                         SEQUENCE LISTING

<110>  Novavax, Inc.
 
<120>  Chimeric Newcastle Disease Virus VLPs

<130>  NOVV-013/01WO

<150>  US 60/902,337
<151>  2007-02-21

<160>  10    

<170>  PatentIn version 3.4

<210>  1
<211>  364
<212>  PRT
<213>  Newcastle disease virus

<400>  1

Met Asp Ser Ser Arg Thr Ile Gly Leu Tyr Phe Asp Ser Ala Leu Pro 
1               5                   10                  15      


Ser Ser Asn Leu Leu Ala Phe Pro Ile Val Leu Arg Asp Val Gly Asp 
            20                  25                  30          


Gly Lys Lys Gln Ile Thr Pro Gln Tyr Arg Ile Arg Arg Leu Asp Ser 
        35                  40                  45              


Trp Thr Asp Ser Lys Glu Asp Ser Val Phe Ile Thr Thr Tyr Gly Phe 
    50                  55                  60                  


Ile Phe Gln Val Gly Asn Glu Glu Val Thr Val Gly Met Ile Asn Asp 
65                  70                  75                  80  


Asn Pro Lys Arg Glu Leu Leu Ser Ala Ala Met Leu Cys Leu Gly Ser 
                85                  90                  95      


Val Pro Asn Val Gly Asp Pro Val Glu Leu Ala Arg Ala Cys Leu Thr 
            100                 105                 110         


Met Val Val Thr Cys Lys Lys Ser Ala Thr Asn Thr Glu Arg Met Val 
        115                 120                 125             


Phe Ser Val Val Gln Ala Pro Arg Val Leu Gln Ser Cys Arg Val Val 
    130                 135                 140                 


Ala Asp Lys Tyr Ser Ser Val Asn Ala Val Lys His Val Lys Ala Pro 
145                 150                 155                 160 


Glu Lys Ile Pro Gly Ser Glu Thr Leu Glu Tyr Lys Val Asn Phe Val 
                165                 170                 175     


Ser Leu Thr Val Val Pro Lys Lys Asp Val Tyr Lys Ile Pro Thr Ala 
            180                 185                 190         


Val Leu Lys Val Ser Gly Ser Ser Leu Tyr Asn Leu Ala Leu Asn Val 
        195                 200                 205             


Thr Ile Asp Val Glu Val Asp Pro Lys Ser Pro Leu Val Lys Ser Leu 
    210                 215                 220                 


Ser Arg Ser Asp Ser Gly Tyr Tyr Ala Asn Leu Phe Leu His Ile Gly 
225                 230                 235                 240 


Leu Met Ser Thr Val Asp Lys Arg Gly Lys Lys Val Thr Phe Asp Gln 
                245                 250                 255     


Leu Glu Arg Lys Ile Arg Arg Leu Asp Leu Ser Val Gly Leu Ser Asp 
            260                 265                 270         


Val Leu Gly Pro Ser Val Leu Val Lys Ala Arg Gly Ala Arg Thr Arg 
        275                 280                 285             


Leu Leu Ala Pro Phe Phe Ser Asn Ser Gly Thr Ala Cys Tyr Pro Ile 
    290                 295                 300                 


Ala Asn Ala Ser Pro Gln Val Ala Lys Ile Leu Trp Ser Gln Thr Ala 
305                 310                 315                 320 


Cys Leu Arg Ser Val Lys Ile Ile Ile Gln Ala Gly Thr Gln Arg Ala 
                325                 330                 335     


Val Ala Val Thr Ala Asp His Glu Val Thr Ser Thr Lys Ile Glu Lys 
            340                 345                 350         


Arg His Thr Ile Ala Lys Tyr Asn Pro Phe Lys Lys 
        355                 360                 


<210>  2
<211>  553
<212>  PRT
<213>  Newcastle disease virus

<400>  2

Met Gly Pro Arg Ser Ser Thr Arg Ile Pro Val Pro Leu Met Leu Thr 
1               5                   10                  15      


