                         SEQUENCE LISTING

<110>  Navigen
 
<120>  Compositions and methods for diagnosing and treating diabetic 
       micro vascular complications

<130>  38263/7

<150>  US 60/894397
<151>  2007-03-12

<160>  101   

<170>  PatentIn version 3.4

<210>  1
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  1
gctgggattt acagctaagg ttttatggct tctggaaacc ctgagccaga tgagtgagat     60

tcccagagca ggagaccaag actagctggt ctctcacacc                          100


<210>  2
<211>  100
<212>  DNA
<213>  homo sapiens

<400>  2
gctgggattt acagctaagg ttttatggct tctggaaacc ctgagccaga ggagtgagat     60

tcccagagca ggagaccaag actagctggt ctctcacacc                          100


<210>  3
<211>  193
<212>  PRT
<213>  homo sapiens

<400>  3

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Gln Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  4
<211>  3398
<212>  DNA
<213>  homo sapiens

<400>  4
agcttctggg cttccagacc cagctacttt gcggaactca gcaacccagg catctctgag     60

tctccgccca agaccgggat gccccccagg aggtgtccgg gagcccagcc tttcccagat    120

agcagctccg ccagtcccaa gggtgcgcaa ccggctgcac tcccctcccg cgacccaggg    180

cccgggagca gcccccatga cccacacgca cgtctgcagc agccccgtca gccccggagc    240

ctcaacccag gcgtcctgcc cctgctctga ccccgggtgg cccctacccc tggcgacccc    300

tcacgcacac agcctctccc ccacccccac ccgcgcacgc acacatgcag ataacagccc    360

cgacccccgg ccagagccgc agagtccctg ggccaccccg gccgctcgct gcgctgcgcc    420

gcaccgcgct gtcctcccgg agccggaccg gggccaccgc gcccgctctg ctccgacacc    480

gcgccccctg gacagccgcc ctctcctcca ggcccgtggg gctggccctg caccgccgag    540

cttcccggga tgagggcccc cggtgtggtc acccggcgcc ccaggtcgct gagggacccc    600

ggccaggcgc ggagatgggg gtgcacggtg agtactcgcg ggctgggcgc tcccgcccgc    660

ccgggtccct gtttgagcgg ggatttagcg ccccggctat tggccaggag gtggctgggt    720

tcaaggaccg gcgacttgtc aaggaccccg gaagggggag gggggtgggg cagcctccac    780

gtgccagcgg ggacttgggg gagtccttgg ggatggcaaa aacctgacct gtgaagggga    840

cacagtttgg gggttgaggg gaagaaggtt tggggggttc tgctgtgcca gtggagagga    900

agctgataag ctgataacct gggcgctgga gccaccactt atctgccaga ggggaagcct    960

ctgtcacacc aggattgaag tttggccgga gaagtggatg ctggtagcct gggggtgggg   1020

tgtgcacacg gcagcaggat tgaatgaagg ccagggaggc agcacctgag tgcttgcatg   1080

gttggggaca ggaaggacga gctggggcag agacgtgggg atgaaggaag ctgtccttcc   1140

acagccaccc ttctccctcc ccgcctgact ctcagcctgg ctatctgttc tagaatgtcc   1200

tgcctggctg tggcttctcc tgtccctgct gtcgctccct ctgggcctcc cagtcctggg   1260

cgccccacca cgcctcatct gtgacagccg agtcctgcag aggtacctct tggaggccaa   1320

ggaggccgag aatatcacgg tgagacccct tccccagcac attccacaga actcacgctc   1380

agggcttcag ggaactcctc ccagatccag gaacctggca cttggtttgg ggtggagttg   1440

ggaagctaga cactgccccc ctacataaga ataagtctgg tggccccaaa ccatacctgg   1500

aaactaggca aggagcaaag ccagcagatc ctacgcctgt ggccagggcc agagccttca   1560

gggacccttg actccccggg ctgtgtgcat ttcagacggg ctgtgctgaa cactgcagct   1620

tgaatgagaa tatcactgtc ccagacacca aagttaattt ctatgcctgg aagaggatgg   1680

aggtgagttc cttttttttt ttttttcctt tcttttggag aatctcattt gcgagcctga   1740

ttttggatga aagggagaat gatcgaggga aaggtaaaat ggagcagcag agatgaggct   1800

gcctgggcgc agaggctcac gtctataatc ccaggctgag atggccgaga tgggagaatt   1860

gcttgagccc tggagtttca gaccaaccta ggcagcatag tgagatcccc catctctaca   1920

aacatttaaa aaaattagtc aggtgaagtg gtgcatggtg gtagtcccag atatttggaa   1980

ggctgaggcg ggaggatcgc ttgagcccag gaatttgagg ctgcagtgag ctgtgatcac   2040

accactgcac tccagcctca gtgacagagt gaggccctgt ctcaaaaaag aaaagaaaaa   2100

