                               SEQUENCE LISTING                               

<110> Bisson, Linda F.
      Linderholm, Angela
      Dietzel, Kevin L.
      The Regents of the University of California

<120> Compositions and Methods for Reducing H-2S Levels in
      Fermented Beverages

<130> 02307O-177920PC

<140> WO Not yet assigned
<141> Not yet assigned

<150> US 60/918,616
<151> 2007-03-16

<150> US 60/959,366
<151> 2007-07-12

<160> 93                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD932 allele

<400> 1
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaacggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgacattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttaagcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 2
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD950 allele

<400> 2
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctggcattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaagga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc attaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggataag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 3
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:sulfide
      inactive yeast assimilatory sulfite reductase
      alpha subunit (Met 10, MET10) consensus sequence

<220> 
<221> MOD_RES
<222> (135)
<223> Xaa = Thr or Asn

<220> 
<221> MOD_RES
<222> (172)
<223> Xaa = Ala or Thr

<220> 
<221> MOD_RES
<222> (511)
<223> Xaa = Thr or Ile

<220> 
<221> MOD_RES
<222> (590)
<223> Xaa = Glu or Lys

<220> 
<221> MOD_RES
<222> (662)
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys,
      Leu, Met, Asn, Pro, Gln, Arg, Ser, Val, Trp or
      Tyr, not Thr

<400> 3
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Xaa Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Xaa Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Xaa Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Xaa Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Xaa Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 4
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:modified
      sulfide inactive yeast assimilatory sulfite
      reductase alpha subunit (Met 10, MET10) based on
      strain UCD932 sequence

<220> 
<221> MOD_RES
<222> (662)
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys,
      Leu, Met, Asn, Pro, Gln, Arg, Ser, Val, Trp or
      Tyr, not Thr

<400> 4
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Asn Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Thr Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Thr Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Glu Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Xaa Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 5
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:sulfide
      inactive yeast assimilatory sulfite reductase
      alpha subunit (Met 10, MET10)

<220> 
<221> MOD_RES
<222> (135)
<223> Xaa = Thr or Asn

<220> 
<221> MOD_RES
<222> (172)
<223> Xaa = Ala or Thr

<220> 
<221> MOD_RES
<222> (511)
<223> Xaa = Thr or Ile

<220> 
<221> MOD_RES
<222> (590)
<223> Xaa = Glu or Lys

<220> 
<221> MOD_RES
<222> (662)
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys,
      Leu, Met, Asn, Pro, Gln, Arg, Val, Trp or Tyr, not
      Thr or Ser

<400> 5
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Xaa Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Xaa Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Xaa Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Xaa Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Xaa Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 6
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:sulfide
      inactive yeast assimilatory sulfite reductase
      alpha subunit (Met 10, MET10)

<220> 
<221> MOD_RES
<222> (135)
<223> Xaa = Thr or Asn

<220> 
<221> MOD_RES
<222> (172)
<223> Xaa = Ala or Thr

<220> 
<221> MOD_RES
<222> (511)
<223> Xaa = Thr or Ile

<220> 
<221> MOD_RES
<222> (590)
<223> Xaa = Glu or Lys

<220> 
<221> MOD_RES
<222> (662)
<223> Xaa = Lys, Arg, His, Gln or Asn

<400> 6
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Xaa Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Xaa Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Xaa Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Xaa Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Xaa Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 7
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:sulfide
      inactive yeast assimilatory sulfite reductase
      alpha subunit (Met 10, MET10)

<220> 
<221> MOD_RES
<222> (135)
<223> Xaa = Thr or Asn

<220> 
<221> MOD_RES
<222> (172)
<223> Xaa = Ala or Thr

<220> 
<221> MOD_RES
<222> (511)
<223> Xaa = Thr or Ile

<220> 
<221> MOD_RES
<222> (590)
<223> Xaa = Glu or Lys

<400> 7
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Xaa Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Xaa Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Lys Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Xaa Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Lys Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 8
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain S288c allele

<400> 8
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgctacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctggcattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtgccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 9
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD522 allele

<400> 9
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgacattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaarga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc aytaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 10
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD934 allele

<400> 10
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctggcattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaagga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc attaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggataag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 11
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD938 allele

<400> 11
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaacggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgacattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggctttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 12
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD939 allele

<400> 12
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgrcattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatcag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 13
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD940 allele

<400> 13
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctamcggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgacattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgy cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 14
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD942 allele

