                         SEQUENCE LISTING

<110>  Amgen Inc.
       Gaffen, et al
 
<120>  Identification of a Pre-Ligand Assembly Domain (PLAD) and Ligand
        Binding Domain in the IL-17 Receptor

<130>  01017/43857

<150>  US 60/925,367
<151>  2007-04-20

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  833
<212>  PRT
<213>  Mus musculus


<220>
<223>  Interleukin 17 receptor A

<400>  1

Ser Pro Arg Leu Leu Asp Phe Pro Ala Pro Val Cys Ala Gln Glu Gly 
1               5                   10                  15      


Leu Ser Cys Arg Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile 
            20                  25                  30          


His Pro Lys Asn Leu Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn 
        35                  40                  45              


Leu Ser Val Ser Ser Thr Gln His Gly Glu Leu Val Pro Val Leu His 
    50                  55                  60                  


Val Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly 
65                  70                  75                  80  


Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val 
                85                  90                  95      


Lys Phe Gln Phe Leu Ser Met Leu Gln His His Arg Lys Arg Trp Arg 
            100                 105                 110         


Phe Ser Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val 
        115                 120                 125             


Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His 
    130                 135                 140                 


Lys Ser Lys Ile Ile Phe Val Pro Asp Cys Glu Asp Ser Lys Met Lys 
145                 150                 155                 160 


Met Thr Thr Ser Cys Val Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile 
                165                 170                 175     


Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp Phe Thr Leu 
            180                 185                 190         


Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser Phe Ser Asp 
        195                 200                 205             


Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile Phe Ala Pro 
    210                 215                 220                 


Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe Thr Leu Ser 
225                 230                 235                 240 


Lys Phe His Trp Cys Cys His His His Val Gln Val Gln Pro Phe Phe 
                245                 250                 255     


Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ala Val Thr Val Pro Cys 
            260                 265                 270         


Pro Val Ile Ser Asn Thr Thr Val Pro Lys Pro Val Ala Asp Tyr Ile 
        275                 280                 285             


Pro Leu Trp Val Tyr Gly Leu Ile Thr Leu Ile Ala Ile Leu Leu Val 
    290                 295                 300                 


Gly Ser Val Ile Val Leu Ile Ile Cys Met Thr Trp Arg Leu Ser Gly 
305                 310                 315                 320 


Ala Asp Gln Glu Lys His Gly Asp Asp Ser Lys Ile Asn Gly Ile Leu 
                325                 330                 335     


Pro Val Ala Asp Leu Thr Pro Pro Pro Leu Arg Pro Arg Lys Val Trp 
            340                 345                 350         


Ile Val Tyr Ser Ala Asp His Pro Leu Tyr Val Glu Val Val Leu Lys 
        355                 360                 365             


Phe Ala Gln Phe Leu Ile Thr Ala Cys Gly Thr Glu Val Ala Leu Asp 
    370                 375                 380                 


Leu Leu Glu Glu Gln Val Ile Ser Glu Val Gly Val Met Thr Trp Val 
385                 390                 395                 400 


Ser Arg Gln Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Ile 
                405                 410                 415     


Leu Cys Ser Arg Gly Thr Gln Ala Lys Trp Lys Ala Ile Leu Gly Trp 
            420                 425                 430         


Ala Glu Pro Ala Val Gln Leu Arg Cys Asp His Trp Lys Pro Ala Gly 
        435                 440                 445             


Asp Leu Phe Thr Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg 
    450                 455                 460                 


Pro Ala Cys Phe Gly Thr Tyr Val Val Cys Tyr Phe Ser Gly Ile Cys 
465                 470                 475                 480 


Ser Glu Arg Asp Val Pro Asp Leu Phe Asn Ile Thr Ser Arg Tyr Pro 
                485                 490                 495     


Leu Met Asp Arg Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu 
            500                 505                 510         


Met Phe Glu Pro Gly Arg Met His His Val Arg Glu Leu Thr Gly Asp 
        515                 520                 525             


Asn Tyr Leu Gln Ser Pro Ser Gly Arg Gln Leu Lys Glu Ala Val Leu 
    530                 535                 540                 


Arg Phe Gln Glu Trp Gln Thr Gln Cys Pro Asp Trp Phe Glu Arg Glu 
545                 550                 555                 560 


Asn Leu Cys Leu Ala Asp Gly Gln Asp Leu Pro Ser Leu Asp Glu Glu 
                565                 570                 575     


Val Phe Glu Asp Pro Leu Leu Pro Pro Gly Gly Gly Ile Val Lys Gln 
            580                 585                 590         


Gln Pro Leu Val Arg Glu Leu Pro Ser Asp Gly Cys Leu Val Val Asp 
        595                 600                 605             


