                         SEQUENCE LISTING



<110>  Invitrogen Corporation

       KUDLICKI, Wieslaw

       FLETCHER, Julia

       KATZEN, Federico

	BEECHEM, Joseph

	WANG, Lilin

	

 

<120>  IN VITRO PROTEIN SYNTHESIS SYSTEMS FOR MEMBRANE PROTEINS 



<130>  IVGN 498.PRO6



<150>  60/721,339

<151>  2005-09-27



<150>  60/721,339

<151>  2005-09-27



<150>  60/724,213

<151>  2005-10-05



<150>  60/815,750

<151>  2006-06-21



<150>  60/815,695

<151>  2006-06-21



<160>  42    



<170>  PatentIn version 3.3



<210>  1

<211>  267

<212>  PRT

<213>  Human



<400>  1



Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 

1               5                   10                  15      





Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 

            20                  25                  30          





Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 

        35                  40                  45              





Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 

    50                  55                  60                  





Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 

65                  70                  75                  80  





Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 

                85                  90                  95      





Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 

            100                 105                 110         





Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 

        115                 120                 125             





Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 

    130                 135                 140                 





Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 

145                 150                 155                 160 





Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 

                165                 170                 175     





Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 

            180                 185                 190         





Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 

        195                 200                 205             





Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 

    210                 215                 220                 





Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 

225                 230                 235                 240 





Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 

                245                 250                 255     





Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

            260                 265         





<210>  2

<211>  250

<212>  PRT

<213>  Human



<400>  2



Met Ala His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp Asp 

1               5                   10                  15      





Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 

            20                  25                  30          





Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 

        35                  40                  45              





Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 

    50                  55                  60                  





Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 

65                  70                  75                  80  





Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 

                85                  90                  95      





Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 

            100                 105                 110         





Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 

        115                 120                 125             





Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 

    130                 135                 140                 





Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 

145                 150                 155                 160 





Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 

                165                 170                 175     





Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 

            180                 185                 190         





Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 

        195                 200                 205             





Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 

    210                 215                 220                 





Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 

225                 230                 235                 240 





Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

                245                 250 





<210>  3

<211>  100

<212>  PRT

<213>  Human



<400>  3



Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 

1               5                   10                  15      





Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 

            20                  25                  30          





Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 

        35                  40                  45              





Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 

    50                  55                  60                  





Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 

65                  70                  75                  80  





Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 

                85                  90                  95      





Pro Ala Thr Gln 

            100 





<210>  4

<211>  396

<212>  PRT

<213>  Human



<400>  4



Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 

1               5                   10                  15      





Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 

            20                  25                  30          





Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 

        35                  40                  45              





Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 

    50                  55                  60                  





Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 

65                  70                  75                  80  





Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 

                85                  90                  95      





Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 

            100                 105                 110         





Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 

        115                 120                 125             





Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 

    130                 135                 140                 





Gln Val Asn Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Asp Pro Leu 

145                 150                 155                 160 





Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 

                165                 170                 175     





Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 

            180                 185                 190         





Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 

        195                 200                 205             





Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 

    210                 215                 220                 





Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 

225                 230                 235                 240 





Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 

                245                 250                 255     





Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 

            260                 265                 270         





Asp Val Arg Gly Asn Leu Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 

        275                 280                 285             





Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 

    290                 295                 300                 





Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 

305                 310                 315                 320 





Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 

                325                 330                 335     





Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 

            340                 345                 350         





Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 

        355                 360                 365             





Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 

    370                 375                 380                 





Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 

385                 390                 395     





<210>  5

<211>  366

<212>  PRT

<213>  Human



<400>  5



Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 

1               5                   10                  15      





Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 

            20                  25                  30          





Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys 

        35                  40                  45              





Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 

    50                  55                  60                  





Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser 

65                  70                  75                  80  





Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu 

                85                  90                  95      





Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 

            100                 105                 110         





Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln 

        115                 120                 125             





Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 

    130                 135                 140                 





Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala 

145                 150                 155                 160 





Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu 

                165                 170                 175     





Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His 

            180                 185                 190         





Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu 

        195                 200                 205             





Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu 

    210                 215                 220                 





Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys 

225                 230                 235                 240 





Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu 

                245                 250                 255     





Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro 

            260                 265                 270         





Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe 

        275                 280                 285             





Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp 

    290                 295                 300                 





Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly 

305                 310                 315                 320 





His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val 

                325                 330                 335     





Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr 

            340                 345                 350         





His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 

        355                 360                 365     





<210>  6

<211>  4563

<212>  PRT

<213>  Human



<400>  6



Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 

            20                  25                  30          





Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 

        35                  40                  45              





Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 

    50                  55                  60                  





Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 

65                  70                  75                  80  





Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 

                85                  90                  95      





Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 

            100                 105                 110         





Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 

        115                 120                 125             





Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 

    130                 135                 140                 





Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 

145                 150                 155                 160 





Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 

                165                 170                 175     





Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 

            180                 185                 190         





Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 

        195                 200                 205             





Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 

    210                 215                 220                 





Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 

225                 230                 235                 240 





Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 

                245                 250                 255     





Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 

            260                 265                 270         





Asn Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 

        275                 280                 285             





Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 

    290                 295                 300                 





Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 

305                 310                 315                 320 





Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 

                325                 330                 335     





Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 

            340                 345                 350         





Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 

        355                 360                 365             





Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 

    370                 375                 380                 





Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 

385                 390                 395                 400 





Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 

                405                 410                 415     





Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 

            420                 425                 430         





Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 

        435                 440                 445             





Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 

    450                 455                 460                 





Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 

465                 470                 475                 480 





Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 

                485                 490                 495     





Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 

            500                 505                 510         





Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 

        515                 520                 525             





Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 

    530                 535                 540                 





Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 

545                 550                 555                 560 





Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 

                565                 570                 575     





Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 

            580                 585                 590         





Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 

        595                 600                 605             





Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 

    610                 615                 620                 





Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 

625                 630                 635                 640 





Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 

                645                 650                 655     





Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 

            660                 665                 670         





Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 

        675                 680                 685             





Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 

    690                 695                 700                 





Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 

705                 710                 715                 720 





Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 

                725                 730                 735     





His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 

            740                 745                 750         





Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 

        755                 760                 765             





Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 

    770                 775                 780                 





Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 

785                 790                 795                 800 





Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 

                805                 810                 815     





Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 

            820                 825                 830         





Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 

        835                 840                 845             





Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 

    850                 855                 860                 





Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 

865                 870                 875                 880 





Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 

                885                 890                 895     





Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 

            900                 905                 910         





Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 

        915                 920                 925             





Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 

    930                 935                 940                 





Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 

945                 950                 955                 960 





Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 

                965                 970                 975     





Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 

            980                 985                 990         





Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 

        995                 1000                 1005             





Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 

    1010                 1015                 1020             





Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 

    1025                 1030                 1035             





Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 

    1040                 1045                 1050             





Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 

    1055                 1060                 1065             





Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 

    1070                 1075                 1080             





Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 

    1085                 1090                 1095             





Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 

    1100                 1105                 1110             





Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 

    1115                 1120                 1125             





Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 

    1130                 1135                 1140             





Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 

    1145                 1150                 1155             





Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 

    1160                 1165                 1170             





Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 

    1175                 1180                 1185             





Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 

    1190                 1195                 1200             





Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Glu 

    1205                 1210                 1215             





Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 

    1220                 1225                 1230             





Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 

    1235                 1240                 1245             





Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 

    1250                 1255                 1260             





Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 

    1265                 1270                 1275             





Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 

    1280                 1285                 1290             





Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 

    1295                 1300                 1305             





Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 

    1310                 1315                 1320             





Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 

    1325                 1330                 1335             





Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 

    1340                 1345                 1350             





Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 

    1355                 1360                 1365             





Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 

    1370                 1375                 1380             





Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 

    1385                 1390                 1395             





Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 

    1400                 1405                 1410             





His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 

    1415                 1420                 1425             





Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 

    1430                 1435                 1440             





Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 

    1445                 1450                 1455             





Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 

    1460                 1465                 1470             





Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 

    1475                 1480                 1485             





Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 

    1490                 1495                 1500             





Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 

    1505                 1510                 1515             





Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 

    1520                 1525                 1530             





Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 

    1535                 1540                 1545             





Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 

    1550                 1555                 1560             





Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 

    1565                 1570                 1575             





Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 

    1580                 1585                 1590             





Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 

    1595                 1600                 1605             





Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 

    1610                 1615                 1620             





Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 

    1625                 1630                 1635             





Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 

    1640                 1645                 1650             





Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 

    1655                 1660                 1665             





Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 

    1670                 1675                 1680             





Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 

    1685                 1690                 1695             





Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 

    1700                 1705                 1710             





Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 

    1715                 1720                 1725             





Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 

    1730                 1735                 1740             





Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 

    1745                 1750                 1755             





Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 

    1760                 1765                 1770             





Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 

    1775                 1780                 1785             





Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 

    1790                 1795                 1800             





Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 

    1805                 1810                 1815             





Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 

    1820                 1825                 1830             





Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 

    1835                 1840                 1845             





Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 

    1850                 1855                 1860             





Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 

    1865                 1870                 1875             





Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 

    1880                 1885                 1890             





Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 

    1895                 1900                 1905             





Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 

    1910                 1915                 1920             





Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 

    1925                 1930                 1935             





Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 

    1940                 1945                 1950             





Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 

    1955                 1960                 1965             





Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 

    1970                 1975                 1980             





Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 

    1985                 1990                 1995             





Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 

    2000                 2005                 2010             





Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 

    2015                 2020                 2025             





Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 

    2030                 2035                 2040             





Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 

    2045                 2050                 2055             





Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 

    2060                 2065                 2070             





Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 

    2075                 2080                 2085             





Ile Val  Val Val Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 

    2090                 2095                 2100             





Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 

    2105                 2110                 2115             





Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 

    2120                 2125                 2130             





Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 

    2135                 2140                 2145             





Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 

    2150                 2155                 2160             





Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 

    2165                 2170                 2175             





Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 

    2180                 2185                 2190             





Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 

    2195                 2200                 2205             





Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 

    2210                 2215                 2220             





Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 

    2225                 2230                 2235             





Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 

    2240                 2245                 2250             





Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 

    2255                 2260                 2265             





Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 

    2270                 2275                 2280             





Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 

    2285                 2290                 2295             





Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 

    2300                 2305                 2310             





Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 

    2315                 2320                 2325             





Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 

    2330                 2335                 2340             





Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 

    2345                 2350                 2355             





Asp Lys  Leu Val Glu Leu Thr  His Gln Tyr Lys Leu  Lys Glu Thr 

    2360                 2365                 2370             





Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 

    2375                 2380                 2385             





Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 

    2390                 2395                 2400             





Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 

    2405                 2410                 2415             





Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 

    2420                 2425                 2430             





Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 

    2435                 2440                 2445             





Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 

    2450                 2455                 2460             





Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 

    2465                 2470                 2475             





Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 

    2480                 2485                 2490             





Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 

    2495                 2500                 2505             





Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 

    2510                 2515                 2520             





Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 

    2525                 2530                 2535             





Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 

    2540                 2545                 2550             





Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 

    2555                 2560                 2565             





Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 

    2570                 2575                 2580             





Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 

    2585                 2590                 2595             





Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 

    2600                 2605                 2610             





Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 

    2615                 2620                 2625             





Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 

    2630                 2635                 2640             





Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 

    2645                 2650                 2655             





Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 

    2660                 2665                 2670             





Arg Thr  Ile Asp Gln Met Gln  Asn Ser Glu Leu Gln  Trp Pro Val 

    2675                 2680                 2685             





Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 

    2690                 2695                 2700             





Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 

    2705                 2710                 2715             





Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 

    2720                 2725                 2730             





Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 

    2735                 2740                 2745             





Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 

    2750                 2755                 2760             





Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 

    2765                 2770                 2775             





Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 

    2780                 2785                 2790             





Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 

    2795                 2800                 2805             





Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 

    2810                 2815                 2820             





Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 

    2825                 2830                 2835             





His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 

    2840                 2845                 2850             





Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 

    2855                 2860                 2865             





Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 

    2870                 2875                 2880             





Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 

    2885                 2890                 2895             





Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 

    2900                 2905                 2910             





Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 

    2915                 2920                 2925             





Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 

    2930                 2935                 2940             





Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 

    2945                 2950                 2955             





Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 

    2960                 2965                 2970             





Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 

    2975                 2980                 2985             





Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 

    2990                 2995                 3000             





Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 

    3005                 3010                 3015             





Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 

    3020                 3025                 3030             





Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 

    3035                 3040                 3045             





Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 

    3050                 3055                 3060             





Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 

    3065                 3070                 3075             





Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 

    3080                 3085                 3090             





Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 

    3095                 3100                 3105             





Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 

    3110                 3115                 3120             





Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 

    3125                 3130                 3135             





Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 

    3140                 3145                 3150             





Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 

    3155                 3160                 3165             





Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 

    3170                 3175                 3180             





His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 

    3185                 3190                 3195             





Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 

    3200                 3205                 3210             





Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 

    3215                 3220                 3225             





Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 

    3230                 3235                 3240             





Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 

    3245                 3250                 3255             





Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 

    3260                 3265                 3270             





Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 

    3275                 3280                 3285             





Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 

    3290                 3295                 3300             





Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 

    3305                 3310                 3315             





His Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 

    3320                 3325                 3330             





Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 

    3335                 3340                 3345             





Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 

    3350                 3355                 3360             





Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 

    3365                 3370                 3375             





Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 

    3380                 3385                 3390             





Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 

    3395                 3400                 3405             





Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 

    3410                 3415                 3420             





Ser Val  Ala Lys Thr Thr Lys  Ala Glu Ile Pro Ile  Leu Arg Met 

    3425                 3430                 3435             





Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 

    3440                 3445                 3450             





Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 

    3455                 3460                 3465             





Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 

    3470                 3475                 3480             





Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 

    3485                 3490                 3495             





Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 

    3500                 3505                 3510             





Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 

    3515                 3520                 3525             





Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 

    3530                 3535                 3540             





Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 

    3545                 3550                 3555             





Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 

    3560                 3565                 3570             





Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 

    3575                 3580                 3585             





Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 

    3590                 3595                 3600             





Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 

    3605                 3610                 3615             





Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 

    3620                 3625                 3630             





Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 

    3635                 3640                 3645             





Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 

    3650                 3655                 3660             





Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 

    3665                 3670                 3675             





Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 

    3680                 3685                 3690             





Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 

    3695                 3700                 3705             





Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 

    3710                 3715                 3720             





Lys Val  Leu Ala Asp Lys Phe  Ile Thr Pro Gly Leu  Lys Leu Asn 

    3725                 3730                 3735             





Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 

    3740                 3745                 3750             





Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 

    3755                 3760                 3765             





Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 

    3770                 3775                 3780             





Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 

    3785                 3790                 3795             





Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 

    3800                 3805                 3810             





Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 

    3815                 3820                 3825             





Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 

    3830                 3835                 3840             





Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 

    3845                 3850                 3855             





Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 

    3860                 3865                 3870             





Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 

    3875                 3880                 3885             





Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 

    3890                 3895                 3900             





Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 

    3905                 3910                 3915             





Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 

    3920                 3925                 3930             





His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 

    3935                 3940                 3945             





Leu Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 

    3950                 3955                 3960             





Phe Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 

    3965                 3970                 3975             





Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 

    3980                 3985                 3990             





Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 

    3995                 4000                 4005             





Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 

    4010                 4015                 4020             





Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 

    4025                 4030                 4035             





Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 

    4040                 4045                 4050             





Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 

    4055                 4060                 4065             





Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 

    4070                 4075                 4080             





Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 

    4085                 4090                 4095             





Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 

    4100                 4105                 4110             





Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 

    4115                 4120                 4125             





Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 

    4130                 4135                 4140             





Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 

    4145                 4150                 4155             





Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 

    4160                 4165                 4170             





Gly Leu  Val Arg Val Thr Gln  Lys Phe His Met Lys  Val Lys His 

    4175                 4180                 4185             





Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 

    4190                 4195                 4200             





Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 

    4205                 4210                 4215             





Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 

    4220                 4225                 4230             





Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 

    4235                 4240                 4245             





Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 

    4250                 4255                 4260             





Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 

    4265                 4270                 4275             





Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 

    4280                 4285                 4290             





Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 

    4295                 4300                 4305             





Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 

    4310                 4315                 4320             





Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Asn 

    4325                 4330                 4335             





Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 

    4340                 4345                 4350             





Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 

    4355                 4360                 4365             





Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 

    4370                 4375                 4380             





Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 

    4385                 4390                 4395             





Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 

    4400                 4405                 4410             





Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 

    4415                 4420                 4425             





Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 

    4430                 4435                 4440             





Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 

    4445                 4450                 4455             





Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 

    4460                 4465                 4470             





Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 

    4475                 4480                 4485             





Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 

    4490                 4495                 4500             





Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 

    4505                 4510                 4515             





Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 

    4520                 4525                 4530             





Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 

    4535                 4540                 4545             





Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 

    4550                 4555                 4560             





<210>  7

<211>  728

<212>  PRT

<213>  Human



<400>  7



Leu Asn Ala Glu Leu Gly Leu Ser Gly Ala Ser Met Lys Leu Thr Thr 

1               5                   10                  15      





Asn Gly Arg Phe Arg Glu His Asn Ala Lys Phe Ser Leu Asp Gly Lys 

            20                  25                  30          





Ala Ala Leu Thr Glu Leu Ser Leu Gly Ser Ala Tyr Gln Ala Met Ile 

        35                  40                  45              





Leu Gly Val Asp Ser Lys Asn Ile Phe Asn Phe Lys Val Ser Gln Glu 

    50                  55                  60                  





Gly Leu Lys Leu Ser Asn Asp Met Met Gly Ser Tyr Ala Glu Met Lys 

65                  70                  75                  80  





Phe Asp His Thr Asn Ser Leu Asn Ile Ala Gly Leu Ser Leu Asp Phe 

                85                  90                  95      





Ser Ser Lys Leu Asp Asn Ile Tyr Ser Ser Asp Lys Phe Tyr Lys Gln 

            100                 105                 110         





Thr Val Asn Leu Gln Leu Gln Pro Tyr Ser Leu Val Thr Thr Leu Asn 

        115                 120                 125             





Ser Asp Leu Lys Tyr Asn Ala Leu Asp Leu Thr Asn Asn Gly Lys Leu 

    130                 135                 140                 





Arg Leu Glu Pro Leu Lys Leu His Val Ala Gly Asn Leu Lys Gly Ala 

145                 150                 155                 160 





Tyr Gln Asn Asn Glu Ile Lys His Ile Tyr Ala Ile Ser Ser Ala Ala 

                165                 170                 175     





Leu Ser Ala Ser Tyr Lys Ala Asp Thr Val Ala Lys Val Gln Gly Val 

            180                 185                 190         





Glu Phe Ser His Arg Leu Asn Thr Asp Ile Ala Gly Leu Ala Ser Ala 

        195                 200                 205             





Ile Asp Met Ser Thr Asn Tyr Asn Ser Asp Ser Leu His Phe Ser Asn 

    210                 215                 220                 





Val Phe Arg Ser Val Met Ala Pro Phe Thr Met Thr Ile Asp Ala His 

225                 230                 235                 240 





Thr Asn Gly Asn Gly Lys Leu Ala Leu Trp Gly Glu His Thr Gly Gln 

                245                 250                 255     





Leu Tyr Ser Lys Phe Leu Leu Lys Ala Glu Pro Leu Ala Phe Thr Phe 

            260                 265                 270         





Ser His Asp Tyr Lys Gly Ser Thr Ser His His Leu Val Ser Arg Lys 

        275                 280                 285             





Ser Ile Ser Ala Ala Leu Glu His Lys Val Ser Ala Leu Leu Thr Pro 

    290                 295                 300                 





Ala Glu Gln Thr Gly Thr Trp Lys Leu Lys Thr Gln Phe Asn Asn Asn 

305                 310                 315                 320 





Glu Tyr Ser Gln Asp Leu Asp Ala Tyr Asn Thr Lys Asp Lys Ile Gly 

                325                 330                 335     





Val Glu Leu Thr Gly Arg Thr Leu Ala Asp Leu Thr Leu Leu Asp Ser 

            340                 345                 350         





Pro Ile Lys Val Pro Leu Leu Leu Ser Glu Pro Ile Asn Ile Ile Asp 

        355                 360                 365             





Ala Leu Glu Met Arg Asp Ala Val Glu Lys Pro Gln Glu Phe Thr Ile 

    370                 375                 380                 





Val Ala Phe Val Lys Tyr Asp Lys Asn Gln Asp Val His Ser Ile Asn 

385                 390                 395                 400 





Leu Pro Phe Phe Glu Thr Leu Gln Glu Tyr Phe Glu Arg Asn Arg Gln 

                405                 410                 415     





Thr Ile Ile Val Val Leu Glu Asn Val Gln Arg Asn Leu Lys His Ile 

            420                 425                 430         





Asn Ile Asp Gln Phe Val Arg Lys Tyr Arg Ala Ala Leu Gly Lys Leu 

        435                 440                 445             





Pro Gln Gln Ala Asn Asp Tyr Leu Asn Ser Phe Asn Trp Glu Arg Gln 

    450                 455                 460                 





Val Ser His Ala Lys Glu Lys Leu Thr Ala Leu Thr Lys Lys Tyr Arg 

465                 470                 475                 480 





Ile Thr Glu Asn Asp Ile Gln Ile Ala Leu Asp Asp Ala Lys Ile Asn 

                485                 490                 495     





Phe Asn Glu Lys Leu Ser Gln Leu Gln Thr Tyr Met Ile Gln Phe Asp 

            500                 505                 510         





Gln Tyr Ile Lys Asp Ser Tyr Asp Leu His Asp Leu Lys Ile Ala Ile 

        515                 520                 525             





Ala Asn Ile Ile Asp Glu Ile Ile Glu Lys Leu Lys Ser Leu Asp Glu 

    530                 535                 540                 





His Tyr His Ile Arg Val Asn Leu Val Lys Thr Ile His Asp Leu His 

545                 550                 555                 560 





Leu Phe Ile Glu Asn Ile Asp Phe Asn Lys Ser Gly Ser Ser Thr Ala 

                565                 570                 575     





Ser Trp Ile Gln Asn Val Asp Thr Lys Tyr Gln Ile Arg Ile Gln Ile 

            580                 585                 590         





Gln Glu Lys Leu Gln Gln Leu Lys Arg His Ile Gln Asn Ile Asp Ile 

        595                 600                 605             





Gln His Leu Ala Gly Lys Leu Lys Gln His Ile Glu Ala Ile Asp Val 

    610                 615                 620                 





Arg Val Leu Leu Asp Gln Leu Gly Thr Thr Ile Ser Phe Glu Arg Ile 

625                 630                 635                 640 





Asn Asp Val Leu Glu His Val Lys His Phe Val Ile Asn Pro Tyr Trp 

                645                 650                 655     





Asp Phe Glu Val Ala Glu Lys Ile Asn Ala Phe Arg Ala Lys Val His 

            660                 665                 670         





Glu Leu Ile Glu Arg Tyr Glu Val Asp Gln His Ile Gln Val Leu Met 

        675                 680                 685             





Asp Lys Leu Val Glu Leu Ala His Gln Tyr Lys Leu Lys Glu Thr Ile 

    690                 695                 700                 





Gln Lys Leu Ser Asn Val Leu Gln Gln Val Lys Ile Lys Asp Tyr Phe 

705                 710                 715                 720 





Glu Lys Leu Val Gly Phe Ile Asp 

                725             





<210>  8

<211>  83

<212>  PRT

<213>  Human



<400>  8



Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 

1               5                   10                  15      





Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 

            20                  25                  30          





Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 

        35                  40                  45              





Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 

    50                  55                  60                  





Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 

65                  70                  75                  80  





Ile Asp Ser 

            