<400> 14
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaacggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgacattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggctttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 15
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD956 allele

<400> 15
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctgacattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaaaga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc actaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggatgag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcatcatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 16
<211> 3108
<212> DNA
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD957 allele

<400> 16
atgccagttg agtttgctac caatcctttt ggcgaggcca aaaatgcaac ttcactgcca 60    
aaatatggta cacccgtaac tgccatttca tctgtgctgt tcaataacgt ggactccatt 120   
tttgcttaca agtccttttc tcaacccgat ttgttacacc aagatctaaa aaaatggtct 180   
gaaaagcgtg gtaacgaatc acgtgggaag ccatttttcc aagagctgga tatcagatct 240   
ggcgctggtt tggctccttt agggttttct catggattga agaacactac agcaattgtt 300   
gctccagggt tttcgctgcc atacttcatt aactctttga aaaccgtctc tcatgatggt 360   
aagtttcttt tgaatgttgg tgctttaaac tacgacaatg ctaccggctc tgtcaccaac 420   
gattatgtaa ccgcattgga tgctgcttcc aagctgaagt atggtgtcgt gactccgatt 480   
tccgctaacg aggtacaaag tgtcgcctta ctggcattgg cgattgccac tttcagtaat 540   
aactccggag ctatcaattt atttgacgga ttaaactact cgaaaaccgt cttgccgttg 600   
gtcgaatctg ttcctgaggc atctattttg gcaaaactat ccaaagttat tgcaccagat 660   
gctgcctttg atgatgtctt ggataagttt aatgaattga ctggattgag actacataat 720   
ttccaatact ttggtgctca ggatgctgaa actgtgttta tcacttatgg gtctttagaa 780   
tccgaattgt tcaactctgc gattagtggt aataattcca aaatcgggtt aatcaacgtc 840   
agagtaccat taccttttaa cgttgctaag tttgtcactc acgttccatc cactaccaaa 900   
caaattgttg ttataggcca aactttggat ggttcttcgc cttctttctt gagatctcaa 960   
gtttcagccg ccttatttta ccacggccgc acctcaatta gcgtttctga gtacatctat 1020  
caaccagatt tcatttggtc cccaaaagct gtcaaatcaa ttgtatcgtc attcatccct 1080  
gaattcactt acaatgccga ttcatctttc ggcgaaggat tcatttattg ggcctctgat 1140  
aagagtatca atattgatgt tgcctccaaa cttgtgaaag ctctgtcttt ggaagatggg 1200  
aaatttgtgt ctttgagaac gaaatttgat aacttggcta atgctggtac cttccaagct 1260  
caatttgtga cctcgaagga acagatacct gtttcaaaca tcgattctac gaaattatca 1320  
gtcgttgaag atgtcagttt attgaagcat ttagacgtag ctgctaccgt cgcagaacaa 1380  
ggttcaattg cgttggtttc ccaaaaggca gttaaagatt tggatttaaa ttctgtagaa 1440  
agttacgtca agaatttggg aattcctgaa tcattcctaa tatctattgc gaagaaaaac 1500  
atcaaattgt ttatcatcga tggtgagacc attaacgacg agtccaaatt gtccttgttt 1560  
atccaagccg ttttctggaa attggccttc ggtctagatg tcgcagaatg taccaaccgt 1620  
atctggaaaa gcattgattc aggtgcagac atttcagcag cctcgatttc tgaatttctc 1680  
actggtgcat tcaaaaactt cctcagtgag gttccgctag cgctgtacac taaattttct 1740  
gaaataaaca ttgaaaagaa agaggataag gaagagcctg cagctttacc aattttcgtt 1800  
aatgaaacat ctttcctccc aaataacagt accattgaag aaataccatt acctgagacc 1860  
tctgagatct ctgatattgc caagaagttg tccttcaaag aggcatatga agttgagaat 1920  
aaactaagac ccgatttacc cgtcaagaac ttcgtcgtga aagttaaaga aaatagacgt 1980  
gttacgcctg ctgattatga tagatatatt ttccatattg aattcgatat ttctggtact 2040  
ggaatgactt atgacatcgg tgaagccctc ggtattcatg ccagaaacaa tgaatctttg 2100  
gtcaaagaat tcttaacctt ctatggtcta aatgaatccg atgttgtctt agtccccaac 2160  
aaggacaacc accatttgtt agaaacaaga accgtcttac aagcatttgt ggaaaatttg 2220  
gatattttcg gtaaaccacc aaaaagattt tacgaatcat tgattccata tgcctctaac 2280  
gaagaggaga agaaaaaatt agaggatttg gttactcctg ccggtgcagt agatttgaag 2340  
agatttcaag atgtggagta ttatacatat gctgacattt ttgaattgtt cccatctgtt 2400  
cgcccatctc ttgaggaact tgttactatc attgaaccat tgaagagaag agaatactca 2460  
attgcctcct ctcagaaagt tcatccaaat gaagttcatt tattgatcgt tgttgttgat 2520  
tgggtggata ataaaggaag aaaaaggtac ggtcaagctt ctaagtatat ctcagacctt 2580  
gctgtcggtt cagaattggt cgttagcgtt aaaccatctg ttatgaaatt accaccatct 2640  
ccaaagcaac cagttattat gagtggttta ggtactggtt tggcaccatt caaggccatt 2700  
gttgaagaga aattatggca aaagcagcaa ggttatgaga ttggtgaagt cttcctatat 2760  
ctaggttcaa gacacaaaag agaagaatat ttatatggtg agttatggga ggcttacaaa 2820  
gatgcaggta ttatcacaca catcggcgct gctttctcaa gagaccaacc tcaaaaaatt 2880  
tacattcaag atcgtatcaa agagaatttg gatgaattaa aaactgcaat gattgataat 2940  
aaaggttcat tttacttgtg tggccctact tggccagttc cagatattac tcaagctttg 3000  
caagacattc tggctaaaga cgccgaggaa agaggcatca aagtcgactt ggatgccgca 3060  
attgaagaat taaaggaagc atcaagatac attttagaag tctactaa              3108  


