                         SEQUENCE LISTING

<110>  Neotropix, Inc.
       Hallenbeck, Paul
       Police, Seshidar Reddy
       Hales, Laura
       Burroughs, Kevin
 
<120>  MONOCLONAL ANTIBODY THAT RECOGNIZES A SENECA VALLEY VIRUS (SVV) 
       CELLULAR RECEPTOR AND USES THEREOF

<130>  287037-132 WO1

<140>  TBD
<141>  2008-03-13

<150>  US 60/906,735
<151>  2007-03-13

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  7290
<212>  DNA
<213>  Seneca Valley Virus

<400>  1
tttgaaatgg ggggctgggc cctgatgccc agtccttcct ttccccttcc ggggggttaa     60

ccggctgtgt ttgctagagg cacagagggg caacatccaa cctgcttttg cggggaacgg    120

tgcggctccg attcctgcgt cgccaaaggt gttagcgcac ccaaacggcg cacctaccaa    180

tgttattggt gtggtctgcg agttctagcc tactcgtttc tcccccgacc attcactcac    240

ccacgaaaag tgtgttgtaa ccataagatt taacccccgc acgggatgtg cgataaccgt    300

aagactggct caagcgcgga aagcgctgta accacatgct gttagtccct ttatggctgc    360

aagatggcta cccacctcgg atcactgaac tggagctcga ccctccttag taagggaacc    420

gagaggcctt cgtgcaacaa gctccgacac agagtccacg tgactgctac caccatgagt    480

acatggttct cccctctcga cccaggactt ctttttgaat atccacggct cgatccagag    540

ggtggggcat gacccctagc atagcgagct acagcgggaa ctgtagctag gccttagcgt    600

gccttggata ctgcctgata gggcgacggc ctagtcgtgt cggttctata ggtagcacat    660

acaaatatgc agaactctca tttttctttc gatacagcct ctggcacctt tgaagatgta    720

accggaacaa aagtcaagat cgttgaatac cccagatcgg tgaacaatgg tgtttacgat    780

tcgtctactc atttggagat actgaaccta cagggtgaaa ttgaaatttt aaggtctttc    840

aatgaatacc aaattcgcgc cgccaaacaa caactcggac tggacatcgt gtacgaacta    900

cagggtaatg ttcagacaac gtcaaagaat gattttgatt cccgtggcaa taatggtaac    960

atgaccttca attactacgc aaacacttat cagaattcag tagacttctc gacctcctcg   1020

tcggcgtcag gcgccggacc cgggaactcc cggggcggat tagcgggtct cctcacaaat   1080

ttcagtggaa tcttgaaccc tcttggctac ctcaaagatc acaacaccga agaaatggaa   1140

aactctgctg atcgagtcac aacgcaaacg gcgggcaaca ctgccataaa cacgcaatca   1200

tcattgggtg tgttgtgtgc ctacgttgaa gacccgacca aatctgatcc tccgtccagc   1260

agcacagatc aacccaccac cactttcact gccatcgaca ggtggtacac tggacgtctc   1320

aattcttgga caaaagctgt aaaaaccttc tcttttcagg ccgtcccgct tcccggggcc   1380

tttctgtcta ggcagggagg cctcaacgga ggggccttca cagctaccct acatagacac   1440

tttttgatga agtgcgggtg gcaggtgcag gtccaatgta atttgacaca attccaccaa   1500

ggcgctcttc ttgttgccat ggttcctgaa accacccttg atgtcaagcc cgacggtaag   1560

gcaaagagct tacaggagct gaatgaagaa cagtgggtgg aaatgtctga cgattaccgg   1620

accgggaaaa acatgccttt tcagtctctt ggcacatact atcggccccc taactggact   1680

tggggtccca atttcatcaa cccctatcaa gtaacggttt tcccacacca aattctgaac   1740

gcgagaacct ctacctcggt agacataaac gtcccataca tcggggagac ccccacgcaa   1800

tcctcagaga cacagaactc ctggaccctc ctcgttatgg tgctcgttcc cctagactat   1860

aaggaaggag ccacaactga cccagaaatt acattttctg taaggcctac aagtccctac   1920

ttcaatgggc ttcgcaaccg ctacacggcc gggacggacg aagaacaggg gcccattcct   1980

acggcaccca gagaaaattc gcttatgttt ctctcaaccc tccctgacga cactgtccct   2040

gcttacggga atgtgcgtac ccctcctgtc aattacctcc ctggtgaaat aaccgacctt   2100

ttgcaactgg cccgcatacc cactctcatg gcatttgagc gggtgcctga acccgtgcct   2160

gcctcagaca catatgtgcc ctacgttgcc gttcccaccc agttcgatga caggcctctc   2220