Val Cys Val Ser Glu Glu Glu Ser Arg Met Ala Lys Leu Asp Pro Gln 
    610                 615                 620                 


Leu Trp Pro Gln Arg Glu Leu Val Ala His Thr Leu Gln Ser Met Val 
625                 630                 635                 640 


Leu Pro Ala Glu Gln Val Pro Ala Ala His Val Val Glu Pro Leu His 
                645                 650                 655     


Leu Pro Asp Gly Ser Gly Ala Ala Ala Gln Leu Pro Met Thr Glu Asp 
            660                 665                 670         


Ser Glu Ala Cys Pro Leu Leu Gly Val Gln Arg Asn Ser Ile Leu Cys 
        675                 680                 685             


Leu Pro Val Asp Ser Asp Asp Leu Pro Leu Cys Ser Thr Pro Met Met 
    690                 695                 700                 


Ser Pro Asp His Leu Gln Gly Asp Ala Arg Glu Gln Leu Glu Ser Leu 
705                 710                 715                 720 


Met Leu Ser Val Leu Gln Gln Ser Leu Ser Gly Gln Pro Leu Glu Ser 
                725                 730                 735     


Trp Pro Arg Pro Glu Val Val Leu Glu Gly Cys Thr Pro Ser Glu Glu 
            740                 745                 750         


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
        755                 760                 765             


Ser Pro Gln Pro Pro Glu Trp Leu Thr Glu Glu Glu Glu Leu Glu Leu 
    770                 775                 780                 


Gly Glu Pro Val Glu Ser Leu Ser Pro Glu Glu Leu Arg Ser Leu Arg 
785                 790                 795                 800 


Lys Leu Gln Arg Gln Leu Phe Phe Trp Glu Leu Glu Lys Asn Pro Gly 
                805                 810                 815     


Trp Asn Ser Leu Glu Pro Arg Arg Pro Thr Pro Glu Glu Gln Asn Pro 
            820                 825                 830         


Ser 
    


<210>  2
<211>  835
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Interleukin 17 receptor A

<400>  2

Ser Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly 
1               5                   10                  15      


Leu Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile 
            20                  25                  30          


His Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln 
        35                  40                  45              


Leu His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His 
    50                  55                  60                  


Ile Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly 
65                  70                  75                  80  


Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val 
                85                  90                  95      


Arg Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg 
            100                 105                 110         


Phe Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val 
        115                 120                 125             


Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His 
    130                 135                 140                 


Gln Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys 
145                 150                 155                 160 


Val Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile 
                165                 170                 175     


Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu 
            180                 185                 190         


Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His 
        195                 200                 205             


Met Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro 
    210                 215                 220                 


Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg 
225                 230                 235                 240 


Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe 
                245                 250                 255     


Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys 
            260                 265                 270         


Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu 
        275                 280                 285             


Trp Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser 
    290                 295                 300                 


Val Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly 
305                 310                 315                 320 


Ser Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala 
                325                 330                 335     


Ala Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile 
            340                 345                 350         


Tyr Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala 
        355                 360                 365             


Gln Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu 
    370                 375                 380                 


Glu Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg 
385                 390                 395                 400 


Gln Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys 
                405                 410                 415     


Ser Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala 
            420                 425                 430         


Pro Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe 
        435                 440                 445             


Thr Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys 
    450                 455                 460                 


Phe Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly 
465                 470                 475                 480 


Asp Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp 
                485                 490                 495     


Arg Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln 
            500                 505                 510         


Pro Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu 
        515                 520                 525             


Arg Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg 
    530                 535                 540                 


Asp Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr 
545                 550                 555                 560 


Ser Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu 
                565                 570                 575     


Glu Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu 
            580                 585                 590         


Val Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val 
        595                 600                 605             


Gly Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln 
    610                 615                 620                 


Pro Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala 
625                 630                 635                 640 


Ala Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala 
                645                 650                 655     


Asp Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys 
            660                 665                 670         


Pro Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu 
        675                 680                 685             


Pro Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala 
    690                 695                 700                 


Ser Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu 
705                 710                 715                 720 


Met Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly 
                725                 730                 735     


Cys Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu 
            740                 745                 750         


Glu Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg 
        755                 760                 765             


Ser Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu 
    770                 775                 780                 


Glu Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu 
785                 790                 795                 800 


Asp Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln 
                805                 810                 815     


Leu Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly 
            820                 825                 830         


Pro Ser Ala 
        835 


<210>  3
<211>  79
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse FN2

<400>  3

Pro Asn Ile Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser 
            20                  25                  30          


Phe Ser Asp Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile 
        35                  40                  45              


Phe Ala Pro Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe 
    50                  55                  60                  


