  40                  45              


Ser Gly Ser Pro Gly Ser Ala Ala Ser Pro Glu Val Thr Pro Thr Ser 
    50                  55                  60                  


Thr Pro Asn Pro Asn Asn Val Thr Gln Asn Lys Thr Thr Pro Thr Glu 
65                  70                  75                  80  


Pro Ala Ser Pro Pro Thr Thr Pro Lys Pro Thr Ser Thr Pro Lys Ser 
                85                  90                  95      


Pro Pro Thr Ser Thr Pro Asp Pro Lys Pro Lys Asn Asn Thr Thr Pro 
            100                 105                 110         


Ala Lys Ser Gly Arg Pro Thr Lys Pro Pro Gly Pro Val Trp Cys Asp 
        115                 120                 125             


Arg Arg Asp Pro Leu Ala Arg Tyr Gly Ser Arg Val Gln Ile Arg Cys 
    130                 135                 140                 


Arg Phe Arg Asn Ser Thr Arg Met Glu Phe Arg Leu Gln Ile Trp Arg 
145                 150                 155                 160 


Tyr Ser Met Gly Pro Ser Pro Pro Ile Ala Pro Ala Pro Asp Leu Glu 
                165                 170                 175     


Glu Val Leu Thr Asn Ile Thr Ala Pro Pro Gly Gly Leu Leu Val Tyr 
            180                 185                 190         


Asp Ser Ala Pro Asn Leu Thr Asp Pro His Val Leu Trp Ala Glu Gly 
        195                 200                 205             


Ala Gly Pro Gly Ala Asp Pro Pro Leu Tyr Ser Val Thr Gly Pro Leu 
    210                 215                 220                 


Pro Thr Gln Arg Leu Ile Ile Gly Glu Val Thr Pro Ala Thr Gln Gly 
225                 230                 235                 240 


Met Tyr Tyr Leu Ala Trp Gly Arg Met Asp Ser Pro His Glu Tyr Gly 
                245                 250                 255     


Thr Trp Val Arg Val Arg Met Phe Arg Pro Pro Ser Leu Thr Leu Gln 
            260                 265                 270         


Pro His Ala Val Met Glu Gly Gln Pro Phe Lys Ala Thr Cys Thr Ala 
        275                 280                 285             


Ala Ala Tyr Tyr Pro Arg Asn Pro Val Glu Phe Asp Trp Phe Glu Asp 
    290                 295                 300                 


Asp Arg Gln Val Phe Asn Pro Gly Gln Ile Asp Thr Gln Thr His Glu 
305                 310                 315                 320 


His Pro Asp Gly Phe Thr Thr Val Ser Thr Val Thr Ser Glu Ala Val 
                325                 330                 335     


Gly Gly Gln Val Pro Pro Arg Thr Phe Thr Cys Gln Met Thr Trp His 
            340                 345                 350         


Arg Asp Ser Val Thr Phe Ser Arg Arg Asn Ala Thr Gly Leu Ala Leu 
        355                 360                 365             


Val Leu Pro Arg Pro Thr Ile Thr Met Glu Phe Gly Val Arg His Val 
    370                 375                 380                 


Val Cys Thr Ala Gly Cys Val Pro Glu Gly Val Thr Phe Ala Trp Phe 
385                 390                 395                 400 


Leu Gly Asp Asp Pro Ser Pro Ala Ala Lys Ser Ala Val Thr Ala Gln 
                405                 410                 415     


Glu Ser Cys Asp His Pro Gly Leu Ala Thr Val Arg Ser Thr Leu Pro 
            420                 425                 430         


Ile Ser Tyr Asp Tyr Ser Glu Tyr Ile Cys Arg Leu Thr Gly Tyr Pro 
        435                 440                 445             


Ala Gly Ile Pro Val Leu Glu His His Gly Ser His Gln Pro Pro Pro 
    450                 455                 460                 


Arg Asp Pro Thr Glu Arg Gln Val Ile Glu Ala Ile Glu Trp Val Gly 
465                 470                 475                 480 


Ile Gly Ile Gly Val Leu Ala Ala Gly Val Leu Val Val Thr Ala Ile 
                485                 490                 495     


Val Tyr Val Val Arg Thr Ser Gln Ser Arg Gln Arg His Arg Arg 
            500                 505                 510     


<210>  31
<211>  1282
<212>  DNA
<213>  Homo sapiens

<400>  31
aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg     60

cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc    120

ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga    180

accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca    240

tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga    300

cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct    360

tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt    420

taaagaaact ttttcgcgag ggacagttca actgaaactt cgaaagcatc attatttgca    480

gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc    540

ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct    600

gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg    660

tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac    720

ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg    780

tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca    840

cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg    900

gggattgggg aagactgtgg ctgctagcac ttggagccaa gggttcagag actcagggcc    960

ccagcactaa agcagtggac accaggagtc cctggtaata agtactgtgt acagaattct   1020

gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg   1080

cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt   1140

gtttttcctt gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac   1200

cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc   1260

agaaataaag ttggtgacag at                                            1282


<210>  32
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  32

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  33
<211>  1376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13R 2 polynucleotide

<400>  33
gtaagaacac tctcgtgagt ctaacggtct tccggatgaa ggctatttga agtcgccata     60

acctggtcag aagtgtgcct gtcggcgggg agagaggcaa tatcaaggtt ttaaatctcg    120

gagaaatggc tttcgtttgc ttggctatcg gatgcttata tacctttctg ataagcacaa    180

catttggctg tacttcatct tcagacaccg agataaaagt taaccctcct caggattttg    240

agatagtgga tcccggatac ttaggttatc tctatttgca atggcaaccc ccactgtctc    300

tggatcattt taaggaatgc acagtggaat atgaactaaa ataccgaaac attggtagtg    360

aaacatggaa gaccatcatt actaagaatc tacattacaa agatgggttt gatcttaaca    420

agggcattga agcgaagata cacacgcttt taccatggca atgcacaaat ggatcagaag    480

ttcaaagttc ctgggcagaa actacttatt ggatatcacc acaaggaatt ccagaaacta    540

aagttcagga tatggattgc gtatattaca attggcaata tttactctgt tcttggaaac    600

ctggcatagg tgtacttctt gataccaatt acaacttgtt ttactggtat gagggcttgg    660

atcatgcatt acagtgtgtt gattacatca aggctgatgg acaaaatata ggatgcagat    720

ttccctattt ggaggcatca gactataaag atttctatat ttgtgttaat ggatcatcag    780

agaacaagcc tatcagatcc agttatttca cttttcagct tcaaaatata gttaaacctt    840

tgccgccagt ctatcttact tttactcggg agagttcatg tgaaattaag ctgaaatgga    900

gcataccttt gggacctatt ccagcaaggt gttttgatta tgaaattgag atcagagaag    960

atgatactac cttggtgact gctacagttg aaaatgaaac atacaccttg aaaacaacaa   1020

atgaaacccg acaattatgc tttgtagtaa gaagcaaagt gaatatttat tgctcagatg   1080

acggaatttg gagtgagtgg agtgataaac aatgctggga aggtgaagac ctatcgaaga   1140

aaactttgct acgtttctgg ctaccatttg gtttcatctt aatattagtt atatttgtaa   1200

ccggtctgct tttgcgtaag ccaaacacct acccaaaaat gattccagaa tttttctgtg   1260

atacatgaag actttccata tcaagagaca tggtattgac tcaacagttt ccagtcatgg   1320

ccaaatgttc aatatgagtc tcaataaact gaatttttct tgcgaatgtt gaaaaa       1376


<210>  34
<211>  380
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL13R 2 amino acid