<210> 17
<211> 1035
<212> PRT
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain S288c allele

<400> 17
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Thr Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Ala Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Thr Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Glu Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Thr Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 18
<211> 1035
<212> PRT
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD932 allele

<400> 18
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Asn Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Thr Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Thr Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Glu Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Lys Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 19
<211> 1035
<212> PRT
<213> Saccharomyces cerevisiae

<220> 
<223> yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10), strain UCD950 allele

<400> 19
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Thr Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Ala Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Ile Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Lys Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Thr Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 20
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:DNA sequence
      surrounding residue 662 of yeast assimilatory
      sulfite reductase alpha subunit (Met 10, MET10),
      strain S288c and UCD950 alleles

<400> 20
ttcgtcgtga aagttaaaga aaatagacgt gttacgcctg ctgattatga            50    


<210> 21
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:DNA sequence
      surrounding residue 662 of yeast assimilatory
      sulfite reductase alpha subunit (Met 10, MET10),
      strain UCD932 allele

<400> 21
ttcgtcgtga aagttaaaga aaatagacgt gttaagcctg ctgattatga            50    


<210> 22
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:DNA sequence
      surrounding residue 662 of yeast assimilatory
      sulfite reductase alpha subunit (Met 10, MET10),
      strain S288c and UCD950 alleles

<400> 22
aatagacgtg ttacgcctgc tgattat                                     27    


<210> 23
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:DNA sequence
      surrounding residue 662 of yeast assimilatory
      sulfite reductase alpha subunit (Met 10, MET10),
      strain UCD932 allele

<400> 23
aatagacgtg ttaagcctgc tgattat                                     27    


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:amino acid
      sequence surrounding residue 662 of yeast
      assimilatory sulfite reductase alpha subunit (Met
      10, MET10), strains S288c, UCD932 and UCD950 alleles

<220> 
<221> MOD_RES
<222> (5)
<223> Xaa = Thr or Lys

<400> 24
Asn Arg Arg Val Xaa Pro Ala Asp Tyr                              
  1               5                


<210> 25
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:subsequence of
      yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10) catalytic region of Saccharomyces
      cerevisiae strain UCD932

<400> 25
Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn Lys Leu Arg  
  1               5                  10                  15    

Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys Glu Asn Arg  
             20                  25                  30        

Arg Val Lys Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His Ile Glu Phe  
         35                  40                  45            

Asp Ile                                                          
     50


<210> 26
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:subsequence of
      yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10) catalytic region of Saccharomyces
      cerevisiae strain S288c

<400> 26
Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn Lys Leu Arg  
  1               5                  10                  15    

Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys Glu Asn Arg  
             20                  25                  30        

