                         SEQUENCE LISTING

<110>  Schering Corporation
       Presta, Leonard G.
 
<120>  Engineered Anti-IL-23R Antibodies

<130>  BP06537WO01

<150>  60/892,104
<151>  2007-02-28

<150>  60/945,183
<151>  2007-06-20

<160>  58    

<170>  PatentIn version 3.4

<210>  1
<211>  117
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(106)

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asn Ser 
            20                  25                  30          


Trp Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Asp Asn Ser Gly Tyr Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  119
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(68)

<220>
<221>  CDRH3
<222>  (101)..(108)

<400>  2

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Val Ser Gly Phe Asp Phe Asn Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Leu Val 
        35                  40                  45              


Ala Asp Ile Asn Ser Lys Ser Tyr Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Val Tyr Leu Glu Met Asp Asn Leu Lys Thr Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Thr Val His His Ser Asp Tyr Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  128
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  CDRH1
<222>  (26)..(37)

<220>
<221>  CDRH2
<222>  (52)..(67)

<220>
<221>  CDRH3
<222>  (100)..(117)

<400>  3

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Asp Ala His Pro Met Gly Ile Thr Thr Pro Asp Tyr 
            100                 105                 110         


Tyr Val Val Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125             


<210>  4
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(109)

<400>  4

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ala Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  119
<212>  PRT
<213>  Mus musculus


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(108)

<400>  5

Gln Val Pro Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Tyr Asp Tyr Asp Gly Val Pro Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  6
<211>  108
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  CDRL1
<222>  (24)..(34)

<220>
<221>  CDRL2
<222>  (50)..(56)

<220>
<221>  CDRL3
<222>  (89)..(97)

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Asn Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ser Ile Tyr Phe Cys Gln Gln Asn Tyr Tyr Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  7
<211>  108
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  CDRL1
<222>  (24)..(34)

<220>
<221>  CDRL2
<222>  (50)..(56)

<220>
<221>  CDRL3
<222>  (89)..(97)

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr His Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  8
<211>  108
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  CDRL1
<222>  (24)..(34)

<220>
<221>  CDRL2
<222>  (50)..(56)

<220>
<221>  CDRL3
<222>  (89)..(97)

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Thr Ser Met Ser Ile Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Asn Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Thr Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ser Val Tyr Tyr Cys Met Gln Ser Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  CDRL1
<222>  (24)..(40)

<220>
<221>  CDRL2
<222>  (56)..(62)

<220>
<221>  CDRL3
<222>  (95)..(103)

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Ile Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  10
<211>  108
<212>  PRT
<213>  Mus musculus


<220>
<221>  CDRL1
<222>  (24)..(34)

<220>
<221>  CDRL2
<222>  (50)..(56)

<220>
<221>  CDRL3
<222>  (89)..(97)

<400>  10

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Asp Asn Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg 
            100                 105             


<210>  11
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Gly Phe Thr Phe Asn Asn Ser Trp Met Thr 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Gly Phe Asp Phe Asn Ser Tyr Gly Met Ser 
1               5                   10  


<210>  13
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Gly Phe Ser Leu Ser Thr Tyr Gly Met Gly Val Gly 
1               5                   10          


<210>  14
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Tyr Thr Phe Thr Asn Tyr Ala Met Asn 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile His 
1               5                   10  


<210>  16
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Ser Ile Thr Asn Thr Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  19
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Asp Ile Asn Ser Lys Ser Tyr Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  18
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  19
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  19

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ser Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  20

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Glu Asp Asn Ser Gly Tyr Asp Tyr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  22

His His Ser Asp Tyr Phe Glu Tyr 
1               5               


<210>  23
<211>  18
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Ile Asp Ala His Pro Met Gly Ile Thr Thr Pro Asp Tyr Tyr Val Val 
1               5                   10                  15      


Asp Ala 
        


<210>  24
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  24

Gly Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  25
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  25

Ser Leu Tyr Asp Tyr Asp Gly Val Pro Asp 
1               5                   10  


<210>  26
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Leu Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  27

Leu Ala Ser Glu Asp Ile Tyr Asn Asn Leu Ala 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Lys Ala Ser Gln Asn Val Gly Ser Asn Val Asp 
1               5                   10      


