
                                SEQUENCE LISTING

<110> Johns, Roger
      Tao, Feng

<120> BIOLOGICAL AGENTS ACTIVE IN CENTRAL
  NERVOUS SYSTEM
  
  

<130> 201107.00016

<150> 60/925322           
<151> 2007-04-19  

<150> 60/925325           
<151> 2007-04-19  

<160> 13

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 870
<212> PRT
<213> Homo sapiens

<400> 1
Met Phe Phe Ala Cys Tyr Cys Ala Leu Arg Thr Asn Val Lys Lys Tyr
 1               5                  10                  15
Arg Tyr Gln Asp Glu Asp Ala Pro His Asp His Ser Leu Pro Arg Leu
            20                  25                  30
Thr His Glu Val Arg Gly Pro Glu Leu Val His Val Ser Glu Lys Asn
        35                  40                  45
Leu Ser Gln Ile Glu Asn Val His Gly Tyr Val Leu Gln Ser His Ile
    50                  55                  60
Ser Pro Leu Lys Ala Ser Pro Ala Pro Ile Ile Val Asn Thr Asp Thr
65                  70                  75                  80
Leu Asp Thr Ile Pro Tyr Val Asn Gly Thr Glu Ile Glu Tyr Glu Phe
                85                  90                  95
Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile
            100                 105                 110
Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Gly Ile Phe
        115                 120                 125
Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Glu Asp Gly Arg Leu
    130                 135                 140
Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Ser Glu
145                 150                 155                 160
Val Ser His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile
                165                 170                 175
Val Arg Leu Tyr Val Arg Arg Arg Arg Pro Ile Leu Glu Thr Val Val
            180                 185                 190
Glu Ile Lys Leu Phe Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala
        195                 200                 205
Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val
    210                 215                 220
Thr Lys Ile Ile Asp Gly Gly Ala Ala Gln Lys Asp Gly Arg Leu Gln
225                 230                 235                 240
Val Gly Asp Arg Leu Leu Met Val Asn Asn Tyr Ser Leu Glu Glu Val
                245                 250                 255
Thr His Glu Glu Ala Val Ala Ile Leu Lys Asn Thr Ser Glu Val Val
            260                 265                 270
Tyr Leu Lys Val Gly Lys Pro Thr Thr Ile Tyr Met Thr Asp Pro Tyr
        275                 280                 285
Gly Pro Pro Asp Ile Thr His Ser Tyr Ser Pro Pro Met Glu Asn His
    290                 295                 300
Leu Leu Ser Gly Asn Asn Gly Thr Leu Glu Tyr Lys Thr Ser Leu Pro
305                 310                 315                 320
Pro Ile Ser Pro Gly Arg Tyr Ser Pro Ile Pro Lys His Met Leu Val
                325                 330                 335
Asp Asp Asp Tyr Thr Arg Pro Pro Glu Pro Val Tyr Ser Thr Val Asn
            340                 345                 350
Lys Leu Cys Asp Lys Pro Ala Ser Pro Arg His Tyr Ser Pro Val Glu
        355                 360                 365
Cys Asp Lys Ser Phe Leu Leu Ser Ala Pro Tyr Ser His Tyr His Leu
    370                 375                 380
Gly Leu Leu Pro Asp Ser Glu Met Thr Ser His Ser Gln His Ser Thr
385                 390                 395                 400
Ala Thr Arg Gln Pro Ser Met Thr Leu Gln Arg Ala Val Ser Leu Glu
                405                 410                 415
Gly Glu Pro Arg Lys Val Val Leu His Lys Gly Ser Thr Gly Leu Gly
            420                 425                 430
Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Val Ser Phe
        435                 440                 445
Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Gln Arg Gly
    450                 455                 460
Asp Gln Ile Leu Ser Val Asn Gly Ile Asp Leu Arg Gly Ala Ser His
465                 470                 475                 480
Glu Gln Ala Ala Ala Ala Leu Lys Gly Ala Gly Gln Thr Val Thr Ile
                485                 490                 495
Ile Ala Gln Tyr Gln Pro Glu Asp Tyr Ala Arg Phe Glu Ala Lys Ile
            500                 505                 510
His Asp Leu Arg Glu Gln Met Met Asn His Ser Met Ser Ser Gly Ser
        515                 520                 525
Gly Ser Leu Arg Thr Asn Gln Lys Arg Ser Leu Tyr Val Arg Ala Met
    530                 535                 540
Phe Asp Tyr Asp Lys Ser Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu
545                 550                 555                 560
Ser Phe Lys Tyr Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp
                565                 570                 575
Glu Trp Trp Gln Ala Arg Arg Val Met Leu Glu Gly Asp Ser Glu Glu
            580                 585                 590
Met Gly Val Ile Pro Ser Lys Arg Arg Val Glu Arg Lys Glu Arg Ala
        595                 600                 605
Arg Leu Lys Thr Val Lys Phe Asn Ala Lys Pro Gly Val Ile Asp Ser
    610                 615                 620
Lys Gly Ser Phe Asn Asp Lys Arg Lys Lys Ser Phe Ile Phe Ser Arg
625                 630                 635                 640
Lys Phe Pro Phe Tyr Lys Asn Lys Glu Gln Ser Glu Gln Glu Thr Ser
                645                 650                 655
Asp Pro Glu Arg Gly Gln Glu Asp Leu Ile Leu Ser Tyr Glu Pro Val
            660                 665                 670
Thr Arg Gln Glu Ile Asn Tyr Thr Arg Pro Val Ile Ile Leu Gly Pro
        675                 680                 685
Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser Glu Phe Pro Asp Lys
    690                 695                 700
Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Asp Tyr Glu
705                 710                 715                 720
Val Asp Gly Arg Asp Tyr His Phe Val Ile Ser Arg Glu Gln Met Glu
                725                 730                 735
Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Asp
            740                 745                 750
Asn Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Phe Val Ala Glu Arg
        755                 760                 765
Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu
    770                 775                 780
Gln Val Ala Gln Leu Tyr Pro Ile Ala Ile Phe Ile Lys Pro Arg Ser
785                 790                 795                 800
Leu Glu Pro Leu Met Glu Met Asn Lys Arg Leu Thr Glu Glu Gln Ala
                805                 810                 815
Lys Lys Thr Tyr Asp Arg Ala Ile Lys Leu Glu Gln Glu Phe Gly Glu
            820                 825                 830
Tyr Phe Thr Ala Ile Val Gln Gly Asp Thr Leu Glu Asp Ile Tyr Asn
        835                 840                 845
Gln Cys Lys Leu Val Ile Glu Glu Gln Ser Gly Pro Phe Ile Trp Ile
    850                 855                 860
Pro Ser Lys Glu Lys Leu
865                 870