Ile Arg Ile Thr Leu Ala Leu Ser Tyr Val Arg Leu Thr Ser Ser Leu 
            20                  25                  30          


Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Met Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Glu Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Arg 
            100                 105                 110         


Arg Gln Arg Arg Phe Ile Gly Ala Ile Ile Gly Ser Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ser Ala Leu Ile Gln Ala 
    130                 135                 140                 


Asn Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Gly Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Asn 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Thr Gln Leu Thr Val Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Val Asp Tyr Leu Leu Thr Lys Leu Gly Val Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Phe Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Lys Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Ala Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Leu Lys Gly Ser Val Val Ala Asn Cys Gln Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Ala Asp Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys His Ser Cys Asn Val Val Ser Leu Asp Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Leu Asp Ser Gln Val Leu Val Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn His Ser Ile Ser Asn Ala Leu Asp Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Arg Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Val Ile Ser Leu 
            500                 505                 510         


Val Leu Gly Met Leu Ser Leu Val Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Arg Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  3
<211>  571
<212>  PRT
<213>  Newcastle disease virus

<400>  3

Met Asp Ser Ala Val Ser Gln Val Ala Leu Glu Asn Asp Arg Arg Glu 
1               5                   10                  15      


Ala Lys Asp Thr Trp Arg Leu Val Phe Arg Ile Ala Ala Leu Leu Leu 
            20                  25                  30          


Met Val Ile Thr Leu Ala Val Ser Ala Val Ala Leu Ala Tyr Ser Met 
        35                  40                  45              


Glu Ala Ser Thr Pro Gly Asp Leu Val Ser Ile Pro Thr Ala Ile Tyr 
    50                  55                  60                  


Arg Ala Glu Glu Arg Ile Thr Ser Ala Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  


Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Ser Ile Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Gly Ala Thr Asn Asn Ser Gly Cys Gly Ala Pro Val His 
        115                 120                 125             


Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 


Thr Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Arg Asp His Ser His Ser His Gln Tyr Leu Ala Leu 
        195                 200                 205             


Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Ala Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Ile Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Lys Ser Val Ile Pro Thr Ser Met Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Thr Thr Leu Phe Arg Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Ile Asn Asn Arg Val Trp Phe Pro Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Ser Ser Pro Ser Asp Thr Ala Gln Glu Gly Arg Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         


Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             


Val Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 


Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Ala Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Val Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Asn 
            420                 425                 430         


Asn Lys Thr Ala Thr Leu His Asn Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Val Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Val Phe His Arg 
465                 470                 475                 480 


Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Asp Lys Gln 
                485                 490                 495     


Ala Arg Leu Asn Pro Val Ser Ala Val Phe Asp Asn Ile Ser Arg Ser 
            500                 505                 510         


Arg Ile Thr Arg Val Ser Ser Ser Ser Thr Arg Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Lys Asp Gly Gly Val 
                565                 570     


<210>  4
<211>  489
<212>  PRT
<213>  Newcastle disease virus

<400>  4

Met Ser Ser Val Phe Asp Glu Tyr Glu Gln Leu Leu Ala Ala Gln Thr 
1               5                   10                  15      


Arg Pro Asn Gly Ala His Gly Gly Gly Glu Lys Gly Ser Thr Leu Lys 
            20                  25                  30          


Val Glu Val Pro Val Phe Thr Leu Asn Ser Asp Asp Pro Glu Asp Arg 
        35                  40                  45              


Trp Asn Phe Ala Val Phe Cys Leu Arg Ile Ala Val Ser Glu Asp Ala 
    50                  55                  60                  


Asn Lys Pro Leu Arg Gln Gly Ala Leu Ile Ser Leu Leu Cys Ser His 
65                  70                  75                  80  


Ser Gln Val Met Arg Asn His Val Ala Leu Ala Gly Lys Gln Asn Glu 
                85                  90                  95      