agaaaaataa tgagggctgt atggaatacg ttcattattc attcactcac tcactcactc   2160

attcattcat tcattcattc aacaagtctt attgcatacc ttctgtttgc tcagcttggt   2220

gcttggggct gctgaggggc aggagggaga gggtgacatc cctcagctga ctcccagagt   2280

ccactccctg taggtcgggc agcaggccgt agaagtctgg cagggcctgg ccctgctgtc   2340

ggaagctgtc ctgcggggcc aggccctgtt ggtcaactct tcccagccgt gggagcccct   2400

gcagctgcat gtggataaag ccgtcagtgg ccttcgcagc ctcaccactc tgcttcgggc   2460

tctgggagcc caggtgagta ggagcggaca cttctgcttg ccctttctgt aagaagggga   2520

gaagggtctt gctaaggagt agaggaactg tccgtattcc ttccctttct gtggcactgc   2580

agcgacctcc tgttttctcc ttggcagaag gaagccatct cccctccaga tgcggcctca   2640

gctgctccac tccgaacaat cactgctgac actttccgca aactcttccg agtctactcc   2700

aatttcctcc ggggaaagct gaagctgtac acaggggagg cctgcaggac aggggacaga   2760

tgaccaggtg tgtccacctg ggcatatcca ccacctccct caccaacatt gcttgtgcca   2820

caccctcccc cgccactcct gaaccccgtc gaggggctct cagctcagcg ccagcctgtc   2880

ccatggacac tccagtgcca ccaatgacat ctcaggggcc agaggaactg tccagagagc   2940

aactctgaga tctaaggatg tcacagggcc aacttgaggg cccagagcag gaagcattca   3000

gagagcagct ttaaactcag ggacagaccc atgctgggaa gacgcctgag ctcactcggc   3060

accctgcaaa attgatgcca ggacacgctt tggaggcgat ttacctgttt tcgcacctac   3120

catcagggac aggatgacct ggagaactta ggtggcaagc tgtgacttct ccaggtctca   3180

cgggcatggg cactcccttg gtggcaagag cccccttgac accggggtgg tgggaaccat   3240

gaagacagga tgggggctgg cctctggctc tcatggggtc caacttttgt gtattcttca   3300

acctcattga caagaactga aaccaccaat atgactcttg gcttttctgt tttctgggaa   3360

cctccaaatc ccctggctct gtcccactcc tggcagca                           3398


<210>  5
<211>  20
<212>  DNA
<213>  primer

<400>  5
ccaccctgct gcttttactc                                                 20


<210>  6
<211>  20
<212>  DNA
<213>  primer

<400>  6
ctcagtctgg gaccttctgc                                                 20


<210>  7
<211>  20
<212>  DNA
<213>  primer

<400>  7
gtgaaggtcg gtgtgaacgg                                                 20


<210>  8
<211>  20
<212>  DNA
<213>  primer

<400>  8
gccgttgaat ttgccgtgag                                                 20


<210>  9
<211>  29
<212>  DNA
<213>  primer

<400>  9
cggggtacca actcctgggc tcaaaggat                                       29


<210>  10
<211>  34
<212>  DNA
<213>  primer

<400>  10
ccgctcgagt ccgcgcctgg ccggggtccc tcag                                 34


<210>  11
<211>  34
<212>  DNA
<213>  primer

<400>  11
cggggtaccc ctgcacaatg gactgtgtgc tctg                                 34


<210>  12
<211>  34
<212>  DNA
<213>  primer

<400>  12
ccgctcgagt ccgcgcctgg ccggggtccc tcag                                 34


<210>  13
<211>  20
<212>  DNA
<213>  primer

<400>  13
aagttggaag gaccacatgc                                                 20


<210>  14
<211>  20
<212>  DNA
<213>  primer

<400>  14
tagctgagcg agcacacact                                                 20


<210>  15
<211>  40
<212>  DNA
<213>  primer

<400>  15
ggattacttt gcagtcccag caacatggtg ggctggactc                           40


<210>  16
<211>  20
<212>  DNA
<213>  primer

<400>  16
gatgagcagg atgcatgaga                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  primer

<400>  17
cttgatgtct gtgggggact                                                 20


<210>  18
<211>  28
<212>  DNA
<213>  primer

<400>  18
gtaaatagtt gctatactgt attgtttt                                        28


<210>  19
<211>  20
<212>  DNA
<213>  primer

<400>  19
gtccattgtg caggacacac                                                 20


