                         SEQUENCE LISTING

<110>  ZymoGenetics, Inc.
       Moore, Margaret D.
       Snavely, Marshall D.
       Fox, Brian A.
       Hoyos, Gabriela H.
 
<120>  SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT

<130>  06-47PC

<150>  60/912,647
<151>  2007-04-18

<150>  60/914,682
<151>  2007-04-27

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  974
<212>  DNA
<213>  Homo sapiens

<400>  1
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagatctga gcccaaatct      120

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaggtggt gggggatccg gcggtggcgg aagtggaggc      840

ggtggctctg gtggtggcgg atctggcgga ggaggcagcg gcggaggtgg gtctgggggt      900

ggaggctccg gaccgggtaa ataaagcccg ggcaatctta aactagaggc gcgccgccag      960

ccccctgatg gggg                                                        974


<210>  2
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Pro Gly Lys 
305         


<210>  3
<211>  1623
<212>  DNA
<213>  Homo sapiens

<400>  3
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagatctga gcccaaatct      120

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaggtggt gggggatccg gcggtggcgg aagtggaggc      840

ggtggctctg gtggtggcgg atctggcgga ggaggcagcg gcggaggtgg gtctgggggt      900

ggaggctccg gaggcggggg aagcggggag cccaaatctt cagacaaaac tcacacatgc      960

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa     1020

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg     1080

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1140

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1200

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1260

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1320

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1380

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1440

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1500

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1560

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1620

aaa                                                                   1623


<210>  4
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
305                 310                 315                 320 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                325                 330                 335     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            340                 345                 350         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        355                 360                 365             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    370                 375                 380                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
385                 390                 395                 400 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                405                 410                 415     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            420                 425                 430         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        435                 440                 445             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    450                 455                 460                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
465                 470                 475                 480 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                485                 490                 495     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            500                 505                 510         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        515                 520                 525             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535                 540     


<210>  5
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  5
gagcccagat cttcagacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgag       60

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc catcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  6
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  7
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  7
gagcccaaat cttcagacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgag       60

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc catcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  8
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  9
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  9
gagcccaaat cttcagacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  10
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  11
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40      


<210>  12
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  12
cagccaggaa atccatgccg agttgagacg cttccgtaga tctgagccca aatcttcaga       60

caaaactcac                                                              70


<210>  13
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  13
gccaccgcct ccacttccgc caccgccgga tcccccacca cctttacccg gagacaggga       60

gag                                                                     63


<210>  14
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  14
ggaggcagcg gcggaggtgg gtctgggggt ggaggctccg gaccgggtaa ataaagc          57


<210>  15
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  15
cccccatcag ggggctggcg gcgcgcctct agtttaagat tgcccgggct ttatttaccc       60

ggtccggagc c                                                            71


<210>  16
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  16
ggaagtggag gcggtggctc tggtggtggc ggatctggcg gaggaggcag cggcggaggt       60


<210>  17
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  17
ggaggctccg gaggcggggg aagcggggag cccaaatctt cagacaaa                    48


<210>  18
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  18
gtttaagatt gcccgggctt tatttacccg gagacaggga                             40


<210>  19
<211>  924
<212>  DNA
<213>  Homo sapiens

<400>  19
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagatctga gcccaaatct      120

tcagacaaaa ctcacacatc cccaccgtcc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaggtggt gggggatccg gcggtggcgg aagtggaggc      840

ggtggctctg gtggtggcgg atctggcgga ggaggcagcg gcggaggtgg gtctgggggt      900

ggaggctccg gaccgggtaa ataa                                             924


<210>  20
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
        35                  40                  45              


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Pro Gly Lys 
305         


<210>  21
<211>  1578
<212>  DNA
<213>  Homo sapiens

<400>  21
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagatctga gcccaaatct      120

tcagacaaaa ctcacacatc cccaccgtcc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaggtggt gggggatccg gcggtggcgg aagtggaggc      840

ggtggctctg gtggtggcgg atctggcgga ggaggcagcg gcggaggtgg gtctgggggt      900

ggaggctccg gaggcggggg aagcggggca cctgaactcc tggggggacc gtcagtcttc      960

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     1020

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1080

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1140

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1200

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1260

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1320

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1380

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1440

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1500

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1560

tccctgtctc cgggtaaa                                                   1578


<210>  22
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
        35                  40                  45              


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            500                 505                 510         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 525     


<210>  23
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  23
cagccaggaa atccatgccg agttgagacg cttccgtaga tctgagccca aatcttcaga       60

caaaactcac                                                              70


<210>  24
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  24
tcttcagaca aaactcacac atccccaccg tccccagcac ctgaactcct gg               52


<210>  25
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member.