<210>  9

<211>  101

<212>  PRT

<213>  Human



<400>  9



Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 

1               5                   10                  15      





Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 

            20                  25                  30          





Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 

        35                  40                  45              





Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 

    50                  55                  60                  





Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala 

65                  70                  75                  80  





Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val 

                85                  90                  95      





Leu Lys Gly Glu Glu 

            100     





<210>  10

<211>  99

<212>  PRT

<213>  Human



<400>  10



Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 

1               5                   10                  15      





Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 

            20                  25                  30          





Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 

        35                  40                  45              





Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 

    50                  55                  60                  





Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 

65                  70                  75                  80  





Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Ala Ser Ala 

                85                  90                  95      





Val Ala Ala 

            





<210>  11

<211>  189

<212>  PRT

<213>  Human



<400>  11



Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 

1               5                   10                  15      





Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 

            20                  25                  30          





Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 

        35                  40                  45              





Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 

    50                  55                  60                  





Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 

65                  70                  75                  80  





Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 

                85                  90                  95      





Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 

            100                 105                 110         





Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 

        115                 120                 125             





Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 

    130                 135                 140                 





Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 

145                 150                 155                 160 





Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 

                165                 170                 175     





Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 

            180                 185                 





<210>  12

<211>  98

<212>  PRT

<213>  Human



<400>  12



Gly Glu Ala Thr Pro Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val 

1               5                   10                  15      





Lys Phe Ser Trp Phe Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr 

            20                  25                  30          





Asp Tyr Glu Asn Tyr Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln 

        35                  40                  45              





Leu Phe His Val Asp Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu 

    50                  55                  60                  





Pro Pro Glu Thr Val Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn 

65                  70                  75                  80  





Ile Asp Val Lys Lys Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys 

                85                  90                  95      





Leu Ser 

        