<210>  20
<211>  20
<212>  DNA
<213>  primer

<400>  20
aactcctggg ctcaaaggat                                                 20


<210>  21
<211>  28
<212>  DNA
<213>  primer

<400>  21
ttatggcttc tggaaaccct gagccaga                                        28


<210>  22
<211>  20
<212>  DNA
<213>  primer

<400>  22
gactcagtgg cttggaggag                                                 20


<210>  23
<211>  20
<212>  DNA
<213>  primer

<400>  23
gccagatttg gaagcatcat                                                 20


<210>  24
<211>  34
<212>  DNA
<213>  primer

<400>  24
ttaaccactt cctagctctg ttcacatcaa atcg                                 34


<210>  25
<211>  20
<212>  DNA
<213>  primer

<400>  25
ggctgtgcaa tttaccacct                                                 20


<210>  26
<211>  19
<212>  DNA
<213>  primer

<400>  26
gtcacctgtt ccctgctgt                                                  19


<210>  27
<211>  46
<212>  DNA
<213>  primer

<400>  27
gacacaggct acttgttccg aagttttaag ctgtagatgt tcccaa                    46


<210>  28
<211>  20
<212>  DNA
<213>  primer

<400>  28
aggagaatgc tgcctctgaa                                                 20


<210>  29
<211>  20
<212>  DNA
<213>  primer

<400>  29
tctcgatctc ctgacctcgt                                                 20


<210>  30
<211>  34
<212>  DNA
<213>  primer

<400>  30
aatatctatc tagtggaaac acaaaatgct tata                                 34


<210>  31
<211>  20
<212>  DNA
<213>  primer 

<400>  31
aacctcccca cagaaaggat                                                 20


<210>  32
<211>  20
<212>  DNA
<213>  primer

<400>  32
cccctggatt gtcactcatt                                                 20


<210>  33
<211>  52
<212>  DNA
<213>  primer

<400>  33
atttcttctg aatgaagacc tttggatttc taaaagcacc aaaacaaggc tt             52


<210>  34
<211>  20
<212>  DNA
<213>  primer

<400>  34
tcctgaatcc agaccctcac                                                 20


<210>  35
<211>  20
<212>  DNA
<213>  primer

<400>  35
gtccctctgg gagtttcctc                                                 20


<210>  36
<211>  40
<212>  DNA
<213>  primer

<400>  36
ttttgattct ttccaggctc atgaacttga aagcatttac                           40


<210>  37
<211>  20
<212>  DNA
<213>  primer

<400>  37
gccaccgaag agtggaaata                                                 20


<210>  38
<211>  20
<212>  DNA
<213>  primer

<400>  38
ctacttggga ggctgaggtg                                                 20


<210>  39
<211>  28
<212>  DNA
<213>  primer

<400>  39
aaattgatga aaatggtaaa ctgtggcc                                        28


<210>  40
<211>  20
<212>  DNA
<213>  primer

<400>  40
gcggatgaaa aggaaactga                                                 20


<210>  41
<211>  20
<212>  DNA
<213>  primer

<400>  41
ttttggtcta ccctgccaag                                                 20


<210>  42
<211>  20
<212>  DNA
<213>  primer

<400>  42
atgcagcagc ctctaagtca                                                 20


<210>  43
<211>  20
<212>  DNA
<213>  primer

<400>  43
ccctccccca tgaaaactat                                                 20


<210>  44
<211>  20
<212>  DNA
<213>  primer

<400>  44
ttcacagaag tgagcggttg                                                 20


<210>  45
<211>  40
<212>  DNA
<213>  primer

<400>  45
gtatgatttc tcctgccaat atcataagct gagaatattt                           40


<210>  46
<211>  20
<212>  DNA
<213>  primer

<400>  46
aggcagaagt ttccctggtt                                                 20


<210>  47
<211>  20
<212>  DNA
<213>  primer

<400>  47
aatccatgtg ggagagttgc                                                 20


<210>  48
<211>  28
<212>  DNA
<213>  primer

<400>  48
ttagcttctt tcttcctcaa ggactttc                                        28


<210>  49
<211>  21
<212>  DNA
<213>  primer

<400>  49
ccactacggc ctcaatgaga g                                               21


<210>  50
<211>  20
<212>  DNA
<213>  primer

<400>  50
tgccaagtat tgcatcgaga                                                 20


<210>  51
<211>  33
<212>  DNA
<213>  primer

<400>  51
taaatagaga attacttccc taggaccacc aga                                  33


<210>  52
<211>  20
<212>  DNA
<213>  primer

<400>  52
gtagaagggc acaagcaagc                                                 20


