                               SEQUENCE LISTING

<110> ADVANCED VISION THERAPIES, INC.
 
<120> TREATMENT OF DISEASES CHARACTERIZED BY INFLAMMATION

<130> 116566-181

<140>
<141>

<150> 60/985,024
<151> 2007-11-02

<150> 60/892,395
<151> 2007-03-01

<160> 27    

<170> PatentIn version 3.3

<210> 1
<211> 2368
<212> DNA
<213> Homo sapiens

<400> 1
tcctgcccca ggcccagctt ctctcctgcc ttccaacgcc atggggagca atctcagccc     60

ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc    120

atggtctttg gcccggcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg    180

ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta    240

cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac    300

tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca    360

cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat    420

ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt    480

gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa    540

cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt    600

cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga    660

aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc    720

tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc    780

tgaggatggg cacggcccag gggaacaaca gaagcggaag atcgtcctgg acccttcagg    840

ctccatgaac atctacctgg tgctagatgg atcagacagc attggggcca gcaacttcac    900

aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc    960

aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc   1020

agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca   1080

caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag   1140

ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat   1200

gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga   1260

cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt   1320

gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga   1380

caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca   1440

aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg   1500

taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg   1560

acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg   1620

tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga   1680

cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc   1740

aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa   1800

atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt   1860

gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga   1920

tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat   1980

caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga   2040

caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag   2100

tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa   2160

gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa   2220

ccagaagcgg caaaagcagg tacctgctca cgcccgagac tttcacatca acctctttca   2280

agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tataaggggt   2340

ttcctgctgg acaggggcgt gggattga                                      2368


<210> 2
<211> 764
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210> 3
<211> 2368
<212> DNA
<213> Homo sapiens

<400> 3
tcctgcccca ggcccagctt ctctcctgcc ttccaacgcc atggggagca atctcagccc     60

ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc    120

atggtctttg gcccggcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg    180

ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta    240

cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac    300

tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca    360

cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat    420

ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt    480

gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa    540

cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt    600

cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga    660

aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc    720

tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc    780

tgaggatggg cacggcccag gggaacaaca gaagcggaag atcgtcctgg acccttcagg    840

ctccatgaac atctacctgg tgctagatgg atcagacagc attggggcca gcaacttcac    900

aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc    960

aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc   1020

agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca   1080

caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag   1140

ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat   1200

gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga   1260

cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt   1320

gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga   1380

caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca   1440

aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg   1500

taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg   1560

acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg   1620

tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga   1680

cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc   1740

aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa   1800

atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt   1860

gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga   1920

tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat   1980

caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga   2040

caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag   2100

tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa   2160

gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa   2220

ccagaagcgg caaaagcagg tacctgctca cgcccgaaac tttcacatca acctctttca   2280

agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tatgaggggt   2340

ttcctgctgg acaggggcgt gggattga                                      2368


<210> 4
<211> 764
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asn Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210> 5
<211> 2368
<212> DNA
<213> Homo sapiens

<400> 5
tcctgcccca ggcccagctt ctctcctgcc ttccaacgcc atggggagca atctcagccc     60

ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc    120

atggtctttg gcccggcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg    180

ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta    240

cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac    300

tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca    360

cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat    420

ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt    480

gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa    540

cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt    600

cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga    660

aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc    720

tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc    780

tgaggatggg cacggcccag gggaacaaca gaagcggaag atcgtcctgg acccttcagg    840

ctccatgaac atctacctgg tgctagatgg atcaggcagc attggggcca gcgacttcac    900

aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc    960

aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc   1020

agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca   1080

caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag   1140

ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat   1200

gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga   1260

cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt   1320

gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga   1380

caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca   1440

aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg   1500

taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg   1560

acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg   1620

tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga   1680

cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc   1740

aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa   1800

atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt   1860

gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga   1920

tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat   1980

caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga   2040

caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag   2100

tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa   2160

gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa   2220

ccagaagcgg caaaagcagg tacctgctca cgcccgaaac tttcacatca acctctttca   2280

agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tatgaggggt   2340

ttcctgctgg acaggggcgt gggattga                                      2368


<210> 6
<211> 764
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Gly Ser Ile Gly Ala Ser Asp Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asn Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210> 7
<211> 2368
<212> DNA
<213> Homo sapiens

<400> 7
tcctgcccca ggcccagctt ctctcctgcc ttccaacgcc atggggagca atctcagccc     60

ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc    120

atggtctttg gcccggcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg    180

ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta    240

cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac    300

tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca    360

cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat    420

ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt    480

gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa    540

cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt    600

cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga    660

aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc    720

tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc    780

tgaggatggg cacggcccag gggaacaaca ggcggcagcg atcgtcctgg acccttcagg    840

ctccatgaac atctacctgg tgctagatgg atcaggcagc attggggcca gcgacttcac    900

aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc    960

aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc   1020

agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca   1080

caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag   1140

ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat   1200

gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga   1260

cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt   1320

gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga   1380

caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca   1440

aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg   1500

taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg   1560

acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg   1620

tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga   1680

cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc   1740

aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa   1800

atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt   1860

gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga   1920

tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat   1980

caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga   2040

caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag   2100

tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa   2160

gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa   2220

ccagaagcgg caaaagcagg tacctgctca cgcccgagac tttcacatca acctctttca   2280

agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tatgaggggt   2340

ttcctgctgg acaggggcgt gggattga                                      2368


<210> 8
<211> 764
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Ala Ala Ala Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Gly Ser Ile Gly Ala Ser Asp Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210> 9
<211> 2428
<212> DNA
<213> Mus sp.

<400> 9
tgtagccaga tccagcattt gggtttcagt ttggacagga ggtcaaatag gcacccagag     60

tgacctggag agggctttgg gccactggac tctctggtgc tttccatgac aatggagagc    120

ccccagctct gcctcgtcct cttggtctta ggcttctcct ctggaggtgt gagcgcaact    180

ccagtgcttg aggcccggcc ccaagtctcc tgctctctgg agggagtaga gatcaaaggc    240

ggctcctttc aacttctcca aggcggtcag gccctggagt acctatgtcc ctctggcttc    300

tacccatacc ccgtgcagac tcgaacctgc agatccacag gctcctggag cgacctgcag    360

acccgagacc aaaagattgt ccagaaggcg gaatgcagag caatacgctg cccacgaccg    420

caggactttg aaaatgggga attctggccc cggtccccct tctacaacct gagtgaccag    480

atttcttttc aatgctatga tggttacgtt ctccggggct ctgctaatcg cacctgccaa    540

gagaatggcc ggtgggatgg gcaaacagca atttgtgatg atggagctgg atactgtccc    600

aatcccggta ttcctattgg gacaaggaag gtgggtagcc aataccgcct tgaagacatt    660

gttacttacc actgcagccg gggacttgtc ctgcgtggct cccagaagcg aaagtgtcaa    720

gaaggtggct catggagtgg gacagagcct tcctgccaag attccttcat gtatgacagc    780

cctcaagaag tggccgaagc attcctatcc tccctgacag agaccatcga aggagccgat    840

gctgaggatg ggcacagccc aggagaacag cagaagagga agattgtcct agacccctcg    900

ggctccatga atatctacct ggtgctagat ggatcagaca gcatcggaag cagcaacttc    960

acaggggcta agcggtgcct caccaacttg attgagaagg tggcgagtta cggggtgagg   1020

ccacgatatg gtctcctgac atatgctaca gtccccaaag tgttggtcag agtgtctgat   1080

gagaggagta gcgatgccga ctgggtcaca gagaagctca accaaatcag ttatgaagac   1140

cacaagctga agtcagggac caacaccaag agggctctcc aggctgtgta tagcatgatg   1200

agctgggcag gggatgcccc gcctgaaggc tggaatagaa cccgccatgt catcatcatt   1260

atgactgatg gcttgcacaa catgggtgga aaccctgtca ctgtcattca ggacatccga   1320

gccttgctgg acatcggcag ggatcccaaa aatcccaggg aggattacct ggatgtgtat   1380

gtgtttgggg tcgggcctct ggtggactcc gtgaacatca atgccttagc ttccaaaaag   1440

gacaatgagc atcatgtgtt taaagtcaag gatatggaag acctggagaa tgttttctac   1500

caaatgattg atgaaaccaa atctctgagt ctctgtggca tggtgtggga gcataaaaaa   1560

ggcaacgatt atcataagca accatggcaa gccaagatct cagtcactcg ccctctgaaa   1620

ggacatgaga cctgtatggg ggccgtggtg tctgagtact tcgtgctgac agcagcgcac   1680

tgcttcatgg tggatgatca gaaacattcc atcaaggtca gcgtgggggg tcagaggcgg   1740

gacctggaga ttgaagaggt cctgttccac cccaaataca atattaatgg gaaaaaggca   1800

gaagggatcc ctgagttcta tgattatgat gtggccctag tcaagctcaa gaacaagctc   1860

aagtatggcc agactctcag gcccatctgt ctcccctgca cggagggaac cacacgagcc   1920

ttgaggcttc ctcagacagc cacctgcaag cagcacaagg aacagttgct ccctgtgaag   1980

gatgtcaaag ctctgtttgt atctgagcaa gggaagagcc tgactcggaa ggaggtgtac   2040

atcaagaatg gggacaagaa agccagttgt gagagagatg ctacaaaggc ccaaggctat   2100

gagaaggtca aagatgcctc tgaggtggtc actccacggt tcctctgcac aggaggggtg   2160

gatccctatg ctgaccccaa cacatgcaaa ggagattccg ggggccctct cattgttcac   2220

aagagaagcc gcttcattca agttggtgtg attagctggg gagtagtaga tgtctgcaga   2280

gaccagaggc ggcaacagct ggtaccctct tatgcccgga acttccacat caacctcttc   2340

caggtgctgc cctggctaaa ggacaagctc aaagatgagg atttgggttt tctatgaaga   2400

gcttcctgca gggagagtgt gaggacag                                      2428


<210> 10
<211> 761
<212> PRT
<213> Mus sp.