<400>  25
gccaccgcct ccacttccgc caccgccgga tcccccacca cctttacccg gagacaggga       60

gag                                                                     63


<210>  26
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  26
ggaggctccg gaggcggggg aagcggggag cccaaatctt cagacaaa                    48


<210>  27
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  27
gtttaagatt gcccgggctt tatttacccg gagacaggga                             40


<210>  28
<211>  927
<212>  DNA
<213>  Homo sapiens

<400>  28
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagatctga gcccaaatct      120

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaaaacct actaccactc ccgcacctag gcctcctact      840

cctgcaccaa ctattgcttc acaacctcta agtttaagac ctgaagctag tcgacctgca      900

gcaggtggct ccggaccggg taaataa                                          927


<210>  29
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Pro Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ser 
    290                 295                 300                 


Gly Pro Gly Lys 
305             


<210>  30
<211>  1626
<212>  DNA
<213>  Homo sapiens

<400>  30
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagatctga gcccaaatct      120

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      180

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      240

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      300

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      360

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      420

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      480

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      540

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      600

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      660

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      720

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      780

agcctctccc tgtctccggg taaaaaacct actaccactc ccgcacctag gcctcctact      840

cctgcaccaa ctattgcttc acaacctcta agtttaagac ctgaagctag tcgacctgca      900

gcaggtggct ccggaggcgg gggaagcggg gagcccaaat cttcagacaa aactcacaca      960

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1020

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1080

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1140

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1200

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1260

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1320

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1380

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1440

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1500

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1560

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1620

ggtaaa                                                                1626


<210>  31
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        35                  40                  45              


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    50                  55                  60                  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
65                  70                  75                  80  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                85                  90                  95      


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            100                 105                 110         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        115                 120                 125             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    130                 135                 140                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
145                 150                 155                 160 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                165                 170                 175     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            180                 185                 190         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        195                 200                 205             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    210                 215                 220                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
225                 230                 235                 240 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                245                 250                 255     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Pro Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
305                 310                 315                 320 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                325                 330                 335     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            340                 345                 350         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        355                 360                 365             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    370                 375                 380                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
385                 390                 395                 400 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                405                 410                 415     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            420                 425                 430         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        435                 440                 445             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    450                 455                 460                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
465                 470                 475                 480 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                485                 490                 495     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            500                 505                 510         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        515                 520                 525             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535                 540         


<210>  32
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  32
aaacctacta ccactcccgc acctaggcct cctactcctg caccaactat tgcttcacaa       60

cctctaagtt taagacctga agctagtcga cctgcagcag gt                         102


<210>  33
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  33

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly 
        


<210>  34
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  34
tgcaggagta ggaggcctag gtgcgggagt ggtagtaggt tttttacccg gagacaggga       60

gag                                                                     63


<210>  35
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  35
ctaagtttaa gacctgaagc tagtcgacct gcagcaggtg gctccggacc gggtaaataa       60

ag                                                                      62


<210>  36
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  36
cctaggcctc ctactcctgc accaactatt gcttcacaac ctctaagttt aagacctgaa       60