<210>  29
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  29

Lys Ser Ser Gln Ser Leu Phe Asn Ser Ile Asn Gln Lys Thr Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  30
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  30

His Ala Ser Gln Gly Ile Asp Asn Asn Ile Gly 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  31

Tyr Ala Asn Ser Leu Asn Asp 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  32

His Ala Ser Ser Leu Gln Asp 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Lys Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  34

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  35

His Gly Thr Asn Leu Glu Asp 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Gln Gln Asn Tyr Tyr Ser Pro Pro Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Leu Gln Asp Ser Glu Tyr Pro Pro Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  38

Met Gln Ser Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  39

Gln Gln His Tyr Asp Thr Pro Trp Thr 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  40

Val Gln Tyr Ala Gln Phe Pro Phe Thr 
1               5                   


<210>  41
<211>  629
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  41

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Pro Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  42
<211>  644
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  42

Met Ser His Leu Thr Leu Gln Leu His Val Val Ile Ala Leu Tyr Val 
1               5                   10                  15      


Leu Phe Arg Trp Cys His Gly Gly Ile Thr Ser Ile Asn Cys Ser Gly 
            20                  25                  30          


Asp Met Trp Val Glu Pro Gly Glu Ile Phe Gln Met Gly Met Asn Val 
        35                  40                  45              


Ser Ile Tyr Cys Gln Glu Ala Leu Lys His Cys Arg Pro Arg Asn Leu 
    50                  55                  60                  


Tyr Phe Tyr Lys Asn Gly Phe Lys Glu Glu Phe Asp Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Arg Thr Thr Ala Arg Ile Trp Tyr Lys Gly Phe Ser Glu Pro His 
                85                  90                  95      


Ala Tyr Met His Cys Thr Ala Glu Cys Pro Gly His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly His Pro Pro Asp Ala Pro 
        115                 120                 125             


Ser Asn Leu Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Thr Gly Lys Pro Thr Tyr Ile Asp Thr Lys Tyr Ile Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Ala Ser 
                165                 170                 175     


Ser Tyr Val Lys Ile Ser Thr Asp Ser Leu Gln Gly Ser Arg Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Val Asn Ser Leu Gly Met Glu Asn Ser Gln 
        195                 200                 205             


Gln Leu His Val His Leu Asp Asp Ile Val Ile Pro Ser Ala Ser Ile 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Thr Asn Asp Thr Val Pro Lys Thr Ile Val 
225                 230                 235                 240 


Tyr Trp Lys Ser Lys Thr Met Ile Glu Lys Val Phe Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Thr Thr Thr Asn Gln Thr Trp Ser Val Lys Glu Phe Asp Ala 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asp Ser 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Asn Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Pro Phe Val His Gln Thr Ser Gln Glu Thr Gly 
305                 310                 315                 320 


Lys Arg Asn Trp Gln Pro Trp Ser Ser Pro Phe Val His Gln Thr Ser 
                325                 330                 335     


Gln Thr Val Ser Gln Val Thr Ala Lys Ser Ser His Glu Pro Gln Lys 
            340                 345                 350         


Met Glu Met Leu Ser Ala Thr Ile Phe Arg Gly His Pro Ala Ser Gly 
        355                 360                 365             


Asn His Gln Asp Ile Gly Leu Leu Ser Gly Met Val Phe Leu Ala Ile 
    370                 375                 380                 


Met Leu Pro Ile Phe Ser Leu Ile Gly Ile Phe Asn Arg Ser Leu Arg 
385                 390                 395                 400 


Ile Gly Ile Lys Arg Lys Val Leu Leu Met Ile Pro Lys Trp Leu Tyr 
                405                 410                 415     


Glu Asp Ile Pro Asn Met Glu Asn Ser Asn Val Ala Lys Leu Leu Gln 
            420                 425                 430         


Glu Lys Ser Val Phe Glu Asn Asp Asn Ala Ser Glu Gln Ala Leu Tyr 
        435                 440                 445             


Val Asp Pro Val Leu Thr Glu Ile Ser Glu Ile Ser Pro Leu Glu His 
    450                 455                 460                 