Thr Leu Ser Lys Phe His Trp Cys Cys His His His Val Gln Val 
65                  70                  75                  


<210>  4
<211>  78
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human FN2

<400>  4

Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser 
            20                  25                  30          


Phe Pro His Met Glu Asn His Ser Cys Phe Glu His Met His His Ile 
        35                  40                  45              


Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu 
    50                  55                  60                  


Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln 
65                  70                  75              


<210>  5
<211>  21
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse linker

<400>  5

Asp Cys Glu Asp Ser Lys Met Lys Met Thr Thr Ser Cys Val Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human linker

<400>  6

Asp Cys Glu His Ala Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp 
            20      


<210>  7
<211>  100
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse FN2 + linker

<400>  7

Asp Cys Glu Asp Ser Lys Met Lys Met Thr Thr Ser Cys Val Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Asp Thr Gln 
            20                  25                  30          


His Leu Arg Val Asp Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr Gln 
        35                  40                  45              


Val Leu Leu Glu Ser Phe Ser Asp Ser Glu Asn His Ser Cys Phe Asp 
    50                  55                  60                  


Val Val Lys Gln Ile Phe Ala Pro Arg Gln Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ala Asn Val Thr Phe Thr Leu Ser Lys Phe His Trp Cys Cys His His 
                85                  90                  95      


His Val Gln Val 
            100 


<210>  8
<211>  99
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human FN2 + linker

<400>  8

Asp Cys Glu His Ala Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His 
            20                  25                  30          


Gln Leu Arg Val Ser Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln 
        35                  40                  45              


Ile Leu Leu Thr Ser Phe Pro His Met Glu Asn His Ser Cys Phe Glu 
    50                  55                  60                  


His Met His His Ile Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ser Asn Val Thr Leu Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His 
                85                  90                  95      


Gln Val Gln 
            


<210>  9
<211>  34
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse C-terminal extension

<400>  9

Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ala Val 
1               5                   10                  15      


Thr Val Pro Cys Pro Val Ile Ser Asn Thr Thr Val Pro Lys Pro Val 
            20                  25                  30          


Ala Asp 
        


<210>  10
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human C-terminal extension

<400>  10

Ile Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser 
1               5                   10                  15      


Ala Thr Val Ser Cys Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro 
            20                  25                  30          


Asp 
    


<210>  11
<211>  113
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse FN2 + C-terminal extension

<400>  11

Pro Asn Ile Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser 
            20                  25                  30          


Phe Ser Asp Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile 
        35                  40                  45              


Phe Ala Pro Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe 
    50                  55                  60                  


Thr Leu Ser Lys Phe His Trp Cys Cys His His His Val Gln Val Gln 
65                  70                  75                  80  


Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ala Val Thr 
                85                  90                  95      


Val Pro Cys Pro Val Ile Ser Asn Thr Thr Val Pro Lys Pro Val Ala 
            100                 105                 110         


Asp 
    


<210>  12
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human FN2 + C-terminal extension

<400>  12

Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser 
            20                  25                  30          


Phe Pro His Met Glu Asn His Ser Cys Phe Glu His Met His His Ile 
        35                  40                  45              


Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu 
    50                  55                  60                  


Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln 
65                  70                  75                  80  


Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr 
                85                  90                  95      


Val Ser Cys Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp 
            100                 105                 110     


<210>  13
<211>  134
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse FN2 + linker + C-terminal extension

<400>  13

Asp Cys Glu Asp Ser Lys Met Lys Met Thr Thr Ser Cys Val Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Asp Thr Gln 
            20                  25                  30          


His Leu Arg Val Asp Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr Gln 
        35                  40                  45              


Val Leu Leu Glu Ser Phe Ser Asp Ser Glu Asn His Ser Cys Phe Asp 
    50                  55                  60                  


Val Val Lys Gln Ile Phe Ala Pro Arg Gln Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ala Asn Val Thr Phe Thr Leu Ser Lys Phe His Trp Cys Cys His His 
                85                  90                  95      


His Val Gln Val Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu 
            100                 105                 110         


Arg His Ala Val Thr Val Pro Cys Pro Val Ile Ser Asn Thr Thr Val 
        115                 120                 125             


Pro Lys Pro Val Ala Asp 
    130                 


<210>  14
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human FN2 + linker + C-terminal extension

<400>  14

Asp Cys Glu His Ala Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His 
            20                  25                  30          


Gln Leu Arg Val Ser Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln 
        35                  40                  45              


Ile Leu Leu Thr Ser Phe Pro His Met Glu Asn His Ser Cys Phe Glu 
    50                  55                  60                  


His Met His His Ile Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ser Asn Val Thr Leu Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His 
                85                  90                  95      


Gln Val Gln Ile Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu 
            100                 105                 110         


