                         SEQUENCE LISTING

<110>  JOHNSTON, RANDY N.
       MANBOK, KIM
       HOLLENBERG, MORLEY D.
       HANSEN, KRISTINA K.
 
<120>  INHIBITION OF VIRAL REPLICATION

<130>  UNTI:014WO

<140>  UNKNOWN
<141>  2008-03-13

<150>  60/906,706
<151>  2007-03-13

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  1463
<212>  DNA
<213>  Mammalian orthoreovirus


<220>
<221>  CDS
<222>  (14)..(1426)

<400>  1
gctattcgcg cct atg gat gca tct ctc att aca gag ata cgg aaa ata        49
               Met Asp Ala Ser Leu Ile Thr Glu Ile Arg Lys Ile          
               1               5                   10                   

gta ctc caa cta tct gta tca agc aat ggc tcc cag tca aaa gaa atc       97
Val Leu Gln Leu Ser Val Ser Ser Asn Gly Ser Gln Ser Lys Glu Ile         
        15                  20                  25                      

gag gaa atc aag aaa caa gtc cag gtc aac gtt gat gat atc agg gct      145
Glu Glu Ile Lys Lys Gln Val Gln Val Asn Val Asp Asp Ile Arg Ala         
    30                  35                  40                          

gcc aat att aaa ctc gac gga ctt gga aga cag att gct gac atc agc      193
Ala Asn Ile Lys Leu Asp Gly Leu Gly Arg Gln Ile Ala Asp Ile Ser         
45                  50                  55                  60          

aat agc atc tca acc att gag tca aga ttg ggt gag atg gat aat cga      241
Asn Ser Ile Ser Thr Ile Glu Ser Arg Leu Gly Glu Met Asp Asn Arg         
                65                  70                  75              

ctt gtg ggt atc tcg agt cag gtc acg caa tta tct aac tca gtt agc      289
Leu Val Gly Ile Ser Ser Gln Val Thr Gln Leu Ser Asn Ser Val Ser         
            80                  85                  90                  

cag aac act cag agc ata tcc tca ttg ggt gac aga atc aat gct gtc      337
Gln Asn Thr Gln Ser Ile Ser Ser Leu Gly Asp Arg Ile Asn Ala Val         
        95                  100                 105                     

gaa cca cga gtt gac agt ctg gat acg gtc acg tct aat ctc act gga      385
Glu Pro Arg Val Asp Ser Leu Asp Thr Val Thr Ser Asn Leu Thr Gly         
    110                 115                 120                         

cga aca tcc act ttg gag gca gat gtt gga agc tta cgg aca gaa cta      433
Arg Thr Ser Thr Leu Glu Ala Asp Val Gly Ser Leu Arg Thr Glu Leu         
125                 130                 135                 140         

gca gcg cta aca aca cgg gtg aca act gag gtt aca agg tta gat ggt      481
Ala Ala Leu Thr Thr Arg Val Thr Thr Glu Val Thr Arg Leu Asp Gly         
                145                 150                 155             

cta atc aat agt ggc cag aat tcg att ggt gag cta tcc aca aga cta      529
Leu Ile Asn Ser Gly Gln Asn Ser Ile Gly Glu Leu Ser Thr Arg Leu         
            160                 165                 170                 

tcc aat gtg gag acg tct atg gtg acg acg gct gga cgg gga ctg cag      577
Ser Asn Val Glu Thr Ser Met Val Thr Thr Ala Gly Arg Gly Leu Gln         
        175                 180                 185                     

aaa aac gga aac acc ttg aac gtc att gta ggt aat gga atg tgg ttt      625
Lys Asn Gly Asn Thr Leu Asn Val Ile Val Gly Asn Gly Met Trp Phe         
    190                 195                 200                         

aat agt tct aat caa ttg cag ctc gac ctt tcg ggg caa tca aaa ggg      673
Asn Ser Ser Asn Gln Leu Gln Leu Asp Leu Ser Gly Gln Ser Lys Gly         
205                 210                 215                 220         

gtg gga ttt gtc ggc aca gga atg gtg gtt aag att gat act aat tat      721
Val Gly Phe Val Gly Thr Gly Met Val Val Lys Ile Asp Thr Asn Tyr         
                225                 230                 235             

ttt gct tac aat agt aat gga gag att aca ttg gtg agt caa atc aat      769
Phe Ala Tyr Asn Ser Asn Gly Glu Ile Thr Leu Val Ser Gln Ile Asn         
            240                 245                 250                 

gaa ttg cca tcg cgc gta tca aca ctg gaa tca gcg aaa atc gat tca      817
Glu Leu Pro Ser Arg Val Ser Thr Leu Glu Ser Ala Lys Ile Asp Ser         
        255                 260                 265                     