gct                                                                     63


<210>  37
<211>  1527
<212>  DNA
<213>  Homo sapiens

<400>  37
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

atccagatga cccagtcccc gagctccctg tccgcctctg tgggcgatag ggtcaccatc      120

acctgccgtg ccagtcagga tgtgaatact gctgtagcct ggtatcaaca gaaaccagga      180

aaagctccga aactactgat ttactcggca tccttcctct actctggagt cccttctcgc      240

ttctctggat ccagatctgg gacggatttc actctgacca tcagcagtct gcagccggaa      300

gacttcgcaa cttattactg tcagcaacat tatactactc ctcccacgtt cggacagggt      360

accaaggtgg agatcaaagg tggtggtggt tctggcggcg gcggctccgg tggaggtggt      420

tctggtggtg gtggttctgg tggtggtggt tctgaggttc agctggtgga gtctggcggt      480

ggcctggtgc agccaggggg ctcactccgt ttgtcctgtg cagcttctgg cttcaacatt      540

aaagacacct atatacactg ggtgcgtcag gccccgggta agggcctgga atgggttgca      600

aggatttatc ctacgaatgg ttatactaga tatgccgata gcgtcaaggg ccgtttcact      660

ataagcgcag acacatccaa aaacacagcc tacctgcaga tgaacagcct gcgtgctgag      720

gacactgccg tctattattg ttctagatgg ggaggggacg gcttctatgc tatggactac      780

tggggtcaag gaaccctggt caccgtctcc tcgggtggag gtggttctga gcccaaatct      840

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      900

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      960

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1020

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1080

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1140

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1200

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1260

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1320

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1380

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1440

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1500

agcctctccc tgtctccggg taaataa                                         1527


<210>  38
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
        195                 200                 205             


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
    210                 215                 220                 


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505             


<210>  39
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  39
actttgcctt tctctccaca ggtgtccagg gaattcatat aggccggcca ccatgaagtt       60

gcctgttagg                                                              70


<210>  40
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  40
actgctggaa gcaggaatcc agaacatcag caccaacagc ctaacaggca acttcat          57


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  41
attcctgctt ccagcagtga tatccagatg acccag                                 36


<210>  42
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  42
agaaccacct ccacccgagg agacggtgac cagggttcct tg                          42


<210>  43
<211>  909
<212>  DNA
<213>  Homo sapiens

<400>  43
atgaaaaaga atatcgcatt tcttcttgca tctatgttcg ttttttctat tgctacaaac       60

gcgtacgctg atatccagat gacccagtcc ccgagctccc tgtccgcctc tgtgggcgat      120

agggtcacca tcacctgccg tgccagtcag gatgtgaata ctgctgtagc ctggtatcaa      180

cagaaaccag gaaaagctcc gaaactactg atttactcgg catccttcct ctactctgga      240

gtcccttctc gcttctctgg atccagatct gggacggatt tcactctgac catcagcagt      300

ctgcagccgg aagacttcgc aacttattac tgtcagcaac attatactac tcctcccacg      360

ttcggacagg gtaccaaggt ggagatcaaa ggtggtggtg gttctggcgg cggcggctcc      420

ggtggaggtg gttctggtgg tggtggttct ggtggtggtg gttctgaggt tcagctggtg      480

gagtctggcg gtggcctggt gcagccaggg ggctcactcc gtttgtcctg tgcagcttct      540

ggcttcaaca ttaaagacac ctatatacac tgggtgcgtc aggccccggg taagggcctg      600

gaatgggttg caaggattta tcctacgaat ggttatacta gatatgccga tagcgtcaag      660

ggccgtttca ctataagcgc agacacatcc aaaaacacag cctacctgca gatgaacagc      720

ctgcgtgctg aggacactgc cgtctattat tgttctagat ggggagggga cggcttctat      780

gctatggact actggggtca aggaaccctg gtcaccgtct cctcgcgggc tgatgcttcg      840

gccgctggat ccgaacaaaa gctgatctca gaagaagacc taaactcaca tcaccatcac      900

catcactaa                                                              909


<210>  44
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser 
1               5                   10                  15      


Ile Ala Thr Asn Ala Tyr Ala Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
        195                 200                 205             


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
                245                 250                 255     


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Arg Ala Asp Ala Ser Ala Ala Gly Ser Glu Gln Lys Leu 
        275                 280                 285             


Ile Ser Glu Glu Asp Leu Asn Ser His His His His His His 
    290                 295                 300         


<210>  45
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  45
ggtggaggtg gttctgagcc caaatcttca gacaaaactc acacatg                     47


<210>  46
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  46
cccagagctg ttttaaggcg cgcctctaga tttatttacc cggagacag                   49