<400>  34

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  35
<211>  2685
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gB lacking polylysine tract, polynucleotide

<400>  35
atgcgccagg gcgcccccgc gcgggggcgc cggtggttcg tcgtatgggc gctcttgggg     60

ttgacgctgg gggtcctggt ggcgtcggcg gctccgagtt cccccggcac gcctggggtc    120

gcggccgcga cccaggcggc gaacgggggc cctgccactc cggcgccgcc cgcccctggc    180

gcccccccaa cgggggaccc gccaaagccg ccgcgccccg ccggcgacaa cgcgaccgtc    240

gccgcgggcc acgccaccct gcgcgagcac ctgcgggaca tcaaggcgga gaacaccgat    300

gcaaactttt acgtgtgccc accccccacg ggcgccacgg tggtgcagtt cgagcagccg    360

cgccgctgcc cgacccggcc cgagggtcag aactacacgg agggcatcgc ggtggtcttc    420

aaggagaaca tcgccccgta caagttcaag gccaccatgt actacaaaga cgtcaccgtt    480

tcgcaggtgt ggttcggcca ccgctactcc cagtttatgg ggatctttga ggaccgcgcc    540

cccgtcccct tcgaggaggt gatcgacaag atcaacgcca agggggtctg tcggtccacg    600

gccaagtacg tgcgcaacaa cctggagacc accgcgtttc accgggacga ccacgagacc    660

gacatggagc tgaaaccggc caacgccgcg acccgcacga gccggggctg gcacaccacc    720

gacctcaagt acaacccctc gcgggtggag gcgttccacc ggtacgggac gacggtaaac    780

tgcatcgtcg aggaggtgga cgcgcgctcg gtgtacccgt acgacgagtt tgtgttggcg    840

actggcgact ttgtgtacat gtccccgttt tacggctacc gggaggggtc gcacaccgaa    900

cacaccagct acgccgccga ccgcttcaag caggtcgacg gcttctacgc gcgcgacctc    960

accaccaagg cccgggccac ggcgccgacc acccggaacc tgctcacgac ccccaagttc   1020

accgtggcct gggactgggt gccaaagcgc ccgtcggtct gcaccatgac caagtggcag   1080

gaggtggacg agatgctgcg ctccgagtac ggcggctcct tccgattctc ttccgacgcc   1140

atatccacca ccttcaccac caacctgacc gagtacccgc tctcgcgcgt ggacctgggg   1200

gactgcatcg gcaaggacgc ccgcgacgcc atggaccgca tcttcgcccg caggtacaac   1260

gcgacgcaca tcaaggtggg ccagccgcag tactacctgg ccaatggggg ctttctgatc   1320

gcgtaccagc cccttctcag caacacgctc gcggagctgt acgtgcggga acacctccgc   1380

gagcagagcc gcaagccccc aaaccccacg cccccgccgc ccggggccag cgccaacgcg   1440

tccgtggagc gcatcaagac cacctcctcc atcgagttcg ccaggctgca gtttacgtac   1500

aaccacatac agcgccatgt caacgatatg ttgggccgcg ttgccatcgc gtggtgcgag   1560

ctgcagaatc acgagctgac cctgtggaac gaggcccgca agctgaaccc caacgccatc   1620

gcctcggcca ccgtgggccg gcgggtgagc gcgcggatgc tcggcgacgt gatggccgtc   1680

tccacgtgcg tgccggtcgc cgcggacaac gtgatcgtcc aaaactcgat gcgcatcagc   1740

tcgcggcccg gggcctgcta cagccgcccc ctggtcagct ttcggtacga agaccagggc   1800

ccgttggtcg aggggcagct gggggagaac aacgagctgc ggctgacgcg cgatgcgatc   1860

gagccgtgca ccgtgggaca ccggcgctac ttcaccttcg gtgggggcta cgtgtacttc   1920

gaggagtacg cgtactccca ccagctgagc cgcgccgaca tcaccaccgt cagcaccttc   1980

atcgacctca acatcaccat gctggaggat cacgagtttg tccccctgga ggtgtacacc   2040

cgccacgaga tcaaggacag cggcctgctg gactacacgg aggtccagcg ccgcaaccag   2100

ctgcacgacc tgcgcttcgc cgacatcgac acggtcatcc acgccgacgc caacgccgcc   2160

atgtttgcgg gcctgggcgc gttcttcgag gggatgggcg acctggggcg cgcggtcggc   2220

aaggtggtga tgggcatcgt gggcggcgtg gtatcggccg tgtcgggcgt gtcctccttc   2280

atgtccaacc cctttggggc gctggccgtg ggtctgttgg tcctggccgg cctggcggcg   2340

gccttcttcg cctttcgcta cgtcatgcgg ctgcagagca accccatgaa ggccctgtac   2400

ccgctaacca ccaaggagct caagaacccc accaacccgg acgcgtccgg ggagggcgag   2460

gagggcggcg actttgacga ggccaagcta gccgaggccc gggagatgat acggtacatg   2520

gccctggtgt ctgccatgga gcgcacggaa cacaaggcca agaagaaggg cacgagcgcg   2580

ctgctcagcg ccaaggtcac cgacatggtc atgcgcaagc gccgcaacac caactacacc   2640

caagttccca acaaagacgg tgacgccgac gaggacgacc tgtga                   2685


<210>  36
<211>  894
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gB lacking polylysine tract, amino acid

<400>  36

Met Arg Gln Gly Ala Pro Ala Arg Gly Arg Arg Trp Phe Val Val Trp 
1               5                   10                  15      


Ala Leu Leu Gly Leu Thr Leu Gly Val Leu Val Ala Ser Ala Ala Pro 
            20                  25                  30          


Ser Ser Pro Gly Thr Pro Gly Val Ala Ala Ala Thr Gln Ala Ala Asn 
        35                  40                  45              


Gly Gly Pro Ala Thr Pro Ala Pro Pro Ala Pro Gly Ala Pro Pro Thr 
    50                  55                  60                  


Gly Asp Pro Pro Lys Pro Pro Arg Pro Ala Gly Asp Asn Ala Thr Val 
65                  70                  75                  80  


Ala Ala Gly His Ala Thr Leu Arg Glu His Leu Arg Asp Ile Lys Ala 
                85                  90                  95      


Glu Asn Thr Asp Ala Asn Phe Tyr Val Cys Pro Pro Pro Thr Gly Ala 
            100                 105                 110         


Thr Val Val Gln Phe Glu Gln Pro Arg Arg Cys Pro Thr Arg Pro Glu 
        115                 120                 125             


Gly Gln Asn Tyr Thr Glu Gly Ile Ala Val Val Phe Lys Glu Asn Ile 
    130                 135                 140                 


Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr Lys Asp Val Thr Val 
145                 150                 155                 160 


Ser Gln Val Trp Phe Gly His Arg Tyr Ser Gln Phe Met Gly Ile Phe 
                165                 170                 175     


Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val Ile Asp Lys Ile Asn 
            180                 185                 190         


Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr Val Arg Asn Asn Leu 
        195                 200                 205             


Glu Thr Thr Ala Phe His Arg Asp Asp His Glu Thr Asp Met Glu Leu 
    210                 215                 220                 


Lys Pro Ala Asn Ala Ala Thr Arg Thr Ser Arg Gly Trp His Thr Thr 
225                 230                 235                 240 


Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala Phe His Arg Tyr Gly 
                245                 250                 255     


Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp Ala Arg Ser Val Tyr 
            260                 265                 270         


Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp Phe Val Tyr Met Ser 
        275                 280                 285             


Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr Glu His Thr Ser Tyr 
    290                 295                 300                 


