                         SEQUENCE LISTING

<110>  Ghim, Shin-je
       Jenson, A. Bennett
       Lasnik, Amanda B.
       Miller, Donald M.
       Palmer, Kenneth
       Smith, Mark L
 
<120>  PLANT-PRODUCED COMPOSITIONS FOR TREATING PAPILLOMAVIRUS INFECTION
        AND RELATED METHODS

<130>  UN024/0UN64

<150>  60/888,873
<151>  2007-02-08

<150>  11/950,366
<151>  2007-12-04

<150>  11/107,575
<151>  2005-04-15

<150>  60/563,071
<151>  2004-04-15

<150>  11/518,549
<151>  2006-09-08

<150>  60/715,703
<151>  2005-09-08

<160>  16    

<170>  PatentIn version 3.4

<210>  1
<211>  473
<212>  PRT
<213>  Human papillomavirus type 16

<400>  1

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro 
        115                 120                 125             


Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala 
    130                 135                 140                 


Ile Leu Asp Ile Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn 
145                 150                 155                 160 


Pro Thr Phe Thr Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu 
                165                 170                 175     


Thr Gly Gly His Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn 
            180                 185                 190         


Tyr Glu Glu Ile Pro Met Asp Thr Phe Ile Val Ser Thr Asn Pro Asn 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Pro Ile Pro Gly Ser Arg Pro Val Ala Arg 
    210                 215                 220                 


Leu Gly Leu Tyr Ser Arg Thr Thr Gln Gln Val Lys Val Val Asp Pro 
225                 230                 235                 240 


Ala Phe Val Thr Thr Pro Thr Lys Leu Ile Thr Tyr Asp Asn Pro Ala 
                245                 250                 255     


Tyr Glu Gly Ile Asp Val Asp Asn Thr Leu Tyr Phe Ser Ser Asn Asp 
            260                 265                 270         


Asn Ser Ile Asn Ile Ala Pro Asp Pro Asp Phe Leu Asp Ile Val Ala 
        275                 280                 285             


Leu His Arg Pro Ala Leu Thr Ser Arg Arg Thr Gly Ile Arg Tyr Ser 
    290                 295                 300                 


Arg Ile Gly Asn Lys Gln Thr Leu Arg Thr Arg Ser Gly Lys Ser Ile 
305                 310                 315                 320 


Gly Ala Lys Val His Tyr Tyr Tyr Asp Leu Ser Thr Ile Asp Pro Ala 
                325                 330                 335     


Glu Glu Ile Glu Leu Gln Thr Ile Thr Pro Ser Thr Tyr Thr Thr Thr 
            340                 345                 350         


Ser His Ala Ala Ser Pro Thr Ser Ile Asn Asn Gly Leu Tyr Asp Ile 
        355                 360                 365             


Tyr Ala Asp Asp Phe Ile Thr Asp Thr Ser Thr Thr Pro Val Pro Ser 
    370                 375                 380                 


Val Pro Ser Thr Ser Leu Ser Gly Tyr Ile Pro Ala Asn Thr Thr Ile 
385                 390                 395                 400 


Pro Phe Gly Gly Ala Tyr Asn Ile Pro Leu Val Ser Gly Pro Asp Ile 
                405                 410                 415     


Pro Ile Asn Ile Thr Asp Gln Ala Pro Ser Leu Ile Pro Ile Val Pro 
            420                 425                 430         


Gly Ser Pro Gln Tyr Thr Ile Ile Ala Asp Ala Gly Asp Phe Tyr Leu 
        435                 440                 445             


His Pro Ser Tyr Tyr Met Leu Arg Lys Arg Arg Lys Arg Leu Pro Tyr 
    450                 455                 460                 


Phe Phe Ser Asp Val Ser Leu Ala Ala 
465                 470             


<210>  2
<211>  174
<212>  PRT
<213>  Canine oral papillomavirus

<400>  2

Met Ala Leu Ile Arg Lys Arg Arg Ala Ala Pro Gln Asp Ile Tyr Pro 
1               5                   10                  15      