<210>  47
<211>  2346
<212>  DNA
<213>  Homo sapiens

<400>  47
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

atccagatga cccagtcccc gagctccctg tccgcctctg tgggcgatag ggtcaccatc      120

acctgccgtg ccagtcagga tgtgaatact gctgtagcct ggtatcaaca gaaaccagga      180

aaagctccga aactactgat ttactcggca tccttcctct actctggagt cccttctcgc      240

ttctctggat ccagatctgg gacggatttc actctgacca tcagcagtct gcagccggaa      300

gacttcgcaa cttattactg tcagcaacat tatactactc ctcccacgtt cggacagggt      360

accaaggtgg agatcaaagg tggtggtggt tctggcggcg gcggctccgg tggaggtggt      420

tctggtggtg gtggttctgg tggtggtggt tctgaggttc agctggtgga gtctggcggt      480

ggcctggtgc agccaggggg ctcactccgt ttgtcctgtg cagcttctgg cttcaacatt      540

aaagacacct atatacactg ggtgcgtcag gccccgggta agggcctgga atgggttgca      600

aggatttatc ctacgaatgg ttatactaga tatgccgata gcgtcaaggg ccgtttcact      660

ataagcgcag acacatccaa aaacacagcc tacctgcaga tgaacagcct gcgtgctgag      720

gacactgccg tctattattg ttctagatgg ggaggggacg gcttctatgc tatggactac      780

tggggtcaag gaaccctggt caccgtctcc tcgggtggag gtggttctga gcccaaatct      840

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      900

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      960

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1020

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1080

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1140

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1200

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1260

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1320

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1380

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1440

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1500

agcctctccc tgtctccggg taaaggtggt gggggatccg gcggtggcgg aagtggaggc     1560

ggtggctctg gtggtggcgg atctggcgga ggaggcagcg gcggaggtgg gtctgggggt     1620

ggaggctccg gaggcggggg aagcggggag cccaaatctt cagacaaaac tcacacatgc     1680

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa     1740

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg     1800

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1860

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1920

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1980

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     2040

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     2100

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     2160

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     2220

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     2280

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     2340

aaataa                                                                2346


<210>  48
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
        195                 200                 205             


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
    210                 215                 220                 


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
545                 550                 555                 560 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                565                 570                 575     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            580                 585                 590         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        595                 600                 605             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    610                 615                 620                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
625                 630                 635                 640 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                645                 650                 655     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            660                 665                 670         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        675                 680                 685             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    690                 695                 700                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
705                 710                 715                 720 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                725                 730                 735     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            740                 745                 750         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        755                 760                 765             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780     


<210>  49
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  49
actttgcctt tctctccaca ggtgtcctcg agaattcata taggccggcc accatgaagt       60

tgcctgttag g                                                            71


<210>  50
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  50
attcctgctt ccagcagtga tatccagatg acccagtccc cgagctccct g                51


<210>  51
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer member

<400>  51
tgtgtgagtt ttgtctgaag atttgggctc agaaccacct ccacccgagg agacggtgac       60

cag                                                                     63


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  52

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  VARIANT
<222>  (2)..(5)
<223>  Gly or is absent

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<220>
<221>  VARIANT
<222>  (8)..(11)
<223>  Gly or is absent

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<220>
<221>  VARIANT
<222>  (14)..(17)
<223>  Gly or is absent

<400>  53

Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  variant
<222>  (4)..(4)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<220>
<221>  variant
<222>  (8)..(8)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<400>  54

Gly Gly Gly Xaa Gly Gly Gly Xaa Gly Gly Gly 
1               5                   10      


<210>  55
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  variant
<222>  (2)..(12)
<223>  Gly or is absent

<220>
<221>  variant
<222>  (15)..(25)
<223>  Gly or is absent

<400>  55

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Gly Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  56

Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly 
1               5                   10      


<210>  57
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  58
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  58

Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Glu Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  59
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  59
atgggatgga gctggatctt tctctttctt ctgtcaggaa ctgcaggtgt cctctctgag       60

gttcagctgg tggagtctgg cggtggcctg gtgcagccag ggggctcact ccgtttgtcc      120

tgtgcagctt ctggcttcaa cattaaagac acctatatac actgggtgcg tcaggccccg      180

ggtaagggcc tggaatgggt tgcaaggatt tatcctacga atggttatac tagatatgcc      240

gatagcgtca agggccgttt cactataagc gcagacacat ccaaaaacac agcctacctg      300

cagatgaaca gcctgcgtgc tgaggacact gccgtctatt attgttctag atggggaggg      360

gacggcttct atgctatgga ctactggggt caaggaaccc tggtcaccgt ctcctcgggc      420

ggcggcggct ccggcggggg tggaagtggt ggtggtggtt ctgatatcca gatgacccag      480

tccccgagct ccctgtccgc ctctgtgggc gatagggtca ccatcacctg ccgtgccagt      540

caggatgtga atactgctgt agcctggtat caacagaaac caggaaaagc tccgaaacta      600

ctgatttact cggcatcctt cctctactct ggagtccctt ctcgcttctc tggatccaga      660

tctgggacgg atttcactct gaccatcagc agtctgcagc cggaagactt cgcaacttat      720

tactgtcagc aacattatac tactcctccc acgttcggac agggtaccaa ggtggagatc      780

aaaggtggag gtggttctga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc      840