Ala Thr Leu Ala Val Leu Glu Ile Asp Gly Phe Thr Asn Ser Val Pro 
            100                 105                 110         


Gln Phe Asn Asn Arg Ser Gly Val Ser Glu Glu Arg Ala Gln Arg Phe 
        115                 120                 125             


Leu Met Ile Ala Gly Ser Leu Pro Arg Ala Cys Ser Asn Gly Thr Pro 
    130                 135                 140                 


Phe Thr Thr Ala Gly Val Glu Asp Asp Ala Pro Glu Asp Ile Thr Asp 
145                 150                 155                 160 


Thr Leu Glu Arg Ile Ile Ser Ile Gln Ala Gln Val Trp Val Thr Val 
                165                 170                 175     


Ala Lys Ala Met Thr Ala Tyr Glu Thr Ala Asp Glu Ser Glu Thr Arg 
            180                 185                 190         


Arg Ile Asn Lys Tyr Met Gln Gln Gly Arg Val Gln Lys Lys Tyr Ile 
        195                 200                 205             


Leu His Pro Val Cys Arg Ser Ala Ile Gln Leu Thr Ile Arg Gln Ser 
    210                 215                 220                 


Leu Ala Val Arg Ile Phe Leu Val Ser Glu Leu Lys Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ala Gly Gly Ser Ser Thr Tyr Tyr Ser Leu Val Gly Asp Ile Asp 
                245                 250                 255     


Ser Tyr Ile Arg Asn Thr Gly Leu Thr Ala Phe Phe Leu Thr Leu Lys 
            260                 265                 270         


Tyr Gly Ile Asn Thr Lys Thr Ser Ala Leu Ala Leu Ser Ser Leu Ala 
        275                 280                 285             


Gly Asp Ile Gln Lys Met Lys Gln Leu Met Arg Leu Tyr Arg Met Lys 
    290                 295                 300                 


Gly Asp Asn Ala Pro Tyr Met Thr Leu Leu Gly Asp Ser Asp Gln Met 
305                 310                 315                 320 


Ser Phe Ala Pro Ala Glu Tyr Ala Gln Leu Tyr Ser Phe Ala Met Gly 
                325                 330                 335     


Met Ala Ser Val Leu Asp Lys Gly Thr Gly Lys Tyr Gln Phe Ala Arg 
            340                 345                 350         


Asp Phe Met Ser Thr Ser Phe Trp Arg Leu Gly Val Glu Tyr Ala Arg 
        355                 360                 365             


Ala Gln Gly Ser Ser Ile Asn Glu Asp Met Ala Ala Glu Leu Lys Leu 
    370                 375                 380                 


Thr Pro Ala Ala Arg Arg Gly Leu Ala Ala Ala Ala Gln Arg Ala Ser 
385                 390                 395                 400 


Glu Glu Thr Gly Ser Met Asp Ile Pro Thr Gln Gln Ala Gly Val Leu 
                405                 410                 415     


Thr Gly Leu Ser Asp Gly Gly Pro Gln Ala Pro Gln Gly Gly Leu Asn 
            420                 425                 430         


Arg Ser Gln Gly Gln Pro Asp Ala Gly Asp Gly Glu Thr Gln Phe Leu 
        435                 440                 445             


Asp Leu Met Arg Ala Val Ala Asn Ser Met Arg Glu Ala Pro Asn Ser 
    450                 455                 460                 


Val Gln Asn Thr Thr Gln Gln Glu Pro Pro Ser Thr Pro Gly Pro Ser 
465                 470                 475                 480 