<400> 10
Met Glu Ser Pro Gln Leu Cys Leu Val Leu Leu Val Leu Gly Phe Ser 
1               5                   10                  15      


Ser Gly Gly Val Ser Ala Thr Pro Val Leu Glu Ala Arg Pro Gln Val 
            20                  25                  30          


Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser Phe Gln Leu 
        35                  40                  45              


Leu Gln Gly Gly Gln Ala Leu Glu Tyr Leu Cys Pro Ser Gly Phe Tyr 
    50                  55                  60                  


Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly Ser Trp Ser 
65                  70                  75                  80  


Asp Leu Gln Thr Arg Asp Gln Lys Ile Val Gln Lys Ala Glu Cys Arg 
                85                  90                  95      


Ala Ile Arg Cys Pro Arg Pro Gln Asp Phe Glu Asn Gly Glu Phe Trp 
            100                 105                 110         


Pro Arg Ser Pro Phe Tyr Asn Leu Ser Asp Gln Ile Ser Phe Gln Cys 
        115                 120                 125             


Tyr Asp Gly Tyr Val Leu Arg Gly Ser Ala Asn Arg Thr Cys Gln Glu 
    130                 135                 140                 


Asn Gly Arg Trp Asp Gly Gln Thr Ala Ile Cys Asp Asp Gly Ala Gly 
145                 150                 155                 160 


Tyr Cys Pro Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys Val Gly Ser 
                165                 170                 175     


Gln Tyr Arg Leu Glu Asp Ile Val Thr Tyr His Cys Ser Arg Gly Leu 
            180                 185                 190         


Val Leu Arg Gly Ser Gln Lys Arg Lys Cys Gln Glu Gly Gly Ser Trp 
        195                 200                 205             


Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr Asp Ser Pro 
    210                 215                 220                 


Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu Thr Ile Glu 
225                 230                 235                 240 


Gly Ala Asp Ala Glu Asp Gly His Ser Pro Gly Glu Gln Gln Lys Arg 
                245                 250                 255     


Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu 
            260                 265                 270         


Asp Gly Ser Asp Ser Ile Gly Ser Ser Asn Phe Thr Gly Ala Lys Arg 
        275                 280                 285             


Cys Leu Thr Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly Val Arg Pro 
    290                 295                 300                 


Arg Tyr Gly Leu Leu Thr Tyr Ala Thr Val Pro Lys Val Leu Val Arg 
305                 310                 315                 320 


Val Ser Asp Glu Arg Ser Ser Asp Ala Asp Trp Val Thr Glu Lys Leu 
                325                 330                 335     


Asn Gln Ile Ser Tyr Glu Asp His Lys Leu Lys Ser Gly Thr Asn Thr 
            340                 345                 350         


Lys Arg Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Ala Gly Asp 
        355                 360                 365             


Ala Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile Ile Ile Met 
    370                 375                 380                 


Thr Asp Gly Leu His Asn Met Gly Gly Asn Pro Val Thr Val Ile Gln 
385                 390                 395                 400 


Asp Ile Arg Ala Leu Leu Asp Ile Gly Arg Asp Pro Lys Asn Pro Arg 
                405                 410                 415     


Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu Val Asp 
            420                 425                 430         


Ser Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu His His 
        435                 440                 445             


Val Phe Lys Val Lys Asp Met Glu Asp Leu Glu Asn Val Phe Tyr Gln 
    450                 455                 460                 


Met Ile Asp Glu Thr Lys Ser Leu Ser Leu Cys Gly Met Val Trp Glu 
465                 470                 475                 480 


His Lys Lys Gly Asn Asp Tyr His Lys Gln Pro Trp Gln Ala Lys Ile 
                485                 490                 495     


Ser Val Thr Arg Pro Leu Lys Gly His Glu Thr Cys Met Gly Ala Val 
            500                 505                 510         


Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe Met Val Asp 
        515                 520                 525             


Asp Gln Lys His Ser Ile Lys Val Ser Val Gly Gly Gln Arg Arg Asp 
    530                 535                 540                 


Leu Glu Ile Glu Glu Val Leu Phe His Pro Lys Tyr Asn Ile Asn Gly 
545                 550                 555                 560 


Lys Lys Ala Glu Gly Ile Pro Glu Phe Tyr Asp Tyr Asp Val Ala Leu 
                565                 570                 575     


Val Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Leu Arg Pro Ile 
            580                 585                 590         


Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg Leu Pro Gln 
        595                 600                 605             


Thr Ala Thr Cys Lys Gln His Lys Glu Gln Leu Leu Pro Val Lys Asp 
    610                 615                 620                 


Val Lys Ala Leu Phe Val Ser Glu Gln Gly Lys Ser Leu Thr Arg Lys 
625                 630                 635                 640 


Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Ala Ser Cys Glu Arg Asp 
                645                 650                 655     


Ala Thr Lys Ala Gln Gly Tyr Glu Lys Val Lys Asp Ala Ser Glu Val 
            660                 665                 670         


Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Asp Pro Tyr Ala Asp 
        675                 680                 685             


Pro Asn Thr Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Val His Lys 
    690                 695                 700                 


Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly Val Val Asp 
705                 710                 715                 720 


Val Cys Arg Asp Gln Arg Arg Gln Gln Leu Val Pro Ser Tyr Ala Arg 
                725                 730                 735     


Asn Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu Lys Asp Lys 
            740                 745                 750         


Leu Lys Asp Glu Asp Leu Gly Phe Leu 
        755                 760     


<210> 11
<211> 2428
<212> DNA
<213> Mus sp.

<400> 11
tgtagccaga tccagcattt gggtttcagt ttggacagga ggtcaaatag gcacccagag     60

tgacctggag agggctttgg gccactggac tctctggtgc tttccatgac aatggagagc    120

ccccagctct gcctcgtcct cttggtctta ggcttctcct ctggaggtgt gagcgcaact    180

ccagtgcttg aggcccggcc ccaagtctcc tgctctctgg agggagtaga gatcaaaggc    240

ggctcctttc aacttctcca aggcggtcag gccctggagt acctatgtcc ctctggcttc    300

tacccatacc ccgtgcagac tcgaacctgc agatccacag gctcctggag cgacctgcag    360

acccgagacc aaaagattgt ccagaaggcg gaatgcagag caatacgctg cccacgaccg    420

caggactttg aaaatgggga attctggccc cggtccccct tctacaacct gagtgaccag    480

atttcttttc aatgctatga tggttacgtt ctccggggct ctgctaatcg cacctgccaa    540

gagaatggcc ggtgggatgg gcaaacagca atttgtgatg atggagctgg atactgtccc    600

aatcccggta ttcctattgg gacaaggaag gtgggtagcc aataccgcct tgaagacatt    660

gttacttacc actgcagccg gggacttgtc ctgcgtggct cccagaagcg aaagtgtcaa    720

gaaggtggct catggagtgg gacagagcct tcctgccaag attccttcat gtatgacagc    780

cctcaagaag tggccgaagc attcctatcc tccctgacag agaccatcga aggagccgat    840

gctgaggatg ggcacagccc aggagaacag cagaagagga agattgtcct agacccctcg    900

ggctccatga atatctacct ggtgctagat ggatcaggca gcatcggaag cagcgacttc    960

acaggggcta agcggtgcct caccaacttg attgagaagg tggcgagtta cggggtgagg   1020

ccacgatatg gtctcctgac atatgctaca gtccccaaag tgttggtcag agtgtctgat   1080

gagaggagta gcgatgccga ctgggtcaca gagaagctca accaaatcag ttatgaagac   1140

cacaagctga agtcagggac caacaccaag agggctctcc aggctgtgta tagcatgatg   1200

agctgggcag gggatgcccc gcctgaaggc tggaatagaa cccgccatgt catcatcatt   1260

atgactgatg gcttgcacaa catgggtgga aaccctgtca ctgtcattca ggacatccga   1320

gccttgctgg acatcggcag ggatcccaaa aatcccaggg aggattacct ggatgtgtat   1380

gtgtttgggg tcgggcctct ggtggactcc gtgaacatca atgccttagc ttccaaaaag   1440

gacaatgagc atcatgtgtt taaagtcaag gatatggaag acctggagaa tgttttctac   1500

caaatgattg atgaaaccaa atctctgagt ctctgtggca tggtgtggga gcataaaaaa   1560

ggcaacgatt atcataagca accatggcaa gccaagatct cagtcactcg ccctctgaaa   1620

ggacatgaga cctgtatggg ggccgtggtg tctgagtact tcgtgctgac agcagcgcac   1680

tgcttcatgg tggatgatca gaaacattcc atcaaggtca gcgtgggggg tcagaggcgg   1740

gacctggaga ttgaagaggt cctgttccac cccaaataca atattaatgg gaaaaaggca   1800

gaagggatcc ctgagttcta tgattatgat gtggccctag tcaagctcaa gaacaagctc   1860

aagtatggcc agactctcag gcccatctgt ctcccctgca cggagggaac cacacgagcc   1920

ttgaggcttc ctcagacagc cacctgcaag cagcacaagg aacagttgct ccctgtgaag   1980

gatgtcaaag ctctgtttgt atctgagcaa gggaagagcc tgactcggaa ggaggtgtac   2040

atcaagaatg gggacaagaa agccagttgt gagagagatg ctacaaaggc ccaaggctat   2100

gagaaggtca aagatgcctc tgaggtggtc actccacggt tcctctgcac aggaggggtg   2160

gatccctatg ctgaccccaa cacatgcaaa ggagattccg ggggccctct cattgttcac   2220

aagagaagcc gcttcattca agttggtgtg attagctggg gagtagtaga tgtctgcaga   2280

gaccagaggc ggcaacagct ggtaccctct tatgcccgga acttccacat caacctcttc   2340

caggtgctgc cctggctaaa ggacaagctc aaagatgagg atttgggttt tctatgaaga   2400

gcttcctgca gggagagtgt gaggacag                                      2428


<210> 12
<211> 761
<212> PRT
<213> Mus sp.