atctccttcc cgatcaccct ttcagatccc gtctatcaga acaccctggt tggcgccatc   2280

agttcaaatt tcgccaatta ccgtgggtgt atccaaatca ctctgacatt ttgtggaccc   2340

atgatggcga gagggaaatt cctgctctcg tattctcccc caaatggaac gcaaccacag   2400

actctttccg aagctatgca gtgcacatac tctatttggg acataggctt gaactctagt   2460

tggaccttcg tcgtccccta catctcgccc agtgactacc gtgaaactcg agccattacc   2520

aactcggttt actccgctga tggttggttt agcctgcaca agttgaccaa aattactcta   2580

ccacctgact gtccgcaaag tccctgcatt ctctttttcg cttctgctgg tgaggattac   2640

actctccgtc tccccgttga ttgtaatcct tcctatgtgt tccactccac cgacaacgcc   2700

gagaccgggg ttattgaggc gggtaacact gacaccgatt tctctggtga actggcggct   2760

cctggctcta accacactaa tgtcaagttc ctgtttgatc gatctcgatt attgaatgta   2820

atcaaggtac tggagaagga cgccgttttc ccccgccctt tccctacaca agaaggtgcg   2880

cagcaggatg atggttactt ttgtcttctg accccccgcc caacagtcgc ttcccgaccc   2940

gccactcgtt tcggcctgta cgccaatccg tccggcagtg gtgttcttgc taacacttca   3000

ctggacttca atttttatag cttggcctgt ttcacttact ttagatcgga ccttgaggtt   3060

acggtggtct cactagagcc ggatctggaa tttgctgtag ggtggtttcc ttctggcagt   3120

gaataccagg cttccagctt tgtctacgac cagctgcatg tgcccttcca ctttactggg   3180

cgcactcccc gcgctttcgc tagcaagggt gggaaggtat ctttcgtgct cccttggaac   3240

tctgtctcgt ctgtgctccc cgtgcgctgg gggggggctt ccaagctctc ttctgctacg   3300

cggggtctac cggcgcatgc tgattggggg actatttacg cctttgtccc ccgtcctaat   3360

gagaagaaaa gcaccgctgt aaaacacgtg gccgtgtaca ttcggtacaa gaacgcacgt   3420

gcctggtgcc ccagcatgct tccctttcgc agctacaagc agaagatgct gatgcaatct   3480

ggcgatatcg agaccaatcc tggtcctgct tctgacaacc caattttgga gtttcttgaa   3540

gcagaaaatg atctagtcac tctggcctct ctctggaaga tggtgcactc tgttcaacag   3600

acctggagaa agtatgtgaa gaacgatgat ttttggccca atttactcag cgagctagtg   3660

ggggaaggct ctgtcgcctt ggccgccacg ctatccaacc aagcttcagt aaaggctctt   3720

ttgggcctgc actttctctc tcgggggctc aattacactg acttttactc tttactgata   3780

gagaaatgct ctagtttctt taccgtagaa ccacctcctc caccagctga aaacctgatg   3840

accaagccct cagtgaagtc gaaattccga aaactgttta agatgcaagg acccatggac   3900

aaagtcaaag actggaacca aatagctgcc ggcttgaaga attttcaatt tgttcgtgac   3960

ctagtcaaag aggtggtcga ttggctgcag gcctggatca acaaagagaa agccagccct   4020

gtcctccagt accagttgga gatgaagaag ctcgggcctg tggccttggc tcatgacgct   4080

ttcatggctg gttccgggcc ccctcttagc gacgaccaga ttgaatacct ccagaacctc   4140

aaatctcttg ccctaacact ggggaagact aatttggccc aaagtctcac cactatgatc   4200

aatgccaaac aaagttcagc ccaacgagtt gaacccgttg tggtggtcct tagaggcaag   4260

ccgggatgcg gcaagagctt ggcctctacg ttgattgccc aggctgtgtc caagcgcctc   4320

tatggctccc aaagtgtata ttctcttccc ccagatccag atttcttcga tggatacaaa   4380

ggacagttcg tgaccttgat ggatgatttg ggacaaaacc cggatggaca agatttctcc   4440

accttttgtc agatggtgtc gaccgcccaa tttctcccca acatggcgga ccttgcagag   4500

aaagggcgtc cctttacctc caatctcatc attgcaacta caaatctccc ccacttcagt   4560

cctgtcacca ttgctgatcc ttctgcagtc tctcgccgta tcaactacga tctgactcta   4620

gaagtatctg aggcctacaa gaaacacaca cggctgaatt ttgacttggc tttcaggcgc   4680

acagacgccc cccccattta tccttttgct gcccatgtgc cctttgtgga cgtagctgtg   4740

cgcttcaaaa atggtcacca gaattttaat ctcctagagt tggtcgattc catttgtaca   4800