gtt tta cct cca tta acc gta cgc gaa gcg agc ggc gta cgt acc ctg      865
Val Leu Pro Pro Leu Thr Val Arg Glu Ala Ser Gly Val Arg Thr Leu         
    270                 275                 280                         

agc ttt ggt tat gat acg agc gat ttt aca atc atc aac tcc gta ctg      913
Ser Phe Gly Tyr Asp Thr Ser Asp Phe Thr Ile Ile Asn Ser Val Leu         
285                 290                 295                 300         

tcg tta cgg tca cgt ttg act ctt ccg aca tac agg tac cct ctg gag      961
Ser Leu Arg Ser Arg Leu Thr Leu Pro Thr Tyr Arg Tyr Pro Leu Glu         
                305                 310                 315             

ctc gac aca gca aat aat aga gtg cag gtg gca gat cgt ttt ggc atg     1009
Leu Asp Thr Ala Asn Asn Arg Val Gln Val Ala Asp Arg Phe Gly Met         
            320                 325                 330                 

cgc acg ggt act tgg acg gga caa ttg caa tat cag cac cca caa ttg     1057
Arg Thr Gly Thr Trp Thr Gly Gln Leu Gln Tyr Gln His Pro Gln Leu         
        335                 340                 345                     

agt tgg aga gca aat gtc act ttg aat ttg atg aag gtg gat gat tgg     1105
Ser Trp Arg Ala Asn Val Thr Leu Asn Leu Met Lys Val Asp Asp Trp         
    350                 355                 360                         

ttg gtg ttg agc ttt tct cag atg acg act aac tca ata atg gca gat     1153
Leu Val Leu Ser Phe Ser Gln Met Thr Thr Asn Ser Ile Met Ala Asp         
365                 370                 375                 380         

ggg aaa ttt gtg att aat ttt gtg tct ggg tta tct tct gga tgg cag     1201
Gly Lys Phe Val Ile Asn Phe Val Ser Gly Leu Ser Ser Gly Trp Gln         
                385                 390                 395             

acg ggg gat act gaa cca tcg tca act att gat cca tgg tct acg aca     1249
Thr Gly Asp Thr Glu Pro Ser Ser Thr Ile Asp Pro Trp Ser Thr Thr         
            400                 405                 410                 

ttt gcc gcg gtc caa ttt cta aat aac ggt caa cgc att gat gcg ttt     1297
Phe Ala Ala Val Gln Phe Leu Asn Asn Gly Gln Arg Ile Asp Ala Phe         
        415                 420                 425                     

agg atc atg gga gta tcg gaa tgg acg gat gga gaa tta gag att aag     1345
Arg Ile Met Gly Val Ser Glu Trp Thr Asp Gly Glu Leu Glu Ile Lys         
    430                 435                 440                         

aat tat ggt ggc aca tac acc ggt cat act caa gta tat tgg gct ccg     1393
Asn Tyr Gly Gly Thr Tyr Thr Gly His Thr Gln Val Tyr Trp Ala Pro         
445                 450                 455                 460         

tgg acg atc atg tat cca tgc aat gtg agg tga atctagcgcg aaccctcggc   1446
Trp Thr Ile Met Tyr Pro Cys Asn Val Arg                                 
                465                 470                                 

acaaggggtc aatcatc                                                  1463


<210>  2
<211>  470
<212>  PRT
<213>  Mammalian orthoreovirus

<400>  2

Met Asp Ala Ser Leu Ile Thr Glu Ile Arg Lys Ile Val Leu Gln Leu 
1               5                   10                  15      


Ser Val Ser Ser Asn Gly Ser Gln Ser Lys Glu Ile Glu Glu Ile Lys 
            20                  25                  30          


Lys Gln Val Gln Val Asn Val Asp Asp Ile Arg Ala Ala Asn Ile Lys 
        35                  40                  45              


Leu Asp Gly Leu Gly Arg Gln Ile Ala Asp Ile Ser Asn Ser Ile Ser 
    50                  55                  60                  


Thr Ile Glu Ser Arg Leu Gly Glu Met Asp Asn Arg Leu Val Gly Ile 
65                  70                  75                  80  


Ser Ser Gln Val Thr Gln Leu Ser Asn Ser Val Ser Gln Asn Thr Gln 
                85                  90                  95      


Ser Ile Ser Ser Leu Gly Asp Arg Ile Asn Ala Val Glu Pro Arg Val 
            100                 105                 110         


Asp Ser Leu Asp Thr Val Thr Ser Asn Leu Thr Gly Arg Thr Ser Thr 
        115                 120                 125             


Leu Glu Ala Asp Val Gly Ser Leu Arg Thr Glu Leu Ala Ala Leu Thr 
    130                 135                 140                 


Thr Arg Val Thr Thr Glu Val Thr Arg Leu Asp Gly Leu Ile Asn Ser 
145                 150                 155                 160 