<210> 2
<211> 77
<212> PRT
<213> Homo sapiens

<400> 2
Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile
 1               5                  10                  15
Gly Asp Asp Pro Gly Ile Phe Ile Thr Lys Ile Ile Pro Gly Gly Ala
            20                  25                  30
Ala Ala Glu Asp Gly Arg Leu Arg Val Asn Asp Cys Ile Leu Arg Val
        35                  40                  45
Asn Glu Val Asp Val Ser Glu Val Ser His Ser Lys Ala Val Glu Ala
    50                  55                  60
Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Arg
65                  70                  75

<210> 3
<211> 86
<212> PRT
<213> Homo sapiens

<400> 3
Val Val Glu Ile Lys Leu Phe Lys Gly Pro Lys Gly Leu Gly Phe Ser
 1               5                  10                  15
Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile
            20                  25                  30
Tyr Val Thr Lys Ile Ile Asp Gly Gly Ala Ala Gln Lys Asp Gly Arg
        35                  40                  45
Leu Gln Val Gly Asp Arg Leu Leu Met Val Asn Asn Tyr Ser Leu Glu
    50                  55                  60
Glu Val Thr His Glu Glu Ala Val Ala Ile Leu Lys Asn Thr Ser Glu
65                  70                  75                  80
Val Val Tyr Leu Lys Val
                85