gacattcgag ccaagcaaca aggtgcccga aacatgcaga ctctggttct acagagcccc   4860

aacgagaatg atgacacccc cgtcgacgag gcgttgggta gagttctctc ccccgctgcg   4920

gtcgatgagg cgcttgtcga cctcactcca gaggccgacc cggttggccg tttggctatt   4980

cttgccaagc taggtcttgc cctagctgcg gtcacccctg gtctgataat cttggcagtg   5040

ggactctaca ggtacttctc tggctctgat gcagaccaag aagaaacaga aagtgaggga   5100

tctgtcaagg cacccaggag cgaaaatgct tatgacggcc cgaagaaaaa ctctaagccc   5160

cctggagcac tctctctcat ggaaatgcaa cagcccaacg tggacatggg ctttgaggct   5220

gcggtcgcta agaaagtggt cgtccccatt accttcatgg ttcccaacag accttctggg   5280

cttacacagt ccgctcttct ggtgaccggc cggaccttcc taatcaatga acatacatgg   5340

tccaatccct cctggaccag cttcacaatc cgcggtgagg tacacactcg tgatgagccc   5400

ttccaaacgg ttcatttcac tcaccacggt attcccacag atctgatgat ggtacgtctc   5460

ggaccgggca attctttccc taacaatcta gacaagtttg gacttgacca gatgccggca   5520

cgcaactccc gtgtggttgg cgtttcgtcc agttacggaa acttcttctt ctctggaaat   5580

ttcctcggat ttgttgattc catcacctct gaacaaggaa cttacgcaag actctttagg   5640

tacagggtga cgacctacaa aggatggtgc ggctcggccc tggtctgtga ggccggtggc   5700

gtccgacgca tcattggcct gcattctgct ggcgccgccg gtatcggcgc cgggacctat   5760

atctcaaaat taggactaat caaagccctg aaacacctcg gtgaaccttt ggccacaatg   5820

caaggactga tgactgaatt agagcctgga atcaccgtac atgtaccccg gaaatccaaa   5880

ttgagaaaga cgaccgcaca cgcggtgtac aaaccggagt ttgagcctgc tgtgttgtca   5940

aaatttgatc ccagactgaa caaggatgtt gacttggatg aagtaatttg gtctaaacac   6000

actgccaatg tcccttacca acctcctttg ttctacacat acatgtcaga gtacgctcat   6060

cgagtcttct ccttcttggg gaaagacaat gacattctga ccgtcaaaga agcaattctg   6120

ggcatccccg gactagaccc catggatccc cacacagctc cgggtctgcc ttacgccatc   6180

aacggccttc gacgtactga tctcgtcgat tttgtgaacg gtacagtaga tgcggcgctg   6240

gctgtacaaa tccagaaatt cttagacggt gactactctg accatgtctt ccaaactttt   6300

ctgaaagatg agatcagacc ctcagagaaa gtccgagcgg gaaaaacccg cattgttgat   6360

gtgccctccc tggcgcattg cattgtgggc agaatgttgc ttgggcgctt tgctgccaag   6420

tttcaatccc atcctggctt tctcctcggc tctgctatcg ggtctgaccc tgatgttttc   6480

tggaccgtca taggggctca actcgagggg agaaagaaca cgtatgacgt ggactacagt   6540

gcctttgact cttcacacgg cactggctcc ttcgaggctc tcatctctca ctttttcacc   6600

gtggacaatg gttttagccc tgcgctggga ccgtatctca gatccctggc tgtctcggtg   6660

cacgcttacg gcgagcgtcg catcaagatt accggtggcc tcccctccgg ttgtgccgcg   6720

accagcctgc tgaacacagt gctcaacaat gtgatcatca ggactgctct ggcattgact   6780

tacaaggaat ttgaatatga catggttgat atcatcgcct acggtgacga ccttctggtt   6840

ggcacggatt acgatctgga cttcaatgag gtggcacgac gcgctgccaa gttggggtat   6900

aagatgactc ctgccaacaa gggttctgtc ttccctccga cttcctctct ttccgatgct   6960

gtttttctaa agcgcaaatt cgtccaaaac aacgacggct tatacaaacc agttatggat   7020

ttaaagaatt tggaagccat gctctcctac ttcaaaccag gaacactact cgagaagctg   7080

caatctgttt ctatgttggc tcaacattct ggaaaagaag aatatgatag attgatgcac   7140

cccttcgctg actacggtgc cgtaccgagt cacgagtacc tgcaggcaag atggagggcc   7200

ttgttcgact gacccagata gcccaaggcg cttcggtgct gccggcgatt ctgggagaac   7260

tcagtcggaa cagaaaaggg aaaaaaaaaa                                    7290


<210>  2
<211>  2181
<212>  PRT
<213>  Seneca Valley Virus