Ala Ala Asp Arg Phe Lys Gln Val Asp Gly Phe Tyr Ala Arg Asp Leu 
305                 310                 315                 320 


Thr Thr Lys Ala Arg Ala Thr Ala Pro Thr Thr Arg Asn Leu Leu Thr 
                325                 330                 335     


Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val Pro Lys Arg Pro Ser 
            340                 345                 350         


Val Cys Thr Met Thr Lys Trp Gln Glu Val Asp Glu Met Leu Arg Ser 
        355                 360                 365             


Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr 
    370                 375                 380                 


Phe Thr Thr Asn Leu Thr Glu Tyr Pro Leu Ser Arg Val Asp Leu Gly 
385                 390                 395                 400 


Asp Cys Ile Gly Lys Asp Ala Arg Asp Ala Met Asp Arg Ile Phe Ala 
                405                 410                 415     


Arg Arg Tyr Asn Ala Thr His Ile Lys Val Gly Gln Pro Gln Tyr Tyr 
            420                 425                 430         


Leu Ala Asn Gly Gly Phe Leu Ile Ala Tyr Gln Pro Leu Leu Ser Asn 
        435                 440                 445             


Thr Leu Ala Glu Leu Tyr Val Arg Glu His Leu Arg Glu Gln Ser Arg 
    450                 455                 460                 


Lys Pro Pro Asn Pro Thr Pro Pro Pro Pro Gly Ala Ser Ala Asn Ala 
465                 470                 475                 480 


Ser Val Glu Arg Ile Lys Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu 
                485                 490                 495     


Gln Phe Thr Tyr Asn His Ile Gln Arg His Val Asn Asp Met Leu Gly 
            500                 505                 510         


Arg Val Ala Ile Ala Trp Cys Glu Leu Gln Asn His Glu Leu Thr Leu 
        515                 520                 525             


Trp Asn Glu Ala Arg Lys Leu Asn Pro Asn Ala Ile Ala Ser Ala Thr 
    530                 535                 540                 


Val Gly Arg Arg Val Ser Ala Arg Met Leu Gly Asp Val Met Ala Val 
545                 550                 555                 560 


Ser Thr Cys Val Pro Val Ala Ala Asp Asn Val Ile Val Gln Asn Ser 
                565                 570                 575     


Met Arg Ile Ser Ser Arg Pro Gly Ala Cys Tyr Ser Arg Pro Leu Val 
            580                 585                 590         


Ser Phe Arg Tyr Glu Asp Gln Gly Pro Leu Val Glu Gly Gln Leu Gly 
        595                 600                 605             


Glu Asn Asn Glu Leu Arg Leu Thr Arg Asp Ala Ile Glu Pro Cys Thr 
    610                 615                 620                 


Val Gly His Arg Arg Tyr Phe Thr Phe Gly Gly Gly Tyr Val Tyr Phe 
625                 630                 635                 640 


Glu Glu Tyr Ala Tyr Ser His Gln Leu Ser Arg Ala Asp Ile Thr Thr 
                645                 650                 655     


Val Ser Thr Phe Ile Asp Leu Asn Ile Thr Met Leu Glu Asp His Glu 
            660                 665                 670         


Phe Val Pro Leu Glu Val Tyr Thr Arg His Glu Ile Lys Asp Ser Gly 
        675                 680                 685             


Leu Leu Asp Tyr Thr Glu Val Gln Arg Arg Asn Gln Leu His Asp Leu 
    690                 695                 700                 


Arg Phe Ala Asp Ile Asp Thr Val Ile His Ala Asp Ala Asn Ala Ala 
705                 710                 715                 720 


Met Phe Ala Gly Leu Gly Ala Phe Phe Glu Gly Met Gly Asp Leu Gly 
                725                 730                 735     


Arg Ala Val Gly Lys Val Val Met Gly Ile Val Gly Gly Val Val Ser 
            740                 745                 750         


Ala Val Ser Gly Val Ser Ser Phe Met Ser Asn Pro Phe Gly Ala Leu 
        755                 760                 765             


Ala Val Gly Leu Leu Val Leu Ala Gly Leu Ala Ala Ala Phe Phe Ala 
    770                 775                 780                 


Phe Arg Tyr Val Met Arg Leu Gln Ser Asn Pro Met Lys Ala Leu Tyr 
785                 790                 795                 800 


Pro Leu Thr Thr Lys Glu Leu Lys Asn Pro Thr Asn Pro Asp Ala Ser 
                805                 810                 815     


Gly Glu Gly Glu Glu Gly Gly Asp Phe Asp Glu Ala Lys Leu Ala Glu 
            820                 825                 830         


Ala Arg Glu Met Ile Arg Tyr Met Ala Leu Val Ser Ala Met Glu Arg 
        835                 840                 845             


Thr Glu His Lys Ala Lys Lys Lys Gly Thr Ser Ala Leu Leu Ser Ala 
    850                 855                 860                 


Lys Val Thr Asp Met Val Met Arg Lys Arg Arg Asn Thr Asn Tyr Thr 
865                 870                 875                 880 


Gln Val Pro Asn Lys Asp Gly Asp Ala Asp Glu Asp Asp Leu 
                885                 890                 


<210>  37
<211>  1626
<212>  DNA
<213>  Herpes Simplex Virus-1

<400>  37
atggcgcttt tgttgaccac ggtcattgct ctcacttgcc ttggcggctt tgcctcccca     60

ggccctgtgc ctccctctac agccctcagg gagctcattg aggagctggt caacatcacc    120

cagaaccaga aggctccgct ctgcaatggc agcatggtat ggagcatcaa cctgacagct    180

ggcatgtact gtgcagccct ggaatccctg atcaacgtgt caggctgcag tgccatcgag    240

aagacccaga ggatgctgag cggattctgc ccgcacaagg tctcagctgg gcagttttcc    300

agcttgcatg tccgagacac caaaatcgag gtggcccagt ttgtaaagga cctgctctta    360

catttaaaga aactttttcg cgagggacag ttcaacgaat tccacccgca tggagttccg    420

cctccagata tggcgttact ccatgggtcc gtccccccca atcgctccgg ctcccgacct    480

agaggaggtc ctgacgaaca tcaccgcccc acccggggga ctcctggtgt acgacagcgc    540

ccccaacctg acggaccccc acgtgctctg ggcggagggg gccggcccgg gcgccgaccc    600

tccgttgtat tctgtcaccg ggccgctgcc gacccagcgg ctgattatcg gcgaggtgac    660

gcccgcgacc cagggaatgt attacttggc ctggggccgg atggacagcc cgcacgagta    720

cgggacgtgg gtgcgcgtcc gcatgttccg ccccccgtct ctgaccctcc agccccacgc    780

ggtgatggag ggtcagccgt tcaaggcgac gtgcacggcc gccgcctact acccgcgtaa    840

ccccgtggag tttgtctggt tcgaggacga ccgccaggtg tttaacccgg gccagatcga    900

cacgcagacg cacgagcacc ccgacgggtt caccacagtc tctaccgtga cctccgaggc    960

tgtcggcggc caggtccccc cgcggacctt cacctgccag atgacgtggc accgcgactc   1020

cgtgacgttc tcgcgacgca atgccaccgg gctggccctg gtgctgccgc ggccaaccat   1080

caccatggaa tttggggtcc ggcatgtggt ctgcacggcc ggctgcgtcc ccgagggcgt   1140

gacgtttgcc tggttcctgg gggacgaccc ctcaccggcg gctaagtcgg ccgttacggc   1200

ccaggagtcg tgcgaccacc ccgggctggc tacggtccgg tccaccctgc ccatttcgta   1260

cgactacagc gagtacatct gtcggttgac cggatatccg gccgggattc ccgttctaga   1320

gcaccacggc agtcaccagc ccccacccag ggaccccacc gagcggcagg tgatcgaggc   1380

gatcgagtgg gtggggattg gaatcggggt tctcgcggcg ggggtcctgg tcgtaacggc   1440

aatcgtgtac gtcgtccgca catcacagtc gcggcagcgt catcggcggt aacgcgagac   1500

ccccccgtta cctttttaat atctatatag tttggtcccc cctctatccc gcccaccgct   1560

gggcgctata aagccgccac cctctcttcc ctcaggtcat ccttggtcga tcccgaacga   1620

cacacg                                                              1626


<210>  38
<211>  497
<212>  PRT
<213>  Herpes Simplex Virus-1

<400>  38

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Gln Phe Asn Glu Phe Ser Thr Arg Met Glu Phe Arg Leu Gln Ile 
    130                 135                 140                 