Gly Gln Asn Ser Ile Gly Glu Leu Ser Thr Arg Leu Ser Asn Val Glu 
                165                 170                 175     


Thr Ser Met Val Thr Thr Ala Gly Arg Gly Leu Gln Lys Asn Gly Asn 
            180                 185                 190         


Thr Leu Asn Val Ile Val Gly Asn Gly Met Trp Phe Asn Ser Ser Asn 
        195                 200                 205             


Gln Leu Gln Leu Asp Leu Ser Gly Gln Ser Lys Gly Val Gly Phe Val 
    210                 215                 220                 


Gly Thr Gly Met Val Val Lys Ile Asp Thr Asn Tyr Phe Ala Tyr Asn 
225                 230                 235                 240 


Ser Asn Gly Glu Ile Thr Leu Val Ser Gln Ile Asn Glu Leu Pro Ser 
                245                 250                 255     


Arg Val Ser Thr Leu Glu Ser Ala Lys Ile Asp Ser Val Leu Pro Pro 
            260                 265                 270         


Leu Thr Val Arg Glu Ala Ser Gly Val Arg Thr Leu Ser Phe Gly Tyr 
        275                 280                 285             


Asp Thr Ser Asp Phe Thr Ile Ile Asn Ser Val Leu Ser Leu Arg Ser 
    290                 295                 300                 


Arg Leu Thr Leu Pro Thr Tyr Arg Tyr Pro Leu Glu Leu Asp Thr Ala 
305                 310                 315                 320 


Asn Asn Arg Val Gln Val Ala Asp Arg Phe Gly Met Arg Thr Gly Thr 
                325                 330                 335     


Trp Thr Gly Gln Leu Gln Tyr Gln His Pro Gln Leu Ser Trp Arg Ala 
            340                 345                 350         


Asn Val Thr Leu Asn Leu Met Lys Val Asp Asp Trp Leu Val Leu Ser 
        355                 360                 365             


Phe Ser Gln Met Thr Thr Asn Ser Ile Met Ala Asp Gly Lys Phe Val 
    370                 375                 380                 


Ile Asn Phe Val Ser Gly Leu Ser Ser Gly Trp Gln Thr Gly Asp Thr 
385                 390                 395                 400 


Glu Pro Ser Ser Thr Ile Asp Pro Trp Ser Thr Thr Phe Ala Ala Val 
                405                 410                 415     


Gln Phe Leu Asn Asn Gly Gln Arg Ile Asp Ala Phe Arg Ile Met Gly 
            420                 425                 430         


Val Ser Glu Trp Thr Asp Gly Glu Leu Glu Ile Lys Asn Tyr Gly Gly 
        435                 440                 445             


Thr Tyr Thr Gly His Thr Gln Val Tyr Trp Ala Pro Trp Thr Ile Met 
    450                 455                 460                 


Tyr Pro Cys Asn Val Arg 
465                 470 


<210>  3
<211>  1463
<212>  DNA
<213>  Mammalian orthoreovirus


<220>
<221>  CDS
<222>  (14)..(1426)

<400>  3
gctattcgcg cct atg gat gca tct ctc att aca gag ata cgg aaa ata        49
               Met Asp Ala Ser Leu Ile Thr Glu Ile Arg Lys Ile          
               1               5                   10                   

gta ctc caa cta tct gta tca agc aat ggc tcc cag tca aaa gaa atc       97
Val Leu Gln Leu Ser Val Ser Ser Asn Gly Ser Gln Ser Lys Glu Ile         
        15                  20                  25                      

gag gaa atc aag aaa caa gtc cag gtc aac gtt gat gat atc agg gct      145
Glu Glu Ile Lys Lys Gln Val Gln Val Asn Val Asp Asp Ile Arg Ala         
    30                  35                  40                          

gcc aat att aaa ctc gac gga ctt gga aga cag att gct gac atc agc      193
Ala Asn Ile Lys Leu Asp Gly Leu Gly Arg Gln Ile Ala Asp Ile Ser         
45                  50                  55                  60          

aat agc atc tca acc att gag tca aga ttg ggt gag atg gat aat cga      241
Asn Ser Ile Ser Thr Ile Glu Ser Arg Leu Gly Glu Met Asp Asn Arg         
                65                  70                  75              

ctt gtg ggt atc tcg agt cag gtc acg caa tta tct aac tca gtt agc      289
Leu Val Gly Ile Ser Ser Gln Val Thr Gln Leu Ser Asn Ser Val Ser         
            80                  85                  90                  

cag aac act cag agc ata tcc tca ttg ggt gac aga atc aat gct gtc      337
Gln Asn Thr Gln Ser Ile Ser Ser Leu Gly Asp Arg Ile Asn Ala Val         
        95                  100                 105                     

gaa cca cga gtt gac agt ctg gat acg gtc acg tct aat ctc act gga      385
Glu Pro Arg Val Asp Ser Leu Asp Thr Val Thr Ser Asn Leu Thr Gly         
    110                 115                 120                         