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      900

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      960

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1020

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1080

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1140

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1200

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1260

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1320

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1380

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1440

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaataa        1497


<210>  60
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
        195                 200                 205             


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  61
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
1               5                   10                  15      


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
            20                  25                  30          


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
        35                  40                  45              


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
    50                  55                  60                  


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
65                  70                  75                  80  


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
                85                  90                  95      


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
            100                 105                 110         


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
        115                 120                 125             


His Gly Ser Glu Asp Ser 
    130                 


<210>  62
<211>  596
<212>  DNA
<213>  Homo sapiens

<400>  62
ttctgaaatg agctgttgac aattaatcat cggctcgtat aatgtgtgga attgtgagcg       60

gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgcaa ggtcaagatc      120

gccacatgat tagaatgcgt caacttatag atattgttga tcagctgaaa aattatgtga      180

atgacctggt tccggaattc ctgccggctc cggaagatgt tgagaccaac tgtgagtggt      240

ccgctttctc ctgtttccag aaagcccagc tgaaatccgc aaacaccggt aacaacgaac      300

gtatcatcaa cgtttccatt aaaaaactga aacgtaaacc gccgtccacc aacgcaggtc      360

gtcgtcagaa acaccgtctg acctgcccgt cctgtgattc ttatgagaaa aaaccgccga      420

aagaattcct ggaacgtttc aaatccctgc tgcagaaaat gattcaccag cacctgtcct      480

ctcgtaccca cggttccgaa gattcctgat gttttggcgg atgagataag attttcagcc      540

tgatacagat taaatcagaa cgcagaagcg gtctgataaa acagaatttg cctggc          596


<210>  63
<211>  2301
<212>  DNA
<213>  Homo sapiens

<400>  63
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

atccagatga cccagtcccc gagctccctg tccgcctctg tgggcgatag ggtcaccatc      120

acctgccgtg ccagtcagga tgtgaatact gctgtagcct ggtatcaaca gaaaccagga      180

aaagctccga aactactgat ttactcggca tccttcctct actctggagt cccttctcgc      240

ttctctggat ccagatctgg gacggatttc actctgacca tcagcagtct gcagccggaa      300

gacttcgcaa cttattactg tcagcaacat tatactactc ctcccacgtt cggacagggt      360

accaaggtgg agatcaaagg tggtggtggt tctggcggcg gcggctccgg tggaggtggt      420

tctggtggtg gtggttctgg tggtggtggt tctgaggttc agctggtgga gtctggcggt      480

ggcctggtgc agccaggggg ctcactccgt ttgtcctgtg cagcttctgg cttcaacatt      540

aaagacacct atatacactg ggtgcgtcag gccccgggta agggcctgga atgggttgca      600

aggatttatc ctacgaatgg ttatactaga tatgccgata gcgtcaaggg ccgtttcact      660

ataagcgcag acacatccaa aaacacagcc tacctgcaga tgaacagcct gcgtgctgag      720

gacactgccg tctattattg ttctagatgg ggaggggacg gcttctatgc tatggactac      780

tggggtcaag gaaccctggt caccgtctcc tcgggtggag gtggttctga gcccaaatct      840

tcagacaaaa ctcacacatc cccaccgtcc ccagcacctg aactcctggg gggaccgtca      900

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      960

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1020

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1080

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1140

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1200

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1260

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1320

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1380

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1440

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1500

agcctctccc tgtctccggg taaaggtggt gggggatccg gcggtggcgg aagtggaggc     1560

ggtggctctg gtggtggcgg atctggcgga ggaggcagcg gcggaggtgg gtctgggggt     1620

ggaggctccg gaggcggggg aagcggggca cctgaactcc tggggggacc gtcagtcttc     1680

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     1740

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1800

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1860

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1920

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1980

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     2040

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     2100

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     2160

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     2220

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     2280

tccctgtctc cgggtaaata a                                               2301


<210>  64
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
        195                 200                 205             


