
                                SEQUENCE LISTING

<110> CLEGG, Stephanie J.
            DOBRZYNSKI, Eric
            ELLIS, Jonathan H.
           GERMASCHEWSKI, Volker
           GODILLOT, A. Paul
           JONAK, Zdenka L.
           LEWIS, Alan P.
           WHITE, John R.

<120> NOVEL COMPOUNDS
  

<130> PU62421


<150> 60/912,229          
<151> 2007-04-17  

<150> 61/044,132          
<151> 2008-04-11  

<160> 64

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 357
<212> DNA
<213> Murine

<400> 1
caggtccagt tgcagcagtc tggagctgaa ctggtaaggc ctgggacttc agtgacgata 60
tcctgtaagg cttctggcta caccttcact aactactgga tagtttgggt caaacagagg 120
cctggacatg gacttgagtg gattggagat ctttactctg gaggtggtta tactttctac 180
agtgaaaatt tcaaggggaa ggccacactg actgcagaca catcctccag cactgcctac 240
atgcacctca ttagcctgac atctgaggac tctgctgtct atttctgtgc aagatcgggt 300
tacgacagaa cctggtttgc tcactggggc caagggtctc tggtcactgt ctctgca    357

<210> 2
<211> 119
<212> PRT
<213> Murine

<400> 2
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
 1               5                  10                  15      
Ser Val Thr Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Ser Leu Val Thr Val Ser Ala
        115                 


<210> 3
<211> 324
<212> DNA
<213> Murine

<400> 3
gacatcaaga tgacccagtc tccatcctcc atgtctgcat cgctgggaga gagagtcact 60
atcacttgtc aggcgagtca ggacattgaa agctatttaa gctggtatca gcagaaacca 120
tggaaatctc ctaagaccct gatctattac gctacaaggt tggcagatgg ggtcccatca 180
agattcagtg gcagtggatc tggtcaagat tattctctaa ccatcagcag cctggagtct 240
gacgatacag caacttatta ctgtctacaa catggtgaga gccctcccac gttcggtgct 300
gggaccaagc tggagctgaa acgg                                        324

<210> 4
<211> 108
<212> PRT
<213> Murine

<400> 4
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg
            100                 105             


<210> 5
<211> 357
<212> DNA
<213> Murine

<400> 5
gagttccagc tgcagcagtc tggacctgag ctggtgaagc ctggcgcttc agtgaagata 60
tcctgcaagg cttctggtta ctcattcact gactacaaca tgaactgggt gaagcagagc 120
aatggaaaga gccttgagtg gattggagta attaatccta agtatggtac tactagttac 180
aatcagaagt tcaagggcaa ggccacgttg actgtagacc aatcctccaa cacagcctac 240
atgcagctca gcagcctgac atctgaggac tctgcagtct atcactgtgc aagaggaatg 300
ggactcctct ttggtatgga ctactggggc caaggaacct ctgtcaccgt ctcctca    357

<210> 6
<211> 119
<212> PRT
<213> Murine

<400> 6
Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Asn Pro Lys Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr His Cys
                85                  90                  95      
Ala Arg Gly Met Gly Leu Leu Phe Gly Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser
        115                 


<210> 7
<211> 342
<212> DNA
<213> Murine

<400> 7
gacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact 60
atgagctgca agtccagtca gagtctgtta aacagtggaa atcaraagaa ctacttggcc 120
tggtaccagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg 180
aaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc 240
atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagtttt 300
ccgtgcacgt tcggaggggg gaccaagctg gaaataaaac gg                    342

<210> 8
<211> 114
<212> PRT
<213> Murine

<400> 8
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Lys Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
                85                  90                  95      
Asp His Ser Phe Pro Cys Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 9
<211> 354
<212> DNA
<213> Murine

<400> 9
gaggtccagc tgcagcagtc tggacctgaa ctggagaagc ctggcgcttc agtgaagata 60
tcctgcaagg cttctggtta ctctttcact gtctacggca tgaactgggt gagacagagc 120
aatggaaaga gccttgaatg gattggaaat tttgatcctt actttagtgt cacttcctac 180
aaccagaagt tccaggacaa ggccacattg actgtagaca aatcctccag cacagcctac 240
atgcagctca agaacctcac atctgaagac tctgcagtct atttctgtgc aagagggagc 300
tgggaaacca tttttgctta ctggggccaa gggactctgg tcactgtctc tgca       354