cga aca tcc act ttg gag gca gat gtt gga agc tta cgg aca gaa cta      433
Arg Thr Ser Thr Leu Glu Ala Asp Val Gly Ser Leu Arg Thr Glu Leu         
125                 130                 135                 140         

gca gcg cta aca aca cgg gtg aca act gag gtt aca agg tta gat ggt      481
Ala Ala Leu Thr Thr Arg Val Thr Thr Glu Val Thr Arg Leu Asp Gly         
                145                 150                 155             

cta atc aat agt ggc cag aat tcg att ggt gag cta tcc aca aga cta      529
Leu Ile Asn Ser Gly Gln Asn Ser Ile Gly Glu Leu Ser Thr Arg Leu         
            160                 165                 170                 

tcc aat gtg gag acg tct atg gtg acg acg gct gga cgg gga ctg cag      577
Ser Asn Val Glu Thr Ser Met Val Thr Thr Ala Gly Arg Gly Leu Gln         
        175                 180                 185                     

aaa aac gga aac acc ttg aac gtc att gta ggt aat gga atg tgg ttt      625
Lys Asn Gly Asn Thr Leu Asn Val Ile Val Gly Asn Gly Met Trp Phe         
    190                 195                 200                         

aat agt tct aat caa ttg cag ctc gac ctt tcg ggg caa tca aaa ggg      673
Asn Ser Ser Asn Gln Leu Gln Leu Asp Leu Ser Gly Gln Ser Lys Gly         
205                 210                 215                 220         

gtg gga ttt gtc ggc aca gga atg gtg gtt aag att gat act aat tat      721
Val Gly Phe Val Gly Thr Gly Met Val Val Lys Ile Asp Thr Asn Tyr         
                225                 230                 235             

ttt gct tac aat agt aat gga gag att aca ttg gtg agt caa atc aat      769
Phe Ala Tyr Asn Ser Asn Gly Glu Ile Thr Leu Val Ser Gln Ile Asn         
            240                 245                 250                 

gaa ttg cca tcg cgc gta tca aca ctg gaa tca gcg aaa atc gat tca      817
Glu Leu Pro Ser Arg Val Ser Thr Leu Glu Ser Ala Lys Ile Asp Ser         
        255                 260                 265                     

gtt tta cct cca tta acc gta cgc gaa gcg agc ggc gta cgt acc ctg      865
Val Leu Pro Pro Leu Thr Val Arg Glu Ala Ser Gly Val Arg Thr Leu         
    270                 275                 280                         

agc ttt ggt tat gat acg agc gat ttt aca atc atc aac tcc gta ctg      913
Ser Phe Gly Tyr Asp Thr Ser Asp Phe Thr Ile Ile Asn Ser Val Leu         
285                 290                 295                 300         

tcg tta cgg tca cgt ttg act ctt ccg aca tac agg tac cct ctg gag      961
Ser Leu Arg Ser Arg Leu Thr Leu Pro Thr Tyr Arg Tyr Pro Leu Glu         
                305                 310                 315             

ctc gac aca gca aat aat aga gtg cag gtg gca gat cgt ttt ggc atg     1009
Leu Asp Thr Ala Asn Asn Arg Val Gln Val Ala Asp Arg Phe Gly Met         
            320                 325                 330                 

cgc acg ggt act tgg acg gga caa ttg caa tat cag cac cca caa ttg     1057
Arg Thr Gly Thr Trp Thr Gly Gln Leu Gln Tyr Gln His Pro Gln Leu         
        335                 340                 345                     

agt tgg aga gca aat gtc act ttg aat ttg atg aag gtg gat gat tgg     1105
Ser Trp Arg Ala Asn Val Thr Leu Asn Leu Met Lys Val Asp Asp Trp         
    350                 355                 360                         

ttg gtg ttg agc ttt tct cag atg acg act aac tca ata atg gca gat     1153
Leu Val Leu Ser Phe Ser Gln Met Thr Thr Asn Ser Ile Met Ala Asp         
365                 370                 375                 380         

ggg aaa ttt gtg att aat ttt gtg tct ggg tta tct tct gga tgg cag     1201
Gly Lys Phe Val Ile Asn Phe Val Ser Gly Leu Ser Ser Gly Trp Gln         
                385                 390                 395             

acg ggg gat act gaa cca tcg tca act att gat cca tgg tct acg aca     1249
Thr Gly Asp Thr Glu Pro Ser Ser Thr Ile Asp Pro Trp Ser Thr Thr         
            400                 405                 410                 

ttt gcc gcg gtc caa ttt cta aat aac ggt caa cgc att gat gcg ttt     1297
Phe Ala Ala Val Gln Phe Leu Asn Asn Gly Gln Arg Ile Asp Ala Phe         
        415                 420                 425                     