Gln Asp Asn Asp Thr Asp Trp Gly Tyr 
                485                 


<210>  5
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized NDV M protein

<400>  5
atggactctt ctagaaccat cggtttgtac ttcgactctg ctttgccatc ttctaacttg     60

ttggctttcc caatcgtttt gagagacgtt ggtgacggta agaagcaaat caccccacaa    120

tacagaatca gaagattgga ctcttggacc gactctaagg aagactctgt tttcatcacc    180

acctacggtt tcatcttcca agttggtaac gaagaagtta ccgttggtat gatcaacgac    240

aacccaaaga gagaattgtt gtctgctgct atgttgtgtt tgggttctgt tccaaacgtt    300

ggtgacccag ttgaattggc tagagcttgt ttgaccatgg ttgttacctg taagaagtct    360

gctaccaaca ccgaaagaat ggttttctct gttgttcaag ctccaagagt tttgcaatct    420

tgtagagttg ttgctgacaa gtactcttct gttaacgctg ttaagcacgt taaggctcca    480

gaaaagatcc caggttctga aaccttggaa tacaaggtta acttcgtttc tttgaccgtt    540

gttccaaaga aggacgttta caagatccca accgctgttt tgaaggtttc tggttcttct    600

ttgtacaact tggctttgaa cgttaccatc gacgttgaag ttgacccaaa gtctccattg    660

gttaagtctt tgtctagatc tgactctggt tactacgcta acttgttctt gcacatcggt    720

ttgatgtcta ccgttgacaa gagaggtaag aaggttacct tcgaccaatt ggaaagaaag    780

atcagaagat tggacttgtc tgttggtttg tctgacgttt tgggtccatc tgttttggtt    840

aaggctagag gtgctagaac cagattgttg gctccattct tctctaactc tggtaccgct    900

tgttacccaa tcgctaacgc ttctccacaa gttgctaaga tcttgtggtc tcaaaccgct    960

tgtttgagat ctgttaagat catcatccaa gctggtaccc aaagagctgt tgctgttacc   1020

gctgaccacg aagttacctc taccaagatc gaaaagagac acaccatcgc taagtacaac   1080

ccattcaaga agtga                                                    1095


<210>  6
<211>  1662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized NDV F protein

<400>  6
atgggtccaa gatcttctac cagaatccca gttccattga tgttgaccat cagaatcacc     60