<210> 10
<211> 118
<212> PRT
<213> Murine

<400> 10
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Val Tyr
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Phe Asp Pro Tyr Phe Ser Val Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Lys Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Ser Trp Glu Thr Ile Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ala
        115             


<210> 11
<211> 1347
<212> DNA
<213> Murine

<400> 11
caggtgcagc tcgtgcagag cggcgccgaa gtgaagaagc ccggggccag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc aactactgga tcgtgtgggt caggcaggcc 120
cccggccagg gactggagtg gatgggcgac ctgtatagcg gcggcggcta caccttctac 180
agcgagaact tcaagggcag ggtgaccatg accagggaca ccagcaccag caccgtgtac 240
atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggagcggc 300
tacgacagga cttggtttgc tcactggggc cagggcacac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> 12
<211> 111
<212> PRT
<213> Murine

<400> 12
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
 1               5                  10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
                85                  90                  95      
His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln Pro Lys
            100                 105                 110     


<210> 13
<211> 5
<212> PRT
<213> Murine

<400> 13
Asn Tyr Trp Ile Val
 1               5  


<210> 14
<211> 17
<212> PRT
<213> Murine

<400> 14
Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe Lys
 1               5                  10                  15      
Gly
    


<210> 15
<211> 10
<212> PRT
<213> Murine

<400> 15
Ser Gly Tyr Asp Arg Thr Trp Phe Ala His
 1               5                  10  


<210> 16
<211> 11
<212> PRT
<213> Murine

<400> 16
Gln Ala Ser Gln Asp Ile Glu Ser Tyr Leu Ser
 1               5                  10      


<210> 17
<211> 7
<212> PRT
<213> Murine

<400> 17
Tyr Ala Thr Arg Leu Ala Asp
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Protein

<400> 18
Leu Gln His Gly Glu Ser Pro Pro Thr
 1               5                  


<210> 19
<211> 5
<212> PRT
<213> Murine

<400> 19
Asp Tyr Asn Met Asn
 1               5  


<210> 20
<211> 17
<212> PRT
<213> Murine

<400> 20
Val Ile Asn Pro Lys Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 21
<211> 10
<212> PRT
<213> Murine

<400> 21
Gly Met Gly Leu Leu Phe Gly Met Asp Tyr
 1               5                  10  


<210> 22
<211> 17
<212> PRT
<213> Murine

<400> 22
Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 23
<211> 7
<212> PRT
<213> Murine

<400> 23
Gly Ala Ser Thr Arg Lys Ser
 1               5          


<210> 24
<211> 9
<212> PRT
<213> Murine

<400> 24
Gln Asn Asp His Ser Phe Pro Cys Thr
 1               5                  


<210> 25
<211> 5
<212> PRT
<213> Murine

<400> 25
Val Tyr Gly Met Asn
 1               5  


<210> 26
<211> 17
<212> PRT
<213> Murine

<400> 26
Asn Phe Asp Pro Tyr Phe Ser Val Thr Ser Tyr Asn Gln Lys Phe Gln
 1               5                  10                  15      
Asp
    


<210> 27
<211> 9
<212> PRT
<213> Murine

<400> 27
Gly Ser Trp Glu Thr Ile Phe Ala Tyr
 1               5                  


<210> 28
<211> 14
<212> PRT
<213> Murine

<400> 28
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn
 1               5                  10                  


