
                                SEQUENCE LISTING

<110> Tanox, Inc.
      LAMHAMEDI-CHERRADI, Salah-Eddine
      YAO, Zhengbin
      SINGH, Sanjaya

<120> ANTAGONIST OX40 ANTIBODIES AND THEIR USE
  IN THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES
  

<130> 12279-205-228

<140> Unknown             
<141>             

<150> 60/903,693          
<151> 2007-02-27  

<160> 60

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1084
<212> DNA
<213> Homo sapiens

<400> 1
cgaggatgtg cgtgggggct cggcggctgg gccgcgggcc gtgtgcggct ctgctcctcc 60
tgggcctggg gctgagcacc gtgacggggc tccactgtgt cggggacacc taccccagca 120
acgaccggtg ctgccacgag tgcaggccag gcaacgggat ggtgagccgc tgcagccgct 180
cccagaacac ggtgtgccgt ccgtgcgggc cgggcttcta caacgacgtg gtcagctcca 240
agccgtgcaa gccctgcacg tggtgtaacc tcagaagtgg gagtgagcgg aagcagctgt 300
gcacggccac acaggacaca gtctgccgct gccgggcggg cacccagccc ctggacagct 360
acaagcctgg agttgactgt gccccctgcc ctccagggca cttctcccca ggcgacaacc 420
aggcctgcaa gccctggacc aactgcacct tggctgggaa gcacaccctg cagccggcca 480
gcaatagctc ggacgcaatc tgtgaggaca gggacccccc agccacgcag ccccaggaga 540
cccagggccc cccggccagg cccatcactg tccagcccac tgaagcctgg cccagaacct 600
cacagggacc ctccacccgg cccgtggagg tccccggggg ccgtgcggtt gccgccatcc 660
tgggcctggg cctggtgctg gggctgctgg gccccctggc catcctgctg gccctgtacc 720
tgctccggag ggaccagagg ctgccccccg atgcccacaa gccccctggg ggaggcagtt 780
tccggacccc catccaagag gagcaggccg acgcccactc caccctggcc aagatctgac 840
ctgggcccac caaggtggac gctgggcccc gccaggctgg agcccggagg gtctgctggg 900
cgagcagggc aggtgcaggc cgcctgcccc gccacgctcc tgggccaact ctgcaccgtt 960
ctaggtgccg atggctgcct ccggctctct gcttacgtat gccatgcata cctcctgccc 1020
cgcgggacca caataaaaac cttggcagac gggagtctcc gaccggcaaa aaaaaaaaaa 1080
aaaa                                                              1084

<210> 2
<211> 277
<212> PRT
<213> Homo sapiens

<400> 2
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu
 1               5                  10                  15      
Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val
            20                  25                  30          
Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro
        35                  40                  45              
Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys
    50                  55                  60                  
Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro
65                  70                  75                  80  
Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys
                85                  90                  95      
Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly
            100                 105                 110         
Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys
        115                 120                 125             
Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp
    130                 135                 140                 
Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn
145                 150                 155                 160 
Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro
                165                 170                 175     
Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr
            180                 185                 190         
Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu
        195                 200                 205             
Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val
    210                 215                 220                 
Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu
225                 230                 235                 240 
Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly
                245                 250                 255     
Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser
            260                 265                 270         
Thr Leu Ala Lys Ile
        275         


<210> 3
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> OLIGONUCLEOTIDE PRIMER FOR OX40

<400> 3
cccaagcttt accccagcaa cgaccggtgc tgc                              33

<210> 4
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> OLIGONUCLEOTIDE PRIMER FOR OX40

<400> 4
cgcctcgagg acctccacgg gccgggtgg                                   29

<210> 5
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> OLIGONUCLEOTIDE PRIMER FOR OX40

<400> 5
caccatgtgc gtgggggctc ggcggctggg                                  30

<210> 6
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> OLIGONUCLEOTIDE PRIMER FOR OX40