<400>  2

Met Gln Asn Ser His Phe Ser Phe Asp Thr Ala Ser Gly Thr Phe Glu 
1               5                   10                  15      


Asp Val Thr Gly Thr Lys Val Lys Ile Val Glu Tyr Pro Arg Ser Val 
            20                  25                  30          


Asn Asn Gly Val Tyr Asp Ser Ser Thr His Leu Glu Ile Leu Asn Leu 
        35                  40                  45              


Gln Gly Glu Ile Glu Ile Leu Arg Ser Phe Asn Glu Tyr Gln Ile Arg 
    50                  55                  60                  


Ala Ala Lys Gln Gln Leu Gly Leu Asp Ile Val Tyr Glu Leu Gln Gly 
65                  70                  75                  80  


Asn Val Gln Thr Thr Ser Lys Asn Asp Phe Asp Ser Arg Gly Asn Asn 
                85                  90                  95      


Gly Asn Met Thr Phe Asn Tyr Tyr Ala Asn Thr Tyr Gln Asn Ser Val 
            100                 105                 110         


Asp Phe Ser Thr Ser Ser Ser Ala Ser Gly Ala Gly Pro Gly Asn Ser 
        115                 120                 125             


Arg Gly Gly Leu Ala Gly Leu Leu Thr Asn Phe Ser Gly Ile Leu Asn 
    130                 135                 140                 


Pro Leu Gly Tyr Leu Lys Asp His Asn Thr Glu Glu Met Glu Asn Ser 
145                 150                 155                 160 


Ala Asp Arg Val Thr Thr Gln Thr Ala Gly Asn Thr Ala Ile Asn Thr 
                165                 170                 175     


Gln Ser Ser Leu Gly Val Leu Cys Ala Tyr Val Glu Asp Pro Thr Lys 
            180                 185                 190         


Ser Asp Pro Pro Ser Ser Ser Thr Asp Gln Pro Thr Thr Thr Phe Thr 
        195                 200                 205             


Ala Ile Asp Arg Trp Tyr Thr Gly Arg Leu Asn Ser Trp Thr Lys Ala 
    210                 215                 220                 


Val Lys Thr Phe Ser Phe Gln Ala Val Pro Leu Pro Gly Ala Phe Leu 
225                 230                 235                 240 


Ser Arg Gln Gly Gly Leu Asn Gly Gly Ala Phe Thr Ala Thr Leu His 
                245                 250                 255     


Arg His Phe Leu Met Lys Cys Gly Trp Gln Val Gln Val Gln Cys Asn 
            260                 265                 270         


Leu Thr Gln Phe His Gln Gly Ala Leu Leu Val Ala Met Val Pro Glu 
        275                 280                 285             


Thr Thr Leu Asp Val Lys Pro Asp Gly Lys Ala Lys Ser Leu Gln Glu 
    290                 295                 300                 


Leu Asn Glu Glu Gln Trp Val Glu Met Ser Asp Asp Tyr Arg Thr Gly 
305                 310                 315                 320 


Lys Asn Met Pro Phe Gln Ser Leu Gly Thr Tyr Tyr Arg Pro Pro Asn 
                325                 330                 335     


Trp Thr Trp Gly Pro Asn Phe Ile Asn Pro Tyr Gln Val Thr Val Phe 
            340                 345                 350         


Pro His Gln Ile Leu Asn Ala Arg Thr Ser Thr Ser Val Asp Ile Asn 
        355                 360                 365             


Val Pro Tyr Ile Gly Glu Thr Pro Thr Gln Ser Ser Glu Thr Gln Asn 
    370                 375                 380                 