agg atc atg gga gta tcg gaa tgg acg gat gga gaa tta gag att aag     1345
Arg Ile Met Gly Val Ser Glu Trp Thr Asp Gly Glu Leu Glu Ile Lys         
    430                 435                 440                         

aat tat ggt ggc aca tac acc ggt cat act caa gta tat tgg gct ccg     1393
Asn Tyr Gly Gly Thr Tyr Thr Gly His Thr Gln Val Tyr Trp Ala Pro         
445                 450                 455                 460         

tgg acg atc atg tat cca tgc aat gtg agg tga atctagcgcg aaccctcggc   1446
Trp Thr Ile Met Tyr Pro Cys Asn Val Arg                                 
                465                 470                                 

acaaggggtc aatcatc                                                  1463


<210>  4
<211>  470
<212>  PRT
<213>  Mammalian orthoreovirus

<400>  4

Met Asp Ala Ser Leu Ile Thr Glu Ile Arg Lys Ile Val Leu Gln Leu 
1               5                   10                  15      


Ser Val Ser Ser Asn Gly Ser Gln Ser Lys Glu Ile Glu Glu Ile Lys 
            20                  25                  30          


Lys Gln Val Gln Val Asn Val Asp Asp Ile Arg Ala Ala Asn Ile Lys 
        35                  40                  45              


Leu Asp Gly Leu Gly Arg Gln Ile Ala Asp Ile Ser Asn Ser Ile Ser 
    50                  55                  60                  


Thr Ile Glu Ser Arg Leu Gly Glu Met Asp Asn Arg Leu Val Gly Ile 
65                  70                  75                  80  


Ser Ser Gln Val Thr Gln Leu Ser Asn Ser Val Ser Gln Asn Thr Gln 
                85                  90                  95      


Ser Ile Ser Ser Leu Gly Asp Arg Ile Asn Ala Val Glu Pro Arg Val 
            100                 105                 110         


Asp Ser Leu Asp Thr Val Thr Ser Asn Leu Thr Gly Arg Thr Ser Thr 
        115                 120                 125             


Leu Glu Ala Asp Val Gly Ser Leu Arg Thr Glu Leu Ala Ala Leu Thr 
    130                 135                 140                 


Thr Arg Val Thr Thr Glu Val Thr Arg Leu Asp Gly Leu Ile Asn Ser 
145                 150                 155                 160 


Gly Gln Asn Ser Ile Gly Glu Leu Ser Thr Arg Leu Ser Asn Val Glu 
                165                 170                 175     


Thr Ser Met Val Thr Thr Ala Gly Arg Gly Leu Gln Lys Asn Gly Asn 
            180                 185                 190         


Thr Leu Asn Val Ile Val Gly Asn Gly Met Trp Phe Asn Ser Ser Asn 
        195                 200                 205             


Gln Leu Gln Leu Asp Leu Ser Gly Gln Ser Lys Gly Val Gly Phe Val 
    210                 215                 220                 


Gly Thr Gly Met Val Val Lys Ile Asp Thr Asn Tyr Phe Ala Tyr Asn 
225                 230                 235                 240 


Ser Asn Gly Glu Ile Thr Leu Val Ser Gln Ile Asn Glu Leu Pro Ser 
                245                 250                 255     


Arg Val Ser Thr Leu Glu Ser Ala Lys Ile Asp Ser Val Leu Pro Pro 
            260                 265                 270         


Leu Thr Val Arg Glu Ala Ser Gly Val Arg Thr Leu Ser Phe Gly Tyr 
        275                 280                 285             


Asp Thr Ser Asp Phe Thr Ile Ile Asn Ser Val Leu Ser Leu Arg Ser 
    290                 295                 300                 


Arg Leu Thr Leu Pro Thr Tyr Arg Tyr Pro Leu Glu Leu Asp Thr Ala 
305                 310                 315                 320 


Asn Asn Arg Val Gln Val Ala Asp Arg Phe Gly Met Arg Thr Gly Thr 
                325                 330                 335     


Trp Thr Gly Gln Leu Gln Tyr Gln His Pro Gln Leu Ser Trp Arg Ala 
            340                 345                 350         


Asn Val Thr Leu Asn Leu Met Lys Val Asp Asp Trp Leu Val Leu Ser 
        355                 360                 365             


Phe Ser Gln Met Thr Thr Asn Ser Ile Met Ala Asp Gly Lys Phe Val 
    370                 375                 380                 


Ile Asn Phe Val Ser Gly Leu Ser Ser Gly Trp Gln Thr Gly Asp Thr 
385                 390                 395                 400 


Glu Pro Ser Ser Thr Ile Asp Pro Trp Ser Thr Thr Phe Ala Ala Val 
                405                 410                 415     