<210> 29
<211> 7
<212> PRT
<213> Murine

<400> 29
Gly Thr Asn Asn Arg Ala Pro
 1               5          


<210> 30
<211> 8
<212> PRT
<213> Murine

<400> 30
Ala Leu Trp Tyr Ser Asn His Val
 1               5              


<210> 31
<211> 15
<212> DNA
<213> Murine

<400> 31
aactactgga tagtt                                                  15

<210> 32
<211> 51
<212> DNA
<213> Murine

<400> 32
gatctttact ctggaggtgg ttatactttc tacagtgaaa atttcaaggg g          51

<210> 33
<211> 30
<212> DNA
<213> Murine

<400> 33
tcgggttacg acagaacctg gtttgctcac                                  30

<210> 34
<211> 33
<212> DNA
<213> Murine

<400> 34
caggcgagtc aggacattga aagctattta agc                              33

<210> 35
<211> 21
<212> DNA
<213> Murine

<400> 35
tacgctacaa ggttggcaga t                                           21

<210> 36
<211> 27
<212> DNA
<213> Murine

<400> 36
ctacaacatg gtgagagccc tcccacg                                     27

<210> 37
<211> 15
<212> DNA
<213> Murine

<400> 37
gactacaaca tgaac                                                  15

<210> 38
<211> 51
<212> DNA
<213> Murine

<400> 38
gtaattaatc ctaagtatgg tactactagt tacaatcaga agttcaaggg c          51

<210> 39
<211> 30
<212> DNA
<213> Murine

<400> 39
ggaatgggac tcctctttgg tatggactac                                  30

<210> 40
<211> 51
<212> DNA
<213> Murine

<400> 40
aagtccagtc agagtctgtt aaacagtgga aatcaaaaga actacttggc c          51

<210> 41
<211> 21
<212> DNA
<213> Murine

<400> 41
ggggcatcca ctaggaaatc t                                           21

<210> 42
<211> 27
<212> DNA
<213> Murine

<400> 42
cagaatgatc atagttttcc gtgcacg                                     27

<210> 43
<211> 15
<212> DNA
<213> Murine

<400> 43
gtctacggca tgaac                                                  15

<210> 44
<211> 51
<212> DNA
<213> Murine

<400> 44
aattttgatc cttactttag tgtcacttcc tacaaccaga agttccagga c          51

<210> 45
<211> 27
<212> DNA
<213> Murine

<400> 45
gggagctggg aaaccatttt tgcttac                                     27

<210> 46
<211> 449
<212> PRT
<213> Murine

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 47
<211> 642
<212> DNA
<213> Murine

<400> 47
gatatccaga tgacccagag ccctagctcc ctcagcgcat cagtcggcga cagagtgaca 60
atcacctgcc aggcatccca ggacatcgag tcttacctga gctggtacca gcagaagccc 120
ggaaaggccc caaagctcct gatctactac gccactcggc tggcagacgg cgtgcctagc 180
aggttctccg gctcagggtc tgggacagac ttcaccctga ccatcagctc actgcagccc 240
gaggatttcg ccacctacta ctgtctgcag cacggagaga gccccccaac ctttggccag 300
ggaaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 48
<211> 214
<212> PRT
<213> Murine

<400> 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 49
<211> 15
<212> PRT
<213> Murine

<400> 49
Leu Ala Thr Glu Leu Arg Ser Gln Ser Leu Gln Thr Leu Gln Gly
 1               5                  10                  15  


<210> 50
<211> 15
<212> PRT
<213> Murine

<400> 50
Ser Ala Lys Glu Leu Arg Ser Gln Ser Ile Lys Thr Tyr Ser Lys
 1               5                  10                  15  


<210> 51
<211> 14
<212> PRT
<213> Murine

<400> 51
Leu Arg Glu Leu Arg Ser Val Ser Leu Gln Thr Thr Gln Gly
 1               5                  10                  


<210> 52
<211> 14
<212> PRT
<213> Murine

<400> 52
Ser Pro Gly Pro His Ser Ala Gln Thr Glu Val Ile Ala Thr
 1               5                  10                  


<210> 53
<211> 14
<212> PRT
<213> Murine

<400> 53
Glu Ser Gly Pro His Ser Ala Asn Thr Glu Ile Ile Val Lys
 1               5                  10                  


<210> 54
<211> 14
<212> PRT
<213> Murine

<400> 54
Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro
 1               5                  10                  