<210>  13

<211>  317

<212>  PRT

<213>  Human



<400>  13



Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 

1               5                   10                  15      





Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 

            20                  25                  30          





Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 

        35                  40                  45              





Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 

    50                  55                  60                  





Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 

65                  70                  75                  80  





Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 

                85                  90                  95      





Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 

            100                 105                 110         





Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 

        115                 120                 125             





Val Arg Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 

    130                 135                 140                 





Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 

145                 150                 155                 160 





Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 

                165                 170                 175     





Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 

            180                 185                 190         





Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 

        195                 200                 205             





Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 

    210                 215                 220                 





Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 

225                 230                 235                 240 





Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 

                245                 250                 255     





Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 

            260                 265                 270         





Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 

        275                 280                 285             





Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 

    290                 295                 300                 





Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 

305                 310                 315         





<210>  14

<211>  345

<212>  PRT

<213>  Human



<400>  14



Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 

1               5                   10                  15      





Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 

            20                  25                  30          





Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 

        35                  40                  45              





Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 

    50                  55                  60                  





Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 

65                  70                  75                  80  





Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 

                85                  90                  95      





Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 

            100                 105                 110         





Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 

        115                 120                 125             





Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 

    130                 135                 140                 





Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 

145                 150                 155                 160 





Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 

                165                 170                 175     





Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 

            180                 185                 190         





Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 

        195                 200                 205             





Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 

    210                 215                 220                 





Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 

225                 230                 235                 240 





Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 

                245                 250                 255     





Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 

            260                 265                 270         





Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 

        275                 280                 285             





Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 

    290                 295                 300                 





Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 

305                 310                 315                 320 





Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 

                325                 330                 335     





Thr Asp Ala Ser Asp Val Lys Pro Cys 

            340                 345 





<210>  15

<211>  4548

<212>  PRT

<213>  Human



<400>  15



Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 

1               5                   10                  15      





Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp 

            20                  25                  30          





Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 

        35                  40                  45              





Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr 

    50                  55                  60                  





Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 

65                  70                  75                  80  





Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg 

                85                  90                  95      





Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala 

            100                 105                 110         





Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser 

        115                 120                 125             





Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His 

    130                 135                 140                 





Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly 

145                 150                 155                 160 





Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg 

                165                 170                 175     





Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg 

            180                 185                 190         





Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly 

        195                 200                 205             





Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly 

    210                 215                 220                 





Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala 

225                 230                 235                 240 





Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys 

                245                 250                 255     





Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val 

            260                 265                 270         





Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His 

        275                 280                 285             





Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr 

    290                 295                 300                 





Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp 

305                 310                 315                 320 





Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala 

                325                 330                 335     





Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu 

            340                 345                 350         





Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln 

        355                 360                 365             





Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr 

    370                 375                 380                 





Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His 

385                 390                 395                 400 





Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met 

                405                 410                 415     





Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr 

            420                 425                 430         





Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser 

        435                 440                 445             





Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro 

    450                 455                 460                 





Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly 

465                 470                 475                 480 





Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr 

                485                 490                 495     





Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr 

            500                 505                 510         





Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu 

        515                 520                 525             





Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys 

    530                 535                 540                 





Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln 

545                 550                 555                 560 





Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro 

                565                 570                 575     





Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg 

            580                 585                 590         





Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly 

        595                 600                 605             





Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser 

    610                 615                 620                 





Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 

625                 630                 635                 640 





Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro 

                645                 650                 655     





Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu 

            660                 665                 670         





Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val 

        675                 680                 685             





Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu 

    690                 695                 700                 





Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr 

705                 710                 715                 720 





Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp 

                725                 730                 735     





Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro 

            740                 745                 750         





Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala 

        755                 760                 765             





Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys 

    770                 775                 780                 





Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro 

785                 790                 795                 800 





Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro 

                805                 810                 815     





Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln 

            820                 825                 830         





Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln 

        835                 840                 845             





Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr 

    850                 855                 860                 





Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala 

865                 870                 875                 880 





Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu 

                885                 890                 895     





Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala 

            900                 905                 910         





Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln 

        915                 920                 925             





Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn 

    930                 935                 940                 





Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 

945                 950                 955                 960 





Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro 

                965                 970                 975     





Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 

            980                 985                 990         





Asp Ala Val Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 

        995                 1000                 1005             





Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 

    1010                 1015                 1020             





Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 

    1025                 1030                 1035             





Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 

    1040                 1045                 1050             





Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 

    1055                 1060                 1065             





Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 

    1070                 1075                 1080             





His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 

    1085                 1090                 1095             





Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 

    1100                 1105                 1110             





Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 

    1115                 1120                 1125             





Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 

    1130                 1135                 1140             





Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 

    1145                 1150                 1155             





Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 

    1160                 1165                 1170             





Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 

    1175                 1180                 1185             





Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 

    1190                 1195                 1200             





Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 

    1205                 1210                 1215             





Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 

    1220                 1225                 1230             





Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 

    1235                 1240                 1245             





Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 

    1250                 1255                 1260             





Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 

    1265                 1270                 1275             





Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 

    1280                 1285                 1290             





Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 

    1295                 1300                 1305             





Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 

    1310                 1315                 1320             





Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 

    1325                 1330                 1335             





Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 

    1340                 1345                 1350             





Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 

    1355                 1360                 1365             





Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 

    1370                 1375                 1380             





Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 

    1385                 1390                 1395             





Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 

    1400                 1405                 1410             





Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 

    1415                 1420                 1425             





Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 

    1430                 1435                 1440             





Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 

    1445                 1450                 1455             





Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 

    1460                 1465                 1470             





Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 

    1475                 1480                 1485             





Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 

    1490                 1495                 1500             





Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 

    1505                 1510                 1515             





Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 

    1520                 1525                 1530             





Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 

    1535                 1540                 1545             





Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 

    1550                 1555                 1560             





Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 

    1565                 1570                 1575             





Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 

    1580                 1585                 1590             





Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 

    1595                 1600                 1605             





Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 

    1610                 1615                 1620             





Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 

    1625                 1630                 1635             





Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 

    1640                 1645                 1650             





His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 

    1655                 1660                 1665             





Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 

    1670                 1675                 1680             





Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 

    1685                 1690                 1695             





Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 

    1700                 1705                 1710             





Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 

    1715                 1720                 1725             





Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 

    1730                 1735                 1740             





Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 

    1745                 1750                 1755             





Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 

    1760                 1765                 1770             





Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 

    1775                 1780                 1785             





Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 

    1790                 1795                 1800             





Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 

    1805                 1810                 1815             





Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 

    1820                 1825                 1830             





Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 

    1835                 1840                 1845             





Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 

    1850                 1855                 1860             





Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 

    1865                 1870                 1875             





Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 

    1880                 1885                 1890             





Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 

    1895                 1900                 1905             





Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 

    1910                 1915                 1920             





Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 

    1925                 1930                 1935             





Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 

    1940                 1945                 1950             





Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 

    1955                 1960                 1965             





Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 

    1970                 1975                 1980             





Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 

    1985                 1990                 1995             





Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 

    2000                 2005                 2010             





Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 

    2015                 2020                 2025             





Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 

    2030                 2035                 2040             





Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 

    2045                 2050                 2055             





Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 

    2060                 2065                 2070             





Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 

    2075                 2080                 2085             





Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 

    2090                 2095                 2100             





Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 

    2105                 2110                 2115             





Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 

    2120                 2125                 2130             





Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 

    2135                 2140                 2145             





Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 

    2150                 2155                 2160             





Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 

    2165                 2170                 2175             





Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 

    2180                 2185                 2190             





Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 

    2195                 2200                 2205             





Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 

    2210                 2215                 2220             





His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 

    2225                 2230                 2235             





Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 

    2240                 2245                 2250             





Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 

    2255                 2260                 2265             





Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 

    2270                 2275                 2280             





Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 

    2285                 2290                 2295             





Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 

    2300                 2305                 2310             





Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 

    2315                 2320                 2325             





Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 

    2330                 2335                 2340             





Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 

    2345                 2350                 2355             





Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 

    2360                 2365                 2370             





Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 

    2375                 2380                 2385             





Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 

    2390                 2395                 2400             





Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 

    2405                 2410                 2415             





Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 

    2420                 2425                 2430             





Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 

    2435                 2440                 2445             





Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 

    2450                 2455                 2460             





Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 

    2465                 2470                 2475             





Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 

    2480                 2485                 2490             





Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 

    2495                 2500                 2505             





Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 

    2510                 2515                 2520             





Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 

    2525                 2530                 2535             





Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 

    2540                 2545                 2550             





Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 

    2555                 2560                 2565             





Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 

    2570                 2575                 2580             





Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 

    2585                 2590                 2595             





Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 

    2600                 2605                 2610             





Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 

    2615                 2620                 2625             





Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 

    2630                 2635                 2640             





Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 

    2645                 2650                 2655             





Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 

    2660                 2665                 2670             





Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 

    2675                 2680                 2685             





Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 

    2690                 2695                 2700             





Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 

    2705                 2710                 2715             





Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 

    2720                 2725                 2730             





Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 

    2735                 2740                 2745             





Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 

    2750                 2755                 2760             





Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 

    2765                 2770                 2775             





Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 

    2780                 2785                 2790             





His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 

    2795                 2800                 2805             





Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 

    2810                 2815                 2820             





Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 

    2825                 2830                 2835             





Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 

    2840                 2845                 2850             





Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 

    2855                 2860                 2865             





Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 

    2870                 2875                 2880             





Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 

    2885                 2890                 2895             





Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 

    2900                 2905                 2910             





Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 

    2915                 2920                 2925             





Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 

    2930                 2935                 2940             





Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 

    2945                 2950                 2955             





Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 

    2960                 2965                 2970             





Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 

    2975                 2980                 2985             





Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 

    2990                 2995                 3000             





Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 

    3005                 3010                 3015             





Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 

    3020                 3025                 3030             





Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 

    3035                 3040                 3045             





Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 

    3050                 3055                 3060             





Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 

    3065                 3070                 3075             





Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 

    3080                 3085                 3090             





Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 

    3095                 3100                 3105             





Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 

    3110                 3115                 3120             





Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 

    3125                 3130                 3135             





Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 

    3140                 3145                 3150             





Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 

    3155                 3160                 3165             





Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 

    3170                 3175                 3180             





Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 

    3185                 3190                 3195             





Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 

    3200                 3205                 3210             





Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 

    3215                 3220                 3225             





Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 

    3230                 3235                 3240             





Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 

    3245                 3250                 3255             





Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 

    3260                 3265                 3270             





Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 

    3275                 3280                 3285             





Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 

    3290                 3295                 3300             





Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 

    3305                 3310                 3315             





Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 

    3320                 3325                 3330             





Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 

    3335                 3340                 3345             





Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 

    3350                 3355                 3360             





His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 

    3365                 3370                 3375             





Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Pro Val Ala  Ala Pro Tyr 

    3380                 3385                 3390             





Cys Tyr  Thr Arg Asp Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu 

    3395                 3400                 3405             





Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 

    3410                 3415                 3420             





Ile Thr  Pro Ile Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 

    3425                 3430                 3435             





Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 

    3440                 3445                 3450             





Gln Ser  Tyr Gln Gly Thr Tyr  Phe Ile Thr Val Thr  Gly Arg Thr 

    3455                 3460                 3465             





Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 

    3470                 3475                 3480             





Pro Ala  Tyr Tyr Pro Asn Ala  Gly Leu Ile Lys Asn  Tyr Cys Arg 

    3485                 3490                 3495             





Asn Pro  Asp Pro Val Ala Ala  Pro Trp Cys Tyr Thr  Thr Asp Pro 

    3500                 3505                 3510             





Ser Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Arg Cys  Ser Asp Ala 

    3515                 3520                 3525             





Glu Trp  Thr Ala Phe Val Pro  Pro Asn Val Ile Leu  Ala Pro Ser 

    3530                 3535                 3540             





Leu Glu  Ala Phe Phe Glu Gln  Ala Leu Thr Glu Glu  Thr Pro Gly 

    3545                 3550                 3555             





Val Gln  Asp Cys Tyr Tyr His  Tyr Gly Gln Ser Tyr  Arg Gly Thr 

    3560                 3565                 3570             





Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 

    3575                 3580                 3585             





Met Thr  Pro His Gln His Ser  Arg Thr Pro Glu Asn  Tyr Pro Asn 

    3590                 3595                 3600             





Ala Gly  Leu Thr Arg Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile 

    3605                 3610                 3615             





Arg Pro  Trp Cys Tyr Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr 

    3620                 3625                 3630             





Cys Asn  Leu Thr Gln Cys Leu  Val Thr Glu Ser Ser  Val Leu Ala 

    3635                 3640                 3645             





Thr Leu  Thr Val Val Pro Asp  Pro Ser Thr Glu Ala  Ser Ser Glu 

    3650                 3655                 3660             





Glu Ala  Pro Thr Glu Gln Ser  Pro Gly Val Gln Asp  Cys Tyr His 

    3665                 3670                 3675             





Gly Asp  Gly Gln Ser Tyr Arg  Gly Ser Phe Ser Thr  Thr Val Thr 

    3680                 3685                 3690             





Gly Arg  Thr Cys Gln Ser Trp  Ser Ser Met Thr Pro  His Trp His 

    3695                 3700                 3705             





Gln Arg  Thr Thr Glu Tyr Tyr  Pro Asn Gly Gly Leu  Thr Arg Asn 

    3710                 3715                 3720             





Tyr Cys  Arg Asn Pro Asp Ala  Glu Ile Ser Pro Trp  Cys Tyr Thr 

    3725                 3730                 3735             





Met Asp  Pro Asn Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 

    3740                 3745                 3750             





Pro Val  Thr Glu Ser Ser Val  Leu Ala Thr Ser Thr  Ala Val Ser 

    3755                 3760                 3765             





Glu Gln  Ala Pro Thr Glu Gln  Ser Pro Thr Val Gln  Asp Cys Tyr 

    3770                 3775                 3780             





His Gly  Asp Gly Gln Ser Tyr  Arg Gly Ser Phe Ser  Thr Thr Val 

    3785                 3790                 3795             





Thr Gly  Arg Thr Cys Gln Ser  Trp Ser Ser Met Thr  Pro His Trp 

    3800                 3805                 3810             





His Gln  Arg Thr Thr Glu Tyr  Tyr Pro Asn Gly Gly  Leu Thr Arg 

    3815                 3820                 3825             





Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile Arg Pro  Trp Cys Tyr 

    3830                 3835                 3840             





Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr Cys Asn  Leu Thr Gln 

    3845                 3850                 3855             





Cys Pro  Val Met Glu Ser Thr  Leu Leu Thr Thr Pro  Thr Val Val 

    3860                 3865                 3870             





Pro Val  Pro Ser Thr Glu Leu  Pro Ser Glu Glu Ala  Pro Thr Glu 

    3875                 3880                 3885             





Asn Ser  Thr Gly Val Gln Asp  Cys Tyr Arg Gly Asp  Gly Gln Ser 

    3890                 3895                 3900             





Tyr Arg  Gly Thr Leu Ser Thr  Thr Ile Thr Gly Arg  Thr Cys Gln 

    3905                 3910                 3915             





Ser Trp  Ser Ser Met Thr Pro  His Trp His Arg Arg  Ile Pro Leu 

    3920                 3925                 3930             





Tyr Tyr  Pro Asn Ala Gly Leu  Thr Arg Asn Tyr Cys  Arg Asn Pro 

    3935                 3940                 3945             





Asp Ala  Glu Ile Arg Pro Trp  Cys Tyr Thr Met Asp  Pro Ser Val 

    3950                 3955                 3960             





Arg Trp  Glu Tyr Cys Asn Leu  Thr Arg Cys Pro Val  Thr Glu Ser 

    3965                 3970                 3975             





Ser Val  Leu Thr Thr Pro Thr  Val Ala Pro Val Pro  Ser Thr Glu 

    3980                 3985                 3990             





Ala Pro  Ser Glu Gln Ala Pro  Pro Glu Lys Ser Pro  Val Val Gln 

    3995                 4000                 4005             





Asp Cys  Tyr His Gly Asp Gly  Arg Ser Tyr Arg Gly  Ile Ser Ser 

    4010                 4015                 4020             





Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ser Trp Ser  Ser Met Ile 

    4025                 4030                 4035             





Pro His  Trp His Gln Arg Thr  Pro Glu Asn Tyr Pro  Asn Ala Gly 

    4040                 4045                 4050             





Leu Thr  Glu Asn Tyr Cys Arg  Asn Pro Asp Ser Gly  Lys Gln Pro 

    4055                 4060                 4065             





Trp Cys  Tyr Thr Thr Asp Pro  Cys Val Arg Trp Glu  Tyr Cys Asn 

    4070                 4075                 4080             





Leu Thr  Gln Cys Ser Glu Thr  Glu Ser Gly Val Leu  Glu Thr Pro 

    4085                 4090                 4095             





Thr Val  Val Pro Val Pro Ser  Met Glu Ala His Ser  Glu Ala Ala 

    4100                 4105                 4110             





Pro Thr  Glu Gln Thr Pro Val  Val Arg Gln Cys Tyr  His Gly Asn 

    4115                 4120                 4125             





Gly Gln  Ser Tyr Arg Gly Thr  Phe Ser Thr Thr Val  Thr Gly Arg 

    4130                 4135                 4140             





Thr Cys  Gln Ser Trp Ser Ser  Met Thr Pro His Arg  His Gln Arg 

    4145                 4150                 4155             





Thr Pro  Glu Asn Tyr Pro Asn  Asp Gly Leu Thr Met  Asn Tyr Cys 

    4160                 4165                 4170             





Arg Asn  Pro Asp Ala Asp Thr  Gly Pro Trp Cys Phe  Thr Met Asp 

    4175                 4180                 4185             





Pro Ser  Ile Arg Trp Glu Tyr  Cys Asn Leu Thr Arg  Cys Ser Asp 

    4190                 4195                 4200             





Thr Glu  Gly Thr Val Val Ala  Pro Pro Thr Val Ile  Gln Val Pro 

    4205                 4210                 4215             





Ser Leu  Gly Pro Pro Ser Glu  Gln Asp Cys Met Phe  Gly Asn Gly 

    4220                 4225                 4230             





Lys Gly  Tyr Arg Gly Lys Lys  Ala Thr Thr Val Thr  Gly Thr Pro 

    4235                 4240                 4245             





Cys Gln  Glu Trp Ala Ala Gln  Glu Pro His Arg His  Ser Thr Phe 

    4250                 4255                 4260             





Ile Pro  Gly Thr Asn Lys Trp  Ala Gly Leu Glu Lys  Asn Tyr Cys 

    4265                 4270                 4275             





Arg Asn  Pro Asp Gly Asp Ile  Asn Gly Pro Trp Cys  Tyr Thr Met 

    4280                 4285                 4290             





Asn Pro  Arg Lys Leu Phe Asp  Tyr Cys Asp Ile Pro  Leu Cys Ala 

    4295                 4300                 4305             





Ser Ser  Ser Phe Asp Cys Gly  Lys Pro Gln Val Glu  Pro Lys Lys 

    4310                 4315                 4320             





Cys Pro  Gly Ser Ile Val Gly  Gly Cys Val Ala His  Pro His Ser 

    4325                 4330                 4335             





Trp Pro  Trp Gln Val Ser Leu  Arg Thr Arg Phe Gly  Lys His Phe 

    4340                 4345                 4350             





Cys Gly  Gly Thr Leu Ile Ser  Pro Glu Trp Val Leu  Thr Ala Ala 

    4355                 4360                 4365             





His Cys  Leu Lys Lys Ser Ser  Arg Pro Ser Ser Tyr  Lys Val Ile 

    4370                 4375                 4380             





Leu Gly  Ala His Gln Glu Val  Asn Leu Glu Ser His  Val Gln Glu 

    4385                 4390                 4395             





Ile Glu  Val Ser Arg Leu Phe  Leu Glu Pro Thr Gln  Ala Asp Ile 

    4400                 4405                 4410             





Ala Leu  Leu Lys Leu Ser Arg  Pro Ala Val Ile Thr  Asp Lys Val 

    4415                 4420                 4425             





Met Pro  Ala Cys Leu Pro Ser  Pro Asp Tyr Met Val  Thr Ala Arg 

    4430                 4435                 4440             





Thr Glu  Cys Tyr Ile Thr Gly  Trp Gly Glu Thr Gln  Gly Thr Phe 

    4445                 4450                 4455             





Gly Thr  Gly Leu Leu Lys Glu  Ala Gln Leu Leu Val  Ile Glu Asn 

    4460                 4465                 4470             





Glu Val  Cys Asn His Tyr Lys  Tyr Ile Cys Ala Glu  His Leu Ala 

    4475                 4480                 4485             





Arg Gly  Thr Asp Ser Cys Gln  Gly Asp Ser Gly Gly  Pro Leu Val 