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
    210                 215                 220                 


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
        275                 280                 285             


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
545                 550                 555                 560 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                565                 570                 575     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            580                 585                 590         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        595                 600                 605             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    610                 615                 620                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
625                 630                 635                 640 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                645                 650                 655     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            660                 665                 670         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        675                 680                 685             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    690                 695                 700                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
705                 710                 715                 720 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                725                 730                 735     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            740                 745                 750         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760                 765     


<210>  65
<211>  2349
<212>  DNA
<213>  Homo sapiens

<400>  65
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

atccagatga cccagtcccc gagctccctg tccgcctctg tgggcgatag ggtcaccatc      120

acctgccgtg ccagtcagga tgtgaatact gctgtagcct ggtatcaaca gaaaccagga      180

aaagctccga aactactgat ttactcggca tccttcctct actctggagt cccttctcgc      240

ttctctggat ccagatctgg gacggatttc actctgacca tcagcagtct gcagccggaa      300

gacttcgcaa cttattactg tcagcaacat tatactactc ctcccacgtt cggacagggt      360

accaaggtgg agatcaaagg tggtggtggt tctggcggcg gcggctccgg tggaggtggt      420

tctggtggtg gtggttctgg tggtggtggt tctgaggttc agctggtgga gtctggcggt      480

ggcctggtgc agccaggggg ctcactccgt ttgtcctgtg cagcttctgg cttcaacatt      540

aaagacacct atatacactg ggtgcgtcag gccccgggta agggcctgga atgggttgca      600

aggatttatc ctacgaatgg ttatactaga tatgccgata gcgtcaaggg ccgtttcact      660

ataagcgcag acacatccaa aaacacagcc tacctgcaga tgaacagcct gcgtgctgag      720

gacactgccg tctattattg ttctagatgg ggaggggacg gcttctatgc tatggactac      780

tggggtcaag gaaccctggt caccgtctcc tcgggtggag gtggttctga gcccaaatct      840

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      900

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      960

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1020

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1080

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1140

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1200

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1260

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1320

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1380

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1440

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1500

agcctctccc tgtctccggg taaaaaacct actaccactc ccgcacctag gcctcctact     1560

cctgcaccaa ctattgcttc acaacctcta agtttaagac ctgaagctag tcgacctgca     1620

gcaggtggct ccggaggcgg gggaagcggg gagcccaaat cttcagacaa aactcacaca     1680

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1740

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1800

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1860

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1920

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1980

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     2040

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     2100

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     2160

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2220

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2280

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2340

ggtaaataa                                                             2349


<210>  66
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
        195                 200                 205             


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
    210                 215                 220                 


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Pro Thr Thr 
            500                 505                 510         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        515                 520                 525             


Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        675                 680                 685             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    690                 695                 700                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
705                 710                 715                 720 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                725                 730                 735     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            740                 745                 750         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        755                 760                 765             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780         


<210>  67
<211>  2334
<212>  DNA
<213>  Homo sapiens

<400>  67
atgaactttg tgctcagctt gattttcctt gccctcattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcgc tttcagtagc tatgccatgt cttgggttcg ccagagtccg      180

gaaaagaggc tggagtgggt cgcaaccatt agcagtggtg gtcattacac cttctatcca      240

gacagtgtga agggtcgctt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatttatt actgtgcaag acgttactat      360

gctctggact actggggtca aggaacctca gtcaccgtct cctcaggtgg tggtggttct      420

ggcggcggcg gctccggcgg gggtggaagt ggtggtggtg gttctggtgg tggtggttct      480

gacattgtga tgacccagtc tcaaaaattc atgtccacat cactaggaga cagggtcagc      540

gtctcctgca aggccagtca gaatgtgctt actaatgtag cctggtatca acaaaaacca      600

gggcaatctc ctaaaactct gatttattcg gcatcctacc ggtacagtgg agtccctgat      660

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcat tgttcagtct      720

gaagacttgg cagagtattt ctgtcaacaa tataacatct atccgtggac gttcggtgga      780

ggcaccaagc tggaaatcaa aggtggaggt ggttctgagc ccaaatcttc agacaaaact      840

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggta aaggtggtgg gggatccggc ggtggcggaa gtggaggcgg tggctctggt     1560

ggtggcggat ctggcggagg aggcagcggc ggaggtgggt ctgggggtgg aggctccgga     1620

ggcgggggaa gcggggagcc caaatcttca gacaaaactc acacatgccc accgtgccca     1680

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1740

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1800

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1860

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1920

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1980

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     2040

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     2100

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     2160

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     2220

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     2280

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa ataa           2334


<210>  68
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Asn Phe Val Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly His Tyr Thr Phe Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Leu Gly 
                165                 170                 175     