Gln Phe Leu Asn Asn Gly Gln Arg Ile Asp Ala Phe Arg Ile Met Gly 
            420                 425                 430         


Val Ser Glu Trp Thr Asp Gly Glu Leu Glu Ile Lys Asn Tyr Gly Gly 
        435                 440                 445             


Thr Tyr Thr Gly His Thr Gln Val Tyr Trp Ala Pro Trp Thr Ile Met 
    450                 455                 460                 


Tyr Pro Cys Asn Val Arg 
465                 470 


<210>  5
<211>  1416
<212>  DNA
<213>  Mammalian orthoreovirus


<220>
<221>  CDS
<222>  (71)..(433)

<400>  5
gctattggtc ggatggatcc tcgcctacgt gaagaagtag tacggctgat aatcgcatta     60

acgagtgata atg gag cat cac tgt caa aag ggc ttg aat caa ggg tct       109
           Met Glu His His Cys Gln Lys Gly Leu Asn Gln Gly Ser          
           1               5                   10                       

cgg cgc tcg aga aga cgt ctc aaa tac act ctg ata cta tcc tcc gga      157
Arg Arg Ser Arg Arg Arg Leu Lys Tyr Thr Leu Ile Leu Ser Ser Gly         
    15                  20                  25                          

tca ccc agg gac tcg atg atg caa aca aac gaa tca tcg ctc ttg agc      205
Ser Pro Arg Asp Ser Met Met Gln Thr Asn Glu Ser Ser Leu Leu Ser         
30                  35                  40                  45          

aaa gtc ggg atg act tgg ttg cat cag tca gtg atg ctc aac ttg caa      253
Lys Val Gly Met Thr Trp Leu His Gln Ser Val Met Leu Asn Leu Gln         
                50                  55                  60              

tct cca gat tgg aaa gct cta tcg gag ccc tcc aaa cag ttg tca atg      301
Ser Pro Asp Trp Lys Ala Leu Ser Glu Pro Ser Lys Gln Leu Ser Met         
            65                  70                  75                  

gac ttg att cga gtg tta ccc agt tgg gtg ctc gag tgg gac aac ttg      349
Asp Leu Ile Arg Val Leu Pro Ser Trp Val Leu Glu Trp Asp Asn Leu         
        80                  85                  90                      

aga cag gac ttg cag acg tac gcg ttg atc acg aca atc tcg ttg cga      397
Arg Gln Asp Leu Gln Thr Tyr Ala Leu Ile Thr Thr Ile Ser Leu Arg         
    95                  100                 105                         

gag tgg ata ctg cag aac gta aca ttg gat cat tga ccactgagct           443
Glu Trp Ile Leu Gln Asn Val Thr Leu Asp His                             
110                 115                 120                             

atcaactctg acgttacgag taacatccat acaagcggat ttcgaatcta ggatatccac    503

gttagagcgc acggcggtca ctagcgcggg agctcccctc tcaatccgta ataaccgtat    563

gaccatggga ttaaatgatg gactcacgtt gtcagggaat aatctcgcca tccgattgcc    623

aggaaatacg ggtctgaata ttcaaaatgg tggacttcag tttcgattta atactgatca    683

attccagata gttaataata acttgactct caagacgact gtgtttgatt ctatcaactc    743

aaggataggc gcaactgagc aaagttacgt ggcgtcggca gtgactccct tgagattaaa    803

cagtagcacg aaggtgctgg atatgctaat agacagttca acacttgaaa ttaattctag    863

tggacagcta actgttagat cgacatcccc gaatttgagg tatccgatag ctgatgttag    923

cggcggtatc ggaatgagtc caaattatag gtttaggcag agcatgtgga taggaattgt    983

ctcctattct ggtagtgggc tgaattggag ggtacaggtg aactccgaca tttttattgt   1043

agatgattac atacatatat gtcttccagc ttttgacggt ttctctatag ctgacggtgg   1103

agatctatcg ttgaactttg ttaccggatt gttaccaccg ttacttacag gagacactga   1163

gcccgctttt cataatgacg tggtcacata tggagcacag actgtagcta tagggttgtc   1223

gtcgggtggt gcgcctcagt atatgagtaa gaatctgtgg gtggagcagt ggcaggatgg   1283

agtacttcgg ttacgtgttg aggggggtgg ctcaattacg cactcaaaca gtaagtggcc   1343

tgccatgacc gtttcgtacc cgcgtagttt cacgtgagga tcagaccacc ccgcggcact   1403

ggggcatttc atc                                                      1416


<210>  6
<211>  120
<212>  PRT
<213>  Mammalian orthoreovirus

<400>  6

Met Glu His His Cys Gln Lys Gly Leu Asn Gln Gly Ser Arg Arg Ser 
1               5                   10                  15      


Arg Arg Arg Leu Lys Tyr Thr Leu Ile Leu Ser Ser Gly Ser Pro Arg 
            20                  25                  30          