Lys Pro Thr Asp Tyr Lys Glu Glu Arg Leu Thr Gly Leu Leu Glu Thr 
465                 470                 475                 480 


Arg Asp Cys Pro Leu Gly Met Leu Ser Thr Ser Ser Ser Val Val Tyr 
                485                 490                 495     


Ile Pro Asp Leu Asn Thr Gly Tyr Lys Pro Gln Val Ser Asn Val Pro 
            500                 505                 510         


Pro Gly Gly Asn Leu Phe Ile Asn Arg Asp Glu Arg Asp Pro Thr Ser 
        515                 520                 525             


Leu Glu Thr Thr Asp Asp His Phe Ala Arg Leu Lys Thr Tyr Pro Asn 
    530                 535                 540                 


Phe Gln Phe Ser Ala Ser Ser Met Ala Leu Leu Asn Lys Thr Leu Ile 
545                 550                 555                 560 


Leu Asp Glu Leu Cys Leu Val Leu Asn Gln Gly Glu Phe Asn Ser Leu 
                565                 570                 575     


Asp Ile Lys Asn Ser Arg Gln Glu Glu Thr Ser Ile Val Leu Gln Ser 
            580                 585                 590         


Asp Ser Pro Ser Glu Thr Ile Pro Ala Gln Thr Leu Leu Ser Asp Glu 
        595                 600                 605             


Phe Val Ser Cys Leu Ala Ile Gly Asn Glu Asp Leu Pro Ser Ile Asn 
    610                 615                 620                 


Ser Tyr Phe Pro Gln Asn Val Leu Glu Ser His Phe Ser Arg Ile Ser 
625                 630                 635                 640 


Leu Phe Gln Lys 
                


<210>  43
<211>  662
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  43

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  44
<211>  738
<212>  PRT
<213>  Mus musculus


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  44

Met Asp Met Met Gly Leu Pro Gly Thr Ser Lys His Ile Thr Phe Leu 
1               5                   10                  15      


Leu Leu Cys Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val 
            20                  25                  30          


Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro 
        35                  40                  45              


Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser 
    50                  55                  60                  


Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys 
65                  70                  75                  80  


Cys Phe Val Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg 
                85                  90                  95      


Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp 
            100                 105                 110         


Gly Ile Pro Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu 
        115                 120                 125             


Gly Asn Arg Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn 
    130                 135                 140                 


Trp Thr Lys Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser 
145                 150                 155                 160 


His Gly Gln Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala 
                165                 170                 175     


Glu Val Gln Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly 
            180                 185                 190         


Asp Cys Gly Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile 
        195                 200                 205             


Cys Gly Ser Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala 
    210                 215                 220                 


Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro 
225                 230                 235                 240 


Gly Gly Pro Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu 
                245                 250                 255     


Val Leu Pro Gln Ala Lys Ile Lys Phe Leu Val Glu Pro Leu Asn Gln 
            260                 265                 270         


Gly Gly Arg Arg Arg Leu Thr Met Gln Gly Gln Ser Pro Gln Leu Ala 
        275                 280                 285             


Val Pro Glu Gly Cys Arg Gly Arg Pro Gly Ala Gln Val Lys Lys His 
    290                 295                 300                 


Leu Val Leu Val Arg Met Leu Ser Cys Arg Cys Gln Ala Gln Thr Ser 
305                 310                 315                 320 


Lys Thr Val Pro Leu Gly Lys Lys Leu Asn Leu Ser Gly Ala Thr Tyr 
                325                 330                 335     


Asp Leu Asn Val Leu Ala Lys Thr Arg Phe Gly Arg Ser Thr Ile Gln 
            340                 345                 350         


Lys Trp His Leu Pro Ala Gln Glu Leu Thr Glu Thr Arg Ala Leu Asn 
        355                 360                 365             


Val Ser Val Gly Gly Asn Met Thr Ser Met Gln Trp Ala Ala Gln Ala 
    370                 375                 380                 


Pro Gly Thr Thr Tyr Cys Leu Glu Trp Gln Pro Trp Phe Gln His Arg 
385                 390                 395                 400 