Asp Arg Val Ser Val Ser Cys Lys Ala Ser Gln Asn Val Leu Thr Asn 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ile Val Gln Ser 
225                 230                 235                 240 


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Trp 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
545                 550                 555                 560 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                565                 570                 575     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            580                 585                 590         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        595                 600                 605             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    610                 615                 620                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
625                 630                 635                 640 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                645                 650                 655     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            660                 665                 670         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        675                 680                 685             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    690                 695                 700                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                725                 730                 735     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            740                 745                 750         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        755                 760                 765             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775         


<210>  69
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  69
atgaactttg tgctcagctt gattttcctt gccctcattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcgc tttcagtagc tatgccatgt cttgggttcg ccagagtccg      180

gaaaagaggc tggagtgggt cgcaaccatt agcagtggtg gtcattacac cttctatcca      240

gacagtgtga agggtcgctt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatttatt actgtgcaag acgttactat      360

gctctggact actggggtca aggaacctca gtcaccgtct cctcaggtgg tggtggttct      420

ggcggcggcg gctccggcgg gggtggaagt ggtggtggtg gttctggtgg tggtggttct      480

gacattgtga tgacccagtc tcaaaaattc atgtccacat cactaggaga cagggtcagc      540

gtctcctgca aggccagtca gaatgtgctt actaatgtag cctggtatca acaaaaacca      600

gggcaatctc ctaaaactct gatttattcg gcatcctacc ggtacagtgg agtccctgat      660

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcat tgttcagtct      720

gaagacttgg cagagtattt ctgtcaacaa tataacatct atccgtggac gttcggtgga      780

ggcaccaagc tggaaatcaa aggtggaggt ggttctgagc ccaaatcttc agacaaaact      840

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggta aataa                                                      1515


<210>  70
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asn Phe Val Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly His Tyr Thr Phe Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Leu Gly 
                165                 170                 175     


Asp Arg Val Ser Val Ser Cys Lys Ala Ser Gln Asn Val Leu Thr Asn 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ile Val Gln Ser 
225                 230                 235                 240 


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Trp 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 


<210>  71
<211>  1485
<212>  DNA
<213>  Homo sapiens

<400>  71
atgaactttg tgctcagctt gattttcctt gccctcattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcgc tttcagtagc tatgccatgt cttgggttcg ccagagtccg      180

gaaaagaggc tggagtgggt cgcaaccatt agcagtggtg gtcattacac cttctatcca      240

gacagtgtga agggtcgctt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatttatt actgtgcaag acgttactat      360

gctctggact actggggtca aggaacctca gtcaccgtct cctcaggcgg cggcggctcc      420

ggcgggggtg gaagtggtgg tggtggttct gacattgtga tgacccagtc tcaaaaattc      480

atgtccacat cactaggaga cagggtcagc gtctcctgca aggccagtca gaatgtgctt      540

actaatgtag cctggtatca acaaaaacca gggcaatctc ctaaaactct gatttattcg      600

gcatcctacc ggtacagtgg agtccctgat cgcttcacag gcagtggatc tgggacagat      660

ttcactctca ccatcagcat tgttcagtct gaagacttgg cagagtattt ctgtcaacaa      720

tataacatct atccgtggac gttcggtgga ggcaccaagc tggaaatcaa aggtggaggt      780

ggttctgagc ccaaatcttc agacaaaact cacacatgcc caccgtgccc agcacctgaa      840

gccgaggggg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      900

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      960

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1020

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1080

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccatc ctccatcgag     1140

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1200

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1260

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1320

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1380

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1440

aaccactaca cgcagaagag cctctccctg tctccgggta aataa                     1485


<210>  72
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Asn Phe Val Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly His Tyr Thr Phe Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Leu Gly Asp Arg Val Ser Val Ser Cys Lys Ala Ser 
                165                 170                 175     


Gln Asn Val Leu Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Thr Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ile Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
225                 230                 235                 240 


Tyr Asn Ile Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                245                 250                 255     


Lys Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


       




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