Arg Val Thr Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His Ile Glu Phe  
         35                  40                  45            

Asp Ile                                                          
     50


<210> 27
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:subsequence of
      yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10) catalytic region of Saccharomyces
      cerevisiae (carlsbergensis)

<400> 27
Lys Lys Leu Ser Phe Lys Glu Ala Tyr Gly Val Glu Asn Lys Leu Arg  
  1               5                  10                  15    

Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys Glu Asn Arg  
             20                  25                  30        

Arg Val Thr Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His Ile Glu Phe  
         35                  40                  45            

Asp Ile                                                          
     50


<210> 28
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:subsequence of
      yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10) catalytic region of Kluyveromyces
      lactis

<400> 28
Lys Lys Leu Thr Phe Gln Glu Ala Tyr Gly Val Ser Gln Gln Leu Arg  
  1               5                  10                  15    

Pro Asp Leu Pro Val Asn Asn Tyr Val Val Lys Val Lys Glu Asn Arg  
             20                  25                  30        

Arg Val Thr Pro Asp Asp Tyr Asp Arg Tyr Ile Phe His Ile Glu Phe  
         35                  40                  45            

Asp Ile                                                          
     50


<210> 29
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:subsequence of
      yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10) catalytic region of Yarowwia
      lipolytica

<400> 29
Lys Arg Val Val Phe Lys Glu Ala Tyr Gly Thr Glu Asn Ser Leu Arg  
  1               5                  10                  15    

Pro Asp Ile Ser Thr Lys Asn Phe Val Val Lys Val Gln Glu Lys Arg  
             20                  25                  30        

Arg Val Thr Pro Glu Asn Tyr Asp Arg Asn Ile Phe His Val Glu Phe  
         35                  40                  45            

Asp Ile                                                          
     50


<210> 30
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:subsequence of
      yeast assimilatory sulfite reductase alpha subunit
      (Met 10, MET10) catalytic region of
      Schizosaccharomyces pombe

<400> 30
Lys Gln Ile Ile Phe Pro Glu Ala Tyr Lys Lys Lys Asp Ala Leu Arg  
  1               5                  10                  15    

Pro Asp Val Ser Glu Lys Val Phe Thr Val His Val Arg Ala Asn Lys  
             20                  25                  30        

Arg Leu Thr Pro Ala Glu Tyr Asn Arg Asn Ile Phe His Ile Glu Phe  
         35                  40                  45            

Asp Leu                                                          
     50


<210> 31
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:conserved yeast
      motif in sulfite active sulfite reductase
      catalytic region

<220> 
<221> MOD_RES
<222> (1)
<223> Xaa = Asn or Lys

<220> 
<221> MOD_RES
<222> (2)
<223> Xaa = Arg or Lys

<220> 
<221> MOD_RES
<222> (4)
<223> Xaa = Val or Leu

<220> 
<221> MOD_RES
<222> (7)
<223> Xaa = Ala, Asp or Glu

<220> 
<221> MOD_RES
<222> (8)
<223> Xaa = Asp, Asn or Glu

<220> 
<221> MOD_RES
<222> (12)
<223> Xaa = Tyr or Asn

<220> 
<221> MOD_RES
<222> (16)
<223> Xaa = Ile or Val

<220> 
<221> MOD_RES
<222> (20)
<223> Xaa = Ile or Leu

<400> 31
Xaa Xaa Arg Xaa Thr Pro Xaa Xaa Tyr Asx Arg Xaa Ile Phe His Xaa  
  1               5                  10                  15    

Glu Phe Asp Xaa                                                  
             20


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:conserved yeast
      motif in sulfite inactive sulfite reductase
      catalytic region

<220> 
<221> MOD_RES
<222> (1)
<223> Xaa = Asn or Lys

<220> 
<221> MOD_RES
<222> (2)
<223> Xaa = Arg or Lys

<220> 
<221> MOD_RES
<222> (4)
<223> Xaa = Val or Leu

<220> 
<221> MOD_RES
<222> (5)
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys,
      Leu, Met, Asn, Pro, Gln, Arg, Ser, Val, Trp or
      Tyr, not Thr