<400> 12
Met Glu Ser Pro Gln Leu Cys Leu Val Leu Leu Val Leu Gly Phe Ser 
1               5                   10                  15      


Ser Gly Gly Val Ser Ala Thr Pro Val Leu Glu Ala Arg Pro Gln Val 
            20                  25                  30          


Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser Phe Gln Leu 
        35                  40                  45              


Leu Gln Gly Gly Gln Ala Leu Glu Tyr Leu Cys Pro Ser Gly Phe Tyr 
    50                  55                  60                  


Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly Ser Trp Ser 
65                  70                  75                  80  


Asp Leu Gln Thr Arg Asp Gln Lys Ile Val Gln Lys Ala Glu Cys Arg 
                85                  90                  95      


Ala Ile Arg Cys Pro Arg Pro Gln Asp Phe Glu Asn Gly Glu Phe Trp 
            100                 105                 110         


Pro Arg Ser Pro Phe Tyr Asn Leu Ser Asp Gln Ile Ser Phe Gln Cys 
        115                 120                 125             


Tyr Asp Gly Tyr Val Leu Arg Gly Ser Ala Asn Arg Thr Cys Gln Glu 
    130                 135                 140                 


Asn Gly Arg Trp Asp Gly Gln Thr Ala Ile Cys Asp Asp Gly Ala Gly 
145                 150                 155                 160 


Tyr Cys Pro Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys Val Gly Ser 
                165                 170                 175     


Gln Tyr Arg Leu Glu Asp Ile Val Thr Tyr His Cys Ser Arg Gly Leu 
            180                 185                 190         


Val Leu Arg Gly Ser Gln Lys Arg Lys Cys Gln Glu Gly Gly Ser Trp 
        195                 200                 205             


Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr Asp Ser Pro 
    210                 215                 220                 


Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu Thr Ile Glu 
225                 230                 235                 240 


Gly Ala Asp Ala Glu Asp Gly His Ser Pro Gly Glu Gln Gln Lys Arg 
                245                 250                 255     


Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu 
            260                 265                 270         


Asp Gly Ser Gly Ser Ile Gly Ser Ser Asp Phe Thr Gly Ala Lys Arg 
        275                 280                 285             


Cys Leu Thr Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly Val Arg Pro 
    290                 295                 300                 


Arg Tyr Gly Leu Leu Thr Tyr Ala Thr Val Pro Lys Val Leu Val Arg 
305                 310                 315                 320 


Val Ser Asp Glu Arg Ser Ser Asp Ala Asp Trp Val Thr Glu Lys Leu 
                325                 330                 335     


Asn Gln Ile Ser Tyr Glu Asp His Lys Leu Lys Ser Gly Thr Asn Thr 
            340                 345                 350         


Lys Arg Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Ala Gly Asp 
        355                 360                 365             


Ala Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile Ile Ile Met 
    370                 375                 380                 


Thr Asp Gly Leu His Asn Met Gly Gly Asn Pro Val Thr Val Ile Gln 
385                 390                 395                 400 


Asp Ile Arg Ala Leu Leu Asp Ile Gly Arg Asp Pro Lys Asn Pro Arg 
                405                 410                 415     


Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu Val Asp 
            420                 425                 430         


Ser Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu His His 
        435                 440                 445             


Val Phe Lys Val Lys Asp Met Glu Asp Leu Glu Asn Val Phe Tyr Gln 
    450                 455                 460                 


Met Ile Asp Glu Thr Lys Ser Leu Ser Leu Cys Gly Met Val Trp Glu 
465                 470                 475                 480 


His Lys Lys Gly Asn Asp Tyr His Lys Gln Pro Trp Gln Ala Lys Ile 
                485                 490                 495     


Ser Val Thr Arg Pro Leu Lys Gly His Glu Thr Cys Met Gly Ala Val 
            500                 505                 510         


Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe Met Val Asp 
        515                 520                 525             


Asp Gln Lys His Ser Ile Lys Val Ser Val Gly Gly Gln Arg Arg Asp 
    530                 535                 540                 


Leu Glu Ile Glu Glu Val Leu Phe His Pro Lys Tyr Asn Ile Asn Gly 
545                 550                 555                 560 


Lys Lys Ala Glu Gly Ile Pro Glu Phe Tyr Asp Tyr Asp Val Ala Leu 
                565                 570                 575     


Val Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Leu Arg Pro Ile 
            580                 585                 590         


Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg Leu Pro Gln 
        595                 600                 605             


Thr Ala Thr Cys Lys Gln His Lys Glu Gln Leu Leu Pro Val Lys Asp 
    610                 615                 620                 


Val Lys Ala Leu Phe Val Ser Glu Gln Gly Lys Ser Leu Thr Arg Lys 
625                 630                 635                 640 


Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Ala Ser Cys Glu Arg Asp 
                645                 650                 655     


Ala Thr Lys Ala Gln Gly Tyr Glu Lys Val Lys Asp Ala Ser Glu Val 
            660                 665                 670         


Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Asp Pro Tyr Ala Asp 
        675                 680                 685             


Pro Asn Thr Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Val His Lys 
    690                 695                 700                 


Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly Val Val Asp 
705                 710                 715                 720 


Val Cys Arg Asp Gln Arg Arg Gln Gln Leu Val Pro Ser Tyr Ala Arg 
                725                 730                 735     


Asn Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu Lys Asp Lys 
            740                 745                 750         


Leu Lys Asp Glu Asp Leu Gly Phe Leu 
        755                 760     


<210> 13
<211> 2428
<212> DNA
<213> Mus sp.

<400> 13
tgtagccaga tccagcattt gggtttcagt ttggacagga ggtcaaatag gcacccagag     60