Arg His Ser Ala Thr Val Ser Cys Pro Glu Met Pro Asp Thr Pro Glu 
        115                 120                 125             


Pro Ile Pro Asp 
    130         


<210>  15
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal extension for FN2 without linker

<400>  15

Leu Trp Asp 
1           


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Secretion signal of IgK

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  17
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Secretion signal of human IL-17RA

<400>  17

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala 
            20                  25                  30      


<210>  18
<211>  3288
<212>  DNA
<213>  Mus musculus


<220>
<223>  Interleukin 17 receptor A (IL17RA)

<400>  18
gtcgactgga acgagacgac ctgctgccga cgagcgccag tcctcggccg ggaaagccat       60

cgcgggccct cgctgtcgcg cggagccagc tgcgagcgct ccgcgaccgg gccgagggct      120

atggcgattc ggcgctgctg gccacgggtc gtccccgggc ccgcgctggg atggctgctt      180

ctgctgctga acgttctggc cccgggccgc gcctccccgc gcctcctcga cttcccggct      240

ccggtctgcg cgcaggaggg gctgagctgc agagtcaaga atagtacttg tctggatgac      300

agctggatcc accccaaaaa cctgaccccg tcttccccaa aaaacatcta tatcaatctt      360

agtgtttcct ctacccagca cggagaatta gtccctgtgt tgcatgttga gtggaccctg      420

cagacagatg ccagcatcct gtacctcgag ggtgcagagc tgtccgtcct gcagctgaac      480

accaatgagc ggctgtgtgt caagttccag tttctgtcca tgctgcagca tcaccgtaag      540

cggtggcggt tttccttcag ccactttgtg gtagatcctg gccaggagta tgaagtgact      600

gttcaccacc tgccgaagcc catccctgat ggggacccaa accacaaatc caagatcatc      660

tttgtgcctg actgtgagga cagcaagatg aagatgacta cctcatgcgt gagctcaggc      720

agcctttggg atcccaacat cactgtggag accttggaca cacagcatct gcgagtggac      780

ttcaccctgt ggaatgaatc caccccctac caggtcctgc tggaaagttt ctccgactca      840

gagaaccaca gctgctttga tgtcgttaaa caaatatttg cgcccaggca agaagaattc      900

catcagcgag ctaatgtcac attcactcta agcaagtttc actggtgctg ccatcaccac      960

gtgcaggtcc agcccttctt cagcagctgc ctaaatgact gtttgagaca cgctgtgact     1020

gtgccctgcc cagtaatctc aaataccaca gttcccaagc cagttgcaga ctacattccc     1080

ctgtgggtgt atggcctcat cacactcatc gccattctgc tggtgggatc tgtcatcgtg     1140

ctgatcatct gtatgacctg gaggctttct ggcgccgatc aagagaaaca tggtgatgac     1200

tccaaaatca atggcatctt gcccgtagca gacctgactc ccccacccct gaggcccagg     1260

aaggtctgga tcgtctactc ggccgaccac cccctctatg tggaggtggt cctaaagttc     1320

gcccagttcc tgatcactgc ctgtggcact gaagtagccc ttgacctcct ggaagagcag     1380

gttatctctg aggtgggggt catgacctgg gtgagccgac agaagcagga gatggtggag     1440

agcaactcca aaatcatcat cctgtgttcc cgaggcaccc aagcaaagtg gaaagctatc     1500

ttgggttggg ctgagcctgc tgtccagcta cggtgtgacc actggaagcc tgctggggac     1560

cttttcactg cagccatgaa catgatcctg ccagacttca agaggccagc ctgcttcggc     1620

acctacgttg tttgctactt cagtggcatc tgtagtgaga gggatgtccc cgacctcttc     1680

aacatcacct ccaggtaccc actcatggac agatttgagg aggtttactt ccggatccag     1740

gacctggaga tgtttgaacc cggccggatg caccatgtca gagagctcac aggggacaat     1800

tacctgcaga gccctagtgg ccggcagctc aaggaggctg tgcttaggtt ccaggagtgg     1860

caaacccagt gccccgactg gttcgagcgt gagaacctct gcttagctga tggccaagat     1920

cttccctccc tggatgaaga agtgtttgaa gacccactgc tgccaccagg gggaggaatt     1980

gtcaaacagc agcccctggt gcgggaactc ccatctgacg gctgccttgt ggtagatgtc     2040

tgtgtcagtg aggaagaaag tagaatggca aagctggacc ctcagctatg gccacagaga     2100

gagctagtgg ctcacaccct ccaaagcatg gtgctgccag cagagcaggt ccctgcagct     2160

catgtggtgg agcctctcca tctcccagac ggcagtggag cagctgccca gctgcccatg     2220

acagaggaca gcgaggcttg cccgctgctg ggggtccaga ggaacagcat cctttgcctc     2280

cccgtggact cagatgactt gccactctgt agcaccccaa tgatgtcacc tgaccacctc     2340

caaggcgatg caagagagca gctagaaagc ctaatgctct cggtgctgca gcagagcctg     2400

agtggacagc ccctggagag ctggccgagg ccagaggtgg tcctcgaggg ctgcacaccc     2460