Ser Trp Thr Leu Leu Val Met Val Leu Val Pro Leu Asp Tyr Lys Glu 
385                 390                 395                 400 


Gly Ala Thr Thr Asp Pro Glu Ile Thr Phe Ser Val Arg Pro Thr Ser 
                405                 410                 415     


Pro Tyr Phe Asn Gly Leu Arg Asn Arg Tyr Thr Ala Gly Thr Asp Glu 
            420                 425                 430         


Glu Gln Gly Pro Ile Pro Thr Ala Pro Arg Glu Asn Ser Leu Met Phe 
        435                 440                 445             


Leu Ser Thr Leu Pro Asp Asp Thr Val Pro Ala Tyr Gly Asn Val Arg 
    450                 455                 460                 


Thr Pro Pro Val Asn Tyr Leu Pro Gly Glu Ile Thr Asp Leu Leu Gln 
465                 470                 475                 480 


Leu Ala Arg Ile Pro Thr Leu Met Ala Phe Glu Arg Val Pro Glu Pro 
                485                 490                 495     


Val Pro Ala Ser Asp Thr Tyr Val Pro Tyr Val Ala Val Pro Thr Gln 
            500                 505                 510         


Phe Asp Asp Arg Pro Leu Ile Ser Phe Pro Ile Thr Leu Ser Asp Pro 
        515                 520                 525             


Val Tyr Gln Asn Thr Leu Val Gly Ala Ile Ser Ser Asn Phe Ala Asn 
    530                 535                 540                 


Tyr Arg Gly Cys Ile Gln Ile Thr Leu Thr Phe Cys Gly Pro Met Met 
545                 550                 555                 560 


Ala Arg Gly Lys Phe Leu Leu Ser Tyr Ser Pro Pro Asn Gly Thr Gln 
                565                 570                 575     


Pro Gln Thr Leu Ser Glu Ala Met Gln Cys Thr Tyr Ser Ile Trp Asp 
            580                 585                 590         


Ile Gly Leu Asn Ser Ser Trp Thr Phe Val Val Pro Tyr Ile Ser Pro 
        595                 600                 605             


Ser Asp Tyr Arg Glu Thr Arg Ala Ile Thr Asn Ser Val Tyr Ser Ala 
    610                 615                 620                 


Asp Gly Trp Phe Ser Leu His Lys Leu Thr Lys Ile Thr Leu Pro Pro 
625                 630                 635                 640 


Asp Cys Pro Gln Ser Pro Cys Ile Leu Phe Phe Ala Ser Ala Gly Glu 
                645                 650                 655     


Asp Tyr Thr Leu Arg Leu Pro Val Asp Cys Asn Pro Ser Tyr Val Phe 
            660                 665                 670         


His Ser Thr Asp Asn Ala Glu Thr Gly Val Ile Glu Ala Gly Asn Thr 
        675                 680                 685             


Asp Thr Asp Phe Ser Gly Glu Leu Ala Ala Pro Gly Ser Asn His Thr 
    690                 695                 700                 


Asn Val Lys Phe Leu Phe Asp Arg Ser Arg Leu Leu Asn Val Ile Lys 
705                 710                 715                 720 


Val Leu Glu Lys Asp Ala Val Phe Pro Arg Pro Phe Pro Thr Gln Glu 
                725                 730                 735     


Gly Ala Gln Gln Asp Asp Gly Tyr Phe Cys Leu Leu Thr Pro Arg Pro 
            740                 745                 750         


Thr Val Ala Ser Arg Pro Ala Thr Arg Phe Gly Leu Tyr Ala Asn Pro 
        755                 760                 765             


Ser Gly Ser Gly Val Leu Ala Asn Thr Ser Leu Asp Phe Asn Phe Tyr 
    770                 775                 780                 


Ser Leu Ala Cys Phe Thr Tyr Phe Arg Ser Asp Leu Glu Val Thr Val 
785                 790                 795                 800 


Val Ser Leu Glu Pro Asp Leu Glu Phe Ala Val Gly Trp Phe Pro Ser 
                805                 810                 815     


Gly Ser Glu Tyr Gln Ala Ser Ser Phe Val Tyr Asp Gln Leu His Val 
            820                 825                 830         


Pro Phe His Phe Thr Gly Arg Thr Pro Arg Ala Phe Ala Ser Lys Gly 
        835                 840                 845             


Gly Lys Val Ser Phe Val Leu Pro Trp Asn Ser Val Ser Ser Val Leu 
    850                 855                 860                 