<210> 4
<211> 81
<212> PRT
<213> Homo sapiens

<400> 4
Pro Arg Lys Val Val Leu His Lys Gly Ser Thr Gly Leu Gly Phe Asn
 1               5                  10                  15
Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Val Ser Phe Ile Leu
            20                  25                  30
Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Gln Arg Gly Asp Gln
        35                  40                  45
Ile Leu Ser Val Asn Gly Ile Asp Leu Arg Gly Ala Ser His Glu Gln
    50                  55                  60
Ala Ala Ala Ala Leu Lys Gly Ala Gly Gln Thr Val Thr Ile Ile Ala
65                  70                  75                  80
Gln


<210> 5
<211> 767
<212> PRT
<213> Homo sapiens

<400> 5
Met Ser Gln Arg Pro Arg Ala Pro Arg Ser Ala Leu Trp Leu Leu Ala
 1               5                  10                  15
Pro Pro Leu Leu Arg Trp Ala Pro Pro Leu Leu Thr Val Leu His Ser
            20                  25                  30
Asp Leu Phe Gln Ala Leu Leu Asp Ile Leu Asp Tyr Tyr Glu Ala Ser
        35                  40                  45
Leu Ser Glu Ser Gln Lys Tyr Arg Tyr Gln Asp Glu Asp Thr Pro Pro
    50                  55                  60
Leu Glu His Ser Pro Ala His Leu Pro Asn Gln Ala Asn Ser Pro Pro
65                  70                  75                  80
Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro Gly Tyr Glu Leu Gln
                85                  90                  95
Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr Leu Glu
            100                 105                 110
Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn
        115                 120                 125
Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile Ile Pro
    130                 135                 140
Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp Ser Ile
145                 150                 155                 160
Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser Ala Ala
                165                 170                 175
Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Met
            180                 185                 190
Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile Lys
        195                 200                 205
Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln
    210                 215                 220
His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly
225                 230                 235                 240
Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu
                245                 250                 255
Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala Val
            260                 265                 270
Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala Lys
        275                 280                 285
Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp Ile Thr
    290                 295                 300
Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser Ser Tyr
305                 310                 315                 320
Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro Arg Arg
                325                 330                 335
Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile Pro Arg
            340                 345                 350
Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe
        355                 360                 365
Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile
    370                 375                 380
Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp
385                 390                 395                 400
Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu
                405                 410                 415
Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile
            420                 425                 430
Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His
        435                 440                 445
Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly Thr Ala
    450                 455                 460
Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala Leu Phe
465                 470                 475                 480
Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala Leu Ser
                485                 490                 495
Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp Glu Glu
            500                 505                 510
Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp Asp Ile
        515                 520                 525
Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp Ser Arg
    530                 535                 540
Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly Arg Glu
545                 550                 555                 560
Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val His Tyr
                565                 570                 575
Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala Asn Asp
            580                 585                 590
Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His
        595                 600                 605
Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His
    610                 615                 620
Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala His Lys
625                 630                 635                 640
Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr Ser Val
                645                 650                 655
Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile Leu Asp
            660                 665                 670
Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu His Pro
        675                 680                 685
Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu Glu Ile
    690                 695                 700
Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp Arg Ala
705                 710                 715                 720
Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile Val Glu
                725                 730                 735
Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val Ile Glu
            740                 745                 750
Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg Leu
        755                 760                 765

<210> 6
<211> 84
<212> PRT
<213> Homo sapiens

<400> 6
Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala
 1               5                  10                  15
Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile
            20                  25                  30
Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg
        35                  40                  45
Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val
    50                  55                  60
Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val
65                  70                  75                  80
Arg Leu Tyr Val


<210> 7
<211> 90
<212> PRT
<213> Homo sapiens

<400> 7
Val Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser
 1               5                  10                  15
Ile Ala Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile
            20                  25                  30
Tyr Val Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg
        35                  40                  45
Leu Gln Ile Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu
    50                  55                  60
Asp Val Met His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp
65                  70                  75                  80
Val Val Tyr Leu Lys Val Ala Lys Pro Ser
                85                  90