Ala Cys Lys Val Ser Asn Thr Cys Pro Ala Asp Ile Leu Asn Lys Met 
            20                  25                  30          


Glu Gln Asn Thr Leu Ala Asp Lys Ile Leu Lys Tyr Gly Ser Ala Gly 
        35                  40                  45              


Val Phe Leu Gly Gly Leu Gly Ile Ser Thr Gly Lys Gly Val Gly Gly 
    50                  55                  60                  


Arg Thr Gly Tyr Ile Pro Leu Gly Gly Thr Glu Ser Gly Val Gly Val 
65                  70                  75                  80  


Gly Thr Arg Val Thr Thr Ile Arg Pro Thr Val Pro Ile Ser Ser Val 
                85                  90                  95      


Gly Ser Pro Asp Phe Ile Pro Val Asp Ala Val Asp Pro Leu Gly Pro 
            100                 105                 110         


Ala Val Ile Pro Pro Glu Arg Phe Pro Ile Ala Val Glu Asp Pro Phe 
        115                 120                 125             


Thr Leu Pro Pro Pro Arg Phe Pro Thr Ala Val Glu Glu Asp Val Ile 
    130                 135                 140                 


Glu Leu Gln Pro Ile Pro Gly Pro Ser Ser Glu Ile Pro Leu Ala Gly 
145                 150                 155                 160 


Pro Lys Ile Thr Thr Asp Ala Gln Pro Ala Ile Leu Glu Val 
                165                 170                 


<210>  3
<211>  120
<212>  PRT
<213>  Human papillomavirus type 6

<400>  3

Met Ala His Ser Arg Ala Arg Arg Arg Lys Arg Ala Ser Ala Thr Gln 
1               5                   10                  15      


Leu Tyr Gln Thr Cys Lys Leu Thr Gly Thr Cys Pro Pro Asp Val Ile 
            20                  25                  30          


Pro Lys Val Glu His Asn Thr Ile Ala Asp Gln Ile Leu Lys Trp Gly 
        35                  40                  45              


Ser Leu Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly 
    50                  55                  60                  


Thr Gly Gly Arg Thr Gly Tyr Val Pro Leu Gly Thr Ser Ala Lys Pro 
65                  70                  75                  80  


Ser Ile Thr Ser Gly Pro Met Ala Arg Pro Pro Val Val Val Glu Pro 
                85                  90                  95      


Val Ala Pro Ser Asp Pro Ser Ile Val Ser Leu Ile Glu Glu Ser Ala 
            100                 105                 110         


Ile Ile Asn Ala Gly Ala Pro Glu 
        115                 120 


<210>  4
<211>  120
<212>  PRT
<213>  Human papillomavirus type 11

<400>  4

Met Lys Pro Arg Ala Arg Arg Arg Lys Arg Ala Ser Ala Thr Gln Leu 
1               5                   10                  15      


Tyr Gln Thr Cys Lys Ala Thr Gly Thr Cys Pro Pro Asp Val Ile Pro 
            20                  25                  30          


Lys Val Glu His Thr Thr Ile Ala Asp Gln Ile Leu Lys Trp Gly Ser 
        35                  40                  45              


Leu Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ala Gly Ser 
    50                  55                  60                  


Gly Gly Arg Ala Gly Tyr Ile Pro Leu Gly Ser Ser Pro Lys Pro Ala 
65                  70                  75                  80  


Ile Thr Gly Gly Pro Ala Ala Arg Pro Pro Val Leu Val Glu Pro Val 
                85                  90                  95      


Ala Pro Ser Asp Pro Ser Ile Val Ser Leu Ile Glu Glu Ser Ala Ile 
            100                 105                 110         


Ile Asn Ala Gly Ala Pro Glu Val 
        115                 120 


<210>  5
<211>  120
<212>  PRT
<213>  Human papillomavirus type 16

<400>  5

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro 
        115                 120 


<210>  6
<211>  120
<212>  PRT
<213>  Human papillomavirus type 18

<400>  6

Met Val Ser His Arg Ala Ala Arg Arg Lys Arg Ala Ser Val Thr Asp 
1               5                   10                  15      