<210>  53
<211>  19
<212>  DNA
<213>  primer

<400>  53
aggaaacctg ctttgctga                                                  19


<210>  54
<211>  41
<212>  DNA
<213>  primer

<400>  54
acatagcaat tcatcaaaca acagcgtgct tccaagtcac c                         41


<210>  55
<211>  20
<212>  DNA
<213>  primer

<400>  55
ctgagcgcta aaccagaacc                                                 20


<210>  56
<211>  21
<212>  DNA
<213>  primer

<400>  56
gcaccactgc acttccagtt a                                               21


<210>  57
<211>  34
<212>  DNA
<213>  primer

<400>  57
ctcaaagacg ggatgcttgt cgtcgagtct cata                                 34


<210>  58
<211>  20
<212>  DNA
<213>  primer

<400>  58
tagattctgg aattcctgtg                                                 20


<210>  59
<211>  20
<212>  DNA
<213>  primer

<400>  59
ggtaatttcc aagatacaac                                                 20


<210>  60
<211>  52
<212>  DNA
<213>  primer

<400>  60
ataggcttga gtgggagctt ttgttctgtg tcttaaaatt attgatattg tc             52


<210>  61
<211>  20
<212>  DNA
<213>  primer

<400>  61
gcctggattc tggtgttgat                                                 20


<210>  62
<211>  20
<212>  DNA
<213>  primer

<400>  62
acgctgggtg tagggactta                                                 20


<210>  63
<211>  57
<212>  DNA
<213>  primer

<400>  63
tcgttgtatg aattttagca ttacagatac cacacctatt agatatgggc aggacta        57


<210>  64
<211>  20
<212>  DNA
<213>  primer

<400>  64
tactcagcaa accccaaagg                                                 20


<210>  65
<211>  20
<212>  DNA
<213>  primer

<400>  65
caatcctctt ctccccaaca                                                 20


<210>  66
<211>  45
<212>  DNA
<213>  primer

<400>  66
cagagaggga gaggcgggag atgtcagaga cggagacgag gcaac                     45


<210>  67
<211>  20
<212>  DNA
<213>  primer

<400>  67
tcctgccaac tcacctctct                                                 20


<210>  68
<211>  20
<212>  DNA
<213>  primer

<400>  68
agggagaccc agatggagat                                                 20


<210>  69
<211>  46
<212>  DNA
<213>  primer

<400>  69
cgcacgcagc agttcttctc cgtggagctg caggcaggag agacgc                    46


<210>  70
<211>  20
<212>  DNA
<213>  primer

<400>  70
acccaaatga tcctccttcc                                                 20


<210>  71
<211>  20
<212>  DNA
<213>  primer

<400>  71
acaccaggca ctcaaattcc                                                 20


<210>  72
<211>  34
<212>  DNA
<213>  primer

<400>  72
ctttggaagt tactccagaa tgtatacctt actt                                 34


<210>  73
<211>  20
<212>  DNA
<213>  primer

<400>  73
acctggcttt ctggatgcta                                                 20


<210>  74
<211>  20
<212>  DNA
<213>  primer

<400>  74
tcatcttgag ggatccaagg                                                 20


<210>  75
<211>  40
<212>  DNA
<213>  primer

<400>  75
gatgtgagcc actgtgcccg acccatatcc tgttccaata                           40


<210>  76
<211>  19
<212>  DNA
<213>  primer

<400>  76
gctgacctca gagcattcc                                                  19


<210>  77
<211>  20
<212>  DNA
<213>  primer

<400>  77
tcacataatt gttgggagcg                                                 20


<210>  78
<211>  53
<212>  DNA
<213>  primer

<400>  78
ccctgcaact gctacaatta acaggatatg ggagagagga ggcacatcat gtg            53


<210>  79
<211>  20
<212>  DNA
<213>  primer

<400>  79
taatccagga tgagccaagg                                                 20


<210>  80
<211>  20
<212>  DNA
<213>  primer

<400>  80
ctcccaaagt gctgggatta                                                 20


<210>  81
<211>  34
<212>  DNA
<213>  primer

<400>  81
gagggtctca gttctgaggc aataggaagc cgtg                                 34


<210>  82
<211>  20
<212>  DNA
<213>  primer

<400>  82
cctgttttcg cacctaccat                                                 20


<210>  83
<211>  20
<212>  DNA
<213>  primer

<400>  83
tagcgaggat gtgcattgag                                                 20


<210>  84
<211>  46
<212>  DNA
<213>  primer

<400>  84
gggcagggtt ggcagctgcc ttactgcggt gaggccttga atggag                    46


<210>  85
<211>  20
<212>  DNA
<213>  primer

<400>  85
tcccaaagtg ctgggattac                                                 20