    4490                 4495                 4500             





Cys Phe  Glu Lys Asp Lys Tyr  Ile Leu Gln Gly Val  Thr Ser Trp 

    4505                 4510                 4515             





Gly Leu  Gly Cys Ala Arg Pro  Asn Lys Pro Gly Val  Tyr Ala Arg 

    4520                 4525                 4530             





Val Ser  Arg Phe Val Thr Trp  Ile Glu Gly Met Met  Arg Asn Asn 

    4535                 4540                 4545             





<210>  16

<211>  3305

<212>  PRT

<213>  Insect



<400>  16



Met Gly Lys Ser Asn Arg Leu Leu Ser Val Leu Phe Val Ile Ser Val 

1               5                   10                  15      





Leu Trp Lys Ala Ala Tyr Gly Asn Gly Lys Cys Gln Ile Ala Cys Lys 

            20                  25                  30          





Gly Ser Ser Ser Pro Ser Phe Ala Ala Gly Gln Lys Tyr Asn Tyr Gly 

        35                  40                  45              





Val Glu Gly Thr Val Ser Val Tyr Leu Thr Gly Ala Asp Asn Gln Glu 

    50                  55                  60                  





Thr Ser Leu Lys Met Leu Gly Gln Ala Ser Val Ser Ala Ile Ser Asn 

65                  70                  75                  80  





Cys Glu Leu Glu Leu Ser Val His Asn Met Val Leu Ser Gly Pro Asp 

                85                  90                  95      





Gly Lys Lys Tyr Pro Cys Pro Gln Gly Ile Glu Lys Pro Val Arg Phe 

            100                 105                 110         





Ser Tyr Gln Asp Gly Arg Val Gly Pro Glu Ile Cys Ala Ala Glu Asp 

        115                 120                 125             





Asp Ser Arg Arg Ser Leu Asn Ile Lys Arg Ala Ile Ile Ser Leu Leu 

    130                 135                 140                 





Gln Ala Glu Gln Lys Pro Ser Val Gln Val Asp Val Phe Gly Val Cys 

145                 150                 155                 160 





Pro Thr Glu Val Ser Ser Ser Gln Glu Gly Gly Ala Val Leu Leu His 

                165                 170                 175     





Arg Ser Arg Asp Leu Ser Arg Cys Ala His Arg Glu Gln Gly Arg Asn 

            180                 185                 190         





Asp Phe Val Asn Ser Ile Ala Asn Pro Asp Ala Gly Ile Lys Asp Leu 

        195                 200                 205             





Gln Val Leu Gln Ser Met Leu Asn Val Glu Ser Lys Val Asn Asn Gly 

    210                 215                 220                 





Val Pro Glu Lys Val Ser Ala Ile Glu Glu Tyr Leu Tyr Lys Pro Phe 

225                 230                 235                 240 





Ser Val Gly Glu Asn Gly Ala Arg Ala Lys Val His Thr Lys Leu Thr 

                245                 250                 255     





Leu Ser Gly Lys Gly Gly Ala Gly Gly Gly Asn Ala His Cys Thr Glu 

            260                 265                 270         





Ser Arg Ser Ile Ile Phe Asp Val Pro His Gly Thr Ser Ser Ala Ser 

        275                 280                 285             





Gly Asn Leu Asn Ser Val Ile Ser Ala Val Lys Glu Thr Ala Arg Thr 

    290                 295                 300                 





Val Ala Asn Asp Ala Ser Ser Lys Ser Ala Gly Gln Phe Ala Gln Leu 

305                 310                 315                 320 





Val Arg Ile Met Arg Thr Ser Ser Lys Asp Asp Leu Met Arg Ile Tyr 

                325                 330                 335     





Ser Gln Val Lys Ala His Gln Leu Glu Lys Arg Val Tyr Leu Asp Ala 

            340                 345                 350         





Leu Leu Arg Ala Gly Thr Gly Glu Ser Ile Glu Ala Ser Ile Gln Ile 

        355                 360                 365             





Leu Lys Ser Lys Asp Leu Ser Gln Leu Glu Gln His Leu Val Phe Leu 

    370                 375                 380                 





Ser Leu Gly Asn Ala Arg His Val Asn Asn Pro Ala Leu Lys Ala Ala 

385                 390                 395                 400 





Ala Gly Leu Leu Asp Met Pro Asn Leu Pro Lys Glu Val Tyr Leu Gly 

                405                 410                 415     





Ala Gly Ala Leu Gly Gly Ala Tyr Cys Arg Glu His Asp Cys His Asn 

            420                 425                 430         





Val Lys Pro Glu Gly Ile Val Ala Leu Ser Asn Lys Leu Gly Ser Lys 

        435                 440                 445             





Leu Gln Asn Cys Arg Pro Lys Asn Lys Pro Asp Glu Asp Val Val Val 

    450                 455                 460                 





Ala Ile Leu Lys Gly Ile Arg Asn Ile Arg His Leu Glu Asp Ser Leu 

465                 470                 475                 480 





Ile Asp Lys Leu Val His Cys Ala Val Asp Asn Asn Val Lys Ala Arg 

                485                 490                 495     





Val Arg Ala Val Ala Leu Glu Ala Phe His Ala Asp Pro Cys Ser Ala 

            500                 505                 510         





Lys Ile His Lys Thr Ala Met Asp Ile Met Lys Asn Arg Gln Leu Asp 

        515                 520                 525             





Ser Glu Ile Arg Ile Lys Ala Tyr Leu Ala Val Ile Glu Cys Pro Cys 

    530                 535                 540                 





Ser His Ser Ala Ser Glu Ile Lys Asn Leu Leu Asp Ser Glu Pro Val 

545                 550                 555                 560 





His Gln Val Gly Asn Phe Ile Thr Ser Ser Leu Arg His Ile Arg Ser 

                565                 570                 575     





Ser Ser Asn Pro Asp Lys Gln Leu Ala Lys Lys His Tyr Gly Gln Ile 

            580                 585                 590         





Arg Thr Pro Asn Lys Phe Lys Val Asp Glu Arg Lys Tyr Ser Phe Tyr 

        595                 600                 605             





Arg Glu Met Ser Tyr Lys Leu Asp Ala Leu Gly Ala Gly Gly Ser Val 

    610                 615                 620                 





Asp Gln Thr Val Ile Tyr Ser Gln Thr Ser Phe Leu Pro Arg Ser Val 

625                 630                 635                 640 





Asn Phe Asn Leu Thr Val Asp Leu Phe Gly Gln Ser Tyr Asn Val Met 

                645                 650                 655     





Glu Leu Gly Gly Arg Gln Gly Asn Leu Asp Arg Val Val Glu His Phe 

            660                 665                 670         





Leu Gly Pro Lys Ser Phe Leu Arg Thr Glu Asp Pro Gln Ala Leu Tyr 

        675                 680                 685             





Asp Asn Leu Val Lys Arg Phe Gln Glu Ser Lys Lys Lys Val Glu Asp 

    690                 695                 700                 





Ser Leu Ser Arg Gly Arg Arg Ser Ile Lys Ser Glu Ile Asp Val Phe 

705                 710                 715                 720 





Asp Lys Asn Leu Lys Ala Glu Ser Ala Pro Tyr Asn Asn Glu Leu Asp 

                725                 730                 735     





Leu Asp Ile Tyr Val Lys Leu Phe Gly Thr Asp Ala Val Phe Leu Ser 

            740                 745                 750         





Phe Gly Asp Asp Lys Gly Phe Asp Phe Asn Lys Met Leu Asp Gln Ile 

        755                 760                 765             





Leu Gly Gly Cys Asn Ser Gly Ile Asn Lys Ala Lys His Phe Gln Gln 

    770                 775                 780                 





Glu Ile Arg Ser His Leu Leu Phe Met Asp Ala Glu Leu Ala Tyr Pro 

785                 790                 795                 800 





Thr Ser Val Gly Leu Pro Leu Arg Leu Asn Leu Ile Gly Ala Ala Thr 

                805                 810                 815     





Ala Arg Leu Asp Val Ala Thr Asn Ile Asp Ile Arg Gln Ile Phe Gln 

            820                 825                 830         





Ser Pro Gln Asn Ala Lys Ala Asp Ile Lys Phe Val Pro Ser Thr Asp 

        835                 840                 845             





Phe Glu Ile Ser Gly Ala Phe Ile Ile Asp Ala Asp Ala Phe Ser Thr 

    850                 855                 860                 





Gly Ile Lys Val Ile Thr Asn Leu His Ser Ser Thr Gly Val His Val 

865                 870                 875                 880 





Asn Ala Lys Val Leu Glu Asn Gly Arg Gly Ile Asp Leu Gln Ile Gly 

                885                 890                 895     





Leu Pro Val Asp Lys Gln Glu Leu Ile Ala Ala Ser Ser Asp Leu Val 

            900                 905                 910         





Phe Val Thr Ala Glu Lys Gly Gln Lys Glu Lys Gln Lys Val Ile Lys 

        915                 920                 925             





Met Glu Lys Gly Glu Asn Glu Tyr Ser Ala Cys Phe Asp Gln Leu Ser 

    930                 935                 940                 





Gly Pro Leu Gly Leu Thr Met Cys Tyr Asp Met Val Leu Pro Phe Pro 

945                 950                 955                 960 





Ile Val Asn Arg Asn Asp Lys Leu Asp Ser Ile Ala Lys Ala Met Gly 

                965                 970                 975     





Lys Trp Pro Leu Ser Gly Ser Ala Lys Phe Lys Leu Phe Leu Glu Lys 

            980                 985                 990         





Asn Asp Leu Arg Gly Tyr His Ile  Lys Ala Val Val Lys  Glu Asp Lys 

        995                 1000                 1005             





Asp Ala  Gly Arg Arg Ser Phe  Glu Leu Leu Leu Asp  Thr Glu Gly 

    1010                 1015                 1020             





Ala Lys  Thr Arg Arg Ser Gln  Leu Thr Gly Glu Ala  Val Tyr Asn 

    1025                 1030                 1035             





Glu Asn  Glu Val Gly Val Lys  Leu Gly Leu Glu Ala  Val Gly Lys 

    1040                 1045                 1050             





Val Ile  Tyr Gly His Ile Trp  Ala His Lys Lys Pro  Asn Glu Leu 

    1055                 1060                 1065             





Val Ala  Ser Val Lys Gly Lys  Leu Asp Asp Ile Glu  Tyr Ser Gly 

    1070                 1075                 1080             





Lys Leu  Gly Phe Ser Val Gln  Gly Asn Glu His Arg  Ala Val Tyr 

    1085                 1090                 1095             





Lys Pro  Ile Phe Glu Tyr Ser  Leu Pro Asp Gly Ser  Ser Pro Gly 

    1100                 1105                 1110             





Ser Lys  Lys Tyr Glu Val Lys  Ile Asp Gly Gln Val  Ile Arg Glu 

    1115                 1120                 1125             





Cys Asp  Gly Arg Val Thr Lys  Tyr Thr Phe Asp Gly  Val His Val 

    1130                 1135                 1140             





Asn Leu  Gln Asn Ala Glu Lys  Pro Leu Glu Ile Cys  Gly Ser Val 

    1145                 1150                 1155             





Ser Thr  Val Ala Gln Pro Arg  Glu Val Glu Phe Asp  Val Glu Val 

    1160                 1165                 1170             





Lys His  Tyr Ala Ser Leu Lys  Gly Ser Trp Lys Gly  Ser Asp Val 

    1175                 1180                 1185             





Val Leu  Ala Phe Asn Asn Gln  Leu Asn Pro Lys Ile  Asn Phe Asp 

    1190                 1195                 1200             





Leu Lys  Gly Lys Phe Glu Asn  Thr Asp Ser Met His  Asn Glu Leu 

    1205                 1210                 1215             





Asp Ile  His Tyr Gly Pro Asn  Arg Gly Asp Asn Asn  Ala Arg Ile 

    1220                 1225                 1230             





Thr Phe  Ser Gln Ile Leu Lys  Tyr His Val Glu Asn  Ser Lys Asn 

    1235                 1240                 1245             





Phe Asn  Val Ile Thr Lys Asn  Asn Leu Glu Ile Arg  Ala Val Pro 

    1250                 1255                 1260             





Phe Lys  Leu Val Ala Asn Ala  Asp Val Asp Pro Lys  Lys Ile Asp 

    1265                 1270                 1275             





Ile Asp  Ile Glu Gly Gln Leu  Gln Asp Lys Ser Ala  Gly Phe Asn 

    1280                 1285                 1290             





Leu Asp  Ala Arg Thr His Ile  Lys Lys Glu Gly Asp  Tyr Ser Ile 

    1295                 1300                 1305             





Lys Val  Lys Ala Asn Leu Asn  Asn Ala Asn Leu Glu  Ala Phe Ser 

    1310                 1315                 1320             





Arg Arg  Asp Ile Val Asn Ala  Glu Lys Ser Asn Val  Glu Asn Tyr 

    1325                 1330                 1335             





Ile Asp  Met Lys Gly Val Gly  Arg Tyr Glu Leu Ser  Gly Phe Val 

    1340                 1345                 1350             





Leu His  Lys Thr Lys Pro Asn  Asp Val Asn Val Gly  Phe Ile Gly 

    1355                 1360                 1365             





His Leu  Lys Ile Asn Gly Gly  Gly Lys Asn Glu Asp  Phe Lys Ile 

    1370                 1375                 1380             





Asn Ile  Gly His Ile Glu Thr  Pro Ala Val Phe Ser  Ser His Ala 

    1385                 1390                 1395             





Thr Ile  Ser Gly Ser Arg Gly  Asp Ile Ile Asp Tyr  Leu Leu Lys 

    1400                 1405                 1410             





Ile Met  Arg Thr Ala Asn Pro  Asn Gly Asn Phe Lys  Leu Val Ile 

    1415                 1420                 1425             





Lys Asp  Ser Ile Ala Ala Asn  Gly Gln Tyr Lys Val  Thr Asp Ala 

    1430                 1435                 1440             





Asp Gly  Lys Gly Asn Gly Leu  Ile Ile Ile Asp Phe  Lys Lys Ile 

    1445                 1450                 1455             





Asn Arg  Lys Ile Lys Gly Asp  Val Arg Phe Thr Ala  Lys Glu Pro 

    1460                 1465                 1470             





Val Phe  Asn Ala Asp Ile Asp  Leu Phe Leu Asn Phe  Glu Lys Asp 

    1475                 1480                 1485             





Asn Ser  Asp Lys Val His Phe  Ser Thr Tyr Asn Lys  Lys Thr Asp 

    1490                 1495                 1500             





Lys Val  Met Asp Thr Lys Asn  Lys Leu Glu Tyr Ala  Gly Lys Arg 

    1505                 1510                 1515             





Thr Glu  Val Asn Ile His Gln  Asp Gly Ile Leu Ala  Val Thr Gly 

    1520                 1525                 1530             





Lys Ala  His Thr Val Ala Glu  Leu Val Leu Pro Thr  Glu Arg Cys 

    1535                 1540                 1545             





Leu Ser  Leu Lys Ile Asp His  Asp Gly Ala Phe Lys  Asp Gly Leu 

    1550                 1555                 1560             





Tyr Asn  Gly His Met Asp Met  Thr Ile Ser Asp Ala  Pro Lys Arg 

    1565                 1570                 1575             





Gly Ser  Gly Ala Ser Thr Ile  Ser Tyr Lys Gly Lys  Val Ser Asn 

    1580                 1585                 1590             





Ser Asn  Leu Asp Gln Glu Ile  Ile Asp Tyr Glu Gly  Gln Ile Asn 

    1595                 1600                 1605             





Phe Lys  Leu Lys Asp Gly Lys  Asn Leu Gln Ser Thr  Phe Ser Leu 

    1610                 1615                 1620             





Lys Asn  Asn Pro Asp Gly Asp  Lys Phe Lys Tyr Glu  Phe Lys Ser 

    1625                 1630                 1635             





Asp Val  Asn Gly Asn Leu Ile  Pro Lys Pro Ala Asn  Leu Val Ala 

    1640                 1645                 1650             





Thr Gly  Thr Tyr Ser Asn Ser  Glu Asn Glu Ile Asp  Glu Thr Tyr 

    1655                 1660                 1665             





Arg Leu  Lys Gly Ser Tyr Gly  Ser Asp Ile Gly Phe  Glu Leu Ala 

    1670                 1675                 1680             





Gly Val  Gly Thr Ile Lys Phe  Leu Asp Ala Gly Asp  Lys Lys Tyr 

    1685                 1690                 1695             





Leu Asp  Asp Tyr Thr Leu Thr  Val Arg Leu Pro Phe  Glu Lys Ala 

    1700                 1705                 1710             





His Asp  Ile Lys Trp Val Ser  Thr Val Leu Phe Leu  Gln Pro Gln 

    1715                 1720                 1725             





Gly Gln  Glu Met Thr Glu Tyr  Thr Leu Val Glu Ser  Val Gln Ile 

    1730                 1735                 1740             





Asn Ala  Asp Val Tyr Lys Ile  Asp Ala Asn Gly Lys  Val Gly Pro 

    1745                 1750                 1755             





Lys Asn  Gly Tyr Gly Ala Val  Lys Val Leu Val Pro  His Val Glu 

    1760                 1765                 1770             





Pro Phe  Val Leu Asp Tyr Asn  Tyr Lys Ser Ser His  Glu Gly Glu 

    1775                 1780                 1785             





Lys Asn  Asn Asn Tyr Val Glu  Leu Lys Thr Lys Tyr  Gly Lys Gly 

    1790                 1795                 1800             





Lys Ser  Ala Ser Met Val Val  Asp Ser Ser Tyr Ala  Pro His Tyr 

    1805                 1810                 1815             





Ser Thr  Leu Lys Val Lys Ala  Asn Thr Pro Asn Asn  Asp Lys Phe 

    1820                 1825                 1830             





Lys Lys  Leu Asp Val Thr Val  His Ser Lys Asn Pro  Ser Pro Asp 

    1835                 1840                 1845             





Ala Tyr  Ser Asn Ser Val Val  Val Asp Ala Asp Gly  Arg Val Tyr 

    1850                 1855                 1860             





Lys Ile  Asp Ser Ser Ile Val  Leu Ser Lys Ala His  Pro Val Leu 

    1865                 1870                 1875             





Asp Ile  Gln Tyr His Ser Pro  Ser Ser Asp Lys Ile  Arg Arg Leu 

    1880                 1885                 1890             





Tyr Leu  Gln Gly Ser Ser Leu  Ser Ser Thr Gln Gly  Lys Leu Glu 

    1895                 1900                 1905             





Val Lys  Val Asp Asn Ile Asn  Asp Ile Cys Leu Asp  Ala Val Ser 

    1910                 1915                 1920             





Glu Ala  Asn Val Gln Lys Asp  Asn Val Ala Phe Lys  Val Val Ala 

    1925                 1930                 1935             





Asn Ala  Lys Glu Leu Gly Trp  Lys Asn Tyr Gly Ile  Asp Ile Ser 

    1940                 1945                 1950             





Ser Lys  Asp Ser Gly Ser Gly  Lys Arg Leu Glu Phe  His Ala Thr 

    1955                 1960                 1965             





Asn Asp  Asn Lys Asn Val Leu  Ser Gly Ser Thr Ser  Phe Ile Ser 

    1970                 1975                 1980             





Lys Gln  Glu Gly Gln Lys Thr  Ile Ile Glu Gly Ser  Gly Ser Val 

    1985                 1990                 1995             





Lys Val  Lys Glu Glu Gln Lys  Ser Ala Asn Phe Lys  Tyr Ile Arg 

    2000                 2005                 2010             





Thr Val  Phe Thr Asp Ser Asn  Glu Lys Gly Val Glu  Thr Phe Phe 

    2015                 2020                 2025             





Asn Val  Ala Leu Gly Glu Arg  Ser Tyr Val Ala Glu  Ser Arg Val 

    2030                 2035                 2040             





Thr Asn  Tyr Glu Tyr Lys Asn  Ser Tyr Val Tyr Cys  Glu Glu Lys 

    2045                 2050                 2055             





Lys Gln  Cys Ala His Ala Glu  Ile Gln Ser Lys Ile  Asp Met Ser 

    2060                 2065                 2070             





Thr Pro  Gly Met Ile Val Asn  Val Ile Asn Ala Gly  Leu Asp Leu 

    2075                 2080                 2085             





Arg Lys  Leu Gly Val Ala Pro  Glu Leu Gly Leu Gln  Met Arg Asp 

    2090                 2095                 2100             





Glu Val  Ser Asp Arg Arg Pro  Pro Arg Phe Thr Leu  Asp Leu His 

    2105                 2110                 2115             





Ile Asn  Lys Glu Asp Arg Lys  Tyr His Leu His Ala  Tyr Asn Thr 

    2120                 2125                 2130             





Pro Glu  Asn Gly His Tyr Ala  Ser Gly Val Thr Val  Arg Leu Pro 

    2135                 2140                 2145             





Ser Arg  Val Met Ala Leu Glu  Tyr Thr Leu Thr His  Pro Thr Ser 

    2150                 2155                 2160             





Gln Asp  Leu Pro Phe Pro Ile  Lys Gly Glu Ala Cys  Leu Asp Leu 

    2165                 2170                 2175             





Asp Lys  Asn Arg Pro Gly His  Lys Thr Ser Ala Arg  Phe Leu Val 

    2180                 2185                 2190             





Asp Tyr  Ser Asn Ser Gly Ser  Glu Asp Lys Ala Val  Ala Glu Ile 

    2195                 2200                 2205             





Gly Phe  Phe His Pro Lys Ile  Glu Lys Glu Ala Val  Ile Arg Leu 

    2210                 2215                 2220             





Asn Ala  Phe Met Lys Arg Pro  Glu Asn Gly Cys Phe  Lys Ile Glu 

    2225                 2230                 2235             





Ser Ser  Ala Ser Leu Cys His  Ser Ala Leu Gly Thr  Asp Arg Val 

    2240                 2245                 2250             





Ala Lys  Val Met Phe Glu Thr  Thr Pro Asn Ser Val  Lys Phe Leu 

    2255                 2260                 2265             





Ala Asp  Thr Pro Phe Val Lys  Ala Ile Asp Val Glu  Gly Ser Phe 

    2270                 2275                 2280             





Asn Val  Asn Gln Gln Gln Arg  Thr Gln Gln Cys Leu  Phe Arg Ile 

    2285                 2290                 2295             





Cys Leu  Leu Glu Gly Lys Pro  Val Gln Met Ser Ala  Leu Val Lys 

    2300                 2305                 2310             





Asp Tyr  Gln Tyr Tyr Glu Phe  Thr Thr Glu Glu Ser  Asn Arg Lys 

    2315                 2320                 2325             





Leu Ser  Tyr Val Gly His Leu  Ile Pro Glu Lys Arg  Val Asp Ile 

    2330                 2335                 2340             





Ser Thr  Asp Ile Ile Leu Ser  Gly Asp Lys Lys Asn  Ile Ala His 

    2345                 2350                 2355             





Gly Ala  Leu Phe Leu Gln Asp  Asn Leu Val Lys Ser  Asp Tyr Gly 

    2360                 2365                 2370             





Leu Ser  Lys Glu Asn Phe Asn  Tyr Phe Leu Asn Ala  Leu Lys Lys 

    2375                 2380                 2385             





Asp Leu  Asp Thr Leu Glu Asp  Arg Ile Lys Asn Val  Gly Glu Lys 

    2390                 2395                 2400             





Ala Ser  Lys Asp Val Glu Ala  Val Thr Gln Arg Ala  Ala Pro Tyr 

    2405                 2410                 2415             





Phe Lys  Lys Val Glu Asp Asn  Phe Arg Ala Glu Trp  Asn Arg Phe 

    2420                 2425                 2430             





Tyr Gln  Glu Ile Ala Asp Asp  Lys Val Phe Lys Glu  Ile Ser His 

    2435                 2440                 2445             





Val Phe  Asn Glu Ile Val Gln  Tyr Ile Ala Lys Phe  Ile Asp Glu 

    2450                 2455                 2460             





Ile Leu  Gln Gly Thr Lys Arg  Ser Trp Thr Pro Ser  Cys Arg Pro 

    2465                 2470                 2475             





Thr Leu  Ser His Pro Arg Asn  Arg Glu Met Tyr Lys  Lys Gln Ile 

    2480                 2485                 2490             





Glu Pro  Gln Val Lys Gln Leu  Tyr Asp Thr Leu Gly  Ala Leu Met 

    2495                 2500                 2505             





Lys Glu  Tyr Leu Asp Gly Val  Ile Asp Val Val Ala  His Phe Ala 

    2510                 2515                 2520             





Ala Ile  Val Thr Asp Phe Phe  Glu Lys His Lys Ala  Glu Leu Gln 

    2525                 2530                 2535             





Glu Leu  Thr Asn Val Phe Thr  Glu Ile Phe Lys Asp  Leu Thr Arg 

    2540                 2545                 2550             





Leu Val  Val Ala Gln Leu Lys  Glu Leu Pro Pro Lys  Ile Ala Gln 

    2555                 2560                 2565             





Ile Tyr  Asn Asp Ile Val Ser  Gln Ile Thr Asn Met  Pro Phe Val 

    2570                 2575                 2580             





Val Val  Leu Gln Glu Lys Trp  Lys Glu Phe Asn Phe  Ala Glu Arg 

    2585                 2590                 2595             





Ala Val  Gln Leu Val Ser Gln  Ala Tyr Glu Ala Phe  Ser Lys Ile 

    2600                 2605                 2610             





Leu Pro  Thr Asp Glu Leu Lys  Glu Phe Ala Lys Ala  Leu Asn Ala 

    2615                 2620                 2625             





Tyr Leu  Leu Lys Lys Ile Lys  Glu Glu Lys Met Glu  Glu Ser Lys 

    2630                 2635                 2640             





Glu Leu  Pro Arg Ala Val Arg  Glu Ala Gly Gln Arg  Val Leu Leu 

    2645                 2650                 2655             





Ile Thr  Ser Ile Pro Ala Leu  Ala Val Arg Arg Pro  Arg Leu Arg 

    2660                 2665                 2670             





Arg Trp  Thr Trp His His Leu  Lys Leu Ala Val Gly  Ala Gly Ala 

    2675                 2680                 2685             





Ser Ala  Pro Ser Leu Gly Ala  Ala Ser Trp Ser Ala  Leu Arg Gln 

    2690                 2695                 2700             





Leu Ala  Ala Gly Asp Gly Pro  Pro Ala Leu Ala Pro  Arg Gly Leu 

    2705                 2710                 2715             





Pro Thr  Ala Gln Leu Asp Pro  Leu Asp Glu Val Pro  Asn Lys Leu 

    2720                 2725                 2730             





Arg Ala  Val Val Val Asn Gly  Gln His Ile Phe Thr  Phe Asp Gly 

    2735                 2740                 2745             





Arg His  Leu Thr Phe Pro Gly  Thr Cys Arg Tyr Val  Leu Ile His 

    2750                 2755                 2760             





Asp His  Val Asp Arg Asn Phe  Thr Val Leu Met Gln  Leu Ala Asn 

    2765                 2770                 2775             





Gly Gln  Pro Lys Ala Leu Val  Leu Glu Asp Lys Ser  Gly Thr Ile 

    2780                 2785                 2790             





Ile Glu  Leu Lys Asp Asn Gly  Gln Val Ile Leu Asn  Cys Gln Ser 

    2795                 2800                 2805             





His Gly  Phe Pro Val Val Glu  Gln Asp Val Phe Ala  Phe Arg Gln 

    2810                 2815                 2820             





Thr Ser  Gly Arg Ile Gly Leu  Cys Ser Lys Tyr Gly  Leu Met Ala 

    2825                 2830                 2835             





Phe Cys  Thr Ser Lys Phe Glu  Val Cys Tyr Phe Glu  Val Asn Gly 

    2840                 2845                 2850             





Phe Tyr  Leu Gly Lys Leu Pro  Gly Leu Leu Gly Asp  Gly Asn Asn 

    2855                 2860                 2865             





Glu Pro  Tyr Asp Asp Phe Arg  Met Pro Asn Gly Lys  Ile Cys Ser 

    2870                 2875                 2880             





Ser Glu  Ser Glu Phe Gly Asn  Ser Tyr Arg Leu Ser  Arg Ser Cys 

    2885                 2890                 2895             





Pro Ala  Ala Asn Ala Pro Ala  His Asp His His Gln  Met His Ala 

    2900                 2905                 2910             





Pro Leu  Pro Lys Pro Cys Glu  Arg Val Phe Ser Gly  Thr Ser Pro 

    2915                 2920                 2925             





Leu Arg  Pro Leu Ser Leu Met  Leu Asp Ile Ala Pro  Phe Arg Gln 

    2930                 2935                 2940             





Ala Cys  Ile His Ala Val Thr  Gly Ala Asp Ala Asp  Lys Asp Leu 

    2945                 2950                 2955             





Gln Gln  Ala Cys Asp Leu Ala  Arg Gly Tyr Arg Arg  Ser Arg Ser 

    2960                 2965                 2970             





Arg Gly  Cys Cys Pro Pro Arg  Cys Pro Thr Pro Ala  Cys Ala Ala 

    2975                 2980                 2985             





Arg Thr  Ala Thr Gly Pro Gly  Ser Trp Ala Thr Pro  Thr Ser Thr 

    2990                 2995                 3000             





Asn Cys  Pro Thr Asp Ser Leu  Ile Ser Ser Ser Pro  Leu Arg Pro 

    3005                 3010                 3015             





Leu Arg  Thr Thr Pro Ala His  Tyr Lys Asn Met Val  Val Pro Leu 

    3020                 3025                 3030             





Val Ser  Gln Leu Val Asp Met  Leu Lys Gly Lys His  Cys Thr Asp 

    3035                 3040                 3045             





Ile Lys  Val Phe Leu Val Gly  His Thr Ser Lys His  Pro Tyr Pro 

    3050                 3055                 3060             





Ile Leu  Tyr Asp Thr Asp Leu  Lys Leu Lys Asn Ala  Lys Val Ser 

    3065                 3070                 3075             





Phe Asp  Asp Lys Ser Arg Tyr  Asp Arg Ile Pro Phe  Val Lys Thr 

    3080                 3085                 3090             





Gly His  Glu Lys Phe Asp Ser  Tyr Ser Lys Thr Val  Val Asp Phe 

    3095                 3100                 3105             





Leu Asn  Tyr Ile Lys Ile Glu  Leu Gly Ile Thr Asn  Ile Glu Ala 

    3110                 3115                 3120             





Ser Gln  Gly Gln Ile Phe Asp  Leu Pro Leu Arg Pro  Gly Ala Val 

    3125                 3130                 3135             





Lys His  Val Ile Phe Val Thr  Gly Gly Pro Thr Ile  Ser Gln Phe 

    3140                 3145                 3150             





Phe Leu  Leu Glu Thr Val Arg  Ala Leu Arg Asn Lys  Val Ile Ile 

    3155                 3160                 3165             





Asp Glu  Met Ala Met Ser Ala  Ser Leu Val Thr Ser  Thr Pro Gly 

    3170                 3175                 3180             





Leu Lys  Ile Gly Gly Gly Lys  Asn Ala Ala Gln Ile  Val Gly Tyr 

    3185                 3190                 3195             





Glu Lys  His Gly Val Leu Leu  Leu Gly Glu Lys Lys  Gln Ser Lys 

    3200                 3205                 3210             





Asp Ser  Glu Ala Val Arg Ala  Thr Leu Glu Val Glu  Asp Asp Pro 

    3215                 3220                 3225             





Phe Ser  Asp Ala Val Glu Phe  Ala Asn Gly Val Val  Phe Ser Ala 

    3230                 3235                 3240             





Ser Asn  Tyr Ala Ala Leu Pro  Ala Gly Gln Gln Lys  Gln Phe Ile 

    3245                 3250                 3255             





Gln Thr  Ala Ala His Asn Ile  Ile Gln Arg Met Trp  Arg Glu Gln 

    3260                 3265                 3270             





Ile Val  Gln Gln Cys Thr Cys  Val Phe Val Asp Pro  Phe Arg Val 

    3275                 3280                 3285             





Arg Ser  Val Cys Phe Asn Lys  Ala Arg Thr Glu Val  Ala Arg Arg 

    3290                 3295                 3300             





Arg Lys  

    3305 





<210>  17

<211>  386

<212>  PRT

<213>  Insect



<400>  17



Gln Gln Thr Phe Lys Asn Gly Val Leu Glu Ser Val Lys Leu Gly Glu 

1               5                   10                  15      





Glu Tyr Lys Tyr Val Pro Phe Ala Lys Leu Asn Ser Gly Ala Gln Ala 

            20                  25                  30          





Lys Val Thr Thr Lys Leu Thr Tyr Thr Gly Thr Lys Ala Gly Ala Ala 

        35                  40                  45              





Pro Ala Leu Thr Ala Gly Ala Pro Arg Ser Val Ile Phe Glu Asn Pro 

    50                  55                  60                  





Gln Thr Asp Ser Gln Gly Asn Leu Glu Thr Ile Lys Gln Glu Leu Lys 

65                  70                  75                  80  





Thr Val Val Asp Ser Tyr Ser Gln Asn Asn Val Gly Lys Leu Thr Ala 

                85                  90                  95      





Ser His Phe Thr Glu Leu Val His Leu Met Arg Phe Ser Lys Lys Asp 

            100                 105                 110         





Asp Leu Leu Ser Leu Tyr Gln Gln Val Lys Ala Gly Asn Ala His Lys 

        115                 120                 125             





Asn Lys Leu Leu Ala Arg Lys Val Tyr Phe Asp Ala Leu Phe Arg Ala 

    130                 135                 140                 





Gly Thr Gly Ala Ser Val Glu Ala Leu Ala Asn Leu Tyr Lys Asn Lys 

145                 150                 155                 160 





Glu Val Ser Asp Ala Lys Glu Gln Lys Leu Leu Phe Val Ser Leu Asn 

                165                 170                 175     





Leu Val Thr Ser Met Thr Lys Pro Ala Leu Lys Ala Ala Lys Leu Leu 

            180                 185                 190         





Leu Asp Gly Asn Pro Ser Arg Glu Ala Tyr Leu Ser Val Gly Ser Leu 

        195                 200                 205             





Val Asn Lys Tyr Cys Gln Lys Phe Gly Cys Glu Ser Ala Asp Val Lys 

    210                 215                 220                 





Glu Ile Ser Asp Lys Phe Ser Ala Lys Leu Gly Lys Cys Gln Pro Thr 

225                 230                 235                 240 





Thr Arg Gln Glu Glu Asp Thr Ile Val Ala Val Leu Lys Gly Ile Lys 

                245                 250                 255     





Asn Ser Asn Thr Leu Val Ala Gln Leu Leu Asp Lys Val Val Gly Cys 

            260                 265                 270         





Ala Ser Asp Lys Ser Ser Ala Arg Val Arg Val Ala Ala Phe Gln Ala 

        275                 280                 285             





Tyr Pro Ala Ala Ser Cys Asn Lys Lys Ile Val Asn Ser Ala Leu Asn 

    290                 295                 300                 





Phe Leu Lys Asn Val Asn Glu Asp Ser Glu Ile Arg Ile Gln Ala Tyr 

305                 310                 315                 320 





Leu Ser Pro Val Glu Cys Pro Ser Ala Ala Val Ala Asn Glu Ile Lys 

                325                 330                 335     





Ala Leu Leu Asp Asn Glu Lys Val Tyr Gln Val Gly Ser Phe Leu Thr 

            340                 345                 350         





Thr His Leu Ala Ser Leu Arg Ala Ser Ala Asp Pro Thr Arg Asp Ala 

        355                 360                 365             





Ala Arg Gln His Phe Ala Asn Ile Arg Thr Thr Asn Gln Phe Pro Phe 

    370                 375                 380                 





Asp Phe 

385     





<210>  18

<211>  189

<212>  PRT

<213>  Insect



<400>  18



Met Ala Ala Lys Phe Val Val Val Leu Ala Ala Cys Val Ala Leu Ser 

1               5                   10                  15      





His Ser Ala Met Val Arg Arg Asp Ala Pro Ala Gly Gly Asn Ala Phe 

            20                  25                  30          





Glu Glu Met Glu Lys His Ala Lys Glu Phe Gln Lys Thr Phe Ser Glu 

        35                  40                  45              





Gln Phe Asn Ser Leu Val Asn Ser Lys Asn Thr Gln Asp Phe Asn Lys 

    50                  55                  60                  





Ala Leu Lys Asp Gly Ser Asp Ser Val Leu Gln Gln Leu Ser Ala Phe 

65                  70                  75                  80  





Ser Ser Ser Leu Gln Gly Ala Ile Ser Asp Ala Asn Gly Lys Ala Lys 

                85                  90                  95      





Glu Ala Leu Glu Gln Ala Arg Gln Asn Val Glu Lys Thr Ala Glu Glu 

            100                 105                 110         





Leu Arg Lys Ala His Pro Asp Val Glu Lys Glu Ala Asn Ala Phe Lys 

        115                 120                 125             





Asp Lys Leu Gln Ala Ala Val Gln Thr Thr Val Gln Glu Ser Gln Lys 

    130                 135                 140                 





Leu Ala Lys Glu Val Ala Ser Asn Met Glu Glu Thr Asn Lys Lys Leu 

145                 150                 155                 160 





Ala Pro Lys Ile Lys Gln Ala Tyr Asp Asp Phe Val Lys His Ala Glu 

                165                 170                 175     





Glu Val Gln Lys Lys Leu His Glu Ala Ala Thr Lys Gln 

            180                 185                 





<210>  19

<211>  212

<212>  PRT

<213>  Synthetic



<400>  19



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln 

    210         





<210>  20

<211>  201

<212>  PRT

<213>  Synthetic



<400>  20



Met Ala Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser 

1               5                   10                  15      





Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn 

            20                  25                  30          





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 

        35                  40                  45              





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    50                  55                  60                  





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu 

65                  70                  75                  80  





Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln 

                85                  90                  95      





Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala 

            100                 105                 110         





His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu 

        115                 120                 125             





Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly 

    130                 135                 140                 





Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr 

145                 150                 155                 160 





Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu 

                165                 170                 175     





Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu 

            180                 185                 190         





Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

        195                 200     





<210>  21

<211>  414

<212>  PRT

<213>  Synthetic



<400>  21



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr Leu Lys Leu Leu Asp Asn Trp Asp Ser Val 

    210                 215                 220                 





Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln 

225                 230                 235                 240 





Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu 

                245                 250                 255     





Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu 

            260                 265                 270         





Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln 

        275                 280                 285             





Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys 

    290                 295                 300                 





Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg 

305                 310                 315                 320 





Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro 

                325                 330                 335     





Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu 

            340                 345                 350         





Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr 

        355                 360                 365             





Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp 

    370                 375                 380                 





Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe 

385                 390                 395                 400 





Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

                405                 410                 





<210>  22

<211>  422

<212>  PRT

<213>  Synthetic



<400>  22



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr Gly Gly Gly Ser Gly Gly Gly Thr Leu Lys 

    210                 215                 220                 





Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg 

225                 230                 235                 240 





Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys 

                245                 250                 255     





Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val 

            260                 265                 270         





Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln 

        275                 280                 285             





Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu 

    290                 295                 300                 





Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu 

305                 310                 315                 320 





Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp 

                325                 330                 335     





Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg 

            340                 345                 350         





Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu 

        355                 360                 365             





Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu 

    370                 375                 380                 





Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val 

385                 390                 395                 400 





Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr 

                405                 410                 415     





Lys Lys Leu Asn Thr Gln 

            420         





<210>  23

<211>  168

<212>  PRT

<213>  Synthetic



<400>  23



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr Ser Asp Glu Leu Arg 

                85                  90                  95      





Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala 

            100                 105                 110         





Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu 

        115                 120                 125             





Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 

    130                 135                 140                 





Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu 

145                 150                 155                 160 





Tyr Thr Lys Lys Leu Asn Thr Gln 

                165             





<210>  24

<211>  168

<212>  PRT

<213>  Synthetic



<400>  24



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Ala 

            100                 105                 110         





Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu 

        115                 120                 125             





Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 

    130                 135                 140                 





Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu 

145                 150                 155                 160 





Tyr Thr Lys Lys Leu Asn Thr Gln 

                165             





<210>  25

<211>  201

<212>  PRT

<213>  Synthetic



<400>  25



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Val Thr Gln Glu Phe Trp Asp Asn 

            20                  25                  30          





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 

        35                  40                  45              





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    50                  55                  60                  





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu 

65                  70                  75                  80  





Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln 

                85                  90                  95      





Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala 

            100                 105                 110         





His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu 

        115                 120                 125             





Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly 

    130                 135                 140                 





Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr 

145                 150                 155                 160 





Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu 

                165                 170                 175     





Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu 

            180                 185                 190         





Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

        195                 200     





<210>  26

<211>  190

<212>  PRT

<213>  Synthetic



<400>  26



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Lys Glu Thr Glu Gly Leu Arg Gln Glu 