<220> 
<221> MOD_RES
<222> (7)
<223> Xaa = Ala, Asp or Glu

<220> 
<221> MOD_RES
<222> (8)
<223> Xaa = Asp, Asn or Glu

<220> 
<221> MOD_RES
<222> (12)
<223> Xaa = Tyr or Asn

<220> 
<221> MOD_RES
<222> (16)
<223> Xaa = Ile or Val

<220> 
<221> MOD_RES
<222> (20)
<223> Xaa = Ile or Leu

<400> 32
Xaa Xaa Arg Xaa Xaa Pro Xaa Xaa Tyr Asx Arg Xaa Ile Phe His Xaa  
  1               5                  10                  15    

Glu Phe Asp Xaa                                                  
             20


<210> 33
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:sulfide
      inactive yeast assimilatory sulfite reductase
      alpha subunit (Met 10, MET10)

<220> 
<221> MOD_RES
<222> (135)
<223> Xaa = Thr or Asn

<220> 
<221> MOD_RES
<222> (172)
<223> Xaa = Ala or Thr

<220> 
<221> MOD_RES
<222> (511)
<223> Xaa = Thr or Ile

<220> 
<221> MOD_RES
<222> (590)
<223> Xaa = Glu or Lys

<220> 
<221> MOD_RES
<222> (662)
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys,
      Leu, Met, Asn, Pro, Gln, Arg, Ser, Val or Trp, not
      Thr, Ser or Tyr

<400> 33
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Xaa Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Xaa Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Xaa Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Xaa Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Xaa Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 34
<211> 1035
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:sulfide
      inactive yeast assimilatory sulfite reductase
      alpha subunit (Met 10, MET10)

<220> 
<221> MOD_RES
<222> (135)
<223> Xaa = Thr or Asn

<220> 
<221> MOD_RES
<222> (172)
<223> Xaa = Ala or Thr

<220> 
<221> MOD_RES
<222> (511)
<223> Xaa = Thr or Ile

<220> 
<221> MOD_RES
<222> (590)
<223> Xaa = Glu or Lys

<220> 
<221> MOD_RES
<222> (662)
<223> Xaa = large or bulky amino acid, Lys, Arg, His,
      Gln, Asn, Glu, Asp, Ile, Leu, Val, Phe, Tyr or Trp

<400> 34
Met Pro Val Glu Phe Ala Thr Asn Pro Phe Gly Glu Ala Lys Asn Ala  
  1               5                  10                  15    

Thr Ser Leu Pro Lys Tyr Gly Thr Pro Val Thr Ala Ile Ser Ser Val  
             20                  25                  30        

Leu Phe Asn Asn Val Asp Ser Ile Phe Ala Tyr Lys Ser Phe Ser Gln  
         35                  40                  45            

Pro Asp Leu Leu His Gln Asp Leu Lys Lys Trp Ser Glu Lys Arg Gly  
     50                  55                  60                

Asn Glu Ser Arg Gly Lys Pro Phe Phe Gln Glu Leu Asp Ile Arg Ser  
 65                  70                  75                  80

Gly Ala Gly Leu Ala Pro Leu Gly Phe Ser His Gly Leu Lys Asn Thr  
                 85                  90                  95    

Thr Ala Ile Val Ala Pro Gly Phe Ser Leu Pro Tyr Phe Ile Asn Ser  
            100                 105                 110        

Leu Lys Thr Val Ser His Asp Gly Lys Phe Leu Leu Asn Val Gly Ala  
        115                 120                 125            

Leu Asn Tyr Asp Asn Ala Xaa Gly Ser Val Thr Asn Asp Tyr Val Thr  
    130                 135                 140                

Ala Leu Asp Ala Ala Ser Lys Leu Lys Tyr Gly Val Val Thr Pro Ile  
145                 150                 155                 160

Ser Ala Asn Glu Val Gln Ser Val Ala Leu Leu Xaa Leu Ala Ile Ala  
                165                 170                 175    

Thr Phe Ser Asn Asn Ser Gly Ala Ile Asn Leu Phe Asp Gly Leu Asn  
            180                 185                 190        

Tyr Ser Lys Thr Val Leu Pro Leu Val Glu Ser Val Pro Glu Ala Ser  
        195                 200                 205            

Ile Leu Ala Lys Leu Ser Lys Val Ile Ala Pro Asp Ala Ala Phe Asp  
    210                 215                 220                

Asp Val Leu Asp Lys Phe Asn Glu Leu Thr Gly Leu Arg Leu His Asn  
225                 230                 235                 240

Phe Gln Tyr Phe Gly Ala Gln Asp Ala Glu Thr Val Phe Ile Thr Tyr  
                245                 250                 255    