<210>  86
<211>  20
<212>  DNA
<213>  primer

<400>  86
gtcaggctgg tctcgaactc                                                 20


<210>  87
<211>  28
<212>  DNA
<213>  primer

<400>  87
agacactgga atctaagctg aaggctaa                                        28


<210>  88
<211>  20
<212>  DNA
<213>  primer

<400>  88
gggtgtcaga gcaagactcc                                                 20


<210>  89
<211>  20
<212>  DNA
<213>  primer

<400>  89
agtggggaca cacagaggac                                                 20


<210>  90
<211>  46
<212>  DNA
<213>  primer

<400>  90
gttgttgttg tagttcccta gaggagggag tcattaaaac aggcaa                    46


<210>  91
<211>  20
<212>  DNA
<213>  primer

<400>  91
gcctttctgt gtagggtgga                                                 20


<210>  92
<211>  20
<212>  DNA
<213>  primer

<400>  92
gctgggcatc attagttcgt                                                 20


<210>  93
<211>  46
<212>  DNA
<213>  primer

<400>  93
gttgttgttg tagttcccta gaggagggag tcattaaaac aggcaa                    46


<210>  94
<211>  20
<212>  DNA
<213>  primer

<400>  94
aggagttcaa ggctgcagaa                                                 20


<210>  95
<211>  20
<212>  DNA
<213>  primer

<400>  95
tctctccttc ccaggactca                                                 20


<210>  96
<211>  58
<212>  DNA
<213>  primer

<400>  96
ctctctggtc acggccagta gtacgaccac cacaggcacc agcagtccca gtaggacg       58


<210>  97
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  97
ctgagccaga ggagtgagat t                                               21


<210>  98
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  98
tgagccagat gagtgag                                                    17


<210>  99
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  99
gatgagtgag                                                            10


<210>  100
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Ile Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Ile Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gly Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Ile Asp Ala Pro Val Gly Ile Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Ile Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val 
225                 230                 235                 240 


Ser Leu Leu Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Ile Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Ile Leu 
            260                 265                 270         


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gly Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Ile Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
                405                 410                 415     


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gly Leu Leu Arg Pro Trp Thr Ile Cys Pro Glu Ile Pro Pro Thr 
        435                 440                 445             


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
465                 470                 475                 480 


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys 
            500                 505         


<210>  101
<211>  8647
<212>  DNA
<213>  Homo sapiens

<400>  101
ggatccaccc acctcggcct cccaaagtgc tgggattaca ggcatgagca ctgtgcatgg     60