tgacctggag agggctttgg gccactggac tctctggtgc tttccatgac aatggagagc    120

ccccagctct gcctcgtcct cttggtctta ggcttctcct ctggaggtgt gagcgcaact    180

ccagtgcttg aggcccggcc ccaagtctcc tgctctctgg agggagtaga gatcaaaggc    240

ggctcctttc aacttctcca aggcggtcag gccctggagt acctatgtcc ctctggcttc    300

tacccatacc ccgtgcagac tcgaacctgc agatccacag gctcctggag cgacctgcag    360

acccgagacc aaaagattgt ccagaaggcg gaatgcagag caatacgctg cccacgaccg    420

caggactttg aaaatgggga attctggccc cggtccccct tctacaacct gagtgaccag    480

atttcttttc aatgctatga tggttacgtt ctccggggct ctgctaatcg cacctgccaa    540

gagaatggcc ggtgggatgg gcaaacagca atttgtgatg atggagctgg atactgtccc    600

aatcccggta ttcctattgg gacaaggaag gtgggtagcc aataccgcct tgaagacatt    660

gttacttacc actgcagccg gggacttgtc ctgcgtggct cccagaagcg aaagtgtcaa    720

gaaggtggct catggagtgg gacagagcct tcctgccaag attccttcat gtatgacagc    780

cctcaagaag tggccgaagc attcctatcc tccctgacag agaccatcga aggagccgat    840

gctgaggatg ggcacagccc aggagaacag caggcggcag cgattgtcct agacccctcg    900

ggctccatga atatctacct ggtgctagat ggatcaggca gcatcggaag cagcgacttc    960

acaggggcta agcggtgcct caccaacttg attgagaagg tggcgagtta cggggtgagg   1020

ccacgatatg gtctcctgac atatgctaca gtccccaaag tgttggtcag agtgtctgat   1080

gagaggagta gcgatgccga ctgggtcaca gagaagctca accaaatcag ttatgaagac   1140

cacaagctga agtcagggac caacaccaag agggctctcc aggctgtgta tagcatgatg   1200

agctgggcag gggatgcccc gcctgaaggc tggaatagaa cccgccatgt catcatcatt   1260

atgactgatg gcttgcacaa catgggtgga aaccctgtca ctgtcattca ggacatccga   1320

gccttgctgg acatcggcag ggatcccaaa aatcccaggg aggattacct ggatgtgtat   1380

gtgtttgggg tcgggcctct ggtggactcc gtgaacatca atgccttagc ttccaaaaag   1440

gacaatgagc atcatgtgtt taaagtcaag gatatggaag acctggagaa tgttttctac   1500

caaatgattg atgaaaccaa atctctgagt ctctgtggca tggtgtggga gcataaaaaa   1560

ggcaacgatt atcataagca accatggcaa gccaagatct cagtcactcg ccctctgaaa   1620

ggacatgaga cctgtatggg ggccgtggtg tctgagtact tcgtgctgac agcagcgcac   1680

tgcttcatgg tggatgatca gaaacattcc atcaaggtca gcgtgggggg tcagaggcgg   1740

gacctggaga ttgaagaggt cctgttccac cccaaataca atattaatgg gaaaaaggca   1800

gaagggatcc ctgagttcta tgattatgat gtggccctag tcaagctcaa gaacaagctc   1860

aagtatggcc agactctcag gcccatctgt ctcccctgca cggagggaac cacacgagcc   1920

ttgaggcttc ctcagacagc cacctgcaag cagcacaagg aacagttgct ccctgtgaag   1980

gatgtcaaag ctctgtttgt atctgagcaa gggaagagcc tgactcggaa ggaggtgtac   2040

atcaagaatg gggacaagaa agccagttgt gagagagatg ctacaaaggc ccaaggctat   2100

gagaaggtca aagatgcctc tgaggtggtc actccacggt tcctctgcac aggaggggtg   2160

gatccctatg ctgaccccaa cacatgcaaa ggagattccg ggggccctct cattgttcac   2220

aagagaagcc gcttcattca agttggtgtg attagctggg gagtagtaga tgtctgcaga   2280

gaccagaggc ggcaacagct ggtaccctct tatgcccggg acttccacat caacctcttc   2340

caggtgctgc cctggctaaa ggacaagctc aaagatgagg atttgggttt tctatgaaga   2400

gcttcctgca gggagagtgt gaggacag                                      2428


<210> 14
<211> 761
<212> PRT
<213> Mus sp.

<400> 14
Met Glu Ser Pro Gln Leu Cys Leu Val Leu Leu Val Leu Gly Phe Ser 
1               5                   10                  15      


Ser Gly Gly Val Ser Ala Thr Pro Val Leu Glu Ala Arg Pro Gln Val 
            20                  25                  30          


Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser Phe Gln Leu 
        35                  40                  45              


Leu Gln Gly Gly Gln Ala Leu Glu Tyr Leu Cys Pro Ser Gly Phe Tyr 
    50                  55                  60                  


Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly Ser Trp Ser 
65                  70                  75                  80  


Asp Leu Gln Thr Arg Asp Gln Lys Ile Val Gln Lys Ala Glu Cys Arg 
                85                  90                  95      


Ala Ile Arg Cys Pro Arg Pro Gln Asp Phe Glu Asn Gly Glu Phe Trp 
            100                 105                 110         


Pro Arg Ser Pro Phe Tyr Asn Leu Ser Asp Gln Ile Ser Phe Gln Cys 
        115                 120                 125             


Tyr Asp Gly Tyr Val Leu Arg Gly Ser Ala Asn Arg Thr Cys Gln Glu 
    130                 135                 140                 


Asn Gly Arg Trp Asp Gly Gln Thr Ala Ile Cys Asp Asp Gly Ala Gly 
145                 150                 155                 160 


Tyr Cys Pro Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys Val Gly Ser 
                165                 170                 175     


Gln Tyr Arg Leu Glu Asp Ile Val Thr Tyr His Cys Ser Arg Gly Leu 
            180                 185                 190         


Val Leu Arg Gly Ser Gln Lys Arg Lys Cys Gln Glu Gly Gly Ser Trp 
        195                 200                 205             


Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr Asp Ser Pro 
    210                 215                 220                 


Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu Thr Ile Glu 
225                 230                 235                 240 


Gly Ala Asp Ala Glu Asp Gly His Ser Pro Gly Glu Gln Gln Ala Ala 
                245                 250                 255     


Ala Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu 
            260                 265                 270         


Asp Gly Ser Gly Ser Ile Gly Ser Ser Asp Phe Thr Gly Ala Lys Arg 
        275                 280                 285             


Cys Leu Thr Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly Val Arg Pro 
    290                 295                 300                 


Arg Tyr Gly Leu Leu Thr Tyr Ala Thr Val Pro Lys Val Leu Val Arg 
305                 310                 315                 320 


Val Ser Asp Glu Arg Ser Ser Asp Ala Asp Trp Val Thr Glu Lys Leu 
                325                 330                 335     


Asn Gln Ile Ser Tyr Glu Asp His Lys Leu Lys Ser Gly Thr Asn Thr 
            340                 345                 350         


Lys Arg Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Ala Gly Asp 
        355                 360                 365             


Ala Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile Ile Ile Met 
    370                 375                 380                 


Thr Asp Gly Leu His Asn Met Gly Gly Asn Pro Val Thr Val Ile Gln 
385                 390                 395                 400 


Asp Ile Arg Ala Leu Leu Asp Ile Gly Arg Asp Pro Lys Asn Pro Arg 
                405                 410                 415     


Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu Val Asp 
            420                 425                 430         


Ser Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu His His 
        435                 440                 445             


Val Phe Lys Val Lys Asp Met Glu Asp Leu Glu Asn Val Phe Tyr Gln 
    450                 455                 460                 


Met Ile Asp Glu Thr Lys Ser Leu Ser Leu Cys Gly Met Val Trp Glu 
465                 470                 475                 480 


His Lys Lys Gly Asn Asp Tyr His Lys Gln Pro Trp Gln Ala Lys Ile 
                485                 490                 495     


Ser Val Thr Arg Pro Leu Lys Gly His Glu Thr Cys Met Gly Ala Val 
            500                 505                 510         


Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe Met Val Asp 
        515                 520                 525             


Asp Gln Lys His Ser Ile Lys Val Ser Val Gly Gly Gln Arg Arg Asp 
    530                 535                 540                 


Leu Glu Ile Glu Glu Val Leu Phe His Pro Lys Tyr Asn Ile Asn Gly 
545                 550                 555                 560 


Lys Lys Ala Glu Gly Ile Pro Glu Phe Tyr Asp Tyr Asp Val Ala Leu 
                565                 570                 575     


Val Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Leu Arg Pro Ile 
            580                 585                 590         


Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg Leu Pro Gln 
        595                 600                 605             


Thr Ala Thr Cys Lys Gln His Lys Glu Gln Leu Leu Pro Val Lys Asp 
    610                 615                 620                 


Val Lys Ala Leu Phe Val Ser Glu Gln Gly Lys Ser Leu Thr Arg Lys 
625                 630                 635                 640 


Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Ala Ser Cys Glu Arg Asp 
                645                 650                 655     


Ala Thr Lys Ala Gln Gly Tyr Glu Lys Val Lys Asp Ala Ser Glu Val 
            660                 665                 670         


Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Asp Pro Tyr Ala Asp 
        675                 680                 685             


Pro Asn Thr Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Val His Lys 
    690                 695                 700                 


Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly Val Val Asp 
705                 710                 715                 720 


Val Cys Arg Asp Gln Arg Arg Gln Gln Leu Val Pro Ser Tyr Ala Arg 
                725                 730                 735     


Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu Lys Asp Lys 
            740                 745                 750         


Leu Lys Asp Glu Asp Leu Gly Phe Leu 
        755                 760     


<210> 15
<211> 2428
<212> DNA
<213> Mus sp.

<400> 15
tgtagccaga tccagcattt gggtttcagt ttggacagga ggtcaaatag gcacccagag     60