Gly Ser Leu Glu Ser Glu Leu Phe Asn Ser Ala Ile Ser Gly Asn Asn  
            260                 265                 270        

Ser Lys Ile Gly Leu Ile Asn Val Arg Val Pro Leu Pro Phe Asn Val  
        275                 280                 285            

Ala Lys Phe Val Thr His Val Pro Ser Thr Thr Lys Gln Ile Val Val  
    290                 295                 300                

Ile Gly Gln Thr Leu Asp Gly Ser Ser Pro Ser Phe Leu Arg Ser Gln  
305                 310                 315                 320

Val Ser Ala Ala Leu Phe Tyr His Gly Arg Thr Ser Ile Ser Val Ser  
                325                 330                 335    

Glu Tyr Ile Tyr Gln Pro Asp Phe Ile Trp Ser Pro Lys Ala Val Lys  
            340                 345                 350        

Ser Ile Val Ser Ser Phe Ile Pro Glu Phe Thr Tyr Asn Ala Asp Ser  
        355                 360                 365            

Ser Phe Gly Glu Gly Phe Ile Tyr Trp Ala Ser Asp Lys Ser Ile Asn  
    370                 375                 380                

Ile Asp Val Ala Ser Lys Leu Val Lys Ala Leu Ser Leu Glu Asp Gly  
385                 390                 395                 400

Lys Phe Val Ser Leu Arg Thr Lys Phe Asp Asn Leu Ala Asn Ala Gly  
                405                 410                 415    

Thr Phe Gln Ala Gln Phe Val Thr Ser Lys Glu Gln Ile Pro Val Ser  
            420                 425                 430        

Asn Ile Asp Ser Thr Lys Leu Ser Val Val Glu Asp Val Ser Leu Leu  
        435                 440                 445            

Lys His Leu Asp Val Ala Ala Thr Val Ala Glu Gln Gly Ser Ile Ala  
    450                 455                 460                

Leu Val Ser Gln Lys Ala Val Lys Asp Leu Asp Leu Asn Ser Val Glu  
465                 470                 475                 480

Ser Tyr Val Lys Asn Leu Gly Ile Pro Glu Ser Phe Leu Ile Ser Ile  
                485                 490                 495    

Ala Lys Lys Asn Ile Lys Leu Phe Ile Ile Asp Gly Glu Thr Xaa Asn  
            500                 505                 510        

Asp Glu Ser Lys Leu Ser Leu Phe Ile Gln Ala Val Phe Trp Lys Leu  
        515                 520                 525            

Ala Phe Gly Leu Asp Val Ala Glu Cys Thr Asn Arg Ile Trp Lys Ser  
    530                 535                 540                

Ile Asp Ser Gly Ala Asp Ile Ser Ala Ala Ser Ile Ser Glu Phe Leu  
545                 550                 555                 560

Thr Gly Ala Phe Lys Asn Phe Leu Ser Glu Val Pro Leu Ala Leu Tyr  
                565                 570                 575    

Thr Lys Phe Ser Glu Ile Asn Ile Glu Lys Lys Glu Asp Xaa Glu Glu  
            580                 585                 590        

Pro Ala Ala Leu Pro Ile Phe Val Asn Glu Thr Ser Phe Leu Pro Asn  
        595                 600                 605            

Asn Ser Thr Ile Glu Glu Ile Pro Leu Pro Glu Thr Ser Glu Ile Ser  
    610                 615                 620                

Asp Ile Ala Lys Lys Leu Ser Phe Lys Glu Ala Tyr Glu Val Glu Asn  
625                 630                 635                 640

Lys Leu Arg Pro Asp Leu Pro Val Lys Asn Phe Val Val Lys Val Lys  
                645                 650                 655    

Glu Asn Arg Arg Val Xaa Pro Ala Asp Tyr Asp Arg Tyr Ile Phe His  
            660                 665                 670        

Ile Glu Phe Asp Ile Ser Gly Thr Gly Met Thr Tyr Asp Ile Gly Glu  
        675                 680                 685            

Ala Leu Gly Ile His Ala Arg Asn Asn Glu Ser Leu Val Lys Glu Phe  
    690                 695                 700                

Leu Thr Phe Tyr Gly Leu Asn Glu Ser Asp Val Val Leu Val Pro Asn  
705                 710                 715                 720