Asp Ser Met Met Gln Thr Asn Glu Ser Ser Leu Leu Ser Lys Val Gly 
        35                  40                  45              


Met Thr Trp Leu His Gln Ser Val Met Leu Asn Leu Gln Ser Pro Asp 
    50                  55                  60                  


Trp Lys Ala Leu Ser Glu Pro Ser Lys Gln Leu Ser Met Asp Leu Ile 
65                  70                  75                  80  


Arg Val Leu Pro Ser Trp Val Leu Glu Trp Asp Asn Leu Arg Gln Asp 
                85                  90                  95      


Leu Gln Thr Tyr Ala Leu Ile Thr Thr Ile Ser Leu Arg Glu Trp Ile 
            100                 105                 110         


Leu Gln Asn Val Thr Leu Asp His 
        115                 120 


<210>  7
<211>  1368
<212>  DNA
<213>  Reovirus sp.


<220>
<221>  CDS
<222>  (1)..(1368)

<400>  7
atg gat cct cgc cta cgt gaa gaa gta gta cgg ctg att atc gca tta       48
Met Asp Pro Arg Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu         
1               5                   10                  15              

acg agt gat aat gga ata tca ctg tca aaa ggg ctt gaa tca agg gtc       96
Thr Ser Asp Asn Gly Ile Ser Leu Ser Lys Gly Leu Glu Ser Arg Val         
            20                  25                  30                  

tcg gcg ctc gag aag acg tct caa ata cac tct gat act atc ctc cgg      144
Ser Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg         
        35                  40                  45                      

atc acc cag gga ctc gat gat gca aac aaa cga atc atc gct ctt gag      192
Ile Thr Gln Gly Leu Asp Asp Ala Asn Lys Arg Ile Ile Ala Leu Glu         
    50                  55                  60                          

caa agt cgg gat gac ttg gtt gca tca gtc agt gat gct caa ctt gca      240
Gln Ser Arg Asp Asp Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala         
65                  70                  75                  80          

atc tcc aga ttg gaa agc tct acc gga gcc ctc caa aca gtt gtc aat      288
Ile Ser Arg Leu Glu Ser Ser Thr Gly Ala Leu Gln Thr Val Val Asn         
                85                  90                  95              

gga ctt gat tcg agt gtt acc cag ttg ggt gct cga gtg gga caa ctt      336
Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Ala Arg Val Gly Gln Leu         
            100                 105                 110                 

gag aca gga ctt gca gag cta cgc gtt gat cac gac aat ctc gtt gcg      384
Glu Thr Gly Leu Ala Glu Leu Arg Val Asp His Asp Asn Leu Val Ala         
        115                 120                 125                     

aga gtg gat act gcg gaa cgt aac att gga tca ttg acc act gag cta      432
Arg Val Asp Thr Ala Glu Arg Asn Ile Gly Ser Leu Thr Thr Glu Leu         
    130                 135                 140                         

tca act ctg acg tta cga gta aca tct ata caa gcg gat ttc gaa tct      480
Ser Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ala Asp Phe Glu Ser         
145                 150                 155                 160         

agg ata tcc aca tta gag cgc acg gcg gtc act agc gct gga gct ccc      528
Arg Ile Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Gly Ala Pro         
                165                 170                 175             

ctc tca atc cgt aat aac cgt atg acc atg gga tta aat gat gga ctt      576
Leu Ser Ile Arg Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu         
            180                 185                 190                 

acg ttg tca ggg aat aat ctc gcc att cgg ttg cca ggc aat acg ggt      624
Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly         
        195                 200                 205                     

ctg aat att caa aat ggt gga ctt cag ttt cga ttt aat act gat cag      672
Leu Asn Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asp Gln         
    210                 215                 220                         

ttc cag ata gtt aat aat aac ttg act ctc aag acg act gtg ttt gat      720
Phe Gln Ile Val Asn Asn Asn Leu Thr Leu Lys Thr Thr Val Phe Asp         
225                 230                 235                 240         

tct atc aac tca ggg ata ggc gca att gag caa agt tac gtg gcg tca      768
Ser Ile Asn Ser Gly Ile Gly Ala Ile Glu Gln Ser Tyr Val Ala Ser         
                245                 250                 255             

gca gtg act ccc ttg aga tta aac agt agc acg aag gtg ttg gat atg      816
Ala Val Thr Pro Leu Arg Leu Asn Ser Ser Thr Lys Val Leu Asp Met         
            260                 265                 270                 

cta ata gac agt tca aca ctt gaa att aat tct agt gga cag cta act      864
Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ser Ser Gly Gln Leu Thr         
        275                 280                 285                     

gtt aga tcg aca tcc ccg aat ttg agg tat ccg ata gct gat gtt agc      912
Val Arg Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Val Ser         
    290                 295                 300                         