<210> 8
<211> 81
<212> PRT
<213> Homo sapiens

<400> 8
Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe Asn
 1               5                  10                  15
Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu
            20                  25                  30
Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Gln
        35                  40                  45
Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu Gln
    50                  55                  60
Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile Ala
65                  70                  75                  80
Gln


<210> 9
<211> 11
<212> PRT
<213> Homo sapiens

<400> 9
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10

<210> 10
<211> 415
<212> PRT
<213> Homo sapiens

<400> 10
Met Phe Ala Asp Leu Asp Tyr Asp Ile Glu Glu Asp Lys Leu Gly Ile
 1               5                  10                  15
Pro Thr Val Pro Gly Lys Val Thr Leu Gln Lys Asp Ala Gln Asn Leu
            20                  25                  30
Ile Gly Ile Ser Ile Gly Gly Gly Ala Gln Tyr Cys Pro Cys Leu Tyr
        35                  40                  45
Ile Val Gln Val Phe Asp Asn Thr Pro Ala Ala Leu Asp Gly Thr Val
    50                  55                  60
Ala Ala Gly Asp Glu Ile Thr Gly Val Asn Gly Arg Ser Ile Lys Gly
65                  70                  75                  80
Lys Thr Lys Val Glu Val Ala Lys Met Ile Gln Glu Val Lys Gly Glu
                85                  90                  95
Val Thr Ile His Tyr Asn Lys Leu Gln Ala Asp Pro Lys Gln Gly Met
            100                 105                 110
Ser Leu Asp Ile Val Leu Lys Lys Val Lys His Arg Leu Val Glu Asn
        115                 120                 125
Met Ser Ser Gly Thr Ala Asp Ala Leu Gly Leu Ser Arg Ala Ile Leu
    130                 135                 140
Cys Asn Asp Gly Leu Val Lys Arg Leu Glu Glu Leu Glu Arg Thr Ala
145                 150                 155                 160
Glu Leu Tyr Lys Gly Met Thr Glu His Thr Lys Asn Leu Leu Arg Ala
                165                 170                 175
Phe Tyr Glu Leu Ser Gln Thr His Arg Ala Phe Gly Asp Val Phe Ser
            180                 185                 190
Val Ile Gly Val Arg Glu Pro Gln Pro Ala Ala Ser Glu Ala Phe Val
        195                 200                 205
Lys Phe Ala Asp Ala His Arg Ser Ile Glu Lys Phe Gly Ile Arg Leu
    210                 215                 220
Leu Lys Thr Ile Lys Pro Met Leu Thr Asp Leu Asn Thr Tyr Leu Asn
225                 230                 235                 240
Lys Ala Ile Pro Asp Thr Arg Leu Thr Ile Lys Lys Tyr Leu Asp Val
                245                 250                 255
Lys Phe Glu Tyr Leu Ser Tyr Cys Leu Lys Val Lys Glu Met Asp Asp
            260                 265                 270
Glu Glu Tyr Ser Cys Ile Ala Leu Gly Glu Pro Leu Tyr Arg Val Ser
        275                 280                 285
Thr Gly Asn Tyr Glu Tyr Arg Leu Ile Leu Arg Cys Arg Gln Glu Ala
    290                 295                 300
Arg Ala Arg Phe Ser Gln Met Arg Lys Asp Val Leu Glu Lys Met Glu
305                 310                 315                 320
Leu Leu Asp Gln Lys His Val Gln Asp Ile Val Phe Gln Leu Gln Arg
                325                 330                 335
Leu Val Ser Thr Met Ser Lys Tyr Tyr Asn Asp Cys Tyr Ala Val Leu
            340                 345                 350
Arg Asp Ala Asp Val Phe Pro Ile Glu Val Asp Leu Ala His Thr Thr
        355                 360                 365
Leu Ala Tyr Gly Leu Asn Gln Glu Glu Phe Thr Asp Gly Glu Glu Glu
    370                 375                 380
Glu Glu Glu Glu Asp Thr Ala Ala Gly Glu Pro Ser Arg Asp Thr Arg
385                 390                 395                 400
Gly Ala Ala Gly Pro Leu Asp Lys Gly Gly Ser Trp Cys Asp Ser
                405                 410                 415