Trp Arg Tyr Ser Met Gly Pro Ser Pro Pro Ile Ala Pro Ala Pro Asp 
145                 150                 155                 160 


Leu Glu Glu Val Leu Thr Asn Ile Thr Ala Pro Pro Gly Gly Leu Leu 
                165                 170                 175     


Val Tyr Asp Ser Ala Pro Asn Leu Thr Asp Pro His Val Leu Trp Ala 
            180                 185                 190         


Glu Gly Ala Gly Pro Gly Ala Asp Pro Pro Leu Tyr Ser Val Thr Gly 
        195                 200                 205             


Pro Leu Pro Thr Gln Arg Leu Ile Ile Gly Glu Val Thr Pro Ala Thr 
    210                 215                 220                 


Gln Gly Met Tyr Tyr Leu Ala Trp Gly Arg Met Asp Ser Pro His Glu 
225                 230                 235                 240 


Tyr Gly Thr Trp Val Arg Val Arg Met Phe Arg Pro Pro Ser Leu Thr 
                245                 250                 255     


Leu Gln Pro His Ala Val Met Glu Gly Gln Pro Phe Lys Ala Thr Cys 
            260                 265                 270         


Thr Ala Ala Ala Tyr Tyr Pro Arg Asn Pro Val Glu Phe Asp Trp Phe 
        275                 280                 285             


Glu Asp Asp Arg Gln Val Phe Asn Pro Gly Gln Ile Asp Thr Gln Thr 
    290                 295                 300                 


His Glu His Pro Asp Gly Phe Thr Thr Val Ser Thr Val Thr Ser Glu 
305                 310                 315                 320 


Ala Val Gly Gly Gln Val Pro Pro Arg Thr Phe Thr Cys Gln Met Thr 
                325                 330                 335     


Trp His Arg Asp Ser Val Thr Phe Ser Arg Arg Asn Ala Thr Gly Leu 
            340                 345                 350         


Ala Leu Val Leu Pro Arg Pro Thr Ile Thr Met Glu Phe Gly Val Arg 
        355                 360                 365             


His Val Val Cys Thr Ala Gly Cys Val Pro Glu Gly Val Thr Phe Ala 
    370                 375                 380                 


Trp Phe Leu Gly Asp Asp Pro Ser Pro Ala Ala Lys Ser Ala Val Thr 
385                 390                 395                 400 


Ala Gln Glu Ser Cys Asp His Pro Gly Leu Ala Thr Val Arg Ser Thr 
                405                 410                 415     


Leu Pro Ile Ser Tyr Asp Tyr Ser Glu Tyr Ile Cys Arg Leu Thr Gly 
            420                 425                 430         


Tyr Pro Ala Gly Ile Pro Val Leu Glu His His Gly Ser His Gln Pro 
        435                 440                 445             


Pro Pro Arg Asp Pro Thr Glu Arg Gln Val Ile Glu Ala Ile Glu Trp 
    450                 455                 460                 


Val Gly Ile Gly Ile Gly Val Leu Ala Ala Gly Val Leu Val Val Thr 
465                 470                 475                 480 


Ala Ile Val Tyr Val Val Arg Thr Ser Gln Ser Arg Gln Arg His Arg 
                485                 490                 495     


Arg 
    


<210>  39
<211>  1593
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gD-IL13 integration polynucleotide

<400>  39
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagatggc cgaccccaat    120

cgctttcgcg gcaaagacct tccggtcctc gagatggcgc ttttgttgac cacggtcatt    180

gctctcactt gccttggcgg ctttgcctcc ccaggccctg tgcctccctc tacagccctc    240

agggagctca ttgaggagct ggtcaacatc acccagaacc agaaggctcc gctctgcaat    300

ggcagcatgg tatggagcat caacctgaca gctggcatgt actgtgcagc cctggaatcc    360

ctgatcaacg tgtcaggctg cagtgccatc gagaagaccc agaggatgct gagcggattc    420

tgcccgcaca aggtctcagc tgggcagttt tccagcttgc atgtccgaga caccaaaatc    480

gaggtggccc agtttgtaaa ggacctgctc ttacatttaa agaaactttt tcgcgaggga    540

cagttcaacg gtaccctgga ccggctgacc gaccctccgg gggtccggcg cgtgtaccac    600

atccaggcgg gcctaccgga cccgttccag ccccccagcc tcccgatcac ggtttactac    660

gccgtgttgg agcgcgcctg ccgcagcgtg ctcctaaacg caccgtcgga ggccccccag    720

attgtccgcg gggcctccga agacgtccgg aaacaaccct acaacctgac catcgcttgg    780

tttcggatgg gaggcaactg tgctatcccc atcacggtca tggagtacac cgaatgctcc    840

tacaacaagt ctctgggggc ctgtcccatc cgaacgcagc cccgctggaa ctactatgac    900

agcttcagcg ccgtcagcga ggataacctg gggttcctga tgcacgcccc cgcgtttgag    960

accgccggca cgtacctgcg gctcgtgaag ataaacgact ggacggagat tacacagttt   1020

atcctggagc accgagccaa gggctcctgt aagtacgccc ttccgctgcg catccccccg   1080

tcagcctgcc tctcccccca ggcctaccag cagggggtga cggtggacag catcgggatg   1140

ctgccccgct tcatccccga gaaccagcgc accgtcgccg tatacagctt gaagatcgcc   1200

gggtggcacg ggcccaaggc cccatacacg agcaccctgc tgcccccgga gctgtccgag   1260

acccccaacg ccacgcagcc agaactcgcc ccggaagacc ccgaggattc ggccctcttg   1320

gaggaccccg tggggacggt ggtgccgcaa atcccaccaa actggcacat accgtcgatc   1380

caggacgccg cgacgcctta ccatcccccg gccaccccga acaacatggg cctgatcgcc   1440

ggcgcggtgg gcggcagtct cctggtagcc ctggtcattt gcggaattgt gtactggatg   1500

cgccgccgca ctcaaaaagc cccaaagcgc atacgcctcc cccacatccg ggaagacgac   1560

cagccgtcct cgcaccagcc cttgttttac tag                                1593


<210>  40
<211>  530
<212>  PRT
<213>  Artificial sequence

<220>
<223>  gD-IL13 integration amino acid

<400>  40

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Glu Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys 
    50                  55                  60                  


Leu Gly Gly Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu 
65                  70                  75                  80  


Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala 
                85                  90                  95      


Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly 
            100                 105                 110         


Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
        115                 120                 125             


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
    130                 135                 140                 


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
145                 150                 155                 160 


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
                165                 170                 175     


Phe Arg Glu Gly Gln Phe Asn Gly Thr Pro Asp Arg Leu Thr Asp Pro 
            180                 185                 190         