ttggctttgt cttacgttag attgacctct tctttggacg gtagaccatt ggctgctgct    120

ggtatcgttg ttaccggtga caaggctgtt aacatctaca cctcttctca aaccggttct    180

atcatcgtta agttgttgcc aaacatgcca aaggacaagg aagcttgtgc taaggctcca    240

ttggaagctt acaacagaac cttgaccacc ttgttgaccc cattgggtga ctctatcaga    300

agaatccaag aatctgttac cacctctggt ggtagaagac aaagaagatt catcggtgct    360

atcatcggtt ctgttgcttt gggtgttgct accgctgctc aaatcaccgc tgcttctgct    420

ttgatccaag ctaaccaaaa cgctgctaac atcttgagat tgaaggaatc tatcgctgct    480

accaacgaag ctgttcacga agttaccggt ggtttgtctc aattggctgt tgctgttggt    540

aagatgcaac aattcgttaa cgaccaattc aacaacaccg ctcaagaatt ggactgtatc    600

aagatcgctc aacaagttgg tgttgaattg aacttgtact tgaccgaatt gaccaccgtt    660

ttcggtccac aaatcacctc tccagctttg acccaattga ccgttcaagc tttgtacaac    720

ttggctggtg gtaacgttga ctacttgttg accaagttgg gtgttggtaa caaccaattg    780

tcttctttga tcggttctgg tttgatcacc ggtaacccaa tcttctacga ctctcaaacc    840

caattgttgg gtatccaagt taccttgcca tctgttggta acttgaacaa catgagagct    900

acctacttgg aaaccttgtc tgtttctacc accaagggtt tcgcttctgc tttggttcca    960

aaggttgtta cccaagttgg ttctgttatc gaagaattgg acacctctta ctgtatcgaa   1020

gctgacttgg acttgtactg taccagaatc gttaccttcc caatgtctcc aggtatctac   1080

tcttgtttgt ctggtaacac ctctgcttgt atgtactcta agaccgaagg tgctttgacc   1140

accccataca tgaccttgaa gggttctgtt gttgctaact gtcaaatgac cacctgtaga   1200

tgtgctgacc caccaggtat catctctcaa aactacggtg aagctgtttc tttgatcgac   1260

aagcactctt gtaacgttgt ttctttggac ggtatcacct tgagattgtc tggtgaattc   1320

gacgctacct accaaaagaa catctctatc ttggactctc aagttttggt taccggtaac   1380

ttggacatct ctaccgaatt gggtaacgtt aaccactcta tctctaacgc tttggacaag   1440

ttggaagaat ctaactctaa gttggacaag gttaacgtta gattgacctc tacctctgct   1500

ttgatcacct acatcgtttt gaccgttatc tctttggttt tgggtatgtt gtctttggtt   1560

ttggcttgtt acttgatgta caagcaaaag gctcaaagaa agaccttgtt gtggttgggt   1620

aacaacacct tggaccaaat gagagctacc accaagatgt ga                      1662


<210>  7
<211>  1716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized NDV HN protein

<400>  7
atggactctg ctgtttctca agttgctttg gaaaacgaca gaagagaagc taaggacacc     60

tggagattgg ttttcagaat cgctgctttg ttgttgatgg ttatcacctt ggctgtttct    120

gctgttgctt tggcttactc tatggaagct tctaccccag gtgacttggt ttctatccca    180

accgctatct acagagctga agaaagaatc acctctgctt tgggttctaa ccaagacgtt    240

gttgacagaa tctacaagca agttgctttg gaatctccat tggctttgtt gaacaccgaa    300

tctatcatca tgaacgctat cacctctttg tcttaccaaa tcaacggtgc taccaacaac    360

tctggttgtg gtgctccagt tcacgaccca gactacatcg gtggtatcgg taaggaattg    420

atcgttgacg acacctctga cgttacctct ttctacccat ctgctttcca agaacacttg    480

aacttcatcc cagctccaac caccggttct ggttgtacca gaatcccatc tttcgacatg    540

tctgctaccc actactgtta cacccacaac gttatcttgt ctggttgtag agaccactct    600

cactctcacc aatacttggc tttgggtgtt ttgagaacct ctgctaccgg tagagttttc    660

ttctctacct tgagatctat caacttggac gacgctcaaa acagaaagtc ttgttctgtt    720

tctgctaccc cattgggttg tgacatgttg tgttctaaga tcaccgaaac cgaagaagaa    780

gactacaagt ctgttatccc aacctctatg gttcacggta gattgggttt cgacggtcaa    840

taccacgaaa aggacttgga cgttaccacc ttgttcagag actgggttgc taactaccca    900

ggtgttggtg gtggttcttt catcaacaac agagtttggt tcccagttta cggtggtttg    960

aagccatctt ctccatctga caccgctcaa gaaggtagat acgttatcta caagagatac   1020

aacgacacct gtccagacga acaagactac caaatcagaa tggctaagtc ttcttacaag   1080

ccaggtagat tcggtggtaa gagagttcaa caagctatct tgtctatcaa ggtttctacc   1140

tctttgggtg aagacccagt tttgaccgtt ccaccaaaca ccgttgcttt gatgggtgct   1200

gaaggtagag ttttgaccgt tggtacctct cacttcttgt accaaagagg ttcttcttac   1260

ttctctccag ctttgttgta cccaatgacc gttaacaaca agaccgctac cttgcacaac   1320

ccatacacct tcaacgcttt caccagacca ggttctgttc catgtcaagc ttctgctaga   1380

tgtccaaact cttgtgttac cggtgtttac accgacccat acccattggt tttccacaga   1440

aaccacacct tgagaggtgt tttcggtacc atgttggacg acaagcaagc tagattgaac   1500

ccagtttctg ctgttttcga caacatctct agatctagaa tcaccagagt ttcttcttct   1560

tctaccagag ctgcttacac cacctctacc tgtttcaagg ttgttaagac caacaagacc   1620

tactgtttgt ctatcgctga aatctctaac accttgttcg gtgaattcag aatcgttcca   1680

ttgttggttg aaatcttgaa ggacggtggt gtttga                             1716


<210>  8
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized NDV NP protein