<210> 11
<211> 77
<212> PRT
<213> Homo sapiens

<400> 11
Val Thr Leu Gln Lys Asp Ala Gln Asn Leu Ile Gly Ile Ser Ile Gly
 1               5                  10                  15
Gly Gly Ala Gln Tyr Cys Pro Cys Leu Tyr Ile Val Gln Val Phe Asp
            20                  25                  30
Asn Thr Pro Ala Ala Leu Asp Gly Thr Val Ala Ala Gly Asp Glu Ile
        35                  40                  45
Thr Gly Val Asn Gly Arg Ser Ile Lys Gly Lys Thr Lys Val Glu Val
    50                  55                  60
Ala Lys Met Ile Gln Glu Val Lys Gly Glu Val Thr Ile
65                  70                  75

<210> 12
<211> 2042
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Glu Ala Ile Asp Lys Asn Arg Ala Leu His Ala Ala Glu Arg
 1               5                  10                  15
Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala Asn Glu Asp Lys
            20                  25                  30
Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe Ser Gln Ile
        35                  40                  45
Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp Gln Val Asn Ile
    50                  55                  60
Ala Thr Ser Ala Thr Ser Asn Ile Glu Tyr Ala His Val Pro His Leu
65                  70                  75                  80
Ser Pro Ala Val Ile Pro Thr Leu Gln Asn Glu Ser Phe Leu Leu Ser
                85                  90                  95
Pro Asn Asn Gly Asn Leu Glu Ala Leu Thr Gly Pro Gly Ile Pro His
            100                 105                 110
Ile Asn Gly Lys Pro Ala Cys Asp Glu Phe Asp Gln Leu Ile Lys Asn
        115                 120                 125
Met Ala Gln Gly Arg His Val Glu Val Phe Glu Leu Leu Lys Pro Pro
    130                 135                 140
Ser Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg Ser Glu Asn Arg
145                 150                 155                 160
Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu Gly Ser Val Ala
                165                 170                 175
His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile Leu Ala Ile Asn
            180                 185                 190
Gly Gln Ala Leu Asp Gln Thr Ile Thr His Gln Gln Ala Ile Ser Ile
        195                 200                 205
Leu Gln Lys Ala Lys Asp Thr Val Gln Leu Val Ile Ala Arg Gly Ser
    210                 215                 220
Leu Pro Gln Leu Val Ser Pro Ile Val Ser Arg Ser Pro Ser Ala Ala
225                 230                 235                 240
Ser Thr Ile Ser Ala His Ser Asn Pro Val His Trp Gln His Met Glu
                245                 250                 255
Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly Phe Gly Ile Ile
            260                 265                 270
Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile Leu Pro Gly Gly
        275                 280                 285
Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp His Ile Leu Lys
    290                 295                 300
Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu Gln Val Ala Gln
305                 310                 315                 320
Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met Ile Ala Arg Gly
                325                 330                 335
Ala Ile Glu Glu Arg Thr Ala Pro Thr Ala Leu Gly Ile Thr Leu Ser
            340                 345                 350
Ser Ser Pro Thr Ser Thr Pro Glu Leu Arg Val Asp Ala Ser Thr Gln
        355                 360                 365
Lys Gly Glu Glu Ser Glu Thr Phe Asp Val Glu Leu Thr Lys Asn Val
    370                 375                 380
Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly Asp Lys Lys Leu
385                 390                 395                 400
Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys Ser Ser Ala Val
                405                 410                 415
Glu His Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile Ile Ala Val Asp
            420                 425                 430
Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala Val Glu Val Leu
        435                 440                 445
Arg His Thr Gly Gln Thr Val Leu Leu Thr Leu Met Arg Arg Gly Met