tgacctggag agggctttgg gccactggac tctctggtgc tttccatgac aatggagagc    120

ccccagctct gcctcgtcct cttggtctta ggcttctcct ctggaggtgt gagcgcaact    180

ccagtgcttg aggcccggcc ccaagtctcc tgctctctgg agggagtaga gatcaaaggc    240

ggctcctttc aacttctcca aggcggtcag gccctggagt acctatgtcc ctctggcttc    300

tacccatacc ccgtgcagac tcgaacctgc agatccacag gctcctggag cgacctgcag    360

acccgagacc aaaagattgt ccagaaggcg gaatgcagag caatacgctg cccacgaccg    420

caggactttg aaaatgggga attctggccc cggtccccct tctacaacct gagtgaccag    480

atttcttttc aatgctatga tggttacgtt ctccggggct ctgctaatcg cacctgccaa    540

gagaatggcc ggtgggatgg gcaaacagca atttgtgatg atggagctgg atactgtccc    600

aatcccggta ttcctattgg gacaaggaag gtgggtagcc aataccgcct tgaagacatt    660

gttacttacc actgcagccg gggacttgtc ctgcgtggct cccagaagcg aaagtgtcaa    720

gaaggtggct catggagtgg gacagagcct tcctgccaag attccttcat gtatgacagc    780

cctcaagaag tggccgaagc attcctatcc tccctgacag agaccatcga aggagccgat    840

gctgaggatg ggcacagccc aggagaacag cagaagagga agattgtcct agacccctcg    900

ggctccatga atatctacct ggtgctagat ggatcagaca gcatcggaag cagcaacttc    960

acaggggcta agcggtgcct caccaacttg attgagaagg tggcgagtta cggggtgagg   1020

ccacgatatg gtctcctgac atatgctaca gtccccaaag tgttggtcag agtgtctgat   1080

gagaggagta gcgatgccga ctgggtcaca gagaagctca accaaatcag ttatgaagac   1140

cacaagctga agtcagggac caacaccaag agggctctcc aggctgtgta tagcatgatg   1200

agctgggcag gggatgcccc gcctgaaggc tggaatagaa cccgccatgt catcatcatt   1260

atgactgatg gcttgcacaa catgggtgga aaccctgtca ctgtcattca ggacatccga   1320

gccttgctgg acatcggcag ggatcccaaa aatcccaggg aggattacct ggatgtgtat   1380

gtgtttgggg tcgggcctct ggtggactcc gtgaacatca atgccttagc ttccaaaaag   1440

gacaatgagc atcatgtgtt taaagtcaag gatatggaag acctggagaa tgttttctac   1500

caaatgattg atgaaaccaa atctctgagt ctctgtggca tggtgtggga gcataaaaaa   1560

ggcaacgatt atcataagca accatggcaa gccaagatct cagtcactcg ccctctgaaa   1620

ggacatgaga cctgtatggg ggccgtggtg tctgagtact tcgtgctgac agcagcgcac   1680

tgcttcatgg tggatgatca gaaacattcc atcaaggtca gcgtgggggg tcagaggcgg   1740

gacctggaga ttgaagaggt cctgttccac cccaaataca atattaatgg gaaaaaggca   1800

gaagggatcc ctgagttcta tgattatgat gtggccctag tcaagctcaa gaacaagctc   1860

aagtatggcc agactctcag gcccatctgt ctcccctgca cggagggaac cacacgagcc   1920

ttgaggcttc ctcagacagc cacctgcaag cagcacaagg aacagttgct ccctgtgaag   1980

gatgtcaaag ctctgtttgt atctgagcaa gggaagagcc tgactcggaa ggaggtgtac   2040

atcaagaatg gggacaagaa agccagttgt gagagagatg ctacaaaggc ccaaggctat   2100

gagaaggtca aagatgcctc tgaggtggtc actccacggt tcctctgcac aggaggggtg   2160

gatccctatg ctgaccccaa cacatgcaaa ggagattccg ggggccctct cattgttcac   2220

aagagaagcc gcttcattca agttggtgtg attagctggg gagtagtaga tgtctgcaga   2280

gaccagaggc ggcaacagct ggtaccctct tatgcccggg acttccacat caacctcttc   2340

caggtgctgc cctggctaaa ggacaagctc aaagatgagg atttgggttt tctataaaga   2400

gcttcctgca gggagagtgt gaggacag                                      2428


<210> 16
<211> 761
<212> PRT
<213> Mus sp.

<400> 16
Met Glu Ser Pro Gln Leu Cys Leu Val Leu Leu Val Leu Gly Phe Ser 
1               5                   10                  15      


Ser Gly Gly Val Ser Ala Thr Pro Val Leu Glu Ala Arg Pro Gln Val 
            20                  25                  30          


Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser Phe Gln Leu 
        35                  40                  45              


Leu Gln Gly Gly Gln Ala Leu Glu Tyr Leu Cys Pro Ser Gly Phe Tyr 
    50                  55                  60                  


Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly Ser Trp Ser 
65                  70                  75                  80  


Asp Leu Gln Thr Arg Asp Gln Lys Ile Val Gln Lys Ala Glu Cys Arg 
                85                  90                  95      


Ala Ile Arg Cys Pro Arg Pro Gln Asp Phe Glu Asn Gly Glu Phe Trp 
            100                 105                 110         


Pro Arg Ser Pro Phe Tyr Asn Leu Ser Asp Gln Ile Ser Phe Gln Cys 
        115                 120                 125             


Tyr Asp Gly Tyr Val Leu Arg Gly Ser Ala Asn Arg Thr Cys Gln Glu 
    130                 135                 140                 


Asn Gly Arg Trp Asp Gly Gln Thr Ala Ile Cys Asp Asp Gly Ala Gly 
145                 150                 155                 160 


Tyr Cys Pro Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys Val Gly Ser 
                165                 170                 175     


Gln Tyr Arg Leu Glu Asp Ile Val Thr Tyr His Cys Ser Arg Gly Leu 
            180                 185                 190         


Val Leu Arg Gly Ser Gln Lys Arg Lys Cys Gln Glu Gly Gly Ser Trp 
        195                 200                 205             


Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr Asp Ser Pro 
    210                 215                 220                 


Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu Thr Ile Glu 
225                 230                 235                 240 


Gly Ala Asp Ala Glu Asp Gly His Ser Pro Gly Glu Gln Gln Lys Arg 
                245                 250                 255     


Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu 
            260                 265                 270         


Asp Gly Ser Asp Ser Ile Gly Ser Ser Asn Phe Thr Gly Ala Lys Arg 
        275                 280                 285             


Cys Leu Thr Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly Val Arg Pro 
    290                 295                 300                 


Arg Tyr Gly Leu Leu Thr Tyr Ala Thr Val Pro Lys Val Leu Val Arg 
305                 310                 315                 320 


Val Ser Asp Glu Arg Ser Ser Asp Ala Asp Trp Val Thr Glu Lys Leu 
                325                 330                 335     


Asn Gln Ile Ser Tyr Glu Asp His Lys Leu Lys Ser Gly Thr Asn Thr 
            340                 345                 350         


Lys Arg Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Ala Gly Asp 
        355                 360                 365             


Ala Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile Ile Ile Met 
    370                 375                 380                 


Thr Asp Gly Leu His Asn Met Gly Gly Asn Pro Val Thr Val Ile Gln 
385                 390                 395                 400 


Asp Ile Arg Ala Leu Leu Asp Ile Gly Arg Asp Pro Lys Asn Pro Arg 
                405                 410                 415     


Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu Val Asp 
            420                 425                 430         


Ser Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu His His 
        435                 440                 445             


Val Phe Lys Val Lys Asp Met Glu Asp Leu Glu Asn Val Phe Tyr Gln 
    450                 455                 460                 


Met Ile Asp Glu Thr Lys Ser Leu Ser Leu Cys Gly Met Val Trp Glu 
465                 470                 475                 480 


His Lys Lys Gly Asn Asp Tyr His Lys Gln Pro Trp Gln Ala Lys Ile 
                485                 490                 495     


Ser Val Thr Arg Pro Leu Lys Gly His Glu Thr Cys Met Gly Ala Val 
            500                 505                 510         


Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe Met Val Asp 
        515                 520                 525             


Asp Gln Lys His Ser Ile Lys Val Ser Val Gly Gly Gln Arg Arg Asp 
    530                 535                 540                 


Leu Glu Ile Glu Glu Val Leu Phe His Pro Lys Tyr Asn Ile Asn Gly 
545                 550                 555                 560 


Lys Lys Ala Glu Gly Ile Pro Glu Phe Tyr Asp Tyr Asp Val Ala Leu 
                565                 570                 575     


Val Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Leu Arg Pro Ile 
            580                 585                 590         


Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg Leu Pro Gln 
        595                 600                 605             


Thr Ala Thr Cys Lys Gln His Lys Glu Gln Leu Leu Pro Val Lys Asp 
    610                 615                 620                 


Val Lys Ala Leu Phe Val Ser Glu Gln Gly Lys Ser Leu Thr Arg Lys 
625                 630                 635                 640 


Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Ala Ser Cys Glu Arg Asp 
                645                 650                 655     


Ala Thr Lys Ala Gln Gly Tyr Glu Lys Val Lys Asp Ala Ser Glu Val 
            660                 665                 670         


Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Asp Pro Tyr Ala Asp 
        675                 680                 685             


Pro Asn Thr Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Val His Lys 
    690                 695                 700                 


Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly Val Val Asp 
705                 710                 715                 720 


Val Cys Arg Asp Gln Arg Arg Gln Gln Leu Val Pro Ser Tyr Ala Arg 
                725                 730                 735     


Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu Lys Asp Lys 
            740                 745                 750         


Leu Lys Asp Glu Asp Leu Gly Phe Leu 
        755                 760     


<210> 17
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
ctagctagct cctgccccag gcccagcttc tctcc                                35


<210> 18
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 18
ctagctagct caatcccacg cccctgtcc                                       29