<400> 6
gatcttggcc agggtggagt gggcgtcggc c                                31

<210> 7
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF MURINE ANTI-OX40
      ANTIBODY B66

<400> 7
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Thr Val Asp Tyr Asp
            20                  25                  30          
Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 8
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF MURINE ANTI-OX40
      ANTIBODY A10

<400> 8
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Thr Thr Tyr Tyr Cys His Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 9
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10LC(TH)hu336

<400> 9
Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Thr Val Asp Tyr Asp
            20                  25                  30          
Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105                 110     


<210> 10
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> VARIABLE HEAVY CHAIN REGION OF MURINE ANTI-OX40
      ANTIBODY A10

<400> 10
Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile His Pro Lys Ser Gly Asn Ser Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Pro Glu Tyr Ser Asn Phe Trp Phe Ala Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala
        115                 120 


<210> 11
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> VARIABLE HEAVY CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10LC(TH)hu336

<400> 11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Glu Ile His Pro Lys Ser Gly Asn Ser Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Pro Glu Tyr Ser Asn Phe Trp Phe Ala Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L1 OF MURINE ANTI-OX40 ANTIBODY B66

<400> 12
Lys Ala Ser Gln Thr Val Asp Tyr Asp Gly Asp Ser Tyr Met His
 1               5                  10                  15  


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L2 OF ANTI-OX40 ANTIBODY A10 AND B66

<400> 13
Ala Ala Ser Asn Leu Glu Ser
 1               5          


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L3 OF ANTI-OX40 ANTIBODY B66

<400> 14
Gln Gln Ser Asn Glu Asp Pro Tyr Thr
 1               5                  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L1 OF ANTI-OX40 ANTIBODY A10

<400> 15
Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn
 1               5                  10                  15  


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L3 OF ANTI-OX40 ANTIBODY A10

<400> 16
His Gln Ser Asn Glu Asp Pro Trp Thr
 1               5                  


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1 OF ANTI-OX40 ANTIBODY A10 AND B66

<400> 17
Ser Tyr Trp Met His
 1               5  


<210> 18
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H2 OF ANTI-OX40 ANTIBODY A10 AND B66

<400> 18
Glu Ile His Pro Lys Ser Gly Asn Ser Asn Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H3 OF ANTI-OX40 ANTIBODY A10 AND B66

<400> 19
Gly Pro Glu Tyr Ser Asn Phe Trp Phe Ala Tyr
 1               5                  10      


<210> 20
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF MURINE ANTI-OX40
      ANTIBODY A10

<400> 20
gacattgtgc tgacccaatc tccaacttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac 120
caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct 180
gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatgc tacaacctat tactgtcacc agagtaatga ggatccgtgg 300
acgttcggtg gaggcaccaa gctggaaatc aaa                              333

<210> 21
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF MURINE ANTI-OX40
      ANTIBODY B66

<400> 21
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aactgttgat tatgatggtg acagttatat gcattggtac 120
caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct 180
gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtac 300
acgttcggag gggggaccaa gctggaaata aaa                              333

<210> 22
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10B & A10E

<400> 22
gacatcgtga tgacccagag cccagacagc ctggccgtga gcctgggcga gcgcgccacc 60
atcaactgca aggccagcca gagcgtggac tacgacggcg acagctacat gaactggtac 120
cagcagaagc caggccagcc accaaagctg ctgatctacg ccgccagcaa cctggagagc 180
ggcgtgccag accgcttcag cggcagcggc agcggcaccg acttcaccct gaccatcagc 240
agcctgcagg ccgaggacgt ggccgtgtac tactgccacc agagcaacga ggacccatgg 300
accttcggcc agggcaccaa ggtggagatc aag                              333

<210> 23
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10A & A10D

<400> 23
gacatcgtga tgacccagag cccagacagc ctggccgtga gcctgggcga gcgcgccacc 60
atcaactgca aggccagcca gagcgtggac tacgacggcg acagctacat gcactggtac 120
cagcagaagc caggccagcc accaaagctg ctgatctacg ccgccagcaa cctggagagc 180
ggcgtgccag accgcttcag cggcagcggc agcggcaccg acttcaccct gaccatcagc 240
agcctgcagg ccgaggacgt ggccgtgtac tactgccacc agagcaacga ggacccatgg 300
accttcggcc agggcaccaa ggtggagatc aag                              333