            20                  25                  30          





Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu 

        35                  40                  45              





Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln 

    50                  55                  60                  





Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys 

65                  70                  75                  80  





Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg 

                85                  90                  95      





Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro 

            100                 105                 110         





Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu 

        115                 120                 125             





Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr 

    130                 135                 140                 





Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp 

145                 150                 155                 160 





Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe 

                165                 170                 175     





Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

            180                 185                 190 





<210>  27

<211>  179

<212>  PRT

<213>  Synthetic



<400>  27



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Lys Asp Leu Glu Glu Val Lys Ala Lys 

            20                  25                  30          





Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 

        35                  40                  45              





Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 

    50                  55                  60                  





Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 

65                  70                  75                  80  





Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 

                85                  90                  95      





Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 

            100                 105                 110         





Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 

        115                 120                 125             





His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 

    130                 135                 140                 





Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 

145                 150                 155                 160 





Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 

                165                 170                 175     





Asn Thr Gln 

            





<210>  28

<211>  199

<212>  PRT

<213>  Synthetic



<400>  28



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Val Thr Gln Glu Phe Trp Asp Asn 

            20                  25                  30          





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 

        35                  40                  45              





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    50                  55                  60                  





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr 

65                  70                  75                  80  





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                85                  90                  95      





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            100                 105                 110         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        115                 120                 125             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    130                 135                 140                 





Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 

145                 150                 155                 160 





Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala 

                165                 170                 175     





Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu 

            180                 185                 190         





Asp Leu Arg Gln Gly Leu Leu 

        195                 





<210>  29

<211>  289

<212>  PRT

<213>  Synthetic



<400>  29



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Leu Lys Leu Leu Asp Asn Trp Asp Ser 

            20                  25                  30          





Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr 

        35                  40                  45              





Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln 

    50                  55                  60                  





Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr 

65                  70                  75                  80  





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                85                  90                  95      





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            100                 105                 110         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        115                 120                 125             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    130                 135                 140                 





Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu 

145                 150                 155                 160 





Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala 

                165                 170                 175     





Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu 

            180                 185                 190         





Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His 

        195                 200                 205             





Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu 

    210                 215                 220                 





Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala 

225                 230                 235                 240 





Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala 

                245                 250                 255     





Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys 

            260                 265                 270         





Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr 

        275                 280                 285             





Gln 

    





<210>  30

<211>  278

<212>  PRT

<213>  Synthetic



<400>  30



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln 

    130                 135                 140                 





Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu 

145                 150                 155                 160 





Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu 

                165                 170                 175     





Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp 

            180                 185                 190         





Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg 

        195                 200                 205             





Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu 

    210                 215                 220                 





Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu 

225                 230                 235                 240 





Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val 

                245                 250                 255     





Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr 

            260                 265                 270         





Lys Lys Leu Asn Thr Gln 

        275             





<210>  31

<211>  423

<212>  PRT

<213>  Synthetic



<400>  31



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Leu Lys Leu Leu Asp Asn Trp Asp Ser 

            20                  25                  30          





Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr 

        35                  40                  45              





Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln 

    50                  55                  60                  





Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr 

65                  70                  75                  80  





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                85                  90                  95      





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            100                 105                 110         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        115                 120                 125             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    130                 135                 140                 





Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 

145                 150                 155                 160 





Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala 

                165                 170                 175     





Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu 

            180                 185                 190         





Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser 

        195                 200                 205             





Phe Leu Ser Ala Leu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Gly Thr 

    210                 215                 220                 





Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys 

225                 230                 235                 240 





Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu 

                245                 250                 255     





Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Lys Asp Leu Glu Glu 

            260                 265                 270         





Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp 

        275                 280                 285             





Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala 

    290                 295                 300                 





Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys 

305                 310                 315                 320 





Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val 

                325                 330                 335     





Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln 

            340                 345                 350         





Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg 

        355                 360                 365             





Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser 

    370                 375                 380                 





Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro 

385                 390                 395                 400 





Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr 

                405                 410                 415     





Thr Lys Lys Leu Asn Thr Gln 

            420             





<210>  32

<211>  401

<212>  PRT

<213>  Synthetic



<400>  32



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro 

    210                 215                 220                 





Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu 

225                 230                 235                 240 





Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln 

                245                 250                 255     





Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu 

            260                 265                 270         





Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala 

        275                 280                 285             





Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu 

    290                 295                 300                 





Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His 

305                 310                 315                 320 





Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu 

                325                 330                 335     





Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala 

            340                 345                 350         





Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala 

        355                 360                 365             





Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys 

    370                 375                 380                 





Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr 

385                 390                 395                 400 





Gln 

    





<210>  33

<211>  392

<212>  PRT

<213>  Synthetic



<400>  33



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr Pro Val Thr Gln Glu Phe Trp Asp Asn Leu 

    210                 215                 220                 





Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu 

225                 230                 235                 240 





Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys 

                245                 250                 255     





Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg 

            260                 265                 270         





Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu 

        275                 280                 285             





Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His 

    290                 295                 300                 





Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg 

305                 310                 315                 320 





Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala 

                325                 330                 335     





Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu 

            340                 345                 350         





Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 

        355                 360                 365             





Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu 

    370                 375                 380                 





Tyr Thr Lys Lys Leu Asn Thr Gln 

385                 390         





<210>  34

<211>  397

<212>  PRT

<213>  Synthetic



<400>  34



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr Arg Glu Gln Leu Gly Pro Val Thr Gln Glu 

    210                 215                 220                 





Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met 

225                 230                 235                 240 





Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp 

                245                 250                 255     





Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 

            260                 265                 270         





Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 

        275                 280                 285             





His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 

    290                 295                 300                 





Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 

305                 310                 315                 320 





Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 

                325                 330                 335     





Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 

            340                 345                 350         





His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 

        355                 360                 365             





Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu 

    370                 375                 380                 





Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

385                 390                 395         





<210>  35

<211>  383

<212>  PRT

<213>  Synthetic



<400>  35



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Val Thr Gln Glu Phe Trp Asp Asn 

            20                  25                  30          





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 

        35                  40                  45              





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    50                  55                  60                  





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu 

65                  70                  75                  80  





Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln 

                85                  90                  95      





Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala 

            100                 105                 110         





His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu 

        115                 120                 125             





Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly 

    130                 135                 140                 





Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr 

145                 150                 155                 160 





Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu 

                165                 170                 175     





Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu 

            180                 185                 190         





Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asn Pro Gly Thr Pro Val Thr 

        195                 200                 205             





Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln 

    210                 215                 220                 





Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr 

225                 230                 235                 240 





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                245                 250                 255     





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            260                 265                 270         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        275                 280                 285             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    290                 295                 300                 





Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 

305                 310                 315                 320 





Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala 

                325                 330                 335     





Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu 

            340                 345                 350         





Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser 

        355                 360                 365             





Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 

    370                 375                 380             





<210>  36

<211>  379

<212>  PRT

<213>  Synthetic



<400>  36



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Val Thr Gln Glu Phe Trp Asp Asn 

            20                  25                  30          





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 

        35                  40                  45              





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    50                  55                  60                  





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr 

65                  70                  75                  80  





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                85                  90                  95      





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            100                 105                 110         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        115                 120                 125             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    130                 135                 140                 





Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 

145                 150                 155                 160 





Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala 

                165                 170                 175     





Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu 

            180                 185                 190         





Asp Leu Arg Gln Gly Leu Leu Asn Pro Gly Thr Lys Asp Leu Glu Glu 

        195                 200                 205             





Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp 

    210                 215                 220                 





Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr Leu Asp 

225                 230                 235                 240 





Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 

                245                 250                 255     





Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 

            260                 265                 270         





His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 

        275                 280                 285             





Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 

    290                 295                 300                 





Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 

305                 310                 315                 320 





Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 

                325                 330                 335     





His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 

            340                 345                 350         





Arg Gln Gly Leu Leu Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu 

        355                 360                 365             





Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser 

    370                 375                 





<210>  37

<211>  381

<212>  PRT

<213>  Synthetic



<400>  37



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Val Thr Gln Glu Phe Trp Asp Asn 

            20                  25                  30          





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu 

        35                  40                  45              





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    50                  55                  60                  





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr 

65                  70                  75                  80  





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                85                  90                  95      





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            100                 105                 110         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        115                 120                 125             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    130                 135                 140                 





Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 

145                 150                 155                 160 





Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala 

                165                 170                 175     





Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu 

            180                 185                 190         





Asp Leu Arg Gln Gly Leu Leu Ser Asn Pro Gly Thr Gln Lys Asp Leu 

        195                 200                 205             





Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys 

    210                 215                 220                 





Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Tyr 

225                 230                 235                 240 





Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg 

                245                 250                 255     





Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln 

            260                 265                 270         





Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met 

        275                 280                 285             





Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala 

    290                 295                 300                 





Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala 

305                 310                 315                 320 





Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala 

                325                 330                 335     





Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu 

            340                 345                 350         





Asp Leu Arg Gln Gly Leu Leu Pro Val Thr Gln Glu Phe Trp Asp Asn 

        355                 360                 365             





Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser 

    370                 375                 380     





<210>  38

<211>  1094

<212>  PRT

<213>  Synthetic



<400>  38



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr Leu Lys Leu Leu Asp Asn Trp Asp Ser Val 

    210                 215                 220                 





Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln 

225                 230                 235                 240 





Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu 

                245                 250                 255     





Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu 

            260                 265                 270         





Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln 

        275                 280                 285             





Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys 

    290                 295                 300                 





Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg 

305                 310                 315                 320 





Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro 

                325                 330                 335     





Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu 

            340                 345                 350         





Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr 

        355                 360                 365             





Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp 

    370                 375                 380                 





Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe 

385                 390                 395                 400 





Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Ser Thr 

                405                 410                 415     





Met Gly Asp Ser His Glu Asp Thr Ser Ala Thr Met Pro Glu Ala Val 

            420                 425                 430         





Ala Glu Glu Val Ser Leu Phe Ser Thr Thr Asp Met Val Leu Phe Ser 

        435                 440                 445             





Leu Ile Val Gly Val Leu Thr Tyr Trp Phe Ile Phe Arg Lys Lys Lys 

    450                 455                 460                 





Glu Glu Ile Pro Glu Phe Ser Lys Ile Gln Thr Thr Ala Pro Pro Val 

465                 470                 475                 480 





Lys Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly Arg Asn Ile 

                485                 490                 495     





Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu Phe Ala Asn 

            500                 505                 510         





Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly Met Ser Ala 

        515                 520                 525             





Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu Pro Glu Ile 

    530                 535                 540                 





Asp Lys Ser Leu Val Val Phe Cys Met Ala Thr Tyr Gly Glu Gly Asp 

545                 550                 555                 560 





Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln Glu Thr Asp 

                565                 570                 575     





Val Asp Leu Thr Gly Val Lys Phe Ala Val Phe Gly Leu Gly Asn Lys 

            580                 585                 590         





Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp Gln Arg Leu 

        595                 600                 605             





Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu Gly Asp Asp 

    610                 615                 620                 





Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu Gln Phe Trp 

625                 630                 635                 640 





Pro Ala Val Cys Glu Phe Phe Gly Val Glu Ala Thr Gly Glu Glu Ser 

                645                 650                 655     





Ser Ile Arg Gln Tyr Glu Leu Val Val His Glu Asp Met Asp Val Ala 

            660                 665                 670         





Lys Val Tyr Thr Gly Glu Met Gly Arg Leu Lys Ser Tyr Glu Asn Gln 

        675                 680                 685             





Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala Val Thr Ala 

    690                 695                 700                 





Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met His Leu Glu 

705                 710                 715                 720 





Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly Asp His Val 

                725                 730                 735     





Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn Gln Ile Gly Glu 

            740                 745                 750         





Ile Leu Gly Ala Asp Leu Asp Val Ile Met Ser Leu Asn Asn Leu Asp 

        755                 760                 765             





Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr Thr Tyr Arg 

    770                 775                 780                 





Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro Arg Thr Asn 

785                 790                 795                 800 





Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser Glu Gln Glu 

                805                 810                 815     





His Leu His Lys Met Ala Ser Ser Ser Gly Glu Gly Lys Glu Leu Tyr 

            820                 825                 830         





Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala Ile Leu Gln 

        835                 840                 845             





Asp Tyr Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys Glu Leu Leu 

    850                 855                 860                 





Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser Ser Lys Val 

865                 870                 875                 880 





His Pro Asn Ser Val His Ile Cys Ala Val Ala Val Glu Tyr Glu Ala 

                885                 890                 895     





Lys Ser Gly Arg Val Asn Lys Gly Val Ala Thr Ser Trp Leu Arg Ala 

            900                 905                 910         





Lys Glu Pro Ala Gly Glu Asn Gly Gly Arg Ala Leu Val Pro Met Phe 

        915                 920                 925             





Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ser Thr Thr Pro Val 

    930                 935                 940                 





Ile Met Val Gly Pro Gly Thr Gly Ile Ala Pro Phe Met Gly Phe Ile 

945                 950                 955                 960 





Gln Glu Arg Ala Trp Leu Arg Glu Gln Gly Lys Glu Val Gly Glu Thr 

                965                 970                 975     





Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr Leu Tyr Arg 

            980                 985                 990         





Glu Glu Leu Ala Arg Phe His Lys  Asp Gly Ala Leu Thr  Gln Leu Asn 

        995                 1000                 1005             





Val Ala  Phe Ser Arg Glu Gln  Ala His Lys Val Tyr  Val Gln His 

    1010                 1015                 1020             





Leu Leu  Lys Arg Asp Arg Glu  His Leu Trp Lys Leu  Ile His Glu 

    1025                 1030                 1035             





Gly Gly  Ala His Ile Tyr Val  Cys Gly Asp Ala Arg  Asn Met Ala 

    1040                 1045                 1050             





Lys Asp  Val Gln Asn Thr Phe  Tyr Asp Ile Val Ala  Glu Phe Gly 

    1055                 1060                 1065             





Pro Met  Glu His Thr Gln Ala  Val Asp Tyr Val Lys  Lys Leu Met 

    1070                 1075                 1080             





Thr Lys  Gly Arg Tyr Ser Leu  Asp Val Trp Ser 

    1085                 1090                 





<210>  39

<211>  214

<212>  PRT

<213>  Synthetic



<400>  39



Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 

1               5                   10                  15      





Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln Gly Thr 

    210                 





<210>  40

<211>  212

<212>  PRT

<213>  Synthetic 



<400>  40



Met Gly His His His His His His Ile Glu Gly Cys Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln 

    210         





<210>  41

<211>  212

<212>  PRT

<213>  Sythetic



<400>  41



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Cys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln 

    210         





<210>  42

<211>  212

<212>  PRT

<213>  Sythetic



<400>  42



Met Gly His His His His His His Ile Glu Gly Arg Leu Lys Leu Leu 

1               5                   10                  15      





Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln 

            20                  25                  30          





Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 

        35                  40                  45              





Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 

    50                  55                  60                  





Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 

65                  70                  75                  80  





Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 

                85                  90                  95      





Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 

            100                 105                 110         





Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 

        115                 120                 125             





Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 

    130                 135                 140                 





Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 

145                 150                 155                 160 





Tyr His Ala Cys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 

                165                 170                 175     





Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 

            180                 185                 190         





Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 

        195                 200                 205             





Leu Asn Thr Gln 

    210         





<210>  43

<211>  110

<212>  PRT

<213>  Escherichia coli 



<400>  43



Met Asn Pro Tyr Ile Tyr Leu Gly Gly Ala Ile Leu Ala Glu Val Ile 

1               5                   10                  15      





Gly Thr Thr Leu Met Lys Phe Ser Glu Gly Phe Thr Arg Leu Trp Pro 

            20                  25                  30          





Ser Val Gly Thr Ile Ile Cys Tyr Cys Ala Ser Phe Trp Leu Leu Ala 

        35                  40                  45              





Gln Thr Leu Ala Tyr Ile Pro Thr Gly Ile Ala Tyr Ala Ile Trp Ser 

    50                  55                  60                  





Gly Val Gly Ile Val Leu Ile Ser Leu Leu Ser Trp Gly Phe Phe Gly 

65                  70                  75                  80  





Gln Arg Leu Asp Leu Pro Ala Ile Ile Gly Met Met Leu Ile Cys Ala 

                85                  90                  95      





Gly Val Leu Ile Ile Asn Leu Leu Ser Arg Ser Thr Pro His 

            100                 105                 110 





<210>  44

<211>  262

<212>  PRT

<213>  Halobacteriun halobium



<400>  44



Met Leu Glu Leu Leu Pro Thr Ala Val Glu Gly Val Ser Gln Ala Gln 

1               5                   10                  15      





Ile Thr Gly Arg Pro Glu Trp Ile Trp Leu Ala Leu Gly Thr Ala Leu 

            20                  25                  30          





Met Gly Leu Gly Thr Leu Tyr Phe Leu Val Lys Gly Met Gly Val Ser 

        35                  40                  45              





Asp Pro Asp Ala Lys Lys Phe Tyr Ala Ile Thr Thr Leu Val Pro Ala 

    50                  55                  60                  





Ile Ala Phe Thr Met Tyr Leu Ser Met Leu Leu Gly Tyr Gly Leu Thr 

65                  70                  75                  80  





Met Val Pro Phe Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr 

                85                  90                  95      





Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu 

            100                 105                 110         





Leu Val Asp Ala Asp Gln Gly Thr Ile Leu Ala Leu Val Gly Ala Asp 

        115                 120                 125             





Gly Ile Met Ile Gly Thr Gly Leu Val Gly Ala Leu Thr Lys Val Tyr 

    130                 135                 140                 





Ser Tyr Arg Phe Val Trp Trp Ala Ile Ser Thr Ala Ala Met Leu Tyr 

145                 150                 155                 160 





Ile Leu Tyr Val Leu Phe Phe Gly Phe Thr Ser Lys Ala Glu Ser Met 

                165                 170                 175     





Arg Pro Glu Val Ala Ser Thr Phe Lys Val Leu Arg Asn Val Thr Val 

            180                 185                 190         





Val Leu Trp Ser Ala Tyr Pro Val Val Trp Leu Ile Gly Ser Glu Gly 

        195                 200                 205             





Ala Gly Ile Val Pro Leu Asn Ile Glu Thr Leu Leu Phe Met Val Leu 

    210                 215                 220                 





Asp Val Ser Ala Lys Val Gly Phe Gly Leu Ile Leu Leu Arg Ser Arg 

225                 230                 235                 240 





Ala Ile Phe Gly Glu Ala Glu Ala Pro Glu Pro Ser Ala Gly Asp Gly 

                245                 250                 255     





Ala Ala Ala Thr Ser Asp 

            260         





<210>  45

<211>  155

<212>  PRT

<213>  Homo sapiens



<400>  45



Met Gln Pro Ser Pro Pro Pro Thr Glu Leu Val Pro Ser Glu Arg Ala 

1               5                   10                  15      





Val Val Leu Leu Ser Cys Ala Leu Ser Ala Leu Gly Ser Gly Leu Leu 

            20                  25                  30          





Val Ala Thr His Ala Leu Trp Pro Asp Leu Arg Ser Arg Ala Arg Arg 

        35                  40                  45              





Leu Leu Leu Phe Leu Ser Leu Ala Asp Leu Leu Ser Ala Ala Ser Tyr 

    50                  55                  60                  





Phe Tyr Gly Val Leu Gln Asn Phe Ala Gly Pro Ser Trp Asp Cys Val 

65                  70                  75                  80  





Leu Gln Gly Ala Leu Ser Thr Phe Ala Asn Thr Ser Ser Phe Phe Trp 

                85                  90                  95      





Thr Val Ala Ile Ala Leu Tyr Leu Tyr Leu Ser Ile Val Arg Ala Ala 

            100                 105                 110         





Arg Gly Pro Arg Thr Asp Arg Leu Leu Trp Ala Phe His Val Val Arg 

        115                 120                 125             





Trp Val Ala Val Ala Leu Leu Phe Gln Glu Pro Pro Thr Gln Ala Asp 

    130                 135                 140                 





Pro Ser Arg Ser Cys Pro Pro Arg Gly Arg Val 

145                 150                 155 





<210>  46

<211>  486

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Arg Gly Arg Gly Ser Gln Gln Gln Gln Pro Thr Arg Arg Gln Gly 