tctgaggagg agcagcggca gtcggtgcag tcggaccagg gctacatctc caggagctcc     2520

ccgcagcccc ccgagtggct cacggaggag gaagagctag aactgggtga gcccgttgag     2580

tctctctctc ctgaggaact acggagcctg aggaagctcc agaggcagct tttcttctgg     2640

gagctcgaga agaaccctgg ctggaacagc ttggagccac ggagacccac cccagaagag     2700

cagaatccct cctaggcctc ctgagcctgc tacttaagag ggtgtatatt gtactctgtg     2760

tgtgcgtgcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgcg tgtgtgtgtg tgtgtgtgtg     2820

tgtgtgtgtg tgtagtgccc ggcttagaaa tgtgaacatc tgaatctgac atagtgttgt     2880

atacctgaag tcccagcact tgggaactga gacttgatga tctcctgaag ccaggtgttc     2940

agggccagtg tgaaaacata gcaagacctc agagaaatca atgcagacat cttggtactg     3000

atccctaaac acaccccttt ccctgataac ccgacatgag catctggtca tcattgcaca     3060

agaatccaca gcccgttccc agagctcata gccaagtgtg ttgctcattc cttgaatatt     3120

tattctgtac ctactattca tcagacattt ggaattcaaa aacaagttac atgacacagc     3180

cttagccact aagaagctta aaattcggta aggatgtaaa attagccagg atgaatagag     3240

ggctgctgcc ctggctgcag aagagcaggt cgtctcgttc cagtcgac                  3288


<210>  19
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Expression marker -- FLAG tag

<400>  19

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  20
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Purification tag

<400>  20

His His His His His His 
1               5       


<210>  21
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Spacer/Tag

<400>  21

Gly Ser Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser His His 
1               5                   10                  15      


His His His His 
            20  


<210>  22
<211>  115
<212>  PRT
<213>  Mus musculus


<220>
<223>  Mouse FN1

<400>  22

Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn Leu Ser Val Ser Ser 
1               5                   10                  15      


Thr Gln His Gly Glu Leu Val Pro Val Leu His Val Glu Trp Thr Leu 
            20                  25                  30          


Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala Glu Leu Ser Val 
        35                  40                  45              


Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Lys Phe Gln Phe Leu 
    50                  55                  60                  


Ser Met Leu Gln His His Arg Lys Arg Trp Arg Phe Ser Phe Ser His 
65                  70                  75                  80  


Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr Val His His Leu 
                85                  90                  95      


Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Lys Ser Lys Ile Ile 
            100                 105                 110         


Phe Val Pro 
        115 


<210>  23
<211>  115
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Human FN1

<400>  23

Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu His Phe Ala His 
1               5                   10                  15      


Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile Glu Trp Thr Leu 
            20                  25                  30          


Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala Glu Leu Ser Val 
        35                  40                  45              


Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg Phe Glu Phe Leu 
    50                  55                  60                  


Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe Thr Phe Ser His 
65                  70                  75                  80  


Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr Val His His Leu 
                85                  90                  95      


Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln Ser Lys Asn Phe 
            100                 105                 110         


Leu Val Pro 
        115 


<210>  24
<211>  3429
<212>  DNA
<213>  Homo sapiens


<220>
<223>  Interleukin 17 receptor A (IL17RA)