Asn His Thr His Cys Thr Leu Ile Val Pro Glu Glu Glu Asp Pro Ala 
                405                 410                 415     


Lys Met Val Thr His Ser Trp Ser Ser Lys Pro Thr Leu Glu Gln Glu 
            420                 425                 430         


Glu Cys Tyr Arg Ile Thr Val Phe Ala Ser Lys Asn Pro Lys Asn Pro 
        435                 440                 445             


Met Leu Trp Ala Thr Val Leu Ser Ser Tyr Tyr Phe Gly Gly Asn Ala 
    450                 455                 460                 


Ser Arg Ala Gly Thr Pro Arg His Val Ser Val Arg Asn Gln Thr Gly 
465                 470                 475                 480 


Asp Ser Val Ser Val Glu Trp Thr Ala Ser Gln Leu Ser Thr Cys Pro 
                485                 490                 495     


Gly Val Leu Thr Gln Tyr Val Val Arg Cys Glu Ala Glu Asp Gly Ala 
            500                 505                 510         


Trp Glu Ser Glu Trp Leu Val Pro Pro Thr Lys Thr Gln Val Thr Leu 
        515                 520                 525             


Asp Gly Leu Arg Ser Arg Val Met Tyr Lys Val Gln Val Arg Ala Asp 
    530                 535                 540                 


Thr Ala Arg Leu Pro Gly Ala Trp Ser His Pro Gln Arg Phe Ser Phe 
545                 550                 555                 560 


Glu Val Gln Ile Ser Arg Leu Ser Ile Ile Phe Ala Ser Leu Gly Ser 
                565                 570                 575     


Phe Ala Ser Val Leu Leu Val Gly Ser Leu Gly Tyr Ile Gly Leu Asn 
            580                 585                 590         


Arg Ala Ala Trp His Leu Cys Pro Pro Leu Pro Thr Pro Cys Gly Ser 
        595                 600                 605             


Thr Ala Val Glu Phe Pro Gly Ser Gln Gly Lys Gln Ala Trp Gln Trp 
    610                 615                 620                 


Cys Asn Pro Glu Asp Phe Pro Glu Val Leu Tyr Pro Arg Asp Ala Leu 
625                 630                 635                 640 


Val Val Glu Met Pro Gly Asp Arg Gly Asp Gly Thr Glu Ser Pro Gln 
                645                 650                 655     


Ala Ala Pro Glu Cys Ala Leu Asp Thr Arg Arg Pro Leu Glu Thr Gln 
            660                 665                 670         


Arg Gln Arg Gln Val Gln Ala Leu Ser Glu Ala Arg Arg Leu Gly Leu 
        675                 680                 685             


Ala Arg Glu Asp Cys Pro Arg Gly Asp Leu Ala His Val Thr Leu Pro 
    690                 695                 700                 


Leu Leu Leu Gly Gly Val Thr Gln Gly Ala Ser Val Leu Asp Asp Leu 
705                 710                 715                 720 


Trp Arg Thr His Lys Thr Ala Glu Pro Gly Pro Pro Thr Leu Gly Gln 
                725                 730                 735     


Glu Ala 
        


<210>  45
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(109)

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  46
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks with T72L substitution


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(109)

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  47
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks with M70F and T72L substitutions


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(109)

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  48
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks (subgroup IV)


<220>
<221>  CDRL1
<222>  (24)..(40)

<220>
<221>  CDRL2
<222>  (56)..(62)

<220>
<221>  CDRL3
<222>  (95)..(103)

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Ile Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr 
        115 


<210>  49
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks (subgroup II)


<220>
<221>  CDRL1
<222>  (24)..(40)

<220>
<221>  CDRL2
<222>  (56)..(62)

<220>
<221>  CDRL3
<222>  (95)..(103)

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Ile Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr 
        115 


<210>  50
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks with M70F and T72L substitutions


<220>
<221>  CDRH1
<222>  (26)..(35)

<220>
<221>  CDRH2
<222>  (50)..(66)

<220>
<221>  CDRH3
<222>  (99)..(109)