Pro Val Arg Trp Gly Gly Ala Ser Lys Leu Ser Ser Ala Thr Arg Gly 
865                 870                 875                 880 


Leu Pro Ala His Ala Asp Trp Gly Thr Ile Tyr Ala Phe Val Pro Arg 
                885                 890                 895     


Pro Asn Glu Lys Lys Ser Thr Ala Val Lys His Val Ala Val Tyr Ile 
            900                 905                 910         


Arg Tyr Lys Asn Ala Arg Ala Trp Cys Pro Ser Met Leu Pro Phe Arg 
        915                 920                 925             


Ser Tyr Lys Gln Lys Met Leu Met Gln Ser Gly Asp Ile Glu Thr Asn 
    930                 935                 940                 


Pro Gly Pro Ala Ser Asp Asn Pro Ile Leu Glu Phe Leu Glu Ala Glu 
945                 950                 955                 960 


Asn Asp Leu Val Thr Leu Ala Ser Leu Trp Lys Met Val His Ser Val 
                965                 970                 975     


Gln Gln Thr Trp Arg Lys Tyr Val Lys Asn Asp Asp Phe Trp Pro Asn 
            980                 985                 990         


Leu Leu Ser Glu Leu Val Gly Glu  Gly Ser Val Ala Leu  Ala Ala Thr 
        995                 1000                 1005             


Leu Ser  Asn Gln Ala Ser Val  Lys Ala Leu Leu Gly  Leu His Phe 
    1010                 1015                 1020             


Leu Ser  Arg Gly Leu Asn Tyr  Thr Asp Phe Tyr Ser  Leu Leu Ile 
    1025                 1030                 1035             


Glu Lys  Cys Ser Ser Phe Phe  Thr Val Glu Pro Pro  Pro Pro Pro 
    1040                 1045                 1050             


Ala Glu  Asn Leu Met Thr Lys  Pro Ser Val Lys Ser  Lys Phe Arg 
    1055                 1060                 1065             


Lys Leu  Phe Lys Met Gln Gly  Pro Met Asp Lys Val  Lys Asp Trp 
    1070                 1075                 1080             


Asn Gln  Ile Ala Ala Gly Leu  Lys Asn Phe Gln Phe  Val Arg Asp 
    1085                 1090                 1095             


Leu Val  Lys Glu Val Val Asp  Trp Leu Gln Ala Trp  Ile Asn Lys 
    1100                 1105                 1110             


Glu Lys  Ala Ser Pro Val Leu  Gln Tyr Gln Leu Glu  Met Lys Lys 
    1115                 1120                 1125             


Leu Gly  Pro Val Ala Leu Ala  His Asp Ala Phe Met  Ala Gly Ser 
    1130                 1135                 1140             


Gly Pro  Pro Leu Ser Asp Asp  Gln Ile Glu Tyr Leu  Gln Asn Leu 
    1145                 1150                 1155             


Lys Ser  Leu Ala Leu Thr Leu  Gly Lys Thr Asn Leu  Ala Gln Ser 
    1160                 1165                 1170             


Leu Thr  Thr Met Ile Asn Ala  Lys Gln Ser Ser Ala  Gln Arg Val 
    1175                 1180                 1185             


Glu Pro  Val Val Val Val Leu  Arg Gly Lys Pro Gly  Cys Gly Lys 
    1190                 1195                 1200             


Ser Leu  Ala Ser Thr Leu Ile  Ala Gln Ala Val Ser  Lys Arg Leu 
    1205                 1210                 1215             


Tyr Gly  Ser Gln Ser Val Tyr  Ser Leu Pro Pro Asp  Pro Asp Phe 
    1220                 1225                 1230             


Phe Asp  Gly Tyr Lys Gly Gln  Phe Val Thr Leu Met  Asp Asp Leu 
    1235                 1240                 1245             


Gly Gln  Asn Pro Asp Gly Gln  Asp Phe Ser Thr Phe  Cys Gln Met 
    1250                 1255                 1260             


Val Ser  Thr Ala Gln Phe Leu  Pro Asn Met Ala Asp  Leu Ala Glu 
    1265                 1270                 1275             


Lys Gly  Arg Pro Phe Thr Ser  Asn Leu Ile Ile Ala  Thr Thr Asn 
    1280                 1285                 1290             


Leu Pro  His Phe Ser Pro Val  Thr Ile Ala Asp Pro  Ser Ala Val 
    1295                 1300                 1305             


