
                                SEQUENCE LISTING

<110> Yale University
      
      BREAKER, Ronald R.

<120> PREQ1 RIBOSWITCHES, STRUCTURE-BASED
  COMPOUND DESIGN WITH PREQ1 RIBOSWITCHES, AND METHODS AND
  COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES
  

<130> 25006.0029P1

<150> 60/919,410          
<151> 2007-03-22  

<160> 49

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 1
gagcctggaa ttcataggcg ctttgc                                      26

<210> 2
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 2
ttttctggat ccatgattcc tctcc                                       25

<210> 3
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 3
cgagaattca taatgaaacg aaccgtcact atag                             34

<210> 4
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 4
gtactttttt ctttttcgtt aacagcctag gtgc                             34

<210> 5
<211> 59
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 5
gaauuccgug caaugcacgg gagagguucg cgaacucccu cuauaaaaaa cuauggaaa  59

<210> 6
<211> 74
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 6
guaaauauaa ucuuguugcu uaaaaaaacg aauaacgugg uucgaaacca ucccacguaa 60
aaaaacuaag gaga                                                   74

<210> 7
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 7
aaauuccgug caccgcgcgg gagagguucg cgaacucccu cuauaaaaac uauggaaa   58

<210> 8
<211> 73
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 8
guaaaauaua aucuuguugc uuaaaaaacg aauaacgugg uucgaaacca ucccacguaa 60
aaaacuaagg aga                                                    73

<210> 9
<211> 61
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 9
gaauuucaca gcuuuucugu gagagagguu cgcgaacucc cucuauaaaa aacuaaggca 60
a                                                                 61

<210> 10
<211> 79
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 10
uuaauuaacu aacuguuuaa uguuuucuug uaauaagaca guucgcaauc cauccugucu 60
auaaacaaaa ccagggcaa                                              79

<210> 11
<211> 79
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 11
uauauauuau auaaugacua ggaaaaauaa uauauaagac aguucgaaag ccuccugucu 60
uuaaauaaaa cuacggugu                                              79

<210> 12
<211> 59
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 12
aaaauccaau guaauuuggu agagguucgu aaccaucccu cuauaaaaaa cuaagggcu  59

<210> 13
<211> 79
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 13
auaauaucau auuuuagaau auaaaaaaau aaauauggac aguucguaac cauccugucc 60
cuaaauaaaa cuauggagg                                              79

<210> 14
<211> 57
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 14
aaaaucgaga auuucucgga cugguucgga aacuucccag aauaaaaacu aaguauc    57

<210> 15
<211> 74
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 15
uuccauauua gaaugugaac uguugcaauu guaaccaagg uucaucaacc aucccuugua 60
aaaaacucgg agaa                                                   74

<210> 16
<211> 61
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 16
uauaaucaag acgcucgucu uggacugguu cggaaacuuc ccagaauaaa aacuaaguau 60
c                                                                 61

<210> 17
<211> 73
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 17
ccuucugcua gugugaauag uugagacugu gucuccggag uucguaaccu ccuccgucac 60
aaaacuagga aug                                                    73

<210> 18
<211> 76
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 18
auaugagaaa auagcauguu ggcaaaauug ccacacgugg uucauucaua ccaucccacg 60
uaaaaaacua ggagga                                                 76

<210> 19
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 19
aaaaucggca aucgugccgg acugguucgg aaaaucccag aaaaaaaacc aacgugug   58

<210> 20
<211> 75
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 20
acgaauuaau ugauuguguu ucugagacuu aauaauagcg guucgucaac caucccgcuu 60
aaaaaacuag gagau                                                  75

<210> 21
<211> 75
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 21
cgugcuacga uuauauucgc uuuguuucaa ucaacacgug guucguaacc aucccacguu 60
aaaaaacuag gagga                                                  75

<210> 22
<211> 73
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 22
caucacauac aguuugaccu aauuaggcga gcuggccugg uucguaaacu ucccaggaua 60
aaaaccaaga acu                                                    73

<210> 23
<211> 75
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 23
ccuucgauua uacuaaucua augugauuuu acucaccgug guucguaacc aucccacgca 60
aaaaaacuag gaagg                                                  75

<210> 24
<211> 62
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 24
gaauucugca cuacugcagg agagguucgc gauuuaaauc ccucuauaaa aaacuaagga 60
ga                                                                62