    450                 455                 460
Lys Gln Glu Ala Glu Leu Met Ser Arg Glu Asp Val Thr Lys Asp Ala
465                 470                 475                 480
Asp Leu Ser Pro Val Asn Ala Ser Ile Ile Lys Glu Asn Tyr Glu Lys
                485                 490                 495
Asp Glu Asp Phe Leu Ser Ser Thr Arg Asn Thr Asn Ile Leu Pro Thr
            500                 505                 510
Glu Glu Glu Gly Tyr Pro Leu Leu Ser Ala Glu Ile Glu Glu Ile Glu
        515                 520                 525
Asp Ala Gln Lys Gln Glu Ala Ala Leu Leu Thr Lys Trp Gln Arg Ile
    530                 535                 540
Met Gly Ile Asn Tyr Glu Ile Val Val Ala His Val Ser Lys Phe Ser
545                 550                 555                 560
Glu Asn Ser Gly Leu Gly Ile Ser Leu Glu Ala Thr Val Gly His His
                565                 570                 575
Phe Ile Arg Ser Val Leu Pro Glu Gly Pro Val Gly His Ser Gly Lys
            580                 585                 590
Leu Phe Ser Gly Asp Glu Leu Leu Glu Val Asn Gly Ile Thr Leu Leu
        595                 600                 605
Gly Glu Asn His Gln Asp Val Val Asn Ile Leu Lys Glu Leu Pro Ile
    610                 615                 620
Glu Val Thr Met Val Cys Cys Arg Arg Thr Val Pro Pro Thr Thr Gln
625                 630                 635                 640
Ser Glu Leu Asp Ser Leu Asp Leu Cys Asp Ile Glu Leu Thr Glu Lys
                645                 650                 655
Pro His Val Asp Leu Gly Glu Phe Ile Gly Ser Ser Glu Thr Glu Asp
            660                 665                 670
Pro Val Leu Ala Met Thr Asp Ala Gly Gln Ser Thr Glu Glu Val Gln
        675                 680                 685
Ala Pro Leu Ala Met Trp Glu Ala Gly Ile Gln His Ile Glu Leu Glu
    690                 695                 700
Lys Gly Ser Lys Gly Leu Gly Phe Ser Ile Leu Asp Tyr Gln Asp Pro
705                 710                 715                 720
Ile Asp Pro Ala Ser Thr Val Ile Ile Ile Arg Ser Leu Val Pro Gly
                725                 730                 735
Gly Ile Ala Glu Lys Asp Gly Arg Leu Leu Pro Gly Asp Arg Leu Met
            740                 745                 750
Phe Val Asn Asp Val Asn Leu Glu Asn Ser Ser Leu Glu Glu Ala Val
        755                 760                 765
Glu Ala Leu Lys Gly Ala Pro Ser Gly Thr Val Arg Ile Gly Val Ala
    770                 775                 780
Lys Pro Leu Pro Leu Ser Pro Glu Glu Gly Tyr Val Ser Ala Lys Glu
785                 790                 795                 800
Asp Ser Phe Leu Tyr Pro Pro His Ser Cys Glu Glu Ala Gly Leu Ala
                805                 810                 815
Asp Lys Pro Leu Phe Arg Ala Asp Leu Ala Leu Val Gly Thr Asn Asp
            820                 825                 830
Ala Asp Leu Val Asp Glu Ser Thr Phe Glu Ser Pro Tyr Ser Pro Glu
        835                 840                 845
Asn Asp Ser Ile Tyr Ser Thr Gln Ala Ser Ile Leu Ser Leu His Gly
    850                 855                 860
Ser Ser Cys Gly Asp Gly Leu Asn Tyr Gly Ser Ser Leu Pro Ser Ser
865                 870                 875                 880
Pro Pro Lys Asp Val Ile Glu Asn Ser Cys Asp Pro Val Leu Asp Leu
                885                 890                 895
His Met Ser Leu Glu Glu Leu Tyr Thr Gln Asn Leu Leu Gln Arg Gln
            900                 905                 910
Asp Glu Asn Thr Pro Ser Val Asp Ile Ser Met Gly Pro Ala Ser Gly
        915                 920                 925
Phe Thr Ile Asn Asp Tyr Thr Pro Ala Asn Ala Ile Glu Gln Gln Tyr
    930                 935                 940
Glu Cys Glu Asn Thr Ile Val Trp Thr Glu Ser His Leu Pro Ser Glu
945                 950                 955                 960
Val Ile Ser Ser Ala Glu Leu Pro Ser Val Leu Pro Asp Ser Ala Gly
                965                 970                 975
Lys Gly Ser Glu Tyr Leu Leu Glu Gln Ser Ser Leu Ala Cys Asn Ala
            980                 985                 990
Glu Cys Val Met Leu Gln Asn Val Ser Lys Glu Ser Phe Glu Arg Thr
        995                 1000                1005
Ile Asn Ile Ala Lys Gly Asn Ser Ser Leu Gly Met Thr Val Ser Ala
    1010                1015                1020