Ser Arg  Arg Ile Asn Tyr Asp  Leu Thr Leu Glu Val  Ser Glu Ala 
    1310                 1315                 1320             


Tyr Lys  Lys His Thr Arg Leu  Asn Phe Asp Leu Ala  Phe Arg Arg 
    1325                 1330                 1335             


Thr Asp  Ala Pro Pro Ile Tyr  Pro Phe Ala Ala His  Val Pro Phe 
    1340                 1345                 1350             


Val Asp  Val Ala Val Arg Phe  Lys Asn Gly His Gln  Asn Phe Asn 
    1355                 1360                 1365             


Leu Leu  Glu Leu Val Asp Ser  Ile Cys Thr Asp Ile  Arg Ala Lys 
    1370                 1375                 1380             


Gln Gln  Gly Ala Arg Asn Met  Gln Thr Leu Val Leu  Gln Ser Pro 
    1385                 1390                 1395             


Asn Glu  Asn Asp Asp Thr Pro  Val Asp Glu Ala Leu  Gly Arg Val 
    1400                 1405                 1410             


Leu Ser  Pro Ala Ala Val Asp  Glu Ala Leu Val Asp  Leu Thr Pro 
    1415                 1420                 1425             


Glu Ala  Asp Pro Val Gly Arg  Leu Ala Ile Leu Ala  Lys Leu Gly 
    1430                 1435                 1440             


Leu Ala  Leu Ala Ala Val Thr  Pro Gly Leu Ile Ile  Leu Ala Val 
    1445                 1450                 1455             


Gly Leu  Tyr Arg Tyr Phe Ser  Gly Ser Asp Ala Asp  Gln Glu Glu 
    1460                 1465                 1470             


Thr Glu  Ser Glu Gly Ser Val  Lys Ala Pro Arg Ser  Glu Asn Ala 
    1475                 1480                 1485             


Tyr Asp  Gly Pro Lys Lys Asn  Ser Lys Pro Pro Gly  Ala Leu Ser 
    1490                 1495                 1500             


Leu Met  Glu Met Gln Gln Pro  Asn Val Asp Met Gly  Phe Glu Ala 
    1505                 1510                 1515             


Ala Val  Ala Lys Lys Val Val  Val Pro Ile Thr Phe  Met Val Pro 
    1520                 1525                 1530             


Asn Arg  Pro Ser Gly Leu Thr  Gln Ser Ala Leu Leu  Val Thr Gly 
    1535                 1540                 1545             


Arg Thr  Phe Leu Ile Asn Glu  His Thr Trp Ser Asn  Pro Ser Trp 
    1550                 1555                 1560             


Thr Ser  Phe Thr Ile Arg Gly  Glu Val His Thr Arg  Asp Glu Pro 
    1565                 1570                 1575             


Phe Gln  Thr Val His Phe Thr  His His Gly Ile Pro  Thr Asp Leu 
    1580                 1585                 1590             


Met Met  Val Arg Leu Gly Pro  Gly Asn Ser Phe Pro  Asn Asn Leu 
    1595                 1600                 1605             


Asp Lys  Phe Gly Leu Asp Gln  Met Pro Ala Arg Asn  Ser Arg Val 
    1610                 1615                 1620             


Val Gly  Val Ser Ser Ser Tyr  Gly Asn Phe Phe Phe  Ser Gly Asn 
    1625                 1630                 1635             


Phe Leu  Gly Phe Val Asp Ser  Ile Thr Ser Glu Gln  Gly Thr Tyr 
    1640                 1645                 1650             


Ala Arg  Leu Phe Arg Tyr Arg  Val Thr Thr Tyr Lys  Gly Trp Cys 
    1655                 1660                 1665             


Gly Ser  Ala Leu Val Cys Glu  Ala Gly Gly Val Arg  Arg Ile Ile 
    1670                 1675                 1680             


Gly Leu  His Ser Ala Gly Ala  Ala Gly Ile Gly Ala  Gly Thr Tyr 
    1685                 1690                 1695             


Ile Ser  Lys Leu Gly Leu Ile  Lys Ala Leu Lys His  Leu Gly Glu 
    1700                 1705                 1710             


Pro Leu  Ala Thr Met Gln Gly  Leu Met Thr Glu Leu  Glu Pro Gly 
    1715                 1720                 1725             


Ile Thr  Val His Val Pro Arg  Lys Ser Lys Leu Arg  Lys Thr Thr 
    1730                 1735                 1740             