<210> 24
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE LIGHT CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10(TH)HU336F & A10C

<400> 24
gacatcgtga tgacccagag cccagacagc ctggccgtga gcctgggcga gcgcgccacc 60
atcaactgca aggccagcca gaccgtggac tacgacggcg acagctacat gcactggtac 120
cagcagaagc caggccagcc accaaagctg ctgatctacg ccgccagcaa cctggagagc 180
ggcgtgccag accgcttcag cggcagcggc agcggcaccg acttcaccct gaccatcagc 240
agcctgcagg ccgaggacgt ggccgtgtac tactgccacc agagcaacga ggacccatgg 300
accttcggcc agggcaccaa ggtggagatc aag                              333

<210> 25
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE HEAVY CHAIN REGION OF MURINE ANTI-OX40
      ANTIBODY A10

<400> 25
caggtccaac tgcagcagcc tgggtctgtg ctggtgaggc ctggagcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcacc agctactgga tgcattgggt gaagcagagg 120
cctggacaag gccttgagtg gattggagag attcatccta aaagtggtaa tagtaactac 180
aatgagaagt tcaagggcag ggccacactg actgtagaca catcctccag cacagcctac 240
gtggatctta gcagcctgac atctgaggac tctgcggtct attactgtgc aagaggtccg 300
gaatatagta atttttggtt tgcttattgg ggccaaggaa ctctggtcac tgtctctgca 360


<210> 26
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE HEAVY CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10(TH)HU336F & A10D &A10E

<400> 26
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc caggcgccag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gcgccaggcc 120
ccaggccagg gcctggagtg gatgggcgag atccacccaa agagcggcaa cagcaactac 180
aacgagaagt tcaagggccg cgtgaccatg acccgcgaca ccagcaccag caccgtgtac 240
atggagctga gcagcctgcg cagcgaggac accgccgtgt actactgcgc ccgcggccca 300
gagtacagca acttctggtt cgcctactgg ggccagggca ccctggtgac cgtgagcagc 360


<210> 27
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> VARIABLE HEAVY CHAIN REGION OF HUMANIZED ANTI-OX40
      ANTIBODY A10L70 & A10A-C

<400> 27
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc caggcgccag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gcgccaggcc 120
ccaggccagg gcctggagtg gatgggcgag atccacccaa agagcggcaa cagcaactac 180
aacgagaagt tcaagggccg cgtgaccctg acccgcgaca ccagcaccag caccgtgtac 240
atggagctga gcagcctgcg cagcgaggac accgccgtgt actactgcgc ccgcggccca 300
gagtacagca acttctggtt cgcctactgg ggccagggca ccctggtgac cgtgagcagc 360


<210> 28
<211> 111
<212> PRT
<213> Homo sapiens


<220> 
<221> VARIANT        
<222> 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 35, 36, 37, 38, 
54, 55, 56, 57, 58, 59, 93, 94, 95, 96, 97, 98, 99, 100, 101
<223> Xaa = Any Amino Acid

<220> 
<223> Human template Variable Light Chain IGKV4-1/IGKJ1

<400> 28
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Xaa Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105                 110     


<210> 29
<211> 120
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 99, 100, 101, 102, 103, 104,
105, 106, 107, 108, 109