actatttatt tatttttttg aaacagagtt tcaatcttgt tgcacagcct ggagtgcaat    120

ggtgtgatct cagctcactg caacctctgc cttctggttt caagcaattc tcctgcctca    180

gcctcctgag tagctgggat tacaggcacc caccaccacg ctcgaatata tatatatatt    240

ttttgagacg gagtccgctc tgtcaccagg ctggagtgca gtggccaaat atcggctcac    300

tgaaacctcc ggctcctggg ttcaagcgat tctcctgcag cctcccaagt agctgggatt    360

acaggcatgc agcaccacgc ccatctaatt tttgtatttt tggtagagat ggggttttac    420

catgttggcc aggatggtct tgatctcttg acctcgtgat ctgcccacct cggcctccca    480

aagtgctggg attacaggcg tgacgaccgc gcccggccta cgcctggcta atttttgtat    540

ttttagtaga gacgtggttt cgccatgttg cccaggctgg tctcgaactc ctgacctcat    600

gatccgcctg tctcggcctc ccaaagtgtt gggattacaa gtatgagcca ccgcgccact    660

agccaatttt ttttattttt tgagatgcag tctcactctg ttgcccaggc tggagttgca    720

gtggcatgat cttggctcac tgcaatcttc atctcccaga ctgaagcagt tctcatgcct    780

cagcctcctg agtagctggg attacagcac acgccaccac acctggctaa tttttgtatt    840

tttagtagag atgggatttc accatgttgg ccaggctggt ctcaaactcc tgacctcaag    900

tgatttgccc acgtcggcct cccaaagtgc tgggattata ggcgtgagcc accgcccagc    960

ccaagagaat aaaaatgtgg gtggtaaaaa tttttttccc aaaaattcgt aaatgaaaat   1020

ctcacatatt atgcatactg cccaggagca tggcctagca ctgtgcaaac actcaactgc   1080

tggtcgttgc aaggattatt attggccggc ttcagtggct tgctggtatt cccagcacat   1140

tgggagatgg aggctggagg attgcttaag tccgggattt caagaccagc ctggacaaca   1200

tagtgggatc ccatctctac aaagaatttt aaaaattagc caggtgcagt gggaagattg   1260

cttcagtcca gaggctgcag tgagctatga ttgtgccact gcactccagc ctgggtgaca   1320

gagcaacacc ctgagacaga gagagagagg gggaaggagg gaaggaagga aggaaggaag   1380

gaaggaagga aggaaggaag gaaggaagga aggaaggaaa ggagagagag agagagagag   1440

agagagagag agagagaaaa taatttttat ttatttccag gctgggaaga gatgctgatt   1500

tctgcgataa aatcagtagg tacatttttt ggaatgttcg ctatgtgcca ggctagattt   1560

tacagatgag aagtctgaag ctcaggtaag gtaagtcacc tgtccagggc cacaaagaaa   1620

aaaaaaacgt gtgtctgaag ccagaacggg agctgttgcg cccaactccc tcccctgccc   1680

ccaagcggcc tctgggctcg ggaagggccc ctgcctcctc ccgccaggca cttatctcta   1740

cccaggctga gtgctggccc cgcccctcgg ggatctgcca cttagaggcg cctggtcggg   1800

aagggcctgg tcagctgcgt ccggcggagg cagctgctga cccagctgtg gactgtgccg   1860

ggggtggggg acgcaggggc aggagccctg ggctccccgt ggcgggggct gtatcatgga   1920

ccacctcggg gcgtccctct ggccccaggt cggctccctt tgtctcctgc tcgctggggc   1980

cgcctgggcg cccccgccta acctcccgga ccccaagttc gagagcaaag gtaaggatga   2040

gctgcgtgtg gacccctacg ctggagcctg caggaccatg ctggggcctg aactcccagc   2100

ctaggtcctg ggggccatgc tgtttctgga cttcctgacc gggtcctggg ggccaagctg   2160

gcatctgaac ccttagactg ggtcctggat gggtgggggg cggggtgggg tatgttagga   2220

tccaagactc ctgatcccgt cccgggcaag agctagagtg ggcttaacat tcccgtttta   2280

ccttttcagg gagtctggga catgctaaat cctaaggggg ctgacttggt gctaaggtcc   2340

ctggggggtg gggaccaagc cgatccctag gggagggagg gtaaagcccg ggtccgagtt   2400

agagggccaa gccacaggct actgtaaaca cggtttgtgt gagggcgcca gatcacttgc   2460

ccggcccggt ggagggaggg aggcgggggg cacggttgcc gctatcggtt ggcggggagc   2520

ctgccggggc cgataggggg cccgcctctc cgcacacacc cccagccgcg cgcgtgtcct   2580

aggctggggc ggggctggca gtcccgagct cgaggtcttg aacgccgcgc ccagctcagc   2640

tggccgctgg gtgggcaggt gtgcgccagt ggtgcacggc gggggacagt aaggcgagaa   2700

acttgcccct gggaattagg ggggcaccac ctctgcggac ccctccaagg gacccgcttg   2760

ggaagatggc agggcggggc ttttttctta tcgggtccgc ccaggctgcg ggagggaaga   2820

ggagggggct gtctcccgag gatagagctc agacccccat gcccttcctt tgtcgcccct   2880

ccccagcggc cttgctggcg gcccgggggc ccgaagagct tctgtgcttc accgagcggt   2940