<210> 19
<211> 7912
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide

<400> 19
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg    540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg    600

taaaacgacg gccagtgagc gcgcgagctc caccgcggtg gcggccgctc tagaactctc    660

agtacaatct gctctgatgc cgcatagtta agccagtatc tgctccctgc ttgtgtgttg    720

gaggtcgctg agtagtgcgc gagcaaaatt taagctacaa caaggcaagg cttgaccgac    780

aattgcatga agaatctgct tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc    840

agatatacgc gtatctgagg ggactagggt gtgtttaggc gaaaagcggg gcttcggttg    900

tacgcggtta ggagtcccct caggatatag tagtttcgct tttgcatagg gagggggaaa    960

tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg   1020

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc   1080

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattcc   1140

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacgcc atttgaccat   1200

tcaccacatt ggtgtgcacc tccaatctag aactagtgta agtatcaagg ttacaagaca   1260

ggtttaagga gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg   1320

ataggcacct attggtctta ctgacatcca ctttgccttt ctctccacag actagtggat   1380

ctcgagatga agcggagaga gctggagaag aaactgagga aagtgcgcgt gacacctcaa   1440

caggacaagt actataccat cggcaacctg cagtgggcca tccgcatgat caacctgatg   1500

ggcatcaagt gcgtgtgcga cgaggaatgc agcgccgctg aggtcgccct gatcatcacc   1560

cagtttagcg ccctcgacct ggagaactcc cctatccgcg gcaaggaaga ggtggccatc   1620

aagaataccc tgaaggtgtt ttggagcctg ctggccggat acaagcctga gagcaccgag   1680

accgccctgg gatactggga agccttcacc tacagagaga gggaagctag agccgacaag   1740

gagggagaga tcaagagcat ctaccctagc ctgacccaga acacccagaa caagaaacag   1800

accagcaatc agacaaacac ccagagcctg cccgctatca ccacacagga tggcacccct   1860

cgcttcgacc ccgacctgat gaagcagctg aagatctggt ccgatgccac agagcgcaat   1920

ggagtggacc tgcatgccgt gaacatcctg ggagtgatca cagccaacct ggtgcaagaa   1980

gagatcaagc tcctgctgaa tagcacaccc aagtggcgcc tggacgtgca gctgatcgag   2040

agcaaagtga gagagaagga gaacgcccac cgcacctgga agcagcatca ccctgaggct   2100

cccaagacag acgagatcat tggaaaggga ctgagctccg ccgagcaggc taccctgatc   2160

agcgtggagt gcagagagac cttccgccag tgggtgctgc aggctgccat ggaggtcgcc   2220

caggctaagc acgccacacc cggacctatc aacatccatc aaggccctaa ggaaccctac   2280

accgacttca tcaaccgcct ggtggctgcc ctggaaggaa tggccgctcc cgagaccaca   2340

aaggagtacc tcctgcagca cctgagcatc gaccacgcca acgaggactg tcagtccatc   2400

ctgcgccctc tgggacccaa cacacctatg gagaagaaac tggaggcctg tcgcgtggtg   2460

ggaagccaga agagcaagat gcagttcctg gtggccgcta tgaaggaaat ggggatccag   2520

tctcctattc cagccgtgct gcctcacaca cccgaagcct acgcctccca aacctcaggg   2580

cccgaggatg gtaggagatg ttacggatgt gggaagacag gacatttgaa gaggaattgt   2640

aaacagcaaa aatgctacca ttgtggcaaa cctggccacc aagcaagaaa ctgcaggtca   2700

aaaaacggga agtgctcctc tgccccttat gggcagagga gccaaccaca gaacaatttt   2760

caccagagca acatgagttc tgtgacccca tctgcacccc ctcttatatt agattagaca   2820

aacagccttt tataaaggtg ttcattggcg gccgctgggt gaagggactg gtggactcgg   2880

gcgctgacga ggtggtgctg aagaacatcc actgggaccg catcaaaggc taccctggaa   2940

cacccatcaa gcagatcggc gtgaacggcg tgaacgtggc taagcgcaaa acacatgtgg   3000

agtggagatt caaagacaag accggcatca ttgacgtcct cttcagcgac acacctgtga   3060

acctgtttgg cagaagcctg ctcagatcca tcgtgacctg ctttaccctg ctggtgcaca   3120

ccgagaagat cgagccactg cctgtgaagg tgcgcggccc tggacctaag gtgccacaat   3180

ggcccctgac caaggagaaa taccaggccc tgaaggagat cgtgaaggac ctgctggccg   3240

agggaaagat cagcgaagct gcctgggaca acccttacaa cacacccgtg ttcgtgatca   3300

agaagaaagg caccggccgc tggcgcatgc tgatggactt ccgcgagctg aataagatca   3360

ccgtgaaagg ccaagagttc agcacaggac tcccttatcc acccggcatc aaggagtgtg   3420

agcacctgac cgccatcgac atcaaggacg cctacttcac catccctctg cacgaggact   3480

tcagaccctt cacagccttc agcgtggtcc cagtgaaccg cgagggcccc atcgagcgct   3540

tccagtggaa cgtcctgcct caaggctggg tgtgctcccc tgccatctac cagaccacaa   3600

cccagaagat cattgagaac atcaagaaga gccatcccga cgtgatgctg tatcagtaca   3660

tggatgacct cctgattggc agcaatcgcg atgaccacaa gcagatcgtg caggagatca   3720

gagacaagct gggcagctat ggcttcaaga cacccgacga gaaagtgcag gaagagcgcg   3780

tgaagtggat cggcttcgag ctgacaccta agaaatggag attccagcct aggcaactga   3840

agatcaagaa cccactgacc gtgaacgaac tccagcagct ggtcggcaac tgtgtgtggg   3900

tgcagcccga ggtgaagatc cctctgtacc cactgaccga tctgctccgc gacaagacca   3960

acctgcagga aaagatccag ctgacacccg aggccatcaa gtgcgtggaa gagttcaacc   4020

tgaagctgaa agatcccgag tggaaggaca gaattcgcga aggagccgag ctggtgatca   4080

agatccaaat ggtccctcgc ggcatcgtgt tcgacctgct gcaagacggc aatcctatct   4140

ggggaggcgt gaaaggactg aactacgacc acagcaacaa gatcaagaag atcctgcgca   4200

ccatgaacga gctgaaccgc accgtggtga tcatgaccgg acgcgaagct agctttctcc   4260

tgcctggatc cagcgaggat tgggaggccg ccctgcagaa ggaagagagc ctgacccaaa   4320

tctttcccgt gaagttctac cgccatagct gtagatggac aagcatctgt ggacccgtcc   4380

gcgagaacct gaccacctac tataccgacg gcgggaagaa aggaaagaca gctgccgcag   4440

tgtactggtg tgaaggaaga actaagagca aagtgttccc tggaaccaat caacaggctg   4500

agctgaaggc aatctgcatg gctctgctgg acggacctcc caagatgaac atcatcaccg   4560

acagccgcta cgcttatgag ggcatgagag aggaacctga gacctgggct cgcgagggca   4620

tctggctgga gattgcaaag atcctgccat tcaagcaata cgtcggagtg ggctgggtcc   4680

ctgctcacaa aggcattgga ggcaataccg aggctgacga aggagtgaag aaagccctgg   4740

agcaaatggc accatgttcc cctcccgagg ctatcctgct caaacctggc gagaagcaaa   4800

acctggagac cggcatctac atgcaaggcc tgagacctca gagcttcctg ccccgcgctg   4860

acctccctgt cgcaatcact ggcaccatgg tggactccga gctgcagctc caactgctga   4920

acatcggcac cgagcacatt cgcatccaga aggacgaggt gttcatgaca tgcttcctgg   4980

agaacatccc tagcgccacc gaagaccacg agagatggca cacatcccca gacatcctgg   5040

tccgccagtt ccacctgccc aagcgcatcg ccaaggagat cgtcgcccgc tgccaggagt   5100

gcaagagaac cacaacctcc ccagtgcgcg gcaccaaccc tagaggacgc ttcctgtggc   5160

agatggacaa cacacactgg aacaaaacca tcatttgggt cgcagtggag actaacagcg   5220

gactggtgga ggctcaggtg attcccgaag agaccgcact gcaagtggcc ctgtgtatcc   5280

tccagctgat ccaacgctac accgtcctgc acctgcacag cgacaacgga ccctgcttca   5340

cagctcaccg catcgagaac ctgtgcaagt acctgggcat caccaagaca accggcattc   5400

cctacaatcc tcagagccaa ggagtcgtgg aaagagccca tcgcgacctg aaggacagac   5460

tggctgccta tcaaggcgac tgcgagaccg tggaagctgc actgagcctc gccctggtca   5520

gcctgaacaa gaagagagga ggcatcggcg gacacacacc ctacgagatc tatctggaga   5580

gcgagcacac caagtatcag gaccaactgg agcagcaatt cagcaagcag aagatcgaga   5640

aatggtgcta cgtccgcaac agacgcaagg agtggaaggg cccttacaag gtgctgtggg   5700

atggcgacgg agctgcagtg atcgaggaag agggcaagac cgctctgtat ccccaccggc   5760

acatgcgctt catcccacct cccgacagcg atatccagga cggctccagc tgatctagag   5820

tcgcccttta agctgcaata aacaatcatt attttcattg gatctgtgtg ttggtttttt   5880

gtgtgggctt gggggagggg gaggccagaa tgactccaag agctacagga aggcaggtca   5940

gagaccccac tggacaaaca gtggctggac tctgcaccat aacacacaat caacagggga   6000

gtgagctgga tcgagctggg gggatcctct aggatccccc gggctgcagg aattcgatat   6060

caagcttatc gataccgtcg acctcgaggg ggggcccggt accacatgtg agcaaaaggc   6120

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc   6180

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga   6240

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc   6300

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat   6360

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg   6420

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc   6480

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga   6540

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact   6600

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt   6660

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag   6720

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg   6780

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa   6840

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata   6900

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg   6960

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata   7020

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg   7080

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct   7140

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt   7200

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc   7260

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga   7320

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt   7380

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc   7440

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa   7500

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca   7560

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca   7620

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct   7680

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc   7740

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa   7800

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt   7860

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc ac           7912


<210> 20
<211> 4026
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 20
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg    540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg    600

taaaacgacg gccagtgagc gcgcgagctc caccgcggtg gcggccgctc tagaactctc    660

agtacaatct gctctgatgc cgcatagtta agccagtatc tgctccctgc ttgtgtgttg    720

gaggtcgctg agtagtgcgc gagcaaaatt taagctacaa caaggcaagg cttgaccgac    780

aattgcatga agaatctgct tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc    840