Pro Gly Val Arg Arg Val Tyr His Ile Gln Ala Gly Leu Pro Asp Pro 
        195                 200                 205             


Phe Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu 
    210                 215                 220                 


Arg Ala Cys Arg Ser Val Leu Leu Asn Ala Pro Ser Glu Ala Pro Gln 
225                 230                 235                 240 


Ile Val Arg Gly Ala Ser Glu Asp Val Arg Lys Gln Pro Tyr Asn Leu 
                245                 250                 255     


Thr Ile Ala Trp Phe Arg Met Gly Gly Asn Cys Ala Ile Pro Ile Thr 
            260                 265                 270         


Val Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys Ser Leu Gly Ala Cys 
        275                 280                 285             


Pro Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr Asp Ser Phe Ser Ala 
    290                 295                 300                 


Val Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu 
305                 310                 315                 320 


Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu 
                325                 330                 335     


Ile Thr Gln Phe Ile Leu Glu His Arg Ala Lys Gly Ser Cys Lys Tyr 
            340                 345                 350         


Ala Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys Leu Ser Pro Gln Ala 
        355                 360                 365             


Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe 
    370                 375                 380                 


Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr Ser Leu Lys Ile Ala 
385                 390                 395                 400 


Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser Thr Leu Leu Pro Pro 
                405                 410                 415     


Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro Glu Leu Ala Pro Glu 
            420                 425                 430         


Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Val Gly Thr Val Val 
        435                 440                 445             


Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Ala Ala 
    450                 455                 460                 


Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn Met Gly Leu Ile Ala 
465                 470                 475                 480 


Gly Ala Val Gly Gly Ser Leu Leu Val Ala Leu Val Ile Cys Gly Ile 
                485                 490                 495     


Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala Pro Lys Arg Ile Arg 
            500                 505                 510         


Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser Ser His Gln Pro Leu 
        515                 520                 525             


Phe Tyr 
    530 


<210>  41
<211>  1416
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13-gD V34S polynucleotide

<400>  41
atggcgcttt tgttgaccac ggtcattgct ctcacttgcc ttggcggctt tgcctcccca     60

ggccctgtgc ctccctctac agccctcagg gagctcattg aggagctggt caacatcacc    120

cagaaccaga aggctccgct ctgcaatggc agcatggtat ggagcatcaa cctgacagct    180

ggcatgtact gtgcagccct ggaatccctg atcaacgtgt caggctgcag tgccatcgag    240

aagacccaga ggatgctgag cggattctgc ccgcacaagg tctcagctgg gcagttttcc    300

agcttgcatg tccgagacac caaaatcgag gtggcccagt ttgtaaagga cctgctctta    360

catttaaaga aactttttcg cgagggacag ttcaacggta ccgggtcccg gcgcgtgtac    420

cacatccagg cgggcctacc ggacccgttc cagcccccca gcctcccgat cacggtttac    480

tacgccgtgt tggagcgcgc ctgccgcagc gtgctcctaa acgcaccgtc ggaggccccc    540

cagattgtcc gcggggcctc cgaagacgtc cggaaacaac cctacaacct gaccatcgct    600

tggtttcgga tgggaggcaa ctgtgctatc cccatcacgg tcatggagta caccgaatgc    660

tcctacaaca agtctctggg ggcctgtccc atccgaacgc agccccgctg gaactactat    720

gacagcttca gcgccgtcag cgaggataac ctggggttcc tgatgcacgc ccccgcgttt    780

gagaccgccg gcacgtacct gcggctcgtg aagataaacg actggacgga gattacacag    840

tttatcctgg agcaccgagc caagggctcc tgtaagtacg cccttccgct gcgcatcccc    900

ccgtcagcct gcctctcccc ccaggcctac cagcaggggg tgacggtgga cagcatcggg    960

atgctgcccc gcttcatccc cgagaaccag cgcaccgtcg ccgtatacag cttgaagatc   1020

gccgggtggc acgggcccaa ggccccatac acgagcaccc tgctgccccc ggagctgtcc   1080

gagaccccca acgccacgca gccagaactc gccccggaag accccgagga ttcggccctc   1140

ttggaggacc ccgtggggac ggtggtgccg caaatcccac caaactggca cataccgtcg   1200

atccaggacg ccgcgacgcc ttaccatccc ccggccaccc cgaacaacat gggcctgatc   1260

gccggcgcgg tgggcggcag tctcctggta gccctggtca tttgcggaat tgtgtactgg   1320

atgcgccgcc gcactcaaaa agccccaaag cgcatacgcc tcccccacat ccgggaagac   1380

gaccagccgt cctcgcacca gcccttgttt tactag                             1416


<210>  42
<211>  471
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL13-gD V34S amino acid

<400>  42

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Gln Phe Asn Gly Thr Gly Ser Arg Arg Val Tyr His Ile Gln Ala 
    130                 135                 140                 


Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr 
145                 150                 155                 160 


Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Asn Ala Pro 
                165                 170                 175     


Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp Val Arg Lys 
            180                 185                 190         


Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly Gly Asn Cys 
        195                 200                 205             


Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys 
    210                 215                 220                 


Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr 
225                 230                 235                 240 


Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met His 
                245                 250                 255     


Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile 
            260                 265                 270         


Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His Arg Ala Lys 
        275                 280                 285             


Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys 
    290                 295                 300                 


Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly 
305                 310                 315                 320 


Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr 
                325                 330                 335     


Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser 
            340                 345                 350         


Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro 
        355                 360                 365             


Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro 
    370                 375                 380                 


Val Gly Thr Val Val Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser 
385                 390                 395                 400 


Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn 
                405                 410                 415     


Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Val Ala Leu 
            420                 425                 430         


Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala 
        435                 440                 445             


Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser 
    450                 455                 460                 


Ser His Gln Pro Leu Phe Tyr 
465                 470     


<210>  43
<211>  1416
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL13-gD V37S polynucleotide

<400>  43
atggcgcttt tgttgaccac ggtcattgct ctcacttgcc ttggcggctt tgcctcccca     60

ggccctgtgc ctccctctac agccctcagg gagctcattg aggagctggt caacatcacc    120

cagaaccaga aggctccgct ctgcaatggc agcatggtat ggagcatcaa cctgacagct    180

ggcatgtact gtgcagccct ggaatccctg atcaacgtgt caggctgcag tgccatcgag    240

aagacccaga ggatgctgag cggattctgc ccgcacaagg tctcagctgg gcagttttcc    300

agcttgcatg tccgagacac caaaatcgag gtggcccagt ttgtaaagga cctgctctta    360

catttaaaga aactttttcg cgagggacag ttcaacggta ccggggtccg gcgctcgtac    420

cacatccagg cgggcctacc ggacccgttc cagcccccca gcctcccgat cacggtttac    480

tacgccgtgt tggagcgcgc ctgccgcagc gtgctcctaa acgcaccgtc ggaggccccc    540

cagattgtcc gcggggcctc cgaagacgtc cggaaacaac cctacaacct gaccatcgct    600

tggtttcgga tgggaggcaa ctgtgctatc cccatcacgg tcatggagta caccgaatgc    660

tcctacaaca agtctctggg ggcctgtccc atccgaacgc agccccgctg gaactactat    720

gacagcttca gcgccgtcag cgaggataac ctggggttcc tgatgcacgc ccccgcgttt    780

gagaccgccg gcacgtacct gcggctcgtg aagataaacg actggacgga gattacacag    840

tttatcctgg agcaccgagc caagggctcc tgtaagtacg cccttccgct gcgcatcccc    900

ccgtcagcct gcctctcccc ccaggcctac cagcaggggg tgacggtgga cagcatcggg    960

atgctgcccc gcttcatccc cgagaaccag cgcaccgtcg ccgtatacag cttgaagatc   1020

gccgggtggc acgggcccaa ggccccatac acgagcaccc tgctgccccc ggagctgtcc   1080

gagaccccca acgccacgca gccagaactc gccccggaag accccgagga ttcggccctc   1140

ttggaggacc ccgtggggac ggtggtgccg caaatcccac caaactggca cataccgtcg   1200

atccaggacg ccgcgacgcc ttaccatccc ccggccaccc cgaacaacat gggcctgatc   1260

gccggcgcgg tgggcggcag tctcctggta gccctggtca tttgcggaat tgtgtactgg   1320

atgcgccgcc gcactcaaaa agccccaaag cgcatacgcc tcccccacat ccgggaagac   1380

gaccagccgt cctcgcacca gcccttgttt tactag                             1416


<210>  44
<211>  471
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL13-gD V37S amino acid