tggaggactt ggtgtgtttc tgggaggaag cggcgagcgc tggggtgggc ccgggcaact   3000

acagcttctc ctaccagctc gagtgagtcc gatccggcgg gtgcctccaa gggcggaggg   3060

agggggtggg gcagagctcc ctggaggtcg tagcctcgta tgtcccctgc tgtttgaggc   3120

ccgacggcgc ctccagtcgt ggtcactgga gggaaacctg cgggtccagg gctggcacgc   3180

ctctatgggc cggggcgcga acactcccgc gatcaccgct ggaacgcgac cccaaacatc   3240

aggctgggat aacaacgcct ccaaatcgag ggtaaggcgt tactacgtcg gggctgggac   3300

gccttctcga ggtagtatcc aaaaggaggc cagcagtgct catgcctgta atcccaactc   3360

tttggaaggt ccagcggaag aaccgcttga gcccaggtgt tcaagaccag cctgggcaac   3420

acagcgagat ccccgtctct taaaaaaaaa ttagactggg cgcggctgca cgcctgtaat   3480

cccagcactt tgggaggctg aggcgggcgg atcacctgag gtcgggagtt tgagagccag   3540

cctggccaac atggagaaac tctatctcta ctaaaaatac aaaattagcc gggcgtggtg   3600

gcgcatgcct gtgatcccag ctactcggga ggctgaggca ggagaatcgc ttgaacccgg   3660

gaggcggagg ttgcggtgag ccgaggtagc gccattgcac tccagcctgg gcaacaagag   3720

cgaaactccg tctcaaaaaa aaaaaaaata aaagccaggc gtggcgcgtg cctgtggtct   3780

caactacttg ggaagctgag gtgggaggat cccttaagcc ccagaatttg aggctccagt   3840

gagccataat cgcgccactg cactccagcc tgggcgacga aggaacacct tgtcacacac   3900

acacacaagg ctagaccttg tgtcacacat acacactgcc ccccacaggc cgggcaatgc   3960

caactccccg gtcccccctc ccaacctgct cccttccctg ggcgcatagg gatgagccat   4020

ggaagctgtg tcgcctgcac caggctccca cggctcgtgg tgcggtgcgc ttctggtgtt   4080

cgctgcctac agccgacacg tcgagcttcg tgcccctaga gttgcgcgtc acagcagcct   4140

ccggcgctcc gcgatatcac cgtgtcatcc acatcaatga agtaggtaag tgctctggga   4200

atggaggagt ggtcggagga gagggtctca gtcctcgccc acctgaccaa cccccatgcc   4260

tgcagtgctc ctagacgccc ccgtggggct ggtggcccgg ttggctgacg agagcggcca   4320

cgtagtgttg cgctggctcc cgccgcctga gacacccatg acgtctcaca tccgctacga   4380

ggtggacgtc tcggccggca acggcgcagg gagcgtacag agggtgaggc cactccctac   4440

ggcccagccc ccaaagctcc actgactacg gcccagccac gcctctcgag gtcgcgcccg   4500

gtgccgcttt cagggccggt ccgtaacatc ccacatccca ttaccctggt gctgaagacc   4560

gttccacgcc cacagacaca gccccctttc ctaatgtcct cgcaagcctg ttgaacccca   4620

acttcttctc cctccgtccc gtaaccctag acccctttag cgcccgggtc cctctacgag   4680

tgctagccca gatattaaat tgcccgggtc ccgccctttc gtaccagaga ctctctctct   4740

gattggccct gagctttctt gggctcctcc ccctactctt attggtccca ttgcaattct   4800

agggcaccgt tttcctttcc cctgattggc tcagttccac cagggcccgc ccccacgtca   4860

tctatttttg tctgctacgc gtccctcgcc ctgattccgc ccccaggtgg agatcctgga   4920

gggccgcacc gagtgtgtgc tgagcaacct gcggggccgg acgcgctaca ccttcgccgt   4980

ccgcgcgcgt atggctgagc cgagcttcgg cggcttctgg agcgcctggt cggagcctgt   5040

gtcgctgctg acgcctagcg gtgaggcccc aggcgggggt gtaggaggag ccagggcgaa   5100

tcacggggca agcccaccgc cctgacctcc tccccgcctc ttagacctgg accccctcat   5160

cctgacgctc tccctcatcc tcgtggtcat cctggtgctg ctgaccgtgc tcgcgctgct   5220

ctcccaccgc cggtgagctc cccatttggg cgctgggccc agactcctcc ccgccaacgg   5280

tcctctttca ctatggaaac ctaggctcag agagagacac gcacttgccc aaggtcacgc   5340

agtaaggatt cacatcagtg gcagggctgg gatgcatgcc agactagacc cagactcttc   5400

gttaacattt tctgctcttg gggactttca cctgattttc cttctacatc aggggctgcc   5460

atttcttggg tccctttgtt acttcctttc cccagtgtca tcacctttgt aaaatcaact   5520

agatggattt agtgaaagaa tttaagaccc tgaatgcctc cgcacccctg cggtcaagct   5580

tctcagacac tatgatcaga ctagccgttc tgaggtattt gtaattccaa gcacacacta   5640

ggtggtttca cacccccaag cttttgccca tgctgttccc tctgcctgga atgcccttcc   5700

tgccttgtct gctaagcaat cttctagtcg tctttcatgg ccctgttcat ttacttggtt   5760

ggaaaataca aacagagtgc caaacatgtg ccaggcactg gagagagaat ggagaacaag   5820