Asn Lys Asp Gly Leu Gly Met Ile Val Arg Ser Ile Ile His Gly Gly
1025                1030                1035                1040
Ala Ile Ser Arg Asp Gly Arg Ile Ala Ile Gly Asp Cys Ile Leu Ser
                1045                1050                1055
Ile Asn Glu Glu Ser Thr Ile Ser Val Thr Asn Ala Gln Ala Arg Ala
            1060                1065                1070
Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile Lys Ile Thr Tyr
        1075                1080                1085
Val Pro Ala Glu His Leu Glu Glu Phe Lys Ile Ser Leu Gly Gln Gln
    1090                1095                1100
Ser Gly Arg Val Met Ala Leu Asp Ile Phe Ser Ser Tyr Thr Gly Arg
1105                1110                1115                1120
Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu Gly Glu Glu Ser
                1125                1130                1135
Glu Leu Gln Asn Thr Ala Tyr Ser Asn Trp Asn Gln Pro Arg Arg Val
            1140                1145                1150
Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile Ser Ile Val Gly
        1155                1160                1165
Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu Val Met Arg Gly
    1170                1175                1180
Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala Gly Lys Asn Gly
1185                1190                1195                1200
Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp Gly Met Asp Leu
                1205                1210                1215
Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile Arg Lys Ala Gly
            1220                1225                1230
Asn Pro Val Val Phe Met Val Gln Ser Ile Ile Asn Arg Pro Arg Lys
        1235                1240                1245
Ser Pro Leu Pro Ser Leu Leu His Asn Leu Tyr Pro Lys Tyr Asn Phe
    1250                1255                1260
Ser Ser Thr Asn Pro Phe Ala Asp Ser Leu Gln Ile Asn Ala Asp Lys
1265                1270                1275                1280
Ala Pro Ser Gln Ser Glu Ser Glu Pro Glu Lys Ala Pro Leu Cys Ser
                1285                1290                1295
Val Pro Pro Pro Pro Pro Ser Ala Phe Ala Glu Met Gly Ser Asp His
            1300                1305                1310
Thr Gln Ser Ser Ala Ser Lys Ile Ser Gln Asp Val Asp Lys Glu Asp
        1315                1320                1325
Glu Phe Gly Tyr Ser Trp Lys Asn Ile Arg Glu Arg Tyr Gly Thr Leu
    1330                1335                1340
Thr Gly Glu Leu His Met Ile Glu Leu Glu Lys Gly His Ser Gly Leu
1345                1350                1355                1360
Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg Met Ser Val Phe
                1365                1370                1375
Ile Val Gly Ile Asp Pro Asn Gly Ala Ala Gly Lys Asp Gly Arg Leu
            1380                1385                1390
Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln Ile Leu Tyr Gly
        1395                1400                1405
Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys Ala Pro Ser Lys
    1410                1415                1420
Val Lys Ile Ile Phe Ile Arg Asn Lys Asp Ala Val Asn Gln Met Ala
1425                1430                1435                1440
Val Cys Pro Gly Asn Ala Val Glu Pro Leu Pro Ser Asn Ser Glu Asn
                1445                1450                1455
Leu Gln Asn Lys Glu Thr Glu Pro Thr Val Thr Thr Ser Asp Ala Ala
            1460                1465                1470
Val Asp Leu Ser Ser Phe Lys Asn Val Gln His Leu Glu Leu Pro Lys
        1475                1480                1485
Asp Gln Gly Gly Leu Gly Ile Ala Ile Ser Glu Glu Asp Thr Leu Ser
    1490                1495                1500
Gly Val Ile Ile Lys Ser Leu Thr Glu His Gly Val Ala Ala Thr Asp
1505                1510                1515                1520
Gly Arg Leu Lys Val Gly Asp Gln Ile Leu Ala Val Asp Asp Glu Ile
                1525                1530                1535
Val Val Gly Tyr Pro Ile Glu Lys Phe Ile Ser Leu Leu Lys Thr Ala
            1540                1545                1550
Lys Met Thr Val Lys Leu Thr Ile His Ala Glu Asn Pro Asp Ser Gln
        1555                1560                1565