1               5                   10                  15      





Gln Lys Leu Pro Ser Pro Ser Pro Ala Gly Lys Tyr Glu Ser Ala Gln 

            20                  25                  30          





Pro Gly Gly Thr Gln Pro Glu Pro Gly Leu Gly Ala Arg Met Ala Ile 

        35                  40                  45              





His Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe Leu Phe Pro 

    50                  55                  60                  





Gly Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser Gln Gly Leu 

65                  70                  75                  80  





Asn Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala Trp Gly Ile 

                85                  90                  95      





Val Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr Phe Val Leu 

            100                 105                 110         





Thr Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp Thr Lys Lys 

        115                 120                 125             





Arg Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly Thr Leu Gly 

    130                 135                 140                 





Leu Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp Phe Ser Thr 

145                 150                 155                 160 





Cys Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala Ile Cys Phe 

                165                 170                 175     





Ser Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu Ala Arg Lys 

            180                 185                 190         





Asn His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala Leu Leu Leu 

        195                 200                 205             





Thr Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile Ile Thr Leu 

    210                 215                 220                 





Val Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser Ser Ala Gly 

225                 230                 235                 240 





Trp Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp Phe Val Met 

                245                 250                 255     





Ala Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe Leu Gly Ala 

            260                 265                 270         





Trp Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys His Gly Val 

        275                 280                 285             





Phe Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp Val Val Trp 

    290                 295                 300                 





Ile Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser Pro Thr Trp 

305                 310                 315                 320 





Asp Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe 

                325                 330                 335     





Val Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr Lys Ser Ser 

            340                 345                 350         





Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly Val Gly 

        355                 360                 365             





Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe Val Glu 

    370                 375                 380                 





Asn Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg Pro Val 

385                 390                 395                 400 





Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln 

                405                 410                 415     





Pro Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly Ala Tyr 

            420                 425                 430         





Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser 

        435                 440                 445             





Ala Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln Ser His 

    450                 455                 460                 





Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val Phe Arg 

465                 470                 475                 480 





Asn Pro Tyr Val Trp Asp 

                485     





<210>  47

<211>  422

<212>  PRT

<213>  Homo sapiens



<400>  47



Met Asp Val Leu Ser Pro Gly Gln Gly Asn Asn Thr Thr Ser Pro Pro 

1               5                   10                  15      





Ala Pro Phe Glu Thr Gly Gly Asn Thr Thr Gly Ile Ser Asp Val Thr 

            20                  25                  30          





Val Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 

        35                  40                  45              





Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 

    50                  55                  60                  





Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 

65                  70                  75                  80  





Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 

                85                  90                  95      





Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 

            100                 105                 110         





Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 

        115                 120                 125             





Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 

    130                 135                 140                 





Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 

145                 150                 155                 160 





Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 

                165                 170                 175     





Thr Pro Glu Asp Arg Ser Asp Pro Asp Ala Cys Thr Ile Ser Lys Asp 

            180                 185                 190         





His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 

        195                 200                 205             





Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 

    210                 215                 220                 





Arg Ile Arg Lys Thr Val Lys Lys Val Glu Lys Thr Gly Ala Asp Thr 

225                 230                 235                 240 





Arg His Gly Ala Ser Pro Ala Pro Gln Pro Lys Lys Ser Val Asn Gly 

                245                 250                 255     





Glu Ser Gly Ser Arg Asn Trp Arg Leu Gly Val Glu Ser Lys Ala Gly 

            260                 265                 270         





Gly Ala Leu Cys Ala Asn Gly Ala Val Arg Gln Gly Asp Asp Gly Ala 

        275                 280                 285             





Ala Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Glu His 

    290                 295                 300                 





Leu Pro Leu Pro Ser Glu Ala Gly Pro Thr Pro Cys Ala Pro Ala Ser 

305                 310                 315                 320 





Phe Glu Arg Lys Asn Glu Arg Asn Ala Glu Ala Lys Arg Lys Met Ala 

                325                 330                 335     





Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 

            340                 345                 350         





Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 

        355                 360                 365             





Pro Phe Cys Glu Ser Ser Cys His Met Pro Thr Leu Leu Gly Ala Ile 

    370                 375                 380                 





Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 

385                 390                 395                 400 





Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 

                405                 410                 415     





Cys Lys Phe Cys Arg Gln 

            420         





<210>  48

<211>  442

<212>  PRT

<213>  Homo sapiens



<400>  48



Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 

1               5                   10                  15      





Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 

            20                  25                  30          





Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 

        35                  40                  45              





Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 

    50                  55                  60                  





Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 

65                  70                  75                  80  





Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 

                85                  90                  95      





Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 

            100                 105                 110         





Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 

        115                 120                 125             





Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 

    130                 135                 140                 





Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 

145                 150                 155                 160 





Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 

                165                 170                 175     





Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 

            180                 185                 190         





Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 

        195                 200                 205             





Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 

    210                 215                 220                 





Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 

225                 230                 235                 240 





Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 

                245                 250                 255     





Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 

            260                 265                 270         





Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 

        275                 280                 285             





Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 

    290                 295                 300                 





Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 

305                 310                 315                 320 





Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 

                325                 330                 335     





Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 

            340                 345                 350         





Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 

        355                 360                 365             





Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 

    370                 375                 380                 





Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 

385                 390                 395                 400 





Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 

                405                 410                 415     





Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 

            420                 425                 430         





Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 

        435                 440         





<210>  49

<211>  370

<212>  PRT

<213>  Homo sapiens



<400>  49



Met Glu Pro Leu Phe Pro Ala Pro Phe Trp Glu Val Ile Tyr Gly Ser 

1               5                   10                  15      





His Leu Gln Gly Asn Leu Ser Leu Leu Ser Pro Asn His Ser Leu Leu 

            20                  25                  30          





Pro Pro His Leu Leu Leu Asn Ala Ser His Gly Ala Phe Leu Pro Leu 

        35                  40                  45              





Gly Leu Lys Val Thr Ile Val Gly Leu Tyr Leu Ala Val Cys Val Gly 

    50                  55                  60                  





Gly Leu Leu Gly Asn Cys Leu Val Met Tyr Val Ile Leu Arg His Thr 

65                  70                  75                  80  





Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 

                85                  90                  95      





Asp Thr Leu Val Leu Leu Thr Leu Pro Phe Gln Gly Thr Asp Ile Leu 

            100                 105                 110         





Leu Gly Phe Trp Pro Phe Gly Asn Ala Leu Cys Lys Thr Val Ile Ala 

        115                 120                 125             





Ile Asp Tyr Tyr Asn Met Phe Thr Ser Thr Phe Thr Leu Thr Ala Met 

    130                 135                 140                 





Ser Val Asp Arg Tyr Val Ala Ile Cys His Pro Ile Arg Ala Leu Asp 

145                 150                 155                 160 





Val Arg Thr Ser Ser Lys Ala Gln Ala Val Asn Val Ala Ile Trp Ala 

                165                 170                 175     





Leu Ala Ser Val Val Gly Val Pro Val Ala Ile Met Gly Ser Ala Gln 

            180                 185                 190         





Val Glu Asp Glu Glu Ile Glu Cys Leu Val Glu Ile Pro Thr Pro Gln 

        195                 200                 205             





Asp Tyr Trp Gly Pro Val Phe Ala Ile Cys Ile Phe Leu Phe Ser Phe 

    210                 215                 220                 





Ile Val Pro Val Leu Val Ile Ser Val Cys Tyr Ser Leu Met Ile Arg 

225                 230                 235                 240 





Arg Leu Arg Gly Val Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg 

                245                 250                 255     





Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val Ala Val Phe 

            260                 265                 270         





Val Gly Cys Trp Thr Pro Val Gln Val Phe Val Leu Ala Gln Gly Leu 

        275                 280                 285             





Gly Val Gln Pro Ser Ser Glu Thr Ala Val Ala Ile Leu Arg Phe Cys 

    290                 295                 300                 





Thr Ala Leu Gly Tyr Val Asn Ser Cys Leu Asn Pro Ile Leu Tyr Ala 

305                 310                 315                 320 





Phe Leu Asp Glu Asn Phe Lys Ala Cys Phe Arg Lys Phe Cys Cys Ala 

                325                 330                 335     





Ser Ala Leu Arg Arg Asp Val Gln Val Ser Asp Arg Val Arg Ser Ile 

            340                 345                 350         





Ala Lys Asp Val Ala Leu Ala Cys Lys Thr Ser Glu Thr Val Pro Arg 

        355                 360                 365             





Pro Ala 

    370 





<210>  50

<211>  466

<212>  PRT

<213>  Homo sapiens



<400>  50



Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 

1               5                   10                  15      





Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 

            20                  25                  30          





Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 

        35                  40                  45              





Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 

    50                  55                  60                  





Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 

65                  70                  75                  80  





Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 

                85                  90                  95      





Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 

            100                 105                 110         





Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 

        115                 120                 125             





Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 

    130                 135                 140                 





Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 

145                 150                 155                 160 





Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 

                165                 170                 175     





Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 

            180                 185                 190         





Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 

        195                 200                 205             





Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 

    210                 215                 220                 





Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 

225                 230                 235                 240 





Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 

                245                 250                 255     





His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 

            260                 265                 270         





Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 

        275                 280                 285             





Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 

    290                 295                 300                 





Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 

305                 310                 315                 320 





Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 

                325                 330                 335     





Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 

            340                 345                 350         





Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 

        355                 360                 365             





Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 

    370                 375                 380                 





Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 

385                 390                 395                 400 





Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 

                405                 410                 415     





Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 

            420                 425                 430         





Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 

        435                 440                 445             





Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 

    450                 455                 460                 





Thr Arg 

465     





<210>  51

<211>  397

<212>  PRT

<213>  Homo sapiens



<400>  51



Met Ala Pro Asn Gly Thr Ala Ser Ser Phe Cys Leu Asp Ser Thr Ala 

1               5                   10                  15      





Cys Lys Ile Thr Ile Thr Val Val Leu Ala Val Leu Ile Leu Ile Thr 

            20                  25                  30          





Val Ala Gly Asn Val Val Val Cys Leu Ala Val Gly Leu Asn Arg Arg 

        35                  40                  45              





Leu Arg Asn Leu Thr Asn Cys Phe Ile Val Ser Leu Ala Ile Thr Asp 

    50                  55                  60                  





Leu Leu Leu Gly Leu Leu Val Leu Pro Phe Ser Ala Ile Tyr Gln Leu 

65                  70                  75                  80  





Ser Cys Lys Trp Ser Phe Gly Lys Val Phe Cys Asn Ile Tyr Thr Ser 

                85                  90                  95      





Leu Asp Val Met Leu Cys Thr Ala Ser Ile Leu Asn Leu Phe Met Ile 

            100                 105                 110         





Ser Leu Asp Arg Tyr Cys Ala Val Met Asp Pro Leu Arg Tyr Pro Val 

        115                 120                 125             





Leu Val Thr Pro Val Arg Val Ala Ile Ser Leu Val Leu Ile Trp Val 

    130                 135                 140                 





Ile Ser Ile Thr Leu Ser Phe Leu Ser Ile His Leu Gly Trp Asn Ser 

145                 150                 155                 160 





Arg Asn Glu Thr Ser Lys Gly Asn His Thr Thr Ser Lys Cys Lys Val 

                165                 170                 175     





Gln Val Asn Glu Val Tyr Gly Leu Val Asp Gly Leu Val Thr Phe Tyr 

            180                 185                 190         





Leu Pro Leu Leu Ile Met Cys Ile Thr Tyr Tyr Arg Ile Phe Lys Val 

        195                 200                 205             





Ala Arg Asp Gln Ala Lys Arg Ile Asn His Ile Ser Ser Trp Lys Ala 

    210                 215                 220                 





Ala Thr Ile Arg Glu His Lys Ala Thr Val Thr Leu Ala Ala Val Met 

225                 230                 235                 240 





Gly Ala Phe Ile Ile Cys Trp Phe Pro Tyr Phe Thr Ala Phe Val Tyr 

                245                 250                 255     





Arg Gly Leu Arg Gly Asp Asp Ala Ile Asn Glu Val Leu Glu Ala Ile 

            260                 265                 270         





Val Leu Trp Leu Gly Tyr Ala Asn Ser Ala Leu Asn Pro Ile Leu Tyr 

        275                 280                 285             





Ala Ala Leu Asn Arg Asp Phe Arg Thr Gly Tyr Gln Gln Leu Phe Cys 

    290                 295                 300                 





Cys Arg Leu Ala Asn Arg Asn Ser His Lys Thr Ser Leu Arg Ser Asn 

305                 310                 315                 320 





Ala Ser Gln Leu Ser Arg Thr Gln Ser Arg Glu Pro Arg Gln Gln Glu 

                325                 330                 335     





Glu Lys Pro Leu Lys Leu Gln Val Trp Ser Gly Thr Glu Val Thr Ala 

            340                 345                 350         





Pro Gln Gly Ala Thr Asp Arg Pro Trp Leu Cys Leu Pro Glu Cys Trp 

        355                 360                 365             





Ser Val Glu Leu Thr His Ser Phe Ile His Leu Phe Ile His Ser Phe 

    370                 375                 380                 





Ala Asn Ile His Pro Ile Pro Thr Thr Cys Gln Glu Leu 

385                 390                 395         





<210>  52

<211>  446

<212>  PRT

<213>  Homo sapiens



<400>  52



Met Arg Thr Leu Asn Thr Ser Ala Met Asp Gly Thr Gly Leu Val Val 

1               5                   10                  15      





Glu Arg Asp Phe Ser Val Arg Ile Leu Thr Ala Cys Phe Leu Ser Leu 

            20                  25                  30          





Leu Ile Leu Ser Thr Leu Leu Gly Asn Thr Leu Val Cys Ala Ala Val 

        35                  40                  45              





Ile Arg Phe Arg His Leu Arg Ser Lys Val Thr Asn Phe Phe Val Ile 

    50                  55                  60                  





Ser Leu Ala Val Ser Asp Leu Leu Val Ala Val Leu Val Met Pro Trp 

65                  70                  75                  80  





Lys Ala Val Ala Glu Ile Ala Gly Phe Trp Pro Phe Gly Ser Phe Cys 

                85                  90                  95      





Asn Ile Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile Leu 

            100                 105                 110         





Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Ser Pro 

        115                 120                 125             





Phe Arg Tyr Glu Arg Lys Met Thr Pro Lys Ala Ala Phe Ile Leu Ile 

    130                 135                 140                 





Ser Val Ala Trp Thr Leu Ser Val Leu Ile Ser Phe Ile Pro Val Gln 

145                 150                 155                 160 





Leu Ser Trp His Lys Ala Lys Pro Thr Ser Pro Ser Asp Gly Asn Ala 

                165                 170                 175     





Thr Ser Leu Ala Glu Thr Ile Asp Asn Cys Asp Ser Ser Leu Ser Arg 

            180                 185                 190         





Thr Tyr Ala Ile Ser Ser Ser Val Ile Ser Phe Tyr Ile Pro Val Ala 

        195                 200                 205             





Ile Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Lys Gln 

    210                 215                 220                 





Ile Arg Arg Ile Ala Ala Leu Glu Arg Ala Ala Val His Ala Lys Asn 

225                 230                 235                 240 





Cys Gln Thr Thr Thr Gly Asn Gly Lys Pro Val Glu Cys Ser Gln Pro 

                245                 250                 255     





Glu Ser Ser Phe Lys Met Ser Phe Lys Arg Glu Thr Lys Val Leu Lys 

            260                 265                 270         





Thr Leu Ser Val Ile Met Gly Val Phe Val Cys Cys Trp Leu Pro Phe 

        275                 280                 285             





Phe Ile Leu Asn Cys Ile Leu Pro Phe Cys Gly Ser Gly Glu Thr Gln 

    290                 295                 300                 





Pro Phe Cys Ile Asp Ser Asn Thr Phe Asp Val Phe Val Trp Phe Gly 

305                 310                 315                 320 





Trp Ala Asn Ser Ser Leu Asn Pro Ile Ile Tyr Ala Phe Asn Ala Asp 

                325                 330                 335     





Phe Arg Lys Ala Phe Ser Thr Leu Leu Gly Cys Tyr Arg Leu Cys Pro 

            340                 345                 350         





Ala Thr Asn Asn Ala Ile Glu Thr Val Ser Ile Asn Asn Asn Gly Ala 

        355                 360                 365             





Ala Met Phe Ser Ser His His Glu Pro Arg Gly Ser Ile Ser Lys Glu 

    370                 375                 380                 





Cys Asn Leu Val Tyr Leu Ile Pro His Ala Val Gly Ser Ser Glu Asp 

385                 390                 395                 400 





Leu Lys Lys Glu Glu Ala Ala Gly Ile Ala Arg Pro Leu Glu Lys Leu 

                405                 410                 415     





Ser Pro Ala Leu Ser Val Ile Leu Asp Tyr Asp Thr Asp Val Ser Leu 

            420                 425                 430         





Glu Lys Ile Gln Pro Ile Thr Gln Asn Gly Gln His Pro Thr 

        435                 440                 445     





<210>  53

<211>  325

<212>  PRT

<213>  Homo sapiens



<400>  53



Met Asn Ser Ser Phe His Leu His Phe Leu Asp Leu Asn Leu Asn Ala 

1               5                   10                  15      





Thr Glu Gly Asn Leu Ser Gly Pro Asn Val Lys Asn Lys Ser Ser Pro 

            20                  25                  30          





Cys Glu Asp Met Gly Ile Ala Val Glu Val Phe Leu Thr Leu Gly Val 

        35                  40                  45              





Ile Ser Leu Leu Glu Asn Ile Leu Val Ile Gly Ala Ile Val Lys Asn 

    50                  55                  60                  





Lys Asn Leu His Ser Pro Met Tyr Phe Phe Val Cys Ser Leu Ala Val 

65                  70                  75                  80  





Ala Asp Met Leu Val Ser Met Ser Ser Ala Trp Glu Thr Ile Thr Ile 

                85                  90                  95      





Tyr Leu Leu Asn Asn Lys His Leu Val Ile Ala Asp Ala Phe Val Arg 

            100                 105                 110         





His Ile Asp Asn Val Phe Asp Ser Met Ile Cys Ile Ser Val Val Ala 

        115                 120                 125             





Ser Met Cys Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Val Thr Ile 

    130                 135                 140                 





Phe Tyr Ala Leu Arg Tyr His His Ile Met Thr Ala Arg Arg Ser Gly 

145                 150                 155                 160 





Ala Ile Ile Ala Gly Ile Trp Ala Phe Cys Thr Gly Cys Gly Ile Val 

                165                 170                 175     





Phe Ile Leu Tyr Ser Glu Ser Thr Tyr Val Ile Leu Cys Leu Ile Ser 

            180                 185                 190         





Met Phe Phe Ala Met Leu Phe Leu Leu Val Ser Leu Tyr Ile His Met 

        195                 200                 205             





Phe Leu Leu Ala Arg Thr His Val Lys Arg Ile Ala Ala Leu Pro Gly 

    210                 215                 220                 





Ala Ser Ser Ala Arg Gln Arg Thr Ser Met Gln Gly Ala Val Thr Val 

225                 230                 235                 240 





Thr Met Leu Leu Gly Val Phe Thr Val Cys Trp Ala Pro Phe Phe Leu 

                245                 250                 255     





His Leu Thr Leu Met Leu Ser Cys Pro Gln Asn Leu Tyr Cys Ser Arg 

            260                 265                 270         





Phe Met Ser His Phe Asn Met Tyr Leu Ile Leu Ile Met Cys Asn Ser 

        275                 280                 285             





Val Met Asp Pro Leu Ile Tyr Ala Phe Arg Ser Gln Glu Met Arg Lys 

    290                 295                 300                 





Thr Phe Lys Glu Ile Ile Cys Cys Arg Gly Phe Arg Ile Ala Cys Ser 

305                 310                 315                 320 





Phe Pro Arg Arg Asp 

                325 





<210>  54

<211>  415

<212>  PRT

<213>  Homo sapiens



<400>  54



Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 

1               5                   10                  15      





Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 

            20                  25                  30          





Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 

        35                  40                  45              





Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 

    50                  55                  60                  





Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 

65                  70                  75                  80  





Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 

                85                  90                  95      





Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 

            100                 105                 110         





Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 

        115                 120                 125             





Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 

    130                 135                 140                 





Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 

145                 150                 155                 160 





Ala Phe Ile Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met 

                165                 170                 175     





Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr 

            180                 185                 190         





Ala Ala Tyr Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly 

        195                 200                 205             





Glu Gly Cys Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp 

    210                 215                 220                 





Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 

225                 230                 235                 240 





Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 

                245                 250                 255     





Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 

            260                 265                 270         





Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 

        275                 280                 285             





Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 

    290                 295                 300                 





Glu Thr Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu 

305                 310                 315                 320 





Pro Leu Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 

                325                 330                 335     





Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 

            340                 345                 350         





Ser Phe Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser 

        355                 360                 365             





Glu Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys 

    370                 375                 380                 





His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser 

385                 390                 395                 400 





Pro Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 

                405                 410                 415 





<210>  55

<211>  422

<212>  PRT

<213>  Homo sapiens



<400>  55



Met Asp Val Leu Ser Pro Gly Gln Gly Asn Asn Thr Thr Ser Pro Pro 

1               5                   10                  15      





Ala Pro Phe Glu Thr Gly Gly Asn Thr Thr Gly Ile Ser Asp Val Thr 

            20                  25                  30          





Val Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 

        35                  40                  45              





Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 

    50                  55                  60                  





Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 

65                  70                  75                  80  





Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 

                85                  90                  95      





Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 

            100                 105                 110         





Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 

        115                 120                 125             





Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 

    130                 135                 140                 





Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 

145                 150                 155                 160 





Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 

                165                 170                 175     





Thr Pro Glu Asp Arg Ser Asp Pro Asp Ala Cys Thr Ile Ser Lys Asp 

            180                 185                 190         





His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 

        195                 200                 205             





Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 

    210                 215                 220                 





Arg Ile Arg Lys Thr Val Lys Lys Val Glu Lys Thr Gly Ala Asp Thr 

225                 230                 235                 240 





Arg His Gly Ala Ser Pro Ala Pro Gln Pro Lys Lys Ser Val Asn Gly 

                245                 250                 255     





Glu Ser Gly Ser Arg Asn Trp Arg Leu Gly Val Glu Ser Lys Ala Gly 

            260                 265                 270         





Gly Ala Leu Cys Ala Asn Gly Ala Val Arg Gln Gly Asp Asp Gly Ala 

        275                 280                 285             





Ala Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Glu His 

    290                 295                 300                 





Leu Pro Leu Pro Ser Glu Ala Gly Pro Thr Pro Cys Ala Pro Ala Ser 

305                 310                 315                 320 





Phe Glu Arg Lys Asn Glu Arg Asn Ala Glu Ala Lys Arg Lys Met Ala 

                325                 330                 335     





Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 

            340                 345                 350         





Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 

        355                 360                 365             





Pro Phe Cys Glu Ser Ser Cys His Met Pro Thr Leu Leu Gly Ala Ile 

    370                 375                 380                 





Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 

385                 390                 395                 400 





Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 

                405                 410                 415     





Cys Lys Phe Cys Arg Gln 

            420         





<210>  56

<211>  460

<212>  PRT

<213>  Homo sapiens



<400>  56



Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu 

1               5                   10                  15      





Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr 

            20                  25                  30          





Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile 

        35                  40                  45              





Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu 

    50                  55                  60                  





Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn 

65                  70                  75                  80  





Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu 

                85                  90                  95      





Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 

            100                 105                 110         





Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr 

        115                 120                 125             





Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu 

    130                 135                 140                 





Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 

145                 150                 155                 160 





Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly 

                165                 170                 175     





Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr 

            180                 185                 190         





Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr 

        195                 200                 205             





Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala 

    210                 215                 220                 





Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 

225                 230                 235                 240 





Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro 

                245                 250                 255     





Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 

            260                 265                 270         





Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 

        275                 280                 285             





Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 

    290                 295                 300                 





Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg 

305                 310                 315                 320 





Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg 

                325                 330                 335     





Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 

            340                 345                 350         





Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser 

        355                 360                 365             





Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met 

    370                 375                 380                 





Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp 

385                 390                 395                 400 





Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met 

                405                 410                 415     





Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu 

            420                 425                 430         





Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 

        435                 440                 445             





Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys 

    450                 455                 460 





<210>  57

<211>  80

<212>  PRT

<213>  Homo sapiens



<400>  57



Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 

1               5                   10                  15      





Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 

            20                  25                  30          





Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 

        35                  40                  45              





Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 

    50                  55                  60                  





Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 

65                  70                  75                  80  





<210>  58

<211>  78

<212>  PRT

<213>  Homo sapiens



<400>  58



Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Ile Val Ser 

1               5                   10                  15      





Ile Ser Ala Ser Ser Thr Thr Gly Val Ala Met His Thr Ser Thr Ser 

            20                  25                  30          





Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Ile Thr 

        35                  40                  45              





Leu Ile Asn Trp Trp Ala Met Ala Arg Val Ile Phe Glu Val Met Leu 

    50                  55                  60                  





Val Val Val Gly Met Ile Ile Leu Ile Ser Tyr Cys Ile Arg 

65                  70                  75              





<210>  59

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  59



Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 

1               5                   10                  15      





Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 

            20                  25                  30          





Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Glu Thr 

        35                  40                  45              





Gly Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile 

    50                  55                  60                  





Leu Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu 

65                  70                  75                  80  





Ile Ser Tyr Ser Ile Arg Arg Leu Ile Lys Ala 

                85                  90      





<210>  60

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  60



Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 

1               5                   10                  15      





Val Lys Gly His Val Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu 

            20                  25                  30          





Val Thr Thr Val Phe Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro 

        35                  40                  45              





Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr 

    50                  55                  60                  





Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu 

65                  70                  75                  80  





Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys 

                85                  90                  95      





Glu Val Leu 

            