<400>  8
atgtcttctg ttttcgacga atacgaacaa ttgttggctg ctcaaaccag accaaacggt     60

gctcacggtg gtggtgaaaa gggttctacc ttgaaggttg aagttccagt tttcaccttg    120

aactctgacg acccagaaga cagatggaac ttcgctgttt tctgtttgag aatcgctgtt    180

tctgaagacg ctaacaagcc attgagacaa ggtgctttga tctctttgtt gtgttctcac    240

tctcaagtta tgagaaacca cgttgctttg gctggtaagc aaaacgaagc taccttggct    300

gttttggaaa tcgacggttt caccaactct gttccacaat tcaacaacag atctggtgtt    360

tctgaagaaa gagctcaaag attcttgatg atcgctggtt ctttgccaag agcttgttct    420

aacggtaccc cattcaccac cgctggtgtt gaagacgacg ctccagaaga catcaccgac    480

accttggaaa gaatcatctc tatccaagct caagtttggg ttaccgttgc taaggctatg    540

accgcttacg aaaccgctga cgaatctgaa accagaagaa tcaacaagta catgcaacaa    600

ggtagagttc aaaagaagta catcttgcac ccagtttgta gatctgctat ccaattgacc    660

atcagacaat ctttggctgt tagaatcttc ttggtttctg aattgaagag aggtagaaac    720

accgctggtg gttcttctac ctactactct ttggttggtg acatcgactc ttacatcaga    780

aacaccggtt tgaccgcttt cttcttgacc ttgaagtacg gtatcaacac caagacctct    840

gctttggctt tgtcttcttt ggctggtgac atccaaaaga tgaagcaatt gatgagattg    900

tacagaatga agggtgacaa cgctccatac atgaccttgt tgggtgactc tgaccaaatg    960

tctttcgctc cagctgaata cgctcaattg tactctttcg ctatgggtat ggcttctgtt   1020

ttggacaagg gtaccggtaa gtaccaattc gctagagact tcatgtctac ctctttctgg   1080

agattgggtg ttgaatacgc tagagctcaa ggttcttcta tcaacgaaga catggctgct   1140

gaattgaagt tgaccccagc tgctagaaga ggtttggctg ctgctgctca aagagcttct   1200

gaagaaaccg gttctatgga catcccaacc caacaagctg gtgttttgac cggtttgtct   1260

gacggtggtc cacaagctcc acaaggtggt ttgaacagat ctcaaggtca accagacgct   1320

ggtgacggtg aaacccaatt cttggacttg atgagagctg ttgctaactc tatgagagaa   1380

gctccaaact ctgttcaaaa caccacccaa caagaaccac catctacccc aggtccatct   1440

caagacaacg acaccgactg gggttactga                                    1470


<210>  9
<211>  566
<212>  PRT
<213>  Influenza virus

<400>  9

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val Leu His Pro Gly Thr Asp Ser Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Ile Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  10
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proposed chimeric Influenza HA-NDV F protein

<400>  10

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val Leu His Pro Gly Thr Asp Ser Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asp Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Ile Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Thr Tyr Ile Val Leu Thr Val Ile Ser Leu Val Leu Gly Met Leu 
    530                 535                 540                 


Ser Leu Val Leu Ala Cys Tyr Leu Met Tyr Lys Gln Lys Ala Gln Arg 
545                 550                 555                 560 


Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu Asp Gln Met Arg Ala 
                565                 570                 575     


Thr Thr Lys Met 
            580 