Leu Tyr Lys Thr Cys Lys Gln Ser Gly Thr Cys Pro Pro Asp Val Val 
            20                  25                  30          


Pro Lys Val Glu Gly Thr Thr Leu Ala Asp Lys Ile Leu Gln Trp Ser 
        35                  40                  45              


Ser Leu Gly Ile Phe Leu Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly 
    50                  55                  60                  


Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Gly Arg Ser Asn Thr 
65                  70                  75                  80  


Val Val Asp Val Gly Pro Thr Arg Pro Pro Val Val Ile Glu Pro Val 
                85                  90                  95      


Gly Pro Thr Asp Pro Ser Ile Val Thr Leu Ile Glu Asp Ser Ser Val 
            100                 105                 110         


Val Thr Ser Gly Ala Pro Arg Pro 
        115                 120 


<210>  7
<211>  120
<212>  PRT
<213>  Human papillomavirus type 26

<400>  7

Met Val Ala Val Arg Ala Pro Arg Arg Lys Arg Ala Ser Ala Thr Asp 
1               5                   10                  15      


Leu Tyr Lys Thr Cys Lys Ala Ala Gly Thr Cys Pro Pro Asp Val Ile 
            20                  25                  30          


Pro Lys Ile Glu Gly Ser Thr Leu Ala Asp Lys Ile Leu Gln Trp Ser 
        35                  40                  45              


Gly Leu Gly Ile Phe Leu Gly Gly Leu Gly Ile Gly Thr Gly Thr Gly 
    50                  55                  60                  


Ser Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Gly Gly Gly Arg Pro 
65                  70                  75                  80  


Ser Val Val Asp Ile Gly Pro Thr Arg Pro Pro Ile Ile Ile Glu Pro 
                85                  90                  95      


Val Gly Pro Thr Glu Pro Ser Ile Val Thr Leu Val Glu Glu Ser Ser 
            100                 105                 110         


Ile Ile Gln Ser Gly Ala Pro Ile 
        115                 120 


<210>  8
<211>  120
<212>  PRT
<213>  Human papillomavirus type 31

<400>  8

Met Arg Ser Lys Arg Ser Thr Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Gln Thr Cys Lys Ala Ala Gly Thr Cys Pro Ser Asp Val 
            20                  25                  30          


Ile Pro Lys Ile Glu His Thr Thr Ile Ala Asp Gln Ile Leu Arg Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Val Pro Leu Ser Thr Arg Pro Ser 
65                  70                  75                  80  


Thr Val Ser Glu Ala Ser Ile Pro Ile Arg Pro Pro Val Ser Ile Asp 
                85                  90                  95      


Pro Val Gly Pro Leu Asp Pro Ser Ile Val Ser Leu Val Glu Glu Ser 
            100                 105                 110         


Gly Ile Val Asp Val Gly Ala Pro 
        115                 120 


<210>  9
<211>  120
<212>  PRT
<213>  Human papillomavirus type 35

<400>  9

Met Arg His Lys Arg Ser Thr Lys Arg Val Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Arg Thr Cys Lys Ala Ala Gly Thr Cys Pro Pro Asp Val 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Asn Thr Val Ala Asp Gln Ile Leu Lys Tyr 
        35                  40                  45              


Gly Ser Met Ala Val Phe Phe Gly Gly Leu Gly Ile Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Ser Gly Tyr Val Pro Leu Gly Thr Thr Pro Pro 
65                  70                  75                  80  


Thr Ala Ala Thr Asn Ile Pro Ile Arg Pro Pro Val Thr Val Glu Ser 
                85                  90                  95      


Ile Pro Leu Asp Thr Ile Gly Pro Leu Asp Ser Ser Ile Val Ser Leu 
            100                 105                 110         


Val Glu Glu Thr Ser Phe Ile Glu 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  Human papillomavirus type 40

<400>  10

Met Val Ser Ser Arg Pro Arg Arg Arg Lys Arg Ala Ser Ala Thr Gln 
1               5                   10                  15      


Leu Tyr Gln Thr Cys Lys Ala Ala Gly Thr Cys Pro Pro Asp Val Val 
            20                  25                  30          