agatatacgc gtatctgagg ggactagggt gtgtttaggc gaaaagcggg gcttcggttg    900

tacgcggtta ggagtcccct caggatatag tagtttcgct tttgcatagg gagggggaaa    960

tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg   1020

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc   1080

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattcc   1140

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacgcc atttgaccat   1200

tcaccacatt ggtgtgcacc tccaatctag aactagtgta agtatcaagg ttacaagaca   1260

ggtttaagga gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg   1320

ataggcacct attggtctta ctgacatcca ctttgccttt ctctccacag actagtggat   1380

cgatccgcca ccatggacca ggacctggac agagctgaga gaggcgagag aggcggcgga   1440

agcgaggaac tgctgcagga agagatcaac gagggacggc tgacagctag agaggccctg   1500

cagacctgga tcaacaatga tagccctcgg tacgtgaaga aactgagaca gggacagccc   1560

gaactgccca ccagccctgg aggcggaggc ggaagaggac acagagctag gaagctgcct   1620

ggcgagcgga gacctggatt ctggaagagc ctgcgggagc tggtggagca gaacagacgg   1680

aagcaggaga gacggctgag cggactggac agacggattc agcagctgga ggacctggtg   1740

agacacatga gcctgggcag ccctgatcct agcacaccta gcgccagcgt cctgtccgtg   1800

aatcctcccg ctcagacacc tctgggacac ctgccaccta gaagctactt caagctgaaa   1860

cgggtggact gtggcgctgg ctgggacctg agaaccacag ctgctcccgg cctgcctatc   1920

tgcgagctgg actggattca gggcaccaag tgaggatcga tcccccgggc tgcaggaatt   1980

cgatatcaag cttatcgata ccgtcgacct cgagaataaa caatcattat tttcattgga   2040

tctgtgtgtt ggttttttgt gtgggcttgg gggaggggga ggccagaatg actccaagag   2100

ctacaggaag gcaggtcaga gaccccactg gacaaacagt ggctggactc tgcaccataa   2160

cacacaatca acaggggagt gagctggatc gagctgctcg agggggggcc cggtaccaca   2220

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt   2280

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc   2340

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct   2400

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg   2460

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca   2520

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact   2580

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta   2640

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta   2700

actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct   2760

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt   2820

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga   2880

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca   2940

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat   3000

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg   3060

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt   3120

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag   3180

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc   3240

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag   3300

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca   3360

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa   3420

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga   3480

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata   3540

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca   3600

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg   3660

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg   3720

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg   3780

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag   3840

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac   3900

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca   3960

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag   4020

tgccac                                                              4026


<210> 21
<211> 5007
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 21
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg    540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg    600

taaaacgacg gccagtgagc gcgcgagctc caccgcggtg gcggccgctc tagaactctc    660

agtacaatct gctctgatgc cgcatagtta agccagtatc tgctccctgc ttgtgtgttg    720

gaggtcgctg agtagtgcgc gagcaaaatt taagctacaa caaggcaagg cttgaccgac    780

aattgcatga agaatctgct tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc    840

agatatacgc gtatctgagg ggactagggt gtgtttaggc gaaaagcggg gcttcggttg    900

tacgcggtta ggagtcccct caggatatag tagtttcgct tttgcatagg gagggggaaa    960

tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg   1020

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc   1080

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattcc   1140

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacgcc atttgaccat   1200

tcaccacatt ggtgtgcacc tccaatctag aactagtgta agtatcaagg ttacaagaca   1260

ggtttaagga gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg   1320

ataggcacct attggtctta ctgacatcca ctttgccttt ctctccacag actagtggat   1380

cagcttgcca ccatggtgtc cgccatcgtg ctgtacgtgc tgctggccgc tgccgcacac   1440

agcgccttcg ccgccgagca ctgcaacgcc cagatgaaaa ccggccccta caagatcaag   1500

aacctggaca tcaccccccc caaggagacc ctgcagaagg acgtggagat caccatcgtg   1560

gagaccgact acaacgagaa cgtgatcatc ggctacaagg gctactacca ggcctacgcc   1620

tacaacggcg gcagcctgga ccccaacacc agagtggagg agaccatgaa aaccctgaat   1680

gtgggcaagg aagatctgct gatgtggagc atcaggcagc agtgcgaagt gggcgaggag   1740

ctgatcgaca gatggggcag cgacagcgac gactgcttca gagacaacga gggcagaggc   1800

cagtgggtga agggcaagga gctggtgaag cggcagaaca acaaccactt cgcccaccac   1860

acctgcaaca agagctggag atgcggcatc agcaccagca agatgtacag ccggctggag   1920

tgccaggatg acaccgatga gtgccaggtg tacatcctgg acgccgaggg caaccctatc   1980

aacgtgaccg tggacaccgt gctgcacaga gatggcgtgt ccatgatcct gaagcagaag   2040

agcaccttca ccaccaggca gatcaaggcc gcctgcctgc tgatcaagga cgacaagaac   2100

aaccccgaga gcgtgaccag agagcactgc ctgatcgaca acgacatcta cgacctgagc   2160

aagaacacct ggaactgcaa gttcaaccgg tgcatcaagc ggaaagtgga gcacagagtg   2220

aagaagagac cccccacctg gaggcacaat gtgcgggcca agtacaccga gggcgatacc   2280

gccaccaagg gcgacctgat gcacatccag gaagaactga tgtacgagaa cgacctgctg   2340

aagatgaaca tcgagctgat gcacgcccac atcaacaagc tgaacaacat gctgcacgac   2400

ctgatcgtgt ccgtggccaa agtggacgag aggctgatcg gcaacctgat gaacaacagc   2460

gtgtccagca ccttcctgag cgacgacacc ttcctgctga tgccctgcac caacccccct   2520

gcccacacca gcaactgcta caacaacagc atctacaagg agggccggtg ggtggccaac   2580

accgacagca gccagtgcat cgacttctcc aactataagg agctggccat cgacgacgat   2640

gtggagttct ggatccccac catcggcaac accacctacc acgacagctg gaaggacgcc   2700

agcggctgga gcttcatcgc ccagcagaag tccaacctga tcaccaccat ggagaacacc   2760

aagttcggcg gagtgggcac cagcctgagc gatatcacca gcatggccga gggcgagctg   2820

gccgccaagc tgaccagctt catgttcggc cacgtggtga acttcgtgat catcctgatc   2880

gtgatcctgt tcctgtactg catgatccgg aaccggaacc ggcagtactg atagtctagg   2940

atcccccggg ctgcaggaat tcgatatcaa gcttatcgat accgtcgacc tcgagaataa   3000

acaatcatta ttttcattgg atctgtgtgt tggttttttg tgtgggcttg ggggaggggg   3060

aggccagaat gactccaaga gctacaggaa ggcaggtcag agaccccact ggacaaacag   3120

tggctggact ctgcaccata acacacaatc aacaggggag tgagctggat cgagctgctc   3180

gagggggggc ccggtaccac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa   3240

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc   3300

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc   3360

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg   3420

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt   3480

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc   3540

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc   3600

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag   3660

agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg   3720

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa   3780

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag   3840

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact   3900

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa   3960

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt   4020

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag   4080

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca   4140

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc   4200

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt   4260

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg   4320

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca   4380

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg   4440

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca   4500

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg   4560

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct   4620

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca   4680

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca   4740

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg   4800

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac   4860

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt   4920

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc   4980

cgcgcacatt tccccgaaaa gtgccac                                       5007


<210> 22
<211> 6329
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 22
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg    540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg    600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tggagctcca    660

ccgcggtggc ggccgctcta gaactagtgg atcccccggg atcccgtagt tattaatagt    720

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta    780

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga    840

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt    900

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt ccgcccccta    960

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg   1020

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt   1080

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc   1140

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat   1200

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct   1260

atataaacca tatcttcact ctgtacttca gctcgtgtag ctcattagct ccgagctccc   1320

caacctacag cctgagaggc actggctcgg ttgggtagcc agcctttcgg gtaataaagg   1380

cttgttggca ttcggcatct acccgtgcct cctgtcttgt cttactcgag cgaacccaca   1440

actccgtcct gctgagctca cagctcgcgg ggcggtgaag aacacccaac agttggcgcc   1500

caacgtgggg ctgagtaaga gagactcggc tcgagtaaaa gaagacccag ctcgaacgag   1560

aagactccgg acaggtgagt agttgcgtgt tttccccggg gtgaagagaa gggagttaga   1620

aaagaagctt cgtaaggtta gggtgacacc ccaacaggat aaatattata ctatagggaa   1680

tcttcaatgg gccattagaa tcacgtgatg catcgataaa taaaaaaaga gggggaatag   1740

ggggccatac accatatgaa atatacctag aatcagaaca taccaaatac caagaccaac   1800

tagaacaaca attttcaaaa caaaaaattg aaaagtggtg ttacgtaagg aacagaagaa   1860

aggaatggaa aggaccctac aaagtgttgt gggacggaga cggggcagca gtaatagagg   1920

agaattcgtg gattcttgta aaggtcccca gctatgggtt tgtggtagta aatgacacag   1980

atacaccacc atccctccgc atccgaaagc ctcgagcagt cggactagca atattcctgc   2040

ttgtgctggc tatcatggcc atcacatcct ccttggtggc agctacaacg ctcgtgaacc   2100

agcacacgac ggctaaggtt gtggagaggg ttgtgcaaaa tgtgtcatat attgctcaaa   2160

cccaggacca attcacccac ctgttcagga atataaacaa cagattaaat gtcctacacc   2220

atagagtttc atacttggag tgtacactta atgggaatga aagaccccac ctgtaggttt   2280

ggcaagctag gatcaaggtt aggaacagag agacagcaga atatgggcca aacaggatat   2340

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agttggaaca gcagaatatg   2400