<210> 25
<211> 72
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 25
uaauaaaaca cgugcauaau cgaguauuuc ucggacuggu ucgaaaacuu cccagaauaa 60
aaacuaagug ac                                                     72

<210> 26
<211> 62
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 26
ucgcagugag caacaaaaug cucaccuggg ucgcaguaac cccaguuaac aaacaaggga 60
gg                                                                62

<210> 27
<211> 73
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 27
cacagauacc gccgcuuaua uuacaaucgc cgcccguggu ucgaaaaccu cccacauuaa 60
aaaacuaagg aaa                                                    73

<210> 28
<211> 75
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 28
uugccuguau aauccgcauc uuuacugucc aacuucgcgg uucgcaaacc ucccgcguua 60
ccaaaacuag gauuc                                                  75

<210> 29
<211> 75
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 29
uugccuguau aauccgcguc uuuacugucc aacuucgcgg uucgaaaacc ucccgcguca 60
ccaaaacuag gauuc                                                  75

<210> 30
<211> 72
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 30
acagauaccg ccgcuuauau uacaaucgcc gccccguggu ucgaaaaccu cccacacuaa 60
aaacuaagga aa                                                     72

<210> 31
<211> 74
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 31
ugcuaaaaua gaacuucccc acuagaauaa ccccccguag uucgcaaacc uccuacaaua 60
aaaaacuagg uaaa                                                   74

<210> 32
<211> 95
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 32
aacgacguuu aaacaagccu acuguuuucu uuucuaagug guucguaacc cucccacuug 60
aacaacaaca auuguucgaa acaaaacuag gaaaa                            95

<210> 33
<211> 59
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 33
aaaauccgug cgauaugcgg gagagguucu acguacaccc ucuauaaaaa cuaaggacg  59

<210> 34
<211> 62
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 34
caauuccgua cgcuuguacg ggagagguuu cuagcaaaac ccucuauaaa aaacuaggga 60
cg                                                                62

<210> 35
<211> 64
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 35
uguacaacaa acauaauuuu guuagagguu cuuagcuuca acccucuaua aaaaacuaag 60
gaca                                                              64

<210> 36
<211> 64
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 36
ucuaaguucc gugcaaaaua auaacagagg uuccuagccg aaaccucuau aaaaacuaga 60
caug                                                              64

<210> 37
<211> 74
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 37
agaugaauuu uaaguaaaau aguauaguua auuuuggcgg uuucuaaaca cccgcuuuaa 60
caaaauuuag gagg                                                   74

<210> 38
<211> 71
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 38
uauucuauuc aucguacaua aaugaauauc agagguuucu agcugaaacc cucuauaaaa 60
aacuagacau u                                                      71

<210> 39
<211> 74
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 39
caauacagag aauuguuaaa gaaauuuuua auaaguagau gugcuagcaa aaccaucuuu 60
aaaaacuaga cuug                                                   74

<210> 40
<211> 72
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 40
uuuuaaacuu ugugaaucag acuacccuuu aauuaauaag uaacuagaca accuuauaaa 60
aaacuaggag ga                                                     72

<210> 41
<211> 24
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 41
rguucrracy uccyaaaacy argr                                        24

<210> 42
<211> 29
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 42
agarguyaur accyacuaaa aaacuarrr                                   29

<210> 43
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 43
rguucrracy uccyaaaaac yargr                                       25

<210> 44
<211> 29
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 44
agarguyuar accyucuaaa aaacuarrr                                   29

<210> 45
<211> 106
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 45
ggcagaagug aaaaaauuga agaaaauccg ugcgauaugc gggagagguu cuagcuacac 60
ccucuauaaa aaacuaagga cgagcuguau ccuuggauac ggccuu                106

<210> 46
<211> 51
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 46
ggccgugcga uaugcgggag agguucuagc uacacccuca uaaaaaacua a          51

<210> 47
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 47
ggagagguuc uagcuacacc cucuauaaaa aacuaa                           36

<210> 48
<211> 81
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 48
ggccgugcga uaugcgggag agguucuagc uacacccucu auaaaaaacu aaggacgagc 60
uguauccuug gauacggccu u                                           81

<210> 49
<211> 82
<212> RNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence; note =
      synthetic construct

<400> 49
aauccgugcg auaugcggga gagguucuag cuacacccuc uauaaaaaac uaaggacgag 60
cuguauccuu ggauacggcc uu                                          82