<223> Xaa = Any Amino Acid

<220>
<223> Human Template Heavy Chain Region IGHV1-45/IGHJ4

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 30
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 36, 37, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 103, 104, 105,
106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117,
118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220>
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
        35                  40                  45              
Trp Met Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
65                  70                  75                  80  
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 31
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 103, 104, 105, 106, 107, 108, 109, 110, 111,
112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 31
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
        35                  40                  45              
Trp Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
65                  70                  75                  80  
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 32
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 102, 103, 104, 105, 106, 107, 108, 109, 110,
111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 32
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
        35                  40                  45              
Trp Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
65                  70                  75                  80  
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 33
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 101, 102, 103, 104, 105, 106, 107, 108, 109,
110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 33
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
        35                  40                  45              
Trp Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
65                  70                  75                  80  
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 34
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 36, 37, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 103, 104, 105,
106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117,
118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 34
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Ser Val Asp Thr Ser Lys
65                  70                  75                  80  
Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 35
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 103, 104, 105, 106, 107, 108, 109, 110, 111,
112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 35
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Ser Val Asp Thr Ser Lys
65                  70                  75                  80  
Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 36
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 102, 103, 104, 105, 106, 107, 108, 109, 110,
111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 36
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Ser Val Asp Thr Ser Lys
65                  70                  75                  80  
Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 37
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 101, 102, 103, 104, 105, 106, 107, 108, 109,
110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid


<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 37
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Val Thr Ile Ser Val Asp Thr Ser Lys
65                  70                  75                  80  
Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 38
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 36, 37, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 103, 104, 105,
106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117,
118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION


<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
65                  70                  75                  80  
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 39
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 103, 104, 105, 106, 107, 108, 109, 110, 111,
112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid


<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
65                  70                  75                  80  
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 40
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 102, 103, 104, 105, 106, 107, 108, 109, 110,
111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
65                  70                  75                  80  
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 41
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 101, 102, 103, 104, 105, 106, 107, 108, 109,
110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
65                  70                  75                  80  
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 42
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 36, 37, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 103, 104, 105,
106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117,
118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ser Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 43
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 103, 104, 105, 106, 107, 108, 109, 110, 111,
112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid


<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ser Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 44
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 102, 103, 104, 105, 106, 107, 108, 109, 110,
111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 45
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 31, 32, 33, 34, 35, 36, 37, 52, 53, 54, 55, 56, 57, 58, 59,
60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 103, 104, 105,
106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117,
118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 46
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 103, 104, 105, 106, 107, 108, 109, 110, 111,
112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 47
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 102, 103, 104, 105, 106, 107, 108, 109, 110,
111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid


<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 48
<211> 132
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
68, 69, 70, 101, 102, 103, 104, 105, 106, 107, 108, 109,
110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121
<223> Xaa = Any Amino Acid

<220> 
<223> HEAVY CHAIN FRAMEWORK REGION

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
65                  70                  75                  80  
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val
        115                 120                 125             
Thr Val Ser Ser
    130         


<210> 49
<211> 82
<212> PRT
<213> Artificial Sequence


<220>
<221> VARIANT        
<222> 24, 40
<223> Xaa = Any Amino Acid

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 49
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Xaa Trp Tyr Gln Gln Lys Pro Gly Lys
            20                  25                  30          
Ala Pro Lys Leu Leu Ile Tyr Xaa Gly Val Pro Ser Arg Phe Ser Gly
        35                  40                  45              
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
    50                  55                  60                  
Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu
65                  70                  75                  80  
Ile Lys
        


<210> 50
<211> 80
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 50
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly Gln Ser
            20                  25                  30          
Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly
        35                  40                  45              
Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp
    50                  55                  60                  
Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
65                  70                  75                  80  


<210> 51
<211> 80
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 51
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ala
            20                  25                  30          
Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly
        35                  40                  45              
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp
    50                  55                  60                  
Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
65                  70                  75                  80  


<210> 52
<211> 80
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 52
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly Gln Pro
            20                  25                  30          
Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly
        35                  40                  45              
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp
    50                  55                  60                  
Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
65                  70                  75                  80  


<210> 53
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys
            20              


<210> 54
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 54
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 55
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 55
Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 56
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
 1               5                  10  


<210> 57
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 58
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 58
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
 1               5                  10              


<210> 59
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 59
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LIGHT CHAIN FRAMEWORK REGION

<400> 60
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      