Lys Asp Asn His His Leu Leu Glu Thr Arg Thr Val Leu Gln Ala Phe  
                725                 730                 735    

Val Glu Asn Leu Asp Ile Phe Gly Lys Pro Pro Lys Arg Phe Tyr Glu  
            740                 745                 750        

Ser Leu Ile Pro Tyr Ala Ser Asn Glu Glu Glu Lys Lys Lys Leu Glu  
        755                 760                 765            

Asp Leu Val Thr Pro Ala Gly Ala Val Asp Leu Lys Arg Phe Gln Asp  
    770                 775                 780                

Val Glu Tyr Tyr Thr Tyr Ala Asp Ile Phe Glu Leu Phe Pro Ser Val  
785                 790                 795                 800

Arg Pro Ser Leu Glu Glu Leu Val Thr Ile Ile Glu Pro Leu Lys Arg  
                805                 810                 815    

Arg Glu Tyr Ser Ile Ala Ser Ser Gln Lys Val His Pro Asn Glu Val  
            820                 825                 830        

His Leu Leu Ile Val Val Val Asp Trp Val Asp Asn Lys Gly Arg Lys  
        835                 840                 845            

Arg Tyr Gly Gln Ala Ser Lys Tyr Ile Ser Asp Leu Ala Val Gly Ser  
    850                 855                 860                

Glu Leu Val Val Ser Val Lys Pro Ser Val Met Lys Leu Pro Pro Ser  
865                 870                 875                 880

Pro Lys Gln Pro Val Ile Met Ser Gly Leu Gly Thr Gly Leu Ala Pro  
                885                 890                 895    

Phe Lys Ala Ile Val Glu Glu Lys Leu Trp Gln Lys Gln Gln Gly Tyr  
            900                 905                 910        

Glu Ile Gly Glu Val Phe Leu Tyr Leu Gly Ser Arg His Lys Arg Glu  
        915                 920                 925            

Glu Tyr Leu Tyr Gly Glu Leu Trp Glu Ala Tyr Lys Asp Ala Gly Ile  
    930                 935                 940                

Ile Thr His Ile Gly Ala Ala Phe Ser Arg Asp Gln Pro Gln Lys Ile  
945                 950                 955                 960

Tyr Ile Gln Asp Arg Ile Lys Glu Asn Leu Asp Glu Leu Lys Thr Ala  
                965                 970                 975    

Met Ile Asp Asn Lys Gly Ser Phe Tyr Leu Cys Gly Pro Thr Trp Pro  
            980                 985                 990        

Val Pro Asp Ile Thr Gln Ala Leu Gln Asp Ile Leu Ala Lys Asp Ala  
        995                1000                1005            

Glu Glu Arg Gly Ile Lys Val Asp Leu Asp Ala Ala Ile Glu Glu Leu  
   1010                1015                1020                

Lys Glu Ala Ser Arg Tyr Ile Leu Glu Val Tyr                      
1025               1030                1035


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      HOM2-F

<400> 35
cacttaagta cacatacaaa                                             20    


<210> 36
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      HOM2-R

<400> 36
gggtcagcga gagaatt                                                17    


<210> 37
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      HOM6-F

<400> 37
cctggtggta aagttggg                                               18    


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      HOM6-R

<400> 38
gattgtagaa gattgagtag                                             20    


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      SER33-F

<400> 39
ggaatctccc aggtttaat                                              19    


<210> 40
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      SER33-R

<400> 40
gggcaatcaa aggctat                                                17    


<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET1-F

<400> 41
cgctaataaa ctcgctacaa aag                                         23    


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET1-R

<400> 42
cgtccttttt gctcaatatc c                                           21    


<210> 43
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET5-F

<400> 43
gctgcaagca gttatataaa gtg                                         23    


<210> 44
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET5-R

<400> 44
aaaaccgaac tagccgaag                                              19    


<210> 45
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET8-F

<400> 45
aaaatcgcta caaagtccg                                              19    


<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET8-R

<400> 46
gcattgttgt tcgttctcc                                              19    


<210> 47
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      PCR-MET10-F

<400> 47
cggatcccca atcaccataa cactt                                       25    


<210> 48
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      PCR-MET10-R

<400> 48
gccgcggtag ggtcttcagg acgag                                       25    


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET10-F-KO

<400> 49
caaatagttt cgtttagatg g                                           21    


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET10-R-KO

<400> 50
gtataatgtg atggttagtt                                             20    


<210> 51
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET10-hphMX-F

<400> 51
actgtgttta tcacttatgg gtctttagaa tccgaattgt attttgatgg ccgcacgg   58    


<210> 52
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR primer
      MET10-hphMX-R