Ala His  Ala Val Tyr Lys Pro  Glu Phe Glu Pro Ala  Val Leu Ser 
    1745                 1750                 1755             


Lys Phe  Asp Pro Arg Leu Asn  Lys Asp Val Asp Leu  Asp Glu Val 
    1760                 1765                 1770             


Ile Trp  Ser Lys His Thr Ala  Asn Val Pro Tyr Gln  Pro Pro Leu 
    1775                 1780                 1785             


Phe Tyr  Thr Tyr Met Ser Glu  Tyr Ala His Arg Val  Phe Ser Phe 
    1790                 1795                 1800             


Leu Gly  Lys Asp Asn Asp Ile  Leu Thr Val Lys Glu  Ala Ile Leu 
    1805                 1810                 1815             


Gly Ile  Pro Gly Leu Asp Pro  Met Asp Pro His Thr  Ala Pro Gly 
    1820                 1825                 1830             


Leu Pro  Tyr Ala Ile Asn Gly  Leu Arg Arg Thr Asp  Leu Val Asp 
    1835                 1840                 1845             


Phe Val  Asn Gly Thr Val Asp  Ala Ala Leu Ala Val  Gln Ile Gln 
    1850                 1855                 1860             


Lys Phe  Leu Asp Gly Asp Tyr  Ser Asp His Val Phe  Gln Thr Phe 
    1865                 1870                 1875             


Leu Lys  Asp Glu Ile Arg Pro  Ser Glu Lys Val Arg  Ala Gly Lys 
    1880                 1885                 1890             


Thr Arg  Ile Val Asp Val Pro  Ser Leu Ala His Cys  Ile Val Gly 
    1895                 1900                 1905             


Arg Met  Leu Leu Gly Arg Phe  Ala Ala Lys Phe Gln  Ser His Pro 
    1910                 1915                 1920             


Gly Phe  Leu Leu Gly Ser Ala  Ile Gly Ser Asp Pro  Asp Val Phe 
    1925                 1930                 1935             


Trp Thr  Val Ile Gly Ala Gln  Leu Glu Gly Arg Lys  Asn Thr Tyr 
    1940                 1945                 1950             


Asp Val  Asp Tyr Ser Ala Phe  Asp Ser Ser His Gly  Thr Gly Ser 
    1955                 1960                 1965             


Phe Glu  Ala Leu Ile Ser His  Phe Phe Thr Val Asp  Asn Gly Phe 
    1970                 1975                 1980             


Ser Pro  Ala Leu Gly Pro Tyr  Leu Arg Ser Leu Ala  Val Ser Val 
    1985                 1990                 1995             


His Ala  Tyr Gly Glu Arg Arg  Ile Lys Ile Thr Gly  Gly Leu Pro 
    2000                 2005                 2010             


Ser Gly  Cys Ala Ala Thr Ser  Leu Leu Asn Thr Val  Leu Asn Asn 
    2015                 2020                 2025             


Val Ile  Ile Arg Thr Ala Leu  Ala Leu Thr Tyr Lys  Glu Phe Glu 
    2030                 2035                 2040             


Tyr Asp  Met Val Asp Ile Ile  Ala Tyr Gly Asp Asp  Leu Leu Val 
    2045                 2050                 2055             


Gly Thr  Asp Tyr Asp Leu Asp  Phe Asn Glu Val Ala  Arg Arg Ala 
    2060                 2065                 2070             


Ala Lys  Leu Gly Tyr Lys Met  Thr Pro Ala Asn Lys  Gly Ser Val 
    2075                 2080                 2085             


Phe Pro  Pro Thr Ser Ser Leu  Ser Asp Ala Val Phe  Leu Lys Arg 
    2090                 2095                 2100             


Lys Phe  Val Gln Asn Asn Asp  Gly Leu Tyr Lys Pro  Val Met Asp 
    2105                 2110                 2115             


Leu Lys  Asn Leu Glu Ala Met  Leu Ser Tyr Phe Lys  Pro Gly Thr 
    2120                 2125                 2130             


Leu Leu  Glu Lys Leu Gln Ser  Val Ser Met Leu Ala  Gln His Ser 
    2135                 2140                 2145             


Gly Lys  Glu Glu Tyr Asp Arg  Leu Met His Pro Phe  Ala Asp Tyr 
    2150                 2155                 2160             


Gly Ala  Val Pro Ser His Glu  Tyr Leu Gln Ala Arg  Trp Arg Ala 
    2165                 2170                 2175             


Leu Phe  Asp 
    2180     


<210>  3
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