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg   2460

gtccccagat gcggtcccgc cctcagcagt ttctagagaa ccatcagatg tttccagggt   2520

gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag ttcgcttctc   2580

gcttctgttc gcgcgcttct gctccccgag ctctatataa gcagagctcg tttagtgaac   2640

cgtcagatcg cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgactc   2700

tagaggatcc accggtcgcc acttaaggcc tgcagctagc accggttgta caagtcaagc   2760

ggccaaccct ccctagatct gttaatcaac ctctggatta caaaatttgt gaaagattga   2820

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt   2880

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt   2940

tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg   3000

tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg   3060

ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc   3120

gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaagc   3180

tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct   3240

tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg   3300

ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg   3360

ccgcctcccc gcctgtttcg ccttctagga aactcctttg ggacatcttc cgccacgctc   3420

ctattttaaa cttaaaaggg tggactgtgg ggcagggtgg gacctcagga caacagcagc   3480

ccccggactt cccatatgtg tttatttgtg aaatttgtga tgctattgct ttatttgtaa   3540

tctgtacttc agctcgtgta gctcattagc tccgagctcc ccaacctaca gcctgagagg   3600

cactggctcg gttgggtagc cagcctttcg ggtaataaag gcttgttggc attcggcatc   3660

tacccgtgcc tcctgtcttg tcttactcga gcgaacccac aactccgtcc tgctgagctc   3720

acagctcgcg gggcggtgaa gaacacccaa cagatatata ctgtcaacat cccatttggt   3780

agcttatgtt ctagacaaga ttctcaacaa attcttcccc ctgaatgttt atttaaaaaa   3840

aaaaaacaac tactagggct ctgtgcatat gtaagtgaga tccttattag caggagaaca   3900

gcaataagat attattacat tacaatatta tatcctaggg tattataatg caaggccatt   3960

atcacatact tggctaacag ggtccatact gttgtaatgt attaaaacca gactgagtaa   4020

taaaattgac aacaatataa tcatcatctt tgttataggt gggggcattt ttcagatgag   4080

gtctcagagc acctgccaag catggacctc gagggggggc ccggtaccca gcttttgttc   4140

cctttagtga gggttaattg cgcgcttggc gtaatcatgg tcatagctgt ttcctgtgtg   4200

aaattgttat ccgctcacaa ttccacacaa catacgagcc gggagcataa agtgtaaagc   4260

ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt   4320

ccagtcggga aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg   4380

cggtttgcgt attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt   4440

tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc   4500

aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa   4560

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa   4620

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc   4680

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc   4740

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag   4800

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga   4860

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc   4920

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac   4980

agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg   5040

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca   5100

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa   5160

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa   5220

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt   5280

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag   5340

ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat   5400

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc   5460

cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa   5520

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca   5580

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa   5640

cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt   5700

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc   5760

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact   5820

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc   5880

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg   5940

ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct   6000

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc   6060

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag   6120

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac   6180

acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg   6240

ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt   6300

tccgcgcaca tttccccgaa aagtgccac                                     6329


<210> 23
<211> 7068
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      polynucleotide 

<400> 23
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg    540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg    600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tggagctcca    660

ccgcggtggc ggccgctcta gaactagtgg atcccccggc atcccgtagt tattaatagt    720

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta    780

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga    840

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt    900

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt ccgcccccta    960

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg   1020

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt   1080

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc   1140

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat   1200

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct   1260

atataaacca tatcttcact ctgtacttca gctcgtgtag ctcattagct ccgagctccc   1320

caacctacag cctgagaggc actggctcgg ttgggtagcc agcctttcgg gtaataaagg   1380

cttgttggca ttcggcatct acccgtgcct cctgtcttgt cttactcgag cgaacccaca   1440

actccgtcct gctgagctca cagctcgcgg ggcggtgaag aacacccaac agttggcgcc   1500

caacgtgggg ctgagtaaga gagactcggc tcgagtaaaa gaagacccag ctcgaacgag   1560

aagactccgg acaggtgagt agttgcgtgt tttccccggg gtgaagagaa gggagttaga   1620

aaagaagctt cgtaaggtta gggtgacacc ccaacaggat aaatattata ctatagggaa   1680

tcttcaatgg gccattagaa tcacgtgatg catcgataaa taaaaaaaga gggggaatag   1740

ggggccatac accatatgaa atatacctag aatcagaaca taccaaatac caagaccaac   1800

tagaacaaca attttcaaaa caaaaaattg aaaagtggtg ttacgtaagg aacagaagaa   1860

aggaatggaa aggaccctac aaagtgttgt gggacggaga cggggcagca gtaatagagg   1920

agaattcgtg gattcttgta aaggtcccca gctatgggtt tgtggtagta aatgacacag   1980

atacaccacc atccctccgc atccgaaagc ctcgagcagt cggactagca atattcctgc   2040

ttgtgctggc tatcatggcc atcacatcct ccttggtggc agctacaacg ctcgtgaacc   2100

agcacacgac ggctaaggtt gtggagaggg ttgtgcaaaa tgtgtcatat attgctcaaa   2160

cccaggacca attcacccac ctgttcagga atataaacaa cagattaaat gtcctacacc   2220

atagagtttc atacttggag tgtacactta atgggaatga aagaccccac ctgtaggttt   2280

ggcaagctag gatcaaggtt aggaacagag agacagcaga atatgggcca aacaggatat   2340

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agttggaaca gcagaatatg   2400

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg   2460

gtccccagat gcggtcccgc cctcagcagt ttctagagaa ccatcagatg tttccagggt   2520

gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag ttcgcttctc   2580

gcttctgttc gcgcgcttct gctccccgag ctctatataa gcagagctcg tttagtgaac   2640

cgtcagatcg cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgactc   2700

tagaggatcc accggtcgcc acttaaggcc cggtcgccac catggtgagc aagggcgagg   2760

agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca   2820

agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt   2880

tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc accctgacct   2940

acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac ttcttcaagt   3000

ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac gacggcaact   3060

acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga   3120

agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca   3180

acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag gtgaacttca   3240

agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac cagcagaaca   3300

cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc acccagtccg   3360

ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag ttcgtgaccg   3420

ccgccgggat cactctcggc atggacgagc tgtacaagta aagtcgacct gcagctagca   3480

ccggttgtac aagtcaagcg gccaaccctc cctagatctg ttaatcaacc tctggattac   3540

aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga   3600

tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc   3660

tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa   3720

cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc   3780

acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc   3840

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc   3900

gtggtgttgt cggggaagct gacgtccttt ccatggctgc tcgcctgtgt tgccacctgg   3960

attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct   4020

tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg   4080

agtcggatct ccctttgggc cgcctccccg cctgtttcgc cttctaggaa actcctttgg   4140

gacatcttcc gccacgctcc tattttaaac ttaaaagggt ggactgtggg gcagggtggg   4200

acctcaggac aacagcagcc cccggacttc ccatatgtgt ttatttgtga aatttgtgat   4260

gctattgctt tatttgtaat ctgtacttca gctcgtgtag ctcattagct ccgagctccc   4320

caacctacag cctgagaggc actggctcgg ttgggtagcc agcctttcgg gtaataaagg   4380

cttgttggca ttcggcatct acccgtgcct cctgtcttgt cttactcgag cgaacccaca   4440

actccgtcct gctgagctca cagctcgcgg ggcggtgaag aacacccaac agatatatac   4500

tgtcaacatc ccatttggta gcttatgttc tagacaagat tctcaacaaa ttcttccccc   4560

tgaatgttta tttaaaaaaa aaaaacaact actagggctc tgtgcatatg taagtgagat   4620

ccttattagc aggagaacag caataagata ttattacatt acaatattat atcctagggt   4680

attataatgc aaggccatta tcacatactt ggctaacagg gtccatactg ttgtaatgta   4740

ttaaaaccag actgagtaat aaaattgaca acaatataat catcatcttt gttataggtg   4800

ggggcatttt tcagatgagg tctcagagca cctgccaagc atggacctcg agggggggcc   4860

cggtacccag cttttgttcc ctttagtgag ggttaattgc gcgcttggcg taatcatggt   4920

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg   4980

ggagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt   5040

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg   5100

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg   5160

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa   5220

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc   5280

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc   5340

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat   5400

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc   5460

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct   5520

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg   5580

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc   5640

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga   5700

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa   5760

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta   5820

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc   5880

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg   5940

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga   6000

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg   6060

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct   6120

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg   6180

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc   6240

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa   6300

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc   6360

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt   6420

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc   6480

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt   6540

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc   6600

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt   6660

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata   6720

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga   6780

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag   6840

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa   6900

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt   6960

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga   7020

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccac                7068


<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 24
acaccaccat ccctccgcat ccga                                            24


<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 25
tgggtttgtg gtagtaaatg acac                                            24


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 26
tggttcacga gcgttgtagc                                                 20


<210> 27
<211> 253
<212> PRT
<213> Homo sapiens

<400> 27
Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250                 