His Lys Val Glu Gln Thr Thr Val Ala Asp Gln Ile Leu Lys Trp Gly 
        35                  40                  45              


Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Ser Gly Ser Gly 
    50                  55                  60                  


Thr Gly Gly Arg Ala Gly Tyr Val Pro Leu Ser Thr Gly Ser Arg Ala 
65                  70                  75                  80  


Val Pro Pro Lys Ser Leu Val Pro Asp Val Val Ala Arg Pro Pro Val 
                85                  90                  95      


Val Val Asp Thr Val Ala Pro Ser Asp Pro Ser Ile Val Ser Leu Ile 
            100                 105                 110         


Glu Glu Ser Ser Ile Ile Gln Ser 
        115                 120 


<210>  11
<211>  120
<212>  PRT
<213>  Human papillomavirus type 45

<400>  11

Met Val Ser His Arg Ala Ala Arg Arg Lys Arg Ala Ser Ala Thr Asp 
1               5                   10                  15      


Leu Tyr Arg Thr Cys Lys Gln Ser Gly Thr Cys Pro Pro Asp Val Ile 
            20                  25                  30          


Asn Lys Val Glu Gly Thr Thr Leu Ala Asp Lys Ile Leu Gln Trp Ser 
        35                  40                  45              


Ser Leu Gly Ile Phe Leu Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly 
    50                  55                  60                  


Ser Gly Gly Arg Thr Gly Tyr Val Pro Leu Gly Gly Arg Ser Asn Thr 
65                  70                  75                  80  


Val Val Asp Val Gly Pro Thr Arg Pro Pro Val Val Ile Glu Pro Val 
                85                  90                  95      


Gly Pro Thr Asp Pro Ser Ile Val Thr Leu Val Glu Asp Ser Ser Val 
            100                 105                 110         


Val Ala Ser Gly Ala Pro Val Pro 
        115                 120 


<210>  12
<211>  120
<212>  PRT
<213>  Human papillomavirus type 53

<400>  12

Met Val Ala His Arg Ala Arg Arg Arg Lys Arg Ala Ser Ala Thr Gln 
1               5                   10                  15      


Leu Tyr Gln Thr Cys Lys Gln Ser Gly Thr Cys Pro Glu Asp Val Ile 
            20                  25                  30          


Asn Lys Ile Glu His Lys Thr Trp Ala Asp Lys Ile Leu Gln Trp Gly 
        35                  40                  45              


Ser Leu Phe Thr Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly 
    50                  55                  60                  


Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Ser Thr 
65                  70                  75                  80  


Val Val Asp Val Thr Pro Ala Arg Pro Pro Ile Val Val Glu Ser Val 
                85                  90                  95      


Gly Pro Thr Asp Pro Ser Ile Val Thr Leu Val Glu Glu Ser Ser Val 
            100                 105                 110         


Ile Glu Ser Gly Ala Ser Phe Pro 
        115                 120 


<210>  13
<211>  120
<212>  PRT
<213>  Human papillomavirus type 58

<400>  13

Met Arg His Lys Arg Ser Thr Arg Arg Lys Arg Ala Ser Ala Thr Gln 
1               5                   10                  15      


Leu Tyr Gln Thr Cys Lys Ala Ser Gly Thr Cys Pro Pro Asp Val Ile 
            20                  25                  30          


Pro Lys Val Glu Gly Thr Thr Ile Ala Asp Gln Ile Leu Arg Tyr Gly 
        35                  40                  45              


Ser Leu Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly 
    50                  55                  60                  


Thr Gly Gly Arg Thr Gly Tyr Val Pro Leu Gly Ser Thr Pro Pro Ser 
65                  70                  75                  80  


Glu Ala Ile Pro Leu Gln Pro Ile Arg Pro Pro Val Thr Val Asp Thr 
                85                  90                  95      


Val Gly Pro Leu Asp Ser Ser Ile Val Ser Leu Ile Glu Glu Ser Ser 
            100                 105                 110         