ggc ggt att gga atg agt cca aat tat agg ttt agg cag agc atg tgg      960
Gly Gly Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Gln Ser Met Trp         
305                 310                 315                 320         

ata gga att gtc tcc tat tct ggc agt ggg ctg aat tgg agg gta cag     1008
Ile Gly Ile Val Ser Tyr Ser Gly Ser Gly Leu Asn Trp Arg Val Gln         
                325                 330                 335             

gtg aac tcc gac att ttt att gta gat gat tac ata cat ata tgt ctt     1056
Val Asn Ser Asp Ile Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu         
            340                 345                 350                 

cca gct ttt aac ggt ttc tct ata gct gac ggt gga gat cta tcg ttg     1104
Pro Ala Phe Asn Gly Phe Ser Ile Ala Asp Gly Gly Asp Leu Ser Leu         
        355                 360                 365                     

aac ttt gtt acc gga tta tta cca ccg tta ctt acc gga gac act gag     1152
Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu         
    370                 375                 380                         

ccc gct ttt cat aat gac gtg gtc aca tat gga gca cag act gta gct     1200
Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Gln Thr Val Ala         
385                 390                 395                 400         

ata ggg ttg tcg tcg ggt ggt gcg cct cag tat atg agc aag aat ctg     1248
Ile Gly Leu Ser Ser Gly Gly Ala Pro Gln Tyr Met Ser Lys Asn Leu         
                405                 410                 415             

tgg gtg gag cag tgg cag gat gga gta ctt cgg tta cgt gtt gag ggg     1296
Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly         
            420                 425                 430                 

ggt ggc tca att acg cac tca aac agt aag tgg cct gcc atg acc gtt     1344
Gly Gly Ser Ile Thr His Ser Asn Ser Lys Trp Pro Ala Met Thr Val         
        435                 440                 445                     

tcg tac ccg cgt agt ttc acg tga                                     1368
Ser Tyr Pro Arg Ser Phe Thr                                             
    450                 455                                             


<210>  8
<211>  455
<212>  PRT
<213>  Reovirus sp.

<400>  8

Met Asp Pro Arg Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu 
1               5                   10                  15      


Thr Ser Asp Asn Gly Ile Ser Leu Ser Lys Gly Leu Glu Ser Arg Val 
            20                  25                  30          


Ser Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg 
        35                  40                  45              


Ile Thr Gln Gly Leu Asp Asp Ala Asn Lys Arg Ile Ile Ala Leu Glu 
    50                  55                  60                  


Gln Ser Arg Asp Asp Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Ser Ser Thr Gly Ala Leu Gln Thr Val Val Asn 
                85                  90                  95      


Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Ala Arg Val Gly Gln Leu 
            100                 105                 110         


Glu Thr Gly Leu Ala Glu Leu Arg Val Asp His Asp Asn Leu Val Ala 
        115                 120                 125             


Arg Val Asp Thr Ala Glu Arg Asn Ile Gly Ser Leu Thr Thr Glu Leu 
    130                 135                 140                 


Ser Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ala Asp Phe Glu Ser 
145                 150                 155                 160 


Arg Ile Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Gly Ala Pro 
                165                 170                 175     


Leu Ser Ile Arg Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu 
            180                 185                 190         


Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly 
        195                 200                 205             


Leu Asn Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asp Gln 
    210                 215                 220                 


Phe Gln Ile Val Asn Asn Asn Leu Thr Leu Lys Thr Thr Val Phe Asp 
225                 230                 235                 240 


Ser Ile Asn Ser Gly Ile Gly Ala Ile Glu Gln Ser Tyr Val Ala Ser 
                245                 250                 255     


Ala Val Thr Pro Leu Arg Leu Asn Ser Ser Thr Lys Val Leu Asp Met 
            260                 265                 270         


Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ser Ser Gly Gln Leu Thr 
        275                 280                 285             


Val Arg Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Val Ser 
    290                 295                 300                 


Gly Gly Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Gln Ser Met Trp 
305                 310                 315                 320 


Ile Gly Ile Val Ser Tyr Ser Gly Ser Gly Leu Asn Trp Arg Val Gln 
                325                 330                 335     


Val Asn Ser Asp Ile Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu 
            340                 345                 350         


Pro Ala Phe Asn Gly Phe Ser Ile Ala Asp Gly Gly Asp Leu Ser Leu 
        355                 360                 365             


Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu 
    370                 375                 380                 


Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Gln Thr Val Ala 
385                 390                 395                 400 


Ile Gly Leu Ser Ser Gly Gly Ala Pro Gln Tyr Met Ser Lys Asn Leu 
                405                 410                 415     


Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly 
            420                 425                 430         


Gly Gly Ser Ile Thr His Ser Asn Ser Lys Trp Pro Ala Met Thr Val 
        435                 440                 445             


Ser Tyr Pro Arg Ser Phe Thr 
    450                 455 