<210>  61

<211>  150

<212>  PRT

<213>  Homo sapiens



<400>  61



Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Ala Ile Val Ser 

1               5                   10                  15      





Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 

            20                  25                  30          





Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 

        35                  40                  45              





Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 

    50                  55                  60                  





Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 

65                  70                  75                  80  





Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 

                85                  90                  95      





Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 

            100                 105                 110         





Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 

        115                 120                 125             





Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 

    130                 135                 140                 





Pro Glu Thr Ser Asp Gln 

145                 150 





<210>  62

<211>  155

<212>  PRT

<213>  Mus musculus



<400>  62



Met Ala Asp Leu Arg Gln Leu Met Asp Asn Glu Val Leu Met Ala Phe 

1               5                   10                  15      





Thr Ser Tyr Ala Thr Ile Ile Leu Thr Lys Met Met Phe Met Ser Ser 

            20                  25                  30          





Ala Thr Ala Phe Gln Arg Ile Thr Asn Lys Val Phe Ala Asn Pro Glu 

        35                  40                  45              





Asp Cys Ala Gly Phe Gly Lys Val Glu Asn Ala Lys Lys Phe Val Arg 

    50                  55                  60                  





Thr Asp Glu Lys Val Glu Arg Val Arg Arg Ala His Leu Asn Asp Leu 

65                  70                  75                  80  





Glu Asn Ile Val Pro Phe Leu Gly Ile Gly Leu Leu Tyr Ser Leu Ser 

                85                  90                  95      





Gly Pro Asp Leu Ser Thr Ala Leu Met His Phe Arg Ile Phe Val Gly 

            100                 105                 110         





Ala Arg Ile Tyr His Thr Ile Ala Tyr Leu Thr Pro Leu Pro Gln Pro 

        115                 120                 125             





Asn Arg Gly Leu Ala Phe Phe Val Gly Tyr Gly Val Thr Leu Ser Met 

    130                 135                 140                 





Ala Tyr Arg Leu Leu Arg Ser Arg Leu Tyr Leu 

145                 150                 155 





<210>  63

<211>  158

<212>  PRT

<213>  Homo sapiens



<400>  63



Met Val Pro Arg Ser Thr Ser Leu Thr Leu Ile Val Phe Leu Phe His 

1               5                   10                  15      





Arg Leu Ser Lys Ala Pro Gly Lys Met Val Glu Asn Ser Pro Ser Pro 

            20                  25                  30          





Leu Pro Glu Arg Ala Ile Tyr Gly Phe Val Leu Phe Leu Ser Ser Gln 

        35                  40                  45              





Phe Gly Phe Ile Leu Tyr Leu Val Trp Ala Phe Ile Pro Glu Ser Trp 

    50                  55                  60                  





Leu Asn Ser Leu Gly Leu Thr Tyr Trp Pro Gln Lys Tyr Trp Ala Val 

65                  70                  75                  80  





Ala Leu Pro Val Tyr Leu Leu Ile Ala Ile Val Ile Gly Tyr Val Leu 

                85                  90                  95      





Leu Phe Gly Ile Asn Met Met Ser Thr Ser Pro Leu Asp Ser Ile His 

            100                 105                 110         





Thr Ile Thr Asp Asn Tyr Ala Lys Asn Gln Gln Gln Lys Lys Tyr Gln 

        115                 120                 125             





Glu Glu Ala Ile Pro Ala Leu Arg Asp Ile Ser Ile Ser Glu Val Asn 

    130                 135                 140                 





Gln Met Phe Phe Leu Ala Ala Lys Glu Leu Tyr Thr Lys Asn 

145                 150                 155             





<210>  64

<211>  162

<212>  PRT

<213>  Homo sapiens



<400>  64



Met Glu Thr Leu Pro Ala Ser Trp Val Leu Thr Leu Leu Cys Leu Gly 

1               5                   10                  15      





Ser His Leu Leu Gln Ala Val Ile Ser Thr Thr Val Ile Pro Ser Cys 

            20                  25                  30          





Ile Pro Gly Glu Ser Glu Asp Asn Cys Thr Ala Leu Val Gln Met Glu 

        35                  40                  45              





Asp Asp Pro Arg Val Ala Gln Val Gln Ile Thr Lys Cys Ser Ser Asp 

    50                  55                  60                  





Met Asp Gly Tyr Cys Leu His Gly Gln Cys Ile Tyr Leu Val Asp Met 

65                  70                  75                  80  





Arg Glu Lys Phe Cys Arg Cys Glu Val Gly Tyr Thr Gly Leu Arg Cys 

                85                  90                  95      





Glu His Phe Phe Leu Thr Val His Gln Pro Leu Ser Lys Glu Tyr Val 

            100                 105                 110         





Ala Leu Thr Val Ile Leu Ile Phe Leu Phe Leu Ile Ile Thr Ala Gly 

        115                 120                 125             





Cys Ile Tyr Tyr Phe Cys Arg Trp Tyr Lys Asn Arg Lys Ser Lys Lys 

    130                 135                 140                 





Ser Arg Glu Glu Tyr Glu Arg Val Thr Ser Gly Asp Pro Val Leu Pro 

145                 150                 155                 160 





Gln Val 

        





<210>  65

<211>  169

<212>  PRT

<213>  Homo sapiens



<400>  65



Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 

1               5                   10                  15      





Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 

            20                  25                  30          





Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 

        35                  40                  45              





Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 

    50                  55                  60                  





Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 

65                  70                  75                  80  





Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 

                85                  90                  95      





Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 

            100                 105                 110         





Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 

        115                 120                 125             





Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 

    130                 135                 140                 





Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 

145                 150                 155                 160 





Ser Gly Asp Pro Glu Leu Pro Gln Val 

                165                 





<210>  66

<211>  185

<212>  PRT

<213>  Homo sapiens



<400>  66



Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 

1               5                   10                  15      





Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 

            20                  25                  30          





Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 

        35                  40                  45              





Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 

    50                  55                  60                  





Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 

65                  70                  75                  80  





Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 

                85                  90                  95      





Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 

            100                 105                 110         





Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 

        115                 120                 125             





Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 

    130                 135                 140                 





Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 

145                 150                 155                 160 





Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 

                165                 170                 175     





Ala Val Gln Arg Thr Leu Leu Glu Lys 

            180                 185 





<210>  67

<211>  176

<212>  PRT

<213>  Mus musculus



<400>  67



Met Ala Leu Trp Arg Ala Tyr Gln Arg Ala Leu Ala Ala His Pro Trp 

1               5                   10                  15      





Lys Val Gln Val Leu Thr Ala Gly Ser Leu Met Gly Val Gly Asp Met 

            20                  25                  30          





Ile Ser Gln Gln Leu Val Glu Arg Arg Gly Leu Gln Gln His Gln Ala 

        35                  40                  45              





Gly Arg Thr Leu Thr Met Val Ser Leu Gly Cys Gly Phe Val Gly Pro 

    50                  55                  60                  





Val Val Gly Gly Trp Tyr Lys Val Leu Asp His Leu Ile Pro Gly Thr 

65                  70                  75                  80  





Thr Lys Val His Ala Leu Lys Lys Met Leu Leu Asp Gln Gly Gly Phe 

                85                  90                  95      





Ala Pro Cys Phe Leu Gly Cys Phe Leu Pro Leu Val Gly Ile Leu Asn 

            100                 105                 110         





Gly Met Ser Ala Gln Asp Asn Trp Ala Lys Leu Lys Arg Asp Tyr Pro 

        115                 120                 125             





Asp Ala Leu Ile Thr Asn Tyr Tyr Leu Trp Pro Ala Val Gln Leu Ala 

    130                 135                 140                 





Asn Phe Tyr Leu Val Pro Leu His Tyr Arg Leu Ala Val Val Gln Cys 

145                 150                 155                 160 





Val Ala Ile Val Trp Asn Ser Tyr Leu Ser Trp Lys Ala His Gln Phe 

                165                 170                 175     





<210>  68

<211>  176

<212>  PRT

<213>  Mus musculus



<400>  68



Met Ala Leu Trp Arg Ala Tyr Gln Arg Ala Leu Ala Ala His Pro Trp 

1               5                   10                  15      





Lys Val Gln Val Leu Thr Ala Gly Ser Leu Met Gly Leu Gly Asp Ile 

            20                  25                  30          





Ile Ser Gln Gln Leu Val Glu Arg Arg Gly Leu Gln Glu His Gln Arg 

        35                  40                  45              





Gly Arg Thr Leu Thr Met Val Ser Leu Gly Cys Gly Phe Val Gly Pro 

    50                  55                  60                  





Val Val Gly Gly Trp Tyr Lys Val Leu Asp Arg Phe Ile Pro Gly Thr 

65                  70                  75                  80  





Thr Lys Val Asp Ala Leu Lys Lys Met Leu Leu Asp Gln Gly Gly Phe 

                85                  90                  95      





Ala Pro Cys Phe Leu Gly Cys Phe Leu Pro Leu Val Gly Ala Leu Asn 

            100                 105                 110         





Gly Leu Ser Ala Gln Asp Asn Trp Ala Lys Leu Gln Arg Asp Tyr Pro 

        115                 120                 125             





Asp Ala Leu Ile Thr Asn Tyr Tyr Leu Trp Pro Ala Val Gln Leu Ala 

    130                 135                 140                 





Asn Phe Tyr Leu Val Pro Leu His Tyr Arg Leu Ala Val Val Gln Cys 

145                 150                 155                 160 





Val Ala Val Ile Trp Asn Ser Tyr Leu Ser Trp Lys Ala His Arg Leu 

                165                 170                 175     





<210>  69

<211>  194

<212>  PRT

<213>  Homo sapiens



<400>  69



Met Ala Ala Ala Ala Pro Asn Ala Gly Gly Ser Ala Pro Glu Thr Ala 

1               5                   10                  15      





Gly Ser Ala Glu Ala Pro Leu Gln Tyr Ser Leu Leu Leu Gln Tyr Leu 

            20                  25                  30          





Val Gly Asp Lys Arg Gln Pro Arg Leu Leu Glu Pro Gly Ser Leu Gly 

        35                  40                  45              





Gly Ile Pro Ser Pro Ala Lys Ser Glu Glu Gln Lys Met Ile Glu Lys 

    50                  55                  60                  





Ala Met Glu Ser Cys Ala Phe Lys Ala Ala Leu Ala Cys Val Gly Gly 

65                  70                  75                  80  





Phe Val Leu Gly Gly Ala Phe Gly Val Phe Thr Ala Gly Ile Asp Thr 

                85                  90                  95      





Asn Val Gly Phe Asp Pro Lys Asp Pro Tyr Arg Thr Pro Thr Ala Lys 

            100                 105                 110         





Glu Val Leu Lys Asp Met Gly Gln Arg Gly Met Ser Tyr Ala Lys Asn 

        115                 120                 125             





Phe Ala Ile Val Gly Ala Met Phe Ser Cys Thr Glu Cys Leu Ile Glu 

    130                 135                 140                 





Ser Tyr Arg Gly Thr Ser Asp Trp Lys Asn Ser Val Ile Ser Gly Cys 

145                 150                 155                 160 





Ile Thr Gly Gly Ala Ile Gly Phe Arg Ala Gly Leu Lys Ala Gly Ala 

                165                 170                 175     





Ile Gly Cys Gly Gly Phe Ala Ala Phe Ser Ala Ala Ile Asp Tyr Tyr 

            180                 185                 190         





Leu Arg 

        





<210>  70

<211>  188

<212>  PRT

<213>  Homo sapiens



<400>  70



Met Ala Gly Leu Ser Arg Gln Leu Cys Ala Leu Ser His Pro Lys Lys 

1               5                   10                  15      





Ala Ala Glu Thr Gln Thr Ala Glu Pro Gly Gly Ala His Ala Val Cys 

            20                  25                  30          





Ser Arg His Pro Val Arg Val Lys Gly Leu Glu Gly Ser Glu Met Glu 

        35                  40                  45              





Ser Ala Arg Glu Asn Ile Asp Leu Gln Pro Gly Ser Ser Asp Pro Arg 

    50                  55                  60                  





Ser Gln Pro Ile Asn Leu Asn His Tyr Ala Thr Lys Lys Ser Val Ala 

65                  70                  75                  80  





Glu Ser Met Leu Asp Val Ala Leu Phe Met Ser Asn Ala Met Arg Leu 

                85                  90                  95      





Lys Ala Val Leu Glu Gln Gly Pro Ser Ser His Tyr Tyr Thr Thr Leu 

            100                 105                 110         





Val Thr Leu Ile Ser Leu Ser Leu Leu Leu Gln Val Val Ile Gly Val 

        115                 120                 125             





Leu Leu Val Val Ile Ala Arg Leu Asn Leu Asn Glu Val Glu Lys Gln 

    130                 135                 140                 





Trp Arg Leu Asn Gln Leu Asn Asn Ala Ala Thr Ile Leu Val Phe Phe 

145                 150                 155                 160 





Thr Val Val Ile Asn Val Phe Ile Thr Ala Phe Gly Ala His Lys Thr 

                165                 170                 175     





Gly Phe Leu Ala Ala Arg Ala Ser Arg Asn Pro Leu 

            180                 185             





<210>  71

<211>  117

<212>  PRT

<213>  Homo sapiens



<400>  71



Met Lys His Lys Arg Asp Asp Gly Pro Glu Lys Gln Glu Asp Glu Ala 

1               5                   10                  15      





Val Asp Val Thr Pro Val Met Thr Cys Val Phe Val Val Met Cys Cys 

            20                  25                  30          





Ser Met Leu Val Leu Leu Tyr Tyr Phe Tyr Asp Leu Leu Val Tyr Val 

        35                  40                  45              





Val Ile Gly Ile Phe Cys Leu Ala Ser Ala Thr Gly Leu Tyr Ser Cys 

    50                  55                  60                  





Leu Ala Pro Cys Val Arg Arg Leu Pro Phe Gly Lys Cys Arg Ile Pro 

65                  70                  75                  80  





Asn Asn Ser Leu Pro Tyr Phe His Lys Arg Pro Gln Ala Arg Met Leu 

                85                  90                  95      





Leu Leu Ala Leu Phe Cys Val Ala Val Ser Val Val Trp Gly Val Phe 

            100                 105                 110         





Arg Asn Glu Asp Gln 

        115         





<210>  72

<211>  231

<212>  PRT

<213>  Homo sapiens



<400>  72



Met Asp Pro Glu His Ala Lys Pro Glu Ser Ser Glu Ala Pro Ser Gly 

1               5                   10                  15      





Asn Leu Lys Gln Pro Glu Thr Ala Ala Ala Leu Ala Ser Ser Gly Ser 

            20                  25                  30          





Val Val Ser Ser Val Pro Lys Ala Gln Arg Asn Ile Ser Ala Lys Thr 

        35                  40                  45              





Ala Pro Arg Lys His Pro Ala Val Ser Ile Arg Ser Ala Gln Ser Ala 

    50                  55                  60                  





Ala Ala Ala Arg Pro Gln Gly Ser Glu Gly Thr Ala Pro Ser Arg Lys 

65                  70                  75                  80  





Ala Thr Thr Arg Pro Pro Pro Lys Pro Thr Leu Pro Pro Pro Thr Pro 

                85                  90                  95      





Ser Ala His Thr Glu Ser Lys Leu Leu Asn Glu Met Ala Ile Lys Glu 

            100                 105                 110         





Arg Val Glu Gly Arg Ala Lys Val Pro Tyr Lys Phe Arg Asp Ser Leu 

        115                 120                 125             





Lys Arg Phe Ser Phe Ser Pro Thr Gly Met Leu Lys Ile Leu Arg Leu 

    130                 135                 140                 





Ser Leu Ile Leu Gly Ala Leu Ala Cys Phe Ile Ile Thr Gln Ala Asn 

145                 150                 155                 160 





Glu Ser Phe Ile Thr Ile Thr Ser Leu Glu Ile Cys Ile Val Val Phe 

                165                 170                 175     





Phe Ile Leu Ile Tyr Val Leu Thr Leu His His Leu Leu Thr Tyr Leu 

            180                 185                 190         





His Trp Pro Leu Leu Asp Leu Thr Asn Ser Ile Ile Thr Ala Val Phe 

        195                 200                 205             





Leu Ser Val Val Ala Ile Leu Ala Met Gln Glu Lys Lys Arg Arg His 

    210                 215                 220                 





Leu Leu Tyr Val Gly Gly Arg 

225                 230     





<210>  73

<211>  138

<212>  PRT

<213>  Homo sapiens



<400>  73



Met Ile Ser Leu Thr Asp Thr Gln Lys Ile Gly Met Gly Leu Thr Gly 

1               5                   10                  15      





Phe Gly Val Phe Phe Leu Phe Phe Gly Met Ile Leu Phe Phe Asp Lys 

            20                  25                  30          





Ala Leu Leu Ala Ile Gly Asn Val Leu Phe Val Ala Gly Leu Ala Phe 

        35                  40                  45              





Val Ile Gly Leu Glu Arg Thr Phe Arg Phe Phe Phe Gln Lys His Lys 

    50                  55                  60                  





Met Lys Ala Thr Gly Phe Phe Leu Gly Gly Val Phe Val Val Leu Ile 

65                  70                  75                  80  





Gly Trp Pro Leu Ile Gly Met Ile Phe Glu Ile Tyr Gly Phe Phe Leu 

                85                  90                  95      





Leu Phe Arg Gly Phe Phe Pro Val Val Val Gly Phe Ile Arg Arg Val 

            100                 105                 110         





Pro Val Leu Gly Ser Leu Leu Asn Leu Pro Gly Ile Arg Ser Phe Val 

        115                 120                 125             





Asp Lys Val Gly Glu Ser Asn Asn Met Val 

    130                 135             





<210>  74

<211>  150

<212>  PRT

<213>  Homo sapiens



<400>  74



Met Lys Asp Glu Val Ala Leu Leu Ala Ala Val Thr Leu Leu Gly Val 

1               5                   10                  15      





Leu Leu Gln Ala Tyr Phe Ser Leu Gln Val Ile Ser Ala Arg Arg Ala 

            20                  25                  30          





Phe Arg Val Ser Pro Pro Leu Thr Thr Gly Pro Pro Glu Phe Glu Arg 

        35                  40                  45              





Val Tyr Arg Ala Gln Val Asn Cys Ser Glu Tyr Phe Pro Leu Phe Leu 

    50                  55                  60                  





Ala Thr Leu Trp Val Ala Gly Ile Phe Phe His Glu Gly Ala Ala Ala 

65                  70                  75                  80  





Leu Cys Gly Leu Val Tyr Leu Phe Ala Arg Leu Arg Tyr Phe Gln Gly 

                85                  90                  95      





Tyr Ala Arg Ser Ala Gln Leu Arg Leu Ala Pro Leu Tyr Ala Ser Ala 

            100                 105                 110         





Arg Ala Leu Trp Leu Leu Val Ala Leu Ala Ala Leu Gly Leu Leu Ala 

        115                 120                 125             





His Phe Leu Pro Ala Ala Leu Arg Ala Ala Leu Leu Gly Arg Leu Arg 

    130                 135                 140                 





Thr Leu Leu Pro Trp Ala 

145                 150 





<210>  75

<211>  152

<212>  PRT

<213>  Homo sapiens



<400>  75



Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 

1               5                   10                  15      





Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 

            20                  25                  30          





Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 

        35                  40                  45              





Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Thr 

    50                  55                  60                  





Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 

65                  70                  75                  80  





Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 

                85                  90                  95      





Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 

            100                 105                 110         





Arg Gly Gly Phe Leu Gly Ser Ser Gln Asp Arg Ser Ala Tyr Gln Thr 

        115                 120                 125             





Ile Asp Ser Ala Glu Ala Pro Ala Asp Pro Phe Ala Val Pro Glu Gly 

    130                 135                 140                 





Arg Ser Gln Asp Ala Arg Gly Tyr 

145                 150         





<210>  76

<211>  161

<212>  PRT

<213>  Homo sapiens



<400>  76



Met Asp Gln Glu Thr Val Gly Asn Val Val Leu Leu Ala Ile Val Thr 

1               5                   10                  15      





Leu Ile Ser Val Val Gln Asn Gly Phe Phe Ala His Lys Val Glu His 

            20                  25                  30          





Glu Ser Arg Thr Gln Asn Gly Arg Ser Phe Gln Arg Thr Gly Thr Leu 

        35                  40                  45              





Ala Phe Glu Arg Val Tyr Thr Ala Asn Gln Asn Cys Val Asp Ala Tyr 

    50                  55                  60                  





Pro Thr Phe Leu Ala Val Leu Trp Ser Ala Gly Leu Leu Cys Ser Gln 

65                  70                  75                  80  





Val Pro Ala Ala Phe Ala Gly Leu Met Tyr Leu Phe Val Arg Gln Lys 

                85                  90                  95      





Tyr Phe Val Gly Tyr Leu Gly Glu Arg Thr Gln Ser Thr Pro Gly Tyr 

            100                 105                 110         





Ile Phe Gly Lys Arg Ile Ile Leu Phe Leu Phe Leu Met Ser Val Ala 

        115                 120                 125             





Gly Ile Phe Asn Tyr Tyr Leu Ile Phe Phe Phe Gly Ser Asp Phe Glu 

    130                 135                 140                 





Asn Tyr Ile Lys Thr Ile Ser Thr Thr Ile Ser Pro Leu Leu Leu Ile 

145                 150                 155                 160 





Pro 

    