<400> 52
aacaattcaa aaatgtcagc atatgtataa tactccacat aatcgacagc agtatagcga 60    
cca                                                               63    


<210> 53
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR
      confirmation primer JKKanRE

<400> 53
gggcgacagt cacatcat                                               18    


<210> 54
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:PCR
      confirmation primer HYGROB CHK_R

<400> 54
tgacggtgtc gtccatcac                                              19    


<210> 55
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET1-S1F

<400> 55
tggggagagt tctggtatgc aag                                         23    


<210> 56
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET1-S2F

<400> 56
cagatggtta tctcagataa tggag                                       25    


<210> 57
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET1-S3F

<400> 57
tttcttcaaa gatcacggat atatt                                       25    


<210> 58
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET1-S1R

<400> 58
gctatatcac gttgagtagc gg                                          22    


<210> 59
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET1-S2R

<400> 59
ggtactacac cctctgtgac agtt                                        24    


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET1-S3R

<400> 60
ctcagttttt ggcattgcca                                             20    


<210> 61
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S1F

<400> 61
cctaataaac ttccattggt gatta                                       25    


<210> 62
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S2F

<400> 62
ccgttttaca gggtgtctct aaga                                        24    


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S3F

<400> 63
gacgcgatct tgacgaagct                                             20    


<210> 64
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S4F

<400> 64
gaatctggtt actggccatt gt                                          22    


<210> 65
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S5F

<400> 65
ctgaaaaatg acaccgactt gg                                          22    


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S6F

<400> 66
tggcttgctc tggatcactt                                             20    


<210> 67
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S7F

<400> 67
cgatgtcggt ttagttgcta tagtt                                       25    


<210> 68
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S8F

<400> 68
tggtaatcaa catttggtta tctct                                       25    


<210> 69
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S1R

<400> 69
gggcaaccag tcattctcat aa                                          22    


<210> 70
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S2R

<400> 70
cttcgacacc catatcatct acag                                        24    


<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S3R

<400> 71
caattttccc atatcagcga                                             20    


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S4R

<400> 72
catcatcaac agcagcgccg                                             20    


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S5R

<400> 73
ctgatcgaag gcagccttgc                                             20    


<210> 74
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S6R

<400> 74
catatggctc tgaatcaatc aataa                                       25    


<210> 75
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S7R

<400> 75
ttcacaactt ttttgacaga agaa                                        24    


<210> 76
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET5-S8R

<400> 76
cgttagcaat ctccaaggta ggaa                                        24    


<210> 77
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET8-S1F

<400> 77
gcagtgactt caaagacgaa tacc                                        24    


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET8-S2F

<400> 78
ctggaggacg ctgtcgtcaa                                             20    


<210> 79
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET8-S1R

<400> 79
tcatctctta ctagagcgcc aa                                          22    


<210> 80
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET8-S2R

<400> 80
ggtcccagtt cggattgata a                                           21    


<210> 81
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ1-F

<400> 81
agtcatcttc gagcaaa                                                17    


<210> 82
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ2-F

<400> 82
tcatgatggt aagtttc                                                17    


<210> 83
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ3-F

<400> 83
tcaacgtcag agtgccatt                                              19    


<210> 84
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ4-F

<400> 84
atcagtcgtt gaagatgtc                                              19    


<210> 85
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ5-F

<400> 85
ctgagatctc tgatattgc                                              19    


<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ6-F

<400> 86
tgcagtagat ttgaagagat                                             20    


<210> 87
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ7-F

<400> 87
cacacacatc ggcgct                                                 16    


<210> 88
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ1-R

<400> 88
cggagtcacg acaccat                                                17    


<210> 89
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ2-R

<400> 89
ggctgaaact tgagatctc                                              19    


<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ3-R

<400> 90
cttgacgtaa ctttctacag                                             20    


<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ4-R

<400> 91
tcataatcag caggcgtaac                                             20    


<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ5-R

<400> 92
cttctcttca atggttcaat                                             20    


<210> 93
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:MET sequencing
      primer MET10-SEQ6-R

<400> 93
agtagggcca gacaagt                                                17    