Ala Val Pro Ser Ala Ala Gly Ala Ala Ser Gly Glu Lys Lys Asn Ser
    1570                1575                1580
Ser Gln Ser Leu Met Val Pro Gln Ser Gly Ser Pro Glu Pro Glu Ser
1585                1590                1595                1600
Ile Arg Asn Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp
                1605                1610                1615
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile
            1620                1625                1630
Ser Lys Gly Arg Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp
        1635                1640                1645
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala
    1650                1655                1660
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val
1665                1670                1675                1680
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val
                1685                1690                1695
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu
            1700                1705                1710
Ala Pro Tyr Lys Glu Glu Glu Val Cys Asp Thr Leu Thr Ile Glu Leu
        1715                1720                1725
Gln Lys Lys Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg
    1730                1735                1740
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala
1745                1750                1755                1760
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn
                1765                1770                1775
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu
            1780                1785                1790
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala
        1795                1800                1805
Gly Ser Ser Thr Ser Glu Ser Leu Glu Ser Ser Ser Lys Lys Asn Ala
    1810                1815                1820
Leu Ala Ser Glu Ile Gln Gly Leu Arg Thr Val Glu Met Lys Lys Gly
1825                1830                1835                1840
Pro Thr Asp Ser Leu Gly Ile Ser Ile Ala Gly Gly Val Gly Ser Pro
                1845                1850                1855
Leu Gly Asp Val Pro Ile Phe Ile Ala Met Met His Pro Thr Gly Val
            1860                1865                1870
Ala Ala Gln Thr Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile
        1875                1880                1885
Cys Gly Thr Ser Thr Glu Gly Met Thr His Thr Gln Ala Val Asn Leu
    1890                1895                1900
Leu Lys Asn Ala Ser Gly Ser Ile Glu Met Gln Val Val Ala Gly Gly
1905                1910                1915                1920
Asp Val Ser Val Val Thr Gly His Gln Gln Glu Pro Ala Ser Ser Ser
                1925                1930                1935
Leu Ser Phe Thr Gly Leu Thr Ser Ser Ser Ile Phe Gln Asp Asp Leu
            1940                1945                1950
Gly Pro Pro Gln Cys Lys Ser Ile Thr Leu Glu Arg Gly Pro Asp Gly
        1955                1960                1965
Leu Gly Phe Ser Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu
    1970                1975                1980
Pro Ile Tyr Val Lys Thr Val Phe Ala Lys Gly Ala Ala Ser Glu Asp
1985                1990                1995                2000
Gly Arg Leu Lys Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser
                2005                2010                2015
Leu Glu Gly Val Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr
            2020                2025                2030
Lys Gly Thr Val Thr Leu Met Val Leu Ser
        2035                2040

<210> 13
<211> 84
<212> PRT
<213> Homo sapiens

<400> 13
Lys Ser Ile Thr Leu Glu Arg Gly Pro Asp Gly Leu Gly Phe Ser Ile
 1               5                  10                  15
Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu Pro Ile Tyr Val Lys
            20                  25                  30
Thr Val Phe Ala Lys Gly Ala Ala Ser Glu Asp Gly Arg Leu Lys Arg
        35                  40                  45
Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser Leu Glu Gly Val Thr
    50                  55                  60
His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr Lys Gly Thr Val Thr
65                  70                  75                  80
Leu Met Val Leu