<210>  77

<211>  382

<212>  PRT

<213>  Homo sapiens



<400>  77



Met Ala Glu Gln Thr Tyr Ser Trp Ala Tyr Ser Leu Val Asp Ser Ser 

1               5                   10                  15      





Gln Val Ser Thr Phe Leu Ile Ser Ile Leu Leu Ile Val Tyr Gly Ser 

            20                  25                  30          





Phe Arg Ser Leu Asn Met Asp Phe Glu Asn Gln Asp Lys Glu Lys Asp 

        35                  40                  45              





Ser Asn Ser Ser Ser Gly Ser Phe Asn Gly Asn Ser Thr Asn Asn Ser 

    50                  55                  60                  





Ile Gln Thr Ile Asp Ser Thr Gln Ala Leu Phe Leu Pro Ile Gly Ala 

65                  70                  75                  80  





Ser Val Ser Leu Leu Val Met Phe Phe Phe Phe Asp Ser Val Gln Val 

                85                  90                  95      





Val Phe Thr Ile Cys Thr Val Leu Ala Thr Ile Ala Phe Ala Phe Leu 

            100                 105                 110         





Leu Leu Pro Met Cys Gln Tyr Leu Thr Arg Pro Cys Ser Pro Gln Asn 

        115                 120                 125             





Lys Ile Ser Phe Gly Cys Cys Gly Arg Phe Thr Ala Ala Glu Leu Leu 

    130                 135                 140                 





Ser Phe Ser Leu Ser Val Met Leu Val Leu Ile Trp Val Leu Thr His 

145                 150                 155                 160 





Trp Leu Leu Met Asp Ala Leu Ala Met Gly Leu Cys Val Ala Met Ile 

                165                 170                 175     





Ala Phe Val Arg Leu Pro Ser Leu Lys Val Ser Cys Leu Leu Leu Ser 

            180                 185                 190         





Gly Leu Leu Ile Tyr Asp Val Phe Trp Val Phe Phe Ser Ala Tyr Ile 

        195                 200                 205             





Phe Asn Ser Asn Val Met Val Lys Val Ala Thr Gln Pro Ala Asp Asn 

    210                 215                 220                 





Pro Leu Asp Val Leu Ser Arg Lys Leu His Leu Gly Pro Asn Val Gly 

225                 230                 235                 240 





Arg Asp Val Pro Arg Leu Ser Leu Pro Gly Lys Leu Val Phe Pro Ser 

                245                 250                 255     





Ser Thr Gly Ser His Phe Ser Met Leu Gly Ile Gly Asp Ile Val Met 

            260                 265                 270         





Pro Gly Leu Leu Leu Cys Phe Val Leu Arg Tyr Asp Asn Tyr Lys Lys 

        275                 280                 285             





Gln Ala Ser Gly Asp Ser Cys Gly Ala Pro Gly Pro Ala Asn Ile Ser 

    290                 295                 300                 





Gly Arg Met Gln Lys Val Ser Tyr Phe His Cys Thr Leu Ile Gly Tyr 

305                 310                 315                 320 





Phe Val Gly Leu Leu Thr Ala Thr Val Ala Ser Arg Ile His Arg Ala 

                325                 330                 335     





Ala Gln Pro Ala Leu Leu Tyr Leu Val Pro Phe Thr Leu Leu Pro Leu 

            340                 345                 350         





Leu Thr Met Ala Tyr Leu Lys Gly Asp Leu Arg Arg Met Trp Ser Glu 

        355                 360                 365             





Pro Phe His Ser Lys Ser Ser Ser Ser Arg Phe Leu Glu Val 

    370                 375                 380         





<210>  78

<211>  131

<212>  PRT

<213>  Homo sapiens



<400>  78



Met Ala Gly Val Lys Ala Leu Val Ala Leu Ser Phe Ser Gly Ala Ile 

1               5                   10                  15      





Gly Leu Thr Phe Leu Met Leu Gly Cys Ala Leu Glu Asp Tyr Gly Val 

            20                  25                  30          





Tyr Trp Pro Leu Phe Val Leu Ile Phe His Ala Ile Ser Pro Ile Pro 

        35                  40                  45              





His Phe Ile Ala Lys Arg Val Thr Tyr Asp Ser Asp Ala Thr Ser Ser 

    50                  55                  60                  





Ala Cys Arg Glu Leu Ala Tyr Phe Phe Thr Thr Gly Ile Val Val Ser 

65                  70                  75                  80  





Ala Phe Gly Phe Pro Val Ile Leu Ala Arg Val Ala Val Ile Lys Trp 

                85                  90                  95      





Gly Ala Cys Gly Leu Val Leu Ala Gly Asn Ala Val Ile Phe Leu Thr 

            100                 105                 110         





Ile Gln Gly Phe Phe Leu Ile Phe Gly Arg Gly Asp Asp Phe Ser Trp 

        115                 120                 125             





Glu Gln Trp 

    130     





<210>  79

<211>  152

<212>  PRT

<213>  Homo sapiens



<400>  79



Met Ala Val Leu Ser Lys Glu Tyr Gly Phe Val Leu Leu Thr Gly Ala 

1               5                   10                  15      





Ala Ser Phe Ile Met Val Ala His Leu Ala Ile Asn Val Ser Lys Ala 

            20                  25                  30          





Arg Lys Lys Tyr Lys Val Glu Tyr Pro Ile Met Tyr Ser Thr Asp Pro 

        35                  40                  45              





Glu Asn Gly His Ile Phe Asn Cys Ile Gln Arg Ala His Gln Asn Thr 

    50                  55                  60                  





Leu Glu Val Tyr Pro Pro Phe Leu Phe Phe Leu Ala Val Gly Gly Val 

65                  70                  75                  80  





Tyr His Pro Arg Ile Ala Ser Gly Leu Gly Leu Ala Trp Ile Val Gly 

                85                  90                  95      





Arg Val Leu Tyr Ala Tyr Gly Tyr Tyr Thr Gly Glu Pro Ser Lys Arg 

            100                 105                 110         





Ser Arg Gly Ala Leu Gly Ser Ile Ala Leu Leu Gly Leu Val Gly Thr 

        115                 120                 125             





Thr Val Cys Ser Ala Phe Gln His Leu Gly Trp Val Lys Ser Gly Leu 

    130                 135                 140                 





Gly Ser Gly Pro Lys Cys Cys His 

145                 150         





<210>  80

<211>  351

<212>  PRT

<213>  Homo sapiens



<400>  80



Met Leu Glu Thr Leu Arg Glu Arg Leu Leu Ser Val Gln Gln Asp Phe 

1               5                   10                  15      





Thr Ser Gly Leu Lys Thr Leu Ser Asp Lys Ser Arg Glu Ala Lys Val 

            20                  25                  30          





Lys Ser Lys Pro Arg Thr Val Pro Phe Leu Pro Lys Tyr Ser Ala Gly 

        35                  40                  45              





Leu Glu Leu Leu Ser Arg Tyr Glu Asp Thr Trp Ala Ala Leu His Arg 

    50                  55                  60                  





Arg Ala Lys Asp Cys Ala Ser Ala Gly Glu Leu Val Asp Ser Glu Val 

65                  70                  75                  80  





Val Met Leu Ser Ala His Trp Glu Lys Lys Lys Thr Ser Leu Val Glu 

                85                  90                  95      





Leu Gln Glu Gln Leu Gln Gln Leu Pro Ala Leu Ile Ala Asp Leu Glu 

            100                 105                 110         





Ser Met Thr Ala Asn Leu Thr His Leu Glu Ala Ser Phe Glu Glu Val 

        115                 120                 125             





Glu Asn Asn Leu Leu His Leu Glu Asp Leu Cys Gly Gln Cys Glu Leu 

    130                 135                 140                 





Glu Arg Cys Lys His Met Gln Ser Gln Gln Leu Glu Asn Tyr Lys Lys 

145                 150                 155                 160 





Asn Lys Arg Lys Glu Leu Glu Thr Phe Lys Ala Glu Leu Asp Ala Glu 

                165                 170                 175     





His Ala Gln Lys Val Leu Glu Met Glu His Thr Gln Gln Met Lys Leu 

            180                 185                 190         





Lys Glu Arg Gln Lys Phe Phe Glu Glu Ala Phe Gln Gln Asp Met Glu 

        195                 200                 205             





Gln Tyr Leu Ser Thr Gly Tyr Leu Gln Ile Ala Glu Arg Arg Glu Pro 

    210                 215                 220                 





Ile Gly Ser Met Ser Ser Met Glu Val Asn Val Asp Met Leu Glu Gln 

225                 230                 235                 240 





Met Asp Leu Met Asp Ile Ser Asp Gln Glu Ala Leu Asp Val Phe Leu 

                245                 250                 255     





Asn Ser Gly Gly Glu Glu Asn Thr Val Leu Ser Pro Ala Leu Gly Pro 

            260                 265                 270         





Glu Ser Ser Thr Cys Gln Asn Glu Ile Thr Leu Gln Val Pro Asn Pro 

        275                 280                 285             





Ser Glu Leu Arg Ala Lys Pro Pro Ser Ser Ser Ser Thr Cys Thr Asp 

    290                 295                 300                 





Ser Ala Thr Arg Asp Ile Ser Glu Gly Gly Glu Ser Pro Val Val Gln 

305                 310                 315                 320 





Ser Asp Glu Glu Glu Val Gln Val Asp Thr Ala Leu Ala Thr Ser His 

                325                 330                 335     





Thr Asp Arg Glu Ala Thr Pro Asp Gly Gly Glu Asp Ser Asp Ser 

            340                 345                 350     





<210>  81

<211>  178

<212>  PRT

<213>  Homo sapiens



<400>  81



Met Ser Glu Val Arg Leu Pro Pro Leu Arg Ala Leu Asp Asp Phe Val 

1               5                   10                  15      





Leu Gly Ser Ala Arg Leu Ala Ala Pro Asp Pro Cys Asp Pro Gln Arg 

            20                  25                  30          





Trp Cys His Arg Val Ile Asn Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr 

        35                  40                  45              





Leu Leu Cys Phe Gly Ile Gly Leu Ala Leu Ala Gly Tyr Val Arg Pro 

    50                  55                  60                  





Leu His Thr Leu Leu Ser Ala Leu Val Val Ala Val Ala Leu Gly Val 

65                  70                  75                  80  





Leu Val Trp Ala Ala Glu Thr Arg Ala Ala Val Arg Arg Cys Arg Arg 

                85                  90                  95      





Ser His Pro Ala Ala Cys Leu Ala Ala Val Leu Ala Val Gly Leu Leu 

            100                 105                 110         





Val Leu Trp Val Ala Gly Gly Ala Cys Thr Phe Leu Phe Ser Ile Ala 

        115                 120                 125             





Gly Pro Val Leu Leu Ile Leu Val His Ala Ser Leu Arg Leu Arg Asn 

    130                 135                 140                 





Leu Lys Asn Lys Ile Glu Asn Lys Ile Glu Ser Ile Gly Leu Lys Arg 

145                 150                 155                 160 





Thr Pro Met Gly Leu Leu Leu Glu Ala Leu Gly Gln Glu Gln Glu Ala 

                165                 170                 175     





Gly Ser 

        





<210>  82

<211>  216

<212>  PRT

<213>  Homo sapiens



<400>  82



Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val 

1               5                   10                  15      





Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro 

            20                  25                  30          





Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro 

        35                  40                  45              





Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala 

    50                  55                  60                  





Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys 

65                  70                  75                  80  





Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala 

                85                  90                  95      





Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly 

            100                 105                 110         





Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala 

        115                 120                 125             





His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly 

    130                 135                 140                 





Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe Ala Phe Ala Gly Leu 

145                 150                 155                 160 





Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu His Cys Phe Thr Pro 

                165                 170                 175     





Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala Phe Leu Ser Pro Leu 

            180                 185                 190         





Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr Cys Asp Tyr Lys His 

        195                 200                 205             





His Trp Gln Gly Pro Phe Lys Trp 

    210                 215     





<210>  83

<211>  185

<212>  PRT

<213>  Homo sapiens



<400>  83



Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 

1               5                   10                  15      





Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 

            20                  25                  30          





Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 

        35                  40                  45              





Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 

    50                  55                  60                  





Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 

65                  70                  75                  80  





Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 

                85                  90                  95      





Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 

            100                 105                 110         





Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 

        115                 120                 125             





Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 

    130                 135                 140                 





Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 

145                 150                 155                 160 





Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 

                165                 170                 175     





Pro Ser Gly Ser Ala Pro His Phe Leu 

            180                 185 





<210>  84

<211>  112

<212>  PRT

<213>  Homo sapiens



<400>  84



Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 

1               5                   10                  15      





Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 

            20                  25                  30          





Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 

        35                  40                  45              





Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 

    50                  55                  60                  





Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 

65                  70                  75                  80  





Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 

                85                  90                  95      





Lys Asp Gln Leu Gly Lys Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 

            100                 105                 110         





<210>  85

<211>  140

<212>  PRT

<213>  Homo sapiens



<400>  85



Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 

1               5                   10                  15      





Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 

            20                  25                  30          





Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 

        35                  40                  45              





Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 

    50                  55                  60                  





Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 

65                  70                  75                  80  





Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 

                85                  90                  95      





Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 

            100                 105                 110         





Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 

        115                 120                 125             





Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 

    130                 135                 140 





<210>  86

<211>  134

<212>  PRT

<213>  Homo sapiens



<400>  86



Met Asp Val Phe Met Lys Gly Leu Ser Met Ala Lys Glu Gly Val Val 

1               5                   10                  15      





Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Thr Glu Ala Ala Glu Lys 

            20                  25                  30          





Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Arg Glu Gly Val 

        35                  40                  45              





Val Gln Gly Val Ala Ser Val Ala Glu Lys Thr Lys Glu Gln Ala Ser 

    50                  55                  60                  





His Leu Gly Gly Ala Val Phe Ser Gly Ala Gly Asn Ile Ala Ala Ala 

65                  70                  75                  80  





Thr Gly Leu Val Lys Arg Glu Glu Phe Pro Thr Asp Leu Lys Pro Glu 

                85                  90                  95      





Glu Val Ala Gln Glu Ala Ala Glu Glu Pro Leu Ile Glu Pro Leu Met 

            100                 105                 110         





Glu Pro Glu Gly Glu Ser Tyr Glu Asp Pro Pro Gln Glu Glu Tyr Gln 

        115                 120                 125             





Glu Tyr Glu Pro Glu Ala 

    130                 





<210>  87

<211>  134

<212>  PRT

<213>  Homo sapiens



<400>  87



Met Asp Val Phe Met Lys Gly Leu Ser Met Ala Lys Glu Gly Val Val 

1               5                   10                  15      





Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Thr Glu Ala Ala Glu Lys 

            20                  25                  30          





Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Arg Glu Gly Val 

        35                  40                  45              





Val Gln Gly Val Ala Ser Val Ala Glu Lys Thr Lys Glu Gln Ala Ser 

    50                  55                  60                  





His Leu Gly Gly Ala Val Phe Ser Gly Ala Gly Asn Ile Ala Ala Ala 

65                  70                  75                  80  





Thr Gly Leu Val Lys Arg Glu Glu Phe Pro Thr Asp Leu Lys Pro Glu 

                85                  90                  95      





Glu Val Ala Gln Glu Ala Ala Glu Glu Pro Leu Ile Glu Pro Leu Met 

            100                 105                 110         





Glu Pro Glu Gly Glu Ser Tyr Glu Asp Pro Pro Gln Glu Glu Tyr Gln 

        115                 120                 125             





Glu Tyr Glu Pro Glu Ala 

    130                 





<210>  88

<211>  127

<212>  PRT

<213>  Homo sapiens



<400>  88



Met Asp Val Phe Lys Lys Gly Phe Ser Ile Ala Lys Glu Gly Val Val 

1               5                   10                  15      





Gly Ala Val Glu Lys Thr Lys Gln Gly Val Thr Glu Ala Ala Glu Lys 

            20                  25                  30          





Thr Lys Glu Gly Val Met Tyr Val Gly Ala Lys Thr Lys Glu Asn Val 

        35                  40                  45              





Val Gln Ser Val Thr Ser Val Ala Glu Lys Thr Lys Glu Gln Ala Asn 

    50                  55                  60                  





Ala Val Ser Glu Ala Val Val Ser Ser Val Asn Thr Val Ala Thr Lys 

65                  70                  75                  80  





Thr Val Glu Glu Ala Glu Asn Ile Ala Val Thr Ser Gly Val Val Arg 

                85                  90                  95      





Lys Glu Asp Leu Arg Pro Ser Ala Pro Gln Gln Glu Gly Val Ala Ser 

            100                 105                 110         





Lys Glu Lys Glu Glu Val Ala Glu Glu Ala Gln Ser Gly Gly Asp 

        115                 120                 125         





<210>  89

<211>  262

<212>  PRT

<213>  Danio rerio



<400>  89



Met Lys Phe Val Ala Leu Ala Leu Thr Leu Leu Leu Ala Leu Gly Ser 

1               5                   10                  15      





Gln Ala Asn Leu Phe Gln Ala Asp Ala Pro Thr Gln Leu Glu His Tyr 

            20                  25                  30          





Lys Ala Ala Ala Leu Val Tyr Leu Asn Gln Val Lys Asp Gln Ala Glu 

        35                  40                  45              





Lys Ala Leu Asp Asn Leu Asp Gly Thr Asp Tyr Glu Gln Tyr Lys Leu 

    50                  55                  60                  





Gln Leu Ser Glu Ser Leu Thr Lys Leu Gln Glu Tyr Ala Gln Thr Thr 

65                  70                  75                  80  





Ser Gln Ala Leu Thr Pro Tyr Ala Glu Thr Ile Ser Thr Gln Leu Met 

                85                  90                  95      





Glu Asn Thr Lys Gln Leu Arg Glu Arg Val Met Thr Asp Val Glu Asp 

            100                 105                 110         





Leu Arg Ser Lys Leu Glu Pro His Arg Ala Glu Leu Tyr Thr Ala Leu 

        115                 120                 125             





Gln Lys His Ile Asp Glu Tyr Arg Glu Lys Leu Glu Pro Val Phe Gln 

    130                 135                 140                 





Glu Tyr Ser Ala Leu Asn Arg Gln Asn Ala Glu Gln Leu Arg Ala Lys 

145                 150                 155                 160 





Leu Glu Pro Leu Met Asp Asp Ile Arg Lys Ala Phe Glu Ser Asn Ile 

                165                 170                 175     





Glu Glu Thr Lys Ser Lys Val Val Pro Met Val Glu Ala Val Arg Thr 

            180                 185                 190         





Lys Leu Thr Glu Arg Leu Glu Asp Leu Arg Thr Met Ala Ala Pro Tyr 

        195                 200                 205             





Ala Glu Glu Tyr Lys Glu Gln Leu Val Lys Ala Val Glu Glu Ala Arg 

    210                 215                 220                 





Glu Lys Ile Ala Pro His Thr Gln Asp Leu Gln Thr Arg Met Glu Pro 

225                 230                 235                 240 





Tyr Met Glu Asn Val Arg Thr Thr Phe Ala Gln Met Tyr Glu Thr Ile 

                245                 250                 255     





Ala Lys Ala Ile Gln Ala 

            260         