<400>  44

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Gln Phe Asn Gly Thr Gly Val Arg Arg Ser Tyr His Ile Gln Ala 
    130                 135                 140                 


Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr 
145                 150                 155                 160 


Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Asn Ala Pro 
                165                 170                 175     


Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp Val Arg Lys 
            180                 185                 190         


Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly Gly Asn Cys 
        195                 200                 205             


Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys 
    210                 215                 220                 


Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr 
225                 230                 235                 240 


Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met His 
                245                 250                 255     


Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile 
            260                 265                 270         


Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His Arg Ala Lys 
        275                 280                 285             


Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys 
    290                 295                 300                 


Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly 
305                 310                 315                 320 


Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr 
                325                 330                 335     


Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser 
            340                 345                 350         


Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro 
        355                 360                 365             


Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro 
    370                 375                 380                 


Val Gly Thr Val Val Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser 
385                 390                 395                 400 


Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn 
                405                 410                 415     


Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Val Ala Leu 
            420                 425                 430         


Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala 
        435                 440                 445             


Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser 
    450                 455                 460                 


Ser His Gln Pro Leu Phe Tyr 
465                 470     


<210>  45
<211>  773
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ATF-uPA-gD

<400>  45
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagatggc cgaccccaat    120

cgctttcgcg gcaaagacct tccggtcctc gagagcaatg aacttcatca agttccatcc    180

aactgtgact gtctaaatgg aggaacatgt gtgtccaaca agtacttctc caacattcac    240

tggtgcaact gcccaaagaa attcggaggg cagcactgtg aaatagataa gtcaaaaacc    300

tgctatgagg ggaatggtca cttttaccga ggaaaggcca gcactgacac catgggccgg    360

ccctgcctgc cctggaactc tgccactgtc cttcagcaaa cgtaccatgc ccacagatct    420

gatgctcttc agctgggcct ggggaaacat aattactgca ggaacccaga caaccggagg    480

cgaccctggt gctatgtgca ggtgggccta aagccgcttg tccaagagtg catggtgcat    540

gactgcgcag atggaaaagg taccctggac cggctgaccg accctccggg ggtccggcgc    600

gtgtaccaca tccaggcggg cctaccggac ccgttccagc cccccagcct cccgatcacg    660

gtttactacg ccgtgttgga gcgcgcctgc cgcagcgtgc tcctaaacgc accgtcggag    720

gccccccaga ttgtccgcgg ggcctccgaa gacgtccgga aacaacccta caa           773


<210>  46
<211>  440
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BD-uPA-gD

<400>  46
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagatggc cgaccccaat    120

cgctttcgcg gcaaagacct tccggtcctc gagctaaatg gaggaacatg tgtgtccaac    180

aagtacttct ccaacattca ctggtgcaac tgcccaaaga aattcggtac cctggaccgg    240

ctgaccgacc ctccgggggt ccggcgcgtg taccacatcc aggcgggcct accggacccg    300

ttccagcccc ccagcctccc gatcacggtt tactacgccg tgttggagcg cgcctgccgc    360

agcgtgctcc taaacgcacc gtcggaggcc ccccagattg tccgcggggc ctccgaagac    420

gtccggaaac aaccctacaa                                                440


<210>  47
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ATF-uPA-XhoI

<400>  47
ccgctcgaag caatgaactt catcaagttc catc                                 34


<210>  48
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ATF-uPA-KpnI

<400>  48
ggggtacctt ttccatctgc gcagtcatgc acc                                  33


<210>  49
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer for ATF-uPA-gD or BD-uPA-gD

<400>  49
cggaattcga tggggggggc tgccgccag                                       29


<210>  50
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer for ATF-uPA-gD or BD-uPA-gD

<400>  50
aactgcagct agtaaaacaa gggctggtgc g                                    31


<210>  51
<211>  2333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  uPA polynucleotide

<400>  51
cccgggccag ggtccacctg tccccgcagc gccggctcgc gccctcctgc cgcagccacc     60