ctagaccctg accacaagtc cctgaccttg tggatctcaa gtcaacaaac aagggaccca   5880

agaaatattt gatgacaaat tgtaatgagt gatatcacag aaacaaacag aatgtggtga   5940

catgacagga tggtcaggga aggctccagg aggaggtgac atcagagtgg aaacctgaag   6000

attggaagga agcagccgct tgaaaagtgg ggagaagaaa cagcaagtgc aaaggccctg   6060

aggtgggaat gagattggaa cgttcagcca gcttcaagaa ttgccacatg catggcctgg   6120

catggtggct cacgcctgta atcccagcac tttgggatgc cgaggcaggc acatcacctg   6180

aggttgggag ttcgcgacca gcctgaccaa catggagaaa ccccacctct actaaaaata   6240

caaaactagc caagcgtggt ggcacatgcc tgtaatcccc gctactcggg aggctgaggc   6300

aggagaatca cttgaacctg ggaggtggag gttgcgggtg agccgagatc gtgccatcgc   6360

attccagcct gggcaataag agtgaaactc cgtctcaaaa aaaaaaaaaa aattgccaca   6420

tggctagagt ggtatgtaag ggggtgtggc agatattgag atgagggagg tgacaggggt   6480

catataacgc agggccttct gcagggtggt ggggaggagt ttggaatttt tttttttttt   6540

gagacagagt cactcttctc gcccaagctg tagtgcagtg cagcagtctt ggctcactgc   6600

aactctgcct cccaggttca agtgattctc ctgcctcaac cgcctgagta gctgagatta   6660

caggcgtgca tgcccggcta attttgtagt tttagtagag acgggcttcc accatgttgg   6720

ccaggctggt ctcaaactcc tgacctcagg tgatctgctc acatcagcct ctcaaagtgc   6780

tgggattata ggcatgagcc accgtgcctg gcttggattt tatcctaaat gcctctctca   6840

ttaccccaga aggtaacata atatttatct atgaagtgac atcatggacc tcctggaaaa   6900

atctgggcca gggttttggg ttttttaatt tattttattt tatttttttt agagatgggg   6960

gtctcactat gtttcctagg ctggtcttga actcctgggt tcaaatgatc ctcccacctc   7020

agcctcccaa agtactggga ttatagtgct ggtgtaaacc actgcacctg gccatggcca   7080

ggattaaagg gagaatgacc aaggtatatt gaactcctat gcacccttca ataccctgtt   7140

ccatttaccc ttttgtaggg ccttgctgat gcttcagcca aaacccctgt cccctggccc   7200

tgatgtactc ctctgcctcc attgtgatca cagggaccaa gtgtatctgt gcctctatga   7260

ctgggagtgg agggggaatt ggtgagtatt caatgagtca tatctatgta actatttata   7320

ttggcttcaa cagggctctg aagcagaaga tctggcctgg catcccgagc ccagagagcg   7380

agtttgaagg cctcttcacc acccacaagg gtaacttcca ggtaggtggc ctggttgtcc   7440

cctcagtgcc tgggcttccc tgcttcttgc agccaaactg caggcctctc tgagcaggtt   7500

ggtgctattt cttcagctgt ggctgtacca gaatgatggc tgcctgtggt ggagcccctg   7560

cacccccttc acggaggacc cacctgcttc cctggaagtc ctctcagagc gctgctgggg   7620

gacgatgcag gcagtggagc cggggacaga tgatgagggc cccctgctgg agccagtggg   7680

cagtgagcat gcccaggata cctatctggt gctggacaaa tggttgctgc cccggaaccc   7740

gcccagtgag gacctcccag ggcctggtgg cagtgtggac atagtggcca tggatgaagg   7800

ctcagaagca tcctcctgct catctgcttt ggcctcgaag cccagcccag agggagcctc   7860

tgctgccagc tttgagtaca ctatcctgga ccccagctcc cagctcttgc gtccatggac   7920

actgtgccct gagctgcccc ctaccccacc ccacctaaag tacctgtacc tttttgtatc   7980

tgactctggc atctcaactg actacagctc aggggactcc cagggagccc aagggggctt   8040

atccgatggc ccctactcca acccttatga gaacagcctt atcccagccg ctgagcctct   8100

gccccccagc tatgtggctt gctcttagga caccaggctg cagatgatca gggatccaat   8160

atgactcaga gaaccagtgc agactcaaga cttatggaac agggatggcg aggcctctct   8220

caggagcagg ggcattgctg attttgtctg cccaatccat cctgctcagg aaaccacaac   8280

cttgcagtat ttttaaatat gtatagtttt tttttgtatc tatatatata tatacacata   8340

tgtatgtaag tttttctacc atgatttcta caaacaccct ttaagtccca tcttcccctg   8400

ggcataggcc atagggatag aagttaaagt tcttgagctt attcagaagc tggatctgca   8460

atctgaatgc tactcataac ataacaaaat agtatgttaa acagctctta aatcttactg   8520

gcttaccaca ttaaatgatt tctctctcct aactcagctc aaatgggcag ccatccatgg   8580

atgagtcaga ggttcagact cttccagtct gtagctctac cttctcttag ggtacttaga   8640

tggatcc                                                             8647