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  51
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks (subgroup II)


<220>
<221>  CDRL1
<222>  (24)..(40)

<220>
<221>  CDRL2
<222>  (56)..(62)

<220>
<221>  CDRL3
<222>  (95)..(103)

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Ile Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mus musculus with Thr at position 9 rather than Ser

<400>  52

Lys Ser Ser Gln Ser Leu Phe Asn Thr Ile Asn Gln Lys Thr Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  53
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks (subgroup II) with S32T 
       substitution


<220>
<221>  CDRL1
<222>  (24)..(40)

<220>
<221>  CDRL2
<222>  (56)..(62)

<220>
<221>  CDRL3
<222>  (95)..(103)

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Thr 
            20                  25                  30          


Ile Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr 
        115 


<210>  54
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks (subgroup II) with S32T 
       substitution


<220>
<221>  CDRL1
<222>  (24)..(40)

<220>
<221>  CDRL2
<222>  (56)..(62)

<220>
<221>  CDRL3
<222>  (95)..(103)

<400>  54

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Thr 
            20                  25                  30          


Ile Asn Gln Lys Thr Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asp Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  55
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks with changes encoding M70F and 
       T72L substitutions

<400>  55
atggccgtgc tgggcctgct gttctgcctg gtgaccttcc ccagctgcgt gctgtcccag     60

gtgcagctgg tgcagagcgg agccgaggtg aagaagccag gcgccagcgt caaggtgtcc    120

tgcaaggcca gcggctacac cttcaccaac tacgccatga actgggtgcg gcaggcccct    180

ggacagggac tggaatggat gggctggatc aacacctaca ccggcgagcc cacctacagc    240

gacgacttca agggcagggt gaccttcacc ctggacacca gcaccagcac cgcctacatg    300

gaactgagaa gcctgagatc cgacgacacc gccgtgtact actgcgccag aggcggcgga    360

tacgacgagg actacttcga ctactgggga cagggcaccc tggtgaccgt gagcagcgct    420

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac ctctggcggc    480

acagctgccc tcggctgtct ggtgaaggac tactttcccg agcccgtgac cgtgtcctgg    540

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    600

ctgtacagcc tgagcagcgt ggtgacagtg cccagctcta gcctgggaac ccagacctac    660

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag    720

agctgcgaca agacccacac ctgccccccc tgcccagctc cagaactcct gggcggaccc    780

tccgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag    840

gtgacctgcg tggtggtgga cgtgagccac gaggacccag aggtgaagtt caactggtac    900

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggaaca gtacaacagc    960

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag   1020

tacaagtgca aggtctccaa caaggccctg ccagccccca tcgagaaaac catcagcaag   1080

gccaagggcc agccacggga gccccaggtg tacaccctgc ccccctcccg ggacgagctg   1140

accaagaacc aggtgtccct gacatgcctg gtgaagggct tctaccccag cgacatcgcc   1200

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1260

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag caggtggcag   1320

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag   1380

aagagcctga gcctgtcccc cggcaagtga                                    1410


<210>  56
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human frameworks (group II) with S32T substitution

<400>  56
atggcccccg tgcagctgct gggcctgctg gtgctgttcc tgcccgccat gagatgcgac     60

atcgtgatga cccagagccc cctgagcctg cccgtgaccc caggcgagcc cgccagcatc    120

agctgcaaga gcagccagag cctgttcaac accatcaacc agaaaaccta cctggcctgg    180

tatctgcaga agcccggcca gtccccccag ctgctgatct acttcgccag cacccgggag    240

agcggcgtgc ccgacaggtt cagcggcagc ggctccggca ccgacttcac cctgaagatc    300

agcagggtgg aggccgagga cgtgggcgtg tactactgcc agcagcacta cgacaccccc    360

tggaccttcg gccagggcac caaggtggag atcaagcgta cggtggctgc ccccagcgtg    420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg    480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg    600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag    660

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgctga    720


<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat CDRs and human frameworks

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Ser Lys Ser Tyr Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His His Ser Asp Tyr Phe Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat CDRs and human frameworks

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Glu Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