gagccgccgt ctagcgcccc gacctcgcca ccatgagagc cctgctggcg cgcctgcttc    120

tctgcgtcct ggtcgtgagc gactccaaag gcagcaatga acttcatcaa gttccatcga    180

actgtgactg tctaaatgga ggaacatgtg tgtccaacaa gtacttctcc aacattcact    240

ggtgcaactg cccaaagaaa ttcggagggc agcactgtga aatagataag tcaaaaacct    300

gctatgaggg gaatggtcac ttttaccgag gaaaggccag cactgacacc atgggccggc    360

cctgcctgcc ctggaactct gccactgtcc ttcagcaaac gtaccatgcc cacagatctg    420

atgctcttca gctgggcctg gggaaacata attactgcag gaacccagac aaccggaggc    480

gaccctggtg ctatgtgcag gtgggcctaa agccgcttgt ccaagagtgc atggtgcatg    540

actgcgcaga tggaaaaaag ccctcctctc ctccagaaga attaaaattt cagtgtggcc    600

aaaagactct gaggccccgc tttaagatta ttgggggaga attcaccacc atcgagaacc    660

agccctggtt tgcggccatc tacaggaggc accggggggg ctctgtcacc tacgtgtgtg    720

gaggcagcct catcagccct tgctgggtga tcagcgccac acactgcttc attgattacc    780

caaagaagga ggactacatc gtctacctgg gtcgctcaag gcttaactcc aacacgcaag    840

gggagatgaa gtttgaggtg gaaaacctca tcctacacaa ggactacagc gctgacacgc    900

ttgctcacca caacgacatt gccttgctga agatccgttc caaggagggc aggtgtgcgc    960

agccatcccg gactatacag accatctgcc tgccctcgat gtataacgat ccccagtttg   1020

gcacaagctg tgagatcact ggctttggaa aagagaattc taccgactat ctctatccgg   1080

agcagctgaa aatgactgtt gtgaagctga tttcccaccg ggagtgtcag cagccccact   1140

actacggctc tgaagtcacc accaaaatgc tgtgtgctgc tgacccacag tggaaaacag   1200

attcctgcca gggagactca gggggacccc tcgtctgttc cctccaaggc cgcatgactt   1260

tgactggaat tgtgagctgg ggccgtggat gtgccctgaa ggacaagcca ggcgtctaca   1320

cgagagtctc acacttctta ccctggatcc gcagtcacac caaggaagag aatggcctgg   1380

ccctctgagg gtccccaggg aggaaacggg caccacccgc tttcttgctg gttgtcattt   1440

ttgcagtaga gtcatctcca tcagctgtaa gaagagactg ggaagatagg ctctgcacag   1500

atggatttgc ctgtgccacc caccagggtg aacgacaata gctttaccct caggcatagg   1560

cctgggtgct ggctgcccag acccctctgg ccaggatgga ggggtggtcc tgactcaaca   1620

tgttactgac cagcaacttg tctttttctg gactgaagcc tgcaggagtt aaaaagggca   1680

gggcatctcc tgtgcatggg tgaagggaga gccagctccc ccgacggtgg gcatttgtga   1740

ggcccatggt tgagaaatga ataatttccc aattaggaag tgtaacagct gaggtctctt   1800

gagggagctt agccaatgtg ggagcagcgg tttggggagc agagacacta acgacttcag   1860

ggcagggctc tgatattcca tgaatgtatc aggaaatata tatgtgtgtg tatgtttgca   1920

cacttgtgtg tgggctgtga gtgtaagtgt gagtaagagc tggtgtctga ttgttaagtc   1980

taaatatttc cttaaactgt gtggactgtg atgccacaca gagtggtctt tctggagagg   2040

ttataggtca ctcctggggc ctcttgggtc ccccacgtga cagtgcctgg gaatgtatta   2100

ttctgcagca tgacctgtga ccagcactgt ctcagtttca ctttcacata gatgtccctt   2160

tcttggccag ttatcccttc cttttagcct agttcatcca atcctcactg ggtggggtga   2220

ggaccactcc ttacactgaa tatttatatt tcactatttt tatttatatt tttgtaattt   2280

taaataaaag tgatcaataa aatgtgattt ttctgatgaa aaaaaaaaaa aaa          2333


<210>  52
<211>  431
<212>  PRT
<213>  Artificial sequence

<220>
<223>  uPA amino acid

<400>  52

Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210>  53
<211>  1602
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ATF-uPA-gD polynucleotide

<400>  53
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagatggc cgaccccaat    120

cgctttcgcg gcaaagacct tccggtcctc gagagcaatg aacttcatca agttccatcc    180

aactgtgact gtctaaatgg aggaacatgt gtgtccaaca agtacttctc caacattcac    240

tggtgcaact gcccaaagaa attcggaggg cagcactgtg aaatagataa gtcaaaaacc    300

tgctatgagg ggaatggtca cttttaccga ggaaaggcca gcactgacac catgggccgg    360

ccctgcctgc cctggaactc tgccactgtc cttcagcaaa cgtaccatgc ccacagatct    420

gatgctcttc agctgggcct ggggaaacat aattactgca ggaacccaga caaccggagg    480

cgaccctggt gctatgtgca ggtgggccta aagccgcttg tccaagagtg catggtgcat    540

gactgcgcag atggaaaagg taccctggac cggctgaccg accctccggg ggtccggcgc    600

gtgtaccaca tccaggcggg cctaccggac ccgttccagc cccccagcct cccgatcacg    660

gtttactacg ccgtgttgga gcgcgcctgc cgcagcgtgc tcctaaacgc accgtcggag    720

gccccccaga ttgtccgcgg ggcctccgaa gacgtccgga aacaacccta caacctgacc    780

atcgcttggt ttcggatggg aggcaactgt gctatcccca tcacggtcat ggagtacacc    840

gaatgctcct acaacaagtc tctgggggcc tgtcccatcc gaacgcagcc ccgctggaac    900

tactatgaca gcttcagcgc cgtcagcgag gataacctgg ggttcctgat gcacgccccc    960

gcgtttgaga ccgccggcac gtacctgcgg ctcgtgaaga taaacgactg gacggagatt   1020

acacagttta tcctggagca ccgagccaag ggctcctgta agtacgccct tccgctgcgc   1080

atccccccgt cagcctgcct ctccccccag gcctaccagc agggggtgac ggtggacagc   1140

atcgggatgc tgccccgctt catccccgag aaccagcgca ccgtcgccgt atacagcttg   1200

aagatcgccg ggtggcacgg gcccaaggcc ccatacacga gcaccctgct gcccccggag   1260

ctgtccgaga cccccaacgc cacgcagcca gaactcgccc cggaagaccc cgaggattcg   1320

gccctcttgg aggaccccgt ggggacggtg gtgccgcaaa tcccaccaaa ctggcacata   1380

ccgtcgatcc aggacgccgc gacgccttac catcccccgg ccaccccgaa caacatgggc   1440

ctgatcgccg gcgcggtggg cggcagtctc ctggtagccc tggtcatttg cggaattgtg   1500

tactggatgc gccgccgcac tcaaaaagcc ccaaagcgca tacgcctccc ccacatccgg   1560

gaagacgacc agccgtcctc gcaccagccc ttgttttact ag                      1602


<210>  54
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ATF-uPA-gD amino acid

<400>  54

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Glu Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
    50                  55                  60                  


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
65                  70                  75                  80  


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
                85                  90                  95      


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
            100                 105                 110         


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
        115                 120                 125             


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
    130                 135                 140                 


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
145                 150                 155                 160 


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
                165                 170                 175     


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Gly Thr Leu Asp Gln 
            180                 185                 190         


Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His Ile Gln Ala Gly 
        195                 200                 205             


Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr Tyr 
    210                 215                 220                 


Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Asn Ala Pro Ser 
225                 230                 235                 240 


Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp Val Arg Lys Gln 
                245                 250                 255     


Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly Gly Asn Cys Ala 
            260                 265                 270         


Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys Ser 
        275                 280                 285             


Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr Asp 
    290                 295                 300                 


Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala 
305                 310                 315                 320 


Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn 
                325                 330                 335     


Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His Arg Ala Lys Gly 
            340                 345                 350         


Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys Leu 
        355                 360                 365             


Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met 
    370                 375                 380                 


Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr Ser 
385                 390                 395                 400 


Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser Thr 
                405                 410                 415     


Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro Glu 
            420                 425                 430         


Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Val 
        435                 440                 445             


Gly Thr Val Val Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile 
    450                 455                 460                 


Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn Met 
465                 470                 475                 480 


Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Val Ala Leu Val 
                485                 490                 495     


Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala Pro 
            500                 505                 510         


Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser Ser 
        515                 520                 525             


His Gln Pro Leu Phe Tyr 
    530                 


<210>  55
<211>  1269
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BD-uPA-gD polynucleotide

<400>  55
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc     60

catggggtcc gcggcaaata tgccttggcg gatgcctctc tcaagatggc cgaccccaat    120

cgctttcgcg gcaaagacct tccggtcctc gagctaaatg gaggaacatg tgtgtccaac    180

aagtacttct ccaacattca ctggtgcaac tgcccaaaga aattcggtac cctggaccgg    240

ctgaccgacc ctccgggggt ccggcgcgtg taccacatcc aggcgggcct accggacccg    300

ttccagcccc ccagcctccc gatcacggtt tactacgccg tgttggagcg cgcctgccgc    360

agcgtgctcc taaacgcacc gtcggaggcc ccccagattg tccgcggggc ctccgaagac    420

gtccggaaac aaccctacaa cctgaccatc gcttggtttc ggatgggagg caactgtgct    480

atccccatca cggtcatgga gtacaccgaa tgctcctaca acaagtctct gggggcctgt    540

cccatccgaa cgcagccccg ctggaactac tatgacagct tcagcgccgt cagcgaggat    600

aacctggggt tcctgatgca cgcccccgcg tttgagaccg ccggcacgta cctgcggctc    660

gtgaagataa acgactggac ggagattaca cagtttatcc tggagcaccg agccaagggc    720

tcctgtaagt acgcccttcc gctgcgcatc cccccgtcag cctgcctctc cccccaggcc    780

taccagcagg gggtgacggt ggacagcatc gggatgctgc cccgcttcat ccccgagaac    840

cagcgcaccg tcgccgtata cagcttgaag atcgccgggt ggcacgggcc caaggcccca    900

tacacgagca ccctgctgcc cccggagctg tccgagaccc ccaacgccac gcagccagaa    960

ctcgccccgg aagaccccga ggattcggcc ctcttggagg accccgtggg gacggtggtg   1020

ccgcaaatcc caccaaactg gcacataccg tcgatccagg acgccgcgac gccttaccat   1080

cccccggcca ccccgaacaa catgggcctg atcgccggcg cggtgggcgg cagtctcctg   1140

gtagccctgg tcatttgcgg aattgtgtac tggatgcgcc gccgcactca aaaagcccca   1200

aagcgcatac gcctccccca catccgggaa gacgaccagc cgtcctcgca ccagcccttg   1260

ttttactag                                                           1269


<210>  56
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BD-uPA-gD amino acid