<400>  24
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg       60

aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga      120

cgccagccgg gccatggggg ccgcacgcag cccgccgtcc gctgtcccgg ggcccctgct      180

ggggctgctc ctgctgctcc tgggcgtgct ggccccgggt ggcgcctccc tgcgactcct      240

ggaccaccgg gcgctggtct gctcccagcc ggggctaaac tgcacggtca agaatagtac      300

ctgcctggat gacagctgga ttcaccctcg aaacctgacc ccctcctccc caaaggacct      360

gcagatccag ctgcactttg cccacaccca acaaggagac ctgttccccg tggctcacat      420

cgaatggaca ctgcagacag acgccagcat cctgtacctc gagggtgcag agttatctgt      480

cctgcagctg aacaccaatg aacgtttgtg cgtcaggttt gagtttctgt ccaaactgag      540

gcatcaccac aggcggtggc gttttacctt cagccacttt gtggttgacc ctgaccagga      600

atatgaggtg accgttcacc acctgcccaa gcccatccct gatggggacc caaaccacca      660

gtccaagaat ttccttgtgc ctgactgtga gcacgccagg atgaaggtaa ccacgccatg      720

catgagctca ggcagcctgt gggaccccaa catcaccgtg gagaccctgg aggcccacca      780

gctgcgtgtg agcttcaccc tgtggaacga atctacccat taccagatcc tgctgaccag      840

ttttccgcac atggagaacc acagttgctt tgagcacatg caccacatac ctgcgcccag      900

accagaagag ttccaccagc gatccaacgt cacactcact ctacgcaacc ttaaagggtg      960

ctgtcgccac caagtgcaga tccagccctt cttcagcagc tgcctcaatg actgcctcag     1020

acactccgcg actgtttcct gcccagaaat gccagacact ccagaaccaa ttccggacta     1080

catgcccctg tgggtgtact ggttcatcac gggcatctcc atcctgctgg tgggctccgt     1140

catcctgctc atcgtctgca tgacctggag gctagctggg cctggaagtg aaaaatacag     1200

tgatgacacc aaatacaccg atggcctgcc tgcggctgac ctgatccccc caccgctgaa     1260

gcccaggaag gtctggatca tctactcagc cgaccacccc ctctacgtgg acgtggtcct     1320

gaaattcgcc cagttcctgc tcaccgcctg cggcacggaa gtggccctgg acctgctgga     1380

agagcaggcc atctcggagg caggagtcat gacctgggtg ggccgtcaga agcaggagat     1440

ggtggagagc aactctaaga tcatcgtcct gtgctcccgc ggcacgcgcg ccaagtggca     1500

ggcgctcctg ggccgggggg cgcctgtgcg gctgcgctgc gaccacggaa agcccgtggg     1560

ggacctgttc actgcagcca tgaacatgat cctcccggac ttcaagaggc cagcctgctt     1620

cggcacctac gtagtctgct acttcagcga ggtcagctgt gacggcgacg tccccgacct     1680

gttcggcgcg gcgccgcggt acccgctcat ggacaggttc gaggaggtgt acttccgcat     1740

ccaggacctg gagatgttcc agccgggccg catgcaccgc gtaggggagc tgtcggggga     1800

caactacctg cggagcccgg gcggcaggca gctccgcgcc gccctggaca ggttccggga     1860

ctggcaggtc cgctgtcccg actggttcga atgtgagaac ctctactcag cagatgacca     1920

ggatgccccg tccctggacg aagaggtgtt tgaggagcca ctgctgcctc cgggaaccgg     1980

catcgtgaag cgggcgcccc tggtgcgcga gcctggctcc caggcctgcc tggccataga     2040

cccgctggtc ggggaggaag gaggagcagc agtggcaaag ctggaacctc acctgcagcc     2100

ccggggtcag ccagcgccgc agcccctcca caccctggtg ctcgccgcag aggagggggc     2160

cctggtggcc gcggtggagc ctgggcccct ggctgacggt gccgcagtcc ggctggcact     2220

ggcgggggag ggcgaggcct gcccgctgct gggcagcccg ggcgctgggc gaaatagcgt     2280

cctcttcctc cccgtggacc ccgaggactc gccccttggc agcagcaccc ccatggcgtc     2340

tcctgacctc cttccagagg acgtgaggga gcacctcgaa ggcttgatgc tctcgctctt     2400

cgagcagagt ctgagctgcc aggcccaggg gggctgcagt agacccgcca tggtcctcac     2460

agacccacac acgccctacg aggaggagca gcggcagtca gtgcagtctg accagggcta     2520

catctccagg agctccccgc agccccccga gggactcacg gaaatggagg aagaggagga     2580

agaggagcag gacccaggga agccggccct gccactctct cccgaggacc tggagagcct     2640

gaggagcctc cagcggcagc tgcttttccg ccagctgcag aagaactcgg gctgggacac     2700

gatggggtca gagtcagagg ggcccagtgc atgagggcgg ctccccaggg accgcccaga     2760

tcccagcttt gagagaggag tgtgtgtgca cgtattcatc tgtgtgtaca tgtctgcatg     2820

tgtatatgtt cgtgtgtgaa atgtaggctt taaaatgtaa atgtctggat tttaatccca     2880

ggcatccctc ctaacttttc tttgtgcagc ggtctggtta tcgtctatcc ccaggggaat     2940

ccacacagcc cgctcccagg agctaatggt agagcgtcct tgaggctcca ttattcgttc     3000

attcagcatt tattgtgcac ctactatgtg gcgggcattt gggataccaa gataaattgc     3060

atgcggcatg gccccagcca tgaaggaact taaccgctag tgccgaggac acgttaaacg     3120

aacaggatgg gccgggcacg gtggctcacg cctgtaatcc cagcacactg ggaggccgag     3180

gcaggtggat cactctgagg tcaggagttt gagccagcct ggccaacatg gtgaaacccc     3240

atctccacta aaaatagaaa aattagccgg gcatggtgac acatgcctgt agtcctagct     3300

acttgggagg ctgaggcagg agaattgctt gaatctggga ggcagaggtt gcagtgagcc     3360

gagattgtgc cattgcactg cagcctggat gacagagcga gactctatct caaaaaaaaa     3420

aaaaaaaaa                                                             3429


<210>  25
<211>  312
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Full length -- human

<400>  25

Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
                245                 250                 255     


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
            260                 265                 270         


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
        275                 280                 285             


Glu Pro Arg Ser Gly Ser Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
    290                 295                 300                 


Ser Ser His His His His His His 
305                 310         


<210>  26
<211>  280
<212>  PRT
<213>  Homo sapiens


<220>
<223>  New end -- human

<400>  26

Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
                245                 250                 255     