Phe Ile Asp Ala Gly Ala Pro Ala 
        115                 120 


<210>  14
<211>  697
<212>  DNA
<213>  Artificial

<220>
<223>  cDNA sequence encoding a fusion polypeptide comprising the HPV-16
       L2 amino terminal peptide sequence encompassing amino acids 13 
       through 92 fused at the amino terminus of the streptavidin core 
       protein

<400>  14
ttaattaacc atggccagcg ccacccagct gtacaagacc tgcaagcagg ccggcacctg     60

cccccccgac atcatcccca aggtggaggg caagaccatc gccgaccaga tcctgcagta    120

cggcagcatg ggcgtgttct tcggcggcct gggcatcggc accggcagcg gcaccggcgg    180

caggaccggc tacatccccc tgggcaccag gccccccacc gccaccgaca ccctggcccc    240

cgtgaggccc cccgccggcg gtggaggatc tggtggtggt ggttctggtg gaggtggaag    300

ttctggaatt actggaactt ggtacaacca gcttggatct actttcattg tgactgctgg    360

agctgatggt gctcttactg gtacttacga gtctgctgtt ggaaatgctg agtcaagata    420

cgtgttgaca ggaagatacg attctgctcc agctactgat ggatctggaa ctgctcttgg    480

atggactgtt gcttggaaga acaactacag gaacgctcac tctgctacta cttggagtgg    540

acagtatgtt ggaggagctg aggctaggat taacactcag tggcttctta cttctggaac    600

tactgaggct aacgcttgga agtctactct tgtgggacac gatactttca ctaaggtgaa    660

gccatctgct gcttctgccg ggtagcctag gctcgag                             697


<210>  15
<211>  675
<212>  DNA
<213>  Artificial

<220>
<223>  cDNA sequence encoding a fusion polypeptide comprising the HPV-16
       L2 amino terminal peptide sequence encompassing amino acids 13 
       through 92 fused at the amino terminus of the streptavidin core 
       protein and linked by a (Gly4Ser)3 flexible linker sequence

<400>  15
atggccagcg ccacccagct gtacaagacc tgcaagcagg ccggcacctg cccccccgac     60

atcatcccca aggtggaggg caagaccatc gccgaccaga tcctgcagta cggcagcatg    120

ggcgtgttct tcggcggcct gggcatcggc accggcagcg gcaccggcgg caggaccggc    180

tacatccccc tgggcaccag gccccccacc gccaccgaca ccctggcccc cgtgaggccc    240

cccgccggcg gtggaggatc tggtggtggt ggttctggtg gaggtggaag ttctggaatt    300

actggaactt ggtacaacca gcttggatct actttcattg tgactgctgg agctgatggt    360

gctcttactg gtacttacga gtctgctgtt ggaaatgctg agtcaagata cgtgttgaca    420

ggaagatacg attctgctcc agctactgat ggatctggaa ctgctcttgg atggactgtt    480

gcttggaaga acaactacag gaacgctcac tctgctacta cttggagtgg acagtatgtt    540

ggaggagctg aggctaggat taacactcag tggcttctta cttctggaac tactgaggct    600

aacgcttgga agtctactct tgtgggacac gatactttca ctaaggtgaa gccatctgct    660

gcttctgccg ggtag                                                     675


<210>  16
<211>  224
<212>  PRT
<213>  Artificial

<220>
<223>  HPV-16 L2 amino terminal-streptavidin fusion polypeptide

<400>  16

Met Ala Ser Ala Thr Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr 
1               5                   10                  15      


Cys Pro Pro Asp Ile Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Asp 
            20                  25                  30          


Gln Ile Leu Gln Tyr Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly 
        35                  40                  45              


Ile Gly Thr Gly Ser Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu 
    50                  55                  60                  


Gly Thr Arg Pro Pro Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro 
65                  70                  75                  80  


Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                85                  90                  95      


Ser Ser Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe 
            100                 105                 110         


Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser 
        115                 120                 125             


Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp 
    130                 135                 140                 


Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val 
145                 150                 155                 160 


Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser 
                165                 170                 175     


Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu 
            180                 185                 190         


Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val 
        195                 200                 205             


Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ala Gly 
    210                 215                 220                 