<400>  56

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Glu Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser 
    50                  55                  60                  


Asn Ile His Trp Cys Asn Cys Pro Lys Lys Phe Gly Thr Leu Asp Gln 
65                  70                  75                  80  


Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His Ile Gln Ala Gly 
                85                  90                  95      


Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr Tyr 
            100                 105                 110         


Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Asn Ala Pro Ser 
        115                 120                 125             


Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp Val Arg Lys Gln 
    130                 135                 140                 


Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly Gly Asn Cys Ala 
145                 150                 155                 160 


Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys Ser 
                165                 170                 175     


Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr Asp 
            180                 185                 190         


Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala 
        195                 200                 205             


Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn 
    210                 215                 220                 


Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His Arg Ala Lys Gly 
225                 230                 235                 240 


Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys Leu 
                245                 250                 255     


Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met 
            260                 265                 270         


Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr Ser 
        275                 280                 285             


Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser Thr 
    290                 295                 300                 


Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro Glu 
305                 310                 315                 320 


Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Val 
                325                 330                 335     


Gly Thr Val Val Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile 
            340                 345                 350         


Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn Met 
        355                 360                 365             


Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Val Ala Leu Val 
    370                 375                 380                 


Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala Pro 
385                 390                 395                 400 


Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser Ser 
                405                 410                 415     


His Gln Pro Leu Phe Tyr 
            420         


<210>  57
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human uPAR reverse

<400>  57
ggcagtcatt agcagggtga tggtg                                           25


<210>  58
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hamster uPAR reverse

<400>  58
gttgccctcg cagctgtaac actgg                                           25


<210>  59
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  uPAR-start forward

<400>  59
atgggtcacc cgccgctgct gccgc                                           25


<210>  60
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R5321 (pGG5414) forward primer

<400>  60
cggaattcat ggggggggct gccgccag                                        28


<210>  61
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R5322 (pGG5415) forward primer

<400>  61
cggaattcat ggcgcttttg ttgaccacgg                                      30


<210>  62
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R5323 (pGG5416) forward primer

<400>  62
cggaattcat gagagccctg ctggcgcgcc                                      30


<210>  63
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EcoRI-PstI fragment reverse primer

<400>  63
aactgcagct aggcgtagta aaccgtgatc ggg                                  33


<210>  64
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gD-A forward primer

<400>  64
cggaattcat gctgccccgc ttcatccccg ag                                   32


<210>  65
<211>  68
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gD-A reverse primer

<400>  65
aactgcagtt acaggtcctc ctctgagatc agcttctgca ttgatgcgtt gttcggggtg     60

gccggggg                                                              68


<210>  66
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  uPA ATF insertion forward primer

<400>  66
cggaattcat gagagccctg ctggcgcgcc                                      30


<210>  67
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  uPA ATF insertion reverse primer

<400>  67
aactgcagct attttccatc tgcgcagtca tgc                                  33


<210>  68
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  68
ctcttttgtc tcgagcgttc cggtatgggg                                      30


<210>  69
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  69
gtcaggtctg cgggctcgag atgggacctt                                      30


<210>  70
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  70
aactgcagaa ttcatgaaat atgccttggt ggatgcctct                           40


<210>  71
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  71
gaagatctag attacaggtc ctcctctgag atcagcttct gcattgatgc aggcgtcgcg     60

gcgtcctgga tcgac                                                      75


<210>  72
<211>  394
<212>  PRT
<213>  Herpes simplex virus 1

<400>  1

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp 
            100                 105                 110         


Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly 
        115                 120                 125             


Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr 
                325                 330                 335     


Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu 
            340                 345                 350         


Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr 
        355                 360                 365             


Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp 
    370                 375                 380                 


Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
385                 390                 


<210>  73
<211>  393
<212>  PRT
<213>  Herpes simplex virus 2

<400>  2

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ser Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 
            340                 345                 350         


Ala Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gln 
        355                 360                 365             


Met Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 
    370                 375                 380                 


Pro Pro Ser His Gln Pro Leu Phe Tyr 
385                 390             


<210>  74
<211>  395
<212>  PRT
<213>  Simian virus B

<400>  3

Met Gly Ser Gly Ile Ala Ala Val Leu Leu Ser Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Arg Val Pro Ala Gly Glu Gly Glu Tyr Val Pro Val Glu Arg Ser 
            20                  25                  30          


Leu Thr Arg Val Asn Pro Gly Arg Phe Arg Gly Ala His Leu Pro Pro 
        35                  40                  45              


Leu Glu Gln Lys Thr Asp Pro Pro Asp Val Arg Arg Val Tyr His Val 
    50                  55                  60                  


Gln Pro Phe Val Glu Asn Pro Phe Gln Thr Pro Ser Val Pro Val Ala 
65                  70                  75                  80  


Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Trp 
                85                  90                  95      


Ala Pro Thr Glu Ala Val Gln Val Val Arg Gly Ala Pro Glu Ala Thr 
            100                 105                 110         


Arg Ser Asp Ala Arg Tyr Asn Leu Thr Val Ala Trp Tyr Arg Thr Ser 
        115                 120                 125             


Asp Asp Cys Ala Ile Pro Ile Leu Val Met Glu Tyr Ala Glu Cys Gln 
    130                 135                 140                 


Tyr Asp Lys Pro Leu Gly Ala Cys Pro Val Arg Asn Leu Pro Arg Trp 
145                 150                 155                 160 


Ser Phe Tyr Asp Ser Phe Ser Ala Thr Gly Asp Asp Asp Leu Gly Leu 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Val Arg Leu 
            180                 185                 190         


Val Lys Val Asn Gly Trp Val Glu Val Thr Gln Phe Ile Phe Glu His 
        195                 200                 205             


Arg Gly Lys Gly Pro Cys Arg Tyr Thr Leu Pro Leu Arg Ile Leu Pro 
    210                 215                 220                 


Ala Ala Cys Leu Arg Ala Pro Val Phe Glu Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ala Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Ile Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Gln Ala Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Phe Thr Ser Thr Leu Leu Pro Pro Glu Val Val Glu Thr Ala Asn Val 
        275                 280                 285             


Thr Arg Pro Glu Leu Ala Pro Glu Glu Arg Gly Thr Ser Arg Thr Pro 
    290                 295                 300                 


Gly Asp Glu Pro Ala Pro Ala Val Ala Ala Gln Leu Pro Pro Asn Trp 
305                 310                 315                 320 


His Val Pro Glu Ala Ser Asp Val Thr Ile Gln Gly Pro Ala Pro Ala 
                325                 330                 335     


Pro Ser Gly His Thr Gly Ala Val Val Gly Ala Leu Ala Gly Ala Gly 
            340                 345                 350         


Leu Ala Ala Gly Val Val Val Leu Ala Val Tyr Leu Val Arg Arg Arg 
        355                 360                 365             


Gly Arg Ala Ala Gly Lys His Val Arg Leu Pro Glu Leu Leu Glu Glu 
    370                 375                 380                 


Ala His Gly Pro Ala Arg Arg Gly Ala Pro Tyr 
385                 390                 395 