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
            260                 265                 270         


Glu Met Pro Asp Thr Pro Glu Pro 
        275                 280 


<210>  27
<211>  250
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Old end -- human

<400>  27

Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Gly Cys Cys Arg His Gln Val Gln 
                245                 250 


<210>  28
<211>  296
<212>  PRT
<213>  Mus musculus


<220>

<223>  Full length -- mouse

<400>  28

Ser Pro Arg Leu Leu Asp Phe Pro Ala Pro Val Cys Ala Gln Glu Gly 
1               5                   10                  15      


Leu Ser Cys Arg Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile 
            20                  25                  30          


His Pro Lys Asn Leu Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn 
        35                  40                  45              


Leu Ser Val Ser Ser Thr Gln His Gly Glu Leu Val Pro Val Leu His 
    50                  55                  60                  


Val Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly 
65                  70                  75                  80  


Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val 
                85                  90                  95      


Lys Phe Gln Phe Leu Ser Met Leu Gln His His Arg Lys Arg Trp Arg 
            100                 105                 110         


Phe Ser Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val 
        115                 120                 125             


Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His 
    130                 135                 140                 


Lys Ser Lys Ile Ile Phe Val Pro Asp Cys Glu Asp Ser Lys Met Lys 
145                 150                 155                 160 


Met Thr Thr Ser Cys Val Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile 
                165                 170                 175     


Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp Phe Thr Leu 
            180                 185                 190         


Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser Phe Ser Asp 
        195                 200                 205             


Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile Phe Ala Pro 
    210                 215                 220                 


Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe Thr Leu Ser 
225                 230                 235                 240 


Lys Phe His Trp Cys Cys His His His Val Gln Val Gln Pro Phe Phe 
                245                 250                 255     


Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ala Val Thr Val Pro Cys 
            260                 265                 270         


Pro Val Ile Ser Asn Thr Thr Val Pro Lys Pro Val Ala Asp Tyr Ile 
        275                 280                 285             


Pro Leu Trp Glu Pro Arg Ser His 
    290                 295     


<210>  29
<211>  286
<212>  PRT
<213>  Mus musculus


<220>
<223>  New End -- mouse

<400>  29

Ser Pro Arg Leu Leu Asp Phe Pro Ala Pro Val Cys Ala Gln Glu Gly 
1               5                   10                  15      


Leu Ser Cys Arg Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile 
            20                  25                  30          


His Pro Lys Asn Leu Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn 
        35                  40                  45              


Leu Ser Val Ser Ser Thr Gln His Gly Glu Leu Val Pro Val Leu His 
    50                  55                  60                  


Val Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly 
65                  70                  75                  80  


Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val 
                85                  90                  95      


Lys Phe Gln Phe Leu Ser Met Leu Gln His His Arg Lys Arg Trp Arg 
            100                 105                 110         


Phe Ser Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val 
        115                 120                 125             


Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His 
    130                 135                 140                 


Lys Ser Lys Ile Ile Phe Val Pro Asp Cys Glu Asp Ser Lys Met Lys 
145                 150                 155                 160 


Met Thr Thr Ser Cys Val Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile 
                165                 170                 175     


Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp Phe Thr Leu 
            180                 185                 190         


Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser Phe Ser Asp 
        195                 200                 205             


Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile Phe Ala Pro 
    210                 215                 220                 


Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe Thr Leu Ser 
225                 230                 235                 240 


Lys Phe His Trp Cys Cys His His His Val Gln Val Gln Pro Phe Phe 
                245                 250                 255     


Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ala Val Thr Val Pro Cys 
            260                 265                 270         


Pro Val Ile Ser Asn Thr Thr Val Pro Lys Pro Val Ala Asp 
        275                 280                 285     


<210>  30
<211>  252
<212>  PRT
<213>  Mus musculus


<220>
<223>  Old End -- mouse

<400>  30

Ser Pro Arg Leu Leu Asp Phe Pro Ala Pro Val Cys Ala Gln Glu Gly 
1               5                   10                  15      


Leu Ser Cys Arg Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile 
            20                  25                  30          


His Pro Lys Asn Leu Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn 
        35                  40                  45              


Leu Ser Val Ser Ser Thr Gln His Gly Glu Leu Val Pro Val Leu His 
    50                  55                  60                  


Val Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly 
65                  70                  75                  80  


Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val 
                85                  90                  95      


Lys Phe Gln Phe Leu Ser Met Leu Gln His His Arg Lys Arg Trp Arg 
            100                 105                 110         


Phe Ser Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val 
        115                 120                 125             


Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His 
    130                 135                 140                 


Lys Ser Lys Ile Ile Phe Val Pro Asp Cys Glu Asp Ser Lys Met Lys 
145                 150                 155                 160 


Met Thr Thr Ser Cys Val Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile 
                165                 170                 175     


Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp Phe Thr Leu 
            180                 185                 190         


Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser Phe Ser Asp 
        195                 200                 205             


Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile Phe Ala Pro 
    210                 215                 220                 


Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe Thr Leu Ser 
225                 230                 235                 240 


Lys Phe His Trp Cys Cys His His His Val Gln Val 
                245                 250         


<210>  31
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIL-17RA-FN2/linker-PLAD

<400>  31

Asp Cys Glu His Ala Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His 
            20                  25                  30          


Gln Leu Arg Val Ser Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln 
        35                  40                  45              


Ile Leu Leu Thr Ser Phe Pro His Met Glu Asn His Ser Cys Phe Glu 
    50                  55                  60                  


His Met His His Ile Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ser Asn Val Thr Leu Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His 
                85                  90                  95      


Gln Val Gln 
            


<210>  32
<211>  78
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hIL-17RA-FN2 PLAD

<400>  32

Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser 
            20                  25                  30          


Phe Pro His Met Glu Asn His Ser Cys Phe Glu His Met His His Ile 
        35                  40                  45              


Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu 
    50                  55                  60                  


Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln 
65                  70                  75              


<210>  33
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17RA-FN2/linker PLAD

<400>  33

Asp Cys Glu Asp Ser Lys Met Lys Met Thr Thr Ser Cys Val Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Asp Thr Gln 
            20                  25                  30          


His Leu Arg Val Asp Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr Gln 
        35                  40                  45              


Val Leu Leu Glu Ser Phe Ser Asp Ser Glu Asn His Ser Cys Phe Asp 
    50                  55                  60                  


Val Val Lys Gln Ile Phe Ala Pro Arg Gln Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ala Asn Val Thr Phe Thr Leu Ser Lys Phe His Trp Cys Cys His His 
                85                  90                  95      


His Val Gln Val 
            100 


<210>  34
<211>  79
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mIL-17RA-FN2 PLAD

<400>  34

Pro Asn Ile Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser 
            20                  25                  30          


Phe Ser Asp Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile 
        35                  40                  45              


Phe Ala Pro Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe 
    50                  55                  60                  


Thr Leu Ser Lys Phe His Trp Cys Cys His His His Val Gln Val 
65                  70                  75                  


<210>  35
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GEAR construct 3808 - pTT5:IgkL-huIL17RA-LinkerPlad-GSS-F-H 
       Residues 152-250 (of mature IL-17R sequence) - 5 Cys res

<400>  35

Asp Cys Glu His Ala Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser 
1               5                   10                  15      


Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His 
            20                  25                  30          


Gln Leu Arg Val Ser Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln 
        35                  40                  45              


Ile Leu Leu Thr Ser Phe Pro His Met Glu Asn His Ser Cys Phe Glu 
    50                  55                  60                  


His Met His His Ile Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg 
65                  70                  75                  80  


Ser Asn Val Thr Leu Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His 
                85                  90                  95      


Gln Val Gln 
            


<210>  36
<211>  78
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GEAR construct 3808 - pTT5:IgkL-huIL17RA-Plad-GSS-F-H Residues 
       173-250 (of mature IL-17R sequence) - 3 Cys res.

<400>  36

Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser 
1               5                   10                  15      


Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser 
            20                  25                  30          


Phe Pro His Met Glu Asn His Ser Cys Phe Glu His Met His His Ile 
        35                  40                  45              


Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu 
    50                  55                  60                  


Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln 
65                  70                  75              