<210> 55
<211> 1347
<212> DNA
<213> Murine

<400> 55
caggtccagt tgcagcagtc tggagctgaa ctggtaaggc ctgggacttc agtgacgata 60
tcctgtaagg cttctggcta caccttcact aactactgga tagtttgggt caaacagagg 120
cctggacatg gacttgagtg gattggagat ctttactctg gaggtggtta tactttctac 180
agtgaaaatt tcaaggggaa ggccacactg actgcagaca catcctccag cactgcctac 240
atgcacctca ttagcctgac atctgaggac tctgctgtct atttctgtgc aagatcgggt 300
tacgacagaa cctggtttgc tcactggggc caagggtcac tagtgaccgt gtccagcgcc 360
agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc 420
acagccgccc tgggctgcct ggtgaaggac tacttccccg aaccggtgac cgtgtcctgg 480
aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac 600
atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag 660
agctgtgaca agacccacac ctgccccccc tgccctgccc ccgagctgct gggaggcccc 720
agcgtgttcc tgttcccccc caagcctaag gacaccctga tgatcagcag aacccccgag 780
gtgacctgtg tggtggtgga tgtgagccac gaggaccctg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaacagc 900
acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag 960
tacaagtgta aggtgtccaa caaggccctg cctgccccta tcgagaaaac catcagcaag 1020
gccaagggcc agcccagaga gccccaggtg tacaccctgc cccctagcag agatgagctg 1080
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc 1140
gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg 1200
gacagcgatg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag 1260
cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaatca ctacacccag 1320
aagagcctga gcctgtcccc tggcaag                                     1347

<210> 56
<211> 449
<212> PRT
<213> Murine

<400> 56
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
 1               5                  10                  15      
Ser Val Thr Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 57
<211> 642
<212> DNA
<213> Murine

<400> 57
gacatcaaga tgacccagtc tccatcctcc atgtctgcat cgctgggaga gagagtcact 60
atcacttgtc aggcgagtca ggacattgaa agctatttaa gctggtatca gcagaaacca 120
tggaaatctc ctaagaccct gatctattac gctacaaggt tggcagatgg ggtcccatca 180
agattcagtg gcagtggatc tggtcaagat tattctctaa ccatcagcag cctggagtct 240
gacgatacag caacttatta ctgtctacaa catggtgaga gccctcccac gttcggtgct 300
gggaccaagc tggagctgaa acgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 58
<211> 214
<212> PRT
<213> Murine

<400> 58
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 59
<211> 642
<212> DNA
<213> Murine

<400> 59
gatatccaga tgacccagag ccctagctcc ctcagcgcat cagtcggcga cagagtgaca 60
atcacctgcc aggcatccca ggacatcgag tcttacctga gctggtacca gcagaagccc 120
ggaaaggccc caaagctcct gatctactac gccactcggc tggcagacgg cgtgcctagc 180
aggttctccg gctcagggtc tgggacagac ttcaccttca ccatcagctc actgcagccc 240
gaggatatcg ccacctacta ctgtctgcag cacggagaga gccccccaac ctttggccag 300
ggaaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 60
<211> 214
<212> PRT
<213> Murine

<400> 60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 61
<211> 642
<212> DNA
<213> Murine

<400> 61
gatatccaga tgacccagag ccctagctcc ctcagcgcat cagtcggcga cagagtgaca 60
atcacctgcc aggcatccca ggacatcgag tcttacctga gctggtacca gcagaagccc 120
ggaaaggccc caaagctcct gatctactac gccactcggc tggcagacgg cgtgcctagc 180
aggttctccg gctcagggtc tgggcaggac tacaccctga ccatcagctc actgcagccc 240
gaggatttcg ccacctacta ctgtctgcag cacggagaga gccccccaac ctttggccag 300
ggaaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 62
<211> 214
<212> PRT
<213> Murine

<400> 62
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 63
<211> 642
<212> DNA
<213> Murine

<400> 63
gagatcgtgc tgacccagtc tcccgccacc ctgtcactgt ctcccggcga aagggcaacc 60
ctgagctgcc aggccagcca ggacatcgag agctacctga gctggtacca gcagaagccc 120
ggccaggccc ccaggctgct gatctactac gccaccaggc tggccgacgg cattcccgcc 180
aggttcagcg gaagcggcag cggcaccgac ttcactctga ccatcagcag cctggagccc 240
gaggacttcg ccgtgtacta ctgcctgcag cacggcgaga gccctcccac cttcggccag 300
ggcaccaagc tcgagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc 360
agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag 480
gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc 600
ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                    642

<210> 64
<211> 214
<212> PRT
<213> Murine

<400> 64
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 

